locus-tag	class	description
ITP52_RS00010	COG0463	Glycosyl transferase, family 2
ITP52_RS00015	COG0456	acetyltransferase
ITP52_RS00030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITP52_RS00035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ITP52_RS00040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ITP52_RS00045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITP52_RS00050	COG0456	acetyltransferase
ITP52_RS00055	COG1509	lysine 2,3-aminomutase activity
ITP52_RS00065	COG4479	Belongs to the UPF0346 family
ITP52_RS00085	COG0671	phosphoesterase, PA-phosphatase related
ITP52_RS00100	COG0813	purine-nucleoside phosphorylase activity
ITP52_RS00105	COG1876	peptidase activity
ITP52_RS00115	COG2226	methyltransferase
ITP52_RS00120	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS00120	COG0793	Belongs to the peptidase S41A family
ITP52_RS00125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITP52_RS00135	COG0346	lactoylglutathione lyase activity
ITP52_RS00140	COG0400	carboxylic ester hydrolase activity
ITP52_RS00145	COG0778	Nitroreductase
ITP52_RS00150	COG1733	regulation of RNA biosynthetic process
ITP52_RS00155	COG1942	4-Oxalocrotonate Tautomerase
ITP52_RS00160	COG2610	gluconate transmembrane transporter activity
ITP52_RS00175	COG2962	Rard protein
ITP52_RS00185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ITP52_RS00190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ITP52_RS00195	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS00200	COG0534	Mate efflux family protein
ITP52_RS00205	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ITP52_RS00210	COG1819	glycosyl
ITP52_RS00215	COG1388	LysM domain
ITP52_RS00215	COG0791	NLP P60 protein
ITP52_RS00220	COG2032	superoxide dismutase activity
ITP52_RS00225	COG0714	Associated with various cellular activities
ITP52_RS00230	COG4548	von Willebrand factor, type A
ITP52_RS00235	COG0567	Dehydrogenase, E1 component
ITP52_RS00240	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITP52_RS00245	COG0385	Bile acid
ITP52_RS00250	COG0733	neurotransmitter:sodium symporter activity
ITP52_RS00255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ITP52_RS00260	COG1657	PFAM Prenyltransferase squalene oxidase
ITP52_RS00265	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS00290	COG0071	Belongs to the small heat shock protein (HSP20) family
ITP52_RS00305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITP52_RS00310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ITP52_RS00320	COG0514	ATP-dependent DNA helicase (RecQ)
ITP52_RS00325	COG3584	3D domain protein
ITP52_RS00325	COG1388	LysM domain
ITP52_RS00330	COG2197	response regulator
ITP52_RS00335	COG4585	Histidine kinase
ITP52_RS00340	COG3239	Fatty acid desaturase
ITP52_RS00345	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITP52_RS00360	COG2322	membrane
ITP52_RS00365	COG0741	lytic transglycosylase activity
ITP52_RS00370	COG0640	Transcriptional regulator
ITP52_RS00380	COG2378	regulation of single-species biofilm formation
ITP52_RS00385	COG3708	Transcriptional regulator
ITP52_RS00390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS00395	COG1309	transcriptional regulator
ITP52_RS00400	COG0456	acetyltransferase
ITP52_RS00405	COG2207	Transcriptional regulator
ITP52_RS00405	COG0662	Cupin 2, conserved barrel domain protein
ITP52_RS00410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITP52_RS00415	COG1231	oxidoreductase activity
ITP52_RS00420	COG4282	regulation of fungal-type cell wall biogenesis
ITP52_RS00430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITP52_RS00440	COG0457	Tetratricopeptide repeat
ITP52_RS00470	COG3655	Transcriptional regulator
ITP52_RS00500	COG2314	TM2 domain
ITP52_RS00505	COG0726	polysaccharide deacetylase
ITP52_RS00510	COG0574	Belongs to the PEP-utilizing enzyme family
ITP52_RS00510	COG3848	Pyruvate phosphate dikinase
ITP52_RS00525	COG2367	Beta-lactamase
ITP52_RS00530	COG0693	protein deglycase activity
ITP52_RS00540	COG0697	spore germination
ITP52_RS00545	COG0583	DNA-binding transcription factor activity
ITP52_RS00550	COG3739	integral membrane protein
ITP52_RS00565	COG2720	vancomycin resistance protein
ITP52_RS00590	COG2140	Oxalate decarboxylase
ITP52_RS00600	COG2135	peptidase activity
ITP52_RS00605	COG3866	Pectate lyase
ITP52_RS00610	COG3619	membrane
ITP52_RS00615	COG4305	rare lipoprotein A
ITP52_RS00620	COG2368	4-hydroxyphenylacetate
ITP52_RS00625	COG0840	transmembrane signaling receptor activity
ITP52_RS00625	COG5278	phosphoserine phosphatase activity
ITP52_RS00645	COG1609	Transcriptional regulator
ITP52_RS00650	COG1082	Xylose isomerase domain protein TIM barrel
ITP52_RS00655	COG0673	inositol 2-dehydrogenase activity
ITP52_RS00660	COG2814	Major facilitator Superfamily
ITP52_RS00670	COG0243	molybdopterin cofactor binding
ITP52_RS00675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITP52_RS00680	COG1070	Carbohydrate kinase
ITP52_RS00685	COG2814	Major facilitator Superfamily
ITP52_RS00695	COG1131	(ABC) transporter
ITP52_RS00710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS00720	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ITP52_RS00725	COG0300	oxidoreductase activity
ITP52_RS00735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITP52_RS00740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ITP52_RS00745	COG0583	DNA-binding transcription factor activity
ITP52_RS00750	COG0067	glutamate synthase
ITP52_RS00750	COG0069	glutamate synthase activity
ITP52_RS00750	COG0070	glutamate synthase
ITP52_RS00755	COG0493	'glutamate synthase
ITP52_RS00765	COG0583	DNA-binding transcription factor activity
ITP52_RS00770	COG0405	Gamma-glutamyltransferase
ITP52_RS00775	COG0166	Belongs to the GPI family
ITP52_RS00780	COG0582	viral genome integration into host DNA
ITP52_RS00795	COG0534	Mate efflux family protein
ITP52_RS00800	COG2017	converts alpha-aldose to the beta-anomer
ITP52_RS00805	COG2027	D-alanyl-D-alanine carboxypeptidase
ITP52_RS00810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS00815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS00820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS00825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS00830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS00830	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ITP52_RS00840	COG1649	PFAM Uncharacterised BCR, COG1649
ITP52_RS00850	COG1960	acyl-CoA dehydrogenase activity
ITP52_RS00855	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS00860	COG0439	Biotin carboxylase
ITP52_RS00865	COG0511	ligase activity, forming carbon-carbon bonds
ITP52_RS00870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITP52_RS00875	COG1024	Enoyl-CoA hydratase
ITP52_RS00880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ITP52_RS00885	COG2404	hydrolase activity, acting on ester bonds
ITP52_RS00890	COG0586	Pfam SNARE associated Golgi protein
ITP52_RS00895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ITP52_RS00900	COG2246	polysaccharide biosynthetic process
ITP52_RS00905	COG3507	Belongs to the glycosyl hydrolase 43 family
ITP52_RS00910	COG5520	Belongs to the glycosyl hydrolase 30 family
ITP52_RS00920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ITP52_RS00925	COG1115	amino acid carrier protein
ITP52_RS00935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ITP52_RS00940	COG0187	DNA topoisomerase II activity
ITP52_RS00945	COG1832	CoA-binding protein
ITP52_RS00950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ITP52_RS00955	COG4841	protein insertion into membrane
ITP52_RS00965	COG0824	Thioesterase
ITP52_RS00985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS00990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ITP52_RS01005	COG0071	Belongs to the small heat shock protein (HSP20) family
ITP52_RS01015	COG4846	Membrane protein involved in cytochrome C biogenesis
ITP52_RS01020	COG2201	protein-glutamate methylesterase activity
ITP52_RS01025	COG0785	Cytochrome C biogenesis protein
ITP52_RS01035	COG3763	UPF0154 protein
ITP52_RS01045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITP52_RS01050	COG4224	UPF0291 protein
ITP52_RS01055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ITP52_RS01060	COG1388	LysM domain
ITP52_RS01065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ITP52_RS01070	COG0346	lactoylglutathione lyase activity
ITP52_RS01080	COG4195	phage-related replication protein
ITP52_RS01110	COG0531	amino acid
ITP52_RS01115	COG0697	spore germination
ITP52_RS01130	COG3832	glyoxalase III activity
ITP52_RS01145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITP52_RS01185	COG0756	dUTP diphosphatase activity
ITP52_RS01200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITP52_RS01205	COG2814	Major facilitator Superfamily
ITP52_RS01220	COG1070	Carbohydrate kinase
ITP52_RS01225	COG2115	Belongs to the xylose isomerase family
ITP52_RS01230	COG1940	carbohydrate kinase activity
ITP52_RS01235	COG3507	Belongs to the glycosyl hydrolase 43 family
ITP52_RS01245	COG0135	phosphoribosylanthranilate isomerase activity
ITP52_RS01275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS01285	COG4282	regulation of fungal-type cell wall biogenesis
ITP52_RS01310	COG0174	glutamine synthetase
ITP52_RS01315	COG0789	Transcriptional regulator
ITP52_RS01320	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ITP52_RS01325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ITP52_RS01330	COG0464	growth
ITP52_RS01335	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS01340	COG4112	unkown
ITP52_RS01345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS01350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS01355	COG1780	Probably involved in ribonucleotide reductase function
ITP52_RS01370	COG1923	regulation of RNA biosynthetic process
ITP52_RS01375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ITP52_RS01390	COG2076	Multidrug Resistance protein
ITP52_RS01395	COG2076	Multidrug Resistance protein
ITP52_RS01400	COG1764	response to oxidative stress
ITP52_RS01415	COG1404	Belongs to the peptidase S8 family
ITP52_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS01430	COG2124	cytochrome p450
ITP52_RS01435	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ITP52_RS01435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ITP52_RS01435	COG3321	synthase
ITP52_RS01435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITP52_RS01440	COG3321	synthase
ITP52_RS01440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS01440	COG4221	oxidoreductase activity
ITP52_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS01445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS01445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITP52_RS01445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITP52_RS01445	COG3321	synthase
ITP52_RS01445	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS01450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITP52_RS01450	COG3321	synthase
ITP52_RS01450	COG4221	oxidoreductase activity
ITP52_RS01450	COG0300	oxidoreductase activity
ITP52_RS01455	COG3321	synthase
ITP52_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS01455	COG0300	oxidoreductase activity
ITP52_RS01455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS01455	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS01460	COG1024	Enoyl-CoA hydratase
ITP52_RS01465	COG1024	Enoyl-CoA hydratase
ITP52_RS01470	COG3425	synthase
ITP52_RS01475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITP52_RS01480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITP52_RS01485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITP52_RS01485	COG2070	2-Nitropropane dioxygenase
ITP52_RS01490	COG3321	synthase
ITP52_RS01500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITP52_RS01510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS01515	COG3226	Transcriptional regulator
ITP52_RS01530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ITP52_RS01545	COG4550	Control of competence regulator ComK, YlbF/YmcA
ITP52_RS01550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ITP52_RS01555	COG0156	8-amino-7-oxononanoate synthase activity
ITP52_RS01560	COG1063	alcohol dehydrogenase
ITP52_RS01565	COG2359	stage V sporulation protein S
ITP52_RS01570	COG1692	metallophosphoesterase
ITP52_RS01575	COG1418	mRNA catabolic process
ITP52_RS01580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ITP52_RS01585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ITP52_RS01590	COG1058	Belongs to the CinA family
ITP52_RS01590	COG1546	Belongs to the CinA family
ITP52_RS01595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ITP52_RS01600	COG1426	Protein conserved in bacteria
ITP52_RS01615	COG0300	oxidoreductase activity
ITP52_RS01620	COG0612	Peptidase, M16
ITP52_RS01625	COG0612	Peptidase, M16
ITP52_RS01630	COG2814	Major facilitator Superfamily
ITP52_RS01635	COG2188	Transcriptional regulator
ITP52_RS01640	COG1674	ftsk spoiiie
ITP52_RS01640	COG4980	gas vesicle protein
ITP52_RS01650	COG0740	serine-type endopeptidase activity
ITP52_RS01655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ITP52_RS01660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITP52_RS01665	COG0527	aspartate kinase activity
ITP52_RS01670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ITP52_RS01675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ITP52_RS01680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITP52_RS01685	COG1873	PFAM PRC-barrel domain
ITP52_RS01690	COG0612	Peptidase, M16
ITP52_RS01695	COG0726	polysaccharide deacetylase
ITP52_RS01700	COG1185	polyribonucleotide nucleotidyltransferase activity
ITP52_RS01705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ITP52_RS01710	COG0196	riboflavin kinase activity
ITP52_RS01715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ITP52_RS01720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ITP52_RS01725	COG1550	Protein conserved in bacteria
ITP52_RS01730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ITP52_RS01735	COG1358	cellular component organization or biogenesis
ITP52_RS01740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ITP52_RS01745	COG0195	Participates in both transcription termination and antitermination
ITP52_RS01750	COG0779	Required for maturation of 30S ribosomal subunits
ITP52_RS01775	COG2176	DNA-directed DNA polymerase activity
ITP52_RS01780	COG0442	prolyl-tRNA aminoacylation
ITP52_RS01785	COG0750	zinc metalloprotease
ITP52_RS01790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ITP52_RS01795	COG4589	Belongs to the CDS family
ITP52_RS01800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ITP52_RS01805	COG0233	cytoplasmic translational termination
ITP52_RS01810	COG0528	UMP kinase activity
ITP52_RS01815	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ITP52_RS01820	COG0052	Belongs to the universal ribosomal protein uS2 family
ITP52_RS01830	COG1191	sigma factor activity
ITP52_RS01835	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ITP52_RS01840	COG1776	CheC inhibitor of MCP methylation
ITP52_RS01845	COG0835	chemotaxis
ITP52_RS01850	COG2198	Histidine kinase
ITP52_RS01850	COG0643	Histidine kinase
ITP52_RS01855	COG2201	protein-glutamate methylesterase activity
ITP52_RS01860	COG0455	bacterial-type flagellum organization
ITP52_RS01865	COG1419	protein localization to endoplasmic reticulum
ITP52_RS01870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ITP52_RS01875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ITP52_RS01880	COG1684	flagellar biosynthetic protein fliR
ITP52_RS01885	COG1987	bacterial-type flagellum assembly
ITP52_RS01890	COG1338	Plays a role in the flagellum-specific transport system
ITP52_RS01895	COG3190	flagellar
ITP52_RS01900	COG2201	protein-glutamate methylesterase activity
ITP52_RS01905	COG1776	CheC inhibitor of MCP methylation
ITP52_RS01905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITP52_RS01910	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITP52_RS01915	COG1580	Controls the rotational direction of flagella during chemotaxis
ITP52_RS01920	COG1582	Flagellar protein (FlbD)
ITP52_RS01925	COG4786	Flagellar basal body rod
ITP52_RS01930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ITP52_RS01935	COG3144	bacterial-type flagellum assembly
ITP52_RS01940	COG3334	PFAM MgtE intracellular
ITP52_RS01945	COG2882	bacterial-type flagellum organization
ITP52_RS01950	COG1157	protein secretion by the type III secretion system
ITP52_RS01955	COG1317	bacterial-type flagellum organization
ITP52_RS01960	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ITP52_RS01965	COG1766	The M ring may be actively involved in energy transduction
ITP52_RS01970	COG1677	Flagellar hook-basal body complex protein FliE
ITP52_RS01975	COG1558	bacterial-type flagellum-dependent cell motility
ITP52_RS01980	COG1815	bacterial-type flagellum-dependent cell motility
ITP52_RS01985	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ITP52_RS01990	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ITP52_RS01995	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ITP52_RS02000	COG4974	Belongs to the 'phage' integrase family
ITP52_RS02005	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ITP52_RS02010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITP52_RS02015	COG0758	DNA mediated transformation
ITP52_RS02020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ITP52_RS02025	COG0045	succinate-CoA ligase (ADP-forming) activity
ITP52_RS02030	COG2257	FlhB HrpN YscU SpaS Family
ITP52_RS02040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITP52_RS02045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ITP52_RS02050	COG0335	large ribosomal subunit rRNA binding
ITP52_RS02055	COG0336	Belongs to the RNA methyltransferase TrmD family
ITP52_RS02060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ITP52_RS02070	COG1837	Belongs to the UPF0109 family
ITP52_RS02075	COG0228	four-way junction DNA binding
ITP52_RS02080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ITP52_RS02085	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ITP52_RS02095	COG0552	protein localization to endoplasmic reticulum
ITP52_RS02100	COG1196	nuclear chromosome segregation
ITP52_RS02105	COG0571	ribonuclease III activity
ITP52_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS02120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ITP52_RS02125	COG0416	fatty acid biosynthetic process
ITP52_RS02130	COG2050	protein possibly involved in aromatic compounds catabolism
ITP52_RS02130	COG1349	DNA-binding transcription factor activity
ITP52_RS02135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ITP52_RS02140	COG1760	l-serine dehydratase
ITP52_RS02145	COG1760	l-serine dehydratase
ITP52_RS02150	COG1461	Dihydroxyacetone kinase
ITP52_RS02155	COG1302	Protein conserved in bacteria
ITP52_RS02160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ITP52_RS02170	COG1564	THIamine pyrophosphokinase
ITP52_RS02175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ITP52_RS02180	COG1162	GTPase activity
ITP52_RS02185	COG0515	serine threonine protein kinase
ITP52_RS02185	COG2815	serine threonine protein kinase
ITP52_RS02190	COG0631	protein serine/threonine phosphatase activity
ITP52_RS02195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ITP52_RS02200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ITP52_RS02200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITP52_RS02205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ITP52_RS02210	COG0242	peptide deformylase activity
ITP52_RS02215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITP52_RS02220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ITP52_RS02225	COG1758	RNA polymerase activity
ITP52_RS02230	COG0194	GDP metabolic process
ITP52_RS02240	COG1561	YicC-like family, N-terminal region
ITP52_RS02245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITP52_RS02250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ITP52_RS02255	COG1648	precorrin-2 dehydrogenase activity
ITP52_RS02260	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ITP52_RS02265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITP52_RS02270	COG0529	Catalyzes the synthesis of activated sulfate
ITP52_RS02275	COG2046	Belongs to the sulfate adenylyltransferase family
ITP52_RS02280	COG0306	phosphate transporter
ITP52_RS02285	COG0175	sulfate reduction
ITP52_RS02290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ITP52_RS02295	COG0284	orotidine-5'-phosphate decarboxylase activity
ITP52_RS02300	COG0167	dihydroorotate dehydrogenase activity
ITP52_RS02305	COG0543	2 iron, 2 sulfur cluster binding
ITP52_RS02310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITP52_RS02315	COG0505	Belongs to the CarA family
ITP52_RS02320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITP52_RS02325	COG0540	Belongs to the ATCase OTCase family
ITP52_RS02330	COG2233	PERMEase
ITP52_RS02335	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ITP52_RS02340	COG0564	pseudouridine synthase activity
ITP52_RS02345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ITP52_RS02350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITP52_RS02355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ITP52_RS02360	COG3599	regulation of cell shape
ITP52_RS02365	COG2302	S4 RNA-binding domain
ITP52_RS02370	COG0762	integral membrane protein
ITP52_RS02375	COG1799	cell septum assembly
ITP52_RS02380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ITP52_RS02385	COG1496	oxidoreductase activity
ITP52_RS02390	COG1873	PFAM PRC-barrel domain
ITP52_RS02395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITP52_RS02400	COG1119	ATPase activity
ITP52_RS02405	COG1191	sigma factor activity
ITP52_RS02410	COG1191	sigma factor activity
ITP52_RS02420	COG4412	M6 family metalloprotease domain protein
ITP52_RS02420	COG1404	Belongs to the peptidase S8 family
ITP52_RS02425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ITP52_RS02430	COG0849	cell division
ITP52_RS02435	COG3856	small basic protein
ITP52_RS02440	COG3879	Bacterial protein of unknown function (DUF881)
ITP52_RS02445	COG3879	Bacterial protein of unknown function (DUF881)
ITP52_RS02450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ITP52_RS02455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ITP52_RS02460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITP52_RS02465	COG0772	Belongs to the SEDS family
ITP52_RS02470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITP52_RS02475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITP52_RS02480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ITP52_RS02485	COG0768	penicillin binding
ITP52_RS02490	COG0768	penicillin binding
ITP52_RS02495	COG4839	cell division protein FtsL
