locus-tag	class	description
C2H93_RS00005	COG0039	L-malate dehydrogenase activity
C2H93_RS00010	COG1620	l-lactate permease
C2H93_RS00015	COG2814	Major facilitator Superfamily
C2H93_RS00020	COG1846	Transcriptional regulator
C2H93_RS00025	COG1280	lysine exporter protein (LysE YggA)
C2H93_RS00030	COG3403	YqcI/YcgG family
C2H93_RS00035	COG1113	amino acid transport
C2H93_RS00040	COG3665	Urea carboxylase-associated protein
C2H93_RS00045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2H93_RS00050	COG1660	Displays ATPase and GTPase activities
C2H93_RS00055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H93_RS00060	COG2226	methyltransferase
C2H93_RS00065	COG0583	DNA-binding transcription factor activity
C2H93_RS00070	COG3458	cephalosporin-C deacetylase activity
C2H93_RS00075	COG3541	Predicted nucleotidyltransferase
C2H93_RS00080	COG0506	proline dehydrogenase activity
C2H93_RS00085	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS00090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H93_RS00095	COG2508	Transcriptional regulator
C2H93_RS00100	COG3689	TIGRFAM TIGR03943 family protein
C2H93_RS00105	COG0701	Predicted permease
C2H93_RS00110	COG2267	carboxylic ester hydrolase activity
C2H93_RS00115	COG0492	ferredoxin-NADP+ reductase activity
C2H93_RS00120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H93_RS00120	COG1587	Uroporphyrinogen-III synthase
C2H93_RS00125	COG2146	nitrite reductase [NAD(P)H] activity
C2H93_RS00130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H93_RS00135	COG0243	molybdopterin cofactor binding
C2H93_RS00140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H93_RS00145	COG2223	nitrite transmembrane transporter activity
C2H93_RS00150	COG1469	GTP cyclohydrolase I activity
C2H93_RS00155	COG1376	ErfK ybiS ycfS ynhG family protein
C2H93_RS00165	COG0523	cobalamin synthesis protein
C2H93_RS00170	COG0765	amino acid transport
C2H93_RS00175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H93_RS00185	COG1714	RDD family
C2H93_RS00195	COG1846	Transcriptional regulator
C2H93_RS00205	COG3842	ATPase activity
C2H93_RS00210	COG2723	6-phospho-beta-galactosidase activity
C2H93_RS00220	COG3209	COG3209 Rhs family protein
C2H93_RS00225	COG0840	transmembrane signaling receptor activity
C2H93_RS00225	COG3290	protein histidine kinase activity
C2H93_RS00230	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H93_RS00235	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H93_RS00240	COG1733	regulation of RNA biosynthetic process
C2H93_RS00245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS00265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS00270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS00275	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2H93_RS00280	COG2814	Major facilitator Superfamily
C2H93_RS00290	COG0697	spore germination
C2H93_RS00295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS00305	COG2364	Membrane
C2H93_RS00310	COG1126	abc transporter atp-binding protein
C2H93_RS00315	COG0765	amino acid transport
C2H93_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H93_RS00325	COG0583	DNA-binding transcription factor activity
C2H93_RS00330	COG0163	prenyltransferase activity
C2H93_RS00335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H93_RS00350	COG0596	Alpha beta hydrolase
C2H93_RS00355	COG3104	oligopeptide transport
C2H93_RS00360	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H93_RS00370	COG0697	spore germination
C2H93_RS00380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H93_RS00385	COG1136	(ABC) transporter
C2H93_RS00390	COG0577	efflux transmembrane transporter activity
C2H93_RS00395	COG0745	RESPONSE REGULATOR receiver
C2H93_RS00400	COG5002	protein histidine kinase activity
C2H93_RS00400	COG3850	Histidine kinase
C2H93_RS00405	COG0457	Tetratricopeptide repeat
C2H93_RS00425	COG0527	aspartate kinase activity
C2H93_RS00430	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS00435	COG4605	iron ion homeostasis
C2H93_RS00440	COG4604	ABC transporter, ATP-binding protein
C2H93_RS00445	COG4607	ABC-type enterochelin transport system periplasmic component
C2H93_RS00450	COG2814	Major facilitator Superfamily
C2H93_RS00455	COG1309	transcriptional regulator
C2H93_RS00460	COG0778	Nitroreductase
C2H93_RS00465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H93_RS00470	COG0640	Transcriptional regulator
C2H93_RS00475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS00480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H93_RS00485	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS00510	COG4975	Glucose uptake
C2H93_RS00515	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS00520	COG4549	nuclear export factor GLE1
C2H93_RS00525	COG1276	copper resistance
C2H93_RS00525	COG2372	response to copper ion
C2H93_RS00530	COG1349	DNA-binding transcription factor activity
C2H93_RS00540	COG2213	PTS system mannitol-specific
C2H93_RS00545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS00550	COG0246	Mannitol dehydrogenase
C2H93_RS00555	COG0473	3-isopropylmalate dehydrogenase activity
C2H93_RS00560	COG0681	Belongs to the peptidase S26 family
C2H93_RS00565	COG0412	Dienelactone hydrolase
C2H93_RS00570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H93_RS00580	COG0561	phosphatase activity
C2H93_RS00585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H93_RS00590	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H93_RS00595	COG4336	lyase activity
C2H93_RS00600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H93_RS00605	COG1984	allophanate hydrolase subunit 2
C2H93_RS00610	COG1414	Transcriptional regulator
C2H93_RS00615	COG2755	lipolytic protein G-D-S-L family
C2H93_RS00630	COG0768	penicillin binding
C2H93_RS00635	COG4989	oxidoreductase activity
C2H93_RS00640	COG3711	transcriptional antiterminator
C2H93_RS00645	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS00650	COG2226	methyltransferase
C2H93_RS00655	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS00660	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS00665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS00670	COG3871	stress protein (general stress protein 26)
C2H93_RS00680	COG2814	Major facilitator Superfamily
C2H93_RS00685	COG1522	sequence-specific DNA binding
C2H93_RS00690	COG0551	DNA topoisomerase type I activity
C2H93_RS00690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H93_RS00695	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H93_RS00700	COG3706	GGDEF domain
C2H93_RS00705	COG5298	Protein conserved in bacteria
C2H93_RS00710	COG1215	transferase activity, transferring glycosyl groups
C2H93_RS00720	COG0531	amino acid
C2H93_RS00730	COG0028	Belongs to the TPP enzyme family
C2H93_RS00745	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H93_RS00750	COG2261	transglycosylase associated protein
C2H93_RS00755	COG4876	unkown
C2H93_RS00760	COG2217	Heavy metal translocating P-type atpase
C2H93_RS00765	COG3729	General stress protein
C2H93_RS00770	COG0662	Cupin 2, conserved barrel domain protein
C2H93_RS00775	COG2329	Antibiotic biosynthesis monooxygenase
C2H93_RS00780	COG3546	catalase activity
C2H93_RS00785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H93_RS00790	COG3290	protein histidine kinase activity
C2H93_RS00795	COG4565	transcriptional regulatory protein
C2H93_RS00800	COG1301	dicarboxylic acid transport
C2H93_RS00805	COG0628	permease
C2H93_RS00810	COG1131	(ABC) transporter
C2H93_RS00815	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H93_RS00825	COG1960	acyl-CoA dehydrogenase activity
C2H93_RS00840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H93_RS00845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS00850	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H93_RS00855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H93_RS00860	COG0513	Belongs to the DEAD box helicase family
C2H93_RS00865	COG3402	PFAM membrane-flanked domain
C2H93_RS00870	COG3428	Bacterial PH domain
C2H93_RS00875	COG0705	Rhomboid family
C2H93_RS00880	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H93_RS00885	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H93_RS00890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H93_RS00895	COG0864	Transcriptional regulator
C2H93_RS00900	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H93_RS00905	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS00910	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS00915	COG2172	sigma factor antagonist activity
C2H93_RS00920	COG2208	phosphoserine phosphatase activity
C2H93_RS00925	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS00930	COG2172	sigma factor antagonist activity
C2H93_RS00935	COG1191	sigma factor activity
C2H93_RS00940	COG2208	phosphoserine phosphatase activity
C2H93_RS00960	COG1673	EVE domain
C2H93_RS00965	COG1846	Transcriptional regulator
C2H93_RS00970	COG2183	response to ionizing radiation
C2H93_RS00980	COG3091	SprT-like family
C2H93_RS01020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS01025	COG1522	sequence-specific DNA binding
C2H93_RS01030	COG1522	sequence-specific DNA binding
C2H93_RS01035	COG1335	isochorismatase
C2H93_RS01040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H93_RS01045	COG2814	Major facilitator Superfamily
C2H93_RS01060	COG3239	Fatty acid desaturase
C2H93_RS01065	COG1278	Cold shock
C2H93_RS01070	COG1329	Transcriptional regulator
C2H93_RS01080	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS01080	COG2207	Transcriptional regulator
C2H93_RS01085	COG0697	spore germination
C2H93_RS01090	COG2207	Transcriptional regulator
C2H93_RS01090	COG3708	Transcriptional regulator
C2H93_RS01095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS01100	COG0477	Major facilitator Superfamily
C2H93_RS01110	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H93_RS01120	COG0697	spore germination
C2H93_RS01125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS01130	COG2030	dehydratase
C2H93_RS01135	COG3545	Serine hydrolase
C2H93_RS01140	COG1733	regulation of RNA biosynthetic process
C2H93_RS01145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS01150	COG0640	Transcriptional regulator
C2H93_RS01155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H93_RS01165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS01170	COG1316	TRANSCRIPTIONal
C2H93_RS01185	COG5002	protein histidine kinase activity
C2H93_RS01190	COG0745	RESPONSE REGULATOR receiver
C2H93_RS01195	COG0697	spore germination
C2H93_RS01200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS01205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H93_RS01210	COG0640	Transcriptional regulator
C2H93_RS01215	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H93_RS01230	COG4585	Histidine kinase
C2H93_RS01235	COG2197	response regulator
C2H93_RS01240	COG2409	Drug exporters of the RND superfamily
C2H93_RS01245	COG1811	Na channel or pump
C2H93_RS01250	COG0789	Transcriptional regulator
C2H93_RS01250	COG4978	Transcriptional regulator
C2H93_RS01255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H93_RS01260	COG0778	Nitroreductase
C2H93_RS01265	COG0346	lactoylglutathione lyase activity
C2H93_RS01270	COG2259	Doxx family
C2H93_RS01275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS01295	COG2323	membrane
C2H93_RS01300	COG2323	membrane
C2H93_RS01305	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H93_RS01320	COG1309	transcriptional regulator
C2H93_RS01330	COG0456	acetyltransferase
C2H93_RS01335	COG0488	(ABC) transporter
C2H93_RS01340	COG1113	amino acid transport
C2H93_RS01345	COG2318	DinB family
C2H93_RS01350	COG1846	Transcriptional regulator
C2H93_RS01355	COG1033	growth of symbiont in host cell
C2H93_RS01355	COG2409	Drug exporters of the RND superfamily
C2H93_RS01360	COG0778	Nitroreductase
C2H93_RS01365	COG1846	Transcriptional regulator
C2H93_RS01370	COG2814	Major facilitator Superfamily
C2H93_RS01375	COG0730	response to heat
C2H93_RS01380	COG1802	Transcriptional regulator
C2H93_RS01385	COG1388	LysM domain
C2H93_RS01385	COG3858	chitin binding
C2H93_RS01390	COG1819	glycosyl
C2H93_RS01400	COG1785	Belongs to the alkaline phosphatase family
C2H93_RS01405	COG5646	InterPro IPR014922
C2H93_RS01415	COG0454	-acetyltransferase
C2H93_RS01420	COG1078	dGTPase activity
C2H93_RS01430	COG2814	Major facilitator Superfamily
C2H93_RS01435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H93_RS01440	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H93_RS01445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H93_RS01450	COG2723	6-phospho-beta-galactosidase activity
C2H93_RS01455	COG2188	Transcriptional regulator
C2H93_RS01460	COG1940	carbohydrate kinase activity
C2H93_RS01465	COG1482	cell wall glycoprotein biosynthetic process
C2H93_RS01470	COG4124	Belongs to the glycosyl hydrolase 26 family
C2H93_RS01515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H93_RS01520	COG0802	atpase or kinase
C2H93_RS01525	COG1214	PFAM Peptidase M22, glycoprotease
C2H93_RS01530	COG0456	acetyltransferase
C2H93_RS01535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2H93_RS01540	COG0488	(ABC) transporter
C2H93_RS01545	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H93_RS01550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H93_RS01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H93_RS01560	COG0805	protein transport
C2H93_RS01570	COG1266	CAAX protease self-immunity
C2H93_RS01580	COG0459	protein refolding
C2H93_RS01585	COG4974	Belongs to the 'phage' integrase family
C2H93_RS01610	COG1073	alpha beta
C2H93_RS01615	COG0457	Tetratricopeptide repeat
C2H93_RS01620	COG1063	alcohol dehydrogenase
C2H93_RS01625	COG2211	Major facilitator Superfamily
C2H93_RS01630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H93_RS01635	COG1842	Phage shock protein A
C2H93_RS01640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H93_RS01645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H93_RS01650	COG4260	virion core protein, lumpy skin disease virus
C2H93_RS01660	COG2814	Major facilitator Superfamily
C2H93_RS01665	COG1063	alcohol dehydrogenase
C2H93_RS01670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H93_RS01675	COG0823	Involved in the tonB-independent uptake of proteins
C2H93_RS01690	COG2267	carboxylic ester hydrolase activity
C2H93_RS01700	COG2132	Multicopper oxidase
C2H93_RS01705	COG1113	amino acid transport
C2H93_RS01715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H93_RS01720	COG0714	Associated with various cellular activities
C2H93_RS01725	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H93_RS01730	COG1305	Transglutaminase-like
C2H93_RS01735	COG0519	Catalyzes the synthesis of GMP from XMP
C2H93_RS01735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H93_RS01750	COG2252	PERMEase
C2H93_RS01755	COG3064	Membrane
C2H93_RS01765	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H93_RS01775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H93_RS01780	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H93_RS01785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H93_RS01790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H93_RS01795	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H93_RS01800	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H93_RS01805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H93_RS01810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H93_RS01815	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H93_RS01820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H93_RS01825	COG0138	bifunctional purine biosynthesis protein purh
C2H93_RS01830	COG0151	Belongs to the GarS family
C2H93_RS01835	COG1522	sequence-specific DNA binding
C2H93_RS01840	COG0531	amino acid
C2H93_RS01850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H93_RS01855	COG1470	cell adhesion involved in biofilm formation
C2H93_RS01860	COG4496	protein, YerC YecD
C2H93_RS01865	COG0069	glutamate synthase activity
C2H93_RS01870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H93_RS01875	COG0210	DNA helicase
C2H93_RS01880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H93_RS01885	COG4851	CamS sex pheromone cAM373 precursor
C2H93_RS01890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H93_RS01895	COG1285	pathogenesis
C2H93_RS01900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H93_RS01905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H93_RS01910	COG0154	amidase activity
C2H93_RS01915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H93_RS01925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H93_RS01930	COG1597	lipid kinase activity
C2H93_RS01935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H93_RS01950	COG0367	asparagine synthase
C2H93_RS01985	COG1136	(ABC) transporter
C2H93_RS02000	COG0457	Tetratricopeptide repeat
C2H93_RS02010	COG0217	transcriptional regulatory protein
C2H93_RS02020	COG1309	transcriptional regulator
C2H93_RS02025	COG3631	Ketosteroid isomerase-related protein
C2H93_RS02045	COG3546	catalase activity
C2H93_RS02050	COG0454	-acetyltransferase
C2H93_RS02060	COG5578	integral membrane protein
C2H93_RS02065	COG2972	Histidine kinase
C2H93_RS02070	COG2207	Transcriptional regulator
C2H93_RS02070	COG4753	response regulator
C2H93_RS02075	COG1653	transport
C2H93_RS02080	COG1175	transmembrane transport
C2H93_RS02085	COG0395	ABC-type sugar transport system, permease component
C2H93_RS02090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H93_RS02095	COG2207	Transcriptional regulator
C2H93_RS02100	COG2755	lipolytic protein G-D-S-L family
C2H93_RS02110	COG5578	integral membrane protein
C2H93_RS02115	COG3401	FG-GAP repeat protein
C2H93_RS02120	COG3401	FG-GAP repeat protein
C2H93_RS02125	COG2755	lipolytic protein G-D-S-L family
C2H93_RS02130	COG1874	Beta-galactosidase
C2H93_RS02140	COG1653	transport
C2H93_RS02145	COG4209	transmembrane transport
C2H93_RS02150	COG0395	ABC-type sugar transport system, permease component
C2H93_RS02155	COG1486	melibiose metabolic process
C2H93_RS02160	COG2323	membrane
C2H93_RS02165	COG2329	Antibiotic biosynthesis monooxygenase
C2H93_RS02170	COG0346	lactoylglutathione lyase activity
C2H93_RS02185	COG5583	Uncharacterized small protein (DUF2292)
C2H93_RS02190	COG0670	Belongs to the BI1 family
C2H93_RS02200	COG1846	Transcriptional regulator
C2H93_RS02205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H93_RS02215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H93_RS02215	COG2124	cytochrome p450
C2H93_RS02220	COG1368	sulfuric ester hydrolase activity
C2H93_RS02225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H93_RS02230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H93_RS02235	COG1442	glycosyl transferase family 8
C2H93_RS02240	COG1216	Glycosyl transferase, family 2
C2H93_RS02245	COG1442	glycosyl transferase family 8
C2H93_RS02250	COG2223	nitrite transmembrane transporter activity
C2H93_RS02255	COG1011	Hydrolase
C2H93_RS02260	COG0531	amino acid
C2H93_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS02270	COG0840	transmembrane signaling receptor activity
C2H93_RS02275	COG0488	(ABC) transporter
C2H93_RS02285	COG0789	Transcriptional regulator
C2H93_RS02290	COG2814	Major facilitator Superfamily
C2H93_RS02295	COG1404	Belongs to the peptidase S8 family
C2H93_RS02315	COG0488	(ABC) transporter
C2H93_RS02320	COG0513	Belongs to the DEAD box helicase family
C2H93_RS02325	COG0456	acetyltransferase
C2H93_RS02330	COG2130	NADP-dependent
C2H93_RS02335	COG1120	ATPase activity
C2H93_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS02345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS02350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H93_RS02365	COG3866	Pectate lyase
C2H93_RS02370	COG0471	metal ion transport
C2H93_RS02375	COG3290	protein histidine kinase activity
C2H93_RS02380	COG4565	transcriptional regulatory protein
C2H93_RS02385	COG3181	Tripartite tricarboxylate transporter family receptor
C2H93_RS02390	COG2851	Citrate transporter
C2H93_RS02395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS02400	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2H93_RS02405	COG1254	Belongs to the acylphosphatase family
C2H93_RS02410	COG2258	MOSC domain
C2H93_RS02430	COG0024	Methionine aminopeptidase
C2H93_RS02435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS02435	COG1263	PTS System
C2H93_RS02440	COG1368	sulfuric ester hydrolase activity
C2H93_RS02455	COG1115	amino acid carrier protein
C2H93_RS02460	COG0531	amino acid
C2H93_RS02475	COG0697	spore germination
C2H93_RS02480	COG1263	PTS System
C2H93_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS02485	COG0366	Alpha amylase catalytic
C2H93_RS02490	COG2188	Transcriptional regulator
C2H93_RS02495	COG0778	Nitroreductase
C2H93_RS02500	COG0737	Belongs to the 5'-nucleotidase family
C2H93_RS02505	COG0693	protein deglycase activity
C2H93_RS02510	COG2814	Major facilitator Superfamily
C2H93_RS02515	COG4840	Belongs to the UPF0435 family
C2H93_RS02520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H93_RS02525	COG4980	gas vesicle protein
C2H93_RS02530	COG1295	ribonuclease BN
C2H93_RS02535	COG0477	Major facilitator Superfamily
C2H93_RS02540	COG0387	Pfam Sodium calcium exchanger
C2H93_RS02550	COG0668	transmembrane transport
C2H93_RS02555	COG0535	radical SAM domain protein
C2H93_RS02565	COG0726	polysaccharide deacetylase
C2H93_RS02570	COG2084	Dehydrogenase
C2H93_RS02575	COG0598	Magnesium transport protein CorA
C2H93_RS02580	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H93_RS02585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H93_RS02595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H93_RS02600	COG4637	Psort location Cytoplasmic, score
C2H93_RS02610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H93_RS02615	COG0022	dehydrogenase e1 component
C2H93_RS02620	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H93_RS02625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H93_RS02630	COG3284	Transcriptional regulator
C2H93_RS02640	COG1742	UPF0060 membrane protein
C2H93_RS02665	COG4842	Belongs to the WXG100 family
