locus-tag	class	description
B657_RS00025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B657_RS00030	COG0592	DNA-directed DNA polymerase activity
B657_RS00035	COG2501	S4 domain
B657_RS00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B657_RS00050	COG0187	DNA topoisomerase II activity
B657_RS00055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B657_RS00090	COG0517	IMP dehydrogenase activity
B657_RS00090	COG0516	GMP reductase activity
B657_RS00095	COG1686	Belongs to the peptidase S11 family
B657_RS00100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B657_RS00105	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B657_RS00110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B657_RS00120	COG1428	Deoxynucleoside kinase
B657_RS00125	COG1428	Deoxynucleoside kinase
B657_RS00130	COG3858	chitin binding
B657_RS00130	COG1388	LysM domain
B657_RS00135	COG1335	isochorismatase
B657_RS00140	COG0590	tRNA wobble adenosine to inosine editing
B657_RS00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B657_RS00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B657_RS00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B657_RS00200	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B657_RS00205	COG3853	Toxic anion resistance protein (TelA)
B657_RS00210	COG1982	Orn Lys Arg decarboxylase major
B657_RS00215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B657_RS00220	COG3870	Protein conserved in bacteria
B657_RS00225	COG1728	Protein conserved in bacteria
B657_RS00230	COG0470	DNA polymerase III
B657_RS00235	COG1774	PSP1 C-terminal conserved region
B657_RS00240	COG4467	Involved in initiation control of chromosome replication
B657_RS00245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B657_RS00250	COG2827	Endonuclease containing a URI domain
B657_RS00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B657_RS00260	COG2002	toxin-antitoxin pair type II binding
B657_RS00265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_RS00265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_RS00270	COG0084	hydrolase, TatD family'
B657_RS00275	COG3584	3D domain protein
B657_RS00275	COG3583	domain protein
B657_RS00280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B657_RS00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B657_RS00295	COG4466	Protein conserved in bacteria
B657_RS00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B657_RS00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_RS00315	COG0251	oxidation-reduction process
B657_RS00320	COG2088	sporulation resulting in formation of a cellular spore
B657_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B657_RS00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B657_RS00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B657_RS00345	COG0193	aminoacyl-tRNA hydrolase activity
B657_RS00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B657_RS00360	COG2002	toxin-antitoxin pair type II binding
B657_RS00365	COG2244	polysaccharide biosynthetic process
B657_RS00370	COG3956	TIGRFAM MazG family protein
B657_RS00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B657_RS00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B657_RS00395	COG1098	S1 RNA binding domain
B657_RS00410	COG2208	phosphoserine phosphatase activity
B657_RS00415	COG2304	oxidoreductase activity
B657_RS00420	COG0515	serine threonine protein kinase
B657_RS00425	COG0037	tRNA processing
B657_RS00430	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B657_RS00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B657_RS00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B657_RS00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B657_RS00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B657_RS00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_RS00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B657_RS00465	COG0512	Glutamine amidotransferase of anthranilate synthase
B657_RS00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_RS00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B657_RS00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B657_RS00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B657_RS00490	COG1396	sequence-specific DNA binding
B657_RS00495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B657_RS00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B657_RS00585	COG4463	regulation of RNA biosynthetic process
B657_RS00590	COG3880	PFAM UvrB UvrC protein
B657_RS00595	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B657_RS00600	COG0542	response to heat
B657_RS00605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B657_RS00610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B657_RS00615	COG4956	integral membrane protein (PIN domain superfamily)
B657_RS00620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B657_RS00625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B657_RS00630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B657_RS00640	COG1045	serine acetyltransferase
B657_RS00645	COG0215	cysteine-tRNA ligase activity
B657_RS00650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B657_RS00655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B657_RS00660	COG3688	RNA-binding protein containing a PIN domain
B657_RS00665	COG1595	DNA-templated transcription, initiation
B657_RS00675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B657_RS00690	COG0081	regulation of translation
B657_RS00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B657_RS00705	COG2813	Specifically methylates the guanine in position
B657_RS00710	COG0085	RNA polymerase activity
B657_RS00715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B657_RS00720	COG1358	cellular component organization or biogenesis
B657_RS00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B657_RS00730	COG0049	tRNA binding
B657_RS00735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B657_RS00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B657_RS00745	COG0596	Alpha beta hydrolase
B657_RS00755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B657_RS00760	COG0088	Forms part of the polypeptide exit tunnel
B657_RS00770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B657_RS00785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B657_RS00790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B657_RS00800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B657_RS00805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B657_RS00815	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B657_RS00825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B657_RS00830	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B657_RS00835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B657_RS00840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B657_RS00850	COG0200	Binds to the 23S rRNA
B657_RS00855	COG0201	protein transport
B657_RS00860	COG0563	adenylate kinase activity
B657_RS00865	COG0024	Methionine aminopeptidase
B657_RS00870	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B657_RS00880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B657_RS00885	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B657_RS00890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B657_RS00895	COG0202	RNA polymerase activity
B657_RS00900	COG0203	ribosomal protein L17
B657_RS00905	COG1122	ATPase activity
B657_RS00910	COG1122	ATPase activity
B657_RS00915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B657_RS00920	COG0101	tRNA pseudouridine synthase activity
B657_RS00925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B657_RS00930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B657_RS00935	COG2226	methyltransferase
B657_RS00945	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS00950	COG0489	protein tyrosine kinase activity
B657_RS00960	COG2194	sulfuric ester hydrolase activity
B657_RS00965	COG0726	polysaccharide deacetylase
B657_RS01050	COG0659	secondary active sulfate transmembrane transporter activity
B657_RS01055	COG0385	Bile acid
B657_RS01060	COG2819	hydrolase of the alpha beta superfamily
B657_RS01065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS01075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS01080	COG2207	Transcriptional regulator
B657_RS01080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS01085	COG3876	Protein conserved in bacteria
B657_RS01090	COG1472	Belongs to the glycosyl hydrolase 3 family
B657_RS01095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_RS01100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS01100	COG1263	PTS System
B657_RS01105	COG1737	Transcriptional regulator
B657_RS01110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B657_RS01115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS01120	COG1683	Conserved Protein
B657_RS01150	COG1595	DNA-templated transcription, initiation
B657_RS01155	COG5662	AntiSigma factor
B657_RS01160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B657_RS01165	COG4856	YbbR-like protein
B657_RS01170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B657_RS01175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B657_RS01180	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B657_RS01185	COG2169	Transcriptional regulator
B657_RS01190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B657_RS01195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B657_RS01200	COG3002	Belongs to the UPF0753 family
B657_RS01205	COG0288	reversible hydration of carbon dioxide
B657_RS01215	COG5609	conserved protein (DUF2294)
B657_RS01225	COG0640	Transcriptional regulator
B657_RS01230	COG2814	Major facilitator Superfamily
B657_RS01235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B657_RS01245	COG0535	radical SAM domain protein
B657_RS01250	COG1266	CAAX protease self-immunity
B657_RS01255	COG1131	(ABC) transporter
B657_RS01265	COG1413	lyase activity
B657_RS01270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS01275	COG0596	Alpha beta hydrolase
B657_RS01280	COG0745	RESPONSE REGULATOR receiver
B657_RS01295	COG0515	serine threonine protein kinase
B657_RS01310	COG1113	amino acid transport
B657_RS01325	COG2602	Beta-lactamase
B657_RS01330	COG2124	cytochrome p450
B657_RS01340	COG0531	amino acid
B657_RS01345	COG0584	glycerophosphoryl diester phosphodiesterase
B657_RS01350	COG2271	Major facilitator Superfamily
B657_RS01360	COG0456	acetyltransferase
B657_RS01360	COG1846	Transcriptional regulator
B657_RS01365	COG2271	Major facilitator Superfamily
B657_RS01380	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS01385	COG0697	spore germination
B657_RS01390	COG1917	Cupin 2, conserved barrel domain protein
B657_RS01390	COG2207	Transcriptional regulator
B657_RS01395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B657_RS01400	COG3591	Belongs to the peptidase S1B family
B657_RS01410	COG0596	Alpha beta hydrolase
B657_RS01415	COG1183	phosphatidylcholine synthase activity
B657_RS01420	COG0586	Pfam SNARE associated Golgi protein
B657_RS01425	COG0688	phosphatidylethanolamine metabolic process
B657_RS01435	COG2312	Erythromycin esterase
B657_RS01440	COG2207	Transcriptional regulator
B657_RS01445	COG1054	Belongs to the UPF0176 family
B657_RS01450	COG1301	dicarboxylic acid transport
B657_RS01455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS01455	COG1263	PTS System
B657_RS01455	COG2190	(PTS) system
B657_RS01460	COG0363	glucosamine-6-phosphate deaminase activity
B657_RS01465	COG2188	Transcriptional regulator
B657_RS01475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_RS01480	COG0833	amino acid
B657_RS01485	COG2040	homocysteine
B657_RS01495	COG1115	amino acid carrier protein
B657_RS01500	COG2066	Belongs to the glutaminase family
B657_RS01505	COG4191	Histidine kinase
B657_RS01510	COG0784	Response regulator, receiver
B657_RS01515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B657_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS01525	COG2271	Major facilitator Superfamily
B657_RS01530	COG4948	Mandelate Racemase Muconate Lactonizing
B657_RS01535	COG2186	Transcriptional regulator
B657_RS01540	COG2721	sulfolactate sulfo-lyase activity
B657_RS01545	COG3173	Aminoglycoside phosphotransferase
B657_RS01555	COG0697	spore germination
B657_RS01560	COG0745	RESPONSE REGULATOR receiver
B657_RS01565	COG2205	protein histidine kinase activity
B657_RS01570	COG1131	(ABC) transporter
B657_RS01590	COG3773	Cell wall hydrolase
B657_RS01595	COG2304	oxidoreductase activity
B657_RS01605	COG3540	Alkaline phosphatase
B657_RS01610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_RS01615	COG0805	protein transport
B657_RS01620	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B657_RS01625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B657_RS01630	COG0477	Major facilitator Superfamily
B657_RS01635	COG1309	transcriptional regulator
B657_RS01640	COG0252	asparaginase activity
B657_RS01645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B657_RS01650	COG1714	RDD family
B657_RS01655	COG3012	SEC-C Motif Domain Protein
B657_RS01655	COG1405	negative regulation of cell septum assembly
B657_RS01660	COG3290	protein histidine kinase activity
B657_RS01665	COG3279	Response regulator of the LytR AlgR family
B657_RS01670	COG4555	ABC transporter
B657_RS01675	COG1668	transmembrane transport
B657_RS01680	COG0667	Aldo Keto reductase
B657_RS01690	COG1595	DNA-templated transcription, initiation
B657_RS01695	COG1595	DNA-templated transcription, initiation
B657_RS01700	COG1876	peptidase activity
B657_RS01705	COG0457	Tetratricopeptide repeat
B657_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS01715	COG0366	Alpha amylase catalytic
B657_RS01720	COG0803	Belongs to the bacterial solute-binding protein 9 family
B657_RS01725	COG1121	(ABC) transporter
B657_RS01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_RS01735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS01740	COG2310	stress, protein
B657_RS01745	COG2310	stress, protein
B657_RS01750	COG2310	stress, protein
B657_RS01755	COG0861	Integral membrane protein TerC family
B657_RS01765	COG3853	Toxic anion resistance protein (TelA)
B657_RS01770	COG0477	Major facilitator Superfamily
B657_RS01775	COG2814	Major facilitator Superfamily
B657_RS01780	COG0640	Transcriptional regulator
B657_RS01785	COG0517	IMP dehydrogenase activity
B657_RS01785	COG4175	Glycine betaine
B657_RS01790	COG4176	ABC-type proline glycine betaine transport system permease component
B657_RS01795	COG2113	Glycine betaine
B657_RS01800	COG1473	amidohydrolase
B657_RS01805	COG1288	antiporter activity
B657_RS01820	COG0366	Alpha amylase catalytic
B657_RS01825	COG0039	L-malate dehydrogenase activity
B657_RS01830	COG1620	l-lactate permease
B657_RS01835	COG2814	Major facilitator Superfamily
B657_RS01840	COG1846	Transcriptional regulator
B657_RS01845	COG1280	lysine exporter protein (LysE YggA)
B657_RS01850	COG3403	YqcI/YcgG family
B657_RS01855	COG1113	amino acid transport
B657_RS01860	COG3665	Urea carboxylase-associated protein
B657_RS01865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B657_RS01870	COG1660	Displays ATPase and GTPase activities
B657_RS01880	COG2226	methyltransferase
B657_RS01885	COG0583	DNA-binding transcription factor activity
B657_RS01890	COG3458	cephalosporin-C deacetylase activity
B657_RS01895	COG3541	Predicted nucleotidyltransferase
B657_RS01900	COG0506	proline dehydrogenase activity
B657_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS01910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_RS01915	COG2508	Transcriptional regulator
B657_RS01920	COG3689	TIGRFAM TIGR03943 family protein
B657_RS01925	COG0701	Predicted permease
B657_RS01930	COG2267	carboxylic ester hydrolase activity
B657_RS01935	COG0492	ferredoxin-NADP+ reductase activity
B657_RS01940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B657_RS01940	COG1587	Uroporphyrinogen-III synthase
B657_RS01945	COG2146	nitrite reductase [NAD(P)H] activity
B657_RS01950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_RS01955	COG0243	molybdopterin cofactor binding
B657_RS01960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_RS01965	COG2223	nitrite transmembrane transporter activity
B657_RS01970	COG1469	GTP cyclohydrolase I activity
B657_RS01975	COG1376	ErfK ybiS ycfS ynhG family protein
B657_RS01985	COG0523	cobalamin synthesis protein
B657_RS01990	COG0765	amino acid transport
B657_RS01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS02005	COG1714	RDD family
B657_RS02015	COG2723	6-phospho-beta-galactosidase activity
B657_RS02025	COG3209	COG3209 Rhs family protein
B657_RS02030	COG0840	transmembrane signaling receptor activity
B657_RS02030	COG3290	protein histidine kinase activity
B657_RS02035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B657_RS02040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B657_RS02045	COG1733	regulation of RNA biosynthetic process
B657_RS02055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS02060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS02065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS02070	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B657_RS02075	COG2814	Major facilitator Superfamily
B657_RS02085	COG0697	spore germination
B657_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS02100	COG2364	Membrane
B657_RS02105	COG1126	abc transporter atp-binding protein
B657_RS02110	COG0765	amino acid transport
B657_RS02115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS02120	COG0583	DNA-binding transcription factor activity
B657_RS02125	COG0163	prenyltransferase activity
B657_RS02130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B657_RS02145	COG0596	Alpha beta hydrolase
B657_RS02150	COG3104	oligopeptide transport
B657_RS02155	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_RS02165	COG0697	spore germination
B657_RS02175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B657_RS02180	COG1136	(ABC) transporter
B657_RS02185	COG0577	efflux transmembrane transporter activity
B657_RS02190	COG0745	RESPONSE REGULATOR receiver
B657_RS02195	COG5002	protein histidine kinase activity
B657_RS02195	COG3850	Histidine kinase
B657_RS02200	COG0457	Tetratricopeptide repeat
B657_RS02220	COG0527	aspartate kinase activity
B657_RS02225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS02230	COG4605	iron ion homeostasis
B657_RS02235	COG4604	ABC transporter, ATP-binding protein
B657_RS02240	COG4607	ABC-type enterochelin transport system periplasmic component
B657_RS02245	COG2814	Major facilitator Superfamily
B657_RS02250	COG1309	transcriptional regulator
B657_RS02255	COG0778	Nitroreductase
B657_RS02260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B657_RS02265	COG0640	Transcriptional regulator
B657_RS02270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS02275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B657_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS02285	COG4975	Glucose uptake
B657_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS02295	COG4549	nuclear export factor GLE1
B657_RS02300	COG1276	copper resistance
B657_RS02300	COG2372	response to copper ion
B657_RS02305	COG1349	DNA-binding transcription factor activity
B657_RS02315	COG2213	PTS system mannitol-specific
B657_RS02320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS02325	COG0246	Mannitol dehydrogenase
B657_RS02330	COG0473	3-isopropylmalate dehydrogenase activity
B657_RS02335	COG0681	Belongs to the peptidase S26 family
B657_RS02345	COG0412	Dienelactone hydrolase
B657_RS02350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B657_RS02360	COG0561	phosphatase activity
B657_RS02365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B657_RS02370	COG1914	H( )-stimulated, divalent metal cation uptake system
B657_RS02375	COG4336	lyase activity
B657_RS02380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B657_RS02385	COG1984	allophanate hydrolase subunit 2
B657_RS02390	COG1414	Transcriptional regulator
B657_RS02395	COG2755	lipolytic protein G-D-S-L family
B657_RS02405	COG2329	Antibiotic biosynthesis monooxygenase
B657_RS02410	COG0768	penicillin binding
B657_RS02415	COG4989	oxidoreductase activity
B657_RS02420	COG3711	transcriptional antiterminator
B657_RS02425	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS02430	COG2226	methyltransferase
B657_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS02440	COG1917	Cupin 2, conserved barrel domain protein
B657_RS02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS02450	COG3871	stress protein (general stress protein 26)
B657_RS02460	COG2814	Major facilitator Superfamily
B657_RS02465	COG1522	sequence-specific DNA binding
B657_RS02470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B657_RS02470	COG0551	DNA topoisomerase type I activity
B657_RS02475	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B657_RS02480	COG3706	GGDEF domain
B657_RS02485	COG5298	Protein conserved in bacteria
B657_RS02490	COG1215	transferase activity, transferring glycosyl groups
B657_RS02500	COG0531	amino acid
B657_RS02505	COG0494	nUDIX hydrolase
B657_RS02510	COG0028	Belongs to the TPP enzyme family
B657_RS02525	COG1914	H( )-stimulated, divalent metal cation uptake system
B657_RS02530	COG2261	transglycosylase associated protein
B657_RS02535	COG4876	unkown
B657_RS02540	COG2217	Heavy metal translocating P-type atpase
B657_RS02545	COG3729	General stress protein
B657_RS02550	COG0662	Cupin 2, conserved barrel domain protein
B657_RS02555	COG2329	Antibiotic biosynthesis monooxygenase
B657_RS02560	COG3546	catalase activity
B657_RS02565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B657_RS02570	COG3290	protein histidine kinase activity
B657_RS02575	COG4565	transcriptional regulatory protein
B657_RS02580	COG1301	dicarboxylic acid transport
B657_RS02585	COG0628	permease
B657_RS02595	COG1131	(ABC) transporter
B657_RS02600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_RS02610	COG1960	acyl-CoA dehydrogenase activity
B657_RS02625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_RS02630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS02635	COG1181	Belongs to the D-alanine--D-alanine ligase family
B657_RS02640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B657_RS02645	COG0513	Belongs to the DEAD box helicase family
B657_RS02650	COG3402	PFAM membrane-flanked domain
B657_RS02655	COG3428	Bacterial PH domain
B657_RS02660	COG0705	Rhomboid family
B657_RS02665	COG0736	holo-[acyl-carrier-protein] synthase activity
B657_RS02670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B657_RS02680	COG0864	Transcriptional regulator
