locus-tag	class	description
GII78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GII78_RS00010	COG0592	DNA-directed DNA polymerase activity
GII78_RS00015	COG2501	S4 domain
GII78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GII78_RS00030	COG0187	DNA topoisomerase II activity
GII78_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII78_RS00070	COG0516	GMP reductase activity
GII78_RS00070	COG0517	IMP dehydrogenase activity
GII78_RS00075	COG1686	Belongs to the peptidase S11 family
GII78_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GII78_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GII78_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GII78_RS00100	COG1428	Deoxynucleoside kinase
GII78_RS00105	COG1428	Deoxynucleoside kinase
GII78_RS00110	COG3858	chitin binding
GII78_RS00110	COG1388	LysM domain
GII78_RS00115	COG1335	isochorismatase
GII78_RS00120	COG0590	tRNA wobble adenosine to inosine editing
GII78_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GII78_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GII78_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GII78_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GII78_RS00190	COG3853	Toxic anion resistance protein (TelA)
GII78_RS00195	COG1982	Orn Lys Arg decarboxylase major
GII78_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GII78_RS00205	COG3870	Protein conserved in bacteria
GII78_RS00210	COG1728	Protein conserved in bacteria
GII78_RS00215	COG0470	DNA polymerase III
GII78_RS00220	COG1774	PSP1 C-terminal conserved region
GII78_RS00225	COG4467	Involved in initiation control of chromosome replication
GII78_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GII78_RS00235	COG2827	Endonuclease containing a URI domain
GII78_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GII78_RS00245	COG2002	toxin-antitoxin pair type II binding
GII78_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII78_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII78_RS00255	COG0084	hydrolase, TatD family'
GII78_RS00260	COG3584	3D domain protein
GII78_RS00260	COG3583	domain protein
GII78_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII78_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GII78_RS00280	COG4466	Protein conserved in bacteria
GII78_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GII78_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII78_RS00300	COG0251	oxidation-reduction process
GII78_RS00305	COG2088	sporulation resulting in formation of a cellular spore
GII78_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GII78_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GII78_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GII78_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
GII78_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GII78_RS00340	COG2002	toxin-antitoxin pair type II binding
GII78_RS00345	COG2244	polysaccharide biosynthetic process
GII78_RS00350	COG3956	TIGRFAM MazG family protein
GII78_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GII78_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GII78_RS00375	COG1098	S1 RNA binding domain
GII78_RS00390	COG2208	phosphoserine phosphatase activity
GII78_RS00395	COG2304	oxidoreductase activity
GII78_RS00400	COG0515	serine threonine protein kinase
GII78_RS00405	COG0037	tRNA processing
GII78_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GII78_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII78_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GII78_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GII78_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII78_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII78_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII78_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
GII78_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII78_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GII78_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GII78_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GII78_RS00470	COG1396	sequence-specific DNA binding
GII78_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GII78_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GII78_RS00560	COG4463	regulation of RNA biosynthetic process
GII78_RS00565	COG3880	PFAM UvrB UvrC protein
GII78_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GII78_RS00575	COG0542	response to heat
GII78_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GII78_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GII78_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
GII78_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GII78_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GII78_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GII78_RS00610	COG1045	serine acetyltransferase
GII78_RS00615	COG0215	cysteine-tRNA ligase activity
GII78_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GII78_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII78_RS00630	COG3688	RNA-binding protein containing a PIN domain
GII78_RS00635	COG1595	DNA-templated transcription, initiation
GII78_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GII78_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
GII78_RS00660	COG0081	regulation of translation
GII78_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GII78_RS00675	COG2813	Specifically methylates the guanine in position
GII78_RS00680	COG0085	RNA polymerase activity
GII78_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GII78_RS00690	COG1358	cellular component organization or biogenesis
GII78_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GII78_RS00700	COG0049	tRNA binding
GII78_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GII78_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GII78_RS00715	COG0596	Alpha beta hydrolase
GII78_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GII78_RS00730	COG0088	Forms part of the polypeptide exit tunnel
GII78_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GII78_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GII78_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GII78_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GII78_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GII78_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GII78_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GII78_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GII78_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GII78_RS00820	COG0200	Binds to the 23S rRNA
GII78_RS00825	COG0201	protein transport
GII78_RS00830	COG0563	adenylate kinase activity
GII78_RS00835	COG0024	Methionine aminopeptidase
GII78_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GII78_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GII78_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GII78_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GII78_RS00865	COG0202	RNA polymerase activity
GII78_RS00870	COG0203	ribosomal protein L17
GII78_RS00875	COG1122	ATPase activity
GII78_RS00880	COG1122	ATPase activity
GII78_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII78_RS00890	COG0101	tRNA pseudouridine synthase activity
GII78_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GII78_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GII78_RS00905	COG2226	methyltransferase
GII78_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS00920	COG0489	protein tyrosine kinase activity
GII78_RS00930	COG2194	sulfuric ester hydrolase activity
GII78_RS00935	COG0726	polysaccharide deacetylase
GII78_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
GII78_RS01020	COG0385	Bile acid
GII78_RS01025	COG2819	hydrolase of the alpha beta superfamily
GII78_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS01045	COG2207	Transcriptional regulator
GII78_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS01050	COG3876	Protein conserved in bacteria
GII78_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
GII78_RS01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII78_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS01065	COG1263	PTS System
GII78_RS01070	COG1737	Transcriptional regulator
GII78_RS01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GII78_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS01085	COG1683	Conserved Protein
GII78_RS01115	COG1595	DNA-templated transcription, initiation
GII78_RS01120	COG5662	AntiSigma factor
GII78_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GII78_RS01130	COG4856	YbbR-like protein
GII78_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII78_RS01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GII78_RS01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GII78_RS01155	COG2169	Transcriptional regulator
GII78_RS01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII78_RS01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII78_RS01170	COG3002	Belongs to the UPF0753 family
GII78_RS01175	COG0288	reversible hydration of carbon dioxide
GII78_RS01185	COG5609	conserved protein (DUF2294)
GII78_RS01190	COG0640	Transcriptional regulator
GII78_RS01195	COG2814	Major facilitator Superfamily
GII78_RS01210	COG1404	Belongs to the peptidase S8 family
GII78_RS01230	COG1132	(ABC) transporter
GII78_RS01235	COG0596	Alpha beta hydrolase
GII78_RS01240	COG0745	RESPONSE REGULATOR receiver
GII78_RS01245	COG0642	Histidine kinase
GII78_RS01255	COG0515	serine threonine protein kinase
GII78_RS01270	COG1113	amino acid transport
GII78_RS01285	COG2602	Beta-lactamase
GII78_RS01290	COG2124	cytochrome p450
GII78_RS01300	COG0531	amino acid
GII78_RS01305	COG0584	glycerophosphoryl diester phosphodiesterase
GII78_RS01310	COG2271	Major facilitator Superfamily
GII78_RS01320	COG0456	acetyltransferase
GII78_RS01320	COG1846	Transcriptional regulator
GII78_RS01325	COG2271	Major facilitator Superfamily
GII78_RS01335	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS01340	COG0697	spore germination
GII78_RS01345	COG2207	Transcriptional regulator
GII78_RS01345	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS01350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GII78_RS01355	COG3591	Belongs to the peptidase S1B family
GII78_RS01365	COG0596	Alpha beta hydrolase
GII78_RS01370	COG1183	phosphatidylcholine synthase activity
GII78_RS01375	COG0586	Pfam SNARE associated Golgi protein
GII78_RS01380	COG0688	phosphatidylethanolamine metabolic process
GII78_RS01390	COG2312	Erythromycin esterase
GII78_RS01395	COG1054	Belongs to the UPF0176 family
GII78_RS01400	COG1301	dicarboxylic acid transport
GII78_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS01405	COG1263	PTS System
GII78_RS01405	COG2190	(PTS) system
GII78_RS01410	COG0363	glucosamine-6-phosphate deaminase activity
GII78_RS01415	COG2188	Transcriptional regulator
GII78_RS01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII78_RS01430	COG0833	amino acid
GII78_RS01435	COG2040	homocysteine
GII78_RS01445	COG1115	amino acid carrier protein
GII78_RS01450	COG2066	Belongs to the glutaminase family
GII78_RS01455	COG4191	Histidine kinase
GII78_RS01460	COG0784	Response regulator, receiver
GII78_RS01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII78_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS01475	COG2271	Major facilitator Superfamily
GII78_RS01480	COG4948	Mandelate Racemase Muconate Lactonizing
GII78_RS01485	COG2186	Transcriptional regulator
GII78_RS01490	COG2721	sulfolactate sulfo-lyase activity
GII78_RS01495	COG3173	Aminoglycoside phosphotransferase
GII78_RS01510	COG0745	RESPONSE REGULATOR receiver
GII78_RS01515	COG2205	protein histidine kinase activity
GII78_RS01520	COG1131	(ABC) transporter
GII78_RS01540	COG3773	Cell wall hydrolase
GII78_RS01545	COG2304	oxidoreductase activity
GII78_RS01555	COG3540	Alkaline phosphatase
GII78_RS01560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII78_RS01565	COG0805	protein transport
GII78_RS01570	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GII78_RS01575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII78_RS01580	COG0477	Major facilitator Superfamily
GII78_RS01585	COG1309	transcriptional regulator
GII78_RS01590	COG0252	asparaginase activity
GII78_RS01595	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GII78_RS01600	COG1714	RDD family
GII78_RS01605	COG3012	SEC-C Motif Domain Protein
GII78_RS01605	COG1405	negative regulation of cell septum assembly
GII78_RS01610	COG3290	protein histidine kinase activity
GII78_RS01615	COG3279	Response regulator of the LytR AlgR family
GII78_RS01620	COG4555	ABC transporter
GII78_RS01625	COG1668	transmembrane transport
GII78_RS01630	COG0667	Aldo Keto reductase
GII78_RS01645	COG1595	DNA-templated transcription, initiation
GII78_RS01650	COG1595	DNA-templated transcription, initiation
GII78_RS01655	COG1876	peptidase activity
GII78_RS01660	COG0457	Tetratricopeptide repeat
GII78_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS01670	COG0366	Alpha amylase catalytic
GII78_RS01675	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII78_RS01680	COG1121	(ABC) transporter
GII78_RS01685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII78_RS01690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS01695	COG2310	stress, protein
GII78_RS01700	COG2310	stress, protein
GII78_RS01705	COG2310	stress, protein
GII78_RS01710	COG0861	Integral membrane protein TerC family
GII78_RS01720	COG3853	Toxic anion resistance protein (TelA)
GII78_RS01725	COG0477	Major facilitator Superfamily
GII78_RS01730	COG2814	Major facilitator Superfamily
GII78_RS01735	COG0640	Transcriptional regulator
GII78_RS01740	COG0517	IMP dehydrogenase activity
GII78_RS01740	COG4175	Glycine betaine
GII78_RS01745	COG4176	ABC-type proline glycine betaine transport system permease component
GII78_RS01750	COG2113	Glycine betaine
GII78_RS01755	COG1473	amidohydrolase
GII78_RS01760	COG1288	antiporter activity
GII78_RS01770	COG0366	Alpha amylase catalytic
GII78_RS01775	COG0039	L-malate dehydrogenase activity
GII78_RS01780	COG1620	l-lactate permease
GII78_RS01785	COG2814	Major facilitator Superfamily
GII78_RS01790	COG1846	Transcriptional regulator
GII78_RS01795	COG1280	lysine exporter protein (LysE YggA)
GII78_RS01800	COG3403	YqcI/YcgG family
GII78_RS01805	COG1113	amino acid transport
GII78_RS01810	COG3665	Urea carboxylase-associated protein
GII78_RS01815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GII78_RS01820	COG1660	Displays ATPase and GTPase activities
GII78_RS01825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GII78_RS01830	COG2226	methyltransferase
GII78_RS01835	COG0583	DNA-binding transcription factor activity
GII78_RS01840	COG3458	cephalosporin-C deacetylase activity
GII78_RS01845	COG3541	Predicted nucleotidyltransferase
GII78_RS01850	COG0506	proline dehydrogenase activity
GII78_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS01860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII78_RS01865	COG2508	Transcriptional regulator
GII78_RS01870	COG3689	TIGRFAM TIGR03943 family protein
GII78_RS01875	COG0701	Predicted permease
GII78_RS01880	COG2267	carboxylic ester hydrolase activity
GII78_RS01885	COG0492	ferredoxin-NADP+ reductase activity
GII78_RS01890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII78_RS01890	COG1587	Uroporphyrinogen-III synthase
GII78_RS01895	COG2146	nitrite reductase [NAD(P)H] activity
GII78_RS01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII78_RS01905	COG0243	molybdopterin cofactor binding
GII78_RS01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII78_RS01915	COG2223	nitrite transmembrane transporter activity
GII78_RS01920	COG1469	GTP cyclohydrolase I activity
GII78_RS01925	COG1376	ErfK ybiS ycfS ynhG family protein
GII78_RS01935	COG0523	cobalamin synthesis protein
GII78_RS01940	COG0765	amino acid transport
GII78_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS01955	COG1714	RDD family
GII78_RS01965	COG2723	6-phospho-beta-galactosidase activity
GII78_RS01975	COG3209	COG3209 Rhs family protein
GII78_RS01980	COG0840	transmembrane signaling receptor activity
GII78_RS01980	COG3290	protein histidine kinase activity
GII78_RS01985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GII78_RS01990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GII78_RS01995	COG1733	regulation of RNA biosynthetic process
GII78_RS02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS02015	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GII78_RS02020	COG2814	Major facilitator Superfamily
GII78_RS02030	COG0697	spore germination
GII78_RS02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS02045	COG2364	Membrane
GII78_RS02050	COG1126	abc transporter atp-binding protein
GII78_RS02055	COG0765	amino acid transport
GII78_RS02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS02065	COG0583	DNA-binding transcription factor activity
GII78_RS02070	COG0163	prenyltransferase activity
GII78_RS02075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GII78_RS02090	COG0596	Alpha beta hydrolase
GII78_RS02095	COG3104	oligopeptide transport
GII78_RS02100	COG5434	Belongs to the glycosyl hydrolase 28 family
GII78_RS02110	COG0697	spore germination
GII78_RS02120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GII78_RS02125	COG1136	(ABC) transporter
GII78_RS02130	COG0577	efflux transmembrane transporter activity
GII78_RS02135	COG0745	RESPONSE REGULATOR receiver
GII78_RS02140	COG5002	protein histidine kinase activity
GII78_RS02140	COG3850	Histidine kinase
GII78_RS02145	COG0457	Tetratricopeptide repeat
GII78_RS02165	COG0527	aspartate kinase activity
GII78_RS02170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS02175	COG4605	iron ion homeostasis
GII78_RS02180	COG4604	ABC transporter, ATP-binding protein
GII78_RS02185	COG4607	ABC-type enterochelin transport system periplasmic component
GII78_RS02195	COG2814	Major facilitator Superfamily
GII78_RS02200	COG1309	transcriptional regulator
GII78_RS02205	COG0778	Nitroreductase
GII78_RS02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII78_RS02215	COG0640	Transcriptional regulator
GII78_RS02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GII78_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS02235	COG4975	Glucose uptake
GII78_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS02245	COG4549	nuclear export factor GLE1
GII78_RS02250	COG1276	copper resistance
GII78_RS02250	COG2372	response to copper ion
GII78_RS02255	COG1349	DNA-binding transcription factor activity
GII78_RS02265	COG2213	PTS system mannitol-specific
GII78_RS02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS02275	COG0246	Mannitol dehydrogenase
GII78_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
GII78_RS02285	COG0681	Belongs to the peptidase S26 family
GII78_RS02290	COG0412	Dienelactone hydrolase
GII78_RS02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII78_RS02305	COG0561	phosphatase activity
GII78_RS02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GII78_RS02315	COG1914	H( )-stimulated, divalent metal cation uptake system
GII78_RS02320	COG4336	lyase activity
GII78_RS02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GII78_RS02330	COG1984	allophanate hydrolase subunit 2
GII78_RS02335	COG1414	Transcriptional regulator
GII78_RS02340	COG2755	lipolytic protein G-D-S-L family
GII78_RS02350	COG2329	Antibiotic biosynthesis monooxygenase
GII78_RS02355	COG0768	penicillin binding
GII78_RS02360	COG4989	oxidoreductase activity
GII78_RS02365	COG3711	transcriptional antiterminator
GII78_RS02370	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS02375	COG2226	methyltransferase
GII78_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS02385	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS02395	COG3871	stress protein (general stress protein 26)
GII78_RS02405	COG2814	Major facilitator Superfamily
GII78_RS02410	COG1522	sequence-specific DNA binding
GII78_RS02415	COG0551	DNA topoisomerase type I activity
GII78_RS02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII78_RS02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GII78_RS02425	COG3706	GGDEF domain
GII78_RS02430	COG5298	Protein conserved in bacteria
GII78_RS02435	COG1215	transferase activity, transferring glycosyl groups
GII78_RS02445	COG0531	amino acid
GII78_RS02450	COG0494	nUDIX hydrolase
GII78_RS02455	COG0028	Belongs to the TPP enzyme family
GII78_RS02470	COG1914	H( )-stimulated, divalent metal cation uptake system
GII78_RS02475	COG2261	transglycosylase associated protein
GII78_RS02480	COG4876	unkown
GII78_RS02485	COG2217	Heavy metal translocating P-type atpase
GII78_RS02490	COG3729	General stress protein
GII78_RS02495	COG0662	Cupin 2, conserved barrel domain protein
GII78_RS02500	COG2329	Antibiotic biosynthesis monooxygenase
GII78_RS02505	COG3546	catalase activity
GII78_RS02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GII78_RS02515	COG3290	protein histidine kinase activity
GII78_RS02520	COG4565	transcriptional regulatory protein
GII78_RS02525	COG1301	dicarboxylic acid transport
GII78_RS02530	COG0628	permease
GII78_RS02535	COG1131	(ABC) transporter
GII78_RS02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII78_RS02550	COG1960	acyl-CoA dehydrogenase activity
GII78_RS02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII78_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
GII78_RS02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GII78_RS02585	COG0513	Belongs to the DEAD box helicase family
GII78_RS02590	COG3402	PFAM membrane-flanked domain
GII78_RS02595	COG3428	Bacterial PH domain
GII78_RS02600	COG0705	Rhomboid family
GII78_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
GII78_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GII78_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII78_RS02620	COG0864	Transcriptional regulator
GII78_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
GII78_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS02640	COG2172	sigma factor antagonist activity
GII78_RS02645	COG2208	phosphoserine phosphatase activity
GII78_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS02655	COG2172	sigma factor antagonist activity
GII78_RS02660	COG1191	sigma factor activity
GII78_RS02665	COG2208	phosphoserine phosphatase activity
GII78_RS02680	COG1673	EVE domain
GII78_RS02685	COG1846	Transcriptional regulator
GII78_RS02690	COG2183	response to ionizing radiation
GII78_RS02700	COG3091	SprT-like family
GII78_RS02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS02785	COG1476	TRANSCRIPTIONal
GII78_RS02805	COG0693	protein deglycase activity