ITP52_RS02500	COG0275	rRNA processing
ITP52_RS02505	COG2001	Belongs to the MraZ family
ITP52_RS02510	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ITP52_RS02515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITP52_RS02520	COG0454	-acetyltransferase
ITP52_RS02535	COG1399	metal-binding, possibly nucleic acid-binding protein
ITP52_RS02545	COG1323	Belongs to the UPF0348 family
ITP52_RS02550	COG3480	Lon protease (S16) C-terminal proteolytic domain
ITP52_RS02555	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITP52_RS02560	COG3314	Sporulation integral membrane protein YlbJ
ITP52_RS02565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ITP52_RS02570	COG0742	ribosomal rna small subunit methyltransferase
ITP52_RS02575	COG4471	UPF0298 protein
ITP52_RS02580	COG3679	Belongs to the UPF0342 family
ITP52_RS02595	COG2340	Cysteine-rich secretory protein family
ITP52_RS02600	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ITP52_RS02610	COG3336	cytochrome c oxidase
ITP52_RS02615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITP52_RS02620	COG1845	cytochrome c oxidase, subunit III
ITP52_RS02625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITP52_RS02630	COG2010	Cytochrome c
ITP52_RS02630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITP52_RS02635	COG0109	protoheme IX farnesyltransferase activity
ITP52_RS02640	COG1612	heme a metabolic process
ITP52_RS02645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ITP52_RS02650	COG0772	Belongs to the SEDS family
ITP52_RS02655	COG4838	Belongs to the UPF0358 family
ITP52_RS02660	COG2066	Belongs to the glutaminase family
ITP52_RS02665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ITP52_RS02670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ITP52_RS02680	COG4896	Protein conserved in bacteria
ITP52_RS02690	COG1217	gtp-binding protein TYPA
ITP52_RS02730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ITP52_RS02740	COG0483	inositol monophosphate 1-phosphatase activity
ITP52_RS02750	COG4493	Belongs to the UPF0637 family
ITP52_RS02755	COG4476	Belongs to the UPF0223 family
ITP52_RS02760	COG1982	Orn Lys Arg decarboxylase major
ITP52_RS02770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS02775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITP52_RS02780	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITP52_RS02785	COG0022	dehydrogenase e1 component
ITP52_RS02790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ITP52_RS02795	COG0497	DNA recombination
ITP52_RS02805	COG0242	peptide deformylase activity
ITP52_RS02810	COG0561	phosphatase activity
ITP52_RS02815	COG5503	Protein of unknown function (DUF1447)
ITP52_RS02820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ITP52_RS02825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ITP52_RS02830	COG0569	domain protein
ITP52_RS02835	COG2105	PFAM AIG2 family protein
ITP52_RS02835	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ITP52_RS02840	COG3852	Histidine kinase
ITP52_RS02845	COG2002	toxin-antitoxin pair type II binding
ITP52_RS02850	COG1077	Cell shape determining protein MreB Mrl
ITP52_RS02860	COG2309	aminopeptidase activity
ITP52_RS02865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ITP52_RS02870	COG0488	(ABC) transporter
ITP52_RS02880	COG0681	Belongs to the peptidase S26 family
ITP52_RS02885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITP52_RS02885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITP52_RS02885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS02890	COG1105	Belongs to the carbohydrate kinase PfkB family
ITP52_RS02895	COG1349	DNA-binding transcription factor activity
ITP52_RS02900	COG0577	efflux transmembrane transporter activity
ITP52_RS02905	COG1136	(ABC) transporter
ITP52_RS02910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITP52_RS02920	COG1132	(ABC) transporter
ITP52_RS02925	COG1132	(ABC) transporter
ITP52_RS02930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ITP52_RS02935	COG0314	molybdopterin synthase activity
ITP52_RS02940	COG1763	Mo-molybdopterin cofactor biosynthetic process
ITP52_RS02945	COG0303	'Molybdopterin
ITP52_RS02950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITP52_RS02955	COG0746	molybdenum cofactor guanylyltransferase activity
ITP52_RS02970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS02975	COG0450	alkyl hydroperoxide reductase
ITP52_RS02980	COG0668	transmembrane transport
ITP52_RS02995	COG2171	N-acyltransferase activity
ITP52_RS03000	COG0716	FMN binding
ITP52_RS03010	COG0716	FMN binding
ITP52_RS03015	COG0583	DNA-binding transcription factor activity
ITP52_RS03020	COG0517	IMP dehydrogenase activity
ITP52_RS03030	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ITP52_RS03035	COG4703	Protein of unknown function (DUF1797)
ITP52_RS03040	COG2200	EAL domain
ITP52_RS03045	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS03050	COG1408	metallophosphoesterase
ITP52_RS03055	COG1376	ErfK ybiS ycfS ynhG family protein
ITP52_RS03060	COG2814	Major facilitator Superfamily
ITP52_RS03070	COG0835	chemotaxis
ITP52_RS03070	COG0784	Response regulator, receiver
ITP52_RS03080	COG0436	Aminotransferase
ITP52_RS03085	COG4191	Histidine kinase
ITP52_RS03090	COG0768	penicillin binding
ITP52_RS03095	COG2340	Cysteine-rich secretory protein family
ITP52_RS03100	COG4257	antibiotic catabolic process
ITP52_RS03105	COG2084	Dehydrogenase
ITP52_RS03110	COG0840	transmembrane signaling receptor activity
ITP52_RS03115	COG0456	acetyltransferase
ITP52_RS03120	COG1533	DNA photolyase activity
ITP52_RS03130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ITP52_RS03135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS03140	COG1263	PTS System
ITP52_RS03140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS03140	COG2190	(PTS) system
ITP52_RS03145	COG3711	transcriptional antiterminator
ITP52_RS03150	COG1609	Transcriptional regulator
ITP52_RS03155	COG0006	proline dipeptidase activity
ITP52_RS03165	COG2217	Heavy metal translocating P-type atpase
ITP52_RS03170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS03175	COG2244	polysaccharide biosynthetic process
ITP52_RS03180	COG3773	Cell wall hydrolase
ITP52_RS03190	COG4873	Protein conserved in bacteria
ITP52_RS03205	COG1388	LysM domain
ITP52_RS03210	COG4641	Protein conserved in bacteria
ITP52_RS03210	COG1388	LysM domain
ITP52_RS03215	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS03220	COG1733	regulation of RNA biosynthetic process
ITP52_RS03225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ITP52_RS03230	COG0602	queuosine metabolic process
ITP52_RS03235	COG0720	synthase
ITP52_RS03240	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ITP52_RS03245	COG3949	Membrane
ITP52_RS03250	COG0542	response to heat
ITP52_RS03255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITP52_RS03260	COG1360	Flagellar Motor Protein
ITP52_RS03265	COG1846	Transcriptional regulator
ITP52_RS03270	COG3852	Histidine kinase
ITP52_RS03285	COG3339	Conserved Protein
ITP52_RS03290	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ITP52_RS03295	COG0235	Class ii aldolase
ITP52_RS03300	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ITP52_RS03305	COG1850	ribulose-bisphosphate carboxylase activity
ITP52_RS03310	COG0436	Aminotransferase
ITP52_RS03315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITP52_RS03320	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ITP52_RS03325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ITP52_RS03335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ITP52_RS03340	COG5002	protein histidine kinase activity
ITP52_RS03345	COG3594	Acyltransferase
ITP52_RS03360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITP52_RS03365	COG0501	Belongs to the peptidase M48B family
ITP52_RS03385	COG1191	sigma factor activity
ITP52_RS03390	COG0861	Integral membrane protein TerC family
ITP52_RS03395	COG0586	Pfam SNARE associated Golgi protein
ITP52_RS03400	COG3300	MHYT domain
ITP52_RS03400	COG5001	Diguanylate cyclase
ITP52_RS03405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ITP52_RS03410	COG3285	dna ligase
ITP52_RS03410	COG1793	dna ligase
ITP52_RS03415	COG0463	Glycosyl transferase, family 2
ITP52_RS03425	COG1408	metallophosphoesterase
ITP52_RS03430	COG0726	polysaccharide deacetylase
ITP52_RS03435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITP52_RS03440	COG1846	Transcriptional regulator
ITP52_RS03455	COG0789	Transcriptional regulator
ITP52_RS03460	COG2239	Acts as a magnesium transporter
ITP52_RS03470	COG3212	peptidase
ITP52_RS03475	COG3212	peptidase
ITP52_RS03480	COG5002	protein histidine kinase activity
ITP52_RS03480	COG3850	Histidine kinase
ITP52_RS03485	COG0745	RESPONSE REGULATOR receiver
ITP52_RS03495	COG4721	ABC-type cobalt transport system, permease component
ITP52_RS03500	COG1122	ATPase activity
ITP52_RS03505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ITP52_RS03510	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS03515	COG1404	Belongs to the peptidase S8 family
ITP52_RS03520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITP52_RS03525	COG0590	tRNA wobble adenosine to inosine editing
ITP52_RS03535	COG1764	response to oxidative stress
ITP52_RS03540	COG1846	Transcriptional regulator
ITP52_RS03545	COG1764	response to oxidative stress
ITP52_RS03550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ITP52_RS03555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ITP52_RS03560	COG0788	formyltetrahydrofolate deformylase activity
ITP52_RS03565	COG2076	Multidrug Resistance protein
ITP52_RS03570	COG2076	Multidrug Resistance protein
ITP52_RS03575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS03580	COG2318	DinB family
ITP52_RS03585	COG2323	membrane
ITP52_RS03595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ITP52_RS03595	COG1017	nitric oxide dioxygenase activity
ITP52_RS03600	COG1607	acyl-coa hydrolase
ITP52_RS03605	COG1834	amidinotransferase
ITP52_RS03610	COG2706	6-phosphogluconolactonase activity
ITP52_RS03615	COG4608	Belongs to the ABC transporter superfamily
ITP52_RS03620	COG0791	NLP P60 protein
ITP52_RS03625	COG4948	Mandelate Racemase Muconate Lactonizing
ITP52_RS03630	COG1619	proteins homologs of microcin C7 resistance protein MccF
ITP52_RS03635	COG4166	transmembrane transport
ITP52_RS03640	COG0444	Belongs to the ABC transporter superfamily
ITP52_RS03645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITP52_RS03650	COG0601	transmembrane transport
ITP52_RS03655	COG2362	D-Aminopeptidase
ITP52_RS03660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITP52_RS03665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITP52_RS03670	COG0463	Glycosyl transferase, family 2
ITP52_RS03675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ITP52_RS03685	COG0346	lactoylglutathione lyase activity
ITP52_RS03690	COG0531	amino acid
ITP52_RS03695	COG1392	Phosphate transport regulator
ITP52_RS03700	COG0306	phosphate transporter
ITP52_RS03720	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS03720	COG5632	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS03760	COG3778	Protein conserved in bacteria
ITP52_RS03765	COG3299	homolog of phage Mu protein gp47
ITP52_RS03770	COG3628	GPW Gp25 family protein
ITP52_RS03780	COG4193	domain, Protein
ITP52_RS03785	COG1652	LysM domain
ITP52_RS03790	COG5412	phage tail tape measure protein
ITP52_RS03790	COG3953	SLT domain
ITP52_RS03840	COG4653	Phage capsid family
ITP52_RS03845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITP52_RS03850	COG5518	Phage portal protein
ITP52_RS03855	COG1783	phage Terminase large subunit
ITP52_RS03860	COG3728	DNA packaging
ITP52_RS03860	COG5484	DNA packaging
ITP52_RS03865	COG1595	DNA-templated transcription, initiation
ITP52_RS03885	COG1484	DNA-dependent DNA replication
ITP52_RS03890	COG1522	sequence-specific DNA binding
ITP52_RS03900	COG1396	sequence-specific DNA binding
ITP52_RS03905	COG2856	Zn peptidase
ITP52_RS03910	COG3546	catalase activity
ITP52_RS03915	COG4195	phage-related replication protein
ITP52_RS03925	COG5632	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS03925	COG1388	LysM domain
ITP52_RS03925	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS03930	COG2350	Protein conserved in bacteria
ITP52_RS03940	COG0457	Tetratricopeptide repeat
ITP52_RS03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITP52_RS03950	COG2318	DinB family
ITP52_RS03955	COG0730	response to heat
ITP52_RS03960	COG2721	sulfolactate sulfo-lyase activity
ITP52_RS03965	COG0246	Mannitol dehydrogenase
ITP52_RS03970	COG1609	Transcriptional regulator
ITP52_RS03975	COG2271	Major facilitator Superfamily
ITP52_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS03985	COG1312	Catalyzes the dehydration of D-mannonate
ITP52_RS03990	COG1063	alcohol dehydrogenase
ITP52_RS03995	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ITP52_RS04000	COG2211	Major facilitator Superfamily
ITP52_RS04005	COG1904	glucuronate isomerase
ITP52_RS04010	COG1252	NADH dehydrogenase
ITP52_RS04020	COG4297	protein containing double-stranded beta helix domain
ITP52_RS04025	COG0697	spore germination
ITP52_RS04030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITP52_RS04035	COG0390	transport system, permease component
ITP52_RS04040	COG1587	Uroporphyrinogen-III synthase
ITP52_RS04060	COG1819	glycosyl
ITP52_RS04065	COG2124	cytochrome p450
ITP52_RS04085	COG2427	Protein of unknown function (DUF1641)
ITP52_RS04090	COG3383	formate dehydrogenase (NAD+) activity
ITP52_RS04100	COG2205	protein histidine kinase activity
ITP52_RS04120	COG0726	polysaccharide deacetylase
ITP52_RS04130	COG0109	protoheme IX farnesyltransferase activity
ITP52_RS04145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ITP52_RS04155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS04165	COG1482	cell wall glycoprotein biosynthetic process
ITP52_RS04170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITP52_RS04170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ITP52_RS04170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS04175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS04175	COG3711	transcriptional antiterminator
ITP52_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS04190	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ITP52_RS04215	COG5444	nuclease activity
ITP52_RS04250	COG5505	Protein of unknown function (DUF819)
ITP52_RS04255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS04260	COG0626	cystathionine gamma-synthase activity
ITP52_RS04265	COG0626	cystathionine gamma-synthase activity
ITP52_RS04270	COG2382	esterase
ITP52_RS04275	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ITP52_RS04280	COG2153	protein acetylation
ITP52_RS04290	COG0210	DNA helicase
ITP52_RS04345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ITP52_RS04350	COG0351	phosphomethylpyrimidine kinase
ITP52_RS04355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ITP52_RS04360	COG2022	thiamine diphosphate biosynthetic process
ITP52_RS04365	COG2104	thiamine diphosphate biosynthetic process
ITP52_RS04370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITP52_RS04375	COG0352	thiamine-phosphate diphosphorylase activity
ITP52_RS04380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ITP52_RS04385	COG0569	domain protein
ITP52_RS04385	COG0475	glutathione-regulated potassium exporter activity
ITP52_RS04390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ITP52_RS04395	COG0564	pseudouridine synthase activity
ITP52_RS04400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITP52_RS04405	COG2357	RelA SpoT domain protein
ITP52_RS04415	COG4116	CYTH
ITP52_RS04420	COG0741	lytic transglycosylase activity
ITP52_RS04425	COG2346	COG2346, Truncated hemoglobins
ITP52_RS04430	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ITP52_RS04440	COG1164	Oligoendopeptidase f
ITP52_RS04445	COG4469	Competence protein
ITP52_RS04455	COG4862	establishment of competence for transformation
ITP52_RS04465	COG0861	Integral membrane protein TerC family
ITP52_RS04470	COG1393	Belongs to the ArsC family
ITP52_RS04475	COG0456	acetyltransferase
ITP52_RS04480	COG2814	Major facilitator Superfamily
ITP52_RS04485	COG4608	Belongs to the ABC transporter superfamily
ITP52_RS04490	COG0444	Belongs to the ABC transporter superfamily
ITP52_RS04495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITP52_RS04505	COG4166	transmembrane transport
ITP52_RS04510	COG0180	Tryptophanyl-tRNA synthetase
ITP52_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ITP52_RS04525	COG0601	transmembrane transport
ITP52_RS04535	COG4608	Belongs to the ABC transporter superfamily
ITP52_RS04540	COG0444	Belongs to the ABC transporter superfamily
ITP52_RS04545	COG5504	Zn-dependent protease
ITP52_RS04550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ITP52_RS04555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITP52_RS04570	COG1744	ABC transporter substrate-binding protein PnrA-like
ITP52_RS04580	COG2267	carboxylic ester hydrolase activity
ITP52_RS04595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ITP52_RS04600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ITP52_RS04605	COG0505	Belongs to the CarA family
ITP52_RS04620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ITP52_RS04625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ITP52_RS04630	COG2271	Major facilitator Superfamily
ITP52_RS04635	COG0277	FAD linked oxidase domain protein
ITP52_RS04645	COG2151	metal-sulfur cluster biosynthetic enzyme
ITP52_RS04650	COG1073	alpha beta
ITP52_RS04655	COG0561	phosphatase activity
ITP52_RS04675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS04680	COG1307	EDD domain protein, DegV family
ITP52_RS04685	COG3227	Zinc metalloprotease (Elastase)
ITP52_RS04700	COG1695	Transcriptional regulator
ITP52_RS04720	COG2996	Protein conserved in bacteria
ITP52_RS04725	COG1666	GTP binding
ITP52_RS04730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ITP52_RS04730	COG0646	methionine synthase
ITP52_RS04735	COG2153	protein acetylation
ITP52_RS04740	COG0454	-acetyltransferase
ITP52_RS04745	COG2814	Major facilitator Superfamily
ITP52_RS04750	COG4948	Mandelate Racemase Muconate Lactonizing
ITP52_RS04755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS04760	COG1809	phosphosulfolactate synthase activity
ITP52_RS04765	COG2045	Belongs to the ComB family
ITP52_RS04770	COG0175	sulfate reduction
ITP52_RS04775	COG2046	Belongs to the sulfate adenylyltransferase family
ITP52_RS04780	COG0529	Catalyzes the synthesis of activated sulfate
ITP52_RS04785	COG2267	carboxylic ester hydrolase activity
ITP52_RS04790	COG1357	PFAM Pentapeptide repeats (8 copies)
ITP52_RS04795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS04800	COG1279	arginine transmembrane transporter activity
ITP52_RS04805	COG2318	DinB family
ITP52_RS04810	COG0673	inositol 2-dehydrogenase activity
ITP52_RS04815	COG1609	Transcriptional regulator
ITP52_RS04820	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS04820	COG2207	Transcriptional regulator
ITP52_RS04825	COG0534	Mate efflux family protein
ITP52_RS04830	COG1562	ergosterol biosynthetic process
ITP52_RS04835	COG2318	DinB family
ITP52_RS04840	COG0367	asparagine synthase
ITP52_RS04850	COG1404	Belongs to the peptidase S8 family
ITP52_RS04860	COG0179	Fumarylacetoacetate (FAA) hydrolase
ITP52_RS04865	COG5337	Spore coat protein CotH
ITP52_RS04905	COG1403	HNH endonuclease
ITP52_RS04910	COG0419	ATPase involved in DNA repair
ITP52_RS04915	COG0420	3'-5' exonuclease activity
ITP52_RS04920	COG1074	ATP-dependent DNA helicase activity
ITP52_RS04925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ITP52_RS04930	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ITP52_RS04940	COG4533	DNA binding
ITP52_RS04945	COG2814	Major facilitator Superfamily
ITP52_RS04945	COG0477	Major facilitator Superfamily
ITP52_RS04950	COG3180	Ammonia monooxygenase
ITP52_RS04955	COG1609	Transcriptional regulator
ITP52_RS04960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITP52_RS04965	COG0561	phosphatase activity
ITP52_RS04970	COG0673	inositol 2-dehydrogenase activity
ITP52_RS04975	COG0738	Major facilitator superfamily
ITP52_RS04985	COG1846	Transcriptional regulator
ITP52_RS04990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITP52_RS04995	COG0681	Belongs to the peptidase S26 family
ITP52_RS05000	COG0398	Pfam SNARE associated Golgi protein
ITP52_RS05015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITP52_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS05030	COG4903	ComK protein
ITP52_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS05045	COG0723	plastoquinol--plastocyanin reductase activity
ITP52_RS05045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITP52_RS05050	COG0840	transmembrane signaling receptor activity
ITP52_RS05055	COG1268	BioY protein
ITP52_RS05060	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS05065	COG0183	Belongs to the thiolase family
ITP52_RS05070	COG0406	alpha-ribazole phosphatase activity
ITP52_RS05075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ITP52_RS05080	COG0604	alcohol dehydrogenase
ITP52_RS05085	COG0456	acetyltransferase
ITP52_RS05095	COG0501	Belongs to the peptidase M48B family
ITP52_RS05105	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS05110	COG0702	epimerase
ITP52_RS05115	COG0095	Lipoate-protein ligase
ITP52_RS05120	COG1234	tRNA 3'-trailer cleavage
ITP52_RS05130	COG1301	dicarboxylic acid transport
ITP52_RS05135	COG4405	Protein conserved in bacteria
ITP52_RS05140	COG1363	Peptidase, m42
ITP52_RS05150	COG4377	Putative membrane peptidase family (DUF2324)
ITP52_RS05155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITP52_RS05160	COG1511	domain protein
ITP52_RS05165	COG1309	transcriptional regulator
ITP52_RS05170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ITP52_RS05175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ITP52_RS05180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ITP52_RS05185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITP52_RS05190	COG2329	Antibiotic biosynthesis monooxygenase
ITP52_RS05200	COG3069	C4-dicarboxylate transmembrane transporter activity
ITP52_RS05205	COG1473	amidohydrolase
ITP52_RS05215	COG4473	ABC transporter
ITP52_RS05220	COG1131	(ABC) transporter
ITP52_RS05225	COG0537	adenosine 5'-monophosphoramidase activity
ITP52_RS05230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ITP52_RS05245	COG4980	gas vesicle protein
ITP52_RS05250	COG1846	Transcriptional regulator
ITP52_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITP52_RS05290	COG3481	metal-dependent phosphohydrolase, HD sub domain
ITP52_RS05295	COG4717	serine-type aminopeptidase activity
ITP52_RS05300	COG0420	3'-5' exonuclease activity
ITP52_RS05305	COG1668	transmembrane transport