B657_RS02685	COG2337	Toxic component of a toxin-antitoxin (TA) module
B657_RS02690	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS02695	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS02700	COG2172	sigma factor antagonist activity
B657_RS02705	COG2208	phosphoserine phosphatase activity
B657_RS02710	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS02715	COG2172	sigma factor antagonist activity
B657_RS02720	COG1191	sigma factor activity
B657_RS02725	COG2208	phosphoserine phosphatase activity
B657_RS02740	COG1673	EVE domain
B657_RS02745	COG1846	Transcriptional regulator
B657_RS02750	COG2183	response to ionizing radiation
B657_RS02760	COG3091	SprT-like family
B657_RS02800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS02805	COG1522	sequence-specific DNA binding
B657_RS02810	COG1522	sequence-specific DNA binding
B657_RS02815	COG1335	isochorismatase
B657_RS02820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B657_RS02825	COG2814	Major facilitator Superfamily
B657_RS02845	COG0693	protein deglycase activity
B657_RS02850	COG1278	Cold shock
B657_RS02855	COG1329	Transcriptional regulator
B657_RS02860	COG0697	spore germination
B657_RS02865	COG2207	Transcriptional regulator
B657_RS02865	COG1917	Cupin 2, conserved barrel domain protein
B657_RS02870	COG0697	spore germination
B657_RS02875	COG3708	Transcriptional regulator
B657_RS02875	COG2207	Transcriptional regulator
B657_RS02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS02885	COG0477	Major facilitator Superfamily
B657_RS02895	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B657_RS02905	COG0697	spore germination
B657_RS02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS02915	COG2030	dehydratase
B657_RS02920	COG3545	Serine hydrolase
B657_RS02925	COG1733	regulation of RNA biosynthetic process
B657_RS02930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS02935	COG1733	regulation of RNA biosynthetic process
B657_RS02940	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_RS02945	COG2814	Major facilitator Superfamily
B657_RS02950	COG1309	transcriptional regulator
B657_RS02960	COG0640	Transcriptional regulator
B657_RS02965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B657_RS02975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS02980	COG0697	spore germination
B657_RS02985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS02990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B657_RS02995	COG0640	Transcriptional regulator
B657_RS03000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B657_RS03015	COG4585	Histidine kinase
B657_RS03020	COG2197	response regulator
B657_RS03025	COG2409	Drug exporters of the RND superfamily
B657_RS03030	COG0596	Alpha beta hydrolase
B657_RS03035	COG1811	Na channel or pump
B657_RS03040	COG0789	Transcriptional regulator
B657_RS03040	COG4978	Transcriptional regulator
B657_RS03045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_RS03050	COG0778	Nitroreductase
B657_RS03055	COG0346	lactoylglutathione lyase activity
B657_RS03060	COG2259	Doxx family
B657_RS03065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS03085	COG2323	membrane
B657_RS03090	COG2323	membrane
B657_RS03095	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_RS03110	COG1309	transcriptional regulator
B657_RS03120	COG0456	acetyltransferase
B657_RS03125	COG0488	(ABC) transporter
B657_RS03130	COG1113	amino acid transport
B657_RS03135	COG2318	DinB family
B657_RS03140	COG1846	Transcriptional regulator
B657_RS03145	COG1033	growth of symbiont in host cell
B657_RS03145	COG2409	Drug exporters of the RND superfamily
B657_RS03150	COG0778	Nitroreductase
B657_RS03155	COG1846	Transcriptional regulator
B657_RS03160	COG2814	Major facilitator Superfamily
B657_RS03165	COG0730	response to heat
B657_RS03170	COG1802	Transcriptional regulator
B657_RS03175	COG3858	chitin binding
B657_RS03175	COG1388	LysM domain
B657_RS03180	COG1819	glycosyl
B657_RS03190	COG1785	Belongs to the alkaline phosphatase family
B657_RS03195	COG5646	InterPro IPR014922
B657_RS03205	COG0454	-acetyltransferase
B657_RS03210	COG1078	dGTPase activity
B657_RS03215	COG1388	LysM domain
B657_RS03220	COG2814	Major facilitator Superfamily
B657_RS03225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_RS03230	COG1447	Phosphotransferase system cellobiose-specific component IIA
B657_RS03235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_RS03240	COG2723	6-phospho-beta-galactosidase activity
B657_RS03245	COG2188	Transcriptional regulator
B657_RS03250	COG1940	carbohydrate kinase activity
B657_RS03255	COG1482	cell wall glycoprotein biosynthetic process
B657_RS03260	COG4124	Belongs to the glycosyl hydrolase 26 family
B657_RS03310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B657_RS03315	COG0802	atpase or kinase
B657_RS03320	COG1214	PFAM Peptidase M22, glycoprotease
B657_RS03325	COG0456	acetyltransferase
B657_RS03330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B657_RS03335	COG0488	(ABC) transporter
B657_RS03340	COG0315	cyclic pyranopterin monophosphate synthase activity
B657_RS03345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B657_RS03350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_RS03355	COG0805	protein transport
B657_RS03365	COG1266	CAAX protease self-immunity
B657_RS03375	COG0459	protein refolding
B657_RS03390	COG3378	Phage plasmid primase P4 family
B657_RS03405	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_RS03410	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_RS03415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B657_RS03435	COG1401	restriction endodeoxyribonuclease activity
B657_RS03450	COG1073	alpha beta
B657_RS03455	COG0457	Tetratricopeptide repeat
B657_RS03460	COG1063	alcohol dehydrogenase
B657_RS03465	COG2211	Major facilitator Superfamily
B657_RS03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_RS03475	COG1842	Phage shock protein A
B657_RS03480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B657_RS03485	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B657_RS03490	COG4260	virion core protein, lumpy skin disease virus
B657_RS03500	COG2814	Major facilitator Superfamily
B657_RS03505	COG1063	alcohol dehydrogenase
B657_RS03510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B657_RS03515	COG0823	Involved in the tonB-independent uptake of proteins
B657_RS03530	COG2267	carboxylic ester hydrolase activity
B657_RS03540	COG2132	Multicopper oxidase
B657_RS03545	COG1113	amino acid transport
B657_RS03555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_RS03560	COG0714	Associated with various cellular activities
B657_RS03565	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B657_RS03570	COG1305	Transglutaminase-like
B657_RS03575	COG0519	Catalyzes the synthesis of GMP from XMP
B657_RS03575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B657_RS03580	COG2252	PERMEase
B657_RS03585	COG3064	Membrane
B657_RS03595	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B657_RS03605	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B657_RS03610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B657_RS03615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B657_RS03620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B657_RS03625	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B657_RS03630	COG0047	phosphoribosylformylglycinamidine synthase activity
B657_RS03635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B657_RS03640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B657_RS03645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B657_RS03650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B657_RS03655	COG0138	bifunctional purine biosynthesis protein purh
B657_RS03660	COG0151	Belongs to the GarS family
B657_RS03665	COG1522	sequence-specific DNA binding
B657_RS03670	COG0531	amino acid
B657_RS03680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B657_RS03685	COG1470	cell adhesion involved in biofilm formation
B657_RS03690	COG4496	protein, YerC YecD
B657_RS03695	COG0069	glutamate synthase activity
B657_RS03705	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B657_RS03710	COG0210	DNA helicase
B657_RS03715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B657_RS03720	COG4851	CamS sex pheromone cAM373 precursor
B657_RS03725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_RS03730	COG1285	pathogenesis
B657_RS03735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_RS03740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B657_RS03745	COG0154	amidase activity
B657_RS03750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B657_RS03755	COG1309	transcriptional regulator
B657_RS03760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B657_RS03765	COG1597	lipid kinase activity
B657_RS03770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B657_RS03775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_RS03780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_RS03785	COG1002	Type II restriction enzyme, methylase subunits
B657_RS03790	COG1061	Type III restriction enzyme res subunit
B657_RS03795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B657_RS03815	COG5444	nuclease activity
B657_RS03820	COG3391	amine dehydrogenase activity
B657_RS03825	COG0457	Tetratricopeptide repeat
B657_RS03835	COG0217	transcriptional regulatory protein
B657_RS03845	COG1309	transcriptional regulator
B657_RS03850	COG3631	Ketosteroid isomerase-related protein
B657_RS03855	COG0702	epimerase
B657_RS03870	COG3546	catalase activity
B657_RS03875	COG0454	-acetyltransferase
B657_RS03885	COG5578	integral membrane protein
B657_RS03890	COG2972	Histidine kinase
B657_RS03895	COG2207	Transcriptional regulator
B657_RS03895	COG4753	response regulator
B657_RS03900	COG1653	transport
B657_RS03905	COG1175	transmembrane transport
B657_RS03910	COG0395	ABC-type sugar transport system, permease component
B657_RS03915	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B657_RS03920	COG2207	Transcriptional regulator
B657_RS03925	COG2755	lipolytic protein G-D-S-L family
B657_RS03935	COG5578	integral membrane protein
B657_RS03940	COG3401	FG-GAP repeat protein
B657_RS03945	COG3401	FG-GAP repeat protein
B657_RS03955	COG1874	Beta-galactosidase
B657_RS03965	COG1653	transport
B657_RS03970	COG4209	transmembrane transport
B657_RS03975	COG0395	ABC-type sugar transport system, permease component
B657_RS03980	COG1486	melibiose metabolic process
B657_RS03985	COG2323	membrane
B657_RS03990	COG2329	Antibiotic biosynthesis monooxygenase
B657_RS03995	COG0346	lactoylglutathione lyase activity
B657_RS04010	COG5583	Uncharacterized small protein (DUF2292)
B657_RS04015	COG0670	Belongs to the BI1 family
B657_RS04020	COG0697	spore germination
B657_RS04025	COG1846	Transcriptional regulator
B657_RS04030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B657_RS04040	COG2124	cytochrome p450
B657_RS04040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_RS04045	COG1368	sulfuric ester hydrolase activity
B657_RS04050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B657_RS04055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_RS04060	COG1442	glycosyl transferase family 8
B657_RS04065	COG1216	Glycosyl transferase, family 2
B657_RS04070	COG1442	glycosyl transferase family 8
B657_RS04075	COG2223	nitrite transmembrane transporter activity
B657_RS04080	COG1011	Hydrolase
B657_RS04085	COG0531	amino acid
B657_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS04095	COG0840	transmembrane signaling receptor activity
B657_RS04100	COG0488	(ABC) transporter
B657_RS04110	COG0789	Transcriptional regulator
B657_RS04115	COG2814	Major facilitator Superfamily
B657_RS04130	COG0488	(ABC) transporter
B657_RS04135	COG0513	Belongs to the DEAD box helicase family
B657_RS04140	COG0456	acetyltransferase
B657_RS04145	COG2130	NADP-dependent
B657_RS04160	COG2211	Major facilitator Superfamily
B657_RS04165	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B657_RS04170	COG1120	ATPase activity
B657_RS04175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS04180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS04185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B657_RS04200	COG3866	Pectate lyase
B657_RS04205	COG0471	metal ion transport
B657_RS04210	COG3290	protein histidine kinase activity
B657_RS04215	COG4565	transcriptional regulatory protein
B657_RS04220	COG3181	Tripartite tricarboxylate transporter family receptor
B657_RS04230	COG2851	Citrate transporter
B657_RS04235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS04240	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B657_RS04245	COG1254	Belongs to the acylphosphatase family
B657_RS04250	COG2258	MOSC domain
B657_RS04270	COG0024	Methionine aminopeptidase
B657_RS04275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS04275	COG1263	PTS System
B657_RS04280	COG1368	sulfuric ester hydrolase activity
B657_RS04290	COG1115	amino acid carrier protein
B657_RS04295	COG0531	amino acid
B657_RS04310	COG0697	spore germination
B657_RS04315	COG1263	PTS System
B657_RS04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS04320	COG0366	Alpha amylase catalytic
B657_RS04325	COG2188	Transcriptional regulator
B657_RS04330	COG0778	Nitroreductase
B657_RS04335	COG0737	Belongs to the 5'-nucleotidase family
B657_RS04340	COG0693	protein deglycase activity
B657_RS04345	COG2814	Major facilitator Superfamily
B657_RS04350	COG4840	Belongs to the UPF0435 family
B657_RS04355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B657_RS04360	COG4980	gas vesicle protein
B657_RS04365	COG1295	ribonuclease BN
B657_RS04375	COG0477	Major facilitator Superfamily
B657_RS04385	COG0387	Pfam Sodium calcium exchanger
B657_RS04395	COG0668	transmembrane transport
B657_RS04400	COG0535	radical SAM domain protein
B657_RS04410	COG0726	polysaccharide deacetylase
B657_RS04415	COG2084	Dehydrogenase
B657_RS04420	COG0598	Magnesium transport protein CorA
B657_RS04425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B657_RS04430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B657_RS04440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B657_RS04445	COG4637	Psort location Cytoplasmic, score
B657_RS04455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_RS04460	COG0022	dehydrogenase e1 component
B657_RS04465	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_RS04470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_RS04475	COG3284	Transcriptional regulator
B657_RS04485	COG1742	UPF0060 membrane protein
B657_RS04510	COG4842	Belongs to the WXG100 family
B657_RS04515	COG1486	melibiose metabolic process
B657_RS04520	COG1737	Transcriptional regulator
B657_RS04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS04525	COG1263	PTS System
B657_RS04530	COG1132	(ABC) transporter
B657_RS04535	COG1132	(ABC) transporter
B657_RS04540	COG2259	Doxx family
B657_RS04545	COG2514	catechol 2,3-dioxygenase activity
B657_RS04550	COG4977	sequence-specific DNA binding
B657_RS04550	COG1917	Cupin 2, conserved barrel domain protein
B657_RS04555	COG2814	Major facilitator Superfamily
B657_RS04560	COG1082	Xylose isomerase domain protein TIM barrel
B657_RS04565	COG0673	inositol 2-dehydrogenase activity
B657_RS04570	COG4585	Histidine kinase
B657_RS04575	COG2197	response regulator
B657_RS04580	COG1131	(ABC) transporter
B657_RS04585	COG1511	domain protein
B657_RS04585	COG0842	Transport permease protein
B657_RS04590	COG0842	Transport permease protein
B657_RS04595	COG1695	Transcriptional regulator
B657_RS04600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B657_RS04605	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B657_RS04610	COG1309	transcriptional regulator
B657_RS04615	COG2814	Major facilitator Superfamily
B657_RS04620	COG2318	DinB family
B657_RS04625	COG2814	Major facilitator Superfamily
B657_RS04630	COG1846	Transcriptional regulator
B657_RS04635	COG0392	lysyltransferase activity
B657_RS04635	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B657_RS04640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS04645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS04650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS04655	COG0384	phenazine biosynthesis protein PhzF
B657_RS04660	COG0778	Nitroreductase
B657_RS04675	COG1090	epimerase
B657_RS04680	COG2137	regulation of response to DNA damage stimulus
B657_RS04695	COG2814	Major facilitator Superfamily
B657_RS04710	COG3103	Sh3 type 3 domain protein
B657_RS04715	COG5658	integral membrane protein
B657_RS04720	COG0596	Alpha beta hydrolase
B657_RS04725	COG0463	Glycosyl transferase, family 2
B657_RS04730	COG4485	Bacterial membrane protein, YfhO
B657_RS04735	COG1988	membrane-bound metal-dependent
B657_RS04740	COG1194	a g-specific adenine glycosylase
B657_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS04765	COG3557	Belongs to the UPF0374 family
B657_RS04770	COG1132	(ABC) transporter
B657_RS04775	COG4129	membrane
B657_RS04780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B657_RS04785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B657_RS04790	COG0735	belongs to the Fur family
B657_RS04905	COG4326	sporulation control protein
B657_RS04915	COG5577	PFAM Coat F domain
B657_RS04920	COG3340	Belongs to the peptidase S51 family
B657_RS04925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B657_RS04930	COG0277	FAD linked oxidase domain protein
B657_RS04940	COG0753	catalase activity
B657_RS04945	COG1116	anion transmembrane transporter activity
B657_RS04950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B657_RS04955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B657_RS04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS04970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B657_RS04980	COG1476	TRANSCRIPTIONal
B657_RS04990	COG3382	B3 4 domain protein
B657_RS04995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B657_RS05005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B657_RS05010	COG0789	Transcriptional regulator
B657_RS05015	COG1664	Polymer-forming cytoskeletal
B657_RS05020	COG1664	Polymer-forming cytoskeletal
B657_RS05025	COG2766	serine protein kinase
B657_RS05030	COG2718	Belongs to the UPF0229 family
B657_RS05040	COG1846	Transcriptional regulator
B657_RS05045	COG1566	PFAM secretion protein HlyD family protein
B657_RS05050	COG2814	Major facilitator Superfamily
B657_RS05055	COG0655	NAD(P)H dehydrogenase (quinone) activity
B657_RS05070	COG1725	Transcriptional regulator
B657_RS05075	COG1131	(ABC) transporter
B657_RS05080	COG1131	(ABC) transporter
B657_RS05085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_RS05090	COG1278	Cold shock
B657_RS05100	COG1464	Belongs to the NlpA lipoprotein family
B657_RS05105	COG3706	GGDEF domain
B657_RS05110	COG1823	symporter activity
B657_RS05130	COG5577	PFAM Coat F domain
B657_RS05135	COG4085	toxin activity
B657_RS05135	COG1525	nuclease
B657_RS05135	COG0737	Belongs to the 5'-nucleotidase family
B657_RS05140	COG3764	Sortase (surface protein transpeptidase)
B657_RS05145	COG0564	pseudouridine synthase activity
B657_RS05155	COG0517	IMP dehydrogenase activity
B657_RS05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B657_RS05165	COG3153	acetyltransferase
B657_RS05165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B657_RS05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_RS05175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B657_RS05180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B657_RS05185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B657_RS05190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B657_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B657_RS05200	COG2203	Gaf domain
B657_RS05200	COG4585	Histidine kinase
B657_RS05205	COG2197	response regulator
B657_RS05210	COG0431	NADPH-dependent FMN reductase
B657_RS05225	COG0791	NLP P60 protein
B657_RS05225	COG1388	LysM domain
B657_RS05230	COG1959	2 iron, 2 sulfur cluster binding
B657_RS05235	COG0668	transmembrane transport
B657_RS05240	COG2719	SpoVR family
B657_RS05245	COG1785	Belongs to the alkaline phosphatase family
B657_RS05250	COG1388	LysM domain
B657_RS05250	COG0791	NLP P60 protein
B657_RS05255	COG0583	DNA-binding transcription factor activity
B657_RS05260	COG0372	Belongs to the citrate synthase family
B657_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS05270	COG0531	amino acid
B657_RS05275	COG0733	neurotransmitter:sodium symporter activity
B657_RS05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS05285	COG0456	acetyltransferase
B657_RS05300	COG1595	DNA-templated transcription, initiation
B657_RS05305	COG0667	Aldo Keto reductase
B657_RS05310	COG0204	Acyl-transferase
B657_RS05315	COG1253	flavin adenine dinucleotide binding
B657_RS05320	COG0789	Transcriptional regulator
B657_RS05325	COG0436	Aminotransferase
B657_RS05330	COG1253	flavin adenine dinucleotide binding
B657_RS05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B657_RS05340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B657_RS05345	COG0584	glycerophosphoryl diester phosphodiesterase
B657_RS05355	COG0668	transmembrane transport
B657_RS05360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B657_RS05365	COG0726	polysaccharide deacetylase
B657_RS05370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_RS05375	COG1757	Na H antiporter
B657_RS05380	COG0589	response to stress
B657_RS05390	COG1132	(ABC) transporter
B657_RS05400	COG0702	epimerase
B657_RS05415	COG0189	ligase activity
B657_RS05420	COG0189	ligase activity
B657_RS05425	COG4399	Belongs to the UPF0754 family
B657_RS05430	COG3679	Belongs to the UPF0342 family
B657_RS05435	COG4335	DNA alkylation repair
B657_RS05440	COG0561	phosphatase activity
B657_RS05445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B657_RS05450	COG0475	glutathione-regulated potassium exporter activity
B657_RS05455	COG0490	domain, Protein
B657_RS05465	COG1024	Enoyl-CoA hydratase
B657_RS05475	COG4152	abc transporter atp-binding protein
B657_RS05480	COG1668	transmembrane transport
B657_RS05485	COG0420	3'-5' exonuclease activity
B657_RS05490	COG4717	serine-type aminopeptidase activity
B657_RS05495	COG3481	metal-dependent phosphohydrolase, HD sub domain
B657_RS05505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B657_RS05530	COG1846	Transcriptional regulator
B657_RS05535	COG4980	gas vesicle protein
B657_RS05550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B657_RS05555	COG0537	adenosine 5'-monophosphoramidase activity
B657_RS05560	COG1131	(ABC) transporter