GII78_RS02810	COG1278	Cold shock
GII78_RS02815	COG1329	Transcriptional regulator
GII78_RS02820	COG0697	spore germination
GII78_RS02825	COG2207	Transcriptional regulator
GII78_RS02825	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS02830	COG0697	spore germination
GII78_RS02835	COG2207	Transcriptional regulator
GII78_RS02835	COG3708	Transcriptional regulator
GII78_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS02845	COG0477	Major facilitator Superfamily
GII78_RS02855	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GII78_RS02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS02890	COG1309	transcriptional regulator
GII78_RS02895	COG0697	spore germination
GII78_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS02905	COG2030	dehydratase
GII78_RS02910	COG3545	Serine hydrolase
GII78_RS02915	COG1733	regulation of RNA biosynthetic process
GII78_RS02920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS02925	COG1733	regulation of RNA biosynthetic process
GII78_RS02930	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII78_RS02935	COG2814	Major facilitator Superfamily
GII78_RS02940	COG1309	transcriptional regulator
GII78_RS02950	COG0640	Transcriptional regulator
GII78_RS02955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GII78_RS02965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS02970	COG0697	spore germination
GII78_RS02980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GII78_RS02985	COG0640	Transcriptional regulator
GII78_RS02990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII78_RS03005	COG4585	Histidine kinase
GII78_RS03010	COG2197	response regulator
GII78_RS03015	COG2409	Drug exporters of the RND superfamily
GII78_RS03020	COG0596	Alpha beta hydrolase
GII78_RS03025	COG1811	Na channel or pump
GII78_RS03030	COG0789	Transcriptional regulator
GII78_RS03030	COG4978	Transcriptional regulator
GII78_RS03035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII78_RS03040	COG0778	Nitroreductase
GII78_RS03045	COG0346	lactoylglutathione lyase activity
GII78_RS03050	COG2259	Doxx family
GII78_RS03055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS03070	COG2323	membrane
GII78_RS03075	COG2323	membrane
GII78_RS03080	COG0071	Belongs to the small heat shock protein (HSP20) family
GII78_RS03095	COG1309	transcriptional regulator
GII78_RS03110	COG0488	(ABC) transporter
GII78_RS03115	COG1113	amino acid transport
GII78_RS03120	COG2318	DinB family
GII78_RS03125	COG1846	Transcriptional regulator
GII78_RS03130	COG2409	Drug exporters of the RND superfamily
GII78_RS03130	COG1033	growth of symbiont in host cell
GII78_RS03135	COG0778	Nitroreductase
GII78_RS03140	COG1846	Transcriptional regulator
GII78_RS03145	COG2814	Major facilitator Superfamily
GII78_RS03150	COG0730	response to heat
GII78_RS03155	COG1802	Transcriptional regulator
GII78_RS03160	COG1388	LysM domain
GII78_RS03160	COG3858	chitin binding
GII78_RS03165	COG1819	glycosyl
GII78_RS03175	COG1785	Belongs to the alkaline phosphatase family
GII78_RS03180	COG5646	InterPro IPR014922
GII78_RS03190	COG0454	-acetyltransferase
GII78_RS03195	COG1078	dGTPase activity
GII78_RS03200	COG1388	LysM domain
GII78_RS03205	COG2814	Major facilitator Superfamily
GII78_RS03210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII78_RS03215	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII78_RS03220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII78_RS03225	COG2723	6-phospho-beta-galactosidase activity
GII78_RS03230	COG2188	Transcriptional regulator
GII78_RS03235	COG1940	carbohydrate kinase activity
GII78_RS03240	COG1482	cell wall glycoprotein biosynthetic process
GII78_RS03245	COG4124	Belongs to the glycosyl hydrolase 26 family
GII78_RS03290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GII78_RS03295	COG0802	atpase or kinase
GII78_RS03300	COG1214	PFAM Peptidase M22, glycoprotease
GII78_RS03305	COG0456	acetyltransferase
GII78_RS03310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GII78_RS03315	COG0488	(ABC) transporter
GII78_RS03320	COG0315	cyclic pyranopterin monophosphate synthase activity
GII78_RS03325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GII78_RS03330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII78_RS03335	COG0805	protein transport
GII78_RS03345	COG1266	CAAX protease self-immunity
GII78_RS03355	COG0459	protein refolding
GII78_RS03375	COG5444	nuclease activity
GII78_RS03385	COG2322	membrane
GII78_RS03400	COG0457	Tetratricopeptide repeat
GII78_RS03405	COG1063	alcohol dehydrogenase
GII78_RS03410	COG2211	Major facilitator Superfamily
GII78_RS03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII78_RS03420	COG1842	Phage shock protein A
GII78_RS03425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII78_RS03430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GII78_RS03435	COG4260	virion core protein, lumpy skin disease virus
GII78_RS03445	COG2814	Major facilitator Superfamily
GII78_RS03450	COG1063	alcohol dehydrogenase
GII78_RS03455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GII78_RS03460	COG0823	Involved in the tonB-independent uptake of proteins
GII78_RS03475	COG2267	carboxylic ester hydrolase activity
GII78_RS03485	COG2132	Multicopper oxidase
GII78_RS03490	COG1113	amino acid transport
GII78_RS03500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII78_RS03505	COG0714	Associated with various cellular activities
GII78_RS03510	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GII78_RS03515	COG1305	Transglutaminase-like
GII78_RS03520	COG0519	Catalyzes the synthesis of GMP from XMP
GII78_RS03520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GII78_RS03525	COG2252	PERMEase
GII78_RS03530	COG3064	Membrane
GII78_RS03540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GII78_RS03550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GII78_RS03555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GII78_RS03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GII78_RS03565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GII78_RS03570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII78_RS03575	COG0047	phosphoribosylformylglycinamidine synthase activity
GII78_RS03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII78_RS03585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GII78_RS03590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GII78_RS03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GII78_RS03600	COG0138	bifunctional purine biosynthesis protein purh
GII78_RS03605	COG0151	Belongs to the GarS family
GII78_RS03610	COG1522	sequence-specific DNA binding
GII78_RS03615	COG0531	amino acid
GII78_RS03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII78_RS03630	COG1470	cell adhesion involved in biofilm formation
GII78_RS03635	COG4496	protein, YerC YecD
GII78_RS03640	COG0069	glutamate synthase activity
GII78_RS03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GII78_RS03650	COG0210	DNA helicase
GII78_RS03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GII78_RS03660	COG4851	CamS sex pheromone cAM373 precursor
GII78_RS03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII78_RS03670	COG1285	pathogenesis
GII78_RS03675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII78_RS03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII78_RS03685	COG0154	amidase activity
GII78_RS03690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII78_RS03695	COG1309	transcriptional regulator
GII78_RS03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GII78_RS03705	COG1597	lipid kinase activity
GII78_RS03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII78_RS03755	COG5444	nuclease activity
GII78_RS03760	COG3391	amine dehydrogenase activity
GII78_RS03765	COG0457	Tetratricopeptide repeat
GII78_RS03775	COG0217	transcriptional regulatory protein
GII78_RS03785	COG1309	transcriptional regulator
GII78_RS03790	COG3631	Ketosteroid isomerase-related protein
GII78_RS03795	COG0702	epimerase
GII78_RS03810	COG3546	catalase activity
GII78_RS03815	COG0454	-acetyltransferase
GII78_RS03825	COG5578	integral membrane protein
GII78_RS03830	COG2972	Histidine kinase
GII78_RS03835	COG2207	Transcriptional regulator
GII78_RS03835	COG4753	response regulator
GII78_RS03840	COG1653	transport
GII78_RS03845	COG1175	transmembrane transport
GII78_RS03850	COG0395	ABC-type sugar transport system, permease component
GII78_RS03855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII78_RS03860	COG2207	Transcriptional regulator
GII78_RS03865	COG2755	lipolytic protein G-D-S-L family
GII78_RS03875	COG5578	integral membrane protein
GII78_RS03880	COG3401	FG-GAP repeat protein
GII78_RS03885	COG3401	FG-GAP repeat protein
GII78_RS03890	COG2755	lipolytic protein G-D-S-L family
GII78_RS03895	COG1874	Beta-galactosidase
GII78_RS03905	COG1653	transport
GII78_RS03910	COG4209	transmembrane transport
GII78_RS03915	COG0395	ABC-type sugar transport system, permease component
GII78_RS03920	COG1486	melibiose metabolic process
GII78_RS03925	COG2323	membrane
GII78_RS03930	COG2329	Antibiotic biosynthesis monooxygenase
GII78_RS03935	COG0346	lactoylglutathione lyase activity
GII78_RS03950	COG5583	Uncharacterized small protein (DUF2292)
GII78_RS03955	COG0670	Belongs to the BI1 family
GII78_RS03960	COG0697	spore germination
GII78_RS03965	COG1846	Transcriptional regulator
GII78_RS03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GII78_RS03985	COG2124	cytochrome p450
GII78_RS03985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII78_RS03990	COG1368	sulfuric ester hydrolase activity
GII78_RS03995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GII78_RS04000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII78_RS04005	COG1442	glycosyl transferase family 8
GII78_RS04010	COG1216	Glycosyl transferase, family 2
GII78_RS04015	COG1442	glycosyl transferase family 8
GII78_RS04020	COG2223	nitrite transmembrane transporter activity
GII78_RS04025	COG1011	Hydrolase
GII78_RS04030	COG0531	amino acid
GII78_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS04040	COG0840	transmembrane signaling receptor activity
GII78_RS04045	COG0488	(ABC) transporter
GII78_RS04055	COG0789	Transcriptional regulator
GII78_RS04060	COG2814	Major facilitator Superfamily
GII78_RS04070	COG0488	(ABC) transporter
GII78_RS04075	COG0513	Belongs to the DEAD box helicase family
GII78_RS04080	COG0456	acetyltransferase
GII78_RS04085	COG2130	NADP-dependent
GII78_RS04090	COG2211	Major facilitator Superfamily
GII78_RS04095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GII78_RS04100	COG1120	ATPase activity
GII78_RS04105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS04115	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GII78_RS04130	COG3866	Pectate lyase
GII78_RS04135	COG0471	metal ion transport
GII78_RS04140	COG3290	protein histidine kinase activity
GII78_RS04145	COG4565	transcriptional regulatory protein
GII78_RS04150	COG3181	Tripartite tricarboxylate transporter family receptor
GII78_RS04155	COG2851	Citrate transporter
GII78_RS04160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS04165	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GII78_RS04170	COG1254	Belongs to the acylphosphatase family
GII78_RS04175	COG2258	MOSC domain
GII78_RS04195	COG0024	Methionine aminopeptidase
GII78_RS04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS04200	COG1263	PTS System
GII78_RS04205	COG1368	sulfuric ester hydrolase activity
GII78_RS04220	COG1115	amino acid carrier protein
GII78_RS04225	COG0531	amino acid
GII78_RS04240	COG0697	spore germination
GII78_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS04245	COG1263	PTS System
GII78_RS04250	COG0366	Alpha amylase catalytic
GII78_RS04255	COG2188	Transcriptional regulator
GII78_RS04260	COG0778	Nitroreductase
GII78_RS04265	COG0737	Belongs to the 5'-nucleotidase family
GII78_RS04270	COG0693	protein deglycase activity
GII78_RS04275	COG2814	Major facilitator Superfamily
GII78_RS04280	COG4840	Belongs to the UPF0435 family
GII78_RS04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII78_RS04290	COG4980	gas vesicle protein
GII78_RS04295	COG1295	ribonuclease BN
GII78_RS04300	COG0477	Major facilitator Superfamily
GII78_RS04305	COG0387	Pfam Sodium calcium exchanger
GII78_RS04315	COG0668	transmembrane transport
GII78_RS04320	COG0535	radical SAM domain protein
GII78_RS04330	COG0726	polysaccharide deacetylase
GII78_RS04335	COG2084	Dehydrogenase
GII78_RS04340	COG0598	Magnesium transport protein CorA
GII78_RS04345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GII78_RS04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII78_RS04360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GII78_RS04365	COG4637	Psort location Cytoplasmic, score
GII78_RS04370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII78_RS04375	COG0022	dehydrogenase e1 component
GII78_RS04380	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII78_RS04385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII78_RS04390	COG3284	Transcriptional regulator
GII78_RS04400	COG1742	UPF0060 membrane protein
GII78_RS04420	COG4842	Belongs to the WXG100 family
GII78_RS04425	COG1486	melibiose metabolic process
GII78_RS04430	COG1737	Transcriptional regulator
GII78_RS04435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS04435	COG1263	PTS System
GII78_RS04440	COG5434	Belongs to the glycosyl hydrolase 28 family
GII78_RS04445	COG1132	(ABC) transporter
GII78_RS04450	COG1132	(ABC) transporter
GII78_RS04455	COG2259	Doxx family
GII78_RS04460	COG2514	catechol 2,3-dioxygenase activity
GII78_RS04465	COG4585	Histidine kinase
GII78_RS04470	COG2197	response regulator
GII78_RS04475	COG1131	(ABC) transporter
GII78_RS04480	COG0842	Transport permease protein
GII78_RS04480	COG1511	domain protein
GII78_RS04485	COG0842	Transport permease protein
GII78_RS04490	COG1695	Transcriptional regulator
GII78_RS04495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GII78_RS04500	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GII78_RS04505	COG2318	DinB family
GII78_RS04510	COG2814	Major facilitator Superfamily
GII78_RS04515	COG1846	Transcriptional regulator
GII78_RS04520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GII78_RS04520	COG0392	lysyltransferase activity
GII78_RS04525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS04530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS04535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS04540	COG0384	phenazine biosynthesis protein PhzF
GII78_RS04545	COG0778	Nitroreductase
GII78_RS04560	COG1090	epimerase
GII78_RS04565	COG2137	regulation of response to DNA damage stimulus
GII78_RS04575	COG2814	Major facilitator Superfamily
GII78_RS04590	COG3103	Sh3 type 3 domain protein
GII78_RS04595	COG5658	integral membrane protein
GII78_RS04600	COG0596	Alpha beta hydrolase
GII78_RS04605	COG0463	Glycosyl transferase, family 2
GII78_RS04610	COG4485	Bacterial membrane protein, YfhO
GII78_RS04615	COG1988	membrane-bound metal-dependent
GII78_RS04620	COG1194	a g-specific adenine glycosylase
GII78_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS04645	COG3557	Belongs to the UPF0374 family
GII78_RS04650	COG1132	(ABC) transporter
GII78_RS04655	COG4129	membrane
GII78_RS04660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII78_RS04665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GII78_RS04670	COG0735	belongs to the Fur family
GII78_RS04780	COG4326	sporulation control protein
GII78_RS04790	COG5577	PFAM Coat F domain
GII78_RS04795	COG3340	Belongs to the peptidase S51 family
GII78_RS04800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GII78_RS04805	COG0277	FAD linked oxidase domain protein
GII78_RS04815	COG0753	catalase activity
GII78_RS04820	COG1116	anion transmembrane transporter activity
GII78_RS04825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII78_RS04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII78_RS04835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS04845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GII78_RS04855	COG1476	TRANSCRIPTIONal
GII78_RS04865	COG3382	B3 4 domain protein
GII78_RS04870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GII78_RS04880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GII78_RS04885	COG0789	Transcriptional regulator
GII78_RS04890	COG1664	Polymer-forming cytoskeletal
GII78_RS04895	COG1664	Polymer-forming cytoskeletal
GII78_RS04900	COG2766	serine protein kinase
GII78_RS04905	COG2718	Belongs to the UPF0229 family
GII78_RS04910	COG1846	Transcriptional regulator
GII78_RS04915	COG1566	PFAM secretion protein HlyD family protein
GII78_RS04920	COG2814	Major facilitator Superfamily
GII78_RS04925	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII78_RS04945	COG1725	Transcriptional regulator
GII78_RS04950	COG1131	(ABC) transporter
GII78_RS04955	COG1131	(ABC) transporter
GII78_RS04960	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII78_RS04965	COG1278	Cold shock
GII78_RS04970	COG1464	Belongs to the NlpA lipoprotein family
GII78_RS04975	COG3706	GGDEF domain
GII78_RS04980	COG1823	symporter activity
GII78_RS05000	COG5577	PFAM Coat F domain
GII78_RS05005	COG0737	Belongs to the 5'-nucleotidase family
GII78_RS05005	COG4085	toxin activity
GII78_RS05005	COG1525	nuclease
GII78_RS05010	COG3764	Sortase (surface protein transpeptidase)
GII78_RS05015	COG0564	pseudouridine synthase activity
GII78_RS05025	COG0517	IMP dehydrogenase activity
GII78_RS05030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII78_RS05035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII78_RS05035	COG3153	acetyltransferase
GII78_RS05040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII78_RS05045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GII78_RS05050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GII78_RS05055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GII78_RS05060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GII78_RS05065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII78_RS05070	COG2203	Gaf domain
GII78_RS05070	COG4585	Histidine kinase
GII78_RS05075	COG2197	response regulator
GII78_RS05080	COG0431	NADPH-dependent FMN reductase
GII78_RS05095	COG0791	NLP P60 protein
GII78_RS05095	COG1388	LysM domain
GII78_RS05100	COG1959	2 iron, 2 sulfur cluster binding
GII78_RS05105	COG0668	transmembrane transport
GII78_RS05110	COG2719	SpoVR family
GII78_RS05115	COG1785	Belongs to the alkaline phosphatase family
GII78_RS05120	COG0791	NLP P60 protein
GII78_RS05120	COG1388	LysM domain
GII78_RS05125	COG0583	DNA-binding transcription factor activity
GII78_RS05130	COG0372	Belongs to the citrate synthase family
GII78_RS05135	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS05140	COG0531	amino acid
GII78_RS05145	COG0733	neurotransmitter:sodium symporter activity
GII78_RS05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS05155	COG0456	acetyltransferase
GII78_RS05170	COG1595	DNA-templated transcription, initiation
GII78_RS05175	COG0667	Aldo Keto reductase
GII78_RS05180	COG0204	Acyl-transferase
GII78_RS05185	COG1253	flavin adenine dinucleotide binding
GII78_RS05190	COG0789	Transcriptional regulator
GII78_RS05195	COG0436	Aminotransferase
GII78_RS05200	COG1253	flavin adenine dinucleotide binding
GII78_RS05205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII78_RS05210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII78_RS05215	COG0584	glycerophosphoryl diester phosphodiesterase
GII78_RS05225	COG0668	transmembrane transport
GII78_RS05230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GII78_RS05235	COG0726	polysaccharide deacetylase
GII78_RS05240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII78_RS05245	COG1757	Na H antiporter
GII78_RS05250	COG0589	response to stress
GII78_RS05260	COG1132	(ABC) transporter
GII78_RS05265	COG1132	(ABC) transporter
GII78_RS05270	COG0702	epimerase
GII78_RS05290	COG0189	ligase activity
GII78_RS05295	COG0189	ligase activity
GII78_RS05300	COG4399	Belongs to the UPF0754 family
GII78_RS05305	COG3679	Belongs to the UPF0342 family
GII78_RS05310	COG4335	DNA alkylation repair
GII78_RS05315	COG0561	phosphatase activity
GII78_RS05320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII78_RS05325	COG0475	glutathione-regulated potassium exporter activity
GII78_RS05330	COG0490	domain, Protein
GII78_RS05340	COG1024	Enoyl-CoA hydratase
GII78_RS05350	COG4152	abc transporter atp-binding protein
GII78_RS05355	COG1668	transmembrane transport
GII78_RS05360	COG0420	3'-5' exonuclease activity
GII78_RS05365	COG4717	serine-type aminopeptidase activity
GII78_RS05370	COG3481	metal-dependent phosphohydrolase, HD sub domain
GII78_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII78_RS05410	COG1846	Transcriptional regulator
GII78_RS05415	COG4980	gas vesicle protein
GII78_RS05430	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GII78_RS05435	COG0537	adenosine 5'-monophosphoramidase activity
GII78_RS05440	COG1131	(ABC) transporter
GII78_RS05445	COG4473	ABC transporter
GII78_RS05455	COG1473	amidohydrolase
GII78_RS05460	COG3069	C4-dicarboxylate transmembrane transporter activity
GII78_RS05470	COG2329	Antibiotic biosynthesis monooxygenase
GII78_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII78_RS05480	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GII78_RS05485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GII78_RS05490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GII78_RS05495	COG1309	transcriptional regulator
GII78_RS05500	COG1511	domain protein
GII78_RS05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII78_RS05510	COG4377	Putative membrane peptidase family (DUF2324)
GII78_RS05520	COG1363	Peptidase, m42
GII78_RS05525	COG4405	Protein conserved in bacteria
GII78_RS05530	COG1301	dicarboxylic acid transport
GII78_RS05540	COG1234	tRNA 3'-trailer cleavage
GII78_RS05545	COG0095	Lipoate-protein ligase
GII78_RS05550	COG0702	epimerase
GII78_RS05555	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS05565	COG0501	Belongs to the peptidase M48B family
GII78_RS05575	COG0456	acetyltransferase
GII78_RS05580	COG0604	alcohol dehydrogenase
GII78_RS05585	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GII78_RS05590	COG0406	alpha-ribazole phosphatase activity
GII78_RS05595	COG0183	Belongs to the thiolase family
GII78_RS05600	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS05605	COG1268	BioY protein
GII78_RS05610	COG0840	transmembrane signaling receptor activity
GII78_RS05615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII78_RS05615	COG0723	plastoquinol--plastocyanin reductase activity
