locus-tag	class	description
DXY22_RS00015	COG0140	phosphoribosyl-ATP diphosphatase activity
DXY22_RS00015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DXY22_RS00020	COG0107	imidazoleglycerol-phosphate synthase activity
DXY22_RS00025	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DXY22_RS00030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DXY22_RS00035	COG0131	Imidazoleglycerol-phosphate dehydratase
DXY22_RS00040	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DXY22_RS00045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DXY22_RS00050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DXY22_RS00055	COG4990	cell redox homeostasis
DXY22_RS00060	COG5297	Belongs to the glycosyl hydrolase family 6
DXY22_RS00065	COG0110	maltose O-acetyltransferase activity
DXY22_RS00070	COG0546	phosphoglycolate phosphatase activity
DXY22_RS00075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DXY22_RS00080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DXY22_RS00085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DXY22_RS00090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DXY22_RS00095	COG0363	glucosamine-6-phosphate deaminase activity
DXY22_RS00105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DXY22_RS00110	COG1846	Transcriptional regulator
DXY22_RS00115	COG2124	cytochrome p450
DXY22_RS00125	COG1846	Transcriptional regulator
DXY22_RS00130	COG2814	Major facilitator Superfamily
DXY22_RS00135	COG1950	PFAM Membrane protein of
DXY22_RS00140	COG1983	PspC domain protein
DXY22_RS00145	COG3595	metallopeptidase activity
DXY22_RS00165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DXY22_RS00170	COG0556	nucleotide-excision repair
DXY22_RS00175	COG4897	Protein conserved in bacteria
DXY22_RS00180	COG0574	Belongs to the PEP-utilizing enzyme family
DXY22_RS00180	COG3848	Pyruvate phosphate dikinase
DXY22_RS00185	COG1309	transcriptional regulator
DXY22_RS00190	COG2814	Major facilitator Superfamily
DXY22_RS00195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_RS00205	COG0793	Belongs to the peptidase S41A family
DXY22_RS00205	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS00210	COG2177	Part of the ABC transporter FtsEX involved in
DXY22_RS00215	COG2884	Cell division ATP-binding protein ftsE
DXY22_RS00220	COG2010	Cytochrome c
DXY22_RS00225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS00235	COG0653	protein targeting
DXY22_RS00240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DXY22_RS00255	COG1516	flagellar protein fliS
DXY22_RS00260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DXY22_RS00265	COG1334	flagellar protein FlaG
DXY22_RS00270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY22_RS00275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DXY22_RS00280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DXY22_RS00290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY22_RS00295	COG4786	Flagellar basal body rod
DXY22_RS00295	COG1256	bacterial-type flagellum assembly
DXY22_RS00300	COG3418	PFAM FlgN family protein
DXY22_RS00305	COG2747	anti-sigma28 factor FlgM
DXY22_RS00315	COG1040	competence protein
DXY22_RS00325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DXY22_RS00330	COG1307	EDD domain protein, DegV family
DXY22_RS00335	COG2197	response regulator
DXY22_RS00340	COG4585	Histidine kinase
DXY22_RS00345	COG1739	Uncharacterized protein family UPF0029
DXY22_RS00350	COG1316	TRANSCRIPTIONal
DXY22_RS00355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DXY22_RS00360	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS00365	COG1215	transferase activity, transferring glycosyl groups
DXY22_RS00370	COG3206	protein involved in exopolysaccharide biosynthesis
DXY22_RS00375	COG3307	-O-antigen
DXY22_RS00380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_RS00385	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS00385	COG0297	glycogen (starch) synthase activity
DXY22_RS00390	COG2244	polysaccharide biosynthetic process
DXY22_RS00405	COG2247	cell wall binding repeat
DXY22_RS00405	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS00410	COG2247	cell wall binding repeat
DXY22_RS00410	COG2385	sporulation resulting in formation of a cellular spore
DXY22_RS00420	COG1316	TRANSCRIPTIONal
DXY22_RS00425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DXY22_RS00445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_RS00450	COG1134	teichoic acid transport
DXY22_RS00455	COG1682	transport, permease protein
DXY22_RS00460	COG1215	transferase activity, transferring glycosyl groups
DXY22_RS00460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY22_RS00465	COG0463	Glycosyl transferase, family 2
DXY22_RS00510	COG4193	domain, Protein
DXY22_RS00515	COG1482	cell wall glycoprotein biosynthetic process
DXY22_RS00520	COG0697	spore germination
DXY22_RS00525	COG0814	amino acid
DXY22_RS00535	COG2814	Major facilitator Superfamily
DXY22_RS00540	COG1316	TRANSCRIPTIONal
DXY22_RS00545	COG0561	phosphatase activity
DXY22_RS00550	COG0791	NLP P60 protein
DXY22_RS00560	COG2843	Capsule synthesis protein
DXY22_RS00570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DXY22_RS00575	COG1609	Transcriptional regulator
DXY22_RS00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_RS00585	COG1869	D-ribose catabolic process
DXY22_RS00590	COG1129	ABC transporter
DXY22_RS00595	COG1172	Belongs to the binding-protein-dependent transport system permease family
DXY22_RS00600	COG1879	ABC-type sugar transport system periplasmic component
DXY22_RS00605	COG3103	Sh3 type 3 domain protein
DXY22_RS00615	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_RS00620	COG3527	Alpha-acetolactate decarboxylase
DXY22_RS00625	COG0028	Belongs to the TPP enzyme family
DXY22_RS00630	COG0583	DNA-binding transcription factor activity
DXY22_RS00635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY22_RS00650	COG5337	Spore coat protein CotH
DXY22_RS00660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DXY22_RS00670	COG0405	Gamma-glutamyltransferase
DXY22_RS00675	COG1522	sequence-specific DNA binding
DXY22_RS00680	COG2059	Chromate
DXY22_RS00685	COG2059	Chromate
DXY22_RS00695	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY22_RS00700	COG0583	DNA-binding transcription factor activity
DXY22_RS00715	COG5444	nuclease activity
DXY22_RS00735	COG3878	Protein conserved in bacteria
DXY22_RS00740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_RS00745	COG4464	protein tyrosine phosphatase activity
DXY22_RS00750	COG0489	protein tyrosine kinase activity
DXY22_RS00755	COG3944	biosynthesis protein
DXY22_RS00765	COG4715	Zinc finger, swim domain protein
DXY22_RS00770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY22_RS00775	COG0561	phosphatase activity
DXY22_RS00780	COG1349	DNA-binding transcription factor activity
DXY22_RS00785	COG0629	single-stranded DNA binding
DXY22_RS00800	COG3764	Sortase (surface protein transpeptidase)
DXY22_RS00810	COG3279	Response regulator of the LytR AlgR family
DXY22_RS00825	COG1970	mechanosensitive ion channel activity
DXY22_RS00830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DXY22_RS00835	COG0457	Tetratricopeptide repeat
DXY22_RS00840	COG4786	Flagellar basal body rod
DXY22_RS00845	COG4786	Flagellar basal body rod
DXY22_RS00850	COG1077	Cell shape determining protein MreB Mrl
DXY22_RS00855	COG1609	Transcriptional regulator
DXY22_RS00865	COG1846	Transcriptional regulator
DXY22_RS00870	COG2814	Major facilitator Superfamily
DXY22_RS00875	COG3420	alginic acid biosynthetic process
DXY22_RS00880	COG1953	Uracil, thiamine, allantoin
DXY22_RS00885	COG0477	Major facilitator Superfamily
DXY22_RS00890	COG1335	isochorismatase
DXY22_RS00900	COG0004	ammonium transporteR
DXY22_RS00905	COG0347	Belongs to the P(II) protein family
DXY22_RS00910	COG0671	phosphoesterase, PA-phosphatase related
DXY22_RS00935	COG0739	heme binding
DXY22_RS00940	COG1247	-acetyltransferase
DXY22_RS00960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_RS00965	COG0789	Transcriptional regulator
DXY22_RS00975	COG2910	NAD(P)H-binding
DXY22_RS00980	COG1959	2 iron, 2 sulfur cluster binding
DXY22_RS00985	COG0804	urea catabolic process
DXY22_RS00990	COG0832	Belongs to the urease beta subunit family
DXY22_RS00995	COG0831	urea catabolic process
DXY22_RS01010	COG3237	CsbD-like
DXY22_RS01015	COG1994	Peptidase M50
DXY22_RS01020	COG0457	Tetratricopeptide repeat
DXY22_RS01025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DXY22_RS01030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DXY22_RS01040	COG2304	oxidoreductase activity
DXY22_RS01050	COG2304	oxidoreductase activity
DXY22_RS01055	COG2385	sporulation resulting in formation of a cellular spore
DXY22_RS01060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY22_RS01070	COG4836	Membrane
DXY22_RS01080	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DXY22_RS01085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DXY22_RS01090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DXY22_RS01095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DXY22_RS01100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DXY22_RS01105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DXY22_RS01110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DXY22_RS01115	COG0356	it plays a direct role in the translocation of protons across the membrane
DXY22_RS01125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DXY22_RS01130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DXY22_RS01135	COG4475	Protein of unknown function (DUF436)
DXY22_RS01140	COG0698	ribose 5-phosphate isomerase
DXY22_RS01145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY22_RS01150	COG1971	Probably functions as a manganese efflux pump
DXY22_RS01155	COG0009	L-threonylcarbamoyladenylate synthase
DXY22_RS01160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DXY22_RS01180	COG2890	protein-(glutamine-N5) methyltransferase activity
DXY22_RS01185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DXY22_RS01190	COG0346	lactoylglutathione lyase activity
DXY22_RS01195	COG0789	Transcriptional regulator
DXY22_RS01200	COG0679	Auxin Efflux Carrier
DXY22_RS01205	COG0281	malic enzyme
DXY22_RS01210	COG1435	thymidine kinase activity
DXY22_RS01215	COG0254	rRNA binding
DXY22_RS01220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DXY22_RS01230	COG1494	fructose-1,6-bisphosphatase
DXY22_RS01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY22_RS01240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DXY22_RS01245	COG0191	fructose-bisphosphate aldolase activity
DXY22_RS01250	COG2204	response regulator
DXY22_RS01255	COG4821	SIS domain
DXY22_RS01260	COG0504	CTP synthase activity
DXY22_RS01265	COG3343	RNA polymerase activity
DXY22_RS01270	COG1960	acyl-CoA dehydrogenase activity
DXY22_RS01275	COG0247	lactate metabolic process
DXY22_RS01275	COG2181	nitrate reductase activity
DXY22_RS01280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_RS01285	COG4294	response to UV
DXY22_RS01295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_RS01300	COG1132	(ABC) transporter
DXY22_RS01305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_RS01315	COG2181	nitrate reductase activity
DXY22_RS01320	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DXY22_RS01325	COG1140	nitrate reductase beta subunit
DXY22_RS01330	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DXY22_RS01335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY22_RS01345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY22_RS01350	COG2223	nitrite transmembrane transporter activity
DXY22_RS01355	COG0018	arginyl-trna synthetase
DXY22_RS01360	COG4506	Protein conserved in bacteria
DXY22_RS01375	COG0535	radical SAM domain protein
DXY22_RS01385	COG1131	(ABC) transporter
