locus-tag	class	description
U712_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U712_RS00010	COG0592	DNA-directed DNA polymerase activity
U712_RS00015	COG2501	S4 domain
U712_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
U712_RS00030	COG0187	DNA topoisomerase II activity
U712_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U712_RS00070	COG0516	GMP reductase activity
U712_RS00070	COG0517	IMP dehydrogenase activity
U712_RS00075	COG1686	Belongs to the peptidase S11 family
U712_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
U712_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
U712_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
U712_RS00100	COG1428	Deoxynucleoside kinase
U712_RS00105	COG1428	Deoxynucleoside kinase
U712_RS00110	COG3858	chitin binding
U712_RS00110	COG1388	LysM domain
U712_RS00115	COG1335	isochorismatase
U712_RS00120	COG0590	tRNA wobble adenosine to inosine editing
U712_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
U712_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
U712_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
U712_RS00180	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
U712_RS00185	COG3853	Toxic anion resistance protein (TelA)
U712_RS00190	COG1982	Orn Lys Arg decarboxylase major
U712_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U712_RS00200	COG3870	Protein conserved in bacteria
U712_RS00205	COG1728	Protein conserved in bacteria
U712_RS00210	COG0470	DNA polymerase III
U712_RS00215	COG1774	PSP1 C-terminal conserved region
U712_RS00220	COG4467	Involved in initiation control of chromosome replication
U712_RS00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
U712_RS00230	COG2827	Endonuclease containing a URI domain
U712_RS00235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U712_RS00240	COG2002	toxin-antitoxin pair type II binding
U712_RS00245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_RS00245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_RS00250	COG0084	hydrolase, TatD family'
U712_RS00255	COG3584	3D domain protein
U712_RS00255	COG3583	domain protein
U712_RS00260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
U712_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
U712_RS00275	COG4466	Protein conserved in bacteria
U712_RS00285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
U712_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_RS00295	COG0251	oxidation-reduction process
U712_RS00300	COG2088	sporulation resulting in formation of a cellular spore
U712_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U712_RS00310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U712_RS00315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
U712_RS00320	COG0193	aminoacyl-tRNA hydrolase activity
U712_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U712_RS00335	COG2002	toxin-antitoxin pair type II binding
U712_RS00340	COG2244	polysaccharide biosynthetic process
U712_RS00345	COG3956	TIGRFAM MazG family protein
U712_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
U712_RS00365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
U712_RS00370	COG1098	S1 RNA binding domain
U712_RS00385	COG2208	phosphoserine phosphatase activity
U712_RS00390	COG2304	oxidoreductase activity
U712_RS00395	COG0515	serine threonine protein kinase
U712_RS00400	COG0037	tRNA processing
U712_RS00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
U712_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U712_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
U712_RS00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
U712_RS00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U712_RS00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_RS00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U712_RS00440	COG0512	Glutamine amidotransferase of anthranilate synthase
U712_RS00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_RS00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U712_RS00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U712_RS00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
U712_RS00465	COG1396	sequence-specific DNA binding
U712_RS00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U712_RS00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U712_RS00555	COG4463	regulation of RNA biosynthetic process
U712_RS00560	COG3880	PFAM UvrB UvrC protein
U712_RS00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
U712_RS00570	COG0542	response to heat
U712_RS00575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
U712_RS00580	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
U712_RS00585	COG4956	integral membrane protein (PIN domain superfamily)
U712_RS00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U712_RS00595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
U712_RS00600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U712_RS00610	COG1045	serine acetyltransferase
U712_RS00615	COG0215	cysteine-tRNA ligase activity
U712_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
U712_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U712_RS00630	COG3688	RNA-binding protein containing a PIN domain
U712_RS00635	COG1595	DNA-templated transcription, initiation
U712_RS00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U712_RS00645	COG0250	Participates in transcription elongation, termination and antitermination
U712_RS00655	COG0081	regulation of translation
U712_RS00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
U712_RS00670	COG2813	Specifically methylates the guanine in position
U712_RS00675	COG0085	RNA polymerase activity
U712_RS00680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U712_RS00685	COG1358	cellular component organization or biogenesis
U712_RS00690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
U712_RS00695	COG0049	tRNA binding
U712_RS00700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U712_RS00705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U712_RS00710	COG0596	Alpha beta hydrolase
U712_RS00720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U712_RS00725	COG0088	Forms part of the polypeptide exit tunnel
U712_RS00735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U712_RS00750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
U712_RS00755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
U712_RS00765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
U712_RS00770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
U712_RS00780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
U712_RS00790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
U712_RS00795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
U712_RS00800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
U712_RS00805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
U712_RS00815	COG0200	Binds to the 23S rRNA
U712_RS00820	COG0201	protein transport
U712_RS00825	COG0563	adenylate kinase activity
U712_RS00830	COG0024	Methionine aminopeptidase
U712_RS00835	COG2163	COG2163 Ribosomal protein L14E L6E L27E
U712_RS00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
U712_RS00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
U712_RS00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
U712_RS00860	COG0202	RNA polymerase activity
U712_RS00865	COG0203	ribosomal protein L17
U712_RS00870	COG1122	ATPase activity
U712_RS00875	COG1122	ATPase activity
U712_RS00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
U712_RS00885	COG0101	tRNA pseudouridine synthase activity
U712_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
U712_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U712_RS00900	COG2226	methyltransferase
U712_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS00915	COG0489	protein tyrosine kinase activity
U712_RS00925	COG2194	sulfuric ester hydrolase activity
U712_RS00930	COG0726	polysaccharide deacetylase
U712_RS01010	COG0659	secondary active sulfate transmembrane transporter activity
U712_RS01015	COG0385	Bile acid
U712_RS01020	COG2819	hydrolase of the alpha beta superfamily
U712_RS01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS01040	COG2207	Transcriptional regulator
U712_RS01045	COG3876	Protein conserved in bacteria
U712_RS01050	COG1472	Belongs to the glycosyl hydrolase 3 family
U712_RS01055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_RS01060	COG1263	PTS System
U712_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS01065	COG1737	Transcriptional regulator
U712_RS01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
U712_RS01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS01080	COG1683	Conserved Protein
U712_RS01110	COG1595	DNA-templated transcription, initiation
U712_RS01115	COG5662	AntiSigma factor
U712_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
U712_RS01125	COG4856	YbbR-like protein
U712_RS01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U712_RS01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U712_RS01140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
U712_RS01145	COG2169	Transcriptional regulator
U712_RS01150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U712_RS01155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U712_RS01160	COG3002	Belongs to the UPF0753 family
U712_RS01165	COG0288	reversible hydration of carbon dioxide
U712_RS01175	COG5609	conserved protein (DUF2294)
U712_RS01180	COG0640	Transcriptional regulator
U712_RS01185	COG2814	Major facilitator Superfamily
U712_RS01190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U712_RS01200	COG0535	radical SAM domain protein
U712_RS01205	COG1266	CAAX protease self-immunity
U712_RS01210	COG1131	(ABC) transporter
U712_RS01220	COG1413	lyase activity
U712_RS01225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS01230	COG0596	Alpha beta hydrolase
U712_RS01235	COG0745	RESPONSE REGULATOR receiver
U712_RS01240	COG0642	Histidine kinase
U712_RS01250	COG0515	serine threonine protein kinase
U712_RS01265	COG1113	amino acid transport
U712_RS01280	COG2602	Beta-lactamase
U712_RS01285	COG2124	cytochrome p450
U712_RS01295	COG0531	amino acid
U712_RS01300	COG0584	glycerophosphoryl diester phosphodiesterase
U712_RS01305	COG2271	Major facilitator Superfamily
U712_RS01315	COG0456	acetyltransferase
U712_RS01315	COG1846	Transcriptional regulator
U712_RS01320	COG2271	Major facilitator Superfamily
U712_RS01330	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS01335	COG0697	spore germination
U712_RS01340	COG2207	Transcriptional regulator
U712_RS01340	COG1917	Cupin 2, conserved barrel domain protein
U712_RS01345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
U712_RS01350	COG3591	Belongs to the peptidase S1B family
U712_RS01360	COG0596	Alpha beta hydrolase
U712_RS01365	COG1183	phosphatidylcholine synthase activity
U712_RS01370	COG0586	Pfam SNARE associated Golgi protein
U712_RS01375	COG0688	phosphatidylethanolamine metabolic process
U712_RS01385	COG2312	Erythromycin esterase
U712_RS01390	COG2207	Transcriptional regulator
U712_RS01395	COG1054	Belongs to the UPF0176 family
U712_RS01400	COG1301	dicarboxylic acid transport
U712_RS01405	COG2190	(PTS) system
U712_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS01405	COG1263	PTS System
U712_RS01410	COG0363	glucosamine-6-phosphate deaminase activity
U712_RS01415	COG2188	Transcriptional regulator
U712_RS01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_RS01430	COG0833	amino acid
U712_RS01435	COG2040	homocysteine
U712_RS01445	COG1115	amino acid carrier protein
U712_RS01450	COG2066	Belongs to the glutaminase family
U712_RS01455	COG4191	Histidine kinase
U712_RS01460	COG0784	Response regulator, receiver
U712_RS01465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U712_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS01475	COG2271	Major facilitator Superfamily
U712_RS01480	COG4948	Mandelate Racemase Muconate Lactonizing
U712_RS01485	COG2186	Transcriptional regulator
U712_RS01490	COG2721	sulfolactate sulfo-lyase activity
U712_RS01495	COG3173	Aminoglycoside phosphotransferase
U712_RS01505	COG0697	spore germination
U712_RS01510	COG0745	RESPONSE REGULATOR receiver
U712_RS01515	COG2205	protein histidine kinase activity
U712_RS01520	COG1131	(ABC) transporter
U712_RS01535	COG3773	Cell wall hydrolase
U712_RS01540	COG2304	oxidoreductase activity
U712_RS01545	COG3540	Alkaline phosphatase
U712_RS01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_RS01555	COG0805	protein transport
U712_RS01560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
U712_RS01565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U712_RS01570	COG0477	Major facilitator Superfamily
U712_RS01575	COG1309	transcriptional regulator
U712_RS01580	COG0252	asparaginase activity
U712_RS01585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U712_RS01590	COG1714	RDD family
U712_RS01595	COG1405	negative regulation of cell septum assembly
U712_RS01595	COG3012	SEC-C Motif Domain Protein
U712_RS01600	COG3290	protein histidine kinase activity
U712_RS01605	COG3279	Response regulator of the LytR AlgR family
U712_RS01610	COG4555	ABC transporter
U712_RS01615	COG1668	transmembrane transport
U712_RS01620	COG0667	Aldo Keto reductase
U712_RS01630	COG1595	DNA-templated transcription, initiation
U712_RS01635	COG1595	DNA-templated transcription, initiation
U712_RS01640	COG1876	peptidase activity
U712_RS01645	COG0457	Tetratricopeptide repeat
U712_RS01650	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS01655	COG0366	Alpha amylase catalytic
U712_RS01660	COG0803	Belongs to the bacterial solute-binding protein 9 family
U712_RS01665	COG1121	(ABC) transporter
U712_RS01670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_RS01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS01680	COG2310	stress, protein
U712_RS01685	COG2310	stress, protein
U712_RS01690	COG2310	stress, protein
U712_RS01695	COG0861	Integral membrane protein TerC family
U712_RS01705	COG3853	Toxic anion resistance protein (TelA)
U712_RS01710	COG0477	Major facilitator Superfamily
U712_RS01715	COG2814	Major facilitator Superfamily
U712_RS01720	COG0640	Transcriptional regulator
U712_RS01725	COG0517	IMP dehydrogenase activity
U712_RS01725	COG4175	Glycine betaine
U712_RS01730	COG4176	ABC-type proline glycine betaine transport system permease component
U712_RS01735	COG2113	Glycine betaine
U712_RS01740	COG1473	amidohydrolase
U712_RS01745	COG1288	antiporter activity
U712_RS01755	COG0366	Alpha amylase catalytic
U712_RS01760	COG0039	L-malate dehydrogenase activity
U712_RS01765	COG1620	l-lactate permease
U712_RS01770	COG2814	Major facilitator Superfamily
U712_RS01775	COG1846	Transcriptional regulator
U712_RS01780	COG1280	lysine exporter protein (LysE YggA)
U712_RS01785	COG3403	YqcI/YcgG family
U712_RS01790	COG1113	amino acid transport
U712_RS01795	COG3665	Urea carboxylase-associated protein
U712_RS01800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U712_RS01805	COG1660	Displays ATPase and GTPase activities
U712_RS01810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
U712_RS01815	COG2226	methyltransferase
U712_RS01820	COG0583	DNA-binding transcription factor activity
U712_RS01825	COG3458	cephalosporin-C deacetylase activity
U712_RS01830	COG3541	Predicted nucleotidyltransferase
U712_RS01835	COG0506	proline dehydrogenase activity
U712_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS01845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_RS01850	COG2508	Transcriptional regulator
U712_RS01855	COG3689	TIGRFAM TIGR03943 family protein
U712_RS01860	COG0701	Predicted permease
U712_RS01865	COG2267	carboxylic ester hydrolase activity
U712_RS01870	COG0492	ferredoxin-NADP+ reductase activity
U712_RS01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U712_RS01875	COG1587	Uroporphyrinogen-III synthase
U712_RS01880	COG2146	nitrite reductase [NAD(P)H] activity
U712_RS01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_RS01890	COG0243	molybdopterin cofactor binding
U712_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_RS01900	COG2223	nitrite transmembrane transporter activity
U712_RS01905	COG1469	GTP cyclohydrolase I activity
U712_RS01910	COG1376	ErfK ybiS ycfS ynhG family protein
U712_RS01915	COG0523	cobalamin synthesis protein
U712_RS01920	COG0765	amino acid transport
U712_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS01930	COG1714	RDD family
U712_RS01940	COG2723	6-phospho-beta-galactosidase activity
U712_RS01950	COG3209	COG3209 Rhs family protein
U712_RS01955	COG0840	transmembrane signaling receptor activity
U712_RS01955	COG3290	protein histidine kinase activity
U712_RS01960	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U712_RS01965	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
U712_RS01970	COG1733	regulation of RNA biosynthetic process
U712_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS01990	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
U712_RS01995	COG2814	Major facilitator Superfamily
U712_RS02005	COG0697	spore germination
U712_RS02010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS02020	COG2364	Membrane
U712_RS02025	COG1126	abc transporter atp-binding protein
U712_RS02030	COG0765	amino acid transport
U712_RS02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS02040	COG0583	DNA-binding transcription factor activity
U712_RS02045	COG0163	prenyltransferase activity
U712_RS02050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U712_RS02065	COG0596	Alpha beta hydrolase
U712_RS02070	COG3104	oligopeptide transport
U712_RS02075	COG5434	Belongs to the glycosyl hydrolase 28 family
U712_RS02085	COG0697	spore germination
U712_RS02095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
U712_RS02100	COG1136	(ABC) transporter
U712_RS02105	COG0577	efflux transmembrane transporter activity
U712_RS02110	COG0745	RESPONSE REGULATOR receiver
U712_RS02115	COG3850	Histidine kinase
U712_RS02115	COG5002	protein histidine kinase activity
U712_RS02120	COG0457	Tetratricopeptide repeat
U712_RS02140	COG0527	aspartate kinase activity
U712_RS02145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS02150	COG4605	iron ion homeostasis
U712_RS02155	COG4604	ABC transporter, ATP-binding protein
U712_RS02160	COG4607	ABC-type enterochelin transport system periplasmic component
U712_RS02165	COG2814	Major facilitator Superfamily
U712_RS02170	COG1309	transcriptional regulator
U712_RS02175	COG0778	Nitroreductase
U712_RS02180	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
U712_RS02185	COG0640	Transcriptional regulator
U712_RS02190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS02195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
U712_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS02205	COG4975	Glucose uptake
U712_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS02215	COG4549	nuclear export factor GLE1
U712_RS02220	COG2372	response to copper ion
U712_RS02220	COG1276	copper resistance
U712_RS02225	COG1349	DNA-binding transcription factor activity
U712_RS02235	COG2213	PTS system mannitol-specific
U712_RS02240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS02245	COG0246	Mannitol dehydrogenase
U712_RS02250	COG0473	3-isopropylmalate dehydrogenase activity
U712_RS02255	COG0681	Belongs to the peptidase S26 family
U712_RS02260	COG0412	Dienelactone hydrolase
U712_RS02265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U712_RS02270	COG0561	phosphatase activity
U712_RS02275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
U712_RS02280	COG1914	H( )-stimulated, divalent metal cation uptake system
U712_RS02285	COG4336	lyase activity
U712_RS02290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
U712_RS02295	COG1984	allophanate hydrolase subunit 2
U712_RS02300	COG1414	Transcriptional regulator
U712_RS02305	COG2755	lipolytic protein G-D-S-L family
U712_RS02315	COG2329	Antibiotic biosynthesis monooxygenase
U712_RS02320	COG0768	penicillin binding
U712_RS02325	COG4989	oxidoreductase activity
U712_RS02330	COG3711	transcriptional antiterminator
U712_RS02335	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS02340	COG2226	methyltransferase
U712_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS02350	COG1917	Cupin 2, conserved barrel domain protein
U712_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS02360	COG3871	stress protein (general stress protein 26)
U712_RS02370	COG2814	Major facilitator Superfamily
U712_RS02375	COG1914	H( )-stimulated, divalent metal cation uptake system
U712_RS02380	COG2261	transglycosylase associated protein
U712_RS02385	COG4876	unkown
U712_RS02390	COG2217	Heavy metal translocating P-type atpase
U712_RS02395	COG3729	General stress protein
U712_RS02400	COG0662	Cupin 2, conserved barrel domain protein
U712_RS02405	COG2329	Antibiotic biosynthesis monooxygenase
U712_RS02410	COG3546	catalase activity
U712_RS02415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
U712_RS02420	COG3290	protein histidine kinase activity
U712_RS02425	COG4565	transcriptional regulatory protein
U712_RS02430	COG1301	dicarboxylic acid transport
U712_RS02435	COG0628	permease
U712_RS02440	COG1131	(ABC) transporter
U712_RS02445	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_RS02455	COG1960	acyl-CoA dehydrogenase activity
U712_RS02460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_RS02465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS02470	COG1181	Belongs to the D-alanine--D-alanine ligase family
U712_RS02475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U712_RS02480	COG0513	Belongs to the DEAD box helicase family
U712_RS02485	COG3402	PFAM membrane-flanked domain
U712_RS02490	COG3428	Bacterial PH domain
U712_RS02495	COG0705	Rhomboid family
U712_RS02500	COG0736	holo-[acyl-carrier-protein] synthase activity
U712_RS02505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U712_RS02510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U712_RS02515	COG0864	Transcriptional regulator
U712_RS02520	COG2337	Toxic component of a toxin-antitoxin (TA) module
U712_RS02525	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS02530	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS02535	COG2172	sigma factor antagonist activity
U712_RS02540	COG2208	phosphoserine phosphatase activity
U712_RS02545	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS02550	COG2172	sigma factor antagonist activity