GII78_RS05620	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS05630	COG4903	ComK protein
GII78_RS05635	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS05645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII78_RS05660	COG0398	Pfam SNARE associated Golgi protein
GII78_RS05665	COG0681	Belongs to the peptidase S26 family
GII78_RS05670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GII78_RS05675	COG1846	Transcriptional regulator
GII78_RS05680	COG0738	Major facilitator superfamily
GII78_RS05685	COG0673	inositol 2-dehydrogenase activity
GII78_RS05690	COG0561	phosphatase activity
GII78_RS05695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII78_RS05700	COG1609	Transcriptional regulator
GII78_RS05705	COG3180	Ammonia monooxygenase
GII78_RS05710	COG2814	Major facilitator Superfamily
GII78_RS05710	COG0477	Major facilitator Superfamily
GII78_RS05715	COG4533	DNA binding
GII78_RS05725	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GII78_RS05730	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GII78_RS05735	COG1074	ATP-dependent DNA helicase activity
GII78_RS05740	COG0420	3'-5' exonuclease activity
GII78_RS05745	COG0419	ATPase involved in DNA repair
GII78_RS05750	COG1403	HNH endonuclease
GII78_RS05790	COG5337	Spore coat protein CotH
GII78_RS05795	COG0179	Fumarylacetoacetate (FAA) hydrolase
GII78_RS05805	COG1404	Belongs to the peptidase S8 family
GII78_RS05815	COG0367	asparagine synthase
GII78_RS05820	COG2318	DinB family
GII78_RS05825	COG1562	ergosterol biosynthetic process
GII78_RS05830	COG0534	Mate efflux family protein
GII78_RS05835	COG2207	Transcriptional regulator
GII78_RS05835	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS05840	COG1609	Transcriptional regulator
GII78_RS05845	COG0673	inositol 2-dehydrogenase activity
GII78_RS05850	COG2318	DinB family
GII78_RS05855	COG1279	arginine transmembrane transporter activity
GII78_RS05860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII78_RS05865	COG1357	PFAM Pentapeptide repeats (8 copies)
GII78_RS05870	COG2267	carboxylic ester hydrolase activity
GII78_RS05875	COG0529	Catalyzes the synthesis of activated sulfate
GII78_RS05880	COG2046	Belongs to the sulfate adenylyltransferase family
GII78_RS05885	COG0175	sulfate reduction
GII78_RS05890	COG2045	Belongs to the ComB family
GII78_RS05895	COG1809	phosphosulfolactate synthase activity
GII78_RS05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS05905	COG4948	Mandelate Racemase Muconate Lactonizing
GII78_RS05910	COG2814	Major facilitator Superfamily
GII78_RS05915	COG0454	-acetyltransferase
GII78_RS05920	COG2153	protein acetylation
GII78_RS05925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GII78_RS05925	COG0646	methionine synthase
GII78_RS05930	COG1666	GTP binding
GII78_RS05935	COG2996	Protein conserved in bacteria
GII78_RS05955	COG1695	Transcriptional regulator
GII78_RS05970	COG3227	Zinc metalloprotease (Elastase)
GII78_RS05975	COG1307	EDD domain protein, DegV family
GII78_RS05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS05995	COG0561	phosphatase activity
GII78_RS06000	COG1073	alpha beta
GII78_RS06005	COG2151	metal-sulfur cluster biosynthetic enzyme
GII78_RS06015	COG0277	FAD linked oxidase domain protein
GII78_RS06020	COG2271	Major facilitator Superfamily
GII78_RS06025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GII78_RS06030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GII78_RS06040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII78_RS06045	COG0505	Belongs to the CarA family
GII78_RS06050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII78_RS06055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GII78_RS06070	COG2267	carboxylic ester hydrolase activity
GII78_RS06080	COG1744	ABC transporter substrate-binding protein PnrA-like
GII78_RS06095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII78_RS06100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GII78_RS06105	COG5504	Zn-dependent protease
GII78_RS06110	COG0444	Belongs to the ABC transporter superfamily
GII78_RS06115	COG4608	Belongs to the ABC transporter superfamily
GII78_RS06125	COG0601	transmembrane transport
GII78_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII78_RS06140	COG0180	Tryptophanyl-tRNA synthetase
GII78_RS06145	COG4166	transmembrane transport
GII78_RS06150	COG0601	transmembrane transport
GII78_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII78_RS06160	COG0444	Belongs to the ABC transporter superfamily
GII78_RS06165	COG4608	Belongs to the ABC transporter superfamily
GII78_RS06170	COG2814	Major facilitator Superfamily
GII78_RS06175	COG0456	acetyltransferase
GII78_RS06180	COG1393	Belongs to the ArsC family
GII78_RS06185	COG0861	Integral membrane protein TerC family
GII78_RS06195	COG4862	establishment of competence for transformation
GII78_RS06205	COG4469	Competence protein
GII78_RS06210	COG1164	Oligoendopeptidase f
GII78_RS06220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GII78_RS06225	COG2346	COG2346, Truncated hemoglobins
GII78_RS06230	COG0741	lytic transglycosylase activity
GII78_RS06235	COG4116	CYTH
GII78_RS06245	COG2357	RelA SpoT domain protein
GII78_RS06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII78_RS06255	COG0564	pseudouridine synthase activity
GII78_RS06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GII78_RS06265	COG0475	glutathione-regulated potassium exporter activity
GII78_RS06265	COG0569	domain protein
GII78_RS06270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GII78_RS06275	COG0352	thiamine-phosphate diphosphorylase activity
GII78_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII78_RS06285	COG2104	thiamine diphosphate biosynthetic process
GII78_RS06290	COG2022	thiamine diphosphate biosynthetic process
GII78_RS06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII78_RS06300	COG0351	phosphomethylpyrimidine kinase
GII78_RS06305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GII78_RS06360	COG0210	DNA helicase
GII78_RS06370	COG2153	protein acetylation
GII78_RS06375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII78_RS06380	COG2382	esterase
GII78_RS06385	COG0626	cystathionine gamma-synthase activity
GII78_RS06390	COG0626	cystathionine gamma-synthase activity
GII78_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS06400	COG5505	Protein of unknown function (DUF819)
GII78_RS06425	COG5444	nuclease activity
GII78_RS06470	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII78_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS06485	COG3711	transcriptional antiterminator
GII78_RS06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS06490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII78_RS06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS06490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII78_RS06495	COG1482	cell wall glycoprotein biosynthetic process
GII78_RS06505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS06515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GII78_RS06530	COG0109	protoheme IX farnesyltransferase activity
GII78_RS06540	COG0726	polysaccharide deacetylase
GII78_RS06555	COG5504	Zn-dependent protease
GII78_RS06560	COG2205	protein histidine kinase activity
GII78_RS06570	COG3383	formate dehydrogenase (NAD+) activity
GII78_RS06575	COG2427	Protein of unknown function (DUF1641)
GII78_RS06585	COG1051	belongs to the nudix hydrolase family
GII78_RS06595	COG2124	cytochrome p450
GII78_RS06600	COG1819	glycosyl
GII78_RS06610	COG1587	Uroporphyrinogen-III synthase
GII78_RS06615	COG0390	transport system, permease component
GII78_RS06620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII78_RS06625	COG0697	spore germination
GII78_RS06630	COG4297	protein containing double-stranded beta helix domain
GII78_RS06640	COG1252	NADH dehydrogenase
GII78_RS06645	COG1904	glucuronate isomerase
GII78_RS06650	COG2211	Major facilitator Superfamily
GII78_RS06655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GII78_RS06660	COG1063	alcohol dehydrogenase
GII78_RS06665	COG1312	Catalyzes the dehydration of D-mannonate
GII78_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS06675	COG2271	Major facilitator Superfamily
GII78_RS06680	COG1609	Transcriptional regulator
GII78_RS06685	COG0246	Mannitol dehydrogenase
GII78_RS06690	COG2721	sulfolactate sulfo-lyase activity
GII78_RS06695	COG0730	response to heat
GII78_RS06700	COG2318	DinB family
GII78_RS06705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII78_RS06710	COG0457	Tetratricopeptide repeat
GII78_RS06720	COG2350	Protein conserved in bacteria
GII78_RS06725	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII78_RS06725	COG1388	LysM domain
GII78_RS06725	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS06735	COG4195	phage-related replication protein
GII78_RS06740	COG3546	catalase activity
GII78_RS06745	COG2856	Zn peptidase
GII78_RS06750	COG1396	sequence-specific DNA binding
GII78_RS06760	COG1522	sequence-specific DNA binding
GII78_RS06765	COG1484	DNA-dependent DNA replication
GII78_RS06785	COG1595	DNA-templated transcription, initiation
GII78_RS06790	COG3728	DNA packaging
GII78_RS06790	COG5484	DNA packaging
GII78_RS06795	COG1783	phage Terminase large subunit
GII78_RS06800	COG5518	Phage portal protein
GII78_RS06805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII78_RS06810	COG4653	Phage capsid family
GII78_RS06860	COG3953	SLT domain
GII78_RS06860	COG3953	SLT domain
GII78_RS06860	COG5412	phage tail tape measure protein
GII78_RS06860	COG5412	phage tail tape measure protein
GII78_RS06865	COG1652	LysM domain
GII78_RS06870	COG4193	domain, Protein
GII78_RS06880	COG3628	GPW Gp25 family protein
GII78_RS06885	COG3299	homolog of phage Mu protein gp47
GII78_RS06890	COG3778	Protein conserved in bacteria
GII78_RS06930	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS06930	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII78_RS06950	COG0306	phosphate transporter
GII78_RS06955	COG1392	Phosphate transport regulator
GII78_RS06960	COG0531	amino acid
GII78_RS06965	COG0346	lactoylglutathione lyase activity
GII78_RS06970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII78_RS06975	COG0463	Glycosyl transferase, family 2
GII78_RS06980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII78_RS06985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII78_RS06990	COG2362	D-Aminopeptidase
GII78_RS06995	COG0601	transmembrane transport
GII78_RS07000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII78_RS07005	COG0444	Belongs to the ABC transporter superfamily
GII78_RS07010	COG4166	transmembrane transport
GII78_RS07015	COG1619	proteins homologs of microcin C7 resistance protein MccF
GII78_RS07020	COG4948	Mandelate Racemase Muconate Lactonizing
GII78_RS07025	COG0791	NLP P60 protein
GII78_RS07030	COG4608	Belongs to the ABC transporter superfamily
GII78_RS07035	COG2706	6-phosphogluconolactonase activity
GII78_RS07040	COG1834	amidinotransferase
GII78_RS07045	COG1607	acyl-coa hydrolase
GII78_RS07050	COG1017	nitric oxide dioxygenase activity
GII78_RS07050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GII78_RS07060	COG2323	membrane
GII78_RS07065	COG2318	DinB family
GII78_RS07070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS07075	COG2076	Multidrug Resistance protein
GII78_RS07080	COG2076	Multidrug Resistance protein
GII78_RS07085	COG0788	formyltetrahydrofolate deformylase activity
GII78_RS07090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII78_RS07095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GII78_RS07100	COG1764	response to oxidative stress
GII78_RS07105	COG1846	Transcriptional regulator
GII78_RS07110	COG1764	response to oxidative stress
GII78_RS07120	COG0590	tRNA wobble adenosine to inosine editing
GII78_RS07125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII78_RS07130	COG1404	Belongs to the peptidase S8 family
GII78_RS07135	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS07140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII78_RS07145	COG1122	ATPase activity
GII78_RS07150	COG4721	ABC-type cobalt transport system, permease component
GII78_RS07160	COG0745	RESPONSE REGULATOR receiver
GII78_RS07165	COG5002	protein histidine kinase activity
GII78_RS07165	COG3850	Histidine kinase
GII78_RS07170	COG3212	peptidase
GII78_RS07175	COG3212	peptidase
GII78_RS07190	COG2239	Acts as a magnesium transporter
GII78_RS07195	COG0789	Transcriptional regulator
GII78_RS07210	COG1846	Transcriptional regulator
GII78_RS07215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII78_RS07220	COG0726	polysaccharide deacetylase
GII78_RS07225	COG1408	metallophosphoesterase
GII78_RS07235	COG0463	Glycosyl transferase, family 2
GII78_RS07240	COG1793	dna ligase
GII78_RS07240	COG3285	dna ligase
GII78_RS07245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GII78_RS07250	COG3300	MHYT domain
GII78_RS07250	COG5001	Diguanylate cyclase
GII78_RS07255	COG0586	Pfam SNARE associated Golgi protein
GII78_RS07260	COG0861	Integral membrane protein TerC family
GII78_RS07265	COG1191	sigma factor activity
GII78_RS07285	COG0501	Belongs to the peptidase M48B family
GII78_RS07290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII78_RS07305	COG3594	Acyltransferase
GII78_RS07310	COG5002	protein histidine kinase activity
GII78_RS07315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII78_RS07325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GII78_RS07330	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GII78_RS07335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII78_RS07340	COG0436	Aminotransferase
GII78_RS07345	COG1850	ribulose-bisphosphate carboxylase activity
GII78_RS07350	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GII78_RS07355	COG0235	Class ii aldolase
GII78_RS07360	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GII78_RS07365	COG3339	Conserved Protein
GII78_RS07380	COG3852	Histidine kinase
GII78_RS07385	COG1846	Transcriptional regulator
GII78_RS07390	COG1360	Flagellar Motor Protein
GII78_RS07395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII78_RS07400	COG0542	response to heat
GII78_RS07405	COG3949	Membrane
GII78_RS07410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GII78_RS07415	COG0720	synthase
GII78_RS07420	COG0602	queuosine metabolic process
GII78_RS07425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GII78_RS07430	COG1733	regulation of RNA biosynthetic process
GII78_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS07440	COG1388	LysM domain
GII78_RS07440	COG4641	Protein conserved in bacteria
GII78_RS07445	COG1388	LysM domain
GII78_RS07450	COG3858	chitin binding
GII78_RS07460	COG4873	Protein conserved in bacteria
GII78_RS07470	COG3773	Cell wall hydrolase
GII78_RS07475	COG2244	polysaccharide biosynthetic process
GII78_RS07480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS07485	COG2217	Heavy metal translocating P-type atpase
GII78_RS07495	COG0006	proline dipeptidase activity
GII78_RS07500	COG1609	Transcriptional regulator
GII78_RS07505	COG3711	transcriptional antiterminator
GII78_RS07510	COG1263	PTS System
GII78_RS07510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS07510	COG2190	(PTS) system
GII78_RS07515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS07520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GII78_RS07530	COG1533	DNA photolyase activity
GII78_RS07535	COG0456	acetyltransferase
GII78_RS07540	COG0840	transmembrane signaling receptor activity
GII78_RS07545	COG2084	Dehydrogenase
GII78_RS07550	COG2340	Cysteine-rich secretory protein family
GII78_RS07555	COG0768	penicillin binding
GII78_RS07560	COG4191	Histidine kinase
GII78_RS07565	COG0436	Aminotransferase
GII78_RS07575	COG0784	Response regulator, receiver
GII78_RS07575	COG0835	chemotaxis
GII78_RS07585	COG2814	Major facilitator Superfamily
GII78_RS07590	COG1376	ErfK ybiS ycfS ynhG family protein
GII78_RS07595	COG1408	metallophosphoesterase
GII78_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS07605	COG2200	EAL domain
GII78_RS07610	COG4703	Protein of unknown function (DUF1797)
GII78_RS07615	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GII78_RS07625	COG0517	IMP dehydrogenase activity
GII78_RS07630	COG0583	DNA-binding transcription factor activity
GII78_RS07635	COG0716	FMN binding
GII78_RS07645	COG0716	FMN binding
GII78_RS07650	COG2171	N-acyltransferase activity
GII78_RS07655	COG1473	amidohydrolase
GII78_RS07665	COG0668	transmembrane transport
GII78_RS07670	COG0450	alkyl hydroperoxide reductase
GII78_RS07675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS07690	COG0746	molybdenum cofactor guanylyltransferase activity
GII78_RS07695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII78_RS07700	COG0303	'Molybdopterin
GII78_RS07705	COG1763	Mo-molybdopterin cofactor biosynthetic process
GII78_RS07710	COG0314	molybdopterin synthase activity
GII78_RS07715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GII78_RS07720	COG1132	(ABC) transporter
GII78_RS07725	COG1132	(ABC) transporter
GII78_RS07735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GII78_RS07740	COG1136	(ABC) transporter
GII78_RS07745	COG0577	efflux transmembrane transporter activity
GII78_RS07750	COG1349	DNA-binding transcription factor activity
GII78_RS07755	COG1105	Belongs to the carbohydrate kinase PfkB family
GII78_RS07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII78_RS07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII78_RS07760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS07765	COG0681	Belongs to the peptidase S26 family
GII78_RS07775	COG0488	(ABC) transporter
GII78_RS07780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GII78_RS07785	COG2309	aminopeptidase activity
GII78_RS07795	COG1077	Cell shape determining protein MreB Mrl
GII78_RS07800	COG2002	toxin-antitoxin pair type II binding
GII78_RS07805	COG3852	Histidine kinase
GII78_RS07810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GII78_RS07810	COG2105	PFAM AIG2 family protein
GII78_RS07815	COG0569	domain protein
GII78_RS07820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII78_RS07825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII78_RS07830	COG5503	Protein of unknown function (DUF1447)
GII78_RS07835	COG0561	phosphatase activity
GII78_RS07840	COG0242	peptide deformylase activity
GII78_RS07850	COG0497	DNA recombination
GII78_RS07855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII78_RS07860	COG0022	dehydrogenase e1 component
GII78_RS07865	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII78_RS07870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII78_RS07875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS07885	COG1982	Orn Lys Arg decarboxylase major
GII78_RS07890	COG4476	Belongs to the UPF0223 family
GII78_RS07895	COG4493	Belongs to the UPF0637 family
GII78_RS07905	COG0483	inositol monophosphate 1-phosphatase activity
GII78_RS07915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GII78_RS07935	COG1595	DNA-templated transcription, initiation
GII78_RS07955	COG1217	gtp-binding protein TYPA
GII78_RS07965	COG4896	Protein conserved in bacteria
GII78_RS07975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GII78_RS07980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII78_RS07985	COG2066	Belongs to the glutaminase family
GII78_RS07990	COG4838	Belongs to the UPF0358 family
GII78_RS07995	COG0772	Belongs to the SEDS family
GII78_RS08000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GII78_RS08005	COG1612	heme a metabolic process
GII78_RS08010	COG0109	protoheme IX farnesyltransferase activity
GII78_RS08015	COG2010	Cytochrome c
GII78_RS08015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII78_RS08020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII78_RS08025	COG1845	cytochrome c oxidase, subunit III
GII78_RS08030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII78_RS08035	COG3336	cytochrome c oxidase
GII78_RS08045	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GII78_RS08050	COG2340	Cysteine-rich secretory protein family
GII78_RS08065	COG3679	Belongs to the UPF0342 family
GII78_RS08070	COG4471	UPF0298 protein
GII78_RS08075	COG0742	ribosomal rna small subunit methyltransferase
GII78_RS08080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GII78_RS08085	COG3314	Sporulation integral membrane protein YlbJ
GII78_RS08090	COG1752	Esterase of the alpha-beta hydrolase superfamily
GII78_RS08095	COG3480	Lon protease (S16) C-terminal proteolytic domain
GII78_RS08100	COG1323	Belongs to the UPF0348 family
GII78_RS08110	COG1399	metal-binding, possibly nucleic acid-binding protein
GII78_RS08125	COG0454	-acetyltransferase
GII78_RS08130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GII78_RS08135	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GII78_RS08140	COG2001	Belongs to the MraZ family
GII78_RS08145	COG0275	rRNA processing
GII78_RS08150	COG4839	cell division protein FtsL
GII78_RS08155	COG0768	penicillin binding
GII78_RS08160	COG0768	penicillin binding
GII78_RS08165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GII78_RS08170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII78_RS08175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII78_RS08180	COG0772	Belongs to the SEDS family
GII78_RS08185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII78_RS08190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GII78_RS08195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GII78_RS08200	COG3879	Bacterial protein of unknown function (DUF881)
GII78_RS08205	COG3879	Bacterial protein of unknown function (DUF881)
GII78_RS08210	COG3856	small basic protein
GII78_RS08215	COG0849	cell division
GII78_RS08220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GII78_RS08225	COG1404	Belongs to the peptidase S8 family
GII78_RS08225	COG4412	M6 family metalloprotease domain protein
GII78_RS08235	COG1191	sigma factor activity
GII78_RS08240	COG1191	sigma factor activity
GII78_RS08245	COG1119	ATPase activity
GII78_RS08250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII78_RS08255	COG1873	PFAM PRC-barrel domain
GII78_RS08260	COG1496	oxidoreductase activity
GII78_RS08265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GII78_RS08270	COG1799	cell septum assembly
GII78_RS08275	COG0762	integral membrane protein
GII78_RS08280	COG2302	S4 RNA-binding domain
GII78_RS08285	COG3599	regulation of cell shape
GII78_RS08290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GII78_RS08295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII78_RS08300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GII78_RS08305	COG0564	pseudouridine synthase activity