C2H93_RS02680	COG5444	nuclease activity
C2H93_RS02695	COG1486	melibiose metabolic process
C2H93_RS02700	COG1737	Transcriptional regulator
C2H93_RS02705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS02705	COG1263	PTS System
C2H93_RS02710	COG1132	(ABC) transporter
C2H93_RS02715	COG1132	(ABC) transporter
C2H93_RS02720	COG2259	Doxx family
C2H93_RS02725	COG2514	catechol 2,3-dioxygenase activity
C2H93_RS02730	COG4585	Histidine kinase
C2H93_RS02735	COG2197	response regulator
C2H93_RS02740	COG1131	(ABC) transporter
C2H93_RS02745	COG0842	Transport permease protein
C2H93_RS02745	COG1511	domain protein
C2H93_RS02750	COG0842	Transport permease protein
C2H93_RS02755	COG1695	Transcriptional regulator
C2H93_RS02760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H93_RS02765	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2H93_RS02770	COG2318	DinB family
C2H93_RS02775	COG2814	Major facilitator Superfamily
C2H93_RS02780	COG1846	Transcriptional regulator
C2H93_RS02785	COG0392	lysyltransferase activity
C2H93_RS02785	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H93_RS02790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS02795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS02800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS02805	COG0384	phenazine biosynthesis protein PhzF
C2H93_RS02810	COG0778	Nitroreductase
C2H93_RS02825	COG1090	epimerase
C2H93_RS02830	COG2137	regulation of response to DNA damage stimulus
C2H93_RS02840	COG2814	Major facilitator Superfamily
C2H93_RS02855	COG3103	Sh3 type 3 domain protein
C2H93_RS02860	COG5658	integral membrane protein
C2H93_RS02865	COG0596	Alpha beta hydrolase
C2H93_RS02870	COG0463	Glycosyl transferase, family 2
C2H93_RS02875	COG4485	Bacterial membrane protein, YfhO
C2H93_RS02880	COG1988	membrane-bound metal-dependent
C2H93_RS02885	COG1194	a g-specific adenine glycosylase
C2H93_RS02895	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS02910	COG3557	Belongs to the UPF0374 family
C2H93_RS02915	COG1132	(ABC) transporter
C2H93_RS02920	COG4129	membrane
C2H93_RS02925	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H93_RS02930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H93_RS02935	COG0735	belongs to the Fur family
C2H93_RS03045	COG4326	sporulation control protein
C2H93_RS03055	COG5577	PFAM Coat F domain
C2H93_RS03060	COG3340	Belongs to the peptidase S51 family
C2H93_RS03065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2H93_RS03080	COG0753	catalase activity
C2H93_RS03085	COG1116	anion transmembrane transporter activity
C2H93_RS03090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H93_RS03095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H93_RS03100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS03110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H93_RS03120	COG1476	TRANSCRIPTIONal
C2H93_RS03130	COG3382	B3 4 domain protein
C2H93_RS03135	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H93_RS03145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H93_RS03150	COG0789	Transcriptional regulator
C2H93_RS03155	COG1664	Polymer-forming cytoskeletal
C2H93_RS03160	COG1664	Polymer-forming cytoskeletal
C2H93_RS03165	COG2766	serine protein kinase
C2H93_RS03170	COG2718	Belongs to the UPF0229 family
C2H93_RS03175	COG1846	Transcriptional regulator
C2H93_RS03180	COG1566	PFAM secretion protein HlyD family protein
C2H93_RS03185	COG2814	Major facilitator Superfamily
C2H93_RS03190	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H93_RS03210	COG1725	Transcriptional regulator
C2H93_RS03215	COG1131	(ABC) transporter
C2H93_RS03220	COG1131	(ABC) transporter
C2H93_RS03225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H93_RS03230	COG1278	Cold shock
C2H93_RS03235	COG1464	Belongs to the NlpA lipoprotein family
C2H93_RS03240	COG3706	GGDEF domain
C2H93_RS03245	COG1823	symporter activity
C2H93_RS03280	COG5577	PFAM Coat F domain
C2H93_RS03285	COG0737	Belongs to the 5'-nucleotidase family
C2H93_RS03285	COG1525	nuclease
C2H93_RS03285	COG4085	toxin activity
C2H93_RS03290	COG3764	Sortase (surface protein transpeptidase)
C2H93_RS03295	COG0564	pseudouridine synthase activity
C2H93_RS03305	COG0517	IMP dehydrogenase activity
C2H93_RS03310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H93_RS03315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H93_RS03315	COG3153	acetyltransferase
C2H93_RS03320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H93_RS03325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H93_RS03330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H93_RS03335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2H93_RS03340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H93_RS03345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H93_RS03350	COG4585	Histidine kinase
C2H93_RS03350	COG2203	Gaf domain
C2H93_RS03355	COG2197	response regulator
C2H93_RS03360	COG0431	NADPH-dependent FMN reductase
C2H93_RS03375	COG0791	NLP P60 protein
C2H93_RS03375	COG1388	LysM domain
C2H93_RS03380	COG1959	2 iron, 2 sulfur cluster binding
C2H93_RS03385	COG0668	transmembrane transport
C2H93_RS03390	COG2719	SpoVR family
C2H93_RS03395	COG1785	Belongs to the alkaline phosphatase family
C2H93_RS03400	COG1388	LysM domain
C2H93_RS03400	COG0791	NLP P60 protein
C2H93_RS03405	COG0583	DNA-binding transcription factor activity
C2H93_RS03410	COG0372	Belongs to the citrate synthase family
C2H93_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS03420	COG0531	amino acid
C2H93_RS03425	COG0733	neurotransmitter:sodium symporter activity
C2H93_RS03430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS03435	COG0456	acetyltransferase
C2H93_RS03450	COG1595	DNA-templated transcription, initiation
C2H93_RS03455	COG0667	Aldo Keto reductase
C2H93_RS03460	COG0204	Acyl-transferase
C2H93_RS03465	COG1253	flavin adenine dinucleotide binding
C2H93_RS03470	COG0789	Transcriptional regulator
C2H93_RS03475	COG0436	Aminotransferase
C2H93_RS03480	COG1253	flavin adenine dinucleotide binding
C2H93_RS03485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H93_RS03490	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H93_RS03495	COG0584	glycerophosphoryl diester phosphodiesterase
C2H93_RS03505	COG0668	transmembrane transport
C2H93_RS03510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H93_RS03515	COG0726	polysaccharide deacetylase
C2H93_RS03520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H93_RS03525	COG1757	Na H antiporter
C2H93_RS03530	COG0589	response to stress
C2H93_RS03540	COG1132	(ABC) transporter
C2H93_RS03545	COG1132	(ABC) transporter
C2H93_RS03550	COG0702	epimerase
C2H93_RS03570	COG0189	ligase activity
C2H93_RS03575	COG0189	ligase activity
C2H93_RS03580	COG4399	Belongs to the UPF0754 family
C2H93_RS03585	COG3679	Belongs to the UPF0342 family
C2H93_RS03590	COG4335	DNA alkylation repair
C2H93_RS03595	COG0561	phosphatase activity
C2H93_RS03600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H93_RS03605	COG0475	glutathione-regulated potassium exporter activity
C2H93_RS03610	COG0490	domain, Protein
C2H93_RS03620	COG1024	Enoyl-CoA hydratase
C2H93_RS03630	COG4152	abc transporter atp-binding protein
C2H93_RS03635	COG1668	transmembrane transport
C2H93_RS03640	COG0420	3'-5' exonuclease activity
C2H93_RS03645	COG4717	serine-type aminopeptidase activity
C2H93_RS03650	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2H93_RS03660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H93_RS03690	COG1846	Transcriptional regulator
C2H93_RS03695	COG4980	gas vesicle protein
C2H93_RS03710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H93_RS03715	COG0537	adenosine 5'-monophosphoramidase activity
C2H93_RS03720	COG1131	(ABC) transporter
C2H93_RS03725	COG4473	ABC transporter
C2H93_RS03735	COG1473	amidohydrolase
C2H93_RS03740	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H93_RS03750	COG2329	Antibiotic biosynthesis monooxygenase
C2H93_RS03755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H93_RS03760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H93_RS03765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2H93_RS03770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2H93_RS03775	COG1309	transcriptional regulator
C2H93_RS03780	COG1511	domain protein
C2H93_RS03785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H93_RS03790	COG4377	Putative membrane peptidase family (DUF2324)
C2H93_RS03800	COG1363	Peptidase, m42
C2H93_RS03805	COG4405	Protein conserved in bacteria
C2H93_RS03810	COG1301	dicarboxylic acid transport
C2H93_RS03820	COG1234	tRNA 3'-trailer cleavage
C2H93_RS03825	COG0095	Lipoate-protein ligase
C2H93_RS03830	COG0702	epimerase
C2H93_RS03835	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS03845	COG0501	Belongs to the peptidase M48B family
C2H93_RS03850	COG1404	Belongs to the peptidase S8 family
C2H93_RS03855	COG0456	acetyltransferase
C2H93_RS03860	COG0604	alcohol dehydrogenase
C2H93_RS03865	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H93_RS03870	COG0406	alpha-ribazole phosphatase activity
C2H93_RS03875	COG0183	Belongs to the thiolase family
C2H93_RS03880	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS03885	COG1268	BioY protein
C2H93_RS03890	COG0840	transmembrane signaling receptor activity
C2H93_RS03895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H93_RS03895	COG0723	plastoquinol--plastocyanin reductase activity
C2H93_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS03910	COG4903	ComK protein
C2H93_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS03925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H93_RS03940	COG0398	Pfam SNARE associated Golgi protein
C2H93_RS03945	COG0681	Belongs to the peptidase S26 family
C2H93_RS03950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H93_RS03955	COG1846	Transcriptional regulator
C2H93_RS03960	COG0738	Major facilitator superfamily
C2H93_RS03965	COG0673	inositol 2-dehydrogenase activity
C2H93_RS03970	COG0561	phosphatase activity
C2H93_RS03975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H93_RS03980	COG1609	Transcriptional regulator
C2H93_RS03985	COG3180	Ammonia monooxygenase
C2H93_RS03990	COG2814	Major facilitator Superfamily
C2H93_RS03990	COG0477	Major facilitator Superfamily
C2H93_RS03995	COG4533	DNA binding
C2H93_RS04005	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2H93_RS04010	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H93_RS04015	COG1074	ATP-dependent DNA helicase activity
C2H93_RS04020	COG0420	3'-5' exonuclease activity
C2H93_RS04025	COG0419	ATPase involved in DNA repair
C2H93_RS04030	COG1403	HNH endonuclease
C2H93_RS04070	COG5337	Spore coat protein CotH
C2H93_RS04075	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H93_RS04085	COG1404	Belongs to the peptidase S8 family
C2H93_RS04095	COG0367	asparagine synthase
C2H93_RS04100	COG2318	DinB family
C2H93_RS04110	COG0534	Mate efflux family protein
C2H93_RS04115	COG2207	Transcriptional regulator
C2H93_RS04115	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS04120	COG1609	Transcriptional regulator
C2H93_RS04125	COG0673	inositol 2-dehydrogenase activity
C2H93_RS04130	COG2318	DinB family
C2H93_RS04140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H93_RS04145	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H93_RS04150	COG2267	carboxylic ester hydrolase activity
C2H93_RS04155	COG0529	Catalyzes the synthesis of activated sulfate
C2H93_RS04160	COG2046	Belongs to the sulfate adenylyltransferase family
C2H93_RS04165	COG0175	sulfate reduction
C2H93_RS04170	COG2045	Belongs to the ComB family
C2H93_RS04175	COG1809	phosphosulfolactate synthase activity
C2H93_RS04180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS04185	COG4948	Mandelate Racemase Muconate Lactonizing
C2H93_RS04190	COG2814	Major facilitator Superfamily
C2H93_RS04195	COG0454	-acetyltransferase
C2H93_RS04200	COG2153	protein acetylation
C2H93_RS04205	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H93_RS04205	COG0646	methionine synthase
C2H93_RS04210	COG1666	GTP binding
C2H93_RS04215	COG2996	Protein conserved in bacteria
C2H93_RS04235	COG1695	Transcriptional regulator
C2H93_RS04250	COG3227	Zinc metalloprotease (Elastase)
C2H93_RS04255	COG1307	EDD domain protein, DegV family
C2H93_RS04260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS04280	COG0561	phosphatase activity
C2H93_RS04285	COG1073	alpha beta
C2H93_RS04290	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H93_RS04300	COG0277	FAD linked oxidase domain protein
C2H93_RS04305	COG2271	Major facilitator Superfamily
C2H93_RS04310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H93_RS04315	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H93_RS04325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H93_RS04330	COG0505	Belongs to the CarA family
C2H93_RS04335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H93_RS04340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H93_RS04355	COG2267	carboxylic ester hydrolase activity
C2H93_RS04365	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H93_RS04380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H93_RS04385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H93_RS04390	COG5504	Zn-dependent protease
C2H93_RS04395	COG0444	Belongs to the ABC transporter superfamily
C2H93_RS04400	COG4608	Belongs to the ABC transporter superfamily
C2H93_RS04410	COG0601	transmembrane transport
C2H93_RS04415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H93_RS04425	COG0180	Tryptophanyl-tRNA synthetase
C2H93_RS04430	COG4166	transmembrane transport
C2H93_RS04435	COG0601	transmembrane transport
C2H93_RS04440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H93_RS04445	COG0444	Belongs to the ABC transporter superfamily
C2H93_RS04450	COG4608	Belongs to the ABC transporter superfamily
C2H93_RS04455	COG2814	Major facilitator Superfamily
C2H93_RS04460	COG0456	acetyltransferase
C2H93_RS04465	COG1393	Belongs to the ArsC family
C2H93_RS04470	COG0861	Integral membrane protein TerC family
C2H93_RS04480	COG4862	establishment of competence for transformation
C2H93_RS04490	COG4469	Competence protein
C2H93_RS04495	COG1164	Oligoendopeptidase f
C2H93_RS04505	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H93_RS04510	COG2346	COG2346, Truncated hemoglobins
C2H93_RS04515	COG0741	lytic transglycosylase activity
C2H93_RS04520	COG4116	CYTH
C2H93_RS04530	COG2357	RelA SpoT domain protein
C2H93_RS04535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H93_RS04540	COG0564	pseudouridine synthase activity
C2H93_RS04545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H93_RS04550	COG0569	domain protein
C2H93_RS04550	COG0475	glutathione-regulated potassium exporter activity
C2H93_RS04555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H93_RS04560	COG0352	thiamine-phosphate diphosphorylase activity
C2H93_RS04565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H93_RS04570	COG2104	thiamine diphosphate biosynthetic process
C2H93_RS04575	COG2022	thiamine diphosphate biosynthetic process
C2H93_RS04580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H93_RS04585	COG0351	phosphomethylpyrimidine kinase
C2H93_RS04590	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H93_RS04645	COG0210	DNA helicase
C2H93_RS04655	COG2153	protein acetylation
C2H93_RS04660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H93_RS04665	COG2382	esterase
C2H93_RS04670	COG0626	cystathionine gamma-synthase activity
C2H93_RS04675	COG0626	cystathionine gamma-synthase activity
C2H93_RS04680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS04685	COG5505	Protein of unknown function (DUF819)
C2H93_RS04720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H93_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS04735	COG3711	transcriptional antiterminator
C2H93_RS04735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS04740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H93_RS04740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS04740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H93_RS04745	COG1482	cell wall glycoprotein biosynthetic process
C2H93_RS04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS04765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H93_RS04780	COG0109	protoheme IX farnesyltransferase activity
C2H93_RS04790	COG0726	polysaccharide deacetylase
C2H93_RS04805	COG5504	Zn-dependent protease
C2H93_RS04810	COG2205	protein histidine kinase activity
C2H93_RS04820	COG3383	formate dehydrogenase (NAD+) activity
C2H93_RS04825	COG2427	Protein of unknown function (DUF1641)
C2H93_RS04835	COG1051	belongs to the nudix hydrolase family
C2H93_RS04845	COG2124	cytochrome p450
C2H93_RS04850	COG1819	glycosyl
C2H93_RS04860	COG1587	Uroporphyrinogen-III synthase
C2H93_RS04865	COG0390	transport system, permease component
C2H93_RS04870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H93_RS04875	COG0697	spore germination
C2H93_RS04880	COG4297	protein containing double-stranded beta helix domain
C2H93_RS04890	COG1252	NADH dehydrogenase
C2H93_RS04895	COG1904	glucuronate isomerase
C2H93_RS04900	COG2211	Major facilitator Superfamily
C2H93_RS04905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H93_RS04910	COG1063	alcohol dehydrogenase
C2H93_RS04915	COG1312	Catalyzes the dehydration of D-mannonate
C2H93_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS04925	COG2271	Major facilitator Superfamily
C2H93_RS04930	COG1609	Transcriptional regulator
C2H93_RS04935	COG0246	Mannitol dehydrogenase
C2H93_RS04940	COG2721	sulfolactate sulfo-lyase activity
C2H93_RS04945	COG0730	response to heat
C2H93_RS04950	COG2318	DinB family
C2H93_RS04960	COG0457	Tetratricopeptide repeat
C2H93_RS04975	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS04975	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS04975	COG1388	LysM domain
C2H93_RS04985	COG4195	phage-related replication protein
C2H93_RS04990	COG3546	catalase activity
C2H93_RS04995	COG2856	Zn peptidase
C2H93_RS05000	COG1396	sequence-specific DNA binding
C2H93_RS05010	COG1522	sequence-specific DNA binding
C2H93_RS05015	COG1484	DNA-dependent DNA replication
C2H93_RS05035	COG1595	DNA-templated transcription, initiation
C2H93_RS05040	COG5484	DNA packaging
C2H93_RS05040	COG3728	DNA packaging
C2H93_RS05045	COG1783	phage Terminase large subunit
C2H93_RS05050	COG5518	Phage portal protein
C2H93_RS05055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H93_RS05060	COG4653	Phage capsid family
C2H93_RS05110	COG5412	phage tail tape measure protein
C2H93_RS05110	COG3953	SLT domain
C2H93_RS05115	COG1652	LysM domain
C2H93_RS05120	COG4193	domain, Protein
C2H93_RS05130	COG3628	GPW Gp25 family protein
C2H93_RS05135	COG3299	homolog of phage Mu protein gp47
C2H93_RS05140	COG3778	Protein conserved in bacteria
C2H93_RS05180	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS05180	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS05200	COG0306	phosphate transporter
C2H93_RS05205	COG1392	Phosphate transport regulator
C2H93_RS05210	COG0531	amino acid
C2H93_RS05215	COG0346	lactoylglutathione lyase activity
C2H93_RS05225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H93_RS05230	COG0463	Glycosyl transferase, family 2
C2H93_RS05240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H93_RS05245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H93_RS05250	COG2362	D-Aminopeptidase
C2H93_RS05255	COG0601	transmembrane transport
C2H93_RS05260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H93_RS05265	COG0444	Belongs to the ABC transporter superfamily
C2H93_RS05270	COG4166	transmembrane transport
C2H93_RS05275	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H93_RS05280	COG4948	Mandelate Racemase Muconate Lactonizing
C2H93_RS05285	COG0791	NLP P60 protein
C2H93_RS05290	COG4608	Belongs to the ABC transporter superfamily
C2H93_RS05295	COG2706	6-phosphogluconolactonase activity
C2H93_RS05300	COG1834	amidinotransferase
C2H93_RS05305	COG1607	acyl-coa hydrolase
C2H93_RS05310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H93_RS05310	COG1017	nitric oxide dioxygenase activity
C2H93_RS05320	COG2323	membrane
C2H93_RS05325	COG2318	DinB family
C2H93_RS05330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS05335	COG2076	Multidrug Resistance protein
C2H93_RS05340	COG2076	Multidrug Resistance protein
C2H93_RS05345	COG0788	formyltetrahydrofolate deformylase activity
C2H93_RS05350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H93_RS05355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H93_RS05360	COG1764	response to oxidative stress
C2H93_RS05365	COG1846	Transcriptional regulator
C2H93_RS05370	COG1764	response to oxidative stress
C2H93_RS05380	COG0590	tRNA wobble adenosine to inosine editing
C2H93_RS05385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H93_RS05390	COG1404	Belongs to the peptidase S8 family
C2H93_RS05395	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS05400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H93_RS05405	COG1122	ATPase activity
C2H93_RS05410	COG4721	ABC-type cobalt transport system, permease component
C2H93_RS05420	COG0745	RESPONSE REGULATOR receiver
C2H93_RS05425	COG5002	protein histidine kinase activity
C2H93_RS05425	COG3850	Histidine kinase
C2H93_RS05430	COG3212	peptidase
C2H93_RS05435	COG3212	peptidase
C2H93_RS05445	COG2239	Acts as a magnesium transporter
C2H93_RS05450	COG0789	Transcriptional regulator
C2H93_RS05465	COG1846	Transcriptional regulator
C2H93_RS05470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H93_RS05475	COG0726	polysaccharide deacetylase
C2H93_RS05480	COG1408	metallophosphoesterase
C2H93_RS05490	COG0463	Glycosyl transferase, family 2
C2H93_RS05495	COG3285	dna ligase
C2H93_RS05495	COG1793	dna ligase
C2H93_RS05500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H93_RS05505	COG5001	Diguanylate cyclase
C2H93_RS05505	COG3300	MHYT domain
C2H93_RS05510	COG0586	Pfam SNARE associated Golgi protein
C2H93_RS05515	COG0861	Integral membrane protein TerC family
C2H93_RS05520	COG1191	sigma factor activity