U712_RS02555	COG1191	sigma factor activity
U712_RS02560	COG2208	phosphoserine phosphatase activity
U712_RS02565	COG1673	EVE domain
U712_RS02570	COG1846	Transcriptional regulator
U712_RS02575	COG2183	response to ionizing radiation
U712_RS02580	COG3091	SprT-like family
U712_RS02620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS02625	COG1522	sequence-specific DNA binding
U712_RS02630	COG1522	sequence-specific DNA binding
U712_RS02635	COG1335	isochorismatase
U712_RS02640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U712_RS02645	COG2814	Major facilitator Superfamily
U712_RS02665	COG0693	protein deglycase activity
U712_RS02670	COG1278	Cold shock
U712_RS02675	COG1329	Transcriptional regulator
U712_RS02680	COG0697	spore germination
U712_RS02685	COG1917	Cupin 2, conserved barrel domain protein
U712_RS02685	COG2207	Transcriptional regulator
U712_RS02690	COG0697	spore germination
U712_RS02695	COG3708	Transcriptional regulator
U712_RS02695	COG2207	Transcriptional regulator
U712_RS02700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS02705	COG0477	Major facilitator Superfamily
U712_RS02715	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
U712_RS02725	COG0697	spore germination
U712_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS02735	COG2030	dehydratase
U712_RS02740	COG3545	Serine hydrolase
U712_RS02745	COG1733	regulation of RNA biosynthetic process
U712_RS02750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS02755	COG1733	regulation of RNA biosynthetic process
U712_RS02760	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_RS02765	COG2814	Major facilitator Superfamily
U712_RS02770	COG1309	transcriptional regulator
U712_RS02775	COG0640	Transcriptional regulator
U712_RS02780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U712_RS02785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS02790	COG0697	spore germination
U712_RS02795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS02800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
U712_RS02805	COG0640	Transcriptional regulator
U712_RS02810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U712_RS02820	COG4585	Histidine kinase
U712_RS02825	COG2197	response regulator
U712_RS02830	COG2409	Drug exporters of the RND superfamily
U712_RS02835	COG0596	Alpha beta hydrolase
U712_RS02840	COG1811	Na channel or pump
U712_RS02845	COG4978	Transcriptional regulator
U712_RS02845	COG0789	Transcriptional regulator
U712_RS02850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_RS02855	COG0778	Nitroreductase
U712_RS02860	COG0346	lactoylglutathione lyase activity
U712_RS02865	COG2259	Doxx family
U712_RS02870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS02885	COG2323	membrane
U712_RS02890	COG2323	membrane
U712_RS02895	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_RS02910	COG1309	transcriptional regulator
U712_RS02920	COG0456	acetyltransferase
U712_RS02925	COG0488	(ABC) transporter
U712_RS02930	COG1113	amino acid transport
U712_RS02935	COG2318	DinB family
U712_RS02940	COG1846	Transcriptional regulator
U712_RS02945	COG1033	growth of symbiont in host cell
U712_RS02945	COG2409	Drug exporters of the RND superfamily
U712_RS02950	COG0778	Nitroreductase
U712_RS02955	COG1846	Transcriptional regulator
U712_RS02960	COG2814	Major facilitator Superfamily
U712_RS02965	COG0730	response to heat
U712_RS02970	COG1802	Transcriptional regulator
U712_RS02975	COG3858	chitin binding
U712_RS02975	COG1388	LysM domain
U712_RS02980	COG1819	glycosyl
U712_RS02990	COG1785	Belongs to the alkaline phosphatase family
U712_RS02995	COG5646	InterPro IPR014922
U712_RS03005	COG0454	-acetyltransferase
U712_RS03010	COG1078	dGTPase activity
U712_RS03015	COG1388	LysM domain
U712_RS03020	COG2814	Major facilitator Superfamily
U712_RS03025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_RS03030	COG1447	Phosphotransferase system cellobiose-specific component IIA
U712_RS03035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_RS03040	COG2723	6-phospho-beta-galactosidase activity
U712_RS03045	COG2188	Transcriptional regulator
U712_RS03050	COG1940	carbohydrate kinase activity
U712_RS03055	COG1482	cell wall glycoprotein biosynthetic process
U712_RS03060	COG4124	Belongs to the glycosyl hydrolase 26 family
U712_RS03110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
U712_RS03115	COG0802	atpase or kinase
U712_RS03120	COG1214	PFAM Peptidase M22, glycoprotease
U712_RS03125	COG0456	acetyltransferase
U712_RS03130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
U712_RS03135	COG0488	(ABC) transporter
U712_RS03140	COG0315	cyclic pyranopterin monophosphate synthase activity
U712_RS03145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
U712_RS03150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_RS03155	COG0805	protein transport
U712_RS03165	COG1266	CAAX protease self-immunity
U712_RS03175	COG0459	protein refolding
U712_RS03185	COG3378	Phage plasmid primase P4 family
U712_RS03200	COG0270	DNA (cytosine-5-)-methyltransferase activity
U712_RS03205	COG0270	DNA (cytosine-5-)-methyltransferase activity
U712_RS03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U712_RS03225	COG1401	restriction endodeoxyribonuclease activity
U712_RS03240	COG1073	alpha beta
U712_RS03245	COG0457	Tetratricopeptide repeat
U712_RS03250	COG1063	alcohol dehydrogenase
U712_RS03255	COG2211	Major facilitator Superfamily
U712_RS03260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_RS03265	COG1842	Phage shock protein A
U712_RS03270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U712_RS03275	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U712_RS03280	COG4260	virion core protein, lumpy skin disease virus
U712_RS03290	COG2814	Major facilitator Superfamily
U712_RS03295	COG1063	alcohol dehydrogenase
U712_RS03300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U712_RS03305	COG0823	Involved in the tonB-independent uptake of proteins
U712_RS03320	COG2267	carboxylic ester hydrolase activity
U712_RS03330	COG2132	Multicopper oxidase
U712_RS03335	COG1113	amino acid transport
U712_RS03340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_RS03345	COG0714	Associated with various cellular activities
U712_RS03350	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
U712_RS03355	COG1305	Transglutaminase-like
U712_RS03360	COG0519	Catalyzes the synthesis of GMP from XMP
U712_RS03360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U712_RS03365	COG2252	PERMEase
U712_RS03370	COG3064	Membrane
U712_RS03375	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
U712_RS03385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U712_RS03390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U712_RS03395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U712_RS03400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
U712_RS03405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U712_RS03410	COG0047	phosphoribosylformylglycinamidine synthase activity
U712_RS03415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U712_RS03420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
U712_RS03425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
U712_RS03430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
U712_RS03435	COG0138	bifunctional purine biosynthesis protein purh
U712_RS03440	COG0151	Belongs to the GarS family
U712_RS03445	COG1522	sequence-specific DNA binding
U712_RS03450	COG0531	amino acid
U712_RS03460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
U712_RS03465	COG1470	cell adhesion involved in biofilm formation
U712_RS03470	COG4496	protein, YerC YecD
U712_RS03475	COG0069	glutamate synthase activity
U712_RS03480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
U712_RS03485	COG0210	DNA helicase
U712_RS03490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U712_RS03495	COG4851	CamS sex pheromone cAM373 precursor
U712_RS03500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_RS03505	COG1285	pathogenesis
U712_RS03510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_RS03515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U712_RS03520	COG0154	amidase activity
U712_RS03525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U712_RS03530	COG1309	transcriptional regulator
U712_RS03535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U712_RS03540	COG1597	lipid kinase activity
U712_RS03545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U712_RS03550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_RS03555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_RS03560	COG1002	Type II restriction enzyme, methylase subunits
U712_RS03565	COG1061	Type III restriction enzyme res subunit
U712_RS03570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U712_RS03590	COG5444	nuclease activity
U712_RS03595	COG3391	amine dehydrogenase activity
U712_RS03600	COG0457	Tetratricopeptide repeat
U712_RS03610	COG0217	transcriptional regulatory protein
U712_RS03620	COG1309	transcriptional regulator
U712_RS03625	COG3631	Ketosteroid isomerase-related protein
U712_RS03630	COG0702	epimerase
U712_RS03645	COG3546	catalase activity
U712_RS03650	COG0454	-acetyltransferase
U712_RS03660	COG5578	integral membrane protein
U712_RS03665	COG2972	Histidine kinase
U712_RS03670	COG4753	response regulator
U712_RS03670	COG2207	Transcriptional regulator
U712_RS03675	COG1653	transport
U712_RS03680	COG1175	transmembrane transport
U712_RS03685	COG0395	ABC-type sugar transport system, permease component
U712_RS03690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
U712_RS03695	COG2207	Transcriptional regulator
U712_RS03700	COG2755	lipolytic protein G-D-S-L family
U712_RS03710	COG5578	integral membrane protein
U712_RS03715	COG3401	FG-GAP repeat protein
U712_RS03720	COG3401	FG-GAP repeat protein
U712_RS03725	COG2755	lipolytic protein G-D-S-L family
U712_RS03730	COG1874	Beta-galactosidase
U712_RS03740	COG1653	transport
U712_RS03745	COG4209	transmembrane transport
U712_RS03750	COG0395	ABC-type sugar transport system, permease component
U712_RS03755	COG1486	melibiose metabolic process
U712_RS03760	COG2323	membrane
U712_RS03765	COG2329	Antibiotic biosynthesis monooxygenase
U712_RS03770	COG0346	lactoylglutathione lyase activity
U712_RS03785	COG0670	Belongs to the BI1 family
U712_RS03790	COG0697	spore germination
U712_RS03795	COG1846	Transcriptional regulator
U712_RS03800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U712_RS03810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_RS03810	COG2124	cytochrome p450
U712_RS03815	COG1368	sulfuric ester hydrolase activity
U712_RS03820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U712_RS03825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_RS03830	COG1442	glycosyl transferase family 8
U712_RS03835	COG1216	Glycosyl transferase, family 2
U712_RS03840	COG1442	glycosyl transferase family 8
U712_RS03845	COG2223	nitrite transmembrane transporter activity
U712_RS03850	COG1011	Hydrolase
U712_RS03855	COG0531	amino acid
U712_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS03865	COG0840	transmembrane signaling receptor activity
U712_RS03870	COG0488	(ABC) transporter
U712_RS03880	COG0789	Transcriptional regulator
U712_RS03885	COG2814	Major facilitator Superfamily
U712_RS03895	COG0488	(ABC) transporter
U712_RS03900	COG0513	Belongs to the DEAD box helicase family
U712_RS03905	COG0456	acetyltransferase
U712_RS03910	COG2130	NADP-dependent
U712_RS03920	COG2211	Major facilitator Superfamily
U712_RS03925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U712_RS03930	COG1120	ATPase activity
U712_RS03935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS03940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS03945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
U712_RS03960	COG3866	Pectate lyase
U712_RS03965	COG0471	metal ion transport
U712_RS03970	COG3290	protein histidine kinase activity
U712_RS03975	COG4565	transcriptional regulatory protein
U712_RS03980	COG3181	Tripartite tricarboxylate transporter family receptor
U712_RS03985	COG2851	Citrate transporter
U712_RS03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS03995	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
U712_RS04000	COG1254	Belongs to the acylphosphatase family
U712_RS04005	COG2258	MOSC domain
U712_RS04015	COG0024	Methionine aminopeptidase
U712_RS04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS04020	COG1263	PTS System
U712_RS04025	COG1368	sulfuric ester hydrolase activity
U712_RS04035	COG1115	amino acid carrier protein
U712_RS04040	COG0531	amino acid
U712_RS04055	COG0697	spore germination
U712_RS04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS04060	COG1263	PTS System
U712_RS04065	COG0366	Alpha amylase catalytic
U712_RS04070	COG2188	Transcriptional regulator
U712_RS04075	COG0778	Nitroreductase
U712_RS04080	COG0737	Belongs to the 5'-nucleotidase family
U712_RS04085	COG0693	protein deglycase activity
U712_RS04090	COG2814	Major facilitator Superfamily
U712_RS04095	COG4840	Belongs to the UPF0435 family
U712_RS04100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_RS04105	COG4980	gas vesicle protein
U712_RS04110	COG1295	ribonuclease BN
U712_RS04115	COG0477	Major facilitator Superfamily
U712_RS04120	COG0387	Pfam Sodium calcium exchanger
U712_RS04130	COG0668	transmembrane transport
U712_RS04135	COG0535	radical SAM domain protein
U712_RS04145	COG0726	polysaccharide deacetylase
U712_RS04150	COG2084	Dehydrogenase
U712_RS04155	COG0598	Magnesium transport protein CorA
U712_RS04160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
U712_RS04165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U712_RS04175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U712_RS04180	COG4637	Psort location Cytoplasmic, score
U712_RS04190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_RS04195	COG0022	dehydrogenase e1 component
U712_RS04200	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_RS04205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_RS04210	COG3284	Transcriptional regulator
U712_RS04220	COG1742	UPF0060 membrane protein
U712_RS04245	COG4842	Belongs to the WXG100 family
U712_RS04250	COG1486	melibiose metabolic process
U712_RS04255	COG1737	Transcriptional regulator
U712_RS04260	COG1263	PTS System
U712_RS04260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS04265	COG1132	(ABC) transporter
U712_RS04270	COG1132	(ABC) transporter
U712_RS04275	COG2259	Doxx family
U712_RS04280	COG2514	catechol 2,3-dioxygenase activity
U712_RS04285	COG1917	Cupin 2, conserved barrel domain protein
U712_RS04285	COG4977	sequence-specific DNA binding
U712_RS04290	COG2814	Major facilitator Superfamily
U712_RS04295	COG1082	Xylose isomerase domain protein TIM barrel
U712_RS04300	COG0673	inositol 2-dehydrogenase activity
U712_RS04305	COG4585	Histidine kinase
U712_RS04310	COG2197	response regulator
U712_RS04315	COG1131	(ABC) transporter
U712_RS04320	COG1511	domain protein
U712_RS04320	COG0842	Transport permease protein
U712_RS04325	COG0842	Transport permease protein
U712_RS04330	COG1695	Transcriptional regulator
U712_RS04335	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U712_RS04340	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
U712_RS04345	COG1309	transcriptional regulator
U712_RS04350	COG2814	Major facilitator Superfamily
U712_RS04355	COG2318	DinB family
U712_RS04360	COG2814	Major facilitator Superfamily
U712_RS04365	COG1846	Transcriptional regulator
U712_RS04370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
U712_RS04370	COG0392	lysyltransferase activity
U712_RS04375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS04380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS04385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS04390	COG0384	phenazine biosynthesis protein PhzF
U712_RS04395	COG0778	Nitroreductase
U712_RS04405	COG1090	epimerase
U712_RS04410	COG2137	regulation of response to DNA damage stimulus
U712_RS04420	COG2814	Major facilitator Superfamily
U712_RS04435	COG3103	Sh3 type 3 domain protein
U712_RS04440	COG5658	integral membrane protein
U712_RS04445	COG0596	Alpha beta hydrolase
U712_RS04450	COG0463	Glycosyl transferase, family 2
U712_RS04455	COG4485	Bacterial membrane protein, YfhO
U712_RS04460	COG1988	membrane-bound metal-dependent
U712_RS04465	COG1194	a g-specific adenine glycosylase
U712_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS04490	COG3557	Belongs to the UPF0374 family
U712_RS04495	COG1132	(ABC) transporter
U712_RS04500	COG4129	membrane
U712_RS04505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U712_RS04510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U712_RS04515	COG0735	belongs to the Fur family
U712_RS04625	COG4326	sporulation control protein
U712_RS04635	COG3340	Belongs to the peptidase S51 family
U712_RS04640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
U712_RS04645	COG0277	FAD linked oxidase domain protein
U712_RS04655	COG0753	catalase activity
U712_RS04660	COG1116	anion transmembrane transporter activity
U712_RS04665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U712_RS04670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U712_RS04675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS04685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
U712_RS04695	COG1476	TRANSCRIPTIONal
U712_RS04705	COG3382	B3 4 domain protein
U712_RS04710	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
U712_RS04720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U712_RS04725	COG0789	Transcriptional regulator
U712_RS04730	COG1664	Polymer-forming cytoskeletal
U712_RS04735	COG1664	Polymer-forming cytoskeletal
U712_RS04740	COG2766	serine protein kinase
U712_RS04745	COG2718	Belongs to the UPF0229 family
U712_RS04750	COG1846	Transcriptional regulator
U712_RS04755	COG1566	PFAM secretion protein HlyD family protein
U712_RS04760	COG2814	Major facilitator Superfamily
U712_RS04765	COG0655	NAD(P)H dehydrogenase (quinone) activity
U712_RS04780	COG1725	Transcriptional regulator
U712_RS04785	COG1131	(ABC) transporter
U712_RS04790	COG1131	(ABC) transporter
U712_RS04795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_RS04800	COG1278	Cold shock
U712_RS04810	COG1464	Belongs to the NlpA lipoprotein family
U712_RS04815	COG3706	GGDEF domain
U712_RS04820	COG1823	symporter activity
U712_RS04840	COG5577	PFAM Coat F domain
U712_RS04845	COG0737	Belongs to the 5'-nucleotidase family
U712_RS04845	COG1525	nuclease
U712_RS04845	COG4085	toxin activity
U712_RS04850	COG3764	Sortase (surface protein transpeptidase)
U712_RS04855	COG0564	pseudouridine synthase activity
U712_RS04865	COG0517	IMP dehydrogenase activity
U712_RS04870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U712_RS04875	COG3153	acetyltransferase
U712_RS04875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U712_RS04880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_RS04885	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
U712_RS04890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U712_RS04895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
U712_RS04900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U712_RS04905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U712_RS04910	COG4585	Histidine kinase
U712_RS04910	COG2203	Gaf domain
U712_RS04915	COG2197	response regulator
U712_RS04920	COG0431	NADPH-dependent FMN reductase
U712_RS04935	COG1388	LysM domain
U712_RS04935	COG0791	NLP P60 protein
U712_RS04940	COG1959	2 iron, 2 sulfur cluster binding
U712_RS04945	COG0668	transmembrane transport
U712_RS04950	COG2719	SpoVR family
U712_RS04955	COG1785	Belongs to the alkaline phosphatase family
U712_RS04960	COG0791	NLP P60 protein
U712_RS04960	COG1388	LysM domain
U712_RS04965	COG0583	DNA-binding transcription factor activity
U712_RS04970	COG0372	Belongs to the citrate synthase family
U712_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS04980	COG0531	amino acid
U712_RS04985	COG0733	neurotransmitter:sodium symporter activity
U712_RS04990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS04995	COG0456	acetyltransferase
U712_RS05010	COG1595	DNA-templated transcription, initiation
U712_RS05015	COG0667	Aldo Keto reductase
U712_RS05020	COG0204	Acyl-transferase
U712_RS05025	COG1253	flavin adenine dinucleotide binding
U712_RS05030	COG0789	Transcriptional regulator
U712_RS05035	COG0436	Aminotransferase
U712_RS05040	COG1253	flavin adenine dinucleotide binding
U712_RS05045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U712_RS05050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U712_RS05055	COG0584	glycerophosphoryl diester phosphodiesterase
U712_RS05060	COG0668	transmembrane transport
U712_RS05065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U712_RS05070	COG0726	polysaccharide deacetylase
U712_RS05075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_RS05080	COG1757	Na H antiporter
U712_RS05085	COG0589	response to stress
U712_RS05090	COG1132	(ABC) transporter
U712_RS05095	COG1132	(ABC) transporter
U712_RS05100	COG0702	epimerase
U712_RS05115	COG0189	ligase activity
U712_RS05120	COG0189	ligase activity
U712_RS05125	COG4399	Belongs to the UPF0754 family
U712_RS05130	COG3679	Belongs to the UPF0342 family
U712_RS05135	COG4335	DNA alkylation repair
U712_RS05140	COG0561	phosphatase activity
U712_RS05145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U712_RS05150	COG0475	glutathione-regulated potassium exporter activity
U712_RS05155	COG0490	domain, Protein
U712_RS05165	COG1024	Enoyl-CoA hydratase
U712_RS05175	COG4152	abc transporter atp-binding protein
U712_RS05180	COG1668	transmembrane transport
U712_RS05185	COG0420	3'-5' exonuclease activity
U712_RS05190	COG4717	serine-type aminopeptidase activity
U712_RS05195	COG3481	metal-dependent phosphohydrolase, HD sub domain
U712_RS05205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U712_RS05230	COG1846	Transcriptional regulator
U712_RS05235	COG4980	gas vesicle protein
U712_RS05250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U712_RS05255	COG0537	adenosine 5'-monophosphoramidase activity
U712_RS05260	COG1131	(ABC) transporter
U712_RS05265	COG4473	ABC transporter
U712_RS05275	COG1473	amidohydrolase
U712_RS05280	COG3069	C4-dicarboxylate transmembrane transporter activity
U712_RS05290	COG2329	Antibiotic biosynthesis monooxygenase