DXY22_RS01390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DXY22_RS01395	COG0612	Peptidase, M16
DXY22_RS01400	COG0612	Peptidase, M16
DXY22_RS01410	COG3391	amine dehydrogenase activity
DXY22_RS01415	COG3391	amine dehydrogenase activity
DXY22_RS01420	COG0457	Tetratricopeptide repeat
DXY22_RS01435	COG0010	Belongs to the arginase family
DXY22_RS01440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DXY22_RS01445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_RS01455	COG1994	Peptidase M50
DXY22_RS01460	COG1942	4-Oxalocrotonate Tautomerase
DXY22_RS01465	COG1846	Transcriptional regulator
DXY22_RS01470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DXY22_RS01475	COG0477	Major facilitator Superfamily
DXY22_RS01480	COG1959	2 iron, 2 sulfur cluster binding
DXY22_RS01485	COG3465	dGTPase activity
DXY22_RS01490	COG1078	dGTPase activity
DXY22_RS01495	COG4844	belongs to the
DXY22_RS01505	COG0697	spore germination
DXY22_RS01510	COG0095	Lipoate-protein ligase
DXY22_RS01515	COG0583	DNA-binding transcription factor activity
DXY22_RS01520	COG0280	phosphate acetyltransferase
DXY22_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS01535	COG0436	Aminotransferase
DXY22_RS01540	COG2814	Major facilitator Superfamily
DXY22_RS01545	COG0151	Belongs to the GarS family
DXY22_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS01555	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS01560	COG0077	Prephenate dehydratase
DXY22_RS01565	COG2814	Major facilitator Superfamily
DXY22_RS01570	COG0833	amino acid
DXY22_RS01575	COG4187	Peptidase family M20/M25/M40
DXY22_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS01585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_RS01595	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DXY22_RS01600	COG1091	dTDP-4-dehydrorhamnose reductase activity
DXY22_RS01605	COG1088	dTDP-glucose 4,6-dehydratase activity
DXY22_RS01610	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DXY22_RS01615	COG3980	spore coat polysaccharide biosynthesis protein
DXY22_RS01620	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DXY22_RS01625	COG2089	acid synthase
DXY22_RS01630	COG0456	acetyltransferase
DXY22_RS01635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_RS01640	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY22_RS01645	COG0463	Glycosyl transferase, family 2
DXY22_RS01655	COG2363	Small membrane protein
DXY22_RS01660	COG2233	PERMEase
DXY22_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS01675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DXY22_RS01680	COG1216	Glycosyl transferase, family 2
DXY22_RS01695	COG1695	Transcriptional regulator
DXY22_RS01700	COG0351	phosphomethylpyrimidine kinase
DXY22_RS01710	COG1621	beta-fructofuranosidase activity
DXY22_RS01715	COG1263	PTS System
DXY22_RS01715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS01720	COG2116	formate transmembrane transporter activity
DXY22_RS01725	COG3711	transcriptional antiterminator
DXY22_RS01735	COG1404	Belongs to the peptidase S8 family
DXY22_RS01740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS01745	COG0778	Nitroreductase
DXY22_RS01750	COG0772	Belongs to the SEDS family
DXY22_RS01760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DXY22_RS01765	COG1845	cytochrome c oxidase, subunit III
DXY22_RS01770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY22_RS01775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY22_RS01780	COG2261	transglycosylase associated protein
DXY22_RS01785	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DXY22_RS01790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DXY22_RS01795	COG2246	polysaccharide biosynthetic process
DXY22_RS01800	COG1309	transcriptional regulator
DXY22_RS01810	COG3162	membrane
DXY22_RS01815	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_RS01820	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DXY22_RS01825	COG2837	iron assimilation
DXY22_RS01830	COG2822	iron ion transport
DXY22_RS01835	COG0672	)-iron permease
DXY22_RS01840	COG0352	thiamine-phosphate diphosphorylase activity
DXY22_RS01845	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DXY22_RS01850	COG0583	DNA-binding transcription factor activity
DXY22_RS01855	COG1380	Effector of murein hydrolase LrgA
DXY22_RS01860	COG1346	cytolysis
DXY22_RS01865	COG2814	Major facilitator Superfamily
DXY22_RS01870	COG4895	conserved protein (DUF2196)
DXY22_RS01875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DXY22_RS01880	COG0346	lactoylglutathione lyase activity
DXY22_RS01890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_RS01895	COG1404	Belongs to the peptidase S8 family
DXY22_RS01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS01900	COG1263	PTS System
DXY22_RS01905	COG3711	transcriptional antiterminator
DXY22_RS01910	COG1442	glycosyl transferase family 8
DXY22_RS01915	COG5522	Integral membrane protein (intg_mem_TP0381)
DXY22_RS01920	COG1846	Transcriptional regulator
DXY22_RS01925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DXY22_RS01930	COG2234	aminopeptidase activity
DXY22_RS01945	COG2814	Major facilitator Superfamily
DXY22_RS01950	COG2357	RelA SpoT domain protein
DXY22_RS01955	COG1575	Belongs to the MenA family. Type 1 subfamily
DXY22_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS01975	COG1696	Membrane protein involved in D-alanine export
DXY22_RS01980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS01985	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DXY22_RS01990	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DXY22_RS01995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_RS02000	COG1486	melibiose metabolic process
DXY22_RS02005	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY22_RS02010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_RS02015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_RS02020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS02020	COG3711	transcriptional antiterminator
DXY22_RS02030	COG2094	Belongs to the DNA glycosylase MPG family
DXY22_RS02035	COG0753	catalase activity
DXY22_RS02045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_RS02050	COG1131	(ABC) transporter
DXY22_RS02070	COG1595	DNA-templated transcription, initiation
DXY22_RS02075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY22_RS02080	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DXY22_RS02085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DXY22_RS02090	COG4988	ABC transporter
DXY22_RS02095	COG1294	oxidase, subunit
DXY22_RS02100	COG1271	oxidase subunit
DXY22_RS02105	COG3493	citrate carrier protein
DXY22_RS02110	COG0501	Belongs to the peptidase M48B family
DXY22_RS02120	COG0726	polysaccharide deacetylase
DXY22_RS02125	COG3842	ATPase activity
DXY22_RS02130	COG2508	Transcriptional regulator
DXY22_RS02135	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS02140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS02150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DXY22_RS02160	COG4585	Histidine kinase
DXY22_RS02165	COG2197	response regulator
DXY22_RS02170	COG2195	Cleaves the N-terminal amino acid of tripeptides
DXY22_RS02180	COG4894	glucomannan catabolic process
DXY22_RS02185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_RS02190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_RS02195	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS02200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY22_RS02205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY22_RS02210	COG2610	gluconate transmembrane transporter activity
DXY22_RS02215	COG0500	methyltransferase
DXY22_RS02220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_RS02235	COG0693	protein deglycase activity
DXY22_RS02235	COG0753	catalase activity
DXY22_RS02240	COG2851	Citrate transporter
DXY22_RS02245	COG2273	Hydrolase Family 16
DXY22_RS02250	COG3711	transcriptional antiterminator
DXY22_RS02260	COG2270	Major facilitator Superfamily
DXY22_RS02265	COG0513	Belongs to the DEAD box helicase family
DXY22_RS02270	COG2755	lipolytic protein G-D-S-L family
DXY22_RS02270	COG3401	FG-GAP repeat protein
DXY22_RS02340	COG0697	spore germination
DXY22_RS02345	COG0589	response to stress
DXY22_RS02350	COG2723	6-phospho-beta-galactosidase activity
DXY22_RS02355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS02355	COG2190	(PTS) system
DXY22_RS02355	COG1263	PTS System
DXY22_RS02365	COG5444	nuclease activity
DXY22_RS02380	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_RS02390	COG2986	histidine ammonia-lyase
DXY22_RS02395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DXY22_RS02400	COG1228	amidohydrolase
DXY22_RS02405	COG0010	Belongs to the arginase family
DXY22_RS02410	COG0833	amino acid
DXY22_RS02415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DXY22_RS02420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_RS02425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DXY22_RS02430	COG2390	Transcriptional regulator
DXY22_RS02440	COG3192	ethanolamine utilization protein
DXY22_RS02445	COG2079	MmgE PrpD family protein
DXY22_RS02455	COG1126	abc transporter atp-binding protein
DXY22_RS02460	COG0765	amino acid transport
DXY22_RS02465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS02485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DXY22_RS02490	COG0561	phosphatase activity
DXY22_RS02520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS02525	COG5294	Protein conserved in bacteria
DXY22_RS02530	COG0577	efflux transmembrane transporter activity
DXY22_RS02535	COG1136	(ABC) transporter
DXY22_RS02540	COG2205	protein histidine kinase activity
DXY22_RS02545	COG0745	RESPONSE REGULATOR receiver
DXY22_RS02550	COG0191	fructose-bisphosphate aldolase activity
DXY22_RS02555	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_RS02560	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_RS02565	COG0673	inositol 2-dehydrogenase activity
DXY22_RS02570	COG2814	Major facilitator Superfamily
DXY22_RS02575	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_RS02580	COG3962	Belongs to the TPP enzyme family
DXY22_RS02585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_RS02595	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS02600	COG1349	DNA-binding transcription factor activity
DXY22_RS02605	COG0667	Aldo Keto reductase
DXY22_RS02620	COG2814	Major facilitator Superfamily
DXY22_RS02625	COG0326	Molecular chaperone. Has ATPase activity
DXY22_RS02635	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS02640	COG1309	transcriptional regulator
DXY22_RS02645	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS02650	COG0456	acetyltransferase
DXY22_RS02655	COG2850	peptidyl-arginine hydroxylation
DXY22_RS02660	COG2226	methyltransferase
DXY22_RS02675	COG0367	asparagine synthase
DXY22_RS02680	COG2814	Major facilitator Superfamily
DXY22_RS02685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DXY22_RS02695	COG1714	RDD family
DXY22_RS02700	COG2311	Membrane
DXY22_RS02705	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS02710	COG1309	transcriptional regulator
DXY22_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS02720	COG1846	Transcriptional regulator
DXY22_RS02725	COG1380	Effector of murein hydrolase LrgA
DXY22_RS02730	COG1346	cytolysis
DXY22_RS02735	COG5039	Polysaccharide pyruvyl transferase
DXY22_RS02740	COG1929	Belongs to the glycerate kinase type-1 family
DXY22_RS02745	COG1802	Transcriptional regulator
DXY22_RS02750	COG1070	Carbohydrate kinase
DXY22_RS02755	COG2610	gluconate transmembrane transporter activity
DXY22_RS02760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DXY22_RS02765	COG0450	alkyl hydroperoxide reductase
DXY22_RS02770	COG3634	alkyl hydroperoxide reductase activity