C2H93_RS05540	COG0501	Belongs to the peptidase M48B family
C2H93_RS05545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H93_RS05560	COG3594	Acyltransferase
C2H93_RS05565	COG5002	protein histidine kinase activity
C2H93_RS05570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H93_RS05580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2H93_RS05585	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2H93_RS05590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H93_RS05595	COG0436	Aminotransferase
C2H93_RS05600	COG1850	ribulose-bisphosphate carboxylase activity
C2H93_RS05605	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2H93_RS05610	COG0235	Class ii aldolase
C2H93_RS05615	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2H93_RS05620	COG3339	Conserved Protein
C2H93_RS05635	COG3852	Histidine kinase
C2H93_RS05640	COG1846	Transcriptional regulator
C2H93_RS05645	COG1360	Flagellar Motor Protein
C2H93_RS05650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H93_RS05655	COG0542	response to heat
C2H93_RS05660	COG3949	Membrane
C2H93_RS05665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2H93_RS05670	COG0720	synthase
C2H93_RS05675	COG0602	queuosine metabolic process
C2H93_RS05680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H93_RS05685	COG1733	regulation of RNA biosynthetic process
C2H93_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS05695	COG4641	Protein conserved in bacteria
C2H93_RS05695	COG1388	LysM domain
C2H93_RS05700	COG1388	LysM domain
C2H93_RS05705	COG3858	chitin binding
C2H93_RS05715	COG4873	Protein conserved in bacteria
C2H93_RS05725	COG3773	Cell wall hydrolase
C2H93_RS05730	COG2244	polysaccharide biosynthetic process
C2H93_RS05735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS05740	COG2217	Heavy metal translocating P-type atpase
C2H93_RS05750	COG0006	proline dipeptidase activity
C2H93_RS05755	COG1609	Transcriptional regulator
C2H93_RS05760	COG3711	transcriptional antiterminator
C2H93_RS05765	COG2190	(PTS) system
C2H93_RS05765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS05765	COG1263	PTS System
C2H93_RS05770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS05775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H93_RS05785	COG1533	DNA photolyase activity
C2H93_RS05790	COG0456	acetyltransferase
C2H93_RS05795	COG0840	transmembrane signaling receptor activity
C2H93_RS05800	COG2084	Dehydrogenase
C2H93_RS05805	COG4257	antibiotic catabolic process
C2H93_RS05810	COG2340	Cysteine-rich secretory protein family
C2H93_RS05815	COG0768	penicillin binding
C2H93_RS05820	COG4191	Histidine kinase
C2H93_RS05825	COG0436	Aminotransferase
C2H93_RS05835	COG0784	Response regulator, receiver
C2H93_RS05835	COG0835	chemotaxis
C2H93_RS05845	COG2814	Major facilitator Superfamily
C2H93_RS05850	COG1376	ErfK ybiS ycfS ynhG family protein
C2H93_RS05855	COG1408	metallophosphoesterase
C2H93_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS05865	COG2200	EAL domain
C2H93_RS05870	COG4703	Protein of unknown function (DUF1797)
C2H93_RS05875	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H93_RS05885	COG0517	IMP dehydrogenase activity
C2H93_RS05890	COG0583	DNA-binding transcription factor activity
C2H93_RS05895	COG0716	FMN binding
C2H93_RS05905	COG0716	FMN binding
C2H93_RS05910	COG2171	N-acyltransferase activity
C2H93_RS05915	COG1473	amidohydrolase
C2H93_RS05925	COG0668	transmembrane transport
C2H93_RS05930	COG0450	alkyl hydroperoxide reductase
C2H93_RS05935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS05950	COG0746	molybdenum cofactor guanylyltransferase activity
C2H93_RS05955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H93_RS05960	COG0303	'Molybdopterin
C2H93_RS05965	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H93_RS05970	COG0314	molybdopterin synthase activity
C2H93_RS05975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H93_RS05980	COG1132	(ABC) transporter
C2H93_RS05985	COG1132	(ABC) transporter
C2H93_RS05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H93_RS06000	COG1136	(ABC) transporter
C2H93_RS06005	COG0577	efflux transmembrane transporter activity
C2H93_RS06010	COG1349	DNA-binding transcription factor activity
C2H93_RS06015	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H93_RS06020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS06020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H93_RS06020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H93_RS06025	COG0681	Belongs to the peptidase S26 family
C2H93_RS06035	COG0488	(ABC) transporter
C2H93_RS06040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H93_RS06045	COG2309	aminopeptidase activity
C2H93_RS06055	COG1077	Cell shape determining protein MreB Mrl
C2H93_RS06060	COG2002	toxin-antitoxin pair type II binding
C2H93_RS06065	COG3852	Histidine kinase
C2H93_RS06070	COG2105	PFAM AIG2 family protein
C2H93_RS06070	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H93_RS06075	COG0569	domain protein
C2H93_RS06080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H93_RS06085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H93_RS06090	COG5503	Protein of unknown function (DUF1447)
C2H93_RS06095	COG0561	phosphatase activity
C2H93_RS06100	COG0242	peptide deformylase activity
C2H93_RS06110	COG0497	DNA recombination
C2H93_RS06115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H93_RS06120	COG0022	dehydrogenase e1 component
C2H93_RS06125	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H93_RS06130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H93_RS06135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS06145	COG1982	Orn Lys Arg decarboxylase major
C2H93_RS06150	COG4476	Belongs to the UPF0223 family
C2H93_RS06155	COG4493	Belongs to the UPF0637 family
C2H93_RS06165	COG0483	inositol monophosphate 1-phosphatase activity
C2H93_RS06175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H93_RS06195	COG1595	DNA-templated transcription, initiation
C2H93_RS06215	COG1217	gtp-binding protein TYPA
C2H93_RS06225	COG4896	Protein conserved in bacteria
C2H93_RS06235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H93_RS06240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H93_RS06245	COG2066	Belongs to the glutaminase family
C2H93_RS06250	COG4838	Belongs to the UPF0358 family
C2H93_RS06255	COG0772	Belongs to the SEDS family
C2H93_RS06260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2H93_RS06265	COG1612	heme a metabolic process
C2H93_RS06270	COG0109	protoheme IX farnesyltransferase activity
C2H93_RS06275	COG2010	Cytochrome c
C2H93_RS06275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H93_RS06280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H93_RS06285	COG1845	cytochrome c oxidase, subunit III
C2H93_RS06290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H93_RS06295	COG3336	cytochrome c oxidase
C2H93_RS06305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2H93_RS06310	COG2340	Cysteine-rich secretory protein family
C2H93_RS06325	COG3679	Belongs to the UPF0342 family
C2H93_RS06330	COG4471	UPF0298 protein
C2H93_RS06335	COG0742	ribosomal rna small subunit methyltransferase
C2H93_RS06340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H93_RS06345	COG3314	Sporulation integral membrane protein YlbJ
C2H93_RS06350	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H93_RS06355	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H93_RS06360	COG1323	Belongs to the UPF0348 family
C2H93_RS06370	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H93_RS06385	COG0454	-acetyltransferase
C2H93_RS06390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H93_RS06395	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H93_RS06400	COG2001	Belongs to the MraZ family
C2H93_RS06405	COG0275	rRNA processing
C2H93_RS06410	COG4839	cell division protein FtsL
C2H93_RS06415	COG0768	penicillin binding
C2H93_RS06420	COG0768	penicillin binding
C2H93_RS06425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H93_RS06430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H93_RS06435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H93_RS06440	COG0772	Belongs to the SEDS family
C2H93_RS06445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H93_RS06450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H93_RS06455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H93_RS06460	COG3879	Bacterial protein of unknown function (DUF881)
C2H93_RS06465	COG3879	Bacterial protein of unknown function (DUF881)
C2H93_RS06470	COG3856	small basic protein
C2H93_RS06475	COG0849	cell division
C2H93_RS06480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H93_RS06485	COG1404	Belongs to the peptidase S8 family
C2H93_RS06485	COG4412	M6 family metalloprotease domain protein
C2H93_RS06495	COG1191	sigma factor activity
C2H93_RS06500	COG1191	sigma factor activity
C2H93_RS06505	COG1119	ATPase activity
C2H93_RS06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H93_RS06515	COG1873	PFAM PRC-barrel domain
C2H93_RS06520	COG1496	oxidoreductase activity
C2H93_RS06525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H93_RS06530	COG1799	cell septum assembly
C2H93_RS06535	COG0762	integral membrane protein
C2H93_RS06540	COG2302	S4 RNA-binding domain
C2H93_RS06545	COG3599	regulation of cell shape
C2H93_RS06550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H93_RS06555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H93_RS06560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H93_RS06565	COG0564	pseudouridine synthase activity
C2H93_RS06570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H93_RS06575	COG2233	PERMEase
C2H93_RS06580	COG0540	Belongs to the ATCase OTCase family
C2H93_RS06585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H93_RS06590	COG0505	Belongs to the CarA family
C2H93_RS06595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H93_RS06600	COG0543	2 iron, 2 sulfur cluster binding
C2H93_RS06605	COG0167	dihydroorotate dehydrogenase activity
C2H93_RS06610	COG0284	orotidine-5'-phosphate decarboxylase activity
C2H93_RS06615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2H93_RS06620	COG0175	sulfate reduction
C2H93_RS06625	COG0306	phosphate transporter
C2H93_RS06630	COG2046	Belongs to the sulfate adenylyltransferase family
C2H93_RS06635	COG0529	Catalyzes the synthesis of activated sulfate
C2H93_RS06640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H93_RS06645	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2H93_RS06650	COG1648	precorrin-2 dehydrogenase activity
C2H93_RS06655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2H93_RS06660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H93_RS06665	COG1561	YicC-like family, N-terminal region
C2H93_RS06675	COG0194	GDP metabolic process
C2H93_RS06680	COG1758	RNA polymerase activity
C2H93_RS06685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H93_RS06690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H93_RS06695	COG0242	peptide deformylase activity
C2H93_RS06700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H93_RS06705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H93_RS06705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H93_RS06710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2H93_RS06715	COG0631	protein serine/threonine phosphatase activity
C2H93_RS06720	COG0515	serine threonine protein kinase
C2H93_RS06720	COG2815	serine threonine protein kinase
C2H93_RS06725	COG1162	GTPase activity
C2H93_RS06730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H93_RS06735	COG1564	THIamine pyrophosphokinase
C2H93_RS06745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H93_RS06750	COG1302	Protein conserved in bacteria
C2H93_RS06755	COG1461	Dihydroxyacetone kinase
C2H93_RS06760	COG1760	l-serine dehydratase
C2H93_RS06765	COG1760	l-serine dehydratase
C2H93_RS06770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H93_RS06775	COG1349	DNA-binding transcription factor activity
C2H93_RS06775	COG2050	protein possibly involved in aromatic compounds catabolism
C2H93_RS06780	COG0416	fatty acid biosynthetic process
C2H93_RS06785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H93_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS06800	COG0571	ribonuclease III activity
C2H93_RS06805	COG1196	nuclear chromosome segregation
C2H93_RS06810	COG0552	protein localization to endoplasmic reticulum
C2H93_RS06820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2H93_RS06825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H93_RS06830	COG0228	four-way junction DNA binding
C2H93_RS06835	COG1837	Belongs to the UPF0109 family
C2H93_RS06845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H93_RS06850	COG0336	Belongs to the RNA methyltransferase TrmD family
C2H93_RS06855	COG0335	large ribosomal subunit rRNA binding
C2H93_RS06860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H93_RS06865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H93_RS06875	COG2257	FlhB HrpN YscU SpaS Family
C2H93_RS06880	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H93_RS06885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H93_RS06890	COG0758	DNA mediated transformation
C2H93_RS06895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H93_RS06900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2H93_RS06905	COG4974	Belongs to the 'phage' integrase family
C2H93_RS06910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2H93_RS06915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H93_RS06920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H93_RS06925	COG1815	bacterial-type flagellum-dependent cell motility
C2H93_RS06930	COG1558	bacterial-type flagellum-dependent cell motility
C2H93_RS06935	COG1677	Flagellar hook-basal body complex protein FliE
C2H93_RS06940	COG1766	The M ring may be actively involved in energy transduction
C2H93_RS06945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H93_RS06950	COG1317	bacterial-type flagellum organization
C2H93_RS06955	COG1157	protein secretion by the type III secretion system
C2H93_RS06960	COG2882	bacterial-type flagellum organization
C2H93_RS06965	COG3334	PFAM MgtE intracellular
C2H93_RS06970	COG3144	bacterial-type flagellum assembly
C2H93_RS06975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H93_RS06980	COG4786	Flagellar basal body rod
C2H93_RS06985	COG1582	Flagellar protein (FlbD)
C2H93_RS06990	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H93_RS06995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H93_RS07000	COG1776	CheC inhibitor of MCP methylation
C2H93_RS07000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H93_RS07005	COG2201	protein-glutamate methylesterase activity
C2H93_RS07010	COG3190	flagellar
C2H93_RS07015	COG1338	Plays a role in the flagellum-specific transport system
C2H93_RS07020	COG1987	bacterial-type flagellum assembly
C2H93_RS07025	COG1684	flagellar biosynthetic protein fliR
C2H93_RS07030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H93_RS07035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H93_RS07040	COG1419	protein localization to endoplasmic reticulum
C2H93_RS07045	COG0455	bacterial-type flagellum organization
C2H93_RS07050	COG2201	protein-glutamate methylesterase activity
C2H93_RS07055	COG0643	Histidine kinase
C2H93_RS07055	COG2198	Histidine kinase
C2H93_RS07060	COG0835	chemotaxis
C2H93_RS07065	COG1776	CheC inhibitor of MCP methylation
C2H93_RS07070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H93_RS07075	COG1191	sigma factor activity
C2H93_RS07085	COG0052	Belongs to the universal ribosomal protein uS2 family
C2H93_RS07090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2H93_RS07095	COG0528	UMP kinase activity
C2H93_RS07100	COG0233	cytoplasmic translational termination
C2H93_RS07105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H93_RS07110	COG4589	Belongs to the CDS family
C2H93_RS07115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H93_RS07120	COG0750	zinc metalloprotease
C2H93_RS07125	COG0442	prolyl-tRNA aminoacylation
C2H93_RS07130	COG2176	DNA-directed DNA polymerase activity
C2H93_RS07135	COG0779	Required for maturation of 30S ribosomal subunits
C2H93_RS07140	COG0195	Participates in both transcription termination and antitermination
C2H93_RS07145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H93_RS07150	COG1358	cellular component organization or biogenesis
C2H93_RS07155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2H93_RS07160	COG1550	Protein conserved in bacteria
C2H93_RS07165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2H93_RS07170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H93_RS07175	COG0196	riboflavin kinase activity
C2H93_RS07180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H93_RS07185	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H93_RS07190	COG0726	polysaccharide deacetylase
C2H93_RS07195	COG0612	Peptidase, M16
C2H93_RS07200	COG1873	PFAM PRC-barrel domain
C2H93_RS07205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H93_RS07210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H93_RS07215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H93_RS07220	COG0527	aspartate kinase activity
C2H93_RS07225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H93_RS07230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H93_RS07235	COG0740	serine-type endopeptidase activity
C2H93_RS07245	COG1674	ftsk spoiiie
C2H93_RS07245	COG4980	gas vesicle protein
C2H93_RS07250	COG2188	Transcriptional regulator
C2H93_RS07255	COG2814	Major facilitator Superfamily
C2H93_RS07260	COG0612	Peptidase, M16
C2H93_RS07265	COG0612	Peptidase, M16
C2H93_RS07270	COG0300	oxidoreductase activity
C2H93_RS07285	COG1426	Protein conserved in bacteria
C2H93_RS07290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H93_RS07295	COG1058	Belongs to the CinA family
C2H93_RS07295	COG1546	Belongs to the CinA family
C2H93_RS07300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H93_RS07305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H93_RS07310	COG1418	mRNA catabolic process
C2H93_RS07315	COG1692	metallophosphoesterase
C2H93_RS07320	COG2359	stage V sporulation protein S
C2H93_RS07325	COG1063	alcohol dehydrogenase
C2H93_RS07330	COG0156	8-amino-7-oxononanoate synthase activity
C2H93_RS07335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H93_RS07340	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H93_RS07350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H93_RS07355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H93_RS07370	COG3226	Transcriptional regulator
C2H93_RS07375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS07385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H93_RS07390	COG3321	synthase
C2H93_RS07395	COG2070	2-Nitropropane dioxygenase
C2H93_RS07395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H93_RS07400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H93_RS07405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H93_RS07410	COG3425	synthase
C2H93_RS07415	COG1024	Enoyl-CoA hydratase
C2H93_RS07420	COG1024	Enoyl-CoA hydratase
C2H93_RS07425	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS07425	COG0300	oxidoreductase activity
C2H93_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS07425	COG3321	synthase
C2H93_RS07425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS07430	COG4221	oxidoreductase activity
C2H93_RS07430	COG3321	synthase
C2H93_RS07430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H93_RS07430	COG0300	oxidoreductase activity
C2H93_RS07435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H93_RS07435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H93_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS07435	COG3321	synthase
C2H93_RS07435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS07440	COG4221	oxidoreductase activity
C2H93_RS07440	COG3321	synthase
C2H93_RS07440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS07440	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS07445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H93_RS07445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H93_RS07445	COG3321	synthase
C2H93_RS07445	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H93_RS07450	COG2124	cytochrome p450
C2H93_RS07460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS07465	COG1404	Belongs to the peptidase S8 family
C2H93_RS07475	COG4195	phage-related replication protein
C2H93_RS07480	COG1764	response to oxidative stress
C2H93_RS07485	COG2076	Multidrug Resistance protein
C2H93_RS07490	COG2076	Multidrug Resistance protein
C2H93_RS07505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H93_RS07510	COG1923	regulation of RNA biosynthetic process
C2H93_RS07525	COG1780	Probably involved in ribonucleotide reductase function
C2H93_RS07530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H93_RS07535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H93_RS07540	COG4112	unkown
C2H93_RS07545	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS07550	COG0464	growth
C2H93_RS07555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H93_RS07560	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H93_RS07565	COG0789	Transcriptional regulator
C2H93_RS07570	COG0174	glutamine synthetase
C2H93_RS07595	COG4282	regulation of fungal-type cell wall biogenesis
C2H93_RS07605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS07640	COG2211	Major facilitator Superfamily
C2H93_RS07645	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H93_RS07650	COG1940	carbohydrate kinase activity
C2H93_RS07655	COG2115	Belongs to the xylose isomerase family
C2H93_RS07660	COG1070	Carbohydrate kinase
C2H93_RS07670	COG1525	nuclease
C2H93_RS07680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H93_RS07690	COG0756	dUTP diphosphatase activity
C2H93_RS07730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H93_RS07745	COG3832	glyoxalase III activity
C2H93_RS07755	COG0697	spore germination
C2H93_RS07760	COG0531	amino acid
C2H93_RS07790	COG4195	phage-related replication protein
