locus-tag	class	description
GO004_RS00005	COG4978	Transcriptional regulator
GO004_RS00005	COG0789	Transcriptional regulator
GO004_RS00015	COG3959	Transketolase, thiamine diphosphate binding domain
GO004_RS00020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO004_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS00040	COG2186	Transcriptional regulator
GO004_RS00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO004_RS00060	COG2070	2-Nitropropane dioxygenase
GO004_RS00070	COG2318	DinB family
GO004_RS00085	COG1335	isochorismatase
GO004_RS00095	COG2124	cytochrome p450
GO004_RS00105	COG1522	sequence-specific DNA binding
GO004_RS00110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO004_RS00115	COG1687	branched-chain amino acid
GO004_RS00120	COG1114	Component of the transport system for branched-chain amino acids
GO004_RS00130	COG0583	DNA-binding transcription factor activity
GO004_RS00135	COG1942	4-Oxalocrotonate Tautomerase
GO004_RS00140	COG1230	cation diffusion facilitator family transporter
GO004_RS00145	COG2072	flavoprotein involved in K transport
GO004_RS00150	COG0583	DNA-binding transcription factor activity
GO004_RS00155	COG0697	spore germination
GO004_RS00165	COG1253	flavin adenine dinucleotide binding
GO004_RS00170	COG0456	acetyltransferase
GO004_RS00175	COG2814	Major facilitator Superfamily
GO004_RS00180	COG0789	Transcriptional regulator
GO004_RS00180	COG4978	Transcriptional regulator
GO004_RS00190	COG0662	Cupin 2, conserved barrel domain protein
GO004_RS00195	COG1937	Protein conserved in bacteria
GO004_RS00200	COG2210	Belongs to the sulfur carrier protein TusA family
GO004_RS00205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_RS00205	COG0425	Belongs to the sulfur carrier protein TusA family
GO004_RS00215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_RS00215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS00220	COG0425	Belongs to the sulfur carrier protein TusA family
GO004_RS00225	COG0730	response to heat
GO004_RS00230	COG4124	Belongs to the glycosyl hydrolase 26 family
GO004_RS00250	COG2856	Zn peptidase
GO004_RS00255	COG0563	adenylate kinase activity
GO004_RS00265	COG3620	sequence-specific DNA binding
GO004_RS00270	COG1476	TRANSCRIPTIONal
GO004_RS00300	COG5377	YqaJ viral recombinase family
GO004_RS00305	COG3723	Recombinational DNA repair protein, rece pathway
GO004_RS00310	COG3935	DnaD domain protein
GO004_RS00315	COG1484	DNA-dependent DNA replication
GO004_RS00325	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GO004_RS00340	COG3677	Transposase
GO004_RS00350	COG5484	DNA packaging
GO004_RS00355	COG1783	phage Terminase large subunit
GO004_RS00360	COG5518	Phage portal protein
GO004_RS00365	COG2369	cell adhesion
GO004_RS00375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO004_RS00380	COG4653	Phage capsid family
GO004_RS00440	COG5280	Phage tail tape measure protein TP901
GO004_RS00440	COG3953	SLT domain
GO004_RS00445	COG1652	LysM domain
GO004_RS00450	COG4193	domain, Protein
GO004_RS00460	COG1794	racemase activity, acting on amino acids and derivatives
GO004_RS00465	COG3628	GPW Gp25 family protein
GO004_RS00470	COG3299	homolog of phage Mu protein gp47
GO004_RS00475	COG3778	Protein conserved in bacteria
GO004_RS00505	COG4824	toxin secretion phage lysis holin
GO004_RS00510	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS00510	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS00535	COG5444	nuclease activity
GO004_RS00550	COG0457	Tetratricopeptide repeat
GO004_RS00575	COG0604	alcohol dehydrogenase
GO004_RS00595	COG3403	YqcI/YcgG family
GO004_RS00600	COG0640	Transcriptional regulator
GO004_RS00605	COG0346	lactoylglutathione lyase activity
GO004_RS00610	COG0798	PFAM Bile acid sodium symporter
GO004_RS00615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_RS00620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO004_RS00630	COG3209	COG3209 Rhs family protein
GO004_RS00640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GO004_RS00645	COG0398	Pfam SNARE associated Golgi protein
GO004_RS00650	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS00650	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS00655	COG2755	lipolytic protein G-D-S-L family
GO004_RS00665	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GO004_RS00670	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO004_RS00675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO004_RS00680	COG1534	Rna-binding protein
GO004_RS00685	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO004_RS00690	COG1713	HD superfamily hydrolase involved in NAD metabolism
GO004_RS00695	COG0799	negative regulation of ribosome biogenesis
GO004_RS00700	COG2226	methyltransferase
GO004_RS00705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_RS00710	COG1596	polysaccharide export
GO004_RS00710	COG1555	photosystem II stabilization
GO004_RS00715	COG2131	deaminase
GO004_RS00720	COG0658	competence protein
GO004_RS00720	COG2333	competence protein COMEC
GO004_RS00735	COG1466	dna polymerase III delta subunit
GO004_RS00740	COG0268	Binds directly to 16S ribosomal RNA
GO004_RS00745	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO004_RS00750	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS00760	COG0481	GTPase activity
GO004_RS00765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO004_RS00770	COG1420	regulation of RNA biosynthetic process
GO004_RS00775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO004_RS00780	COG0443	Heat shock 70 kDa protein
GO004_RS00785	COG0484	heat shock protein binding
GO004_RS00790	COG2264	protein methyltransferase activity
GO004_RS00795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO004_RS00800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO004_RS00805	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO004_RS00815	COG1610	YqeY-like protein
GO004_RS00820	COG1030	water channel activity
GO004_RS00825	COG4864	UPF0365 protein
GO004_RS00840	COG0561	phosphatase activity
GO004_RS00845	COG1702	phosphate starvation-inducible protein PhoH
GO004_RS00850	COG1480	7TM receptor with intracellular HD hydrolase
GO004_RS00855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO004_RS00860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO004_RS00865	COG0295	cytidine deaminase activity
GO004_RS00870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO004_RS00880	COG1381	Involved in DNA repair and RecF pathway recombination
GO004_RS00885	COG0752	glycyl-tRNA synthetase alpha subunit
GO004_RS00890	COG0751	glycine-tRNA ligase activity
GO004_RS00895	COG0517	IMP dehydrogenase activity
GO004_RS00900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO004_RS00905	COG1671	Belongs to the UPF0178 family
GO004_RS00910	COG0358	DNA primase activity
GO004_RS00915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO004_RS00920	COG2010	Cytochrome c
GO004_RS00925	COG2384	SAM-dependent methyltransferase
GO004_RS00930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO004_RS00935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO004_RS00945	COG0513	Belongs to the DEAD box helicase family
GO004_RS00950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO004_RS00960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS00965	COG0735	belongs to the Fur family
GO004_RS00970	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GO004_RS00975	COG4709	membrane
GO004_RS00980	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO004_RS00985	COG1388	LysM domain
GO004_RS00990	COG5521	maltodextrose utilization protein MalA
GO004_RS00995	COG2839	Protein conserved in bacteria
GO004_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO004_RS01005	COG0477	Major facilitator Superfamily
GO004_RS01010	COG0768	penicillin binding
GO004_RS01015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO004_RS01020	COG0573	inorganic phosphate transmembrane transporter activity
GO004_RS01025	COG0581	inorganic phosphate transmembrane transporter activity
GO004_RS01030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_RS01035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_RS01040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO004_RS01055	COG0438	transferase activity, transferring glycosyl groups
GO004_RS01065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO004_RS01075	COG0705	Rhomboid family
GO004_RS01075	COG0457	Tetratricopeptide repeat
GO004_RS01080	COG4483	Protein conserved in bacteria
GO004_RS01085	COG1940	carbohydrate kinase activity
GO004_RS01090	COG1368	sulfuric ester hydrolase activity
GO004_RS01095	COG2866	Carboxypeptidase
GO004_RS01105	COG0011	TIGRFAM Protein of
GO004_RS01115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS01125	COG1393	Belongs to the ArsC family
GO004_RS01135	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS01140	COG1253	flavin adenine dinucleotide binding
GO004_RS01145	COG0598	Magnesium transport protein CorA
GO004_RS01150	COG0517	IMP dehydrogenase activity
GO004_RS01155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO004_RS01160	COG1459	type II secretion system
GO004_RS01165	COG4537	Required for transformation and DNA binding
GO004_RS01170	COG4970	Tfp pilus assembly protein FimT
GO004_RS01180	COG4940	Competence protein ComGF
GO004_RS01205	COG0681	Belongs to the peptidase S26 family
GO004_RS01215	COG1396	sequence-specific DNA binding
GO004_RS01230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO004_RS01235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO004_RS01240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO004_RS01245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO004_RS01250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_RS01255	COG0095	Lipoate-protein ligase
GO004_RS01260	COG1321	iron dependent repressor
GO004_RS01265	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO004_RS01275	COG3872	metal-dependent enzyme
GO004_RS01285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO004_RS01290	COG0006	proline dipeptidase activity
GO004_RS01295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO004_RS01305	COG3854	ATPases associated with a variety of cellular activities
GO004_RS01345	COG0511	ligase activity, forming carbon-carbon bonds
GO004_RS01350	COG0439	Biotin carboxylase
GO004_RS01355	COG1302	Protein conserved in bacteria
GO004_RS01360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO004_RS01365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO004_RS01370	COG1570	exodeoxyribonuclease VII activity
GO004_RS01375	COG1722	exodeoxyribonuclease VII activity
GO004_RS01380	COG0142	geranyltranstransferase activity
GO004_RS01385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO004_RS01390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GO004_RS01395	COG1438	arginine binding
GO004_RS01400	COG0497	DNA recombination
GO004_RS01405	COG0750	zinc metalloprotease
GO004_RS01410	COG0745	RESPONSE REGULATOR receiver
GO004_RS01415	COG1902	pentaerythritol trinitrate reductase activity
GO004_RS01430	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_RS01440	COG0183	Belongs to the thiolase family
GO004_RS01445	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO004_RS01450	COG1960	acyl-CoA dehydrogenase activity
GO004_RS01455	COG0372	Belongs to the citrate synthase family
GO004_RS01460	COG2079	MmgE PrpD family protein
GO004_RS01465	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO004_RS01475	COG3290	protein histidine kinase activity
GO004_RS01475	COG3829	transcription factor binding
GO004_RS01480	COG0280	phosphate acetyltransferase
GO004_RS01485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_RS01490	COG3426	butyrate kinase activity
GO004_RS01495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_RS01500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_RS01505	COG0022	dehydrogenase e1 component
GO004_RS01510	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_RS01515	COG4978	Transcriptional regulator
GO004_RS01515	COG0789	Transcriptional regulator
GO004_RS01520	COG2814	Major facilitator Superfamily
GO004_RS01525	COG1597	lipid kinase activity
GO004_RS01535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS01540	COG0765	amino acid transport
GO004_RS01545	COG1126	abc transporter atp-binding protein
GO004_RS01550	COG4129	membrane
GO004_RS01555	COG1376	ErfK ybiS ycfS ynhG family protein
GO004_RS01565	COG0346	lactoylglutathione lyase activity
GO004_RS01570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO004_RS01575	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO004_RS01580	COG3361	conserved protein (COG2071)
GO004_RS01585	COG0706	membrane insertase activity
GO004_RS01595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_RS01600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO004_RS01605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO004_RS01610	COG1234	tRNA 3'-trailer cleavage
GO004_RS01620	COG0596	Alpha beta hydrolase
GO004_RS01625	COG1902	pentaerythritol trinitrate reductase activity
GO004_RS01630	COG4187	Peptidase family M20/M25/M40
GO004_RS01635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_RS01640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS01645	COG0300	oxidoreductase activity
GO004_RS01650	COG3048	D-serine ammonia-lyase activity
GO004_RS01655	COG1072	(Pantothenic acid kinase))
GO004_RS01660	COG0346	lactoylglutathione lyase activity
GO004_RS01670	COG2211	Major facilitator Superfamily
GO004_RS01680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_RS01690	COG0456	acetyltransferase
GO004_RS01695	COG2329	Antibiotic biosynthesis monooxygenase
GO004_RS01700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GO004_RS01700	COG0456	acetyltransferase
GO004_RS01705	COG4918	Iron-sulphur cluster biosynthesis
GO004_RS01715	COG1073	alpha beta
GO004_RS01725	COG0667	Aldo Keto reductase
GO004_RS01735	COG0494	nUDIX hydrolase
GO004_RS01740	COG1379	DNA repair
GO004_RS01745	COG1396	sequence-specific DNA binding
GO004_RS01750	COG0252	asparaginase activity
GO004_RS01755	COG1027	Aspartate ammonia-lyase
GO004_RS01760	COG1757	Na H antiporter
GO004_RS01765	COG0281	malic enzyme
GO004_RS01775	COG1300	Membrane
GO004_RS01780	COG0735	belongs to the Fur family
GO004_RS01790	COG4974	Belongs to the 'phage' integrase family
GO004_RS01795	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO004_RS01800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO004_RS01805	COG1686	Belongs to the peptidase S11 family
GO004_RS01810	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS01815	COG2172	sigma factor antagonist activity
GO004_RS01820	COG1191	sigma factor activity
GO004_RS01840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_RS01855	COG0697	spore germination
GO004_RS01860	COG0019	diaminopimelate decarboxylase activity
GO004_RS01865	COG4086	secreted protein
GO004_RS01870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO004_RS01905	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GO004_RS01915	COG0681	Belongs to the peptidase S26 family
GO004_RS01925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO004_RS01925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO004_RS01930	COG0307	riboflavin synthase, alpha
GO004_RS01935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO004_RS01935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO004_RS01940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO004_RS01945	COG0456	acetyltransferase
GO004_RS01950	COG1547	Domain of unknown function (DUF309)
GO004_RS01955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GO004_RS01960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO004_RS01970	COG1686	Belongs to the peptidase S11 family
GO004_RS01975	COG2715	membrane protein required for spore maturation
GO004_RS01980	COG0700	Nucleoside recognition
GO004_RS01985	COG1187	pseudouridine synthase activity
GO004_RS01990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS01995	COG1333	cytochrome c biogenesis protein
GO004_RS02000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO004_RS02005	COG0745	RESPONSE REGULATOR receiver
GO004_RS02010	COG5002	protein histidine kinase activity
GO004_RS02015	COG1595	DNA-templated transcription, initiation
GO004_RS02025	COG0710	3-dehydroquinate dehydratase activity
GO004_RS02030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO004_RS02035	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GO004_RS02040	COG1141	Ferredoxin
GO004_RS02045	COG4955	Helix-turn-helix domain
GO004_RS02050	COG0514	ATP-dependent DNA helicase (RecQ)
GO004_RS02055	COG1266	CAAX protease self-immunity
GO004_RS02060	COG1388	LysM domain
GO004_RS02070	COG1408	metallophosphoesterase
GO004_RS02075	COG4862	establishment of competence for transformation
GO004_RS02080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_RS02085	COG0492	ferredoxin-NADP+ reductase activity
GO004_RS02090	COG2339	peptidase activity
GO004_RS02095	COG3773	Cell wall hydrolase
GO004_RS02095	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS02100	COG2959	enzyme of heme biosynthesis
GO004_RS02105	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GO004_RS02115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO004_RS02120	COG0539	negative regulation of cytoplasmic translation
GO004_RS02125	COG1304	FMN binding
GO004_RS02150	COG1160	GTP binding
GO004_RS02155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO004_RS02170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO004_RS02175	COG0776	regulation of translation
GO004_RS02180	COG0302	gtp cyclohydrolase
GO004_RS02190	COG0142	geranyltranstransferase activity
GO004_RS02195	COG2226	methyltransferase
GO004_RS02200	COG0142	geranyltranstransferase activity
GO004_RS02205	COG0105	UTP biosynthetic process
GO004_RS02210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO004_RS02215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO004_RS02220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO004_RS02225	COG4401	Chorismate mutase type I
GO004_RS02230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO004_RS02235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO004_RS02245	COG0135	phosphoribosylanthranilate isomerase activity
GO004_RS02250	COG0133	tryptophan synthase activity
GO004_RS02255	COG0159	tryptophan synthase activity
GO004_RS02260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO004_RS02265	COG0287	Prephenate dehydrogenase
GO004_RS02270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO004_RS02275	COG0457	Tetratricopeptide repeat
GO004_RS02280	COG5582	Belongs to the UPF0302 family
GO004_RS02290	COG0723	plastoquinol--plastocyanin reductase activity
GO004_RS02295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO004_RS02300	COG2010	Cytochrome c
GO004_RS02300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO004_RS02305	COG4347	Protein of unknown function (DUF1405)
GO004_RS02315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS02320	COG1694	Mazg nucleotide pyrophosphohydrolase
GO004_RS02325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO004_RS02330	COG1803	Methylglyoxal synthase
GO004_RS02335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_RS02340	COG0438	transferase activity, transferring glycosyl groups
GO004_RS02345	COG0617	tRNA 3'-terminal CCA addition
GO004_RS02350	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GO004_RS02350	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GO004_RS02355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO004_RS02360	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO004_RS02365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GO004_RS02370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO004_RS02370	COG1199	ATP-dependent helicase activity
GO004_RS02380	COG5353	protein conserved in bacteria
GO004_RS02385	COG0436	Aminotransferase
GO004_RS02390	COG0017	Asparaginyl-tRNA synthetase
GO004_RS02395	COG3935	DnaD domain protein
GO004_RS02400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO004_RS02410	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO004_RS02410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_RS02415	COG3331	DNA recombination
GO004_RS02450	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_RS02455	COG2190	(PTS) system
GO004_RS02460	COG1205	dead DEAH box helicase
GO004_RS02460	COG1111	helicase
GO004_RS02465	COG3359	exonuclease
GO004_RS02480	COG4474	Belongs to the UPF0398 family
GO004_RS02495	COG0116	Belongs to the methyltransferase superfamily
GO004_RS02510	COG1199	ATP-dependent helicase activity
GO004_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS02520	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GO004_RS02525	COG1609	Transcriptional regulator
GO004_RS02530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_RS02535	COG0800	Aldolase
GO004_RS02545	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO004_RS02550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_RS02555	COG2233	PERMEase
GO004_RS02560	COG3424	synthase
GO004_RS02565	COG1755	Isoprenylcysteine carboxyl methyltransferase
GO004_RS02575	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO004_RS02590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_RS02600	COG0328	RNA-DNA hybrid ribonuclease activity
GO004_RS02605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO004_RS02610	COG0328	RNA-DNA hybrid ribonuclease activity
GO004_RS02630	COG1278	Cold shock
GO004_RS02640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_RS02645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO004_RS02650	COG0386	Belongs to the glutathione peroxidase family
GO004_RS02655	COG1418	mRNA catabolic process
GO004_RS02660	COG1413	lyase activity
GO004_RS02665	COG0129	dihydroxy-acid dehydratase activity
GO004_RS02675	COG2521	methyltransferase
GO004_RS02675	COG2136	Putative SAM-dependent methyltransferase
GO004_RS02685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO004_RS02690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO004_RS02695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_RS02700	COG0204	Acyl-transferase
GO004_RS02705	COG1272	protein, Hemolysin III
GO004_RS02710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO004_RS02715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO004_RS02725	COG1999	signal sequence binding
GO004_RS02730	COG2755	lipolytic protein G-D-S-L family
GO004_RS02735	COG4698	Protein conserved in bacteria
GO004_RS02745	COG0534	Mate efflux family protein
GO004_RS02750	COG1846	Transcriptional regulator