DXY22_RS02780	COG2723	6-phospho-beta-galactosidase activity
DXY22_RS02795	COG2188	Transcriptional regulator
DXY22_RS02805	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DXY22_RS02840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DXY22_RS02855	COG1063	alcohol dehydrogenase
DXY22_RS02875	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DXY22_RS02880	COG0456	acetyltransferase
DXY22_RS02885	COG0457	Tetratricopeptide repeat
DXY22_RS02895	COG0010	Belongs to the arginase family
DXY22_RS02900	COG0833	amino acid
DXY22_RS02905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY22_RS02910	COG3829	transcription factor binding
DXY22_RS02915	COG5002	protein histidine kinase activity
DXY22_RS02940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_RS02945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DXY22_RS02950	COG4853	Protein conserved in bacteria
DXY22_RS02955	COG4863	YycH protein
DXY22_RS02960	COG5002	protein histidine kinase activity
DXY22_RS02965	COG0745	RESPONSE REGULATOR receiver
DXY22_RS02995	COG0346	lactoylglutathione lyase activity
DXY22_RS03000	COG0305	Participates in initiation and elongation during chromosome replication
DXY22_RS03015	COG3093	addiction module antidote protein HigA
DXY22_RS03020	COG2807	transmembrane transport
DXY22_RS03025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DXY22_RS03030	COG0359	binds to the 23S rRNA
DXY22_RS03035	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DXY22_RS03040	COG4241	membrane
DXY22_RS03050	COG5577	PFAM Coat F domain
DXY22_RS03055	COG1733	regulation of RNA biosynthetic process
DXY22_RS03060	COG1227	inorganic diphosphatase activity
DXY22_RS03070	COG2271	Major facilitator Superfamily
DXY22_RS03075	COG0789	Transcriptional regulator
DXY22_RS03075	COG4978	Transcriptional regulator
DXY22_RS03085	COG4319	ketosteroid isomerase
DXY22_RS03090	COG1357	PFAM Pentapeptide repeats (8 copies)
DXY22_RS03095	COG2814	Major facilitator Superfamily
DXY22_RS03100	COG0583	DNA-binding transcription factor activity
DXY22_RS03105	COG2153	protein acetylation
DXY22_RS03115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS03120	COG1846	Transcriptional regulator
DXY22_RS03125	COG2153	protein acetylation
DXY22_RS03130	COG2364	Membrane
DXY22_RS03135	COG0456	acetyltransferase
DXY22_RS03140	COG2315	Protein conserved in bacteria
DXY22_RS03145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_RS03155	COG2814	Major facilitator Superfamily
DXY22_RS03165	COG1331	Highly conserved protein containing a thioredoxin domain
DXY22_RS03180	COG0789	Transcriptional regulator
DXY22_RS03185	COG0697	spore germination
DXY22_RS03190	COG1331	Highly conserved protein containing a thioredoxin domain
DXY22_RS03195	COG1266	CAAX protease self-immunity
DXY22_RS03200	COG2814	Major facilitator Superfamily
DXY22_RS03200	COG0477	Major facilitator Superfamily
DXY22_RS03205	COG0110	maltose O-acetyltransferase activity
DXY22_RS03210	COG0346	lactoylglutathione lyase activity
DXY22_RS03215	COG1609	Transcriptional regulator
DXY22_RS03220	COG0708	Exodeoxyribonuclease III
DXY22_RS03225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DXY22_RS03230	COG0629	single-stranded DNA binding
DXY22_RS03235	COG0360	Binds together with S18 to 16S ribosomal RNA
DXY22_RS03240	COG0012	GTP binding
DXY22_RS03245	COG0243	molybdopterin cofactor binding
DXY22_RS03250	COG4481	Protein conserved in bacteria
DXY22_RS03255	COG3949	Membrane
DXY22_RS03265	COG1475	DNA binding
DXY22_RS03270	COG1192	Involved in chromosome partitioning
DXY22_RS03280	COG1475	DNA binding
DXY22_RS03285	COG0357	Ribosomal RNA small subunit methyltransferase G
DXY22_RS03290	COG0445	tRNA wobble uridine modification
DXY22_RS03295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DXY22_RS03300	COG1847	R3H domain protein
DXY22_RS03305	COG0706	membrane insertase activity
DXY22_RS03310	COG0594	ribonuclease P activity
DXY22_RS03315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DXY22_RS03320	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DXY22_RS03325	COG0592	DNA-directed DNA polymerase activity
DXY22_RS03330	COG2501	S4 domain
DXY22_RS03335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DXY22_RS03345	COG0187	DNA topoisomerase II activity
DXY22_RS03350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY22_RS03385	COG0517	IMP dehydrogenase activity
DXY22_RS03385	COG0516	GMP reductase activity
DXY22_RS03390	COG1686	Belongs to the peptidase S11 family
DXY22_RS03395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DXY22_RS03400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DXY22_RS03405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DXY22_RS03415	COG1428	Deoxynucleoside kinase
DXY22_RS03420	COG1428	Deoxynucleoside kinase
DXY22_RS03425	COG1388	LysM domain
DXY22_RS03425	COG3858	chitin binding
DXY22_RS03430	COG1335	isochorismatase
DXY22_RS03435	COG0590	tRNA wobble adenosine to inosine editing
DXY22_RS03445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DXY22_RS03450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DXY22_RS03455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DXY22_RS03500	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DXY22_RS03505	COG3853	Toxic anion resistance protein (TelA)
DXY22_RS03510	COG1982	Orn Lys Arg decarboxylase major
DXY22_RS03515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DXY22_RS03520	COG3870	Protein conserved in bacteria
DXY22_RS03525	COG1728	Protein conserved in bacteria
DXY22_RS03530	COG0470	DNA polymerase III
DXY22_RS03535	COG1774	PSP1 C-terminal conserved region
DXY22_RS03540	COG4467	Involved in initiation control of chromosome replication
DXY22_RS03545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DXY22_RS03550	COG2827	Endonuclease containing a URI domain
DXY22_RS03555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DXY22_RS03560	COG2002	toxin-antitoxin pair type II binding
DXY22_RS03565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_RS03565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_RS03570	COG0084	hydrolase, TatD family'
DXY22_RS03575	COG3584	3D domain protein
DXY22_RS03575	COG3583	domain protein
DXY22_RS03580	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY22_RS03585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DXY22_RS03595	COG4466	Protein conserved in bacteria
DXY22_RS03605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DXY22_RS03610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_RS03615	COG0251	oxidation-reduction process
DXY22_RS03620	COG2088	sporulation resulting in formation of a cellular spore
DXY22_RS03625	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DXY22_RS03630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DXY22_RS03635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DXY22_RS03640	COG0193	aminoacyl-tRNA hydrolase activity
DXY22_RS03650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DXY22_RS03655	COG2002	toxin-antitoxin pair type II binding
DXY22_RS03660	COG2244	polysaccharide biosynthetic process
DXY22_RS03665	COG3956	TIGRFAM MazG family protein
DXY22_RS03670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DXY22_RS03685	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DXY22_RS03690	COG1098	S1 RNA binding domain
DXY22_RS03705	COG2208	phosphoserine phosphatase activity
DXY22_RS03710	COG2304	oxidoreductase activity
DXY22_RS03715	COG0515	serine threonine protein kinase
DXY22_RS03720	COG0037	tRNA processing
DXY22_RS03730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DXY22_RS03735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DXY22_RS03740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DXY22_RS03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY22_RS03750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_RS03755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY22_RS03760	COG0512	Glutamine amidotransferase of anthranilate synthase
DXY22_RS03765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_RS03770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DXY22_RS03775	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DXY22_RS03780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DXY22_RS03785	COG1396	sequence-specific DNA binding
DXY22_RS03790	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY22_RS03795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DXY22_RS03875	COG4463	regulation of RNA biosynthetic process
DXY22_RS03880	COG3880	PFAM UvrB UvrC protein
DXY22_RS03885	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DXY22_RS03890	COG0542	response to heat
DXY22_RS03895	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DXY22_RS03900	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DXY22_RS03905	COG4956	integral membrane protein (PIN domain superfamily)
DXY22_RS03910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DXY22_RS03915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DXY22_RS03920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DXY22_RS03925	COG1045	serine acetyltransferase
DXY22_RS03930	COG0215	cysteine-tRNA ligase activity
DXY22_RS03935	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DXY22_RS03940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY22_RS03945	COG3688	RNA-binding protein containing a PIN domain
DXY22_RS03950	COG1595	DNA-templated transcription, initiation
DXY22_RS03955	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DXY22_RS03960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY22_RS03965	COG0250	Participates in transcription elongation, termination and antitermination
DXY22_RS03970	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DXY22_RS03975	COG0081	regulation of translation
DXY22_RS03980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DXY22_RS03985	COG0222	ribosome binding
DXY22_RS03990	COG2813	Specifically methylates the guanine in position
DXY22_RS03995	COG0085	RNA polymerase activity
DXY22_RS04000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DXY22_RS04005	COG1358	cellular component organization or biogenesis
DXY22_RS04010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DXY22_RS04015	COG0049	tRNA binding
DXY22_RS04020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DXY22_RS04025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DXY22_RS04030	COG0596	Alpha beta hydrolase
DXY22_RS04035	COG0051	transcription antitermination factor activity, RNA binding
DXY22_RS04040	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DXY22_RS04045	COG0088	Forms part of the polypeptide exit tunnel
DXY22_RS04050	COG0089	rRNA binding
DXY22_RS04055	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DXY22_RS04060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DXY22_RS04065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DXY22_RS04070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DXY22_RS04075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DXY22_RS04080	COG0255	Belongs to the universal ribosomal protein uL29 family
DXY22_RS04085	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DXY22_RS04090	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DXY22_RS04100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DXY22_RS04110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DXY22_RS04115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DXY22_RS04120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DXY22_RS04125	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DXY22_RS04130	COG1841	ribosomal large subunit assembly
DXY22_RS04135	COG0200	Binds to the 23S rRNA
DXY22_RS04140	COG0201	protein transport
DXY22_RS04145	COG0563	adenylate kinase activity
DXY22_RS04150	COG0024	Methionine aminopeptidase
DXY22_RS04155	COG2163	COG2163 Ribosomal protein L14E L6E L27E
