locus-tag	class	description
HWV68_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWV68_RS00010	COG0592	DNA-directed DNA polymerase activity
HWV68_RS00015	COG2501	S4 domain
HWV68_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HWV68_RS00030	COG0187	DNA topoisomerase II activity
HWV68_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV68_RS00070	COG0517	IMP dehydrogenase activity
HWV68_RS00070	COG0516	GMP reductase activity
HWV68_RS00075	COG1686	Belongs to the peptidase S11 family
HWV68_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HWV68_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HWV68_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HWV68_RS00100	COG1428	Deoxynucleoside kinase
HWV68_RS00105	COG1428	Deoxynucleoside kinase
HWV68_RS00110	COG3858	chitin binding
HWV68_RS00110	COG1388	LysM domain
HWV68_RS00115	COG1335	isochorismatase
HWV68_RS00120	COG0590	tRNA wobble adenosine to inosine editing
HWV68_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWV68_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWV68_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWV68_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HWV68_RS00190	COG3853	Toxic anion resistance protein (TelA)
HWV68_RS00195	COG1982	Orn Lys Arg decarboxylase major
HWV68_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWV68_RS00205	COG3870	Protein conserved in bacteria
HWV68_RS00210	COG1728	Protein conserved in bacteria
HWV68_RS00215	COG0470	DNA polymerase III
HWV68_RS00220	COG1774	PSP1 C-terminal conserved region
HWV68_RS00225	COG4467	Involved in initiation control of chromosome replication
HWV68_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HWV68_RS00235	COG2827	Endonuclease containing a URI domain
HWV68_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HWV68_RS00245	COG2002	toxin-antitoxin pair type II binding
HWV68_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_RS00255	COG0084	hydrolase, TatD family'
HWV68_RS00260	COG3583	domain protein
HWV68_RS00260	COG3584	3D domain protein
HWV68_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWV68_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWV68_RS00280	COG4466	Protein conserved in bacteria
HWV68_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HWV68_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_RS00300	COG0251	oxidation-reduction process
HWV68_RS00305	COG2088	sporulation resulting in formation of a cellular spore
HWV68_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWV68_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWV68_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HWV68_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
HWV68_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWV68_RS00340	COG2002	toxin-antitoxin pair type II binding
HWV68_RS00345	COG2244	polysaccharide biosynthetic process
HWV68_RS00350	COG3956	TIGRFAM MazG family protein
HWV68_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWV68_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWV68_RS00375	COG1098	S1 RNA binding domain
HWV68_RS00390	COG2208	phosphoserine phosphatase activity
HWV68_RS00395	COG2304	oxidoreductase activity
HWV68_RS00400	COG0515	serine threonine protein kinase
HWV68_RS00405	COG0037	tRNA processing
HWV68_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWV68_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HWV68_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HWV68_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWV68_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWV68_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
HWV68_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWV68_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWV68_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWV68_RS00470	COG1396	sequence-specific DNA binding
HWV68_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWV68_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HWV68_RS00560	COG4463	regulation of RNA biosynthetic process
HWV68_RS00565	COG3880	PFAM UvrB UvrC protein
HWV68_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HWV68_RS00575	COG0542	response to heat
HWV68_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HWV68_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HWV68_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
HWV68_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HWV68_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HWV68_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWV68_RS00610	COG1045	serine acetyltransferase
HWV68_RS00615	COG0215	cysteine-tRNA ligase activity
HWV68_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HWV68_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWV68_RS00630	COG3688	RNA-binding protein containing a PIN domain
HWV68_RS00635	COG1595	DNA-templated transcription, initiation
HWV68_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV68_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
HWV68_RS00660	COG0081	regulation of translation
HWV68_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HWV68_RS00675	COG2813	Specifically methylates the guanine in position
HWV68_RS00680	COG0085	RNA polymerase activity
HWV68_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HWV68_RS00690	COG1358	cellular component organization or biogenesis
HWV68_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HWV68_RS00700	COG0049	tRNA binding
HWV68_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWV68_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWV68_RS00715	COG0596	Alpha beta hydrolase
HWV68_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWV68_RS00730	COG0088	Forms part of the polypeptide exit tunnel
HWV68_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWV68_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HWV68_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HWV68_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HWV68_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HWV68_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWV68_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HWV68_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HWV68_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HWV68_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWV68_RS00820	COG0200	Binds to the 23S rRNA
HWV68_RS00825	COG0201	protein transport
HWV68_RS00830	COG0563	adenylate kinase activity
HWV68_RS00835	COG0024	Methionine aminopeptidase
HWV68_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWV68_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWV68_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HWV68_RS00865	COG0202	RNA polymerase activity
HWV68_RS00870	COG0203	ribosomal protein L17
HWV68_RS00875	COG1122	ATPase activity
HWV68_RS00880	COG1122	ATPase activity
HWV68_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWV68_RS00890	COG0101	tRNA pseudouridine synthase activity
HWV68_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HWV68_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWV68_RS00905	COG2226	methyltransferase
HWV68_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS00920	COG0489	protein tyrosine kinase activity
HWV68_RS00930	COG2194	sulfuric ester hydrolase activity
HWV68_RS00935	COG0726	polysaccharide deacetylase
HWV68_RS01015	COG0659	secondary active sulfate transmembrane transporter activity
HWV68_RS01020	COG0385	Bile acid
HWV68_RS01025	COG2819	hydrolase of the alpha beta superfamily
HWV68_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS01045	COG2207	Transcriptional regulator
HWV68_RS01050	COG3876	Protein conserved in bacteria
HWV68_RS01055	COG1472	Belongs to the glycosyl hydrolase 3 family
HWV68_RS01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_RS01065	COG1263	PTS System
HWV68_RS01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS01070	COG1737	Transcriptional regulator
HWV68_RS01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HWV68_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS01085	COG1683	Conserved Protein
HWV68_RS01115	COG1595	DNA-templated transcription, initiation
HWV68_RS01120	COG5662	AntiSigma factor
HWV68_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWV68_RS01130	COG4856	YbbR-like protein
HWV68_RS01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWV68_RS01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWV68_RS01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWV68_RS01155	COG2169	Transcriptional regulator
HWV68_RS01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWV68_RS01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWV68_RS01170	COG3002	Belongs to the UPF0753 family
HWV68_RS01175	COG0288	reversible hydration of carbon dioxide
HWV68_RS01185	COG5609	conserved protein (DUF2294)
HWV68_RS01190	COG0640	Transcriptional regulator
HWV68_RS01195	COG2814	Major facilitator Superfamily
HWV68_RS01210	COG0535	radical SAM domain protein
HWV68_RS01215	COG1266	CAAX protease self-immunity
HWV68_RS01220	COG1131	(ABC) transporter
HWV68_RS01230	COG1413	lyase activity
HWV68_RS01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS01240	COG0596	Alpha beta hydrolase
HWV68_RS01245	COG0745	RESPONSE REGULATOR receiver
HWV68_RS01250	COG0642	Histidine kinase
HWV68_RS01260	COG0515	serine threonine protein kinase
HWV68_RS01275	COG1113	amino acid transport
HWV68_RS01290	COG2602	Beta-lactamase
HWV68_RS01295	COG2124	cytochrome p450
HWV68_RS01305	COG0531	amino acid
HWV68_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_RS01315	COG2271	Major facilitator Superfamily
HWV68_RS01325	COG1846	Transcriptional regulator
HWV68_RS01325	COG0456	acetyltransferase
HWV68_RS01330	COG2271	Major facilitator Superfamily
HWV68_RS01340	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS01345	COG0697	spore germination
HWV68_RS01350	COG2207	Transcriptional regulator
HWV68_RS01350	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HWV68_RS01360	COG3591	Belongs to the peptidase S1B family
HWV68_RS01370	COG0596	Alpha beta hydrolase
HWV68_RS01375	COG1183	phosphatidylcholine synthase activity
HWV68_RS01380	COG0586	Pfam SNARE associated Golgi protein
HWV68_RS01385	COG0688	phosphatidylethanolamine metabolic process
HWV68_RS01395	COG2312	Erythromycin esterase
HWV68_RS01400	COG2207	Transcriptional regulator
HWV68_RS01410	COG1301	dicarboxylic acid transport
HWV68_RS01415	COG1263	PTS System
HWV68_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS01415	COG2190	(PTS) system
HWV68_RS01420	COG0363	glucosamine-6-phosphate deaminase activity
HWV68_RS01425	COG2188	Transcriptional regulator
HWV68_RS01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_RS01440	COG0833	amino acid
HWV68_RS01445	COG2040	homocysteine
HWV68_RS01450	COG1115	amino acid carrier protein
HWV68_RS01455	COG2066	Belongs to the glutaminase family
HWV68_RS01460	COG4191	Histidine kinase
HWV68_RS01465	COG0784	Response regulator, receiver
HWV68_RS01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWV68_RS01475	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS01480	COG2271	Major facilitator Superfamily
HWV68_RS01485	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_RS01490	COG2186	Transcriptional regulator
HWV68_RS01495	COG2721	sulfolactate sulfo-lyase activity
HWV68_RS01500	COG3173	Aminoglycoside phosphotransferase
HWV68_RS01510	COG0697	spore germination
HWV68_RS01515	COG0745	RESPONSE REGULATOR receiver
HWV68_RS01520	COG2205	protein histidine kinase activity
HWV68_RS01525	COG1131	(ABC) transporter
HWV68_RS01545	COG3773	Cell wall hydrolase
HWV68_RS01550	COG2304	oxidoreductase activity
HWV68_RS01560	COG3540	Alkaline phosphatase
HWV68_RS01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_RS01570	COG0805	protein transport
HWV68_RS01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HWV68_RS01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWV68_RS01585	COG0477	Major facilitator Superfamily
HWV68_RS01590	COG1309	transcriptional regulator
HWV68_RS01595	COG0252	asparaginase activity
HWV68_RS01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWV68_RS01605	COG1714	RDD family
HWV68_RS01610	COG1405	negative regulation of cell septum assembly
HWV68_RS01610	COG3012	SEC-C Motif Domain Protein
HWV68_RS01615	COG3290	protein histidine kinase activity
HWV68_RS01620	COG3279	Response regulator of the LytR AlgR family
HWV68_RS01625	COG4555	ABC transporter
HWV68_RS01630	COG1668	transmembrane transport
HWV68_RS01635	COG0667	Aldo Keto reductase
HWV68_RS01650	COG1595	DNA-templated transcription, initiation
HWV68_RS01655	COG1595	DNA-templated transcription, initiation
HWV68_RS01660	COG1876	peptidase activity
HWV68_RS01665	COG0457	Tetratricopeptide repeat
HWV68_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS01675	COG0366	Alpha amylase catalytic
HWV68_RS01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWV68_RS01685	COG1121	(ABC) transporter
HWV68_RS01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_RS01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS01700	COG2310	stress, protein
HWV68_RS01705	COG2310	stress, protein
HWV68_RS01710	COG2310	stress, protein
HWV68_RS01715	COG0861	Integral membrane protein TerC family
HWV68_RS01725	COG3853	Toxic anion resistance protein (TelA)
HWV68_RS01730	COG0477	Major facilitator Superfamily
HWV68_RS01735	COG2814	Major facilitator Superfamily
HWV68_RS01740	COG0640	Transcriptional regulator
HWV68_RS01745	COG4175	Glycine betaine
HWV68_RS01745	COG0517	IMP dehydrogenase activity
HWV68_RS01750	COG4176	ABC-type proline glycine betaine transport system permease component
HWV68_RS01755	COG2113	Glycine betaine
HWV68_RS01760	COG1473	amidohydrolase
HWV68_RS01765	COG1288	antiporter activity
HWV68_RS01775	COG0366	Alpha amylase catalytic
HWV68_RS01780	COG0039	L-malate dehydrogenase activity
HWV68_RS01785	COG1620	l-lactate permease
HWV68_RS01790	COG2814	Major facilitator Superfamily
HWV68_RS01795	COG1846	Transcriptional regulator
HWV68_RS01800	COG1280	lysine exporter protein (LysE YggA)
HWV68_RS01805	COG3403	YqcI/YcgG family
HWV68_RS01810	COG1113	amino acid transport
HWV68_RS01815	COG3665	Urea carboxylase-associated protein
HWV68_RS01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWV68_RS01825	COG1660	Displays ATPase and GTPase activities
HWV68_RS01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWV68_RS01835	COG2226	methyltransferase
HWV68_RS01840	COG0583	DNA-binding transcription factor activity
HWV68_RS01845	COG3458	cephalosporin-C deacetylase activity
HWV68_RS01850	COG3541	Predicted nucleotidyltransferase
HWV68_RS01855	COG0506	proline dehydrogenase activity
HWV68_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_RS01870	COG2508	Transcriptional regulator
HWV68_RS01875	COG3689	TIGRFAM TIGR03943 family protein
HWV68_RS01880	COG0701	Predicted permease
HWV68_RS01885	COG2267	carboxylic ester hydrolase activity
HWV68_RS01890	COG0492	ferredoxin-NADP+ reductase activity
HWV68_RS01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWV68_RS01895	COG1587	Uroporphyrinogen-III synthase
HWV68_RS01900	COG2146	nitrite reductase [NAD(P)H] activity
HWV68_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_RS01910	COG0243	molybdopterin cofactor binding
HWV68_RS01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_RS01920	COG2223	nitrite transmembrane transporter activity
HWV68_RS01925	COG1469	GTP cyclohydrolase I activity
HWV68_RS01930	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_RS01940	COG0523	cobalamin synthesis protein
HWV68_RS01945	COG0765	amino acid transport
HWV68_RS01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS01960	COG1714	RDD family
HWV68_RS01970	COG2723	6-phospho-beta-galactosidase activity
HWV68_RS01980	COG3209	COG3209 Rhs family protein
HWV68_RS01985	COG0840	transmembrane signaling receptor activity
HWV68_RS01985	COG3290	protein histidine kinase activity
HWV68_RS01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWV68_RS01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HWV68_RS02000	COG1733	regulation of RNA biosynthetic process
HWV68_RS02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HWV68_RS02025	COG2814	Major facilitator Superfamily
HWV68_RS02035	COG0697	spore germination
HWV68_RS02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS02050	COG2364	Membrane
HWV68_RS02055	COG1126	abc transporter atp-binding protein
HWV68_RS02060	COG0765	amino acid transport
HWV68_RS02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS02070	COG0583	DNA-binding transcription factor activity
HWV68_RS02075	COG0163	prenyltransferase activity
HWV68_RS02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HWV68_RS02095	COG0596	Alpha beta hydrolase
HWV68_RS02100	COG3104	oligopeptide transport
HWV68_RS02105	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_RS02115	COG0697	spore germination
HWV68_RS02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWV68_RS02130	COG1136	(ABC) transporter
HWV68_RS02135	COG0577	efflux transmembrane transporter activity
HWV68_RS02140	COG0745	RESPONSE REGULATOR receiver
HWV68_RS02145	COG3850	Histidine kinase
HWV68_RS02145	COG5002	protein histidine kinase activity
HWV68_RS02150	COG0457	Tetratricopeptide repeat
HWV68_RS02170	COG0527	aspartate kinase activity
HWV68_RS02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS02180	COG4605	iron ion homeostasis
HWV68_RS02185	COG4604	ABC transporter, ATP-binding protein
HWV68_RS02190	COG4607	ABC-type enterochelin transport system periplasmic component
HWV68_RS02195	COG2814	Major facilitator Superfamily
HWV68_RS02200	COG1309	transcriptional regulator
HWV68_RS02205	COG0778	Nitroreductase
HWV68_RS02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWV68_RS02215	COG0640	Transcriptional regulator
HWV68_RS02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWV68_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS02235	COG4975	Glucose uptake
HWV68_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS02245	COG4549	nuclear export factor GLE1
HWV68_RS02250	COG2372	response to copper ion
HWV68_RS02250	COG1276	copper resistance
HWV68_RS02255	COG1349	DNA-binding transcription factor activity
HWV68_RS02265	COG2213	PTS system mannitol-specific
HWV68_RS02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS02275	COG0246	Mannitol dehydrogenase
HWV68_RS02280	COG0473	3-isopropylmalate dehydrogenase activity
HWV68_RS02285	COG0681	Belongs to the peptidase S26 family
HWV68_RS02290	COG0412	Dienelactone hydrolase
HWV68_RS02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV68_RS02305	COG0561	phosphatase activity
HWV68_RS02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWV68_RS02315	COG1914	H( )-stimulated, divalent metal cation uptake system
HWV68_RS02320	COG4336	lyase activity
HWV68_RS02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWV68_RS02330	COG1984	allophanate hydrolase subunit 2
HWV68_RS02335	COG1414	Transcriptional regulator
HWV68_RS02340	COG2755	lipolytic protein G-D-S-L family
HWV68_RS02350	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_RS02355	COG0768	penicillin binding
HWV68_RS02360	COG4989	oxidoreductase activity
HWV68_RS02365	COG3711	transcriptional antiterminator
HWV68_RS02370	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS02375	COG2226	methyltransferase
HWV68_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS02385	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS02395	COG3871	stress protein (general stress protein 26)
HWV68_RS02405	COG2814	Major facilitator Superfamily
HWV68_RS02410	COG1522	sequence-specific DNA binding
HWV68_RS02415	COG0551	DNA topoisomerase type I activity
HWV68_RS02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWV68_RS02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HWV68_RS02425	COG3706	GGDEF domain
HWV68_RS02430	COG5298	Protein conserved in bacteria
HWV68_RS02435	COG1215	transferase activity, transferring glycosyl groups
HWV68_RS02445	COG0531	amino acid
HWV68_RS02450	COG0494	nUDIX hydrolase
HWV68_RS02455	COG0028	Belongs to the TPP enzyme family
HWV68_RS02470	COG1914	H( )-stimulated, divalent metal cation uptake system
HWV68_RS02475	COG2261	transglycosylase associated protein
HWV68_RS02480	COG4876	unkown
HWV68_RS02485	COG2217	Heavy metal translocating P-type atpase
HWV68_RS02490	COG3729	General stress protein
HWV68_RS02495	COG0662	Cupin 2, conserved barrel domain protein
HWV68_RS02500	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_RS02505	COG3546	catalase activity
HWV68_RS02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HWV68_RS02515	COG3290	protein histidine kinase activity
HWV68_RS02520	COG4565	transcriptional regulatory protein
HWV68_RS02525	COG1301	dicarboxylic acid transport
HWV68_RS02530	COG0628	permease
HWV68_RS02535	COG1131	(ABC) transporter
HWV68_RS02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_RS02550	COG1960	acyl-CoA dehydrogenase activity
HWV68_RS02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
HWV68_RS02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWV68_RS02585	COG0513	Belongs to the DEAD box helicase family
HWV68_RS02590	COG3402	PFAM membrane-flanked domain
HWV68_RS02595	COG3428	Bacterial PH domain
HWV68_RS02600	COG0705	Rhomboid family
HWV68_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
HWV68_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWV68_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWV68_RS02620	COG0864	Transcriptional regulator
HWV68_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
HWV68_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS02640	COG2172	sigma factor antagonist activity
HWV68_RS02645	COG2208	phosphoserine phosphatase activity
HWV68_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS02655	COG2172	sigma factor antagonist activity
HWV68_RS02660	COG1191	sigma factor activity
HWV68_RS02665	COG2208	phosphoserine phosphatase activity
HWV68_RS02680	COG1673	EVE domain
HWV68_RS02685	COG1846	Transcriptional regulator
HWV68_RS02690	COG2183	response to ionizing radiation
HWV68_RS02700	COG3091	SprT-like family
HWV68_RS02740	COG0582	viral genome integration into host DNA
HWV68_RS02745	COG2856	Zn peptidase
HWV68_RS02750	COG1396	sequence-specific DNA binding
HWV68_RS02780	COG1674	ftsk spoiiie
HWV68_RS02785	COG2946	Replication initiation factor
HWV68_RS02820	COG0433	COG0433 Predicted ATPase
HWV68_RS02830	COG5644	endopeptidase inhibitor activity
HWV68_RS02835	COG0791	NLP P60 protein
HWV68_RS02835	COG0741	lytic transglycosylase activity
HWV68_RS02855	COG0457	Tetratricopeptide repeat
HWV68_RS02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS02875	COG1522	sequence-specific DNA binding
HWV68_RS02880	COG1522	sequence-specific DNA binding
HWV68_RS02885	COG1335	isochorismatase