U712_RS05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_RS05300	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
U712_RS05305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
U712_RS05310	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
U712_RS05315	COG1309	transcriptional regulator
U712_RS05320	COG1511	domain protein
U712_RS05325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_RS05330	COG4377	Putative membrane peptidase family (DUF2324)
U712_RS05340	COG1363	Peptidase, m42
U712_RS05345	COG4405	Protein conserved in bacteria
U712_RS05350	COG1301	dicarboxylic acid transport
U712_RS05355	COG1234	tRNA 3'-trailer cleavage
U712_RS05360	COG0095	Lipoate-protein ligase
U712_RS05365	COG0702	epimerase
U712_RS05370	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS05380	COG0501	Belongs to the peptidase M48B family
U712_RS05385	COG1404	Belongs to the peptidase S8 family
U712_RS05390	COG0456	acetyltransferase
U712_RS05395	COG0604	alcohol dehydrogenase
U712_RS05400	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
U712_RS05405	COG0406	alpha-ribazole phosphatase activity
U712_RS05410	COG0183	Belongs to the thiolase family
U712_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS05420	COG1268	BioY protein
U712_RS05425	COG0840	transmembrane signaling receptor activity
U712_RS05430	COG0723	plastoquinol--plastocyanin reductase activity
U712_RS05430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_RS05435	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS05445	COG4903	ComK protein
U712_RS05450	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS05460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_RS05475	COG0398	Pfam SNARE associated Golgi protein
U712_RS05480	COG0681	Belongs to the peptidase S26 family
U712_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U712_RS05490	COG1846	Transcriptional regulator
U712_RS05495	COG0738	Major facilitator superfamily
U712_RS05500	COG0673	inositol 2-dehydrogenase activity
U712_RS05505	COG0561	phosphatase activity
U712_RS05510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_RS05515	COG1609	Transcriptional regulator
U712_RS05520	COG3180	Ammonia monooxygenase
U712_RS05525	COG0477	Major facilitator Superfamily
U712_RS05525	COG2814	Major facilitator Superfamily
U712_RS05530	COG4533	DNA binding
U712_RS05540	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
U712_RS05545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
U712_RS05550	COG1074	ATP-dependent DNA helicase activity
U712_RS05555	COG0420	3'-5' exonuclease activity
U712_RS05560	COG0419	ATPase involved in DNA repair
U712_RS05565	COG1403	HNH endonuclease
U712_RS05605	COG5337	Spore coat protein CotH
U712_RS05610	COG0179	Fumarylacetoacetate (FAA) hydrolase
U712_RS05620	COG1404	Belongs to the peptidase S8 family
U712_RS05630	COG0367	asparagine synthase
U712_RS05635	COG2318	DinB family
U712_RS05640	COG1562	ergosterol biosynthetic process
U712_RS05645	COG0534	Mate efflux family protein
U712_RS05650	COG1917	Cupin 2, conserved barrel domain protein
U712_RS05650	COG2207	Transcriptional regulator
U712_RS05655	COG1609	Transcriptional regulator
U712_RS05660	COG0673	inositol 2-dehydrogenase activity
U712_RS05665	COG2318	DinB family
U712_RS05670	COG1279	arginine transmembrane transporter activity
U712_RS05675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_RS05680	COG1357	PFAM Pentapeptide repeats (8 copies)
U712_RS05685	COG2267	carboxylic ester hydrolase activity
U712_RS05690	COG0529	Catalyzes the synthesis of activated sulfate
U712_RS05695	COG2046	Belongs to the sulfate adenylyltransferase family
U712_RS05700	COG0175	sulfate reduction
U712_RS05705	COG2045	Belongs to the ComB family
U712_RS05710	COG1809	phosphosulfolactate synthase activity
U712_RS05715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS05720	COG4948	Mandelate Racemase Muconate Lactonizing
U712_RS05725	COG2814	Major facilitator Superfamily
U712_RS05730	COG0454	-acetyltransferase
U712_RS05735	COG2153	protein acetylation
U712_RS05740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
U712_RS05740	COG0646	methionine synthase
U712_RS05745	COG1666	GTP binding
U712_RS05750	COG2996	Protein conserved in bacteria
U712_RS05770	COG1695	Transcriptional regulator
U712_RS05785	COG3227	Zinc metalloprotease (Elastase)
U712_RS05790	COG1307	EDD domain protein, DegV family
U712_RS05795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS05810	COG0561	phosphatase activity
U712_RS05815	COG1073	alpha beta
U712_RS05820	COG2151	metal-sulfur cluster biosynthetic enzyme
U712_RS05825	COG0277	FAD linked oxidase domain protein
U712_RS05830	COG2271	Major facilitator Superfamily
U712_RS05835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U712_RS05840	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
U712_RS05850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U712_RS05855	COG0505	Belongs to the CarA family
U712_RS05860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U712_RS05865	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U712_RS05880	COG2267	carboxylic ester hydrolase activity
U712_RS05890	COG1744	ABC transporter substrate-binding protein PnrA-like
U712_RS05905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_RS05910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U712_RS05915	COG5504	Zn-dependent protease
U712_RS05920	COG0444	Belongs to the ABC transporter superfamily
U712_RS05925	COG4608	Belongs to the ABC transporter superfamily
U712_RS05935	COG0601	transmembrane transport
U712_RS05940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_RS05950	COG0180	Tryptophanyl-tRNA synthetase
U712_RS05955	COG4166	transmembrane transport
U712_RS05960	COG0601	transmembrane transport
U712_RS05965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_RS05970	COG0444	Belongs to the ABC transporter superfamily
U712_RS05975	COG4608	Belongs to the ABC transporter superfamily
U712_RS05980	COG2814	Major facilitator Superfamily
U712_RS05985	COG0456	acetyltransferase
U712_RS05990	COG1393	Belongs to the ArsC family
U712_RS05995	COG0861	Integral membrane protein TerC family
U712_RS06000	COG4862	establishment of competence for transformation
U712_RS06005	COG4469	Competence protein
U712_RS06010	COG1164	Oligoendopeptidase f
U712_RS06020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
U712_RS06025	COG2346	COG2346, Truncated hemoglobins
U712_RS06030	COG0741	lytic transglycosylase activity
U712_RS06035	COG4116	CYTH
U712_RS06045	COG2357	RelA SpoT domain protein
U712_RS06050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U712_RS06055	COG0564	pseudouridine synthase activity
U712_RS06060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U712_RS06065	COG0569	domain protein
U712_RS06065	COG0475	glutathione-regulated potassium exporter activity
U712_RS06070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
U712_RS06075	COG0352	thiamine-phosphate diphosphorylase activity
U712_RS06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_RS06085	COG2104	thiamine diphosphate biosynthetic process
U712_RS06090	COG2022	thiamine diphosphate biosynthetic process
U712_RS06095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U712_RS06100	COG0351	phosphomethylpyrimidine kinase
U712_RS06105	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U712_RS06160	COG0210	DNA helicase
U712_RS06170	COG2153	protein acetylation
U712_RS06175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U712_RS06180	COG2382	esterase
U712_RS06185	COG0626	cystathionine gamma-synthase activity
U712_RS06190	COG0626	cystathionine gamma-synthase activity
U712_RS06195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS06200	COG5505	Protein of unknown function (DUF819)
U712_RS06220	COG3677	Transposase
U712_RS06235	COG5484	DNA packaging
U712_RS06240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
U712_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS06255	COG3711	transcriptional antiterminator
U712_RS06255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS06260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_RS06260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_RS06260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS06265	COG1482	cell wall glycoprotein biosynthetic process
U712_RS06275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS06285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U712_RS06300	COG0109	protoheme IX farnesyltransferase activity
U712_RS06310	COG0726	polysaccharide deacetylase
U712_RS06320	COG5504	Zn-dependent protease
U712_RS06325	COG2205	protein histidine kinase activity
U712_RS06335	COG3383	formate dehydrogenase (NAD+) activity
U712_RS06340	COG2427	Protein of unknown function (DUF1641)
U712_RS06350	COG1051	belongs to the nudix hydrolase family
U712_RS06360	COG2124	cytochrome p450
U712_RS06365	COG1819	glycosyl
U712_RS06375	COG1587	Uroporphyrinogen-III synthase
U712_RS06380	COG0390	transport system, permease component
U712_RS06385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_RS06390	COG0697	spore germination
U712_RS06395	COG4297	protein containing double-stranded beta helix domain
U712_RS06405	COG1252	NADH dehydrogenase
U712_RS06410	COG1904	glucuronate isomerase
U712_RS06415	COG2211	Major facilitator Superfamily
U712_RS06420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
U712_RS06425	COG1063	alcohol dehydrogenase
U712_RS06430	COG1312	Catalyzes the dehydration of D-mannonate
U712_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS06440	COG2271	Major facilitator Superfamily
U712_RS06445	COG1609	Transcriptional regulator
U712_RS06450	COG0246	Mannitol dehydrogenase
U712_RS06455	COG2721	sulfolactate sulfo-lyase activity
U712_RS06460	COG0730	response to heat
U712_RS06465	COG2318	DinB family
U712_RS06470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U712_RS06475	COG0457	Tetratricopeptide repeat
U712_RS06485	COG2350	Protein conserved in bacteria
U712_RS06490	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_RS06490	COG1388	LysM domain
U712_RS06490	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS06500	COG4195	phage-related replication protein
U712_RS06505	COG3546	catalase activity
U712_RS06510	COG2856	Zn peptidase
U712_RS06515	COG1396	sequence-specific DNA binding
U712_RS06525	COG1522	sequence-specific DNA binding
U712_RS06530	COG1484	DNA-dependent DNA replication
U712_RS06545	COG1595	DNA-templated transcription, initiation
U712_RS06550	COG5484	DNA packaging
U712_RS06550	COG3728	DNA packaging
U712_RS06555	COG1783	phage Terminase large subunit
U712_RS06560	COG5518	Phage portal protein
U712_RS06565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U712_RS06570	COG4653	Phage capsid family
U712_RS06615	COG5412	phage tail tape measure protein
U712_RS06615	COG3953	SLT domain
U712_RS06620	COG1652	LysM domain
U712_RS06625	COG4193	domain, Protein
U712_RS06635	COG3628	GPW Gp25 family protein
U712_RS06640	COG3299	homolog of phage Mu protein gp47
U712_RS06645	COG3778	Protein conserved in bacteria
U712_RS06685	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS06685	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_RS06700	COG0306	phosphate transporter
U712_RS06705	COG1392	Phosphate transport regulator
U712_RS06710	COG0531	amino acid
U712_RS06715	COG0346	lactoylglutathione lyase activity
U712_RS06720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U712_RS06725	COG0463	Glycosyl transferase, family 2
U712_RS06730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_RS06735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_RS06740	COG2362	D-Aminopeptidase
U712_RS06745	COG0601	transmembrane transport
U712_RS06750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_RS06755	COG0444	Belongs to the ABC transporter superfamily
U712_RS06760	COG4166	transmembrane transport
U712_RS06765	COG1619	proteins homologs of microcin C7 resistance protein MccF
U712_RS06770	COG4948	Mandelate Racemase Muconate Lactonizing
U712_RS06775	COG0791	NLP P60 protein
U712_RS06780	COG4608	Belongs to the ABC transporter superfamily
U712_RS06785	COG2706	6-phosphogluconolactonase activity
U712_RS06790	COG1834	amidinotransferase
U712_RS06795	COG1607	acyl-coa hydrolase
U712_RS06800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U712_RS06800	COG1017	nitric oxide dioxygenase activity
U712_RS06810	COG2323	membrane
U712_RS06815	COG2318	DinB family
U712_RS06820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS06825	COG2076	Multidrug Resistance protein
U712_RS06830	COG2076	Multidrug Resistance protein
U712_RS06835	COG0788	formyltetrahydrofolate deformylase activity
U712_RS06840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
U712_RS06845	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U712_RS06850	COG1764	response to oxidative stress
U712_RS06855	COG1846	Transcriptional regulator
U712_RS06860	COG1764	response to oxidative stress
U712_RS06870	COG0590	tRNA wobble adenosine to inosine editing
U712_RS06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_RS06880	COG1404	Belongs to the peptidase S8 family
U712_RS06885	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS06890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
U712_RS06895	COG1122	ATPase activity
U712_RS06900	COG4721	ABC-type cobalt transport system, permease component
U712_RS06910	COG0745	RESPONSE REGULATOR receiver
U712_RS06915	COG5002	protein histidine kinase activity
U712_RS06915	COG3850	Histidine kinase
U712_RS06920	COG3212	peptidase
U712_RS06925	COG3212	peptidase
U712_RS06935	COG2239	Acts as a magnesium transporter
U712_RS06940	COG0789	Transcriptional regulator
U712_RS06950	COG1846	Transcriptional regulator
U712_RS06955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_RS06960	COG0726	polysaccharide deacetylase
U712_RS06965	COG1408	metallophosphoesterase
U712_RS06975	COG0463	Glycosyl transferase, family 2
U712_RS06980	COG1793	dna ligase
U712_RS06980	COG3285	dna ligase
U712_RS06985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
U712_RS06990	COG5001	Diguanylate cyclase
U712_RS06990	COG3300	MHYT domain
U712_RS06995	COG0586	Pfam SNARE associated Golgi protein
U712_RS07000	COG0861	Integral membrane protein TerC family
U712_RS07005	COG1191	sigma factor activity
U712_RS07025	COG0501	Belongs to the peptidase M48B family
U712_RS07030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U712_RS07035	COG3594	Acyltransferase
U712_RS07040	COG5002	protein histidine kinase activity
U712_RS07045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U712_RS07050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
U712_RS07055	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
U712_RS07060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U712_RS07065	COG0436	Aminotransferase
U712_RS07070	COG1850	ribulose-bisphosphate carboxylase activity
U712_RS07075	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
U712_RS07080	COG0235	Class ii aldolase
U712_RS07085	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
U712_RS07090	COG3339	Conserved Protein
U712_RS07105	COG3852	Histidine kinase
U712_RS07110	COG1846	Transcriptional regulator
U712_RS07115	COG1360	Flagellar Motor Protein
U712_RS07120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U712_RS07125	COG0542	response to heat
U712_RS07130	COG3949	Membrane
U712_RS07135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U712_RS07140	COG0720	synthase
U712_RS07145	COG0602	queuosine metabolic process
U712_RS07150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U712_RS07155	COG1733	regulation of RNA biosynthetic process
U712_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS07165	COG4641	Protein conserved in bacteria
U712_RS07165	COG1388	LysM domain
U712_RS07170	COG1388	LysM domain
U712_RS07175	COG3858	chitin binding
U712_RS07180	COG3858	chitin binding
U712_RS07190	COG4873	Protein conserved in bacteria
U712_RS07200	COG3773	Cell wall hydrolase
U712_RS07205	COG2244	polysaccharide biosynthetic process
U712_RS07210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS07215	COG2217	Heavy metal translocating P-type atpase
U712_RS07225	COG0006	proline dipeptidase activity
U712_RS07230	COG1609	Transcriptional regulator
U712_RS07235	COG3711	transcriptional antiterminator
U712_RS07240	COG1263	PTS System
U712_RS07240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS07240	COG2190	(PTS) system
U712_RS07245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS07250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U712_RS07260	COG1533	DNA photolyase activity
U712_RS07265	COG0456	acetyltransferase
U712_RS07270	COG0840	transmembrane signaling receptor activity
U712_RS07275	COG2084	Dehydrogenase
U712_RS07280	COG2340	Cysteine-rich secretory protein family
U712_RS07285	COG0768	penicillin binding
U712_RS07290	COG4191	Histidine kinase
U712_RS07295	COG0436	Aminotransferase
U712_RS07300	COG0835	chemotaxis
U712_RS07300	COG0784	Response regulator, receiver
U712_RS07310	COG2814	Major facilitator Superfamily
U712_RS07315	COG1376	ErfK ybiS ycfS ynhG family protein
U712_RS07320	COG1408	metallophosphoesterase
U712_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS07330	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS07335	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS07345	COG2200	EAL domain
U712_RS07350	COG4703	Protein of unknown function (DUF1797)
U712_RS07355	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
U712_RS07365	COG0517	IMP dehydrogenase activity
U712_RS07370	COG0583	DNA-binding transcription factor activity
U712_RS07375	COG0716	FMN binding
U712_RS07385	COG0716	FMN binding
U712_RS07390	COG2171	N-acyltransferase activity
U712_RS07395	COG1473	amidohydrolase
U712_RS07405	COG0668	transmembrane transport
U712_RS07410	COG0450	alkyl hydroperoxide reductase
U712_RS07415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS07430	COG0746	molybdenum cofactor guanylyltransferase activity
U712_RS07435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U712_RS07440	COG0303	'Molybdopterin
U712_RS07445	COG1763	Mo-molybdopterin cofactor biosynthetic process
U712_RS07450	COG0314	molybdopterin synthase activity
U712_RS07455	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U712_RS07460	COG1132	(ABC) transporter
U712_RS07465	COG1132	(ABC) transporter
U712_RS07475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U712_RS07480	COG1136	(ABC) transporter
U712_RS07485	COG0577	efflux transmembrane transporter activity
U712_RS07490	COG1349	DNA-binding transcription factor activity
U712_RS07495	COG1105	Belongs to the carbohydrate kinase PfkB family
U712_RS07500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_RS07500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS07500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_RS07505	COG0681	Belongs to the peptidase S26 family
U712_RS07515	COG0488	(ABC) transporter
U712_RS07520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U712_RS07525	COG2309	aminopeptidase activity
U712_RS07530	COG1077	Cell shape determining protein MreB Mrl
U712_RS07535	COG2002	toxin-antitoxin pair type II binding
U712_RS07540	COG3852	Histidine kinase
U712_RS07545	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
U712_RS07545	COG2105	PFAM AIG2 family protein
U712_RS07550	COG0569	domain protein
U712_RS07555	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
U712_RS07560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U712_RS07565	COG5503	Protein of unknown function (DUF1447)
U712_RS07570	COG0561	phosphatase activity
U712_RS07575	COG0242	peptide deformylase activity
U712_RS07585	COG0497	DNA recombination
U712_RS07590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_RS07595	COG0022	dehydrogenase e1 component
U712_RS07600	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_RS07605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_RS07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS07615	COG1982	Orn Lys Arg decarboxylase major
U712_RS07620	COG4476	Belongs to the UPF0223 family
U712_RS07625	COG4493	Belongs to the UPF0637 family
U712_RS07635	COG0483	inositol monophosphate 1-phosphatase activity
U712_RS07645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
U712_RS07665	COG1595	DNA-templated transcription, initiation
U712_RS07685	COG1217	gtp-binding protein TYPA
U712_RS07695	COG4896	Protein conserved in bacteria
U712_RS07705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
U712_RS07710	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U712_RS07715	COG2066	Belongs to the glutaminase family
U712_RS07720	COG4838	Belongs to the UPF0358 family
U712_RS07725	COG0772	Belongs to the SEDS family
U712_RS07730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
U712_RS07735	COG1612	heme a metabolic process
U712_RS07740	COG0109	protoheme IX farnesyltransferase activity
U712_RS07745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U712_RS07745	COG2010	Cytochrome c
U712_RS07750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U712_RS07755	COG1845	cytochrome c oxidase, subunit III
U712_RS07760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U712_RS07765	COG3336	cytochrome c oxidase
U712_RS07775	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
U712_RS07780	COG2340	Cysteine-rich secretory protein family
U712_RS07795	COG3679	Belongs to the UPF0342 family
U712_RS07800	COG4471	UPF0298 protein
U712_RS07805	COG0742	ribosomal rna small subunit methyltransferase
U712_RS07810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
U712_RS07815	COG3314	Sporulation integral membrane protein YlbJ
U712_RS07820	COG1752	Esterase of the alpha-beta hydrolase superfamily
U712_RS07825	COG3480	Lon protease (S16) C-terminal proteolytic domain
U712_RS07830	COG1323	Belongs to the UPF0348 family
U712_RS07840	COG1399	metal-binding, possibly nucleic acid-binding protein
U712_RS07850	COG0454	-acetyltransferase
U712_RS07855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U712_RS07860	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
U712_RS07865	COG2001	Belongs to the MraZ family
U712_RS07870	COG0275	rRNA processing
U712_RS07875	COG4839	cell division protein FtsL
U712_RS07880	COG0768	penicillin binding
U712_RS07885	COG0768	penicillin binding
U712_RS07890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U712_RS07895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U712_RS07900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U712_RS07905	COG0772	Belongs to the SEDS family