GO004_RS02755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO004_RS02760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO004_RS02765	COG1086	Polysaccharide biosynthesis protein
GO004_RS02770	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GO004_RS02775	COG4641	Protein conserved in bacteria
GO004_RS02790	COG0463	Glycosyl transferase, family 2
GO004_RS02795	COG0456	acetyltransferase
GO004_RS02810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_RS02815	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO004_RS02820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO004_RS02825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_RS02830	COG0456	acetyltransferase
GO004_RS02835	COG1509	lysine 2,3-aminomutase activity
GO004_RS02845	COG4479	Belongs to the UPF0346 family
GO004_RS02865	COG0671	phosphoesterase, PA-phosphatase related
GO004_RS02880	COG0813	purine-nucleoside phosphorylase activity
GO004_RS02885	COG1876	peptidase activity
GO004_RS02895	COG2226	methyltransferase
GO004_RS02900	COG0793	Belongs to the peptidase S41A family
GO004_RS02900	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS02905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_RS02915	COG0346	lactoylglutathione lyase activity
GO004_RS02920	COG0400	carboxylic ester hydrolase activity
GO004_RS02925	COG0778	Nitroreductase
GO004_RS02930	COG1733	regulation of RNA biosynthetic process
GO004_RS02935	COG1942	4-Oxalocrotonate Tautomerase
GO004_RS02940	COG2610	gluconate transmembrane transporter activity
GO004_RS02955	COG2962	Rard protein
GO004_RS02965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_RS02970	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_RS02975	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS02980	COG0534	Mate efflux family protein
GO004_RS02985	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO004_RS02990	COG1819	glycosyl
GO004_RS02995	COG0791	NLP P60 protein
GO004_RS02995	COG1388	LysM domain
GO004_RS03000	COG2032	superoxide dismutase activity
GO004_RS03005	COG0714	Associated with various cellular activities
GO004_RS03010	COG4548	von Willebrand factor, type A
GO004_RS03015	COG0567	Dehydrogenase, E1 component
GO004_RS03020	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_RS03025	COG0385	Bile acid
GO004_RS03030	COG0733	neurotransmitter:sodium symporter activity
GO004_RS03035	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO004_RS03040	COG1657	PFAM Prenyltransferase squalene oxidase
GO004_RS03045	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS03070	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_RS03085	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_RS03090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO004_RS03100	COG0514	ATP-dependent DNA helicase (RecQ)
GO004_RS03105	COG3584	3D domain protein
GO004_RS03105	COG1388	LysM domain
GO004_RS03110	COG2197	response regulator
GO004_RS03115	COG4585	Histidine kinase
GO004_RS03120	COG3239	Fatty acid desaturase
GO004_RS03125	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO004_RS03140	COG2322	membrane
GO004_RS03145	COG0741	lytic transglycosylase activity
GO004_RS03150	COG0640	Transcriptional regulator
GO004_RS03160	COG2378	regulation of single-species biofilm formation
GO004_RS03165	COG3708	Transcriptional regulator
GO004_RS03170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS03175	COG1309	transcriptional regulator
GO004_RS03180	COG0456	acetyltransferase
GO004_RS03185	COG2207	Transcriptional regulator
GO004_RS03185	COG0662	Cupin 2, conserved barrel domain protein
GO004_RS03190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_RS03195	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_RS03200	COG1231	oxidoreductase activity
GO004_RS03205	COG4282	regulation of fungal-type cell wall biogenesis
GO004_RS03235	COG2314	TM2 domain
GO004_RS03240	COG0726	polysaccharide deacetylase
GO004_RS03245	COG0574	Belongs to the PEP-utilizing enzyme family
GO004_RS03245	COG3848	Pyruvate phosphate dikinase
GO004_RS03265	COG2367	Beta-lactamase
GO004_RS03270	COG0693	protein deglycase activity
GO004_RS03280	COG0697	spore germination
GO004_RS03285	COG0583	DNA-binding transcription factor activity
GO004_RS03290	COG3739	integral membrane protein
GO004_RS03295	COG3655	Transcriptional regulator
GO004_RS03305	COG2720	vancomycin resistance protein
GO004_RS03335	COG2140	Oxalate decarboxylase
GO004_RS03345	COG2135	peptidase activity
GO004_RS03350	COG3866	Pectate lyase
GO004_RS03355	COG3619	membrane
GO004_RS03360	COG4305	rare lipoprotein A
GO004_RS03365	COG2368	4-hydroxyphenylacetate
GO004_RS03370	COG5278	phosphoserine phosphatase activity
GO004_RS03370	COG0840	transmembrane signaling receptor activity
GO004_RS03400	COG0243	molybdopterin cofactor binding
GO004_RS03405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO004_RS03410	COG1070	Carbohydrate kinase
GO004_RS03415	COG2814	Major facilitator Superfamily
GO004_RS03430	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO004_RS03435	COG0300	oxidoreductase activity
GO004_RS03445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_RS03450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO004_RS03455	COG0583	DNA-binding transcription factor activity
GO004_RS03460	COG0067	glutamate synthase
GO004_RS03460	COG0069	glutamate synthase activity
GO004_RS03460	COG0070	glutamate synthase
GO004_RS03465	COG0493	'glutamate synthase
GO004_RS03470	COG0604	alcohol dehydrogenase
GO004_RS03475	COG0583	DNA-binding transcription factor activity
GO004_RS03480	COG0405	Gamma-glutamyltransferase
GO004_RS03485	COG0166	Belongs to the GPI family
GO004_RS03490	COG0582	viral genome integration into host DNA
GO004_RS03505	COG0534	Mate efflux family protein
GO004_RS03510	COG2017	converts alpha-aldose to the beta-anomer
GO004_RS03515	COG2027	D-alanyl-D-alanine carboxypeptidase
GO004_RS03520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS03525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS03530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS03535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS03540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS03540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO004_RS03550	COG1649	PFAM Uncharacterised BCR, COG1649
GO004_RS03565	COG1960	acyl-CoA dehydrogenase activity
GO004_RS03570	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS03575	COG0439	Biotin carboxylase
GO004_RS03580	COG0511	ligase activity, forming carbon-carbon bonds
GO004_RS03585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO004_RS03590	COG1024	Enoyl-CoA hydratase
GO004_RS03595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO004_RS03600	COG2404	hydrolase activity, acting on ester bonds
GO004_RS03605	COG0586	Pfam SNARE associated Golgi protein
GO004_RS03610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_RS03615	COG2246	polysaccharide biosynthetic process
GO004_RS03620	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_RS03625	COG5520	Belongs to the glycosyl hydrolase 30 family
GO004_RS03635	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GO004_RS03640	COG1115	amino acid carrier protein
GO004_RS03650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO004_RS03655	COG0187	DNA topoisomerase II activity
GO004_RS03660	COG1832	CoA-binding protein
GO004_RS03665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO004_RS03670	COG4841	protein insertion into membrane
GO004_RS03680	COG0824	Thioesterase
GO004_RS03700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS03705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO004_RS03720	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_RS03730	COG4846	Membrane protein involved in cytochrome C biogenesis
GO004_RS03735	COG2201	protein-glutamate methylesterase activity
GO004_RS03740	COG0785	Cytochrome C biogenesis protein
GO004_RS03750	COG3763	UPF0154 protein
GO004_RS03760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO004_RS03765	COG4224	UPF0291 protein
GO004_RS03770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO004_RS03775	COG1388	LysM domain
GO004_RS03780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO004_RS03785	COG0346	lactoylglutathione lyase activity
GO004_RS03795	COG4195	phage-related replication protein
GO004_RS03825	COG0531	amino acid
GO004_RS03840	COG3832	glyoxalase III activity
GO004_RS03850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_RS03890	COG0756	dUTP diphosphatase activity
GO004_RS03900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO004_RS03905	COG2814	Major facilitator Superfamily
GO004_RS03910	COG1525	nuclease
GO004_RS03920	COG1070	Carbohydrate kinase
GO004_RS03925	COG2115	Belongs to the xylose isomerase family
GO004_RS03930	COG1940	carbohydrate kinase activity
GO004_RS03935	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_RS03940	COG2211	Major facilitator Superfamily
GO004_RS03955	COG0135	phosphoribosylanthranilate isomerase activity
GO004_RS03970	COG3655	Transcriptional regulator
GO004_RS03985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS04005	COG0463	Glycosyl transferase, family 2
GO004_RS04040	COG0174	glutamine synthetase
GO004_RS04045	COG0789	Transcriptional regulator
GO004_RS04050	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GO004_RS04055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO004_RS04075	COG3331	DNA recombination
GO004_RS04125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO004_RS04155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_RS04185	COG0756	dUTP diphosphatase activity
GO004_RS04195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS04220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_RS04220	COG1372	Participates in initiation and elongation during chromosome replication
GO004_RS04225	COG1780	Probably involved in ribonucleotide reductase function
GO004_RS04325	COG0270	DNA (cytosine-5-)-methyltransferase activity
GO004_RS04340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO004_RS04365	COG3584	3D domain protein
GO004_RS04370	COG0587	DNA-directed DNA polymerase activity
GO004_RS04375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO004_RS04380	COG0358	DNA primase activity
GO004_RS04385	COG0305	Participates in initiation and elongation during chromosome replication
GO004_RS04395	COG2887	Belongs to the helicase family. UvrD subfamily
GO004_RS04445	COG2135	peptidase activity
GO004_RS04450	COG1793	dna ligase
GO004_RS04530	COG3655	Transcriptional regulator
GO004_RS04545	COG0582	viral genome integration into host DNA
GO004_RS04675	COG0582	viral genome integration into host DNA
GO004_RS04715	COG2433	Pfam Transposase IS66
GO004_RS04725	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_RS04730	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS04730	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS04745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO004_RS04750	COG0463	Glycosyl transferase, family 2
GO004_RS04755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS04760	COG3271	cysteine-type peptidase activity
GO004_RS04760	COG2274	protein secretion by the type I secretion system
GO004_RS04775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_RS04790	COG0457	Tetratricopeptide repeat
GO004_RS04810	COG5444	nuclease activity
GO004_RS04815	COG4282	regulation of fungal-type cell wall biogenesis
GO004_RS04825	COG1525	nuclease
GO004_RS04840	COG0464	growth
GO004_RS04845	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS04850	COG4112	unkown
GO004_RS04855	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_RS04860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_RS04865	COG1780	Probably involved in ribonucleotide reductase function
GO004_RS04880	COG1923	regulation of RNA biosynthetic process
GO004_RS04885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO004_RS04900	COG2076	Multidrug Resistance protein
GO004_RS04905	COG2076	Multidrug Resistance protein
GO004_RS04910	COG1764	response to oxidative stress
GO004_RS04915	COG4195	phage-related replication protein
GO004_RS04925	COG1404	Belongs to the peptidase S8 family
GO004_RS04930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS04940	COG2124	cytochrome p450
GO004_RS04945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_RS04945	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO004_RS04945	COG3321	synthase
GO004_RS04945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO004_RS04950	COG4221	oxidoreductase activity
GO004_RS04950	COG3321	synthase
GO004_RS04950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_RS04955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_RS04955	COG3321	synthase
GO004_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS04955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS04960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_RS04960	COG0300	oxidoreductase activity
GO004_RS04960	COG3321	synthase
GO004_RS04960	COG4221	oxidoreductase activity
GO004_RS04965	COG0300	oxidoreductase activity
GO004_RS04965	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS04965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS04965	COG3321	synthase
GO004_RS04970	COG1024	Enoyl-CoA hydratase
GO004_RS04975	COG1024	Enoyl-CoA hydratase
GO004_RS04980	COG3425	synthase
GO004_RS04985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO004_RS04990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_RS04995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_RS04995	COG2070	2-Nitropropane dioxygenase
GO004_RS05000	COG3321	synthase
GO004_RS05005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_RS05015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS05020	COG3226	Transcriptional regulator
GO004_RS05035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO004_RS05040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO004_RS05050	COG4550	Control of competence regulator ComK, YlbF/YmcA
GO004_RS05055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO004_RS05060	COG0156	8-amino-7-oxononanoate synthase activity
GO004_RS05065	COG1063	alcohol dehydrogenase
GO004_RS05070	COG2359	stage V sporulation protein S
GO004_RS05075	COG1692	metallophosphoesterase
GO004_RS05080	COG1418	mRNA catabolic process
GO004_RS05085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_RS05090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO004_RS05095	COG1546	Belongs to the CinA family
GO004_RS05095	COG1058	Belongs to the CinA family
GO004_RS05100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO004_RS05105	COG1426	Protein conserved in bacteria
GO004_RS05120	COG0300	oxidoreductase activity
GO004_RS05125	COG0612	Peptidase, M16
GO004_RS05130	COG0612	Peptidase, M16
GO004_RS05135	COG2814	Major facilitator Superfamily
GO004_RS05140	COG2188	Transcriptional regulator
GO004_RS05145	COG4980	gas vesicle protein
GO004_RS05145	COG1674	ftsk spoiiie
GO004_RS05155	COG0740	serine-type endopeptidase activity
GO004_RS05160	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO004_RS05165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO004_RS05170	COG0527	aspartate kinase activity
GO004_RS05175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO004_RS05180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO004_RS05185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO004_RS05190	COG1873	PFAM PRC-barrel domain
GO004_RS05195	COG0612	Peptidase, M16
GO004_RS05200	COG0726	polysaccharide deacetylase
GO004_RS05205	COG1185	polyribonucleotide nucleotidyltransferase activity
GO004_RS05210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO004_RS05215	COG0196	riboflavin kinase activity
GO004_RS05220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO004_RS05225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO004_RS05230	COG1550	Protein conserved in bacteria
GO004_RS05235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO004_RS05240	COG1358	cellular component organization or biogenesis
GO004_RS05245	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GO004_RS05250	COG0195	Participates in both transcription termination and antitermination
GO004_RS05255	COG0779	Required for maturation of 30S ribosomal subunits
GO004_RS05260	COG2176	DNA-directed DNA polymerase activity
GO004_RS05265	COG0442	prolyl-tRNA aminoacylation
GO004_RS05270	COG0750	zinc metalloprotease
GO004_RS05275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO004_RS05280	COG4589	Belongs to the CDS family
GO004_RS05285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO004_RS05290	COG0233	cytoplasmic translational termination
GO004_RS05295	COG0528	UMP kinase activity
GO004_RS05300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO004_RS05305	COG0052	Belongs to the universal ribosomal protein uS2 family
GO004_RS05315	COG1191	sigma factor activity
GO004_RS05320	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO004_RS05325	COG1776	CheC inhibitor of MCP methylation
GO004_RS05330	COG0835	chemotaxis
GO004_RS05335	COG0643	Histidine kinase
GO004_RS05335	COG2198	Histidine kinase
GO004_RS05340	COG2201	protein-glutamate methylesterase activity
GO004_RS05345	COG0455	bacterial-type flagellum organization
GO004_RS05350	COG1419	protein localization to endoplasmic reticulum
GO004_RS05355	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO004_RS05360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO004_RS05365	COG1684	flagellar biosynthetic protein fliR
GO004_RS05370	COG1987	bacterial-type flagellum assembly
GO004_RS05375	COG1338	Plays a role in the flagellum-specific transport system
GO004_RS05380	COG3190	flagellar
GO004_RS05390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_RS05390	COG1776	CheC inhibitor of MCP methylation
GO004_RS05395	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_RS05400	COG1580	Controls the rotational direction of flagella during chemotaxis
GO004_RS05405	COG1582	Flagellar protein (FlbD)
GO004_RS05410	COG4786	Flagellar basal body rod
GO004_RS05415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO004_RS05420	COG3144	bacterial-type flagellum assembly
GO004_RS05425	COG3334	PFAM MgtE intracellular
GO004_RS05430	COG2882	bacterial-type flagellum organization
GO004_RS05435	COG1157	protein secretion by the type III secretion system
GO004_RS05440	COG1317	bacterial-type flagellum organization
GO004_RS05445	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_RS05450	COG1766	The M ring may be actively involved in energy transduction
GO004_RS05455	COG1677	Flagellar hook-basal body complex protein FliE
GO004_RS05460	COG1558	bacterial-type flagellum-dependent cell motility
GO004_RS05465	COG1815	bacterial-type flagellum-dependent cell motility
GO004_RS05470	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO004_RS05475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO004_RS05480	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO004_RS05485	COG4974	Belongs to the 'phage' integrase family
GO004_RS05490	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GO004_RS05495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO004_RS05500	COG0758	DNA mediated transformation
GO004_RS05505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO004_RS05510	COG0045	succinate-CoA ligase (ADP-forming) activity
GO004_RS05515	COG2257	FlhB HrpN YscU SpaS Family
GO004_RS05525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO004_RS05530	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO004_RS05535	COG0335	large ribosomal subunit rRNA binding
GO004_RS05540	COG0336	Belongs to the RNA methyltransferase TrmD family
GO004_RS05545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO004_RS05555	COG1837	Belongs to the UPF0109 family
GO004_RS05560	COG0228	four-way junction DNA binding
GO004_RS05565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO004_RS05570	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GO004_RS05580	COG0552	protein localization to endoplasmic reticulum
GO004_RS05585	COG1196	nuclear chromosome segregation
GO004_RS05590	COG0571	ribonuclease III activity
GO004_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS05605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_RS05610	COG0416	fatty acid biosynthetic process
GO004_RS05615	COG2050	protein possibly involved in aromatic compounds catabolism
GO004_RS05615	COG1349	DNA-binding transcription factor activity
GO004_RS05620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO004_RS05625	COG1760	l-serine dehydratase
GO004_RS05630	COG1760	l-serine dehydratase
GO004_RS05635	COG1461	Dihydroxyacetone kinase
GO004_RS05640	COG1302	Protein conserved in bacteria
GO004_RS05645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO004_RS05655	COG1564	THIamine pyrophosphokinase
GO004_RS05660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO004_RS05665	COG1162	GTPase activity
GO004_RS05670	COG2815	serine threonine protein kinase
GO004_RS05670	COG0515	serine threonine protein kinase
GO004_RS05675	COG0631	protein serine/threonine phosphatase activity
GO004_RS05680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO004_RS05685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO004_RS05685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO004_RS05690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO004_RS05695	COG0242	peptide deformylase activity
GO004_RS05700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO004_RS05705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO004_RS05710	COG1758	RNA polymerase activity
GO004_RS05715	COG0194	GDP metabolic process
GO004_RS05725	COG1561	YicC-like family, N-terminal region
GO004_RS05730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO004_RS05735	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GO004_RS05740	COG1648	precorrin-2 dehydrogenase activity
GO004_RS05745	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GO004_RS05750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO004_RS05755	COG0529	Catalyzes the synthesis of activated sulfate
GO004_RS05760	COG2046	Belongs to the sulfate adenylyltransferase family
GO004_RS05765	COG0306	phosphate transporter
GO004_RS05770	COG0175	sulfate reduction
GO004_RS05775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO004_RS05780	COG0284	orotidine-5'-phosphate decarboxylase activity
GO004_RS05785	COG0167	dihydroorotate dehydrogenase activity
GO004_RS05790	COG0543	2 iron, 2 sulfur cluster binding
GO004_RS05795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO004_RS05800	COG0505	Belongs to the CarA family
GO004_RS05805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO004_RS05810	COG0540	Belongs to the ATCase OTCase family
GO004_RS05815	COG2233	PERMEase