HWV68_RS02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWV68_RS02895	COG2814	Major facilitator Superfamily
HWV68_RS02915	COG0693	protein deglycase activity
HWV68_RS02920	COG1278	Cold shock
HWV68_RS02925	COG1329	Transcriptional regulator
HWV68_RS02935	COG2207	Transcriptional regulator
HWV68_RS02935	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS02940	COG0697	spore germination
HWV68_RS02945	COG3708	Transcriptional regulator
HWV68_RS02945	COG2207	Transcriptional regulator
HWV68_RS02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS02955	COG0477	Major facilitator Superfamily
HWV68_RS02965	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HWV68_RS02975	COG0697	spore germination
HWV68_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS02985	COG2030	dehydratase
HWV68_RS02990	COG3545	Serine hydrolase
HWV68_RS02995	COG1733	regulation of RNA biosynthetic process
HWV68_RS03000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS03005	COG1733	regulation of RNA biosynthetic process
HWV68_RS03010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_RS03015	COG2814	Major facilitator Superfamily
HWV68_RS03020	COG1309	transcriptional regulator
HWV68_RS03025	COG0640	Transcriptional regulator
HWV68_RS03030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWV68_RS03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS03045	COG0697	spore germination
HWV68_RS03050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS03055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWV68_RS03060	COG0640	Transcriptional regulator
HWV68_RS03065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWV68_RS03080	COG4585	Histidine kinase
HWV68_RS03085	COG2197	response regulator
HWV68_RS03090	COG2409	Drug exporters of the RND superfamily
HWV68_RS03095	COG0596	Alpha beta hydrolase
HWV68_RS03100	COG1811	Na channel or pump
HWV68_RS03105	COG0789	Transcriptional regulator
HWV68_RS03105	COG4978	Transcriptional regulator
HWV68_RS03110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_RS03115	COG0778	Nitroreductase
HWV68_RS03120	COG0346	lactoylglutathione lyase activity
HWV68_RS03125	COG2259	Doxx family
HWV68_RS03130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS03145	COG2323	membrane
HWV68_RS03150	COG2323	membrane
HWV68_RS03155	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_RS03170	COG1309	transcriptional regulator
HWV68_RS03180	COG0456	acetyltransferase
HWV68_RS03190	COG1113	amino acid transport
HWV68_RS03195	COG2318	DinB family
HWV68_RS03200	COG1846	Transcriptional regulator
HWV68_RS03205	COG1033	growth of symbiont in host cell
HWV68_RS03205	COG2409	Drug exporters of the RND superfamily
HWV68_RS03210	COG0778	Nitroreductase
HWV68_RS03215	COG1846	Transcriptional regulator
HWV68_RS03220	COG2814	Major facilitator Superfamily
HWV68_RS03225	COG0730	response to heat
HWV68_RS03230	COG1802	Transcriptional regulator
HWV68_RS03235	COG3858	chitin binding
HWV68_RS03235	COG1388	LysM domain
HWV68_RS03240	COG1819	glycosyl
HWV68_RS03250	COG1785	Belongs to the alkaline phosphatase family
HWV68_RS03255	COG5646	InterPro IPR014922
HWV68_RS03265	COG0454	-acetyltransferase
HWV68_RS03270	COG1078	dGTPase activity
HWV68_RS03275	COG1388	LysM domain
HWV68_RS03280	COG2814	Major facilitator Superfamily
HWV68_RS03285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_RS03290	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWV68_RS03295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_RS03300	COG2723	6-phospho-beta-galactosidase activity
HWV68_RS03305	COG2188	Transcriptional regulator
HWV68_RS03310	COG1940	carbohydrate kinase activity
HWV68_RS03315	COG1482	cell wall glycoprotein biosynthetic process
HWV68_RS03320	COG4124	Belongs to the glycosyl hydrolase 26 family
HWV68_RS03365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWV68_RS03370	COG0802	atpase or kinase
HWV68_RS03375	COG1214	PFAM Peptidase M22, glycoprotease
HWV68_RS03380	COG0456	acetyltransferase
HWV68_RS03385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWV68_RS03390	COG0488	(ABC) transporter
HWV68_RS03395	COG0315	cyclic pyranopterin monophosphate synthase activity
HWV68_RS03400	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HWV68_RS03405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_RS03410	COG0805	protein transport
HWV68_RS03420	COG1266	CAAX protease self-immunity
HWV68_RS03430	COG0459	protein refolding
HWV68_RS03440	COG3378	Phage plasmid primase P4 family
HWV68_RS03455	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_RS03460	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_RS03480	COG1401	restriction endodeoxyribonuclease activity
HWV68_RS03500	COG0457	Tetratricopeptide repeat
HWV68_RS03505	COG1063	alcohol dehydrogenase
HWV68_RS03510	COG2211	Major facilitator Superfamily
HWV68_RS03515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_RS03520	COG1842	Phage shock protein A
HWV68_RS03525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWV68_RS03530	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWV68_RS03535	COG4260	virion core protein, lumpy skin disease virus
HWV68_RS03545	COG2814	Major facilitator Superfamily
HWV68_RS03550	COG1063	alcohol dehydrogenase
HWV68_RS03555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWV68_RS03560	COG0823	Involved in the tonB-independent uptake of proteins
HWV68_RS03575	COG2267	carboxylic ester hydrolase activity
HWV68_RS03585	COG2132	Multicopper oxidase
HWV68_RS03590	COG1113	amino acid transport
HWV68_RS03600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_RS03605	COG0714	Associated with various cellular activities
HWV68_RS03610	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HWV68_RS03615	COG1305	Transglutaminase-like
HWV68_RS03620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWV68_RS03620	COG0519	Catalyzes the synthesis of GMP from XMP
HWV68_RS03625	COG2252	PERMEase
HWV68_RS03630	COG3064	Membrane
HWV68_RS03640	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HWV68_RS03650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWV68_RS03655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWV68_RS03660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWV68_RS03665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWV68_RS03670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV68_RS03675	COG0047	phosphoribosylformylglycinamidine synthase activity
HWV68_RS03680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV68_RS03685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HWV68_RS03690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HWV68_RS03695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWV68_RS03700	COG0138	bifunctional purine biosynthesis protein purh
HWV68_RS03705	COG0151	Belongs to the GarS family
HWV68_RS03710	COG1522	sequence-specific DNA binding
HWV68_RS03715	COG0531	amino acid
HWV68_RS03725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWV68_RS03730	COG1470	cell adhesion involved in biofilm formation
HWV68_RS03735	COG4496	protein, YerC YecD
HWV68_RS03740	COG0069	glutamate synthase activity
HWV68_RS03745	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HWV68_RS03750	COG0210	DNA helicase
HWV68_RS03755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWV68_RS03760	COG4851	CamS sex pheromone cAM373 precursor
HWV68_RS03765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_RS03770	COG1285	pathogenesis
HWV68_RS03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_RS03780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV68_RS03785	COG0154	amidase activity
HWV68_RS03790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV68_RS03795	COG1309	transcriptional regulator
HWV68_RS03800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWV68_RS03805	COG1597	lipid kinase activity
HWV68_RS03810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWV68_RS03815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_RS03820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_RS03825	COG1002	Type II restriction enzyme, methylase subunits
HWV68_RS03830	COG1061	Type III restriction enzyme res subunit
HWV68_RS03835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWV68_RS03855	COG5444	nuclease activity
HWV68_RS03860	COG3391	amine dehydrogenase activity
HWV68_RS03865	COG0457	Tetratricopeptide repeat
HWV68_RS03875	COG0217	transcriptional regulatory protein
HWV68_RS03885	COG1309	transcriptional regulator
HWV68_RS03890	COG3631	Ketosteroid isomerase-related protein
HWV68_RS03895	COG0702	epimerase
HWV68_RS03910	COG3546	catalase activity
HWV68_RS03915	COG0454	-acetyltransferase
HWV68_RS03925	COG5578	integral membrane protein
HWV68_RS03930	COG2972	Histidine kinase
HWV68_RS03935	COG2207	Transcriptional regulator
HWV68_RS03935	COG4753	response regulator
HWV68_RS03940	COG1653	transport
HWV68_RS03945	COG1175	transmembrane transport
HWV68_RS03950	COG0395	ABC-type sugar transport system, permease component
HWV68_RS03955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HWV68_RS03960	COG2207	Transcriptional regulator
HWV68_RS03965	COG2755	lipolytic protein G-D-S-L family
HWV68_RS03975	COG5578	integral membrane protein
HWV68_RS03980	COG3401	FG-GAP repeat protein
HWV68_RS03985	COG3401	FG-GAP repeat protein
HWV68_RS03990	COG2755	lipolytic protein G-D-S-L family
HWV68_RS03995	COG1874	Beta-galactosidase
HWV68_RS04005	COG1653	transport
HWV68_RS04010	COG4209	transmembrane transport
HWV68_RS04015	COG0395	ABC-type sugar transport system, permease component
HWV68_RS04020	COG1486	melibiose metabolic process
HWV68_RS04025	COG2323	membrane
HWV68_RS04030	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_RS04035	COG0346	lactoylglutathione lyase activity
HWV68_RS04050	COG5583	Uncharacterized small protein (DUF2292)
HWV68_RS04055	COG0670	Belongs to the BI1 family
HWV68_RS04060	COG0697	spore germination
HWV68_RS04065	COG1846	Transcriptional regulator
HWV68_RS04070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV68_RS04080	COG2124	cytochrome p450
HWV68_RS04080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_RS04085	COG1368	sulfuric ester hydrolase activity
HWV68_RS04090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWV68_RS04095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_RS04100	COG1442	glycosyl transferase family 8
HWV68_RS04105	COG1216	Glycosyl transferase, family 2
HWV68_RS04110	COG1442	glycosyl transferase family 8
HWV68_RS04115	COG2223	nitrite transmembrane transporter activity
HWV68_RS04120	COG1011	Hydrolase
HWV68_RS04125	COG0531	amino acid
HWV68_RS04130	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS04135	COG0840	transmembrane signaling receptor activity
HWV68_RS04140	COG0488	(ABC) transporter
HWV68_RS04150	COG0789	Transcriptional regulator
HWV68_RS04155	COG2814	Major facilitator Superfamily
HWV68_RS04165	COG0488	(ABC) transporter
HWV68_RS04170	COG0513	Belongs to the DEAD box helicase family
HWV68_RS04175	COG0456	acetyltransferase
HWV68_RS04180	COG2130	NADP-dependent
HWV68_RS04185	COG2211	Major facilitator Superfamily
HWV68_RS04190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWV68_RS04195	COG1120	ATPase activity
HWV68_RS04200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS04205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS04210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWV68_RS04225	COG3866	Pectate lyase
HWV68_RS04230	COG0471	metal ion transport
HWV68_RS04235	COG3290	protein histidine kinase activity
HWV68_RS04240	COG4565	transcriptional regulatory protein
HWV68_RS04245	COG3181	Tripartite tricarboxylate transporter family receptor
HWV68_RS04250	COG2851	Citrate transporter
HWV68_RS04255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS04260	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HWV68_RS04265	COG1254	Belongs to the acylphosphatase family
HWV68_RS04270	COG2258	MOSC domain
HWV68_RS04290	COG0024	Methionine aminopeptidase
HWV68_RS04295	COG1263	PTS System
HWV68_RS04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS04300	COG1368	sulfuric ester hydrolase activity
HWV68_RS04315	COG1115	amino acid carrier protein
HWV68_RS04320	COG0531	amino acid
HWV68_RS04335	COG0697	spore germination
HWV68_RS04340	COG1263	PTS System
HWV68_RS04340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS04345	COG0366	Alpha amylase catalytic
HWV68_RS04350	COG2188	Transcriptional regulator
HWV68_RS04355	COG0778	Nitroreductase
HWV68_RS04360	COG0737	Belongs to the 5'-nucleotidase family
HWV68_RS04365	COG0693	protein deglycase activity
HWV68_RS04370	COG2814	Major facilitator Superfamily
HWV68_RS04375	COG4840	Belongs to the UPF0435 family
HWV68_RS04380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_RS04385	COG4980	gas vesicle protein
HWV68_RS04390	COG1295	ribonuclease BN
HWV68_RS04395	COG0477	Major facilitator Superfamily
HWV68_RS04400	COG0387	Pfam Sodium calcium exchanger
HWV68_RS04410	COG0668	transmembrane transport
HWV68_RS04415	COG0535	radical SAM domain protein
HWV68_RS04425	COG0726	polysaccharide deacetylase
HWV68_RS04430	COG2084	Dehydrogenase
HWV68_RS04435	COG0598	Magnesium transport protein CorA
HWV68_RS04440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWV68_RS04445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWV68_RS04455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWV68_RS04460	COG4637	Psort location Cytoplasmic, score
HWV68_RS04470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_RS04475	COG0022	dehydrogenase e1 component
HWV68_RS04480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_RS04485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_RS04490	COG3284	Transcriptional regulator
HWV68_RS04500	COG1742	UPF0060 membrane protein
HWV68_RS04525	COG4842	Belongs to the WXG100 family
HWV68_RS04530	COG1486	melibiose metabolic process
HWV68_RS04535	COG1737	Transcriptional regulator
HWV68_RS04540	COG1263	PTS System
HWV68_RS04540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS04545	COG1132	(ABC) transporter
HWV68_RS04550	COG1132	(ABC) transporter
HWV68_RS04555	COG2259	Doxx family
HWV68_RS04560	COG2514	catechol 2,3-dioxygenase activity
HWV68_RS04565	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS04565	COG4977	sequence-specific DNA binding
HWV68_RS04570	COG2814	Major facilitator Superfamily
HWV68_RS04575	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_RS04580	COG0673	inositol 2-dehydrogenase activity
HWV68_RS04585	COG4585	Histidine kinase
HWV68_RS04590	COG2197	response regulator
HWV68_RS04595	COG1131	(ABC) transporter
HWV68_RS04600	COG1511	domain protein
HWV68_RS04600	COG0842	Transport permease protein
HWV68_RS04605	COG0842	Transport permease protein
HWV68_RS04610	COG1695	Transcriptional regulator
HWV68_RS04615	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWV68_RS04620	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HWV68_RS04625	COG1309	transcriptional regulator
HWV68_RS04630	COG2814	Major facilitator Superfamily
HWV68_RS04635	COG2318	DinB family
HWV68_RS04640	COG2814	Major facilitator Superfamily
HWV68_RS04645	COG1846	Transcriptional regulator
HWV68_RS04650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HWV68_RS04650	COG0392	lysyltransferase activity
HWV68_RS04655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS04665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS04670	COG0384	phenazine biosynthesis protein PhzF
HWV68_RS04675	COG0778	Nitroreductase
HWV68_RS04690	COG1090	epimerase
HWV68_RS04695	COG2137	regulation of response to DNA damage stimulus
HWV68_RS04705	COG2814	Major facilitator Superfamily
HWV68_RS04720	COG3103	Sh3 type 3 domain protein
HWV68_RS04725	COG5658	integral membrane protein
HWV68_RS04730	COG0596	Alpha beta hydrolase
HWV68_RS04735	COG0463	Glycosyl transferase, family 2
HWV68_RS04740	COG4485	Bacterial membrane protein, YfhO
HWV68_RS04745	COG1988	membrane-bound metal-dependent
HWV68_RS04750	COG1194	a g-specific adenine glycosylase
HWV68_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS04775	COG3557	Belongs to the UPF0374 family
HWV68_RS04780	COG1132	(ABC) transporter
HWV68_RS04785	COG4129	membrane
HWV68_RS04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWV68_RS04795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWV68_RS04800	COG0735	belongs to the Fur family
HWV68_RS04910	COG4326	sporulation control protein
HWV68_RS04920	COG5577	PFAM Coat F domain
HWV68_RS04925	COG3340	Belongs to the peptidase S51 family
HWV68_RS04930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HWV68_RS04935	COG0277	FAD linked oxidase domain protein
HWV68_RS04945	COG0753	catalase activity
HWV68_RS04950	COG1116	anion transmembrane transporter activity
HWV68_RS04955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWV68_RS04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWV68_RS04965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS04975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWV68_RS04985	COG1476	TRANSCRIPTIONal
HWV68_RS04995	COG3382	B3 4 domain protein
HWV68_RS05000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWV68_RS05010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWV68_RS05015	COG0789	Transcriptional regulator
HWV68_RS05020	COG1664	Polymer-forming cytoskeletal
HWV68_RS05025	COG1664	Polymer-forming cytoskeletal
HWV68_RS05030	COG2766	serine protein kinase
HWV68_RS05035	COG2718	Belongs to the UPF0229 family
HWV68_RS05040	COG1846	Transcriptional regulator
HWV68_RS05045	COG1566	PFAM secretion protein HlyD family protein
HWV68_RS05050	COG2814	Major facilitator Superfamily
HWV68_RS05055	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWV68_RS05075	COG1725	Transcriptional regulator
HWV68_RS05080	COG1131	(ABC) transporter
HWV68_RS05085	COG1131	(ABC) transporter
HWV68_RS05090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_RS05095	COG1278	Cold shock
HWV68_RS05100	COG1464	Belongs to the NlpA lipoprotein family
HWV68_RS05105	COG3706	GGDEF domain
HWV68_RS05110	COG1823	symporter activity
HWV68_RS05130	COG5577	PFAM Coat F domain
HWV68_RS05135	COG4085	toxin activity
HWV68_RS05135	COG1525	nuclease
HWV68_RS05135	COG0737	Belongs to the 5'-nucleotidase family
HWV68_RS05140	COG3764	Sortase (surface protein transpeptidase)
HWV68_RS05145	COG0564	pseudouridine synthase activity
HWV68_RS05155	COG0517	IMP dehydrogenase activity
HWV68_RS05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWV68_RS05165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWV68_RS05165	COG3153	acetyltransferase
HWV68_RS05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_RS05175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HWV68_RS05180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWV68_RS05185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWV68_RS05190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWV68_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWV68_RS05200	COG2203	Gaf domain
HWV68_RS05200	COG4585	Histidine kinase
HWV68_RS05205	COG2197	response regulator
HWV68_RS05210	COG0431	NADPH-dependent FMN reductase
HWV68_RS05225	COG0791	NLP P60 protein
HWV68_RS05225	COG1388	LysM domain
HWV68_RS05230	COG1959	2 iron, 2 sulfur cluster binding
HWV68_RS05235	COG0668	transmembrane transport
HWV68_RS05240	COG2719	SpoVR family
HWV68_RS05245	COG1785	Belongs to the alkaline phosphatase family
HWV68_RS05250	COG0791	NLP P60 protein
HWV68_RS05250	COG1388	LysM domain
HWV68_RS05255	COG0583	DNA-binding transcription factor activity
HWV68_RS05260	COG0372	Belongs to the citrate synthase family
HWV68_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS05270	COG0531	amino acid
HWV68_RS05275	COG0733	neurotransmitter:sodium symporter activity
HWV68_RS05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS05285	COG0456	acetyltransferase
HWV68_RS05300	COG1595	DNA-templated transcription, initiation
HWV68_RS05305	COG0667	Aldo Keto reductase
HWV68_RS05310	COG0204	Acyl-transferase
HWV68_RS05315	COG1253	flavin adenine dinucleotide binding
HWV68_RS05320	COG0789	Transcriptional regulator
HWV68_RS05325	COG0436	Aminotransferase
HWV68_RS05330	COG1253	flavin adenine dinucleotide binding
HWV68_RS05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWV68_RS05340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWV68_RS05345	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_RS05355	COG0668	transmembrane transport
HWV68_RS05360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWV68_RS05365	COG0726	polysaccharide deacetylase
HWV68_RS05370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_RS05375	COG1757	Na H antiporter
HWV68_RS05380	COG0589	response to stress
HWV68_RS05390	COG1132	(ABC) transporter
HWV68_RS05395	COG1132	(ABC) transporter
HWV68_RS05400	COG0702	epimerase
HWV68_RS05420	COG0189	ligase activity
HWV68_RS05425	COG0189	ligase activity
HWV68_RS05430	COG4399	Belongs to the UPF0754 family
HWV68_RS05435	COG3679	Belongs to the UPF0342 family
HWV68_RS05440	COG4335	DNA alkylation repair
HWV68_RS05445	COG0561	phosphatase activity
HWV68_RS05450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWV68_RS05455	COG0475	glutathione-regulated potassium exporter activity
HWV68_RS05460	COG0490	domain, Protein
HWV68_RS05470	COG1024	Enoyl-CoA hydratase
HWV68_RS05480	COG4152	abc transporter atp-binding protein
HWV68_RS05485	COG1668	transmembrane transport
HWV68_RS05490	COG0420	3'-5' exonuclease activity
HWV68_RS05495	COG4717	serine-type aminopeptidase activity
HWV68_RS05500	COG3481	metal-dependent phosphohydrolase, HD sub domain
HWV68_RS05510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWV68_RS05540	COG1846	Transcriptional regulator
HWV68_RS05545	COG4980	gas vesicle protein
HWV68_RS05560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HWV68_RS05565	COG0537	adenosine 5'-monophosphoramidase activity
HWV68_RS05570	COG1131	(ABC) transporter
HWV68_RS05575	COG4473	ABC transporter
HWV68_RS05585	COG1473	amidohydrolase
HWV68_RS05590	COG3069	C4-dicarboxylate transmembrane transporter activity
HWV68_RS05600	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_RS05605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_RS05610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HWV68_RS05625	COG1309	transcriptional regulator
HWV68_RS05630	COG1511	domain protein
HWV68_RS05635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_RS05640	COG4377	Putative membrane peptidase family (DUF2324)
HWV68_RS05650	COG1363	Peptidase, m42
HWV68_RS05655	COG4405	Protein conserved in bacteria
HWV68_RS05660	COG1301	dicarboxylic acid transport
HWV68_RS05670	COG1234	tRNA 3'-trailer cleavage
HWV68_RS05675	COG0095	Lipoate-protein ligase
HWV68_RS05680	COG0702	epimerase
HWV68_RS05685	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS05695	COG0501	Belongs to the peptidase M48B family
HWV68_RS05700	COG1404	Belongs to the peptidase S8 family
HWV68_RS05705	COG0456	acetyltransferase
HWV68_RS05710	COG0604	alcohol dehydrogenase