B657_RS05565	COG4473	ABC transporter
B657_RS05575	COG1473	amidohydrolase
B657_RS05580	COG3069	C4-dicarboxylate transmembrane transporter activity
B657_RS05590	COG2329	Antibiotic biosynthesis monooxygenase
B657_RS05595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_RS05600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B657_RS05605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B657_RS05610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B657_RS05615	COG1309	transcriptional regulator
B657_RS05620	COG1511	domain protein
B657_RS05625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_RS05630	COG4377	Putative membrane peptidase family (DUF2324)
B657_RS05640	COG1363	Peptidase, m42
B657_RS05645	COG4405	Protein conserved in bacteria
B657_RS05650	COG1301	dicarboxylic acid transport
B657_RS05660	COG1234	tRNA 3'-trailer cleavage
B657_RS05665	COG0095	Lipoate-protein ligase
B657_RS05670	COG0702	epimerase
B657_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS05685	COG0501	Belongs to the peptidase M48B family
B657_RS05690	COG1404	Belongs to the peptidase S8 family
B657_RS05695	COG0456	acetyltransferase
B657_RS05700	COG0604	alcohol dehydrogenase
B657_RS05705	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B657_RS05710	COG0406	alpha-ribazole phosphatase activity
B657_RS05715	COG0183	Belongs to the thiolase family
B657_RS05720	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS05725	COG1268	BioY protein
B657_RS05730	COG0840	transmembrane signaling receptor activity
B657_RS05735	COG0723	plastoquinol--plastocyanin reductase activity
B657_RS05735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_RS05740	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS05750	COG4903	ComK protein
B657_RS05755	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS05765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_RS05780	COG0398	Pfam SNARE associated Golgi protein
B657_RS05785	COG0681	Belongs to the peptidase S26 family
B657_RS05790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B657_RS05795	COG1846	Transcriptional regulator
B657_RS05800	COG0738	Major facilitator superfamily
B657_RS05805	COG0673	inositol 2-dehydrogenase activity
B657_RS05810	COG0561	phosphatase activity
B657_RS05815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_RS05820	COG1609	Transcriptional regulator
B657_RS05825	COG3180	Ammonia monooxygenase
B657_RS05830	COG2814	Major facilitator Superfamily
B657_RS05830	COG0477	Major facilitator Superfamily
B657_RS05835	COG4533	DNA binding
B657_RS05845	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B657_RS05850	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B657_RS05855	COG1074	ATP-dependent DNA helicase activity
B657_RS05860	COG0420	3'-5' exonuclease activity
B657_RS05865	COG0419	ATPase involved in DNA repair
B657_RS05870	COG1403	HNH endonuclease
B657_RS05915	COG5337	Spore coat protein CotH
B657_RS05920	COG0179	Fumarylacetoacetate (FAA) hydrolase
B657_RS05930	COG1404	Belongs to the peptidase S8 family
B657_RS05940	COG0367	asparagine synthase
B657_RS05945	COG2318	DinB family
B657_RS05950	COG1562	ergosterol biosynthetic process
B657_RS05955	COG0534	Mate efflux family protein
B657_RS05960	COG1917	Cupin 2, conserved barrel domain protein
B657_RS05960	COG2207	Transcriptional regulator
B657_RS05965	COG1609	Transcriptional regulator
B657_RS05970	COG0673	inositol 2-dehydrogenase activity
B657_RS05975	COG2318	DinB family
B657_RS05980	COG1279	arginine transmembrane transporter activity
B657_RS05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_RS05990	COG1357	PFAM Pentapeptide repeats (8 copies)
B657_RS05995	COG2267	carboxylic ester hydrolase activity
B657_RS06000	COG0529	Catalyzes the synthesis of activated sulfate
B657_RS06005	COG2046	Belongs to the sulfate adenylyltransferase family
B657_RS06010	COG0175	sulfate reduction
B657_RS06015	COG2045	Belongs to the ComB family
B657_RS06020	COG1809	phosphosulfolactate synthase activity
B657_RS06025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS06030	COG4948	Mandelate Racemase Muconate Lactonizing
B657_RS06035	COG2814	Major facilitator Superfamily
B657_RS06040	COG0454	-acetyltransferase
B657_RS06045	COG2153	protein acetylation
B657_RS06050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B657_RS06050	COG0646	methionine synthase
B657_RS06055	COG1666	GTP binding
B657_RS06060	COG2996	Protein conserved in bacteria
B657_RS06080	COG1695	Transcriptional regulator
B657_RS06095	COG3227	Zinc metalloprotease (Elastase)
B657_RS06100	COG1307	EDD domain protein, DegV family
B657_RS06105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS06125	COG0561	phosphatase activity
B657_RS06130	COG1073	alpha beta
B657_RS06135	COG2151	metal-sulfur cluster biosynthetic enzyme
B657_RS06145	COG0277	FAD linked oxidase domain protein
B657_RS06150	COG2271	Major facilitator Superfamily
B657_RS06155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B657_RS06160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B657_RS06170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B657_RS06175	COG0505	Belongs to the CarA family
B657_RS06180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B657_RS06185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B657_RS06200	COG2267	carboxylic ester hydrolase activity
B657_RS06210	COG1744	ABC transporter substrate-binding protein PnrA-like
B657_RS06225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_RS06230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B657_RS06235	COG5504	Zn-dependent protease
B657_RS06240	COG0444	Belongs to the ABC transporter superfamily
B657_RS06245	COG4608	Belongs to the ABC transporter superfamily
B657_RS06255	COG0601	transmembrane transport
B657_RS06260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_RS06270	COG0180	Tryptophanyl-tRNA synthetase
B657_RS06275	COG4166	transmembrane transport
B657_RS06280	COG0601	transmembrane transport
B657_RS06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_RS06290	COG0444	Belongs to the ABC transporter superfamily
B657_RS06295	COG4608	Belongs to the ABC transporter superfamily
B657_RS06300	COG2814	Major facilitator Superfamily
B657_RS06305	COG0456	acetyltransferase
B657_RS06310	COG1393	Belongs to the ArsC family
B657_RS06315	COG0861	Integral membrane protein TerC family
B657_RS06320	COG4862	establishment of competence for transformation
B657_RS06325	COG4469	Competence protein
B657_RS06330	COG1164	Oligoendopeptidase f
B657_RS06345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B657_RS06350	COG2346	COG2346, Truncated hemoglobins
B657_RS06355	COG0741	lytic transglycosylase activity
B657_RS06360	COG4116	CYTH
B657_RS06370	COG2357	RelA SpoT domain protein
B657_RS06375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B657_RS06380	COG0564	pseudouridine synthase activity
B657_RS06385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B657_RS06390	COG0475	glutathione-regulated potassium exporter activity
B657_RS06390	COG0569	domain protein
B657_RS06395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B657_RS06400	COG0352	thiamine-phosphate diphosphorylase activity
B657_RS06405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_RS06410	COG2104	thiamine diphosphate biosynthetic process
B657_RS06415	COG2022	thiamine diphosphate biosynthetic process
B657_RS06420	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B657_RS06425	COG0351	phosphomethylpyrimidine kinase
B657_RS06430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B657_RS06490	COG0210	DNA helicase
B657_RS06500	COG2153	protein acetylation
B657_RS06505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B657_RS06510	COG2382	esterase
B657_RS06515	COG0626	cystathionine gamma-synthase activity
B657_RS06520	COG0626	cystathionine gamma-synthase activity
B657_RS06525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS06530	COG5505	Protein of unknown function (DUF819)
B657_RS06565	COG3677	Transposase
B657_RS06580	COG5484	DNA packaging
B657_RS06585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B657_RS06590	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS06600	COG3711	transcriptional antiterminator
B657_RS06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS06605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_RS06605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_RS06610	COG1482	cell wall glycoprotein biosynthetic process
B657_RS06620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS06630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B657_RS06645	COG0109	protoheme IX farnesyltransferase activity
B657_RS06655	COG0726	polysaccharide deacetylase
B657_RS06675	COG5504	Zn-dependent protease
B657_RS06680	COG2205	protein histidine kinase activity
B657_RS06690	COG3383	formate dehydrogenase (NAD+) activity
B657_RS06695	COG2427	Protein of unknown function (DUF1641)
B657_RS06705	COG1051	belongs to the nudix hydrolase family
B657_RS06715	COG2124	cytochrome p450
B657_RS06720	COG1819	glycosyl
B657_RS06730	COG1587	Uroporphyrinogen-III synthase
B657_RS06735	COG0390	transport system, permease component
B657_RS06740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_RS06745	COG0697	spore germination
B657_RS06750	COG4297	protein containing double-stranded beta helix domain
B657_RS06760	COG1252	NADH dehydrogenase
B657_RS06765	COG1904	glucuronate isomerase
B657_RS06770	COG2211	Major facilitator Superfamily
B657_RS06775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B657_RS06780	COG1063	alcohol dehydrogenase
B657_RS06785	COG1312	Catalyzes the dehydration of D-mannonate
B657_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS06795	COG2271	Major facilitator Superfamily
B657_RS06800	COG1609	Transcriptional regulator
B657_RS06805	COG0246	Mannitol dehydrogenase
B657_RS06810	COG2721	sulfolactate sulfo-lyase activity
B657_RS06815	COG0730	response to heat
B657_RS06820	COG2318	DinB family
B657_RS06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B657_RS06830	COG0457	Tetratricopeptide repeat
B657_RS06840	COG2350	Protein conserved in bacteria
B657_RS06845	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_RS06845	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS06845	COG1388	LysM domain
B657_RS06855	COG4195	phage-related replication protein
B657_RS06860	COG3546	catalase activity
B657_RS06865	COG2856	Zn peptidase
B657_RS06870	COG1396	sequence-specific DNA binding
B657_RS06880	COG1522	sequence-specific DNA binding
B657_RS06885	COG1484	DNA-dependent DNA replication
B657_RS06910	COG1595	DNA-templated transcription, initiation
B657_RS06915	COG5484	DNA packaging
B657_RS06915	COG3728	DNA packaging
B657_RS06920	COG1783	phage Terminase large subunit
B657_RS06925	COG5518	Phage portal protein
B657_RS06930	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B657_RS06935	COG4653	Phage capsid family
B657_RS06985	COG3953	SLT domain
B657_RS06985	COG5412	phage tail tape measure protein
B657_RS06990	COG1652	LysM domain
B657_RS06995	COG4193	domain, Protein
B657_RS07005	COG3628	GPW Gp25 family protein
B657_RS07010	COG3299	homolog of phage Mu protein gp47
B657_RS07015	COG3778	Protein conserved in bacteria
B657_RS07055	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_RS07055	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS07070	COG0306	phosphate transporter
B657_RS07075	COG1392	Phosphate transport regulator
B657_RS07080	COG0531	amino acid
B657_RS07085	COG0346	lactoylglutathione lyase activity
B657_RS07090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B657_RS07095	COG0463	Glycosyl transferase, family 2
B657_RS07105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_RS07110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_RS07115	COG2362	D-Aminopeptidase
B657_RS07120	COG0601	transmembrane transport
B657_RS07125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_RS07130	COG0444	Belongs to the ABC transporter superfamily
B657_RS07135	COG4166	transmembrane transport
B657_RS07140	COG1619	proteins homologs of microcin C7 resistance protein MccF
B657_RS07145	COG4948	Mandelate Racemase Muconate Lactonizing
B657_RS07150	COG0791	NLP P60 protein
B657_RS07155	COG4608	Belongs to the ABC transporter superfamily
B657_RS07160	COG2706	6-phosphogluconolactonase activity
B657_RS07165	COG1834	amidinotransferase
B657_RS07170	COG1607	acyl-coa hydrolase
B657_RS07175	COG1017	nitric oxide dioxygenase activity
B657_RS07175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B657_RS07185	COG2323	membrane
B657_RS07190	COG2318	DinB family
B657_RS07195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS07200	COG2076	Multidrug Resistance protein
B657_RS07205	COG2076	Multidrug Resistance protein
B657_RS07210	COG0788	formyltetrahydrofolate deformylase activity
B657_RS07215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B657_RS07220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B657_RS07225	COG1764	response to oxidative stress
B657_RS07230	COG1846	Transcriptional regulator
B657_RS07235	COG1764	response to oxidative stress
B657_RS07245	COG0590	tRNA wobble adenosine to inosine editing
B657_RS07250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_RS07255	COG1404	Belongs to the peptidase S8 family
B657_RS07260	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS07265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B657_RS07270	COG1122	ATPase activity
B657_RS07275	COG4721	ABC-type cobalt transport system, permease component
B657_RS07285	COG0745	RESPONSE REGULATOR receiver
B657_RS07290	COG3850	Histidine kinase
B657_RS07290	COG5002	protein histidine kinase activity
B657_RS07295	COG3212	peptidase
B657_RS07300	COG3212	peptidase
B657_RS07320	COG2239	Acts as a magnesium transporter
B657_RS07325	COG0789	Transcriptional regulator
B657_RS07340	COG1846	Transcriptional regulator
B657_RS07345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_RS07350	COG0726	polysaccharide deacetylase
B657_RS07355	COG1408	metallophosphoesterase
B657_RS07365	COG0463	Glycosyl transferase, family 2
B657_RS07370	COG1793	dna ligase
B657_RS07370	COG3285	dna ligase
B657_RS07375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B657_RS07380	COG3300	MHYT domain
B657_RS07380	COG5001	Diguanylate cyclase
B657_RS07385	COG0586	Pfam SNARE associated Golgi protein
B657_RS07390	COG0861	Integral membrane protein TerC family
B657_RS07395	COG1191	sigma factor activity
B657_RS07415	COG0501	Belongs to the peptidase M48B family
B657_RS07420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B657_RS07435	COG3594	Acyltransferase
B657_RS07440	COG5002	protein histidine kinase activity
B657_RS07445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B657_RS07455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B657_RS07460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B657_RS07465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B657_RS07470	COG0436	Aminotransferase
B657_RS07475	COG1850	ribulose-bisphosphate carboxylase activity
B657_RS07480	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B657_RS07485	COG0235	Class ii aldolase
B657_RS07490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B657_RS07495	COG3339	Conserved Protein
B657_RS07510	COG3852	Histidine kinase
B657_RS07515	COG1846	Transcriptional regulator
B657_RS07520	COG1360	Flagellar Motor Protein
B657_RS07525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B657_RS07530	COG0542	response to heat
B657_RS07535	COG3949	Membrane
B657_RS07540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B657_RS07545	COG0720	synthase
B657_RS07550	COG0602	queuosine metabolic process
B657_RS07555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B657_RS07560	COG1733	regulation of RNA biosynthetic process
B657_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS07570	COG4641	Protein conserved in bacteria
B657_RS07570	COG1388	LysM domain
B657_RS07575	COG1388	LysM domain
B657_RS07580	COG3858	chitin binding
B657_RS07585	COG3858	chitin binding
B657_RS07595	COG4873	Protein conserved in bacteria
B657_RS07610	COG3773	Cell wall hydrolase
B657_RS07615	COG2244	polysaccharide biosynthetic process
B657_RS07620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS07625	COG2217	Heavy metal translocating P-type atpase
B657_RS07635	COG0006	proline dipeptidase activity
B657_RS07645	COG1609	Transcriptional regulator
B657_RS07650	COG3711	transcriptional antiterminator
B657_RS07655	COG2190	(PTS) system
B657_RS07655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS07655	COG1263	PTS System
B657_RS07660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B657_RS07675	COG1533	DNA photolyase activity
B657_RS07680	COG0456	acetyltransferase
B657_RS07685	COG0840	transmembrane signaling receptor activity
B657_RS07690	COG2084	Dehydrogenase
B657_RS07695	COG2340	Cysteine-rich secretory protein family
B657_RS07700	COG0768	penicillin binding
B657_RS07705	COG4191	Histidine kinase
B657_RS07710	COG0436	Aminotransferase
B657_RS07720	COG0835	chemotaxis
B657_RS07720	COG0784	Response regulator, receiver
B657_RS07730	COG2814	Major facilitator Superfamily
B657_RS07735	COG1376	ErfK ybiS ycfS ynhG family protein
B657_RS07740	COG1408	metallophosphoesterase
B657_RS07745	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS07750	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS07755	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS07765	COG2200	EAL domain
B657_RS07775	COG4703	Protein of unknown function (DUF1797)
B657_RS07780	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B657_RS07790	COG0517	IMP dehydrogenase activity
B657_RS07795	COG0583	DNA-binding transcription factor activity
B657_RS07800	COG0716	FMN binding
B657_RS07810	COG0716	FMN binding
B657_RS07815	COG2171	N-acyltransferase activity
B657_RS07820	COG1473	amidohydrolase
B657_RS07830	COG0668	transmembrane transport
B657_RS07835	COG0450	alkyl hydroperoxide reductase
B657_RS07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS07855	COG0746	molybdenum cofactor guanylyltransferase activity
B657_RS07860	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B657_RS07865	COG0303	'Molybdopterin
B657_RS07870	COG1763	Mo-molybdopterin cofactor biosynthetic process
B657_RS07875	COG0314	molybdopterin synthase activity
B657_RS07880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B657_RS07885	COG1132	(ABC) transporter
B657_RS07890	COG1132	(ABC) transporter
B657_RS07900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B657_RS07905	COG1136	(ABC) transporter
B657_RS07910	COG0577	efflux transmembrane transporter activity
B657_RS07915	COG1349	DNA-binding transcription factor activity
B657_RS07920	COG1105	Belongs to the carbohydrate kinase PfkB family
B657_RS07925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS07925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_RS07925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_RS07930	COG0681	Belongs to the peptidase S26 family
B657_RS07940	COG0488	(ABC) transporter
B657_RS07945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B657_RS07950	COG2309	aminopeptidase activity
B657_RS07960	COG1077	Cell shape determining protein MreB Mrl
B657_RS07965	COG2002	toxin-antitoxin pair type II binding
B657_RS07970	COG3852	Histidine kinase
B657_RS07975	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B657_RS07975	COG2105	PFAM AIG2 family protein
B657_RS07980	COG0569	domain protein
B657_RS07985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B657_RS07990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B657_RS07995	COG5503	Protein of unknown function (DUF1447)
B657_RS08000	COG0561	phosphatase activity
B657_RS08005	COG0242	peptide deformylase activity
B657_RS08015	COG0497	DNA recombination
B657_RS08020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_RS08025	COG0022	dehydrogenase e1 component
B657_RS08030	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_RS08035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_RS08040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS08045	COG1982	Orn Lys Arg decarboxylase major
B657_RS08050	COG4476	Belongs to the UPF0223 family
B657_RS08055	COG4493	Belongs to the UPF0637 family
B657_RS08065	COG0483	inositol monophosphate 1-phosphatase activity
B657_RS08075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B657_RS08095	COG1595	DNA-templated transcription, initiation
B657_RS08115	COG1217	gtp-binding protein TYPA
B657_RS08125	COG4896	Protein conserved in bacteria
B657_RS08135	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B657_RS08140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B657_RS08145	COG2066	Belongs to the glutaminase family
B657_RS08150	COG4838	Belongs to the UPF0358 family
B657_RS08155	COG0772	Belongs to the SEDS family
B657_RS08160	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B657_RS08165	COG1612	heme a metabolic process
B657_RS08170	COG0109	protoheme IX farnesyltransferase activity
B657_RS08175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B657_RS08175	COG2010	Cytochrome c
B657_RS08180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B657_RS08185	COG1845	cytochrome c oxidase, subunit III
B657_RS08190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B657_RS08195	COG3336	cytochrome c oxidase
B657_RS08205	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B657_RS08210	COG2340	Cysteine-rich secretory protein family
B657_RS08225	COG3679	Belongs to the UPF0342 family
B657_RS08230	COG4471	UPF0298 protein
B657_RS08235	COG0742	ribosomal rna small subunit methyltransferase
B657_RS08240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B657_RS08245	COG3314	Sporulation integral membrane protein YlbJ
B657_RS08250	COG1752	Esterase of the alpha-beta hydrolase superfamily
B657_RS08255	COG3480	Lon protease (S16) C-terminal proteolytic domain
B657_RS08260	COG1323	Belongs to the UPF0348 family
B657_RS08270	COG1399	metal-binding, possibly nucleic acid-binding protein
B657_RS08285	COG0454	-acetyltransferase
B657_RS08290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B657_RS08295	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B657_RS08300	COG2001	Belongs to the MraZ family
B657_RS08305	COG0275	rRNA processing
B657_RS08310	COG4839	cell division protein FtsL
B657_RS08315	COG0768	penicillin binding
B657_RS08325	COG0768	penicillin binding
B657_RS08335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B657_RS08345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B657_RS08350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B657_RS08355	COG0772	Belongs to the SEDS family