U712_RS07910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_RS07915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U712_RS07920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U712_RS07925	COG3879	Bacterial protein of unknown function (DUF881)
U712_RS07930	COG3879	Bacterial protein of unknown function (DUF881)
U712_RS07935	COG3856	small basic protein
U712_RS07940	COG0849	cell division
U712_RS07945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U712_RS07950	COG4412	M6 family metalloprotease domain protein
U712_RS07950	COG1404	Belongs to the peptidase S8 family
U712_RS07960	COG1191	sigma factor activity
U712_RS07965	COG1191	sigma factor activity
U712_RS07970	COG1119	ATPase activity
U712_RS07975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_RS07980	COG1873	PFAM PRC-barrel domain
U712_RS07985	COG1496	oxidoreductase activity
U712_RS07990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U712_RS07995	COG1799	cell septum assembly
U712_RS08000	COG0762	integral membrane protein
U712_RS08005	COG2302	S4 RNA-binding domain
U712_RS08010	COG3599	regulation of cell shape
U712_RS08015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U712_RS08020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_RS08025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U712_RS08030	COG0564	pseudouridine synthase activity
U712_RS08035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
U712_RS08040	COG2233	PERMEase
U712_RS08045	COG0540	Belongs to the ATCase OTCase family
U712_RS08050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U712_RS08055	COG0505	Belongs to the CarA family
U712_RS08060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U712_RS08065	COG0543	2 iron, 2 sulfur cluster binding
U712_RS08070	COG0167	dihydroorotate dehydrogenase activity
U712_RS08075	COG0284	orotidine-5'-phosphate decarboxylase activity
U712_RS08080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
U712_RS08085	COG0175	sulfate reduction
U712_RS08090	COG0306	phosphate transporter
U712_RS08095	COG2046	Belongs to the sulfate adenylyltransferase family
U712_RS08100	COG0529	Catalyzes the synthesis of activated sulfate
U712_RS08105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U712_RS08110	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
U712_RS08115	COG1648	precorrin-2 dehydrogenase activity
U712_RS08120	COG1293	RNA-binding protein homologous to eukaryotic snRNP
U712_RS08125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U712_RS08130	COG1561	YicC-like family, N-terminal region
U712_RS08140	COG0194	GDP metabolic process
U712_RS08145	COG1758	RNA polymerase activity
U712_RS08150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U712_RS08155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U712_RS08160	COG0242	peptide deformylase activity
U712_RS08165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U712_RS08170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U712_RS08170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U712_RS08175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U712_RS08180	COG0631	protein serine/threonine phosphatase activity
U712_RS08185	COG2815	serine threonine protein kinase
U712_RS08185	COG0515	serine threonine protein kinase
U712_RS08190	COG1162	GTPase activity
U712_RS08195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U712_RS08200	COG1564	THIamine pyrophosphokinase
U712_RS08210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
U712_RS08215	COG1302	Protein conserved in bacteria
U712_RS08220	COG1461	Dihydroxyacetone kinase
U712_RS08225	COG1760	l-serine dehydratase
U712_RS08230	COG1760	l-serine dehydratase
U712_RS08235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U712_RS08240	COG1349	DNA-binding transcription factor activity
U712_RS08240	COG2050	protein possibly involved in aromatic compounds catabolism
U712_RS08245	COG0416	fatty acid biosynthetic process
U712_RS08250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS08265	COG0571	ribonuclease III activity
U712_RS08270	COG1196	nuclear chromosome segregation
U712_RS08275	COG0552	protein localization to endoplasmic reticulum
U712_RS08285	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
U712_RS08290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U712_RS08295	COG0228	four-way junction DNA binding
U712_RS08300	COG1837	Belongs to the UPF0109 family
U712_RS08310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U712_RS08315	COG0336	Belongs to the RNA methyltransferase TrmD family
U712_RS08320	COG0335	large ribosomal subunit rRNA binding
U712_RS08325	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U712_RS08330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U712_RS08340	COG2257	FlhB HrpN YscU SpaS Family
U712_RS08345	COG0045	succinate-CoA ligase (ADP-forming) activity
U712_RS08350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U712_RS08355	COG0758	DNA mediated transformation
U712_RS08360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U712_RS08365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
U712_RS08370	COG4974	Belongs to the 'phage' integrase family
U712_RS08375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
U712_RS08380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
U712_RS08385	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
U712_RS08390	COG1815	bacterial-type flagellum-dependent cell motility
U712_RS08395	COG1558	bacterial-type flagellum-dependent cell motility
U712_RS08400	COG1677	Flagellar hook-basal body complex protein FliE
U712_RS08405	COG1766	The M ring may be actively involved in energy transduction
U712_RS08410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_RS08415	COG1317	bacterial-type flagellum organization
U712_RS08420	COG1157	protein secretion by the type III secretion system
U712_RS08425	COG2882	bacterial-type flagellum organization
U712_RS08430	COG3334	PFAM MgtE intracellular
U712_RS08435	COG3144	bacterial-type flagellum assembly
U712_RS08440	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
U712_RS08445	COG4786	Flagellar basal body rod
U712_RS08450	COG1582	Flagellar protein (FlbD)
U712_RS08455	COG1580	Controls the rotational direction of flagella during chemotaxis
U712_RS08460	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_RS08465	COG1776	CheC inhibitor of MCP methylation
U712_RS08465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_RS08470	COG2201	protein-glutamate methylesterase activity
U712_RS08475	COG3190	flagellar
U712_RS08480	COG1338	Plays a role in the flagellum-specific transport system
U712_RS08485	COG1987	bacterial-type flagellum assembly
U712_RS08490	COG1684	flagellar biosynthetic protein fliR
U712_RS08495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U712_RS08500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U712_RS08505	COG1419	protein localization to endoplasmic reticulum
U712_RS08510	COG0455	bacterial-type flagellum organization
U712_RS08515	COG2201	protein-glutamate methylesterase activity
U712_RS08520	COG2198	Histidine kinase
U712_RS08520	COG0643	Histidine kinase
U712_RS08525	COG0835	chemotaxis
U712_RS08530	COG1776	CheC inhibitor of MCP methylation
U712_RS08535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U712_RS08540	COG1191	sigma factor activity
U712_RS08550	COG0052	Belongs to the universal ribosomal protein uS2 family
U712_RS08555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
U712_RS08560	COG0528	UMP kinase activity
U712_RS08565	COG0233	cytoplasmic translational termination
U712_RS08570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U712_RS08575	COG4589	Belongs to the CDS family
U712_RS08580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U712_RS08585	COG0750	zinc metalloprotease
U712_RS08590	COG0442	prolyl-tRNA aminoacylation
U712_RS08595	COG2176	DNA-directed DNA polymerase activity
U712_RS08600	COG0779	Required for maturation of 30S ribosomal subunits
U712_RS08605	COG0195	Participates in both transcription termination and antitermination
U712_RS08610	COG2740	Nucleic-acid-binding protein implicated in transcription termination
U712_RS08615	COG1358	cellular component organization or biogenesis
U712_RS08620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
U712_RS08625	COG1550	Protein conserved in bacteria
U712_RS08630	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
U712_RS08635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
U712_RS08640	COG0196	riboflavin kinase activity
U712_RS08645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
U712_RS08650	COG1185	polyribonucleotide nucleotidyltransferase activity
U712_RS08655	COG0726	polysaccharide deacetylase
U712_RS08660	COG0612	Peptidase, M16
U712_RS08665	COG1873	PFAM PRC-barrel domain
U712_RS08670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U712_RS08675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U712_RS08680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U712_RS08685	COG0527	aspartate kinase activity
U712_RS08690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U712_RS08695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U712_RS08700	COG0740	serine-type endopeptidase activity
U712_RS08710	COG4980	gas vesicle protein
U712_RS08710	COG1674	ftsk spoiiie
U712_RS08715	COG2188	Transcriptional regulator
U712_RS08720	COG2814	Major facilitator Superfamily
U712_RS08725	COG0612	Peptidase, M16
U712_RS08730	COG0612	Peptidase, M16
U712_RS08735	COG0300	oxidoreductase activity
U712_RS08750	COG1426	Protein conserved in bacteria
U712_RS08755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U712_RS08760	COG1546	Belongs to the CinA family
U712_RS08760	COG1058	Belongs to the CinA family
U712_RS08765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
U712_RS08770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_RS08775	COG1418	mRNA catabolic process
U712_RS08780	COG1692	metallophosphoesterase
U712_RS08785	COG2359	stage V sporulation protein S
U712_RS08790	COG1063	alcohol dehydrogenase
U712_RS08795	COG0156	8-amino-7-oxononanoate synthase activity
U712_RS08800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U712_RS08805	COG4550	Control of competence regulator ComK, YlbF/YmcA
U712_RS08815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U712_RS08820	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
U712_RS08835	COG3226	Transcriptional regulator
U712_RS08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS08850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_RS08855	COG3321	synthase
U712_RS08860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_RS08860	COG2070	2-Nitropropane dioxygenase
U712_RS08865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_RS08870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U712_RS08875	COG3425	synthase
U712_RS08880	COG1024	Enoyl-CoA hydratase
U712_RS08885	COG1024	Enoyl-CoA hydratase
U712_RS08890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS08890	COG3321	synthase
U712_RS08890	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS08890	COG0300	oxidoreductase activity
U712_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS08895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_RS08895	COG3321	synthase
U712_RS08895	COG4221	oxidoreductase activity
U712_RS08895	COG0300	oxidoreductase activity
U712_RS08900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS08900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS08900	COG3321	synthase
U712_RS08900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_RS08910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
U712_RS08910	COG3321	synthase
U712_RS08910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U712_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_RS08915	COG2124	cytochrome p450
U712_RS08925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS08930	COG1404	Belongs to the peptidase S8 family
U712_RS08935	COG4195	phage-related replication protein
U712_RS08940	COG1764	response to oxidative stress
U712_RS08945	COG2076	Multidrug Resistance protein
U712_RS08950	COG2076	Multidrug Resistance protein
U712_RS08965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
U712_RS08970	COG1923	regulation of RNA biosynthetic process
U712_RS08985	COG1780	Probably involved in ribonucleotide reductase function
U712_RS08990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U712_RS08995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U712_RS09000	COG4112	unkown
U712_RS09005	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS09010	COG0464	growth
U712_RS09015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U712_RS09020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
U712_RS09025	COG0789	Transcriptional regulator
U712_RS09030	COG0174	glutamine synthetase
U712_RS09050	COG4282	regulation of fungal-type cell wall biogenesis
U712_RS09060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS09085	COG0135	phosphoribosylanthranilate isomerase activity
U712_RS09090	COG2211	Major facilitator Superfamily
U712_RS09095	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_RS09100	COG1940	carbohydrate kinase activity
U712_RS09105	COG2115	Belongs to the xylose isomerase family
U712_RS09110	COG1070	Carbohydrate kinase
U712_RS09115	COG1525	nuclease
U712_RS09120	COG2814	Major facilitator Superfamily
U712_RS09125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U712_RS09135	COG0756	dUTP diphosphatase activity
U712_RS09145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U712_RS09170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_RS09180	COG3832	glyoxalase III activity
U712_RS09190	COG0697	spore germination
U712_RS09195	COG0531	amino acid
U712_RS09225	COG4195	phage-related replication protein
U712_RS09235	COG0346	lactoylglutathione lyase activity
U712_RS09240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U712_RS09245	COG1388	LysM domain
U712_RS09250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_RS09255	COG4224	UPF0291 protein
U712_RS09260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U712_RS09270	COG3763	UPF0154 protein
U712_RS09280	COG0785	Cytochrome C biogenesis protein
U712_RS09285	COG2201	protein-glutamate methylesterase activity
U712_RS09290	COG4846	Membrane protein involved in cytochrome C biogenesis
U712_RS09300	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_RS09315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
U712_RS09320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS09335	COG0824	Thioesterase
U712_RS09345	COG4841	protein insertion into membrane
U712_RS09350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U712_RS09355	COG1832	CoA-binding protein
U712_RS09360	COG0187	DNA topoisomerase II activity
U712_RS09365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U712_RS09375	COG1115	amino acid carrier protein
U712_RS09380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
U712_RS09390	COG5520	Belongs to the glycosyl hydrolase 30 family
U712_RS09395	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_RS09405	COG2246	polysaccharide biosynthetic process
U712_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_RS09415	COG0586	Pfam SNARE associated Golgi protein
U712_RS09420	COG2404	hydrolase activity, acting on ester bonds
U712_RS09425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U712_RS09430	COG1024	Enoyl-CoA hydratase
U712_RS09435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U712_RS09440	COG0511	ligase activity, forming carbon-carbon bonds
U712_RS09445	COG0439	Biotin carboxylase
U712_RS09450	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS09455	COG1960	acyl-CoA dehydrogenase activity
U712_RS09465	COG1649	PFAM Uncharacterised BCR, COG1649
U712_RS09475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS09475	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
U712_RS09480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS09485	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS09490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS09495	COG2027	D-alanyl-D-alanine carboxypeptidase
U712_RS09500	COG2017	converts alpha-aldose to the beta-anomer
U712_RS09505	COG0534	Mate efflux family protein
U712_RS09520	COG0582	viral genome integration into host DNA
U712_RS09525	COG0166	Belongs to the GPI family
U712_RS09530	COG0405	Gamma-glutamyltransferase
U712_RS09535	COG0583	DNA-binding transcription factor activity
U712_RS09540	COG0604	alcohol dehydrogenase
U712_RS09545	COG0493	'glutamate synthase
U712_RS09550	COG0069	glutamate synthase activity
U712_RS09550	COG0070	glutamate synthase
U712_RS09550	COG0067	glutamate synthase
U712_RS09555	COG0583	DNA-binding transcription factor activity
U712_RS09560	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
U712_RS09565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_RS09575	COG0300	oxidoreductase activity
U712_RS09580	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
U712_RS09590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_RS09595	COG2814	Major facilitator Superfamily
U712_RS09600	COG1070	Carbohydrate kinase
U712_RS09605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U712_RS09610	COG0243	molybdopterin cofactor binding
U712_RS09635	COG0840	transmembrane signaling receptor activity
U712_RS09635	COG5278	phosphoserine phosphatase activity
U712_RS09640	COG2368	4-hydroxyphenylacetate
U712_RS09645	COG4305	rare lipoprotein A
U712_RS09650	COG3619	membrane
U712_RS09655	COG3866	Pectate lyase
U712_RS09660	COG2135	peptidase activity
U712_RS09670	COG2140	Oxalate decarboxylase
U712_RS09680	COG0456	acetyltransferase
U712_RS09695	COG2720	vancomycin resistance protein
U712_RS09705	COG3655	Transcriptional regulator
U712_RS09710	COG3739	integral membrane protein
U712_RS09715	COG0583	DNA-binding transcription factor activity
U712_RS09720	COG0697	spore germination
U712_RS09730	COG0693	protein deglycase activity
U712_RS09735	COG2367	Beta-lactamase
U712_RS09750	COG3848	Pyruvate phosphate dikinase
U712_RS09750	COG0574	Belongs to the PEP-utilizing enzyme family
U712_RS09755	COG0726	polysaccharide deacetylase
U712_RS09760	COG2314	TM2 domain
U712_RS09765	COG1396	sequence-specific DNA binding
U712_RS09780	COG2135	peptidase activity
U712_RS09800	COG0457	Tetratricopeptide repeat
U712_RS09810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_RS09815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_RS09830	COG5290	Psort location Cytoplasmic, score
U712_RS09850	COG5444	nuclease activity
U712_RS09855	COG4282	regulation of fungal-type cell wall biogenesis
U712_RS09860	COG1231	oxidoreductase activity
U712_RS09865	COG5434	Belongs to the glycosyl hydrolase 28 family
U712_RS09870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_RS09875	COG0662	Cupin 2, conserved barrel domain protein
U712_RS09875	COG2207	Transcriptional regulator
U712_RS09880	COG0456	acetyltransferase
U712_RS09885	COG1309	transcriptional regulator
U712_RS09890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS09895	COG3708	Transcriptional regulator
U712_RS09900	COG2378	regulation of single-species biofilm formation
U712_RS09910	COG0640	Transcriptional regulator
U712_RS09915	COG0741	lytic transglycosylase activity
U712_RS09920	COG2322	membrane
U712_RS09935	COG1619	proteins homologs of microcin C7 resistance protein MccF
U712_RS09940	COG3239	Fatty acid desaturase
U712_RS09945	COG4585	Histidine kinase
U712_RS09950	COG2197	response regulator
U712_RS09955	COG3584	3D domain protein
U712_RS09955	COG1388	LysM domain
U712_RS09960	COG0514	ATP-dependent DNA helicase (RecQ)
U712_RS09965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U712_RS09970	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_RS09985	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_RS10010	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS10015	COG1657	PFAM Prenyltransferase squalene oxidase
U712_RS10020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U712_RS10025	COG0733	neurotransmitter:sodium symporter activity
U712_RS10030	COG0385	Bile acid
U712_RS10035	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_RS10040	COG0567	Dehydrogenase, E1 component
U712_RS10045	COG4548	von Willebrand factor, type A
U712_RS10050	COG0714	Associated with various cellular activities
U712_RS10055	COG2032	superoxide dismutase activity
U712_RS10060	COG1388	LysM domain
U712_RS10060	COG0791	NLP P60 protein
U712_RS10065	COG1819	glycosyl
U712_RS10070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
U712_RS10075	COG0534	Mate efflux family protein
U712_RS10080	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS10085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_RS10090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_RS10100	COG2962	Rard protein
U712_RS10115	COG2610	gluconate transmembrane transporter activity
U712_RS10120	COG1942	4-Oxalocrotonate Tautomerase
U712_RS10125	COG1733	regulation of RNA biosynthetic process
U712_RS10130	COG0778	Nitroreductase
U712_RS10135	COG0400	carboxylic ester hydrolase activity
U712_RS10140	COG0346	lactoylglutathione lyase activity
U712_RS10150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_RS10155	COG0793	Belongs to the peptidase S41A family
U712_RS10155	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS10160	COG2226	methyltransferase
U712_RS10170	COG1876	peptidase activity
U712_RS10175	COG0813	purine-nucleoside phosphorylase activity
U712_RS10185	COG0671	phosphoesterase, PA-phosphatase related
U712_RS10200	COG4479	Belongs to the UPF0346 family
U712_RS10210	COG1509	lysine 2,3-aminomutase activity
U712_RS10215	COG0456	acetyltransferase
U712_RS10220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_RS10225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U712_RS10230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U712_RS10235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_RS10245	COG0456	acetyltransferase
U712_RS10250	COG0463	Glycosyl transferase, family 2
U712_RS10265	COG4641	Protein conserved in bacteria
U712_RS10270	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
U712_RS10275	COG1086	Polysaccharide biosynthesis protein
U712_RS10280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U712_RS10285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U712_RS10290	COG1846	Transcriptional regulator