GO004_RS05820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GO004_RS05825	COG0564	pseudouridine synthase activity
GO004_RS05830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO004_RS05835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_RS05840	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO004_RS05845	COG3599	regulation of cell shape
GO004_RS05850	COG2302	S4 RNA-binding domain
GO004_RS05855	COG0762	integral membrane protein
GO004_RS05860	COG1799	cell septum assembly
GO004_RS05865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO004_RS05870	COG1496	oxidoreductase activity
GO004_RS05875	COG1873	PFAM PRC-barrel domain
GO004_RS05880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_RS05885	COG1119	ATPase activity
GO004_RS05890	COG1191	sigma factor activity
GO004_RS05895	COG1191	sigma factor activity
GO004_RS05905	COG1404	Belongs to the peptidase S8 family
GO004_RS05905	COG4412	M6 family metalloprotease domain protein
GO004_RS05910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO004_RS05915	COG0849	cell division
GO004_RS05920	COG3856	small basic protein
GO004_RS05925	COG3879	Bacterial protein of unknown function (DUF881)
GO004_RS05930	COG3879	Bacterial protein of unknown function (DUF881)
GO004_RS05935	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO004_RS05940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO004_RS05945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_RS05950	COG0772	Belongs to the SEDS family
GO004_RS05955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO004_RS05960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO004_RS05965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO004_RS05970	COG0768	penicillin binding
GO004_RS05975	COG0768	penicillin binding
GO004_RS05980	COG4839	cell division protein FtsL
GO004_RS05985	COG0275	rRNA processing
GO004_RS05990	COG2001	Belongs to the MraZ family
GO004_RS05995	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GO004_RS06000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO004_RS06005	COG0454	-acetyltransferase
GO004_RS06020	COG1399	metal-binding, possibly nucleic acid-binding protein
GO004_RS06030	COG1323	Belongs to the UPF0348 family
GO004_RS06035	COG3480	Lon protease (S16) C-terminal proteolytic domain
GO004_RS06040	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO004_RS06045	COG3314	Sporulation integral membrane protein YlbJ
GO004_RS06050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO004_RS06055	COG0742	ribosomal rna small subunit methyltransferase
GO004_RS06060	COG4471	UPF0298 protein
GO004_RS06065	COG3679	Belongs to the UPF0342 family
GO004_RS06080	COG2340	Cysteine-rich secretory protein family
GO004_RS06085	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GO004_RS06095	COG3336	cytochrome c oxidase
GO004_RS06100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO004_RS06105	COG1845	cytochrome c oxidase, subunit III
GO004_RS06110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO004_RS06115	COG2010	Cytochrome c
GO004_RS06115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO004_RS06120	COG0109	protoheme IX farnesyltransferase activity
GO004_RS06125	COG1612	heme a metabolic process
GO004_RS06130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GO004_RS06135	COG0772	Belongs to the SEDS family
GO004_RS06140	COG4838	Belongs to the UPF0358 family
GO004_RS06145	COG2066	Belongs to the glutaminase family
GO004_RS06150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO004_RS06155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO004_RS06165	COG4896	Protein conserved in bacteria
GO004_RS06175	COG1217	gtp-binding protein TYPA
GO004_RS06195	COG1595	DNA-templated transcription, initiation
GO004_RS06215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GO004_RS06225	COG0483	inositol monophosphate 1-phosphatase activity
GO004_RS06235	COG4493	Belongs to the UPF0637 family
GO004_RS06240	COG4476	Belongs to the UPF0223 family
GO004_RS06245	COG1982	Orn Lys Arg decarboxylase major
GO004_RS06255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS06260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_RS06265	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_RS06270	COG0022	dehydrogenase e1 component
GO004_RS06275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_RS06280	COG0497	DNA recombination
GO004_RS06290	COG0242	peptide deformylase activity
GO004_RS06295	COG0561	phosphatase activity
GO004_RS06300	COG5503	Protein of unknown function (DUF1447)
GO004_RS06305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO004_RS06310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO004_RS06315	COG0569	domain protein
GO004_RS06320	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GO004_RS06320	COG2105	PFAM AIG2 family protein
GO004_RS06325	COG3852	Histidine kinase
GO004_RS06330	COG2002	toxin-antitoxin pair type II binding
GO004_RS06335	COG1077	Cell shape determining protein MreB Mrl
GO004_RS06345	COG2309	aminopeptidase activity
GO004_RS06350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO004_RS06355	COG0488	(ABC) transporter
GO004_RS06365	COG0681	Belongs to the peptidase S26 family
GO004_RS06370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_RS06370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_RS06370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS06375	COG1105	Belongs to the carbohydrate kinase PfkB family
GO004_RS06380	COG1349	DNA-binding transcription factor activity
GO004_RS06385	COG0577	efflux transmembrane transporter activity
GO004_RS06390	COG1136	(ABC) transporter
GO004_RS06395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO004_RS06405	COG1132	(ABC) transporter
GO004_RS06410	COG1132	(ABC) transporter
GO004_RS06415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO004_RS06420	COG0314	molybdopterin synthase activity
GO004_RS06425	COG1763	Mo-molybdopterin cofactor biosynthetic process
GO004_RS06430	COG0303	'Molybdopterin
GO004_RS06435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO004_RS06440	COG0746	molybdenum cofactor guanylyltransferase activity
GO004_RS06455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS06460	COG0450	alkyl hydroperoxide reductase
GO004_RS06465	COG0668	transmembrane transport
GO004_RS06475	COG1473	amidohydrolase
GO004_RS06480	COG2171	N-acyltransferase activity
GO004_RS06485	COG0716	FMN binding
GO004_RS06495	COG0716	FMN binding
GO004_RS06500	COG0583	DNA-binding transcription factor activity
GO004_RS06505	COG0517	IMP dehydrogenase activity
GO004_RS06515	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GO004_RS06520	COG4703	Protein of unknown function (DUF1797)
GO004_RS06525	COG2200	EAL domain
GO004_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS06535	COG1408	metallophosphoesterase
GO004_RS06540	COG1376	ErfK ybiS ycfS ynhG family protein
GO004_RS06545	COG2814	Major facilitator Superfamily
GO004_RS06555	COG0784	Response regulator, receiver
GO004_RS06555	COG0835	chemotaxis
GO004_RS06565	COG0436	Aminotransferase
GO004_RS06570	COG4191	Histidine kinase
GO004_RS06575	COG0768	penicillin binding
GO004_RS06580	COG2340	Cysteine-rich secretory protein family
GO004_RS06585	COG2084	Dehydrogenase
GO004_RS06590	COG0840	transmembrane signaling receptor activity
GO004_RS06595	COG0456	acetyltransferase
GO004_RS06600	COG1533	DNA photolyase activity
GO004_RS06610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO004_RS06615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS06620	COG2190	(PTS) system
GO004_RS06620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS06620	COG1263	PTS System
GO004_RS06625	COG3711	transcriptional antiterminator
GO004_RS06630	COG1609	Transcriptional regulator
GO004_RS06635	COG0006	proline dipeptidase activity
GO004_RS06645	COG2217	Heavy metal translocating P-type atpase
GO004_RS06650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS06655	COG2244	polysaccharide biosynthetic process
GO004_RS06660	COG3773	Cell wall hydrolase
GO004_RS06670	COG4873	Protein conserved in bacteria
GO004_RS06680	COG3858	chitin binding
GO004_RS06685	COG1388	LysM domain
GO004_RS06690	COG1388	LysM domain
GO004_RS06690	COG4641	Protein conserved in bacteria
GO004_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS06700	COG1733	regulation of RNA biosynthetic process
GO004_RS06705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO004_RS06710	COG0602	queuosine metabolic process
GO004_RS06715	COG0720	synthase
GO004_RS06720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO004_RS06725	COG3949	Membrane
GO004_RS06730	COG0542	response to heat
GO004_RS06735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO004_RS06740	COG1360	Flagellar Motor Protein
GO004_RS06745	COG1846	Transcriptional regulator
GO004_RS06750	COG3852	Histidine kinase
GO004_RS06765	COG3339	Conserved Protein
GO004_RS06770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GO004_RS06775	COG0235	Class ii aldolase
GO004_RS06780	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GO004_RS06785	COG1850	ribulose-bisphosphate carboxylase activity
GO004_RS06790	COG0436	Aminotransferase
GO004_RS06795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO004_RS06800	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GO004_RS06805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GO004_RS06815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO004_RS06820	COG5002	protein histidine kinase activity
GO004_RS06825	COG3594	Acyltransferase
GO004_RS06840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO004_RS06845	COG0501	Belongs to the peptidase M48B family
GO004_RS06865	COG1191	sigma factor activity
GO004_RS06870	COG0861	Integral membrane protein TerC family
GO004_RS06875	COG0586	Pfam SNARE associated Golgi protein
GO004_RS06880	COG5001	Diguanylate cyclase
GO004_RS06880	COG3300	MHYT domain
GO004_RS06885	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GO004_RS06890	COG3285	dna ligase
GO004_RS06890	COG1793	dna ligase
GO004_RS06895	COG0463	Glycosyl transferase, family 2
GO004_RS06905	COG1408	metallophosphoesterase
GO004_RS06910	COG0726	polysaccharide deacetylase
GO004_RS06915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_RS06920	COG1846	Transcriptional regulator
GO004_RS06935	COG0789	Transcriptional regulator
GO004_RS06940	COG2239	Acts as a magnesium transporter
GO004_RS06950	COG3212	peptidase
GO004_RS06955	COG3212	peptidase
GO004_RS06960	COG5002	protein histidine kinase activity
GO004_RS06960	COG3850	Histidine kinase
GO004_RS06965	COG0745	RESPONSE REGULATOR receiver
GO004_RS06975	COG4721	ABC-type cobalt transport system, permease component
GO004_RS06980	COG1122	ATPase activity
GO004_RS06985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO004_RS06990	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS06995	COG1404	Belongs to the peptidase S8 family
GO004_RS07000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_RS07005	COG0590	tRNA wobble adenosine to inosine editing
GO004_RS07015	COG1764	response to oxidative stress
GO004_RS07020	COG1846	Transcriptional regulator
GO004_RS07025	COG1764	response to oxidative stress
GO004_RS07030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO004_RS07035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO004_RS07040	COG0788	formyltetrahydrofolate deformylase activity
GO004_RS07045	COG2076	Multidrug Resistance protein
GO004_RS07050	COG2076	Multidrug Resistance protein
GO004_RS07055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS07060	COG2318	DinB family
GO004_RS07065	COG2323	membrane
GO004_RS07075	COG1017	nitric oxide dioxygenase activity
GO004_RS07075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO004_RS07080	COG1607	acyl-coa hydrolase
GO004_RS07085	COG1834	amidinotransferase
GO004_RS07090	COG2706	6-phosphogluconolactonase activity
GO004_RS07095	COG4608	Belongs to the ABC transporter superfamily
GO004_RS07100	COG0791	NLP P60 protein
GO004_RS07105	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_RS07110	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO004_RS07115	COG4166	transmembrane transport
GO004_RS07120	COG0444	Belongs to the ABC transporter superfamily
GO004_RS07125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_RS07130	COG0601	transmembrane transport
GO004_RS07135	COG2362	D-Aminopeptidase
GO004_RS07140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_RS07145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_RS07155	COG0463	Glycosyl transferase, family 2
GO004_RS07160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO004_RS07165	COG0346	lactoylglutathione lyase activity
GO004_RS07170	COG0531	amino acid
GO004_RS07175	COG1392	Phosphate transport regulator
GO004_RS07180	COG0306	phosphate transporter
GO004_RS07200	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS07200	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS07240	COG3778	Protein conserved in bacteria
GO004_RS07245	COG3299	homolog of phage Mu protein gp47
GO004_RS07250	COG3628	GPW Gp25 family protein
GO004_RS07260	COG4193	domain, Protein
GO004_RS07265	COG1652	LysM domain
GO004_RS07270	COG5412	phage tail tape measure protein
GO004_RS07270	COG3953	SLT domain
GO004_RS07320	COG4653	Phage capsid family
GO004_RS07325	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO004_RS07330	COG5518	Phage portal protein
GO004_RS07335	COG1783	phage Terminase large subunit
GO004_RS07340	COG5484	DNA packaging
GO004_RS07340	COG3728	DNA packaging
GO004_RS07345	COG1595	DNA-templated transcription, initiation
GO004_RS07365	COG1484	DNA-dependent DNA replication
GO004_RS07370	COG1522	sequence-specific DNA binding
GO004_RS07380	COG1396	sequence-specific DNA binding
GO004_RS07385	COG2856	Zn peptidase
GO004_RS07390	COG3546	catalase activity
GO004_RS07395	COG4195	phage-related replication protein
GO004_RS07405	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS07405	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS07405	COG1388	LysM domain
GO004_RS07410	COG2350	Protein conserved in bacteria
GO004_RS07420	COG0457	Tetratricopeptide repeat
GO004_RS07425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO004_RS07430	COG2318	DinB family
GO004_RS07435	COG0730	response to heat
GO004_RS07440	COG2721	sulfolactate sulfo-lyase activity
GO004_RS07445	COG0246	Mannitol dehydrogenase
GO004_RS07450	COG1609	Transcriptional regulator
GO004_RS07455	COG2271	Major facilitator Superfamily
GO004_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS07465	COG1312	Catalyzes the dehydration of D-mannonate
GO004_RS07470	COG1063	alcohol dehydrogenase
GO004_RS07475	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GO004_RS07480	COG2211	Major facilitator Superfamily
GO004_RS07485	COG1904	glucuronate isomerase
GO004_RS07490	COG1252	NADH dehydrogenase
GO004_RS07500	COG4297	protein containing double-stranded beta helix domain
GO004_RS07505	COG0697	spore germination
GO004_RS07510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_RS07515	COG0390	transport system, permease component
GO004_RS07520	COG1587	Uroporphyrinogen-III synthase
GO004_RS07530	COG1819	glycosyl
GO004_RS07535	COG2124	cytochrome p450
GO004_RS07545	COG1051	belongs to the nudix hydrolase family
GO004_RS07555	COG2427	Protein of unknown function (DUF1641)
GO004_RS07560	COG3383	formate dehydrogenase (NAD+) activity
GO004_RS07570	COG2205	protein histidine kinase activity
GO004_RS07575	COG5504	Zn-dependent protease
GO004_RS07590	COG0726	polysaccharide deacetylase
GO004_RS07600	COG0109	protoheme IX farnesyltransferase activity
GO004_RS07615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO004_RS07625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS07635	COG1482	cell wall glycoprotein biosynthetic process
GO004_RS07640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS07640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_RS07640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_RS07645	COG3711	transcriptional antiterminator
GO004_RS07645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS07660	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO004_RS07700	COG5444	nuclease activity
GO004_RS07715	COG5505	Protein of unknown function (DUF819)
GO004_RS07720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS07725	COG0626	cystathionine gamma-synthase activity
GO004_RS07730	COG0626	cystathionine gamma-synthase activity
GO004_RS07735	COG2382	esterase
GO004_RS07740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO004_RS07745	COG2153	protein acetylation
GO004_RS07755	COG0210	DNA helicase
GO004_RS07810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO004_RS07815	COG0351	phosphomethylpyrimidine kinase
GO004_RS07820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO004_RS07825	COG2022	thiamine diphosphate biosynthetic process
GO004_RS07830	COG2104	thiamine diphosphate biosynthetic process
GO004_RS07835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_RS07840	COG0352	thiamine-phosphate diphosphorylase activity
GO004_RS07845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO004_RS07850	COG0569	domain protein
GO004_RS07850	COG0475	glutathione-regulated potassium exporter activity
GO004_RS07855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO004_RS07860	COG0564	pseudouridine synthase activity
GO004_RS07865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO004_RS07870	COG2357	RelA SpoT domain protein
GO004_RS07880	COG4116	CYTH
GO004_RS07885	COG0741	lytic transglycosylase activity
GO004_RS07890	COG2346	COG2346, Truncated hemoglobins
GO004_RS07895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO004_RS07905	COG1164	Oligoendopeptidase f
GO004_RS07910	COG4469	Competence protein
GO004_RS07920	COG4862	establishment of competence for transformation
GO004_RS07930	COG0861	Integral membrane protein TerC family
GO004_RS07935	COG1393	Belongs to the ArsC family
GO004_RS07940	COG0456	acetyltransferase
GO004_RS07945	COG2814	Major facilitator Superfamily
GO004_RS07950	COG4608	Belongs to the ABC transporter superfamily
GO004_RS07955	COG0444	Belongs to the ABC transporter superfamily
GO004_RS07960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_RS07965	COG0601	transmembrane transport
GO004_RS07970	COG4166	transmembrane transport
GO004_RS07975	COG0180	Tryptophanyl-tRNA synthetase
GO004_RS07985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_RS07990	COG0601	transmembrane transport
GO004_RS08000	COG4608	Belongs to the ABC transporter superfamily
GO004_RS08005	COG0444	Belongs to the ABC transporter superfamily
GO004_RS08010	COG5504	Zn-dependent protease
GO004_RS08015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO004_RS08020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_RS08035	COG1744	ABC transporter substrate-binding protein PnrA-like
GO004_RS08045	COG2267	carboxylic ester hydrolase activity
GO004_RS08060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO004_RS08065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO004_RS08070	COG0505	Belongs to the CarA family
GO004_RS08075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO004_RS08085	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GO004_RS08090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO004_RS08095	COG2271	Major facilitator Superfamily
GO004_RS08100	COG0277	FAD linked oxidase domain protein
GO004_RS08110	COG2151	metal-sulfur cluster biosynthetic enzyme
GO004_RS08115	COG1073	alpha beta
GO004_RS08120	COG0561	phosphatase activity
GO004_RS08140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS08145	COG1307	EDD domain protein, DegV family
GO004_RS08150	COG3227	Zinc metalloprotease (Elastase)
GO004_RS08165	COG1695	Transcriptional regulator
GO004_RS08185	COG2996	Protein conserved in bacteria
GO004_RS08190	COG1666	GTP binding
GO004_RS08195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO004_RS08195	COG0646	methionine synthase
GO004_RS08200	COG2153	protein acetylation
GO004_RS08205	COG0454	-acetyltransferase
GO004_RS08210	COG2814	Major facilitator Superfamily
GO004_RS08215	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_RS08220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS08225	COG1809	phosphosulfolactate synthase activity
GO004_RS08230	COG2045	Belongs to the ComB family
GO004_RS08235	COG0175	sulfate reduction
GO004_RS08240	COG2046	Belongs to the sulfate adenylyltransferase family
GO004_RS08245	COG0529	Catalyzes the synthesis of activated sulfate
GO004_RS08250	COG2267	carboxylic ester hydrolase activity
GO004_RS08255	COG1357	PFAM Pentapeptide repeats (8 copies)
GO004_RS08260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS08265	COG1279	arginine transmembrane transporter activity
GO004_RS08270	COG2318	DinB family
GO004_RS08275	COG0673	inositol 2-dehydrogenase activity
GO004_RS08280	COG1609	Transcriptional regulator
GO004_RS08285	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS08285	COG2207	Transcriptional regulator
GO004_RS08290	COG0534	Mate efflux family protein
GO004_RS08295	COG1562	ergosterol biosynthetic process
GO004_RS08300	COG2318	DinB family
GO004_RS08305	COG0367	asparagine synthase
GO004_RS08315	COG1404	Belongs to the peptidase S8 family
GO004_RS08325	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO004_RS08330	COG5337	Spore coat protein CotH
GO004_RS08370	COG1403	HNH endonuclease
GO004_RS08375	COG0419	ATPase involved in DNA repair
GO004_RS08380	COG0420	3'-5' exonuclease activity
GO004_RS08385	COG1074	ATP-dependent DNA helicase activity
GO004_RS08390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GO004_RS08395	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GO004_RS08405	COG4533	DNA binding
GO004_RS08410	COG2814	Major facilitator Superfamily
GO004_RS08410	COG0477	Major facilitator Superfamily
GO004_RS08415	COG3180	Ammonia monooxygenase
GO004_RS08420	COG1609	Transcriptional regulator
GO004_RS08425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_RS08430	COG0561	phosphatase activity
GO004_RS08435	COG0673	inositol 2-dehydrogenase activity
GO004_RS08440	COG0738	Major facilitator superfamily
GO004_RS08445	COG1846	Transcriptional regulator
GO004_RS08450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO004_RS08455	COG0681	Belongs to the peptidase S26 family
GO004_RS08460	COG0398	Pfam SNARE associated Golgi protein
GO004_RS08475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_RS08485	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS08490	COG4903	ComK protein
GO004_RS08500	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS08505	COG0723	plastoquinol--plastocyanin reductase activity