B657_RS08360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_RS08365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B657_RS08370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B657_RS08375	COG3879	Bacterial protein of unknown function (DUF881)
B657_RS08380	COG3879	Bacterial protein of unknown function (DUF881)
B657_RS08385	COG3856	small basic protein
B657_RS08390	COG0849	cell division
B657_RS08395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B657_RS08400	COG1404	Belongs to the peptidase S8 family
B657_RS08400	COG4412	M6 family metalloprotease domain protein
B657_RS08410	COG1191	sigma factor activity
B657_RS08415	COG1191	sigma factor activity
B657_RS08420	COG1119	ATPase activity
B657_RS08425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_RS08430	COG1873	PFAM PRC-barrel domain
B657_RS08435	COG1496	oxidoreductase activity
B657_RS08440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B657_RS08445	COG1799	cell septum assembly
B657_RS08450	COG0762	integral membrane protein
B657_RS08455	COG2302	S4 RNA-binding domain
B657_RS08460	COG3599	regulation of cell shape
B657_RS08465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B657_RS08470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_RS08475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B657_RS08480	COG0564	pseudouridine synthase activity
B657_RS08485	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B657_RS08490	COG2233	PERMEase
B657_RS08495	COG0540	Belongs to the ATCase OTCase family
B657_RS08500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B657_RS08505	COG0505	Belongs to the CarA family
B657_RS08510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B657_RS08515	COG0543	2 iron, 2 sulfur cluster binding
B657_RS08520	COG0167	dihydroorotate dehydrogenase activity
B657_RS08525	COG0284	orotidine-5'-phosphate decarboxylase activity
B657_RS08530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B657_RS08540	COG0175	sulfate reduction
B657_RS08545	COG0306	phosphate transporter
B657_RS08550	COG2046	Belongs to the sulfate adenylyltransferase family
B657_RS08555	COG0529	Catalyzes the synthesis of activated sulfate
B657_RS08560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B657_RS08565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B657_RS08570	COG1648	precorrin-2 dehydrogenase activity
B657_RS08575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B657_RS08580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B657_RS08585	COG1561	YicC-like family, N-terminal region
B657_RS08595	COG0194	GDP metabolic process
B657_RS08600	COG1758	RNA polymerase activity
B657_RS08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B657_RS08610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B657_RS08615	COG0242	peptide deformylase activity
B657_RS08620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B657_RS08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B657_RS08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B657_RS08630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B657_RS08635	COG0631	protein serine/threonine phosphatase activity
B657_RS08640	COG0515	serine threonine protein kinase
B657_RS08640	COG2815	serine threonine protein kinase
B657_RS08645	COG1162	GTPase activity
B657_RS08650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B657_RS08655	COG1564	THIamine pyrophosphokinase
B657_RS08665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B657_RS08670	COG1302	Protein conserved in bacteria
B657_RS08675	COG1461	Dihydroxyacetone kinase
B657_RS08680	COG1760	l-serine dehydratase
B657_RS08685	COG1760	l-serine dehydratase
B657_RS08690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B657_RS08695	COG1349	DNA-binding transcription factor activity
B657_RS08695	COG2050	protein possibly involved in aromatic compounds catabolism
B657_RS08700	COG0416	fatty acid biosynthetic process
B657_RS08705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS08720	COG0571	ribonuclease III activity
B657_RS08725	COG1196	nuclear chromosome segregation
B657_RS08730	COG0552	protein localization to endoplasmic reticulum
B657_RS08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B657_RS08745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B657_RS08750	COG0228	four-way junction DNA binding
B657_RS08755	COG1837	Belongs to the UPF0109 family
B657_RS08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B657_RS08770	COG0336	Belongs to the RNA methyltransferase TrmD family
B657_RS08775	COG0335	large ribosomal subunit rRNA binding
B657_RS08780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B657_RS08785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B657_RS08795	COG2257	FlhB HrpN YscU SpaS Family
B657_RS08800	COG0045	succinate-CoA ligase (ADP-forming) activity
B657_RS08805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B657_RS08810	COG0758	DNA mediated transformation
B657_RS08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B657_RS08820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B657_RS08825	COG4974	Belongs to the 'phage' integrase family
B657_RS08830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B657_RS08835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B657_RS08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B657_RS08845	COG1815	bacterial-type flagellum-dependent cell motility
B657_RS08850	COG1558	bacterial-type flagellum-dependent cell motility
B657_RS08855	COG1677	Flagellar hook-basal body complex protein FliE
B657_RS08860	COG1766	The M ring may be actively involved in energy transduction
B657_RS08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_RS08870	COG1317	bacterial-type flagellum organization
B657_RS08875	COG1157	protein secretion by the type III secretion system
B657_RS08880	COG2882	bacterial-type flagellum organization
B657_RS08885	COG3334	PFAM MgtE intracellular
B657_RS08890	COG3144	bacterial-type flagellum assembly
B657_RS08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B657_RS08900	COG4786	Flagellar basal body rod
B657_RS08905	COG1582	Flagellar protein (FlbD)
B657_RS08910	COG1580	Controls the rotational direction of flagella during chemotaxis
B657_RS08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_RS08920	COG1776	CheC inhibitor of MCP methylation
B657_RS08920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_RS08925	COG2201	protein-glutamate methylesterase activity
B657_RS08930	COG3190	flagellar
B657_RS08935	COG1338	Plays a role in the flagellum-specific transport system
B657_RS08940	COG1987	bacterial-type flagellum assembly
B657_RS08945	COG1684	flagellar biosynthetic protein fliR
B657_RS08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B657_RS08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B657_RS08960	COG1419	protein localization to endoplasmic reticulum
B657_RS08965	COG0455	bacterial-type flagellum organization
B657_RS08970	COG2201	protein-glutamate methylesterase activity
B657_RS08975	COG2198	Histidine kinase
B657_RS08975	COG0643	Histidine kinase
B657_RS08980	COG0835	chemotaxis
B657_RS08985	COG1776	CheC inhibitor of MCP methylation
B657_RS08990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B657_RS08995	COG1191	sigma factor activity
B657_RS09005	COG0052	Belongs to the universal ribosomal protein uS2 family
B657_RS09010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B657_RS09015	COG0528	UMP kinase activity
B657_RS09020	COG0233	cytoplasmic translational termination
B657_RS09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B657_RS09030	COG4589	Belongs to the CDS family
B657_RS09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B657_RS09040	COG0750	zinc metalloprotease
B657_RS09045	COG0442	prolyl-tRNA aminoacylation
B657_RS09050	COG2176	DNA-directed DNA polymerase activity
B657_RS09055	COG0779	Required for maturation of 30S ribosomal subunits
B657_RS09060	COG0195	Participates in both transcription termination and antitermination
B657_RS09065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B657_RS09070	COG1358	cellular component organization or biogenesis
B657_RS09075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B657_RS09080	COG1550	Protein conserved in bacteria
B657_RS09085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B657_RS09090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B657_RS09095	COG0196	riboflavin kinase activity
B657_RS09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B657_RS09105	COG1185	polyribonucleotide nucleotidyltransferase activity
B657_RS09110	COG0726	polysaccharide deacetylase
B657_RS09115	COG0612	Peptidase, M16
B657_RS09120	COG1873	PFAM PRC-barrel domain
B657_RS09130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B657_RS09135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B657_RS09140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B657_RS09145	COG0527	aspartate kinase activity
B657_RS09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B657_RS09155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B657_RS09160	COG0740	serine-type endopeptidase activity
B657_RS09170	COG4980	gas vesicle protein
B657_RS09170	COG1674	ftsk spoiiie
B657_RS09175	COG2188	Transcriptional regulator
B657_RS09180	COG2814	Major facilitator Superfamily
B657_RS09185	COG0612	Peptidase, M16
B657_RS09190	COG0612	Peptidase, M16
B657_RS09195	COG0300	oxidoreductase activity
B657_RS09210	COG1426	Protein conserved in bacteria
B657_RS09215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B657_RS09220	COG1058	Belongs to the CinA family
B657_RS09220	COG1546	Belongs to the CinA family
B657_RS09225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B657_RS09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_RS09235	COG1418	mRNA catabolic process
B657_RS09240	COG1692	metallophosphoesterase
B657_RS09245	COG2359	stage V sporulation protein S
B657_RS09250	COG1063	alcohol dehydrogenase
B657_RS09255	COG0156	8-amino-7-oxononanoate synthase activity
B657_RS09260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B657_RS09265	COG4550	Control of competence regulator ComK, YlbF/YmcA
B657_RS09275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B657_RS09280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B657_RS09300	COG3226	Transcriptional regulator
B657_RS09305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS09315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_RS09320	COG3321	synthase
B657_RS09325	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_RS09325	COG2070	2-Nitropropane dioxygenase
B657_RS09330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_RS09335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B657_RS09340	COG3425	synthase
B657_RS09345	COG1024	Enoyl-CoA hydratase
B657_RS09350	COG1024	Enoyl-CoA hydratase
B657_RS09355	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS09355	COG0300	oxidoreductase activity
B657_RS09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS09355	COG3321	synthase
B657_RS09360	COG0300	oxidoreductase activity
B657_RS09360	COG3321	synthase
B657_RS09360	COG4221	oxidoreductase activity
B657_RS09360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_RS09365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_RS09365	COG3321	synthase
B657_RS09365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS09365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS09375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B657_RS09375	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B657_RS09375	COG3321	synthase
B657_RS09375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_RS09380	COG2124	cytochrome p450
B657_RS09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS09395	COG1404	Belongs to the peptidase S8 family
B657_RS09405	COG4195	phage-related replication protein
B657_RS09410	COG1764	response to oxidative stress
B657_RS09415	COG2076	Multidrug Resistance protein
B657_RS09420	COG2076	Multidrug Resistance protein
B657_RS09435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B657_RS09440	COG1923	regulation of RNA biosynthetic process
B657_RS09455	COG1780	Probably involved in ribonucleotide reductase function
B657_RS09460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_RS09465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_RS09470	COG4112	unkown
B657_RS09475	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS09480	COG0464	growth
B657_RS09490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B657_RS09495	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B657_RS09500	COG0789	Transcriptional regulator
B657_RS09505	COG0174	glutamine synthetase
B657_RS09525	COG4282	regulation of fungal-type cell wall biogenesis
B657_RS09535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS09560	COG0135	phosphoribosylanthranilate isomerase activity
B657_RS09565	COG2211	Major facilitator Superfamily
B657_RS09570	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_RS09575	COG1940	carbohydrate kinase activity
B657_RS09580	COG2115	Belongs to the xylose isomerase family
B657_RS09585	COG1070	Carbohydrate kinase
B657_RS09590	COG1525	nuclease
B657_RS09595	COG2814	Major facilitator Superfamily
B657_RS09600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B657_RS09610	COG0756	dUTP diphosphatase activity
B657_RS09620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B657_RS09645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_RS09660	COG3832	glyoxalase III activity
B657_RS09675	COG0697	spore germination
B657_RS09680	COG0531	amino acid
B657_RS09710	COG4195	phage-related replication protein
B657_RS09720	COG0346	lactoylglutathione lyase activity
B657_RS09730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B657_RS09735	COG1388	LysM domain
B657_RS09740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_RS09745	COG4224	UPF0291 protein
B657_RS09750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B657_RS09760	COG3763	UPF0154 protein
B657_RS09770	COG0785	Cytochrome C biogenesis protein
B657_RS09775	COG2201	protein-glutamate methylesterase activity
B657_RS09780	COG4846	Membrane protein involved in cytochrome C biogenesis
B657_RS09790	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_RS09805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B657_RS09810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS09830	COG0824	Thioesterase
B657_RS09840	COG4841	protein insertion into membrane
B657_RS09845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B657_RS09850	COG1832	CoA-binding protein
B657_RS09855	COG0187	DNA topoisomerase II activity
B657_RS09860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B657_RS09875	COG1115	amino acid carrier protein
B657_RS09880	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B657_RS09890	COG5520	Belongs to the glycosyl hydrolase 30 family
B657_RS09895	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_RS09900	COG2246	polysaccharide biosynthetic process
B657_RS09905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_RS09910	COG0586	Pfam SNARE associated Golgi protein
B657_RS09915	COG2404	hydrolase activity, acting on ester bonds
B657_RS09920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B657_RS09925	COG1024	Enoyl-CoA hydratase
B657_RS09930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B657_RS09935	COG0511	ligase activity, forming carbon-carbon bonds
B657_RS09940	COG0439	Biotin carboxylase
B657_RS09945	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS09950	COG1960	acyl-CoA dehydrogenase activity
B657_RS09965	COG1649	PFAM Uncharacterised BCR, COG1649
B657_RS09975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS09975	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B657_RS09980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS09985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS09990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS10000	COG2027	D-alanyl-D-alanine carboxypeptidase
B657_RS10005	COG2017	converts alpha-aldose to the beta-anomer
B657_RS10010	COG0534	Mate efflux family protein
B657_RS10025	COG0582	viral genome integration into host DNA
B657_RS10030	COG0166	Belongs to the GPI family
B657_RS10035	COG0405	Gamma-glutamyltransferase
B657_RS10040	COG0583	DNA-binding transcription factor activity
B657_RS10050	COG0493	'glutamate synthase
B657_RS10055	COG0070	glutamate synthase
B657_RS10055	COG0067	glutamate synthase
B657_RS10055	COG0069	glutamate synthase activity
B657_RS10060	COG0583	DNA-binding transcription factor activity
B657_RS10065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B657_RS10070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_RS10080	COG0300	oxidoreductase activity
B657_RS10085	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B657_RS10095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS10100	COG2814	Major facilitator Superfamily
B657_RS10105	COG1070	Carbohydrate kinase
B657_RS10110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B657_RS10115	COG0243	molybdopterin cofactor binding
B657_RS10140	COG5278	phosphoserine phosphatase activity
B657_RS10140	COG0840	transmembrane signaling receptor activity
B657_RS10145	COG2368	4-hydroxyphenylacetate
B657_RS10150	COG4305	rare lipoprotein A
B657_RS10155	COG3619	membrane
B657_RS10160	COG3866	Pectate lyase
B657_RS10165	COG2135	peptidase activity
B657_RS10175	COG2140	Oxalate decarboxylase
B657_RS10185	COG0456	acetyltransferase
B657_RS10200	COG2720	vancomycin resistance protein
B657_RS10210	COG3655	Transcriptional regulator
B657_RS10215	COG3739	integral membrane protein
B657_RS10220	COG0583	DNA-binding transcription factor activity
B657_RS10225	COG0697	spore germination
B657_RS10235	COG0693	protein deglycase activity
B657_RS10240	COG2367	Beta-lactamase
B657_RS10260	COG3848	Pyruvate phosphate dikinase
B657_RS10260	COG0574	Belongs to the PEP-utilizing enzyme family
B657_RS10265	COG0726	polysaccharide deacetylase
B657_RS10270	COG2314	TM2 domain
B657_RS10275	COG1396	sequence-specific DNA binding
B657_RS10290	COG2135	peptidase activity
B657_RS10295	COG1793	dna ligase
B657_RS10325	COG0457	Tetratricopeptide repeat
B657_RS10335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_RS10340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_RS10355	COG5290	Psort location Cytoplasmic, score
B657_RS10375	COG5444	nuclease activity
B657_RS10380	COG4282	regulation of fungal-type cell wall biogenesis
B657_RS10385	COG1231	oxidoreductase activity
B657_RS10390	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_RS10395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_RS10400	COG2207	Transcriptional regulator
B657_RS10400	COG0662	Cupin 2, conserved barrel domain protein
B657_RS10405	COG0456	acetyltransferase
B657_RS10410	COG1309	transcriptional regulator
B657_RS10415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS10420	COG3708	Transcriptional regulator
B657_RS10425	COG2378	regulation of single-species biofilm formation
B657_RS10435	COG0640	Transcriptional regulator
B657_RS10440	COG0741	lytic transglycosylase activity
B657_RS10445	COG2322	membrane
B657_RS10460	COG1619	proteins homologs of microcin C7 resistance protein MccF
B657_RS10465	COG3239	Fatty acid desaturase
B657_RS10470	COG4585	Histidine kinase
B657_RS10475	COG2197	response regulator
B657_RS10480	COG1388	LysM domain
B657_RS10480	COG3584	3D domain protein
B657_RS10485	COG0514	ATP-dependent DNA helicase (RecQ)
B657_RS10495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B657_RS10500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_RS10515	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS10545	COG1657	PFAM Prenyltransferase squalene oxidase
B657_RS10550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B657_RS10555	COG0733	neurotransmitter:sodium symporter activity
B657_RS10560	COG0385	Bile acid
B657_RS10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_RS10570	COG0567	Dehydrogenase, E1 component
B657_RS10575	COG4548	von Willebrand factor, type A
B657_RS10580	COG0714	Associated with various cellular activities
B657_RS10585	COG2032	superoxide dismutase activity
B657_RS10590	COG0791	NLP P60 protein
B657_RS10590	COG1388	LysM domain
B657_RS10595	COG1819	glycosyl
B657_RS10600	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B657_RS10605	COG0534	Mate efflux family protein
B657_RS10610	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_RS10620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_RS10630	COG2962	Rard protein
B657_RS10645	COG2610	gluconate transmembrane transporter activity
B657_RS10650	COG1942	4-Oxalocrotonate Tautomerase
B657_RS10655	COG1733	regulation of RNA biosynthetic process
B657_RS10660	COG0778	Nitroreductase
B657_RS10665	COG0400	carboxylic ester hydrolase activity
B657_RS10670	COG0346	lactoylglutathione lyase activity
B657_RS10680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_RS10685	COG0793	Belongs to the peptidase S41A family
B657_RS10685	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS10690	COG2226	methyltransferase
B657_RS10700	COG1876	peptidase activity
B657_RS10705	COG0813	purine-nucleoside phosphorylase activity
B657_RS10720	COG0671	phosphoesterase, PA-phosphatase related
B657_RS10745	COG4479	Belongs to the UPF0346 family
B657_RS10755	COG1509	lysine 2,3-aminomutase activity
B657_RS10760	COG0456	acetyltransferase
B657_RS10765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_RS10770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B657_RS10775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B657_RS10780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_RS10795	COG0456	acetyltransferase
B657_RS10800	COG0463	Glycosyl transferase, family 2
B657_RS10815	COG4641	Protein conserved in bacteria
B657_RS10820	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B657_RS10825	COG1086	Polysaccharide biosynthesis protein
B657_RS10835	COG3331	DNA recombination
B657_RS10885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_RS10920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B657_RS10925	COG0756	dUTP diphosphatase activity
B657_RS10930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS10945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_RS10960	COG1372	Participates in initiation and elongation during chromosome replication
B657_RS10960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_RS10965	COG1780	Probably involved in ribonucleotide reductase function
B657_RS11055	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_RS11065	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B657_RS11070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B657_RS11095	COG3584	3D domain protein