C2H93_RS07805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H93_RS07810	COG1388	LysM domain
C2H93_RS07815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H93_RS07820	COG4224	UPF0291 protein
C2H93_RS07825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H93_RS07835	COG3763	UPF0154 protein
C2H93_RS07845	COG0785	Cytochrome C biogenesis protein
C2H93_RS07850	COG2201	protein-glutamate methylesterase activity
C2H93_RS07855	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H93_RS07865	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H93_RS07880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H93_RS07885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS07905	COG0824	Thioesterase
C2H93_RS07915	COG4841	protein insertion into membrane
C2H93_RS07920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H93_RS07925	COG1832	CoA-binding protein
C2H93_RS07930	COG0187	DNA topoisomerase II activity
C2H93_RS07935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H93_RS07945	COG1115	amino acid carrier protein
C2H93_RS07950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2H93_RS07960	COG5520	Belongs to the glycosyl hydrolase 30 family
C2H93_RS07965	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H93_RS07970	COG2246	polysaccharide biosynthetic process
C2H93_RS07975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H93_RS07980	COG0586	Pfam SNARE associated Golgi protein
C2H93_RS07985	COG2404	hydrolase activity, acting on ester bonds
C2H93_RS07990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H93_RS07995	COG1024	Enoyl-CoA hydratase
C2H93_RS08000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H93_RS08005	COG0511	ligase activity, forming carbon-carbon bonds
C2H93_RS08010	COG0439	Biotin carboxylase
C2H93_RS08015	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS08020	COG1960	acyl-CoA dehydrogenase activity
C2H93_RS08040	COG1649	PFAM Uncharacterised BCR, COG1649
C2H93_RS08050	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H93_RS08050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS08055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS08060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS08065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS08070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS08075	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H93_RS08080	COG2017	converts alpha-aldose to the beta-anomer
C2H93_RS08085	COG0534	Mate efflux family protein
C2H93_RS08100	COG0582	viral genome integration into host DNA
C2H93_RS08105	COG0166	Belongs to the GPI family
C2H93_RS08110	COG0405	Gamma-glutamyltransferase
C2H93_RS08115	COG0583	DNA-binding transcription factor activity
C2H93_RS08120	COG0604	alcohol dehydrogenase
C2H93_RS08125	COG0493	'glutamate synthase
C2H93_RS08130	COG0070	glutamate synthase
C2H93_RS08130	COG0069	glutamate synthase activity
C2H93_RS08130	COG0067	glutamate synthase
C2H93_RS08135	COG0583	DNA-binding transcription factor activity
C2H93_RS08140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H93_RS08145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H93_RS08155	COG0300	oxidoreductase activity
C2H93_RS08160	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H93_RS08170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS08185	COG1131	(ABC) transporter
C2H93_RS08195	COG2814	Major facilitator Superfamily
C2H93_RS08200	COG1070	Carbohydrate kinase
C2H93_RS08205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H93_RS08210	COG0243	molybdopterin cofactor binding
C2H93_RS08220	COG2814	Major facilitator Superfamily
C2H93_RS08225	COG0673	inositol 2-dehydrogenase activity
C2H93_RS08230	COG1082	Xylose isomerase domain protein TIM barrel
C2H93_RS08235	COG1609	Transcriptional regulator
C2H93_RS08250	COG5278	phosphoserine phosphatase activity
C2H93_RS08250	COG0840	transmembrane signaling receptor activity
C2H93_RS08255	COG2368	4-hydroxyphenylacetate
C2H93_RS08260	COG4305	rare lipoprotein A
C2H93_RS08265	COG3619	membrane
C2H93_RS08270	COG3866	Pectate lyase
C2H93_RS08275	COG2135	peptidase activity
C2H93_RS08315	COG2720	vancomycin resistance protein
C2H93_RS08330	COG3739	integral membrane protein
C2H93_RS08335	COG0583	DNA-binding transcription factor activity
C2H93_RS08340	COG0697	spore germination
C2H93_RS08350	COG0693	protein deglycase activity
C2H93_RS08355	COG2367	Beta-lactamase
C2H93_RS08380	COG0574	Belongs to the PEP-utilizing enzyme family
C2H93_RS08380	COG3848	Pyruvate phosphate dikinase
C2H93_RS08385	COG0726	polysaccharide deacetylase
C2H93_RS08395	COG2314	TM2 domain
C2H93_RS08400	COG1396	sequence-specific DNA binding
C2H93_RS08440	COG4282	regulation of fungal-type cell wall biogenesis
C2H93_RS08445	COG1231	oxidoreductase activity
C2H93_RS08450	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H93_RS08455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H93_RS08460	COG2207	Transcriptional regulator
C2H93_RS08460	COG0662	Cupin 2, conserved barrel domain protein
C2H93_RS08465	COG0456	acetyltransferase
C2H93_RS08470	COG1309	transcriptional regulator
C2H93_RS08475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS08480	COG3708	Transcriptional regulator
C2H93_RS08485	COG2378	regulation of single-species biofilm formation
C2H93_RS08495	COG0640	Transcriptional regulator
C2H93_RS08500	COG0741	lytic transglycosylase activity
C2H93_RS08505	COG2322	membrane
C2H93_RS08520	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H93_RS08525	COG3239	Fatty acid desaturase
C2H93_RS08530	COG4585	Histidine kinase
C2H93_RS08535	COG2197	response regulator
C2H93_RS08540	COG1388	LysM domain
C2H93_RS08540	COG3584	3D domain protein
C2H93_RS08545	COG0514	ATP-dependent DNA helicase (RecQ)
C2H93_RS08555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H93_RS08560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H93_RS08575	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H93_RS08600	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS08605	COG1657	PFAM Prenyltransferase squalene oxidase
C2H93_RS08610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H93_RS08615	COG0733	neurotransmitter:sodium symporter activity
C2H93_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H93_RS08630	COG0567	Dehydrogenase, E1 component
C2H93_RS08635	COG4548	von Willebrand factor, type A
C2H93_RS08640	COG0714	Associated with various cellular activities
C2H93_RS08645	COG2032	superoxide dismutase activity
C2H93_RS08650	COG0791	NLP P60 protein
C2H93_RS08650	COG1388	LysM domain
C2H93_RS08655	COG1819	glycosyl
C2H93_RS08660	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H93_RS08665	COG0534	Mate efflux family protein
C2H93_RS08670	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS08675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H93_RS08680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H93_RS08690	COG2962	Rard protein
C2H93_RS08705	COG2610	gluconate transmembrane transporter activity
C2H93_RS08710	COG1942	4-Oxalocrotonate Tautomerase
C2H93_RS08715	COG1733	regulation of RNA biosynthetic process
C2H93_RS08720	COG0778	Nitroreductase
C2H93_RS08725	COG0400	carboxylic ester hydrolase activity
C2H93_RS08730	COG0346	lactoylglutathione lyase activity
C2H93_RS08740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H93_RS08745	COG0793	Belongs to the peptidase S41A family
C2H93_RS08745	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS08750	COG2226	methyltransferase
C2H93_RS08760	COG1876	peptidase activity
C2H93_RS08765	COG0813	purine-nucleoside phosphorylase activity
C2H93_RS08780	COG0671	phosphoesterase, PA-phosphatase related
C2H93_RS08800	COG4479	Belongs to the UPF0346 family
C2H93_RS08810	COG1509	lysine 2,3-aminomutase activity
C2H93_RS08815	COG0456	acetyltransferase
C2H93_RS08820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H93_RS08825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H93_RS08830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H93_RS08835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H93_RS08850	COG0456	acetyltransferase
C2H93_RS08855	COG0463	Glycosyl transferase, family 2
C2H93_RS08870	COG4641	Protein conserved in bacteria
C2H93_RS08875	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2H93_RS08880	COG1086	Polysaccharide biosynthesis protein
C2H93_RS08885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H93_RS08890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H93_RS08895	COG1846	Transcriptional regulator
C2H93_RS08900	COG0534	Mate efflux family protein
C2H93_RS08910	COG4698	Protein conserved in bacteria
C2H93_RS08915	COG2755	lipolytic protein G-D-S-L family
C2H93_RS08920	COG1999	signal sequence binding
C2H93_RS08930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H93_RS08935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H93_RS08940	COG1272	protein, Hemolysin III
C2H93_RS08945	COG0204	Acyl-transferase
C2H93_RS08950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H93_RS08955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H93_RS08965	COG2136	Putative SAM-dependent methyltransferase
C2H93_RS08965	COG2521	methyltransferase
C2H93_RS08975	COG0129	dihydroxy-acid dehydratase activity
C2H93_RS08980	COG1413	lyase activity
C2H93_RS08985	COG1418	mRNA catabolic process
C2H93_RS08990	COG0386	Belongs to the glutathione peroxidase family
C2H93_RS08995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H93_RS09000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H93_RS09010	COG1278	Cold shock
C2H93_RS09030	COG0328	RNA-DNA hybrid ribonuclease activity
C2H93_RS09035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H93_RS09040	COG0328	RNA-DNA hybrid ribonuclease activity
C2H93_RS09050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H93_RS09065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H93_RS09075	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2H93_RS09080	COG3424	synthase
C2H93_RS09085	COG2233	PERMEase
C2H93_RS09090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H93_RS09095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H93_RS09105	COG0800	Aldolase
C2H93_RS09110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H93_RS09115	COG1609	Transcriptional regulator
C2H93_RS09120	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H93_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS09130	COG1199	ATP-dependent helicase activity
C2H93_RS09145	COG0116	Belongs to the methyltransferase superfamily
C2H93_RS09160	COG4474	Belongs to the UPF0398 family
C2H93_RS09175	COG3359	exonuclease
C2H93_RS09180	COG1111	helicase
C2H93_RS09180	COG1205	dead DEAH box helicase
C2H93_RS09185	COG2190	(PTS) system
C2H93_RS09190	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H93_RS09225	COG3331	DNA recombination
C2H93_RS09230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H93_RS09230	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H93_RS09240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H93_RS09245	COG3935	DnaD domain protein
C2H93_RS09250	COG0017	Asparaginyl-tRNA synthetase
C2H93_RS09255	COG0436	Aminotransferase
C2H93_RS09260	COG5353	protein conserved in bacteria
C2H93_RS09270	COG1199	ATP-dependent helicase activity
C2H93_RS09270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H93_RS09275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H93_RS09280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H93_RS09285	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2H93_RS09290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H93_RS09290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H93_RS09295	COG0617	tRNA 3'-terminal CCA addition
C2H93_RS09300	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS09305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H93_RS09310	COG1803	Methylglyoxal synthase
C2H93_RS09315	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H93_RS09320	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H93_RS09325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS09335	COG4347	Protein of unknown function (DUF1405)
C2H93_RS09340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H93_RS09340	COG2010	Cytochrome c
C2H93_RS09345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H93_RS09350	COG0723	plastoquinol--plastocyanin reductase activity
C2H93_RS09360	COG5582	Belongs to the UPF0302 family
C2H93_RS09365	COG0457	Tetratricopeptide repeat
C2H93_RS09370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H93_RS09375	COG0287	Prephenate dehydrogenase
C2H93_RS09385	COG0159	tryptophan synthase activity
C2H93_RS09390	COG0133	tryptophan synthase activity
C2H93_RS09395	COG0135	phosphoribosylanthranilate isomerase activity
C2H93_RS09405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H93_RS09410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H93_RS09415	COG4401	Chorismate mutase type I
C2H93_RS09420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H93_RS09425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2H93_RS09430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H93_RS09435	COG0105	UTP biosynthetic process
C2H93_RS09440	COG0142	geranyltranstransferase activity
C2H93_RS09445	COG2226	methyltransferase
C2H93_RS09450	COG0142	geranyltranstransferase activity
C2H93_RS09460	COG0302	gtp cyclohydrolase
C2H93_RS09465	COG0776	regulation of translation
C2H93_RS09470	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H93_RS09485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H93_RS09490	COG1160	GTP binding
C2H93_RS09515	COG1304	FMN binding
C2H93_RS09520	COG0539	negative regulation of cytoplasmic translation
C2H93_RS09525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2H93_RS09535	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H93_RS09540	COG2959	enzyme of heme biosynthesis
C2H93_RS09545	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS09545	COG3773	Cell wall hydrolase
C2H93_RS09550	COG2339	peptidase activity
C2H93_RS09555	COG0492	ferredoxin-NADP+ reductase activity
C2H93_RS09560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H93_RS09565	COG4862	establishment of competence for transformation
C2H93_RS09570	COG1408	metallophosphoesterase
C2H93_RS09580	COG1388	LysM domain
C2H93_RS09585	COG1266	CAAX protease self-immunity
C2H93_RS09590	COG0514	ATP-dependent DNA helicase (RecQ)
C2H93_RS09595	COG4955	Helix-turn-helix domain
C2H93_RS09600	COG1141	Ferredoxin
C2H93_RS09605	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H93_RS09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H93_RS09615	COG0710	3-dehydroquinate dehydratase activity
C2H93_RS09625	COG1595	DNA-templated transcription, initiation
C2H93_RS09630	COG5002	protein histidine kinase activity
C2H93_RS09635	COG0745	RESPONSE REGULATOR receiver
C2H93_RS09640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H93_RS09645	COG1333	cytochrome c biogenesis protein
C2H93_RS09650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS09655	COG1187	pseudouridine synthase activity
C2H93_RS09660	COG0700	Nucleoside recognition
C2H93_RS09665	COG2715	membrane protein required for spore maturation
C2H93_RS09670	COG1686	Belongs to the peptidase S11 family
C2H93_RS09680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H93_RS09685	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H93_RS09690	COG1547	Domain of unknown function (DUF309)
C2H93_RS09695	COG0456	acetyltransferase
C2H93_RS09700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H93_RS09705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H93_RS09705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H93_RS09710	COG0307	riboflavin synthase, alpha
C2H93_RS09715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H93_RS09715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H93_RS09725	COG0681	Belongs to the peptidase S26 family
C2H93_RS09735	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H93_RS09745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H93_RS09750	COG4086	secreted protein
C2H93_RS09755	COG0019	diaminopimelate decarboxylase activity
C2H93_RS09760	COG0697	spore germination
C2H93_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H93_RS09795	COG1191	sigma factor activity
C2H93_RS09800	COG2172	sigma factor antagonist activity
C2H93_RS09805	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS09810	COG1686	Belongs to the peptidase S11 family
C2H93_RS09815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H93_RS09820	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H93_RS09825	COG4974	Belongs to the 'phage' integrase family
C2H93_RS09835	COG0735	belongs to the Fur family
C2H93_RS09840	COG1300	Membrane
C2H93_RS09850	COG0281	malic enzyme
C2H93_RS09855	COG1757	Na H antiporter
C2H93_RS09860	COG1027	Aspartate ammonia-lyase
C2H93_RS09865	COG0252	asparaginase activity
C2H93_RS09870	COG1396	sequence-specific DNA binding
C2H93_RS09875	COG1379	DNA repair
C2H93_RS09880	COG0494	nUDIX hydrolase
C2H93_RS09890	COG0667	Aldo Keto reductase
C2H93_RS09900	COG1073	alpha beta
C2H93_RS09910	COG4918	Iron-sulphur cluster biosynthesis
C2H93_RS09915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H93_RS09915	COG0456	acetyltransferase
C2H93_RS09920	COG2329	Antibiotic biosynthesis monooxygenase
C2H93_RS09925	COG0456	acetyltransferase
C2H93_RS09935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H93_RS09945	COG2211	Major facilitator Superfamily
C2H93_RS09955	COG0346	lactoylglutathione lyase activity
C2H93_RS09960	COG1072	(Pantothenic acid kinase))
C2H93_RS09965	COG3048	D-serine ammonia-lyase activity
C2H93_RS09970	COG0300	oxidoreductase activity
C2H93_RS09975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS09980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H93_RS09985	COG4187	Peptidase family M20/M25/M40
C2H93_RS09990	COG1902	pentaerythritol trinitrate reductase activity
C2H93_RS09995	COG0596	Alpha beta hydrolase
C2H93_RS10005	COG1234	tRNA 3'-trailer cleavage
C2H93_RS10010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H93_RS10015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H93_RS10020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H93_RS10030	COG0706	membrane insertase activity
C2H93_RS10035	COG3361	conserved protein (COG2071)
C2H93_RS10040	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H93_RS10045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H93_RS10050	COG0346	lactoylglutathione lyase activity
C2H93_RS10060	COG1376	ErfK ybiS ycfS ynhG family protein
C2H93_RS10065	COG4129	membrane
C2H93_RS10070	COG1126	abc transporter atp-binding protein
C2H93_RS10075	COG0765	amino acid transport
C2H93_RS10080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H93_RS10090	COG1597	lipid kinase activity
C2H93_RS10095	COG2814	Major facilitator Superfamily
C2H93_RS10100	COG0789	Transcriptional regulator
C2H93_RS10100	COG4978	Transcriptional regulator
C2H93_RS10105	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H93_RS10110	COG0022	dehydrogenase e1 component
C2H93_RS10115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H93_RS10120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H93_RS10125	COG3426	butyrate kinase activity
C2H93_RS10130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H93_RS10135	COG0280	phosphate acetyltransferase
C2H93_RS10140	COG3290	protein histidine kinase activity
C2H93_RS10140	COG3829	transcription factor binding
C2H93_RS10150	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H93_RS10155	COG2079	MmgE PrpD family protein
C2H93_RS10160	COG0372	Belongs to the citrate synthase family
C2H93_RS10165	COG1960	acyl-CoA dehydrogenase activity
C2H93_RS10170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H93_RS10175	COG0183	Belongs to the thiolase family
C2H93_RS10180	COG0584	glycerophosphoryl diester phosphodiesterase
C2H93_RS10185	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS10200	COG1902	pentaerythritol trinitrate reductase activity
C2H93_RS10205	COG0745	RESPONSE REGULATOR receiver
C2H93_RS10210	COG0750	zinc metalloprotease
C2H93_RS10215	COG0497	DNA recombination
C2H93_RS10220	COG1438	arginine binding
C2H93_RS10225	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H93_RS10230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H93_RS10235	COG0142	geranyltranstransferase activity
C2H93_RS10240	COG1722	exodeoxyribonuclease VII activity
C2H93_RS10245	COG1570	exodeoxyribonuclease VII activity
C2H93_RS10250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H93_RS10255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H93_RS10260	COG1302	Protein conserved in bacteria
C2H93_RS10265	COG0439	Biotin carboxylase
C2H93_RS10270	COG0511	ligase activity, forming carbon-carbon bonds
C2H93_RS10310	COG3854	ATPases associated with a variety of cellular activities
C2H93_RS10320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H93_RS10325	COG0006	proline dipeptidase activity
C2H93_RS10330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2H93_RS10340	COG3872	metal-dependent enzyme
C2H93_RS10350	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H93_RS10355	COG1321	iron dependent repressor
C2H93_RS10360	COG0095	Lipoate-protein ligase
C2H93_RS10365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H93_RS10370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H93_RS10375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H93_RS10380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H93_RS10385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H93_RS10400	COG1396	sequence-specific DNA binding
C2H93_RS10410	COG0681	Belongs to the peptidase S26 family
C2H93_RS10435	COG4940	Competence protein ComGF
C2H93_RS10445	COG4970	Tfp pilus assembly protein FimT
C2H93_RS10450	COG4537	Required for transformation and DNA binding
C2H93_RS10455	COG1459	type II secretion system
C2H93_RS10460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H93_RS10465	COG0517	IMP dehydrogenase activity
C2H93_RS10470	COG0598	Magnesium transport protein CorA
C2H93_RS10475	COG1253	flavin adenine dinucleotide binding
C2H93_RS10480	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS10490	COG1393	Belongs to the ArsC family