GO004_RS08505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_RS08510	COG0840	transmembrane signaling receptor activity
GO004_RS08515	COG1268	BioY protein
GO004_RS08520	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS08525	COG0183	Belongs to the thiolase family
GO004_RS08530	COG0406	alpha-ribazole phosphatase activity
GO004_RS08535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO004_RS08540	COG0604	alcohol dehydrogenase
GO004_RS08545	COG0456	acetyltransferase
GO004_RS08555	COG0501	Belongs to the peptidase M48B family
GO004_RS08565	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS08570	COG0702	epimerase
GO004_RS08575	COG0095	Lipoate-protein ligase
GO004_RS08580	COG1234	tRNA 3'-trailer cleavage
GO004_RS08590	COG1301	dicarboxylic acid transport
GO004_RS08595	COG4405	Protein conserved in bacteria
GO004_RS08600	COG1363	Peptidase, m42
GO004_RS08610	COG4377	Putative membrane peptidase family (DUF2324)
GO004_RS08615	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_RS08620	COG1511	domain protein
GO004_RS08625	COG1309	transcriptional regulator
GO004_RS08630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GO004_RS08635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO004_RS08640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO004_RS08645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_RS08650	COG2329	Antibiotic biosynthesis monooxygenase
GO004_RS08660	COG3069	C4-dicarboxylate transmembrane transporter activity
GO004_RS08665	COG1473	amidohydrolase
GO004_RS08675	COG4473	ABC transporter
GO004_RS08680	COG1131	(ABC) transporter
GO004_RS08685	COG0537	adenosine 5'-monophosphoramidase activity
GO004_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO004_RS08705	COG4980	gas vesicle protein
GO004_RS08710	COG1846	Transcriptional regulator
GO004_RS08740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO004_RS08750	COG3481	metal-dependent phosphohydrolase, HD sub domain
GO004_RS08755	COG4717	serine-type aminopeptidase activity
GO004_RS08760	COG0420	3'-5' exonuclease activity
GO004_RS08770	COG4152	abc transporter atp-binding protein
GO004_RS08780	COG1024	Enoyl-CoA hydratase
GO004_RS08790	COG0490	domain, Protein
GO004_RS08795	COG0475	glutathione-regulated potassium exporter activity
GO004_RS08800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO004_RS08805	COG0561	phosphatase activity
GO004_RS08810	COG4335	DNA alkylation repair
GO004_RS08815	COG3679	Belongs to the UPF0342 family
GO004_RS08820	COG4399	Belongs to the UPF0754 family
GO004_RS08825	COG0189	ligase activity
GO004_RS08830	COG0189	ligase activity
GO004_RS08850	COG0702	epimerase
GO004_RS08855	COG1132	(ABC) transporter
GO004_RS08860	COG1132	(ABC) transporter
GO004_RS08870	COG0589	response to stress
GO004_RS08875	COG1757	Na H antiporter
GO004_RS08880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_RS08885	COG0726	polysaccharide deacetylase
GO004_RS08890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO004_RS08895	COG0668	transmembrane transport
GO004_RS08905	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_RS08910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO004_RS08915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO004_RS08920	COG1253	flavin adenine dinucleotide binding
GO004_RS08925	COG0436	Aminotransferase
GO004_RS08930	COG0789	Transcriptional regulator
GO004_RS08935	COG1253	flavin adenine dinucleotide binding
GO004_RS08940	COG0204	Acyl-transferase
GO004_RS08945	COG0667	Aldo Keto reductase
GO004_RS08950	COG1595	DNA-templated transcription, initiation
GO004_RS08965	COG0456	acetyltransferase
GO004_RS08970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS08975	COG0733	neurotransmitter:sodium symporter activity
GO004_RS08980	COG0531	amino acid
GO004_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS08990	COG0372	Belongs to the citrate synthase family
GO004_RS08995	COG0583	DNA-binding transcription factor activity
GO004_RS09000	COG1388	LysM domain
GO004_RS09000	COG0791	NLP P60 protein
GO004_RS09005	COG1785	Belongs to the alkaline phosphatase family
GO004_RS09010	COG2719	SpoVR family
GO004_RS09015	COG0668	transmembrane transport
GO004_RS09020	COG1959	2 iron, 2 sulfur cluster binding
GO004_RS09025	COG0791	NLP P60 protein
GO004_RS09025	COG1388	LysM domain
GO004_RS09040	COG0431	NADPH-dependent FMN reductase
GO004_RS09045	COG2197	response regulator
GO004_RS09050	COG4585	Histidine kinase
GO004_RS09050	COG2203	Gaf domain
GO004_RS09055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO004_RS09060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO004_RS09065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO004_RS09070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO004_RS09075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GO004_RS09080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_RS09085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO004_RS09085	COG3153	acetyltransferase
GO004_RS09090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO004_RS09095	COG0517	IMP dehydrogenase activity
GO004_RS09105	COG0564	pseudouridine synthase activity
GO004_RS09110	COG3764	Sortase (surface protein transpeptidase)
GO004_RS09115	COG1525	nuclease
GO004_RS09115	COG0737	Belongs to the 5'-nucleotidase family
GO004_RS09115	COG4085	toxin activity
GO004_RS09120	COG5577	PFAM Coat F domain
GO004_RS09140	COG1823	symporter activity
GO004_RS09145	COG3706	GGDEF domain
GO004_RS09150	COG1464	Belongs to the NlpA lipoprotein family
GO004_RS09155	COG1278	Cold shock
GO004_RS09160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_RS09165	COG1131	(ABC) transporter
GO004_RS09170	COG1131	(ABC) transporter
GO004_RS09175	COG1725	Transcriptional regulator
GO004_RS09195	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO004_RS09200	COG2814	Major facilitator Superfamily
GO004_RS09205	COG1566	PFAM secretion protein HlyD family protein
GO004_RS09210	COG1846	Transcriptional regulator
GO004_RS09215	COG2718	Belongs to the UPF0229 family
GO004_RS09220	COG2766	serine protein kinase
GO004_RS09225	COG1664	Polymer-forming cytoskeletal
GO004_RS09230	COG1664	Polymer-forming cytoskeletal
GO004_RS09235	COG0789	Transcriptional regulator
GO004_RS09240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO004_RS09250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO004_RS09255	COG3382	B3 4 domain protein
GO004_RS09265	COG1476	TRANSCRIPTIONal
GO004_RS09275	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO004_RS09285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS09290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO004_RS09295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO004_RS09300	COG1116	anion transmembrane transporter activity
GO004_RS09305	COG0753	catalase activity
GO004_RS09315	COG0277	FAD linked oxidase domain protein
GO004_RS09320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO004_RS09330	COG5577	PFAM Coat F domain
GO004_RS09340	COG4326	sporulation control protein
GO004_RS09450	COG0735	belongs to the Fur family
GO004_RS09455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO004_RS09460	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO004_RS09465	COG4129	membrane
GO004_RS09470	COG1132	(ABC) transporter
GO004_RS09475	COG3557	Belongs to the UPF0374 family
GO004_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS09500	COG1194	a g-specific adenine glycosylase
GO004_RS09505	COG1988	membrane-bound metal-dependent
GO004_RS09510	COG4485	Bacterial membrane protein, YfhO
GO004_RS09515	COG0463	Glycosyl transferase, family 2
GO004_RS09520	COG0596	Alpha beta hydrolase
GO004_RS09525	COG5658	integral membrane protein
GO004_RS09545	COG2814	Major facilitator Superfamily
GO004_RS09555	COG2137	regulation of response to DNA damage stimulus
GO004_RS09560	COG1090	epimerase
GO004_RS09575	COG0778	Nitroreductase
GO004_RS09580	COG0384	phenazine biosynthesis protein PhzF
GO004_RS09585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS09590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS09595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS09600	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GO004_RS09600	COG0392	lysyltransferase activity
GO004_RS09605	COG1846	Transcriptional regulator
GO004_RS09610	COG2814	Major facilitator Superfamily
GO004_RS09615	COG2318	DinB family
GO004_RS09620	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GO004_RS09625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO004_RS09630	COG1695	Transcriptional regulator
GO004_RS09635	COG0842	Transport permease protein
GO004_RS09640	COG1511	domain protein
GO004_RS09640	COG0842	Transport permease protein
GO004_RS09645	COG1131	(ABC) transporter
GO004_RS09650	COG2197	response regulator
GO004_RS09655	COG4585	Histidine kinase
GO004_RS09660	COG2514	catechol 2,3-dioxygenase activity
GO004_RS09665	COG2259	Doxx family
GO004_RS09670	COG1132	(ABC) transporter
GO004_RS09675	COG1132	(ABC) transporter
GO004_RS09680	COG1263	PTS System
GO004_RS09680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS09685	COG1737	Transcriptional regulator
GO004_RS09690	COG1486	melibiose metabolic process
GO004_RS09695	COG4842	Belongs to the WXG100 family
GO004_RS09715	COG1742	UPF0060 membrane protein
GO004_RS09725	COG3284	Transcriptional regulator
GO004_RS09730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_RS09735	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_RS09740	COG0022	dehydrogenase e1 component
GO004_RS09745	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_RS09750	COG4637	Psort location Cytoplasmic, score
GO004_RS09755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO004_RS09765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO004_RS09770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO004_RS09775	COG0598	Magnesium transport protein CorA
GO004_RS09780	COG2084	Dehydrogenase
GO004_RS09785	COG0726	polysaccharide deacetylase
GO004_RS09795	COG0535	radical SAM domain protein
GO004_RS09800	COG0668	transmembrane transport
GO004_RS09810	COG0387	Pfam Sodium calcium exchanger
GO004_RS09815	COG0477	Major facilitator Superfamily
GO004_RS09820	COG1295	ribonuclease BN
GO004_RS09825	COG4980	gas vesicle protein
GO004_RS09830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_RS09835	COG4840	Belongs to the UPF0435 family
GO004_RS09840	COG2814	Major facilitator Superfamily
GO004_RS09845	COG0693	protein deglycase activity
GO004_RS09850	COG0737	Belongs to the 5'-nucleotidase family
GO004_RS09855	COG0778	Nitroreductase
GO004_RS09860	COG2188	Transcriptional regulator
GO004_RS09865	COG0366	Alpha amylase catalytic
GO004_RS09870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS09870	COG1263	PTS System
GO004_RS09875	COG0697	spore germination
GO004_RS09890	COG0531	amino acid
GO004_RS09895	COG1115	amino acid carrier protein
GO004_RS09910	COG1368	sulfuric ester hydrolase activity
GO004_RS09915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS09915	COG1263	PTS System
GO004_RS09920	COG0024	Methionine aminopeptidase
GO004_RS09940	COG2258	MOSC domain
GO004_RS09945	COG1254	Belongs to the acylphosphatase family
GO004_RS09950	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GO004_RS09955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS09960	COG2851	Citrate transporter
GO004_RS09965	COG3181	Tripartite tricarboxylate transporter family receptor
GO004_RS09970	COG4565	transcriptional regulatory protein
GO004_RS09975	COG3290	protein histidine kinase activity
GO004_RS09980	COG0471	metal ion transport
GO004_RS09985	COG3866	Pectate lyase
GO004_RS10000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO004_RS10005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS10010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS10015	COG1120	ATPase activity
GO004_RS10020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO004_RS10025	COG2211	Major facilitator Superfamily
GO004_RS10030	COG2130	NADP-dependent
GO004_RS10035	COG0456	acetyltransferase
GO004_RS10040	COG0513	Belongs to the DEAD box helicase family
GO004_RS10045	COG0488	(ABC) transporter
GO004_RS10055	COG2814	Major facilitator Superfamily
GO004_RS10060	COG0789	Transcriptional regulator
GO004_RS10070	COG0488	(ABC) transporter
GO004_RS10075	COG0840	transmembrane signaling receptor activity
GO004_RS10080	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS10085	COG0531	amino acid
GO004_RS10090	COG1011	Hydrolase
GO004_RS10095	COG2223	nitrite transmembrane transporter activity
GO004_RS10100	COG1442	glycosyl transferase family 8
GO004_RS10105	COG1216	Glycosyl transferase, family 2
GO004_RS10110	COG1442	glycosyl transferase family 8
GO004_RS10115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_RS10120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO004_RS10125	COG1368	sulfuric ester hydrolase activity
GO004_RS10130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_RS10130	COG2124	cytochrome p450
GO004_RS10145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO004_RS10150	COG1846	Transcriptional regulator
GO004_RS10155	COG0697	spore germination
GO004_RS10160	COG0670	Belongs to the BI1 family
GO004_RS10165	COG5583	Uncharacterized small protein (DUF2292)
GO004_RS10180	COG0346	lactoylglutathione lyase activity
GO004_RS10185	COG2329	Antibiotic biosynthesis monooxygenase
GO004_RS10190	COG2323	membrane
GO004_RS10195	COG1486	melibiose metabolic process
GO004_RS10200	COG0395	ABC-type sugar transport system, permease component
GO004_RS10205	COG4209	transmembrane transport
GO004_RS10210	COG1653	transport
GO004_RS10220	COG1874	Beta-galactosidase
GO004_RS10225	COG2755	lipolytic protein G-D-S-L family
GO004_RS10230	COG3401	FG-GAP repeat protein
GO004_RS10235	COG3401	FG-GAP repeat protein
GO004_RS10240	COG5578	integral membrane protein
GO004_RS10250	COG2755	lipolytic protein G-D-S-L family
GO004_RS10255	COG2207	Transcriptional regulator
GO004_RS10260	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO004_RS10265	COG0395	ABC-type sugar transport system, permease component
GO004_RS10270	COG1175	transmembrane transport
GO004_RS10275	COG1653	transport
GO004_RS10280	COG2207	Transcriptional regulator
GO004_RS10280	COG4753	response regulator
GO004_RS10285	COG2972	Histidine kinase
GO004_RS10290	COG5578	integral membrane protein
GO004_RS10300	COG0454	-acetyltransferase
GO004_RS10305	COG3546	catalase activity
GO004_RS10320	COG0702	epimerase
GO004_RS10325	COG3631	Ketosteroid isomerase-related protein
GO004_RS10330	COG1309	transcriptional regulator
GO004_RS10340	COG0217	transcriptional regulatory protein
GO004_RS10350	COG0457	Tetratricopeptide repeat
GO004_RS10355	COG3391	amine dehydrogenase activity
GO004_RS10360	COG3586	endonuclease activity
GO004_RS10370	COG5444	nuclease activity
GO004_RS10385	COG0457	Tetratricopeptide repeat
GO004_RS10415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO004_RS10420	COG1597	lipid kinase activity
GO004_RS10425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO004_RS10430	COG1309	transcriptional regulator
GO004_RS10435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO004_RS10440	COG0154	amidase activity
GO004_RS10445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO004_RS10450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_RS10455	COG1285	pathogenesis
GO004_RS10460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_RS10465	COG4851	CamS sex pheromone cAM373 precursor
GO004_RS10470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO004_RS10475	COG0210	DNA helicase
GO004_RS10480	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GO004_RS10485	COG0069	glutamate synthase activity
GO004_RS10490	COG4496	protein, YerC YecD
GO004_RS10495	COG1470	cell adhesion involved in biofilm formation
GO004_RS10500	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO004_RS10510	COG0531	amino acid
GO004_RS10515	COG1522	sequence-specific DNA binding
GO004_RS10520	COG0151	Belongs to the GarS family
GO004_RS10525	COG0138	bifunctional purine biosynthesis protein purh
GO004_RS10530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO004_RS10535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO004_RS10540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO004_RS10545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO004_RS10550	COG0047	phosphoribosylformylglycinamidine synthase activity
GO004_RS10555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO004_RS10560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO004_RS10565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO004_RS10570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO004_RS10575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO004_RS10585	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GO004_RS10595	COG3064	Membrane
GO004_RS10600	COG2252	PERMEase
GO004_RS10615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO004_RS10615	COG0519	Catalyzes the synthesis of GMP from XMP
GO004_RS10620	COG1305	Transglutaminase-like
GO004_RS10625	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GO004_RS10630	COG0714	Associated with various cellular activities
GO004_RS10635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_RS10645	COG1113	amino acid transport
GO004_RS10650	COG2132	Multicopper oxidase
GO004_RS10660	COG2267	carboxylic ester hydrolase activity
GO004_RS10675	COG0823	Involved in the tonB-independent uptake of proteins
GO004_RS10680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO004_RS10685	COG1063	alcohol dehydrogenase
GO004_RS10690	COG2814	Major facilitator Superfamily
GO004_RS10700	COG4260	virion core protein, lumpy skin disease virus
GO004_RS10705	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO004_RS10710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO004_RS10715	COG1842	Phage shock protein A
GO004_RS10720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_RS10725	COG2211	Major facilitator Superfamily
GO004_RS10730	COG1063	alcohol dehydrogenase
GO004_RS10735	COG0457	Tetratricopeptide repeat
GO004_RS10740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GO004_RS10760	COG2322	membrane
GO004_RS10770	COG5444	nuclease activity
GO004_RS10785	COG0459	protein refolding
GO004_RS10795	COG1266	CAAX protease self-immunity
GO004_RS10805	COG0805	protein transport
GO004_RS10810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_RS10815	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GO004_RS10820	COG0315	cyclic pyranopterin monophosphate synthase activity
GO004_RS10825	COG0488	(ABC) transporter
GO004_RS10830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO004_RS10835	COG0456	acetyltransferase
GO004_RS10840	COG1214	PFAM Peptidase M22, glycoprotease
GO004_RS10845	COG0802	atpase or kinase
GO004_RS10850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO004_RS10895	COG4124	Belongs to the glycosyl hydrolase 26 family
GO004_RS10900	COG1482	cell wall glycoprotein biosynthetic process
GO004_RS10905	COG1940	carbohydrate kinase activity
GO004_RS10910	COG2188	Transcriptional regulator
GO004_RS10915	COG2723	6-phospho-beta-galactosidase activity
GO004_RS10920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_RS10925	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO004_RS10930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_RS10935	COG2814	Major facilitator Superfamily
GO004_RS10940	COG1388	LysM domain
GO004_RS10945	COG1078	dGTPase activity
GO004_RS10950	COG0454	-acetyltransferase
GO004_RS10960	COG5646	InterPro IPR014922
GO004_RS10965	COG1785	Belongs to the alkaline phosphatase family
GO004_RS10975	COG1819	glycosyl
GO004_RS10980	COG3858	chitin binding
GO004_RS10980	COG1388	LysM domain
GO004_RS10985	COG1802	Transcriptional regulator
GO004_RS10990	COG0730	response to heat
GO004_RS10995	COG2814	Major facilitator Superfamily
GO004_RS11000	COG1846	Transcriptional regulator
GO004_RS11005	COG0778	Nitroreductase
GO004_RS11010	COG1033	growth of symbiont in host cell
GO004_RS11010	COG2409	Drug exporters of the RND superfamily
GO004_RS11015	COG1846	Transcriptional regulator
GO004_RS11020	COG2318	DinB family
GO004_RS11025	COG1113	amino acid transport
GO004_RS11030	COG0488	(ABC) transporter
GO004_RS11045	COG1309	transcriptional regulator
GO004_RS11060	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_RS11065	COG2323	membrane
GO004_RS11070	COG2323	membrane
GO004_RS11090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS11095	COG2259	Doxx family
GO004_RS11100	COG0346	lactoylglutathione lyase activity
GO004_RS11105	COG0778	Nitroreductase
GO004_RS11110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_RS11115	COG0789	Transcriptional regulator
GO004_RS11115	COG4978	Transcriptional regulator
GO004_RS11120	COG1811	Na channel or pump
GO004_RS11125	COG0596	Alpha beta hydrolase
GO004_RS11130	COG2409	Drug exporters of the RND superfamily
GO004_RS11135	COG2197	response regulator
GO004_RS11140	COG4585	Histidine kinase
GO004_RS11155	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO004_RS11160	COG0640	Transcriptional regulator
GO004_RS11165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO004_RS11170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS11175	COG0697	spore germination
GO004_RS11180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS11190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO004_RS11195	COG0640	Transcriptional regulator
GO004_RS11200	COG1309	transcriptional regulator
GO004_RS11205	COG2814	Major facilitator Superfamily
GO004_RS11210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS11215	COG1733	regulation of RNA biosynthetic process
GO004_RS11220	COG3545	Serine hydrolase
GO004_RS11225	COG2030	dehydratase
GO004_RS11230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS11235	COG0697	spore germination
GO004_RS11240	COG1309	transcriptional regulator
GO004_RS11245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS11255	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GO004_RS11265	COG0477	Major facilitator Superfamily
GO004_RS11270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS11275	COG3708	Transcriptional regulator
GO004_RS11275	COG2207	Transcriptional regulator
GO004_RS11280	COG0697	spore germination
GO004_RS11285	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS11285	COG2207	Transcriptional regulator
GO004_RS11290	COG0697	spore germination
GO004_RS11295	COG1329	Transcriptional regulator
GO004_RS11300	COG1278	Cold shock
GO004_RS11305	COG3239	Fatty acid desaturase
GO004_RS11315	COG1476	TRANSCRIPTIONal
GO004_RS11320	COG5444	nuclease activity
GO004_RS11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS11370	COG3091	SprT-like family