ITP52_RS05310	COG4152	abc transporter atp-binding protein
ITP52_RS05320	COG1024	Enoyl-CoA hydratase
ITP52_RS05330	COG0490	domain, Protein
ITP52_RS05335	COG0475	glutathione-regulated potassium exporter activity
ITP52_RS05340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITP52_RS05345	COG0561	phosphatase activity
ITP52_RS05350	COG4335	DNA alkylation repair
ITP52_RS05355	COG3679	Belongs to the UPF0342 family
ITP52_RS05360	COG4399	Belongs to the UPF0754 family
ITP52_RS05365	COG0189	ligase activity
ITP52_RS05370	COG0189	ligase activity
ITP52_RS05390	COG0702	epimerase
ITP52_RS05395	COG1132	(ABC) transporter
ITP52_RS05400	COG1132	(ABC) transporter
ITP52_RS05410	COG0589	response to stress
ITP52_RS05415	COG1757	Na H antiporter
ITP52_RS05420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITP52_RS05425	COG0726	polysaccharide deacetylase
ITP52_RS05430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ITP52_RS05435	COG0668	transmembrane transport
ITP52_RS05445	COG0584	glycerophosphoryl diester phosphodiesterase
ITP52_RS05450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ITP52_RS05455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ITP52_RS05460	COG1253	flavin adenine dinucleotide binding
ITP52_RS05470	COG0436	Aminotransferase
ITP52_RS05475	COG0789	Transcriptional regulator
ITP52_RS05480	COG1253	flavin adenine dinucleotide binding
ITP52_RS05485	COG0204	Acyl-transferase
ITP52_RS05490	COG0667	Aldo Keto reductase
ITP52_RS05495	COG1595	DNA-templated transcription, initiation
ITP52_RS05510	COG0456	acetyltransferase
ITP52_RS05515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS05520	COG0733	neurotransmitter:sodium symporter activity
ITP52_RS05525	COG0531	amino acid
ITP52_RS05530	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS05535	COG0372	Belongs to the citrate synthase family
ITP52_RS05540	COG0583	DNA-binding transcription factor activity
ITP52_RS05545	COG0791	NLP P60 protein
ITP52_RS05545	COG1388	LysM domain
ITP52_RS05550	COG1785	Belongs to the alkaline phosphatase family
ITP52_RS05555	COG2719	SpoVR family
ITP52_RS05560	COG0668	transmembrane transport
ITP52_RS05565	COG1959	2 iron, 2 sulfur cluster binding
ITP52_RS05570	COG1388	LysM domain
ITP52_RS05570	COG0791	NLP P60 protein
ITP52_RS05585	COG0431	NADPH-dependent FMN reductase
ITP52_RS05590	COG2197	response regulator
ITP52_RS05595	COG2203	Gaf domain
ITP52_RS05595	COG4585	Histidine kinase
ITP52_RS05600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITP52_RS05605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ITP52_RS05610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ITP52_RS05615	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ITP52_RS05620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ITP52_RS05625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITP52_RS05630	COG3153	acetyltransferase
ITP52_RS05630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ITP52_RS05635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITP52_RS05640	COG0517	IMP dehydrogenase activity
ITP52_RS05650	COG0564	pseudouridine synthase activity
ITP52_RS05655	COG3764	Sortase (surface protein transpeptidase)
ITP52_RS05660	COG1525	nuclease
ITP52_RS05660	COG4085	toxin activity
ITP52_RS05660	COG0737	Belongs to the 5'-nucleotidase family
ITP52_RS05665	COG5577	PFAM Coat F domain
ITP52_RS05695	COG1823	symporter activity
ITP52_RS05700	COG3706	GGDEF domain
ITP52_RS05705	COG1464	Belongs to the NlpA lipoprotein family
ITP52_RS05710	COG1278	Cold shock
ITP52_RS05715	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ITP52_RS05720	COG1131	(ABC) transporter
ITP52_RS05725	COG1131	(ABC) transporter
ITP52_RS05730	COG1725	Transcriptional regulator
ITP52_RS05750	COG0655	NAD(P)H dehydrogenase (quinone) activity
ITP52_RS05755	COG2814	Major facilitator Superfamily
ITP52_RS05760	COG1566	PFAM secretion protein HlyD family protein
ITP52_RS05765	COG1846	Transcriptional regulator
ITP52_RS05770	COG2718	Belongs to the UPF0229 family
ITP52_RS05775	COG2766	serine protein kinase
ITP52_RS05780	COG1664	Polymer-forming cytoskeletal
ITP52_RS05785	COG1664	Polymer-forming cytoskeletal
ITP52_RS05790	COG0789	Transcriptional regulator
ITP52_RS05795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ITP52_RS05805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ITP52_RS05810	COG3382	B3 4 domain protein
ITP52_RS05820	COG1476	TRANSCRIPTIONal
ITP52_RS05830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ITP52_RS05840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS05845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITP52_RS05850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITP52_RS05855	COG1116	anion transmembrane transporter activity
ITP52_RS05860	COG0753	catalase activity
ITP52_RS05875	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ITP52_RS05885	COG5577	PFAM Coat F domain
ITP52_RS05895	COG4326	sporulation control protein
ITP52_RS06005	COG0735	belongs to the Fur family
ITP52_RS06010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ITP52_RS06015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITP52_RS06020	COG4129	membrane
ITP52_RS06025	COG1132	(ABC) transporter
ITP52_RS06030	COG3557	Belongs to the UPF0374 family
ITP52_RS06045	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS06055	COG1194	a g-specific adenine glycosylase
ITP52_RS06060	COG1988	membrane-bound metal-dependent
ITP52_RS06065	COG4485	Bacterial membrane protein, YfhO
ITP52_RS06070	COG0463	Glycosyl transferase, family 2
ITP52_RS06075	COG0596	Alpha beta hydrolase
ITP52_RS06080	COG5658	integral membrane protein
ITP52_RS06085	COG3103	Sh3 type 3 domain protein
ITP52_RS06100	COG2814	Major facilitator Superfamily
ITP52_RS06110	COG2137	regulation of response to DNA damage stimulus
ITP52_RS06115	COG1090	epimerase
ITP52_RS06130	COG0778	Nitroreductase
ITP52_RS06135	COG0384	phenazine biosynthesis protein PhzF
ITP52_RS06140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS06145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS06150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS06155	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ITP52_RS06155	COG0392	lysyltransferase activity
ITP52_RS06160	COG1846	Transcriptional regulator
ITP52_RS06165	COG2814	Major facilitator Superfamily
ITP52_RS06170	COG2318	DinB family
ITP52_RS06175	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ITP52_RS06180	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITP52_RS06185	COG1695	Transcriptional regulator
ITP52_RS06190	COG0842	Transport permease protein
ITP52_RS06195	COG1511	domain protein
ITP52_RS06195	COG0842	Transport permease protein
ITP52_RS06200	COG1131	(ABC) transporter
ITP52_RS06205	COG2197	response regulator
ITP52_RS06210	COG4585	Histidine kinase
ITP52_RS06215	COG2514	catechol 2,3-dioxygenase activity
ITP52_RS06220	COG2259	Doxx family
ITP52_RS06225	COG1132	(ABC) transporter
ITP52_RS06230	COG1132	(ABC) transporter
ITP52_RS06235	COG5434	Belongs to the glycosyl hydrolase 28 family
ITP52_RS06240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS06240	COG1263	PTS System
ITP52_RS06245	COG1737	Transcriptional regulator
ITP52_RS06250	COG1486	melibiose metabolic process
ITP52_RS06255	COG4842	Belongs to the WXG100 family
ITP52_RS06280	COG1742	UPF0060 membrane protein
ITP52_RS06290	COG3284	Transcriptional regulator
ITP52_RS06295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITP52_RS06300	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITP52_RS06305	COG0022	dehydrogenase e1 component
ITP52_RS06310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ITP52_RS06315	COG4637	Psort location Cytoplasmic, score
ITP52_RS06320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITP52_RS06330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITP52_RS06335	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITP52_RS06340	COG0598	Magnesium transport protein CorA
ITP52_RS06345	COG2084	Dehydrogenase
ITP52_RS06350	COG0726	polysaccharide deacetylase
ITP52_RS06360	COG0535	radical SAM domain protein
ITP52_RS06365	COG0668	transmembrane transport
ITP52_RS06375	COG0387	Pfam Sodium calcium exchanger
ITP52_RS06380	COG0477	Major facilitator Superfamily
ITP52_RS06385	COG1295	ribonuclease BN
ITP52_RS06390	COG4980	gas vesicle protein
ITP52_RS06395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITP52_RS06400	COG4840	Belongs to the UPF0435 family
ITP52_RS06405	COG2814	Major facilitator Superfamily
ITP52_RS06410	COG0693	protein deglycase activity
ITP52_RS06415	COG0737	Belongs to the 5'-nucleotidase family
ITP52_RS06420	COG0778	Nitroreductase
ITP52_RS06425	COG2188	Transcriptional regulator
ITP52_RS06430	COG0366	Alpha amylase catalytic
ITP52_RS06435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS06435	COG1263	PTS System
ITP52_RS06440	COG0697	spore germination
ITP52_RS06455	COG0531	amino acid
ITP52_RS06460	COG1115	amino acid carrier protein
ITP52_RS06475	COG1368	sulfuric ester hydrolase activity
ITP52_RS06480	COG1263	PTS System
ITP52_RS06480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS06485	COG0024	Methionine aminopeptidase
ITP52_RS06505	COG2258	MOSC domain
ITP52_RS06510	COG1254	Belongs to the acylphosphatase family
ITP52_RS06515	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ITP52_RS06520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS06525	COG2851	Citrate transporter
ITP52_RS06530	COG3181	Tripartite tricarboxylate transporter family receptor
ITP52_RS06535	COG4565	transcriptional regulatory protein
ITP52_RS06540	COG3290	protein histidine kinase activity
ITP52_RS06545	COG0471	metal ion transport
ITP52_RS06550	COG3866	Pectate lyase
ITP52_RS06565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ITP52_RS06570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS06575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS06580	COG1120	ATPase activity
ITP52_RS06585	COG2130	NADP-dependent
ITP52_RS06590	COG0456	acetyltransferase
ITP52_RS06595	COG0513	Belongs to the DEAD box helicase family
ITP52_RS06600	COG0488	(ABC) transporter
ITP52_RS06620	COG1404	Belongs to the peptidase S8 family
ITP52_RS06625	COG2814	Major facilitator Superfamily
ITP52_RS06630	COG0789	Transcriptional regulator
ITP52_RS06640	COG0488	(ABC) transporter
ITP52_RS06645	COG0840	transmembrane signaling receptor activity
ITP52_RS06650	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS06655	COG0531	amino acid
ITP52_RS06660	COG1011	Hydrolase
ITP52_RS06665	COG2223	nitrite transmembrane transporter activity
ITP52_RS06670	COG1442	glycosyl transferase family 8
ITP52_RS06675	COG1216	Glycosyl transferase, family 2
ITP52_RS06680	COG1442	glycosyl transferase family 8
ITP52_RS06685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITP52_RS06690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ITP52_RS06695	COG1368	sulfuric ester hydrolase activity
ITP52_RS06700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITP52_RS06700	COG2124	cytochrome p450
ITP52_RS06715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ITP52_RS06720	COG1846	Transcriptional regulator
ITP52_RS06725	COG0697	spore germination
ITP52_RS06730	COG0670	Belongs to the BI1 family
ITP52_RS06735	COG5583	Uncharacterized small protein (DUF2292)
ITP52_RS06750	COG0346	lactoylglutathione lyase activity
ITP52_RS06755	COG2329	Antibiotic biosynthesis monooxygenase
ITP52_RS06760	COG2323	membrane
ITP52_RS06765	COG1486	melibiose metabolic process
ITP52_RS06770	COG0395	ABC-type sugar transport system, permease component
ITP52_RS06775	COG4209	transmembrane transport
ITP52_RS06780	COG1653	transport
ITP52_RS06790	COG1874	Beta-galactosidase
ITP52_RS06795	COG2755	lipolytic protein G-D-S-L family
ITP52_RS06800	COG3401	FG-GAP repeat protein
ITP52_RS06805	COG3401	FG-GAP repeat protein
ITP52_RS06810	COG5578	integral membrane protein
ITP52_RS06820	COG2755	lipolytic protein G-D-S-L family
ITP52_RS06825	COG2207	Transcriptional regulator
ITP52_RS06830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ITP52_RS06835	COG0395	ABC-type sugar transport system, permease component
ITP52_RS06840	COG1175	transmembrane transport
ITP52_RS06845	COG1653	transport
ITP52_RS06850	COG4753	response regulator
ITP52_RS06850	COG2207	Transcriptional regulator
ITP52_RS06855	COG2972	Histidine kinase
ITP52_RS06860	COG5578	integral membrane protein
ITP52_RS06870	COG0454	-acetyltransferase
ITP52_RS06875	COG3546	catalase activity
ITP52_RS06890	COG0702	epimerase
ITP52_RS06895	COG3631	Ketosteroid isomerase-related protein
ITP52_RS06900	COG1309	transcriptional regulator
ITP52_RS06910	COG0217	transcriptional regulatory protein
ITP52_RS06920	COG0457	Tetratricopeptide repeat
ITP52_RS06935	COG5444	nuclease activity
ITP52_RS06960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ITP52_RS06965	COG1597	lipid kinase activity
ITP52_RS06970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ITP52_RS06975	COG1309	transcriptional regulator
ITP52_RS06980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ITP52_RS06985	COG0154	amidase activity
ITP52_RS06990	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ITP52_RS06995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITP52_RS07000	COG1285	pathogenesis
ITP52_RS07005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITP52_RS07010	COG4851	CamS sex pheromone cAM373 precursor
ITP52_RS07015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ITP52_RS07020	COG0210	DNA helicase
ITP52_RS07025	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ITP52_RS07030	COG0069	glutamate synthase activity
ITP52_RS07035	COG4496	protein, YerC YecD
ITP52_RS07040	COG1470	cell adhesion involved in biofilm formation
ITP52_RS07045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ITP52_RS07055	COG0531	amino acid
ITP52_RS07060	COG1522	sequence-specific DNA binding
ITP52_RS07065	COG0151	Belongs to the GarS family
ITP52_RS07070	COG0138	bifunctional purine biosynthesis protein purh
ITP52_RS07075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ITP52_RS07080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ITP52_RS07085	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ITP52_RS07090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITP52_RS07095	COG0047	phosphoribosylformylglycinamidine synthase activity
ITP52_RS07100	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ITP52_RS07105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ITP52_RS07110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ITP52_RS07115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ITP52_RS07120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ITP52_RS07130	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ITP52_RS07140	COG3064	Membrane
ITP52_RS07145	COG2252	PERMEase
ITP52_RS07160	COG0519	Catalyzes the synthesis of GMP from XMP
ITP52_RS07160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ITP52_RS07165	COG1305	Transglutaminase-like
ITP52_RS07170	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ITP52_RS07175	COG0714	Associated with various cellular activities
ITP52_RS07180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITP52_RS07190	COG1113	amino acid transport
ITP52_RS07195	COG2132	Multicopper oxidase
ITP52_RS07205	COG2267	carboxylic ester hydrolase activity
ITP52_RS07220	COG0823	Involved in the tonB-independent uptake of proteins
ITP52_RS07225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ITP52_RS07230	COG1063	alcohol dehydrogenase
ITP52_RS07235	COG2814	Major facilitator Superfamily
ITP52_RS07245	COG4260	virion core protein, lumpy skin disease virus
ITP52_RS07250	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ITP52_RS07255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ITP52_RS07260	COG1842	Phage shock protein A
ITP52_RS07265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITP52_RS07270	COG2211	Major facilitator Superfamily
ITP52_RS07275	COG1063	alcohol dehydrogenase
ITP52_RS07280	COG0457	Tetratricopeptide repeat
ITP52_RS07285	COG1073	alpha beta
ITP52_RS07290	COG0459	protein refolding
ITP52_RS07300	COG1266	CAAX protease self-immunity
ITP52_RS07310	COG0805	protein transport
ITP52_RS07315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITP52_RS07320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ITP52_RS07325	COG0315	cyclic pyranopterin monophosphate synthase activity
ITP52_RS07330	COG0488	(ABC) transporter
ITP52_RS07335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ITP52_RS07340	COG0456	acetyltransferase
ITP52_RS07345	COG1214	PFAM Peptidase M22, glycoprotease
ITP52_RS07350	COG0802	atpase or kinase
ITP52_RS07355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ITP52_RS07400	COG4124	Belongs to the glycosyl hydrolase 26 family
ITP52_RS07405	COG1482	cell wall glycoprotein biosynthetic process
ITP52_RS07410	COG1940	carbohydrate kinase activity
ITP52_RS07415	COG2188	Transcriptional regulator
ITP52_RS07420	COG2723	6-phospho-beta-galactosidase activity
ITP52_RS07425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITP52_RS07430	COG1447	Phosphotransferase system cellobiose-specific component IIA
ITP52_RS07435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITP52_RS07440	COG2814	Major facilitator Superfamily
ITP52_RS07445	COG1388	LysM domain
ITP52_RS07450	COG1078	dGTPase activity
ITP52_RS07455	COG0454	-acetyltransferase
ITP52_RS07465	COG5646	InterPro IPR014922
ITP52_RS07470	COG1785	Belongs to the alkaline phosphatase family
ITP52_RS07480	COG1819	glycosyl
ITP52_RS07485	COG1388	LysM domain
ITP52_RS07485	COG3858	chitin binding
ITP52_RS07490	COG1802	Transcriptional regulator
ITP52_RS07495	COG0730	response to heat
ITP52_RS07500	COG2814	Major facilitator Superfamily
ITP52_RS07505	COG1846	Transcriptional regulator
ITP52_RS07510	COG0778	Nitroreductase
ITP52_RS07515	COG1033	growth of symbiont in host cell
ITP52_RS07515	COG2409	Drug exporters of the RND superfamily
ITP52_RS07520	COG1846	Transcriptional regulator
ITP52_RS07525	COG2318	DinB family
ITP52_RS07530	COG1113	amino acid transport
ITP52_RS07535	COG0488	(ABC) transporter
ITP52_RS07540	COG0456	acetyltransferase
ITP52_RS07550	COG1309	transcriptional regulator
ITP52_RS07565	COG0071	Belongs to the small heat shock protein (HSP20) family
ITP52_RS07570	COG2323	membrane
ITP52_RS07575	COG2323	membrane
ITP52_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS07595	COG2259	Doxx family
ITP52_RS07600	COG0346	lactoylglutathione lyase activity
ITP52_RS07605	COG0778	Nitroreductase
ITP52_RS07610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITP52_RS07615	COG0789	Transcriptional regulator
ITP52_RS07615	COG4978	Transcriptional regulator
ITP52_RS07620	COG1811	Na channel or pump
ITP52_RS07625	COG0596	Alpha beta hydrolase
ITP52_RS07630	COG2409	Drug exporters of the RND superfamily
ITP52_RS07635	COG2197	response regulator
ITP52_RS07640	COG4585	Histidine kinase
ITP52_RS07655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITP52_RS07660	COG0640	Transcriptional regulator
ITP52_RS07665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITP52_RS07670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS07675	COG0697	spore germination
ITP52_RS07680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS07690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITP52_RS07695	COG0640	Transcriptional regulator
ITP52_RS07700	COG1309	transcriptional regulator
ITP52_RS07705	COG2814	Major facilitator Superfamily
ITP52_RS07710	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITP52_RS07715	COG1733	regulation of RNA biosynthetic process
ITP52_RS07720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS07725	COG1733	regulation of RNA biosynthetic process
ITP52_RS07730	COG3545	Serine hydrolase
ITP52_RS07735	COG2030	dehydratase
ITP52_RS07740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS07745	COG0697	spore germination
ITP52_RS07750	COG1309	transcriptional regulator
ITP52_RS07765	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ITP52_RS07775	COG0477	Major facilitator Superfamily
ITP52_RS07780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS07785	COG3708	Transcriptional regulator
ITP52_RS07785	COG2207	Transcriptional regulator
ITP52_RS07790	COG0697	spore germination
ITP52_RS07795	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS07795	COG2207	Transcriptional regulator
ITP52_RS07800	COG0697	spore germination
ITP52_RS07805	COG1329	Transcriptional regulator
ITP52_RS07810	COG1278	Cold shock
ITP52_RS07815	COG3239	Fatty acid desaturase
ITP52_RS07825	COG1476	TRANSCRIPTIONal
ITP52_RS07835	COG5444	nuclease activity
ITP52_RS07915	COG3091	SprT-like family
ITP52_RS07925	COG2183	response to ionizing radiation
ITP52_RS07930	COG2208	phosphoserine phosphatase activity
ITP52_RS07935	COG1191	sigma factor activity
ITP52_RS07940	COG2172	sigma factor antagonist activity
ITP52_RS07945	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS07950	COG2208	phosphoserine phosphatase activity
ITP52_RS07955	COG2172	sigma factor antagonist activity
ITP52_RS07960	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS07965	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS07970	COG2337	Toxic component of a toxin-antitoxin (TA) module
ITP52_RS07975	COG0864	Transcriptional regulator
ITP52_RS07980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ITP52_RS07985	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ITP52_RS07990	COG0736	holo-[acyl-carrier-protein] synthase activity
ITP52_RS07995	COG0705	Rhomboid family
ITP52_RS08000	COG3428	Bacterial PH domain
ITP52_RS08005	COG3402	PFAM membrane-flanked domain
ITP52_RS08010	COG0513	Belongs to the DEAD box helicase family
ITP52_RS08015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ITP52_RS08020	COG1181	Belongs to the D-alanine--D-alanine ligase family
ITP52_RS08025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS08030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ITP52_RS08045	COG1960	acyl-CoA dehydrogenase activity
ITP52_RS08055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ITP52_RS08060	COG1131	(ABC) transporter
ITP52_RS08065	COG0628	permease
ITP52_RS08070	COG1301	dicarboxylic acid transport
ITP52_RS08075	COG4565	transcriptional regulatory protein
ITP52_RS08080	COG3290	protein histidine kinase activity
ITP52_RS08085	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ITP52_RS08090	COG3546	catalase activity
ITP52_RS08095	COG2329	Antibiotic biosynthesis monooxygenase
ITP52_RS08100	COG0662	Cupin 2, conserved barrel domain protein
ITP52_RS08105	COG3729	General stress protein
ITP52_RS08110	COG2217	Heavy metal translocating P-type atpase
ITP52_RS08115	COG4876	unkown
ITP52_RS08120	COG2261	transglycosylase associated protein
ITP52_RS08125	COG1914	H( )-stimulated, divalent metal cation uptake system
ITP52_RS08140	COG0028	Belongs to the TPP enzyme family