C2H93_RS10500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS10510	COG0011	TIGRFAM Protein of
C2H93_RS10520	COG2866	Carboxypeptidase
C2H93_RS10525	COG1368	sulfuric ester hydrolase activity
C2H93_RS10530	COG1940	carbohydrate kinase activity
C2H93_RS10535	COG4483	Protein conserved in bacteria
C2H93_RS10540	COG0705	Rhomboid family
C2H93_RS10540	COG0457	Tetratricopeptide repeat
C2H93_RS10550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H93_RS10560	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS10575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H93_RS10580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H93_RS10585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H93_RS10590	COG0581	inorganic phosphate transmembrane transporter activity
C2H93_RS10595	COG0573	inorganic phosphate transmembrane transporter activity
C2H93_RS10600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H93_RS10605	COG0768	penicillin binding
C2H93_RS10610	COG0477	Major facilitator Superfamily
C2H93_RS10615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H93_RS10620	COG2839	Protein conserved in bacteria
C2H93_RS10625	COG5521	maltodextrose utilization protein MalA
C2H93_RS10630	COG1388	LysM domain
C2H93_RS10635	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H93_RS10640	COG4709	membrane
C2H93_RS10645	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H93_RS10650	COG0735	belongs to the Fur family
C2H93_RS10655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS10665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H93_RS10670	COG0513	Belongs to the DEAD box helicase family
C2H93_RS10680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H93_RS10685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H93_RS10690	COG2384	SAM-dependent methyltransferase
C2H93_RS10695	COG2010	Cytochrome c
C2H93_RS10700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H93_RS10705	COG0358	DNA primase activity
C2H93_RS10710	COG1671	Belongs to the UPF0178 family
C2H93_RS10715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H93_RS10720	COG0517	IMP dehydrogenase activity
C2H93_RS10725	COG0751	glycine-tRNA ligase activity
C2H93_RS10730	COG0752	glycyl-tRNA synthetase alpha subunit
C2H93_RS10735	COG1381	Involved in DNA repair and RecF pathway recombination
C2H93_RS10745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H93_RS10750	COG0295	cytidine deaminase activity
C2H93_RS10755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H93_RS10760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2H93_RS10765	COG1480	7TM receptor with intracellular HD hydrolase
C2H93_RS10770	COG1702	phosphate starvation-inducible protein PhoH
C2H93_RS10775	COG0561	phosphatase activity
C2H93_RS10790	COG4864	UPF0365 protein
C2H93_RS10795	COG1030	water channel activity
C2H93_RS10800	COG1610	YqeY-like protein
C2H93_RS10810	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H93_RS10815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H93_RS10820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H93_RS10825	COG2264	protein methyltransferase activity
C2H93_RS10830	COG0484	heat shock protein binding
C2H93_RS10835	COG0443	Heat shock 70 kDa protein
C2H93_RS10840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H93_RS10845	COG1420	regulation of RNA biosynthetic process
C2H93_RS10850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H93_RS10855	COG0481	GTPase activity
C2H93_RS10865	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS10870	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H93_RS10875	COG0268	Binds directly to 16S ribosomal RNA
C2H93_RS10880	COG1466	dna polymerase III delta subunit
C2H93_RS10895	COG0658	competence protein
C2H93_RS10895	COG2333	competence protein COMEC
C2H93_RS10900	COG2131	deaminase
C2H93_RS10905	COG1596	polysaccharide export
C2H93_RS10905	COG1555	photosystem II stabilization
C2H93_RS10910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H93_RS10915	COG2226	methyltransferase
C2H93_RS10920	COG0799	negative regulation of ribosome biogenesis
C2H93_RS10925	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H93_RS10930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H93_RS10935	COG1534	Rna-binding protein
C2H93_RS10940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2H93_RS10945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H93_RS10950	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H93_RS10960	COG2755	lipolytic protein G-D-S-L family
C2H93_RS10965	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS10965	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS10970	COG0398	Pfam SNARE associated Golgi protein
C2H93_RS10975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H93_RS10985	COG3209	COG3209 Rhs family protein
C2H93_RS11010	COG3223	Belongs to the PsiE family
C2H93_RS11015	COG0642	Histidine kinase
C2H93_RS11015	COG5002	protein histidine kinase activity
C2H93_RS11020	COG0745	RESPONSE REGULATOR receiver
C2H93_RS11025	COG2311	Membrane
C2H93_RS11035	COG0454	-acetyltransferase
C2H93_RS11040	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H93_RS11050	COG0730	response to heat
C2H93_RS11055	COG0425	Belongs to the sulfur carrier protein TusA family
C2H93_RS11070	COG0425	Belongs to the sulfur carrier protein TusA family
C2H93_RS11070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H93_RS11075	COG2210	Belongs to the sulfur carrier protein TusA family
C2H93_RS11080	COG1937	Protein conserved in bacteria
C2H93_RS11090	COG0662	Cupin 2, conserved barrel domain protein
C2H93_RS11105	COG0789	Transcriptional regulator
C2H93_RS11105	COG4978	Transcriptional regulator
C2H93_RS11110	COG2814	Major facilitator Superfamily
C2H93_RS11115	COG0456	acetyltransferase
C2H93_RS11120	COG1253	flavin adenine dinucleotide binding
C2H93_RS11130	COG0697	spore germination
C2H93_RS11135	COG0583	DNA-binding transcription factor activity
C2H93_RS11140	COG2072	flavoprotein involved in K transport
C2H93_RS11145	COG1230	cation diffusion facilitator family transporter
C2H93_RS11160	COG1114	Component of the transport system for branched-chain amino acids
C2H93_RS11165	COG1687	branched-chain amino acid
C2H93_RS11170	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H93_RS11175	COG1522	sequence-specific DNA binding
C2H93_RS11180	COG2732	(Barnase) inhibitor
C2H93_RS11190	COG1335	isochorismatase
C2H93_RS11205	COG2318	DinB family
C2H93_RS11215	COG2070	2-Nitropropane dioxygenase
C2H93_RS11220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H93_RS11235	COG1115	amino acid carrier protein
C2H93_RS11270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H93_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS11280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H93_RS11285	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS11290	COG0583	DNA-binding transcription factor activity
C2H93_RS11300	COG2315	Protein conserved in bacteria
C2H93_RS11310	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H93_RS11320	COG2851	Citrate transporter
C2H93_RS11325	COG0583	DNA-binding transcription factor activity
C2H93_RS11330	COG2828	Protein conserved in bacteria
C2H93_RS11335	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS11340	COG5566	PFAM Mor transcription activator
C2H93_RS11345	COG0596	Alpha beta hydrolase
C2H93_RS11350	COG4991	sh3 domain protein
C2H93_RS11355	COG4991	sh3 domain protein
C2H93_RS11365	COG0346	lactoylglutathione lyase activity
C2H93_RS11375	COG5577	PFAM Coat F domain
C2H93_RS11380	COG1063	alcohol dehydrogenase
C2H93_RS11390	COG5577	PFAM Coat F domain
C2H93_RS11395	COG0789	Transcriptional regulator
C2H93_RS11405	COG1064	alcohol dehydrogenase
C2H93_RS11410	COG0693	protein deglycase activity
C2H93_RS11415	COG1621	beta-fructofuranosidase activity
C2H93_RS11425	COG3716	PTS system mannose fructose sorbose family IID component
C2H93_RS11430	COG3715	PTS system
C2H93_RS11435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS11440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS11445	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H93_RS11445	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H93_RS11455	COG1113	amino acid transport
C2H93_RS11460	COG1280	lysine exporter protein (LysE YggA)
C2H93_RS11465	COG1378	Sugar-specific transcriptional regulator TrmB
C2H93_RS11470	COG1595	DNA-templated transcription, initiation
C2H93_RS11480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2H93_RS11480	COG2755	lipolytic protein G-D-S-L family
C2H93_RS11490	COG2124	cytochrome p450
C2H93_RS11490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H93_RS11495	COG1309	transcriptional regulator
C2H93_RS11500	COG2226	methyltransferase
C2H93_RS11515	COG2116	formate transmembrane transporter activity
C2H93_RS11520	COG5609	conserved protein (DUF2294)
C2H93_RS11525	COG3383	formate dehydrogenase (NAD+) activity
C2H93_RS11530	COG2427	Protein of unknown function (DUF1641)
C2H93_RS11540	COG0626	cystathionine gamma-synthase activity
C2H93_RS11545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H93_RS11550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H93_RS11555	COG2226	methyltransferase
C2H93_RS11570	COG0768	penicillin binding
C2H93_RS11575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H93_RS11580	COG0572	uridine kinase
C2H93_RS11585	COG0826	peptidase U32
C2H93_RS11590	COG0826	peptidase U32
C2H93_RS11595	COG4122	O-methyltransferase activity
C2H93_RS11600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H93_RS11605	COG3906	Belongs to the UPF0473 family
C2H93_RS11610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2H93_RS11615	COG4472	Bacterial protein of unknown function (DUF965)
C2H93_RS11620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H93_RS11625	COG0628	permease
C2H93_RS11630	COG1126	abc transporter atp-binding protein
C2H93_RS11635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H93_RS11640	COG0765	amino acid transport
C2H93_RS11645	COG0765	amino acid transport
C2H93_RS11660	COG3881	PFAM PRC-barrel domain
C2H93_RS11665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H93_RS11670	COG0457	Tetratricopeptide repeat
C2H93_RS11675	COG0482	sulfurtransferase activity
C2H93_RS11680	COG1104	cysteine desulfurase activity
C2H93_RS11685	COG1959	2 iron, 2 sulfur cluster binding
C2H93_RS11690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H93_RS11695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H93_RS11705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H93_RS11710	COG0124	histidyl-tRNA synthetase
C2H93_RS11720	COG4991	sh3 domain protein
C2H93_RS11720	COG3103	Sh3 type 3 domain protein
C2H93_RS11720	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS11725	COG1490	D-aminoacyl-tRNA deacylase activity
C2H93_RS11730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H93_RS11735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H93_RS11740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H93_RS11740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H93_RS11745	COG5416	Lipopolysaccharide assembly protein A domain
C2H93_RS11750	COG0490	domain, Protein
C2H93_RS11755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H93_RS11755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H93_RS11765	COG2244	polysaccharide biosynthetic process
C2H93_RS11770	COG2323	membrane
C2H93_RS11780	COG1862	Preprotein translocase
C2H93_RS11785	COG0343	queuine tRNA-ribosyltransferase activity
C2H93_RS11790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H93_RS11800	COG2255	four-way junction helicase activity
C2H93_RS11805	COG0632	four-way junction helicase activity
C2H93_RS11815	COG2814	Major facilitator Superfamily
C2H93_RS11820	COG0673	inositol 2-dehydrogenase activity
C2H93_RS11825	COG2112	serine threonine protein kinase
C2H93_RS11850	COG1115	amino acid carrier protein
C2H93_RS11855	COG0217	transcriptional regulatory protein
C2H93_RS11865	COG1388	LysM domain
C2H93_RS11870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H93_RS11875	COG0157	Belongs to the NadC ModD family
C2H93_RS11880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H93_RS11885	COG1104	cysteine desulfurase activity
C2H93_RS11890	COG1827	regulation of RNA biosynthetic process
C2H93_RS11895	COG0077	Prephenate dehydratase
C2H93_RS11900	COG4492	Belongs to the UPF0735 family
C2H93_RS11905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H93_RS11910	COG3290	protein histidine kinase activity
C2H93_RS11920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H93_RS11925	COG2868	ribosomal protein
C2H93_RS11930	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H93_RS11935	COG1994	Peptidase M50
C2H93_RS11940	COG0739	heme binding
C2H93_RS11945	COG2894	cell division
C2H93_RS11950	COG0850	regulation of cytokinetic process
C2H93_RS11955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H93_RS11965	COG1077	Cell shape determining protein MreB Mrl
C2H93_RS11970	COG2003	Belongs to the UPF0758 family
C2H93_RS11975	COG0424	maF-like protein
C2H93_RS11985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H93_RS11990	COG0285	dihydrofolate synthase activity
C2H93_RS11995	COG0525	valine-tRNA ligase activity
C2H93_RS12005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H93_RS12010	COG1388	LysM domain
C2H93_RS12015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H93_RS12020	COG0113	porphobilinogen synthase activity
C2H93_RS12025	COG1587	Uroporphyrinogen-III synthase
C2H93_RS12030	COG0181	hydroxymethylbilane synthase activity
C2H93_RS12035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H93_RS12040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2H93_RS12050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H93_RS12055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H93_RS12060	COG1067	ATP-dependent peptidase activity
C2H93_RS12060	COG0470	DNA polymerase III
C2H93_RS12065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2H93_RS12070	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H93_RS12075	COG1477	protein flavinylation
C2H93_RS12075	COG0457	Tetratricopeptide repeat
C2H93_RS12080	COG0066	3-isopropylmalate dehydratase activity
C2H93_RS12085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H93_RS12090	COG0473	3-isopropylmalate dehydrogenase activity
C2H93_RS12095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H93_RS12100	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H93_RS12105	COG0440	acetolactate synthase activity
C2H93_RS12110	COG0028	Belongs to the TPP enzyme family
C2H93_RS12120	COG0454	-acetyltransferase
C2H93_RS12125	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H93_RS12140	COG0622	Phosphoesterase
C2H93_RS12145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H93_RS12150	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2H93_RS12155	COG5401	PFAM Sporulation and spore germination
C2H93_RS12160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H93_RS12165	COG1846	Transcriptional regulator
C2H93_RS12170	COG2197	response regulator
C2H93_RS12175	COG0824	Thioesterase
C2H93_RS12180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H93_RS12185	COG1053	succinate dehydrogenase
C2H93_RS12190	COG2009	succinate dehydrogenase
C2H93_RS12195	COG1719	4-vinyl reductase, 4VR
C2H93_RS12200	COG0527	aspartate kinase activity
C2H93_RS12205	COG0322	excinuclease ABC activity
C2H93_RS12210	COG3118	belongs to the thioredoxin family
C2H93_RS12215	COG3534	alpha-L-arabinofuranosidase
C2H93_RS12220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H93_RS12225	COG2086	electron transfer activity
C2H93_RS12230	COG1024	Enoyl-CoA hydratase
C2H93_RS12235	COG1309	transcriptional regulator
C2H93_RS12240	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS12245	COG3766	membrane
C2H93_RS12250	COG1193	negative regulation of DNA recombination
C2H93_RS12255	COG1796	DNA polymerase
C2H93_RS12255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H93_RS12260	COG1286	toxin biosynthetic process
C2H93_RS12265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H93_RS12270	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H93_RS12275	COG0072	phenylalanine-tRNA ligase activity
C2H93_RS12275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H93_RS12280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H93_RS12290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H93_RS12300	COG3835	regulator
C2H93_RS12305	COG0277	FAD linked oxidase domain protein
C2H93_RS12310	COG0247	lactate metabolic process
C2H93_RS12315	COG0346	lactoylglutathione lyase activity
C2H93_RS12325	COG1966	Carbon starvation protein
C2H93_RS12330	COG3534	alpha-L-arabinofuranosidase
C2H93_RS12335	COG0395	ABC-type sugar transport system, permease component
C2H93_RS12340	COG1175	transmembrane transport
C2H93_RS12345	COG1653	transport
C2H93_RS12350	COG0371	Dehydrogenase
C2H93_RS12355	COG0647	UMP catabolic process
C2H93_RS12360	COG0235	Class ii aldolase
C2H93_RS12365	COG1069	ribulokinase activity
C2H93_RS12370	COG2160	L-arabinose isomerase activity
C2H93_RS12375	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H93_RS12380	COG1363	Peptidase, m42
C2H93_RS12390	COG3326	Membrane
C2H93_RS12395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H93_RS12400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2H93_RS12405	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H93_RS12415	COG1346	cytolysis
C2H93_RS12420	COG1380	Effector of murein hydrolase LrgA
C2H93_RS12425	COG3279	Response regulator of the LytR AlgR family
C2H93_RS12430	COG3275	phosphorelay sensor kinase activity
C2H93_RS12435	COG1011	Hydrolase
C2H93_RS12440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H93_RS12450	COG0398	Pfam SNARE associated Golgi protein
C2H93_RS12455	COG1484	DNA-dependent DNA replication
C2H93_RS12460	COG3611	Membrane attachment protein
C2H93_RS12465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H93_RS12470	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H93_RS12475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H93_RS12480	COG1733	regulation of RNA biosynthetic process
C2H93_RS12485	COG2814	Major facilitator Superfamily
C2H93_RS12490	COG0656	L-ascorbic acid biosynthetic process
C2H93_RS12495	COG0237	dephospho-CoA kinase activity
C2H93_RS12500	COG1971	Probably functions as a manganese efflux pump
C2H93_RS12505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H93_RS12510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H93_RS12510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H93_RS12515	COG5002	protein histidine kinase activity
C2H93_RS12520	COG0745	RESPONSE REGULATOR receiver
C2H93_RS12525	COG0039	L-malate dehydrogenase activity
C2H93_RS12530	COG0538	isocitrate dehydrogenase activity
C2H93_RS12535	COG0372	Belongs to the citrate synthase family
C2H93_RS12540	COG2707	UPF0756 membrane protein
C2H93_RS12545	COG0628	permease
C2H93_RS12550	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H93_RS12555	COG0469	pyruvate kinase activity
C2H93_RS12560	COG0205	6-phosphofructokinase activity
C2H93_RS12565	COG0825	malonyl-CoA metabolic process
C2H93_RS12570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H93_RS12575	COG0281	malic enzyme
C2H93_RS12580	COG0587	DNA-directed DNA polymerase activity
C2H93_RS12600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H93_RS12610	COG4109	DRTGG domain
C2H93_RS12615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H93_RS12620	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS12625	COG0165	Argininosuccinate lyase
C2H93_RS12630	COG0137	argininosuccinate synthase activity
C2H93_RS12635	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H93_RS12640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H93_RS12650	COG0827	DNA restriction-modification system
C2H93_RS12655	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H93_RS12660	COG3874	Sporulation protein YtfJ
C2H93_RS12670	COG1714	RDD family
C2H93_RS12675	COG0616	signal peptide processing
C2H93_RS12680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H93_RS12685	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H93_RS12690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H93_RS12700	COG0301	tRNA thio-modification
C2H93_RS12705	COG1104	cysteine desulfurase activity
C2H93_RS12710	COG1114	Component of the transport system for branched-chain amino acids
C2H93_RS12715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H93_RS12720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H93_RS12725	COG1309	transcriptional regulator
C2H93_RS12730	COG1956	GAF domain-containing protein
C2H93_RS12735	COG2203	Gaf domain
C2H93_RS12735	COG2199	diguanylate cyclase activity
C2H93_RS12740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H93_RS12745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H93_RS12750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H93_RS12755	COG0454	-acetyltransferase
C2H93_RS12760	COG0517	IMP dehydrogenase activity
C2H93_RS12765	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2H93_RS12770	COG1360	Flagellar Motor Protein
C2H93_RS12775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H93_RS12780	COG1609	Transcriptional regulator
C2H93_RS12785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H93_RS12785	COG1605	Chorismate mutase
C2H93_RS12790	COG3118	belongs to the thioredoxin family
C2H93_RS12795	COG4980	gas vesicle protein
C2H93_RS12800	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H93_RS12805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H93_RS12810	COG1674	ftsk spoiiie
C2H93_RS12815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H93_RS12820	COG4848	Belongs to the UPF0354 family
C2H93_RS12825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS12840	COG1363	Peptidase, m42
C2H93_RS12845	COG5584	Small secreted protein
C2H93_RS12850	COG0281	malic enzyme
C2H93_RS12855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS12860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H93_RS12870	COG0510	thiamine kinase activity
C2H93_RS12875	COG1523	belongs to the glycosyl hydrolase 13 family