GO004_RS11380	COG2183	response to ionizing radiation
GO004_RS11385	COG2208	phosphoserine phosphatase activity
GO004_RS11390	COG1191	sigma factor activity
GO004_RS11395	COG2172	sigma factor antagonist activity
GO004_RS11400	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS11405	COG2208	phosphoserine phosphatase activity
GO004_RS11410	COG2172	sigma factor antagonist activity
GO004_RS11415	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS11420	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS11425	COG2337	Toxic component of a toxin-antitoxin (TA) module
GO004_RS11430	COG0864	Transcriptional regulator
GO004_RS11435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO004_RS11440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO004_RS11445	COG0736	holo-[acyl-carrier-protein] synthase activity
GO004_RS11450	COG0705	Rhomboid family
GO004_RS11455	COG3428	Bacterial PH domain
GO004_RS11460	COG3402	PFAM membrane-flanked domain
GO004_RS11465	COG0513	Belongs to the DEAD box helicase family
GO004_RS11470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO004_RS11475	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO004_RS11480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS11485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_RS11500	COG1960	acyl-CoA dehydrogenase activity
GO004_RS11510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_RS11515	COG1131	(ABC) transporter
GO004_RS11520	COG0628	permease
GO004_RS11525	COG1301	dicarboxylic acid transport
GO004_RS11530	COG4565	transcriptional regulatory protein
GO004_RS11535	COG3290	protein histidine kinase activity
GO004_RS11540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO004_RS11545	COG3546	catalase activity
GO004_RS11550	COG2329	Antibiotic biosynthesis monooxygenase
GO004_RS11555	COG0662	Cupin 2, conserved barrel domain protein
GO004_RS11560	COG3729	General stress protein
GO004_RS11565	COG2217	Heavy metal translocating P-type atpase
GO004_RS11570	COG4876	unkown
GO004_RS11575	COG2261	transglycosylase associated protein
GO004_RS11580	COG1914	H( )-stimulated, divalent metal cation uptake system
GO004_RS11605	COG0028	Belongs to the TPP enzyme family
GO004_RS11610	COG0494	nUDIX hydrolase
GO004_RS11615	COG0531	amino acid
GO004_RS11625	COG1215	transferase activity, transferring glycosyl groups
GO004_RS11635	COG3706	GGDEF domain
GO004_RS11640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GO004_RS11645	COG0551	DNA topoisomerase type I activity
GO004_RS11645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO004_RS11650	COG1522	sequence-specific DNA binding
GO004_RS11655	COG2814	Major facilitator Superfamily
GO004_RS11665	COG3871	stress protein (general stress protein 26)
GO004_RS11670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS11675	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS11685	COG2226	methyltransferase
GO004_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS11695	COG3711	transcriptional antiterminator
GO004_RS11700	COG4989	oxidoreductase activity
GO004_RS11705	COG0768	penicillin binding
GO004_RS11710	COG2329	Antibiotic biosynthesis monooxygenase
GO004_RS11720	COG2755	lipolytic protein G-D-S-L family
GO004_RS11725	COG1414	Transcriptional regulator
GO004_RS11730	COG1984	allophanate hydrolase subunit 2
GO004_RS11735	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GO004_RS11740	COG4336	lyase activity
GO004_RS11745	COG1914	H( )-stimulated, divalent metal cation uptake system
GO004_RS11750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO004_RS11755	COG0561	phosphatase activity
GO004_RS11765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO004_RS11770	COG0412	Dienelactone hydrolase
GO004_RS11775	COG0681	Belongs to the peptidase S26 family
GO004_RS11780	COG0473	3-isopropylmalate dehydrogenase activity
GO004_RS11785	COG0246	Mannitol dehydrogenase
GO004_RS11790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS11795	COG2213	PTS system mannitol-specific
GO004_RS11805	COG1349	DNA-binding transcription factor activity
GO004_RS11810	COG1276	copper resistance
GO004_RS11810	COG2372	response to copper ion
GO004_RS11815	COG4549	nuclear export factor GLE1
GO004_RS11820	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS11825	COG4975	Glucose uptake
GO004_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS11835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO004_RS11840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS11845	COG0640	Transcriptional regulator
GO004_RS11850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO004_RS11855	COG0778	Nitroreductase
GO004_RS11860	COG1309	transcriptional regulator
GO004_RS11865	COG2814	Major facilitator Superfamily
GO004_RS11870	COG4607	ABC-type enterochelin transport system periplasmic component
GO004_RS11875	COG4604	ABC transporter, ATP-binding protein
GO004_RS11880	COG4605	iron ion homeostasis
GO004_RS11885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS11890	COG0527	aspartate kinase activity
GO004_RS11910	COG0457	Tetratricopeptide repeat
GO004_RS11915	COG3850	Histidine kinase
GO004_RS11915	COG5002	protein histidine kinase activity
GO004_RS11920	COG0745	RESPONSE REGULATOR receiver
GO004_RS11925	COG0577	efflux transmembrane transporter activity
GO004_RS11930	COG1136	(ABC) transporter
GO004_RS11935	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO004_RS11945	COG0697	spore germination
GO004_RS11955	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_RS11960	COG3104	oligopeptide transport
GO004_RS11965	COG0596	Alpha beta hydrolase
GO004_RS11980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO004_RS11985	COG0163	prenyltransferase activity
GO004_RS11990	COG0583	DNA-binding transcription factor activity
GO004_RS11995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS12000	COG0765	amino acid transport
GO004_RS12005	COG1126	abc transporter atp-binding protein
GO004_RS12010	COG2364	Membrane
GO004_RS12020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_RS12025	COG0697	spore germination
GO004_RS12035	COG2814	Major facilitator Superfamily
GO004_RS12040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GO004_RS12045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS12050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS12055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS12060	COG1733	regulation of RNA biosynthetic process
GO004_RS12065	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GO004_RS12070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO004_RS12075	COG0840	transmembrane signaling receptor activity
GO004_RS12075	COG3290	protein histidine kinase activity
GO004_RS12080	COG3209	COG3209 Rhs family protein
GO004_RS12090	COG2723	6-phospho-beta-galactosidase activity
GO004_RS12100	COG1714	RDD family
GO004_RS12110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS12115	COG0765	amino acid transport
GO004_RS12135	COG1469	GTP cyclohydrolase I activity
GO004_RS12140	COG2223	nitrite transmembrane transporter activity
GO004_RS12145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_RS12150	COG0243	molybdopterin cofactor binding
GO004_RS12155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_RS12160	COG2146	nitrite reductase [NAD(P)H] activity
GO004_RS12165	COG1587	Uroporphyrinogen-III synthase
GO004_RS12165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO004_RS12170	COG0492	ferredoxin-NADP+ reductase activity
GO004_RS12175	COG2267	carboxylic ester hydrolase activity
GO004_RS12180	COG0701	Predicted permease
GO004_RS12185	COG3689	TIGRFAM TIGR03943 family protein
GO004_RS12190	COG2508	Transcriptional regulator
GO004_RS12195	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_RS12200	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS12205	COG0506	proline dehydrogenase activity
GO004_RS12210	COG3541	Predicted nucleotidyltransferase
GO004_RS12215	COG3458	cephalosporin-C deacetylase activity
GO004_RS12220	COG0583	DNA-binding transcription factor activity
GO004_RS12225	COG2226	methyltransferase
GO004_RS12230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO004_RS12235	COG1660	Displays ATPase and GTPase activities
GO004_RS12240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO004_RS12245	COG3665	Urea carboxylase-associated protein
GO004_RS12250	COG1113	amino acid transport
GO004_RS12255	COG3403	YqcI/YcgG family
GO004_RS12260	COG1280	lysine exporter protein (LysE YggA)
GO004_RS12265	COG1846	Transcriptional regulator
GO004_RS12270	COG2814	Major facilitator Superfamily
GO004_RS12275	COG1620	l-lactate permease
GO004_RS12280	COG0039	L-malate dehydrogenase activity
GO004_RS12285	COG0366	Alpha amylase catalytic
GO004_RS12295	COG1288	antiporter activity
GO004_RS12300	COG1473	amidohydrolase
GO004_RS12305	COG2113	Glycine betaine
GO004_RS12310	COG4176	ABC-type proline glycine betaine transport system permease component
GO004_RS12315	COG4175	Glycine betaine
GO004_RS12315	COG0517	IMP dehydrogenase activity
GO004_RS12320	COG0640	Transcriptional regulator
GO004_RS12325	COG2814	Major facilitator Superfamily
GO004_RS12330	COG0477	Major facilitator Superfamily
GO004_RS12335	COG3853	Toxic anion resistance protein (TelA)
GO004_RS12345	COG0861	Integral membrane protein TerC family
GO004_RS12350	COG2310	stress, protein
GO004_RS12355	COG2310	stress, protein
GO004_RS12360	COG2310	stress, protein
GO004_RS12365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS12370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_RS12375	COG1121	(ABC) transporter
GO004_RS12380	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO004_RS12385	COG0366	Alpha amylase catalytic
GO004_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS12395	COG0457	Tetratricopeptide repeat
GO004_RS12400	COG1876	peptidase activity
GO004_RS12405	COG1595	DNA-templated transcription, initiation
GO004_RS12410	COG1595	DNA-templated transcription, initiation
GO004_RS12425	COG0667	Aldo Keto reductase
GO004_RS12430	COG1668	transmembrane transport
GO004_RS12435	COG4555	ABC transporter
GO004_RS12440	COG3279	Response regulator of the LytR AlgR family
GO004_RS12445	COG3290	protein histidine kinase activity
GO004_RS12450	COG1405	negative regulation of cell septum assembly
GO004_RS12450	COG3012	SEC-C Motif Domain Protein
GO004_RS12455	COG1714	RDD family
GO004_RS12460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO004_RS12465	COG0252	asparaginase activity
GO004_RS12470	COG1309	transcriptional regulator
GO004_RS12475	COG0477	Major facilitator Superfamily
GO004_RS12480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO004_RS12485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GO004_RS12490	COG0805	protein transport
GO004_RS12495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_RS12500	COG3540	Alkaline phosphatase
GO004_RS12510	COG2304	oxidoreductase activity
GO004_RS12515	COG3773	Cell wall hydrolase
GO004_RS12535	COG1131	(ABC) transporter
GO004_RS12540	COG2205	protein histidine kinase activity
GO004_RS12545	COG0745	RESPONSE REGULATOR receiver
GO004_RS12550	COG0697	spore germination
GO004_RS12560	COG3173	Aminoglycoside phosphotransferase
GO004_RS12565	COG2721	sulfolactate sulfo-lyase activity
GO004_RS12570	COG2186	Transcriptional regulator
GO004_RS12575	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_RS12580	COG2271	Major facilitator Superfamily
GO004_RS12585	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS12590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO004_RS12595	COG0784	Response regulator, receiver
GO004_RS12600	COG4191	Histidine kinase
GO004_RS12605	COG2066	Belongs to the glutaminase family
GO004_RS12610	COG1115	amino acid carrier protein
GO004_RS12615	COG2040	homocysteine
GO004_RS12620	COG0833	amino acid
GO004_RS12625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_RS12635	COG2188	Transcriptional regulator
GO004_RS12640	COG0363	glucosamine-6-phosphate deaminase activity
GO004_RS12645	COG1263	PTS System
GO004_RS12645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS12645	COG2190	(PTS) system
GO004_RS12650	COG1301	dicarboxylic acid transport
GO004_RS12655	COG1054	Belongs to the UPF0176 family
GO004_RS12660	COG2312	Erythromycin esterase
GO004_RS12670	COG0688	phosphatidylethanolamine metabolic process
GO004_RS12675	COG0586	Pfam SNARE associated Golgi protein
GO004_RS12680	COG1183	phosphatidylcholine synthase activity
GO004_RS12685	COG0596	Alpha beta hydrolase
GO004_RS12695	COG3591	Belongs to the peptidase S1B family
GO004_RS12700	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO004_RS12705	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS12705	COG2207	Transcriptional regulator
GO004_RS12710	COG0697	spore germination
GO004_RS12715	COG2271	Major facilitator Superfamily
GO004_RS12720	COG1846	Transcriptional regulator
GO004_RS12720	COG0456	acetyltransferase
GO004_RS12730	COG2271	Major facilitator Superfamily
GO004_RS12735	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_RS12745	COG0531	amino acid
GO004_RS12755	COG2124	cytochrome p450
GO004_RS12760	COG2602	Beta-lactamase
GO004_RS12775	COG1113	amino acid transport
GO004_RS12790	COG0515	serine threonine protein kinase
GO004_RS12800	COG0642	Histidine kinase
GO004_RS12805	COG0745	RESPONSE REGULATOR receiver
GO004_RS12810	COG0596	Alpha beta hydrolase
GO004_RS12815	COG1132	(ABC) transporter
GO004_RS12835	COG1404	Belongs to the peptidase S8 family
GO004_RS12850	COG2814	Major facilitator Superfamily
GO004_RS12855	COG0640	Transcriptional regulator
GO004_RS12860	COG5609	conserved protein (DUF2294)
GO004_RS12870	COG0288	reversible hydration of carbon dioxide
GO004_RS12875	COG3002	Belongs to the UPF0753 family
GO004_RS12880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO004_RS12885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO004_RS12890	COG2169	Transcriptional regulator
GO004_RS12895	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO004_RS12905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO004_RS12910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO004_RS12915	COG4856	YbbR-like protein
GO004_RS12920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO004_RS12925	COG5662	AntiSigma factor
GO004_RS12930	COG1595	DNA-templated transcription, initiation
GO004_RS12960	COG1683	Conserved Protein
GO004_RS12965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_RS12970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO004_RS12975	COG1737	Transcriptional regulator
GO004_RS12980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS12980	COG1263	PTS System
GO004_RS12985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_RS12990	COG1472	Belongs to the glycosyl hydrolase 3 family
GO004_RS12995	COG3876	Protein conserved in bacteria
GO004_RS13000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS13000	COG2207	Transcriptional regulator
GO004_RS13005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS13010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS13015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS13020	COG2819	hydrolase of the alpha beta superfamily
GO004_RS13025	COG0385	Bile acid
GO004_RS13030	COG0659	secondary active sulfate transmembrane transporter activity
GO004_RS13115	COG0726	polysaccharide deacetylase
GO004_RS13120	COG2194	sulfuric ester hydrolase activity
GO004_RS13130	COG0489	protein tyrosine kinase activity
GO004_RS13135	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS13145	COG2226	methyltransferase
GO004_RS13150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO004_RS13155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO004_RS13160	COG0101	tRNA pseudouridine synthase activity
GO004_RS13165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO004_RS13170	COG1122	ATPase activity
GO004_RS13175	COG1122	ATPase activity
GO004_RS13180	COG0203	ribosomal protein L17
GO004_RS13185	COG0202	RNA polymerase activity
GO004_RS13190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO004_RS13195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO004_RS13200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO004_RS13215	COG0024	Methionine aminopeptidase
GO004_RS13220	COG0563	adenylate kinase activity
GO004_RS13225	COG0201	protein transport
GO004_RS13230	COG0200	Binds to the 23S rRNA
GO004_RS13240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO004_RS13245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO004_RS13250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO004_RS13255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO004_RS13265	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO004_RS13275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO004_RS13280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO004_RS13290	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO004_RS13310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO004_RS13320	COG0088	Forms part of the polypeptide exit tunnel
GO004_RS13325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO004_RS13335	COG0596	Alpha beta hydrolase
GO004_RS13340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO004_RS13345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO004_RS13350	COG0049	tRNA binding
GO004_RS13355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO004_RS13360	COG1358	cellular component organization or biogenesis
GO004_RS13365	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO004_RS13370	COG0085	RNA polymerase activity
GO004_RS13375	COG2813	Specifically methylates the guanine in position
GO004_RS13385	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO004_RS13390	COG0081	regulation of translation
GO004_RS13400	COG0250	Participates in transcription elongation, termination and antitermination
GO004_RS13405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO004_RS13415	COG1595	DNA-templated transcription, initiation
GO004_RS13420	COG3688	RNA-binding protein containing a PIN domain
GO004_RS13425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO004_RS13430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GO004_RS13435	COG0215	cysteine-tRNA ligase activity
GO004_RS13440	COG1045	serine acetyltransferase
GO004_RS13445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO004_RS13450	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO004_RS13455	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO004_RS13460	COG4956	integral membrane protein (PIN domain superfamily)
GO004_RS13465	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GO004_RS13470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GO004_RS13475	COG0542	response to heat
GO004_RS13480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GO004_RS13485	COG3880	PFAM UvrB UvrC protein
GO004_RS13490	COG4463	regulation of RNA biosynthetic process
GO004_RS13570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO004_RS13575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO004_RS13580	COG1396	sequence-specific DNA binding
GO004_RS13585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO004_RS13590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO004_RS13595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO004_RS13600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_RS13605	COG0512	Glutamine amidotransferase of anthranilate synthase
GO004_RS13610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO004_RS13615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_RS13620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO004_RS13625	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO004_RS13630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GO004_RS13635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO004_RS13640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GO004_RS13645	COG0037	tRNA processing
GO004_RS13650	COG0515	serine threonine protein kinase
GO004_RS13655	COG2304	oxidoreductase activity
GO004_RS13660	COG2208	phosphoserine phosphatase activity
GO004_RS13675	COG1098	S1 RNA binding domain
GO004_RS13680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO004_RS13695	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO004_RS13700	COG3956	TIGRFAM MazG family protein
GO004_RS13705	COG2244	polysaccharide biosynthetic process
GO004_RS13710	COG2002	toxin-antitoxin pair type II binding
GO004_RS13715	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO004_RS13725	COG0193	aminoacyl-tRNA hydrolase activity
GO004_RS13730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO004_RS13735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO004_RS13740	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO004_RS13745	COG2088	sporulation resulting in formation of a cellular spore
GO004_RS13750	COG0251	oxidation-reduction process
GO004_RS13755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_RS13760	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO004_RS13770	COG4466	Protein conserved in bacteria
GO004_RS13780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO004_RS13785	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO004_RS13790	COG3583	domain protein
GO004_RS13790	COG3584	3D domain protein
GO004_RS13795	COG0084	hydrolase, TatD family'
GO004_RS13800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_RS13800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_RS13805	COG2002	toxin-antitoxin pair type II binding
GO004_RS13810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO004_RS13815	COG2827	Endonuclease containing a URI domain
GO004_RS13820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO004_RS13825	COG4467	Involved in initiation control of chromosome replication
GO004_RS13830	COG1774	PSP1 C-terminal conserved region
GO004_RS13835	COG0470	DNA polymerase III
GO004_RS13840	COG1728	Protein conserved in bacteria
GO004_RS13845	COG3870	Protein conserved in bacteria
GO004_RS13850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO004_RS13855	COG1982	Orn Lys Arg decarboxylase major
GO004_RS13860	COG3853	Toxic anion resistance protein (TelA)
GO004_RS13865	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GO004_RS13910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO004_RS13915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO004_RS13920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO004_RS13930	COG0590	tRNA wobble adenosine to inosine editing
GO004_RS13935	COG1335	isochorismatase
GO004_RS13940	COG1388	LysM domain
GO004_RS13940	COG3858	chitin binding
GO004_RS13945	COG1428	Deoxynucleoside kinase
GO004_RS13950	COG1428	Deoxynucleoside kinase