DXY22_RS04160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DXY22_RS04165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DXY22_RS04170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DXY22_RS04175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DXY22_RS04180	COG0202	RNA polymerase activity
DXY22_RS04185	COG0203	ribosomal protein L17
DXY22_RS04190	COG1122	ATPase activity
DXY22_RS04195	COG1122	ATPase activity
DXY22_RS04200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY22_RS04205	COG0101	tRNA pseudouridine synthase activity
DXY22_RS04210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DXY22_RS04215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DXY22_RS04220	COG2226	methyltransferase
DXY22_RS04230	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS04235	COG0489	protein tyrosine kinase activity
DXY22_RS04245	COG2194	sulfuric ester hydrolase activity
DXY22_RS04250	COG0726	polysaccharide deacetylase
DXY22_RS04315	COG0659	secondary active sulfate transmembrane transporter activity
DXY22_RS04320	COG0385	Bile acid
DXY22_RS04325	COG2819	hydrolase of the alpha beta superfamily
DXY22_RS04330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS04335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS04340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS04345	COG2207	Transcriptional regulator
DXY22_RS04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS04350	COG3876	Protein conserved in bacteria
DXY22_RS04355	COG1472	Belongs to the glycosyl hydrolase 3 family
DXY22_RS04360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_RS04365	COG1263	PTS System
DXY22_RS04365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS04370	COG1737	Transcriptional regulator
DXY22_RS04375	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DXY22_RS04380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS04385	COG1683	Conserved Protein
DXY22_RS04415	COG1595	DNA-templated transcription, initiation
DXY22_RS04420	COG5662	AntiSigma factor
DXY22_RS04425	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY22_RS04430	COG4856	YbbR-like protein
DXY22_RS04435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DXY22_RS04445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DXY22_RS04455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DXY22_RS04460	COG2169	Transcriptional regulator
DXY22_RS04465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY22_RS04470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DXY22_RS04475	COG3002	Belongs to the UPF0753 family
DXY22_RS04480	COG0288	reversible hydration of carbon dioxide
DXY22_RS04490	COG5609	conserved protein (DUF2294)
DXY22_RS04495	COG0640	Transcriptional regulator
DXY22_RS04500	COG2814	Major facilitator Superfamily
DXY22_RS04505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DXY22_RS04515	COG0535	radical SAM domain protein
DXY22_RS04520	COG1266	CAAX protease self-immunity
DXY22_RS04525	COG1131	(ABC) transporter
DXY22_RS04535	COG1413	lyase activity
DXY22_RS04540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS04545	COG0596	Alpha beta hydrolase
DXY22_RS04550	COG0745	RESPONSE REGULATOR receiver
DXY22_RS04555	COG0642	Histidine kinase
DXY22_RS04565	COG0515	serine threonine protein kinase
DXY22_RS04580	COG1113	amino acid transport
DXY22_RS04595	COG2602	Beta-lactamase
DXY22_RS04600	COG2124	cytochrome p450
DXY22_RS04610	COG0531	amino acid
DXY22_RS04615	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_RS04620	COG2271	Major facilitator Superfamily
DXY22_RS04630	COG1846	Transcriptional regulator
DXY22_RS04630	COG0456	acetyltransferase
DXY22_RS04635	COG2271	Major facilitator Superfamily
DXY22_RS04645	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS04650	COG0697	spore germination
DXY22_RS04655	COG2207	Transcriptional regulator
DXY22_RS04655	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS04660	COG1397	ADP-ribosylglycohydrolase
DXY22_RS04665	COG5444	nuclease activity
DXY22_RS04670	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DXY22_RS04675	COG3591	Belongs to the peptidase S1B family
DXY22_RS04685	COG0596	Alpha beta hydrolase
DXY22_RS04690	COG1183	phosphatidylcholine synthase activity
DXY22_RS04695	COG0586	Pfam SNARE associated Golgi protein
DXY22_RS04700	COG0688	phosphatidylethanolamine metabolic process
DXY22_RS04710	COG2312	Erythromycin esterase
DXY22_RS04720	COG1301	dicarboxylic acid transport
DXY22_RS04725	COG1263	PTS System
DXY22_RS04725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS04725	COG2190	(PTS) system
DXY22_RS04730	COG0363	glucosamine-6-phosphate deaminase activity
DXY22_RS04745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_RS04750	COG0833	amino acid
DXY22_RS04755	COG2040	homocysteine
DXY22_RS04765	COG1115	amino acid carrier protein
DXY22_RS04770	COG2066	Belongs to the glutaminase family
DXY22_RS04775	COG4191	Histidine kinase
DXY22_RS04780	COG0784	Response regulator, receiver
DXY22_RS04785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DXY22_RS04790	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS04795	COG2271	Major facilitator Superfamily
DXY22_RS04800	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_RS04805	COG2186	Transcriptional regulator
DXY22_RS04810	COG2721	sulfolactate sulfo-lyase activity
DXY22_RS04815	COG3173	Aminoglycoside phosphotransferase
DXY22_RS04825	COG0697	spore germination
DXY22_RS04830	COG0745	RESPONSE REGULATOR receiver
DXY22_RS04835	COG2205	protein histidine kinase activity
DXY22_RS04840	COG1131	(ABC) transporter
DXY22_RS04860	COG3773	Cell wall hydrolase
DXY22_RS04865	COG2304	oxidoreductase activity
DXY22_RS04875	COG3540	Alkaline phosphatase
DXY22_RS04880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_RS04885	COG0805	protein transport
DXY22_RS04890	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DXY22_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY22_RS04900	COG0477	Major facilitator Superfamily
DXY22_RS04905	COG1309	transcriptional regulator
DXY22_RS04910	COG0252	asparaginase activity
DXY22_RS04915	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DXY22_RS04920	COG1714	RDD family
DXY22_RS04925	COG3012	SEC-C Motif Domain Protein
DXY22_RS04925	COG1405	negative regulation of cell septum assembly
DXY22_RS04930	COG3290	protein histidine kinase activity
DXY22_RS04935	COG3279	Response regulator of the LytR AlgR family
DXY22_RS04940	COG4555	ABC transporter
DXY22_RS04945	COG1668	transmembrane transport
DXY22_RS04950	COG0667	Aldo Keto reductase
DXY22_RS04965	COG1595	DNA-templated transcription, initiation
DXY22_RS04970	COG1595	DNA-templated transcription, initiation
DXY22_RS04975	COG1876	peptidase activity
DXY22_RS04980	COG0457	Tetratricopeptide repeat
DXY22_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS04990	COG0366	Alpha amylase catalytic
DXY22_RS04995	COG0803	Belongs to the bacterial solute-binding protein 9 family
DXY22_RS05000	COG1121	(ABC) transporter
DXY22_RS05005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_RS05010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS05015	COG2310	stress, protein
DXY22_RS05020	COG2310	stress, protein
DXY22_RS05025	COG2310	stress, protein
DXY22_RS05030	COG0861	Integral membrane protein TerC family
DXY22_RS05040	COG3853	Toxic anion resistance protein (TelA)
DXY22_RS05045	COG0477	Major facilitator Superfamily
DXY22_RS05050	COG2814	Major facilitator Superfamily
DXY22_RS05055	COG0640	Transcriptional regulator
DXY22_RS05060	COG0517	IMP dehydrogenase activity
DXY22_RS05060	COG4175	Glycine betaine
DXY22_RS05065	COG4176	ABC-type proline glycine betaine transport system permease component
DXY22_RS05070	COG2113	Glycine betaine
DXY22_RS05075	COG1473	amidohydrolase
DXY22_RS05080	COG1288	antiporter activity
DXY22_RS05090	COG0366	Alpha amylase catalytic
DXY22_RS05095	COG0039	L-malate dehydrogenase activity
DXY22_RS05100	COG1620	l-lactate permease
DXY22_RS05105	COG2814	Major facilitator Superfamily
DXY22_RS05110	COG1846	Transcriptional regulator
DXY22_RS05115	COG1280	lysine exporter protein (LysE YggA)
DXY22_RS05120	COG3403	YqcI/YcgG family
DXY22_RS05125	COG1113	amino acid transport
DXY22_RS05130	COG3665	Urea carboxylase-associated protein
DXY22_RS05135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DXY22_RS05140	COG1660	Displays ATPase and GTPase activities
DXY22_RS05145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DXY22_RS05150	COG2226	methyltransferase
DXY22_RS05155	COG0583	DNA-binding transcription factor activity
DXY22_RS05160	COG3458	cephalosporin-C deacetylase activity
DXY22_RS05165	COG3541	Predicted nucleotidyltransferase
DXY22_RS05170	COG0506	proline dehydrogenase activity
DXY22_RS05175	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS05180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_RS05185	COG2508	Transcriptional regulator
DXY22_RS05190	COG3689	TIGRFAM TIGR03943 family protein
DXY22_RS05195	COG0701	Predicted permease
DXY22_RS05200	COG2267	carboxylic ester hydrolase activity
DXY22_RS05205	COG0492	ferredoxin-NADP+ reductase activity
DXY22_RS05210	COG1587	Uroporphyrinogen-III synthase
DXY22_RS05210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY22_RS05215	COG2146	nitrite reductase [NAD(P)H] activity
DXY22_RS05220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_RS05225	COG0243	molybdopterin cofactor binding
DXY22_RS05230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_RS05235	COG2223	nitrite transmembrane transporter activity
DXY22_RS05240	COG1469	GTP cyclohydrolase I activity
DXY22_RS05245	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_RS05260	COG0523	cobalamin synthesis protein
DXY22_RS05265	COG0765	amino acid transport
DXY22_RS05270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS05290	COG1846	Transcriptional regulator
DXY22_RS05305	COG2723	6-phospho-beta-galactosidase activity
DXY22_RS05315	COG3209	COG3209 Rhs family protein
DXY22_RS05320	COG3290	protein histidine kinase activity
DXY22_RS05320	COG0840	transmembrane signaling receptor activity
DXY22_RS05325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DXY22_RS05330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DXY22_RS05335	COG1733	regulation of RNA biosynthetic process
DXY22_RS05340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS05345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS05350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS05355	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DXY22_RS05360	COG2814	Major facilitator Superfamily
DXY22_RS05370	COG0697	spore germination
DXY22_RS05375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS05385	COG2364	Membrane
DXY22_RS05390	COG1126	abc transporter atp-binding protein
DXY22_RS05395	COG0765	amino acid transport
DXY22_RS05400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS05405	COG0583	DNA-binding transcription factor activity
DXY22_RS05410	COG0163	prenyltransferase activity
DXY22_RS05415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DXY22_RS05430	COG0596	Alpha beta hydrolase
DXY22_RS05435	COG3104	oligopeptide transport
DXY22_RS05440	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY22_RS05450	COG0697	spore germination
DXY22_RS05460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY22_RS05465	COG1136	(ABC) transporter
DXY22_RS05470	COG0577	efflux transmembrane transporter activity
DXY22_RS05475	COG0745	RESPONSE REGULATOR receiver
DXY22_RS05480	COG5002	protein histidine kinase activity
DXY22_RS05480	COG3850	Histidine kinase
DXY22_RS05485	COG0457	Tetratricopeptide repeat
DXY22_RS05505	COG0527	aspartate kinase activity
DXY22_RS05510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS05515	COG4605	iron ion homeostasis
DXY22_RS05520	COG4604	ABC transporter, ATP-binding protein
DXY22_RS05525	COG4607	ABC-type enterochelin transport system periplasmic component