B657_RS11100	COG0587	DNA-directed DNA polymerase activity
B657_RS11105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B657_RS11110	COG0358	DNA primase activity
B657_RS11115	COG0305	Participates in initiation and elongation during chromosome replication
B657_RS11125	COG2887	Belongs to the helicase family. UvrD subfamily
B657_RS11155	COG3420	alginic acid biosynthetic process
B657_RS11155	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_RS11160	COG4195	phage-related replication protein
B657_RS11175	COG2135	peptidase activity
B657_RS11180	COG1793	dna ligase
B657_RS11235	COG4474	Belongs to the UPF0398 family
B657_RS11245	COG1388	LysM domain
B657_RS11265	COG3646	Phage regulatory protein
B657_RS11265	COG3645	SOS response
B657_RS11320	COG3655	Transcriptional regulator
B657_RS11335	COG0582	viral genome integration into host DNA
B657_RS11410	COG3655	Transcriptional regulator
B657_RS11445	COG1395	domain, Protein
B657_RS11460	COG0776	regulation of translation
B657_RS11490	COG4373	Mu-like prophage FluMu protein gp28
B657_RS11590	COG0582	viral genome integration into host DNA
B657_RS11620	COG1196	nuclear chromosome segregation
B657_RS11620	COG0741	lytic transglycosylase activity
B657_RS11620	COG0739	heme binding
B657_RS11630	COG2433	Pfam Transposase IS66
B657_RS11640	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_RS11640	COG4632	Exopolysaccharide biosynthesis protein
B657_RS11655	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_RS11670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B657_RS11675	COG0463	Glycosyl transferase, family 2
B657_RS11680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS11685	COG2274	protein secretion by the type I secretion system
B657_RS11685	COG3271	cysteine-type peptidase activity
B657_RS11700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_RS11730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_RS11745	COG5444	nuclease activity
B657_RS11750	COG4282	regulation of fungal-type cell wall biogenesis
B657_RS11760	COG1525	nuclease
B657_RS11770	COG2746	aminoglycoside 3-N-acetyltransferase activity
B657_RS11795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_RS11800	COG1086	Polysaccharide biosynthesis protein
B657_RS11805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B657_RS11810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B657_RS11815	COG1846	Transcriptional regulator
B657_RS11820	COG0534	Mate efflux family protein
B657_RS11830	COG4698	Protein conserved in bacteria
B657_RS11835	COG2755	lipolytic protein G-D-S-L family
B657_RS11840	COG1999	signal sequence binding
B657_RS11855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B657_RS11860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B657_RS11865	COG1272	protein, Hemolysin III
B657_RS11870	COG0204	Acyl-transferase
B657_RS11875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_RS11880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B657_RS11885	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B657_RS11895	COG2521	methyltransferase
B657_RS11895	COG2136	Putative SAM-dependent methyltransferase
B657_RS11905	COG0129	dihydroxy-acid dehydratase activity
B657_RS11910	COG1413	lyase activity
B657_RS11915	COG1418	mRNA catabolic process
B657_RS11920	COG0386	Belongs to the glutathione peroxidase family
B657_RS11925	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B657_RS11930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_RS11935	COG1278	Cold shock
B657_RS11955	COG0328	RNA-DNA hybrid ribonuclease activity
B657_RS11960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B657_RS11965	COG0328	RNA-DNA hybrid ribonuclease activity
B657_RS11975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_RS11995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B657_RS12000	COG1755	Isoprenylcysteine carboxyl methyltransferase
B657_RS12005	COG3424	synthase
B657_RS12010	COG2233	PERMEase
B657_RS12015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_RS12020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B657_RS12030	COG0800	Aldolase
B657_RS12035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_RS12040	COG1609	Transcriptional regulator
B657_RS12045	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B657_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS12055	COG1199	ATP-dependent helicase activity
B657_RS12065	COG0116	Belongs to the methyltransferase superfamily
B657_RS12075	COG4474	Belongs to the UPF0398 family
B657_RS12085	COG3359	exonuclease
B657_RS12090	COG1111	helicase
B657_RS12090	COG1205	dead DEAH box helicase
B657_RS12095	COG2190	(PTS) system
B657_RS12100	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_RS12135	COG3331	DNA recombination
B657_RS12140	COG4499	WXG100 protein secretion system (Wss), protein YukC
B657_RS12140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_RS12150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B657_RS12155	COG3935	DnaD domain protein
B657_RS12160	COG0017	Asparaginyl-tRNA synthetase
B657_RS12165	COG0436	Aminotransferase
B657_RS12170	COG5353	protein conserved in bacteria
B657_RS12180	COG1199	ATP-dependent helicase activity
B657_RS12180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B657_RS12185	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B657_RS12190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B657_RS12195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B657_RS12205	COG0617	tRNA 3'-terminal CCA addition
B657_RS12210	COG0438	transferase activity, transferring glycosyl groups
B657_RS12215	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_RS12220	COG1803	Methylglyoxal synthase
B657_RS12225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B657_RS12230	COG1694	Mazg nucleotide pyrophosphohydrolase
B657_RS12235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS12245	COG4347	Protein of unknown function (DUF1405)
B657_RS12250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B657_RS12250	COG2010	Cytochrome c
B657_RS12255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B657_RS12260	COG0723	plastoquinol--plastocyanin reductase activity
B657_RS12270	COG5582	Belongs to the UPF0302 family
B657_RS12275	COG0457	Tetratricopeptide repeat
B657_RS12280	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B657_RS12285	COG0287	Prephenate dehydrogenase
B657_RS12290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B657_RS12295	COG0159	tryptophan synthase activity
B657_RS12300	COG0133	tryptophan synthase activity
B657_RS12305	COG0135	phosphoribosylanthranilate isomerase activity
B657_RS12315	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B657_RS12320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B657_RS12325	COG4401	Chorismate mutase type I
B657_RS12330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B657_RS12335	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B657_RS12340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B657_RS12350	COG0105	UTP biosynthetic process
B657_RS12355	COG0142	geranyltranstransferase activity
B657_RS12360	COG2226	methyltransferase
B657_RS12365	COG0142	geranyltranstransferase activity
B657_RS12375	COG0302	gtp cyclohydrolase
B657_RS12380	COG0776	regulation of translation
B657_RS12385	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B657_RS12400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B657_RS12405	COG1160	GTP binding
B657_RS12430	COG1304	FMN binding
B657_RS12435	COG0539	negative regulation of cytoplasmic translation
B657_RS12440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B657_RS12450	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B657_RS12455	COG2959	enzyme of heme biosynthesis
B657_RS12460	COG3773	Cell wall hydrolase
B657_RS12460	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS12465	COG2339	peptidase activity
B657_RS12470	COG0492	ferredoxin-NADP+ reductase activity
B657_RS12475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_RS12480	COG4862	establishment of competence for transformation
B657_RS12485	COG1408	metallophosphoesterase
B657_RS12495	COG1388	LysM domain
B657_RS12500	COG1266	CAAX protease self-immunity
B657_RS12505	COG0514	ATP-dependent DNA helicase (RecQ)
B657_RS12510	COG4955	Helix-turn-helix domain
B657_RS12515	COG1141	Ferredoxin
B657_RS12520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B657_RS12530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B657_RS12535	COG0710	3-dehydroquinate dehydratase activity
B657_RS12545	COG1595	DNA-templated transcription, initiation
B657_RS12550	COG5002	protein histidine kinase activity
B657_RS12555	COG0745	RESPONSE REGULATOR receiver
B657_RS12560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B657_RS12565	COG1333	cytochrome c biogenesis protein
B657_RS12570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS12575	COG1187	pseudouridine synthase activity
B657_RS12580	COG0700	Nucleoside recognition
B657_RS12585	COG2715	membrane protein required for spore maturation
B657_RS12590	COG1686	Belongs to the peptidase S11 family
B657_RS12600	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B657_RS12605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B657_RS12610	COG1547	Domain of unknown function (DUF309)
B657_RS12615	COG0456	acetyltransferase
B657_RS12620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B657_RS12625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B657_RS12625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B657_RS12630	COG0307	riboflavin synthase, alpha
B657_RS12635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B657_RS12635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B657_RS12645	COG0681	Belongs to the peptidase S26 family
B657_RS12650	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B657_RS12675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B657_RS12680	COG4086	secreted protein
B657_RS12685	COG0019	diaminopimelate decarboxylase activity
B657_RS12690	COG0697	spore germination
B657_RS12705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_RS12725	COG1191	sigma factor activity
B657_RS12730	COG2172	sigma factor antagonist activity
B657_RS12735	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS12740	COG1686	Belongs to the peptidase S11 family
B657_RS12745	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B657_RS12750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B657_RS12755	COG4974	Belongs to the 'phage' integrase family
B657_RS12765	COG0735	belongs to the Fur family
B657_RS12770	COG1300	Membrane
B657_RS12780	COG0281	malic enzyme
B657_RS12785	COG1757	Na H antiporter
B657_RS12790	COG1027	Aspartate ammonia-lyase
B657_RS12795	COG0252	asparaginase activity
B657_RS12800	COG1396	sequence-specific DNA binding
B657_RS12805	COG1379	DNA repair
B657_RS12810	COG0494	nUDIX hydrolase
B657_RS12820	COG0667	Aldo Keto reductase
B657_RS12830	COG1073	alpha beta
B657_RS12840	COG4918	Iron-sulphur cluster biosynthesis
B657_RS12845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B657_RS12845	COG0456	acetyltransferase
B657_RS12850	COG2329	Antibiotic biosynthesis monooxygenase
B657_RS12855	COG0456	acetyltransferase
B657_RS12865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_RS12875	COG2211	Major facilitator Superfamily
B657_RS12885	COG0346	lactoylglutathione lyase activity
B657_RS12890	COG1072	(Pantothenic acid kinase))
B657_RS12895	COG3048	D-serine ammonia-lyase activity
B657_RS12900	COG0300	oxidoreductase activity
B657_RS12905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS12910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_RS12915	COG4187	Peptidase family M20/M25/M40
B657_RS12920	COG1902	pentaerythritol trinitrate reductase activity
B657_RS12925	COG0596	Alpha beta hydrolase
B657_RS12930	COG1234	tRNA 3'-trailer cleavage
B657_RS12935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B657_RS12940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B657_RS12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_RS12955	COG0706	membrane insertase activity
B657_RS12960	COG3361	conserved protein (COG2071)
B657_RS12965	COG2195	Cleaves the N-terminal amino acid of tripeptides
B657_RS12970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B657_RS12975	COG0346	lactoylglutathione lyase activity
B657_RS12985	COG1376	ErfK ybiS ycfS ynhG family protein
B657_RS12990	COG4129	membrane
B657_RS12995	COG1126	abc transporter atp-binding protein
B657_RS13000	COG0765	amino acid transport
B657_RS13005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS13015	COG1597	lipid kinase activity
B657_RS13020	COG2814	Major facilitator Superfamily
B657_RS13025	COG4978	Transcriptional regulator
B657_RS13025	COG0789	Transcriptional regulator
B657_RS13030	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_RS13035	COG0022	dehydrogenase e1 component
B657_RS13040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_RS13045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_RS13050	COG3426	butyrate kinase activity
B657_RS13055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_RS13060	COG0280	phosphate acetyltransferase
B657_RS13065	COG3290	protein histidine kinase activity
B657_RS13065	COG3829	transcription factor binding
B657_RS13075	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B657_RS13080	COG2079	MmgE PrpD family protein
B657_RS13085	COG0372	Belongs to the citrate synthase family
B657_RS13090	COG1960	acyl-CoA dehydrogenase activity
B657_RS13095	COG1250	3-hydroxyacyl-CoA dehydrogenase
B657_RS13100	COG0183	Belongs to the thiolase family
B657_RS13105	COG0584	glycerophosphoryl diester phosphodiesterase
B657_RS13110	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS13125	COG1902	pentaerythritol trinitrate reductase activity
B657_RS13135	COG0745	RESPONSE REGULATOR receiver
B657_RS13145	COG0750	zinc metalloprotease
B657_RS13150	COG0497	DNA recombination
B657_RS13155	COG1438	arginine binding
B657_RS13160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B657_RS13165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B657_RS13170	COG0142	geranyltranstransferase activity
B657_RS13175	COG1722	exodeoxyribonuclease VII activity
B657_RS13180	COG1570	exodeoxyribonuclease VII activity
B657_RS13185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B657_RS13190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B657_RS13195	COG1302	Protein conserved in bacteria
B657_RS13200	COG0439	Biotin carboxylase
B657_RS13205	COG0511	ligase activity, forming carbon-carbon bonds
B657_RS13245	COG3854	ATPases associated with a variety of cellular activities
B657_RS13255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B657_RS13260	COG0006	proline dipeptidase activity
B657_RS13265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B657_RS13275	COG3872	metal-dependent enzyme
B657_RS13285	COG1752	Esterase of the alpha-beta hydrolase superfamily
B657_RS13290	COG1321	iron dependent repressor
B657_RS13295	COG0095	Lipoate-protein ligase
B657_RS13300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_RS13305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B657_RS13310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B657_RS13315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B657_RS13320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B657_RS13335	COG1396	sequence-specific DNA binding
B657_RS13345	COG0681	Belongs to the peptidase S26 family
B657_RS13370	COG4940	Competence protein ComGF
B657_RS13380	COG4970	Tfp pilus assembly protein FimT
B657_RS13385	COG4537	Required for transformation and DNA binding
B657_RS13390	COG1459	type II secretion system
B657_RS13395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B657_RS13405	COG0598	Magnesium transport protein CorA
B657_RS13410	COG1253	flavin adenine dinucleotide binding
B657_RS13415	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS13425	COG1393	Belongs to the ArsC family
B657_RS13435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS13445	COG0011	TIGRFAM Protein of
B657_RS13455	COG2866	Carboxypeptidase
B657_RS13460	COG1368	sulfuric ester hydrolase activity
B657_RS13465	COG1940	carbohydrate kinase activity
B657_RS13470	COG4483	Protein conserved in bacteria
B657_RS13475	COG0705	Rhomboid family
B657_RS13475	COG0457	Tetratricopeptide repeat
B657_RS13485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B657_RS13495	COG0438	transferase activity, transferring glycosyl groups
B657_RS13510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B657_RS13515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_RS13520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_RS13525	COG0581	inorganic phosphate transmembrane transporter activity
B657_RS13530	COG0573	inorganic phosphate transmembrane transporter activity
B657_RS13535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B657_RS13540	COG0768	penicillin binding
B657_RS13545	COG0477	Major facilitator Superfamily
B657_RS13550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B657_RS13555	COG2839	Protein conserved in bacteria
B657_RS13560	COG5521	maltodextrose utilization protein MalA
B657_RS13570	COG1388	LysM domain
B657_RS13575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B657_RS13580	COG4709	membrane
B657_RS13585	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B657_RS13590	COG0735	belongs to the Fur family
B657_RS13595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS13605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B657_RS13610	COG0513	Belongs to the DEAD box helicase family
B657_RS13620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B657_RS13625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B657_RS13630	COG2384	SAM-dependent methyltransferase
B657_RS13635	COG2010	Cytochrome c
B657_RS13640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B657_RS13645	COG0358	DNA primase activity
B657_RS13650	COG1671	Belongs to the UPF0178 family
B657_RS13655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B657_RS13660	COG0517	IMP dehydrogenase activity
B657_RS13665	COG0751	glycine-tRNA ligase activity
B657_RS13670	COG0752	glycyl-tRNA synthetase alpha subunit
B657_RS13675	COG1381	Involved in DNA repair and RecF pathway recombination
B657_RS13685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B657_RS13690	COG0295	cytidine deaminase activity
B657_RS13695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B657_RS13700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B657_RS13705	COG1480	7TM receptor with intracellular HD hydrolase
B657_RS13715	COG1702	phosphate starvation-inducible protein PhoH
B657_RS13720	COG0561	phosphatase activity
B657_RS13735	COG4864	UPF0365 protein
B657_RS13740	COG1030	water channel activity
B657_RS13745	COG1610	YqeY-like protein
B657_RS13755	COG1283	sodium-dependent phosphate transmembrane transporter activity
B657_RS13760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B657_RS13765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B657_RS13770	COG2264	protein methyltransferase activity
B657_RS13775	COG0484	heat shock protein binding
B657_RS13780	COG0443	Heat shock 70 kDa protein
B657_RS13785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B657_RS13790	COG1420	regulation of RNA biosynthetic process
B657_RS13795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B657_RS13800	COG0481	GTPase activity
B657_RS13810	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS13815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B657_RS13820	COG0268	Binds directly to 16S ribosomal RNA
B657_RS13825	COG1466	dna polymerase III delta subunit
B657_RS13835	COG2333	competence protein COMEC
B657_RS13835	COG0658	competence protein
B657_RS13840	COG2131	deaminase
B657_RS13845	COG1596	polysaccharide export
B657_RS13845	COG1555	photosystem II stabilization
B657_RS13850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_RS13855	COG2226	methyltransferase
B657_RS13860	COG0799	negative regulation of ribosome biogenesis
B657_RS13865	COG1713	HD superfamily hydrolase involved in NAD metabolism
B657_RS13870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B657_RS13875	COG1534	Rna-binding protein
B657_RS13880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B657_RS13885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B657_RS13890	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B657_RS13905	COG2755	lipolytic protein G-D-S-L family
B657_RS13910	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS13910	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_RS13915	COG0398	Pfam SNARE associated Golgi protein
B657_RS13920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B657_RS13930	COG3209	COG3209 Rhs family protein
B657_RS13945	COG3223	Belongs to the PsiE family
B657_RS13950	COG5002	protein histidine kinase activity
B657_RS13950	COG0642	Histidine kinase
B657_RS13955	COG0745	RESPONSE REGULATOR receiver
B657_RS13960	COG2311	Membrane
B657_RS13970	COG0454	-acetyltransferase
B657_RS13975	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_RS13985	COG0730	response to heat
B657_RS13990	COG0425	Belongs to the sulfur carrier protein TusA family
B657_RS13995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS13995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_RS14005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_RS14005	COG0425	Belongs to the sulfur carrier protein TusA family
B657_RS14010	COG2210	Belongs to the sulfur carrier protein TusA family
B657_RS14015	COG1937	Protein conserved in bacteria
B657_RS14020	COG0662	Cupin 2, conserved barrel domain protein
B657_RS14035	COG0789	Transcriptional regulator
B657_RS14035	COG4978	Transcriptional regulator
B657_RS14040	COG2814	Major facilitator Superfamily
B657_RS14045	COG0456	acetyltransferase
B657_RS14050	COG1253	flavin adenine dinucleotide binding
B657_RS14060	COG0697	spore germination
B657_RS14065	COG0583	DNA-binding transcription factor activity
B657_RS14070	COG2072	flavoprotein involved in K transport
B657_RS14075	COG1230	cation diffusion facilitator family transporter
B657_RS14080	COG1942	4-Oxalocrotonate Tautomerase
B657_RS14085	COG0583	DNA-binding transcription factor activity
B657_RS14095	COG1114	Component of the transport system for branched-chain amino acids
B657_RS14100	COG1687	branched-chain amino acid
B657_RS14105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B657_RS14110	COG1522	sequence-specific DNA binding
B657_RS14115	COG2732	(Barnase) inhibitor
B657_RS14120	COG2124	cytochrome p450
B657_RS14130	COG1335	isochorismatase
B657_RS14140	COG2318	DinB family