GO004_RS13960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO004_RS13965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GO004_RS13970	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GO004_RS13975	COG1686	Belongs to the peptidase S11 family
GO004_RS13980	COG0516	GMP reductase activity
GO004_RS13980	COG0517	IMP dehydrogenase activity
GO004_RS14015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO004_RS14020	COG0187	DNA topoisomerase II activity
GO004_RS14030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO004_RS14035	COG2501	S4 domain
GO004_RS14040	COG0592	DNA-directed DNA polymerase activity
GO004_RS14045	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO004_RS14055	COG0594	ribonuclease P activity
GO004_RS14060	COG0706	membrane insertase activity
GO004_RS14065	COG1847	R3H domain protein
GO004_RS14070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO004_RS14075	COG0445	tRNA wobble uridine modification
GO004_RS14080	COG0357	Ribosomal RNA small subunit methyltransferase G
GO004_RS14085	COG1475	DNA binding
GO004_RS14095	COG1192	Involved in chromosome partitioning
GO004_RS14100	COG1475	DNA binding
GO004_RS14110	COG3949	Membrane
GO004_RS14115	COG4481	Protein conserved in bacteria
GO004_RS14120	COG0243	molybdopterin cofactor binding
GO004_RS14125	COG0012	GTP binding
GO004_RS14130	COG0360	Binds together with S18 to 16S ribosomal RNA
GO004_RS14135	COG0629	single-stranded DNA binding
GO004_RS14140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO004_RS14145	COG0708	Exodeoxyribonuclease III
GO004_RS14150	COG1609	Transcriptional regulator
GO004_RS14155	COG0346	lactoylglutathione lyase activity
GO004_RS14160	COG0110	maltose O-acetyltransferase activity
GO004_RS14165	COG2814	Major facilitator Superfamily
GO004_RS14165	COG0477	Major facilitator Superfamily
GO004_RS14170	COG1266	CAAX protease self-immunity
GO004_RS14175	COG1331	Highly conserved protein containing a thioredoxin domain
GO004_RS14185	COG2814	Major facilitator Superfamily
GO004_RS14195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_RS14200	COG2315	Protein conserved in bacteria
GO004_RS14205	COG0456	acetyltransferase
GO004_RS14210	COG2364	Membrane
GO004_RS14215	COG2153	protein acetylation
GO004_RS14220	COG1846	Transcriptional regulator
GO004_RS14225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS14235	COG2153	protein acetylation
GO004_RS14240	COG0583	DNA-binding transcription factor activity
GO004_RS14245	COG2814	Major facilitator Superfamily
GO004_RS14250	COG1357	PFAM Pentapeptide repeats (8 copies)
GO004_RS14255	COG4319	ketosteroid isomerase
GO004_RS14265	COG4978	Transcriptional regulator
GO004_RS14265	COG0789	Transcriptional regulator
GO004_RS14270	COG2271	Major facilitator Superfamily
GO004_RS14285	COG1227	inorganic diphosphatase activity
GO004_RS14290	COG1733	regulation of RNA biosynthetic process
GO004_RS14295	COG5577	PFAM Coat F domain
GO004_RS14305	COG4241	membrane
GO004_RS14310	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GO004_RS14315	COG0359	binds to the 23S rRNA
GO004_RS14320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO004_RS14325	COG2807	transmembrane transport
GO004_RS14330	COG3093	addiction module antidote protein HigA
GO004_RS14345	COG0305	Participates in initiation and elongation during chromosome replication
GO004_RS14350	COG0346	lactoylglutathione lyase activity
GO004_RS14380	COG0745	RESPONSE REGULATOR receiver
GO004_RS14385	COG5002	protein histidine kinase activity
GO004_RS14390	COG4863	YycH protein
GO004_RS14395	COG4853	Protein conserved in bacteria
GO004_RS14400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GO004_RS14405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_RS14420	COG3829	transcription factor binding
GO004_RS14425	COG0640	Transcriptional regulator
GO004_RS14430	COG5658	integral membrane protein
GO004_RS14450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO004_RS14455	COG0833	amino acid
GO004_RS14460	COG0010	Belongs to the arginase family
GO004_RS14470	COG0457	Tetratricopeptide repeat
GO004_RS14475	COG0456	acetyltransferase
GO004_RS14480	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GO004_RS14500	COG1063	alcohol dehydrogenase
GO004_RS14515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO004_RS14530	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GO004_RS14545	COG3634	alkyl hydroperoxide reductase activity
GO004_RS14550	COG0450	alkyl hydroperoxide reductase
GO004_RS14555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO004_RS14560	COG2610	gluconate transmembrane transporter activity
GO004_RS14565	COG1070	Carbohydrate kinase
GO004_RS14570	COG1802	Transcriptional regulator
GO004_RS14575	COG1929	Belongs to the glycerate kinase type-1 family
GO004_RS14580	COG5039	Polysaccharide pyruvyl transferase
GO004_RS14585	COG1346	cytolysis
GO004_RS14590	COG1380	Effector of murein hydrolase LrgA
GO004_RS14595	COG1846	Transcriptional regulator
GO004_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS14605	COG1309	transcriptional regulator
GO004_RS14610	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS14615	COG2311	Membrane
GO004_RS14620	COG1714	RDD family
GO004_RS14630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO004_RS14635	COG2814	Major facilitator Superfamily
GO004_RS14640	COG0367	asparagine synthase
GO004_RS14655	COG2226	methyltransferase
GO004_RS14660	COG2850	peptidyl-arginine hydroxylation
GO004_RS14665	COG0456	acetyltransferase
GO004_RS14670	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS14675	COG1309	transcriptional regulator
GO004_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS14690	COG0326	Molecular chaperone. Has ATPase activity
GO004_RS14695	COG2814	Major facilitator Superfamily
GO004_RS14710	COG0667	Aldo Keto reductase
GO004_RS14715	COG1349	DNA-binding transcription factor activity
GO004_RS14720	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS14730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_RS14735	COG3962	Belongs to the TPP enzyme family
GO004_RS14740	COG1082	Xylose isomerase domain protein TIM barrel
GO004_RS14745	COG2814	Major facilitator Superfamily
GO004_RS14750	COG0673	inositol 2-dehydrogenase activity
GO004_RS14755	COG1082	Xylose isomerase domain protein TIM barrel
GO004_RS14760	COG1082	Xylose isomerase domain protein TIM barrel
GO004_RS14765	COG0191	fructose-bisphosphate aldolase activity
GO004_RS14770	COG0745	RESPONSE REGULATOR receiver
GO004_RS14775	COG2205	protein histidine kinase activity
GO004_RS14780	COG1136	(ABC) transporter
GO004_RS14785	COG0577	efflux transmembrane transporter activity
GO004_RS14790	COG5294	Protein conserved in bacteria
GO004_RS14795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS14825	COG0561	phosphatase activity
GO004_RS14830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GO004_RS14835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS14840	COG0456	acetyltransferase
GO004_RS14845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS14850	COG0765	amino acid transport
GO004_RS14855	COG1126	abc transporter atp-binding protein
GO004_RS14860	COG1473	amidohydrolase
GO004_RS14865	COG2079	MmgE PrpD family protein
GO004_RS14870	COG3192	ethanolamine utilization protein
GO004_RS14880	COG2390	Transcriptional regulator
GO004_RS14885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO004_RS14890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_RS14895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO004_RS14900	COG0833	amino acid
GO004_RS14905	COG0010	Belongs to the arginase family
GO004_RS14910	COG1228	amidohydrolase
GO004_RS14915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GO004_RS14920	COG2986	histidine ammonia-lyase
GO004_RS14930	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_RS14945	COG5444	nuclease activity
GO004_RS14960	COG1263	PTS System
GO004_RS14960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS14960	COG2190	(PTS) system
GO004_RS14965	COG2723	6-phospho-beta-galactosidase activity
GO004_RS14970	COG0589	response to stress
GO004_RS14975	COG0697	spore germination
GO004_RS14980	COG3209	COG3209 Rhs family protein
GO004_RS15040	COG2755	lipolytic protein G-D-S-L family
GO004_RS15040	COG3401	FG-GAP repeat protein
GO004_RS15045	COG0513	Belongs to the DEAD box helicase family
GO004_RS15050	COG2270	Major facilitator Superfamily
GO004_RS15060	COG3711	transcriptional antiterminator
GO004_RS15065	COG2273	Hydrolase Family 16
GO004_RS15070	COG2851	Citrate transporter
GO004_RS15075	COG0753	catalase activity
GO004_RS15075	COG0693	protein deglycase activity
GO004_RS15090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_RS15095	COG0500	methyltransferase
GO004_RS15100	COG2610	gluconate transmembrane transporter activity
GO004_RS15105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO004_RS15110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO004_RS15115	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS15120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_RS15125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_RS15130	COG4894	glucomannan catabolic process
GO004_RS15140	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO004_RS15145	COG2197	response regulator
GO004_RS15150	COG4585	Histidine kinase
GO004_RS15160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO004_RS15170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS15175	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS15180	COG2508	Transcriptional regulator
GO004_RS15185	COG3842	ATPase activity
GO004_RS15190	COG0726	polysaccharide deacetylase
GO004_RS15200	COG0501	Belongs to the peptidase M48B family
GO004_RS15205	COG3493	citrate carrier protein
GO004_RS15210	COG1271	oxidase subunit
GO004_RS15215	COG1294	oxidase, subunit
GO004_RS15220	COG4988	ABC transporter
GO004_RS15225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO004_RS15230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO004_RS15235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO004_RS15240	COG1595	DNA-templated transcription, initiation
GO004_RS15260	COG1131	(ABC) transporter
GO004_RS15265	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_RS15275	COG0753	catalase activity
GO004_RS15280	COG2094	Belongs to the DNA glycosylase MPG family
GO004_RS15290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS15290	COG3711	transcriptional antiterminator
GO004_RS15295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_RS15300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_RS15305	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO004_RS15310	COG1486	melibiose metabolic process
GO004_RS15315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_RS15320	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GO004_RS15325	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GO004_RS15330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_RS15335	COG1696	Membrane protein involved in D-alanine export
GO004_RS15340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS15355	COG1575	Belongs to the MenA family. Type 1 subfamily
GO004_RS15360	COG2357	RelA SpoT domain protein
GO004_RS15365	COG2814	Major facilitator Superfamily
GO004_RS15380	COG2234	aminopeptidase activity
GO004_RS15385	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO004_RS15390	COG1846	Transcriptional regulator
GO004_RS15395	COG5522	Integral membrane protein (intg_mem_TP0381)
GO004_RS15400	COG1442	glycosyl transferase family 8
GO004_RS15405	COG3711	transcriptional antiterminator
GO004_RS15410	COG1263	PTS System
GO004_RS15410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS15415	COG1404	Belongs to the peptidase S8 family
GO004_RS15420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_RS15435	COG0346	lactoylglutathione lyase activity
GO004_RS15440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO004_RS15445	COG4895	conserved protein (DUF2196)
GO004_RS15450	COG2814	Major facilitator Superfamily
GO004_RS15455	COG1346	cytolysis
GO004_RS15460	COG1380	Effector of murein hydrolase LrgA
GO004_RS15465	COG0583	DNA-binding transcription factor activity
GO004_RS15470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GO004_RS15475	COG0352	thiamine-phosphate diphosphorylase activity
GO004_RS15480	COG0672	)-iron permease
GO004_RS15485	COG2822	iron ion transport
GO004_RS15490	COG2837	iron assimilation
GO004_RS15495	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO004_RS15500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_RS15505	COG3162	membrane
GO004_RS15515	COG1309	transcriptional regulator
GO004_RS15520	COG2246	polysaccharide biosynthetic process
GO004_RS15525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO004_RS15530	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GO004_RS15535	COG2261	transglycosylase associated protein
GO004_RS15540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO004_RS15545	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO004_RS15550	COG1845	cytochrome c oxidase, subunit III
GO004_RS15555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO004_RS15565	COG0772	Belongs to the SEDS family
GO004_RS15570	COG0778	Nitroreductase
GO004_RS15575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS15580	COG1404	Belongs to the peptidase S8 family
GO004_RS15590	COG3711	transcriptional antiterminator
GO004_RS15595	COG2116	formate transmembrane transporter activity
GO004_RS15600	COG1263	PTS System
GO004_RS15600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS15605	COG1621	beta-fructofuranosidase activity
GO004_RS15615	COG0351	phosphomethylpyrimidine kinase
GO004_RS15620	COG1216	Glycosyl transferase, family 2
GO004_RS15625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO004_RS15630	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS15640	COG2233	PERMEase
GO004_RS15645	COG2363	Small membrane protein
GO004_RS15655	COG0463	Glycosyl transferase, family 2
GO004_RS15660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_RS15665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_RS15670	COG0456	acetyltransferase
GO004_RS15675	COG2089	acid synthase
GO004_RS15680	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GO004_RS15685	COG3980	spore coat polysaccharide biosynthesis protein
GO004_RS15690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GO004_RS15695	COG1088	dTDP-glucose 4,6-dehydratase activity
GO004_RS15700	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO004_RS15705	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO004_RS15715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_RS15720	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS15725	COG4187	Peptidase family M20/M25/M40
GO004_RS15730	COG0833	amino acid
GO004_RS15735	COG2814	Major facilitator Superfamily
GO004_RS15740	COG0077	Prephenate dehydratase
GO004_RS15745	COG1917	Cupin 2, conserved barrel domain protein
GO004_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS15755	COG0151	Belongs to the GarS family
GO004_RS15760	COG2814	Major facilitator Superfamily
GO004_RS15765	COG0436	Aminotransferase
GO004_RS15770	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS15775	COG3253	May function as heme-dependent peroxidase
GO004_RS15780	COG0280	phosphate acetyltransferase
GO004_RS15785	COG0583	DNA-binding transcription factor activity
GO004_RS15790	COG0095	Lipoate-protein ligase
GO004_RS15795	COG0697	spore germination
GO004_RS15805	COG4844	belongs to the
GO004_RS15810	COG1078	dGTPase activity
GO004_RS15815	COG3465	dGTPase activity
GO004_RS15820	COG1959	2 iron, 2 sulfur cluster binding
GO004_RS15825	COG0477	Major facilitator Superfamily
GO004_RS15835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO004_RS15840	COG1846	Transcriptional regulator
GO004_RS15845	COG1942	4-Oxalocrotonate Tautomerase
GO004_RS15850	COG1994	Peptidase M50
GO004_RS15860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_RS15865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GO004_RS15870	COG0010	Belongs to the arginase family
GO004_RS15880	COG1131	(ABC) transporter
GO004_RS15910	COG0457	Tetratricopeptide repeat
GO004_RS15915	COG3391	amine dehydrogenase activity
GO004_RS15920	COG3391	amine dehydrogenase activity
GO004_RS15930	COG0612	Peptidase, M16
GO004_RS15935	COG0612	Peptidase, M16
GO004_RS15940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO004_RS15945	COG1131	(ABC) transporter
GO004_RS15955	COG0535	radical SAM domain protein
GO004_RS15970	COG4506	Protein conserved in bacteria
GO004_RS15975	COG0018	arginyl-trna synthetase
GO004_RS15980	COG2223	nitrite transmembrane transporter activity
GO004_RS15985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO004_RS15995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO004_RS16000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GO004_RS16005	COG1140	nitrate reductase beta subunit
GO004_RS16010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GO004_RS16015	COG2181	nitrate reductase activity
GO004_RS16020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_RS16025	COG1132	(ABC) transporter
GO004_RS16030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_RS16040	COG4294	response to UV
GO004_RS16045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_RS16050	COG2181	nitrate reductase activity
GO004_RS16050	COG0247	lactate metabolic process
GO004_RS16055	COG1960	acyl-CoA dehydrogenase activity
GO004_RS16060	COG3343	RNA polymerase activity
GO004_RS16065	COG0504	CTP synthase activity
GO004_RS16070	COG4821	SIS domain
GO004_RS16075	COG2204	response regulator
GO004_RS16080	COG0191	fructose-bisphosphate aldolase activity
GO004_RS16085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO004_RS16090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO004_RS16095	COG1494	fructose-1,6-bisphosphatase
GO004_RS16105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO004_RS16115	COG1435	thymidine kinase activity
GO004_RS16120	COG0281	malic enzyme
GO004_RS16125	COG0679	Auxin Efflux Carrier
GO004_RS16130	COG0789	Transcriptional regulator
GO004_RS16135	COG0346	lactoylglutathione lyase activity
GO004_RS16140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO004_RS16145	COG2890	protein-(glutamine-N5) methyltransferase activity
GO004_RS16165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO004_RS16170	COG0009	L-threonylcarbamoyladenylate synthase
GO004_RS16175	COG1971	Probably functions as a manganese efflux pump
GO004_RS16180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_RS16185	COG0698	ribose 5-phosphate isomerase
GO004_RS16190	COG4475	Protein of unknown function (DUF436)
GO004_RS16195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO004_RS16200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO004_RS16210	COG0356	it plays a direct role in the translocation of protons across the membrane
GO004_RS16220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO004_RS16225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO004_RS16230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO004_RS16235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO004_RS16240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO004_RS16245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO004_RS16255	COG4836	Membrane
GO004_RS16265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO004_RS16270	COG2385	sporulation resulting in formation of a cellular spore
GO004_RS16275	COG2304	oxidoreductase activity
GO004_RS16285	COG2304	oxidoreductase activity
GO004_RS16295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO004_RS16300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO004_RS16305	COG0457	Tetratricopeptide repeat
GO004_RS16310	COG1994	Peptidase M50
GO004_RS16315	COG3237	CsbD-like
GO004_RS16330	COG0831	urea catabolic process
GO004_RS16335	COG0832	Belongs to the urease beta subunit family
GO004_RS16340	COG0804	urea catabolic process
GO004_RS16345	COG1959	2 iron, 2 sulfur cluster binding
GO004_RS16350	COG2910	NAD(P)H-binding
GO004_RS16360	COG0789	Transcriptional regulator
GO004_RS16365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_RS16385	COG1247	-acetyltransferase
GO004_RS16390	COG0739	heme binding
GO004_RS16400	COG0671	phosphoesterase, PA-phosphatase related
GO004_RS16405	COG0347	Belongs to the P(II) protein family
GO004_RS16410	COG0004	ammonium transporteR
GO004_RS16420	COG1335	isochorismatase
GO004_RS16425	COG0477	Major facilitator Superfamily
GO004_RS16430	COG1953	Uracil, thiamine, allantoin
GO004_RS16435	COG3420	alginic acid biosynthetic process
GO004_RS16440	COG2814	Major facilitator Superfamily
GO004_RS16445	COG1846	Transcriptional regulator
GO004_RS16455	COG1609	Transcriptional regulator
GO004_RS16460	COG1077	Cell shape determining protein MreB Mrl
GO004_RS16465	COG4786	Flagellar basal body rod
GO004_RS16470	COG4786	Flagellar basal body rod
GO004_RS16475	COG0457	Tetratricopeptide repeat
GO004_RS16480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO004_RS16485	COG1970	mechanosensitive ion channel activity
GO004_RS16490	COG2972	Histidine kinase
GO004_RS16490	COG0745	RESPONSE REGULATOR receiver
GO004_RS16500	COG3764	Sortase (surface protein transpeptidase)
GO004_RS16515	COG0629	single-stranded DNA binding
GO004_RS16520	COG1349	DNA-binding transcription factor activity
GO004_RS16525	COG0561	phosphatase activity
GO004_RS16530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO004_RS16535	COG4715	Zinc finger, swim domain protein
GO004_RS16545	COG3944	biosynthesis protein
GO004_RS16550	COG0489	protein tyrosine kinase activity
GO004_RS16555	COG4464	protein tyrosine phosphatase activity
GO004_RS16560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_RS16565	COG3878	Protein conserved in bacteria
GO004_RS16585	COG5444	nuclease activity
GO004_RS16600	COG0583	DNA-binding transcription factor activity
GO004_RS16605	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO004_RS16615	COG2059	Chromate
GO004_RS16620	COG2059	Chromate
GO004_RS16625	COG1522	sequence-specific DNA binding
GO004_RS16630	COG0405	Gamma-glutamyltransferase
GO004_RS16635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO004_RS16645	COG5337	Spore coat protein CotH
GO004_RS16660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO004_RS16665	COG0583	DNA-binding transcription factor activity
GO004_RS16670	COG0028	Belongs to the TPP enzyme family
GO004_RS16675	COG3527	Alpha-acetolactate decarboxylase
GO004_RS16680	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO004_RS16690	COG3103	Sh3 type 3 domain protein
GO004_RS16695	COG1879	ABC-type sugar transport system periplasmic component
GO004_RS16700	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO004_RS16705	COG1129	ABC transporter