HWV68_RS05715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWV68_RS05720	COG0406	alpha-ribazole phosphatase activity
HWV68_RS05725	COG0183	Belongs to the thiolase family
HWV68_RS05730	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS05735	COG1268	BioY protein
HWV68_RS05740	COG0840	transmembrane signaling receptor activity
HWV68_RS05745	COG0723	plastoquinol--plastocyanin reductase activity
HWV68_RS05745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_RS05750	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS05760	COG4903	ComK protein
HWV68_RS05765	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS05775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_RS05790	COG0398	Pfam SNARE associated Golgi protein
HWV68_RS05795	COG0681	Belongs to the peptidase S26 family
HWV68_RS05800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV68_RS05805	COG1846	Transcriptional regulator
HWV68_RS05810	COG0738	Major facilitator superfamily
HWV68_RS05815	COG0673	inositol 2-dehydrogenase activity
HWV68_RS05820	COG0561	phosphatase activity
HWV68_RS05825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_RS05830	COG1609	Transcriptional regulator
HWV68_RS05835	COG3180	Ammonia monooxygenase
HWV68_RS05840	COG2814	Major facilitator Superfamily
HWV68_RS05840	COG0477	Major facilitator Superfamily
HWV68_RS05845	COG4533	DNA binding
HWV68_RS05855	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HWV68_RS05860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HWV68_RS05865	COG1074	ATP-dependent DNA helicase activity
HWV68_RS05870	COG0420	3'-5' exonuclease activity
HWV68_RS05875	COG0419	ATPase involved in DNA repair
HWV68_RS05880	COG1403	HNH endonuclease
HWV68_RS05920	COG5337	Spore coat protein CotH
HWV68_RS05925	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWV68_RS05935	COG1404	Belongs to the peptidase S8 family
HWV68_RS05945	COG0367	asparagine synthase
HWV68_RS05950	COG2318	DinB family
HWV68_RS05955	COG1562	ergosterol biosynthetic process
HWV68_RS05960	COG0534	Mate efflux family protein
HWV68_RS05965	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS05965	COG2207	Transcriptional regulator
HWV68_RS05970	COG1609	Transcriptional regulator
HWV68_RS05975	COG0673	inositol 2-dehydrogenase activity
HWV68_RS05980	COG2318	DinB family
HWV68_RS05985	COG1279	arginine transmembrane transporter activity
HWV68_RS05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_RS05995	COG1357	PFAM Pentapeptide repeats (8 copies)
HWV68_RS06000	COG2267	carboxylic ester hydrolase activity
HWV68_RS06005	COG0529	Catalyzes the synthesis of activated sulfate
HWV68_RS06010	COG2046	Belongs to the sulfate adenylyltransferase family
HWV68_RS06015	COG0175	sulfate reduction
HWV68_RS06020	COG2045	Belongs to the ComB family
HWV68_RS06025	COG1809	phosphosulfolactate synthase activity
HWV68_RS06030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS06035	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_RS06040	COG2814	Major facilitator Superfamily
HWV68_RS06045	COG0454	-acetyltransferase
HWV68_RS06050	COG2153	protein acetylation
HWV68_RS06055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWV68_RS06055	COG0646	methionine synthase
HWV68_RS06060	COG1666	GTP binding
HWV68_RS06065	COG2996	Protein conserved in bacteria
HWV68_RS06085	COG1695	Transcriptional regulator
HWV68_RS06100	COG3227	Zinc metalloprotease (Elastase)
HWV68_RS06105	COG1307	EDD domain protein, DegV family
HWV68_RS06110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS06130	COG0561	phosphatase activity
HWV68_RS06135	COG1073	alpha beta
HWV68_RS06140	COG2151	metal-sulfur cluster biosynthetic enzyme
HWV68_RS06150	COG0277	FAD linked oxidase domain protein
HWV68_RS06155	COG2271	Major facilitator Superfamily
HWV68_RS06160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HWV68_RS06165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWV68_RS06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWV68_RS06180	COG0505	Belongs to the CarA family
HWV68_RS06185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWV68_RS06190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HWV68_RS06205	COG2267	carboxylic ester hydrolase activity
HWV68_RS06215	COG1744	ABC transporter substrate-binding protein PnrA-like
HWV68_RS06230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_RS06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV68_RS06240	COG5504	Zn-dependent protease
HWV68_RS06245	COG0444	Belongs to the ABC transporter superfamily
HWV68_RS06250	COG4608	Belongs to the ABC transporter superfamily
HWV68_RS06260	COG0601	transmembrane transport
HWV68_RS06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_RS06275	COG0180	Tryptophanyl-tRNA synthetase
HWV68_RS06280	COG4166	transmembrane transport
HWV68_RS06285	COG0601	transmembrane transport
HWV68_RS06290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_RS06295	COG0444	Belongs to the ABC transporter superfamily
HWV68_RS06300	COG4608	Belongs to the ABC transporter superfamily
HWV68_RS06305	COG2814	Major facilitator Superfamily
HWV68_RS06310	COG0456	acetyltransferase
HWV68_RS06315	COG1393	Belongs to the ArsC family
HWV68_RS06320	COG0861	Integral membrane protein TerC family
HWV68_RS06330	COG4862	establishment of competence for transformation
HWV68_RS06340	COG4469	Competence protein
HWV68_RS06345	COG1164	Oligoendopeptidase f
HWV68_RS06360	COG2346	COG2346, Truncated hemoglobins
HWV68_RS06365	COG0741	lytic transglycosylase activity
HWV68_RS06370	COG4116	CYTH
HWV68_RS06380	COG2357	RelA SpoT domain protein
HWV68_RS06385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWV68_RS06390	COG0564	pseudouridine synthase activity
HWV68_RS06395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWV68_RS06400	COG0569	domain protein
HWV68_RS06400	COG0475	glutathione-regulated potassium exporter activity
HWV68_RS06405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWV68_RS06410	COG0352	thiamine-phosphate diphosphorylase activity
HWV68_RS06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_RS06420	COG2104	thiamine diphosphate biosynthetic process
HWV68_RS06425	COG2022	thiamine diphosphate biosynthetic process
HWV68_RS06430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWV68_RS06435	COG0351	phosphomethylpyrimidine kinase
HWV68_RS06440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWV68_RS06495	COG0210	DNA helicase
HWV68_RS06505	COG2153	protein acetylation
HWV68_RS06510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWV68_RS06515	COG2382	esterase
HWV68_RS06520	COG0626	cystathionine gamma-synthase activity
HWV68_RS06525	COG0626	cystathionine gamma-synthase activity
HWV68_RS06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS06535	COG5505	Protein of unknown function (DUF819)
HWV68_RS06570	COG3677	Transposase
HWV68_RS06585	COG5484	DNA packaging
HWV68_RS06590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWV68_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS06605	COG3711	transcriptional antiterminator
HWV68_RS06610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_RS06610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_RS06610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS06615	COG1482	cell wall glycoprotein biosynthetic process
HWV68_RS06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS06635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWV68_RS06650	COG0109	protoheme IX farnesyltransferase activity
HWV68_RS06660	COG0726	polysaccharide deacetylase
HWV68_RS06675	COG5504	Zn-dependent protease
HWV68_RS06680	COG2205	protein histidine kinase activity
HWV68_RS06690	COG3383	formate dehydrogenase (NAD+) activity
HWV68_RS06695	COG2427	Protein of unknown function (DUF1641)
HWV68_RS06705	COG1051	belongs to the nudix hydrolase family
HWV68_RS06715	COG2124	cytochrome p450
HWV68_RS06720	COG1819	glycosyl
HWV68_RS06730	COG1587	Uroporphyrinogen-III synthase
HWV68_RS06735	COG0390	transport system, permease component
HWV68_RS06740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_RS06745	COG0697	spore germination
HWV68_RS06750	COG4297	protein containing double-stranded beta helix domain
HWV68_RS06760	COG1252	NADH dehydrogenase
HWV68_RS06765	COG1904	glucuronate isomerase
HWV68_RS06770	COG2211	Major facilitator Superfamily
HWV68_RS06775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HWV68_RS06780	COG1063	alcohol dehydrogenase
HWV68_RS06785	COG1312	Catalyzes the dehydration of D-mannonate
HWV68_RS06790	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS06795	COG2271	Major facilitator Superfamily
HWV68_RS06800	COG1609	Transcriptional regulator
HWV68_RS06805	COG0246	Mannitol dehydrogenase
HWV68_RS06810	COG2721	sulfolactate sulfo-lyase activity
HWV68_RS06815	COG0730	response to heat
HWV68_RS06820	COG2318	DinB family
HWV68_RS06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWV68_RS06830	COG0457	Tetratricopeptide repeat
HWV68_RS06840	COG2350	Protein conserved in bacteria
HWV68_RS06845	COG1388	LysM domain
HWV68_RS06845	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS06845	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS06855	COG4195	phage-related replication protein
HWV68_RS06860	COG3546	catalase activity
HWV68_RS06865	COG2856	Zn peptidase
HWV68_RS06870	COG1396	sequence-specific DNA binding
HWV68_RS06880	COG1522	sequence-specific DNA binding
HWV68_RS06885	COG1484	DNA-dependent DNA replication
HWV68_RS06905	COG1595	DNA-templated transcription, initiation
HWV68_RS06910	COG5484	DNA packaging
HWV68_RS06910	COG3728	DNA packaging
HWV68_RS06915	COG1783	phage Terminase large subunit
HWV68_RS06920	COG5518	Phage portal protein
HWV68_RS06925	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HWV68_RS06930	COG4653	Phage capsid family
HWV68_RS06980	COG5412	phage tail tape measure protein
HWV68_RS06980	COG3953	SLT domain
HWV68_RS06985	COG1652	LysM domain
HWV68_RS06990	COG4193	domain, Protein
HWV68_RS07000	COG3628	GPW Gp25 family protein
HWV68_RS07005	COG3299	homolog of phage Mu protein gp47
HWV68_RS07010	COG3778	Protein conserved in bacteria
HWV68_RS07050	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS07050	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS07070	COG0306	phosphate transporter
HWV68_RS07075	COG1392	Phosphate transport regulator
HWV68_RS07080	COG0531	amino acid
HWV68_RS07085	COG0346	lactoylglutathione lyase activity
HWV68_RS07095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWV68_RS07100	COG0463	Glycosyl transferase, family 2
HWV68_RS07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_RS07115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_RS07120	COG2362	D-Aminopeptidase
HWV68_RS07125	COG0601	transmembrane transport
HWV68_RS07130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_RS07135	COG0444	Belongs to the ABC transporter superfamily
HWV68_RS07140	COG4166	transmembrane transport
HWV68_RS07145	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWV68_RS07150	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_RS07155	COG0791	NLP P60 protein
HWV68_RS07160	COG4608	Belongs to the ABC transporter superfamily
HWV68_RS07165	COG2706	6-phosphogluconolactonase activity
HWV68_RS07170	COG1834	amidinotransferase
HWV68_RS07175	COG1607	acyl-coa hydrolase
HWV68_RS07180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWV68_RS07180	COG1017	nitric oxide dioxygenase activity
HWV68_RS07190	COG2323	membrane
HWV68_RS07195	COG2318	DinB family
HWV68_RS07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS07205	COG2076	Multidrug Resistance protein
HWV68_RS07210	COG2076	Multidrug Resistance protein
HWV68_RS07215	COG0788	formyltetrahydrofolate deformylase activity
HWV68_RS07220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWV68_RS07225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HWV68_RS07230	COG1764	response to oxidative stress
HWV68_RS07235	COG1846	Transcriptional regulator
HWV68_RS07240	COG1764	response to oxidative stress
HWV68_RS07250	COG0590	tRNA wobble adenosine to inosine editing
HWV68_RS07255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_RS07260	COG1404	Belongs to the peptidase S8 family
HWV68_RS07265	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS07270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWV68_RS07275	COG1122	ATPase activity
HWV68_RS07280	COG4721	ABC-type cobalt transport system, permease component
HWV68_RS07290	COG0745	RESPONSE REGULATOR receiver
HWV68_RS07295	COG3850	Histidine kinase
HWV68_RS07295	COG5002	protein histidine kinase activity
HWV68_RS07300	COG3212	peptidase
HWV68_RS07305	COG3212	peptidase
HWV68_RS07315	COG2239	Acts as a magnesium transporter
HWV68_RS07320	COG0789	Transcriptional regulator
HWV68_RS07335	COG1846	Transcriptional regulator
HWV68_RS07340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_RS07345	COG0726	polysaccharide deacetylase
HWV68_RS07350	COG1408	metallophosphoesterase
HWV68_RS07360	COG0463	Glycosyl transferase, family 2
HWV68_RS07365	COG1793	dna ligase
HWV68_RS07365	COG3285	dna ligase
HWV68_RS07370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HWV68_RS07375	COG3300	MHYT domain
HWV68_RS07375	COG5001	Diguanylate cyclase
HWV68_RS07380	COG0586	Pfam SNARE associated Golgi protein
HWV68_RS07385	COG0861	Integral membrane protein TerC family
HWV68_RS07390	COG1191	sigma factor activity
HWV68_RS07410	COG0501	Belongs to the peptidase M48B family
HWV68_RS07415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWV68_RS07430	COG3594	Acyltransferase
HWV68_RS07435	COG5002	protein histidine kinase activity
HWV68_RS07440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWV68_RS07450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HWV68_RS07455	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HWV68_RS07460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWV68_RS07465	COG0436	Aminotransferase
HWV68_RS07470	COG1850	ribulose-bisphosphate carboxylase activity
HWV68_RS07475	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HWV68_RS07480	COG0235	Class ii aldolase
HWV68_RS07485	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HWV68_RS07490	COG3339	Conserved Protein
HWV68_RS07505	COG3852	Histidine kinase
HWV68_RS07510	COG1846	Transcriptional regulator
HWV68_RS07515	COG1360	Flagellar Motor Protein
HWV68_RS07520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWV68_RS07525	COG0542	response to heat
HWV68_RS07530	COG3949	Membrane
HWV68_RS07535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWV68_RS07540	COG0720	synthase
HWV68_RS07545	COG0602	queuosine metabolic process
HWV68_RS07550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HWV68_RS07555	COG1733	regulation of RNA biosynthetic process
HWV68_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS07565	COG4641	Protein conserved in bacteria
HWV68_RS07565	COG1388	LysM domain
HWV68_RS07570	COG1388	LysM domain
HWV68_RS07585	COG4873	Protein conserved in bacteria
HWV68_RS07595	COG3773	Cell wall hydrolase
HWV68_RS07600	COG2244	polysaccharide biosynthetic process
HWV68_RS07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS07610	COG2217	Heavy metal translocating P-type atpase
HWV68_RS07620	COG0006	proline dipeptidase activity
HWV68_RS07625	COG1609	Transcriptional regulator
HWV68_RS07630	COG3711	transcriptional antiterminator
HWV68_RS07635	COG1263	PTS System
HWV68_RS07635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS07635	COG2190	(PTS) system
HWV68_RS07640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS07645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWV68_RS07655	COG1533	DNA photolyase activity
HWV68_RS07660	COG0456	acetyltransferase
HWV68_RS07665	COG0840	transmembrane signaling receptor activity
HWV68_RS07670	COG2084	Dehydrogenase
HWV68_RS07675	COG2340	Cysteine-rich secretory protein family
HWV68_RS07680	COG0768	penicillin binding
HWV68_RS07685	COG4191	Histidine kinase
HWV68_RS07690	COG0436	Aminotransferase
HWV68_RS07700	COG0784	Response regulator, receiver
HWV68_RS07700	COG0835	chemotaxis
HWV68_RS07710	COG2814	Major facilitator Superfamily
HWV68_RS07715	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_RS07720	COG1408	metallophosphoesterase
HWV68_RS07725	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS07730	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS07735	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS07745	COG2200	EAL domain
HWV68_RS07750	COG4703	Protein of unknown function (DUF1797)
HWV68_RS07755	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HWV68_RS07765	COG0517	IMP dehydrogenase activity
HWV68_RS07770	COG0583	DNA-binding transcription factor activity
HWV68_RS07775	COG0716	FMN binding
HWV68_RS07785	COG0716	FMN binding
HWV68_RS07790	COG2171	N-acyltransferase activity
HWV68_RS07795	COG1473	amidohydrolase
HWV68_RS07805	COG0668	transmembrane transport
HWV68_RS07810	COG0450	alkyl hydroperoxide reductase
HWV68_RS07815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS07830	COG0746	molybdenum cofactor guanylyltransferase activity
HWV68_RS07835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWV68_RS07840	COG0303	'Molybdopterin
HWV68_RS07845	COG1763	Mo-molybdopterin cofactor biosynthetic process
HWV68_RS07850	COG0314	molybdopterin synthase activity
HWV68_RS07855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HWV68_RS07860	COG1132	(ABC) transporter
HWV68_RS07865	COG1132	(ABC) transporter
HWV68_RS07875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWV68_RS07880	COG1136	(ABC) transporter
HWV68_RS07885	COG0577	efflux transmembrane transporter activity
HWV68_RS07890	COG1349	DNA-binding transcription factor activity
HWV68_RS07895	COG1105	Belongs to the carbohydrate kinase PfkB family
HWV68_RS07900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_RS07900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_RS07900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS07905	COG0681	Belongs to the peptidase S26 family
HWV68_RS07915	COG0488	(ABC) transporter
HWV68_RS07920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWV68_RS07925	COG2309	aminopeptidase activity
HWV68_RS07935	COG1077	Cell shape determining protein MreB Mrl
HWV68_RS07940	COG2002	toxin-antitoxin pair type II binding
HWV68_RS07945	COG3852	Histidine kinase
HWV68_RS07950	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HWV68_RS07950	COG2105	PFAM AIG2 family protein
HWV68_RS07955	COG0569	domain protein
HWV68_RS07960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWV68_RS07965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWV68_RS07975	COG0561	phosphatase activity
HWV68_RS07980	COG0242	peptide deformylase activity
HWV68_RS07990	COG0497	DNA recombination
HWV68_RS07995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_RS08000	COG0022	dehydrogenase e1 component
HWV68_RS08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_RS08010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_RS08015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS08025	COG1982	Orn Lys Arg decarboxylase major
HWV68_RS08030	COG4476	Belongs to the UPF0223 family
HWV68_RS08035	COG4493	Belongs to the UPF0637 family
HWV68_RS08045	COG0483	inositol monophosphate 1-phosphatase activity
HWV68_RS08055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWV68_RS08075	COG1595	DNA-templated transcription, initiation
HWV68_RS08105	COG4896	Protein conserved in bacteria
HWV68_RS08115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWV68_RS08120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWV68_RS08125	COG2066	Belongs to the glutaminase family
HWV68_RS08130	COG4838	Belongs to the UPF0358 family
HWV68_RS08135	COG0772	Belongs to the SEDS family
HWV68_RS08140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HWV68_RS08145	COG1612	heme a metabolic process
HWV68_RS08150	COG0109	protoheme IX farnesyltransferase activity
HWV68_RS08155	COG2010	Cytochrome c
HWV68_RS08155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWV68_RS08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWV68_RS08165	COG1845	cytochrome c oxidase, subunit III
HWV68_RS08170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWV68_RS08175	COG3336	cytochrome c oxidase
HWV68_RS08185	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HWV68_RS08190	COG2340	Cysteine-rich secretory protein family
HWV68_RS08205	COG3679	Belongs to the UPF0342 family
HWV68_RS08210	COG4471	UPF0298 protein
HWV68_RS08215	COG0742	ribosomal rna small subunit methyltransferase
HWV68_RS08220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HWV68_RS08225	COG3314	Sporulation integral membrane protein YlbJ
HWV68_RS08230	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWV68_RS08235	COG3480	Lon protease (S16) C-terminal proteolytic domain
HWV68_RS08240	COG1323	Belongs to the UPF0348 family
HWV68_RS08250	COG1399	metal-binding, possibly nucleic acid-binding protein
HWV68_RS08265	COG0454	-acetyltransferase
HWV68_RS08270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWV68_RS08275	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HWV68_RS08280	COG2001	Belongs to the MraZ family
HWV68_RS08285	COG0275	rRNA processing
HWV68_RS08290	COG4839	cell division protein FtsL
HWV68_RS08300	COG0768	penicillin binding
HWV68_RS08305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWV68_RS08310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWV68_RS08315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWV68_RS08320	COG0772	Belongs to the SEDS family
HWV68_RS08325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_RS08330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HWV68_RS08335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWV68_RS08340	COG3879	Bacterial protein of unknown function (DUF881)
HWV68_RS08345	COG3879	Bacterial protein of unknown function (DUF881)
HWV68_RS08350	COG3856	small basic protein
HWV68_RS08355	COG0849	cell division
HWV68_RS08360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWV68_RS08365	COG1404	Belongs to the peptidase S8 family
HWV68_RS08365	COG4412	M6 family metalloprotease domain protein
HWV68_RS08375	COG1191	sigma factor activity
HWV68_RS08380	COG1191	sigma factor activity
HWV68_RS08385	COG1119	ATPase activity
HWV68_RS08390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_RS08395	COG1873	PFAM PRC-barrel domain
HWV68_RS08405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HWV68_RS08410	COG1799	cell septum assembly
HWV68_RS08415	COG0762	integral membrane protein
HWV68_RS08420	COG2302	S4 RNA-binding domain
HWV68_RS08425	COG3599	regulation of cell shape
HWV68_RS08430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWV68_RS08435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_RS08440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HWV68_RS08445	COG0564	pseudouridine synthase activity