U712_RS10295	COG0534	Mate efflux family protein
U712_RS10305	COG4698	Protein conserved in bacteria
U712_RS10310	COG2755	lipolytic protein G-D-S-L family
U712_RS10315	COG1999	signal sequence binding
U712_RS10325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U712_RS10330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U712_RS10335	COG1272	protein, Hemolysin III
U712_RS10340	COG0204	Acyl-transferase
U712_RS10345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_RS10350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U712_RS10355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U712_RS10365	COG2136	Putative SAM-dependent methyltransferase
U712_RS10365	COG2521	methyltransferase
U712_RS10375	COG0129	dihydroxy-acid dehydratase activity
U712_RS10380	COG1413	lyase activity
U712_RS10385	COG1418	mRNA catabolic process
U712_RS10390	COG0386	Belongs to the glutathione peroxidase family
U712_RS10395	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
U712_RS10400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_RS10405	COG1278	Cold shock
U712_RS10425	COG0328	RNA-DNA hybrid ribonuclease activity
U712_RS10430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
U712_RS10435	COG0328	RNA-DNA hybrid ribonuclease activity
U712_RS10445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_RS10455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
U712_RS10460	COG1755	Isoprenylcysteine carboxyl methyltransferase
U712_RS10465	COG3424	synthase
U712_RS10470	COG2233	PERMEase
U712_RS10475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_RS10480	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
U712_RS10490	COG0800	Aldolase
U712_RS10495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_RS10500	COG1609	Transcriptional regulator
U712_RS10505	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
U712_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS10515	COG1199	ATP-dependent helicase activity
U712_RS10525	COG0116	Belongs to the methyltransferase superfamily
U712_RS10535	COG4474	Belongs to the UPF0398 family
U712_RS10540	COG3359	exonuclease
U712_RS10545	COG1111	helicase
U712_RS10545	COG1205	dead DEAH box helicase
U712_RS10550	COG2190	(PTS) system
U712_RS10555	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_RS10590	COG3331	DNA recombination
U712_RS10595	COG4499	WXG100 protein secretion system (Wss), protein YukC
U712_RS10595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_RS10605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U712_RS10610	COG3935	DnaD domain protein
U712_RS10615	COG0017	Asparaginyl-tRNA synthetase
U712_RS10620	COG0436	Aminotransferase
U712_RS10625	COG5353	protein conserved in bacteria
U712_RS10630	COG1199	ATP-dependent helicase activity
U712_RS10630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U712_RS10635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
U712_RS10640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
U712_RS10645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
U712_RS10655	COG0617	tRNA 3'-terminal CCA addition
U712_RS10660	COG0438	transferase activity, transferring glycosyl groups
U712_RS10665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_RS10670	COG1803	Methylglyoxal synthase
U712_RS10675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
U712_RS10680	COG1694	Mazg nucleotide pyrophosphohydrolase
U712_RS10685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS10695	COG4347	Protein of unknown function (DUF1405)
U712_RS10700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U712_RS10700	COG2010	Cytochrome c
U712_RS10705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U712_RS10710	COG0723	plastoquinol--plastocyanin reductase activity
U712_RS10720	COG5582	Belongs to the UPF0302 family
U712_RS10725	COG0457	Tetratricopeptide repeat
U712_RS10730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
U712_RS10735	COG0287	Prephenate dehydrogenase
U712_RS10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U712_RS10745	COG0159	tryptophan synthase activity
U712_RS10750	COG0133	tryptophan synthase activity
U712_RS10755	COG0135	phosphoribosylanthranilate isomerase activity
U712_RS10765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U712_RS10770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U712_RS10775	COG4401	Chorismate mutase type I
U712_RS10780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
U712_RS10785	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U712_RS10790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U712_RS10795	COG0105	UTP biosynthetic process
U712_RS10800	COG0142	geranyltranstransferase activity
U712_RS10805	COG2226	methyltransferase
U712_RS10810	COG0142	geranyltranstransferase activity
U712_RS10820	COG0302	gtp cyclohydrolase
U712_RS10825	COG0776	regulation of translation
U712_RS10830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
U712_RS10845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
U712_RS10850	COG1160	GTP binding
U712_RS10870	COG1304	FMN binding
U712_RS10875	COG0539	negative regulation of cytoplasmic translation
U712_RS10880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
U712_RS10885	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
U712_RS10890	COG2959	enzyme of heme biosynthesis
U712_RS10895	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS10895	COG3773	Cell wall hydrolase
U712_RS10900	COG2339	peptidase activity
U712_RS10905	COG0492	ferredoxin-NADP+ reductase activity
U712_RS10910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_RS10915	COG4862	establishment of competence for transformation
U712_RS10920	COG1408	metallophosphoesterase
U712_RS10930	COG1388	LysM domain
U712_RS10935	COG1266	CAAX protease self-immunity
U712_RS10940	COG0514	ATP-dependent DNA helicase (RecQ)
U712_RS10945	COG4955	Helix-turn-helix domain
U712_RS10950	COG1141	Ferredoxin
U712_RS10955	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
U712_RS10960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U712_RS10965	COG0710	3-dehydroquinate dehydratase activity
U712_RS10975	COG1595	DNA-templated transcription, initiation
U712_RS10980	COG5002	protein histidine kinase activity
U712_RS10985	COG0745	RESPONSE REGULATOR receiver
U712_RS10990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U712_RS10995	COG1333	cytochrome c biogenesis protein
U712_RS11000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS11005	COG1187	pseudouridine synthase activity
U712_RS11010	COG0700	Nucleoside recognition
U712_RS11015	COG2715	membrane protein required for spore maturation
U712_RS11020	COG1686	Belongs to the peptidase S11 family
U712_RS11030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
U712_RS11035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
U712_RS11040	COG1547	Domain of unknown function (DUF309)
U712_RS11045	COG0456	acetyltransferase
U712_RS11050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U712_RS11055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U712_RS11055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U712_RS11060	COG0307	riboflavin synthase, alpha
U712_RS11065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U712_RS11065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U712_RS11075	COG0681	Belongs to the peptidase S26 family
U712_RS11080	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
U712_RS11100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U712_RS11105	COG4086	secreted protein
U712_RS11110	COG0019	diaminopimelate decarboxylase activity
U712_RS11115	COG0697	spore germination
U712_RS11130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_RS11150	COG1191	sigma factor activity
U712_RS11155	COG2172	sigma factor antagonist activity
U712_RS11160	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS11165	COG1686	Belongs to the peptidase S11 family
U712_RS11170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
U712_RS11175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U712_RS11180	COG4974	Belongs to the 'phage' integrase family
U712_RS11190	COG0735	belongs to the Fur family
U712_RS11195	COG1300	Membrane
U712_RS11205	COG0281	malic enzyme
U712_RS11210	COG1757	Na H antiporter
U712_RS11215	COG1027	Aspartate ammonia-lyase
U712_RS11220	COG0252	asparaginase activity
U712_RS11225	COG1396	sequence-specific DNA binding
U712_RS11230	COG1379	DNA repair
U712_RS11235	COG0494	nUDIX hydrolase
U712_RS11245	COG0667	Aldo Keto reductase
U712_RS11255	COG1073	alpha beta
U712_RS11265	COG4918	Iron-sulphur cluster biosynthesis
U712_RS11270	COG0456	acetyltransferase
U712_RS11270	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
U712_RS11275	COG2329	Antibiotic biosynthesis monooxygenase
U712_RS11280	COG0456	acetyltransferase
U712_RS11290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_RS11300	COG2211	Major facilitator Superfamily
U712_RS11305	COG0346	lactoylglutathione lyase activity
U712_RS11310	COG1072	(Pantothenic acid kinase))
U712_RS11315	COG3048	D-serine ammonia-lyase activity
U712_RS11320	COG0300	oxidoreductase activity
U712_RS11325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS11330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_RS11335	COG4187	Peptidase family M20/M25/M40
U712_RS11340	COG1902	pentaerythritol trinitrate reductase activity
U712_RS11345	COG0596	Alpha beta hydrolase
U712_RS11350	COG1234	tRNA 3'-trailer cleavage
U712_RS11355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U712_RS11360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U712_RS11365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_RS11375	COG0706	membrane insertase activity
U712_RS11380	COG3361	conserved protein (COG2071)
U712_RS11385	COG2195	Cleaves the N-terminal amino acid of tripeptides
U712_RS11390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U712_RS11395	COG0346	lactoylglutathione lyase activity
U712_RS11400	COG1376	ErfK ybiS ycfS ynhG family protein
U712_RS11405	COG4129	membrane
U712_RS11410	COG1126	abc transporter atp-binding protein
U712_RS11415	COG0765	amino acid transport
U712_RS11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS11430	COG1597	lipid kinase activity
U712_RS11435	COG2814	Major facilitator Superfamily
U712_RS11440	COG4978	Transcriptional regulator
U712_RS11440	COG0789	Transcriptional regulator
U712_RS11445	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_RS11450	COG0022	dehydrogenase e1 component
U712_RS11455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_RS11460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_RS11465	COG3426	butyrate kinase activity
U712_RS11470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_RS11475	COG0280	phosphate acetyltransferase
U712_RS11480	COG3290	protein histidine kinase activity
U712_RS11480	COG3829	transcription factor binding
U712_RS11490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
U712_RS11495	COG2079	MmgE PrpD family protein
U712_RS11500	COG0372	Belongs to the citrate synthase family
U712_RS11505	COG1960	acyl-CoA dehydrogenase activity
U712_RS11510	COG1250	3-hydroxyacyl-CoA dehydrogenase
U712_RS11515	COG0183	Belongs to the thiolase family
U712_RS11520	COG0584	glycerophosphoryl diester phosphodiesterase
U712_RS11525	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS11535	COG1902	pentaerythritol trinitrate reductase activity
U712_RS11540	COG0745	RESPONSE REGULATOR receiver
U712_RS11545	COG0750	zinc metalloprotease
U712_RS11550	COG0497	DNA recombination
U712_RS11555	COG1438	arginine binding
U712_RS11560	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
U712_RS11565	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U712_RS11570	COG0142	geranyltranstransferase activity
U712_RS11575	COG1722	exodeoxyribonuclease VII activity
U712_RS11580	COG1570	exodeoxyribonuclease VII activity
U712_RS11585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
U712_RS11590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U712_RS11595	COG1302	Protein conserved in bacteria
U712_RS11600	COG0439	Biotin carboxylase
U712_RS11605	COG0511	ligase activity, forming carbon-carbon bonds
U712_RS11645	COG3854	ATPases associated with a variety of cellular activities
U712_RS11655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U712_RS11660	COG0006	proline dipeptidase activity
U712_RS11665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U712_RS11675	COG3872	metal-dependent enzyme
U712_RS11685	COG1752	Esterase of the alpha-beta hydrolase superfamily
U712_RS11690	COG1321	iron dependent repressor
U712_RS11695	COG0095	Lipoate-protein ligase
U712_RS11700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_RS11705	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U712_RS11710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U712_RS11715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
U712_RS11720	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U712_RS11735	COG1396	sequence-specific DNA binding
U712_RS11745	COG0681	Belongs to the peptidase S26 family
U712_RS11770	COG4940	Competence protein ComGF
U712_RS11780	COG4970	Tfp pilus assembly protein FimT
U712_RS11785	COG4537	Required for transformation and DNA binding
U712_RS11790	COG1459	type II secretion system
U712_RS11795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U712_RS11800	COG0598	Magnesium transport protein CorA
U712_RS11805	COG1253	flavin adenine dinucleotide binding
U712_RS11810	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS11820	COG1393	Belongs to the ArsC family
U712_RS11830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS11840	COG0011	TIGRFAM Protein of
U712_RS11850	COG2866	Carboxypeptidase
U712_RS11855	COG1368	sulfuric ester hydrolase activity
U712_RS11860	COG1940	carbohydrate kinase activity
U712_RS11865	COG4483	Protein conserved in bacteria
U712_RS11870	COG0705	Rhomboid family
U712_RS11870	COG0457	Tetratricopeptide repeat
U712_RS11875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U712_RS11880	COG0438	transferase activity, transferring glycosyl groups
U712_RS11895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U712_RS11900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_RS11905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_RS11910	COG0581	inorganic phosphate transmembrane transporter activity
U712_RS11915	COG0573	inorganic phosphate transmembrane transporter activity
U712_RS11920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U712_RS11925	COG0768	penicillin binding
U712_RS11930	COG0477	Major facilitator Superfamily
U712_RS11935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U712_RS11940	COG2839	Protein conserved in bacteria
U712_RS11945	COG5521	maltodextrose utilization protein MalA
U712_RS11955	COG1388	LysM domain
U712_RS11960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
U712_RS11965	COG4709	membrane
U712_RS11970	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
U712_RS11975	COG0735	belongs to the Fur family
U712_RS11980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS11990	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
U712_RS11995	COG0513	Belongs to the DEAD box helicase family
U712_RS12005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
U712_RS12010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U712_RS12015	COG2384	SAM-dependent methyltransferase
U712_RS12020	COG2010	Cytochrome c
U712_RS12025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U712_RS12030	COG0358	DNA primase activity
U712_RS12035	COG1671	Belongs to the UPF0178 family
U712_RS12040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
U712_RS12045	COG0517	IMP dehydrogenase activity
U712_RS12050	COG0751	glycine-tRNA ligase activity
U712_RS12055	COG0752	glycyl-tRNA synthetase alpha subunit
U712_RS12060	COG1381	Involved in DNA repair and RecF pathway recombination
U712_RS12065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
U712_RS12070	COG0295	cytidine deaminase activity
U712_RS12075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U712_RS12080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
U712_RS12085	COG1480	7TM receptor with intracellular HD hydrolase
U712_RS12090	COG1702	phosphate starvation-inducible protein PhoH
U712_RS12095	COG0561	phosphatase activity
U712_RS12110	COG4864	UPF0365 protein
U712_RS12115	COG1030	water channel activity
U712_RS12120	COG1610	YqeY-like protein
U712_RS12130	COG1283	sodium-dependent phosphate transmembrane transporter activity
U712_RS12135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U712_RS12140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U712_RS12145	COG2264	protein methyltransferase activity
U712_RS12150	COG0484	heat shock protein binding
U712_RS12155	COG0443	Heat shock 70 kDa protein
U712_RS12160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U712_RS12165	COG1420	regulation of RNA biosynthetic process
U712_RS12170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U712_RS12175	COG0481	GTPase activity
U712_RS12185	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS12190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U712_RS12195	COG0268	Binds directly to 16S ribosomal RNA
U712_RS12200	COG1466	dna polymerase III delta subunit
U712_RS12210	COG0658	competence protein
U712_RS12210	COG2333	competence protein COMEC
U712_RS12215	COG2131	deaminase
U712_RS12220	COG1596	polysaccharide export
U712_RS12220	COG1555	photosystem II stabilization
U712_RS12225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_RS12230	COG2226	methyltransferase
U712_RS12235	COG0799	negative regulation of ribosome biogenesis
U712_RS12240	COG1713	HD superfamily hydrolase involved in NAD metabolism
U712_RS12245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U712_RS12250	COG1534	Rna-binding protein
U712_RS12255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U712_RS12260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U712_RS12265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
U712_RS12275	COG2755	lipolytic protein G-D-S-L family
U712_RS12280	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS12280	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_RS12285	COG0398	Pfam SNARE associated Golgi protein
U712_RS12290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
U712_RS12300	COG3209	COG3209 Rhs family protein
U712_RS12310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_RS12315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_RS12320	COG0798	PFAM Bile acid sodium symporter
U712_RS12325	COG0346	lactoylglutathione lyase activity
U712_RS12330	COG0640	Transcriptional regulator
U712_RS12335	COG3403	YqcI/YcgG family
U712_RS12340	COG0457	Tetratricopeptide repeat
U712_RS12350	COG5444	nuclease activity
U712_RS12370	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS12370	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_RS12375	COG4824	toxin secretion phage lysis holin
U712_RS12405	COG3778	Protein conserved in bacteria
U712_RS12410	COG3299	homolog of phage Mu protein gp47
U712_RS12415	COG3628	GPW Gp25 family protein
U712_RS12425	COG4193	domain, Protein
U712_RS12430	COG1652	LysM domain
U712_RS12435	COG3953	SLT domain
U712_RS12435	COG5280	Phage tail tape measure protein TP901
U712_RS12490	COG4653	Phage capsid family
U712_RS12495	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U712_RS12505	COG2369	cell adhesion
U712_RS12510	COG5518	Phage portal protein
U712_RS12515	COG1783	phage Terminase large subunit
U712_RS12520	COG5484	DNA packaging
U712_RS12530	COG3677	Transposase
U712_RS12545	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
U712_RS12550	COG1484	DNA-dependent DNA replication
U712_RS12555	COG3935	DnaD domain protein
U712_RS12560	COG3723	Recombinational DNA repair protein, rece pathway
U712_RS12565	COG5377	YqaJ viral recombinase family
U712_RS12585	COG1476	TRANSCRIPTIONal
U712_RS12590	COG3620	sequence-specific DNA binding
U712_RS12595	COG0563	adenylate kinase activity
U712_RS12600	COG2856	Zn peptidase
U712_RS12610	COG3223	Belongs to the PsiE family
U712_RS12615	COG5002	protein histidine kinase activity
U712_RS12615	COG0642	Histidine kinase
U712_RS12620	COG0745	RESPONSE REGULATOR receiver
U712_RS12625	COG2311	Membrane
U712_RS12630	COG0454	-acetyltransferase
U712_RS12635	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_RS12645	COG0730	response to heat
U712_RS12650	COG0425	Belongs to the sulfur carrier protein TusA family
U712_RS12655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_RS12655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS12665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_RS12665	COG0425	Belongs to the sulfur carrier protein TusA family
U712_RS12670	COG2210	Belongs to the sulfur carrier protein TusA family
U712_RS12675	COG1937	Protein conserved in bacteria
U712_RS12680	COG0662	Cupin 2, conserved barrel domain protein
U712_RS12685	COG0789	Transcriptional regulator
U712_RS12685	COG4978	Transcriptional regulator
U712_RS12690	COG2814	Major facilitator Superfamily
U712_RS12695	COG0456	acetyltransferase
U712_RS12700	COG1253	flavin adenine dinucleotide binding
U712_RS12705	COG0697	spore germination
U712_RS12710	COG0583	DNA-binding transcription factor activity
U712_RS12715	COG2072	flavoprotein involved in K transport
U712_RS12720	COG1230	cation diffusion facilitator family transporter
U712_RS12725	COG1942	4-Oxalocrotonate Tautomerase
U712_RS12730	COG0583	DNA-binding transcription factor activity
U712_RS12740	COG1114	Component of the transport system for branched-chain amino acids
U712_RS12745	COG1687	branched-chain amino acid
U712_RS12750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
U712_RS12755	COG1522	sequence-specific DNA binding
U712_RS12760	COG2732	(Barnase) inhibitor
U712_RS12765	COG2124	cytochrome p450
U712_RS12770	COG1335	isochorismatase
U712_RS12780	COG2318	DinB family
U712_RS12790	COG2070	2-Nitropropane dioxygenase
U712_RS12795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U712_RS12805	COG3443	Belongs to the bacterial solute-binding protein 9 family
U712_RS12810	COG1595	DNA-templated transcription, initiation
U712_RS12815	COG0667	Aldo Keto reductase
U712_RS12820	COG2851	Citrate transporter
U712_RS12825	COG0583	DNA-binding transcription factor activity
U712_RS12830	COG2828	Protein conserved in bacteria
U712_RS12835	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS12840	COG5566	PFAM Mor transcription activator