ITP52_RS08145	COG0494	nUDIX hydrolase
ITP52_RS08150	COG0531	amino acid
ITP52_RS08160	COG1215	transferase activity, transferring glycosyl groups
ITP52_RS08165	COG5298	Protein conserved in bacteria
ITP52_RS08170	COG3706	GGDEF domain
ITP52_RS08175	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ITP52_RS08180	COG0551	DNA topoisomerase type I activity
ITP52_RS08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ITP52_RS08185	COG1522	sequence-specific DNA binding
ITP52_RS08190	COG2814	Major facilitator Superfamily
ITP52_RS08200	COG3871	stress protein (general stress protein 26)
ITP52_RS08205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS08210	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS08220	COG2226	methyltransferase
ITP52_RS08225	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS08230	COG3711	transcriptional antiterminator
ITP52_RS08235	COG4989	oxidoreductase activity
ITP52_RS08240	COG0768	penicillin binding
ITP52_RS08245	COG2329	Antibiotic biosynthesis monooxygenase
ITP52_RS08255	COG2755	lipolytic protein G-D-S-L family
ITP52_RS08260	COG1414	Transcriptional regulator
ITP52_RS08265	COG1984	allophanate hydrolase subunit 2
ITP52_RS08270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ITP52_RS08275	COG4336	lyase activity
ITP52_RS08280	COG1914	H( )-stimulated, divalent metal cation uptake system
ITP52_RS08285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ITP52_RS08290	COG0561	phosphatase activity
ITP52_RS08300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITP52_RS08305	COG0412	Dienelactone hydrolase
ITP52_RS08310	COG0681	Belongs to the peptidase S26 family
ITP52_RS08315	COG0473	3-isopropylmalate dehydrogenase activity
ITP52_RS08320	COG0246	Mannitol dehydrogenase
ITP52_RS08335	COG1349	DNA-binding transcription factor activity
ITP52_RS08340	COG1276	copper resistance
ITP52_RS08340	COG2372	response to copper ion
ITP52_RS08345	COG4549	nuclear export factor GLE1
ITP52_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS08355	COG4975	Glucose uptake
ITP52_RS08360	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS08365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ITP52_RS08370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS08375	COG0640	Transcriptional regulator
ITP52_RS08380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ITP52_RS08385	COG0778	Nitroreductase
ITP52_RS08390	COG1309	transcriptional regulator
ITP52_RS08395	COG2814	Major facilitator Superfamily
ITP52_RS08400	COG4607	ABC-type enterochelin transport system periplasmic component
ITP52_RS08405	COG4604	ABC transporter, ATP-binding protein
ITP52_RS08410	COG4605	iron ion homeostasis
ITP52_RS08415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS08420	COG0527	aspartate kinase activity
ITP52_RS08440	COG0457	Tetratricopeptide repeat
ITP52_RS08445	COG3850	Histidine kinase
ITP52_RS08445	COG5002	protein histidine kinase activity
ITP52_RS08450	COG0745	RESPONSE REGULATOR receiver
ITP52_RS08455	COG0577	efflux transmembrane transporter activity
ITP52_RS08460	COG1136	(ABC) transporter
ITP52_RS08465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITP52_RS08475	COG0697	spore germination
ITP52_RS08485	COG5434	Belongs to the glycosyl hydrolase 28 family
ITP52_RS08490	COG3104	oligopeptide transport
ITP52_RS08495	COG0596	Alpha beta hydrolase
ITP52_RS08510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ITP52_RS08515	COG0163	prenyltransferase activity
ITP52_RS08520	COG0583	DNA-binding transcription factor activity
ITP52_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS08530	COG0765	amino acid transport
ITP52_RS08535	COG1126	abc transporter atp-binding protein
ITP52_RS08540	COG2364	Membrane
ITP52_RS08550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ITP52_RS08555	COG0697	spore germination
ITP52_RS08565	COG2814	Major facilitator Superfamily
ITP52_RS08570	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ITP52_RS08575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS08580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS08585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS08590	COG1733	regulation of RNA biosynthetic process
ITP52_RS08595	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ITP52_RS08600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ITP52_RS08605	COG0840	transmembrane signaling receptor activity
ITP52_RS08605	COG3290	protein histidine kinase activity
ITP52_RS08610	COG3209	COG3209 Rhs family protein
ITP52_RS08620	COG2723	6-phospho-beta-galactosidase activity
ITP52_RS08630	COG1714	RDD family
ITP52_RS08640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS08645	COG0765	amino acid transport
ITP52_RS08650	COG0523	cobalamin synthesis protein
ITP52_RS08660	COG1376	ErfK ybiS ycfS ynhG family protein
ITP52_RS08665	COG1469	GTP cyclohydrolase I activity
ITP52_RS08670	COG2223	nitrite transmembrane transporter activity
ITP52_RS08675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITP52_RS08680	COG0243	molybdopterin cofactor binding
ITP52_RS08685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITP52_RS08690	COG2146	nitrite reductase [NAD(P)H] activity
ITP52_RS08695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ITP52_RS08695	COG1587	Uroporphyrinogen-III synthase
ITP52_RS08700	COG0492	ferredoxin-NADP+ reductase activity
ITP52_RS08705	COG2267	carboxylic ester hydrolase activity
ITP52_RS08710	COG0701	Predicted permease
ITP52_RS08715	COG3689	TIGRFAM TIGR03943 family protein
ITP52_RS08720	COG2508	Transcriptional regulator
ITP52_RS08725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITP52_RS08730	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS08735	COG0506	proline dehydrogenase activity
ITP52_RS08740	COG3541	Predicted nucleotidyltransferase
ITP52_RS08745	COG3458	cephalosporin-C deacetylase activity
ITP52_RS08750	COG0583	DNA-binding transcription factor activity
ITP52_RS08755	COG2226	methyltransferase
ITP52_RS08760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ITP52_RS08765	COG1660	Displays ATPase and GTPase activities
ITP52_RS08770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ITP52_RS08775	COG3665	Urea carboxylase-associated protein
ITP52_RS08780	COG1113	amino acid transport
ITP52_RS08785	COG3403	YqcI/YcgG family
ITP52_RS08790	COG1280	lysine exporter protein (LysE YggA)
ITP52_RS08795	COG1846	Transcriptional regulator
ITP52_RS08800	COG2814	Major facilitator Superfamily
ITP52_RS08805	COG1620	l-lactate permease
ITP52_RS08810	COG0039	L-malate dehydrogenase activity
ITP52_RS08815	COG0366	Alpha amylase catalytic
ITP52_RS08825	COG1288	antiporter activity
ITP52_RS08830	COG1473	amidohydrolase
ITP52_RS08835	COG2113	Glycine betaine
ITP52_RS08840	COG4176	ABC-type proline glycine betaine transport system permease component
ITP52_RS08845	COG0517	IMP dehydrogenase activity
ITP52_RS08845	COG4175	Glycine betaine
ITP52_RS08850	COG0640	Transcriptional regulator
ITP52_RS08855	COG2814	Major facilitator Superfamily
ITP52_RS08860	COG0477	Major facilitator Superfamily
ITP52_RS08865	COG3853	Toxic anion resistance protein (TelA)
ITP52_RS08875	COG0861	Integral membrane protein TerC family
ITP52_RS08880	COG2310	stress, protein
ITP52_RS08885	COG2310	stress, protein
ITP52_RS08890	COG2310	stress, protein
ITP52_RS08895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS08900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITP52_RS08905	COG1121	(ABC) transporter
ITP52_RS08910	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITP52_RS08915	COG0366	Alpha amylase catalytic
ITP52_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS08925	COG0457	Tetratricopeptide repeat
ITP52_RS08930	COG1876	peptidase activity
ITP52_RS08935	COG1595	DNA-templated transcription, initiation
ITP52_RS08940	COG1595	DNA-templated transcription, initiation
ITP52_RS08955	COG0667	Aldo Keto reductase
ITP52_RS08960	COG1668	transmembrane transport
ITP52_RS08965	COG4555	ABC transporter
ITP52_RS08970	COG3279	Response regulator of the LytR AlgR family
ITP52_RS08975	COG3290	protein histidine kinase activity
ITP52_RS08980	COG3012	SEC-C Motif Domain Protein
ITP52_RS08980	COG1405	negative regulation of cell septum assembly
ITP52_RS08985	COG1714	RDD family
ITP52_RS08990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ITP52_RS08995	COG0252	asparaginase activity
ITP52_RS09000	COG1309	transcriptional regulator
ITP52_RS09005	COG0477	Major facilitator Superfamily
ITP52_RS09010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITP52_RS09015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ITP52_RS09020	COG0805	protein transport
ITP52_RS09025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ITP52_RS09030	COG3540	Alkaline phosphatase
ITP52_RS09040	COG2304	oxidoreductase activity
ITP52_RS09045	COG3773	Cell wall hydrolase
ITP52_RS09065	COG1131	(ABC) transporter
ITP52_RS09070	COG2205	protein histidine kinase activity
ITP52_RS09075	COG0745	RESPONSE REGULATOR receiver
ITP52_RS09080	COG0697	spore germination
ITP52_RS09090	COG3173	Aminoglycoside phosphotransferase
ITP52_RS09095	COG2721	sulfolactate sulfo-lyase activity
ITP52_RS09100	COG2186	Transcriptional regulator
ITP52_RS09105	COG4948	Mandelate Racemase Muconate Lactonizing
ITP52_RS09110	COG2271	Major facilitator Superfamily
ITP52_RS09115	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS09120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ITP52_RS09125	COG0784	Response regulator, receiver
ITP52_RS09130	COG4191	Histidine kinase
ITP52_RS09135	COG2066	Belongs to the glutaminase family
ITP52_RS09140	COG1115	amino acid carrier protein
ITP52_RS09145	COG2040	homocysteine
ITP52_RS09150	COG0833	amino acid
ITP52_RS09155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITP52_RS09165	COG2188	Transcriptional regulator
ITP52_RS09170	COG0363	glucosamine-6-phosphate deaminase activity
ITP52_RS09175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS09175	COG2190	(PTS) system
ITP52_RS09175	COG1263	PTS System
ITP52_RS09180	COG1301	dicarboxylic acid transport
ITP52_RS09185	COG1054	Belongs to the UPF0176 family
ITP52_RS09190	COG2312	Erythromycin esterase
ITP52_RS09200	COG0688	phosphatidylethanolamine metabolic process
ITP52_RS09205	COG0586	Pfam SNARE associated Golgi protein
ITP52_RS09210	COG1183	phosphatidylcholine synthase activity
ITP52_RS09215	COG0596	Alpha beta hydrolase
ITP52_RS09225	COG3591	Belongs to the peptidase S1B family
ITP52_RS09230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ITP52_RS09235	COG5444	nuclease activity
ITP52_RS09240	COG1397	ADP-ribosylglycohydrolase
ITP52_RS09245	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS09245	COG2207	Transcriptional regulator
ITP52_RS09250	COG0697	spore germination
ITP52_RS09255	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS09265	COG2271	Major facilitator Superfamily
ITP52_RS09270	COG0456	acetyltransferase
ITP52_RS09270	COG1846	Transcriptional regulator
ITP52_RS09280	COG2271	Major facilitator Superfamily
ITP52_RS09285	COG0584	glycerophosphoryl diester phosphodiesterase
ITP52_RS09290	COG0531	amino acid
ITP52_RS09300	COG2124	cytochrome p450
ITP52_RS09305	COG2602	Beta-lactamase
ITP52_RS09320	COG1113	amino acid transport
ITP52_RS09335	COG0515	serine threonine protein kinase
ITP52_RS09350	COG2814	Major facilitator Superfamily
ITP52_RS09355	COG0640	Transcriptional regulator
ITP52_RS09360	COG5609	conserved protein (DUF2294)
ITP52_RS09370	COG0288	reversible hydration of carbon dioxide
ITP52_RS09375	COG3002	Belongs to the UPF0753 family
ITP52_RS09380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ITP52_RS09385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ITP52_RS09390	COG2169	Transcriptional regulator
ITP52_RS09395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ITP52_RS09405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ITP52_RS09410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ITP52_RS09415	COG4856	YbbR-like protein
ITP52_RS09420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ITP52_RS09425	COG5662	AntiSigma factor
ITP52_RS09430	COG1595	DNA-templated transcription, initiation
ITP52_RS09460	COG1683	Conserved Protein
ITP52_RS09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ITP52_RS09470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ITP52_RS09475	COG1737	Transcriptional regulator
ITP52_RS09480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS09480	COG1263	PTS System
ITP52_RS09485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ITP52_RS09490	COG1472	Belongs to the glycosyl hydrolase 3 family
ITP52_RS09495	COG3876	Protein conserved in bacteria
ITP52_RS09500	COG2207	Transcriptional regulator
ITP52_RS09500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS09505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS09510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS09515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS09520	COG2819	hydrolase of the alpha beta superfamily
ITP52_RS09525	COG0385	Bile acid
ITP52_RS09530	COG0659	secondary active sulfate transmembrane transporter activity
ITP52_RS09615	COG0726	polysaccharide deacetylase
ITP52_RS09620	COG2194	sulfuric ester hydrolase activity
ITP52_RS09630	COG0489	protein tyrosine kinase activity
ITP52_RS09635	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS09645	COG2226	methyltransferase
ITP52_RS09650	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ITP52_RS09655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ITP52_RS09660	COG0101	tRNA pseudouridine synthase activity
ITP52_RS09665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ITP52_RS09670	COG1122	ATPase activity
ITP52_RS09675	COG1122	ATPase activity
ITP52_RS09680	COG0203	ribosomal protein L17
ITP52_RS09685	COG0202	RNA polymerase activity
ITP52_RS09690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ITP52_RS09695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ITP52_RS09700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ITP52_RS09715	COG0024	Methionine aminopeptidase
ITP52_RS09720	COG0563	adenylate kinase activity
ITP52_RS09725	COG0201	protein transport
ITP52_RS09730	COG0200	Binds to the 23S rRNA
ITP52_RS09740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ITP52_RS09745	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ITP52_RS09750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ITP52_RS09755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ITP52_RS09765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ITP52_RS09775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ITP52_RS09780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ITP52_RS09790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ITP52_RS09795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ITP52_RS09810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ITP52_RS09820	COG0088	Forms part of the polypeptide exit tunnel
ITP52_RS09825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ITP52_RS09835	COG0596	Alpha beta hydrolase
ITP52_RS09840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ITP52_RS09845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ITP52_RS09850	COG0049	tRNA binding
ITP52_RS09855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ITP52_RS09860	COG1358	cellular component organization or biogenesis
ITP52_RS09865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ITP52_RS09870	COG0085	RNA polymerase activity
ITP52_RS09875	COG2813	Specifically methylates the guanine in position
ITP52_RS09885	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ITP52_RS09890	COG0081	regulation of translation
ITP52_RS09900	COG0250	Participates in transcription elongation, termination and antitermination
ITP52_RS09905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITP52_RS09915	COG1595	DNA-templated transcription, initiation
ITP52_RS09920	COG3688	RNA-binding protein containing a PIN domain
ITP52_RS09925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITP52_RS09930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ITP52_RS09935	COG0215	cysteine-tRNA ligase activity
ITP52_RS09940	COG1045	serine acetyltransferase
ITP52_RS09945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ITP52_RS09950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ITP52_RS09955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ITP52_RS09960	COG4956	integral membrane protein (PIN domain superfamily)
ITP52_RS09965	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ITP52_RS09970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ITP52_RS09975	COG0542	response to heat
ITP52_RS09980	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ITP52_RS09985	COG3880	PFAM UvrB UvrC protein
ITP52_RS09990	COG4463	regulation of RNA biosynthetic process
ITP52_RS10070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ITP52_RS10075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ITP52_RS10080	COG1396	sequence-specific DNA binding
ITP52_RS10085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ITP52_RS10090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ITP52_RS10095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ITP52_RS10100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITP52_RS10105	COG0512	Glutamine amidotransferase of anthranilate synthase
ITP52_RS10110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITP52_RS10115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITP52_RS10120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ITP52_RS10125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ITP52_RS10130	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ITP52_RS10135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ITP52_RS10140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ITP52_RS10145	COG0037	tRNA processing
ITP52_RS10155	COG2304	oxidoreductase activity
ITP52_RS10160	COG2208	phosphoserine phosphatase activity
ITP52_RS10175	COG1098	S1 RNA binding domain
ITP52_RS10180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ITP52_RS10195	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ITP52_RS10200	COG3956	TIGRFAM MazG family protein
ITP52_RS10205	COG2244	polysaccharide biosynthetic process
ITP52_RS10210	COG2002	toxin-antitoxin pair type II binding
ITP52_RS10215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ITP52_RS10225	COG0193	aminoacyl-tRNA hydrolase activity
ITP52_RS10230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ITP52_RS10235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ITP52_RS10240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ITP52_RS10245	COG2088	sporulation resulting in formation of a cellular spore
ITP52_RS10250	COG0251	oxidation-reduction process
ITP52_RS10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITP52_RS10260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ITP52_RS10270	COG4466	Protein conserved in bacteria
ITP52_RS10280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ITP52_RS10285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ITP52_RS10290	COG3583	domain protein
ITP52_RS10290	COG3584	3D domain protein
ITP52_RS10295	COG0084	hydrolase, TatD family'
ITP52_RS10300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITP52_RS10300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITP52_RS10305	COG2002	toxin-antitoxin pair type II binding
ITP52_RS10310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ITP52_RS10315	COG2827	Endonuclease containing a URI domain
ITP52_RS10320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ITP52_RS10325	COG4467	Involved in initiation control of chromosome replication
ITP52_RS10330	COG1774	PSP1 C-terminal conserved region
ITP52_RS10335	COG0470	DNA polymerase III
ITP52_RS10340	COG1728	Protein conserved in bacteria
ITP52_RS10345	COG3870	Protein conserved in bacteria
ITP52_RS10350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ITP52_RS10355	COG1982	Orn Lys Arg decarboxylase major
ITP52_RS10360	COG3853	Toxic anion resistance protein (TelA)
ITP52_RS10365	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ITP52_RS10410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ITP52_RS10415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ITP52_RS10420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ITP52_RS10430	COG0590	tRNA wobble adenosine to inosine editing
ITP52_RS10435	COG1335	isochorismatase
ITP52_RS10440	COG1388	LysM domain
ITP52_RS10440	COG3858	chitin binding
ITP52_RS10445	COG1428	Deoxynucleoside kinase
ITP52_RS10450	COG1428	Deoxynucleoside kinase
ITP52_RS10460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ITP52_RS10465	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ITP52_RS10470	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ITP52_RS10475	COG1686	Belongs to the peptidase S11 family
ITP52_RS10480	COG0517	IMP dehydrogenase activity
ITP52_RS10480	COG0516	GMP reductase activity
ITP52_RS10515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ITP52_RS10520	COG0187	DNA topoisomerase II activity
ITP52_RS10530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ITP52_RS10535	COG2501	S4 domain
ITP52_RS10540	COG0592	DNA-directed DNA polymerase activity
ITP52_RS10545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ITP52_RS10555	COG0594	ribonuclease P activity
ITP52_RS10560	COG0706	membrane insertase activity
ITP52_RS10565	COG1847	R3H domain protein
ITP52_RS10570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ITP52_RS10575	COG0445	tRNA wobble uridine modification
ITP52_RS10580	COG0357	Ribosomal RNA small subunit methyltransferase G
ITP52_RS10585	COG1475	DNA binding
ITP52_RS10595	COG1192	Involved in chromosome partitioning
ITP52_RS10600	COG1475	DNA binding
ITP52_RS10610	COG3949	Membrane
ITP52_RS10615	COG4481	Protein conserved in bacteria
ITP52_RS10620	COG0243	molybdopterin cofactor binding
ITP52_RS10625	COG0012	GTP binding
ITP52_RS10630	COG0360	Binds together with S18 to 16S ribosomal RNA
ITP52_RS10635	COG0629	single-stranded DNA binding
ITP52_RS10640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ITP52_RS10645	COG0708	Exodeoxyribonuclease III
ITP52_RS10650	COG1609	Transcriptional regulator
ITP52_RS10655	COG0346	lactoylglutathione lyase activity
ITP52_RS10660	COG0110	maltose O-acetyltransferase activity
ITP52_RS10665	COG0477	Major facilitator Superfamily
ITP52_RS10665	COG2814	Major facilitator Superfamily
ITP52_RS10670	COG1266	CAAX protease self-immunity
ITP52_RS10675	COG1331	Highly conserved protein containing a thioredoxin domain
ITP52_RS10680	COG0697	spore germination
ITP52_RS10685	COG0789	Transcriptional regulator
ITP52_RS10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITP52_RS10710	COG2315	Protein conserved in bacteria
ITP52_RS10715	COG0456	acetyltransferase
ITP52_RS10720	COG2364	Membrane
ITP52_RS10725	COG2153	protein acetylation