B657_RS14150	COG2070	2-Nitropropane dioxygenase
B657_RS14155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B657_RS14170	COG3443	Belongs to the bacterial solute-binding protein 9 family
B657_RS14175	COG1595	DNA-templated transcription, initiation
B657_RS14180	COG0667	Aldo Keto reductase
B657_RS14185	COG2851	Citrate transporter
B657_RS14190	COG0583	DNA-binding transcription factor activity
B657_RS14195	COG2828	Protein conserved in bacteria
B657_RS14200	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS14205	COG5566	PFAM Mor transcription activator
B657_RS14210	COG0596	Alpha beta hydrolase
B657_RS14215	COG4991	sh3 domain protein
B657_RS14220	COG4991	sh3 domain protein
B657_RS14225	COG0346	lactoylglutathione lyase activity
B657_RS14235	COG5577	PFAM Coat F domain
B657_RS14240	COG1063	alcohol dehydrogenase
B657_RS14250	COG5577	PFAM Coat F domain
B657_RS14255	COG0789	Transcriptional regulator
B657_RS14265	COG1064	alcohol dehydrogenase
B657_RS14270	COG0693	protein deglycase activity
B657_RS14275	COG1621	beta-fructofuranosidase activity
B657_RS14280	COG3716	PTS system mannose fructose sorbose family IID component
B657_RS14285	COG3715	PTS system
B657_RS14290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS14295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS14300	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B657_RS14300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B657_RS14305	COG1113	amino acid transport
B657_RS14310	COG1280	lysine exporter protein (LysE YggA)
B657_RS14315	COG1378	Sugar-specific transcriptional regulator TrmB
B657_RS14320	COG1595	DNA-templated transcription, initiation
B657_RS14330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B657_RS14330	COG2755	lipolytic protein G-D-S-L family
B657_RS14340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_RS14340	COG2124	cytochrome p450
B657_RS14345	COG1309	transcriptional regulator
B657_RS14350	COG2226	methyltransferase
B657_RS14360	COG2116	formate transmembrane transporter activity
B657_RS14365	COG5609	conserved protein (DUF2294)
B657_RS14370	COG3383	formate dehydrogenase (NAD+) activity
B657_RS14375	COG2427	Protein of unknown function (DUF1641)
B657_RS14385	COG0626	cystathionine gamma-synthase activity
B657_RS14390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_RS14395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B657_RS14400	COG2226	methyltransferase
B657_RS14415	COG0768	penicillin binding
B657_RS14420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B657_RS14425	COG0572	uridine kinase
B657_RS14430	COG0826	peptidase U32
B657_RS14435	COG0826	peptidase U32
B657_RS14440	COG4122	O-methyltransferase activity
B657_RS14445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B657_RS14450	COG3906	Belongs to the UPF0473 family
B657_RS14455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B657_RS14460	COG4472	Bacterial protein of unknown function (DUF965)
B657_RS14465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B657_RS14470	COG0628	permease
B657_RS14475	COG1126	abc transporter atp-binding protein
B657_RS14480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS14485	COG0765	amino acid transport
B657_RS14490	COG0765	amino acid transport
B657_RS14505	COG3881	PFAM PRC-barrel domain
B657_RS14510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B657_RS14515	COG0457	Tetratricopeptide repeat
B657_RS14520	COG0482	sulfurtransferase activity
B657_RS14525	COG1104	cysteine desulfurase activity
B657_RS14530	COG1959	2 iron, 2 sulfur cluster binding
B657_RS14535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B657_RS14540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B657_RS14550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B657_RS14555	COG0124	histidyl-tRNA synthetase
B657_RS14565	COG4991	sh3 domain protein
B657_RS14565	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS14565	COG3103	Sh3 type 3 domain protein
B657_RS14570	COG1490	D-aminoacyl-tRNA deacylase activity
B657_RS14575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B657_RS14580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_RS14585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B657_RS14585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B657_RS14590	COG5416	Lipopolysaccharide assembly protein A domain
B657_RS14595	COG0490	domain, Protein
B657_RS14600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B657_RS14600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B657_RS14610	COG2244	polysaccharide biosynthetic process
B657_RS14615	COG2323	membrane
B657_RS14625	COG1862	Preprotein translocase
B657_RS14630	COG0343	queuine tRNA-ribosyltransferase activity
B657_RS14635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B657_RS14645	COG2255	four-way junction helicase activity
B657_RS14650	COG0632	four-way junction helicase activity
B657_RS14660	COG2814	Major facilitator Superfamily
B657_RS14665	COG0673	inositol 2-dehydrogenase activity
B657_RS14670	COG2112	serine threonine protein kinase
B657_RS14690	COG1115	amino acid carrier protein
B657_RS14695	COG0217	transcriptional regulatory protein
B657_RS14705	COG1388	LysM domain
B657_RS14710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B657_RS14715	COG0157	Belongs to the NadC ModD family
B657_RS14720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B657_RS14725	COG1104	cysteine desulfurase activity
B657_RS14730	COG1827	regulation of RNA biosynthetic process
B657_RS14735	COG0077	Prephenate dehydratase
B657_RS14740	COG4492	Belongs to the UPF0735 family
B657_RS14745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B657_RS14750	COG3290	protein histidine kinase activity
B657_RS14760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B657_RS14765	COG2868	ribosomal protein
B657_RS14770	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B657_RS14775	COG1994	Peptidase M50
B657_RS14780	COG0739	heme binding
B657_RS14785	COG2894	cell division
B657_RS14790	COG0850	regulation of cytokinetic process
B657_RS14795	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B657_RS14805	COG1077	Cell shape determining protein MreB Mrl
B657_RS14810	COG2003	Belongs to the UPF0758 family
B657_RS14815	COG0424	maF-like protein
B657_RS14825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B657_RS14830	COG0285	dihydrofolate synthase activity
B657_RS14835	COG0525	valine-tRNA ligase activity
B657_RS14845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_RS14850	COG1388	LysM domain
B657_RS14855	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B657_RS14860	COG0113	porphobilinogen synthase activity
B657_RS14865	COG1587	Uroporphyrinogen-III synthase
B657_RS14870	COG0181	hydroxymethylbilane synthase activity
B657_RS14875	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B657_RS14880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B657_RS14890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B657_RS14895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B657_RS14900	COG1067	ATP-dependent peptidase activity
B657_RS14900	COG0470	DNA polymerase III
B657_RS14905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B657_RS14910	COG0544	peptidyl-prolyl cis-trans isomerase activity
B657_RS14915	COG0457	Tetratricopeptide repeat
B657_RS14915	COG1477	protein flavinylation
B657_RS14920	COG0066	3-isopropylmalate dehydratase activity
B657_RS14925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B657_RS14930	COG0473	3-isopropylmalate dehydrogenase activity
B657_RS14935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B657_RS14940	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B657_RS14945	COG0440	acetolactate synthase activity
B657_RS14950	COG0028	Belongs to the TPP enzyme family
B657_RS14960	COG0454	-acetyltransferase
B657_RS14970	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B657_RS14980	COG0622	Phosphoesterase
B657_RS14985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B657_RS14990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B657_RS14995	COG5401	PFAM Sporulation and spore germination
B657_RS15000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B657_RS15005	COG1846	Transcriptional regulator
B657_RS15010	COG2197	response regulator
B657_RS15015	COG0824	Thioesterase
B657_RS15020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B657_RS15025	COG1053	succinate dehydrogenase
B657_RS15030	COG2009	succinate dehydrogenase
B657_RS15040	COG1719	4-vinyl reductase, 4VR
B657_RS15045	COG0527	aspartate kinase activity
B657_RS15050	COG0322	excinuclease ABC activity
B657_RS15055	COG3118	belongs to the thioredoxin family
B657_RS15060	COG3534	alpha-L-arabinofuranosidase
B657_RS15065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B657_RS15070	COG2086	electron transfer activity
B657_RS15075	COG1024	Enoyl-CoA hydratase
B657_RS15080	COG1309	transcriptional regulator
B657_RS15085	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS15090	COG3766	membrane
B657_RS15095	COG1193	negative regulation of DNA recombination
B657_RS15100	COG1796	DNA polymerase
B657_RS15100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B657_RS15105	COG1286	toxin biosynthetic process
B657_RS15110	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B657_RS15115	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B657_RS15120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_RS15120	COG0072	phenylalanine-tRNA ligase activity
B657_RS15125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B657_RS15135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B657_RS15145	COG3835	regulator
B657_RS15150	COG0277	FAD linked oxidase domain protein
B657_RS15155	COG0247	lactate metabolic process
B657_RS15160	COG0346	lactoylglutathione lyase activity
B657_RS15170	COG1966	Carbon starvation protein
B657_RS15175	COG3534	alpha-L-arabinofuranosidase
B657_RS15180	COG0395	ABC-type sugar transport system, permease component
B657_RS15185	COG1175	transmembrane transport
B657_RS15190	COG1653	transport
B657_RS15195	COG0371	Dehydrogenase
B657_RS15200	COG0647	UMP catabolic process
B657_RS15205	COG0235	Class ii aldolase
B657_RS15210	COG1069	ribulokinase activity
B657_RS15215	COG2160	L-arabinose isomerase activity
B657_RS15220	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_RS15225	COG1363	Peptidase, m42
B657_RS15235	COG3326	Membrane
B657_RS15240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B657_RS15245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B657_RS15250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B657_RS15260	COG1346	cytolysis
B657_RS15265	COG1380	Effector of murein hydrolase LrgA
B657_RS15270	COG3279	Response regulator of the LytR AlgR family
B657_RS15275	COG3275	phosphorelay sensor kinase activity
B657_RS15280	COG1011	Hydrolase
B657_RS15285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B657_RS15295	COG0398	Pfam SNARE associated Golgi protein
B657_RS15300	COG1484	DNA-dependent DNA replication
B657_RS15305	COG3611	Membrane attachment protein
B657_RS15310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B657_RS15315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B657_RS15320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B657_RS15325	COG1733	regulation of RNA biosynthetic process
B657_RS15330	COG2814	Major facilitator Superfamily
B657_RS15335	COG0656	L-ascorbic acid biosynthetic process
B657_RS15340	COG0237	dephospho-CoA kinase activity
B657_RS15355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B657_RS15360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_RS15360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_RS15365	COG5002	protein histidine kinase activity
B657_RS15370	COG0745	RESPONSE REGULATOR receiver
B657_RS15375	COG0039	L-malate dehydrogenase activity
B657_RS15380	COG0538	isocitrate dehydrogenase activity
B657_RS15385	COG0372	Belongs to the citrate synthase family
B657_RS15390	COG2707	UPF0756 membrane protein
B657_RS15395	COG0628	permease
B657_RS15400	COG3030	protein affecting phage T7 exclusion by the F plasmid
B657_RS15405	COG0469	pyruvate kinase activity
B657_RS15410	COG0205	6-phosphofructokinase activity
B657_RS15415	COG0825	malonyl-CoA metabolic process
B657_RS15420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B657_RS15425	COG0281	malic enzyme
B657_RS15430	COG0587	DNA-directed DNA polymerase activity
B657_RS15450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B657_RS15460	COG4109	DRTGG domain
B657_RS15470	COG0730	response to heat
B657_RS15475	COG1473	amidohydrolase
B657_RS15480	COG0196	riboflavin kinase activity
B657_RS15485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS15490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B657_RS15495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS15500	COG1126	abc transporter atp-binding protein
B657_RS15505	COG0765	amino acid transport
B657_RS15510	COG0765	amino acid transport
B657_RS15515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS15525	COG0454	-acetyltransferase
B657_RS15530	COG0583	DNA-binding transcription factor activity
B657_RS15535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B657_RS15540	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS15550	COG0165	Argininosuccinate lyase
B657_RS15555	COG0137	argininosuccinate synthase activity
B657_RS15560	COG0521	Mo-molybdopterin cofactor biosynthetic process
B657_RS15565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B657_RS15570	COG0827	DNA restriction-modification system
B657_RS15575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B657_RS15580	COG3874	Sporulation protein YtfJ
B657_RS15590	COG1714	RDD family
B657_RS15595	COG0616	signal peptide processing
B657_RS15600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B657_RS15605	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B657_RS15610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B657_RS15620	COG0301	tRNA thio-modification
B657_RS15625	COG1104	cysteine desulfurase activity
B657_RS15630	COG1114	Component of the transport system for branched-chain amino acids
B657_RS15635	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B657_RS15640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B657_RS15645	COG1309	transcriptional regulator
B657_RS15650	COG1956	GAF domain-containing protein
B657_RS15655	COG2199	diguanylate cyclase activity
B657_RS15655	COG2203	Gaf domain
B657_RS15660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B657_RS15670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B657_RS15675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B657_RS15680	COG0454	-acetyltransferase
B657_RS15685	COG0517	IMP dehydrogenase activity
B657_RS15690	COG0123	including yeast histone deacetylase and acetoin utilization protein
B657_RS15695	COG1360	Flagellar Motor Protein
B657_RS15700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B657_RS15705	COG1609	Transcriptional regulator
B657_RS15710	COG1605	Chorismate mutase
B657_RS15710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B657_RS15715	COG3118	belongs to the thioredoxin family
B657_RS15720	COG4980	gas vesicle protein
B657_RS15725	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B657_RS15730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B657_RS15735	COG1674	ftsk spoiiie
B657_RS15740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_RS15745	COG4848	Belongs to the UPF0354 family
B657_RS15750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS15760	COG1363	Peptidase, m42
B657_RS15765	COG5584	Small secreted protein
B657_RS15770	COG0281	malic enzyme
B657_RS15775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS15780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B657_RS15790	COG0510	thiamine kinase activity
B657_RS15795	COG1523	belongs to the glycosyl hydrolase 13 family
B657_RS15800	COG1597	lipid kinase activity
B657_RS15810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B657_RS15815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_RS15820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_RS15825	COG2252	PERMEase
B657_RS15830	COG4473	ABC transporter
B657_RS15835	COG1131	(ABC) transporter
B657_RS15840	COG1349	DNA-binding transcription factor activity
B657_RS15845	COG1187	pseudouridine synthase activity
B657_RS15850	COG2244	polysaccharide biosynthetic process
B657_RS15855	COG2081	HI0933 family
B657_RS15860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B657_RS15870	COG5578	integral membrane protein
B657_RS15875	COG0673	inositol 2-dehydrogenase activity
B657_RS15880	COG1653	transport
B657_RS15885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B657_RS15890	COG4209	transmembrane transport
B657_RS15895	COG2207	Transcriptional regulator
B657_RS15900	COG1653	transport
B657_RS15905	COG0395	ABC-type sugar transport system, permease component
B657_RS15910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_RS15915	COG2124	cytochrome p450
B657_RS15920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B657_RS15925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B657_RS15930	COG0156	8-amino-7-oxononanoate synthase activity
B657_RS15935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_RS15940	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B657_RS15945	COG1073	alpha beta
B657_RS15950	COG1609	Transcriptional regulator
B657_RS15955	COG1653	transport
B657_RS15960	COG1175	transmembrane transport
B657_RS15965	COG0395	ABC-type sugar transport system, permease component
B657_RS15970	COG1486	melibiose metabolic process
B657_RS15975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_RS15980	COG0495	leucyl-tRNA aminoacylation
B657_RS15990	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_RS15990	COG2202	Pas domain
B657_RS15995	COG2814	Major facilitator Superfamily
B657_RS16000	COG2433	Pfam Transposase IS66
B657_RS16005	COG0577	efflux transmembrane transporter activity
B657_RS16010	COG1136	(ABC) transporter
B657_RS16015	COG2205	protein histidine kinase activity
B657_RS16020	COG0745	RESPONSE REGULATOR receiver
B657_RS16025	COG0577	efflux transmembrane transporter activity
B657_RS16030	COG1136	(ABC) transporter
B657_RS16045	COG1131	(ABC) transporter
B657_RS16050	COG1725	Transcriptional regulator
B657_RS16065	COG1242	4 iron, 4 sulfur cluster binding
B657_RS16070	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B657_RS16080	COG2267	carboxylic ester hydrolase activity
B657_RS16085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B657_RS16090	COG1113	amino acid transport
B657_RS16095	COG0367	asparagine synthase
B657_RS16100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B657_RS16105	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B657_RS16115	COG1506	peptidase
B657_RS16120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B657_RS16125	COG1116	anion transmembrane transporter activity
B657_RS16130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B657_RS16135	COG0494	nUDIX hydrolase
B657_RS16140	COG4824	toxin secretion phage lysis holin
B657_RS16145	COG0783	Belongs to the Dps family
B657_RS16160	COG1854	S-ribosylhomocysteine lyase activity
B657_RS16165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B657_RS16170	COG0288	reversible hydration of carbon dioxide
B657_RS16175	COG0254	rRNA binding
B657_RS16180	COG1271	oxidase subunit
B657_RS16185	COG1294	oxidase, subunit
B657_RS16195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_RS16200	COG1321	iron dependent repressor
B657_RS16200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_RS16205	COG1121	(ABC) transporter
B657_RS16210	COG0803	Belongs to the bacterial solute-binding protein 9 family
B657_RS16215	COG4948	Mandelate Racemase Muconate Lactonizing
B657_RS16220	COG0318	PFAM AMP-dependent synthetase and ligase
B657_RS16225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B657_RS16230	COG0596	Alpha beta hydrolase
B657_RS16235	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B657_RS16240	COG1169	isochorismate synthase
B657_RS16245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_RS16250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_RS16255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_RS16260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_RS16265	COG0438	transferase activity, transferring glycosyl groups
B657_RS16275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_RS16280	COG0438	transferase activity, transferring glycosyl groups
B657_RS16285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_RS16290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B657_RS16295	COG0058	SHG alpha-glucan phosphorylase activity
B657_RS16300	COG0297	glycogen (starch) synthase activity
B657_RS16305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B657_RS16310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B657_RS16315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B657_RS16445	COG3859	Proton-coupled thiamine transporter YuaJ
B657_RS16450	COG1247	-acetyltransferase
B657_RS16455	COG2268	Band 7 protein
B657_RS16460	COG1585	Membrane protein implicated in regulation of membrane protease activity
B657_RS16465	COG2318	DinB family
B657_RS16475	COG1454	alcohol dehydrogenase
B657_RS16480	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS16485	COG1510	regulation of RNA biosynthetic process
B657_RS16495	COG0569	domain protein
B657_RS16500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B657_RS16505	COG4682	membrane
B657_RS16510	COG1705	Flagellar rod assembly protein muramidase FlgJ
B657_RS16515	COG0477	Major facilitator Superfamily
B657_RS16520	COG5553	Cysteine dioxygenase type I
B657_RS16530	COG1968	undecaprenyl-diphosphatase activity
B657_RS16535	COG0628	permease
B657_RS16540	COG0673	inositol 2-dehydrogenase activity
B657_RS16545	COG4806	L-rhamnose isomerase
B657_RS16550	COG3254	rhamnose metabolic process
B657_RS16555	COG1070	Carbohydrate kinase
B657_RS16560	COG1349	DNA-binding transcription factor activity
B657_RS16565	COG3347	Dehydrogenase
B657_RS16565	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS16570	COG0840	transmembrane signaling receptor activity
B657_RS16575	COG0840	transmembrane signaling receptor activity
B657_RS16580	COG0840	transmembrane signaling receptor activity
B657_RS16585	COG0840	transmembrane signaling receptor activity
B657_RS16600	COG0432	Pfam Uncharacterised protein family UPF0047
B657_RS16605	COG0366	Alpha amylase catalytic
B657_RS16610	COG1253	flavin adenine dinucleotide binding
B657_RS16615	COG2738	Putative neutral zinc metallopeptidase
B657_RS16630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B657_RS16645	COG0166	Belongs to the GPI family