U712_RS12845	COG0596	Alpha beta hydrolase
U712_RS12850	COG4991	sh3 domain protein
U712_RS12855	COG4991	sh3 domain protein
U712_RS12860	COG0346	lactoylglutathione lyase activity
U712_RS12870	COG5577	PFAM Coat F domain
U712_RS12875	COG1063	alcohol dehydrogenase
U712_RS12885	COG5577	PFAM Coat F domain
U712_RS12890	COG0789	Transcriptional regulator
U712_RS12900	COG1064	alcohol dehydrogenase
U712_RS12905	COG0693	protein deglycase activity
U712_RS12910	COG1621	beta-fructofuranosidase activity
U712_RS12915	COG3716	PTS system mannose fructose sorbose family IID component
U712_RS12920	COG3715	PTS system
U712_RS12925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS12930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS12935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U712_RS12935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
U712_RS12940	COG1113	amino acid transport
U712_RS12945	COG1280	lysine exporter protein (LysE YggA)
U712_RS12950	COG1378	Sugar-specific transcriptional regulator TrmB
U712_RS12955	COG1595	DNA-templated transcription, initiation
U712_RS12965	COG2755	lipolytic protein G-D-S-L family
U712_RS12965	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
U712_RS12975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_RS12975	COG2124	cytochrome p450
U712_RS12980	COG1309	transcriptional regulator
U712_RS12985	COG2226	methyltransferase
U712_RS12990	COG2116	formate transmembrane transporter activity
U712_RS12995	COG5609	conserved protein (DUF2294)
U712_RS13000	COG3383	formate dehydrogenase (NAD+) activity
U712_RS13005	COG2427	Protein of unknown function (DUF1641)
U712_RS13015	COG0626	cystathionine gamma-synthase activity
U712_RS13020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_RS13025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U712_RS13030	COG2226	methyltransferase
U712_RS13045	COG0768	penicillin binding
U712_RS13050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U712_RS13055	COG0572	uridine kinase
U712_RS13060	COG0826	peptidase U32
U712_RS13065	COG0826	peptidase U32
U712_RS13070	COG4122	O-methyltransferase activity
U712_RS13075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U712_RS13080	COG3906	Belongs to the UPF0473 family
U712_RS13085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U712_RS13090	COG4472	Bacterial protein of unknown function (DUF965)
U712_RS13095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U712_RS13100	COG0628	permease
U712_RS13105	COG1126	abc transporter atp-binding protein
U712_RS13110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS13115	COG0765	amino acid transport
U712_RS13120	COG0765	amino acid transport
U712_RS13130	COG3881	PFAM PRC-barrel domain
U712_RS13135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U712_RS13140	COG0457	Tetratricopeptide repeat
U712_RS13145	COG0482	sulfurtransferase activity
U712_RS13150	COG1104	cysteine desulfurase activity
U712_RS13155	COG1959	2 iron, 2 sulfur cluster binding
U712_RS13160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U712_RS13165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U712_RS13170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U712_RS13175	COG0124	histidyl-tRNA synthetase
U712_RS13180	COG3103	Sh3 type 3 domain protein
U712_RS13180	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS13180	COG4991	sh3 domain protein
U712_RS13185	COG1490	D-aminoacyl-tRNA deacylase activity
U712_RS13190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U712_RS13195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_RS13200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
U712_RS13200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
U712_RS13205	COG5416	Lipopolysaccharide assembly protein A domain
U712_RS13210	COG0490	domain, Protein
U712_RS13215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U712_RS13215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U712_RS13225	COG2244	polysaccharide biosynthetic process
U712_RS13230	COG2323	membrane
U712_RS13240	COG1862	Preprotein translocase
U712_RS13245	COG0343	queuine tRNA-ribosyltransferase activity
U712_RS13250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
U712_RS13260	COG2255	four-way junction helicase activity
U712_RS13265	COG0632	four-way junction helicase activity
U712_RS13275	COG2814	Major facilitator Superfamily
U712_RS13280	COG0673	inositol 2-dehydrogenase activity
U712_RS13285	COG2112	serine threonine protein kinase
U712_RS13300	COG1115	amino acid carrier protein
U712_RS13305	COG0217	transcriptional regulatory protein
U712_RS13315	COG1388	LysM domain
U712_RS13320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U712_RS13325	COG0157	Belongs to the NadC ModD family
U712_RS13330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U712_RS13335	COG1104	cysteine desulfurase activity
U712_RS13340	COG1827	regulation of RNA biosynthetic process
U712_RS13345	COG0077	Prephenate dehydratase
U712_RS13350	COG4492	Belongs to the UPF0735 family
U712_RS13355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
U712_RS13360	COG3290	protein histidine kinase activity
U712_RS13365	COG0211	Belongs to the bacterial ribosomal protein bL27 family
U712_RS13370	COG2868	ribosomal protein
U712_RS13375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
U712_RS13380	COG1994	Peptidase M50
U712_RS13385	COG0739	heme binding
U712_RS13390	COG2894	cell division
U712_RS13395	COG0850	regulation of cytokinetic process
U712_RS13400	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U712_RS13410	COG1077	Cell shape determining protein MreB Mrl
U712_RS13415	COG2003	Belongs to the UPF0758 family
U712_RS13420	COG0424	maF-like protein
U712_RS13430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
U712_RS13435	COG0285	dihydrofolate synthase activity
U712_RS13440	COG0525	valine-tRNA ligase activity
U712_RS13450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_RS13455	COG1388	LysM domain
U712_RS13460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U712_RS13465	COG0113	porphobilinogen synthase activity
U712_RS13470	COG1587	Uroporphyrinogen-III synthase
U712_RS13475	COG0181	hydroxymethylbilane synthase activity
U712_RS13480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U712_RS13485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U712_RS13495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U712_RS13500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U712_RS13505	COG0470	DNA polymerase III
U712_RS13505	COG1067	ATP-dependent peptidase activity
U712_RS13510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U712_RS13515	COG0544	peptidyl-prolyl cis-trans isomerase activity
U712_RS13520	COG0457	Tetratricopeptide repeat
U712_RS13520	COG1477	protein flavinylation
U712_RS13525	COG0066	3-isopropylmalate dehydratase activity
U712_RS13530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
U712_RS13535	COG0473	3-isopropylmalate dehydrogenase activity
U712_RS13540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U712_RS13545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U712_RS13550	COG0440	acetolactate synthase activity
U712_RS13555	COG0028	Belongs to the TPP enzyme family
U712_RS13565	COG0454	-acetyltransferase
U712_RS13570	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
U712_RS13580	COG0622	Phosphoesterase
U712_RS13585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U712_RS13590	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
U712_RS13595	COG5401	PFAM Sporulation and spore germination
U712_RS13600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U712_RS13605	COG1846	Transcriptional regulator
U712_RS13610	COG2197	response regulator
U712_RS13615	COG0824	Thioesterase
U712_RS13620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U712_RS13625	COG1053	succinate dehydrogenase
U712_RS13630	COG2009	succinate dehydrogenase
U712_RS13635	COG1719	4-vinyl reductase, 4VR
U712_RS13640	COG0527	aspartate kinase activity
U712_RS13645	COG0322	excinuclease ABC activity
U712_RS13650	COG3118	belongs to the thioredoxin family
U712_RS13655	COG3534	alpha-L-arabinofuranosidase
U712_RS13660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
U712_RS13665	COG2086	electron transfer activity
U712_RS13670	COG1024	Enoyl-CoA hydratase
U712_RS13675	COG1309	transcriptional regulator
U712_RS13680	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS13685	COG3766	membrane
U712_RS13690	COG1193	negative regulation of DNA recombination
U712_RS13695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U712_RS13695	COG1796	DNA polymerase
U712_RS13700	COG1286	toxin biosynthetic process
U712_RS13705	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
U712_RS13710	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U712_RS13715	COG0072	phenylalanine-tRNA ligase activity
U712_RS13715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_RS13720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
U712_RS13730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U712_RS13740	COG3835	regulator
U712_RS13745	COG0277	FAD linked oxidase domain protein
U712_RS13750	COG0247	lactate metabolic process
U712_RS13755	COG0346	lactoylglutathione lyase activity
U712_RS13760	COG1966	Carbon starvation protein
U712_RS13765	COG3534	alpha-L-arabinofuranosidase
U712_RS13770	COG0395	ABC-type sugar transport system, permease component
U712_RS13775	COG1175	transmembrane transport
U712_RS13780	COG1653	transport
U712_RS13785	COG0371	Dehydrogenase
U712_RS13790	COG0647	UMP catabolic process
U712_RS13795	COG0235	Class ii aldolase
U712_RS13800	COG1069	ribulokinase activity
U712_RS13805	COG2160	L-arabinose isomerase activity
U712_RS13810	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_RS13815	COG1363	Peptidase, m42
U712_RS13825	COG3326	Membrane
U712_RS13830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U712_RS13835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
U712_RS13840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U712_RS13850	COG1346	cytolysis
U712_RS13855	COG1380	Effector of murein hydrolase LrgA
U712_RS13860	COG3279	Response regulator of the LytR AlgR family
U712_RS13865	COG3275	phosphorelay sensor kinase activity
U712_RS13870	COG1011	Hydrolase
U712_RS13875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U712_RS13885	COG0398	Pfam SNARE associated Golgi protein
U712_RS13890	COG1484	DNA-dependent DNA replication
U712_RS13895	COG3611	Membrane attachment protein
U712_RS13900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U712_RS13905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
U712_RS13910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U712_RS13915	COG1733	regulation of RNA biosynthetic process
U712_RS13920	COG2814	Major facilitator Superfamily
U712_RS13925	COG0656	L-ascorbic acid biosynthetic process
U712_RS13930	COG0237	dephospho-CoA kinase activity
U712_RS13935	COG1971	Probably functions as a manganese efflux pump
U712_RS13940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
U712_RS13945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_RS13945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_RS13950	COG5002	protein histidine kinase activity
U712_RS13955	COG0745	RESPONSE REGULATOR receiver
U712_RS13960	COG0039	L-malate dehydrogenase activity
U712_RS13965	COG0538	isocitrate dehydrogenase activity
U712_RS13970	COG0372	Belongs to the citrate synthase family
U712_RS13975	COG2707	UPF0756 membrane protein
U712_RS13980	COG0628	permease
U712_RS13985	COG3030	protein affecting phage T7 exclusion by the F plasmid
U712_RS13990	COG0469	pyruvate kinase activity
U712_RS13995	COG0205	6-phosphofructokinase activity
U712_RS14000	COG0825	malonyl-CoA metabolic process
U712_RS14005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U712_RS14010	COG0281	malic enzyme
U712_RS14015	COG0587	DNA-directed DNA polymerase activity
U712_RS14035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
U712_RS14045	COG4109	DRTGG domain
U712_RS14050	COG0730	response to heat
U712_RS14055	COG1473	amidohydrolase
U712_RS14060	COG0196	riboflavin kinase activity
U712_RS14065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS14070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U712_RS14075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS14080	COG1126	abc transporter atp-binding protein
U712_RS14085	COG0765	amino acid transport
U712_RS14090	COG0765	amino acid transport
U712_RS14095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS14100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS14105	COG0454	-acetyltransferase
U712_RS14110	COG0583	DNA-binding transcription factor activity
U712_RS14115	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U712_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS14125	COG0165	Argininosuccinate lyase
U712_RS14130	COG0137	argininosuccinate synthase activity
U712_RS14135	COG0521	Mo-molybdopterin cofactor biosynthetic process
U712_RS14140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U712_RS14145	COG0827	DNA restriction-modification system
U712_RS14150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
U712_RS14155	COG3874	Sporulation protein YtfJ
U712_RS14165	COG1714	RDD family
U712_RS14170	COG0616	signal peptide processing
U712_RS14175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U712_RS14180	COG1574	metal-dependent hydrolase with the TIM-barrel fold
U712_RS14185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U712_RS14195	COG0301	tRNA thio-modification
U712_RS14200	COG1104	cysteine desulfurase activity
U712_RS14205	COG1114	Component of the transport system for branched-chain amino acids
U712_RS14210	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
U712_RS14215	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U712_RS14220	COG1309	transcriptional regulator
U712_RS14225	COG1956	GAF domain-containing protein
U712_RS14230	COG2203	Gaf domain
U712_RS14230	COG2199	diguanylate cyclase activity
U712_RS14235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U712_RS14240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U712_RS14245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U712_RS14250	COG0454	-acetyltransferase
U712_RS14255	COG0517	IMP dehydrogenase activity
U712_RS14260	COG0123	including yeast histone deacetylase and acetoin utilization protein
U712_RS14265	COG1360	Flagellar Motor Protein
U712_RS14270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U712_RS14275	COG1609	Transcriptional regulator
U712_RS14280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
U712_RS14280	COG1605	Chorismate mutase
U712_RS14285	COG3118	belongs to the thioredoxin family
U712_RS14290	COG4980	gas vesicle protein
U712_RS14295	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
U712_RS14300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U712_RS14305	COG1674	ftsk spoiiie
U712_RS14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_RS14315	COG4848	Belongs to the UPF0354 family
U712_RS14320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS14330	COG1363	Peptidase, m42
U712_RS14335	COG5584	Small secreted protein
U712_RS14340	COG0281	malic enzyme
U712_RS14345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS14350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U712_RS14360	COG0510	thiamine kinase activity
U712_RS14365	COG1523	belongs to the glycosyl hydrolase 13 family
U712_RS14370	COG1597	lipid kinase activity
U712_RS14380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U712_RS14385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_RS14390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_RS14395	COG2252	PERMEase
U712_RS14400	COG4473	ABC transporter
U712_RS14405	COG1131	(ABC) transporter
U712_RS14410	COG1349	DNA-binding transcription factor activity
U712_RS14415	COG1187	pseudouridine synthase activity
U712_RS14420	COG2244	polysaccharide biosynthetic process
U712_RS14425	COG2081	HI0933 family
U712_RS14430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
U712_RS14440	COG5578	integral membrane protein
U712_RS14445	COG0673	inositol 2-dehydrogenase activity
U712_RS14450	COG1653	transport
U712_RS14455	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
U712_RS14460	COG4209	transmembrane transport
U712_RS14465	COG2207	Transcriptional regulator
U712_RS14470	COG1653	transport
U712_RS14475	COG0395	ABC-type sugar transport system, permease component
U712_RS14480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_RS14485	COG2124	cytochrome p450
U712_RS14490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U712_RS14495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U712_RS14500	COG0156	8-amino-7-oxononanoate synthase activity
U712_RS14505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_RS14510	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
U712_RS14515	COG1073	alpha beta
U712_RS14520	COG1609	Transcriptional regulator
U712_RS14525	COG1653	transport
U712_RS14530	COG1175	transmembrane transport
U712_RS14535	COG0395	ABC-type sugar transport system, permease component
U712_RS14540	COG1486	melibiose metabolic process
U712_RS14545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_RS14550	COG0495	leucyl-tRNA aminoacylation
U712_RS14560	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_RS14560	COG2202	Pas domain
U712_RS14565	COG2814	Major facilitator Superfamily
U712_RS14570	COG2433	Pfam Transposase IS66
U712_RS14575	COG0577	efflux transmembrane transporter activity
U712_RS14580	COG1136	(ABC) transporter
U712_RS14585	COG2205	protein histidine kinase activity
U712_RS14590	COG0745	RESPONSE REGULATOR receiver
U712_RS14595	COG0577	efflux transmembrane transporter activity
U712_RS14600	COG1136	(ABC) transporter
U712_RS14615	COG1131	(ABC) transporter
U712_RS14620	COG1725	Transcriptional regulator
U712_RS14630	COG1242	4 iron, 4 sulfur cluster binding
U712_RS14635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
U712_RS14645	COG2267	carboxylic ester hydrolase activity
U712_RS14650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U712_RS14655	COG1113	amino acid transport
U712_RS14660	COG0367	asparagine synthase
U712_RS14665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
U712_RS14670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
U712_RS14680	COG1506	peptidase
U712_RS14685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U712_RS14690	COG1116	anion transmembrane transporter activity
U712_RS14695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U712_RS14700	COG0494	nUDIX hydrolase
U712_RS14705	COG4824	toxin secretion phage lysis holin
U712_RS14710	COG0783	Belongs to the Dps family
U712_RS14725	COG1854	S-ribosylhomocysteine lyase activity
U712_RS14730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
U712_RS14735	COG0288	reversible hydration of carbon dioxide
U712_RS14740	COG0254	rRNA binding
U712_RS14745	COG1271	oxidase subunit
U712_RS14750	COG1294	oxidase, subunit
U712_RS14755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_RS14760	COG1321	iron dependent repressor
U712_RS14760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_RS14765	COG1121	(ABC) transporter
U712_RS14770	COG0803	Belongs to the bacterial solute-binding protein 9 family
U712_RS14775	COG4948	Mandelate Racemase Muconate Lactonizing
U712_RS14780	COG0318	PFAM AMP-dependent synthetase and ligase
U712_RS14785	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
U712_RS14790	COG0596	Alpha beta hydrolase
U712_RS14795	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
U712_RS14800	COG1169	isochorismate synthase
U712_RS14805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_RS14810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_RS14815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_RS14820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_RS14825	COG0438	transferase activity, transferring glycosyl groups
U712_RS14835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_RS14840	COG0438	transferase activity, transferring glycosyl groups
U712_RS14845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_RS14850	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
U712_RS14855	COG0058	SHG alpha-glucan phosphorylase activity
U712_RS14860	COG0297	glycogen (starch) synthase activity
U712_RS14865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U712_RS14870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U712_RS14875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
U712_RS15000	COG3859	Proton-coupled thiamine transporter YuaJ
U712_RS15005	COG1247	-acetyltransferase
U712_RS15010	COG2268	Band 7 protein
U712_RS15015	COG1585	Membrane protein implicated in regulation of membrane protease activity
U712_RS15020	COG2318	DinB family
U712_RS15030	COG1454	alcohol dehydrogenase
U712_RS15035	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS15040	COG1510	regulation of RNA biosynthetic process
U712_RS15050	COG0569	domain protein
U712_RS15055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U712_RS15060	COG4682	membrane
U712_RS15065	COG1705	Flagellar rod assembly protein muramidase FlgJ
U712_RS15070	COG0477	Major facilitator Superfamily
U712_RS15075	COG5553	Cysteine dioxygenase type I
U712_RS15085	COG1968	undecaprenyl-diphosphatase activity
U712_RS15090	COG0628	permease
U712_RS15095	COG0673	inositol 2-dehydrogenase activity
U712_RS15100	COG4806	L-rhamnose isomerase
U712_RS15105	COG3254	rhamnose metabolic process
U712_RS15110	COG1070	Carbohydrate kinase
U712_RS15115	COG1349	DNA-binding transcription factor activity
U712_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS15120	COG3347	Dehydrogenase
U712_RS15125	COG0840	transmembrane signaling receptor activity
U712_RS15130	COG0840	transmembrane signaling receptor activity
U712_RS15135	COG0840	transmembrane signaling receptor activity
U712_RS15140	COG0840	transmembrane signaling receptor activity
U712_RS15155	COG0432	Pfam Uncharacterised protein family UPF0047
U712_RS15160	COG0366	Alpha amylase catalytic
U712_RS15165	COG1253	flavin adenine dinucleotide binding
U712_RS15170	COG2738	Putative neutral zinc metallopeptidase
U712_RS15185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U712_RS15200	COG0166	Belongs to the GPI family
U712_RS15205	COG1979	alcohol dehydrogenase
U712_RS15210	COG1979	alcohol dehydrogenase
U712_RS15215	COG2155	Conserved Protein
U712_RS15220	COG1098	S1 RNA binding domain