ITP52_RS10730	COG1846	Transcriptional regulator
ITP52_RS10735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS10740	COG4319	ketosteroid isomerase
ITP52_RS10750	COG0789	Transcriptional regulator
ITP52_RS10750	COG4978	Transcriptional regulator
ITP52_RS10755	COG2271	Major facilitator Superfamily
ITP52_RS10770	COG1227	inorganic diphosphatase activity
ITP52_RS10775	COG1733	regulation of RNA biosynthetic process
ITP52_RS10780	COG5577	PFAM Coat F domain
ITP52_RS10790	COG4241	membrane
ITP52_RS10795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ITP52_RS10800	COG0359	binds to the 23S rRNA
ITP52_RS10805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ITP52_RS10810	COG2807	transmembrane transport
ITP52_RS10815	COG3093	addiction module antidote protein HigA
ITP52_RS10830	COG0305	Participates in initiation and elongation during chromosome replication
ITP52_RS10835	COG0346	lactoylglutathione lyase activity
ITP52_RS10865	COG0745	RESPONSE REGULATOR receiver
ITP52_RS10870	COG5002	protein histidine kinase activity
ITP52_RS10875	COG4863	YycH protein
ITP52_RS10880	COG4853	Protein conserved in bacteria
ITP52_RS10885	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ITP52_RS10890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITP52_RS10905	COG3829	transcription factor binding
ITP52_RS10910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ITP52_RS10915	COG0833	amino acid
ITP52_RS10920	COG0010	Belongs to the arginase family
ITP52_RS10930	COG0457	Tetratricopeptide repeat
ITP52_RS10935	COG0456	acetyltransferase
ITP52_RS10940	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ITP52_RS10960	COG1063	alcohol dehydrogenase
ITP52_RS10975	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ITP52_RS10985	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ITP52_RS10995	COG0535	radical SAM domain protein
ITP52_RS11000	COG1994	Peptidase M50
ITP52_RS11005	COG1131	(ABC) transporter
ITP52_RS11020	COG2188	Transcriptional regulator
ITP52_RS11040	COG3634	alkyl hydroperoxide reductase activity
ITP52_RS11045	COG0450	alkyl hydroperoxide reductase
ITP52_RS11050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITP52_RS11055	COG2610	gluconate transmembrane transporter activity
ITP52_RS11060	COG1070	Carbohydrate kinase
ITP52_RS11065	COG1802	Transcriptional regulator
ITP52_RS11070	COG1929	Belongs to the glycerate kinase type-1 family
ITP52_RS11075	COG5039	Polysaccharide pyruvyl transferase
ITP52_RS11080	COG1346	cytolysis
ITP52_RS11085	COG1380	Effector of murein hydrolase LrgA
ITP52_RS11090	COG1846	Transcriptional regulator
ITP52_RS11095	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS11100	COG1309	transcriptional regulator
ITP52_RS11105	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS11110	COG2311	Membrane
ITP52_RS11115	COG1714	RDD family
ITP52_RS11125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ITP52_RS11130	COG1714	RDD family
ITP52_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS11140	COG1309	transcriptional regulator
ITP52_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS11175	COG0326	Molecular chaperone. Has ATPase activity
ITP52_RS11180	COG2814	Major facilitator Superfamily
ITP52_RS11195	COG0667	Aldo Keto reductase
ITP52_RS11200	COG1349	DNA-binding transcription factor activity
ITP52_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS11215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITP52_RS11220	COG3962	Belongs to the TPP enzyme family
ITP52_RS11225	COG1082	Xylose isomerase domain protein TIM barrel
ITP52_RS11230	COG2814	Major facilitator Superfamily
ITP52_RS11235	COG0673	inositol 2-dehydrogenase activity
ITP52_RS11240	COG1082	Xylose isomerase domain protein TIM barrel
ITP52_RS11245	COG1082	Xylose isomerase domain protein TIM barrel
ITP52_RS11250	COG0191	fructose-bisphosphate aldolase activity
ITP52_RS11255	COG0745	RESPONSE REGULATOR receiver
ITP52_RS11260	COG2205	protein histidine kinase activity
ITP52_RS11265	COG1136	(ABC) transporter
ITP52_RS11270	COG0577	efflux transmembrane transporter activity
ITP52_RS11275	COG5294	Protein conserved in bacteria
ITP52_RS11280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS11310	COG0561	phosphatase activity
ITP52_RS11315	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ITP52_RS11320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS11325	COG0456	acetyltransferase
ITP52_RS11330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS11335	COG0765	amino acid transport
ITP52_RS11340	COG1126	abc transporter atp-binding protein
ITP52_RS11345	COG1473	amidohydrolase
ITP52_RS11350	COG2079	MmgE PrpD family protein
ITP52_RS11355	COG3192	ethanolamine utilization protein
ITP52_RS11365	COG2390	Transcriptional regulator
ITP52_RS11370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ITP52_RS11375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITP52_RS11380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ITP52_RS11385	COG0833	amino acid
ITP52_RS11390	COG0010	Belongs to the arginase family
ITP52_RS11395	COG1228	amidohydrolase
ITP52_RS11400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ITP52_RS11405	COG2986	histidine ammonia-lyase
ITP52_RS11420	COG3507	Belongs to the glycosyl hydrolase 43 family
ITP52_RS11465	COG2190	(PTS) system
ITP52_RS11465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS11465	COG1263	PTS System
ITP52_RS11470	COG2723	6-phospho-beta-galactosidase activity
ITP52_RS11475	COG0589	response to stress
ITP52_RS11480	COG0697	spore germination
ITP52_RS11485	COG3209	COG3209 Rhs family protein
ITP52_RS11530	COG3401	FG-GAP repeat protein
ITP52_RS11530	COG2755	lipolytic protein G-D-S-L family
ITP52_RS11535	COG0513	Belongs to the DEAD box helicase family
ITP52_RS11540	COG2270	Major facilitator Superfamily
ITP52_RS11550	COG3711	transcriptional antiterminator
ITP52_RS11555	COG2273	Hydrolase Family 16
ITP52_RS11560	COG2851	Citrate transporter
ITP52_RS11565	COG0693	protein deglycase activity
ITP52_RS11565	COG0753	catalase activity
ITP52_RS11580	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITP52_RS11585	COG0500	methyltransferase
ITP52_RS11590	COG2610	gluconate transmembrane transporter activity
ITP52_RS11595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ITP52_RS11600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ITP52_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS11610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITP52_RS11615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ITP52_RS11620	COG4894	glucomannan catabolic process
ITP52_RS11630	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITP52_RS11635	COG2197	response regulator
ITP52_RS11640	COG4585	Histidine kinase
ITP52_RS11650	COG0583	DNA-binding transcription factor activity
ITP52_RS11655	COG1881	PFAM PEBP family protein
ITP52_RS11660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ITP52_RS11670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS11675	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS11680	COG2508	Transcriptional regulator
ITP52_RS11685	COG3842	ATPase activity
ITP52_RS11690	COG0726	polysaccharide deacetylase
ITP52_RS11700	COG0501	Belongs to the peptidase M48B family
ITP52_RS11705	COG3493	citrate carrier protein
ITP52_RS11710	COG1271	oxidase subunit
ITP52_RS11715	COG1294	oxidase, subunit
ITP52_RS11720	COG4988	ABC transporter
ITP52_RS11725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ITP52_RS11730	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ITP52_RS11735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ITP52_RS11740	COG1595	DNA-templated transcription, initiation
ITP52_RS11760	COG1131	(ABC) transporter
ITP52_RS11765	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ITP52_RS11770	COG2814	Major facilitator Superfamily
ITP52_RS11775	COG0753	catalase activity
ITP52_RS11780	COG2094	Belongs to the DNA glycosylase MPG family
ITP52_RS11790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS11790	COG3711	transcriptional antiterminator
ITP52_RS11795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITP52_RS11800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITP52_RS11805	COG1447	Phosphotransferase system cellobiose-specific component IIA
ITP52_RS11810	COG1486	melibiose metabolic process
ITP52_RS11815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ITP52_RS11820	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ITP52_RS11825	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ITP52_RS11830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ITP52_RS11835	COG1696	Membrane protein involved in D-alanine export
ITP52_RS11840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS11855	COG1575	Belongs to the MenA family. Type 1 subfamily
ITP52_RS11860	COG2357	RelA SpoT domain protein
ITP52_RS11865	COG2814	Major facilitator Superfamily
ITP52_RS11880	COG2234	aminopeptidase activity
ITP52_RS11885	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITP52_RS11890	COG1846	Transcriptional regulator
ITP52_RS11895	COG5522	Integral membrane protein (intg_mem_TP0381)
ITP52_RS11900	COG1442	glycosyl transferase family 8
ITP52_RS11905	COG3711	transcriptional antiterminator
ITP52_RS11910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS11910	COG1263	PTS System
ITP52_RS11915	COG1404	Belongs to the peptidase S8 family
ITP52_RS11920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ITP52_RS11935	COG0346	lactoylglutathione lyase activity
ITP52_RS11940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ITP52_RS11945	COG4895	conserved protein (DUF2196)
ITP52_RS11950	COG2814	Major facilitator Superfamily
ITP52_RS11955	COG1346	cytolysis
ITP52_RS11960	COG1380	Effector of murein hydrolase LrgA
ITP52_RS11965	COG0583	DNA-binding transcription factor activity
ITP52_RS11970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ITP52_RS11975	COG0352	thiamine-phosphate diphosphorylase activity
ITP52_RS11980	COG0672	)-iron permease
ITP52_RS11985	COG2822	iron ion transport
ITP52_RS11990	COG2837	iron assimilation
ITP52_RS11995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ITP52_RS12000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ITP52_RS12005	COG3162	membrane
ITP52_RS12015	COG1309	transcriptional regulator
ITP52_RS12020	COG2246	polysaccharide biosynthetic process
ITP52_RS12025	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ITP52_RS12030	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ITP52_RS12035	COG2261	transglycosylase associated protein
ITP52_RS12040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ITP52_RS12045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ITP52_RS12050	COG1845	cytochrome c oxidase, subunit III
ITP52_RS12055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ITP52_RS12065	COG0772	Belongs to the SEDS family
ITP52_RS12070	COG0778	Nitroreductase
ITP52_RS12075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS12080	COG1404	Belongs to the peptidase S8 family
ITP52_RS12090	COG3711	transcriptional antiterminator
ITP52_RS12095	COG2116	formate transmembrane transporter activity
ITP52_RS12100	COG1263	PTS System
ITP52_RS12100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS12105	COG1621	beta-fructofuranosidase activity
ITP52_RS12115	COG0351	phosphomethylpyrimidine kinase
ITP52_RS12120	COG1695	Transcriptional regulator
ITP52_RS12135	COG1216	Glycosyl transferase, family 2
ITP52_RS12140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ITP52_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS12155	COG2233	PERMEase
ITP52_RS12160	COG2363	Small membrane protein
ITP52_RS12170	COG0463	Glycosyl transferase, family 2
ITP52_RS12175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ITP52_RS12180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITP52_RS12185	COG0456	acetyltransferase
ITP52_RS12190	COG2089	acid synthase
ITP52_RS12195	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ITP52_RS12200	COG3980	spore coat polysaccharide biosynthesis protein
ITP52_RS12205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ITP52_RS12210	COG1088	dTDP-glucose 4,6-dehydratase activity
ITP52_RS12215	COG1091	dTDP-4-dehydrorhamnose reductase activity
ITP52_RS12220	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ITP52_RS12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ITP52_RS12235	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS12240	COG4187	Peptidase family M20/M25/M40
ITP52_RS12245	COG0833	amino acid
ITP52_RS12250	COG2814	Major facilitator Superfamily
ITP52_RS12255	COG0077	Prephenate dehydratase
ITP52_RS12260	COG1917	Cupin 2, conserved barrel domain protein
ITP52_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS12270	COG0151	Belongs to the GarS family
ITP52_RS12275	COG2814	Major facilitator Superfamily
ITP52_RS12280	COG0436	Aminotransferase
ITP52_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS12290	COG3253	May function as heme-dependent peroxidase
ITP52_RS12295	COG0280	phosphate acetyltransferase
ITP52_RS12300	COG0583	DNA-binding transcription factor activity
ITP52_RS12305	COG0095	Lipoate-protein ligase
ITP52_RS12310	COG0697	spore germination
ITP52_RS12320	COG4844	belongs to the
ITP52_RS12325	COG1078	dGTPase activity
ITP52_RS12330	COG3465	dGTPase activity
ITP52_RS12335	COG1959	2 iron, 2 sulfur cluster binding
ITP52_RS12340	COG0477	Major facilitator Superfamily
ITP52_RS12345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ITP52_RS12350	COG1846	Transcriptional regulator
ITP52_RS12355	COG1942	4-Oxalocrotonate Tautomerase
ITP52_RS12360	COG1994	Peptidase M50
ITP52_RS12375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITP52_RS12380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ITP52_RS12385	COG0010	Belongs to the arginase family
ITP52_RS12395	COG1131	(ABC) transporter
ITP52_RS12425	COG0457	Tetratricopeptide repeat
ITP52_RS12435	COG3391	amine dehydrogenase activity
ITP52_RS12440	COG3391	amine dehydrogenase activity
ITP52_RS12450	COG0612	Peptidase, M16
ITP52_RS12455	COG0612	Peptidase, M16
ITP52_RS12460	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ITP52_RS12465	COG1131	(ABC) transporter
ITP52_RS12475	COG0535	radical SAM domain protein
ITP52_RS12490	COG4506	Protein conserved in bacteria
ITP52_RS12495	COG0018	arginyl-trna synthetase
ITP52_RS12500	COG2223	nitrite transmembrane transporter activity
ITP52_RS12505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITP52_RS12515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ITP52_RS12520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ITP52_RS12525	COG1140	nitrate reductase beta subunit
ITP52_RS12530	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ITP52_RS12535	COG2181	nitrate reductase activity
ITP52_RS12540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITP52_RS12545	COG1132	(ABC) transporter
ITP52_RS12550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITP52_RS12560	COG4294	response to UV
ITP52_RS12565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITP52_RS12570	COG2181	nitrate reductase activity
ITP52_RS12570	COG0247	lactate metabolic process
ITP52_RS12575	COG1960	acyl-CoA dehydrogenase activity
ITP52_RS12580	COG3343	RNA polymerase activity
ITP52_RS12585	COG0504	CTP synthase activity
ITP52_RS12590	COG4821	SIS domain
ITP52_RS12595	COG2204	response regulator
ITP52_RS12600	COG0191	fructose-bisphosphate aldolase activity
ITP52_RS12605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ITP52_RS12610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITP52_RS12615	COG1494	fructose-1,6-bisphosphatase
ITP52_RS12625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ITP52_RS12635	COG1435	thymidine kinase activity
ITP52_RS12640	COG0281	malic enzyme
ITP52_RS12645	COG0679	Auxin Efflux Carrier
ITP52_RS12650	COG0789	Transcriptional regulator
ITP52_RS12655	COG0346	lactoylglutathione lyase activity
ITP52_RS12660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ITP52_RS12665	COG2890	protein-(glutamine-N5) methyltransferase activity
ITP52_RS12685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ITP52_RS12690	COG0009	L-threonylcarbamoyladenylate synthase
ITP52_RS12695	COG1971	Probably functions as a manganese efflux pump
ITP52_RS12700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITP52_RS12705	COG0698	ribose 5-phosphate isomerase
ITP52_RS12710	COG4475	Protein of unknown function (DUF436)
ITP52_RS12715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ITP52_RS12720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ITP52_RS12730	COG0356	it plays a direct role in the translocation of protons across the membrane
ITP52_RS12740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ITP52_RS12745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ITP52_RS12750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ITP52_RS12755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ITP52_RS12760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ITP52_RS12765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ITP52_RS12775	COG4836	Membrane
ITP52_RS12785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ITP52_RS12790	COG2385	sporulation resulting in formation of a cellular spore
ITP52_RS12795	COG2304	oxidoreductase activity
ITP52_RS12805	COG2304	oxidoreductase activity
ITP52_RS12815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ITP52_RS12820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ITP52_RS12825	COG0457	Tetratricopeptide repeat
ITP52_RS12830	COG1994	Peptidase M50
ITP52_RS12835	COG3237	CsbD-like
ITP52_RS12850	COG0831	urea catabolic process
ITP52_RS12855	COG0832	Belongs to the urease beta subunit family
ITP52_RS12860	COG0804	urea catabolic process
ITP52_RS12865	COG1959	2 iron, 2 sulfur cluster binding
ITP52_RS12870	COG2910	NAD(P)H-binding
ITP52_RS12880	COG0789	Transcriptional regulator
ITP52_RS12885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ITP52_RS12905	COG1247	-acetyltransferase
ITP52_RS12910	COG0739	heme binding
ITP52_RS12920	COG0671	phosphoesterase, PA-phosphatase related
ITP52_RS12925	COG0347	Belongs to the P(II) protein family
ITP52_RS12930	COG0004	ammonium transporteR
ITP52_RS12940	COG1335	isochorismatase
ITP52_RS12945	COG0477	Major facilitator Superfamily
ITP52_RS12950	COG1953	Uracil, thiamine, allantoin
ITP52_RS12955	COG3420	alginic acid biosynthetic process
ITP52_RS12960	COG2814	Major facilitator Superfamily
ITP52_RS12965	COG1846	Transcriptional regulator
ITP52_RS12975	COG1609	Transcriptional regulator
ITP52_RS12980	COG1077	Cell shape determining protein MreB Mrl
ITP52_RS12985	COG4786	Flagellar basal body rod
ITP52_RS12990	COG4786	Flagellar basal body rod
ITP52_RS12995	COG0457	Tetratricopeptide repeat
ITP52_RS13000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ITP52_RS13005	COG1970	mechanosensitive ion channel activity
ITP52_RS13010	COG0745	RESPONSE REGULATOR receiver
ITP52_RS13010	COG2972	Histidine kinase
ITP52_RS13015	COG3279	Response regulator of the LytR AlgR family
ITP52_RS13025	COG3764	Sortase (surface protein transpeptidase)
ITP52_RS13040	COG0629	single-stranded DNA binding
ITP52_RS13045	COG1349	DNA-binding transcription factor activity
ITP52_RS13050	COG0561	phosphatase activity
ITP52_RS13055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITP52_RS13060	COG4715	Zinc finger, swim domain protein
ITP52_RS13070	COG3944	biosynthesis protein
ITP52_RS13075	COG0489	protein tyrosine kinase activity
ITP52_RS13080	COG4464	protein tyrosine phosphatase activity
ITP52_RS13085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ITP52_RS13090	COG3878	Protein conserved in bacteria
ITP52_RS13110	COG5444	nuclease activity
ITP52_RS13125	COG2059	Chromate
ITP52_RS13130	COG2059	Chromate
ITP52_RS13135	COG1522	sequence-specific DNA binding
ITP52_RS13140	COG0405	Gamma-glutamyltransferase
ITP52_RS13150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ITP52_RS13160	COG5337	Spore coat protein CotH
ITP52_RS13175	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ITP52_RS13180	COG0583	DNA-binding transcription factor activity
ITP52_RS13185	COG0028	Belongs to the TPP enzyme family
ITP52_RS13190	COG3527	Alpha-acetolactate decarboxylase
ITP52_RS13195	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITP52_RS13205	COG3103	Sh3 type 3 domain protein
ITP52_RS13210	COG1879	ABC-type sugar transport system periplasmic component
ITP52_RS13215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ITP52_RS13220	COG1129	ABC transporter
ITP52_RS13225	COG1869	D-ribose catabolic process
ITP52_RS13230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITP52_RS13235	COG1609	Transcriptional regulator
ITP52_RS13240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ITP52_RS13250	COG2843	Capsule synthesis protein
ITP52_RS13260	COG0791	NLP P60 protein
ITP52_RS13265	COG0561	phosphatase activity
ITP52_RS13270	COG1316	TRANSCRIPTIONal
ITP52_RS13275	COG2814	Major facilitator Superfamily
ITP52_RS13285	COG0814	amino acid
ITP52_RS13290	COG0697	spore germination
ITP52_RS13295	COG1482	cell wall glycoprotein biosynthetic process
ITP52_RS13300	COG4193	domain, Protein
ITP52_RS13345	COG0463	Glycosyl transferase, family 2
ITP52_RS13350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ITP52_RS13350	COG1215	transferase activity, transferring glycosyl groups
ITP52_RS13355	COG1682	transport, permease protein
ITP52_RS13360	COG1134	teichoic acid transport
ITP52_RS13365	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ITP52_RS13385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ITP52_RS13390	COG1316	TRANSCRIPTIONal
ITP52_RS13400	COG2385	sporulation resulting in formation of a cellular spore
ITP52_RS13400	COG2247	cell wall binding repeat
ITP52_RS13405	COG2247	cell wall binding repeat
ITP52_RS13405	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS13420	COG2244	polysaccharide biosynthetic process
ITP52_RS13425	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS13425	COG0297	glycogen (starch) synthase activity
ITP52_RS13430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ITP52_RS13435	COG3307	-O-antigen
ITP52_RS13440	COG3206	protein involved in exopolysaccharide biosynthesis
ITP52_RS13445	COG1215	transferase activity, transferring glycosyl groups
ITP52_RS13450	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS13455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ITP52_RS13460	COG1316	TRANSCRIPTIONal
ITP52_RS13465	COG1739	Uncharacterized protein family UPF0029
ITP52_RS13470	COG4585	Histidine kinase
ITP52_RS13475	COG2197	response regulator
ITP52_RS13480	COG1307	EDD domain protein, DegV family
ITP52_RS13485	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ITP52_RS13495	COG1040	competence protein
ITP52_RS13505	COG2747	anti-sigma28 factor FlgM
ITP52_RS13510	COG3418	PFAM FlgN family protein
ITP52_RS13515	COG1256	bacterial-type flagellum assembly