B657_RS16650	COG1979	alcohol dehydrogenase
B657_RS16655	COG1979	alcohol dehydrogenase
B657_RS16660	COG2155	Conserved Protein
B657_RS16665	COG1098	S1 RNA binding domain
B657_RS16670	COG0436	Aminotransferase
B657_RS16675	COG1522	sequence-specific DNA binding
B657_RS16680	COG2267	carboxylic ester hydrolase activity
B657_RS16690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B657_RS16695	COG2205	protein histidine kinase activity
B657_RS16705	COG5018	Exonuclease
B657_RS16715	COG2814	Major facilitator Superfamily
B657_RS16720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_RS16725	COG3011	Protein conserved in bacteria
B657_RS16735	COG3290	protein histidine kinase activity
B657_RS16740	COG4565	transcriptional regulatory protein
B657_RS16745	COG1744	ABC transporter substrate-binding protein PnrA-like
B657_RS16750	COG3845	ABC transporter
B657_RS16755	COG4603	Belongs to the binding-protein-dependent transport system permease family
B657_RS16760	COG1079	Belongs to the binding-protein-dependent transport system permease family
B657_RS16765	COG3493	citrate carrier protein
B657_RS16775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B657_RS16775	COG2111	Na H antiporter
B657_RS16780	COG2111	Na H antiporter
B657_RS16785	COG1006	Multisubunit Na H antiporter MnhC subunit
B657_RS16790	COG0651	ATP synthesis coupled electron transport
B657_RS16795	COG1863	multisubunit Na H antiporter MnhE subunit
B657_RS16800	COG2212	antiporter activity
B657_RS16805	COG1320	monovalent cation:proton antiporter activity
B657_RS16810	COG2050	protein possibly involved in aromatic compounds catabolism
B657_RS16815	COG2197	response regulator
B657_RS16820	COG4585	Histidine kinase
B657_RS16830	COG0142	geranyltranstransferase activity
B657_RS16845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B657_RS16850	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B657_RS16855	COG1335	isochorismatase
B657_RS16860	COG5506	Protein of unknown function (DUF1694)
B657_RS16875	COG0628	permease
B657_RS16890	COG1418	mRNA catabolic process
B657_RS16895	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS16905	COG1511	domain protein
B657_RS16910	COG1674	ftsk spoiiie
B657_RS16910	COG0433	COG0433 Predicted ATPase
B657_RS16915	COG4499	WXG100 protein secretion system (Wss), protein YukC
B657_RS16920	COG5417	Belongs to the EsaB family
B657_RS16925	COG4842	Belongs to the WXG100 family
B657_RS16930	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B657_RS16930	COG2508	Transcriptional regulator
B657_RS16935	COG0686	Belongs to the AlaDH PNT family
B657_RS16940	COG5634	Uncharacterized conserved protein (DUF2278)
B657_RS16945	COG3251	PFAM MbtH domain protein
B657_RS16950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS16955	COG3433	isochorismatase activity
B657_RS16955	COG1535	isochorismatase
B657_RS16960	COG1021	2,3-dihydroxybenzoate-AMP ligase
B657_RS16965	COG1169	isochorismate synthase
B657_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS16975	COG2819	hydrolase of the alpha beta superfamily
B657_RS16980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B657_RS16985	COG1268	BioY protein
B657_RS16990	COG2056	Na+-H+ antiporter family
B657_RS16995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B657_RS17000	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B657_RS17005	COG3584	3D domain protein
B657_RS17020	COG1252	NADH dehydrogenase
B657_RS17025	COG0492	ferredoxin-NADP+ reductase activity
B657_RS17035	COG0516	GMP reductase activity
B657_RS17040	COG2808	Putative FMN-binding domain
B657_RS17045	COG0456	acetyltransferase
B657_RS17050	COG0316	Belongs to the HesB IscA family
B657_RS17055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B657_RS17065	COG4844	belongs to the
B657_RS17070	COG1252	NADH dehydrogenase
B657_RS17075	COG4837	Protein of unknown function (DUF1462)
B657_RS17080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B657_RS17085	COG0823	Involved in the tonB-independent uptake of proteins
B657_RS17085	COG4946	Tricorn protease homolog
B657_RS17085	COG1506	peptidase
B657_RS17090	COG0083	homoserine kinase activity
B657_RS17095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B657_RS17100	COG0460	homoserine dehydrogenase
B657_RS17105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_RS17110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B657_RS17115	COG0647	UMP catabolic process
B657_RS17120	COG2445	Protein of unknown function DUF86
B657_RS17125	COG4470	Protein conserved in bacteria
B657_RS17135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B657_RS17140	COG0739	heme binding
B657_RS17150	COG3377	Domain of unknown function (DUF1805)
B657_RS17155	COG0737	Belongs to the 5'-nucleotidase family
B657_RS17160	COG0730	response to heat
B657_RS17165	COG1801	Protein of unknown function DUF72
B657_RS17175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B657_RS17180	COG2508	Transcriptional regulator
B657_RS17185	COG2233	PERMEase
B657_RS17190	COG2233	PERMEase
B657_RS17195	COG3195	allantoin biosynthetic process
B657_RS17195	COG3648	Uricase
B657_RS17200	COG2351	hydroxyisourate hydrolase activity
B657_RS17210	COG2080	2 iron, 2 sulfur cluster binding
B657_RS17215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B657_RS17220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B657_RS17225	COG2068	MobA-Related Protein
B657_RS17230	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B657_RS17235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B657_RS17240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_RS17250	COG2356	endonuclease I
B657_RS17255	COG3842	ATPase activity
B657_RS17260	COG2188	Transcriptional regulator
B657_RS17265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_RS17270	COG0395	ABC-type sugar transport system, permease component
B657_RS17275	COG1175	transmembrane transport
B657_RS17280	COG1653	transport
B657_RS17285	COG2222	sugar isomerase
B657_RS17290	COG0322	excinuclease ABC activity
B657_RS17295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_RS17310	COG0346	lactoylglutathione lyase activity
B657_RS17315	COG0640	Transcriptional regulator
B657_RS17320	COG0719	Fe-S assembly protein
B657_RS17325	COG0822	iron-sulfur transferase activity
B657_RS17330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B657_RS17335	COG0719	Fe-S assembly protein
B657_RS17340	COG0396	ATPase activity
B657_RS17350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B657_RS17355	COG1464	Belongs to the NlpA lipoprotein family
B657_RS17360	COG2011	ABC-type metal ion transport system permease component
B657_RS17365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B657_RS17375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_RS17380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B657_RS17390	COG0509	glycine decarboxylation via glycine cleavage system
B657_RS17395	COG1393	Belongs to the ArsC family
B657_RS17400	COG1960	acyl-CoA dehydrogenase activity
B657_RS17405	COG0183	Belongs to the thiolase family
B657_RS17410	COG1024	Enoyl-CoA hydratase
B657_RS17410	COG1250	3-hydroxyacyl-CoA dehydrogenase
B657_RS17420	COG0506	proline dehydrogenase activity
B657_RS17430	COG5577	PFAM Coat F domain
B657_RS17435	COG1846	Transcriptional regulator
B657_RS17440	COG0477	Major facilitator Superfamily
B657_RS17445	COG1942	4-Oxalocrotonate Tautomerase
B657_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS17455	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS17460	COG0583	DNA-binding transcription factor activity
B657_RS17470	COG1120	ATPase activity
B657_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS17495	COG0783	Belongs to the Dps family
B657_RS17500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_RS17505	COG0745	RESPONSE REGULATOR receiver
B657_RS17510	COG2770	Histidine kinase
B657_RS17510	COG2205	protein histidine kinase activity
B657_RS17520	COG1309	transcriptional regulator
B657_RS17525	COG0114	fumarate hydratase activity
B657_RS17535	COG0697	spore germination
B657_RS17540	COG0814	amino acid
B657_RS17550	COG2197	response regulator
B657_RS17555	COG4585	Histidine kinase
B657_RS17560	COG4758	membrane
B657_RS17565	COG3595	metallopeptidase activity
B657_RS17570	COG1842	Phage shock protein A
B657_RS17575	COG4758	membrane
B657_RS17580	COG2814	Major facilitator Superfamily
B657_RS17585	COG2096	Adenosyltransferase
B657_RS17590	COG1120	ATPase activity
B657_RS17595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS17600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS17615	COG3386	PFAM SMP-30 Gluconolaconase
B657_RS17620	COG2205	protein histidine kinase activity
B657_RS17625	COG0745	RESPONSE REGULATOR receiver
B657_RS17635	COG1191	sigma factor activity
B657_RS17645	COG2140	Oxalate decarboxylase
B657_RS17655	COG0577	efflux transmembrane transporter activity
B657_RS17660	COG1136	(ABC) transporter
B657_RS17665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B657_RS17670	COG1120	ATPase activity
B657_RS17675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS17680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_RS17685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS17695	COG0531	amino acid
B657_RS17705	COG1988	membrane-bound metal-dependent
B657_RS17710	COG1368	sulfuric ester hydrolase activity
B657_RS17715	COG1910	domain protein
B657_RS17720	COG0725	ABC transporter, periplasmic molybdate-binding protein
B657_RS17725	COG4149	molybdate abc transporter
B657_RS17730	COG0656	L-ascorbic acid biosynthetic process
B657_RS17740	COG0025	NhaP-type Na H and K H
B657_RS17745	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_RS17750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_RS17755	COG3973	AAA domain
B657_RS17760	COG2860	membrane
B657_RS17765	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B657_RS17770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B657_RS17775	COG2217	Heavy metal translocating P-type atpase
B657_RS17780	COG2217	Heavy metal translocating P-type atpase
B657_RS17785	COG2608	mercury ion transmembrane transporter activity
B657_RS17790	COG1937	Protein conserved in bacteria
B657_RS17795	COG0673	inositol 2-dehydrogenase activity
B657_RS17800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B657_RS17805	COG1289	transmembrane transporter activity
B657_RS17815	COG2076	Multidrug Resistance protein
B657_RS17820	COG1309	transcriptional regulator
B657_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS17830	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B657_RS17835	COG0557	exoribonuclease II activity
B657_RS17840	COG1647	Serine aminopeptidase, S33
B657_RS17845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B657_RS17850	COG0596	Alpha beta hydrolase
B657_RS17855	COG1476	TRANSCRIPTIONal
B657_RS17860	COG1396	sequence-specific DNA binding
B657_RS17865	COG1396	sequence-specific DNA binding
B657_RS17870	COG1733	regulation of RNA biosynthetic process
B657_RS17875	COG0840	transmembrane signaling receptor activity
B657_RS17880	COG1174	glycine betaine transport
B657_RS17885	COG1732	Glycine betaine
B657_RS17890	COG1174	glycine betaine transport
B657_RS17895	COG1125	glycine betaine transport
B657_RS17895	COG0517	IMP dehydrogenase activity
B657_RS17900	COG1510	regulation of RNA biosynthetic process
B657_RS17920	COG5658	integral membrane protein
B657_RS17925	COG0640	Transcriptional regulator
B657_RS17930	COG1174	glycine betaine transport
B657_RS17935	COG1732	Glycine betaine
B657_RS17940	COG1174	glycine betaine transport
B657_RS17945	COG0517	IMP dehydrogenase activity
B657_RS17945	COG1125	glycine betaine transport
B657_RS17950	COG1510	regulation of RNA biosynthetic process
B657_RS17955	COG2095	MarC family integral membrane protein
B657_RS17965	COG3064	Membrane
B657_RS17970	COG4640	response to antibiotic
B657_RS17975	COG0456	acetyltransferase
B657_RS17980	COG0148	phosphopyruvate hydratase activity
B657_RS17985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B657_RS17990	COG0149	triose-phosphate isomerase activity
B657_RS17995	COG0126	phosphoglycerate kinase activity
B657_RS18005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B657_RS18010	COG2390	Transcriptional regulator
B657_RS18015	COG2814	Major facilitator Superfamily
B657_RS18020	COG1609	Transcriptional regulator
B657_RS18025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS18030	COG0583	DNA-binding transcription factor activity
B657_RS18035	COG0697	spore germination
B657_RS18040	COG1113	amino acid transport
B657_RS18045	COG3858	chitin binding
B657_RS18050	COG1556	Lactate utilization protein
B657_RS18055	COG1139	Iron-sulfur cluster binding protein
B657_RS18060	COG0247	lactate metabolic process
B657_RS18065	COG2197	response regulator
B657_RS18070	COG4585	Histidine kinase
B657_RS18075	COG0842	Transport permease protein
B657_RS18080	COG1131	(ABC) transporter
B657_RS18085	COG0596	Alpha beta hydrolase
B657_RS18090	COG2208	phosphoserine phosphatase activity
B657_RS18095	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B657_RS18100	COG1874	Beta-galactosidase
B657_RS18105	COG3833	ABC-type maltose transport systems, permease component
B657_RS18110	COG1175	transmembrane transport
B657_RS18115	COG2182	Extracellular solute-binding protein
B657_RS18120	COG1609	Transcriptional regulator
B657_RS18125	COG2186	Transcriptional regulator
B657_RS18130	COG1620	l-lactate permease
B657_RS18135	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B657_RS18145	COG5039	Polysaccharide pyruvyl transferase
B657_RS18150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_RS18155	COG0110	maltose O-acetyltransferase activity
B657_RS18160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B657_RS18165	COG2244	polysaccharide biosynthetic process
B657_RS18170	COG1216	Glycosyl transferase, family 2
B657_RS18175	COG5039	Polysaccharide pyruvyl transferase
B657_RS18180	COG1216	Glycosyl transferase, family 2
B657_RS18190	COG0438	transferase activity, transferring glycosyl groups
B657_RS18195	COG1215	transferase activity, transferring glycosyl groups
B657_RS18200	COG0438	transferase activity, transferring glycosyl groups
B657_RS18205	COG1086	Polysaccharide biosynthesis protein
B657_RS18210	COG0489	protein tyrosine kinase activity
B657_RS18215	COG3944	biosynthesis protein
B657_RS18220	COG1396	sequence-specific DNA binding
B657_RS18225	COG2272	Belongs to the type-B carboxylesterase lipase family
B657_RS18235	COG3479	Phenolic acid decarboxylase
B657_RS18245	COG1794	racemase activity, acting on amino acids and derivatives
B657_RS18250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_RS18255	COG1621	beta-fructofuranosidase activity
B657_RS18260	COG1621	beta-fructofuranosidase activity
B657_RS18265	COG0531	amino acid
B657_RS18270	COG1309	transcriptional regulator
B657_RS18275	COG2076	Multidrug Resistance protein
B657_RS18280	COG2076	Multidrug Resistance protein
B657_RS18290	COG0277	FAD linked oxidase domain protein
B657_RS18295	COG3621	Patatin-like phospholipase
B657_RS18305	COG0740	serine-type endopeptidase activity
B657_RS18310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B657_RS18315	COG0366	Alpha amylase catalytic
B657_RS18320	COG1554	hydrolase, family 65, central catalytic
B657_RS18325	COG5521	maltodextrose utilization protein MalA
B657_RS18330	COG3833	ABC-type maltose transport systems, permease component
B657_RS18335	COG1175	transmembrane transport
B657_RS18340	COG2182	Extracellular solute-binding protein
B657_RS18345	COG0366	Alpha amylase catalytic
B657_RS18350	COG1609	Transcriptional regulator
B657_RS18355	COG1611	Belongs to the LOG family
B657_RS18360	COG1694	Mazg nucleotide pyrophosphohydrolase
B657_RS18365	COG0659	secondary active sulfate transmembrane transporter activity
B657_RS18370	COG0288	reversible hydration of carbon dioxide
B657_RS18375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B657_RS18380	COG0577	efflux transmembrane transporter activity
B657_RS18385	COG1136	(ABC) transporter
B657_RS18390	COG5002	protein histidine kinase activity
B657_RS18395	COG0745	RESPONSE REGULATOR receiver
B657_RS18405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B657_RS18410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS18415	COG1481	regulation of sporulation
B657_RS18420	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B657_RS18425	COG1660	Displays ATPase and GTPase activities
B657_RS18430	COG1051	belongs to the nudix hydrolase family
B657_RS18435	COG0492	ferredoxin-NADP+ reductase activity
B657_RS18440	COG0791	NLP P60 protein
B657_RS18440	COG3883	PFAM NLP P60 protein
B657_RS18445	COG0457	Tetratricopeptide repeat
B657_RS18450	COG1132	(ABC) transporter
B657_RS18470	COG0140	phosphoribosyl-ATP diphosphatase activity
B657_RS18470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B657_RS18475	COG0107	imidazoleglycerol-phosphate synthase activity
B657_RS18480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B657_RS18485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B657_RS18490	COG0131	Imidazoleglycerol-phosphate dehydratase
B657_RS18495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B657_RS18500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B657_RS18505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B657_RS18510	COG4990	cell redox homeostasis
B657_RS18515	COG5297	Belongs to the glycosyl hydrolase family 6
B657_RS18520	COG0110	maltose O-acetyltransferase activity
B657_RS18525	COG0546	phosphoglycolate phosphatase activity
B657_RS18530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B657_RS18535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B657_RS18540	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B657_RS18545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B657_RS18550	COG0363	glucosamine-6-phosphate deaminase activity
B657_RS18555	COG2188	Transcriptional regulator
B657_RS18560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_RS18565	COG1846	Transcriptional regulator
B657_RS18570	COG2124	cytochrome p450
B657_RS18580	COG1846	Transcriptional regulator
B657_RS18585	COG2814	Major facilitator Superfamily
B657_RS18590	COG1950	PFAM Membrane protein of
B657_RS18595	COG1983	PspC domain protein
B657_RS18600	COG3595	metallopeptidase activity
B657_RS18615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_RS18620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B657_RS18625	COG0556	nucleotide-excision repair
B657_RS18630	COG4897	Protein conserved in bacteria
B657_RS18635	COG3848	Pyruvate phosphate dikinase
B657_RS18635	COG0574	Belongs to the PEP-utilizing enzyme family
B657_RS18640	COG1309	transcriptional regulator
B657_RS18645	COG2814	Major facilitator Superfamily
B657_RS18650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_RS18660	COG3409	Peptidoglycan-binding domain 1 protein
B657_RS18660	COG0793	Belongs to the peptidase S41A family
B657_RS18665	COG2177	Part of the ABC transporter FtsEX involved in
B657_RS18670	COG2884	Cell division ATP-binding protein ftsE
B657_RS18675	COG2010	Cytochrome c
B657_RS18680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS18685	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B657_RS18690	COG0653	protein targeting
B657_RS18695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B657_RS18710	COG1516	flagellar protein fliS
B657_RS18715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B657_RS18720	COG1334	flagellar protein FlaG
B657_RS18725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_RS18730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B657_RS18735	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B657_RS18745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_RS18750	COG1256	bacterial-type flagellum assembly
B657_RS18750	COG4786	Flagellar basal body rod
B657_RS18755	COG3418	PFAM FlgN family protein
B657_RS18760	COG2747	anti-sigma28 factor FlgM
B657_RS18770	COG1040	competence protein
B657_RS18780	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B657_RS18785	COG1307	EDD domain protein, DegV family
B657_RS18790	COG2197	response regulator
B657_RS18795	COG4585	Histidine kinase
B657_RS18800	COG1739	Uncharacterized protein family UPF0029
B657_RS18805	COG1316	TRANSCRIPTIONal
B657_RS18810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B657_RS18815	COG0438	transferase activity, transferring glycosyl groups
B657_RS18820	COG1215	transferase activity, transferring glycosyl groups
B657_RS18825	COG3206	protein involved in exopolysaccharide biosynthesis
B657_RS18830	COG3307	-O-antigen
B657_RS18835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_RS18840	COG0297	glycogen (starch) synthase activity
B657_RS18840	COG0438	transferase activity, transferring glycosyl groups
B657_RS18845	COG2244	polysaccharide biosynthetic process
B657_RS18850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B657_RS18860	COG2247	cell wall binding repeat
B657_RS18860	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_RS18865	COG2247	cell wall binding repeat
B657_RS18865	COG2385	sporulation resulting in formation of a cellular spore
B657_RS18875	COG1316	TRANSCRIPTIONal
B657_RS18880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B657_RS18885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_RS18890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_RS18890	COG1215	transferase activity, transferring glycosyl groups
B657_RS18895	COG0463	Glycosyl transferase, family 2
B657_RS18910	COG1134	teichoic acid transport
B657_RS18915	COG1682	transport, permease protein
B657_RS18920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_RS18925	COG0438	transferase activity, transferring glycosyl groups
B657_RS18930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B657_RS18935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B657_RS18940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_RS18950	COG4193	domain, Protein
B657_RS18955	COG1482	cell wall glycoprotein biosynthetic process
B657_RS18965	COG0697	spore germination
B657_RS18970	COG0814	amino acid
B657_RS18980	COG2814	Major facilitator Superfamily
B657_RS18985	COG1316	TRANSCRIPTIONal
B657_RS18990	COG0561	phosphatase activity
B657_RS18995	COG0791	NLP P60 protein
B657_RS19005	COG2843	Capsule synthesis protein
B657_RS19015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B657_RS19020	COG1609	Transcriptional regulator
B657_RS19025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_RS19030	COG1869	D-ribose catabolic process
B657_RS19035	COG1129	ABC transporter
B657_RS19040	COG1172	Belongs to the binding-protein-dependent transport system permease family