GO004_RS16710	COG1869	D-ribose catabolic process
GO004_RS16715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_RS16720	COG1609	Transcriptional regulator
GO004_RS16725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO004_RS16735	COG2843	Capsule synthesis protein
GO004_RS16745	COG0791	NLP P60 protein
GO004_RS16750	COG0561	phosphatase activity
GO004_RS16755	COG1316	TRANSCRIPTIONal
GO004_RS16760	COG2814	Major facilitator Superfamily
GO004_RS16770	COG0814	amino acid
GO004_RS16775	COG0697	spore germination
GO004_RS16780	COG1482	cell wall glycoprotein biosynthetic process
GO004_RS16785	COG4193	domain, Protein
GO004_RS16795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_RS16800	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO004_RS16805	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO004_RS16810	COG0438	transferase activity, transferring glycosyl groups
GO004_RS16815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_RS16820	COG1682	transport, permease protein
GO004_RS16825	COG1134	teichoic acid transport
GO004_RS16830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_RS16835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO004_RS16840	COG1316	TRANSCRIPTIONal
GO004_RS16850	COG2385	sporulation resulting in formation of a cellular spore
GO004_RS16850	COG2247	cell wall binding repeat
GO004_RS16855	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS16855	COG2247	cell wall binding repeat
GO004_RS16865	COG2244	polysaccharide biosynthetic process
GO004_RS16870	COG0297	glycogen (starch) synthase activity
GO004_RS16870	COG0438	transferase activity, transferring glycosyl groups
GO004_RS16875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_RS16880	COG3307	-O-antigen
GO004_RS16885	COG3206	protein involved in exopolysaccharide biosynthesis
GO004_RS16890	COG1215	transferase activity, transferring glycosyl groups
GO004_RS16895	COG0438	transferase activity, transferring glycosyl groups
GO004_RS16900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO004_RS16905	COG1316	TRANSCRIPTIONal
GO004_RS16910	COG1739	Uncharacterized protein family UPF0029
GO004_RS16915	COG4585	Histidine kinase
GO004_RS16920	COG2197	response regulator
GO004_RS16925	COG1307	EDD domain protein, DegV family
GO004_RS16930	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GO004_RS16940	COG1040	competence protein
GO004_RS16950	COG2747	anti-sigma28 factor FlgM
GO004_RS16955	COG3418	PFAM FlgN family protein
GO004_RS16960	COG1256	bacterial-type flagellum assembly
GO004_RS16960	COG4786	Flagellar basal body rod
GO004_RS16965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO004_RS16975	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GO004_RS16980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO004_RS16985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO004_RS16990	COG1334	flagellar protein FlaG
GO004_RS16995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO004_RS17000	COG1516	flagellar protein fliS
GO004_RS17015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO004_RS17020	COG0653	protein targeting
GO004_RS17030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_RS17035	COG2010	Cytochrome c
GO004_RS17040	COG2884	Cell division ATP-binding protein ftsE
GO004_RS17045	COG2177	Part of the ABC transporter FtsEX involved in
GO004_RS17050	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS17050	COG0793	Belongs to the peptidase S41A family
GO004_RS17060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_RS17065	COG2814	Major facilitator Superfamily
GO004_RS17070	COG1309	transcriptional regulator
GO004_RS17075	COG0574	Belongs to the PEP-utilizing enzyme family
GO004_RS17075	COG3848	Pyruvate phosphate dikinase
GO004_RS17080	COG4897	Protein conserved in bacteria
GO004_RS17085	COG0556	nucleotide-excision repair
GO004_RS17090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO004_RS17110	COG3595	metallopeptidase activity
GO004_RS17115	COG1983	PspC domain protein
GO004_RS17120	COG1950	PFAM Membrane protein of
GO004_RS17125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO004_RS17130	COG2188	Transcriptional regulator
GO004_RS17135	COG0363	glucosamine-6-phosphate deaminase activity
GO004_RS17140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO004_RS17145	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GO004_RS17150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO004_RS17155	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GO004_RS17160	COG0546	phosphoglycolate phosphatase activity
GO004_RS17165	COG0110	maltose O-acetyltransferase activity
GO004_RS17170	COG5297	Belongs to the glycosyl hydrolase family 6
GO004_RS17175	COG4990	cell redox homeostasis
GO004_RS17180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GO004_RS17185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO004_RS17190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO004_RS17195	COG0131	Imidazoleglycerol-phosphate dehydratase
GO004_RS17200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO004_RS17205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO004_RS17210	COG0107	imidazoleglycerol-phosphate synthase activity
GO004_RS17215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO004_RS17215	COG0140	phosphoribosyl-ATP diphosphatase activity
GO004_RS17235	COG1132	(ABC) transporter
GO004_RS17240	COG0457	Tetratricopeptide repeat
GO004_RS17245	COG0791	NLP P60 protein
GO004_RS17245	COG3883	PFAM NLP P60 protein
GO004_RS17250	COG0492	ferredoxin-NADP+ reductase activity
GO004_RS17255	COG1051	belongs to the nudix hydrolase family
GO004_RS17260	COG1660	Displays ATPase and GTPase activities
GO004_RS17265	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GO004_RS17270	COG1481	regulation of sporulation
GO004_RS17275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS17280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GO004_RS17290	COG0745	RESPONSE REGULATOR receiver
GO004_RS17295	COG5002	protein histidine kinase activity
GO004_RS17300	COG1136	(ABC) transporter
GO004_RS17305	COG0577	efflux transmembrane transporter activity
GO004_RS17310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO004_RS17315	COG0288	reversible hydration of carbon dioxide
GO004_RS17320	COG0659	secondary active sulfate transmembrane transporter activity
GO004_RS17325	COG1694	Mazg nucleotide pyrophosphohydrolase
GO004_RS17330	COG1611	Belongs to the LOG family
GO004_RS17335	COG1609	Transcriptional regulator
GO004_RS17340	COG0366	Alpha amylase catalytic
GO004_RS17345	COG2182	Extracellular solute-binding protein
GO004_RS17350	COG1175	transmembrane transport
GO004_RS17355	COG3833	ABC-type maltose transport systems, permease component
GO004_RS17360	COG5521	maltodextrose utilization protein MalA
GO004_RS17365	COG1554	hydrolase, family 65, central catalytic
GO004_RS17370	COG0366	Alpha amylase catalytic
GO004_RS17375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO004_RS17380	COG0740	serine-type endopeptidase activity
GO004_RS17390	COG3621	Patatin-like phospholipase
GO004_RS17395	COG0277	FAD linked oxidase domain protein
GO004_RS17405	COG2076	Multidrug Resistance protein
GO004_RS17410	COG2076	Multidrug Resistance protein
GO004_RS17415	COG1309	transcriptional regulator
GO004_RS17420	COG0531	amino acid
GO004_RS17425	COG1621	beta-fructofuranosidase activity
GO004_RS17430	COG1621	beta-fructofuranosidase activity
GO004_RS17435	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_RS17440	COG1794	racemase activity, acting on amino acids and derivatives
GO004_RS17450	COG3479	Phenolic acid decarboxylase
GO004_RS17460	COG2272	Belongs to the type-B carboxylesterase lipase family
GO004_RS17465	COG1396	sequence-specific DNA binding
GO004_RS17470	COG3944	biosynthesis protein
GO004_RS17475	COG0489	protein tyrosine kinase activity
GO004_RS17480	COG1086	Polysaccharide biosynthesis protein
GO004_RS17485	COG0438	transferase activity, transferring glycosyl groups
GO004_RS17490	COG1215	transferase activity, transferring glycosyl groups
GO004_RS17495	COG0438	transferase activity, transferring glycosyl groups
GO004_RS17505	COG1216	Glycosyl transferase, family 2
GO004_RS17510	COG5039	Polysaccharide pyruvyl transferase
GO004_RS17515	COG1216	Glycosyl transferase, family 2
GO004_RS17520	COG2244	polysaccharide biosynthetic process
GO004_RS17525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO004_RS17530	COG0110	maltose O-acetyltransferase activity
GO004_RS17535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_RS17540	COG5039	Polysaccharide pyruvyl transferase
GO004_RS17550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO004_RS17555	COG1620	l-lactate permease
GO004_RS17560	COG2186	Transcriptional regulator
GO004_RS17565	COG1609	Transcriptional regulator
GO004_RS17570	COG2182	Extracellular solute-binding protein
GO004_RS17575	COG1175	transmembrane transport
GO004_RS17580	COG3833	ABC-type maltose transport systems, permease component
GO004_RS17585	COG1874	Beta-galactosidase
GO004_RS17590	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GO004_RS17595	COG2208	phosphoserine phosphatase activity
GO004_RS17600	COG0596	Alpha beta hydrolase
GO004_RS17605	COG1131	(ABC) transporter
GO004_RS17610	COG0842	Transport permease protein
GO004_RS17615	COG4585	Histidine kinase
GO004_RS17620	COG2197	response regulator
GO004_RS17625	COG0247	lactate metabolic process
GO004_RS17630	COG1139	Iron-sulfur cluster binding protein
GO004_RS17635	COG1556	Lactate utilization protein
GO004_RS17640	COG3858	chitin binding
GO004_RS17645	COG1113	amino acid transport
GO004_RS17650	COG0697	spore germination
GO004_RS17655	COG0583	DNA-binding transcription factor activity
GO004_RS17660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS17665	COG1609	Transcriptional regulator
GO004_RS17670	COG2814	Major facilitator Superfamily
GO004_RS17675	COG2390	Transcriptional regulator
GO004_RS17680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO004_RS17685	COG0126	phosphoglycerate kinase activity
GO004_RS17690	COG0149	triose-phosphate isomerase activity
GO004_RS17695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO004_RS17700	COG0148	phosphopyruvate hydratase activity
GO004_RS17705	COG0456	acetyltransferase
GO004_RS17710	COG4640	response to antibiotic
GO004_RS17715	COG3064	Membrane
GO004_RS17725	COG2095	MarC family integral membrane protein
GO004_RS17730	COG1510	regulation of RNA biosynthetic process
GO004_RS17735	COG1125	glycine betaine transport
GO004_RS17735	COG0517	IMP dehydrogenase activity
GO004_RS17740	COG1174	glycine betaine transport
GO004_RS17745	COG1732	Glycine betaine
GO004_RS17750	COG1174	glycine betaine transport
GO004_RS17755	COG1510	regulation of RNA biosynthetic process
GO004_RS17760	COG1125	glycine betaine transport
GO004_RS17760	COG0517	IMP dehydrogenase activity
GO004_RS17765	COG1174	glycine betaine transport
GO004_RS17770	COG1732	Glycine betaine
GO004_RS17775	COG1174	glycine betaine transport
GO004_RS17780	COG0840	transmembrane signaling receptor activity
GO004_RS17785	COG1733	regulation of RNA biosynthetic process
GO004_RS17790	COG1396	sequence-specific DNA binding
GO004_RS17795	COG1396	sequence-specific DNA binding
GO004_RS17800	COG1476	TRANSCRIPTIONal
GO004_RS17805	COG0596	Alpha beta hydrolase
GO004_RS17810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO004_RS17815	COG1647	Serine aminopeptidase, S33
GO004_RS17820	COG0557	exoribonuclease II activity
GO004_RS17825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO004_RS17835	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS17840	COG1309	transcriptional regulator
GO004_RS17845	COG2076	Multidrug Resistance protein
GO004_RS17855	COG1289	transmembrane transporter activity
GO004_RS17860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO004_RS17865	COG0673	inositol 2-dehydrogenase activity
GO004_RS17870	COG1937	Protein conserved in bacteria
GO004_RS17875	COG2608	mercury ion transmembrane transporter activity
GO004_RS17880	COG2217	Heavy metal translocating P-type atpase
GO004_RS17885	COG2217	Heavy metal translocating P-type atpase
GO004_RS17890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO004_RS17895	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO004_RS17900	COG2860	membrane
GO004_RS17910	COG3973	AAA domain
GO004_RS17915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_RS17920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_RS17925	COG0025	NhaP-type Na H and K H
GO004_RS17935	COG0656	L-ascorbic acid biosynthetic process
GO004_RS17940	COG4149	molybdate abc transporter
GO004_RS17945	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO004_RS17950	COG1910	domain protein
GO004_RS17955	COG1368	sulfuric ester hydrolase activity
GO004_RS17960	COG1988	membrane-bound metal-dependent
GO004_RS17970	COG0531	amino acid
GO004_RS17975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS17980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS17985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS17990	COG1120	ATPase activity
GO004_RS17995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO004_RS18000	COG1136	(ABC) transporter
GO004_RS18005	COG0577	efflux transmembrane transporter activity
GO004_RS18015	COG2140	Oxalate decarboxylase
GO004_RS18025	COG1191	sigma factor activity
GO004_RS18035	COG0745	RESPONSE REGULATOR receiver
GO004_RS18040	COG2205	protein histidine kinase activity
GO004_RS18045	COG3386	PFAM SMP-30 Gluconolaconase
GO004_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS18055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_RS18060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_RS18065	COG1120	ATPase activity
GO004_RS18070	COG2096	Adenosyltransferase
GO004_RS18075	COG2814	Major facilitator Superfamily
GO004_RS18080	COG4758	membrane
GO004_RS18085	COG1842	Phage shock protein A
GO004_RS18090	COG3595	metallopeptidase activity
GO004_RS18095	COG4758	membrane
GO004_RS18100	COG4585	Histidine kinase
GO004_RS18105	COG2197	response regulator
GO004_RS18115	COG0814	amino acid
GO004_RS18120	COG0697	spore germination
GO004_RS18130	COG0114	fumarate hydratase activity
GO004_RS18135	COG1309	transcriptional regulator
GO004_RS18145	COG2770	Histidine kinase
GO004_RS18145	COG2205	protein histidine kinase activity
GO004_RS18150	COG0745	RESPONSE REGULATOR receiver
GO004_RS18155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_RS18160	COG0783	Belongs to the Dps family
GO004_RS18165	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS18180	COG1120	ATPase activity
GO004_RS18190	COG0583	DNA-binding transcription factor activity
GO004_RS18195	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS18200	COG1942	4-Oxalocrotonate Tautomerase
GO004_RS18205	COG0477	Major facilitator Superfamily
GO004_RS18210	COG1846	Transcriptional regulator
GO004_RS18215	COG5577	PFAM Coat F domain
GO004_RS18225	COG0506	proline dehydrogenase activity
GO004_RS18235	COG1024	Enoyl-CoA hydratase
GO004_RS18235	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO004_RS18240	COG0183	Belongs to the thiolase family
GO004_RS18245	COG1960	acyl-CoA dehydrogenase activity
GO004_RS18250	COG1393	Belongs to the ArsC family
GO004_RS18255	COG0509	glycine decarboxylation via glycine cleavage system
GO004_RS18265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO004_RS18270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS18280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO004_RS18285	COG2011	ABC-type metal ion transport system permease component
GO004_RS18290	COG1464	Belongs to the NlpA lipoprotein family
GO004_RS18295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO004_RS18305	COG0396	ATPase activity
GO004_RS18310	COG0719	Fe-S assembly protein
GO004_RS18315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO004_RS18320	COG0822	iron-sulfur transferase activity
GO004_RS18325	COG0719	Fe-S assembly protein
GO004_RS18340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_RS18345	COG0322	excinuclease ABC activity
GO004_RS18350	COG2222	sugar isomerase
GO004_RS18355	COG1653	transport
GO004_RS18360	COG1175	transmembrane transport
GO004_RS18365	COG0395	ABC-type sugar transport system, permease component
GO004_RS18370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_RS18375	COG2188	Transcriptional regulator
GO004_RS18380	COG3842	ATPase activity
GO004_RS18385	COG2356	endonuclease I
GO004_RS18395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_RS18400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO004_RS18405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GO004_RS18410	COG2068	MobA-Related Protein
GO004_RS18415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GO004_RS18420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO004_RS18425	COG2080	2 iron, 2 sulfur cluster binding
GO004_RS18435	COG2351	hydroxyisourate hydrolase activity
GO004_RS18440	COG3648	Uricase
GO004_RS18440	COG3195	allantoin biosynthetic process
GO004_RS18445	COG2233	PERMEase
GO004_RS18450	COG2233	PERMEase
GO004_RS18455	COG2508	Transcriptional regulator
GO004_RS18460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO004_RS18470	COG1801	Protein of unknown function DUF72
GO004_RS18475	COG0730	response to heat
GO004_RS18480	COG0737	Belongs to the 5'-nucleotidase family
GO004_RS18485	COG3377	Domain of unknown function (DUF1805)
GO004_RS18495	COG0739	heme binding
GO004_RS18500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO004_RS18510	COG4470	Protein conserved in bacteria
GO004_RS18515	COG2445	Protein of unknown function DUF86
GO004_RS18520	COG0647	UMP catabolic process
GO004_RS18525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO004_RS18530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_RS18535	COG0460	homoserine dehydrogenase
GO004_RS18540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO004_RS18545	COG0083	homoserine kinase activity
GO004_RS18550	COG1506	peptidase
GO004_RS18550	COG0823	Involved in the tonB-independent uptake of proteins
GO004_RS18550	COG4946	Tricorn protease homolog
GO004_RS18555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO004_RS18560	COG4837	Protein of unknown function (DUF1462)
GO004_RS18565	COG1252	NADH dehydrogenase
GO004_RS18570	COG4844	belongs to the
GO004_RS18575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_RS18580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO004_RS18585	COG0316	Belongs to the HesB IscA family
GO004_RS18590	COG0456	acetyltransferase
GO004_RS18595	COG2808	Putative FMN-binding domain
GO004_RS18600	COG0516	GMP reductase activity
GO004_RS18610	COG0492	ferredoxin-NADP+ reductase activity
GO004_RS18615	COG1252	NADH dehydrogenase
GO004_RS18630	COG3584	3D domain protein
GO004_RS18635	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GO004_RS18640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO004_RS18645	COG2056	Na+-H+ antiporter family
GO004_RS18650	COG1268	BioY protein
GO004_RS18655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO004_RS18660	COG2819	hydrolase of the alpha beta superfamily
GO004_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS18670	COG1169	isochorismate synthase
GO004_RS18675	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO004_RS18680	COG3433	isochorismatase activity
GO004_RS18680	COG1535	isochorismatase
GO004_RS18685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_RS18690	COG3251	PFAM MbtH domain protein
GO004_RS18695	COG5634	Uncharacterized conserved protein (DUF2278)
GO004_RS18700	COG0686	Belongs to the AlaDH PNT family
GO004_RS18705	COG2508	Transcriptional regulator
GO004_RS18705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO004_RS18710	COG4842	Belongs to the WXG100 family
GO004_RS18715	COG5417	Belongs to the EsaB family
GO004_RS18720	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO004_RS18725	COG0433	COG0433 Predicted ATPase
GO004_RS18725	COG1674	ftsk spoiiie
GO004_RS18730	COG1511	domain protein
GO004_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS18745	COG1418	mRNA catabolic process
GO004_RS18760	COG0628	permease
GO004_RS18775	COG5506	Protein of unknown function (DUF1694)
GO004_RS18780	COG1335	isochorismatase
GO004_RS18785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO004_RS18790	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO004_RS18810	COG0142	geranyltranstransferase activity
GO004_RS18820	COG4585	Histidine kinase
GO004_RS18825	COG2197	response regulator
GO004_RS18830	COG2050	protein possibly involved in aromatic compounds catabolism
GO004_RS18835	COG1320	monovalent cation:proton antiporter activity
GO004_RS18840	COG2212	antiporter activity
GO004_RS18845	COG1863	multisubunit Na H antiporter MnhE subunit
GO004_RS18850	COG0651	ATP synthesis coupled electron transport
GO004_RS18855	COG1006	Multisubunit Na H antiporter MnhC subunit
GO004_RS18860	COG2111	Na H antiporter
GO004_RS18865	COG2111	Na H antiporter
GO004_RS18865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO004_RS18875	COG3493	citrate carrier protein
GO004_RS18880	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO004_RS18885	COG4603	Belongs to the binding-protein-dependent transport system permease family
GO004_RS18890	COG3845	ABC transporter
GO004_RS18895	COG1744	ABC transporter substrate-binding protein PnrA-like
GO004_RS18900	COG4565	transcriptional regulatory protein
GO004_RS18905	COG3290	protein histidine kinase activity
GO004_RS18915	COG3011	Protein conserved in bacteria
GO004_RS18920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_RS18925	COG2814	Major facilitator Superfamily
GO004_RS18930	COG5018	Exonuclease
GO004_RS18940	COG2205	protein histidine kinase activity
GO004_RS18945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO004_RS18955	COG2267	carboxylic ester hydrolase activity
GO004_RS18960	COG1522	sequence-specific DNA binding
GO004_RS18965	COG0436	Aminotransferase
GO004_RS18970	COG1098	S1 RNA binding domain
GO004_RS18975	COG2155	Conserved Protein
GO004_RS18980	COG1979	alcohol dehydrogenase
GO004_RS18985	COG1979	alcohol dehydrogenase
GO004_RS18990	COG0166	Belongs to the GPI family
GO004_RS19005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO004_RS19020	COG2738	Putative neutral zinc metallopeptidase
GO004_RS19025	COG1253	flavin adenine dinucleotide binding
GO004_RS19030	COG0366	Alpha amylase catalytic
GO004_RS19040	COG0432	Pfam Uncharacterised protein family UPF0047
GO004_RS19055	COG0840	transmembrane signaling receptor activity
GO004_RS19060	COG0840	transmembrane signaling receptor activity
GO004_RS19065	COG0840	transmembrane signaling receptor activity