U712_RS15225	COG0436	Aminotransferase
U712_RS15230	COG1522	sequence-specific DNA binding
U712_RS15235	COG2267	carboxylic ester hydrolase activity
U712_RS15245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U712_RS15250	COG2205	protein histidine kinase activity
U712_RS15260	COG5018	Exonuclease
U712_RS15270	COG2814	Major facilitator Superfamily
U712_RS15275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_RS15280	COG3011	Protein conserved in bacteria
U712_RS15290	COG3290	protein histidine kinase activity
U712_RS15295	COG4565	transcriptional regulatory protein
U712_RS15300	COG1744	ABC transporter substrate-binding protein PnrA-like
U712_RS15305	COG3845	ABC transporter
U712_RS15310	COG4603	Belongs to the binding-protein-dependent transport system permease family
U712_RS15315	COG1079	Belongs to the binding-protein-dependent transport system permease family
U712_RS15320	COG3493	citrate carrier protein
U712_RS15330	COG2111	Na H antiporter
U712_RS15330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U712_RS15335	COG2111	Na H antiporter
U712_RS15340	COG1006	Multisubunit Na H antiporter MnhC subunit
U712_RS15345	COG0651	ATP synthesis coupled electron transport
U712_RS15350	COG1863	multisubunit Na H antiporter MnhE subunit
U712_RS15355	COG2212	antiporter activity
U712_RS15360	COG1320	monovalent cation:proton antiporter activity
U712_RS15365	COG2050	protein possibly involved in aromatic compounds catabolism
U712_RS15370	COG2197	response regulator
U712_RS15375	COG4585	Histidine kinase
U712_RS15385	COG0142	geranyltranstransferase activity
U712_RS15400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
U712_RS15405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
U712_RS15410	COG1335	isochorismatase
U712_RS15415	COG5506	Protein of unknown function (DUF1694)
U712_RS15430	COG0628	permease
U712_RS15445	COG1418	mRNA catabolic process
U712_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS15460	COG1511	domain protein
U712_RS15465	COG1674	ftsk spoiiie
U712_RS15465	COG0433	COG0433 Predicted ATPase
U712_RS15470	COG4499	WXG100 protein secretion system (Wss), protein YukC
U712_RS15475	COG5417	Belongs to the EsaB family
U712_RS15480	COG4842	Belongs to the WXG100 family
U712_RS15485	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
U712_RS15485	COG2508	Transcriptional regulator
U712_RS15490	COG0686	Belongs to the AlaDH PNT family
U712_RS15495	COG5634	Uncharacterized conserved protein (DUF2278)
U712_RS15500	COG3251	PFAM MbtH domain protein
U712_RS15505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS15510	COG3433	isochorismatase activity
U712_RS15510	COG1535	isochorismatase
U712_RS15515	COG1021	2,3-dihydroxybenzoate-AMP ligase
U712_RS15520	COG1169	isochorismate synthase
U712_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS15530	COG2819	hydrolase of the alpha beta superfamily
U712_RS15535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U712_RS15540	COG1268	BioY protein
U712_RS15545	COG2056	Na+-H+ antiporter family
U712_RS15550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U712_RS15555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
U712_RS15560	COG3584	3D domain protein
U712_RS15570	COG1252	NADH dehydrogenase
U712_RS15575	COG0492	ferredoxin-NADP+ reductase activity
U712_RS15580	COG0516	GMP reductase activity
U712_RS15585	COG2808	Putative FMN-binding domain
U712_RS15590	COG0456	acetyltransferase
U712_RS15595	COG0316	Belongs to the HesB IscA family
U712_RS15600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U712_RS15605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_RS15610	COG4844	belongs to the
U712_RS15615	COG1252	NADH dehydrogenase
U712_RS15620	COG4837	Protein of unknown function (DUF1462)
U712_RS15625	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
U712_RS15630	COG0823	Involved in the tonB-independent uptake of proteins
U712_RS15630	COG1506	peptidase
U712_RS15630	COG4946	Tricorn protease homolog
U712_RS15635	COG0083	homoserine kinase activity
U712_RS15640	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U712_RS15645	COG0460	homoserine dehydrogenase
U712_RS15650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_RS15655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U712_RS15660	COG0647	UMP catabolic process
U712_RS15665	COG2445	Protein of unknown function DUF86
U712_RS15670	COG4470	Protein conserved in bacteria
U712_RS15680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
U712_RS15685	COG0739	heme binding
U712_RS15695	COG3377	Domain of unknown function (DUF1805)
U712_RS15700	COG0737	Belongs to the 5'-nucleotidase family
U712_RS15705	COG0730	response to heat
U712_RS15710	COG1801	Protein of unknown function DUF72
U712_RS15720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U712_RS15725	COG2508	Transcriptional regulator
U712_RS15730	COG2233	PERMEase
U712_RS15735	COG2233	PERMEase
U712_RS15740	COG3195	allantoin biosynthetic process
U712_RS15740	COG3648	Uricase
U712_RS15745	COG2351	hydroxyisourate hydrolase activity
U712_RS15755	COG2080	2 iron, 2 sulfur cluster binding
U712_RS15760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U712_RS15765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U712_RS15770	COG2068	MobA-Related Protein
U712_RS15775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U712_RS15780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U712_RS15785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_RS15790	COG2356	endonuclease I
U712_RS15795	COG3842	ATPase activity
U712_RS15800	COG2188	Transcriptional regulator
U712_RS15805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_RS15810	COG0395	ABC-type sugar transport system, permease component
U712_RS15815	COG1175	transmembrane transport
U712_RS15820	COG1653	transport
U712_RS15825	COG2222	sugar isomerase
U712_RS15830	COG0322	excinuclease ABC activity
U712_RS15835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_RS15850	COG0346	lactoylglutathione lyase activity
U712_RS15855	COG0640	Transcriptional regulator
U712_RS15860	COG0719	Fe-S assembly protein
U712_RS15865	COG0822	iron-sulfur transferase activity
U712_RS15870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U712_RS15875	COG0719	Fe-S assembly protein
U712_RS15880	COG0396	ATPase activity
U712_RS15885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U712_RS15890	COG1464	Belongs to the NlpA lipoprotein family
U712_RS15895	COG2011	ABC-type metal ion transport system permease component
U712_RS15900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U712_RS15910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_RS15915	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
U712_RS15925	COG0509	glycine decarboxylation via glycine cleavage system
U712_RS15930	COG1393	Belongs to the ArsC family
U712_RS15935	COG1960	acyl-CoA dehydrogenase activity
U712_RS15940	COG0183	Belongs to the thiolase family
U712_RS15945	COG1024	Enoyl-CoA hydratase
U712_RS15945	COG1250	3-hydroxyacyl-CoA dehydrogenase
U712_RS15950	COG0506	proline dehydrogenase activity
U712_RS15960	COG5577	PFAM Coat F domain
U712_RS15965	COG1846	Transcriptional regulator
U712_RS15970	COG0477	Major facilitator Superfamily
U712_RS15975	COG1942	4-Oxalocrotonate Tautomerase
U712_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS15985	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS15990	COG0583	DNA-binding transcription factor activity
U712_RS16000	COG1120	ATPase activity
U712_RS16020	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS16025	COG0783	Belongs to the Dps family
U712_RS16030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_RS16035	COG0745	RESPONSE REGULATOR receiver
U712_RS16040	COG2770	Histidine kinase
U712_RS16040	COG2205	protein histidine kinase activity
U712_RS16045	COG1309	transcriptional regulator
U712_RS16050	COG0114	fumarate hydratase activity
U712_RS16060	COG0697	spore germination
U712_RS16065	COG0814	amino acid
U712_RS16075	COG2197	response regulator
U712_RS16080	COG4585	Histidine kinase
U712_RS16085	COG4758	membrane
U712_RS16090	COG3595	metallopeptidase activity
U712_RS16095	COG1842	Phage shock protein A
U712_RS16100	COG4758	membrane
U712_RS16105	COG2814	Major facilitator Superfamily
U712_RS16110	COG2096	Adenosyltransferase
U712_RS16115	COG1120	ATPase activity
U712_RS16120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS16125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS16135	COG3386	PFAM SMP-30 Gluconolaconase
U712_RS16140	COG2205	protein histidine kinase activity
U712_RS16145	COG0745	RESPONSE REGULATOR receiver
U712_RS16155	COG1191	sigma factor activity
U712_RS16160	COG2140	Oxalate decarboxylase
U712_RS16170	COG0577	efflux transmembrane transporter activity
U712_RS16175	COG1136	(ABC) transporter
U712_RS16180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U712_RS16185	COG1120	ATPase activity
U712_RS16190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS16195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_RS16200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS16210	COG0531	amino acid
U712_RS16220	COG1988	membrane-bound metal-dependent
U712_RS16225	COG1368	sulfuric ester hydrolase activity
U712_RS16230	COG1910	domain protein
U712_RS16235	COG0725	ABC transporter, periplasmic molybdate-binding protein
U712_RS16240	COG4149	molybdate abc transporter
U712_RS16245	COG0656	L-ascorbic acid biosynthetic process
U712_RS16255	COG0025	NhaP-type Na H and K H
U712_RS16260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_RS16265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_RS16270	COG3973	AAA domain
U712_RS16275	COG2860	membrane
U712_RS16280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U712_RS16285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U712_RS16290	COG2217	Heavy metal translocating P-type atpase
U712_RS16295	COG2217	Heavy metal translocating P-type atpase
U712_RS16300	COG2608	mercury ion transmembrane transporter activity
U712_RS16305	COG1937	Protein conserved in bacteria
U712_RS16310	COG0673	inositol 2-dehydrogenase activity
U712_RS16315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U712_RS16320	COG1289	transmembrane transporter activity
U712_RS16330	COG2076	Multidrug Resistance protein
U712_RS16335	COG1309	transcriptional regulator
U712_RS16340	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS16345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
U712_RS16350	COG0557	exoribonuclease II activity
U712_RS16355	COG1647	Serine aminopeptidase, S33
U712_RS16360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U712_RS16365	COG0596	Alpha beta hydrolase
U712_RS16370	COG1476	TRANSCRIPTIONal
U712_RS16375	COG1396	sequence-specific DNA binding
U712_RS16380	COG1396	sequence-specific DNA binding
U712_RS16385	COG1733	regulation of RNA biosynthetic process
U712_RS16390	COG0840	transmembrane signaling receptor activity
U712_RS16395	COG1174	glycine betaine transport
U712_RS16400	COG1732	Glycine betaine
U712_RS16405	COG1174	glycine betaine transport
U712_RS16410	COG1125	glycine betaine transport
U712_RS16410	COG0517	IMP dehydrogenase activity
U712_RS16415	COG1510	regulation of RNA biosynthetic process
U712_RS16435	COG5658	integral membrane protein
U712_RS16440	COG0640	Transcriptional regulator
U712_RS16445	COG1174	glycine betaine transport
U712_RS16450	COG1732	Glycine betaine
U712_RS16455	COG1174	glycine betaine transport
U712_RS16460	COG0517	IMP dehydrogenase activity
U712_RS16460	COG1125	glycine betaine transport
U712_RS16465	COG1510	regulation of RNA biosynthetic process
U712_RS16470	COG2095	MarC family integral membrane protein
U712_RS16480	COG3064	Membrane
U712_RS16485	COG4640	response to antibiotic
U712_RS16490	COG0456	acetyltransferase
U712_RS16495	COG0148	phosphopyruvate hydratase activity
U712_RS16500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U712_RS16505	COG0149	triose-phosphate isomerase activity
U712_RS16510	COG0126	phosphoglycerate kinase activity
U712_RS16515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U712_RS16520	COG2390	Transcriptional regulator
U712_RS16525	COG2814	Major facilitator Superfamily
U712_RS16530	COG1609	Transcriptional regulator
U712_RS16535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS16540	COG0583	DNA-binding transcription factor activity
U712_RS16545	COG0697	spore germination
U712_RS16550	COG1113	amino acid transport
U712_RS16555	COG3858	chitin binding
U712_RS16560	COG1556	Lactate utilization protein
U712_RS16565	COG1139	Iron-sulfur cluster binding protein
U712_RS16570	COG0247	lactate metabolic process
U712_RS16575	COG2197	response regulator
U712_RS16580	COG4585	Histidine kinase
U712_RS16585	COG0842	Transport permease protein
U712_RS16590	COG1131	(ABC) transporter
U712_RS16595	COG0596	Alpha beta hydrolase
U712_RS16600	COG2208	phosphoserine phosphatase activity
U712_RS16605	COG3867	Arabinogalactan endo-beta-1,4-galactanase
U712_RS16610	COG1874	Beta-galactosidase
U712_RS16615	COG3833	ABC-type maltose transport systems, permease component
U712_RS16620	COG1175	transmembrane transport
U712_RS16625	COG2182	Extracellular solute-binding protein
U712_RS16630	COG1609	Transcriptional regulator
U712_RS16635	COG2186	Transcriptional regulator
U712_RS16640	COG1620	l-lactate permease
U712_RS16645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U712_RS16655	COG5039	Polysaccharide pyruvyl transferase
U712_RS16660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_RS16665	COG0110	maltose O-acetyltransferase activity
U712_RS16670	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U712_RS16675	COG2244	polysaccharide biosynthetic process
U712_RS16680	COG1216	Glycosyl transferase, family 2
U712_RS16685	COG5039	Polysaccharide pyruvyl transferase
U712_RS16690	COG1216	Glycosyl transferase, family 2
U712_RS16700	COG0438	transferase activity, transferring glycosyl groups
U712_RS16705	COG1215	transferase activity, transferring glycosyl groups
U712_RS16710	COG0438	transferase activity, transferring glycosyl groups
U712_RS16715	COG1086	Polysaccharide biosynthesis protein
U712_RS16720	COG0489	protein tyrosine kinase activity
U712_RS16725	COG3944	biosynthesis protein
U712_RS16730	COG1396	sequence-specific DNA binding
U712_RS16735	COG2272	Belongs to the type-B carboxylesterase lipase family
U712_RS16745	COG3479	Phenolic acid decarboxylase
U712_RS16755	COG1794	racemase activity, acting on amino acids and derivatives
U712_RS16760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_RS16765	COG1621	beta-fructofuranosidase activity
U712_RS16770	COG1621	beta-fructofuranosidase activity
U712_RS16775	COG0531	amino acid
U712_RS16780	COG1309	transcriptional regulator
U712_RS16785	COG2076	Multidrug Resistance protein
U712_RS16790	COG2076	Multidrug Resistance protein
U712_RS16800	COG0277	FAD linked oxidase domain protein
U712_RS16805	COG3621	Patatin-like phospholipase
U712_RS16815	COG0740	serine-type endopeptidase activity
U712_RS16820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U712_RS16825	COG0366	Alpha amylase catalytic
U712_RS16830	COG1554	hydrolase, family 65, central catalytic
U712_RS16835	COG5521	maltodextrose utilization protein MalA
U712_RS16840	COG3833	ABC-type maltose transport systems, permease component
U712_RS16845	COG1175	transmembrane transport
U712_RS16850	COG2182	Extracellular solute-binding protein
U712_RS16855	COG0366	Alpha amylase catalytic
U712_RS16860	COG1609	Transcriptional regulator
U712_RS16865	COG1611	Belongs to the LOG family
U712_RS16870	COG1694	Mazg nucleotide pyrophosphohydrolase
U712_RS16875	COG0659	secondary active sulfate transmembrane transporter activity
U712_RS16880	COG0288	reversible hydration of carbon dioxide
U712_RS16885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U712_RS16890	COG0577	efflux transmembrane transporter activity
U712_RS16895	COG1136	(ABC) transporter
U712_RS16900	COG5002	protein histidine kinase activity
U712_RS16905	COG0745	RESPONSE REGULATOR receiver
U712_RS16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
U712_RS16920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS16925	COG1481	regulation of sporulation
U712_RS16930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
U712_RS16935	COG1660	Displays ATPase and GTPase activities
U712_RS16940	COG1051	belongs to the nudix hydrolase family
U712_RS16945	COG0492	ferredoxin-NADP+ reductase activity
U712_RS16950	COG0791	NLP P60 protein
U712_RS16950	COG3883	PFAM NLP P60 protein
U712_RS16955	COG0457	Tetratricopeptide repeat
U712_RS16960	COG1132	(ABC) transporter
U712_RS16980	COG0140	phosphoribosyl-ATP diphosphatase activity
U712_RS16980	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U712_RS16985	COG0107	imidazoleglycerol-phosphate synthase activity
U712_RS16990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
U712_RS16995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U712_RS17000	COG0131	Imidazoleglycerol-phosphate dehydratase
U712_RS17005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U712_RS17010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
U712_RS17015	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
U712_RS17020	COG4990	cell redox homeostasis
U712_RS17025	COG5297	Belongs to the glycosyl hydrolase family 6
U712_RS17030	COG0110	maltose O-acetyltransferase activity
U712_RS17035	COG0546	phosphoglycolate phosphatase activity
U712_RS17040	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
U712_RS17045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
U712_RS17050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
U712_RS17055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U712_RS17060	COG0363	glucosamine-6-phosphate deaminase activity
U712_RS17065	COG2188	Transcriptional regulator
U712_RS17070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U712_RS17075	COG1846	Transcriptional regulator
U712_RS17080	COG2124	cytochrome p450
U712_RS17090	COG1846	Transcriptional regulator
U712_RS17095	COG2814	Major facilitator Superfamily
U712_RS17100	COG1950	PFAM Membrane protein of
U712_RS17105	COG1983	PspC domain protein
U712_RS17110	COG3595	metallopeptidase activity
U712_RS17125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_RS17130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U712_RS17135	COG0556	nucleotide-excision repair
U712_RS17140	COG4897	Protein conserved in bacteria
U712_RS17145	COG0574	Belongs to the PEP-utilizing enzyme family
U712_RS17145	COG3848	Pyruvate phosphate dikinase
U712_RS17150	COG1309	transcriptional regulator
U712_RS17155	COG2814	Major facilitator Superfamily
U712_RS17160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_RS17170	COG3409	Peptidoglycan-binding domain 1 protein
U712_RS17170	COG0793	Belongs to the peptidase S41A family
U712_RS17175	COG2177	Part of the ABC transporter FtsEX involved in
U712_RS17180	COG2884	Cell division ATP-binding protein ftsE
U712_RS17185	COG2010	Cytochrome c
U712_RS17190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS17195	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U712_RS17200	COG0653	protein targeting
U712_RS17205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U712_RS17220	COG1516	flagellar protein fliS
U712_RS17225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
U712_RS17230	COG1334	flagellar protein FlaG
U712_RS17235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_RS17240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U712_RS17245	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
U712_RS17255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_RS17260	COG4786	Flagellar basal body rod
U712_RS17260	COG1256	bacterial-type flagellum assembly
U712_RS17265	COG3418	PFAM FlgN family protein
U712_RS17270	COG2747	anti-sigma28 factor FlgM
U712_RS17280	COG1040	competence protein
U712_RS17290	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
U712_RS17295	COG1307	EDD domain protein, DegV family
U712_RS17300	COG2197	response regulator
U712_RS17305	COG4585	Histidine kinase
U712_RS17310	COG1739	Uncharacterized protein family UPF0029
U712_RS17315	COG1316	TRANSCRIPTIONal
U712_RS17320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U712_RS17325	COG0438	transferase activity, transferring glycosyl groups
U712_RS17330	COG1215	transferase activity, transferring glycosyl groups
U712_RS17335	COG3206	protein involved in exopolysaccharide biosynthesis
U712_RS17340	COG3307	-O-antigen
U712_RS17345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_RS17350	COG0297	glycogen (starch) synthase activity
U712_RS17350	COG0438	transferase activity, transferring glycosyl groups
U712_RS17355	COG2244	polysaccharide biosynthetic process
U712_RS17365	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_RS17365	COG2247	cell wall binding repeat
U712_RS17370	COG2385	sporulation resulting in formation of a cellular spore
U712_RS17370	COG2247	cell wall binding repeat
U712_RS17380	COG1316	TRANSCRIPTIONal
U712_RS17385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
U712_RS17390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_RS17395	COG1215	transferase activity, transferring glycosyl groups
U712_RS17395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_RS17400	COG0463	Glycosyl transferase, family 2
U712_RS17410	COG1134	teichoic acid transport
U712_RS17415	COG1682	transport, permease protein
U712_RS17420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_RS17425	COG0438	transferase activity, transferring glycosyl groups
U712_RS17430	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U712_RS17435	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
U712_RS17440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_RS17450	COG4193	domain, Protein
U712_RS17455	COG1482	cell wall glycoprotein biosynthetic process
U712_RS17460	COG0697	spore germination
U712_RS17465	COG0814	amino acid
U712_RS17475	COG2814	Major facilitator Superfamily
U712_RS17480	COG1316	TRANSCRIPTIONal
U712_RS17485	COG0561	phosphatase activity
U712_RS17490	COG0791	NLP P60 protein
U712_RS17495	COG2843	Capsule synthesis protein
U712_RS17505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U712_RS17510	COG1609	Transcriptional regulator
U712_RS17515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_RS17520	COG1869	D-ribose catabolic process
U712_RS17525	COG1129	ABC transporter
U712_RS17530	COG1172	Belongs to the binding-protein-dependent transport system permease family