HWV68_RS08450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HWV68_RS08455	COG2233	PERMEase
HWV68_RS08460	COG0540	Belongs to the ATCase OTCase family
HWV68_RS08465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV68_RS08470	COG0505	Belongs to the CarA family
HWV68_RS08475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWV68_RS08480	COG0543	2 iron, 2 sulfur cluster binding
HWV68_RS08485	COG0167	dihydroorotate dehydrogenase activity
HWV68_RS08490	COG0284	orotidine-5'-phosphate decarboxylase activity
HWV68_RS08495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWV68_RS08500	COG0175	sulfate reduction
HWV68_RS08505	COG0306	phosphate transporter
HWV68_RS08510	COG2046	Belongs to the sulfate adenylyltransferase family
HWV68_RS08515	COG0529	Catalyzes the synthesis of activated sulfate
HWV68_RS08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWV68_RS08525	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HWV68_RS08530	COG1648	precorrin-2 dehydrogenase activity
HWV68_RS08535	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HWV68_RS08540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWV68_RS08545	COG1561	YicC-like family, N-terminal region
HWV68_RS08555	COG0194	GDP metabolic process
HWV68_RS08560	COG1758	RNA polymerase activity
HWV68_RS08565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWV68_RS08570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWV68_RS08575	COG0242	peptide deformylase activity
HWV68_RS08580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWV68_RS08585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV68_RS08585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWV68_RS08590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HWV68_RS08595	COG0631	protein serine/threonine phosphatase activity
HWV68_RS08600	COG0515	serine threonine protein kinase
HWV68_RS08600	COG2815	serine threonine protein kinase
HWV68_RS08605	COG1162	GTPase activity
HWV68_RS08610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWV68_RS08615	COG1564	THIamine pyrophosphokinase
HWV68_RS08625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWV68_RS08630	COG1302	Protein conserved in bacteria
HWV68_RS08635	COG1461	Dihydroxyacetone kinase
HWV68_RS08640	COG1760	l-serine dehydratase
HWV68_RS08645	COG1760	l-serine dehydratase
HWV68_RS08650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWV68_RS08655	COG1349	DNA-binding transcription factor activity
HWV68_RS08655	COG2050	protein possibly involved in aromatic compounds catabolism
HWV68_RS08660	COG0416	fatty acid biosynthetic process
HWV68_RS08665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_RS08670	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS08680	COG0571	ribonuclease III activity
HWV68_RS08685	COG1196	nuclear chromosome segregation
HWV68_RS08690	COG0552	protein localization to endoplasmic reticulum
HWV68_RS08700	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HWV68_RS08705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWV68_RS08710	COG0228	four-way junction DNA binding
HWV68_RS08715	COG1837	Belongs to the UPF0109 family
HWV68_RS08725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWV68_RS08730	COG0336	Belongs to the RNA methyltransferase TrmD family
HWV68_RS08735	COG0335	large ribosomal subunit rRNA binding
HWV68_RS08740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWV68_RS08745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWV68_RS08755	COG2257	FlhB HrpN YscU SpaS Family
HWV68_RS08760	COG0045	succinate-CoA ligase (ADP-forming) activity
HWV68_RS08765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HWV68_RS08770	COG0758	DNA mediated transformation
HWV68_RS08775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWV68_RS08780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HWV68_RS08785	COG4974	Belongs to the 'phage' integrase family
HWV68_RS08790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HWV68_RS08795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HWV68_RS08800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWV68_RS08805	COG1815	bacterial-type flagellum-dependent cell motility
HWV68_RS08810	COG1558	bacterial-type flagellum-dependent cell motility
HWV68_RS08815	COG1677	Flagellar hook-basal body complex protein FliE
HWV68_RS08820	COG1766	The M ring may be actively involved in energy transduction
HWV68_RS08825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_RS08830	COG1317	bacterial-type flagellum organization
HWV68_RS08835	COG1157	protein secretion by the type III secretion system
HWV68_RS08840	COG2882	bacterial-type flagellum organization
HWV68_RS08845	COG3334	PFAM MgtE intracellular
HWV68_RS08850	COG3144	bacterial-type flagellum assembly
HWV68_RS08855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HWV68_RS08860	COG4786	Flagellar basal body rod
HWV68_RS08865	COG1582	Flagellar protein (FlbD)
HWV68_RS08870	COG1580	Controls the rotational direction of flagella during chemotaxis
HWV68_RS08875	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_RS08880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_RS08880	COG1776	CheC inhibitor of MCP methylation
HWV68_RS08885	COG2201	protein-glutamate methylesterase activity
HWV68_RS08890	COG3190	flagellar
HWV68_RS08895	COG1338	Plays a role in the flagellum-specific transport system
HWV68_RS08900	COG1987	bacterial-type flagellum assembly
HWV68_RS08905	COG1684	flagellar biosynthetic protein fliR
HWV68_RS08910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWV68_RS08915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWV68_RS08920	COG1419	protein localization to endoplasmic reticulum
HWV68_RS08925	COG0455	bacterial-type flagellum organization
HWV68_RS08930	COG2201	protein-glutamate methylesterase activity
HWV68_RS08935	COG0643	Histidine kinase
HWV68_RS08935	COG2198	Histidine kinase
HWV68_RS08940	COG0835	chemotaxis
HWV68_RS08945	COG1776	CheC inhibitor of MCP methylation
HWV68_RS08950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HWV68_RS08955	COG1191	sigma factor activity
HWV68_RS08965	COG0052	Belongs to the universal ribosomal protein uS2 family
HWV68_RS08970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HWV68_RS08975	COG0528	UMP kinase activity
HWV68_RS08980	COG0233	cytoplasmic translational termination
HWV68_RS08985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWV68_RS08990	COG4589	Belongs to the CDS family
HWV68_RS08995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HWV68_RS09000	COG0750	zinc metalloprotease
HWV68_RS09005	COG0442	prolyl-tRNA aminoacylation
HWV68_RS09010	COG2176	DNA-directed DNA polymerase activity
HWV68_RS09015	COG0779	Required for maturation of 30S ribosomal subunits
HWV68_RS09020	COG0195	Participates in both transcription termination and antitermination
HWV68_RS09025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HWV68_RS09030	COG1358	cellular component organization or biogenesis
HWV68_RS09035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HWV68_RS09040	COG1550	Protein conserved in bacteria
HWV68_RS09045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWV68_RS09050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWV68_RS09055	COG0196	riboflavin kinase activity
HWV68_RS09060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HWV68_RS09065	COG1185	polyribonucleotide nucleotidyltransferase activity
HWV68_RS09070	COG0726	polysaccharide deacetylase
HWV68_RS09075	COG0612	Peptidase, M16
HWV68_RS09080	COG1873	PFAM PRC-barrel domain
HWV68_RS09085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWV68_RS09090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWV68_RS09095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HWV68_RS09100	COG0527	aspartate kinase activity
HWV68_RS09105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWV68_RS09110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWV68_RS09115	COG0740	serine-type endopeptidase activity
HWV68_RS09125	COG1674	ftsk spoiiie
HWV68_RS09125	COG4980	gas vesicle protein
HWV68_RS09130	COG2188	Transcriptional regulator
HWV68_RS09135	COG2814	Major facilitator Superfamily
HWV68_RS09140	COG0612	Peptidase, M16
HWV68_RS09145	COG0612	Peptidase, M16
HWV68_RS09150	COG0300	oxidoreductase activity
HWV68_RS09165	COG1426	Protein conserved in bacteria
HWV68_RS09170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWV68_RS09175	COG1546	Belongs to the CinA family
HWV68_RS09175	COG1058	Belongs to the CinA family
HWV68_RS09180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWV68_RS09185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_RS09190	COG1418	mRNA catabolic process
HWV68_RS09195	COG1692	metallophosphoesterase
HWV68_RS09200	COG2359	stage V sporulation protein S
HWV68_RS09205	COG1063	alcohol dehydrogenase
HWV68_RS09210	COG0156	8-amino-7-oxononanoate synthase activity
HWV68_RS09215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV68_RS09220	COG4550	Control of competence regulator ComK, YlbF/YmcA
HWV68_RS09230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HWV68_RS09235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWV68_RS09250	COG3226	Transcriptional regulator
HWV68_RS09255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS09265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_RS09270	COG3321	synthase
HWV68_RS09275	COG2070	2-Nitropropane dioxygenase
HWV68_RS09275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_RS09280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_RS09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV68_RS09290	COG3425	synthase
HWV68_RS09295	COG1024	Enoyl-CoA hydratase
HWV68_RS09300	COG1024	Enoyl-CoA hydratase
HWV68_RS09305	COG0300	oxidoreductase activity
HWV68_RS09305	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS09305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS09305	COG3321	synthase
HWV68_RS09310	COG3321	synthase
HWV68_RS09310	COG4221	oxidoreductase activity
HWV68_RS09310	COG0300	oxidoreductase activity
HWV68_RS09310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_RS09315	COG3321	synthase
HWV68_RS09315	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS09315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_RS09315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_RS09315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09320	COG3321	synthase
HWV68_RS09320	COG4221	oxidoreductase activity
HWV68_RS09320	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS09320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09325	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWV68_RS09325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWV68_RS09325	COG3321	synthase
HWV68_RS09325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_RS09330	COG2124	cytochrome p450
HWV68_RS09340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS09345	COG1404	Belongs to the peptidase S8 family
HWV68_RS09350	COG4195	phage-related replication protein
HWV68_RS09355	COG1764	response to oxidative stress
HWV68_RS09360	COG2076	Multidrug Resistance protein
HWV68_RS09365	COG2076	Multidrug Resistance protein
HWV68_RS09380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWV68_RS09385	COG1923	regulation of RNA biosynthetic process
HWV68_RS09400	COG1780	Probably involved in ribonucleotide reductase function
HWV68_RS09405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_RS09410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_RS09415	COG4112	unkown
HWV68_RS09420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS09425	COG0464	growth
HWV68_RS09430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWV68_RS09435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HWV68_RS09440	COG0789	Transcriptional regulator
HWV68_RS09445	COG0174	glutamine synthetase
HWV68_RS09465	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_RS09475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS09505	COG0135	phosphoribosylanthranilate isomerase activity
HWV68_RS09510	COG2211	Major facilitator Superfamily
HWV68_RS09515	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_RS09520	COG1940	carbohydrate kinase activity
HWV68_RS09525	COG2115	Belongs to the xylose isomerase family
HWV68_RS09530	COG1070	Carbohydrate kinase
HWV68_RS09540	COG1525	nuclease
HWV68_RS09545	COG2814	Major facilitator Superfamily
HWV68_RS09550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWV68_RS09560	COG0756	dUTP diphosphatase activity
HWV68_RS09575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWV68_RS09600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_RS09615	COG3832	glyoxalase III activity
HWV68_RS09625	COG0697	spore germination
HWV68_RS09630	COG0531	amino acid
HWV68_RS09660	COG4195	phage-related replication protein
HWV68_RS09670	COG0346	lactoylglutathione lyase activity
HWV68_RS09675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWV68_RS09680	COG1388	LysM domain
HWV68_RS09685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_RS09690	COG4224	UPF0291 protein
HWV68_RS09695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWV68_RS09705	COG3763	UPF0154 protein
HWV68_RS09715	COG0785	Cytochrome C biogenesis protein
HWV68_RS09720	COG2201	protein-glutamate methylesterase activity
HWV68_RS09725	COG4846	Membrane protein involved in cytochrome C biogenesis
HWV68_RS09735	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_RS09750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWV68_RS09755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS09775	COG0824	Thioesterase
HWV68_RS09785	COG4841	protein insertion into membrane
HWV68_RS09790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HWV68_RS09795	COG1832	CoA-binding protein
HWV68_RS09800	COG0187	DNA topoisomerase II activity
HWV68_RS09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV68_RS09815	COG1115	amino acid carrier protein
HWV68_RS09820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HWV68_RS09830	COG5520	Belongs to the glycosyl hydrolase 30 family
HWV68_RS09835	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_RS09840	COG2246	polysaccharide biosynthetic process
HWV68_RS09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_RS09850	COG0586	Pfam SNARE associated Golgi protein
HWV68_RS09855	COG2404	hydrolase activity, acting on ester bonds
HWV68_RS09860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWV68_RS09865	COG1024	Enoyl-CoA hydratase
HWV68_RS09870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWV68_RS09875	COG0511	ligase activity, forming carbon-carbon bonds
HWV68_RS09880	COG0439	Biotin carboxylase
HWV68_RS09885	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS09890	COG1960	acyl-CoA dehydrogenase activity
HWV68_RS09905	COG1649	PFAM Uncharacterised BCR, COG1649
HWV68_RS09915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWV68_RS09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS09940	COG2027	D-alanyl-D-alanine carboxypeptidase
HWV68_RS09945	COG2017	converts alpha-aldose to the beta-anomer
HWV68_RS09950	COG0534	Mate efflux family protein
HWV68_RS09965	COG0582	viral genome integration into host DNA
HWV68_RS09970	COG0166	Belongs to the GPI family
HWV68_RS09975	COG0405	Gamma-glutamyltransferase
HWV68_RS09980	COG0583	DNA-binding transcription factor activity
HWV68_RS09985	COG0604	alcohol dehydrogenase
HWV68_RS09990	COG0493	'glutamate synthase
HWV68_RS09995	COG0069	glutamate synthase activity
HWV68_RS09995	COG0070	glutamate synthase
HWV68_RS09995	COG0067	glutamate synthase
HWV68_RS10000	COG0583	DNA-binding transcription factor activity
HWV68_RS10005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWV68_RS10010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_RS10020	COG0300	oxidoreductase activity
HWV68_RS10025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWV68_RS10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS10040	COG2814	Major facilitator Superfamily
HWV68_RS10045	COG1070	Carbohydrate kinase
HWV68_RS10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWV68_RS10055	COG0243	molybdopterin cofactor binding
HWV68_RS10085	COG5278	phosphoserine phosphatase activity
HWV68_RS10085	COG0840	transmembrane signaling receptor activity
HWV68_RS10090	COG2368	4-hydroxyphenylacetate
HWV68_RS10095	COG4305	rare lipoprotein A
HWV68_RS10100	COG3619	membrane
HWV68_RS10105	COG3866	Pectate lyase
HWV68_RS10110	COG2135	peptidase activity
HWV68_RS10120	COG2140	Oxalate decarboxylase
HWV68_RS10135	COG0456	acetyltransferase
HWV68_RS10155	COG2720	vancomycin resistance protein
HWV68_RS10165	COG3655	Transcriptional regulator
HWV68_RS10170	COG3739	integral membrane protein
HWV68_RS10175	COG0583	DNA-binding transcription factor activity
HWV68_RS10180	COG0697	spore germination
HWV68_RS10190	COG0693	protein deglycase activity
HWV68_RS10195	COG2367	Beta-lactamase
HWV68_RS10210	COG3848	Pyruvate phosphate dikinase
HWV68_RS10210	COG0574	Belongs to the PEP-utilizing enzyme family
HWV68_RS10215	COG0726	polysaccharide deacetylase
HWV68_RS10220	COG2314	TM2 domain
HWV68_RS10225	COG1396	sequence-specific DNA binding
HWV68_RS10240	COG2135	peptidase activity
HWV68_RS10275	COG0457	Tetratricopeptide repeat
HWV68_RS10300	COG5290	Psort location Cytoplasmic, score
HWV68_RS10325	COG5444	nuclease activity
HWV68_RS10330	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_RS10335	COG1231	oxidoreductase activity
HWV68_RS10340	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_RS10345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_RS10350	COG2207	Transcriptional regulator
HWV68_RS10350	COG0662	Cupin 2, conserved barrel domain protein
HWV68_RS10355	COG0456	acetyltransferase
HWV68_RS10360	COG1309	transcriptional regulator
HWV68_RS10365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS10370	COG3708	Transcriptional regulator
HWV68_RS10375	COG2378	regulation of single-species biofilm formation
HWV68_RS10385	COG0640	Transcriptional regulator
HWV68_RS10390	COG0741	lytic transglycosylase activity
HWV68_RS10395	COG2322	membrane
HWV68_RS10410	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWV68_RS10415	COG3239	Fatty acid desaturase
HWV68_RS10420	COG4585	Histidine kinase
HWV68_RS10425	COG2197	response regulator
HWV68_RS10430	COG3584	3D domain protein
HWV68_RS10430	COG1388	LysM domain
HWV68_RS10435	COG0514	ATP-dependent DNA helicase (RecQ)
HWV68_RS10445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWV68_RS10450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_RS10465	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_RS10490	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS10495	COG1657	PFAM Prenyltransferase squalene oxidase
HWV68_RS10500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWV68_RS10505	COG0733	neurotransmitter:sodium symporter activity
HWV68_RS10510	COG0385	Bile acid
HWV68_RS10515	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_RS10520	COG0567	Dehydrogenase, E1 component
HWV68_RS10525	COG4548	von Willebrand factor, type A
HWV68_RS10530	COG0714	Associated with various cellular activities
HWV68_RS10535	COG2032	superoxide dismutase activity
HWV68_RS10540	COG1388	LysM domain
HWV68_RS10540	COG0791	NLP P60 protein
HWV68_RS10545	COG1819	glycosyl
HWV68_RS10550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWV68_RS10555	COG0534	Mate efflux family protein
HWV68_RS10560	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS10565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_RS10570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_RS10580	COG2962	Rard protein
HWV68_RS10595	COG2610	gluconate transmembrane transporter activity
HWV68_RS10600	COG1942	4-Oxalocrotonate Tautomerase
HWV68_RS10605	COG1733	regulation of RNA biosynthetic process
HWV68_RS10610	COG0778	Nitroreductase
HWV68_RS10615	COG0400	carboxylic ester hydrolase activity
HWV68_RS10620	COG0346	lactoylglutathione lyase activity
HWV68_RS10630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_RS10635	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS10635	COG0793	Belongs to the peptidase S41A family
HWV68_RS10640	COG2226	methyltransferase
HWV68_RS10650	COG1876	peptidase activity
HWV68_RS10655	COG0813	purine-nucleoside phosphorylase activity
HWV68_RS10670	COG0671	phosphoesterase, PA-phosphatase related
HWV68_RS10690	COG4479	Belongs to the UPF0346 family
HWV68_RS10700	COG1509	lysine 2,3-aminomutase activity
HWV68_RS10705	COG0456	acetyltransferase
HWV68_RS10710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_RS10715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWV68_RS10720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWV68_RS10725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_RS10740	COG0456	acetyltransferase
HWV68_RS10745	COG0463	Glycosyl transferase, family 2
HWV68_RS10760	COG4641	Protein conserved in bacteria
HWV68_RS10765	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HWV68_RS10770	COG1086	Polysaccharide biosynthesis protein
HWV68_RS10780	COG3331	DNA recombination
HWV68_RS10835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_RS10870	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HWV68_RS10875	COG0756	dUTP diphosphatase activity
HWV68_RS10880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS10900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_RS10900	COG1372	Participates in initiation and elongation during chromosome replication
HWV68_RS10905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_RS10905	COG1372	Participates in initiation and elongation during chromosome replication
HWV68_RS10910	COG1780	Probably involved in ribonucleotide reductase function
HWV68_RS11000	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_RS11010	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HWV68_RS11015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWV68_RS11040	COG3584	3D domain protein
HWV68_RS11045	COG0587	DNA-directed DNA polymerase activity
HWV68_RS11050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWV68_RS11055	COG0358	DNA primase activity
HWV68_RS11060	COG0305	Participates in initiation and elongation during chromosome replication
HWV68_RS11070	COG2887	Belongs to the helicase family. UvrD subfamily
HWV68_RS11100	COG3420	alginic acid biosynthetic process
HWV68_RS11100	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_RS11105	COG4195	phage-related replication protein
HWV68_RS11120	COG2135	peptidase activity
HWV68_RS11125	COG1793	dna ligase
HWV68_RS11180	COG4474	Belongs to the UPF0398 family
HWV68_RS11190	COG1388	LysM domain
HWV68_RS11210	COG3645	SOS response
HWV68_RS11210	COG3646	Phage regulatory protein
HWV68_RS11265	COG3655	Transcriptional regulator
HWV68_RS11280	COG0582	viral genome integration into host DNA
HWV68_RS11360	COG3655	Transcriptional regulator
HWV68_RS11400	COG1395	domain, Protein
HWV68_RS11415	COG0776	regulation of translation
HWV68_RS11450	COG4373	Mu-like prophage FluMu protein gp28