GO004_RS19070	COG0840	transmembrane signaling receptor activity
GO004_RS19075	COG3347	Dehydrogenase
GO004_RS19075	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS19080	COG1349	DNA-binding transcription factor activity
GO004_RS19085	COG1070	Carbohydrate kinase
GO004_RS19090	COG3254	rhamnose metabolic process
GO004_RS19095	COG4806	L-rhamnose isomerase
GO004_RS19100	COG0673	inositol 2-dehydrogenase activity
GO004_RS19105	COG0628	permease
GO004_RS19110	COG1968	undecaprenyl-diphosphatase activity
GO004_RS19120	COG5553	Cysteine dioxygenase type I
GO004_RS19125	COG0477	Major facilitator Superfamily
GO004_RS19130	COG1705	Flagellar rod assembly protein muramidase FlgJ
GO004_RS19135	COG4682	membrane
GO004_RS19140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO004_RS19145	COG0569	domain protein
GO004_RS19155	COG1510	regulation of RNA biosynthetic process
GO004_RS19160	COG1012	belongs to the aldehyde dehydrogenase family
GO004_RS19165	COG1454	alcohol dehydrogenase
GO004_RS19175	COG2318	DinB family
GO004_RS19180	COG1585	Membrane protein implicated in regulation of membrane protease activity
GO004_RS19185	COG2268	Band 7 protein
GO004_RS19190	COG1247	-acetyltransferase
GO004_RS19195	COG3859	Proton-coupled thiamine transporter YuaJ
GO004_RS19320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO004_RS19325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO004_RS19330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO004_RS19335	COG0297	glycogen (starch) synthase activity
GO004_RS19340	COG0058	SHG alpha-glucan phosphorylase activity
GO004_RS19345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GO004_RS19350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_RS19355	COG0438	transferase activity, transferring glycosyl groups
GO004_RS19360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_RS19370	COG0438	transferase activity, transferring glycosyl groups
GO004_RS19375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_RS19380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_RS19385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_RS19390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_RS19395	COG1169	isochorismate synthase
GO004_RS19400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO004_RS19405	COG0596	Alpha beta hydrolase
GO004_RS19410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO004_RS19415	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS19420	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_RS19425	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO004_RS19430	COG1121	(ABC) transporter
GO004_RS19435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_RS19435	COG1321	iron dependent repressor
GO004_RS19440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_RS19450	COG1294	oxidase, subunit
GO004_RS19455	COG1271	oxidase subunit
GO004_RS19460	COG0254	rRNA binding
GO004_RS19465	COG0288	reversible hydration of carbon dioxide
GO004_RS19470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO004_RS19475	COG1854	S-ribosylhomocysteine lyase activity
GO004_RS19490	COG0783	Belongs to the Dps family
GO004_RS19495	COG4824	toxin secretion phage lysis holin
GO004_RS19500	COG0494	nUDIX hydrolase
GO004_RS19505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO004_RS19510	COG1116	anion transmembrane transporter activity
GO004_RS19515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO004_RS19520	COG1506	peptidase
GO004_RS19530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO004_RS19535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GO004_RS19540	COG0367	asparagine synthase
GO004_RS19545	COG1113	amino acid transport
GO004_RS19550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO004_RS19555	COG2267	carboxylic ester hydrolase activity
GO004_RS19565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GO004_RS19570	COG1242	4 iron, 4 sulfur cluster binding
GO004_RS19585	COG1725	Transcriptional regulator
GO004_RS19590	COG1131	(ABC) transporter
GO004_RS19605	COG1136	(ABC) transporter
GO004_RS19610	COG0577	efflux transmembrane transporter activity
GO004_RS19615	COG0745	RESPONSE REGULATOR receiver
GO004_RS19620	COG2205	protein histidine kinase activity
GO004_RS19625	COG1136	(ABC) transporter
GO004_RS19630	COG0577	efflux transmembrane transporter activity
GO004_RS19635	COG2433	Pfam Transposase IS66
GO004_RS19640	COG2814	Major facilitator Superfamily
GO004_RS19645	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_RS19645	COG2202	Pas domain
GO004_RS19655	COG0495	leucyl-tRNA aminoacylation
GO004_RS19660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_RS19665	COG1486	melibiose metabolic process
GO004_RS19670	COG0395	ABC-type sugar transport system, permease component
GO004_RS19675	COG1175	transmembrane transport
GO004_RS19680	COG1653	transport
GO004_RS19685	COG1609	Transcriptional regulator
GO004_RS19690	COG1073	alpha beta
GO004_RS19700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_RS19705	COG0156	8-amino-7-oxononanoate synthase activity
GO004_RS19715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO004_RS19720	COG2124	cytochrome p450
GO004_RS19725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_RS19730	COG0395	ABC-type sugar transport system, permease component
GO004_RS19735	COG1653	transport
GO004_RS19740	COG2207	Transcriptional regulator
GO004_RS19745	COG4209	transmembrane transport
GO004_RS19750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO004_RS19755	COG1653	transport
GO004_RS19760	COG0673	inositol 2-dehydrogenase activity
GO004_RS19765	COG5578	integral membrane protein
GO004_RS19775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO004_RS19780	COG2081	HI0933 family
GO004_RS19785	COG2244	polysaccharide biosynthetic process
GO004_RS19790	COG1187	pseudouridine synthase activity
GO004_RS19795	COG1349	DNA-binding transcription factor activity
GO004_RS19800	COG1131	(ABC) transporter
GO004_RS19805	COG4473	ABC transporter
GO004_RS19810	COG2252	PERMEase
GO004_RS19815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_RS19820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_RS19825	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO004_RS19835	COG1597	lipid kinase activity
GO004_RS19840	COG1523	belongs to the glycosyl hydrolase 13 family
GO004_RS19845	COG0510	thiamine kinase activity
GO004_RS19855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO004_RS19860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_RS19865	COG0281	malic enzyme
GO004_RS19870	COG5584	Small secreted protein
GO004_RS19875	COG1363	Peptidase, m42
GO004_RS19890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_RS19895	COG4848	Belongs to the UPF0354 family
GO004_RS19900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_RS19905	COG1674	ftsk spoiiie
GO004_RS19910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO004_RS19915	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO004_RS19920	COG4980	gas vesicle protein
GO004_RS19925	COG3118	belongs to the thioredoxin family
GO004_RS19930	COG1605	Chorismate mutase
GO004_RS19930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GO004_RS19935	COG1609	Transcriptional regulator
GO004_RS19940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO004_RS19945	COG1360	Flagellar Motor Protein
GO004_RS19950	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO004_RS19955	COG0517	IMP dehydrogenase activity
GO004_RS19960	COG0454	-acetyltransferase
GO004_RS19965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO004_RS19970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO004_RS19975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO004_RS19980	COG2203	Gaf domain
GO004_RS19980	COG2199	diguanylate cyclase activity
GO004_RS19985	COG1956	GAF domain-containing protein
GO004_RS19990	COG1309	transcriptional regulator
GO004_RS19995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO004_RS20000	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GO004_RS20005	COG1114	Component of the transport system for branched-chain amino acids
GO004_RS20010	COG1104	cysteine desulfurase activity
GO004_RS20015	COG0301	tRNA thio-modification
GO004_RS20025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO004_RS20030	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GO004_RS20035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO004_RS20040	COG0616	signal peptide processing
GO004_RS20045	COG1714	RDD family
GO004_RS20055	COG3874	Sporulation protein YtfJ
GO004_RS20060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GO004_RS20065	COG0827	DNA restriction-modification system
GO004_RS20075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO004_RS20080	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO004_RS20085	COG0137	argininosuccinate synthase activity
GO004_RS20090	COG0165	Argininosuccinate lyase
GO004_RS20095	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_RS20100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GO004_RS20105	COG0583	DNA-binding transcription factor activity
GO004_RS20110	COG0454	-acetyltransferase
GO004_RS20115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS20120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS20125	COG0765	amino acid transport
GO004_RS20130	COG0765	amino acid transport
GO004_RS20135	COG1126	abc transporter atp-binding protein
GO004_RS20140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS20145	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO004_RS20150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_RS20160	COG1473	amidohydrolase
GO004_RS20165	COG0730	response to heat
GO004_RS20170	COG4109	DRTGG domain
GO004_RS20180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GO004_RS20200	COG0587	DNA-directed DNA polymerase activity
GO004_RS20205	COG0281	malic enzyme
GO004_RS20210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO004_RS20215	COG0825	malonyl-CoA metabolic process
GO004_RS20220	COG0205	6-phosphofructokinase activity
GO004_RS20225	COG0469	pyruvate kinase activity
GO004_RS20230	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO004_RS20235	COG0628	permease
GO004_RS20240	COG2707	UPF0756 membrane protein
GO004_RS20245	COG0372	Belongs to the citrate synthase family
GO004_RS20250	COG0538	isocitrate dehydrogenase activity
GO004_RS20255	COG0039	L-malate dehydrogenase activity
GO004_RS20260	COG0745	RESPONSE REGULATOR receiver
GO004_RS20265	COG5002	protein histidine kinase activity
GO004_RS20270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_RS20270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_RS20275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO004_RS20280	COG1971	Probably functions as a manganese efflux pump
GO004_RS20285	COG0237	dephospho-CoA kinase activity
GO004_RS20290	COG0656	L-ascorbic acid biosynthetic process
GO004_RS20295	COG2814	Major facilitator Superfamily
GO004_RS20300	COG1733	regulation of RNA biosynthetic process
GO004_RS20305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO004_RS20310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GO004_RS20315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO004_RS20320	COG3611	Membrane attachment protein
GO004_RS20325	COG1484	DNA-dependent DNA replication
GO004_RS20330	COG0398	Pfam SNARE associated Golgi protein
GO004_RS20340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO004_RS20345	COG1011	Hydrolase
GO004_RS20350	COG3275	phosphorelay sensor kinase activity
GO004_RS20355	COG3279	Response regulator of the LytR AlgR family
GO004_RS20360	COG1380	Effector of murein hydrolase LrgA
GO004_RS20365	COG1346	cytolysis
GO004_RS20375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO004_RS20380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO004_RS20385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO004_RS20390	COG3326	Membrane
GO004_RS20400	COG1363	Peptidase, m42
GO004_RS20405	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_RS20410	COG2160	L-arabinose isomerase activity
GO004_RS20415	COG1069	ribulokinase activity
GO004_RS20420	COG0235	Class ii aldolase
GO004_RS20425	COG0647	UMP catabolic process
GO004_RS20430	COG0371	Dehydrogenase
GO004_RS20435	COG1653	transport
GO004_RS20440	COG1175	transmembrane transport
GO004_RS20445	COG0395	ABC-type sugar transport system, permease component
GO004_RS20450	COG3534	alpha-L-arabinofuranosidase
GO004_RS20455	COG1966	Carbon starvation protein
GO004_RS20465	COG0247	lactate metabolic process
GO004_RS20470	COG0277	FAD linked oxidase domain protein
GO004_RS20475	COG3835	regulator
GO004_RS20485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO004_RS20495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO004_RS20500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_RS20500	COG0072	phenylalanine-tRNA ligase activity
GO004_RS20505	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO004_RS20510	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO004_RS20515	COG1286	toxin biosynthetic process
GO004_RS20520	COG1796	DNA polymerase
GO004_RS20520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO004_RS20525	COG1193	negative regulation of DNA recombination
GO004_RS20530	COG3766	membrane
GO004_RS20535	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_RS20540	COG1309	transcriptional regulator
GO004_RS20545	COG1024	Enoyl-CoA hydratase
GO004_RS20550	COG2086	electron transfer activity
GO004_RS20555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO004_RS20560	COG3534	alpha-L-arabinofuranosidase
GO004_RS20565	COG3118	belongs to the thioredoxin family
GO004_RS20570	COG0322	excinuclease ABC activity
GO004_RS20575	COG0527	aspartate kinase activity
GO004_RS20580	COG1719	4-vinyl reductase, 4VR
GO004_RS20585	COG2009	succinate dehydrogenase
GO004_RS20590	COG1053	succinate dehydrogenase
GO004_RS20595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO004_RS20600	COG0824	Thioesterase
GO004_RS20605	COG2197	response regulator
GO004_RS20610	COG1846	Transcriptional regulator
GO004_RS20615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO004_RS20620	COG5401	PFAM Sporulation and spore germination
GO004_RS20625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO004_RS20630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO004_RS20635	COG0622	Phosphoesterase
GO004_RS20645	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GO004_RS20650	COG0454	-acetyltransferase
GO004_RS20660	COG0028	Belongs to the TPP enzyme family
GO004_RS20665	COG0440	acetolactate synthase activity
GO004_RS20670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO004_RS20675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO004_RS20680	COG0473	3-isopropylmalate dehydrogenase activity
GO004_RS20685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO004_RS20690	COG0066	3-isopropylmalate dehydratase activity
GO004_RS20695	COG1477	protein flavinylation
GO004_RS20695	COG0457	Tetratricopeptide repeat
GO004_RS20700	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO004_RS20705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO004_RS20710	COG0470	DNA polymerase III
GO004_RS20710	COG1067	ATP-dependent peptidase activity
GO004_RS20715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO004_RS20720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO004_RS20730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO004_RS20735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO004_RS20740	COG0181	hydroxymethylbilane synthase activity
GO004_RS20745	COG1587	Uroporphyrinogen-III synthase
GO004_RS20750	COG0113	porphobilinogen synthase activity
GO004_RS20755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO004_RS20760	COG1388	LysM domain
GO004_RS20765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_RS20775	COG0525	valine-tRNA ligase activity
GO004_RS20780	COG0285	dihydrofolate synthase activity
GO004_RS20785	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GO004_RS20795	COG0424	maF-like protein
GO004_RS20800	COG2003	Belongs to the UPF0758 family
GO004_RS20815	COG1396	sequence-specific DNA binding
GO004_RS20985	COG5412	phage tail tape measure protein
GO004_RS20985	COG3953	SLT domain
GO004_RS21000	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_RS21025	COG4824	toxin secretion phage lysis holin
GO004_RS21030	COG1388	LysM domain
GO004_RS21030	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_RS21030	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS21060	COG1077	Cell shape determining protein MreB Mrl
GO004_RS21070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO004_RS21075	COG0850	regulation of cytokinetic process
GO004_RS21080	COG2894	cell division
GO004_RS21085	COG0739	heme binding
GO004_RS21090	COG1994	Peptidase M50
GO004_RS21095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO004_RS21100	COG2868	ribosomal protein
GO004_RS21105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO004_RS21115	COG3290	protein histidine kinase activity
GO004_RS21120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO004_RS21125	COG4492	Belongs to the UPF0735 family
GO004_RS21130	COG0077	Prephenate dehydratase
GO004_RS21135	COG1827	regulation of RNA biosynthetic process
GO004_RS21140	COG1104	cysteine desulfurase activity
GO004_RS21145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GO004_RS21150	COG0157	Belongs to the NadC ModD family
GO004_RS21155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO004_RS21160	COG1388	LysM domain
GO004_RS21170	COG0217	transcriptional regulatory protein
GO004_RS21175	COG1115	amino acid carrier protein
GO004_RS21195	COG2112	serine threonine protein kinase
GO004_RS21200	COG0673	inositol 2-dehydrogenase activity
GO004_RS21205	COG2814	Major facilitator Superfamily
GO004_RS21215	COG0632	four-way junction helicase activity
GO004_RS21220	COG2255	four-way junction helicase activity
GO004_RS21230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO004_RS21235	COG0343	queuine tRNA-ribosyltransferase activity
GO004_RS21240	COG1862	Preprotein translocase
GO004_RS21250	COG2323	membrane
GO004_RS21255	COG2244	polysaccharide biosynthetic process
GO004_RS21265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO004_RS21265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO004_RS21270	COG0490	domain, Protein
GO004_RS21275	COG5416	Lipopolysaccharide assembly protein A domain
GO004_RS21280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO004_RS21280	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GO004_RS21285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_RS21290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO004_RS21295	COG1490	D-aminoacyl-tRNA deacylase activity
GO004_RS21300	COG4991	sh3 domain protein
GO004_RS21300	COG3103	Sh3 type 3 domain protein
GO004_RS21300	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_RS21310	COG0124	histidyl-tRNA synthetase
GO004_RS21315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO004_RS21325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO004_RS21330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO004_RS21335	COG1959	2 iron, 2 sulfur cluster binding
GO004_RS21340	COG1104	cysteine desulfurase activity
GO004_RS21345	COG0482	sulfurtransferase activity
GO004_RS21350	COG0457	Tetratricopeptide repeat
GO004_RS21355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO004_RS21360	COG3881	PFAM PRC-barrel domain
GO004_RS21375	COG0765	amino acid transport
GO004_RS21380	COG0765	amino acid transport
GO004_RS21385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_RS21390	COG1126	abc transporter atp-binding protein
GO004_RS21395	COG0628	permease
GO004_RS21400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO004_RS21405	COG4472	Bacterial protein of unknown function (DUF965)
GO004_RS21410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO004_RS21415	COG3906	Belongs to the UPF0473 family
GO004_RS21420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO004_RS21425	COG4122	O-methyltransferase activity
GO004_RS21430	COG0826	peptidase U32
GO004_RS21435	COG0826	peptidase U32
GO004_RS21440	COG0572	uridine kinase
GO004_RS21445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO004_RS21450	COG0768	penicillin binding
GO004_RS21465	COG2226	methyltransferase
GO004_RS21470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO004_RS21475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_RS21480	COG0626	cystathionine gamma-synthase activity
GO004_RS21490	COG2427	Protein of unknown function (DUF1641)
GO004_RS21495	COG3383	formate dehydrogenase (NAD+) activity
GO004_RS21500	COG5609	conserved protein (DUF2294)
GO004_RS21505	COG2116	formate transmembrane transporter activity
GO004_RS21520	COG2226	methyltransferase
GO004_RS21525	COG1309	transcriptional regulator
GO004_RS21530	COG2124	cytochrome p450
GO004_RS21530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_RS21540	COG2755	lipolytic protein G-D-S-L family
GO004_RS21540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GO004_RS21550	COG1595	DNA-templated transcription, initiation
GO004_RS21555	COG1378	Sugar-specific transcriptional regulator TrmB
GO004_RS21560	COG1280	lysine exporter protein (LysE YggA)
GO004_RS21565	COG1113	amino acid transport
GO004_RS21575	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GO004_RS21575	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO004_RS21580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_RS21585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_RS21590	COG3715	PTS system
GO004_RS21595	COG3716	PTS system mannose fructose sorbose family IID component
GO004_RS21600	COG1621	beta-fructofuranosidase activity
GO004_RS21605	COG0693	protein deglycase activity
GO004_RS21610	COG1064	alcohol dehydrogenase
GO004_RS21620	COG0789	Transcriptional regulator
GO004_RS21625	COG5577	PFAM Coat F domain
GO004_RS21635	COG1063	alcohol dehydrogenase
GO004_RS21640	COG5577	PFAM Coat F domain
GO004_RS21650	COG0346	lactoylglutathione lyase activity
GO004_RS21660	COG4991	sh3 domain protein
GO004_RS21665	COG4991	sh3 domain protein
GO004_RS21670	COG0596	Alpha beta hydrolase
GO004_RS21675	COG5566	PFAM Mor transcription activator
GO004_RS21680	COG3409	Peptidoglycan-binding domain 1 protein
GO004_RS21685	COG2828	Protein conserved in bacteria
GO004_RS21690	COG0583	DNA-binding transcription factor activity
GO004_RS21695	COG2851	Citrate transporter
GO004_RS21700	COG0667	Aldo Keto reductase
GO004_RS21705	COG1595	DNA-templated transcription, initiation
GO004_RS21710	COG3443	Belongs to the bacterial solute-binding protein 9 family
GO004_RS21720	COG2315	Protein conserved in bacteria