GII78_RS08310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GII78_RS08315	COG2233	PERMEase
GII78_RS08320	COG0540	Belongs to the ATCase OTCase family
GII78_RS08325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII78_RS08330	COG0505	Belongs to the CarA family
GII78_RS08335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII78_RS08340	COG0543	2 iron, 2 sulfur cluster binding
GII78_RS08345	COG0167	dihydroorotate dehydrogenase activity
GII78_RS08350	COG0284	orotidine-5'-phosphate decarboxylase activity
GII78_RS08355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GII78_RS08360	COG0175	sulfate reduction
GII78_RS08365	COG0306	phosphate transporter
GII78_RS08370	COG2046	Belongs to the sulfate adenylyltransferase family
GII78_RS08375	COG0529	Catalyzes the synthesis of activated sulfate
GII78_RS08380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII78_RS08385	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GII78_RS08390	COG1648	precorrin-2 dehydrogenase activity
GII78_RS08395	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GII78_RS08400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GII78_RS08405	COG1561	YicC-like family, N-terminal region
GII78_RS08415	COG0194	GDP metabolic process
GII78_RS08420	COG1758	RNA polymerase activity
GII78_RS08425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII78_RS08430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII78_RS08435	COG0242	peptide deformylase activity
GII78_RS08440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GII78_RS08445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GII78_RS08445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII78_RS08450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GII78_RS08455	COG0631	protein serine/threonine phosphatase activity
GII78_RS08460	COG2815	serine threonine protein kinase
GII78_RS08460	COG0515	serine threonine protein kinase
GII78_RS08465	COG1162	GTPase activity
GII78_RS08470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GII78_RS08475	COG1564	THIamine pyrophosphokinase
GII78_RS08485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GII78_RS08490	COG1302	Protein conserved in bacteria
GII78_RS08495	COG1461	Dihydroxyacetone kinase
GII78_RS08500	COG1760	l-serine dehydratase
GII78_RS08505	COG1760	l-serine dehydratase
GII78_RS08510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GII78_RS08515	COG1349	DNA-binding transcription factor activity
GII78_RS08515	COG2050	protein possibly involved in aromatic compounds catabolism
GII78_RS08520	COG0416	fatty acid biosynthetic process
GII78_RS08525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII78_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS08540	COG0571	ribonuclease III activity
GII78_RS08545	COG1196	nuclear chromosome segregation
GII78_RS08550	COG0552	protein localization to endoplasmic reticulum
GII78_RS08560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GII78_RS08565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GII78_RS08570	COG0228	four-way junction DNA binding
GII78_RS08575	COG1837	Belongs to the UPF0109 family
GII78_RS08585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GII78_RS08590	COG0336	Belongs to the RNA methyltransferase TrmD family
GII78_RS08595	COG0335	large ribosomal subunit rRNA binding
GII78_RS08600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII78_RS08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII78_RS08615	COG2257	FlhB HrpN YscU SpaS Family
GII78_RS08620	COG0045	succinate-CoA ligase (ADP-forming) activity
GII78_RS08625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GII78_RS08630	COG0758	DNA mediated transformation
GII78_RS08635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII78_RS08640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GII78_RS08645	COG4974	Belongs to the 'phage' integrase family
GII78_RS08650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GII78_RS08655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GII78_RS08660	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII78_RS08665	COG1815	bacterial-type flagellum-dependent cell motility
GII78_RS08670	COG1558	bacterial-type flagellum-dependent cell motility
GII78_RS08675	COG1677	Flagellar hook-basal body complex protein FliE
GII78_RS08680	COG1766	The M ring may be actively involved in energy transduction
GII78_RS08685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII78_RS08690	COG1317	bacterial-type flagellum organization
GII78_RS08695	COG1157	protein secretion by the type III secretion system
GII78_RS08700	COG2882	bacterial-type flagellum organization
GII78_RS08705	COG3334	PFAM MgtE intracellular
GII78_RS08710	COG3144	bacterial-type flagellum assembly
GII78_RS08715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GII78_RS08720	COG4786	Flagellar basal body rod
GII78_RS08725	COG1582	Flagellar protein (FlbD)
GII78_RS08730	COG1580	Controls the rotational direction of flagella during chemotaxis
GII78_RS08735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII78_RS08740	COG1776	CheC inhibitor of MCP methylation
GII78_RS08740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII78_RS08745	COG2201	protein-glutamate methylesterase activity
GII78_RS08750	COG3190	flagellar
GII78_RS08755	COG1338	Plays a role in the flagellum-specific transport system
GII78_RS08760	COG1987	bacterial-type flagellum assembly
GII78_RS08765	COG1684	flagellar biosynthetic protein fliR
GII78_RS08770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII78_RS08775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII78_RS08780	COG1419	protein localization to endoplasmic reticulum
GII78_RS08785	COG0455	bacterial-type flagellum organization
GII78_RS08790	COG2201	protein-glutamate methylesterase activity
GII78_RS08795	COG2198	Histidine kinase
GII78_RS08795	COG0643	Histidine kinase
GII78_RS08800	COG0835	chemotaxis
GII78_RS08805	COG1776	CheC inhibitor of MCP methylation
GII78_RS08810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GII78_RS08815	COG1191	sigma factor activity
GII78_RS08825	COG0052	Belongs to the universal ribosomal protein uS2 family
GII78_RS08830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GII78_RS08835	COG0528	UMP kinase activity
GII78_RS08840	COG0233	cytoplasmic translational termination
GII78_RS08845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GII78_RS08850	COG4589	Belongs to the CDS family
GII78_RS08855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GII78_RS08860	COG0750	zinc metalloprotease
GII78_RS08865	COG0442	prolyl-tRNA aminoacylation
GII78_RS08870	COG2176	DNA-directed DNA polymerase activity
GII78_RS08875	COG0779	Required for maturation of 30S ribosomal subunits
GII78_RS08880	COG0195	Participates in both transcription termination and antitermination
GII78_RS08885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GII78_RS08890	COG1358	cellular component organization or biogenesis
GII78_RS08895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GII78_RS08900	COG1550	Protein conserved in bacteria
GII78_RS08905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GII78_RS08910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GII78_RS08915	COG0196	riboflavin kinase activity
GII78_RS08920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GII78_RS08925	COG1185	polyribonucleotide nucleotidyltransferase activity
GII78_RS08930	COG0726	polysaccharide deacetylase
GII78_RS08935	COG0612	Peptidase, M16
GII78_RS08940	COG1873	PFAM PRC-barrel domain
GII78_RS08945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII78_RS08950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII78_RS08955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GII78_RS08960	COG0527	aspartate kinase activity
GII78_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII78_RS08970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII78_RS08975	COG0740	serine-type endopeptidase activity
GII78_RS08985	COG4980	gas vesicle protein
GII78_RS08985	COG1674	ftsk spoiiie
GII78_RS08990	COG2188	Transcriptional regulator
GII78_RS08995	COG2814	Major facilitator Superfamily
GII78_RS09000	COG0612	Peptidase, M16
GII78_RS09005	COG0612	Peptidase, M16
GII78_RS09010	COG0300	oxidoreductase activity
GII78_RS09025	COG1426	Protein conserved in bacteria
GII78_RS09030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GII78_RS09035	COG1546	Belongs to the CinA family
GII78_RS09035	COG1058	Belongs to the CinA family
GII78_RS09040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GII78_RS09045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII78_RS09050	COG1418	mRNA catabolic process
GII78_RS09055	COG1692	metallophosphoesterase
GII78_RS09060	COG2359	stage V sporulation protein S
GII78_RS09065	COG1063	alcohol dehydrogenase
GII78_RS09070	COG0156	8-amino-7-oxononanoate synthase activity
GII78_RS09075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII78_RS09080	COG4550	Control of competence regulator ComK, YlbF/YmcA
GII78_RS09090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GII78_RS09095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GII78_RS09110	COG3226	Transcriptional regulator
GII78_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS09125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII78_RS09130	COG3321	synthase
GII78_RS09135	COG2070	2-Nitropropane dioxygenase
GII78_RS09135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII78_RS09140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII78_RS09145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GII78_RS09150	COG3425	synthase
GII78_RS09155	COG1024	Enoyl-CoA hydratase
GII78_RS09160	COG1024	Enoyl-CoA hydratase
GII78_RS09165	COG0300	oxidoreductase activity
GII78_RS09165	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09165	COG3321	synthase
GII78_RS09170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII78_RS09170	COG3321	synthase
GII78_RS09170	COG0300	oxidoreductase activity
GII78_RS09170	COG4221	oxidoreductase activity
GII78_RS09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII78_RS09175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII78_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS09175	COG3321	synthase
GII78_RS09175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09180	COG4221	oxidoreductase activity
GII78_RS09180	COG3321	synthase
GII78_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09185	COG3321	synthase
GII78_RS09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII78_RS09185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GII78_RS09185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GII78_RS09190	COG2124	cytochrome p450
GII78_RS09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS09205	COG1404	Belongs to the peptidase S8 family
GII78_RS09215	COG4195	phage-related replication protein
GII78_RS09220	COG1764	response to oxidative stress
GII78_RS09225	COG2076	Multidrug Resistance protein
GII78_RS09230	COG2076	Multidrug Resistance protein
GII78_RS09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GII78_RS09250	COG1923	regulation of RNA biosynthetic process
GII78_RS09265	COG1780	Probably involved in ribonucleotide reductase function
GII78_RS09270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII78_RS09275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII78_RS09280	COG4112	unkown
GII78_RS09285	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS09290	COG0464	growth
GII78_RS09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GII78_RS09300	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GII78_RS09305	COG0789	Transcriptional regulator
GII78_RS09310	COG0174	glutamine synthetase
GII78_RS09350	COG1598	PFAM Uncharacterised protein family UPF0150
GII78_RS09430	COG0463	Glycosyl transferase, family 2
GII78_RS09445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS09460	COG3655	Transcriptional regulator
GII78_RS09475	COG0135	phosphoribosylanthranilate isomerase activity
GII78_RS09485	COG2211	Major facilitator Superfamily
GII78_RS09490	COG3507	Belongs to the glycosyl hydrolase 43 family
GII78_RS09495	COG1940	carbohydrate kinase activity
GII78_RS09500	COG2115	Belongs to the xylose isomerase family
GII78_RS09505	COG1070	Carbohydrate kinase
GII78_RS09515	COG1525	nuclease
GII78_RS09520	COG2814	Major facilitator Superfamily
GII78_RS09525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII78_RS09535	COG0756	dUTP diphosphatase activity
GII78_RS09570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII78_RS09585	COG3832	glyoxalase III activity
GII78_RS09595	COG0697	spore germination
GII78_RS09600	COG0531	amino acid
GII78_RS09630	COG4195	phage-related replication protein
GII78_RS09640	COG0346	lactoylglutathione lyase activity
GII78_RS09645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GII78_RS09650	COG1388	LysM domain
GII78_RS09655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII78_RS09660	COG4224	UPF0291 protein
GII78_RS09665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GII78_RS09675	COG3763	UPF0154 protein
GII78_RS09685	COG0785	Cytochrome C biogenesis protein
GII78_RS09690	COG2201	protein-glutamate methylesterase activity
GII78_RS09695	COG4846	Membrane protein involved in cytochrome C biogenesis
GII78_RS09705	COG0071	Belongs to the small heat shock protein (HSP20) family
GII78_RS09720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GII78_RS09725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS09745	COG0824	Thioesterase
GII78_RS09755	COG4841	protein insertion into membrane
GII78_RS09760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GII78_RS09765	COG1832	CoA-binding protein
GII78_RS09770	COG0187	DNA topoisomerase II activity
GII78_RS09775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII78_RS09785	COG1115	amino acid carrier protein
GII78_RS09800	COG5520	Belongs to the glycosyl hydrolase 30 family
GII78_RS09805	COG3507	Belongs to the glycosyl hydrolase 43 family
GII78_RS09810	COG2246	polysaccharide biosynthetic process
GII78_RS09815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII78_RS09820	COG0586	Pfam SNARE associated Golgi protein
GII78_RS09825	COG2404	hydrolase activity, acting on ester bonds
GII78_RS09830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII78_RS09835	COG1024	Enoyl-CoA hydratase
GII78_RS09840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII78_RS09845	COG0511	ligase activity, forming carbon-carbon bonds
GII78_RS09850	COG0439	Biotin carboxylase
GII78_RS09855	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS09860	COG1960	acyl-CoA dehydrogenase activity
GII78_RS09870	COG1649	PFAM Uncharacterised BCR, COG1649
GII78_RS09880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GII78_RS09880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS09905	COG2027	D-alanyl-D-alanine carboxypeptidase
GII78_RS09910	COG2017	converts alpha-aldose to the beta-anomer
GII78_RS09915	COG0534	Mate efflux family protein
GII78_RS09930	COG0582	viral genome integration into host DNA
GII78_RS09935	COG0166	Belongs to the GPI family
GII78_RS09940	COG0405	Gamma-glutamyltransferase
GII78_RS09945	COG0583	DNA-binding transcription factor activity
GII78_RS09950	COG0604	alcohol dehydrogenase
GII78_RS09955	COG0493	'glutamate synthase
GII78_RS09960	COG0067	glutamate synthase
GII78_RS09960	COG0070	glutamate synthase
GII78_RS09960	COG0069	glutamate synthase activity
GII78_RS09965	COG0583	DNA-binding transcription factor activity
GII78_RS09970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII78_RS09975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII78_RS09985	COG0300	oxidoreductase activity
GII78_RS09990	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GII78_RS10000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS10015	COG2814	Major facilitator Superfamily
GII78_RS10020	COG1070	Carbohydrate kinase
GII78_RS10025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GII78_RS10030	COG0243	molybdopterin cofactor binding
GII78_RS10060	COG0840	transmembrane signaling receptor activity
GII78_RS10060	COG5278	phosphoserine phosphatase activity
GII78_RS10065	COG2368	4-hydroxyphenylacetate
GII78_RS10070	COG4305	rare lipoprotein A
GII78_RS10075	COG3619	membrane
GII78_RS10080	COG3866	Pectate lyase
GII78_RS10085	COG2135	peptidase activity
GII78_RS10095	COG2140	Oxalate decarboxylase
GII78_RS10105	COG0456	acetyltransferase
GII78_RS10125	COG2720	vancomycin resistance protein
GII78_RS10135	COG3655	Transcriptional regulator
GII78_RS10140	COG3739	integral membrane protein
GII78_RS10145	COG0583	DNA-binding transcription factor activity
GII78_RS10150	COG0697	spore germination
GII78_RS10160	COG0693	protein deglycase activity
GII78_RS10165	COG2367	Beta-lactamase
GII78_RS10190	COG3848	Pyruvate phosphate dikinase
GII78_RS10190	COG0574	Belongs to the PEP-utilizing enzyme family
GII78_RS10195	COG0726	polysaccharide deacetylase
GII78_RS10200	COG2314	TM2 domain
GII78_RS10205	COG1396	sequence-specific DNA binding
GII78_RS10325	COG0457	Tetratricopeptide repeat
GII78_RS10360	COG4282	regulation of fungal-type cell wall biogenesis
GII78_RS10365	COG1231	oxidoreductase activity
GII78_RS10370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII78_RS10375	COG2207	Transcriptional regulator
GII78_RS10375	COG0662	Cupin 2, conserved barrel domain protein
GII78_RS10380	COG0456	acetyltransferase
GII78_RS10385	COG1309	transcriptional regulator
GII78_RS10390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS10395	COG3708	Transcriptional regulator
GII78_RS10400	COG2378	regulation of single-species biofilm formation
GII78_RS10410	COG0640	Transcriptional regulator
GII78_RS10415	COG0741	lytic transglycosylase activity
GII78_RS10420	COG2322	membrane
GII78_RS10435	COG1619	proteins homologs of microcin C7 resistance protein MccF
GII78_RS10440	COG3239	Fatty acid desaturase
GII78_RS10445	COG4585	Histidine kinase
GII78_RS10450	COG2197	response regulator
GII78_RS10455	COG3584	3D domain protein
GII78_RS10455	COG1388	LysM domain
GII78_RS10460	COG0514	ATP-dependent DNA helicase (RecQ)
GII78_RS10470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII78_RS10475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII78_RS10490	COG0071	Belongs to the small heat shock protein (HSP20) family
GII78_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS10520	COG1657	PFAM Prenyltransferase squalene oxidase
GII78_RS10525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII78_RS10530	COG0733	neurotransmitter:sodium symporter activity
GII78_RS10535	COG0385	Bile acid
GII78_RS10540	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII78_RS10545	COG0567	Dehydrogenase, E1 component
GII78_RS10550	COG4548	von Willebrand factor, type A
GII78_RS10555	COG0714	Associated with various cellular activities
GII78_RS10560	COG2032	superoxide dismutase activity
GII78_RS10565	COG1388	LysM domain
GII78_RS10565	COG0791	NLP P60 protein
GII78_RS10570	COG1819	glycosyl
GII78_RS10575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GII78_RS10580	COG0534	Mate efflux family protein
GII78_RS10585	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS10590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII78_RS10595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII78_RS10605	COG2962	Rard protein
GII78_RS10620	COG2610	gluconate transmembrane transporter activity
GII78_RS10625	COG1942	4-Oxalocrotonate Tautomerase
GII78_RS10630	COG1733	regulation of RNA biosynthetic process
GII78_RS10635	COG0778	Nitroreductase
GII78_RS10640	COG0400	carboxylic ester hydrolase activity
GII78_RS10645	COG0346	lactoylglutathione lyase activity
GII78_RS10655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII78_RS10660	COG0793	Belongs to the peptidase S41A family
GII78_RS10660	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS10665	COG2226	methyltransferase
GII78_RS10675	COG1876	peptidase activity
GII78_RS10680	COG0813	purine-nucleoside phosphorylase activity
GII78_RS10695	COG0671	phosphoesterase, PA-phosphatase related
GII78_RS10715	COG4479	Belongs to the UPF0346 family
GII78_RS10735	COG3331	DNA recombination
GII78_RS10795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII78_RS10825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII78_RS10850	COG0756	dUTP diphosphatase activity
GII78_RS10855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS10875	COG1372	Participates in initiation and elongation during chromosome replication
GII78_RS10875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII78_RS10880	COG1780	Probably involved in ribonucleotide reductase function
GII78_RS10995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GII78_RS11020	COG3584	3D domain protein
GII78_RS11025	COG0587	DNA-directed DNA polymerase activity
GII78_RS11030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII78_RS11035	COG0358	DNA primase activity
GII78_RS11040	COG0305	Participates in initiation and elongation during chromosome replication
GII78_RS11050	COG2887	Belongs to the helicase family. UvrD subfamily
GII78_RS11075	COG3420	alginic acid biosynthetic process
GII78_RS11075	COG5434	Belongs to the glycosyl hydrolase 28 family
GII78_RS11080	COG4195	phage-related replication protein
GII78_RS11100	COG2135	peptidase activity
GII78_RS11105	COG1793	dna ligase
GII78_RS11155	COG1388	LysM domain
GII78_RS11180	COG3645	SOS response
GII78_RS11180	COG3646	Phage regulatory protein
GII78_RS11220	COG3655	Transcriptional regulator
GII78_RS11235	COG0582	viral genome integration into host DNA
GII78_RS11315	COG3655	Transcriptional regulator
GII78_RS11370	COG1395	domain, Protein
GII78_RS11385	COG0776	regulation of translation
GII78_RS11425	COG4373	Mu-like prophage FluMu protein gp28
GII78_RS11525	COG0582	viral genome integration into host DNA
GII78_RS11545	COG1196	nuclear chromosome segregation
GII78_RS11545	COG0739	heme binding
GII78_RS11545	COG0741	lytic transglycosylase activity
GII78_RS11555	COG2433	Pfam Transposase IS66
GII78_RS11570	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII78_RS11570	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS11585	COG0457	Tetratricopeptide repeat
GII78_RS11590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII78_RS11600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII78_RS11605	COG2226	methyltransferase
GII78_RS11610	COG2211	Major facilitator Superfamily
GII78_RS11615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII78_RS11645	COG5444	nuclease activity
GII78_RS11650	COG4282	regulation of fungal-type cell wall biogenesis
GII78_RS11660	COG1525	nuclease
GII78_RS11670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII78_RS11675	COG1509	lysine 2,3-aminomutase activity