DXY22_RS05530	COG2814	Major facilitator Superfamily
DXY22_RS05535	COG1309	transcriptional regulator
DXY22_RS05540	COG0778	Nitroreductase
DXY22_RS05545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY22_RS05550	COG0640	Transcriptional regulator
DXY22_RS05555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS05560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DXY22_RS05565	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS05570	COG4975	Glucose uptake
DXY22_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS05580	COG4549	nuclear export factor GLE1
DXY22_RS05585	COG2372	response to copper ion
DXY22_RS05585	COG1276	copper resistance
DXY22_RS05590	COG1349	DNA-binding transcription factor activity
DXY22_RS05600	COG2213	PTS system mannitol-specific
DXY22_RS05605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS05610	COG0246	Mannitol dehydrogenase
DXY22_RS05615	COG0473	3-isopropylmalate dehydrogenase activity
DXY22_RS05620	COG0681	Belongs to the peptidase S26 family
DXY22_RS05625	COG0412	Dienelactone hydrolase
DXY22_RS05630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DXY22_RS05640	COG0561	phosphatase activity
DXY22_RS05645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DXY22_RS05650	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY22_RS05655	COG4336	lyase activity
DXY22_RS05660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DXY22_RS05665	COG1984	allophanate hydrolase subunit 2
DXY22_RS05670	COG1414	Transcriptional regulator
DXY22_RS05675	COG2755	lipolytic protein G-D-S-L family
DXY22_RS05685	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_RS05690	COG0768	penicillin binding
DXY22_RS05695	COG4989	oxidoreductase activity
DXY22_RS05700	COG3711	transcriptional antiterminator
DXY22_RS05705	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS05710	COG2226	methyltransferase
DXY22_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS05720	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS05725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS05730	COG3871	stress protein (general stress protein 26)
DXY22_RS05740	COG2814	Major facilitator Superfamily
DXY22_RS05745	COG1522	sequence-specific DNA binding
DXY22_RS05750	COG0551	DNA topoisomerase type I activity
DXY22_RS05750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY22_RS05755	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DXY22_RS05760	COG3706	GGDEF domain
DXY22_RS05765	COG5298	Protein conserved in bacteria
DXY22_RS05770	COG1215	transferase activity, transferring glycosyl groups
DXY22_RS05780	COG0531	amino acid
DXY22_RS05790	COG0028	Belongs to the TPP enzyme family
DXY22_RS05805	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY22_RS05810	COG2261	transglycosylase associated protein
DXY22_RS05815	COG4876	unkown
DXY22_RS05820	COG2217	Heavy metal translocating P-type atpase
DXY22_RS05825	COG3729	General stress protein
DXY22_RS05830	COG0662	Cupin 2, conserved barrel domain protein
DXY22_RS05835	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_RS05840	COG3546	catalase activity
DXY22_RS05845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DXY22_RS05850	COG3290	protein histidine kinase activity
DXY22_RS05855	COG4565	transcriptional regulatory protein
DXY22_RS05860	COG1301	dicarboxylic acid transport
DXY22_RS05865	COG0628	permease
DXY22_RS05870	COG1131	(ABC) transporter
DXY22_RS05875	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_RS05885	COG1960	acyl-CoA dehydrogenase activity
DXY22_RS05900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_RS05905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS05910	COG1181	Belongs to the D-alanine--D-alanine ligase family
DXY22_RS05915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DXY22_RS05920	COG0513	Belongs to the DEAD box helicase family
DXY22_RS05925	COG3402	PFAM membrane-flanked domain
DXY22_RS05930	COG3428	Bacterial PH domain
DXY22_RS05935	COG0705	Rhomboid family
DXY22_RS05940	COG0736	holo-[acyl-carrier-protein] synthase activity
DXY22_RS05945	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DXY22_RS05950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY22_RS05955	COG0864	Transcriptional regulator
DXY22_RS05960	COG2337	Toxic component of a toxin-antitoxin (TA) module
DXY22_RS05965	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS05970	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS05975	COG2172	sigma factor antagonist activity
DXY22_RS05980	COG2208	phosphoserine phosphatase activity
DXY22_RS05985	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS05990	COG2172	sigma factor antagonist activity
DXY22_RS05995	COG1191	sigma factor activity
DXY22_RS06000	COG2208	phosphoserine phosphatase activity
DXY22_RS06005	COG2183	response to ionizing radiation
DXY22_RS06015	COG3091	SprT-like family
DXY22_RS06055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS06095	COG1476	TRANSCRIPTIONal
DXY22_RS06115	COG0693	protein deglycase activity
DXY22_RS06120	COG1278	Cold shock
DXY22_RS06125	COG1329	Transcriptional regulator
DXY22_RS06130	COG0697	spore germination
DXY22_RS06135	COG2207	Transcriptional regulator
DXY22_RS06135	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS06140	COG0697	spore germination
DXY22_RS06145	COG3708	Transcriptional regulator
DXY22_RS06145	COG2207	Transcriptional regulator
DXY22_RS06150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS06155	COG0477	Major facilitator Superfamily
DXY22_RS06165	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DXY22_RS06175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS06180	COG1309	transcriptional regulator
DXY22_RS06185	COG0697	spore germination
DXY22_RS06190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS06195	COG2030	dehydratase
DXY22_RS06200	COG3545	Serine hydrolase
DXY22_RS06205	COG1733	regulation of RNA biosynthetic process
DXY22_RS06210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS06215	COG1733	regulation of RNA biosynthetic process
DXY22_RS06220	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_RS06225	COG2814	Major facilitator Superfamily
DXY22_RS06230	COG1309	transcriptional regulator
DXY22_RS06235	COG0640	Transcriptional regulator
DXY22_RS06240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY22_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS06255	COG0697	spore germination
DXY22_RS06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS06270	COG0640	Transcriptional regulator
DXY22_RS06275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DXY22_RS06290	COG4585	Histidine kinase
DXY22_RS06295	COG2197	response regulator
DXY22_RS06300	COG2409	Drug exporters of the RND superfamily
DXY22_RS06305	COG0596	Alpha beta hydrolase
DXY22_RS06310	COG1811	Na channel or pump
DXY22_RS06315	COG4978	Transcriptional regulator
DXY22_RS06315	COG0789	Transcriptional regulator
DXY22_RS06320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_RS06325	COG0778	Nitroreductase
DXY22_RS06330	COG0346	lactoylglutathione lyase activity
DXY22_RS06335	COG2259	Doxx family
DXY22_RS06340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS06355	COG2323	membrane
DXY22_RS06360	COG2323	membrane
DXY22_RS06365	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_RS06380	COG1309	transcriptional regulator
DXY22_RS06390	COG0456	acetyltransferase
DXY22_RS06400	COG1113	amino acid transport
DXY22_RS06405	COG2318	DinB family
DXY22_RS06410	COG1846	Transcriptional regulator
DXY22_RS06415	COG1033	growth of symbiont in host cell
DXY22_RS06415	COG2409	Drug exporters of the RND superfamily
DXY22_RS06420	COG0778	Nitroreductase
DXY22_RS06425	COG1846	Transcriptional regulator
DXY22_RS06430	COG2814	Major facilitator Superfamily
DXY22_RS06435	COG0730	response to heat
DXY22_RS06440	COG1802	Transcriptional regulator
DXY22_RS06445	COG1388	LysM domain
DXY22_RS06445	COG3858	chitin binding
DXY22_RS06450	COG1819	glycosyl
DXY22_RS06460	COG1785	Belongs to the alkaline phosphatase family
DXY22_RS06465	COG5646	InterPro IPR014922
DXY22_RS06475	COG0454	-acetyltransferase
DXY22_RS06480	COG1078	dGTPase activity
DXY22_RS06485	COG1388	LysM domain
DXY22_RS06490	COG2814	Major facilitator Superfamily
DXY22_RS06495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_RS06500	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY22_RS06505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_RS06510	COG2723	6-phospho-beta-galactosidase activity
DXY22_RS06515	COG2188	Transcriptional regulator
DXY22_RS06520	COG1940	carbohydrate kinase activity
DXY22_RS06525	COG1482	cell wall glycoprotein biosynthetic process
DXY22_RS06530	COG4124	Belongs to the glycosyl hydrolase 26 family
DXY22_RS06575	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DXY22_RS06580	COG0802	atpase or kinase
DXY22_RS06585	COG1214	PFAM Peptidase M22, glycoprotease
DXY22_RS06590	COG0456	acetyltransferase
DXY22_RS06595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DXY22_RS06600	COG0488	(ABC) transporter
DXY22_RS06605	COG0315	cyclic pyranopterin monophosphate synthase activity
DXY22_RS06610	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DXY22_RS06615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_RS06620	COG0805	protein transport
DXY22_RS06630	COG1266	CAAX protease self-immunity
DXY22_RS06635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DXY22_RS06640	COG0459	protein refolding
DXY22_RS06650	COG1073	alpha beta
DXY22_RS06655	COG0457	Tetratricopeptide repeat
DXY22_RS06660	COG1063	alcohol dehydrogenase
DXY22_RS06665	COG2211	Major facilitator Superfamily
DXY22_RS06670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_RS06675	COG1842	Phage shock protein A
DXY22_RS06680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY22_RS06685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DXY22_RS06690	COG4260	virion core protein, lumpy skin disease virus
DXY22_RS06700	COG2814	Major facilitator Superfamily
DXY22_RS06705	COG1063	alcohol dehydrogenase
DXY22_RS06710	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DXY22_RS06715	COG0823	Involved in the tonB-independent uptake of proteins
DXY22_RS06730	COG2267	carboxylic ester hydrolase activity
DXY22_RS06740	COG2132	Multicopper oxidase
DXY22_RS06745	COG1113	amino acid transport
DXY22_RS06755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_RS06760	COG0714	Associated with various cellular activities
DXY22_RS06765	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DXY22_RS06770	COG1305	Transglutaminase-like
DXY22_RS06775	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DXY22_RS06775	COG0519	Catalyzes the synthesis of GMP from XMP
DXY22_RS06790	COG2252	PERMEase
DXY22_RS06795	COG3064	Membrane
DXY22_RS06805	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DXY22_RS06815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DXY22_RS06820	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DXY22_RS06825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DXY22_RS06830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DXY22_RS06835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DXY22_RS06840	COG0047	phosphoribosylformylglycinamidine synthase activity
DXY22_RS06845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DXY22_RS06850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DXY22_RS06855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DXY22_RS06860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DXY22_RS06865	COG0138	bifunctional purine biosynthesis protein purh
DXY22_RS06870	COG0151	Belongs to the GarS family
DXY22_RS06875	COG1522	sequence-specific DNA binding
DXY22_RS06880	COG0531	amino acid
DXY22_RS06890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DXY22_RS06895	COG1470	cell adhesion involved in biofilm formation