U712_RS17535	COG1879	ABC-type sugar transport system periplasmic component
U712_RS17540	COG3103	Sh3 type 3 domain protein
U712_RS17550	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_RS17555	COG3527	Alpha-acetolactate decarboxylase
U712_RS17560	COG0028	Belongs to the TPP enzyme family
U712_RS17565	COG0583	DNA-binding transcription factor activity
U712_RS17570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U712_RS17585	COG5337	Spore coat protein CotH
U712_RS17595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
U712_RS17605	COG0405	Gamma-glutamyltransferase
U712_RS17610	COG1522	sequence-specific DNA binding
U712_RS17615	COG2059	Chromate
U712_RS17620	COG2059	Chromate
U712_RS17630	COG0655	NAD(P)H dehydrogenase (quinone) activity
U712_RS17635	COG0583	DNA-binding transcription factor activity
U712_RS17640	COG1515	deoxyribonuclease V activity
U712_RS17645	COG2849	repeat protein
U712_RS17650	COG5444	nuclease activity
U712_RS17665	COG3878	Protein conserved in bacteria
U712_RS17670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_RS17675	COG4464	protein tyrosine phosphatase activity
U712_RS17680	COG0489	protein tyrosine kinase activity
U712_RS17685	COG3944	biosynthesis protein
U712_RS17690	COG4715	Zinc finger, swim domain protein
U712_RS17695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U712_RS17700	COG0561	phosphatase activity
U712_RS17705	COG1349	DNA-binding transcription factor activity
U712_RS17710	COG0629	single-stranded DNA binding
U712_RS17725	COG3764	Sortase (surface protein transpeptidase)
U712_RS17730	COG0745	RESPONSE REGULATOR receiver
U712_RS17730	COG2972	Histidine kinase
U712_RS17735	COG1970	mechanosensitive ion channel activity
U712_RS17740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U712_RS17745	COG0457	Tetratricopeptide repeat
U712_RS17750	COG4786	Flagellar basal body rod
U712_RS17755	COG4786	Flagellar basal body rod
U712_RS17760	COG1077	Cell shape determining protein MreB Mrl
U712_RS17765	COG1609	Transcriptional regulator
U712_RS17770	COG1846	Transcriptional regulator
U712_RS17775	COG2814	Major facilitator Superfamily
U712_RS17780	COG3420	alginic acid biosynthetic process
U712_RS17785	COG1953	Uracil, thiamine, allantoin
U712_RS17790	COG0477	Major facilitator Superfamily
U712_RS17795	COG1335	isochorismatase
U712_RS17805	COG0004	ammonium transporteR
U712_RS17810	COG0347	Belongs to the P(II) protein family
U712_RS17815	COG0671	phosphoesterase, PA-phosphatase related
U712_RS17825	COG0739	heme binding
U712_RS17830	COG1247	-acetyltransferase
U712_RS17845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_RS17850	COG0789	Transcriptional regulator
U712_RS17860	COG2910	NAD(P)H-binding
U712_RS17865	COG1959	2 iron, 2 sulfur cluster binding
U712_RS17870	COG0804	urea catabolic process
U712_RS17875	COG0832	Belongs to the urease beta subunit family
U712_RS17880	COG0831	urea catabolic process
U712_RS17890	COG3237	CsbD-like
U712_RS17895	COG1994	Peptidase M50
U712_RS17900	COG0457	Tetratricopeptide repeat
U712_RS17905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U712_RS17910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U712_RS17915	COG2304	oxidoreductase activity
U712_RS17925	COG2304	oxidoreductase activity
U712_RS17930	COG2385	sporulation resulting in formation of a cellular spore
U712_RS17935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U712_RS17945	COG4836	Membrane
U712_RS17955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U712_RS17960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U712_RS17965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
U712_RS17970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U712_RS17975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U712_RS17980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U712_RS17990	COG0356	it plays a direct role in the translocation of protons across the membrane
U712_RS18000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
U712_RS18005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U712_RS18010	COG4475	Protein of unknown function (DUF436)
U712_RS18015	COG0698	ribose 5-phosphate isomerase
U712_RS18020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_RS18025	COG1971	Probably functions as a manganese efflux pump
U712_RS18030	COG0009	L-threonylcarbamoyladenylate synthase
U712_RS18035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U712_RS18055	COG2890	protein-(glutamine-N5) methyltransferase activity
U712_RS18060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
U712_RS18065	COG0346	lactoylglutathione lyase activity
U712_RS18070	COG0789	Transcriptional regulator
U712_RS18075	COG0679	Auxin Efflux Carrier
U712_RS18080	COG0281	malic enzyme
U712_RS18085	COG1435	thymidine kinase activity
U712_RS18095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
U712_RS18100	COG1494	fructose-1,6-bisphosphatase
U712_RS18105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U712_RS18110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U712_RS18115	COG0191	fructose-bisphosphate aldolase activity
U712_RS18120	COG2204	response regulator
U712_RS18125	COG4821	SIS domain
U712_RS18130	COG0504	CTP synthase activity
U712_RS18135	COG3343	RNA polymerase activity
U712_RS18140	COG1960	acyl-CoA dehydrogenase activity
U712_RS18145	COG0247	lactate metabolic process
U712_RS18145	COG2181	nitrate reductase activity
U712_RS18150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_RS18155	COG4294	response to UV
U712_RS18165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_RS18170	COG1132	(ABC) transporter
U712_RS18175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_RS18180	COG2181	nitrate reductase activity
U712_RS18185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
U712_RS18190	COG1140	nitrate reductase beta subunit
U712_RS18195	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
U712_RS18200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U712_RS18210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U712_RS18215	COG2223	nitrite transmembrane transporter activity
U712_RS18220	COG0018	arginyl-trna synthetase
U712_RS18225	COG4506	Protein conserved in bacteria
U712_RS18235	COG0535	radical SAM domain protein
U712_RS18245	COG1131	(ABC) transporter
U712_RS18250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U712_RS18255	COG0612	Peptidase, M16
U712_RS18260	COG0612	Peptidase, M16
U712_RS18270	COG3391	amine dehydrogenase activity
U712_RS18275	COG3391	amine dehydrogenase activity
U712_RS18285	COG0457	Tetratricopeptide repeat
U712_RS18295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U712_RS18300	COG0010	Belongs to the arginase family
U712_RS18305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
U712_RS18310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_RS18320	COG1994	Peptidase M50
U712_RS18325	COG1942	4-Oxalocrotonate Tautomerase
U712_RS18330	COG1846	Transcriptional regulator
U712_RS18335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U712_RS18340	COG0477	Major facilitator Superfamily
U712_RS18345	COG1959	2 iron, 2 sulfur cluster binding
U712_RS18350	COG3465	dGTPase activity
U712_RS18355	COG1078	dGTPase activity
U712_RS18360	COG4844	belongs to the
U712_RS18370	COG0697	spore germination
U712_RS18375	COG0095	Lipoate-protein ligase
U712_RS18380	COG0583	DNA-binding transcription factor activity
U712_RS18385	COG0280	phosphate acetyltransferase
U712_RS18390	COG3253	May function as heme-dependent peroxidase
U712_RS18395	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS18400	COG0436	Aminotransferase
U712_RS18405	COG2814	Major facilitator Superfamily
U712_RS18410	COG0151	Belongs to the GarS family
U712_RS18415	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS18420	COG1917	Cupin 2, conserved barrel domain protein
U712_RS18425	COG0077	Prephenate dehydratase
U712_RS18430	COG2814	Major facilitator Superfamily
U712_RS18435	COG0833	amino acid
U712_RS18440	COG4187	Peptidase family M20/M25/M40
U712_RS18445	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS18450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_RS18460	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
U712_RS18465	COG1091	dTDP-4-dehydrorhamnose reductase activity
U712_RS18470	COG1088	dTDP-glucose 4,6-dehydratase activity
U712_RS18475	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
U712_RS18480	COG3980	spore coat polysaccharide biosynthesis protein
U712_RS18485	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
U712_RS18490	COG2089	acid synthase
U712_RS18495	COG0456	acetyltransferase
U712_RS18500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_RS18505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_RS18510	COG0463	Glycosyl transferase, family 2
U712_RS18525	COG2363	Small membrane protein
U712_RS18530	COG2233	PERMEase
U712_RS18540	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS18545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
U712_RS18550	COG1216	Glycosyl transferase, family 2
U712_RS18565	COG1695	Transcriptional regulator
U712_RS18570	COG0351	phosphomethylpyrimidine kinase
U712_RS18580	COG1621	beta-fructofuranosidase activity
U712_RS18585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS18585	COG1263	PTS System
U712_RS18590	COG2116	formate transmembrane transporter activity
U712_RS18595	COG3711	transcriptional antiterminator
U712_RS18605	COG1404	Belongs to the peptidase S8 family
U712_RS18610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS18615	COG0778	Nitroreductase
U712_RS18620	COG0772	Belongs to the SEDS family
U712_RS18630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U712_RS18635	COG1845	cytochrome c oxidase, subunit III
U712_RS18640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U712_RS18645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U712_RS18650	COG2261	transglycosylase associated protein
U712_RS18655	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
U712_RS18660	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
U712_RS18665	COG2246	polysaccharide biosynthetic process
U712_RS18670	COG1309	transcriptional regulator
U712_RS18680	COG3162	membrane
U712_RS18690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
U712_RS18695	COG2837	iron assimilation
U712_RS18700	COG2822	iron ion transport
U712_RS18705	COG0672	)-iron permease
U712_RS18710	COG0352	thiamine-phosphate diphosphorylase activity
U712_RS18715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
U712_RS18720	COG0583	DNA-binding transcription factor activity
U712_RS18725	COG1380	Effector of murein hydrolase LrgA
U712_RS18730	COG1346	cytolysis
U712_RS18735	COG2814	Major facilitator Superfamily
U712_RS18740	COG4895	conserved protein (DUF2196)
U712_RS18745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U712_RS18750	COG0346	lactoylglutathione lyase activity
U712_RS18760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_RS18765	COG1404	Belongs to the peptidase S8 family
U712_RS18770	COG1263	PTS System
U712_RS18770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS18775	COG3711	transcriptional antiterminator
U712_RS18780	COG1442	glycosyl transferase family 8
U712_RS18785	COG5522	Integral membrane protein (intg_mem_TP0381)
U712_RS18790	COG1846	Transcriptional regulator
U712_RS18795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U712_RS18800	COG2234	aminopeptidase activity
U712_RS18805	COG2357	RelA SpoT domain protein
U712_RS18810	COG1575	Belongs to the MenA family. Type 1 subfamily
U712_RS18820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_RS18825	COG1696	Membrane protein involved in D-alanine export
U712_RS18830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_RS18835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
U712_RS18840	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
U712_RS18845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_RS18850	COG1486	melibiose metabolic process
U712_RS18855	COG1447	Phosphotransferase system cellobiose-specific component IIA
U712_RS18860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_RS18865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_RS18870	COG3711	transcriptional antiterminator
U712_RS18870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_RS18875	COG2094	Belongs to the DNA glycosylase MPG family
U712_RS18880	COG0753	catalase activity
U712_RS18885	COG2814	Major facilitator Superfamily
U712_RS18890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_RS18895	COG1131	(ABC) transporter
U712_RS18915	COG1595	DNA-templated transcription, initiation
U712_RS18920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
U712_RS18925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U712_RS18930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
U712_RS18935	COG4988	ABC transporter
U712_RS18940	COG1294	oxidase, subunit
U712_RS18945	COG1271	oxidase subunit
U712_RS18950	COG3493	citrate carrier protein
U712_RS18955	COG0501	Belongs to the peptidase M48B family
U712_RS18965	COG0726	polysaccharide deacetylase
U712_RS18970	COG3842	ATPase activity
U712_RS18975	COG2508	Transcriptional regulator
U712_RS18980	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS18985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_RS18995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U712_RS19000	COG1881	PFAM PEBP family protein
U712_RS19005	COG0583	DNA-binding transcription factor activity
U712_RS19015	COG4585	Histidine kinase
U712_RS19020	COG2197	response regulator
U712_RS19025	COG2195	Cleaves the N-terminal amino acid of tripeptides
U712_RS19035	COG4894	glucomannan catabolic process
U712_RS19040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_RS19045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_RS19050	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS19055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U712_RS19060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U712_RS19065	COG2610	gluconate transmembrane transporter activity
U712_RS19070	COG0500	methyltransferase
U712_RS19075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_RS19095	COG0753	catalase activity
U712_RS19095	COG0693	protein deglycase activity
U712_RS19100	COG2851	Citrate transporter
U712_RS19105	COG2273	Hydrolase Family 16
U712_RS19110	COG3711	transcriptional antiterminator
U712_RS19120	COG2270	Major facilitator Superfamily
U712_RS19125	COG0513	Belongs to the DEAD box helicase family
U712_RS19130	COG2755	lipolytic protein G-D-S-L family
U712_RS19130	COG3401	FG-GAP repeat protein
U712_RS19180	COG3209	COG3209 Rhs family protein
U712_RS19185	COG0697	spore germination
U712_RS19190	COG0589	response to stress
U712_RS19195	COG2723	6-phospho-beta-galactosidase activity
U712_RS19200	COG1263	PTS System
U712_RS19200	COG2190	(PTS) system
U712_RS19200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_RS19215	COG5444	nuclease activity
U712_RS19230	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_RS19240	COG2986	histidine ammonia-lyase
U712_RS19245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
U712_RS19250	COG1228	amidohydrolase
U712_RS19255	COG0010	Belongs to the arginase family
U712_RS19260	COG0833	amino acid
U712_RS19265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
U712_RS19270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_RS19275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U712_RS19280	COG2390	Transcriptional regulator
U712_RS19290	COG3192	ethanolamine utilization protein
U712_RS19295	COG2079	MmgE PrpD family protein
U712_RS19300	COG1473	amidohydrolase
U712_RS19305	COG1126	abc transporter atp-binding protein
U712_RS19310	COG0765	amino acid transport
U712_RS19315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_RS19320	COG0456	acetyltransferase
U712_RS19325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_RS19335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
U712_RS19340	COG0561	phosphatase activity
U712_RS19370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_RS19375	COG5294	Protein conserved in bacteria
U712_RS19380	COG0577	efflux transmembrane transporter activity
U712_RS19385	COG1136	(ABC) transporter
U712_RS19390	COG2205	protein histidine kinase activity
U712_RS19395	COG0745	RESPONSE REGULATOR receiver
U712_RS19400	COG0191	fructose-bisphosphate aldolase activity
U712_RS19405	COG1082	Xylose isomerase domain protein TIM barrel
U712_RS19410	COG1082	Xylose isomerase domain protein TIM barrel
U712_RS19415	COG0673	inositol 2-dehydrogenase activity
U712_RS19420	COG2814	Major facilitator Superfamily
U712_RS19425	COG1082	Xylose isomerase domain protein TIM barrel
U712_RS19430	COG3962	Belongs to the TPP enzyme family
U712_RS19435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_RS19440	COG3718	enzyme involved in inositol metabolism
U712_RS19445	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS19450	COG1349	DNA-binding transcription factor activity
U712_RS19455	COG0667	Aldo Keto reductase
U712_RS19470	COG2814	Major facilitator Superfamily
U712_RS19475	COG0326	Molecular chaperone. Has ATPase activity
U712_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS19490	COG1309	transcriptional regulator
U712_RS19495	COG1012	belongs to the aldehyde dehydrogenase family
U712_RS19500	COG0456	acetyltransferase
U712_RS19505	COG2850	peptidyl-arginine hydroxylation
U712_RS19510	COG2226	methyltransferase
U712_RS19525	COG0367	asparagine synthase
U712_RS19530	COG2814	Major facilitator Superfamily
U712_RS19535	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U712_RS19545	COG1714	RDD family
U712_RS19550	COG2311	Membrane
U712_RS19555	COG1917	Cupin 2, conserved barrel domain protein
U712_RS19560	COG1309	transcriptional regulator
U712_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
U712_RS19570	COG1846	Transcriptional regulator
U712_RS19575	COG1380	Effector of murein hydrolase LrgA
U712_RS19580	COG1346	cytolysis
U712_RS19585	COG5039	Polysaccharide pyruvyl transferase
U712_RS19590	COG1929	Belongs to the glycerate kinase type-1 family
U712_RS19595	COG1802	Transcriptional regulator
U712_RS19600	COG1070	Carbohydrate kinase
U712_RS19605	COG2610	gluconate transmembrane transporter activity
U712_RS19610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U712_RS19615	COG0450	alkyl hydroperoxide reductase
U712_RS19620	COG3634	alkyl hydroperoxide reductase activity
U712_RS19625	COG2723	6-phospho-beta-galactosidase activity
U712_RS19630	COG2190	(PTS) system
U712_RS19635	COG2188	Transcriptional regulator
U712_RS19650	COG1131	(ABC) transporter
U712_RS19655	COG1994	Peptidase M50
U712_RS19660	COG0535	radical SAM domain protein
U712_RS19670	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
U712_RS19675	COG5293	efflux transmembrane transporter activity
U712_RS19685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U712_RS19690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
U712_RS19700	COG1063	alcohol dehydrogenase
U712_RS19720	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
U712_RS19725	COG0456	acetyltransferase
U712_RS19730	COG0457	Tetratricopeptide repeat
U712_RS19740	COG0010	Belongs to the arginase family
U712_RS19745	COG0833	amino acid
U712_RS19750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U712_RS19755	COG3829	transcription factor binding
U712_RS19760	COG5002	protein histidine kinase activity
U712_RS19765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_RS19770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
U712_RS19775	COG4853	Protein conserved in bacteria
U712_RS19780	COG4863	YycH protein
U712_RS19785	COG5002	protein histidine kinase activity
U712_RS19790	COG0745	RESPONSE REGULATOR receiver
U712_RS19820	COG0346	lactoylglutathione lyase activity
U712_RS19825	COG0305	Participates in initiation and elongation during chromosome replication
U712_RS19840	COG2807	transmembrane transport
U712_RS19845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U712_RS19850	COG0359	binds to the 23S rRNA
U712_RS19855	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
U712_RS19860	COG4241	membrane
U712_RS19870	COG5577	PFAM Coat F domain
U712_RS19875	COG1733	regulation of RNA biosynthetic process
U712_RS19880	COG1227	inorganic diphosphatase activity
U712_RS19895	COG2271	Major facilitator Superfamily
U712_RS19930	COG1131	(ABC) transporter
U712_RS19940	COG4319	ketosteroid isomerase
U712_RS19945	COG1357	PFAM Pentapeptide repeats (8 copies)
U712_RS19950	COG2814	Major facilitator Superfamily
U712_RS19955	COG0583	DNA-binding transcription factor activity
U712_RS19960	COG2153	protein acetylation
U712_RS19970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_RS19975	COG1846	Transcriptional regulator
U712_RS19980	COG2153	protein acetylation
U712_RS19985	COG2364	Membrane
U712_RS19990	COG0456	acetyltransferase
U712_RS19995	COG2315	Protein conserved in bacteria
U712_RS20000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_RS20005	COG2814	Major facilitator Superfamily
U712_RS20010	COG1331	Highly conserved protein containing a thioredoxin domain
U712_RS20015	COG0789	Transcriptional regulator
U712_RS20020	COG0697	spore germination
U712_RS20025	COG1331	Highly conserved protein containing a thioredoxin domain
U712_RS20030	COG1266	CAAX protease self-immunity
U712_RS20035	COG0477	Major facilitator Superfamily
U712_RS20035	COG2814	Major facilitator Superfamily
U712_RS20040	COG0110	maltose O-acetyltransferase activity
U712_RS20045	COG0346	lactoylglutathione lyase activity
U712_RS20050	COG1609	Transcriptional regulator
U712_RS20055	COG0708	Exodeoxyribonuclease III
U712_RS20060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
U712_RS20065	COG0629	single-stranded DNA binding
U712_RS20070	COG0360	Binds together with S18 to 16S ribosomal RNA
U712_RS20075	COG0012	GTP binding
U712_RS20080	COG0243	molybdopterin cofactor binding
U712_RS20085	COG4481	Protein conserved in bacteria
U712_RS20090	COG3949	Membrane
U712_RS20100	COG1475	DNA binding
U712_RS20105	COG1192	Involved in chromosome partitioning
U712_RS20115	COG1475	DNA binding
U712_RS20120	COG0357	Ribosomal RNA small subunit methyltransferase G
U712_RS20125	COG0445	tRNA wobble uridine modification
U712_RS20130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U712_RS20135	COG1847	R3H domain protein
U712_RS20140	COG0706	membrane insertase activity
U712_RS20145	COG0594	ribonuclease P activity