GII78_RS11680	COG0456	acetyltransferase
GII78_RS11685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII78_RS11690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GII78_RS11695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GII78_RS11700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII78_RS11715	COG0456	acetyltransferase
GII78_RS11720	COG0463	Glycosyl transferase, family 2
GII78_RS11735	COG4641	Protein conserved in bacteria
GII78_RS11740	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GII78_RS11745	COG1086	Polysaccharide biosynthesis protein
GII78_RS11750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII78_RS11755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII78_RS11760	COG1846	Transcriptional regulator
GII78_RS11765	COG0534	Mate efflux family protein
GII78_RS11775	COG4698	Protein conserved in bacteria
GII78_RS11780	COG2755	lipolytic protein G-D-S-L family
GII78_RS11785	COG1999	signal sequence binding
GII78_RS11795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GII78_RS11800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII78_RS11805	COG1272	protein, Hemolysin III
GII78_RS11810	COG0204	Acyl-transferase
GII78_RS11815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII78_RS11820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII78_RS11825	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII78_RS11835	COG2136	Putative SAM-dependent methyltransferase
GII78_RS11835	COG2521	methyltransferase
GII78_RS11845	COG0129	dihydroxy-acid dehydratase activity
GII78_RS11850	COG1413	lyase activity
GII78_RS11855	COG1418	mRNA catabolic process
GII78_RS11860	COG0386	Belongs to the glutathione peroxidase family
GII78_RS11865	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GII78_RS11870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII78_RS11880	COG1278	Cold shock
GII78_RS11900	COG0328	RNA-DNA hybrid ribonuclease activity
GII78_RS11905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GII78_RS11910	COG0328	RNA-DNA hybrid ribonuclease activity
GII78_RS11920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII78_RS11935	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII78_RS11945	COG1755	Isoprenylcysteine carboxyl methyltransferase
GII78_RS11950	COG3424	synthase
GII78_RS11955	COG2233	PERMEase
GII78_RS11960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII78_RS11965	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GII78_RS11975	COG0800	Aldolase
GII78_RS11980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII78_RS11985	COG1609	Transcriptional regulator
GII78_RS11990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GII78_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS12000	COG1199	ATP-dependent helicase activity
GII78_RS12015	COG0116	Belongs to the methyltransferase superfamily
GII78_RS12030	COG4474	Belongs to the UPF0398 family
GII78_RS12045	COG3359	exonuclease
GII78_RS12050	COG1205	dead DEAH box helicase
GII78_RS12050	COG1111	helicase
GII78_RS12055	COG2190	(PTS) system
GII78_RS12060	COG0071	Belongs to the small heat shock protein (HSP20) family
GII78_RS12095	COG3331	DNA recombination
GII78_RS12100	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII78_RS12100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII78_RS12110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GII78_RS12115	COG3935	DnaD domain protein
GII78_RS12120	COG0017	Asparaginyl-tRNA synthetase
GII78_RS12125	COG0436	Aminotransferase
GII78_RS12130	COG5353	protein conserved in bacteria
GII78_RS12140	COG1199	ATP-dependent helicase activity
GII78_RS12140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GII78_RS12145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GII78_RS12150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GII78_RS12155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GII78_RS12160	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GII78_RS12160	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GII78_RS12165	COG0617	tRNA 3'-terminal CCA addition
GII78_RS12170	COG0438	transferase activity, transferring glycosyl groups
GII78_RS12175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII78_RS12180	COG1803	Methylglyoxal synthase
GII78_RS12185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GII78_RS12190	COG1694	Mazg nucleotide pyrophosphohydrolase
GII78_RS12195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS12205	COG4347	Protein of unknown function (DUF1405)
GII78_RS12210	COG2010	Cytochrome c
GII78_RS12210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII78_RS12215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII78_RS12220	COG0723	plastoquinol--plastocyanin reductase activity
GII78_RS12230	COG5582	Belongs to the UPF0302 family
GII78_RS12235	COG0457	Tetratricopeptide repeat
GII78_RS12240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GII78_RS12245	COG0287	Prephenate dehydrogenase
GII78_RS12250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GII78_RS12255	COG0159	tryptophan synthase activity
GII78_RS12260	COG0133	tryptophan synthase activity
GII78_RS12265	COG0135	phosphoribosylanthranilate isomerase activity
GII78_RS12275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GII78_RS12280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII78_RS12285	COG4401	Chorismate mutase type I
GII78_RS12290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GII78_RS12295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GII78_RS12300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GII78_RS12305	COG0105	UTP biosynthetic process
GII78_RS12310	COG0142	geranyltranstransferase activity
GII78_RS12315	COG2226	methyltransferase
GII78_RS12320	COG0142	geranyltranstransferase activity
GII78_RS12330	COG0302	gtp cyclohydrolase
GII78_RS12335	COG0776	regulation of translation
GII78_RS12340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII78_RS12355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GII78_RS12360	COG1160	GTP binding
GII78_RS12385	COG1304	FMN binding
GII78_RS12390	COG0539	negative regulation of cytoplasmic translation
GII78_RS12395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GII78_RS12405	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GII78_RS12410	COG2959	enzyme of heme biosynthesis
GII78_RS12415	COG3773	Cell wall hydrolase
GII78_RS12415	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS12420	COG2339	peptidase activity
GII78_RS12425	COG0492	ferredoxin-NADP+ reductase activity
GII78_RS12430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII78_RS12435	COG4862	establishment of competence for transformation
GII78_RS12440	COG1408	metallophosphoesterase
GII78_RS12450	COG1388	LysM domain
GII78_RS12455	COG1266	CAAX protease self-immunity
GII78_RS12460	COG0514	ATP-dependent DNA helicase (RecQ)
GII78_RS12465	COG4955	Helix-turn-helix domain
GII78_RS12470	COG1141	Ferredoxin
GII78_RS12475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GII78_RS12480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GII78_RS12485	COG0710	3-dehydroquinate dehydratase activity
GII78_RS12495	COG1595	DNA-templated transcription, initiation
GII78_RS12500	COG5002	protein histidine kinase activity
GII78_RS12505	COG0745	RESPONSE REGULATOR receiver
GII78_RS12510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII78_RS12515	COG1333	cytochrome c biogenesis protein
GII78_RS12520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS12525	COG1187	pseudouridine synthase activity
GII78_RS12530	COG0700	Nucleoside recognition
GII78_RS12535	COG2715	membrane protein required for spore maturation
GII78_RS12540	COG1686	Belongs to the peptidase S11 family
GII78_RS12550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GII78_RS12555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GII78_RS12560	COG1547	Domain of unknown function (DUF309)
GII78_RS12565	COG0456	acetyltransferase
GII78_RS12570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GII78_RS12575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII78_RS12575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII78_RS12580	COG0307	riboflavin synthase, alpha
GII78_RS12585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII78_RS12585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII78_RS12595	COG0681	Belongs to the peptidase S26 family
GII78_RS12605	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GII78_RS12630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GII78_RS12635	COG4086	secreted protein
GII78_RS12640	COG0019	diaminopimelate decarboxylase activity
GII78_RS12645	COG0697	spore germination
GII78_RS12660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII78_RS12680	COG1191	sigma factor activity
GII78_RS12685	COG2172	sigma factor antagonist activity
GII78_RS12690	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS12695	COG1686	Belongs to the peptidase S11 family
GII78_RS12700	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GII78_RS12705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GII78_RS12710	COG4974	Belongs to the 'phage' integrase family
GII78_RS12720	COG0735	belongs to the Fur family
GII78_RS12725	COG1300	Membrane
GII78_RS12735	COG0281	malic enzyme
GII78_RS12740	COG1757	Na H antiporter
GII78_RS12745	COG1027	Aspartate ammonia-lyase
GII78_RS12750	COG0252	asparaginase activity
GII78_RS12755	COG1396	sequence-specific DNA binding
GII78_RS12760	COG1379	DNA repair
GII78_RS12765	COG0494	nUDIX hydrolase
GII78_RS12775	COG0667	Aldo Keto reductase
GII78_RS12785	COG1073	alpha beta
GII78_RS12795	COG4918	Iron-sulphur cluster biosynthesis
GII78_RS12800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GII78_RS12800	COG0456	acetyltransferase
GII78_RS12805	COG2329	Antibiotic biosynthesis monooxygenase
GII78_RS12810	COG0456	acetyltransferase
GII78_RS12820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII78_RS12830	COG2211	Major facilitator Superfamily
GII78_RS12835	COG0346	lactoylglutathione lyase activity
GII78_RS12840	COG1072	(Pantothenic acid kinase))
GII78_RS12845	COG3048	D-serine ammonia-lyase activity
GII78_RS12850	COG0300	oxidoreductase activity
GII78_RS12855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS12860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII78_RS12865	COG4187	Peptidase family M20/M25/M40
GII78_RS12870	COG1902	pentaerythritol trinitrate reductase activity
GII78_RS12875	COG0596	Alpha beta hydrolase
GII78_RS12885	COG1234	tRNA 3'-trailer cleavage
GII78_RS12890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GII78_RS12895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GII78_RS12900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII78_RS12910	COG0706	membrane insertase activity
GII78_RS12915	COG3361	conserved protein (COG2071)
GII78_RS12920	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII78_RS12925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII78_RS12930	COG0346	lactoylglutathione lyase activity
GII78_RS12940	COG1376	ErfK ybiS ycfS ynhG family protein
GII78_RS12945	COG4129	membrane
GII78_RS12950	COG1126	abc transporter atp-binding protein
GII78_RS12955	COG0765	amino acid transport
GII78_RS12960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS12970	COG1597	lipid kinase activity
GII78_RS12975	COG2814	Major facilitator Superfamily
GII78_RS12980	COG4978	Transcriptional regulator
GII78_RS12980	COG0789	Transcriptional regulator
GII78_RS12985	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII78_RS12990	COG0022	dehydrogenase e1 component
GII78_RS12995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII78_RS13000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII78_RS13005	COG3426	butyrate kinase activity
GII78_RS13010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII78_RS13015	COG0280	phosphate acetyltransferase
GII78_RS13020	COG3290	protein histidine kinase activity
GII78_RS13020	COG3829	transcription factor binding
GII78_RS13030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GII78_RS13035	COG2079	MmgE PrpD family protein
GII78_RS13040	COG0372	Belongs to the citrate synthase family
GII78_RS13045	COG1960	acyl-CoA dehydrogenase activity
GII78_RS13050	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII78_RS13055	COG0183	Belongs to the thiolase family
GII78_RS13060	COG0584	glycerophosphoryl diester phosphodiesterase
GII78_RS13065	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS13080	COG1902	pentaerythritol trinitrate reductase activity
GII78_RS13085	COG0745	RESPONSE REGULATOR receiver
GII78_RS13090	COG0750	zinc metalloprotease
GII78_RS13095	COG0497	DNA recombination
GII78_RS13100	COG1438	arginine binding
GII78_RS13105	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GII78_RS13110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GII78_RS13115	COG0142	geranyltranstransferase activity
GII78_RS13120	COG1722	exodeoxyribonuclease VII activity
GII78_RS13125	COG1570	exodeoxyribonuclease VII activity
GII78_RS13130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GII78_RS13135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII78_RS13140	COG1302	Protein conserved in bacteria
GII78_RS13145	COG0439	Biotin carboxylase
GII78_RS13150	COG0511	ligase activity, forming carbon-carbon bonds
GII78_RS13190	COG3854	ATPases associated with a variety of cellular activities
GII78_RS13200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GII78_RS13205	COG0006	proline dipeptidase activity
GII78_RS13210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GII78_RS13220	COG3872	metal-dependent enzyme
GII78_RS13230	COG1752	Esterase of the alpha-beta hydrolase superfamily
GII78_RS13235	COG1321	iron dependent repressor
GII78_RS13240	COG0095	Lipoate-protein ligase
GII78_RS13245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII78_RS13250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII78_RS13255	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII78_RS13260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GII78_RS13265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII78_RS13280	COG1396	sequence-specific DNA binding
GII78_RS13290	COG0681	Belongs to the peptidase S26 family
GII78_RS13315	COG4940	Competence protein ComGF
GII78_RS13325	COG4970	Tfp pilus assembly protein FimT
GII78_RS13330	COG4537	Required for transformation and DNA binding
GII78_RS13335	COG1459	type II secretion system
GII78_RS13340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GII78_RS13345	COG0517	IMP dehydrogenase activity
GII78_RS13350	COG0598	Magnesium transport protein CorA
GII78_RS13355	COG1253	flavin adenine dinucleotide binding
GII78_RS13360	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS13370	COG1393	Belongs to the ArsC family
GII78_RS13380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS13390	COG0011	TIGRFAM Protein of
GII78_RS13400	COG2866	Carboxypeptidase
GII78_RS13405	COG1368	sulfuric ester hydrolase activity
GII78_RS13410	COG1940	carbohydrate kinase activity
GII78_RS13415	COG4483	Protein conserved in bacteria
GII78_RS13420	COG0457	Tetratricopeptide repeat
GII78_RS13420	COG0705	Rhomboid family
GII78_RS13430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GII78_RS13440	COG0438	transferase activity, transferring glycosyl groups
GII78_RS13455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII78_RS13460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII78_RS13465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII78_RS13470	COG0581	inorganic phosphate transmembrane transporter activity
GII78_RS13475	COG0573	inorganic phosphate transmembrane transporter activity
GII78_RS13480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GII78_RS13485	COG0768	penicillin binding
GII78_RS13490	COG0477	Major facilitator Superfamily
GII78_RS13495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII78_RS13500	COG2839	Protein conserved in bacteria
GII78_RS13505	COG5521	maltodextrose utilization protein MalA
GII78_RS13510	COG1388	LysM domain
GII78_RS13515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GII78_RS13520	COG4709	membrane
GII78_RS13525	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GII78_RS13530	COG0735	belongs to the Fur family
GII78_RS13535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS13545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GII78_RS13550	COG0513	Belongs to the DEAD box helicase family
GII78_RS13560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GII78_RS13565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GII78_RS13570	COG2384	SAM-dependent methyltransferase
GII78_RS13575	COG2010	Cytochrome c
GII78_RS13580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GII78_RS13585	COG0358	DNA primase activity
GII78_RS13590	COG1671	Belongs to the UPF0178 family
GII78_RS13595	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GII78_RS13600	COG0517	IMP dehydrogenase activity
GII78_RS13605	COG0751	glycine-tRNA ligase activity
GII78_RS13610	COG0752	glycyl-tRNA synthetase alpha subunit
GII78_RS13615	COG1381	Involved in DNA repair and RecF pathway recombination
GII78_RS13625	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GII78_RS13630	COG0295	cytidine deaminase activity
GII78_RS13635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GII78_RS13640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GII78_RS13645	COG1480	7TM receptor with intracellular HD hydrolase
GII78_RS13650	COG1702	phosphate starvation-inducible protein PhoH
GII78_RS13655	COG0561	phosphatase activity
GII78_RS13670	COG4864	UPF0365 protein
GII78_RS13675	COG1030	water channel activity
GII78_RS13680	COG1610	YqeY-like protein
GII78_RS13690	COG1283	sodium-dependent phosphate transmembrane transporter activity
GII78_RS13695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII78_RS13700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GII78_RS13705	COG2264	protein methyltransferase activity
GII78_RS13710	COG0484	heat shock protein binding
GII78_RS13715	COG0443	Heat shock 70 kDa protein
GII78_RS13720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GII78_RS13725	COG1420	regulation of RNA biosynthetic process
GII78_RS13730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII78_RS13735	COG0481	GTPase activity
GII78_RS13745	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS13750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GII78_RS13755	COG0268	Binds directly to 16S ribosomal RNA
GII78_RS13760	COG1466	dna polymerase III delta subunit
GII78_RS13775	COG2333	competence protein COMEC
GII78_RS13775	COG0658	competence protein
GII78_RS13780	COG2131	deaminase
GII78_RS13785	COG1555	photosystem II stabilization
GII78_RS13785	COG1596	polysaccharide export
GII78_RS13790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII78_RS13795	COG2226	methyltransferase
GII78_RS13800	COG0799	negative regulation of ribosome biogenesis
GII78_RS13805	COG1713	HD superfamily hydrolase involved in NAD metabolism
GII78_RS13810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GII78_RS13815	COG1534	Rna-binding protein
GII78_RS13820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GII78_RS13825	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII78_RS13830	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GII78_RS13840	COG2755	lipolytic protein G-D-S-L family
GII78_RS13845	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS13845	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII78_RS13850	COG0398	Pfam SNARE associated Golgi protein
GII78_RS13865	COG3209	COG3209 Rhs family protein
GII78_RS13875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII78_RS13880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII78_RS13885	COG0798	PFAM Bile acid sodium symporter
GII78_RS13890	COG0346	lactoylglutathione lyase activity
GII78_RS13895	COG0640	Transcriptional regulator
GII78_RS13900	COG3403	YqcI/YcgG family
GII78_RS13920	COG0604	alcohol dehydrogenase
GII78_RS13945	COG0457	Tetratricopeptide repeat
GII78_RS13960	COG5444	nuclease activity
GII78_RS13985	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS13985	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII78_RS13990	COG4824	toxin secretion phage lysis holin
GII78_RS14020	COG3778	Protein conserved in bacteria
GII78_RS14025	COG3299	homolog of phage Mu protein gp47
GII78_RS14030	COG3628	GPW Gp25 family protein
GII78_RS14040	COG4193	domain, Protein
GII78_RS14045	COG1652	LysM domain
GII78_RS14050	COG3953	SLT domain
GII78_RS14050	COG5280	Phage tail tape measure protein TP901
GII78_RS14110	COG4653	Phage capsid family
GII78_RS14115	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII78_RS14125	COG2369	cell adhesion
GII78_RS14130	COG5518	Phage portal protein
GII78_RS14135	COG1783	phage Terminase large subunit
GII78_RS14140	COG5484	DNA packaging
GII78_RS14150	COG3677	Transposase
GII78_RS14165	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GII78_RS14175	COG1484	DNA-dependent DNA replication
GII78_RS14180	COG3935	DnaD domain protein
GII78_RS14185	COG3723	Recombinational DNA repair protein, rece pathway
GII78_RS14190	COG5377	YqaJ viral recombinase family
GII78_RS14225	COG3620	sequence-specific DNA binding
GII78_RS14235	COG0563	adenylate kinase activity
GII78_RS14240	COG2856	Zn peptidase
GII78_RS14255	COG5002	protein histidine kinase activity
GII78_RS14255	COG0642	Histidine kinase
GII78_RS14260	COG0745	RESPONSE REGULATOR receiver
GII78_RS14265	COG2311	Membrane
GII78_RS14275	COG0454	-acetyltransferase
GII78_RS14280	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII78_RS14290	COG0730	response to heat
GII78_RS14295	COG0425	Belongs to the sulfur carrier protein TusA family
GII78_RS14300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS14300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII78_RS14310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII78_RS14310	COG0425	Belongs to the sulfur carrier protein TusA family
GII78_RS14320	COG2210	Belongs to the sulfur carrier protein TusA family
GII78_RS14325	COG1937	Protein conserved in bacteria
GII78_RS14330	COG0662	Cupin 2, conserved barrel domain protein
GII78_RS14340	COG0789	Transcriptional regulator
GII78_RS14340	COG4978	Transcriptional regulator
GII78_RS14345	COG2814	Major facilitator Superfamily
GII78_RS14350	COG0456	acetyltransferase
GII78_RS14355	COG1253	flavin adenine dinucleotide binding
GII78_RS14365	COG0697	spore germination
GII78_RS14370	COG0583	DNA-binding transcription factor activity
GII78_RS14375	COG2072	flavoprotein involved in K transport
GII78_RS14380	COG1230	cation diffusion facilitator family transporter
GII78_RS14390	COG1114	Component of the transport system for branched-chain amino acids