C2H93_RS12880	COG1597	lipid kinase activity
C2H93_RS12890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H93_RS12895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H93_RS12905	COG2252	PERMEase
C2H93_RS12910	COG4473	ABC transporter
C2H93_RS12915	COG1131	(ABC) transporter
C2H93_RS12920	COG1349	DNA-binding transcription factor activity
C2H93_RS12925	COG1187	pseudouridine synthase activity
C2H93_RS12930	COG2244	polysaccharide biosynthetic process
C2H93_RS12935	COG2081	HI0933 family
C2H93_RS12950	COG5578	integral membrane protein
C2H93_RS12955	COG0673	inositol 2-dehydrogenase activity
C2H93_RS12960	COG1653	transport
C2H93_RS12965	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H93_RS12970	COG4209	transmembrane transport
C2H93_RS12975	COG2207	Transcriptional regulator
C2H93_RS12980	COG1653	transport
C2H93_RS12985	COG0395	ABC-type sugar transport system, permease component
C2H93_RS12990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H93_RS12995	COG2124	cytochrome p450
C2H93_RS13000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H93_RS13010	COG0156	8-amino-7-oxononanoate synthase activity
C2H93_RS13015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H93_RS13025	COG1073	alpha beta
C2H93_RS13030	COG1609	Transcriptional regulator
C2H93_RS13035	COG1653	transport
C2H93_RS13040	COG1175	transmembrane transport
C2H93_RS13045	COG0395	ABC-type sugar transport system, permease component
C2H93_RS13050	COG1486	melibiose metabolic process
C2H93_RS13055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H93_RS13060	COG0495	leucyl-tRNA aminoacylation
C2H93_RS13070	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H93_RS13070	COG2202	Pas domain
C2H93_RS13075	COG2814	Major facilitator Superfamily
C2H93_RS13080	COG2433	Pfam Transposase IS66
C2H93_RS13085	COG0577	efflux transmembrane transporter activity
C2H93_RS13090	COG1136	(ABC) transporter
C2H93_RS13095	COG2205	protein histidine kinase activity
C2H93_RS13100	COG0745	RESPONSE REGULATOR receiver
C2H93_RS13105	COG0577	efflux transmembrane transporter activity
C2H93_RS13110	COG1136	(ABC) transporter
C2H93_RS13125	COG1131	(ABC) transporter
C2H93_RS13130	COG1725	Transcriptional regulator
C2H93_RS13145	COG1242	4 iron, 4 sulfur cluster binding
C2H93_RS13150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H93_RS13160	COG2267	carboxylic ester hydrolase activity
C2H93_RS13165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H93_RS13170	COG1113	amino acid transport
C2H93_RS13175	COG0367	asparagine synthase
C2H93_RS13180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H93_RS13185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2H93_RS13195	COG1506	peptidase
C2H93_RS13200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H93_RS13205	COG1116	anion transmembrane transporter activity
C2H93_RS13210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H93_RS13215	COG0494	nUDIX hydrolase
C2H93_RS13220	COG4824	toxin secretion phage lysis holin
C2H93_RS13225	COG0783	Belongs to the Dps family
C2H93_RS13240	COG1854	S-ribosylhomocysteine lyase activity
C2H93_RS13245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H93_RS13250	COG0288	reversible hydration of carbon dioxide
C2H93_RS13255	COG0254	rRNA binding
C2H93_RS13260	COG1271	oxidase subunit
C2H93_RS13265	COG1294	oxidase, subunit
C2H93_RS13275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H93_RS13280	COG1321	iron dependent repressor
C2H93_RS13280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H93_RS13285	COG1121	(ABC) transporter
C2H93_RS13290	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H93_RS13295	COG4948	Mandelate Racemase Muconate Lactonizing
C2H93_RS13300	COG0318	PFAM AMP-dependent synthetase and ligase
C2H93_RS13305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H93_RS13310	COG0596	Alpha beta hydrolase
C2H93_RS13315	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2H93_RS13320	COG1169	isochorismate synthase
C2H93_RS13325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H93_RS13330	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H93_RS13335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H93_RS13340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H93_RS13345	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS13355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H93_RS13360	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS13365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H93_RS13370	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2H93_RS13375	COG0058	SHG alpha-glucan phosphorylase activity
C2H93_RS13380	COG0297	glycogen (starch) synthase activity
C2H93_RS13385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H93_RS13390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H93_RS13395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2H93_RS13520	COG3859	Proton-coupled thiamine transporter YuaJ
C2H93_RS13525	COG1247	-acetyltransferase
C2H93_RS13530	COG2268	Band 7 protein
C2H93_RS13535	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H93_RS13540	COG2318	DinB family
C2H93_RS13550	COG1454	alcohol dehydrogenase
C2H93_RS13555	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS13560	COG1510	regulation of RNA biosynthetic process
C2H93_RS13570	COG0569	domain protein
C2H93_RS13575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H93_RS13580	COG4682	membrane
C2H93_RS13585	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H93_RS13590	COG0477	Major facilitator Superfamily
C2H93_RS13595	COG5553	Cysteine dioxygenase type I
C2H93_RS13605	COG1968	undecaprenyl-diphosphatase activity
C2H93_RS13610	COG0628	permease
C2H93_RS13615	COG0673	inositol 2-dehydrogenase activity
C2H93_RS13620	COG4806	L-rhamnose isomerase
C2H93_RS13625	COG3254	rhamnose metabolic process
C2H93_RS13630	COG1070	Carbohydrate kinase
C2H93_RS13635	COG1349	DNA-binding transcription factor activity
C2H93_RS13640	COG3347	Dehydrogenase
C2H93_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS13645	COG0840	transmembrane signaling receptor activity
C2H93_RS13650	COG0840	transmembrane signaling receptor activity
C2H93_RS13655	COG0840	transmembrane signaling receptor activity
C2H93_RS13660	COG0840	transmembrane signaling receptor activity
C2H93_RS13680	COG0432	Pfam Uncharacterised protein family UPF0047
C2H93_RS13690	COG0366	Alpha amylase catalytic
C2H93_RS13695	COG1253	flavin adenine dinucleotide binding
C2H93_RS13700	COG2738	Putative neutral zinc metallopeptidase
C2H93_RS13715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H93_RS13730	COG0166	Belongs to the GPI family
C2H93_RS13735	COG1979	alcohol dehydrogenase
C2H93_RS13740	COG1979	alcohol dehydrogenase
C2H93_RS13745	COG2155	Conserved Protein
C2H93_RS13750	COG1098	S1 RNA binding domain
C2H93_RS13755	COG0436	Aminotransferase
C2H93_RS13760	COG1522	sequence-specific DNA binding
C2H93_RS13765	COG2267	carboxylic ester hydrolase activity
C2H93_RS13775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H93_RS13780	COG2205	protein histidine kinase activity
C2H93_RS13790	COG5018	Exonuclease
C2H93_RS13800	COG2814	Major facilitator Superfamily
C2H93_RS13805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H93_RS13810	COG3011	Protein conserved in bacteria
C2H93_RS13820	COG3290	protein histidine kinase activity
C2H93_RS13825	COG4565	transcriptional regulatory protein
C2H93_RS13830	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H93_RS13835	COG3845	ABC transporter
C2H93_RS13840	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2H93_RS13845	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2H93_RS13850	COG3493	citrate carrier protein
C2H93_RS13860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H93_RS13860	COG2111	Na H antiporter
C2H93_RS13865	COG2111	Na H antiporter
C2H93_RS13870	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H93_RS13875	COG0651	ATP synthesis coupled electron transport
C2H93_RS13880	COG1863	multisubunit Na H antiporter MnhE subunit
C2H93_RS13885	COG2212	antiporter activity
C2H93_RS13890	COG1320	monovalent cation:proton antiporter activity
C2H93_RS13895	COG2050	protein possibly involved in aromatic compounds catabolism
C2H93_RS13900	COG2197	response regulator
C2H93_RS13905	COG4585	Histidine kinase
C2H93_RS13915	COG0142	geranyltranstransferase activity
C2H93_RS13935	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H93_RS13940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H93_RS13945	COG1335	isochorismatase
C2H93_RS13950	COG5506	Protein of unknown function (DUF1694)
C2H93_RS13965	COG0628	permease
C2H93_RS13980	COG1418	mRNA catabolic process
C2H93_RS13985	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS13995	COG1511	domain protein
C2H93_RS14000	COG1674	ftsk spoiiie
C2H93_RS14000	COG0433	COG0433 Predicted ATPase
C2H93_RS14005	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H93_RS14010	COG5417	Belongs to the EsaB family
C2H93_RS14015	COG4842	Belongs to the WXG100 family
C2H93_RS14020	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H93_RS14020	COG2508	Transcriptional regulator
C2H93_RS14025	COG0686	Belongs to the AlaDH PNT family
C2H93_RS14030	COG5634	Uncharacterized conserved protein (DUF2278)
C2H93_RS14035	COG3251	PFAM MbtH domain protein
C2H93_RS14040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS14045	COG3433	isochorismatase activity
C2H93_RS14045	COG1535	isochorismatase
C2H93_RS14050	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H93_RS14055	COG1169	isochorismate synthase
C2H93_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS14065	COG2819	hydrolase of the alpha beta superfamily
C2H93_RS14070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H93_RS14075	COG1268	BioY protein
C2H93_RS14080	COG2056	Na+-H+ antiporter family
C2H93_RS14085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H93_RS14090	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H93_RS14095	COG3584	3D domain protein
C2H93_RS14110	COG1252	NADH dehydrogenase
C2H93_RS14115	COG0492	ferredoxin-NADP+ reductase activity
C2H93_RS14125	COG0516	GMP reductase activity
C2H93_RS14130	COG2808	Putative FMN-binding domain
C2H93_RS14135	COG0456	acetyltransferase
C2H93_RS14140	COG0316	Belongs to the HesB IscA family
C2H93_RS14145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H93_RS14150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H93_RS14155	COG4844	belongs to the
C2H93_RS14160	COG1252	NADH dehydrogenase
C2H93_RS14165	COG4837	Protein of unknown function (DUF1462)
C2H93_RS14170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H93_RS14175	COG4946	Tricorn protease homolog
C2H93_RS14175	COG1506	peptidase
C2H93_RS14175	COG0823	Involved in the tonB-independent uptake of proteins
C2H93_RS14180	COG0083	homoserine kinase activity
C2H93_RS14185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H93_RS14190	COG0460	homoserine dehydrogenase
C2H93_RS14195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H93_RS14200	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H93_RS14205	COG0647	UMP catabolic process
C2H93_RS14210	COG2445	Protein of unknown function DUF86
C2H93_RS14215	COG4470	Protein conserved in bacteria
C2H93_RS14225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H93_RS14230	COG0739	heme binding
C2H93_RS14240	COG3377	Domain of unknown function (DUF1805)
C2H93_RS14245	COG0737	Belongs to the 5'-nucleotidase family
C2H93_RS14250	COG0730	response to heat
C2H93_RS14255	COG1801	Protein of unknown function DUF72
C2H93_RS14265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H93_RS14270	COG2508	Transcriptional regulator
C2H93_RS14275	COG2233	PERMEase
C2H93_RS14280	COG2233	PERMEase
C2H93_RS14285	COG3648	Uricase
C2H93_RS14285	COG3195	allantoin biosynthetic process
C2H93_RS14290	COG2351	hydroxyisourate hydrolase activity
C2H93_RS14300	COG2080	2 iron, 2 sulfur cluster binding
C2H93_RS14305	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H93_RS14310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H93_RS14315	COG2068	MobA-Related Protein
C2H93_RS14320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H93_RS14325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H93_RS14330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H93_RS14340	COG2356	endonuclease I
C2H93_RS14345	COG3842	ATPase activity
C2H93_RS14350	COG2188	Transcriptional regulator
C2H93_RS14355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H93_RS14360	COG0395	ABC-type sugar transport system, permease component
C2H93_RS14365	COG1175	transmembrane transport
C2H93_RS14370	COG1653	transport
C2H93_RS14375	COG2222	sugar isomerase
C2H93_RS14380	COG0322	excinuclease ABC activity
C2H93_RS14385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H93_RS14400	COG0346	lactoylglutathione lyase activity
C2H93_RS14405	COG0640	Transcriptional regulator
C2H93_RS14410	COG0719	Fe-S assembly protein
C2H93_RS14415	COG0822	iron-sulfur transferase activity
C2H93_RS14420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H93_RS14425	COG0719	Fe-S assembly protein
C2H93_RS14430	COG0396	ATPase activity
C2H93_RS14440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H93_RS14445	COG1464	Belongs to the NlpA lipoprotein family
C2H93_RS14450	COG2011	ABC-type metal ion transport system permease component
C2H93_RS14455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H93_RS14465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H93_RS14470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H93_RS14480	COG0509	glycine decarboxylation via glycine cleavage system
C2H93_RS14485	COG1393	Belongs to the ArsC family
C2H93_RS14490	COG1960	acyl-CoA dehydrogenase activity
C2H93_RS14495	COG0183	Belongs to the thiolase family
C2H93_RS14500	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H93_RS14500	COG1024	Enoyl-CoA hydratase
C2H93_RS14510	COG0506	proline dehydrogenase activity
C2H93_RS14520	COG5577	PFAM Coat F domain
C2H93_RS14525	COG1846	Transcriptional regulator
C2H93_RS14530	COG0477	Major facilitator Superfamily
C2H93_RS14535	COG1942	4-Oxalocrotonate Tautomerase
C2H93_RS14540	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS14545	COG0583	DNA-binding transcription factor activity
C2H93_RS14555	COG1120	ATPase activity
C2H93_RS14570	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS14575	COG0783	Belongs to the Dps family
C2H93_RS14580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H93_RS14585	COG0745	RESPONSE REGULATOR receiver
C2H93_RS14590	COG2770	Histidine kinase
C2H93_RS14590	COG2205	protein histidine kinase activity
C2H93_RS14600	COG1309	transcriptional regulator
C2H93_RS14605	COG0114	fumarate hydratase activity
C2H93_RS14615	COG0697	spore germination
C2H93_RS14620	COG0814	amino acid
C2H93_RS14630	COG2197	response regulator
C2H93_RS14635	COG4585	Histidine kinase
C2H93_RS14640	COG4758	membrane
C2H93_RS14645	COG3595	metallopeptidase activity
C2H93_RS14650	COG1842	Phage shock protein A
C2H93_RS14655	COG4758	membrane
C2H93_RS14660	COG2814	Major facilitator Superfamily
C2H93_RS14665	COG2096	Adenosyltransferase
C2H93_RS14670	COG1120	ATPase activity
C2H93_RS14675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS14680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS14685	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS14690	COG3386	PFAM SMP-30 Gluconolaconase
C2H93_RS14695	COG2205	protein histidine kinase activity
C2H93_RS14700	COG0745	RESPONSE REGULATOR receiver
C2H93_RS14710	COG1191	sigma factor activity
C2H93_RS14720	COG2140	Oxalate decarboxylase
C2H93_RS14730	COG0577	efflux transmembrane transporter activity
C2H93_RS14735	COG1136	(ABC) transporter
C2H93_RS14740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H93_RS14745	COG1120	ATPase activity
C2H93_RS14750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS14755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS14760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS14765	COG0531	amino acid
C2H93_RS14775	COG1988	membrane-bound metal-dependent
C2H93_RS14780	COG1368	sulfuric ester hydrolase activity
C2H93_RS14785	COG1910	domain protein
C2H93_RS14790	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H93_RS14795	COG4149	molybdate abc transporter
C2H93_RS14800	COG0656	L-ascorbic acid biosynthetic process
C2H93_RS14810	COG0025	NhaP-type Na H and K H
C2H93_RS14815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H93_RS14820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H93_RS14825	COG3973	AAA domain
C2H93_RS14835	COG2860	membrane
C2H93_RS14840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H93_RS14845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H93_RS14850	COG2217	Heavy metal translocating P-type atpase
C2H93_RS14855	COG2217	Heavy metal translocating P-type atpase
C2H93_RS14860	COG2608	mercury ion transmembrane transporter activity
C2H93_RS14865	COG1937	Protein conserved in bacteria
C2H93_RS14870	COG0673	inositol 2-dehydrogenase activity
C2H93_RS14875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H93_RS14880	COG1289	transmembrane transporter activity
C2H93_RS14890	COG2076	Multidrug Resistance protein
C2H93_RS14895	COG1309	transcriptional regulator
C2H93_RS14900	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS14920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H93_RS14925	COG0557	exoribonuclease II activity
C2H93_RS14930	COG1647	Serine aminopeptidase, S33
C2H93_RS14935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H93_RS14940	COG0596	Alpha beta hydrolase
C2H93_RS14945	COG1476	TRANSCRIPTIONal
C2H93_RS14950	COG1396	sequence-specific DNA binding
C2H93_RS14955	COG1396	sequence-specific DNA binding
C2H93_RS14960	COG1733	regulation of RNA biosynthetic process
C2H93_RS14965	COG0840	transmembrane signaling receptor activity
C2H93_RS14990	COG1131	(ABC) transporter
C2H93_RS15020	COG1174	glycine betaine transport
C2H93_RS15025	COG1732	Glycine betaine
C2H93_RS15030	COG1174	glycine betaine transport
C2H93_RS15035	COG1125	glycine betaine transport
C2H93_RS15035	COG0517	IMP dehydrogenase activity
C2H93_RS15040	COG1510	regulation of RNA biosynthetic process
C2H93_RS15045	COG1174	glycine betaine transport
C2H93_RS15050	COG1732	Glycine betaine
C2H93_RS15055	COG1174	glycine betaine transport
C2H93_RS15060	COG0517	IMP dehydrogenase activity
C2H93_RS15060	COG1125	glycine betaine transport
C2H93_RS15065	COG1510	regulation of RNA biosynthetic process
C2H93_RS15070	COG2095	MarC family integral membrane protein
C2H93_RS15080	COG3064	Membrane
C2H93_RS15085	COG4640	response to antibiotic
C2H93_RS15090	COG0456	acetyltransferase
C2H93_RS15095	COG0148	phosphopyruvate hydratase activity
C2H93_RS15100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H93_RS15105	COG0149	triose-phosphate isomerase activity
C2H93_RS15110	COG0126	phosphoglycerate kinase activity
C2H93_RS15115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H93_RS15120	COG2390	Transcriptional regulator
C2H93_RS15125	COG2814	Major facilitator Superfamily
C2H93_RS15130	COG1609	Transcriptional regulator
C2H93_RS15135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS15140	COG0583	DNA-binding transcription factor activity
C2H93_RS15145	COG0697	spore germination
C2H93_RS15150	COG1113	amino acid transport
C2H93_RS15155	COG3858	chitin binding
C2H93_RS15160	COG1556	Lactate utilization protein
C2H93_RS15165	COG1139	Iron-sulfur cluster binding protein
C2H93_RS15170	COG0247	lactate metabolic process
C2H93_RS15175	COG2197	response regulator
C2H93_RS15180	COG4585	Histidine kinase
C2H93_RS15185	COG0842	Transport permease protein
C2H93_RS15190	COG1131	(ABC) transporter
C2H93_RS15195	COG0596	Alpha beta hydrolase
C2H93_RS15200	COG2208	phosphoserine phosphatase activity
C2H93_RS15205	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2H93_RS15210	COG1874	Beta-galactosidase
C2H93_RS15215	COG3833	ABC-type maltose transport systems, permease component
C2H93_RS15220	COG1175	transmembrane transport
C2H93_RS15225	COG2182	Extracellular solute-binding protein
C2H93_RS15230	COG1609	Transcriptional regulator
C2H93_RS15235	COG2186	Transcriptional regulator
C2H93_RS15240	COG1620	l-lactate permease
C2H93_RS15245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H93_RS15255	COG5039	Polysaccharide pyruvyl transferase
C2H93_RS15260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H93_RS15265	COG0110	maltose O-acetyltransferase activity
C2H93_RS15270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H93_RS15275	COG2244	polysaccharide biosynthetic process
C2H93_RS15280	COG1216	Glycosyl transferase, family 2
C2H93_RS15285	COG5039	Polysaccharide pyruvyl transferase
C2H93_RS15290	COG1216	Glycosyl transferase, family 2
C2H93_RS15300	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS15305	COG1215	transferase activity, transferring glycosyl groups
C2H93_RS15310	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS15315	COG1086	Polysaccharide biosynthesis protein
C2H93_RS15320	COG0489	protein tyrosine kinase activity
C2H93_RS15325	COG3944	biosynthesis protein
C2H93_RS15330	COG1396	sequence-specific DNA binding
C2H93_RS15335	COG2272	Belongs to the type-B carboxylesterase lipase family
C2H93_RS15345	COG3479	Phenolic acid decarboxylase
C2H93_RS15355	COG1794	racemase activity, acting on amino acids and derivatives
C2H93_RS15360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H93_RS15370	COG1621	beta-fructofuranosidase activity
C2H93_RS15375	COG1621	beta-fructofuranosidase activity
C2H93_RS15380	COG0531	amino acid
C2H93_RS15385	COG1309	transcriptional regulator
C2H93_RS15390	COG2076	Multidrug Resistance protein
C2H93_RS15395	COG2076	Multidrug Resistance protein
C2H93_RS15410	COG0740	serine-type endopeptidase activity
C2H93_RS15415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H93_RS15420	COG0366	Alpha amylase catalytic
C2H93_RS15425	COG1554	hydrolase, family 65, central catalytic
C2H93_RS15430	COG5521	maltodextrose utilization protein MalA
C2H93_RS15435	COG3833	ABC-type maltose transport systems, permease component
C2H93_RS15440	COG1175	transmembrane transport
C2H93_RS15445	COG2182	Extracellular solute-binding protein