B657_RS19045	COG1879	ABC-type sugar transport system periplasmic component
B657_RS19050	COG3103	Sh3 type 3 domain protein
B657_RS19060	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_RS19065	COG3527	Alpha-acetolactate decarboxylase
B657_RS19070	COG0028	Belongs to the TPP enzyme family
B657_RS19075	COG0583	DNA-binding transcription factor activity
B657_RS19080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B657_RS19095	COG5337	Spore coat protein CotH
B657_RS19105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B657_RS19115	COG0405	Gamma-glutamyltransferase
B657_RS19120	COG1522	sequence-specific DNA binding
B657_RS19125	COG2059	Chromate
B657_RS19130	COG2059	Chromate
B657_RS19140	COG0655	NAD(P)H dehydrogenase (quinone) activity
B657_RS19145	COG0583	DNA-binding transcription factor activity
B657_RS19150	COG1515	deoxyribonuclease V activity
B657_RS19155	COG2849	repeat protein
B657_RS19160	COG5444	nuclease activity
B657_RS19175	COG3878	Protein conserved in bacteria
B657_RS19180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_RS19185	COG4464	protein tyrosine phosphatase activity
B657_RS19190	COG0489	protein tyrosine kinase activity
B657_RS19195	COG3944	biosynthesis protein
B657_RS19205	COG4715	Zinc finger, swim domain protein
B657_RS19210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B657_RS19215	COG0561	phosphatase activity
B657_RS19220	COG1349	DNA-binding transcription factor activity
B657_RS19225	COG0629	single-stranded DNA binding
B657_RS19240	COG3764	Sortase (surface protein transpeptidase)
B657_RS19245	COG2972	Histidine kinase
B657_RS19245	COG0745	RESPONSE REGULATOR receiver
B657_RS19250	COG1970	mechanosensitive ion channel activity
B657_RS19255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B657_RS19260	COG0457	Tetratricopeptide repeat
B657_RS19265	COG4786	Flagellar basal body rod
B657_RS19270	COG4786	Flagellar basal body rod
B657_RS19275	COG1077	Cell shape determining protein MreB Mrl
B657_RS19280	COG1609	Transcriptional regulator
B657_RS19285	COG1846	Transcriptional regulator
B657_RS19290	COG2814	Major facilitator Superfamily
B657_RS19295	COG3420	alginic acid biosynthetic process
B657_RS19300	COG1953	Uracil, thiamine, allantoin
B657_RS19305	COG0477	Major facilitator Superfamily
B657_RS19310	COG1335	isochorismatase
B657_RS19320	COG0004	ammonium transporteR
B657_RS19325	COG0347	Belongs to the P(II) protein family
B657_RS19330	COG0671	phosphoesterase, PA-phosphatase related
B657_RS19340	COG0739	heme binding
B657_RS19345	COG1247	-acetyltransferase
B657_RS19365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_RS19370	COG0789	Transcriptional regulator
B657_RS19380	COG2910	NAD(P)H-binding
B657_RS19385	COG1959	2 iron, 2 sulfur cluster binding
B657_RS19390	COG0804	urea catabolic process
B657_RS19395	COG0832	Belongs to the urease beta subunit family
B657_RS19400	COG0831	urea catabolic process
B657_RS19410	COG3237	CsbD-like
B657_RS19415	COG1994	Peptidase M50
B657_RS19420	COG0457	Tetratricopeptide repeat
B657_RS19425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B657_RS19430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B657_RS19440	COG2304	oxidoreductase activity
B657_RS19450	COG2304	oxidoreductase activity
B657_RS19455	COG2385	sporulation resulting in formation of a cellular spore
B657_RS19460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B657_RS19470	COG4836	Membrane
B657_RS19480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B657_RS19485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B657_RS19490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B657_RS19495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B657_RS19500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B657_RS19505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B657_RS19530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B657_RS19535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B657_RS19540	COG4475	Protein of unknown function (DUF436)
B657_RS19545	COG0698	ribose 5-phosphate isomerase
B657_RS19550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B657_RS19555	COG1971	Probably functions as a manganese efflux pump
B657_RS19560	COG0009	L-threonylcarbamoyladenylate synthase
B657_RS19565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B657_RS19585	COG2890	protein-(glutamine-N5) methyltransferase activity
B657_RS19590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B657_RS19595	COG0346	lactoylglutathione lyase activity
B657_RS19600	COG0789	Transcriptional regulator
B657_RS19605	COG0679	Auxin Efflux Carrier
B657_RS19610	COG0281	malic enzyme
B657_RS19615	COG1435	thymidine kinase activity
B657_RS19625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B657_RS19635	COG1494	fructose-1,6-bisphosphatase
B657_RS19640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B657_RS19645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B657_RS19650	COG0191	fructose-bisphosphate aldolase activity
B657_RS19655	COG2204	response regulator
B657_RS19660	COG4821	SIS domain
B657_RS19665	COG0504	CTP synthase activity
B657_RS19670	COG3343	RNA polymerase activity
B657_RS19675	COG1960	acyl-CoA dehydrogenase activity
B657_RS19680	COG0247	lactate metabolic process
B657_RS19680	COG2181	nitrate reductase activity
B657_RS19685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_RS19690	COG4294	response to UV
B657_RS19700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_RS19705	COG1132	(ABC) transporter
B657_RS19710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_RS19715	COG2181	nitrate reductase activity
B657_RS19720	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B657_RS19725	COG1140	nitrate reductase beta subunit
B657_RS19730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B657_RS19735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B657_RS19745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B657_RS19750	COG2223	nitrite transmembrane transporter activity
B657_RS19755	COG0018	arginyl-trna synthetase
B657_RS19760	COG4506	Protein conserved in bacteria
B657_RS19770	COG0535	radical SAM domain protein
B657_RS19780	COG1131	(ABC) transporter
B657_RS19785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B657_RS19790	COG0612	Peptidase, M16
B657_RS19795	COG0612	Peptidase, M16
B657_RS19805	COG3391	amine dehydrogenase activity
B657_RS19810	COG3391	amine dehydrogenase activity
B657_RS19820	COG0457	Tetratricopeptide repeat
B657_RS19830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B657_RS19835	COG0010	Belongs to the arginase family
B657_RS19840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B657_RS19845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_RS19855	COG1994	Peptidase M50
B657_RS19860	COG1942	4-Oxalocrotonate Tautomerase
B657_RS19865	COG1846	Transcriptional regulator
B657_RS19870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B657_RS19880	COG0477	Major facilitator Superfamily
B657_RS19885	COG1959	2 iron, 2 sulfur cluster binding
B657_RS19890	COG3465	dGTPase activity
B657_RS19895	COG1078	dGTPase activity
B657_RS19900	COG4844	belongs to the
B657_RS19910	COG0697	spore germination
B657_RS19915	COG0095	Lipoate-protein ligase
B657_RS19920	COG0583	DNA-binding transcription factor activity
B657_RS19925	COG0280	phosphate acetyltransferase
B657_RS19930	COG3253	May function as heme-dependent peroxidase
B657_RS19935	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS19940	COG0436	Aminotransferase
B657_RS19945	COG2814	Major facilitator Superfamily
B657_RS19950	COG0151	Belongs to the GarS family
B657_RS19955	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS19960	COG1917	Cupin 2, conserved barrel domain protein
B657_RS19965	COG0077	Prephenate dehydratase
B657_RS19970	COG2814	Major facilitator Superfamily
B657_RS19975	COG0833	amino acid
B657_RS19980	COG4187	Peptidase family M20/M25/M40
B657_RS19985	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS19990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_RS20000	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B657_RS20005	COG1091	dTDP-4-dehydrorhamnose reductase activity
B657_RS20010	COG1088	dTDP-glucose 4,6-dehydratase activity
B657_RS20015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B657_RS20020	COG3980	spore coat polysaccharide biosynthesis protein
B657_RS20025	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B657_RS20030	COG2089	acid synthase
B657_RS20035	COG0456	acetyltransferase
B657_RS20040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_RS20045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_RS20050	COG0463	Glycosyl transferase, family 2
B657_RS20065	COG2363	Small membrane protein
B657_RS20070	COG2233	PERMEase
B657_RS20080	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS20085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B657_RS20090	COG1216	Glycosyl transferase, family 2
B657_RS20105	COG1695	Transcriptional regulator
B657_RS20110	COG0351	phosphomethylpyrimidine kinase
B657_RS20120	COG1621	beta-fructofuranosidase activity
B657_RS20125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS20125	COG1263	PTS System
B657_RS20130	COG2116	formate transmembrane transporter activity
B657_RS20135	COG3711	transcriptional antiterminator
B657_RS20145	COG1404	Belongs to the peptidase S8 family
B657_RS20150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS20155	COG0778	Nitroreductase
B657_RS20160	COG0772	Belongs to the SEDS family
B657_RS20170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B657_RS20175	COG1845	cytochrome c oxidase, subunit III
B657_RS20180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B657_RS20185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B657_RS20190	COG2261	transglycosylase associated protein
B657_RS20195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B657_RS20200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B657_RS20205	COG2246	polysaccharide biosynthetic process
B657_RS20210	COG1309	transcriptional regulator
B657_RS20220	COG3162	membrane
B657_RS20225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_RS20230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B657_RS20235	COG2837	iron assimilation
B657_RS20240	COG2822	iron ion transport
B657_RS20245	COG0672	)-iron permease
B657_RS20250	COG0352	thiamine-phosphate diphosphorylase activity
B657_RS20255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B657_RS20260	COG0583	DNA-binding transcription factor activity
B657_RS20265	COG1380	Effector of murein hydrolase LrgA
B657_RS20270	COG1346	cytolysis
B657_RS20275	COG2814	Major facilitator Superfamily
B657_RS20280	COG4895	conserved protein (DUF2196)
B657_RS20285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B657_RS20290	COG0346	lactoylglutathione lyase activity
B657_RS20300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_RS20305	COG1404	Belongs to the peptidase S8 family
B657_RS20310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS20310	COG1263	PTS System
B657_RS20315	COG3711	transcriptional antiterminator
B657_RS20320	COG1442	glycosyl transferase family 8
B657_RS20325	COG5522	Integral membrane protein (intg_mem_TP0381)
B657_RS20330	COG1846	Transcriptional regulator
B657_RS20335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B657_RS20340	COG2234	aminopeptidase activity
B657_RS20345	COG2357	RelA SpoT domain protein
B657_RS20350	COG1575	Belongs to the MenA family. Type 1 subfamily
B657_RS20365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_RS20370	COG1696	Membrane protein involved in D-alanine export
B657_RS20375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_RS20380	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B657_RS20385	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B657_RS20390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_RS20395	COG1486	melibiose metabolic process
B657_RS20400	COG1447	Phosphotransferase system cellobiose-specific component IIA
B657_RS20405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_RS20410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_RS20415	COG3711	transcriptional antiterminator
B657_RS20415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_RS20425	COG2094	Belongs to the DNA glycosylase MPG family
B657_RS20430	COG0753	catalase activity
B657_RS20435	COG2814	Major facilitator Superfamily
B657_RS20440	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_RS20445	COG1131	(ABC) transporter
B657_RS20465	COG1595	DNA-templated transcription, initiation
B657_RS20470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B657_RS20475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B657_RS20480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B657_RS20485	COG4988	ABC transporter
B657_RS20490	COG1294	oxidase, subunit
B657_RS20495	COG1271	oxidase subunit
B657_RS20500	COG3493	citrate carrier protein
B657_RS20505	COG0501	Belongs to the peptidase M48B family
B657_RS20515	COG0726	polysaccharide deacetylase
B657_RS20520	COG3842	ATPase activity
B657_RS20525	COG2508	Transcriptional regulator
B657_RS20530	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS20535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_RS20545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B657_RS20550	COG1881	PFAM PEBP family protein
B657_RS20555	COG0583	DNA-binding transcription factor activity
B657_RS20565	COG4585	Histidine kinase
B657_RS20570	COG2197	response regulator
B657_RS20575	COG2195	Cleaves the N-terminal amino acid of tripeptides
B657_RS20590	COG4894	glucomannan catabolic process
B657_RS20595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_RS20600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_RS20605	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS20610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B657_RS20615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B657_RS20620	COG2610	gluconate transmembrane transporter activity
B657_RS20630	COG0500	methyltransferase
B657_RS20635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B657_RS20655	COG0753	catalase activity
B657_RS20655	COG0693	protein deglycase activity
B657_RS20660	COG2851	Citrate transporter
B657_RS20665	COG2273	Hydrolase Family 16
B657_RS20670	COG3711	transcriptional antiterminator
B657_RS20680	COG2270	Major facilitator Superfamily
B657_RS20685	COG0513	Belongs to the DEAD box helicase family
B657_RS20690	COG2755	lipolytic protein G-D-S-L family
B657_RS20690	COG3401	FG-GAP repeat protein
B657_RS20745	COG3209	COG3209 Rhs family protein
B657_RS20750	COG0697	spore germination
B657_RS20755	COG0589	response to stress
B657_RS20760	COG2723	6-phospho-beta-galactosidase activity
B657_RS20765	COG2190	(PTS) system
B657_RS20765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_RS20765	COG1263	PTS System
B657_RS20780	COG5444	nuclease activity
B657_RS20795	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_RS20810	COG2986	histidine ammonia-lyase
B657_RS20815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B657_RS20820	COG1228	amidohydrolase
B657_RS20825	COG0010	Belongs to the arginase family
B657_RS20830	COG0833	amino acid
B657_RS20835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B657_RS20840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B657_RS20845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B657_RS20850	COG2390	Transcriptional regulator
B657_RS20860	COG3192	ethanolamine utilization protein
B657_RS20865	COG2079	MmgE PrpD family protein
B657_RS20870	COG1473	amidohydrolase
B657_RS20875	COG1126	abc transporter atp-binding protein
B657_RS20880	COG0765	amino acid transport
B657_RS20885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_RS20890	COG0456	acetyltransferase
B657_RS20895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_RS20905	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B657_RS20910	COG0561	phosphatase activity
B657_RS20940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_RS20945	COG5294	Protein conserved in bacteria
B657_RS20950	COG0577	efflux transmembrane transporter activity
B657_RS20955	COG1136	(ABC) transporter
B657_RS20960	COG2205	protein histidine kinase activity
B657_RS20965	COG0745	RESPONSE REGULATOR receiver
B657_RS20970	COG0191	fructose-bisphosphate aldolase activity
B657_RS20975	COG1082	Xylose isomerase domain protein TIM barrel
B657_RS20980	COG1082	Xylose isomerase domain protein TIM barrel
B657_RS20985	COG0673	inositol 2-dehydrogenase activity
B657_RS20990	COG2814	Major facilitator Superfamily
B657_RS20995	COG1082	Xylose isomerase domain protein TIM barrel
B657_RS21000	COG3962	Belongs to the TPP enzyme family
B657_RS21005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_RS21010	COG3718	enzyme involved in inositol metabolism
B657_RS21015	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS21020	COG1349	DNA-binding transcription factor activity
B657_RS21025	COG0667	Aldo Keto reductase
B657_RS21040	COG2814	Major facilitator Superfamily
B657_RS21045	COG0326	Molecular chaperone. Has ATPase activity
B657_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS21060	COG1309	transcriptional regulator
B657_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
B657_RS21070	COG0456	acetyltransferase
B657_RS21075	COG2850	peptidyl-arginine hydroxylation
B657_RS21080	COG2226	methyltransferase
B657_RS21095	COG0367	asparagine synthase
B657_RS21100	COG2814	Major facilitator Superfamily
B657_RS21105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B657_RS21115	COG1714	RDD family
B657_RS21120	COG2311	Membrane
B657_RS21125	COG1917	Cupin 2, conserved barrel domain protein
B657_RS21130	COG1309	transcriptional regulator
B657_RS21135	COG1028	Short-chain dehydrogenase reductase Sdr
B657_RS21140	COG1846	Transcriptional regulator
B657_RS21145	COG1380	Effector of murein hydrolase LrgA
B657_RS21150	COG1346	cytolysis
B657_RS21155	COG5039	Polysaccharide pyruvyl transferase
B657_RS21160	COG1929	Belongs to the glycerate kinase type-1 family
B657_RS21165	COG1802	Transcriptional regulator
B657_RS21170	COG1070	Carbohydrate kinase
B657_RS21175	COG2610	gluconate transmembrane transporter activity
B657_RS21180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B657_RS21185	COG0450	alkyl hydroperoxide reductase
B657_RS21190	COG3634	alkyl hydroperoxide reductase activity
B657_RS21195	COG2723	6-phospho-beta-galactosidase activity
B657_RS21200	COG2190	(PTS) system
B657_RS21205	COG2188	Transcriptional regulator
B657_RS21220	COG1131	(ABC) transporter
B657_RS21225	COG1994	Peptidase M50
B657_RS21230	COG0535	radical SAM domain protein
B657_RS21240	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B657_RS21245	COG5293	efflux transmembrane transporter activity
B657_RS21255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_RS21260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B657_RS21270	COG1063	alcohol dehydrogenase
B657_RS21290	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B657_RS21295	COG0456	acetyltransferase
B657_RS21300	COG0457	Tetratricopeptide repeat
B657_RS21310	COG0010	Belongs to the arginase family
B657_RS21315	COG0833	amino acid
B657_RS21320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B657_RS21325	COG3829	transcription factor binding
B657_RS21330	COG5002	protein histidine kinase activity
B657_RS21340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_RS21345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B657_RS21350	COG4853	Protein conserved in bacteria
B657_RS21355	COG4863	YycH protein
B657_RS21360	COG5002	protein histidine kinase activity
B657_RS21365	COG0745	RESPONSE REGULATOR receiver
B657_RS21395	COG0346	lactoylglutathione lyase activity
B657_RS21400	COG0305	Participates in initiation and elongation during chromosome replication
B657_RS21420	COG3093	addiction module antidote protein HigA
B657_RS21425	COG2807	transmembrane transport
B657_RS21430	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B657_RS21435	COG0359	binds to the 23S rRNA
B657_RS21440	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B657_RS21445	COG4241	membrane
B657_RS21455	COG5577	PFAM Coat F domain
B657_RS21460	COG1733	regulation of RNA biosynthetic process
B657_RS21465	COG1227	inorganic diphosphatase activity
B657_RS21480	COG2271	Major facilitator Superfamily
B657_RS21490	COG4319	ketosteroid isomerase
B657_RS21520	COG1131	(ABC) transporter
B657_RS21530	COG4319	ketosteroid isomerase
B657_RS21535	COG1357	PFAM Pentapeptide repeats (8 copies)
B657_RS21540	COG2814	Major facilitator Superfamily
B657_RS21545	COG0583	DNA-binding transcription factor activity
B657_RS21550	COG2153	protein acetylation
B657_RS21560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_RS21565	COG1846	Transcriptional regulator
B657_RS21570	COG2153	protein acetylation
B657_RS21575	COG2364	Membrane
B657_RS21580	COG0456	acetyltransferase
B657_RS21585	COG2315	Protein conserved in bacteria
B657_RS21590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_RS21595	COG2814	Major facilitator Superfamily
B657_RS21600	COG1331	Highly conserved protein containing a thioredoxin domain
B657_RS21605	COG0789	Transcriptional regulator
B657_RS21610	COG0697	spore germination
B657_RS21615	COG1331	Highly conserved protein containing a thioredoxin domain
B657_RS21620	COG1266	CAAX protease self-immunity
B657_RS21625	COG2814	Major facilitator Superfamily
B657_RS21625	COG0477	Major facilitator Superfamily
B657_RS21630	COG0110	maltose O-acetyltransferase activity
B657_RS21635	COG0346	lactoylglutathione lyase activity
B657_RS21640	COG1609	Transcriptional regulator
B657_RS21645	COG0708	Exodeoxyribonuclease III
B657_RS21650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B657_RS21655	COG0629	single-stranded DNA binding
B657_RS21660	COG0360	Binds together with S18 to 16S ribosomal RNA
B657_RS21665	COG0012	GTP binding
B657_RS21670	COG0243	molybdopterin cofactor binding
B657_RS21675	COG4481	Protein conserved in bacteria
B657_RS21680	COG3949	Membrane
B657_RS21690	COG1475	DNA binding
B657_RS21695	COG1192	Involved in chromosome partitioning
B657_RS21705	COG1475	DNA binding
B657_RS21710	COG0357	Ribosomal RNA small subunit methyltransferase G
B657_RS21715	COG0445	tRNA wobble uridine modification
B657_RS21720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B657_RS21725	COG1847	R3H domain protein
B657_RS21730	COG0706	membrane insertase activity
B657_RS21735	COG0594	ribonuclease P activity
B657_RS21750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_RS21750	COG1372	Participates in initiation and elongation during chromosome replication