GII78_RS14395	COG1687	branched-chain amino acid
GII78_RS14400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GII78_RS14405	COG1522	sequence-specific DNA binding
GII78_RS14415	COG2124	cytochrome p450
GII78_RS14425	COG1335	isochorismatase
GII78_RS14435	COG2318	DinB family
GII78_RS14445	COG2070	2-Nitropropane dioxygenase
GII78_RS14450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GII78_RS14460	COG2186	Transcriptional regulator
GII78_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS14480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GII78_RS14485	COG3959	Transketolase, thiamine diphosphate binding domain
GII78_RS14495	COG4978	Transcriptional regulator
GII78_RS14495	COG0789	Transcriptional regulator
GII78_RS14500	COG2315	Protein conserved in bacteria
GII78_RS14510	COG3443	Belongs to the bacterial solute-binding protein 9 family
GII78_RS14515	COG1595	DNA-templated transcription, initiation
GII78_RS14520	COG0667	Aldo Keto reductase
GII78_RS14525	COG2851	Citrate transporter
GII78_RS14530	COG0583	DNA-binding transcription factor activity
GII78_RS14535	COG2828	Protein conserved in bacteria
GII78_RS14540	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS14545	COG5566	PFAM Mor transcription activator
GII78_RS14550	COG0596	Alpha beta hydrolase
GII78_RS14555	COG4991	sh3 domain protein
GII78_RS14560	COG4991	sh3 domain protein
GII78_RS14570	COG0346	lactoylglutathione lyase activity
GII78_RS14580	COG5577	PFAM Coat F domain
GII78_RS14585	COG1063	alcohol dehydrogenase
GII78_RS14595	COG5577	PFAM Coat F domain
GII78_RS14600	COG0789	Transcriptional regulator
GII78_RS14610	COG1064	alcohol dehydrogenase
GII78_RS14615	COG0693	protein deglycase activity
GII78_RS14620	COG1621	beta-fructofuranosidase activity
GII78_RS14625	COG3716	PTS system mannose fructose sorbose family IID component
GII78_RS14630	COG3715	PTS system
GII78_RS14635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS14640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS14645	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII78_RS14645	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GII78_RS14655	COG1113	amino acid transport
GII78_RS14660	COG1280	lysine exporter protein (LysE YggA)
GII78_RS14665	COG1378	Sugar-specific transcriptional regulator TrmB
GII78_RS14670	COG1595	DNA-templated transcription, initiation
GII78_RS14690	COG2124	cytochrome p450
GII78_RS14690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII78_RS14695	COG1309	transcriptional regulator
GII78_RS14700	COG2226	methyltransferase
GII78_RS14715	COG2116	formate transmembrane transporter activity
GII78_RS14720	COG5609	conserved protein (DUF2294)
GII78_RS14725	COG3383	formate dehydrogenase (NAD+) activity
GII78_RS14730	COG2427	Protein of unknown function (DUF1641)
GII78_RS14740	COG0626	cystathionine gamma-synthase activity
GII78_RS14745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII78_RS14750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GII78_RS14755	COG2226	methyltransferase
GII78_RS14770	COG0768	penicillin binding
GII78_RS14775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GII78_RS14780	COG0572	uridine kinase
GII78_RS14785	COG0826	peptidase U32
GII78_RS14790	COG0826	peptidase U32
GII78_RS14795	COG4122	O-methyltransferase activity
GII78_RS14800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII78_RS14805	COG3906	Belongs to the UPF0473 family
GII78_RS14810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GII78_RS14815	COG4472	Bacterial protein of unknown function (DUF965)
GII78_RS14820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GII78_RS14825	COG0628	permease
GII78_RS14830	COG1126	abc transporter atp-binding protein
GII78_RS14835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS14840	COG0765	amino acid transport
GII78_RS14845	COG0765	amino acid transport
GII78_RS14860	COG3881	PFAM PRC-barrel domain
GII78_RS14865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GII78_RS14870	COG0457	Tetratricopeptide repeat
GII78_RS14875	COG0482	sulfurtransferase activity
GII78_RS14880	COG1104	cysteine desulfurase activity
GII78_RS14885	COG1959	2 iron, 2 sulfur cluster binding
GII78_RS14890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GII78_RS14895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GII78_RS14905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GII78_RS14910	COG0124	histidyl-tRNA synthetase
GII78_RS14920	COG4991	sh3 domain protein
GII78_RS14920	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS14920	COG3103	Sh3 type 3 domain protein
GII78_RS14925	COG1490	D-aminoacyl-tRNA deacylase activity
GII78_RS14930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GII78_RS14935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII78_RS14940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GII78_RS14940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII78_RS14945	COG5416	Lipopolysaccharide assembly protein A domain
GII78_RS14950	COG0490	domain, Protein
GII78_RS14955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII78_RS14955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII78_RS14965	COG2244	polysaccharide biosynthetic process
GII78_RS14970	COG2323	membrane
GII78_RS14980	COG1862	Preprotein translocase
GII78_RS14985	COG0343	queuine tRNA-ribosyltransferase activity
GII78_RS14990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GII78_RS15000	COG2255	four-way junction helicase activity
GII78_RS15005	COG0632	four-way junction helicase activity
GII78_RS15015	COG2814	Major facilitator Superfamily
GII78_RS15020	COG0673	inositol 2-dehydrogenase activity
GII78_RS15025	COG2112	serine threonine protein kinase
GII78_RS15045	COG1115	amino acid carrier protein
GII78_RS15050	COG0217	transcriptional regulatory protein
GII78_RS15060	COG1388	LysM domain
GII78_RS15065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GII78_RS15070	COG0157	Belongs to the NadC ModD family
GII78_RS15075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GII78_RS15080	COG1104	cysteine desulfurase activity
GII78_RS15085	COG1827	regulation of RNA biosynthetic process
GII78_RS15090	COG0077	Prephenate dehydratase
GII78_RS15095	COG4492	Belongs to the UPF0735 family
GII78_RS15100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GII78_RS15105	COG3290	protein histidine kinase activity
GII78_RS15115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GII78_RS15120	COG2868	ribosomal protein
GII78_RS15125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GII78_RS15130	COG1994	Peptidase M50
GII78_RS15135	COG0739	heme binding
GII78_RS15140	COG2894	cell division
GII78_RS15145	COG0850	regulation of cytokinetic process
GII78_RS15150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GII78_RS15160	COG1077	Cell shape determining protein MreB Mrl
GII78_RS15165	COG2003	Belongs to the UPF0758 family
GII78_RS15170	COG0424	maF-like protein
GII78_RS15180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GII78_RS15185	COG0285	dihydrofolate synthase activity
GII78_RS15190	COG0525	valine-tRNA ligase activity
GII78_RS15200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII78_RS15205	COG1388	LysM domain
GII78_RS15210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII78_RS15215	COG0113	porphobilinogen synthase activity
GII78_RS15220	COG1587	Uroporphyrinogen-III synthase
GII78_RS15225	COG0181	hydroxymethylbilane synthase activity
GII78_RS15230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII78_RS15235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GII78_RS15245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GII78_RS15250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GII78_RS15255	COG1067	ATP-dependent peptidase activity
GII78_RS15255	COG0470	DNA polymerase III
GII78_RS15260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GII78_RS15265	COG0544	peptidyl-prolyl cis-trans isomerase activity
GII78_RS15270	COG0457	Tetratricopeptide repeat
GII78_RS15270	COG1477	protein flavinylation
GII78_RS15275	COG0066	3-isopropylmalate dehydratase activity
GII78_RS15280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GII78_RS15285	COG0473	3-isopropylmalate dehydrogenase activity
GII78_RS15290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII78_RS15295	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GII78_RS15300	COG0440	acetolactate synthase activity
GII78_RS15305	COG0028	Belongs to the TPP enzyme family
GII78_RS15315	COG0454	-acetyltransferase
GII78_RS15320	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GII78_RS15330	COG0622	Phosphoesterase
GII78_RS15335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GII78_RS15340	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GII78_RS15345	COG5401	PFAM Sporulation and spore germination
GII78_RS15350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GII78_RS15355	COG1846	Transcriptional regulator
GII78_RS15360	COG2197	response regulator
GII78_RS15365	COG0824	Thioesterase
GII78_RS15370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GII78_RS15375	COG1053	succinate dehydrogenase
GII78_RS15380	COG2009	succinate dehydrogenase
GII78_RS15385	COG1719	4-vinyl reductase, 4VR
GII78_RS15390	COG0527	aspartate kinase activity
GII78_RS15395	COG0322	excinuclease ABC activity
GII78_RS15400	COG3118	belongs to the thioredoxin family
GII78_RS15405	COG3534	alpha-L-arabinofuranosidase
GII78_RS15410	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GII78_RS15415	COG2086	electron transfer activity
GII78_RS15420	COG1024	Enoyl-CoA hydratase
GII78_RS15425	COG1309	transcriptional regulator
GII78_RS15430	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS15435	COG3766	membrane
GII78_RS15440	COG1193	negative regulation of DNA recombination
GII78_RS15445	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII78_RS15445	COG1796	DNA polymerase
GII78_RS15450	COG1286	toxin biosynthetic process
GII78_RS15455	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GII78_RS15460	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII78_RS15465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII78_RS15465	COG0072	phenylalanine-tRNA ligase activity
GII78_RS15470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GII78_RS15480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII78_RS15490	COG3835	regulator
GII78_RS15495	COG0277	FAD linked oxidase domain protein
GII78_RS15500	COG0247	lactate metabolic process
GII78_RS15505	COG0346	lactoylglutathione lyase activity
GII78_RS15515	COG1966	Carbon starvation protein
GII78_RS15520	COG3534	alpha-L-arabinofuranosidase
GII78_RS15525	COG0395	ABC-type sugar transport system, permease component
GII78_RS15530	COG1175	transmembrane transport
GII78_RS15535	COG1653	transport
GII78_RS15540	COG0371	Dehydrogenase
GII78_RS15545	COG0647	UMP catabolic process
GII78_RS15550	COG0235	Class ii aldolase
GII78_RS15555	COG1069	ribulokinase activity
GII78_RS15560	COG2160	L-arabinose isomerase activity
GII78_RS15565	COG3507	Belongs to the glycosyl hydrolase 43 family
GII78_RS15570	COG1363	Peptidase, m42
GII78_RS15580	COG3326	Membrane
GII78_RS15585	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GII78_RS15590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GII78_RS15595	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GII78_RS15605	COG1346	cytolysis
GII78_RS15610	COG1380	Effector of murein hydrolase LrgA
GII78_RS15615	COG3279	Response regulator of the LytR AlgR family
GII78_RS15620	COG3275	phosphorelay sensor kinase activity
GII78_RS15625	COG1011	Hydrolase
GII78_RS15630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII78_RS15640	COG0398	Pfam SNARE associated Golgi protein
GII78_RS15645	COG1484	DNA-dependent DNA replication
GII78_RS15650	COG3611	Membrane attachment protein
GII78_RS15655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GII78_RS15660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GII78_RS15665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII78_RS15670	COG1733	regulation of RNA biosynthetic process
GII78_RS15675	COG2814	Major facilitator Superfamily
GII78_RS15680	COG0656	L-ascorbic acid biosynthetic process
GII78_RS15685	COG0237	dephospho-CoA kinase activity
GII78_RS15690	COG1971	Probably functions as a manganese efflux pump
GII78_RS15695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GII78_RS15700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII78_RS15700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII78_RS15705	COG5002	protein histidine kinase activity
GII78_RS15710	COG0745	RESPONSE REGULATOR receiver
GII78_RS15715	COG0039	L-malate dehydrogenase activity
GII78_RS15720	COG0538	isocitrate dehydrogenase activity
GII78_RS15725	COG0372	Belongs to the citrate synthase family
GII78_RS15730	COG2707	UPF0756 membrane protein
GII78_RS15735	COG0628	permease
GII78_RS15740	COG3030	protein affecting phage T7 exclusion by the F plasmid
GII78_RS15745	COG0469	pyruvate kinase activity
GII78_RS15750	COG0205	6-phosphofructokinase activity
GII78_RS15755	COG0825	malonyl-CoA metabolic process
GII78_RS15760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GII78_RS15765	COG0281	malic enzyme
GII78_RS15770	COG0587	DNA-directed DNA polymerase activity
GII78_RS15790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GII78_RS15800	COG4109	DRTGG domain
GII78_RS15805	COG0730	response to heat
GII78_RS15810	COG1473	amidohydrolase
GII78_RS15815	COG0196	riboflavin kinase activity
GII78_RS15820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS15825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GII78_RS15830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS15835	COG1126	abc transporter atp-binding protein
GII78_RS15840	COG0765	amino acid transport
GII78_RS15845	COG0765	amino acid transport
GII78_RS15850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS15855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS15860	COG0454	-acetyltransferase
GII78_RS15865	COG0583	DNA-binding transcription factor activity
GII78_RS15870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GII78_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS15885	COG0165	Argininosuccinate lyase
GII78_RS15890	COG0137	argininosuccinate synthase activity
GII78_RS15895	COG0521	Mo-molybdopterin cofactor biosynthetic process
GII78_RS15900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GII78_RS15910	COG0827	DNA restriction-modification system
GII78_RS15915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GII78_RS15920	COG3874	Sporulation protein YtfJ
GII78_RS15930	COG1714	RDD family
GII78_RS15935	COG0616	signal peptide processing
GII78_RS15940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII78_RS15945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GII78_RS15950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII78_RS15960	COG0301	tRNA thio-modification
GII78_RS15965	COG1104	cysteine desulfurase activity
GII78_RS15970	COG1114	Component of the transport system for branched-chain amino acids
GII78_RS15975	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GII78_RS15980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII78_RS15985	COG1309	transcriptional regulator
GII78_RS15990	COG1956	GAF domain-containing protein
GII78_RS15995	COG2199	diguanylate cyclase activity
GII78_RS15995	COG2203	Gaf domain
GII78_RS16005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GII78_RS16010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII78_RS16015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII78_RS16020	COG0454	-acetyltransferase
GII78_RS16025	COG0517	IMP dehydrogenase activity
GII78_RS16030	COG0123	including yeast histone deacetylase and acetoin utilization protein
GII78_RS16035	COG1360	Flagellar Motor Protein
GII78_RS16040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII78_RS16045	COG1609	Transcriptional regulator
GII78_RS16050	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GII78_RS16050	COG1605	Chorismate mutase
GII78_RS16055	COG3118	belongs to the thioredoxin family
GII78_RS16060	COG4980	gas vesicle protein
GII78_RS16065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GII78_RS16070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GII78_RS16075	COG1674	ftsk spoiiie
GII78_RS16080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII78_RS16085	COG4848	Belongs to the UPF0354 family
GII78_RS16090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS16105	COG1363	Peptidase, m42
GII78_RS16110	COG5584	Small secreted protein
GII78_RS16115	COG0281	malic enzyme
GII78_RS16120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS16125	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GII78_RS16135	COG0510	thiamine kinase activity
GII78_RS16140	COG1523	belongs to the glycosyl hydrolase 13 family
GII78_RS16145	COG1597	lipid kinase activity
GII78_RS16155	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII78_RS16160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII78_RS16165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII78_RS16170	COG2252	PERMEase
GII78_RS16175	COG4473	ABC transporter
GII78_RS16180	COG1131	(ABC) transporter
GII78_RS16185	COG1349	DNA-binding transcription factor activity
GII78_RS16190	COG1187	pseudouridine synthase activity
GII78_RS16195	COG2244	polysaccharide biosynthetic process
GII78_RS16200	COG2081	HI0933 family
GII78_RS16205	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GII78_RS16215	COG5578	integral membrane protein
GII78_RS16220	COG0673	inositol 2-dehydrogenase activity
GII78_RS16225	COG1653	transport
GII78_RS16230	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII78_RS16235	COG4209	transmembrane transport
GII78_RS16240	COG2207	Transcriptional regulator
GII78_RS16245	COG1653	transport
GII78_RS16250	COG0395	ABC-type sugar transport system, permease component
GII78_RS16255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII78_RS16260	COG2124	cytochrome p450
GII78_RS16265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GII78_RS16275	COG0156	8-amino-7-oxononanoate synthase activity
GII78_RS16280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII78_RS16290	COG1073	alpha beta
GII78_RS16295	COG1609	Transcriptional regulator
GII78_RS16300	COG1653	transport
GII78_RS16305	COG1175	transmembrane transport
GII78_RS16310	COG0395	ABC-type sugar transport system, permease component
GII78_RS16315	COG1486	melibiose metabolic process
GII78_RS16320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII78_RS16325	COG0495	leucyl-tRNA aminoacylation
GII78_RS16335	COG1366	Belongs to the anti-sigma-factor antagonist family
GII78_RS16335	COG2202	Pas domain
GII78_RS16340	COG2814	Major facilitator Superfamily
GII78_RS16345	COG2433	Pfam Transposase IS66
GII78_RS16350	COG0577	efflux transmembrane transporter activity
GII78_RS16355	COG1136	(ABC) transporter
GII78_RS16360	COG2205	protein histidine kinase activity
GII78_RS16365	COG0745	RESPONSE REGULATOR receiver
GII78_RS16370	COG0577	efflux transmembrane transporter activity
GII78_RS16375	COG1136	(ABC) transporter
GII78_RS16390	COG1131	(ABC) transporter
GII78_RS16395	COG1725	Transcriptional regulator
GII78_RS16410	COG1242	4 iron, 4 sulfur cluster binding
GII78_RS16415	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GII78_RS16425	COG2267	carboxylic ester hydrolase activity
GII78_RS16430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GII78_RS16435	COG1113	amino acid transport
GII78_RS16440	COG0367	asparagine synthase
GII78_RS16445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GII78_RS16450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GII78_RS16460	COG1506	peptidase
GII78_RS16465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII78_RS16470	COG1116	anion transmembrane transporter activity
GII78_RS16475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII78_RS16480	COG0494	nUDIX hydrolase
GII78_RS16485	COG4824	toxin secretion phage lysis holin
GII78_RS16490	COG0783	Belongs to the Dps family
GII78_RS16505	COG1854	S-ribosylhomocysteine lyase activity
GII78_RS16510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GII78_RS16515	COG0288	reversible hydration of carbon dioxide
GII78_RS16520	COG0254	rRNA binding
GII78_RS16525	COG1271	oxidase subunit
GII78_RS16530	COG1294	oxidase, subunit
GII78_RS16540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII78_RS16545	COG1321	iron dependent repressor
GII78_RS16545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII78_RS16550	COG1121	(ABC) transporter
GII78_RS16555	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII78_RS16560	COG4948	Mandelate Racemase Muconate Lactonizing
GII78_RS16565	COG0318	PFAM AMP-dependent synthetase and ligase
GII78_RS16570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GII78_RS16575	COG0596	Alpha beta hydrolase
GII78_RS16580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GII78_RS16585	COG1169	isochorismate synthase
GII78_RS16590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII78_RS16595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII78_RS16600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII78_RS16605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII78_RS16610	COG0438	transferase activity, transferring glycosyl groups
GII78_RS16620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII78_RS16625	COG0438	transferase activity, transferring glycosyl groups
GII78_RS16630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII78_RS16635	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GII78_RS16640	COG0058	SHG alpha-glucan phosphorylase activity
GII78_RS16645	COG0297	glycogen (starch) synthase activity
GII78_RS16650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII78_RS16655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII78_RS16660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GII78_RS16785	COG3859	Proton-coupled thiamine transporter YuaJ
GII78_RS16790	COG1247	-acetyltransferase
GII78_RS16795	COG2268	Band 7 protein
GII78_RS16800	COG1585	Membrane protein implicated in regulation of membrane protease activity
GII78_RS16805	COG2318	DinB family
GII78_RS16815	COG1454	alcohol dehydrogenase
GII78_RS16820	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS16825	COG1510	regulation of RNA biosynthetic process
GII78_RS16835	COG0569	domain protein
GII78_RS16840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII78_RS16845	COG4682	membrane
GII78_RS16850	COG1705	Flagellar rod assembly protein muramidase FlgJ
GII78_RS16855	COG0477	Major facilitator Superfamily
GII78_RS16860	COG5553	Cysteine dioxygenase type I
GII78_RS16870	COG1968	undecaprenyl-diphosphatase activity