C2H93_RS15450	COG0366	Alpha amylase catalytic
C2H93_RS15455	COG1609	Transcriptional regulator
C2H93_RS15460	COG1611	Belongs to the LOG family
C2H93_RS15465	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H93_RS15470	COG0659	secondary active sulfate transmembrane transporter activity
C2H93_RS15475	COG0288	reversible hydration of carbon dioxide
C2H93_RS15480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H93_RS15485	COG0577	efflux transmembrane transporter activity
C2H93_RS15490	COG1136	(ABC) transporter
C2H93_RS15495	COG5002	protein histidine kinase activity
C2H93_RS15500	COG0745	RESPONSE REGULATOR receiver
C2H93_RS15510	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H93_RS15515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS15520	COG1481	regulation of sporulation
C2H93_RS15525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H93_RS15530	COG1660	Displays ATPase and GTPase activities
C2H93_RS15535	COG1051	belongs to the nudix hydrolase family
C2H93_RS15540	COG0492	ferredoxin-NADP+ reductase activity
C2H93_RS15545	COG3883	PFAM NLP P60 protein
C2H93_RS15545	COG0791	NLP P60 protein
C2H93_RS15550	COG0457	Tetratricopeptide repeat
C2H93_RS15555	COG1132	(ABC) transporter
C2H93_RS15575	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H93_RS15575	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H93_RS15580	COG0107	imidazoleglycerol-phosphate synthase activity
C2H93_RS15585	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H93_RS15590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H93_RS15595	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H93_RS15600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H93_RS15605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H93_RS15610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H93_RS15615	COG4990	cell redox homeostasis
C2H93_RS15620	COG5297	Belongs to the glycosyl hydrolase family 6
C2H93_RS15625	COG0110	maltose O-acetyltransferase activity
C2H93_RS15630	COG0546	phosphoglycolate phosphatase activity
C2H93_RS15635	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H93_RS15640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2H93_RS15645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H93_RS15650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H93_RS15655	COG0363	glucosamine-6-phosphate deaminase activity
C2H93_RS15660	COG2188	Transcriptional regulator
C2H93_RS15665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H93_RS15670	COG1846	Transcriptional regulator
C2H93_RS15675	COG2124	cytochrome p450
C2H93_RS15685	COG1846	Transcriptional regulator
C2H93_RS15690	COG2814	Major facilitator Superfamily
C2H93_RS15695	COG1950	PFAM Membrane protein of
C2H93_RS15700	COG1983	PspC domain protein
C2H93_RS15705	COG3595	metallopeptidase activity
C2H93_RS15720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H93_RS15725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H93_RS15730	COG0556	nucleotide-excision repair
C2H93_RS15735	COG4897	Protein conserved in bacteria
C2H93_RS15740	COG3848	Pyruvate phosphate dikinase
C2H93_RS15740	COG0574	Belongs to the PEP-utilizing enzyme family
C2H93_RS15745	COG1309	transcriptional regulator
C2H93_RS15750	COG2814	Major facilitator Superfamily
C2H93_RS15755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H93_RS15765	COG0793	Belongs to the peptidase S41A family
C2H93_RS15765	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS15770	COG2177	Part of the ABC transporter FtsEX involved in
C2H93_RS15775	COG2884	Cell division ATP-binding protein ftsE
C2H93_RS15780	COG2010	Cytochrome c
C2H93_RS15785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS15795	COG0653	protein targeting
C2H93_RS15800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H93_RS15815	COG1516	flagellar protein fliS
C2H93_RS15820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H93_RS15825	COG1334	flagellar protein FlaG
C2H93_RS15830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H93_RS15835	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H93_RS15840	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H93_RS15850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H93_RS15855	COG1256	bacterial-type flagellum assembly
C2H93_RS15855	COG4786	Flagellar basal body rod
C2H93_RS15860	COG3418	PFAM FlgN family protein
C2H93_RS15865	COG2747	anti-sigma28 factor FlgM
C2H93_RS15875	COG1040	competence protein
C2H93_RS15885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H93_RS15890	COG1307	EDD domain protein, DegV family
C2H93_RS15895	COG2197	response regulator
C2H93_RS15900	COG4585	Histidine kinase
C2H93_RS15905	COG1739	Uncharacterized protein family UPF0029
C2H93_RS15910	COG1316	TRANSCRIPTIONal
C2H93_RS15915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H93_RS15920	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS15925	COG1215	transferase activity, transferring glycosyl groups
C2H93_RS15930	COG3206	protein involved in exopolysaccharide biosynthesis
C2H93_RS15935	COG3307	-O-antigen
C2H93_RS15940	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H93_RS15945	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS15945	COG0297	glycogen (starch) synthase activity
C2H93_RS15950	COG2244	polysaccharide biosynthetic process
C2H93_RS15960	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS15960	COG2247	cell wall binding repeat
C2H93_RS15965	COG2385	sporulation resulting in formation of a cellular spore
C2H93_RS15965	COG2247	cell wall binding repeat
C2H93_RS15975	COG1316	TRANSCRIPTIONal
C2H93_RS15980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H93_RS15985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H93_RS15990	COG1134	teichoic acid transport
C2H93_RS15995	COG1682	transport, permease protein
C2H93_RS16000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H93_RS16005	COG0438	transferase activity, transferring glycosyl groups
C2H93_RS16010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2H93_RS16015	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C2H93_RS16020	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H93_RS16030	COG4193	domain, Protein
C2H93_RS16035	COG1482	cell wall glycoprotein biosynthetic process
C2H93_RS16040	COG0697	spore germination
C2H93_RS16045	COG0814	amino acid
C2H93_RS16055	COG2814	Major facilitator Superfamily
C2H93_RS16060	COG1316	TRANSCRIPTIONal
C2H93_RS16065	COG0561	phosphatase activity
C2H93_RS16070	COG0791	NLP P60 protein
C2H93_RS16080	COG2843	Capsule synthesis protein
C2H93_RS16090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H93_RS16095	COG1609	Transcriptional regulator
C2H93_RS16100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H93_RS16105	COG1869	D-ribose catabolic process
C2H93_RS16110	COG1129	ABC transporter
C2H93_RS16115	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H93_RS16120	COG1879	ABC-type sugar transport system periplasmic component
C2H93_RS16125	COG3103	Sh3 type 3 domain protein
C2H93_RS16135	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H93_RS16140	COG3527	Alpha-acetolactate decarboxylase
C2H93_RS16145	COG0028	Belongs to the TPP enzyme family
C2H93_RS16150	COG0583	DNA-binding transcription factor activity
C2H93_RS16155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H93_RS16170	COG5337	Spore coat protein CotH
C2H93_RS16180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H93_RS16190	COG0405	Gamma-glutamyltransferase
C2H93_RS16195	COG1522	sequence-specific DNA binding
C2H93_RS16200	COG2059	Chromate
C2H93_RS16205	COG2059	Chromate
C2H93_RS16215	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H93_RS16220	COG0583	DNA-binding transcription factor activity
C2H93_RS16250	COG5444	nuclease activity
C2H93_RS16270	COG3878	Protein conserved in bacteria
C2H93_RS16275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H93_RS16280	COG4464	protein tyrosine phosphatase activity
C2H93_RS16285	COG0489	protein tyrosine kinase activity
C2H93_RS16290	COG3944	biosynthesis protein
C2H93_RS16300	COG4715	Zinc finger, swim domain protein
C2H93_RS16305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H93_RS16310	COG0561	phosphatase activity
C2H93_RS16315	COG1349	DNA-binding transcription factor activity
C2H93_RS16320	COG0629	single-stranded DNA binding
C2H93_RS16335	COG3764	Sortase (surface protein transpeptidase)
C2H93_RS16345	COG3279	Response regulator of the LytR AlgR family
C2H93_RS16355	COG0745	RESPONSE REGULATOR receiver
C2H93_RS16355	COG2972	Histidine kinase
C2H93_RS16360	COG1970	mechanosensitive ion channel activity
C2H93_RS16365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H93_RS16370	COG0457	Tetratricopeptide repeat
C2H93_RS16375	COG4786	Flagellar basal body rod
C2H93_RS16380	COG4786	Flagellar basal body rod
C2H93_RS16385	COG1077	Cell shape determining protein MreB Mrl
C2H93_RS16390	COG1609	Transcriptional regulator
C2H93_RS16400	COG1846	Transcriptional regulator
C2H93_RS16405	COG2814	Major facilitator Superfamily
C2H93_RS16410	COG3420	alginic acid biosynthetic process
C2H93_RS16415	COG1953	Uracil, thiamine, allantoin
C2H93_RS16420	COG0477	Major facilitator Superfamily
C2H93_RS16425	COG1335	isochorismatase
C2H93_RS16435	COG0004	ammonium transporteR
C2H93_RS16440	COG0347	Belongs to the P(II) protein family
C2H93_RS16445	COG0671	phosphoesterase, PA-phosphatase related
C2H93_RS16455	COG0739	heme binding
C2H93_RS16460	COG1247	-acetyltransferase
C2H93_RS16480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H93_RS16485	COG0789	Transcriptional regulator
C2H93_RS16495	COG2910	NAD(P)H-binding
C2H93_RS16500	COG1959	2 iron, 2 sulfur cluster binding
C2H93_RS16505	COG0804	urea catabolic process
C2H93_RS16510	COG0832	Belongs to the urease beta subunit family
C2H93_RS16515	COG0831	urea catabolic process
C2H93_RS16530	COG3237	CsbD-like
C2H93_RS16535	COG1994	Peptidase M50
C2H93_RS16540	COG0457	Tetratricopeptide repeat
C2H93_RS16545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H93_RS16550	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2H93_RS16560	COG2304	oxidoreductase activity
C2H93_RS16570	COG2304	oxidoreductase activity
C2H93_RS16575	COG2385	sporulation resulting in formation of a cellular spore
C2H93_RS16580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H93_RS16590	COG4836	Membrane
C2H93_RS16600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H93_RS16605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H93_RS16610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H93_RS16615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2H93_RS16620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H93_RS16625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2H93_RS16635	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H93_RS16645	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H93_RS16650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H93_RS16655	COG4475	Protein of unknown function (DUF436)
C2H93_RS16660	COG0698	ribose 5-phosphate isomerase
C2H93_RS16665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H93_RS16670	COG1971	Probably functions as a manganese efflux pump
C2H93_RS16675	COG0009	L-threonylcarbamoyladenylate synthase
C2H93_RS16680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H93_RS16700	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H93_RS16705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H93_RS16710	COG0346	lactoylglutathione lyase activity
C2H93_RS16715	COG0789	Transcriptional regulator
C2H93_RS16720	COG0679	Auxin Efflux Carrier
C2H93_RS16725	COG0281	malic enzyme
C2H93_RS16730	COG1435	thymidine kinase activity
C2H93_RS16740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H93_RS16750	COG1494	fructose-1,6-bisphosphatase
C2H93_RS16755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H93_RS16760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H93_RS16765	COG0191	fructose-bisphosphate aldolase activity
C2H93_RS16770	COG2204	response regulator
C2H93_RS16775	COG4821	SIS domain
C2H93_RS16780	COG0504	CTP synthase activity
C2H93_RS16785	COG3343	RNA polymerase activity
C2H93_RS16790	COG1960	acyl-CoA dehydrogenase activity
C2H93_RS16795	COG0247	lactate metabolic process
C2H93_RS16795	COG2181	nitrate reductase activity
C2H93_RS16800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H93_RS16805	COG4294	response to UV
C2H93_RS16815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H93_RS16820	COG1132	(ABC) transporter
C2H93_RS16825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H93_RS16835	COG2181	nitrate reductase activity
C2H93_RS16840	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H93_RS16845	COG1140	nitrate reductase beta subunit
C2H93_RS16850	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H93_RS16855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H93_RS16865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H93_RS16870	COG2223	nitrite transmembrane transporter activity
C2H93_RS16875	COG0018	arginyl-trna synthetase
C2H93_RS16880	COG4506	Protein conserved in bacteria
C2H93_RS16895	COG0535	radical SAM domain protein
C2H93_RS16905	COG1131	(ABC) transporter
C2H93_RS16910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H93_RS16915	COG0612	Peptidase, M16
C2H93_RS16920	COG0612	Peptidase, M16
C2H93_RS16930	COG3391	amine dehydrogenase activity
C2H93_RS16935	COG3391	amine dehydrogenase activity
C2H93_RS16940	COG0457	Tetratricopeptide repeat
C2H93_RS16950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H93_RS16955	COG0010	Belongs to the arginase family
C2H93_RS16960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H93_RS16965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H93_RS16980	COG1994	Peptidase M50
C2H93_RS16985	COG1942	4-Oxalocrotonate Tautomerase
C2H93_RS16990	COG1846	Transcriptional regulator
C2H93_RS16995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H93_RS17000	COG0477	Major facilitator Superfamily
C2H93_RS17005	COG1959	2 iron, 2 sulfur cluster binding
C2H93_RS17010	COG3465	dGTPase activity
C2H93_RS17015	COG1078	dGTPase activity
C2H93_RS17020	COG4844	belongs to the
C2H93_RS17030	COG0697	spore germination
C2H93_RS17035	COG0095	Lipoate-protein ligase
C2H93_RS17040	COG0583	DNA-binding transcription factor activity
C2H93_RS17045	COG0280	phosphate acetyltransferase
C2H93_RS17050	COG3253	May function as heme-dependent peroxidase
C2H93_RS17055	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS17060	COG0436	Aminotransferase
C2H93_RS17065	COG2814	Major facilitator Superfamily
C2H93_RS17070	COG0151	Belongs to the GarS family
C2H93_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS17080	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS17085	COG0077	Prephenate dehydratase
C2H93_RS17090	COG2814	Major facilitator Superfamily
C2H93_RS17095	COG0833	amino acid
C2H93_RS17100	COG4187	Peptidase family M20/M25/M40
C2H93_RS17105	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS17110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H93_RS17120	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H93_RS17125	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H93_RS17130	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H93_RS17135	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H93_RS17140	COG3980	spore coat polysaccharide biosynthesis protein
C2H93_RS17145	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H93_RS17150	COG2089	acid synthase
C2H93_RS17155	COG0456	acetyltransferase
C2H93_RS17160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H93_RS17165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H93_RS17170	COG0463	Glycosyl transferase, family 2
C2H93_RS17180	COG2363	Small membrane protein
C2H93_RS17185	COG2233	PERMEase
C2H93_RS17195	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS17200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H93_RS17205	COG1216	Glycosyl transferase, family 2
C2H93_RS17220	COG1695	Transcriptional regulator
C2H93_RS17225	COG0351	phosphomethylpyrimidine kinase
C2H93_RS17235	COG1621	beta-fructofuranosidase activity
C2H93_RS17240	COG1263	PTS System
C2H93_RS17240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS17245	COG2116	formate transmembrane transporter activity
C2H93_RS17250	COG3711	transcriptional antiterminator
C2H93_RS17260	COG1404	Belongs to the peptidase S8 family
C2H93_RS17265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS17270	COG0778	Nitroreductase
C2H93_RS17275	COG0772	Belongs to the SEDS family
C2H93_RS17285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H93_RS17290	COG1845	cytochrome c oxidase, subunit III
C2H93_RS17295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H93_RS17300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H93_RS17305	COG2261	transglycosylase associated protein
C2H93_RS17310	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H93_RS17315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H93_RS17320	COG2246	polysaccharide biosynthetic process
C2H93_RS17325	COG1309	transcriptional regulator
C2H93_RS17335	COG3162	membrane
C2H93_RS17340	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H93_RS17345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H93_RS17350	COG2837	iron assimilation
C2H93_RS17355	COG2822	iron ion transport
C2H93_RS17360	COG0672	)-iron permease
C2H93_RS17365	COG0352	thiamine-phosphate diphosphorylase activity
C2H93_RS17370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2H93_RS17375	COG0583	DNA-binding transcription factor activity
C2H93_RS17380	COG1380	Effector of murein hydrolase LrgA
C2H93_RS17385	COG1346	cytolysis
C2H93_RS17390	COG2814	Major facilitator Superfamily
C2H93_RS17395	COG4895	conserved protein (DUF2196)
C2H93_RS17400	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2H93_RS17405	COG0346	lactoylglutathione lyase activity
C2H93_RS17415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H93_RS17420	COG1404	Belongs to the peptidase S8 family
C2H93_RS17425	COG1263	PTS System
C2H93_RS17425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS17430	COG3711	transcriptional antiterminator
C2H93_RS17435	COG1442	glycosyl transferase family 8
C2H93_RS17440	COG5522	Integral membrane protein (intg_mem_TP0381)
C2H93_RS17445	COG1846	Transcriptional regulator
C2H93_RS17450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H93_RS17455	COG2234	aminopeptidase activity
C2H93_RS17460	COG2357	RelA SpoT domain protein
C2H93_RS17465	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H93_RS17480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H93_RS17485	COG1696	Membrane protein involved in D-alanine export
C2H93_RS17490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H93_RS17495	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H93_RS17500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H93_RS17505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H93_RS17510	COG1486	melibiose metabolic process
C2H93_RS17515	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H93_RS17520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H93_RS17525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H93_RS17530	COG3711	transcriptional antiterminator
C2H93_RS17530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H93_RS17540	COG2094	Belongs to the DNA glycosylase MPG family
C2H93_RS17545	COG0753	catalase activity
C2H93_RS17550	COG2814	Major facilitator Superfamily
C2H93_RS17555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H93_RS17560	COG1131	(ABC) transporter
C2H93_RS17580	COG1595	DNA-templated transcription, initiation
C2H93_RS17585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H93_RS17590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H93_RS17595	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H93_RS17600	COG4988	ABC transporter
C2H93_RS17605	COG1294	oxidase, subunit
C2H93_RS17610	COG1271	oxidase subunit
C2H93_RS17615	COG3493	citrate carrier protein
C2H93_RS17620	COG0501	Belongs to the peptidase M48B family
C2H93_RS17630	COG0726	polysaccharide deacetylase
C2H93_RS17635	COG3842	ATPase activity
C2H93_RS17640	COG2508	Transcriptional regulator
C2H93_RS17645	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS17650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H93_RS17660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H93_RS17670	COG4585	Histidine kinase
C2H93_RS17675	COG2197	response regulator
C2H93_RS17680	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H93_RS17690	COG4894	glucomannan catabolic process
C2H93_RS17695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H93_RS17700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H93_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS17710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H93_RS17715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H93_RS17720	COG2610	gluconate transmembrane transporter activity
C2H93_RS17725	COG0500	methyltransferase
C2H93_RS17730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H93_RS17745	COG0753	catalase activity
C2H93_RS17745	COG0693	protein deglycase activity
C2H93_RS17750	COG2851	Citrate transporter
C2H93_RS17755	COG2273	Hydrolase Family 16
C2H93_RS17760	COG3711	transcriptional antiterminator
C2H93_RS17770	COG2270	Major facilitator Superfamily
C2H93_RS17775	COG0513	Belongs to the DEAD box helicase family
C2H93_RS17780	COG2755	lipolytic protein G-D-S-L family
C2H93_RS17780	COG3401	FG-GAP repeat protein
C2H93_RS17810	COG0697	spore germination
C2H93_RS17815	COG0589	response to stress
C2H93_RS17820	COG2723	6-phospho-beta-galactosidase activity
C2H93_RS17825	COG1263	PTS System
C2H93_RS17825	COG2190	(PTS) system
C2H93_RS17825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS17840	COG5444	nuclease activity
C2H93_RS17855	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H93_RS17870	COG2986	histidine ammonia-lyase
C2H93_RS17875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2H93_RS17880	COG1228	amidohydrolase
C2H93_RS17885	COG0010	Belongs to the arginase family
C2H93_RS17890	COG0833	amino acid