HWV68_RS11550	COG0582	viral genome integration into host DNA
HWV68_RS11580	COG1196	nuclear chromosome segregation
HWV68_RS11580	COG0741	lytic transglycosylase activity
HWV68_RS11580	COG0739	heme binding
HWV68_RS11590	COG2433	Pfam Transposase IS66
HWV68_RS11600	COG4632	Exopolysaccharide biosynthesis protein
HWV68_RS11600	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_RS11615	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS11630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWV68_RS11635	COG0463	Glycosyl transferase, family 2
HWV68_RS11640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS11645	COG3271	cysteine-type peptidase activity
HWV68_RS11645	COG2274	protein secretion by the type I secretion system
HWV68_RS11660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_RS11690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_RS11705	COG5444	nuclease activity
HWV68_RS11710	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_RS11725	COG1525	nuclease
HWV68_RS11735	COG2746	aminoglycoside 3-N-acetyltransferase activity
HWV68_RS11760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_RS11765	COG1086	Polysaccharide biosynthesis protein
HWV68_RS11770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWV68_RS11775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWV68_RS11780	COG1846	Transcriptional regulator
HWV68_RS11785	COG0534	Mate efflux family protein
HWV68_RS11795	COG4698	Protein conserved in bacteria
HWV68_RS11800	COG2755	lipolytic protein G-D-S-L family
HWV68_RS11805	COG1999	signal sequence binding
HWV68_RS11815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWV68_RS11820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HWV68_RS11825	COG1272	protein, Hemolysin III
HWV68_RS11830	COG0204	Acyl-transferase
HWV68_RS11835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_RS11840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWV68_RS11845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWV68_RS11855	COG2521	methyltransferase
HWV68_RS11855	COG2136	Putative SAM-dependent methyltransferase
HWV68_RS11865	COG0129	dihydroxy-acid dehydratase activity
HWV68_RS11870	COG1413	lyase activity
HWV68_RS11875	COG1418	mRNA catabolic process
HWV68_RS11880	COG0386	Belongs to the glutathione peroxidase family
HWV68_RS11885	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HWV68_RS11890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_RS11900	COG1278	Cold shock
HWV68_RS11920	COG0328	RNA-DNA hybrid ribonuclease activity
HWV68_RS11925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HWV68_RS11930	COG0328	RNA-DNA hybrid ribonuclease activity
HWV68_RS11940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_RS11955	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWV68_RS11965	COG1755	Isoprenylcysteine carboxyl methyltransferase
HWV68_RS11970	COG3424	synthase
HWV68_RS11975	COG2233	PERMEase
HWV68_RS11980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_RS11985	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HWV68_RS11995	COG0800	Aldolase
HWV68_RS12000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_RS12005	COG1609	Transcriptional regulator
HWV68_RS12010	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HWV68_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS12020	COG1199	ATP-dependent helicase activity
HWV68_RS12035	COG0116	Belongs to the methyltransferase superfamily
HWV68_RS12050	COG4474	Belongs to the UPF0398 family
HWV68_RS12065	COG3359	exonuclease
HWV68_RS12070	COG1205	dead DEAH box helicase
HWV68_RS12070	COG1111	helicase
HWV68_RS12075	COG2190	(PTS) system
HWV68_RS12080	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_RS12115	COG3331	DNA recombination
HWV68_RS12120	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWV68_RS12120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_RS12130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWV68_RS12135	COG3935	DnaD domain protein
HWV68_RS12140	COG0017	Asparaginyl-tRNA synthetase
HWV68_RS12145	COG0436	Aminotransferase
HWV68_RS12150	COG5353	protein conserved in bacteria
HWV68_RS12160	COG1199	ATP-dependent helicase activity
HWV68_RS12160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWV68_RS12165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HWV68_RS12170	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HWV68_RS12175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HWV68_RS12180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HWV68_RS12180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HWV68_RS12185	COG0617	tRNA 3'-terminal CCA addition
HWV68_RS12190	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS12195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_RS12200	COG1803	Methylglyoxal synthase
HWV68_RS12205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HWV68_RS12210	COG1694	Mazg nucleotide pyrophosphohydrolase
HWV68_RS12215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS12225	COG4347	Protein of unknown function (DUF1405)
HWV68_RS12230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWV68_RS12230	COG2010	Cytochrome c
HWV68_RS12235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWV68_RS12240	COG0723	plastoquinol--plastocyanin reductase activity
HWV68_RS12250	COG5582	Belongs to the UPF0302 family
HWV68_RS12255	COG0457	Tetratricopeptide repeat
HWV68_RS12260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWV68_RS12265	COG0287	Prephenate dehydrogenase
HWV68_RS12270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWV68_RS12275	COG0159	tryptophan synthase activity
HWV68_RS12280	COG0133	tryptophan synthase activity
HWV68_RS12285	COG0135	phosphoribosylanthranilate isomerase activity
HWV68_RS12295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWV68_RS12300	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWV68_RS12305	COG4401	Chorismate mutase type I
HWV68_RS12310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HWV68_RS12315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HWV68_RS12320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HWV68_RS12325	COG0105	UTP biosynthetic process
HWV68_RS12330	COG0142	geranyltranstransferase activity
HWV68_RS12335	COG2226	methyltransferase
HWV68_RS12340	COG0142	geranyltranstransferase activity
HWV68_RS12350	COG0302	gtp cyclohydrolase
HWV68_RS12355	COG0776	regulation of translation
HWV68_RS12360	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWV68_RS12375	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HWV68_RS12380	COG1160	GTP binding
HWV68_RS12405	COG1304	FMN binding
HWV68_RS12410	COG0539	negative regulation of cytoplasmic translation
HWV68_RS12415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HWV68_RS12425	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HWV68_RS12430	COG2959	enzyme of heme biosynthesis
HWV68_RS12435	COG3773	Cell wall hydrolase
HWV68_RS12435	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS12440	COG2339	peptidase activity
HWV68_RS12445	COG0492	ferredoxin-NADP+ reductase activity
HWV68_RS12450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_RS12455	COG4862	establishment of competence for transformation
HWV68_RS12460	COG1408	metallophosphoesterase
HWV68_RS12470	COG1388	LysM domain
HWV68_RS12475	COG1266	CAAX protease self-immunity
HWV68_RS12480	COG0514	ATP-dependent DNA helicase (RecQ)
HWV68_RS12485	COG4955	Helix-turn-helix domain
HWV68_RS12490	COG1141	Ferredoxin
HWV68_RS12495	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HWV68_RS12500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWV68_RS12505	COG0710	3-dehydroquinate dehydratase activity
HWV68_RS12515	COG1595	DNA-templated transcription, initiation
HWV68_RS12520	COG5002	protein histidine kinase activity
HWV68_RS12525	COG0745	RESPONSE REGULATOR receiver
HWV68_RS12530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV68_RS12535	COG1333	cytochrome c biogenesis protein
HWV68_RS12540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS12545	COG1187	pseudouridine synthase activity
HWV68_RS12550	COG0700	Nucleoside recognition
HWV68_RS12555	COG2715	membrane protein required for spore maturation
HWV68_RS12560	COG1686	Belongs to the peptidase S11 family
HWV68_RS12570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWV68_RS12575	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWV68_RS12580	COG1547	Domain of unknown function (DUF309)
HWV68_RS12585	COG0456	acetyltransferase
HWV68_RS12590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HWV68_RS12595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV68_RS12595	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV68_RS12600	COG0307	riboflavin synthase, alpha
HWV68_RS12605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV68_RS12605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV68_RS12615	COG0681	Belongs to the peptidase S26 family
HWV68_RS12625	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HWV68_RS12640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWV68_RS12645	COG4086	secreted protein
HWV68_RS12650	COG0019	diaminopimelate decarboxylase activity
HWV68_RS12655	COG0697	spore germination
HWV68_RS12670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_RS12690	COG1191	sigma factor activity
HWV68_RS12695	COG2172	sigma factor antagonist activity
HWV68_RS12700	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS12705	COG1686	Belongs to the peptidase S11 family
HWV68_RS12710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HWV68_RS12715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HWV68_RS12720	COG4974	Belongs to the 'phage' integrase family
HWV68_RS12730	COG0735	belongs to the Fur family
HWV68_RS12735	COG1300	Membrane
HWV68_RS12745	COG0281	malic enzyme
HWV68_RS12750	COG1757	Na H antiporter
HWV68_RS12755	COG1027	Aspartate ammonia-lyase
HWV68_RS12760	COG0252	asparaginase activity
HWV68_RS12765	COG1396	sequence-specific DNA binding
HWV68_RS12770	COG1379	DNA repair
HWV68_RS12775	COG0494	nUDIX hydrolase
HWV68_RS12785	COG0667	Aldo Keto reductase
HWV68_RS12795	COG1073	alpha beta
HWV68_RS12805	COG4918	Iron-sulphur cluster biosynthesis
HWV68_RS12810	COG0456	acetyltransferase
HWV68_RS12810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWV68_RS12815	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_RS12820	COG0456	acetyltransferase
HWV68_RS12830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_RS12840	COG2211	Major facilitator Superfamily
HWV68_RS12850	COG0346	lactoylglutathione lyase activity
HWV68_RS12855	COG1072	(Pantothenic acid kinase))
HWV68_RS12860	COG3048	D-serine ammonia-lyase activity
HWV68_RS12865	COG0300	oxidoreductase activity
HWV68_RS12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS12875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_RS12880	COG4187	Peptidase family M20/M25/M40
HWV68_RS12885	COG1902	pentaerythritol trinitrate reductase activity
HWV68_RS12890	COG0596	Alpha beta hydrolase
HWV68_RS12900	COG1234	tRNA 3'-trailer cleavage
HWV68_RS12905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWV68_RS12910	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWV68_RS12915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_RS12925	COG0706	membrane insertase activity
HWV68_RS12930	COG3361	conserved protein (COG2071)
HWV68_RS12935	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWV68_RS12940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWV68_RS12945	COG0346	lactoylglutathione lyase activity
HWV68_RS12955	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_RS12960	COG4129	membrane
HWV68_RS12965	COG1126	abc transporter atp-binding protein
HWV68_RS12970	COG0765	amino acid transport
HWV68_RS12975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS12985	COG1597	lipid kinase activity
HWV68_RS12990	COG2814	Major facilitator Superfamily
HWV68_RS12995	COG4978	Transcriptional regulator
HWV68_RS12995	COG0789	Transcriptional regulator
HWV68_RS13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_RS13005	COG0022	dehydrogenase e1 component
HWV68_RS13010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_RS13015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_RS13020	COG3426	butyrate kinase activity
HWV68_RS13025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_RS13030	COG0280	phosphate acetyltransferase
HWV68_RS13035	COG3290	protein histidine kinase activity
HWV68_RS13035	COG3829	transcription factor binding
HWV68_RS13045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWV68_RS13050	COG2079	MmgE PrpD family protein
HWV68_RS13055	COG0372	Belongs to the citrate synthase family
HWV68_RS13060	COG1960	acyl-CoA dehydrogenase activity
HWV68_RS13065	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWV68_RS13070	COG0183	Belongs to the thiolase family
HWV68_RS13075	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_RS13080	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS13095	COG1902	pentaerythritol trinitrate reductase activity
HWV68_RS13100	COG0745	RESPONSE REGULATOR receiver
HWV68_RS13105	COG0750	zinc metalloprotease
HWV68_RS13110	COG0497	DNA recombination
HWV68_RS13115	COG1438	arginine binding
HWV68_RS13120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HWV68_RS13125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HWV68_RS13130	COG0142	geranyltranstransferase activity
HWV68_RS13135	COG1722	exodeoxyribonuclease VII activity
HWV68_RS13140	COG1570	exodeoxyribonuclease VII activity
HWV68_RS13145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWV68_RS13150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV68_RS13155	COG1302	Protein conserved in bacteria
HWV68_RS13160	COG0439	Biotin carboxylase
HWV68_RS13165	COG0511	ligase activity, forming carbon-carbon bonds
HWV68_RS13205	COG3854	ATPases associated with a variety of cellular activities
HWV68_RS13215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWV68_RS13220	COG0006	proline dipeptidase activity
HWV68_RS13225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWV68_RS13235	COG3872	metal-dependent enzyme
HWV68_RS13245	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWV68_RS13250	COG1321	iron dependent repressor
HWV68_RS13255	COG0095	Lipoate-protein ligase
HWV68_RS13260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_RS13265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV68_RS13270	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV68_RS13275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWV68_RS13280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWV68_RS13295	COG1396	sequence-specific DNA binding
HWV68_RS13305	COG0681	Belongs to the peptidase S26 family
HWV68_RS13330	COG4940	Competence protein ComGF
HWV68_RS13340	COG4970	Tfp pilus assembly protein FimT
HWV68_RS13345	COG4537	Required for transformation and DNA binding
HWV68_RS13350	COG1459	type II secretion system
HWV68_RS13355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWV68_RS13360	COG0598	Magnesium transport protein CorA
HWV68_RS13365	COG1253	flavin adenine dinucleotide binding
HWV68_RS13370	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS13380	COG1393	Belongs to the ArsC family
HWV68_RS13390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS13400	COG0011	TIGRFAM Protein of
HWV68_RS13410	COG2866	Carboxypeptidase
HWV68_RS13415	COG1368	sulfuric ester hydrolase activity
HWV68_RS13420	COG1940	carbohydrate kinase activity
HWV68_RS13425	COG4483	Protein conserved in bacteria
HWV68_RS13430	COG0457	Tetratricopeptide repeat
HWV68_RS13430	COG0705	Rhomboid family
HWV68_RS13440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWV68_RS13450	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS13465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWV68_RS13470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_RS13475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_RS13480	COG0581	inorganic phosphate transmembrane transporter activity
HWV68_RS13485	COG0573	inorganic phosphate transmembrane transporter activity
HWV68_RS13490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWV68_RS13500	COG0477	Major facilitator Superfamily
HWV68_RS13505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWV68_RS13510	COG2839	Protein conserved in bacteria
HWV68_RS13515	COG5521	maltodextrose utilization protein MalA
HWV68_RS13525	COG1388	LysM domain
HWV68_RS13530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HWV68_RS13535	COG4709	membrane
HWV68_RS13540	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HWV68_RS13545	COG0735	belongs to the Fur family
HWV68_RS13550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS13560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HWV68_RS13565	COG0513	Belongs to the DEAD box helicase family
HWV68_RS13575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HWV68_RS13580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWV68_RS13585	COG2384	SAM-dependent methyltransferase
HWV68_RS13590	COG2010	Cytochrome c
HWV68_RS13595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWV68_RS13600	COG0358	DNA primase activity
HWV68_RS13605	COG1671	Belongs to the UPF0178 family
HWV68_RS13610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HWV68_RS13615	COG0517	IMP dehydrogenase activity
HWV68_RS13620	COG0751	glycine-tRNA ligase activity
HWV68_RS13625	COG0752	glycyl-tRNA synthetase alpha subunit
HWV68_RS13630	COG1381	Involved in DNA repair and RecF pathway recombination
HWV68_RS13640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWV68_RS13645	COG0295	cytidine deaminase activity
HWV68_RS13650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HWV68_RS13655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HWV68_RS13660	COG1480	7TM receptor with intracellular HD hydrolase
HWV68_RS13665	COG1702	phosphate starvation-inducible protein PhoH
HWV68_RS13670	COG0561	phosphatase activity
HWV68_RS13685	COG4864	UPF0365 protein
HWV68_RS13690	COG1030	water channel activity
HWV68_RS13695	COG1610	YqeY-like protein
HWV68_RS13705	COG1283	sodium-dependent phosphate transmembrane transporter activity
HWV68_RS13710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV68_RS13715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWV68_RS13720	COG2264	protein methyltransferase activity
HWV68_RS13725	COG0484	heat shock protein binding
HWV68_RS13730	COG0443	Heat shock 70 kDa protein
HWV68_RS13735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWV68_RS13740	COG1420	regulation of RNA biosynthetic process
HWV68_RS13745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWV68_RS13750	COG0481	GTPase activity
HWV68_RS13760	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS13765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HWV68_RS13770	COG0268	Binds directly to 16S ribosomal RNA
HWV68_RS13775	COG1466	dna polymerase III delta subunit
HWV68_RS13790	COG2333	competence protein COMEC
HWV68_RS13790	COG0658	competence protein
HWV68_RS13795	COG2131	deaminase
HWV68_RS13800	COG1596	polysaccharide export
HWV68_RS13800	COG1555	photosystem II stabilization
HWV68_RS13805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_RS13810	COG2226	methyltransferase
HWV68_RS13815	COG0799	negative regulation of ribosome biogenesis
HWV68_RS13820	COG1713	HD superfamily hydrolase involved in NAD metabolism
HWV68_RS13825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWV68_RS13830	COG1534	Rna-binding protein
HWV68_RS13835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWV68_RS13840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWV68_RS13845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HWV68_RS13855	COG2755	lipolytic protein G-D-S-L family
HWV68_RS13860	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS13860	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS13865	COG0398	Pfam SNARE associated Golgi protein
HWV68_RS13870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HWV68_RS13880	COG3209	COG3209 Rhs family protein
HWV68_RS13890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_RS13895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_RS13900	COG0798	PFAM Bile acid sodium symporter
HWV68_RS13905	COG0346	lactoylglutathione lyase activity
HWV68_RS13910	COG0640	Transcriptional regulator
HWV68_RS13915	COG3403	YqcI/YcgG family
HWV68_RS13920	COG0457	Tetratricopeptide repeat
HWV68_RS13935	COG5444	nuclease activity
HWV68_RS13960	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS13960	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS13965	COG4824	toxin secretion phage lysis holin
HWV68_RS13995	COG3778	Protein conserved in bacteria
HWV68_RS14000	COG3299	homolog of phage Mu protein gp47
HWV68_RS14005	COG3628	GPW Gp25 family protein
HWV68_RS14015	COG4193	domain, Protein
HWV68_RS14020	COG1652	LysM domain
HWV68_RS14025	COG3953	SLT domain
HWV68_RS14025	COG5280	Phage tail tape measure protein TP901
HWV68_RS14090	COG4653	Phage capsid family
HWV68_RS14095	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HWV68_RS14105	COG2369	cell adhesion
HWV68_RS14110	COG5518	Phage portal protein
HWV68_RS14115	COG1783	phage Terminase large subunit
HWV68_RS14120	COG5484	DNA packaging
HWV68_RS14130	COG3677	Transposase
HWV68_RS14145	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HWV68_RS14155	COG1484	DNA-dependent DNA replication
HWV68_RS14160	COG3935	DnaD domain protein
HWV68_RS14165	COG3723	Recombinational DNA repair protein, rece pathway
HWV68_RS14170	COG5377	YqaJ viral recombinase family
HWV68_RS14200	COG1476	TRANSCRIPTIONal
HWV68_RS14205	COG3620	sequence-specific DNA binding
HWV68_RS14215	COG0563	adenylate kinase activity
HWV68_RS14220	COG2856	Zn peptidase
HWV68_RS14245	COG3223	Belongs to the PsiE family
HWV68_RS14250	COG0642	Histidine kinase
HWV68_RS14250	COG5002	protein histidine kinase activity
HWV68_RS14255	COG0745	RESPONSE REGULATOR receiver
HWV68_RS14260	COG2311	Membrane
HWV68_RS14270	COG0454	-acetyltransferase
HWV68_RS14275	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_RS14285	COG0730	response to heat
HWV68_RS14290	COG0425	Belongs to the sulfur carrier protein TusA family
HWV68_RS14295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS14295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_RS14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_RS14305	COG0425	Belongs to the sulfur carrier protein TusA family
HWV68_RS14310	COG2210	Belongs to the sulfur carrier protein TusA family
HWV68_RS14315	COG1937	Protein conserved in bacteria
HWV68_RS14320	COG0662	Cupin 2, conserved barrel domain protein
HWV68_RS14330	COG0789	Transcriptional regulator
HWV68_RS14330	COG4978	Transcriptional regulator
HWV68_RS14335	COG2814	Major facilitator Superfamily
HWV68_RS14340	COG0456	acetyltransferase
HWV68_RS14345	COG1253	flavin adenine dinucleotide binding
HWV68_RS14355	COG0697	spore germination