ITP52_RS13515	COG4786	Flagellar basal body rod
ITP52_RS13520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITP52_RS13530	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ITP52_RS13535	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ITP52_RS13540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ITP52_RS13545	COG1334	flagellar protein FlaG
ITP52_RS13550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ITP52_RS13555	COG1516	flagellar protein fliS
ITP52_RS13570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ITP52_RS13575	COG0653	protein targeting
ITP52_RS13585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS13590	COG2010	Cytochrome c
ITP52_RS13595	COG2884	Cell division ATP-binding protein ftsE
ITP52_RS13600	COG2177	Part of the ABC transporter FtsEX involved in
ITP52_RS13605	COG0793	Belongs to the peptidase S41A family
ITP52_RS13605	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS13615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITP52_RS13620	COG2814	Major facilitator Superfamily
ITP52_RS13625	COG1309	transcriptional regulator
ITP52_RS13630	COG3848	Pyruvate phosphate dikinase
ITP52_RS13630	COG0574	Belongs to the PEP-utilizing enzyme family
ITP52_RS13635	COG4897	Protein conserved in bacteria
ITP52_RS13640	COG0556	nucleotide-excision repair
ITP52_RS13645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ITP52_RS13665	COG3595	metallopeptidase activity
ITP52_RS13670	COG1983	PspC domain protein
ITP52_RS13675	COG1950	PFAM Membrane protein of
ITP52_RS13680	COG2814	Major facilitator Superfamily
ITP52_RS13685	COG1846	Transcriptional regulator
ITP52_RS13700	COG1846	Transcriptional regulator
ITP52_RS13705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ITP52_RS13710	COG2188	Transcriptional regulator
ITP52_RS13715	COG0363	glucosamine-6-phosphate deaminase activity
ITP52_RS13720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ITP52_RS13725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ITP52_RS13730	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ITP52_RS13735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ITP52_RS13740	COG0546	phosphoglycolate phosphatase activity
ITP52_RS13745	COG0110	maltose O-acetyltransferase activity
ITP52_RS13750	COG5297	Belongs to the glycosyl hydrolase family 6
ITP52_RS13755	COG4990	cell redox homeostasis
ITP52_RS13760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ITP52_RS13765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ITP52_RS13770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ITP52_RS13775	COG0131	Imidazoleglycerol-phosphate dehydratase
ITP52_RS13780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ITP52_RS13785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ITP52_RS13790	COG0107	imidazoleglycerol-phosphate synthase activity
ITP52_RS13795	COG0140	phosphoribosyl-ATP diphosphatase activity
ITP52_RS13795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ITP52_RS13815	COG1132	(ABC) transporter
ITP52_RS13820	COG0457	Tetratricopeptide repeat
ITP52_RS13825	COG3883	PFAM NLP P60 protein
ITP52_RS13825	COG0791	NLP P60 protein
ITP52_RS13830	COG0492	ferredoxin-NADP+ reductase activity
ITP52_RS13835	COG1051	belongs to the nudix hydrolase family
ITP52_RS13840	COG1660	Displays ATPase and GTPase activities
ITP52_RS13845	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ITP52_RS13850	COG1481	regulation of sporulation
ITP52_RS13855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS13860	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ITP52_RS13875	COG0745	RESPONSE REGULATOR receiver
ITP52_RS13880	COG5002	protein histidine kinase activity
ITP52_RS13885	COG1136	(ABC) transporter
ITP52_RS13890	COG0577	efflux transmembrane transporter activity
ITP52_RS13895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ITP52_RS13900	COG0288	reversible hydration of carbon dioxide
ITP52_RS13910	COG1694	Mazg nucleotide pyrophosphohydrolase
ITP52_RS13915	COG1611	Belongs to the LOG family
ITP52_RS13920	COG1609	Transcriptional regulator
ITP52_RS13925	COG0366	Alpha amylase catalytic
ITP52_RS13930	COG2182	Extracellular solute-binding protein
ITP52_RS13935	COG1175	transmembrane transport
ITP52_RS13940	COG3833	ABC-type maltose transport systems, permease component
ITP52_RS13945	COG5521	maltodextrose utilization protein MalA
ITP52_RS13950	COG1554	hydrolase, family 65, central catalytic
ITP52_RS13955	COG0366	Alpha amylase catalytic
ITP52_RS13960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ITP52_RS13965	COG0740	serine-type endopeptidase activity
ITP52_RS13980	COG2076	Multidrug Resistance protein
ITP52_RS13985	COG2076	Multidrug Resistance protein
ITP52_RS13990	COG1309	transcriptional regulator
ITP52_RS13995	COG0531	amino acid
ITP52_RS14000	COG1621	beta-fructofuranosidase activity
ITP52_RS14005	COG1621	beta-fructofuranosidase activity
ITP52_RS14010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ITP52_RS14015	COG1794	racemase activity, acting on amino acids and derivatives
ITP52_RS14025	COG3479	Phenolic acid decarboxylase
ITP52_RS14035	COG2272	Belongs to the type-B carboxylesterase lipase family
ITP52_RS14040	COG1396	sequence-specific DNA binding
ITP52_RS14045	COG3944	biosynthesis protein
ITP52_RS14050	COG0489	protein tyrosine kinase activity
ITP52_RS14055	COG1086	Polysaccharide biosynthesis protein
ITP52_RS14060	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS14065	COG1215	transferase activity, transferring glycosyl groups
ITP52_RS14070	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS14080	COG1216	Glycosyl transferase, family 2
ITP52_RS14085	COG5039	Polysaccharide pyruvyl transferase
ITP52_RS14090	COG1216	Glycosyl transferase, family 2
ITP52_RS14095	COG2244	polysaccharide biosynthetic process
ITP52_RS14100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ITP52_RS14105	COG0110	maltose O-acetyltransferase activity
ITP52_RS14110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ITP52_RS14115	COG5039	Polysaccharide pyruvyl transferase
ITP52_RS14125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ITP52_RS14135	COG2186	Transcriptional regulator
ITP52_RS14140	COG1609	Transcriptional regulator
ITP52_RS14145	COG2182	Extracellular solute-binding protein
ITP52_RS14150	COG1175	transmembrane transport
ITP52_RS14155	COG3833	ABC-type maltose transport systems, permease component
ITP52_RS14160	COG1874	Beta-galactosidase
ITP52_RS14165	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ITP52_RS14170	COG2208	phosphoserine phosphatase activity
ITP52_RS14175	COG0596	Alpha beta hydrolase
ITP52_RS14180	COG1131	(ABC) transporter
ITP52_RS14185	COG0842	Transport permease protein
ITP52_RS14190	COG4585	Histidine kinase
ITP52_RS14195	COG2197	response regulator
ITP52_RS14200	COG0247	lactate metabolic process
ITP52_RS14205	COG1139	Iron-sulfur cluster binding protein
ITP52_RS14210	COG1556	Lactate utilization protein
ITP52_RS14215	COG3858	chitin binding
ITP52_RS14220	COG1113	amino acid transport
ITP52_RS14225	COG0697	spore germination
ITP52_RS14230	COG0583	DNA-binding transcription factor activity
ITP52_RS14235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS14240	COG1609	Transcriptional regulator
ITP52_RS14245	COG2814	Major facilitator Superfamily
ITP52_RS14250	COG2390	Transcriptional regulator
ITP52_RS14255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITP52_RS14260	COG0126	phosphoglycerate kinase activity
ITP52_RS14265	COG0149	triose-phosphate isomerase activity
ITP52_RS14270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ITP52_RS14275	COG0148	phosphopyruvate hydratase activity
ITP52_RS14280	COG0456	acetyltransferase
ITP52_RS14285	COG4640	response to antibiotic
ITP52_RS14290	COG3064	Membrane
ITP52_RS14300	COG2095	MarC family integral membrane protein
ITP52_RS14305	COG1510	regulation of RNA biosynthetic process
ITP52_RS14310	COG1125	glycine betaine transport
ITP52_RS14310	COG0517	IMP dehydrogenase activity
ITP52_RS14315	COG1174	glycine betaine transport
ITP52_RS14320	COG1732	Glycine betaine
ITP52_RS14330	COG1510	regulation of RNA biosynthetic process
ITP52_RS14335	COG1125	glycine betaine transport
ITP52_RS14335	COG0517	IMP dehydrogenase activity
ITP52_RS14340	COG1174	glycine betaine transport
ITP52_RS14345	COG1732	Glycine betaine
ITP52_RS14350	COG1174	glycine betaine transport
ITP52_RS14380	COG1131	(ABC) transporter
ITP52_RS14405	COG0840	transmembrane signaling receptor activity
ITP52_RS14410	COG1733	regulation of RNA biosynthetic process
ITP52_RS14415	COG1396	sequence-specific DNA binding
ITP52_RS14420	COG1396	sequence-specific DNA binding
ITP52_RS14425	COG1476	TRANSCRIPTIONal
ITP52_RS14430	COG0596	Alpha beta hydrolase
ITP52_RS14435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ITP52_RS14440	COG1647	Serine aminopeptidase, S33
ITP52_RS14445	COG0557	exoribonuclease II activity
ITP52_RS14450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ITP52_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS14480	COG1309	transcriptional regulator
ITP52_RS14485	COG2076	Multidrug Resistance protein
ITP52_RS14495	COG1289	transmembrane transporter activity
ITP52_RS14500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ITP52_RS14505	COG0673	inositol 2-dehydrogenase activity
ITP52_RS14510	COG1937	Protein conserved in bacteria
ITP52_RS14515	COG2608	mercury ion transmembrane transporter activity
ITP52_RS14520	COG2217	Heavy metal translocating P-type atpase
ITP52_RS14525	COG2217	Heavy metal translocating P-type atpase
ITP52_RS14530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ITP52_RS14535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ITP52_RS14540	COG2860	membrane
ITP52_RS14550	COG3973	AAA domain
ITP52_RS14555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITP52_RS14560	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ITP52_RS14565	COG0025	NhaP-type Na H and K H
ITP52_RS14575	COG0656	L-ascorbic acid biosynthetic process
ITP52_RS14580	COG4149	molybdate abc transporter
ITP52_RS14585	COG0725	ABC transporter, periplasmic molybdate-binding protein
ITP52_RS14590	COG1910	domain protein
ITP52_RS14595	COG1368	sulfuric ester hydrolase activity
ITP52_RS14600	COG1988	membrane-bound metal-dependent
ITP52_RS14610	COG0531	amino acid
ITP52_RS14615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS14620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS14625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS14630	COG1120	ATPase activity
ITP52_RS14635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ITP52_RS14640	COG1136	(ABC) transporter
ITP52_RS14645	COG0577	efflux transmembrane transporter activity
ITP52_RS14655	COG2140	Oxalate decarboxylase
ITP52_RS14665	COG1191	sigma factor activity
ITP52_RS14675	COG0745	RESPONSE REGULATOR receiver
ITP52_RS14680	COG2205	protein histidine kinase activity
ITP52_RS14685	COG3386	PFAM SMP-30 Gluconolaconase
ITP52_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS14695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ITP52_RS14700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ITP52_RS14705	COG1120	ATPase activity
ITP52_RS14710	COG2096	Adenosyltransferase
ITP52_RS14715	COG2814	Major facilitator Superfamily
ITP52_RS14720	COG4758	membrane
ITP52_RS14725	COG1842	Phage shock protein A
ITP52_RS14730	COG3595	metallopeptidase activity
ITP52_RS14735	COG4758	membrane
ITP52_RS14740	COG4585	Histidine kinase
ITP52_RS14745	COG2197	response regulator
ITP52_RS14755	COG0814	amino acid
ITP52_RS14760	COG0697	spore germination
ITP52_RS14770	COG0114	fumarate hydratase activity
ITP52_RS14775	COG1309	transcriptional regulator
ITP52_RS14785	COG2770	Histidine kinase
ITP52_RS14785	COG2205	protein histidine kinase activity
ITP52_RS14790	COG0745	RESPONSE REGULATOR receiver
ITP52_RS14795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ITP52_RS14800	COG0783	Belongs to the Dps family
ITP52_RS14805	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS14820	COG1120	ATPase activity
ITP52_RS14830	COG0583	DNA-binding transcription factor activity
ITP52_RS14840	COG1942	4-Oxalocrotonate Tautomerase
ITP52_RS14845	COG0477	Major facilitator Superfamily
ITP52_RS14850	COG1846	Transcriptional regulator
ITP52_RS14855	COG5577	PFAM Coat F domain
ITP52_RS14865	COG0506	proline dehydrogenase activity
ITP52_RS14875	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITP52_RS14875	COG1024	Enoyl-CoA hydratase
ITP52_RS14880	COG0183	Belongs to the thiolase family
ITP52_RS14885	COG1960	acyl-CoA dehydrogenase activity
ITP52_RS14890	COG1393	Belongs to the ArsC family
ITP52_RS14895	COG0509	glycine decarboxylation via glycine cleavage system
ITP52_RS14905	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ITP52_RS14910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS14920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ITP52_RS14925	COG2011	ABC-type metal ion transport system permease component
ITP52_RS14930	COG1464	Belongs to the NlpA lipoprotein family
ITP52_RS14935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ITP52_RS14945	COG0396	ATPase activity
ITP52_RS14950	COG0719	Fe-S assembly protein
ITP52_RS14955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ITP52_RS14960	COG0822	iron-sulfur transferase activity
ITP52_RS14965	COG0719	Fe-S assembly protein
ITP52_RS14970	COG0640	Transcriptional regulator
ITP52_RS14975	COG0346	lactoylglutathione lyase activity
ITP52_RS14990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ITP52_RS14995	COG0322	excinuclease ABC activity
ITP52_RS15000	COG2222	sugar isomerase
ITP52_RS15005	COG1653	transport
ITP52_RS15010	COG1175	transmembrane transport
ITP52_RS15015	COG0395	ABC-type sugar transport system, permease component
ITP52_RS15020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITP52_RS15025	COG2188	Transcriptional regulator
ITP52_RS15030	COG3842	ATPase activity
ITP52_RS15035	COG2356	endonuclease I
ITP52_RS15045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITP52_RS15050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ITP52_RS15055	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ITP52_RS15060	COG2068	MobA-Related Protein
ITP52_RS15065	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ITP52_RS15070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ITP52_RS15075	COG2080	2 iron, 2 sulfur cluster binding
ITP52_RS15085	COG2351	hydroxyisourate hydrolase activity
ITP52_RS15090	COG3648	Uricase
ITP52_RS15090	COG3195	allantoin biosynthetic process
ITP52_RS15095	COG2233	PERMEase
ITP52_RS15100	COG2233	PERMEase
ITP52_RS15105	COG2508	Transcriptional regulator
ITP52_RS15110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ITP52_RS15120	COG1801	Protein of unknown function DUF72
ITP52_RS15125	COG0730	response to heat
ITP52_RS15130	COG0737	Belongs to the 5'-nucleotidase family
ITP52_RS15135	COG3377	Domain of unknown function (DUF1805)
ITP52_RS15145	COG0739	heme binding
ITP52_RS15150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ITP52_RS15160	COG4470	Protein conserved in bacteria
ITP52_RS15165	COG2445	Protein of unknown function DUF86
ITP52_RS15170	COG0647	UMP catabolic process
ITP52_RS15175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITP52_RS15180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITP52_RS15185	COG0460	homoserine dehydrogenase
ITP52_RS15190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ITP52_RS15195	COG0083	homoserine kinase activity
ITP52_RS15200	COG4946	Tricorn protease homolog
ITP52_RS15200	COG1506	peptidase
ITP52_RS15200	COG0823	Involved in the tonB-independent uptake of proteins
ITP52_RS15205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ITP52_RS15210	COG4837	Protein of unknown function (DUF1462)
ITP52_RS15215	COG1252	NADH dehydrogenase
ITP52_RS15220	COG4844	belongs to the
ITP52_RS15225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ITP52_RS15230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ITP52_RS15235	COG0316	Belongs to the HesB IscA family
ITP52_RS15240	COG0456	acetyltransferase
ITP52_RS15245	COG2808	Putative FMN-binding domain
ITP52_RS15250	COG0516	GMP reductase activity
ITP52_RS15260	COG0492	ferredoxin-NADP+ reductase activity
ITP52_RS15265	COG1252	NADH dehydrogenase
ITP52_RS15280	COG3584	3D domain protein
ITP52_RS15285	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ITP52_RS15290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ITP52_RS15295	COG2056	Na+-H+ antiporter family
ITP52_RS15300	COG1268	BioY protein
ITP52_RS15305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ITP52_RS15310	COG2819	hydrolase of the alpha beta superfamily
ITP52_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS15320	COG1169	isochorismate synthase
ITP52_RS15325	COG1021	2,3-dihydroxybenzoate-AMP ligase
ITP52_RS15330	COG3433	isochorismatase activity
ITP52_RS15330	COG1535	isochorismatase
ITP52_RS15335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ITP52_RS15340	COG3251	PFAM MbtH domain protein
ITP52_RS15345	COG5634	Uncharacterized conserved protein (DUF2278)
ITP52_RS15350	COG0686	Belongs to the AlaDH PNT family
ITP52_RS15355	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ITP52_RS15355	COG2508	Transcriptional regulator
ITP52_RS15360	COG4842	Belongs to the WXG100 family
ITP52_RS15365	COG5417	Belongs to the EsaB family
ITP52_RS15370	COG4499	WXG100 protein secretion system (Wss), protein YukC
ITP52_RS15375	COG1674	ftsk spoiiie
ITP52_RS15375	COG0433	COG0433 Predicted ATPase
ITP52_RS15380	COG1511	domain protein
ITP52_RS15390	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS15395	COG1418	mRNA catabolic process
ITP52_RS15410	COG0628	permease
ITP52_RS15425	COG5506	Protein of unknown function (DUF1694)
ITP52_RS15430	COG1335	isochorismatase
ITP52_RS15435	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ITP52_RS15440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ITP52_RS15455	COG0142	geranyltranstransferase activity
ITP52_RS15465	COG4585	Histidine kinase
ITP52_RS15470	COG2197	response regulator
ITP52_RS15475	COG2050	protein possibly involved in aromatic compounds catabolism
ITP52_RS15480	COG1320	monovalent cation:proton antiporter activity
ITP52_RS15485	COG2212	antiporter activity
ITP52_RS15490	COG1863	multisubunit Na H antiporter MnhE subunit
ITP52_RS15495	COG0651	ATP synthesis coupled electron transport
ITP52_RS15500	COG1006	Multisubunit Na H antiporter MnhC subunit
ITP52_RS15505	COG2111	Na H antiporter
ITP52_RS15510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ITP52_RS15510	COG2111	Na H antiporter
ITP52_RS15520	COG3493	citrate carrier protein
ITP52_RS15525	COG1079	Belongs to the binding-protein-dependent transport system permease family
ITP52_RS15530	COG4603	Belongs to the binding-protein-dependent transport system permease family
ITP52_RS15535	COG3845	ABC transporter
ITP52_RS15540	COG1744	ABC transporter substrate-binding protein PnrA-like
ITP52_RS15545	COG4565	transcriptional regulatory protein
ITP52_RS15550	COG3290	protein histidine kinase activity
ITP52_RS15560	COG3011	Protein conserved in bacteria
ITP52_RS15565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITP52_RS15570	COG2814	Major facilitator Superfamily
ITP52_RS15575	COG5018	Exonuclease
ITP52_RS15585	COG2205	protein histidine kinase activity
ITP52_RS15590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ITP52_RS15600	COG2267	carboxylic ester hydrolase activity
ITP52_RS15605	COG1522	sequence-specific DNA binding
ITP52_RS15610	COG0436	Aminotransferase
ITP52_RS15615	COG1098	S1 RNA binding domain
ITP52_RS15620	COG2155	Conserved Protein
ITP52_RS15625	COG1979	alcohol dehydrogenase
ITP52_RS15630	COG1979	alcohol dehydrogenase
ITP52_RS15635	COG0166	Belongs to the GPI family
ITP52_RS15650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ITP52_RS15665	COG2738	Putative neutral zinc metallopeptidase
ITP52_RS15670	COG1253	flavin adenine dinucleotide binding
ITP52_RS15675	COG0366	Alpha amylase catalytic
ITP52_RS15685	COG0432	Pfam Uncharacterised protein family UPF0047
ITP52_RS15700	COG0840	transmembrane signaling receptor activity
ITP52_RS15705	COG0840	transmembrane signaling receptor activity
ITP52_RS15710	COG0840	transmembrane signaling receptor activity
ITP52_RS15715	COG0840	transmembrane signaling receptor activity
ITP52_RS15720	COG3347	Dehydrogenase
ITP52_RS15720	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS15725	COG1349	DNA-binding transcription factor activity
ITP52_RS15730	COG1070	Carbohydrate kinase
ITP52_RS15735	COG3254	rhamnose metabolic process
ITP52_RS15740	COG4806	L-rhamnose isomerase
ITP52_RS15745	COG0673	inositol 2-dehydrogenase activity
ITP52_RS15750	COG0628	permease
ITP52_RS15755	COG1968	undecaprenyl-diphosphatase activity
ITP52_RS15765	COG5553	Cysteine dioxygenase type I
ITP52_RS15770	COG0477	Major facilitator Superfamily
ITP52_RS15775	COG1705	Flagellar rod assembly protein muramidase FlgJ
ITP52_RS15780	COG4682	membrane
ITP52_RS15785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ITP52_RS15790	COG0569	domain protein
ITP52_RS15800	COG1510	regulation of RNA biosynthetic process
ITP52_RS15805	COG1012	belongs to the aldehyde dehydrogenase family
ITP52_RS15810	COG1454	alcohol dehydrogenase
ITP52_RS15820	COG2318	DinB family
ITP52_RS15825	COG1585	Membrane protein implicated in regulation of membrane protease activity
ITP52_RS15830	COG2268	Band 7 protein
ITP52_RS15835	COG1247	-acetyltransferase
ITP52_RS15840	COG3859	Proton-coupled thiamine transporter YuaJ
ITP52_RS15965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ITP52_RS15970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITP52_RS15975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ITP52_RS15980	COG0297	glycogen (starch) synthase activity
ITP52_RS15985	COG0058	SHG alpha-glucan phosphorylase activity
ITP52_RS15990	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ITP52_RS15995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITP52_RS16000	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS16005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITP52_RS16015	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS16020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITP52_RS16025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ITP52_RS16030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ITP52_RS16035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ITP52_RS16040	COG1169	isochorismate synthase
ITP52_RS16045	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ITP52_RS16050	COG0596	Alpha beta hydrolase
ITP52_RS16055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ITP52_RS16060	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS16065	COG4948	Mandelate Racemase Muconate Lactonizing
ITP52_RS16070	COG0803	Belongs to the bacterial solute-binding protein 9 family
ITP52_RS16075	COG1121	(ABC) transporter