DXY22_RS06900	COG4496	protein, YerC YecD
DXY22_RS06905	COG0069	glutamate synthase activity
DXY22_RS06910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DXY22_RS06915	COG0210	DNA helicase
DXY22_RS06920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DXY22_RS06925	COG4851	CamS sex pheromone cAM373 precursor
DXY22_RS06930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_RS06935	COG1285	pathogenesis
DXY22_RS06940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_RS06945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DXY22_RS06950	COG0154	amidase activity
DXY22_RS06955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DXY22_RS06960	COG1309	transcriptional regulator
DXY22_RS06965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DXY22_RS06970	COG1597	lipid kinase activity
DXY22_RS06975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY22_RS06980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DXY22_RS06990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DXY22_RS07015	COG3391	amine dehydrogenase activity
DXY22_RS07030	COG0457	Tetratricopeptide repeat
DXY22_RS07040	COG0217	transcriptional regulatory protein
DXY22_RS07050	COG1309	transcriptional regulator
DXY22_RS07055	COG3631	Ketosteroid isomerase-related protein
DXY22_RS07060	COG0702	epimerase
DXY22_RS07075	COG3546	catalase activity
DXY22_RS07080	COG0454	-acetyltransferase
DXY22_RS07090	COG5578	integral membrane protein
DXY22_RS07095	COG2972	Histidine kinase
DXY22_RS07100	COG4753	response regulator
DXY22_RS07100	COG2207	Transcriptional regulator
DXY22_RS07105	COG1653	transport
DXY22_RS07110	COG1175	transmembrane transport
DXY22_RS07115	COG0395	ABC-type sugar transport system, permease component
DXY22_RS07120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DXY22_RS07125	COG2207	Transcriptional regulator
DXY22_RS07130	COG2755	lipolytic protein G-D-S-L family
DXY22_RS07140	COG5578	integral membrane protein
DXY22_RS07145	COG3401	FG-GAP repeat protein
DXY22_RS07150	COG3401	FG-GAP repeat protein
DXY22_RS07155	COG2755	lipolytic protein G-D-S-L family
DXY22_RS07160	COG1874	Beta-galactosidase
DXY22_RS07170	COG1653	transport
DXY22_RS07175	COG4209	transmembrane transport
DXY22_RS07180	COG0395	ABC-type sugar transport system, permease component
DXY22_RS07185	COG1486	melibiose metabolic process
DXY22_RS07190	COG2323	membrane
DXY22_RS07195	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_RS07200	COG0346	lactoylglutathione lyase activity
DXY22_RS07215	COG5583	Uncharacterized small protein (DUF2292)
DXY22_RS07220	COG0670	Belongs to the BI1 family
DXY22_RS07225	COG0697	spore germination
DXY22_RS07230	COG1846	Transcriptional regulator
DXY22_RS07235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DXY22_RS07245	COG2124	cytochrome p450
DXY22_RS07245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_RS07250	COG1368	sulfuric ester hydrolase activity
DXY22_RS07255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DXY22_RS07260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_RS07265	COG1442	glycosyl transferase family 8
DXY22_RS07270	COG1216	Glycosyl transferase, family 2
DXY22_RS07275	COG1442	glycosyl transferase family 8
DXY22_RS07280	COG2223	nitrite transmembrane transporter activity
DXY22_RS07285	COG1011	Hydrolase
DXY22_RS07290	COG0531	amino acid
DXY22_RS07295	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS07300	COG0840	transmembrane signaling receptor activity
DXY22_RS07305	COG0488	(ABC) transporter
DXY22_RS07315	COG0789	Transcriptional regulator
DXY22_RS07320	COG2814	Major facilitator Superfamily
DXY22_RS07335	COG0488	(ABC) transporter
DXY22_RS07340	COG0513	Belongs to the DEAD box helicase family
DXY22_RS07345	COG0456	acetyltransferase
DXY22_RS07350	COG2130	NADP-dependent
DXY22_RS07355	COG2211	Major facilitator Superfamily
DXY22_RS07360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DXY22_RS07365	COG1120	ATPase activity
DXY22_RS07370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS07375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS07380	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DXY22_RS07395	COG3866	Pectate lyase
DXY22_RS07400	COG0471	metal ion transport
DXY22_RS07405	COG3290	protein histidine kinase activity
DXY22_RS07410	COG4565	transcriptional regulatory protein
DXY22_RS07415	COG3181	Tripartite tricarboxylate transporter family receptor
DXY22_RS07420	COG2851	Citrate transporter
DXY22_RS07425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS07430	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DXY22_RS07435	COG1254	Belongs to the acylphosphatase family
DXY22_RS07440	COG2258	MOSC domain
DXY22_RS07460	COG0024	Methionine aminopeptidase
DXY22_RS07465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS07465	COG1263	PTS System
DXY22_RS07470	COG1368	sulfuric ester hydrolase activity
DXY22_RS07485	COG1115	amino acid carrier protein
DXY22_RS07505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS07505	COG1263	PTS System
DXY22_RS07510	COG0366	Alpha amylase catalytic
DXY22_RS07515	COG2188	Transcriptional regulator
DXY22_RS07520	COG0778	Nitroreductase
DXY22_RS07525	COG0737	Belongs to the 5'-nucleotidase family
DXY22_RS07530	COG0693	protein deglycase activity
DXY22_RS07535	COG2814	Major facilitator Superfamily
DXY22_RS07540	COG4840	Belongs to the UPF0435 family
DXY22_RS07545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY22_RS07550	COG4980	gas vesicle protein
DXY22_RS07555	COG1295	ribonuclease BN
DXY22_RS07560	COG0477	Major facilitator Superfamily
DXY22_RS07565	COG0387	Pfam Sodium calcium exchanger
DXY22_RS07575	COG0668	transmembrane transport
DXY22_RS07580	COG0535	radical SAM domain protein
DXY22_RS07590	COG0726	polysaccharide deacetylase
DXY22_RS07595	COG2084	Dehydrogenase
DXY22_RS07600	COG0598	Magnesium transport protein CorA
DXY22_RS07605	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DXY22_RS07610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY22_RS07620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY22_RS07625	COG4637	Psort location Cytoplasmic, score
DXY22_RS07635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_RS07640	COG0022	dehydrogenase e1 component
DXY22_RS07645	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_RS07650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_RS07655	COG3284	Transcriptional regulator
DXY22_RS07665	COG1742	UPF0060 membrane protein
DXY22_RS07685	COG4842	Belongs to the WXG100 family
DXY22_RS07690	COG1486	melibiose metabolic process
DXY22_RS07695	COG1737	Transcriptional regulator
DXY22_RS07700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS07700	COG1263	PTS System
DXY22_RS07705	COG1132	(ABC) transporter
DXY22_RS07710	COG1132	(ABC) transporter
DXY22_RS07715	COG2259	Doxx family
DXY22_RS07720	COG2514	catechol 2,3-dioxygenase activity
DXY22_RS07725	COG4585	Histidine kinase
DXY22_RS07730	COG2197	response regulator
DXY22_RS07735	COG1131	(ABC) transporter
DXY22_RS07740	COG1511	domain protein
DXY22_RS07740	COG0842	Transport permease protein
DXY22_RS07745	COG0842	Transport permease protein
DXY22_RS07750	COG1695	Transcriptional regulator
DXY22_RS07755	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DXY22_RS07760	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DXY22_RS07765	COG2318	DinB family
DXY22_RS07770	COG2814	Major facilitator Superfamily
DXY22_RS07775	COG1846	Transcriptional regulator
DXY22_RS07780	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DXY22_RS07780	COG0392	lysyltransferase activity
DXY22_RS07785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS07795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS07800	COG0384	phenazine biosynthesis protein PhzF
DXY22_RS07805	COG0778	Nitroreductase
DXY22_RS07820	COG1090	epimerase
DXY22_RS07825	COG2137	regulation of response to DNA damage stimulus
DXY22_RS07835	COG2814	Major facilitator Superfamily
DXY22_RS07850	COG3103	Sh3 type 3 domain protein
DXY22_RS07855	COG5658	integral membrane protein
DXY22_RS07860	COG0596	Alpha beta hydrolase
DXY22_RS07865	COG0463	Glycosyl transferase, family 2
DXY22_RS07870	COG4485	Bacterial membrane protein, YfhO
DXY22_RS07875	COG1988	membrane-bound metal-dependent
DXY22_RS07880	COG1194	a g-specific adenine glycosylase
DXY22_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS07905	COG3557	Belongs to the UPF0374 family
DXY22_RS07910	COG1132	(ABC) transporter
DXY22_RS07915	COG4129	membrane
DXY22_RS07920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DXY22_RS07925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DXY22_RS07930	COG0735	belongs to the Fur family
DXY22_RS08040	COG4326	sporulation control protein
DXY22_RS08050	COG5577	PFAM Coat F domain
DXY22_RS08055	COG3340	Belongs to the peptidase S51 family
DXY22_RS08060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DXY22_RS08065	COG0277	FAD linked oxidase domain protein
DXY22_RS08075	COG0753	catalase activity
DXY22_RS08080	COG1116	anion transmembrane transporter activity
DXY22_RS08085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY22_RS08090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY22_RS08095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS08105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DXY22_RS08115	COG1476	TRANSCRIPTIONal
DXY22_RS08125	COG3382	B3 4 domain protein
DXY22_RS08130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DXY22_RS08140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DXY22_RS08145	COG0789	Transcriptional regulator
DXY22_RS08150	COG1664	Polymer-forming cytoskeletal
DXY22_RS08155	COG1664	Polymer-forming cytoskeletal
DXY22_RS08160	COG2766	serine protein kinase
DXY22_RS08165	COG2718	Belongs to the UPF0229 family
DXY22_RS08170	COG1846	Transcriptional regulator
DXY22_RS08175	COG1566	PFAM secretion protein HlyD family protein
DXY22_RS08180	COG2814	Major facilitator Superfamily
DXY22_RS08185	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY22_RS08205	COG1725	Transcriptional regulator
DXY22_RS08210	COG1131	(ABC) transporter
DXY22_RS08215	COG1131	(ABC) transporter
DXY22_RS08220	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_RS08225	COG1278	Cold shock
DXY22_RS08230	COG1464	Belongs to the NlpA lipoprotein family
DXY22_RS08235	COG3706	GGDEF domain
DXY22_RS08240	COG1823	symporter activity
DXY22_RS08260	COG5577	PFAM Coat F domain
DXY22_RS08265	COG4085	toxin activity
DXY22_RS08265	COG1525	nuclease
DXY22_RS08265	COG0737	Belongs to the 5'-nucleotidase family
DXY22_RS08270	COG3764	Sortase (surface protein transpeptidase)
DXY22_RS08275	COG0564	pseudouridine synthase activity
DXY22_RS08285	COG0517	IMP dehydrogenase activity
DXY22_RS08290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DXY22_RS08295	COG3153	acetyltransferase
DXY22_RS08295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY22_RS08300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_RS08305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DXY22_RS08310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DXY22_RS08315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DXY22_RS08320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DXY22_RS08325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DXY22_RS08330	COG4585	Histidine kinase
DXY22_RS08330	COG2203	Gaf domain
DXY22_RS08335	COG2197	response regulator
DXY22_RS08340	COG0431	NADPH-dependent FMN reductase
DXY22_RS08355	COG0791	NLP P60 protein
DXY22_RS08355	COG1388	LysM domain
DXY22_RS08360	COG1959	2 iron, 2 sulfur cluster binding
DXY22_RS08365	COG0668	transmembrane transport
DXY22_RS08370	COG2719	SpoVR family
DXY22_RS08375	COG1785	Belongs to the alkaline phosphatase family
DXY22_RS08380	COG1388	LysM domain
DXY22_RS08380	COG0791	NLP P60 protein
DXY22_RS08385	COG0583	DNA-binding transcription factor activity