GII78_RS16875	COG0628	permease
GII78_RS16880	COG0673	inositol 2-dehydrogenase activity
GII78_RS16885	COG4806	L-rhamnose isomerase
GII78_RS16890	COG3254	rhamnose metabolic process
GII78_RS16895	COG1070	Carbohydrate kinase
GII78_RS16900	COG1349	DNA-binding transcription factor activity
GII78_RS16905	COG3347	Dehydrogenase
GII78_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS16910	COG0840	transmembrane signaling receptor activity
GII78_RS16915	COG0840	transmembrane signaling receptor activity
GII78_RS16920	COG0840	transmembrane signaling receptor activity
GII78_RS16925	COG0840	transmembrane signaling receptor activity
GII78_RS16940	COG0432	Pfam Uncharacterised protein family UPF0047
GII78_RS16950	COG0366	Alpha amylase catalytic
GII78_RS16955	COG1253	flavin adenine dinucleotide binding
GII78_RS16960	COG2738	Putative neutral zinc metallopeptidase
GII78_RS16975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GII78_RS16990	COG0166	Belongs to the GPI family
GII78_RS16995	COG1979	alcohol dehydrogenase
GII78_RS17000	COG1979	alcohol dehydrogenase
GII78_RS17005	COG2155	Conserved Protein
GII78_RS17010	COG1098	S1 RNA binding domain
GII78_RS17015	COG0436	Aminotransferase
GII78_RS17020	COG1522	sequence-specific DNA binding
GII78_RS17025	COG2267	carboxylic ester hydrolase activity
GII78_RS17035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GII78_RS17040	COG2205	protein histidine kinase activity
GII78_RS17050	COG5018	Exonuclease
GII78_RS17060	COG2814	Major facilitator Superfamily
GII78_RS17065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII78_RS17070	COG3011	Protein conserved in bacteria
GII78_RS17080	COG3290	protein histidine kinase activity
GII78_RS17085	COG4565	transcriptional regulatory protein
GII78_RS17090	COG1744	ABC transporter substrate-binding protein PnrA-like
GII78_RS17095	COG3845	ABC transporter
GII78_RS17100	COG4603	Belongs to the binding-protein-dependent transport system permease family
GII78_RS17105	COG1079	Belongs to the binding-protein-dependent transport system permease family
GII78_RS17110	COG3493	citrate carrier protein
GII78_RS17120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII78_RS17120	COG2111	Na H antiporter
GII78_RS17125	COG2111	Na H antiporter
GII78_RS17130	COG1006	Multisubunit Na H antiporter MnhC subunit
GII78_RS17135	COG0651	ATP synthesis coupled electron transport
GII78_RS17140	COG1863	multisubunit Na H antiporter MnhE subunit
GII78_RS17145	COG2212	antiporter activity
GII78_RS17150	COG1320	monovalent cation:proton antiporter activity
GII78_RS17155	COG2050	protein possibly involved in aromatic compounds catabolism
GII78_RS17160	COG2197	response regulator
GII78_RS17165	COG4585	Histidine kinase
GII78_RS17175	COG0142	geranyltranstransferase activity
GII78_RS17195	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GII78_RS17200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GII78_RS17205	COG1335	isochorismatase
GII78_RS17210	COG5506	Protein of unknown function (DUF1694)
GII78_RS17225	COG0628	permease
GII78_RS17240	COG1418	mRNA catabolic process
GII78_RS17245	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS17255	COG1511	domain protein
GII78_RS17260	COG0433	COG0433 Predicted ATPase
GII78_RS17260	COG1674	ftsk spoiiie
GII78_RS17265	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII78_RS17270	COG5417	Belongs to the EsaB family
GII78_RS17275	COG4842	Belongs to the WXG100 family
GII78_RS17280	COG2508	Transcriptional regulator
GII78_RS17280	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII78_RS17285	COG0686	Belongs to the AlaDH PNT family
GII78_RS17290	COG5634	Uncharacterized conserved protein (DUF2278)
GII78_RS17295	COG3251	PFAM MbtH domain protein
GII78_RS17300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS17305	COG3433	isochorismatase activity
GII78_RS17305	COG1535	isochorismatase
GII78_RS17310	COG1021	2,3-dihydroxybenzoate-AMP ligase
GII78_RS17315	COG1169	isochorismate synthase
GII78_RS17320	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS17325	COG2819	hydrolase of the alpha beta superfamily
GII78_RS17330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII78_RS17335	COG1268	BioY protein
GII78_RS17340	COG2056	Na+-H+ antiporter family
GII78_RS17345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GII78_RS17350	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GII78_RS17355	COG3584	3D domain protein
GII78_RS17370	COG1252	NADH dehydrogenase
GII78_RS17375	COG0492	ferredoxin-NADP+ reductase activity
GII78_RS17385	COG0516	GMP reductase activity
GII78_RS17390	COG2808	Putative FMN-binding domain
GII78_RS17395	COG0456	acetyltransferase
GII78_RS17400	COG0316	Belongs to the HesB IscA family
GII78_RS17405	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GII78_RS17410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII78_RS17415	COG4844	belongs to the
GII78_RS17420	COG1252	NADH dehydrogenase
GII78_RS17425	COG4837	Protein of unknown function (DUF1462)
GII78_RS17430	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GII78_RS17435	COG4946	Tricorn protease homolog
GII78_RS17435	COG0823	Involved in the tonB-independent uptake of proteins
GII78_RS17435	COG1506	peptidase
GII78_RS17440	COG0083	homoserine kinase activity
GII78_RS17445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GII78_RS17450	COG0460	homoserine dehydrogenase
GII78_RS17455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII78_RS17460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII78_RS17465	COG0647	UMP catabolic process
GII78_RS17470	COG2445	Protein of unknown function DUF86
GII78_RS17475	COG4470	Protein conserved in bacteria
GII78_RS17485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GII78_RS17490	COG0739	heme binding
GII78_RS17500	COG3377	Domain of unknown function (DUF1805)
GII78_RS17505	COG0737	Belongs to the 5'-nucleotidase family
GII78_RS17510	COG0730	response to heat
GII78_RS17515	COG1801	Protein of unknown function DUF72
GII78_RS17525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII78_RS17530	COG2508	Transcriptional regulator
GII78_RS17535	COG2233	PERMEase
GII78_RS17540	COG2233	PERMEase
GII78_RS17545	COG3648	Uricase
GII78_RS17545	COG3195	allantoin biosynthetic process
GII78_RS17550	COG2351	hydroxyisourate hydrolase activity
GII78_RS17560	COG2080	2 iron, 2 sulfur cluster binding
GII78_RS17565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GII78_RS17570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GII78_RS17575	COG2068	MobA-Related Protein
GII78_RS17580	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GII78_RS17585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GII78_RS17590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII78_RS17600	COG2356	endonuclease I
GII78_RS17605	COG3842	ATPase activity
GII78_RS17610	COG2188	Transcriptional regulator
GII78_RS17615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII78_RS17620	COG0395	ABC-type sugar transport system, permease component
GII78_RS17625	COG1175	transmembrane transport
GII78_RS17630	COG1653	transport
GII78_RS17635	COG2222	sugar isomerase
GII78_RS17640	COG0322	excinuclease ABC activity
GII78_RS17645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII78_RS17660	COG0719	Fe-S assembly protein
GII78_RS17665	COG0822	iron-sulfur transferase activity
GII78_RS17670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII78_RS17675	COG0719	Fe-S assembly protein
GII78_RS17680	COG0396	ATPase activity
GII78_RS17690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII78_RS17695	COG1464	Belongs to the NlpA lipoprotein family
GII78_RS17700	COG2011	ABC-type metal ion transport system permease component
GII78_RS17705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GII78_RS17715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII78_RS17720	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII78_RS17730	COG0509	glycine decarboxylation via glycine cleavage system
GII78_RS17735	COG1393	Belongs to the ArsC family
GII78_RS17740	COG1960	acyl-CoA dehydrogenase activity
GII78_RS17745	COG0183	Belongs to the thiolase family
GII78_RS17750	COG1024	Enoyl-CoA hydratase
GII78_RS17750	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII78_RS17760	COG0506	proline dehydrogenase activity
GII78_RS17770	COG5577	PFAM Coat F domain
GII78_RS17775	COG1846	Transcriptional regulator
GII78_RS17780	COG0477	Major facilitator Superfamily
GII78_RS17785	COG1942	4-Oxalocrotonate Tautomerase
GII78_RS17790	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS17795	COG0583	DNA-binding transcription factor activity
GII78_RS17805	COG1120	ATPase activity
GII78_RS17820	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS17825	COG0783	Belongs to the Dps family
GII78_RS17830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII78_RS17835	COG0745	RESPONSE REGULATOR receiver
GII78_RS17840	COG2770	Histidine kinase
GII78_RS17840	COG2205	protein histidine kinase activity
GII78_RS17850	COG1309	transcriptional regulator
GII78_RS17855	COG0114	fumarate hydratase activity
GII78_RS17865	COG0697	spore germination
GII78_RS17870	COG0814	amino acid
GII78_RS17880	COG2197	response regulator
GII78_RS17885	COG4585	Histidine kinase
GII78_RS17890	COG4758	membrane
GII78_RS17895	COG3595	metallopeptidase activity
GII78_RS17900	COG1842	Phage shock protein A
GII78_RS17905	COG4758	membrane
GII78_RS17910	COG2814	Major facilitator Superfamily
GII78_RS17915	COG2096	Adenosyltransferase
GII78_RS17920	COG1120	ATPase activity
GII78_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS17930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS17940	COG3386	PFAM SMP-30 Gluconolaconase
GII78_RS17945	COG2205	protein histidine kinase activity
GII78_RS17950	COG0745	RESPONSE REGULATOR receiver
GII78_RS17960	COG1191	sigma factor activity
GII78_RS17970	COG2140	Oxalate decarboxylase
GII78_RS17980	COG0577	efflux transmembrane transporter activity
GII78_RS17985	COG1136	(ABC) transporter
GII78_RS17990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GII78_RS17995	COG1120	ATPase activity
GII78_RS18000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS18005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII78_RS18010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS18015	COG0531	amino acid
GII78_RS18025	COG1988	membrane-bound metal-dependent
GII78_RS18030	COG1368	sulfuric ester hydrolase activity
GII78_RS18035	COG1910	domain protein
GII78_RS18040	COG0725	ABC transporter, periplasmic molybdate-binding protein
GII78_RS18045	COG4149	molybdate abc transporter
GII78_RS18050	COG0656	L-ascorbic acid biosynthetic process
GII78_RS18060	COG0025	NhaP-type Na H and K H
GII78_RS18065	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII78_RS18070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII78_RS18075	COG3973	AAA domain
GII78_RS18085	COG2860	membrane
GII78_RS18090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GII78_RS18095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GII78_RS18100	COG2217	Heavy metal translocating P-type atpase
GII78_RS18105	COG2217	Heavy metal translocating P-type atpase
GII78_RS18110	COG2608	mercury ion transmembrane transporter activity
GII78_RS18115	COG1937	Protein conserved in bacteria
GII78_RS18120	COG0673	inositol 2-dehydrogenase activity
GII78_RS18125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII78_RS18130	COG1289	transmembrane transporter activity
GII78_RS18140	COG2076	Multidrug Resistance protein
GII78_RS18145	COG1309	transcriptional regulator
GII78_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS18160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GII78_RS18165	COG0557	exoribonuclease II activity
GII78_RS18170	COG1647	Serine aminopeptidase, S33
GII78_RS18175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GII78_RS18180	COG0596	Alpha beta hydrolase
GII78_RS18185	COG1476	TRANSCRIPTIONal
GII78_RS18190	COG1396	sequence-specific DNA binding
GII78_RS18195	COG1396	sequence-specific DNA binding
GII78_RS18200	COG1733	regulation of RNA biosynthetic process
GII78_RS18205	COG0840	transmembrane signaling receptor activity
GII78_RS18210	COG1174	glycine betaine transport
GII78_RS18215	COG1732	Glycine betaine
GII78_RS18220	COG1174	glycine betaine transport
GII78_RS18225	COG0517	IMP dehydrogenase activity
GII78_RS18225	COG1125	glycine betaine transport
GII78_RS18230	COG1510	regulation of RNA biosynthetic process
GII78_RS18235	COG1174	glycine betaine transport
GII78_RS18240	COG1732	Glycine betaine
GII78_RS18245	COG1174	glycine betaine transport
GII78_RS18250	COG0517	IMP dehydrogenase activity
GII78_RS18250	COG1125	glycine betaine transport
GII78_RS18255	COG1510	regulation of RNA biosynthetic process
GII78_RS18260	COG2095	MarC family integral membrane protein
GII78_RS18270	COG3064	Membrane
GII78_RS18275	COG4640	response to antibiotic
GII78_RS18280	COG0456	acetyltransferase
GII78_RS18285	COG0148	phosphopyruvate hydratase activity
GII78_RS18290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GII78_RS18295	COG0149	triose-phosphate isomerase activity
GII78_RS18300	COG0126	phosphoglycerate kinase activity
GII78_RS18305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII78_RS18310	COG2390	Transcriptional regulator
GII78_RS18315	COG2814	Major facilitator Superfamily
GII78_RS18320	COG1609	Transcriptional regulator
GII78_RS18325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS18335	COG0583	DNA-binding transcription factor activity
GII78_RS18340	COG0697	spore germination
GII78_RS18345	COG1113	amino acid transport
GII78_RS18350	COG3858	chitin binding
GII78_RS18355	COG1556	Lactate utilization protein
GII78_RS18360	COG1139	Iron-sulfur cluster binding protein
GII78_RS18365	COG0247	lactate metabolic process
GII78_RS18370	COG2197	response regulator
GII78_RS18375	COG4585	Histidine kinase
GII78_RS18380	COG0842	Transport permease protein
GII78_RS18385	COG1131	(ABC) transporter
GII78_RS18390	COG0596	Alpha beta hydrolase
GII78_RS18395	COG2208	phosphoserine phosphatase activity
GII78_RS18400	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GII78_RS18405	COG1874	Beta-galactosidase
GII78_RS18410	COG3833	ABC-type maltose transport systems, permease component
GII78_RS18415	COG1175	transmembrane transport
GII78_RS18420	COG2182	Extracellular solute-binding protein
GII78_RS18425	COG1609	Transcriptional regulator
GII78_RS18430	COG2186	Transcriptional regulator
GII78_RS18435	COG1620	l-lactate permease
GII78_RS18440	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GII78_RS18450	COG5039	Polysaccharide pyruvyl transferase
GII78_RS18455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII78_RS18460	COG0110	maltose O-acetyltransferase activity
GII78_RS18465	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GII78_RS18470	COG2244	polysaccharide biosynthetic process
GII78_RS18475	COG1216	Glycosyl transferase, family 2
GII78_RS18480	COG5039	Polysaccharide pyruvyl transferase
GII78_RS18485	COG1216	Glycosyl transferase, family 2
GII78_RS18495	COG0438	transferase activity, transferring glycosyl groups
GII78_RS18500	COG1215	transferase activity, transferring glycosyl groups
GII78_RS18505	COG0438	transferase activity, transferring glycosyl groups
GII78_RS18510	COG1086	Polysaccharide biosynthesis protein
GII78_RS18515	COG0489	protein tyrosine kinase activity
GII78_RS18520	COG3944	biosynthesis protein
GII78_RS18525	COG1396	sequence-specific DNA binding
GII78_RS18530	COG2272	Belongs to the type-B carboxylesterase lipase family
GII78_RS18540	COG3479	Phenolic acid decarboxylase
GII78_RS18550	COG1794	racemase activity, acting on amino acids and derivatives
GII78_RS18555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII78_RS18560	COG1621	beta-fructofuranosidase activity
GII78_RS18565	COG1621	beta-fructofuranosidase activity
GII78_RS18570	COG0531	amino acid
GII78_RS18575	COG1309	transcriptional regulator
GII78_RS18580	COG2076	Multidrug Resistance protein
GII78_RS18585	COG2076	Multidrug Resistance protein
GII78_RS18595	COG0277	FAD linked oxidase domain protein
GII78_RS18600	COG3621	Patatin-like phospholipase
GII78_RS18610	COG0740	serine-type endopeptidase activity
GII78_RS18615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII78_RS18620	COG0366	Alpha amylase catalytic
GII78_RS18625	COG1554	hydrolase, family 65, central catalytic
GII78_RS18630	COG5521	maltodextrose utilization protein MalA
GII78_RS18635	COG3833	ABC-type maltose transport systems, permease component
GII78_RS18640	COG1175	transmembrane transport
GII78_RS18645	COG2182	Extracellular solute-binding protein
GII78_RS18655	COG1609	Transcriptional regulator
GII78_RS18660	COG1611	Belongs to the LOG family
GII78_RS18665	COG1694	Mazg nucleotide pyrophosphohydrolase
GII78_RS18670	COG0659	secondary active sulfate transmembrane transporter activity
GII78_RS18675	COG0288	reversible hydration of carbon dioxide
GII78_RS18680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII78_RS18685	COG0577	efflux transmembrane transporter activity
GII78_RS18690	COG1136	(ABC) transporter
GII78_RS18695	COG5002	protein histidine kinase activity
GII78_RS18700	COG0745	RESPONSE REGULATOR receiver
GII78_RS18710	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GII78_RS18715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS18720	COG1481	regulation of sporulation
GII78_RS18725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GII78_RS18730	COG1660	Displays ATPase and GTPase activities
GII78_RS18735	COG1051	belongs to the nudix hydrolase family
GII78_RS18740	COG0492	ferredoxin-NADP+ reductase activity
GII78_RS18745	COG0791	NLP P60 protein
GII78_RS18745	COG3883	PFAM NLP P60 protein
GII78_RS18750	COG0457	Tetratricopeptide repeat
GII78_RS18755	COG1132	(ABC) transporter
GII78_RS18775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GII78_RS18775	COG0140	phosphoribosyl-ATP diphosphatase activity
GII78_RS18780	COG0107	imidazoleglycerol-phosphate synthase activity
GII78_RS18785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GII78_RS18790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GII78_RS18795	COG0131	Imidazoleglycerol-phosphate dehydratase
GII78_RS18800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GII78_RS18805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GII78_RS18810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GII78_RS18815	COG4990	cell redox homeostasis
GII78_RS18820	COG5297	Belongs to the glycosyl hydrolase family 6
GII78_RS18825	COG0110	maltose O-acetyltransferase activity
GII78_RS18830	COG0546	phosphoglycolate phosphatase activity
GII78_RS18835	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GII78_RS18840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GII78_RS18845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GII78_RS18850	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GII78_RS18855	COG0363	glucosamine-6-phosphate deaminase activity
GII78_RS18860	COG2188	Transcriptional regulator
GII78_RS18865	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII78_RS18870	COG1846	Transcriptional regulator
GII78_RS18875	COG2124	cytochrome p450
GII78_RS18885	COG1846	Transcriptional regulator
GII78_RS18890	COG2814	Major facilitator Superfamily
GII78_RS18895	COG1950	PFAM Membrane protein of
GII78_RS18900	COG1983	PspC domain protein
GII78_RS18905	COG3595	metallopeptidase activity
GII78_RS18920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII78_RS18925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GII78_RS18930	COG0556	nucleotide-excision repair
GII78_RS18935	COG4897	Protein conserved in bacteria
GII78_RS18940	COG0574	Belongs to the PEP-utilizing enzyme family
GII78_RS18940	COG3848	Pyruvate phosphate dikinase
GII78_RS18945	COG1309	transcriptional regulator
GII78_RS18950	COG2814	Major facilitator Superfamily
GII78_RS18955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII78_RS18965	COG0793	Belongs to the peptidase S41A family
GII78_RS18965	COG3409	Peptidoglycan-binding domain 1 protein
GII78_RS18970	COG2177	Part of the ABC transporter FtsEX involved in
GII78_RS18975	COG2884	Cell division ATP-binding protein ftsE
GII78_RS18980	COG2010	Cytochrome c
GII78_RS18985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS18995	COG0653	protein targeting
GII78_RS19000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GII78_RS19015	COG1516	flagellar protein fliS
GII78_RS19020	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GII78_RS19025	COG1334	flagellar protein FlaG
GII78_RS19030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII78_RS19035	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GII78_RS19040	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GII78_RS19050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII78_RS19055	COG4786	Flagellar basal body rod
GII78_RS19055	COG1256	bacterial-type flagellum assembly
GII78_RS19060	COG3418	PFAM FlgN family protein
GII78_RS19065	COG2747	anti-sigma28 factor FlgM
GII78_RS19075	COG1040	competence protein
GII78_RS19085	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GII78_RS19090	COG1307	EDD domain protein, DegV family
GII78_RS19095	COG2197	response regulator
GII78_RS19100	COG4585	Histidine kinase
GII78_RS19105	COG1739	Uncharacterized protein family UPF0029
GII78_RS19110	COG1316	TRANSCRIPTIONal
GII78_RS19115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII78_RS19120	COG0438	transferase activity, transferring glycosyl groups
GII78_RS19125	COG1215	transferase activity, transferring glycosyl groups
GII78_RS19130	COG3206	protein involved in exopolysaccharide biosynthesis
GII78_RS19135	COG3307	-O-antigen
GII78_RS19140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII78_RS19145	COG0438	transferase activity, transferring glycosyl groups
GII78_RS19145	COG0297	glycogen (starch) synthase activity
GII78_RS19150	COG2244	polysaccharide biosynthetic process
GII78_RS19165	COG2247	cell wall binding repeat
GII78_RS19165	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII78_RS19170	COG2247	cell wall binding repeat
GII78_RS19170	COG2385	sporulation resulting in formation of a cellular spore
GII78_RS19180	COG1316	TRANSCRIPTIONal
GII78_RS19185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GII78_RS19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII78_RS19210	COG1134	teichoic acid transport
GII78_RS19215	COG1682	transport, permease protein
GII78_RS19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII78_RS19230	COG1215	transferase activity, transferring glycosyl groups
GII78_RS19235	COG0463	Glycosyl transferase, family 2
GII78_RS19280	COG4193	domain, Protein
GII78_RS19285	COG1482	cell wall glycoprotein biosynthetic process