ITP52_RS16080	COG1321	iron dependent repressor
ITP52_RS16080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITP52_RS16085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ITP52_RS16095	COG1294	oxidase, subunit
ITP52_RS16100	COG1271	oxidase subunit
ITP52_RS16105	COG0254	rRNA binding
ITP52_RS16110	COG0288	reversible hydration of carbon dioxide
ITP52_RS16115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ITP52_RS16120	COG1854	S-ribosylhomocysteine lyase activity
ITP52_RS16135	COG0783	Belongs to the Dps family
ITP52_RS16140	COG4824	toxin secretion phage lysis holin
ITP52_RS16145	COG0494	nUDIX hydrolase
ITP52_RS16150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ITP52_RS16155	COG1116	anion transmembrane transporter activity
ITP52_RS16160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ITP52_RS16165	COG1506	peptidase
ITP52_RS16175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ITP52_RS16180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ITP52_RS16185	COG0367	asparagine synthase
ITP52_RS16190	COG1113	amino acid transport
ITP52_RS16195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ITP52_RS16200	COG2267	carboxylic ester hydrolase activity
ITP52_RS16210	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ITP52_RS16215	COG1242	4 iron, 4 sulfur cluster binding
ITP52_RS16230	COG1725	Transcriptional regulator
ITP52_RS16235	COG1131	(ABC) transporter
ITP52_RS16250	COG1136	(ABC) transporter
ITP52_RS16255	COG0577	efflux transmembrane transporter activity
ITP52_RS16260	COG0745	RESPONSE REGULATOR receiver
ITP52_RS16265	COG2205	protein histidine kinase activity
ITP52_RS16270	COG1136	(ABC) transporter
ITP52_RS16275	COG0577	efflux transmembrane transporter activity
ITP52_RS16280	COG2433	Pfam Transposase IS66
ITP52_RS16285	COG2814	Major facilitator Superfamily
ITP52_RS16290	COG2202	Pas domain
ITP52_RS16290	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS16300	COG0495	leucyl-tRNA aminoacylation
ITP52_RS16305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITP52_RS16310	COG1486	melibiose metabolic process
ITP52_RS16315	COG0395	ABC-type sugar transport system, permease component
ITP52_RS16320	COG1175	transmembrane transport
ITP52_RS16325	COG1653	transport
ITP52_RS16330	COG1609	Transcriptional regulator
ITP52_RS16335	COG1073	alpha beta
ITP52_RS16345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ITP52_RS16350	COG0156	8-amino-7-oxononanoate synthase activity
ITP52_RS16360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ITP52_RS16365	COG2124	cytochrome p450
ITP52_RS16370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ITP52_RS16375	COG0395	ABC-type sugar transport system, permease component
ITP52_RS16380	COG1653	transport
ITP52_RS16385	COG2207	Transcriptional regulator
ITP52_RS16390	COG4209	transmembrane transport
ITP52_RS16395	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ITP52_RS16400	COG1653	transport
ITP52_RS16405	COG0673	inositol 2-dehydrogenase activity
ITP52_RS16410	COG5578	integral membrane protein
ITP52_RS16420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ITP52_RS16425	COG2081	HI0933 family
ITP52_RS16430	COG2244	polysaccharide biosynthetic process
ITP52_RS16435	COG1187	pseudouridine synthase activity
ITP52_RS16440	COG1349	DNA-binding transcription factor activity
ITP52_RS16445	COG1131	(ABC) transporter
ITP52_RS16450	COG4473	ABC transporter
ITP52_RS16455	COG2252	PERMEase
ITP52_RS16460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ITP52_RS16465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITP52_RS16470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ITP52_RS16480	COG1597	lipid kinase activity
ITP52_RS16485	COG1523	belongs to the glycosyl hydrolase 13 family
ITP52_RS16490	COG0510	thiamine kinase activity
ITP52_RS16500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ITP52_RS16505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS16510	COG0281	malic enzyme
ITP52_RS16515	COG5584	Small secreted protein
ITP52_RS16520	COG1363	Peptidase, m42
ITP52_RS16535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS16540	COG4848	Belongs to the UPF0354 family
ITP52_RS16545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITP52_RS16550	COG1674	ftsk spoiiie
ITP52_RS16555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ITP52_RS16560	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ITP52_RS16565	COG4980	gas vesicle protein
ITP52_RS16570	COG3118	belongs to the thioredoxin family
ITP52_RS16575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ITP52_RS16575	COG1605	Chorismate mutase
ITP52_RS16580	COG1609	Transcriptional regulator
ITP52_RS16585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ITP52_RS16590	COG1360	Flagellar Motor Protein
ITP52_RS16595	COG0123	including yeast histone deacetylase and acetoin utilization protein
ITP52_RS16600	COG0517	IMP dehydrogenase activity
ITP52_RS16605	COG0454	-acetyltransferase
ITP52_RS16610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITP52_RS16615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ITP52_RS16620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ITP52_RS16625	COG2203	Gaf domain
ITP52_RS16625	COG2199	diguanylate cyclase activity
ITP52_RS16630	COG1956	GAF domain-containing protein
ITP52_RS16635	COG1309	transcriptional regulator
ITP52_RS16640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITP52_RS16645	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ITP52_RS16650	COG1114	Component of the transport system for branched-chain amino acids
ITP52_RS16655	COG1104	cysteine desulfurase activity
ITP52_RS16660	COG0301	tRNA thio-modification
ITP52_RS16670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ITP52_RS16675	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ITP52_RS16680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ITP52_RS16685	COG0616	signal peptide processing
ITP52_RS16690	COG1714	RDD family
ITP52_RS16700	COG3874	Sporulation protein YtfJ
ITP52_RS16705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ITP52_RS16710	COG0827	DNA restriction-modification system
ITP52_RS16720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ITP52_RS16725	COG0521	Mo-molybdopterin cofactor biosynthetic process
ITP52_RS16730	COG0137	argininosuccinate synthase activity
ITP52_RS16735	COG0165	Argininosuccinate lyase
ITP52_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS16745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ITP52_RS16750	COG0583	DNA-binding transcription factor activity
ITP52_RS16755	COG0454	-acetyltransferase
ITP52_RS16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS16765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS16770	COG0765	amino acid transport
ITP52_RS16775	COG0765	amino acid transport
ITP52_RS16780	COG1126	abc transporter atp-binding protein
ITP52_RS16785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS16790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ITP52_RS16795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ITP52_RS16800	COG0196	riboflavin kinase activity
ITP52_RS16805	COG1473	amidohydrolase
ITP52_RS16810	COG0730	response to heat
ITP52_RS16815	COG4109	DRTGG domain
ITP52_RS16825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ITP52_RS16845	COG0587	DNA-directed DNA polymerase activity
ITP52_RS16850	COG0281	malic enzyme
ITP52_RS16855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ITP52_RS16860	COG0825	malonyl-CoA metabolic process
ITP52_RS16865	COG0205	6-phosphofructokinase activity
ITP52_RS16870	COG0469	pyruvate kinase activity
ITP52_RS16875	COG3030	protein affecting phage T7 exclusion by the F plasmid
ITP52_RS16880	COG0628	permease
ITP52_RS16885	COG2707	UPF0756 membrane protein
ITP52_RS16890	COG0372	Belongs to the citrate synthase family
ITP52_RS16895	COG0538	isocitrate dehydrogenase activity
ITP52_RS16900	COG0039	L-malate dehydrogenase activity
ITP52_RS16905	COG0745	RESPONSE REGULATOR receiver
ITP52_RS16910	COG5002	protein histidine kinase activity
ITP52_RS16915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITP52_RS16915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITP52_RS16920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ITP52_RS16925	COG1971	Probably functions as a manganese efflux pump
ITP52_RS16930	COG0237	dephospho-CoA kinase activity
ITP52_RS16935	COG0656	L-ascorbic acid biosynthetic process
ITP52_RS16940	COG2814	Major facilitator Superfamily
ITP52_RS16945	COG1733	regulation of RNA biosynthetic process
ITP52_RS16950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ITP52_RS16955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ITP52_RS16960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ITP52_RS16965	COG3611	Membrane attachment protein
ITP52_RS16970	COG1484	DNA-dependent DNA replication
ITP52_RS16975	COG0398	Pfam SNARE associated Golgi protein
ITP52_RS16985	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ITP52_RS16990	COG1011	Hydrolase
ITP52_RS16995	COG3275	phosphorelay sensor kinase activity
ITP52_RS17000	COG3279	Response regulator of the LytR AlgR family
ITP52_RS17005	COG1380	Effector of murein hydrolase LrgA
ITP52_RS17010	COG1346	cytolysis
ITP52_RS17020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ITP52_RS17025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ITP52_RS17030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ITP52_RS17035	COG3326	Membrane
ITP52_RS17045	COG1363	Peptidase, m42
ITP52_RS17050	COG3507	Belongs to the glycosyl hydrolase 43 family
ITP52_RS17055	COG2160	L-arabinose isomerase activity
ITP52_RS17060	COG1069	ribulokinase activity
ITP52_RS17065	COG0235	Class ii aldolase
ITP52_RS17070	COG0647	UMP catabolic process
ITP52_RS17075	COG0371	Dehydrogenase
ITP52_RS17080	COG1653	transport
ITP52_RS17085	COG1175	transmembrane transport
ITP52_RS17090	COG0395	ABC-type sugar transport system, permease component
ITP52_RS17095	COG3534	alpha-L-arabinofuranosidase
ITP52_RS17100	COG1966	Carbon starvation protein
ITP52_RS17105	COG0346	lactoylglutathione lyase activity
ITP52_RS17110	COG0247	lactate metabolic process
ITP52_RS17115	COG0277	FAD linked oxidase domain protein
ITP52_RS17120	COG3835	regulator
ITP52_RS17130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ITP52_RS17140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ITP52_RS17145	COG0072	phenylalanine-tRNA ligase activity
ITP52_RS17145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ITP52_RS17150	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ITP52_RS17155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ITP52_RS17160	COG1286	toxin biosynthetic process
ITP52_RS17165	COG1796	DNA polymerase
ITP52_RS17165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ITP52_RS17170	COG1193	negative regulation of DNA recombination
ITP52_RS17175	COG3766	membrane
ITP52_RS17180	COG0318	PFAM AMP-dependent synthetase and ligase
ITP52_RS17185	COG1309	transcriptional regulator
ITP52_RS17190	COG1024	Enoyl-CoA hydratase
ITP52_RS17195	COG2086	electron transfer activity
ITP52_RS17200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ITP52_RS17205	COG3534	alpha-L-arabinofuranosidase
ITP52_RS17215	COG3118	belongs to the thioredoxin family
ITP52_RS17220	COG0322	excinuclease ABC activity
ITP52_RS17225	COG0527	aspartate kinase activity
ITP52_RS17230	COG1719	4-vinyl reductase, 4VR
ITP52_RS17235	COG2009	succinate dehydrogenase
ITP52_RS17240	COG1053	succinate dehydrogenase
ITP52_RS17245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ITP52_RS17250	COG0824	Thioesterase
ITP52_RS17255	COG2197	response regulator
ITP52_RS17260	COG1846	Transcriptional regulator
ITP52_RS17265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITP52_RS17270	COG5401	PFAM Sporulation and spore germination
ITP52_RS17275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ITP52_RS17280	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ITP52_RS17285	COG0622	Phosphoesterase
ITP52_RS17455	COG1780	Probably involved in ribonucleotide reductase function
ITP52_RS17465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS17475	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS17480	COG0756	dUTP diphosphatase activity
ITP52_RS17490	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ITP52_RS17495	COG1388	LysM domain
ITP52_RS17495	COG3584	3D domain protein
ITP52_RS17540	COG1793	dna ligase
ITP52_RS17565	COG3420	alginic acid biosynthetic process
ITP52_RS17565	COG5434	Belongs to the glycosyl hydrolase 28 family
ITP52_RS17570	COG4195	phage-related replication protein
ITP52_RS17580	COG1216	Glycosyl transferase, family 2
ITP52_RS17645	COG0740	serine-type endopeptidase activity
ITP52_RS17695	COG3953	SLT domain
ITP52_RS17695	COG5280	Phage tail tape measure protein TP901
ITP52_RS17755	COG1674	ftsk spoiiie
ITP52_RS17780	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ITP52_RS17785	COG0454	-acetyltransferase
ITP52_RS17795	COG0028	Belongs to the TPP enzyme family
ITP52_RS17800	COG0440	acetolactate synthase activity
ITP52_RS17805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ITP52_RS17810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ITP52_RS17815	COG0473	3-isopropylmalate dehydrogenase activity
ITP52_RS17820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ITP52_RS17825	COG0066	3-isopropylmalate dehydratase activity
ITP52_RS17830	COG1477	protein flavinylation
ITP52_RS17830	COG0457	Tetratricopeptide repeat
ITP52_RS17835	COG0544	peptidyl-prolyl cis-trans isomerase activity
ITP52_RS17840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ITP52_RS17845	COG0470	DNA polymerase III
ITP52_RS17845	COG1067	ATP-dependent peptidase activity
ITP52_RS17850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ITP52_RS17855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ITP52_RS17865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ITP52_RS17870	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITP52_RS17875	COG0181	hydroxymethylbilane synthase activity
ITP52_RS17880	COG1587	Uroporphyrinogen-III synthase
ITP52_RS17885	COG0113	porphobilinogen synthase activity
ITP52_RS17890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ITP52_RS17895	COG1388	LysM domain
ITP52_RS17900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ITP52_RS17910	COG0525	valine-tRNA ligase activity
ITP52_RS17915	COG0285	dihydrofolate synthase activity
ITP52_RS17920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ITP52_RS17930	COG0424	maF-like protein
ITP52_RS17935	COG2003	Belongs to the UPF0758 family
ITP52_RS17940	COG1077	Cell shape determining protein MreB Mrl
ITP52_RS17950	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ITP52_RS17955	COG0850	regulation of cytokinetic process
ITP52_RS17960	COG2894	cell division
ITP52_RS17965	COG0739	heme binding
ITP52_RS17970	COG1994	Peptidase M50
ITP52_RS17975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ITP52_RS17980	COG2868	ribosomal protein
ITP52_RS17985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ITP52_RS17995	COG3290	protein histidine kinase activity
ITP52_RS18000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ITP52_RS18005	COG4492	Belongs to the UPF0735 family
ITP52_RS18010	COG0077	Prephenate dehydratase
ITP52_RS18015	COG1827	regulation of RNA biosynthetic process
ITP52_RS18020	COG1104	cysteine desulfurase activity
ITP52_RS18025	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ITP52_RS18030	COG0157	Belongs to the NadC ModD family
ITP52_RS18035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ITP52_RS18040	COG1388	LysM domain
ITP52_RS18050	COG0217	transcriptional regulatory protein
ITP52_RS18055	COG1115	amino acid carrier protein
ITP52_RS18075	COG2112	serine threonine protein kinase
ITP52_RS18080	COG0673	inositol 2-dehydrogenase activity
ITP52_RS18085	COG2814	Major facilitator Superfamily
ITP52_RS18095	COG0632	four-way junction helicase activity
ITP52_RS18100	COG2255	four-way junction helicase activity
ITP52_RS18110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ITP52_RS18115	COG0343	queuine tRNA-ribosyltransferase activity
ITP52_RS18120	COG1862	Preprotein translocase
ITP52_RS18130	COG2323	membrane
ITP52_RS18135	COG2244	polysaccharide biosynthetic process
ITP52_RS18145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITP52_RS18145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ITP52_RS18150	COG0490	domain, Protein
ITP52_RS18155	COG5416	Lipopolysaccharide assembly protein A domain
ITP52_RS18160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ITP52_RS18160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITP52_RS18165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITP52_RS18170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ITP52_RS18175	COG1490	D-aminoacyl-tRNA deacylase activity
ITP52_RS18180	COG4991	sh3 domain protein
ITP52_RS18180	COG3103	Sh3 type 3 domain protein
ITP52_RS18180	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS18190	COG0124	histidyl-tRNA synthetase
ITP52_RS18195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ITP52_RS18205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ITP52_RS18210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ITP52_RS18215	COG1959	2 iron, 2 sulfur cluster binding
ITP52_RS18220	COG1104	cysteine desulfurase activity
ITP52_RS18225	COG0482	sulfurtransferase activity
ITP52_RS18230	COG0457	Tetratricopeptide repeat
ITP52_RS18235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ITP52_RS18240	COG3881	PFAM PRC-barrel domain
ITP52_RS18255	COG0765	amino acid transport
ITP52_RS18260	COG0765	amino acid transport
ITP52_RS18265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS18270	COG1126	abc transporter atp-binding protein
ITP52_RS18275	COG0628	permease
ITP52_RS18280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ITP52_RS18285	COG4472	Bacterial protein of unknown function (DUF965)
ITP52_RS18290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ITP52_RS18295	COG3906	Belongs to the UPF0473 family
ITP52_RS18300	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITP52_RS18305	COG4122	O-methyltransferase activity
ITP52_RS18310	COG0826	peptidase U32
ITP52_RS18315	COG0826	peptidase U32
ITP52_RS18320	COG0572	uridine kinase
ITP52_RS18325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ITP52_RS18330	COG0768	penicillin binding
ITP52_RS18345	COG2226	methyltransferase
ITP52_RS18350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ITP52_RS18355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ITP52_RS18360	COG0626	cystathionine gamma-synthase activity
ITP52_RS18370	COG2427	Protein of unknown function (DUF1641)
ITP52_RS18375	COG3383	formate dehydrogenase (NAD+) activity
ITP52_RS18380	COG5609	conserved protein (DUF2294)
ITP52_RS18385	COG2116	formate transmembrane transporter activity
ITP52_RS18400	COG2226	methyltransferase
ITP52_RS18405	COG1309	transcriptional regulator
ITP52_RS18410	COG2124	cytochrome p450
ITP52_RS18410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ITP52_RS18420	COG2755	lipolytic protein G-D-S-L family
ITP52_RS18420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ITP52_RS18430	COG1595	DNA-templated transcription, initiation
ITP52_RS18435	COG1378	Sugar-specific transcriptional regulator TrmB
ITP52_RS18440	COG1280	lysine exporter protein (LysE YggA)
ITP52_RS18445	COG1113	amino acid transport
ITP52_RS18455	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ITP52_RS18455	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITP52_RS18460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ITP52_RS18465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ITP52_RS18470	COG3715	PTS system
ITP52_RS18475	COG3716	PTS system mannose fructose sorbose family IID component
ITP52_RS18480	COG1621	beta-fructofuranosidase activity
ITP52_RS18485	COG0693	protein deglycase activity
ITP52_RS18490	COG1064	alcohol dehydrogenase
ITP52_RS18500	COG0789	Transcriptional regulator
ITP52_RS18505	COG5577	PFAM Coat F domain
ITP52_RS18515	COG1063	alcohol dehydrogenase
ITP52_RS18520	COG5577	PFAM Coat F domain
ITP52_RS18530	COG0346	lactoylglutathione lyase activity
ITP52_RS18540	COG4991	sh3 domain protein
ITP52_RS18545	COG4991	sh3 domain protein
ITP52_RS18550	COG0596	Alpha beta hydrolase
ITP52_RS18555	COG5566	PFAM Mor transcription activator
ITP52_RS18560	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS18565	COG2828	Protein conserved in bacteria
ITP52_RS18570	COG0583	DNA-binding transcription factor activity
ITP52_RS18575	COG2851	Citrate transporter
ITP52_RS18580	COG0667	Aldo Keto reductase
ITP52_RS18585	COG1595	DNA-templated transcription, initiation
ITP52_RS18590	COG3443	Belongs to the bacterial solute-binding protein 9 family
ITP52_RS18595	COG1846	Transcriptional regulator
ITP52_RS18600	COG0477	Major facilitator Superfamily
ITP52_RS18605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ITP52_RS18610	COG3958	Transketolase
ITP52_RS18615	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS18630	COG2186	Transcriptional regulator
ITP52_RS18640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ITP52_RS18645	COG2070	2-Nitropropane dioxygenase
ITP52_RS18655	COG2318	DinB family
ITP52_RS18670	COG1335	isochorismatase
ITP52_RS18685	COG2124	cytochrome p450
ITP52_RS18690	COG2732	(Barnase) inhibitor
ITP52_RS18695	COG1522	sequence-specific DNA binding
ITP52_RS18700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ITP52_RS18705	COG1687	branched-chain amino acid
ITP52_RS18710	COG1114	Component of the transport system for branched-chain amino acids
ITP52_RS18720	COG0583	DNA-binding transcription factor activity
ITP52_RS18725	COG1942	4-Oxalocrotonate Tautomerase
ITP52_RS18730	COG1230	cation diffusion facilitator family transporter
ITP52_RS18735	COG2072	flavoprotein involved in K transport
ITP52_RS18740	COG0583	DNA-binding transcription factor activity
ITP52_RS18745	COG0697	spore germination
ITP52_RS18755	COG1253	flavin adenine dinucleotide binding
ITP52_RS18760	COG0456	acetyltransferase
ITP52_RS18765	COG2814	Major facilitator Superfamily
ITP52_RS18770	COG0789	Transcriptional regulator
ITP52_RS18770	COG4978	Transcriptional regulator
ITP52_RS18780	COG0662	Cupin 2, conserved barrel domain protein
ITP52_RS18790	COG1937	Protein conserved in bacteria
ITP52_RS18795	COG2210	Belongs to the sulfur carrier protein TusA family
ITP52_RS18800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITP52_RS18800	COG0425	Belongs to the sulfur carrier protein TusA family
ITP52_RS18810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITP52_RS18810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS18815	COG0425	Belongs to the sulfur carrier protein TusA family
ITP52_RS18820	COG0730	response to heat
ITP52_RS18830	COG2249	NAD(P)H dehydrogenase (quinone) activity
ITP52_RS18835	COG0454	-acetyltransferase