DXY22_RS08390	COG0372	Belongs to the citrate synthase family
DXY22_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS08400	COG0531	amino acid
DXY22_RS08405	COG0733	neurotransmitter:sodium symporter activity
DXY22_RS08410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS08415	COG0456	acetyltransferase
DXY22_RS08430	COG1595	DNA-templated transcription, initiation
DXY22_RS08435	COG0667	Aldo Keto reductase
DXY22_RS08440	COG0204	Acyl-transferase
DXY22_RS08445	COG1253	flavin adenine dinucleotide binding
DXY22_RS08450	COG0789	Transcriptional regulator
DXY22_RS08455	COG0436	Aminotransferase
DXY22_RS08460	COG1253	flavin adenine dinucleotide binding
DXY22_RS08465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY22_RS08470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY22_RS08475	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_RS08485	COG0668	transmembrane transport
DXY22_RS08490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DXY22_RS08495	COG0726	polysaccharide deacetylase
DXY22_RS08500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_RS08505	COG1757	Na H antiporter
DXY22_RS08510	COG0589	response to stress
DXY22_RS08520	COG1132	(ABC) transporter
DXY22_RS08525	COG1132	(ABC) transporter
DXY22_RS08530	COG0702	epimerase
DXY22_RS08550	COG0189	ligase activity
DXY22_RS08555	COG0189	ligase activity
DXY22_RS08560	COG4399	Belongs to the UPF0754 family
DXY22_RS08565	COG3679	Belongs to the UPF0342 family
DXY22_RS08570	COG4335	DNA alkylation repair
DXY22_RS08575	COG0561	phosphatase activity
DXY22_RS08580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY22_RS08585	COG0475	glutathione-regulated potassium exporter activity
DXY22_RS08590	COG0490	domain, Protein
DXY22_RS08600	COG1024	Enoyl-CoA hydratase
DXY22_RS08610	COG4152	abc transporter atp-binding protein
DXY22_RS08615	COG1668	transmembrane transport
DXY22_RS08620	COG0420	3'-5' exonuclease activity
DXY22_RS08625	COG4717	serine-type aminopeptidase activity
DXY22_RS08630	COG3481	metal-dependent phosphohydrolase, HD sub domain
DXY22_RS08640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY22_RS08670	COG1846	Transcriptional regulator
DXY22_RS08675	COG4980	gas vesicle protein
DXY22_RS08690	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DXY22_RS08695	COG0537	adenosine 5'-monophosphoramidase activity
DXY22_RS08700	COG1131	(ABC) transporter
DXY22_RS08705	COG4473	ABC transporter
DXY22_RS08715	COG1473	amidohydrolase
DXY22_RS08720	COG3069	C4-dicarboxylate transmembrane transporter activity
DXY22_RS08730	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_RS08735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_RS08740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DXY22_RS08755	COG1309	transcriptional regulator
DXY22_RS08760	COG1511	domain protein
DXY22_RS08765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_RS08770	COG4377	Putative membrane peptidase family (DUF2324)
DXY22_RS08780	COG1363	Peptidase, m42
DXY22_RS08785	COG4405	Protein conserved in bacteria
DXY22_RS08790	COG1301	dicarboxylic acid transport
DXY22_RS08800	COG1234	tRNA 3'-trailer cleavage
DXY22_RS08805	COG0095	Lipoate-protein ligase
DXY22_RS08810	COG0702	epimerase
DXY22_RS08815	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS08825	COG0501	Belongs to the peptidase M48B family
DXY22_RS08835	COG0456	acetyltransferase
DXY22_RS08840	COG0604	alcohol dehydrogenase
DXY22_RS08845	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DXY22_RS08850	COG0406	alpha-ribazole phosphatase activity
DXY22_RS08855	COG0183	Belongs to the thiolase family
DXY22_RS08860	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS08865	COG1268	BioY protein
DXY22_RS08870	COG0840	transmembrane signaling receptor activity
DXY22_RS08875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_RS08875	COG0723	plastoquinol--plastocyanin reductase activity
DXY22_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS08890	COG4903	ComK protein
DXY22_RS08895	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS08905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_RS08920	COG0398	Pfam SNARE associated Golgi protein
DXY22_RS08925	COG0681	Belongs to the peptidase S26 family
DXY22_RS08930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DXY22_RS08935	COG1846	Transcriptional regulator
DXY22_RS08940	COG0738	Major facilitator superfamily
DXY22_RS08945	COG0673	inositol 2-dehydrogenase activity
DXY22_RS08950	COG0561	phosphatase activity
DXY22_RS08955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_RS08960	COG1609	Transcriptional regulator
DXY22_RS08965	COG3180	Ammonia monooxygenase
DXY22_RS08970	COG0477	Major facilitator Superfamily
DXY22_RS08970	COG2814	Major facilitator Superfamily
DXY22_RS08975	COG4533	DNA binding
DXY22_RS08985	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DXY22_RS08990	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DXY22_RS08995	COG1074	ATP-dependent DNA helicase activity
DXY22_RS09000	COG0420	3'-5' exonuclease activity
DXY22_RS09005	COG0419	ATPase involved in DNA repair
DXY22_RS09010	COG1403	HNH endonuclease
DXY22_RS09050	COG5337	Spore coat protein CotH
DXY22_RS09055	COG0179	Fumarylacetoacetate (FAA) hydrolase
DXY22_RS09065	COG1404	Belongs to the peptidase S8 family
DXY22_RS09075	COG0367	asparagine synthase
DXY22_RS09080	COG2318	DinB family
DXY22_RS09085	COG1562	ergosterol biosynthetic process
DXY22_RS09090	COG0534	Mate efflux family protein
DXY22_RS09095	COG1917	Cupin 2, conserved barrel domain protein
DXY22_RS09095	COG2207	Transcriptional regulator
DXY22_RS09100	COG1609	Transcriptional regulator
DXY22_RS09105	COG0673	inositol 2-dehydrogenase activity
DXY22_RS09110	COG2318	DinB family
DXY22_RS09115	COG1279	arginine transmembrane transporter activity
DXY22_RS09120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_RS09125	COG1357	PFAM Pentapeptide repeats (8 copies)
DXY22_RS09130	COG2267	carboxylic ester hydrolase activity
DXY22_RS09135	COG0529	Catalyzes the synthesis of activated sulfate
DXY22_RS09140	COG2046	Belongs to the sulfate adenylyltransferase family
DXY22_RS09145	COG0175	sulfate reduction
DXY22_RS09150	COG2045	Belongs to the ComB family
DXY22_RS09155	COG1809	phosphosulfolactate synthase activity
DXY22_RS09160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS09165	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_RS09170	COG2814	Major facilitator Superfamily
DXY22_RS09175	COG0454	-acetyltransferase
DXY22_RS09180	COG2153	protein acetylation
DXY22_RS09185	COG0646	methionine synthase
DXY22_RS09185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DXY22_RS09190	COG1666	GTP binding
DXY22_RS09195	COG2996	Protein conserved in bacteria
DXY22_RS09215	COG1695	Transcriptional regulator
DXY22_RS09230	COG3227	Zinc metalloprotease (Elastase)
DXY22_RS09235	COG1307	EDD domain protein, DegV family
DXY22_RS09240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS09255	COG0561	phosphatase activity
DXY22_RS09260	COG1073	alpha beta
DXY22_RS09265	COG2151	metal-sulfur cluster biosynthetic enzyme
DXY22_RS09280	COG2271	Major facilitator Superfamily
DXY22_RS09285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DXY22_RS09300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY22_RS09305	COG0505	Belongs to the CarA family
DXY22_RS09310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY22_RS09315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DXY22_RS09330	COG2267	carboxylic ester hydrolase activity
DXY22_RS09340	COG1744	ABC transporter substrate-binding protein PnrA-like
DXY22_RS09355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_RS09360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY22_RS09365	COG5504	Zn-dependent protease
DXY22_RS09370	COG0444	Belongs to the ABC transporter superfamily
DXY22_RS09375	COG4608	Belongs to the ABC transporter superfamily
DXY22_RS09385	COG0601	transmembrane transport
DXY22_RS09390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_RS09400	COG0180	Tryptophanyl-tRNA synthetase
DXY22_RS09405	COG4166	transmembrane transport
DXY22_RS09410	COG0601	transmembrane transport
DXY22_RS09415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_RS09420	COG0444	Belongs to the ABC transporter superfamily
DXY22_RS09425	COG4608	Belongs to the ABC transporter superfamily
DXY22_RS09430	COG2814	Major facilitator Superfamily
DXY22_RS09435	COG0456	acetyltransferase
DXY22_RS09440	COG1393	Belongs to the ArsC family
DXY22_RS09445	COG0861	Integral membrane protein TerC family
DXY22_RS09455	COG4862	establishment of competence for transformation
DXY22_RS09465	COG4469	Competence protein
DXY22_RS09470	COG1164	Oligoendopeptidase f
DXY22_RS09485	COG2346	COG2346, Truncated hemoglobins
DXY22_RS09490	COG0741	lytic transglycosylase activity
DXY22_RS09495	COG4116	CYTH
DXY22_RS09505	COG2357	RelA SpoT domain protein
DXY22_RS09510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY22_RS09515	COG0564	pseudouridine synthase activity
DXY22_RS09520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DXY22_RS09525	COG0569	domain protein
DXY22_RS09525	COG0475	glutathione-regulated potassium exporter activity
DXY22_RS09530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DXY22_RS09535	COG0352	thiamine-phosphate diphosphorylase activity
DXY22_RS09540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_RS09545	COG2104	thiamine diphosphate biosynthetic process
DXY22_RS09550	COG2022	thiamine diphosphate biosynthetic process
DXY22_RS09555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY22_RS09560	COG0351	phosphomethylpyrimidine kinase
DXY22_RS09565	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DXY22_RS09620	COG0210	DNA helicase
DXY22_RS09630	COG2153	protein acetylation
DXY22_RS09635	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DXY22_RS09640	COG2382	esterase
DXY22_RS09660	COG0626	cystathionine gamma-synthase activity
DXY22_RS09665	COG0626	cystathionine gamma-synthase activity
DXY22_RS09670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS09675	COG5505	Protein of unknown function (DUF819)
DXY22_RS09710	COG3677	Transposase
DXY22_RS09725	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY22_RS09740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS09740	COG3711	transcriptional antiterminator
DXY22_RS09745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS09745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_RS09745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_RS09750	COG1482	cell wall glycoprotein biosynthetic process
DXY22_RS09760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS09770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DXY22_RS09785	COG0109	protoheme IX farnesyltransferase activity
DXY22_RS09795	COG0726	polysaccharide deacetylase
DXY22_RS09810	COG5504	Zn-dependent protease
DXY22_RS09815	COG2205	protein histidine kinase activity
DXY22_RS09825	COG3383	formate dehydrogenase (NAD+) activity
DXY22_RS09830	COG2427	Protein of unknown function (DUF1641)
DXY22_RS09840	COG1051	belongs to the nudix hydrolase family
DXY22_RS09850	COG2124	cytochrome p450
DXY22_RS09855	COG1819	glycosyl
DXY22_RS09865	COG1587	Uroporphyrinogen-III synthase
DXY22_RS09870	COG0390	transport system, permease component
DXY22_RS09875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_RS09880	COG0697	spore germination
DXY22_RS09885	COG4297	protein containing double-stranded beta helix domain
DXY22_RS09895	COG1252	NADH dehydrogenase
DXY22_RS09900	COG1904	glucuronate isomerase
DXY22_RS09905	COG2211	Major facilitator Superfamily
DXY22_RS09910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DXY22_RS09915	COG1063	alcohol dehydrogenase
DXY22_RS09920	COG1312	Catalyzes the dehydration of D-mannonate