HWV68_RS14360	COG0583	DNA-binding transcription factor activity
HWV68_RS14365	COG2072	flavoprotein involved in K transport
HWV68_RS14370	COG1230	cation diffusion facilitator family transporter
HWV68_RS14375	COG1942	4-Oxalocrotonate Tautomerase
HWV68_RS14380	COG0583	DNA-binding transcription factor activity
HWV68_RS14390	COG1114	Component of the transport system for branched-chain amino acids
HWV68_RS14395	COG1687	branched-chain amino acid
HWV68_RS14400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWV68_RS14405	COG1522	sequence-specific DNA binding
HWV68_RS14410	COG2732	(Barnase) inhibitor
HWV68_RS14415	COG2124	cytochrome p450
HWV68_RS14425	COG1335	isochorismatase
HWV68_RS14440	COG2318	DinB family
HWV68_RS14450	COG2070	2-Nitropropane dioxygenase
HWV68_RS14455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWV68_RS14475	COG3443	Belongs to the bacterial solute-binding protein 9 family
HWV68_RS14480	COG1595	DNA-templated transcription, initiation
HWV68_RS14485	COG0667	Aldo Keto reductase
HWV68_RS14490	COG2851	Citrate transporter
HWV68_RS14495	COG0583	DNA-binding transcription factor activity
HWV68_RS14500	COG2828	Protein conserved in bacteria
HWV68_RS14505	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS14510	COG5566	PFAM Mor transcription activator
HWV68_RS14515	COG0596	Alpha beta hydrolase
HWV68_RS14520	COG4991	sh3 domain protein
HWV68_RS14525	COG4991	sh3 domain protein
HWV68_RS14535	COG0346	lactoylglutathione lyase activity
HWV68_RS14545	COG5577	PFAM Coat F domain
HWV68_RS14550	COG1063	alcohol dehydrogenase
HWV68_RS14560	COG5577	PFAM Coat F domain
HWV68_RS14565	COG0789	Transcriptional regulator
HWV68_RS14575	COG1064	alcohol dehydrogenase
HWV68_RS14580	COG0693	protein deglycase activity
HWV68_RS14585	COG1621	beta-fructofuranosidase activity
HWV68_RS14590	COG3716	PTS system mannose fructose sorbose family IID component
HWV68_RS14595	COG3715	PTS system
HWV68_RS14600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS14605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS14610	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HWV68_RS14610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HWV68_RS14620	COG1113	amino acid transport
HWV68_RS14625	COG1280	lysine exporter protein (LysE YggA)
HWV68_RS14630	COG1378	Sugar-specific transcriptional regulator TrmB
HWV68_RS14635	COG1595	DNA-templated transcription, initiation
HWV68_RS14645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWV68_RS14645	COG2755	lipolytic protein G-D-S-L family
HWV68_RS14655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_RS14655	COG2124	cytochrome p450
HWV68_RS14660	COG1309	transcriptional regulator
HWV68_RS14665	COG2226	methyltransferase
HWV68_RS14680	COG2116	formate transmembrane transporter activity
HWV68_RS14685	COG5609	conserved protein (DUF2294)
HWV68_RS14690	COG3383	formate dehydrogenase (NAD+) activity
HWV68_RS14695	COG2427	Protein of unknown function (DUF1641)
HWV68_RS14705	COG0626	cystathionine gamma-synthase activity
HWV68_RS14710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_RS14715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWV68_RS14720	COG2226	methyltransferase
HWV68_RS14735	COG0768	penicillin binding
HWV68_RS14740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWV68_RS14745	COG0572	uridine kinase
HWV68_RS14760	COG4122	O-methyltransferase activity
HWV68_RS14765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWV68_RS14770	COG3906	Belongs to the UPF0473 family
HWV68_RS14775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWV68_RS14780	COG4472	Bacterial protein of unknown function (DUF965)
HWV68_RS14785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWV68_RS14790	COG0628	permease
HWV68_RS14795	COG1126	abc transporter atp-binding protein
HWV68_RS14800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS14805	COG0765	amino acid transport
HWV68_RS14810	COG0765	amino acid transport
HWV68_RS14825	COG3881	PFAM PRC-barrel domain
HWV68_RS14830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWV68_RS14835	COG0457	Tetratricopeptide repeat
HWV68_RS14840	COG0482	sulfurtransferase activity
HWV68_RS14845	COG1104	cysteine desulfurase activity
HWV68_RS14850	COG1959	2 iron, 2 sulfur cluster binding
HWV68_RS14855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWV68_RS14860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWV68_RS14870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWV68_RS14875	COG0124	histidyl-tRNA synthetase
HWV68_RS14885	COG4991	sh3 domain protein
HWV68_RS14885	COG3103	Sh3 type 3 domain protein
HWV68_RS14885	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS14890	COG1490	D-aminoacyl-tRNA deacylase activity
HWV68_RS14895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWV68_RS14900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_RS14905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWV68_RS14905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HWV68_RS14910	COG5416	Lipopolysaccharide assembly protein A domain
HWV68_RS14915	COG0490	domain, Protein
HWV68_RS14920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWV68_RS14920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWV68_RS14930	COG2244	polysaccharide biosynthetic process
HWV68_RS14935	COG2323	membrane
HWV68_RS14945	COG1862	Preprotein translocase
HWV68_RS14950	COG0343	queuine tRNA-ribosyltransferase activity
HWV68_RS14955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HWV68_RS14965	COG2255	four-way junction helicase activity
HWV68_RS14970	COG0632	four-way junction helicase activity
HWV68_RS14980	COG2814	Major facilitator Superfamily
HWV68_RS14985	COG0673	inositol 2-dehydrogenase activity
HWV68_RS14990	COG2112	serine threonine protein kinase
HWV68_RS15010	COG1115	amino acid carrier protein
HWV68_RS15015	COG0217	transcriptional regulatory protein
HWV68_RS15025	COG1388	LysM domain
HWV68_RS15030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWV68_RS15035	COG0157	Belongs to the NadC ModD family
HWV68_RS15040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWV68_RS15045	COG1104	cysteine desulfurase activity
HWV68_RS15050	COG1827	regulation of RNA biosynthetic process
HWV68_RS15055	COG0077	Prephenate dehydratase
HWV68_RS15060	COG4492	Belongs to the UPF0735 family
HWV68_RS15065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWV68_RS15070	COG3290	protein histidine kinase activity
HWV68_RS15080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWV68_RS15085	COG2868	ribosomal protein
HWV68_RS15090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HWV68_RS15095	COG1994	Peptidase M50
HWV68_RS15100	COG0739	heme binding
HWV68_RS15105	COG2894	cell division
HWV68_RS15110	COG0850	regulation of cytokinetic process
HWV68_RS15115	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWV68_RS15125	COG1077	Cell shape determining protein MreB Mrl
HWV68_RS15130	COG2003	Belongs to the UPF0758 family
HWV68_RS15135	COG0424	maF-like protein
HWV68_RS15145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HWV68_RS15150	COG0285	dihydrofolate synthase activity
HWV68_RS15155	COG0525	valine-tRNA ligase activity
HWV68_RS15165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_RS15170	COG1388	LysM domain
HWV68_RS15175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWV68_RS15180	COG0113	porphobilinogen synthase activity
HWV68_RS15185	COG1587	Uroporphyrinogen-III synthase
HWV68_RS15190	COG0181	hydroxymethylbilane synthase activity
HWV68_RS15195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV68_RS15200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HWV68_RS15210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HWV68_RS15215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWV68_RS15220	COG1067	ATP-dependent peptidase activity
HWV68_RS15220	COG0470	DNA polymerase III
HWV68_RS15225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HWV68_RS15230	COG0544	peptidyl-prolyl cis-trans isomerase activity
HWV68_RS15235	COG0457	Tetratricopeptide repeat
HWV68_RS15235	COG1477	protein flavinylation
HWV68_RS15240	COG0066	3-isopropylmalate dehydratase activity
HWV68_RS15245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HWV68_RS15250	COG0473	3-isopropylmalate dehydrogenase activity
HWV68_RS15255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWV68_RS15260	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWV68_RS15265	COG0440	acetolactate synthase activity
HWV68_RS15270	COG0028	Belongs to the TPP enzyme family
HWV68_RS15280	COG0454	-acetyltransferase
HWV68_RS15285	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HWV68_RS15295	COG0622	Phosphoesterase
HWV68_RS15300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWV68_RS15305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HWV68_RS15310	COG5401	PFAM Sporulation and spore germination
HWV68_RS15315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWV68_RS15320	COG1846	Transcriptional regulator
HWV68_RS15325	COG2197	response regulator
HWV68_RS15330	COG0824	Thioesterase
HWV68_RS15335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWV68_RS15340	COG1053	succinate dehydrogenase
HWV68_RS15345	COG2009	succinate dehydrogenase
HWV68_RS15350	COG1719	4-vinyl reductase, 4VR
HWV68_RS15355	COG0527	aspartate kinase activity
HWV68_RS15360	COG0322	excinuclease ABC activity
HWV68_RS15365	COG3118	belongs to the thioredoxin family
HWV68_RS15370	COG3534	alpha-L-arabinofuranosidase
HWV68_RS15375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HWV68_RS15380	COG2086	electron transfer activity
HWV68_RS15385	COG1024	Enoyl-CoA hydratase
HWV68_RS15390	COG1309	transcriptional regulator
HWV68_RS15395	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS15400	COG3766	membrane
HWV68_RS15405	COG1193	negative regulation of DNA recombination
HWV68_RS15410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWV68_RS15410	COG1796	DNA polymerase
HWV68_RS15415	COG1286	toxin biosynthetic process
HWV68_RS15420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HWV68_RS15425	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWV68_RS15430	COG0072	phenylalanine-tRNA ligase activity
HWV68_RS15430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_RS15435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWV68_RS15445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWV68_RS15455	COG3835	regulator
HWV68_RS15460	COG0277	FAD linked oxidase domain protein
HWV68_RS15465	COG0247	lactate metabolic process
HWV68_RS15470	COG0346	lactoylglutathione lyase activity
HWV68_RS15480	COG1966	Carbon starvation protein
HWV68_RS15485	COG3534	alpha-L-arabinofuranosidase
HWV68_RS15490	COG0395	ABC-type sugar transport system, permease component
HWV68_RS15495	COG1175	transmembrane transport
HWV68_RS15500	COG1653	transport
HWV68_RS15505	COG0371	Dehydrogenase
HWV68_RS15510	COG0647	UMP catabolic process
HWV68_RS15515	COG0235	Class ii aldolase
HWV68_RS15520	COG1069	ribulokinase activity
HWV68_RS15525	COG2160	L-arabinose isomerase activity
HWV68_RS15530	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_RS15535	COG1363	Peptidase, m42
HWV68_RS15545	COG3326	Membrane
HWV68_RS15550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWV68_RS15555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HWV68_RS15560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWV68_RS15570	COG1346	cytolysis
HWV68_RS15575	COG1380	Effector of murein hydrolase LrgA
HWV68_RS15580	COG3279	Response regulator of the LytR AlgR family
HWV68_RS15585	COG3275	phosphorelay sensor kinase activity
HWV68_RS15590	COG1011	Hydrolase
HWV68_RS15595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWV68_RS15605	COG0398	Pfam SNARE associated Golgi protein
HWV68_RS15610	COG1484	DNA-dependent DNA replication
HWV68_RS15615	COG3611	Membrane attachment protein
HWV68_RS15620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWV68_RS15625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HWV68_RS15630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWV68_RS15635	COG1733	regulation of RNA biosynthetic process
HWV68_RS15640	COG2814	Major facilitator Superfamily
HWV68_RS15645	COG0656	L-ascorbic acid biosynthetic process
HWV68_RS15650	COG0237	dephospho-CoA kinase activity
HWV68_RS15655	COG1971	Probably functions as a manganese efflux pump
HWV68_RS15660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWV68_RS15665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_RS15665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_RS15670	COG5002	protein histidine kinase activity
HWV68_RS15675	COG0745	RESPONSE REGULATOR receiver
HWV68_RS15680	COG0039	L-malate dehydrogenase activity
HWV68_RS15685	COG0538	isocitrate dehydrogenase activity
HWV68_RS15690	COG0372	Belongs to the citrate synthase family
HWV68_RS15695	COG2707	UPF0756 membrane protein
HWV68_RS15700	COG0628	permease
HWV68_RS15705	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWV68_RS15710	COG0469	pyruvate kinase activity
HWV68_RS15715	COG0205	6-phosphofructokinase activity
HWV68_RS15720	COG0825	malonyl-CoA metabolic process
HWV68_RS15725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HWV68_RS15730	COG0281	malic enzyme
HWV68_RS15735	COG0587	DNA-directed DNA polymerase activity
HWV68_RS15755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HWV68_RS15765	COG4109	DRTGG domain
HWV68_RS15770	COG0730	response to heat
HWV68_RS15775	COG1473	amidohydrolase
HWV68_RS15780	COG0196	riboflavin kinase activity
HWV68_RS15785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS15790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWV68_RS15795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS15800	COG1126	abc transporter atp-binding protein
HWV68_RS15805	COG0765	amino acid transport
HWV68_RS15810	COG0765	amino acid transport
HWV68_RS15815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS15820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS15825	COG0454	-acetyltransferase
HWV68_RS15830	COG0583	DNA-binding transcription factor activity
HWV68_RS15835	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWV68_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS15845	COG0165	Argininosuccinate lyase
HWV68_RS15850	COG0137	argininosuccinate synthase activity
HWV68_RS15855	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWV68_RS15860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWV68_RS15870	COG0827	DNA restriction-modification system
HWV68_RS15875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HWV68_RS15880	COG3874	Sporulation protein YtfJ
HWV68_RS15890	COG1714	RDD family
HWV68_RS15895	COG0616	signal peptide processing
HWV68_RS15900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWV68_RS15905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HWV68_RS15910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWV68_RS15920	COG0301	tRNA thio-modification
HWV68_RS15925	COG1104	cysteine desulfurase activity
HWV68_RS15930	COG1114	Component of the transport system for branched-chain amino acids
HWV68_RS15935	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HWV68_RS15940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWV68_RS15945	COG1309	transcriptional regulator
HWV68_RS15950	COG1956	GAF domain-containing protein
HWV68_RS15955	COG2203	Gaf domain
HWV68_RS15955	COG2199	diguanylate cyclase activity
HWV68_RS15960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HWV68_RS15965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWV68_RS15970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWV68_RS15975	COG0454	-acetyltransferase
HWV68_RS15980	COG0517	IMP dehydrogenase activity
HWV68_RS15985	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWV68_RS15990	COG1360	Flagellar Motor Protein
HWV68_RS15995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWV68_RS16000	COG1609	Transcriptional regulator
HWV68_RS16005	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HWV68_RS16005	COG1605	Chorismate mutase
HWV68_RS16010	COG3118	belongs to the thioredoxin family
HWV68_RS16015	COG4980	gas vesicle protein
HWV68_RS16020	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWV68_RS16025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWV68_RS16030	COG1674	ftsk spoiiie
HWV68_RS16035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_RS16040	COG4848	Belongs to the UPF0354 family
HWV68_RS16045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS16060	COG1363	Peptidase, m42
HWV68_RS16065	COG5584	Small secreted protein
HWV68_RS16070	COG0281	malic enzyme
HWV68_RS16075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS16080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWV68_RS16090	COG0510	thiamine kinase activity
HWV68_RS16095	COG1523	belongs to the glycosyl hydrolase 13 family
HWV68_RS16100	COG1597	lipid kinase activity
HWV68_RS16110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWV68_RS16115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_RS16120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_RS16125	COG2252	PERMEase
HWV68_RS16130	COG4473	ABC transporter
HWV68_RS16135	COG1131	(ABC) transporter
HWV68_RS16140	COG1349	DNA-binding transcription factor activity
HWV68_RS16145	COG1187	pseudouridine synthase activity
HWV68_RS16150	COG2244	polysaccharide biosynthetic process
HWV68_RS16155	COG2081	HI0933 family
HWV68_RS16160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWV68_RS16170	COG5578	integral membrane protein
HWV68_RS16175	COG0673	inositol 2-dehydrogenase activity
HWV68_RS16180	COG1653	transport
HWV68_RS16185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HWV68_RS16190	COG4209	transmembrane transport
HWV68_RS16195	COG2207	Transcriptional regulator
HWV68_RS16200	COG1653	transport
HWV68_RS16205	COG0395	ABC-type sugar transport system, permease component
HWV68_RS16210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_RS16215	COG2124	cytochrome p450
HWV68_RS16220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HWV68_RS16225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HWV68_RS16230	COG0156	8-amino-7-oxononanoate synthase activity
HWV68_RS16235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_RS16240	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HWV68_RS16245	COG1073	alpha beta
HWV68_RS16250	COG1609	Transcriptional regulator
HWV68_RS16255	COG1653	transport
HWV68_RS16260	COG1175	transmembrane transport
HWV68_RS16265	COG0395	ABC-type sugar transport system, permease component
HWV68_RS16270	COG1486	melibiose metabolic process
HWV68_RS16275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_RS16280	COG0495	leucyl-tRNA aminoacylation
HWV68_RS16290	COG2202	Pas domain
HWV68_RS16290	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_RS16295	COG2814	Major facilitator Superfamily
HWV68_RS16300	COG2433	Pfam Transposase IS66
HWV68_RS16305	COG0577	efflux transmembrane transporter activity
HWV68_RS16310	COG1136	(ABC) transporter
HWV68_RS16315	COG2205	protein histidine kinase activity
HWV68_RS16320	COG0745	RESPONSE REGULATOR receiver
HWV68_RS16325	COG0577	efflux transmembrane transporter activity
HWV68_RS16330	COG1136	(ABC) transporter
HWV68_RS16345	COG1131	(ABC) transporter
HWV68_RS16350	COG1725	Transcriptional regulator
HWV68_RS16365	COG1242	4 iron, 4 sulfur cluster binding
HWV68_RS16370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HWV68_RS16380	COG2267	carboxylic ester hydrolase activity
HWV68_RS16385	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWV68_RS16390	COG1113	amino acid transport
HWV68_RS16395	COG0367	asparagine synthase
HWV68_RS16400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HWV68_RS16405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HWV68_RS16415	COG1506	peptidase
HWV68_RS16420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWV68_RS16425	COG1116	anion transmembrane transporter activity
HWV68_RS16430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWV68_RS16435	COG0494	nUDIX hydrolase
HWV68_RS16440	COG4824	toxin secretion phage lysis holin
HWV68_RS16445	COG0783	Belongs to the Dps family
HWV68_RS16460	COG1854	S-ribosylhomocysteine lyase activity
HWV68_RS16465	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HWV68_RS16470	COG0288	reversible hydration of carbon dioxide
HWV68_RS16475	COG0254	rRNA binding
HWV68_RS16480	COG1271	oxidase subunit
HWV68_RS16485	COG1294	oxidase, subunit
HWV68_RS16495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_RS16500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_RS16500	COG1321	iron dependent repressor
HWV68_RS16505	COG1121	(ABC) transporter
HWV68_RS16510	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWV68_RS16515	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_RS16520	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_RS16525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HWV68_RS16530	COG0596	Alpha beta hydrolase
HWV68_RS16535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HWV68_RS16540	COG1169	isochorismate synthase
HWV68_RS16545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_RS16550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_RS16555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_RS16560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_RS16565	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS16575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_RS16580	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS16585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_RS16590	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HWV68_RS16595	COG0058	SHG alpha-glucan phosphorylase activity
HWV68_RS16600	COG0297	glycogen (starch) synthase activity
HWV68_RS16605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HWV68_RS16610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HWV68_RS16615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWV68_RS16740	COG3859	Proton-coupled thiamine transporter YuaJ
HWV68_RS16745	COG1247	-acetyltransferase
HWV68_RS16750	COG2268	Band 7 protein
HWV68_RS16755	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWV68_RS16760	COG2318	DinB family
HWV68_RS16770	COG1454	alcohol dehydrogenase
HWV68_RS16775	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS16780	COG1510	regulation of RNA biosynthetic process
HWV68_RS16790	COG0569	domain protein
HWV68_RS16795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWV68_RS16800	COG4682	membrane
HWV68_RS16805	COG1705	Flagellar rod assembly protein muramidase FlgJ
HWV68_RS16810	COG0477	Major facilitator Superfamily
HWV68_RS16815	COG5553	Cysteine dioxygenase type I
HWV68_RS16825	COG1968	undecaprenyl-diphosphatase activity
HWV68_RS16830	COG0628	permease
HWV68_RS16835	COG0673	inositol 2-dehydrogenase activity
HWV68_RS16840	COG4806	L-rhamnose isomerase
HWV68_RS16845	COG3254	rhamnose metabolic process