ITP52_RS18845	COG2311	Membrane
ITP52_RS18850	COG0745	RESPONSE REGULATOR receiver
ITP52_RS18855	COG5002	protein histidine kinase activity
ITP52_RS18855	COG0642	Histidine kinase
ITP52_RS18860	COG3223	Belongs to the PsiE family
ITP52_RS18870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ITP52_RS18885	COG2856	Zn peptidase
ITP52_RS18890	COG0563	adenylate kinase activity
ITP52_RS18900	COG3620	sequence-specific DNA binding
ITP52_RS18905	COG1476	TRANSCRIPTIONal
ITP52_RS18935	COG5377	YqaJ viral recombinase family
ITP52_RS18940	COG3723	Recombinational DNA repair protein, rece pathway
ITP52_RS18945	COG3935	DnaD domain protein
ITP52_RS18950	COG1484	DNA-dependent DNA replication
ITP52_RS18960	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ITP52_RS18975	COG3677	Transposase
ITP52_RS18985	COG5484	DNA packaging
ITP52_RS18990	COG1783	phage Terminase large subunit
ITP52_RS18995	COG5518	Phage portal protein
ITP52_RS19000	COG2369	cell adhesion
ITP52_RS19010	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ITP52_RS19015	COG4653	Phage capsid family
ITP52_RS19080	COG3953	SLT domain
ITP52_RS19080	COG5280	Phage tail tape measure protein TP901
ITP52_RS19085	COG1652	LysM domain
ITP52_RS19090	COG4193	domain, Protein
ITP52_RS19100	COG3628	GPW Gp25 family protein
ITP52_RS19105	COG3299	homolog of phage Mu protein gp47
ITP52_RS19110	COG3778	Protein conserved in bacteria
ITP52_RS19140	COG4824	toxin secretion phage lysis holin
ITP52_RS19145	COG5632	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS19145	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS19170	COG5444	nuclease activity
ITP52_RS19185	COG0457	Tetratricopeptide repeat
ITP52_RS19190	COG3403	YqcI/YcgG family
ITP52_RS19195	COG0640	Transcriptional regulator
ITP52_RS19200	COG0346	lactoylglutathione lyase activity
ITP52_RS19205	COG0798	PFAM Bile acid sodium symporter
ITP52_RS19210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ITP52_RS19215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ITP52_RS19225	COG3209	COG3209 Rhs family protein
ITP52_RS19235	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ITP52_RS19240	COG0398	Pfam SNARE associated Golgi protein
ITP52_RS19245	COG5632	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS19245	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS19250	COG2755	lipolytic protein G-D-S-L family
ITP52_RS19260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ITP52_RS19265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ITP52_RS19270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ITP52_RS19275	COG1534	Rna-binding protein
ITP52_RS19280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ITP52_RS19285	COG1713	HD superfamily hydrolase involved in NAD metabolism
ITP52_RS19290	COG0799	negative regulation of ribosome biogenesis
ITP52_RS19295	COG2226	methyltransferase
ITP52_RS19300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITP52_RS19305	COG1596	polysaccharide export
ITP52_RS19305	COG1555	photosystem II stabilization
ITP52_RS19310	COG2131	deaminase
ITP52_RS19315	COG2333	competence protein COMEC
ITP52_RS19315	COG0658	competence protein
ITP52_RS19330	COG1466	dna polymerase III delta subunit
ITP52_RS19335	COG0268	Binds directly to 16S ribosomal RNA
ITP52_RS19340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ITP52_RS19345	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS19355	COG0481	GTPase activity
ITP52_RS19360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ITP52_RS19365	COG1420	regulation of RNA biosynthetic process
ITP52_RS19370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ITP52_RS19375	COG0443	Heat shock 70 kDa protein
ITP52_RS19380	COG0484	heat shock protein binding
ITP52_RS19385	COG2264	protein methyltransferase activity
ITP52_RS19390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ITP52_RS19395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ITP52_RS19400	COG1283	sodium-dependent phosphate transmembrane transporter activity
ITP52_RS19410	COG1610	YqeY-like protein
ITP52_RS19415	COG1030	water channel activity
ITP52_RS19420	COG4864	UPF0365 protein
ITP52_RS19435	COG0561	phosphatase activity
ITP52_RS19440	COG1702	phosphate starvation-inducible protein PhoH
ITP52_RS19445	COG1480	7TM receptor with intracellular HD hydrolase
ITP52_RS19450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ITP52_RS19455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ITP52_RS19460	COG0295	cytidine deaminase activity
ITP52_RS19465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ITP52_RS19475	COG1381	Involved in DNA repair and RecF pathway recombination
ITP52_RS19480	COG0752	glycyl-tRNA synthetase alpha subunit
ITP52_RS19485	COG0751	glycine-tRNA ligase activity
ITP52_RS19490	COG0517	IMP dehydrogenase activity
ITP52_RS19495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ITP52_RS19500	COG1671	Belongs to the UPF0178 family
ITP52_RS19505	COG0358	DNA primase activity
ITP52_RS19510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ITP52_RS19515	COG2010	Cytochrome c
ITP52_RS19520	COG2384	SAM-dependent methyltransferase
ITP52_RS19525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ITP52_RS19530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ITP52_RS19540	COG0513	Belongs to the DEAD box helicase family
ITP52_RS19545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ITP52_RS19555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS19560	COG0735	belongs to the Fur family
ITP52_RS19565	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ITP52_RS19570	COG4709	membrane
ITP52_RS19575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ITP52_RS19580	COG1388	LysM domain
ITP52_RS19585	COG5521	maltodextrose utilization protein MalA
ITP52_RS19590	COG2839	Protein conserved in bacteria
ITP52_RS19595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ITP52_RS19600	COG0477	Major facilitator Superfamily
ITP52_RS19605	COG0768	penicillin binding
ITP52_RS19610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ITP52_RS19615	COG0573	inorganic phosphate transmembrane transporter activity
ITP52_RS19620	COG0581	inorganic phosphate transmembrane transporter activity
ITP52_RS19625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITP52_RS19630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ITP52_RS19635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ITP52_RS19650	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS19660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ITP52_RS19670	COG0457	Tetratricopeptide repeat
ITP52_RS19670	COG0705	Rhomboid family
ITP52_RS19675	COG4483	Protein conserved in bacteria
ITP52_RS19680	COG1940	carbohydrate kinase activity
ITP52_RS19685	COG1368	sulfuric ester hydrolase activity
ITP52_RS19690	COG2866	Carboxypeptidase
ITP52_RS19700	COG0011	TIGRFAM Protein of
ITP52_RS19710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS19720	COG1393	Belongs to the ArsC family
ITP52_RS19730	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS19735	COG1253	flavin adenine dinucleotide binding
ITP52_RS19740	COG0598	Magnesium transport protein CorA
ITP52_RS19745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ITP52_RS19750	COG1459	type II secretion system
ITP52_RS19755	COG4537	Required for transformation and DNA binding
ITP52_RS19760	COG4970	Tfp pilus assembly protein FimT
ITP52_RS19770	COG4940	Competence protein ComGF
ITP52_RS19795	COG0681	Belongs to the peptidase S26 family
ITP52_RS19805	COG1396	sequence-specific DNA binding
ITP52_RS19820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ITP52_RS19825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ITP52_RS19830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ITP52_RS19835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ITP52_RS19840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ITP52_RS19845	COG0095	Lipoate-protein ligase
ITP52_RS19850	COG1321	iron dependent repressor
ITP52_RS19855	COG1752	Esterase of the alpha-beta hydrolase superfamily
ITP52_RS19865	COG3872	metal-dependent enzyme
ITP52_RS19875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ITP52_RS19880	COG0006	proline dipeptidase activity
ITP52_RS19885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ITP52_RS19895	COG3854	ATPases associated with a variety of cellular activities
ITP52_RS19935	COG0511	ligase activity, forming carbon-carbon bonds
ITP52_RS19940	COG0439	Biotin carboxylase
ITP52_RS19945	COG1302	Protein conserved in bacteria
ITP52_RS19950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ITP52_RS19955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ITP52_RS19960	COG1570	exodeoxyribonuclease VII activity
ITP52_RS19965	COG1722	exodeoxyribonuclease VII activity
ITP52_RS19970	COG0142	geranyltranstransferase activity
ITP52_RS19975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ITP52_RS19980	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ITP52_RS19985	COG1438	arginine binding
ITP52_RS19990	COG0497	DNA recombination
ITP52_RS19995	COG0750	zinc metalloprotease
ITP52_RS20000	COG0745	RESPONSE REGULATOR receiver
ITP52_RS20005	COG1902	pentaerythritol trinitrate reductase activity
ITP52_RS20020	COG0860	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS20025	COG0584	glycerophosphoryl diester phosphodiesterase
ITP52_RS20035	COG1250	3-hydroxyacyl-CoA dehydrogenase
ITP52_RS20040	COG1960	acyl-CoA dehydrogenase activity
ITP52_RS20045	COG0372	Belongs to the citrate synthase family
ITP52_RS20050	COG2079	MmgE PrpD family protein
ITP52_RS20055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ITP52_RS20065	COG3290	protein histidine kinase activity
ITP52_RS20065	COG3829	transcription factor binding
ITP52_RS20070	COG0280	phosphate acetyltransferase
ITP52_RS20075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ITP52_RS20080	COG3426	butyrate kinase activity
ITP52_RS20085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ITP52_RS20090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ITP52_RS20095	COG0022	dehydrogenase e1 component
ITP52_RS20100	COG0508	dehydrogenase complex catalyzes the overall conversion of
ITP52_RS20105	COG0789	Transcriptional regulator
ITP52_RS20105	COG4978	Transcriptional regulator
ITP52_RS20110	COG2814	Major facilitator Superfamily
ITP52_RS20115	COG1597	lipid kinase activity
ITP52_RS20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ITP52_RS20130	COG0765	amino acid transport
ITP52_RS20135	COG1126	abc transporter atp-binding protein
ITP52_RS20140	COG4129	membrane
ITP52_RS20145	COG1376	ErfK ybiS ycfS ynhG family protein
ITP52_RS20155	COG0346	lactoylglutathione lyase activity
ITP52_RS20160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ITP52_RS20165	COG2195	Cleaves the N-terminal amino acid of tripeptides
ITP52_RS20170	COG3361	conserved protein (COG2071)
ITP52_RS20175	COG0706	membrane insertase activity
ITP52_RS20185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITP52_RS20190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ITP52_RS20195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ITP52_RS20200	COG1234	tRNA 3'-trailer cleavage
ITP52_RS20210	COG0596	Alpha beta hydrolase
ITP52_RS20215	COG1902	pentaerythritol trinitrate reductase activity
ITP52_RS20220	COG4187	Peptidase family M20/M25/M40
ITP52_RS20225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ITP52_RS20230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ITP52_RS20235	COG0300	oxidoreductase activity
ITP52_RS20240	COG3048	D-serine ammonia-lyase activity
ITP52_RS20245	COG1072	(Pantothenic acid kinase))
ITP52_RS20250	COG0346	lactoylglutathione lyase activity
ITP52_RS20260	COG2211	Major facilitator Superfamily
ITP52_RS20270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITP52_RS20280	COG0456	acetyltransferase
ITP52_RS20285	COG2329	Antibiotic biosynthesis monooxygenase
ITP52_RS20290	COG0456	acetyltransferase
ITP52_RS20290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ITP52_RS20295	COG4918	Iron-sulphur cluster biosynthesis
ITP52_RS20305	COG1073	alpha beta
ITP52_RS20315	COG0667	Aldo Keto reductase
ITP52_RS20325	COG0494	nUDIX hydrolase
ITP52_RS20330	COG1379	DNA repair
ITP52_RS20335	COG1396	sequence-specific DNA binding
ITP52_RS20340	COG0252	asparaginase activity
ITP52_RS20345	COG1027	Aspartate ammonia-lyase
ITP52_RS20350	COG1757	Na H antiporter
ITP52_RS20355	COG0281	malic enzyme
ITP52_RS20365	COG1300	Membrane
ITP52_RS20370	COG0735	belongs to the Fur family
ITP52_RS20380	COG4974	Belongs to the 'phage' integrase family
ITP52_RS20385	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ITP52_RS20390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ITP52_RS20395	COG1686	Belongs to the peptidase S11 family
ITP52_RS20400	COG1366	Belongs to the anti-sigma-factor antagonist family
ITP52_RS20405	COG2172	sigma factor antagonist activity
ITP52_RS20410	COG1191	sigma factor activity
ITP52_RS20430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ITP52_RS20445	COG0697	spore germination
ITP52_RS20450	COG0019	diaminopimelate decarboxylase activity
ITP52_RS20455	COG4086	secreted protein
ITP52_RS20460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ITP52_RS20475	COG0681	Belongs to the peptidase S26 family
ITP52_RS20485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITP52_RS20485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ITP52_RS20490	COG0307	riboflavin synthase, alpha
ITP52_RS20495	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITP52_RS20495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ITP52_RS20500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ITP52_RS20505	COG0456	acetyltransferase
ITP52_RS20510	COG1547	Domain of unknown function (DUF309)
ITP52_RS20515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ITP52_RS20520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ITP52_RS20530	COG1686	Belongs to the peptidase S11 family
ITP52_RS20535	COG2715	membrane protein required for spore maturation
ITP52_RS20540	COG0700	Nucleoside recognition
ITP52_RS20545	COG1187	pseudouridine synthase activity
ITP52_RS20550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS20555	COG1333	cytochrome c biogenesis protein
ITP52_RS20560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ITP52_RS20565	COG0745	RESPONSE REGULATOR receiver
ITP52_RS20570	COG5002	protein histidine kinase activity
ITP52_RS20575	COG1595	DNA-templated transcription, initiation
ITP52_RS20585	COG0710	3-dehydroquinate dehydratase activity
ITP52_RS20590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ITP52_RS20595	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ITP52_RS20600	COG1141	Ferredoxin
ITP52_RS20605	COG4955	Helix-turn-helix domain
ITP52_RS20610	COG0514	ATP-dependent DNA helicase (RecQ)
ITP52_RS20615	COG1266	CAAX protease self-immunity
ITP52_RS20620	COG1388	LysM domain
ITP52_RS20630	COG1408	metallophosphoesterase
ITP52_RS20635	COG4862	establishment of competence for transformation
ITP52_RS20640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ITP52_RS20645	COG0492	ferredoxin-NADP+ reductase activity
ITP52_RS20650	COG2339	peptidase activity
ITP52_RS20655	COG3773	Cell wall hydrolase
ITP52_RS20655	COG3409	Peptidoglycan-binding domain 1 protein
ITP52_RS20660	COG2959	enzyme of heme biosynthesis
ITP52_RS20665	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ITP52_RS20675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ITP52_RS20680	COG0539	negative regulation of cytoplasmic translation
ITP52_RS20685	COG1304	FMN binding
ITP52_RS20710	COG1160	GTP binding
ITP52_RS20715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ITP52_RS20730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ITP52_RS20735	COG0776	regulation of translation
ITP52_RS20740	COG0302	gtp cyclohydrolase
ITP52_RS20750	COG0142	geranyltranstransferase activity
ITP52_RS20755	COG2226	methyltransferase
ITP52_RS20760	COG0142	geranyltranstransferase activity
ITP52_RS20765	COG0105	UTP biosynthetic process
ITP52_RS20770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ITP52_RS20775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ITP52_RS20780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ITP52_RS20785	COG4401	Chorismate mutase type I
ITP52_RS20790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ITP52_RS20795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ITP52_RS20805	COG0135	phosphoribosylanthranilate isomerase activity
ITP52_RS20810	COG0133	tryptophan synthase activity
ITP52_RS20820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ITP52_RS20825	COG0287	Prephenate dehydrogenase
ITP52_RS20830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ITP52_RS20835	COG0457	Tetratricopeptide repeat
ITP52_RS20840	COG5582	Belongs to the UPF0302 family
ITP52_RS20850	COG0723	plastoquinol--plastocyanin reductase activity
ITP52_RS20855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITP52_RS20860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ITP52_RS20860	COG2010	Cytochrome c
ITP52_RS20865	COG4347	Protein of unknown function (DUF1405)
ITP52_RS20875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ITP52_RS20880	COG1694	Mazg nucleotide pyrophosphohydrolase
ITP52_RS20885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ITP52_RS20890	COG1803	Methylglyoxal synthase
ITP52_RS20895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ITP52_RS20900	COG0438	transferase activity, transferring glycosyl groups
ITP52_RS20905	COG0617	tRNA 3'-terminal CCA addition
ITP52_RS20910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ITP52_RS20910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ITP52_RS20915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ITP52_RS20920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ITP52_RS20925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ITP52_RS20930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ITP52_RS20930	COG1199	ATP-dependent helicase activity
ITP52_RS20940	COG5353	protein conserved in bacteria
ITP52_RS20945	COG0436	Aminotransferase
ITP52_RS20950	COG0017	Asparaginyl-tRNA synthetase
ITP52_RS20955	COG3935	DnaD domain protein
ITP52_RS20960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ITP52_RS20970	COG4499	WXG100 protein secretion system (Wss), protein YukC
ITP52_RS20970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ITP52_RS20975	COG3331	DNA recombination
ITP52_RS21010	COG0071	Belongs to the small heat shock protein (HSP20) family
ITP52_RS21015	COG2190	(PTS) system
ITP52_RS21020	COG1205	dead DEAH box helicase
ITP52_RS21020	COG1111	helicase
ITP52_RS21025	COG3359	exonuclease
ITP52_RS21040	COG4474	Belongs to the UPF0398 family
ITP52_RS21055	COG0116	Belongs to the methyltransferase superfamily
ITP52_RS21070	COG1199	ATP-dependent helicase activity
ITP52_RS21075	COG1028	Short-chain dehydrogenase reductase Sdr
ITP52_RS21080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ITP52_RS21085	COG1609	Transcriptional regulator
ITP52_RS21090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ITP52_RS21095	COG0800	Aldolase
ITP52_RS21105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ITP52_RS21110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ITP52_RS21115	COG2233	PERMEase
ITP52_RS21120	COG3424	synthase
ITP52_RS21125	COG1755	Isoprenylcysteine carboxyl methyltransferase
ITP52_RS21135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ITP52_RS21150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ITP52_RS21160	COG0328	RNA-DNA hybrid ribonuclease activity
ITP52_RS21165	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ITP52_RS21170	COG0328	RNA-DNA hybrid ribonuclease activity
ITP52_RS21190	COG1278	Cold shock
ITP52_RS21200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ITP52_RS21205	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ITP52_RS21210	COG0386	Belongs to the glutathione peroxidase family
ITP52_RS21215	COG1418	mRNA catabolic process
ITP52_RS21220	COG1413	lyase activity
ITP52_RS21225	COG0129	dihydroxy-acid dehydratase activity
ITP52_RS21235	COG2521	methyltransferase
ITP52_RS21235	COG2136	Putative SAM-dependent methyltransferase
ITP52_RS21245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ITP52_RS21250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITP52_RS21255	COG0204	Acyl-transferase
ITP52_RS21260	COG1272	protein, Hemolysin III
ITP52_RS21265	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ITP52_RS21270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ITP52_RS21280	COG1999	signal sequence binding
ITP52_RS21285	COG2755	lipolytic protein G-D-S-L family
ITP52_RS21290	COG4698	Protein conserved in bacteria
ITP52_RS21330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ITP52_RS21365	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ITP52_RS21370	COG0756	dUTP diphosphatase activity
ITP52_RS21375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ITP52_RS21395	COG1372	Participates in initiation and elongation during chromosome replication
ITP52_RS21395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS21400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ITP52_RS21400	COG1372	Participates in initiation and elongation during chromosome replication
ITP52_RS21405	COG1780	Probably involved in ribonucleotide reductase function
ITP52_RS21490	COG0270	DNA (cytosine-5-)-methyltransferase activity
ITP52_RS21505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ITP52_RS21530	COG3584	3D domain protein
ITP52_RS21535	COG0587	DNA-directed DNA polymerase activity
ITP52_RS21540	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ITP52_RS21545	COG0358	DNA primase activity
ITP52_RS21550	COG0305	Participates in initiation and elongation during chromosome replication
ITP52_RS21560	COG2887	Belongs to the helicase family. UvrD subfamily
ITP52_RS21595	COG2135	peptidase activity
ITP52_RS21600	COG1793	dna ligase
ITP52_RS21640	COG1388	LysM domain
ITP52_RS21705	COG3655	Transcriptional regulator
ITP52_RS21720	COG0582	viral genome integration into host DNA
ITP52_RS21780	COG3655	Transcriptional regulator
ITP52_RS21855	COG0776	regulation of translation
ITP52_RS21895	COG4373	Mu-like prophage FluMu protein gp28
ITP52_RS21995	COG0582	viral genome integration into host DNA
ITP52_RS22015	COG1196	nuclear chromosome segregation
ITP52_RS22015	COG0739	heme binding
ITP52_RS22015	COG0741	lytic transglycosylase activity
ITP52_RS22025	COG2433	Pfam Transposase IS66
ITP52_RS22035	COG5434	Belongs to the glycosyl hydrolase 28 family
ITP52_RS22035	COG4632	Exopolysaccharide biosynthesis protein
ITP52_RS22040	COG5632	N-Acetylmuramoyl-L-alanine amidase
ITP52_RS22065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ITP52_RS22095	COG5444	nuclease activity
ITP52_RS22100	COG4282	regulation of fungal-type cell wall biogenesis
ITP52_RS22110	COG1525	nuclease