GII78_RS19290	COG0697	spore germination
GII78_RS19295	COG0814	amino acid
GII78_RS19305	COG2814	Major facilitator Superfamily
GII78_RS19310	COG1316	TRANSCRIPTIONal
GII78_RS19315	COG0561	phosphatase activity
GII78_RS19320	COG0791	NLP P60 protein
GII78_RS19330	COG2843	Capsule synthesis protein
GII78_RS19340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII78_RS19345	COG1609	Transcriptional regulator
GII78_RS19350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII78_RS19355	COG1869	D-ribose catabolic process
GII78_RS19360	COG1129	ABC transporter
GII78_RS19365	COG1172	Belongs to the binding-protein-dependent transport system permease family
GII78_RS19370	COG1879	ABC-type sugar transport system periplasmic component
GII78_RS19375	COG3103	Sh3 type 3 domain protein
GII78_RS19385	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII78_RS19390	COG3527	Alpha-acetolactate decarboxylase
GII78_RS19395	COG0028	Belongs to the TPP enzyme family
GII78_RS19400	COG0583	DNA-binding transcription factor activity
GII78_RS19405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GII78_RS19420	COG5337	Spore coat protein CotH
GII78_RS19430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GII78_RS19440	COG0405	Gamma-glutamyltransferase
GII78_RS19445	COG1522	sequence-specific DNA binding
GII78_RS19450	COG2059	Chromate
GII78_RS19455	COG2059	Chromate
GII78_RS19465	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII78_RS19470	COG0583	DNA-binding transcription factor activity
GII78_RS19520	COG3878	Protein conserved in bacteria
GII78_RS19525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII78_RS19530	COG4464	protein tyrosine phosphatase activity
GII78_RS19535	COG0489	protein tyrosine kinase activity
GII78_RS19540	COG3944	biosynthesis protein
GII78_RS19550	COG4715	Zinc finger, swim domain protein
GII78_RS19555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII78_RS19560	COG0561	phosphatase activity
GII78_RS19565	COG1349	DNA-binding transcription factor activity
GII78_RS19570	COG0629	single-stranded DNA binding
GII78_RS19585	COG3764	Sortase (surface protein transpeptidase)
GII78_RS19600	COG1970	mechanosensitive ion channel activity
GII78_RS19605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII78_RS19610	COG0457	Tetratricopeptide repeat
GII78_RS19615	COG4786	Flagellar basal body rod
GII78_RS19620	COG4786	Flagellar basal body rod
GII78_RS19625	COG1077	Cell shape determining protein MreB Mrl
GII78_RS19630	COG1609	Transcriptional regulator
GII78_RS19640	COG1846	Transcriptional regulator
GII78_RS19645	COG2814	Major facilitator Superfamily
GII78_RS19650	COG3420	alginic acid biosynthetic process
GII78_RS19655	COG1953	Uracil, thiamine, allantoin
GII78_RS19660	COG0477	Major facilitator Superfamily
GII78_RS19665	COG1335	isochorismatase
GII78_RS19675	COG0004	ammonium transporteR
GII78_RS19680	COG0347	Belongs to the P(II) protein family
GII78_RS19685	COG0671	phosphoesterase, PA-phosphatase related
GII78_RS19695	COG0739	heme binding
GII78_RS19700	COG1247	-acetyltransferase
GII78_RS19720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII78_RS19725	COG0789	Transcriptional regulator
GII78_RS19735	COG2910	NAD(P)H-binding
GII78_RS19740	COG1959	2 iron, 2 sulfur cluster binding
GII78_RS19745	COG0804	urea catabolic process
GII78_RS19750	COG0832	Belongs to the urease beta subunit family
GII78_RS19755	COG0831	urea catabolic process
GII78_RS19770	COG3237	CsbD-like
GII78_RS19775	COG1994	Peptidase M50
GII78_RS19780	COG0457	Tetratricopeptide repeat
GII78_RS19785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GII78_RS19790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GII78_RS19800	COG2304	oxidoreductase activity
GII78_RS19810	COG2304	oxidoreductase activity
GII78_RS19815	COG2385	sporulation resulting in formation of a cellular spore
GII78_RS19820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII78_RS19830	COG4836	Membrane
GII78_RS19840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GII78_RS19845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GII78_RS19850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GII78_RS19855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GII78_RS19860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GII78_RS19865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GII78_RS19875	COG0356	it plays a direct role in the translocation of protons across the membrane
GII78_RS19885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GII78_RS19890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GII78_RS19895	COG4475	Protein of unknown function (DUF436)
GII78_RS19900	COG0698	ribose 5-phosphate isomerase
GII78_RS19905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII78_RS19910	COG1971	Probably functions as a manganese efflux pump
GII78_RS19915	COG0009	L-threonylcarbamoyladenylate synthase
GII78_RS19920	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GII78_RS19940	COG2890	protein-(glutamine-N5) methyltransferase activity
GII78_RS19945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GII78_RS19950	COG0346	lactoylglutathione lyase activity
GII78_RS19955	COG0789	Transcriptional regulator
GII78_RS19960	COG0679	Auxin Efflux Carrier
GII78_RS19965	COG0281	malic enzyme
GII78_RS19970	COG1435	thymidine kinase activity
GII78_RS19980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GII78_RS19990	COG1494	fructose-1,6-bisphosphatase
GII78_RS19995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII78_RS20000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GII78_RS20005	COG0191	fructose-bisphosphate aldolase activity
GII78_RS20010	COG2204	response regulator
GII78_RS20015	COG4821	SIS domain
GII78_RS20020	COG0504	CTP synthase activity
GII78_RS20025	COG3343	RNA polymerase activity
GII78_RS20030	COG1960	acyl-CoA dehydrogenase activity
GII78_RS20035	COG0247	lactate metabolic process
GII78_RS20035	COG2181	nitrate reductase activity
GII78_RS20040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII78_RS20045	COG4294	response to UV
GII78_RS20055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII78_RS20060	COG1132	(ABC) transporter
GII78_RS20065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII78_RS20075	COG2181	nitrate reductase activity
GII78_RS20080	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GII78_RS20085	COG1140	nitrate reductase beta subunit
GII78_RS20090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GII78_RS20095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII78_RS20105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII78_RS20110	COG2223	nitrite transmembrane transporter activity
GII78_RS20115	COG0018	arginyl-trna synthetase
GII78_RS20120	COG4506	Protein conserved in bacteria
GII78_RS20135	COG0535	radical SAM domain protein
GII78_RS20145	COG1131	(ABC) transporter
GII78_RS20150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GII78_RS20155	COG0612	Peptidase, M16
GII78_RS20160	COG0612	Peptidase, M16
GII78_RS20170	COG3391	amine dehydrogenase activity
GII78_RS20175	COG3391	amine dehydrogenase activity
GII78_RS20185	COG0457	Tetratricopeptide repeat
GII78_RS20215	COG1131	(ABC) transporter
GII78_RS20225	COG0010	Belongs to the arginase family
GII78_RS20230	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GII78_RS20235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII78_RS20245	COG1994	Peptidase M50
GII78_RS20250	COG1942	4-Oxalocrotonate Tautomerase
GII78_RS20255	COG1846	Transcriptional regulator
GII78_RS20260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII78_RS20275	COG1959	2 iron, 2 sulfur cluster binding
GII78_RS20280	COG3465	dGTPase activity
GII78_RS20285	COG1078	dGTPase activity
GII78_RS20290	COG4844	belongs to the
GII78_RS20300	COG0697	spore germination
GII78_RS20305	COG0095	Lipoate-protein ligase
GII78_RS20310	COG0583	DNA-binding transcription factor activity
GII78_RS20315	COG0280	phosphate acetyltransferase
GII78_RS20320	COG3253	May function as heme-dependent peroxidase
GII78_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS20330	COG0436	Aminotransferase
GII78_RS20335	COG2814	Major facilitator Superfamily
GII78_RS20340	COG0151	Belongs to the GarS family
GII78_RS20345	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS20350	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS20355	COG0077	Prephenate dehydratase
GII78_RS20360	COG2814	Major facilitator Superfamily
GII78_RS20365	COG0833	amino acid
GII78_RS20370	COG4187	Peptidase family M20/M25/M40
GII78_RS20375	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS20380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII78_RS20390	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GII78_RS20395	COG1091	dTDP-4-dehydrorhamnose reductase activity
GII78_RS20400	COG1088	dTDP-glucose 4,6-dehydratase activity
GII78_RS20405	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GII78_RS20410	COG3980	spore coat polysaccharide biosynthesis protein
GII78_RS20415	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GII78_RS20420	COG2089	acid synthase
GII78_RS20425	COG0456	acetyltransferase
GII78_RS20430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII78_RS20435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII78_RS20440	COG0463	Glycosyl transferase, family 2
GII78_RS20450	COG2363	Small membrane protein
GII78_RS20455	COG2233	PERMEase
GII78_RS20465	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS20470	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GII78_RS20475	COG1216	Glycosyl transferase, family 2
GII78_RS20490	COG1695	Transcriptional regulator
GII78_RS20495	COG0351	phosphomethylpyrimidine kinase
GII78_RS20505	COG1621	beta-fructofuranosidase activity
GII78_RS20510	COG1263	PTS System
GII78_RS20510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS20515	COG2116	formate transmembrane transporter activity
GII78_RS20520	COG3711	transcriptional antiterminator
GII78_RS20530	COG1404	Belongs to the peptidase S8 family
GII78_RS20535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS20540	COG0778	Nitroreductase
GII78_RS20545	COG0772	Belongs to the SEDS family
GII78_RS20555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII78_RS20560	COG1845	cytochrome c oxidase, subunit III
GII78_RS20565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII78_RS20570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII78_RS20575	COG2261	transglycosylase associated protein
GII78_RS20580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GII78_RS20585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GII78_RS20590	COG2246	polysaccharide biosynthetic process
GII78_RS20595	COG1309	transcriptional regulator
GII78_RS20605	COG3162	membrane
GII78_RS20610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII78_RS20615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GII78_RS20620	COG2837	iron assimilation
GII78_RS20625	COG2822	iron ion transport
GII78_RS20630	COG0672	)-iron permease
GII78_RS20635	COG0352	thiamine-phosphate diphosphorylase activity
GII78_RS20640	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GII78_RS20645	COG0583	DNA-binding transcription factor activity
GII78_RS20650	COG1380	Effector of murein hydrolase LrgA
GII78_RS20655	COG1346	cytolysis
GII78_RS20660	COG2814	Major facilitator Superfamily
GII78_RS20665	COG4895	conserved protein (DUF2196)
GII78_RS20670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GII78_RS20675	COG0346	lactoylglutathione lyase activity
GII78_RS20680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII78_RS20685	COG1404	Belongs to the peptidase S8 family
GII78_RS20690	COG1263	PTS System
GII78_RS20690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS20695	COG3711	transcriptional antiterminator
GII78_RS20700	COG1442	glycosyl transferase family 8
GII78_RS20705	COG5522	Integral membrane protein (intg_mem_TP0381)
GII78_RS20710	COG1846	Transcriptional regulator
GII78_RS20715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII78_RS20720	COG2234	aminopeptidase activity
GII78_RS20740	COG2357	RelA SpoT domain protein
GII78_RS20745	COG1575	Belongs to the MenA family. Type 1 subfamily
GII78_RS20760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII78_RS20765	COG1696	Membrane protein involved in D-alanine export
GII78_RS20770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII78_RS20775	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GII78_RS20780	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GII78_RS20785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII78_RS20790	COG1486	melibiose metabolic process
GII78_RS20795	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII78_RS20800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII78_RS20805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII78_RS20810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII78_RS20810	COG3711	transcriptional antiterminator
GII78_RS20820	COG2094	Belongs to the DNA glycosylase MPG family
GII78_RS20825	COG0753	catalase activity
GII78_RS20835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII78_RS20840	COG1131	(ABC) transporter
GII78_RS20860	COG1595	DNA-templated transcription, initiation
GII78_RS20865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GII78_RS20870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GII78_RS20875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GII78_RS20880	COG4988	ABC transporter
GII78_RS20885	COG1294	oxidase, subunit
GII78_RS20890	COG1271	oxidase subunit
GII78_RS20895	COG3493	citrate carrier protein
GII78_RS20900	COG0501	Belongs to the peptidase M48B family
GII78_RS20910	COG0726	polysaccharide deacetylase
GII78_RS20915	COG3842	ATPase activity
GII78_RS20920	COG2508	Transcriptional regulator
GII78_RS20925	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS20930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII78_RS20940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII78_RS20945	COG1881	PFAM PEBP family protein
GII78_RS20950	COG0583	DNA-binding transcription factor activity
GII78_RS20960	COG4585	Histidine kinase
GII78_RS20965	COG2197	response regulator
GII78_RS20970	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII78_RS20980	COG4894	glucomannan catabolic process
GII78_RS20985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII78_RS20990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII78_RS20995	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS21000	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GII78_RS21005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GII78_RS21010	COG2610	gluconate transmembrane transporter activity
GII78_RS21015	COG0500	methyltransferase
GII78_RS21020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII78_RS21035	COG0693	protein deglycase activity
GII78_RS21035	COG0753	catalase activity
GII78_RS21040	COG2851	Citrate transporter
GII78_RS21045	COG2273	Hydrolase Family 16
GII78_RS21050	COG3711	transcriptional antiterminator
GII78_RS21060	COG2270	Major facilitator Superfamily
GII78_RS21065	COG0513	Belongs to the DEAD box helicase family
GII78_RS21070	COG3401	FG-GAP repeat protein
GII78_RS21070	COG2755	lipolytic protein G-D-S-L family
GII78_RS21100	COG0697	spore germination
GII78_RS21105	COG0589	response to stress
GII78_RS21110	COG2723	6-phospho-beta-galactosidase activity
GII78_RS21115	COG2190	(PTS) system
GII78_RS21115	COG1263	PTS System
GII78_RS21115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS21165	COG3507	Belongs to the glycosyl hydrolase 43 family
GII78_RS21180	COG2986	histidine ammonia-lyase
GII78_RS21185	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GII78_RS21190	COG1228	amidohydrolase
GII78_RS21195	COG0010	Belongs to the arginase family
GII78_RS21200	COG0833	amino acid
GII78_RS21205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GII78_RS21210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII78_RS21215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GII78_RS21220	COG2390	Transcriptional regulator
GII78_RS21230	COG3192	ethanolamine utilization protein
GII78_RS21235	COG2079	MmgE PrpD family protein
GII78_RS21240	COG1473	amidohydrolase
GII78_RS21245	COG1126	abc transporter atp-binding protein
GII78_RS21250	COG0765	amino acid transport
GII78_RS21255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII78_RS21260	COG0456	acetyltransferase
GII78_RS21265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII78_RS21275	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GII78_RS21280	COG0561	phosphatase activity
GII78_RS21310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII78_RS21315	COG5294	Protein conserved in bacteria
GII78_RS21320	COG0577	efflux transmembrane transporter activity
GII78_RS21325	COG1136	(ABC) transporter
GII78_RS21330	COG2205	protein histidine kinase activity
GII78_RS21335	COG0745	RESPONSE REGULATOR receiver
GII78_RS21340	COG0191	fructose-bisphosphate aldolase activity
GII78_RS21345	COG1082	Xylose isomerase domain protein TIM barrel
GII78_RS21350	COG1082	Xylose isomerase domain protein TIM barrel
GII78_RS21355	COG0673	inositol 2-dehydrogenase activity
GII78_RS21360	COG2814	Major facilitator Superfamily
GII78_RS21365	COG1082	Xylose isomerase domain protein TIM barrel
GII78_RS21370	COG3962	Belongs to the TPP enzyme family
GII78_RS21375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII78_RS21385	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS21390	COG1349	DNA-binding transcription factor activity
GII78_RS21395	COG0667	Aldo Keto reductase
GII78_RS21410	COG2814	Major facilitator Superfamily
GII78_RS21415	COG0326	Molecular chaperone. Has ATPase activity
GII78_RS21425	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS21430	COG1309	transcriptional regulator
GII78_RS21435	COG1012	belongs to the aldehyde dehydrogenase family
GII78_RS21445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GII78_RS21455	COG1714	RDD family
GII78_RS21460	COG2311	Membrane
GII78_RS21465	COG1917	Cupin 2, conserved barrel domain protein
GII78_RS21470	COG1309	transcriptional regulator
GII78_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
GII78_RS21480	COG1846	Transcriptional regulator
GII78_RS21485	COG1380	Effector of murein hydrolase LrgA
GII78_RS21490	COG1346	cytolysis
GII78_RS21495	COG5039	Polysaccharide pyruvyl transferase
GII78_RS21500	COG1929	Belongs to the glycerate kinase type-1 family
GII78_RS21505	COG1802	Transcriptional regulator
GII78_RS21510	COG1070	Carbohydrate kinase
GII78_RS21515	COG2610	gluconate transmembrane transporter activity
GII78_RS21520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GII78_RS21525	COG0450	alkyl hydroperoxide reductase
GII78_RS21530	COG3634	alkyl hydroperoxide reductase activity
GII78_RS21540	COG2723	6-phospho-beta-galactosidase activity
GII78_RS21545	COG2190	(PTS) system
GII78_RS21550	COG1263	PTS System
GII78_RS21550	COG2190	(PTS) system
GII78_RS21550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII78_RS21555	COG2188	Transcriptional regulator
GII78_RS21565	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GII78_RS21600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GII78_RS21615	COG1063	alcohol dehydrogenase
GII78_RS21635	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GII78_RS21640	COG0456	acetyltransferase
GII78_RS21645	COG0457	Tetratricopeptide repeat
GII78_RS21655	COG0010	Belongs to the arginase family
GII78_RS21660	COG0833	amino acid
GII78_RS21665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII78_RS21670	COG3829	transcription factor binding
GII78_RS21675	COG5002	protein histidine kinase activity
GII78_RS21680	COG0745	RESPONSE REGULATOR receiver
GII78_RS21700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII78_RS21705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GII78_RS21710	COG4853	Protein conserved in bacteria
GII78_RS21715	COG4863	YycH protein
GII78_RS21720	COG5002	protein histidine kinase activity
GII78_RS21725	COG0745	RESPONSE REGULATOR receiver
GII78_RS21755	COG0346	lactoylglutathione lyase activity
GII78_RS21760	COG0305	Participates in initiation and elongation during chromosome replication
GII78_RS21775	COG3093	addiction module antidote protein HigA
GII78_RS21780	COG2807	transmembrane transport
GII78_RS21785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII78_RS21790	COG0359	binds to the 23S rRNA
GII78_RS21795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GII78_RS21800	COG4241	membrane
GII78_RS21810	COG5577	PFAM Coat F domain
GII78_RS21815	COG1733	regulation of RNA biosynthetic process
GII78_RS21820	COG1227	inorganic diphosphatase activity
GII78_RS21830	COG2271	Major facilitator Superfamily
GII78_RS21835	COG4978	Transcriptional regulator
GII78_RS21835	COG0789	Transcriptional regulator
GII78_RS21845	COG4319	ketosteroid isomerase
GII78_RS21850	COG1357	PFAM Pentapeptide repeats (8 copies)
GII78_RS21855	COG2814	Major facilitator Superfamily
GII78_RS21860	COG0583	DNA-binding transcription factor activity
GII78_RS21865	COG2153	protein acetylation
GII78_RS21875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII78_RS21880	COG1846	Transcriptional regulator
GII78_RS21885	COG2153	protein acetylation
GII78_RS21890	COG2364	Membrane
GII78_RS21895	COG0456	acetyltransferase
GII78_RS21900	COG2315	Protein conserved in bacteria
GII78_RS21905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII78_RS21915	COG2814	Major facilitator Superfamily
GII78_RS21925	COG1331	Highly conserved protein containing a thioredoxin domain
GII78_RS21930	COG1266	CAAX protease self-immunity
GII78_RS21935	COG0477	Major facilitator Superfamily
GII78_RS21935	COG2814	Major facilitator Superfamily
GII78_RS21940	COG0110	maltose O-acetyltransferase activity
GII78_RS21945	COG0346	lactoylglutathione lyase activity
GII78_RS21950	COG1609	Transcriptional regulator
GII78_RS21955	COG0708	Exodeoxyribonuclease III
GII78_RS21960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GII78_RS21965	COG0629	single-stranded DNA binding
GII78_RS21970	COG0360	Binds together with S18 to 16S ribosomal RNA
GII78_RS21975	COG0012	GTP binding
GII78_RS21980	COG0243	molybdopterin cofactor binding
GII78_RS21985	COG4481	Protein conserved in bacteria
GII78_RS21990	COG3949	Membrane
GII78_RS22000	COG1475	DNA binding
GII78_RS22005	COG1192	Involved in chromosome partitioning
GII78_RS22015	COG1475	DNA binding
GII78_RS22020	COG0357	Ribosomal RNA small subunit methyltransferase G
GII78_RS22025	COG0445	tRNA wobble uridine modification
GII78_RS22030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GII78_RS22035	COG1847	R3H domain protein
GII78_RS22040	COG0706	membrane insertase activity
GII78_RS22045	COG0594	ribonuclease P activity