HWV68_RS16850	COG1070	Carbohydrate kinase
HWV68_RS16855	COG1349	DNA-binding transcription factor activity
HWV68_RS16860	COG3347	Dehydrogenase
HWV68_RS16860	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS16865	COG0840	transmembrane signaling receptor activity
HWV68_RS16870	COG0840	transmembrane signaling receptor activity
HWV68_RS16875	COG0840	transmembrane signaling receptor activity
HWV68_RS16880	COG0840	transmembrane signaling receptor activity
HWV68_RS16895	COG0432	Pfam Uncharacterised protein family UPF0047
HWV68_RS16905	COG0366	Alpha amylase catalytic
HWV68_RS16910	COG1253	flavin adenine dinucleotide binding
HWV68_RS16915	COG2738	Putative neutral zinc metallopeptidase
HWV68_RS16930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWV68_RS16945	COG0166	Belongs to the GPI family
HWV68_RS16950	COG1979	alcohol dehydrogenase
HWV68_RS16955	COG1979	alcohol dehydrogenase
HWV68_RS16960	COG2155	Conserved Protein
HWV68_RS16965	COG1098	S1 RNA binding domain
HWV68_RS16970	COG0436	Aminotransferase
HWV68_RS16975	COG1522	sequence-specific DNA binding
HWV68_RS16980	COG2267	carboxylic ester hydrolase activity
HWV68_RS16990	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HWV68_RS16995	COG2205	protein histidine kinase activity
HWV68_RS17005	COG5018	Exonuclease
HWV68_RS17010	COG2814	Major facilitator Superfamily
HWV68_RS17015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_RS17020	COG3011	Protein conserved in bacteria
HWV68_RS17030	COG3290	protein histidine kinase activity
HWV68_RS17035	COG4565	transcriptional regulatory protein
HWV68_RS17060	COG3493	citrate carrier protein
HWV68_RS17070	COG2111	Na H antiporter
HWV68_RS17070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWV68_RS17075	COG2111	Na H antiporter
HWV68_RS17080	COG1006	Multisubunit Na H antiporter MnhC subunit
HWV68_RS17085	COG0651	ATP synthesis coupled electron transport
HWV68_RS17090	COG1863	multisubunit Na H antiporter MnhE subunit
HWV68_RS17095	COG2212	antiporter activity
HWV68_RS17100	COG1320	monovalent cation:proton antiporter activity
HWV68_RS17105	COG2050	protein possibly involved in aromatic compounds catabolism
HWV68_RS17110	COG2197	response regulator
HWV68_RS17115	COG4585	Histidine kinase
HWV68_RS17125	COG0142	geranyltranstransferase activity
HWV68_RS17145	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HWV68_RS17150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HWV68_RS17155	COG1335	isochorismatase
HWV68_RS17160	COG5506	Protein of unknown function (DUF1694)
HWV68_RS17175	COG0628	permease
HWV68_RS17190	COG1418	mRNA catabolic process
HWV68_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS17205	COG1511	domain protein
HWV68_RS17210	COG0433	COG0433 Predicted ATPase
HWV68_RS17210	COG1674	ftsk spoiiie
HWV68_RS17215	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWV68_RS17220	COG5417	Belongs to the EsaB family
HWV68_RS17225	COG4842	Belongs to the WXG100 family
HWV68_RS17230	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWV68_RS17230	COG2508	Transcriptional regulator
HWV68_RS17235	COG0686	Belongs to the AlaDH PNT family
HWV68_RS17240	COG5634	Uncharacterized conserved protein (DUF2278)
HWV68_RS17245	COG3251	PFAM MbtH domain protein
HWV68_RS17250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS17255	COG1535	isochorismatase
HWV68_RS17255	COG3433	isochorismatase activity
HWV68_RS17260	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWV68_RS17265	COG1169	isochorismate synthase
HWV68_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS17275	COG2819	hydrolase of the alpha beta superfamily
HWV68_RS17280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWV68_RS17285	COG1268	BioY protein
HWV68_RS17290	COG2056	Na+-H+ antiporter family
HWV68_RS17295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HWV68_RS17300	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HWV68_RS17305	COG3584	3D domain protein
HWV68_RS17320	COG1252	NADH dehydrogenase
HWV68_RS17325	COG0492	ferredoxin-NADP+ reductase activity
HWV68_RS17335	COG0516	GMP reductase activity
HWV68_RS17340	COG2808	Putative FMN-binding domain
HWV68_RS17345	COG0456	acetyltransferase
HWV68_RS17350	COG0316	Belongs to the HesB IscA family
HWV68_RS17355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWV68_RS17360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_RS17365	COG4844	belongs to the
HWV68_RS17370	COG1252	NADH dehydrogenase
HWV68_RS17375	COG4837	Protein of unknown function (DUF1462)
HWV68_RS17380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HWV68_RS17385	COG1506	peptidase
HWV68_RS17385	COG4946	Tricorn protease homolog
HWV68_RS17385	COG0823	Involved in the tonB-independent uptake of proteins
HWV68_RS17390	COG0083	homoserine kinase activity
HWV68_RS17395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWV68_RS17400	COG0460	homoserine dehydrogenase
HWV68_RS17405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_RS17410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWV68_RS17415	COG0647	UMP catabolic process
HWV68_RS17420	COG2445	Protein of unknown function DUF86
HWV68_RS17425	COG4470	Protein conserved in bacteria
HWV68_RS17435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWV68_RS17440	COG0739	heme binding
HWV68_RS17450	COG3377	Domain of unknown function (DUF1805)
HWV68_RS17455	COG0737	Belongs to the 5'-nucleotidase family
HWV68_RS17460	COG0730	response to heat
HWV68_RS17465	COG1801	Protein of unknown function DUF72
HWV68_RS17475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV68_RS17480	COG2508	Transcriptional regulator
HWV68_RS17485	COG2233	PERMEase
HWV68_RS17490	COG2233	PERMEase
HWV68_RS17495	COG3195	allantoin biosynthetic process
HWV68_RS17495	COG3648	Uricase
HWV68_RS17500	COG2351	hydroxyisourate hydrolase activity
HWV68_RS17510	COG2080	2 iron, 2 sulfur cluster binding
HWV68_RS17515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWV68_RS17520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWV68_RS17525	COG2068	MobA-Related Protein
HWV68_RS17530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HWV68_RS17535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWV68_RS17540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_RS17550	COG2356	endonuclease I
HWV68_RS17555	COG3842	ATPase activity
HWV68_RS17560	COG2188	Transcriptional regulator
HWV68_RS17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_RS17570	COG0395	ABC-type sugar transport system, permease component
HWV68_RS17575	COG1175	transmembrane transport
HWV68_RS17580	COG1653	transport
HWV68_RS17585	COG2222	sugar isomerase
HWV68_RS17590	COG0322	excinuclease ABC activity
HWV68_RS17595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_RS17610	COG0346	lactoylglutathione lyase activity
HWV68_RS17615	COG0640	Transcriptional regulator
HWV68_RS17620	COG0719	Fe-S assembly protein
HWV68_RS17625	COG0822	iron-sulfur transferase activity
HWV68_RS17630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWV68_RS17635	COG0719	Fe-S assembly protein
HWV68_RS17640	COG0396	ATPase activity
HWV68_RS17650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWV68_RS17655	COG1464	Belongs to the NlpA lipoprotein family
HWV68_RS17660	COG2011	ABC-type metal ion transport system permease component
HWV68_RS17665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWV68_RS17675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_RS17680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWV68_RS17690	COG0509	glycine decarboxylation via glycine cleavage system
HWV68_RS17695	COG1393	Belongs to the ArsC family
HWV68_RS17700	COG1960	acyl-CoA dehydrogenase activity
HWV68_RS17705	COG0183	Belongs to the thiolase family
HWV68_RS17710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWV68_RS17710	COG1024	Enoyl-CoA hydratase
HWV68_RS17720	COG0506	proline dehydrogenase activity
HWV68_RS17730	COG5577	PFAM Coat F domain
HWV68_RS17735	COG1846	Transcriptional regulator
HWV68_RS17740	COG0477	Major facilitator Superfamily
HWV68_RS17745	COG1942	4-Oxalocrotonate Tautomerase
HWV68_RS17755	COG0583	DNA-binding transcription factor activity
HWV68_RS17765	COG1120	ATPase activity
HWV68_RS17780	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS17785	COG0783	Belongs to the Dps family
HWV68_RS17790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_RS17795	COG0745	RESPONSE REGULATOR receiver
HWV68_RS17800	COG2770	Histidine kinase
HWV68_RS17800	COG2205	protein histidine kinase activity
HWV68_RS17810	COG1309	transcriptional regulator
HWV68_RS17815	COG0114	fumarate hydratase activity
HWV68_RS17825	COG0697	spore germination
HWV68_RS17830	COG0814	amino acid
HWV68_RS17840	COG2197	response regulator
HWV68_RS17845	COG4585	Histidine kinase
HWV68_RS17850	COG4758	membrane
HWV68_RS17855	COG3595	metallopeptidase activity
HWV68_RS17860	COG1842	Phage shock protein A
HWV68_RS17865	COG4758	membrane
HWV68_RS17870	COG2814	Major facilitator Superfamily
HWV68_RS17875	COG2096	Adenosyltransferase
HWV68_RS17880	COG1120	ATPase activity
HWV68_RS17885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS17890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS17900	COG3386	PFAM SMP-30 Gluconolaconase
HWV68_RS17905	COG2205	protein histidine kinase activity
HWV68_RS17910	COG0745	RESPONSE REGULATOR receiver
HWV68_RS17920	COG1191	sigma factor activity
HWV68_RS17930	COG2140	Oxalate decarboxylase
HWV68_RS17940	COG0577	efflux transmembrane transporter activity
HWV68_RS17945	COG1136	(ABC) transporter
HWV68_RS17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWV68_RS17955	COG1120	ATPase activity
HWV68_RS17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_RS17970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS17975	COG0531	amino acid
HWV68_RS17985	COG1988	membrane-bound metal-dependent
HWV68_RS17990	COG1368	sulfuric ester hydrolase activity
HWV68_RS17995	COG1910	domain protein
HWV68_RS18000	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWV68_RS18005	COG4149	molybdate abc transporter
HWV68_RS18010	COG0656	L-ascorbic acid biosynthetic process
HWV68_RS18020	COG0025	NhaP-type Na H and K H
HWV68_RS18025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_RS18030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_RS18035	COG3973	AAA domain
HWV68_RS18040	COG2860	membrane
HWV68_RS18045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWV68_RS18050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWV68_RS18055	COG2217	Heavy metal translocating P-type atpase
HWV68_RS18060	COG2217	Heavy metal translocating P-type atpase
HWV68_RS18065	COG2608	mercury ion transmembrane transporter activity
HWV68_RS18070	COG1937	Protein conserved in bacteria
HWV68_RS18075	COG0673	inositol 2-dehydrogenase activity
HWV68_RS18080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWV68_RS18085	COG1289	transmembrane transporter activity
HWV68_RS18095	COG2076	Multidrug Resistance protein
HWV68_RS18100	COG1309	transcriptional regulator
HWV68_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS18115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HWV68_RS18120	COG0557	exoribonuclease II activity
HWV68_RS18125	COG1647	Serine aminopeptidase, S33
HWV68_RS18130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV68_RS18135	COG0596	Alpha beta hydrolase
HWV68_RS18140	COG1476	TRANSCRIPTIONal
HWV68_RS18145	COG1396	sequence-specific DNA binding
HWV68_RS18150	COG1396	sequence-specific DNA binding
HWV68_RS18155	COG1733	regulation of RNA biosynthetic process
HWV68_RS18160	COG0840	transmembrane signaling receptor activity
HWV68_RS18165	COG1174	glycine betaine transport
HWV68_RS18170	COG1732	Glycine betaine
HWV68_RS18175	COG1174	glycine betaine transport
HWV68_RS18180	COG1125	glycine betaine transport
HWV68_RS18180	COG0517	IMP dehydrogenase activity
HWV68_RS18185	COG1510	regulation of RNA biosynthetic process
HWV68_RS18205	COG5658	integral membrane protein
HWV68_RS18210	COG0640	Transcriptional regulator
HWV68_RS18215	COG1174	glycine betaine transport
HWV68_RS18220	COG1732	Glycine betaine
HWV68_RS18225	COG1174	glycine betaine transport
HWV68_RS18230	COG1125	glycine betaine transport
HWV68_RS18230	COG0517	IMP dehydrogenase activity
HWV68_RS18235	COG1510	regulation of RNA biosynthetic process
HWV68_RS18240	COG2095	MarC family integral membrane protein
HWV68_RS18250	COG3064	Membrane
HWV68_RS18255	COG4640	response to antibiotic
HWV68_RS18260	COG0456	acetyltransferase
HWV68_RS18265	COG0148	phosphopyruvate hydratase activity
HWV68_RS18270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HWV68_RS18275	COG0149	triose-phosphate isomerase activity
HWV68_RS18280	COG0126	phosphoglycerate kinase activity
HWV68_RS18285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWV68_RS18290	COG2390	Transcriptional regulator
HWV68_RS18295	COG2814	Major facilitator Superfamily
HWV68_RS18300	COG1609	Transcriptional regulator
HWV68_RS18305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS18310	COG0583	DNA-binding transcription factor activity
HWV68_RS18315	COG0697	spore germination
HWV68_RS18320	COG1113	amino acid transport
HWV68_RS18325	COG3858	chitin binding
HWV68_RS18330	COG1556	Lactate utilization protein
HWV68_RS18335	COG1139	Iron-sulfur cluster binding protein
HWV68_RS18340	COG0247	lactate metabolic process
HWV68_RS18345	COG2197	response regulator
HWV68_RS18350	COG4585	Histidine kinase
HWV68_RS18355	COG0842	Transport permease protein
HWV68_RS18360	COG1131	(ABC) transporter
HWV68_RS18365	COG0596	Alpha beta hydrolase
HWV68_RS18370	COG2208	phosphoserine phosphatase activity
HWV68_RS18375	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HWV68_RS18380	COG1874	Beta-galactosidase
HWV68_RS18385	COG3833	ABC-type maltose transport systems, permease component
HWV68_RS18390	COG1175	transmembrane transport
HWV68_RS18395	COG2182	Extracellular solute-binding protein
HWV68_RS18400	COG1609	Transcriptional regulator
HWV68_RS18405	COG2186	Transcriptional regulator
HWV68_RS18410	COG1620	l-lactate permease
HWV68_RS18415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HWV68_RS18425	COG5039	Polysaccharide pyruvyl transferase
HWV68_RS18430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_RS18435	COG0110	maltose O-acetyltransferase activity
HWV68_RS18440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWV68_RS18445	COG2244	polysaccharide biosynthetic process
HWV68_RS18450	COG1216	Glycosyl transferase, family 2
HWV68_RS18455	COG5039	Polysaccharide pyruvyl transferase
HWV68_RS18460	COG1216	Glycosyl transferase, family 2
HWV68_RS18470	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS18475	COG1215	transferase activity, transferring glycosyl groups
HWV68_RS18480	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS18485	COG1086	Polysaccharide biosynthesis protein
HWV68_RS18490	COG0489	protein tyrosine kinase activity
HWV68_RS18495	COG3944	biosynthesis protein
HWV68_RS18500	COG1396	sequence-specific DNA binding
HWV68_RS18505	COG2272	Belongs to the type-B carboxylesterase lipase family
HWV68_RS18515	COG3479	Phenolic acid decarboxylase
HWV68_RS18525	COG1794	racemase activity, acting on amino acids and derivatives
HWV68_RS18530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_RS18535	COG1621	beta-fructofuranosidase activity
HWV68_RS18540	COG1621	beta-fructofuranosidase activity
HWV68_RS18545	COG0531	amino acid
HWV68_RS18550	COG1309	transcriptional regulator
HWV68_RS18555	COG2076	Multidrug Resistance protein
HWV68_RS18560	COG2076	Multidrug Resistance protein
HWV68_RS18570	COG0277	FAD linked oxidase domain protein
HWV68_RS18575	COG3621	Patatin-like phospholipase
HWV68_RS18585	COG0740	serine-type endopeptidase activity
HWV68_RS18590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWV68_RS18595	COG0366	Alpha amylase catalytic
HWV68_RS18600	COG1554	hydrolase, family 65, central catalytic
HWV68_RS18605	COG5521	maltodextrose utilization protein MalA
HWV68_RS18610	COG3833	ABC-type maltose transport systems, permease component
HWV68_RS18615	COG1175	transmembrane transport
HWV68_RS18620	COG2182	Extracellular solute-binding protein
HWV68_RS18625	COG0366	Alpha amylase catalytic
HWV68_RS18630	COG1609	Transcriptional regulator
HWV68_RS18635	COG1611	Belongs to the LOG family
HWV68_RS18640	COG1694	Mazg nucleotide pyrophosphohydrolase
HWV68_RS18645	COG0659	secondary active sulfate transmembrane transporter activity
HWV68_RS18650	COG0288	reversible hydration of carbon dioxide
HWV68_RS18655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWV68_RS18660	COG0577	efflux transmembrane transporter activity
HWV68_RS18665	COG1136	(ABC) transporter
HWV68_RS18670	COG5002	protein histidine kinase activity
HWV68_RS18675	COG0745	RESPONSE REGULATOR receiver
HWV68_RS18685	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HWV68_RS18690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS18695	COG1481	regulation of sporulation
HWV68_RS18700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HWV68_RS18705	COG1660	Displays ATPase and GTPase activities
HWV68_RS18710	COG1051	belongs to the nudix hydrolase family
HWV68_RS18715	COG0492	ferredoxin-NADP+ reductase activity
HWV68_RS18720	COG0791	NLP P60 protein
HWV68_RS18720	COG3883	PFAM NLP P60 protein
HWV68_RS18725	COG0457	Tetratricopeptide repeat
HWV68_RS18730	COG1132	(ABC) transporter
HWV68_RS18750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWV68_RS18750	COG0140	phosphoribosyl-ATP diphosphatase activity
HWV68_RS18755	COG0107	imidazoleglycerol-phosphate synthase activity
HWV68_RS18760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HWV68_RS18765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWV68_RS18770	COG0131	Imidazoleglycerol-phosphate dehydratase
HWV68_RS18775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWV68_RS18780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWV68_RS18785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HWV68_RS18790	COG4990	cell redox homeostasis
HWV68_RS18795	COG5297	Belongs to the glycosyl hydrolase family 6
HWV68_RS18800	COG0110	maltose O-acetyltransferase activity
HWV68_RS18805	COG0546	phosphoglycolate phosphatase activity
HWV68_RS18810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HWV68_RS18815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HWV68_RS18820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HWV68_RS18825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HWV68_RS18830	COG0363	glucosamine-6-phosphate deaminase activity
HWV68_RS18835	COG2188	Transcriptional regulator
HWV68_RS18840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_RS18845	COG1846	Transcriptional regulator
HWV68_RS18850	COG2124	cytochrome p450
HWV68_RS18860	COG1846	Transcriptional regulator
HWV68_RS18865	COG2814	Major facilitator Superfamily
HWV68_RS18870	COG1950	PFAM Membrane protein of
HWV68_RS18875	COG1983	PspC domain protein
HWV68_RS18880	COG3595	metallopeptidase activity
HWV68_RS18900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWV68_RS18905	COG0556	nucleotide-excision repair
HWV68_RS18910	COG4897	Protein conserved in bacteria
HWV68_RS18915	COG3848	Pyruvate phosphate dikinase
HWV68_RS18915	COG0574	Belongs to the PEP-utilizing enzyme family
HWV68_RS18920	COG1309	transcriptional regulator
HWV68_RS18925	COG2814	Major facilitator Superfamily
HWV68_RS18930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_RS18940	COG0793	Belongs to the peptidase S41A family
HWV68_RS18940	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_RS18945	COG2177	Part of the ABC transporter FtsEX involved in
HWV68_RS18950	COG2884	Cell division ATP-binding protein ftsE
HWV68_RS18955	COG2010	Cytochrome c
HWV68_RS18960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS18970	COG0653	protein targeting
HWV68_RS18975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HWV68_RS18990	COG1516	flagellar protein fliS
HWV68_RS18995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HWV68_RS19000	COG1334	flagellar protein FlaG
HWV68_RS19005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWV68_RS19010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HWV68_RS19015	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HWV68_RS19025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWV68_RS19030	COG4786	Flagellar basal body rod
HWV68_RS19030	COG1256	bacterial-type flagellum assembly
HWV68_RS19035	COG3418	PFAM FlgN family protein
HWV68_RS19040	COG2747	anti-sigma28 factor FlgM
HWV68_RS19050	COG1040	competence protein
HWV68_RS19060	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HWV68_RS19065	COG1307	EDD domain protein, DegV family
HWV68_RS19070	COG2197	response regulator
HWV68_RS19075	COG4585	Histidine kinase
HWV68_RS19080	COG1739	Uncharacterized protein family UPF0029
HWV68_RS19085	COG1316	TRANSCRIPTIONal
HWV68_RS19090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWV68_RS19095	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS19100	COG1215	transferase activity, transferring glycosyl groups
HWV68_RS19105	COG3206	protein involved in exopolysaccharide biosynthesis
HWV68_RS19110	COG3307	-O-antigen
HWV68_RS19115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_RS19120	COG0297	glycogen (starch) synthase activity
HWV68_RS19120	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS19125	COG2244	polysaccharide biosynthetic process
HWV68_RS19135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_RS19135	COG2247	cell wall binding repeat
HWV68_RS19140	COG2247	cell wall binding repeat
HWV68_RS19140	COG2385	sporulation resulting in formation of a cellular spore
HWV68_RS19150	COG1316	TRANSCRIPTIONal
HWV68_RS19155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWV68_RS19160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_RS19170	COG1215	transferase activity, transferring glycosyl groups
HWV68_RS19170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_RS19175	COG0463	Glycosyl transferase, family 2
HWV68_RS19185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_RS19195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_RS19200	COG1134	teichoic acid transport
HWV68_RS19205	COG1682	transport, permease protein
HWV68_RS19210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_RS19215	COG0438	transferase activity, transferring glycosyl groups
HWV68_RS19220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HWV68_RS19225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HWV68_RS19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_RS19240	COG4193	domain, Protein
HWV68_RS19245	COG1482	cell wall glycoprotein biosynthetic process
HWV68_RS19250	COG0697	spore germination
HWV68_RS19255	COG0814	amino acid
HWV68_RS19265	COG2814	Major facilitator Superfamily
HWV68_RS19270	COG1316	TRANSCRIPTIONal
HWV68_RS19275	COG0561	phosphatase activity
HWV68_RS19280	COG0791	NLP P60 protein
HWV68_RS19290	COG2843	Capsule synthesis protein