C2H93_RS17895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2H93_RS17900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H93_RS17905	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H93_RS17910	COG2390	Transcriptional regulator
C2H93_RS17920	COG3192	ethanolamine utilization protein
C2H93_RS17925	COG2079	MmgE PrpD family protein
C2H93_RS17930	COG1473	amidohydrolase
C2H93_RS17935	COG1126	abc transporter atp-binding protein
C2H93_RS17940	COG0765	amino acid transport
C2H93_RS17945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H93_RS17950	COG0456	acetyltransferase
C2H93_RS17955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS17965	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2H93_RS17970	COG0561	phosphatase activity
C2H93_RS18000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS18005	COG5294	Protein conserved in bacteria
C2H93_RS18010	COG0577	efflux transmembrane transporter activity
C2H93_RS18015	COG1136	(ABC) transporter
C2H93_RS18020	COG2205	protein histidine kinase activity
C2H93_RS18025	COG0745	RESPONSE REGULATOR receiver
C2H93_RS18030	COG0191	fructose-bisphosphate aldolase activity
C2H93_RS18035	COG1082	Xylose isomerase domain protein TIM barrel
C2H93_RS18040	COG1082	Xylose isomerase domain protein TIM barrel
C2H93_RS18045	COG0673	inositol 2-dehydrogenase activity
C2H93_RS18050	COG2814	Major facilitator Superfamily
C2H93_RS18055	COG1082	Xylose isomerase domain protein TIM barrel
C2H93_RS18060	COG3962	Belongs to the TPP enzyme family
C2H93_RS18065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H93_RS18075	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS18080	COG1349	DNA-binding transcription factor activity
C2H93_RS18085	COG0667	Aldo Keto reductase
C2H93_RS18115	COG2814	Major facilitator Superfamily
C2H93_RS18120	COG0326	Molecular chaperone. Has ATPase activity
C2H93_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS18135	COG1309	transcriptional regulator
C2H93_RS18140	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS18145	COG1714	RDD family
C2H93_RS18150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H93_RS18160	COG1714	RDD family
C2H93_RS18165	COG2311	Membrane
C2H93_RS18170	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS18175	COG1309	transcriptional regulator
C2H93_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS18185	COG1846	Transcriptional regulator
C2H93_RS18190	COG1380	Effector of murein hydrolase LrgA
C2H93_RS18195	COG1346	cytolysis
C2H93_RS18200	COG5039	Polysaccharide pyruvyl transferase
C2H93_RS18205	COG1929	Belongs to the glycerate kinase type-1 family
C2H93_RS18210	COG1802	Transcriptional regulator
C2H93_RS18215	COG1070	Carbohydrate kinase
C2H93_RS18220	COG2610	gluconate transmembrane transporter activity
C2H93_RS18225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H93_RS18230	COG0450	alkyl hydroperoxide reductase
C2H93_RS18235	COG3634	alkyl hydroperoxide reductase activity
C2H93_RS18240	COG2723	6-phospho-beta-galactosidase activity
C2H93_RS18245	COG2190	(PTS) system
C2H93_RS18255	COG2188	Transcriptional regulator
C2H93_RS18270	COG1131	(ABC) transporter
C2H93_RS18275	COG1994	Peptidase M50
C2H93_RS18280	COG0535	radical SAM domain protein
C2H93_RS18290	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H93_RS18315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H93_RS18330	COG1063	alcohol dehydrogenase
C2H93_RS18350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H93_RS18355	COG0456	acetyltransferase
C2H93_RS18360	COG0457	Tetratricopeptide repeat
C2H93_RS18370	COG0010	Belongs to the arginase family
C2H93_RS18375	COG0833	amino acid
C2H93_RS18380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H93_RS18385	COG3829	transcription factor binding
C2H93_RS18400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H93_RS18405	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H93_RS18410	COG4853	Protein conserved in bacteria
C2H93_RS18415	COG4863	YycH protein
C2H93_RS18420	COG5002	protein histidine kinase activity
C2H93_RS18425	COG0745	RESPONSE REGULATOR receiver
C2H93_RS18455	COG0346	lactoylglutathione lyase activity
C2H93_RS18460	COG0305	Participates in initiation and elongation during chromosome replication
C2H93_RS18475	COG3093	addiction module antidote protein HigA
C2H93_RS18480	COG2807	transmembrane transport
C2H93_RS18485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H93_RS18490	COG0359	binds to the 23S rRNA
C2H93_RS18495	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H93_RS18500	COG4241	membrane
C2H93_RS18510	COG5577	PFAM Coat F domain
C2H93_RS18515	COG1733	regulation of RNA biosynthetic process
C2H93_RS18520	COG1227	inorganic diphosphatase activity
C2H93_RS18530	COG2271	Major facilitator Superfamily
C2H93_RS18535	COG4978	Transcriptional regulator
C2H93_RS18535	COG0789	Transcriptional regulator
C2H93_RS18545	COG4319	ketosteroid isomerase
C2H93_RS18550	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H93_RS18555	COG2814	Major facilitator Superfamily
C2H93_RS18560	COG0583	DNA-binding transcription factor activity
C2H93_RS18565	COG2153	protein acetylation
C2H93_RS18580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H93_RS18585	COG1846	Transcriptional regulator
C2H93_RS18590	COG2153	protein acetylation
C2H93_RS18595	COG2364	Membrane
C2H93_RS18600	COG0456	acetyltransferase
C2H93_RS18605	COG2315	Protein conserved in bacteria
C2H93_RS18610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H93_RS18630	COG0789	Transcriptional regulator
C2H93_RS18635	COG0697	spore germination
C2H93_RS18645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H93_RS18650	COG0798	PFAM Bile acid sodium symporter
C2H93_RS18655	COG0346	lactoylglutathione lyase activity
C2H93_RS18660	COG0640	Transcriptional regulator
C2H93_RS18685	COG0741	lytic transglycosylase activity
C2H93_RS18685	COG0791	NLP P60 protein
C2H93_RS18690	COG5644	endopeptidase inhibitor activity
C2H93_RS18700	COG0433	COG0433 Predicted ATPase
C2H93_RS18740	COG2946	Replication initiation factor
C2H93_RS18745	COG1674	ftsk spoiiie
C2H93_RS18775	COG1396	sequence-specific DNA binding
C2H93_RS18780	COG2856	Zn peptidase
C2H93_RS18785	COG0457	Tetratricopeptide repeat
C2H93_RS18800	COG5002	protein histidine kinase activity
C2H93_RS18805	COG0745	RESPONSE REGULATOR receiver
C2H93_RS18820	COG1266	CAAX protease self-immunity
C2H93_RS18825	COG0477	Major facilitator Superfamily
C2H93_RS18825	COG2814	Major facilitator Superfamily
C2H93_RS18830	COG0110	maltose O-acetyltransferase activity
C2H93_RS18840	COG1609	Transcriptional regulator
C2H93_RS18845	COG0708	Exodeoxyribonuclease III
C2H93_RS18850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H93_RS18855	COG0629	single-stranded DNA binding
C2H93_RS18860	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H93_RS18865	COG0012	GTP binding
C2H93_RS18870	COG0243	molybdopterin cofactor binding
C2H93_RS18875	COG4481	Protein conserved in bacteria
C2H93_RS18880	COG3949	Membrane
C2H93_RS18890	COG1475	DNA binding
C2H93_RS18895	COG1192	Involved in chromosome partitioning
C2H93_RS18905	COG1475	DNA binding
C2H93_RS18910	COG0357	Ribosomal RNA small subunit methyltransferase G
C2H93_RS18915	COG0445	tRNA wobble uridine modification
C2H93_RS18920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2H93_RS18925	COG1847	R3H domain protein
C2H93_RS18930	COG0706	membrane insertase activity
C2H93_RS18935	COG0594	ribonuclease P activity
C2H93_RS18945	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2H93_RS18950	COG0592	DNA-directed DNA polymerase activity
C2H93_RS18955	COG2501	S4 domain
C2H93_RS18960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H93_RS18970	COG0187	DNA topoisomerase II activity
C2H93_RS18975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H93_RS19010	COG0516	GMP reductase activity
C2H93_RS19010	COG0517	IMP dehydrogenase activity
C2H93_RS19015	COG1686	Belongs to the peptidase S11 family
C2H93_RS19020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2H93_RS19025	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H93_RS19030	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H93_RS19040	COG1428	Deoxynucleoside kinase
C2H93_RS19045	COG1428	Deoxynucleoside kinase
C2H93_RS19050	COG3858	chitin binding
C2H93_RS19050	COG1388	LysM domain
C2H93_RS19055	COG1335	isochorismatase
C2H93_RS19060	COG0590	tRNA wobble adenosine to inosine editing
C2H93_RS19070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H93_RS19075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H93_RS19080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H93_RS19125	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H93_RS19130	COG3853	Toxic anion resistance protein (TelA)
C2H93_RS19135	COG1982	Orn Lys Arg decarboxylase major
C2H93_RS19140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H93_RS19145	COG3870	Protein conserved in bacteria
C2H93_RS19150	COG1728	Protein conserved in bacteria
C2H93_RS19155	COG0470	DNA polymerase III
C2H93_RS19160	COG1774	PSP1 C-terminal conserved region
C2H93_RS19165	COG4467	Involved in initiation control of chromosome replication
C2H93_RS19170	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H93_RS19175	COG2827	Endonuclease containing a URI domain
C2H93_RS19180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H93_RS19185	COG2002	toxin-antitoxin pair type II binding
C2H93_RS19190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H93_RS19190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H93_RS19195	COG0084	hydrolase, TatD family'
C2H93_RS19200	COG3583	domain protein
C2H93_RS19200	COG3584	3D domain protein
C2H93_RS19205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H93_RS19210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H93_RS19220	COG4466	Protein conserved in bacteria
C2H93_RS19230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H93_RS19235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H93_RS19240	COG0251	oxidation-reduction process
C2H93_RS19245	COG2088	sporulation resulting in formation of a cellular spore
C2H93_RS19250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H93_RS19255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H93_RS19260	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H93_RS19265	COG0193	aminoacyl-tRNA hydrolase activity
C2H93_RS19275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H93_RS19280	COG2002	toxin-antitoxin pair type II binding
C2H93_RS19285	COG2244	polysaccharide biosynthetic process
C2H93_RS19290	COG3956	TIGRFAM MazG family protein
C2H93_RS19295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H93_RS19310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H93_RS19315	COG1098	S1 RNA binding domain
C2H93_RS19330	COG2208	phosphoserine phosphatase activity
C2H93_RS19335	COG2304	oxidoreductase activity
C2H93_RS19340	COG0515	serine threonine protein kinase
C2H93_RS19345	COG0037	tRNA processing
C2H93_RS19350	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H93_RS19355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H93_RS19360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H93_RS19365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H93_RS19370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H93_RS19375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H93_RS19380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H93_RS19385	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H93_RS19390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H93_RS19395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H93_RS19400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H93_RS19405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H93_RS19410	COG1396	sequence-specific DNA binding
C2H93_RS19415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H93_RS19420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H93_RS19500	COG4463	regulation of RNA biosynthetic process
C2H93_RS19505	COG3880	PFAM UvrB UvrC protein
C2H93_RS19510	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H93_RS19515	COG0542	response to heat
C2H93_RS19520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H93_RS19525	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2H93_RS19530	COG4956	integral membrane protein (PIN domain superfamily)
C2H93_RS19535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H93_RS19540	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H93_RS19545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H93_RS19550	COG1045	serine acetyltransferase
C2H93_RS19555	COG0215	cysteine-tRNA ligase activity
C2H93_RS19560	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2H93_RS19565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H93_RS19570	COG3688	RNA-binding protein containing a PIN domain
C2H93_RS19575	COG1595	DNA-templated transcription, initiation
C2H93_RS19585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H93_RS19590	COG0250	Participates in transcription elongation, termination and antitermination
C2H93_RS19600	COG0081	regulation of translation
C2H93_RS19605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2H93_RS19615	COG2813	Specifically methylates the guanine in position
C2H93_RS19620	COG0085	RNA polymerase activity
C2H93_RS19625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H93_RS19630	COG1358	cellular component organization or biogenesis
C2H93_RS19635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H93_RS19640	COG0049	tRNA binding
C2H93_RS19645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2H93_RS19650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H93_RS19655	COG0596	Alpha beta hydrolase
C2H93_RS19665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H93_RS19670	COG0088	Forms part of the polypeptide exit tunnel
C2H93_RS19680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H93_RS19695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2H93_RS19700	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H93_RS19710	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H93_RS19715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H93_RS19725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2H93_RS19735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2H93_RS19740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H93_RS19745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H93_RS19750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H93_RS19760	COG0200	Binds to the 23S rRNA
C2H93_RS19765	COG0201	protein transport
C2H93_RS19770	COG0563	adenylate kinase activity
C2H93_RS19775	COG0024	Methionine aminopeptidase
C2H93_RS19780	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2H93_RS19790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H93_RS19795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H93_RS19800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2H93_RS19805	COG0202	RNA polymerase activity
C2H93_RS19810	COG0203	ribosomal protein L17
C2H93_RS19815	COG1122	ATPase activity
C2H93_RS19820	COG1122	ATPase activity
C2H93_RS19825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H93_RS19830	COG0101	tRNA pseudouridine synthase activity
C2H93_RS19835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H93_RS19840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2H93_RS19845	COG2226	methyltransferase
C2H93_RS19855	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H93_RS19860	COG0489	protein tyrosine kinase activity
C2H93_RS19870	COG2194	sulfuric ester hydrolase activity
C2H93_RS19875	COG0726	polysaccharide deacetylase
C2H93_RS19960	COG0659	secondary active sulfate transmembrane transporter activity
C2H93_RS19965	COG0385	Bile acid
C2H93_RS19970	COG2819	hydrolase of the alpha beta superfamily
C2H93_RS19975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS19980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H93_RS19985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS19990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H93_RS19990	COG2207	Transcriptional regulator
C2H93_RS19995	COG3876	Protein conserved in bacteria
C2H93_RS20000	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H93_RS20005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H93_RS20010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS20010	COG1263	PTS System
C2H93_RS20015	COG1737	Transcriptional regulator
C2H93_RS20020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H93_RS20025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H93_RS20030	COG1683	Conserved Protein
C2H93_RS20060	COG1595	DNA-templated transcription, initiation
C2H93_RS20065	COG5662	AntiSigma factor
C2H93_RS20070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H93_RS20075	COG4856	YbbR-like protein
C2H93_RS20080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H93_RS20085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H93_RS20095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H93_RS20100	COG2169	Transcriptional regulator
C2H93_RS20105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H93_RS20110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H93_RS20115	COG3002	Belongs to the UPF0753 family
C2H93_RS20120	COG0288	reversible hydration of carbon dioxide
C2H93_RS20130	COG5609	conserved protein (DUF2294)
C2H93_RS20135	COG0640	Transcriptional regulator
C2H93_RS20140	COG2814	Major facilitator Superfamily
C2H93_RS20170	COG0596	Alpha beta hydrolase
C2H93_RS20175	COG0745	RESPONSE REGULATOR receiver
C2H93_RS20180	COG0642	Histidine kinase
C2H93_RS20190	COG0515	serine threonine protein kinase
C2H93_RS20205	COG1113	amino acid transport
C2H93_RS20220	COG2602	Beta-lactamase
C2H93_RS20225	COG2124	cytochrome p450
C2H93_RS20235	COG0531	amino acid
C2H93_RS20245	COG0584	glycerophosphoryl diester phosphodiesterase
C2H93_RS20250	COG2271	Major facilitator Superfamily
C2H93_RS20260	COG0456	acetyltransferase
C2H93_RS20260	COG1846	Transcriptional regulator
C2H93_RS20265	COG2271	Major facilitator Superfamily
C2H93_RS20275	COG3409	Peptidoglycan-binding domain 1 protein
C2H93_RS20280	COG0697	spore germination
C2H93_RS20285	COG1917	Cupin 2, conserved barrel domain protein
C2H93_RS20285	COG2207	Transcriptional regulator
C2H93_RS20290	COG1397	ADP-ribosylglycohydrolase
C2H93_RS20295	COG5444	nuclease activity
C2H93_RS20300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2H93_RS20305	COG3591	Belongs to the peptidase S1B family
C2H93_RS20315	COG0596	Alpha beta hydrolase
C2H93_RS20320	COG1183	phosphatidylcholine synthase activity
C2H93_RS20325	COG0586	Pfam SNARE associated Golgi protein
C2H93_RS20330	COG0688	phosphatidylethanolamine metabolic process
C2H93_RS20340	COG2312	Erythromycin esterase
C2H93_RS20345	COG1054	Belongs to the UPF0176 family
C2H93_RS20350	COG1301	dicarboxylic acid transport
C2H93_RS20355	COG1263	PTS System
C2H93_RS20355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H93_RS20355	COG2190	(PTS) system
C2H93_RS20360	COG0363	glucosamine-6-phosphate deaminase activity
C2H93_RS20365	COG2188	Transcriptional regulator
C2H93_RS20375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H93_RS20380	COG0833	amino acid
C2H93_RS20385	COG2040	homocysteine
C2H93_RS20390	COG1115	amino acid carrier protein
C2H93_RS20395	COG2066	Belongs to the glutaminase family
C2H93_RS20400	COG4191	Histidine kinase
C2H93_RS20405	COG0784	Response regulator, receiver
C2H93_RS20410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H93_RS20415	COG1012	belongs to the aldehyde dehydrogenase family
C2H93_RS20420	COG2271	Major facilitator Superfamily
C2H93_RS20425	COG4948	Mandelate Racemase Muconate Lactonizing
C2H93_RS20430	COG2186	Transcriptional regulator
C2H93_RS20435	COG2721	sulfolactate sulfo-lyase activity
C2H93_RS20440	COG3173	Aminoglycoside phosphotransferase
C2H93_RS20450	COG0697	spore germination
C2H93_RS20455	COG0745	RESPONSE REGULATOR receiver
C2H93_RS20460	COG2205	protein histidine kinase activity
C2H93_RS20465	COG1131	(ABC) transporter
C2H93_RS20485	COG3773	Cell wall hydrolase
C2H93_RS20500	COG3540	Alkaline phosphatase
C2H93_RS20505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H93_RS20510	COG0805	protein transport
C2H93_RS20515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2H93_RS20520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H93_RS20525	COG0477	Major facilitator Superfamily
C2H93_RS20530	COG1309	transcriptional regulator
C2H93_RS20535	COG0252	asparaginase activity
C2H93_RS20540	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H93_RS20545	COG1714	RDD family
C2H93_RS20550	COG1405	negative regulation of cell septum assembly
C2H93_RS20550	COG3012	SEC-C Motif Domain Protein
C2H93_RS20555	COG3290	protein histidine kinase activity
C2H93_RS20560	COG3279	Response regulator of the LytR AlgR family
C2H93_RS20565	COG4555	ABC transporter
C2H93_RS20570	COG1668	transmembrane transport
C2H93_RS20575	COG0667	Aldo Keto reductase
C2H93_RS20590	COG1595	DNA-templated transcription, initiation
C2H93_RS20595	COG1595	DNA-templated transcription, initiation
C2H93_RS20605	COG0457	Tetratricopeptide repeat
C2H93_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
C2H93_RS20615	COG0366	Alpha amylase catalytic
C2H93_RS20620	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H93_RS20625	COG1121	(ABC) transporter
C2H93_RS20630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H93_RS20635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H93_RS20640	COG2310	stress, protein
C2H93_RS20645	COG2310	stress, protein
C2H93_RS20650	COG2310	stress, protein
C2H93_RS20655	COG0861	Integral membrane protein TerC family
C2H93_RS20665	COG3853	Toxic anion resistance protein (TelA)
C2H93_RS20670	COG0477	Major facilitator Superfamily
C2H93_RS20675	COG2814	Major facilitator Superfamily
C2H93_RS20680	COG0640	Transcriptional regulator
C2H93_RS20685	COG0517	IMP dehydrogenase activity
C2H93_RS20685	COG4175	Glycine betaine
C2H93_RS20690	COG4176	ABC-type proline glycine betaine transport system permease component
C2H93_RS20695	COG2113	Glycine betaine
C2H93_RS20700	COG1473	amidohydrolase
C2H93_RS20705	COG1288	antiporter activity
C2H93_RS20715	COG0366	Alpha amylase catalytic