HWV68_RS19300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWV68_RS19305	COG1609	Transcriptional regulator
HWV68_RS19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_RS19315	COG1869	D-ribose catabolic process
HWV68_RS19320	COG1129	ABC transporter
HWV68_RS19325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWV68_RS19330	COG1879	ABC-type sugar transport system periplasmic component
HWV68_RS19335	COG3103	Sh3 type 3 domain protein
HWV68_RS19345	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_RS19350	COG3527	Alpha-acetolactate decarboxylase
HWV68_RS19355	COG0028	Belongs to the TPP enzyme family
HWV68_RS19360	COG0583	DNA-binding transcription factor activity
HWV68_RS19365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWV68_RS19380	COG5337	Spore coat protein CotH
HWV68_RS19390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWV68_RS19400	COG0405	Gamma-glutamyltransferase
HWV68_RS19405	COG1522	sequence-specific DNA binding
HWV68_RS19410	COG2059	Chromate
HWV68_RS19415	COG2059	Chromate
HWV68_RS19425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWV68_RS19430	COG0583	DNA-binding transcription factor activity
HWV68_RS19435	COG1515	deoxyribonuclease V activity
HWV68_RS19440	COG2849	repeat protein
HWV68_RS19445	COG5444	nuclease activity
HWV68_RS19465	COG3878	Protein conserved in bacteria
HWV68_RS19470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_RS19475	COG4464	protein tyrosine phosphatase activity
HWV68_RS19480	COG0489	protein tyrosine kinase activity
HWV68_RS19485	COG3944	biosynthesis protein
HWV68_RS19495	COG4715	Zinc finger, swim domain protein
HWV68_RS19500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWV68_RS19505	COG0561	phosphatase activity
HWV68_RS19510	COG1349	DNA-binding transcription factor activity
HWV68_RS19515	COG0629	single-stranded DNA binding
HWV68_RS19540	COG0745	RESPONSE REGULATOR receiver
HWV68_RS19540	COG2972	Histidine kinase
HWV68_RS19545	COG1970	mechanosensitive ion channel activity
HWV68_RS19550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV68_RS19555	COG0457	Tetratricopeptide repeat
HWV68_RS19560	COG4786	Flagellar basal body rod
HWV68_RS19565	COG4786	Flagellar basal body rod
HWV68_RS19570	COG1077	Cell shape determining protein MreB Mrl
HWV68_RS19575	COG1609	Transcriptional regulator
HWV68_RS19585	COG1846	Transcriptional regulator
HWV68_RS19590	COG2814	Major facilitator Superfamily
HWV68_RS19595	COG3420	alginic acid biosynthetic process
HWV68_RS19600	COG1953	Uracil, thiamine, allantoin
HWV68_RS19605	COG0477	Major facilitator Superfamily
HWV68_RS19610	COG1335	isochorismatase
HWV68_RS19620	COG0004	ammonium transporteR
HWV68_RS19625	COG0347	Belongs to the P(II) protein family
HWV68_RS19630	COG0671	phosphoesterase, PA-phosphatase related
HWV68_RS19640	COG0739	heme binding
HWV68_RS19645	COG1247	-acetyltransferase
HWV68_RS19665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_RS19670	COG0789	Transcriptional regulator
HWV68_RS19680	COG2910	NAD(P)H-binding
HWV68_RS19685	COG1959	2 iron, 2 sulfur cluster binding
HWV68_RS19690	COG0804	urea catabolic process
HWV68_RS19695	COG0832	Belongs to the urease beta subunit family
HWV68_RS19700	COG0831	urea catabolic process
HWV68_RS19720	COG3237	CsbD-like
HWV68_RS19725	COG1994	Peptidase M50
HWV68_RS19730	COG0457	Tetratricopeptide repeat
HWV68_RS19735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWV68_RS19740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWV68_RS19750	COG2304	oxidoreductase activity
HWV68_RS19760	COG2304	oxidoreductase activity
HWV68_RS19765	COG2385	sporulation resulting in formation of a cellular spore
HWV68_RS19770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWV68_RS19780	COG4836	Membrane
HWV68_RS19790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWV68_RS19795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWV68_RS19800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HWV68_RS19805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWV68_RS19810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWV68_RS19815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWV68_RS19825	COG0356	it plays a direct role in the translocation of protons across the membrane
HWV68_RS19835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HWV68_RS19840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HWV68_RS19845	COG4475	Protein of unknown function (DUF436)
HWV68_RS19850	COG0698	ribose 5-phosphate isomerase
HWV68_RS19855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_RS19860	COG1971	Probably functions as a manganese efflux pump
HWV68_RS19865	COG0009	L-threonylcarbamoyladenylate synthase
HWV68_RS19870	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWV68_RS19890	COG2890	protein-(glutamine-N5) methyltransferase activity
HWV68_RS19895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWV68_RS19900	COG0346	lactoylglutathione lyase activity
HWV68_RS19905	COG0789	Transcriptional regulator
HWV68_RS19910	COG0679	Auxin Efflux Carrier
HWV68_RS19915	COG0281	malic enzyme
HWV68_RS19920	COG1435	thymidine kinase activity
HWV68_RS19930	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HWV68_RS19940	COG1494	fructose-1,6-bisphosphatase
HWV68_RS19945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWV68_RS19950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWV68_RS19955	COG0191	fructose-bisphosphate aldolase activity
HWV68_RS19960	COG2204	response regulator
HWV68_RS19965	COG4821	SIS domain
HWV68_RS19970	COG0504	CTP synthase activity
HWV68_RS19975	COG3343	RNA polymerase activity
HWV68_RS19980	COG1960	acyl-CoA dehydrogenase activity
HWV68_RS19985	COG2181	nitrate reductase activity
HWV68_RS19985	COG0247	lactate metabolic process
HWV68_RS19990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_RS19995	COG4294	response to UV
HWV68_RS20005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_RS20010	COG1132	(ABC) transporter
HWV68_RS20015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_RS20020	COG2181	nitrate reductase activity
HWV68_RS20025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HWV68_RS20030	COG1140	nitrate reductase beta subunit
HWV68_RS20035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HWV68_RS20040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWV68_RS20050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWV68_RS20055	COG2223	nitrite transmembrane transporter activity
HWV68_RS20060	COG0018	arginyl-trna synthetase
HWV68_RS20065	COG4506	Protein conserved in bacteria
HWV68_RS20080	COG0535	radical SAM domain protein
HWV68_RS20090	COG1131	(ABC) transporter
HWV68_RS20095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWV68_RS20100	COG0612	Peptidase, M16
HWV68_RS20105	COG0612	Peptidase, M16
HWV68_RS20115	COG3391	amine dehydrogenase activity
HWV68_RS20120	COG3391	amine dehydrogenase activity
HWV68_RS20125	COG0457	Tetratricopeptide repeat
HWV68_RS20135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWV68_RS20140	COG0010	Belongs to the arginase family
HWV68_RS20145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWV68_RS20150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_RS20160	COG1994	Peptidase M50
HWV68_RS20165	COG1942	4-Oxalocrotonate Tautomerase
HWV68_RS20170	COG1846	Transcriptional regulator
HWV68_RS20175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWV68_RS20180	COG0477	Major facilitator Superfamily
HWV68_RS20185	COG1959	2 iron, 2 sulfur cluster binding
HWV68_RS20190	COG3465	dGTPase activity
HWV68_RS20195	COG1078	dGTPase activity
HWV68_RS20200	COG4844	belongs to the
HWV68_RS20210	COG0697	spore germination
HWV68_RS20215	COG0095	Lipoate-protein ligase
HWV68_RS20220	COG0583	DNA-binding transcription factor activity
HWV68_RS20225	COG0280	phosphate acetyltransferase
HWV68_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS20240	COG0436	Aminotransferase
HWV68_RS20245	COG2814	Major facilitator Superfamily
HWV68_RS20250	COG0151	Belongs to the GarS family
HWV68_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS20260	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS20265	COG0077	Prephenate dehydratase
HWV68_RS20270	COG2814	Major facilitator Superfamily
HWV68_RS20275	COG0833	amino acid
HWV68_RS20280	COG4187	Peptidase family M20/M25/M40
HWV68_RS20285	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS20290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_RS20300	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HWV68_RS20305	COG1091	dTDP-4-dehydrorhamnose reductase activity
HWV68_RS20310	COG1088	dTDP-glucose 4,6-dehydratase activity
HWV68_RS20315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HWV68_RS20320	COG3980	spore coat polysaccharide biosynthesis protein
HWV68_RS20325	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HWV68_RS20330	COG2089	acid synthase
HWV68_RS20335	COG0456	acetyltransferase
HWV68_RS20340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_RS20345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_RS20350	COG0463	Glycosyl transferase, family 2
HWV68_RS20360	COG2363	Small membrane protein
HWV68_RS20365	COG2233	PERMEase
HWV68_RS20375	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS20380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HWV68_RS20385	COG1216	Glycosyl transferase, family 2
HWV68_RS20400	COG1695	Transcriptional regulator
HWV68_RS20405	COG0351	phosphomethylpyrimidine kinase
HWV68_RS20415	COG1621	beta-fructofuranosidase activity
HWV68_RS20420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS20420	COG1263	PTS System
HWV68_RS20425	COG2116	formate transmembrane transporter activity
HWV68_RS20430	COG3711	transcriptional antiterminator
HWV68_RS20440	COG1404	Belongs to the peptidase S8 family
HWV68_RS20445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS20450	COG0778	Nitroreductase
HWV68_RS20455	COG0772	Belongs to the SEDS family
HWV68_RS20465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWV68_RS20470	COG1845	cytochrome c oxidase, subunit III
HWV68_RS20475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWV68_RS20480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWV68_RS20485	COG2261	transglycosylase associated protein
HWV68_RS20490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HWV68_RS20495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HWV68_RS20500	COG2246	polysaccharide biosynthetic process
HWV68_RS20505	COG1309	transcriptional regulator
HWV68_RS20515	COG3162	membrane
HWV68_RS20520	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_RS20525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWV68_RS20530	COG2837	iron assimilation
HWV68_RS20535	COG2822	iron ion transport
HWV68_RS20540	COG0672	)-iron permease
HWV68_RS20545	COG0352	thiamine-phosphate diphosphorylase activity
HWV68_RS20550	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HWV68_RS20555	COG0583	DNA-binding transcription factor activity
HWV68_RS20560	COG1380	Effector of murein hydrolase LrgA
HWV68_RS20565	COG1346	cytolysis
HWV68_RS20570	COG2814	Major facilitator Superfamily
HWV68_RS20575	COG4895	conserved protein (DUF2196)
HWV68_RS20580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWV68_RS20585	COG0346	lactoylglutathione lyase activity
HWV68_RS20595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_RS20600	COG1404	Belongs to the peptidase S8 family
HWV68_RS20605	COG1263	PTS System
HWV68_RS20605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS20610	COG3711	transcriptional antiterminator
HWV68_RS20615	COG1442	glycosyl transferase family 8
HWV68_RS20620	COG5522	Integral membrane protein (intg_mem_TP0381)
HWV68_RS20625	COG1846	Transcriptional regulator
HWV68_RS20630	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWV68_RS20635	COG2234	aminopeptidase activity
HWV68_RS20640	COG2357	RelA SpoT domain protein
HWV68_RS20645	COG1575	Belongs to the MenA family. Type 1 subfamily
HWV68_RS20660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_RS20665	COG1696	Membrane protein involved in D-alanine export
HWV68_RS20670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_RS20675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HWV68_RS20680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HWV68_RS20685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_RS20690	COG1486	melibiose metabolic process
HWV68_RS20695	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWV68_RS20700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_RS20705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_RS20710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_RS20710	COG3711	transcriptional antiterminator
HWV68_RS20720	COG2094	Belongs to the DNA glycosylase MPG family
HWV68_RS20725	COG0753	catalase activity
HWV68_RS20730	COG2814	Major facilitator Superfamily
HWV68_RS20735	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_RS20740	COG1131	(ABC) transporter
HWV68_RS20760	COG1595	DNA-templated transcription, initiation
HWV68_RS20765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWV68_RS20770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWV68_RS20775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HWV68_RS20780	COG4988	ABC transporter
HWV68_RS20785	COG1294	oxidase, subunit
HWV68_RS20790	COG1271	oxidase subunit
HWV68_RS20795	COG3493	citrate carrier protein
HWV68_RS20800	COG0501	Belongs to the peptidase M48B family
HWV68_RS20810	COG0726	polysaccharide deacetylase
HWV68_RS20815	COG3842	ATPase activity
HWV68_RS20820	COG2508	Transcriptional regulator
HWV68_RS20825	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS20830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_RS20840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWV68_RS20845	COG1881	PFAM PEBP family protein
HWV68_RS20850	COG0583	DNA-binding transcription factor activity
HWV68_RS20860	COG4585	Histidine kinase
HWV68_RS20865	COG2197	response regulator
HWV68_RS20870	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWV68_RS20880	COG4894	glucomannan catabolic process
HWV68_RS20885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_RS20890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS20900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWV68_RS20905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWV68_RS20910	COG2610	gluconate transmembrane transporter activity
HWV68_RS20915	COG0500	methyltransferase
HWV68_RS20920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_RS20935	COG0753	catalase activity
HWV68_RS20935	COG0693	protein deglycase activity
HWV68_RS20940	COG2851	Citrate transporter
HWV68_RS20945	COG2273	Hydrolase Family 16
HWV68_RS20950	COG3711	transcriptional antiterminator
HWV68_RS20960	COG2270	Major facilitator Superfamily
HWV68_RS20965	COG0513	Belongs to the DEAD box helicase family
HWV68_RS20970	COG3401	FG-GAP repeat protein
HWV68_RS20970	COG2755	lipolytic protein G-D-S-L family
HWV68_RS21025	COG3209	COG3209 Rhs family protein
HWV68_RS21030	COG0697	spore germination
HWV68_RS21035	COG0589	response to stress
HWV68_RS21040	COG2723	6-phospho-beta-galactosidase activity
HWV68_RS21045	COG1263	PTS System
HWV68_RS21045	COG2190	(PTS) system
HWV68_RS21045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_RS21060	COG5444	nuclease activity
HWV68_RS21075	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_RS21090	COG2986	histidine ammonia-lyase
HWV68_RS21095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HWV68_RS21100	COG1228	amidohydrolase
HWV68_RS21105	COG0010	Belongs to the arginase family
HWV68_RS21110	COG0833	amino acid
HWV68_RS21115	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HWV68_RS21120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_RS21125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HWV68_RS21130	COG2390	Transcriptional regulator
HWV68_RS21140	COG3192	ethanolamine utilization protein
HWV68_RS21145	COG2079	MmgE PrpD family protein
HWV68_RS21150	COG1473	amidohydrolase
HWV68_RS21155	COG1126	abc transporter atp-binding protein
HWV68_RS21160	COG0765	amino acid transport
HWV68_RS21165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_RS21170	COG0456	acetyltransferase
HWV68_RS21175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_RS21185	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HWV68_RS21190	COG0561	phosphatase activity
HWV68_RS21220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_RS21225	COG5294	Protein conserved in bacteria
HWV68_RS21230	COG0577	efflux transmembrane transporter activity
HWV68_RS21235	COG1136	(ABC) transporter
HWV68_RS21240	COG2205	protein histidine kinase activity
HWV68_RS21245	COG0745	RESPONSE REGULATOR receiver
HWV68_RS21250	COG0191	fructose-bisphosphate aldolase activity
HWV68_RS21255	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_RS21260	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_RS21265	COG0673	inositol 2-dehydrogenase activity
HWV68_RS21270	COG2814	Major facilitator Superfamily
HWV68_RS21275	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_RS21280	COG3962	Belongs to the TPP enzyme family
HWV68_RS21285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_RS21290	COG3718	enzyme involved in inositol metabolism
HWV68_RS21295	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS21300	COG1349	DNA-binding transcription factor activity
HWV68_RS21305	COG0667	Aldo Keto reductase
HWV68_RS21320	COG2814	Major facilitator Superfamily
HWV68_RS21325	COG0326	Molecular chaperone. Has ATPase activity
HWV68_RS21335	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS21340	COG1309	transcriptional regulator
HWV68_RS21345	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_RS21350	COG0456	acetyltransferase
HWV68_RS21355	COG2850	peptidyl-arginine hydroxylation
HWV68_RS21360	COG2226	methyltransferase
HWV68_RS21375	COG0367	asparagine synthase
HWV68_RS21380	COG2814	Major facilitator Superfamily
HWV68_RS21385	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV68_RS21395	COG1714	RDD family
HWV68_RS21400	COG2311	Membrane
HWV68_RS21405	COG1917	Cupin 2, conserved barrel domain protein
HWV68_RS21410	COG1309	transcriptional regulator
HWV68_RS21415	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_RS21420	COG1846	Transcriptional regulator
HWV68_RS21425	COG1380	Effector of murein hydrolase LrgA
HWV68_RS21430	COG1346	cytolysis
HWV68_RS21435	COG5039	Polysaccharide pyruvyl transferase
HWV68_RS21440	COG1929	Belongs to the glycerate kinase type-1 family
HWV68_RS21445	COG1802	Transcriptional regulator
HWV68_RS21450	COG1070	Carbohydrate kinase
HWV68_RS21455	COG2610	gluconate transmembrane transporter activity
HWV68_RS21460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWV68_RS21465	COG0450	alkyl hydroperoxide reductase
HWV68_RS21470	COG3634	alkyl hydroperoxide reductase activity
HWV68_RS21475	COG2723	6-phospho-beta-galactosidase activity
HWV68_RS21485	COG2188	Transcriptional regulator
HWV68_RS21500	COG1131	(ABC) transporter
HWV68_RS21505	COG1994	Peptidase M50
HWV68_RS21510	COG0535	radical SAM domain protein
HWV68_RS21520	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HWV68_RS21525	COG5293	efflux transmembrane transporter activity
HWV68_RS21535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_RS21540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HWV68_RS21555	COG1063	alcohol dehydrogenase
HWV68_RS21575	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HWV68_RS21580	COG0456	acetyltransferase
HWV68_RS21585	COG0457	Tetratricopeptide repeat
HWV68_RS21595	COG0010	Belongs to the arginase family
HWV68_RS21600	COG0833	amino acid
HWV68_RS21605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWV68_RS21610	COG3829	transcription factor binding
HWV68_RS21625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_RS21630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HWV68_RS21635	COG4853	Protein conserved in bacteria
HWV68_RS21640	COG4863	YycH protein
HWV68_RS21645	COG5002	protein histidine kinase activity
HWV68_RS21650	COG0745	RESPONSE REGULATOR receiver
HWV68_RS21680	COG0346	lactoylglutathione lyase activity
HWV68_RS21685	COG0305	Participates in initiation and elongation during chromosome replication
HWV68_RS21700	COG3093	addiction module antidote protein HigA
HWV68_RS21705	COG2807	transmembrane transport
HWV68_RS21710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWV68_RS21715	COG0359	binds to the 23S rRNA
HWV68_RS21720	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HWV68_RS21725	COG4241	membrane
HWV68_RS21735	COG5577	PFAM Coat F domain
HWV68_RS21740	COG1733	regulation of RNA biosynthetic process
HWV68_RS21745	COG1227	inorganic diphosphatase activity
HWV68_RS21760	COG2271	Major facilitator Superfamily
HWV68_RS21795	COG1131	(ABC) transporter
HWV68_RS21810	COG4319	ketosteroid isomerase
HWV68_RS21815	COG1357	PFAM Pentapeptide repeats (8 copies)
HWV68_RS21820	COG2814	Major facilitator Superfamily
HWV68_RS21825	COG0583	DNA-binding transcription factor activity
HWV68_RS21830	COG2153	protein acetylation
HWV68_RS21840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_RS21845	COG1846	Transcriptional regulator
HWV68_RS21850	COG2153	protein acetylation
HWV68_RS21855	COG2364	Membrane
HWV68_RS21860	COG0456	acetyltransferase
HWV68_RS21865	COG2315	Protein conserved in bacteria
HWV68_RS21870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_RS21880	COG2814	Major facilitator Superfamily
HWV68_RS21890	COG1331	Highly conserved protein containing a thioredoxin domain
HWV68_RS21895	COG0789	Transcriptional regulator
HWV68_RS21900	COG0697	spore germination
HWV68_RS21905	COG1331	Highly conserved protein containing a thioredoxin domain
HWV68_RS21910	COG1266	CAAX protease self-immunity
HWV68_RS21915	COG0477	Major facilitator Superfamily
HWV68_RS21915	COG2814	Major facilitator Superfamily
HWV68_RS21920	COG0110	maltose O-acetyltransferase activity
HWV68_RS21925	COG0346	lactoylglutathione lyase activity
HWV68_RS21930	COG1609	Transcriptional regulator
HWV68_RS21935	COG0708	Exodeoxyribonuclease III
HWV68_RS21940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWV68_RS21945	COG0629	single-stranded DNA binding
HWV68_RS21950	COG0360	Binds together with S18 to 16S ribosomal RNA
HWV68_RS21955	COG0012	GTP binding
HWV68_RS21960	COG0243	molybdopterin cofactor binding
HWV68_RS21965	COG4481	Protein conserved in bacteria
HWV68_RS21970	COG3949	Membrane
HWV68_RS21980	COG1475	DNA binding
HWV68_RS21985	COG1192	Involved in chromosome partitioning
HWV68_RS21995	COG1475	DNA binding
HWV68_RS22000	COG0357	Ribosomal RNA small subunit methyltransferase G
HWV68_RS22005	COG0445	tRNA wobble uridine modification
HWV68_RS22010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HWV68_RS22015	COG1847	R3H domain protein
HWV68_RS22020	COG0706	membrane insertase activity
HWV68_RS22025	COG0594	ribonuclease P activity