DXY22_RS09925	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS09930	COG2271	Major facilitator Superfamily
DXY22_RS09935	COG1609	Transcriptional regulator
DXY22_RS09940	COG0246	Mannitol dehydrogenase
DXY22_RS09945	COG2721	sulfolactate sulfo-lyase activity
DXY22_RS09950	COG0730	response to heat
DXY22_RS09955	COG2318	DinB family
DXY22_RS09960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DXY22_RS09965	COG0457	Tetratricopeptide repeat
DXY22_RS09975	COG2350	Protein conserved in bacteria
DXY22_RS09980	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS09980	COG1388	LysM domain
DXY22_RS09980	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS09990	COG4195	phage-related replication protein
DXY22_RS09995	COG3546	catalase activity
DXY22_RS10000	COG2856	Zn peptidase
DXY22_RS10005	COG1396	sequence-specific DNA binding
DXY22_RS10015	COG1522	sequence-specific DNA binding
DXY22_RS10020	COG1484	DNA-dependent DNA replication
DXY22_RS10040	COG1595	DNA-templated transcription, initiation
DXY22_RS10045	COG3728	DNA packaging
DXY22_RS10045	COG5484	DNA packaging
DXY22_RS10050	COG1783	phage Terminase large subunit
DXY22_RS10055	COG5518	Phage portal protein
DXY22_RS10060	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DXY22_RS10065	COG4653	Phage capsid family
DXY22_RS10115	COG3953	SLT domain
DXY22_RS10115	COG3953	SLT domain
DXY22_RS10115	COG5412	phage tail tape measure protein
DXY22_RS10115	COG5412	phage tail tape measure protein
DXY22_RS10120	COG1652	LysM domain
DXY22_RS10125	COG4193	domain, Protein
DXY22_RS10135	COG3628	GPW Gp25 family protein
DXY22_RS10140	COG3299	homolog of phage Mu protein gp47
DXY22_RS10145	COG3778	Protein conserved in bacteria
DXY22_RS10185	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS10185	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS10205	COG0306	phosphate transporter
DXY22_RS10210	COG1392	Phosphate transport regulator
DXY22_RS10215	COG0531	amino acid
DXY22_RS10220	COG0346	lactoylglutathione lyase activity
DXY22_RS10225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DXY22_RS10230	COG0463	Glycosyl transferase, family 2
DXY22_RS10235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_RS10240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_RS10245	COG2362	D-Aminopeptidase
DXY22_RS10250	COG0601	transmembrane transport
DXY22_RS10255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_RS10260	COG0444	Belongs to the ABC transporter superfamily
DXY22_RS10265	COG4166	transmembrane transport
DXY22_RS10270	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY22_RS10275	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_RS10280	COG0791	NLP P60 protein
DXY22_RS10285	COG4608	Belongs to the ABC transporter superfamily
DXY22_RS10290	COG2706	6-phosphogluconolactonase activity
DXY22_RS10295	COG1834	amidinotransferase
DXY22_RS10300	COG1607	acyl-coa hydrolase
DXY22_RS10305	COG1017	nitric oxide dioxygenase activity
DXY22_RS10305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DXY22_RS10315	COG2323	membrane
DXY22_RS10320	COG2318	DinB family
DXY22_RS10325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS10330	COG2076	Multidrug Resistance protein
DXY22_RS10335	COG2076	Multidrug Resistance protein
DXY22_RS10340	COG0788	formyltetrahydrofolate deformylase activity
DXY22_RS10345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY22_RS10350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DXY22_RS10355	COG1764	response to oxidative stress
DXY22_RS10360	COG1846	Transcriptional regulator
DXY22_RS10365	COG1764	response to oxidative stress
DXY22_RS10375	COG0590	tRNA wobble adenosine to inosine editing
DXY22_RS10380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_RS10385	COG1404	Belongs to the peptidase S8 family
DXY22_RS10390	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS10395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY22_RS10400	COG1122	ATPase activity
DXY22_RS10405	COG4721	ABC-type cobalt transport system, permease component
DXY22_RS10415	COG0745	RESPONSE REGULATOR receiver
DXY22_RS10420	COG5002	protein histidine kinase activity
DXY22_RS10420	COG3850	Histidine kinase
DXY22_RS10425	COG3212	peptidase
DXY22_RS10430	COG3212	peptidase
DXY22_RS10440	COG2239	Acts as a magnesium transporter
DXY22_RS10445	COG0789	Transcriptional regulator
DXY22_RS10460	COG1846	Transcriptional regulator
DXY22_RS10465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_RS10470	COG0726	polysaccharide deacetylase
DXY22_RS10475	COG1408	metallophosphoesterase
DXY22_RS10485	COG0463	Glycosyl transferase, family 2
DXY22_RS10490	COG3285	dna ligase
DXY22_RS10490	COG1793	dna ligase
DXY22_RS10495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DXY22_RS10500	COG3300	MHYT domain
DXY22_RS10500	COG5001	Diguanylate cyclase
DXY22_RS10505	COG0586	Pfam SNARE associated Golgi protein
DXY22_RS10510	COG0861	Integral membrane protein TerC family
DXY22_RS10515	COG1191	sigma factor activity
DXY22_RS10535	COG0501	Belongs to the peptidase M48B family
DXY22_RS10540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DXY22_RS10555	COG3594	Acyltransferase
DXY22_RS10560	COG5002	protein histidine kinase activity
DXY22_RS10565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY22_RS10575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DXY22_RS10580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DXY22_RS10585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY22_RS10590	COG0436	Aminotransferase
DXY22_RS10595	COG1850	ribulose-bisphosphate carboxylase activity
DXY22_RS10600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DXY22_RS10605	COG0235	Class ii aldolase
DXY22_RS10610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DXY22_RS10615	COG3339	Conserved Protein
DXY22_RS10630	COG3852	Histidine kinase
DXY22_RS10635	COG1846	Transcriptional regulator
DXY22_RS10640	COG1360	Flagellar Motor Protein
DXY22_RS10645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY22_RS10650	COG0542	response to heat
DXY22_RS10655	COG3949	Membrane
DXY22_RS10660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DXY22_RS10665	COG0720	synthase
DXY22_RS10670	COG0602	queuosine metabolic process
DXY22_RS10675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DXY22_RS10680	COG1733	regulation of RNA biosynthetic process
DXY22_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS10690	COG4641	Protein conserved in bacteria
DXY22_RS10690	COG1388	LysM domain
DXY22_RS10695	COG1388	LysM domain
DXY22_RS10700	COG3858	chitin binding
DXY22_RS10710	COG4873	Protein conserved in bacteria
DXY22_RS10720	COG3773	Cell wall hydrolase
DXY22_RS10725	COG2244	polysaccharide biosynthetic process
DXY22_RS10730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS10735	COG2217	Heavy metal translocating P-type atpase
DXY22_RS10745	COG0006	proline dipeptidase activity
DXY22_RS10750	COG1609	Transcriptional regulator
DXY22_RS10755	COG3711	transcriptional antiterminator
DXY22_RS10760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS10760	COG1263	PTS System
DXY22_RS10760	COG2190	(PTS) system
DXY22_RS10765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS10770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DXY22_RS10780	COG1533	DNA photolyase activity
DXY22_RS10785	COG0456	acetyltransferase
DXY22_RS10790	COG0840	transmembrane signaling receptor activity
DXY22_RS10795	COG2084	Dehydrogenase
DXY22_RS10800	COG2340	Cysteine-rich secretory protein family
DXY22_RS10805	COG0768	penicillin binding
DXY22_RS10810	COG4191	Histidine kinase
DXY22_RS10815	COG0436	Aminotransferase
DXY22_RS10825	COG0835	chemotaxis
DXY22_RS10825	COG0784	Response regulator, receiver
DXY22_RS10835	COG2814	Major facilitator Superfamily
DXY22_RS10840	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_RS10845	COG1408	metallophosphoesterase
DXY22_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS10855	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS10865	COG2200	EAL domain
DXY22_RS10875	COG4703	Protein of unknown function (DUF1797)
DXY22_RS10880	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DXY22_RS10890	COG0517	IMP dehydrogenase activity
DXY22_RS10895	COG0583	DNA-binding transcription factor activity
DXY22_RS10900	COG0716	FMN binding
DXY22_RS10910	COG0716	FMN binding
DXY22_RS10915	COG2171	N-acyltransferase activity
DXY22_RS10920	COG1473	amidohydrolase
DXY22_RS10930	COG0668	transmembrane transport
DXY22_RS10935	COG0450	alkyl hydroperoxide reductase
DXY22_RS10940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS10955	COG0746	molybdenum cofactor guanylyltransferase activity
DXY22_RS10960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY22_RS10965	COG0303	'Molybdopterin
DXY22_RS10970	COG1763	Mo-molybdopterin cofactor biosynthetic process
DXY22_RS10975	COG0314	molybdopterin synthase activity
DXY22_RS10980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DXY22_RS10985	COG1132	(ABC) transporter
DXY22_RS10990	COG1132	(ABC) transporter
DXY22_RS11000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DXY22_RS11005	COG1136	(ABC) transporter
DXY22_RS11010	COG0577	efflux transmembrane transporter activity
DXY22_RS11015	COG1349	DNA-binding transcription factor activity
DXY22_RS11020	COG1105	Belongs to the carbohydrate kinase PfkB family
DXY22_RS11025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_RS11025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_RS11025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS11030	COG0681	Belongs to the peptidase S26 family
DXY22_RS11040	COG0488	(ABC) transporter
DXY22_RS11045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY22_RS11050	COG2309	aminopeptidase activity
DXY22_RS11060	COG1077	Cell shape determining protein MreB Mrl
DXY22_RS11065	COG2002	toxin-antitoxin pair type II binding
DXY22_RS11070	COG3852	Histidine kinase
DXY22_RS11075	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DXY22_RS11075	COG2105	PFAM AIG2 family protein
DXY22_RS11080	COG0569	domain protein
DXY22_RS11085	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DXY22_RS11090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY22_RS11100	COG0561	phosphatase activity
DXY22_RS11105	COG0242	peptide deformylase activity
DXY22_RS11115	COG0497	DNA recombination
DXY22_RS11120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_RS11125	COG0022	dehydrogenase e1 component
DXY22_RS11130	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_RS11135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_RS11140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS11150	COG1982	Orn Lys Arg decarboxylase major
DXY22_RS11155	COG4476	Belongs to the UPF0223 family
DXY22_RS11160	COG4493	Belongs to the UPF0637 family
DXY22_RS11170	COG0483	inositol monophosphate 1-phosphatase activity
DXY22_RS11180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DXY22_RS11200	COG1595	DNA-templated transcription, initiation
DXY22_RS11230	COG4896	Protein conserved in bacteria
DXY22_RS11240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DXY22_RS11245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY22_RS11250	COG2066	Belongs to the glutaminase family
DXY22_RS11255	COG4838	Belongs to the UPF0358 family
DXY22_RS11260	COG0772	Belongs to the SEDS family
DXY22_RS11265	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DXY22_RS11270	COG1612	heme a metabolic process
DXY22_RS11275	COG0109	protoheme IX farnesyltransferase activity
DXY22_RS11280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY22_RS11280	COG2010	Cytochrome c
DXY22_RS11285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY22_RS11290	COG1845	cytochrome c oxidase, subunit III
DXY22_RS11295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DXY22_RS11300	COG3336	cytochrome c oxidase
DXY22_RS11310	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DXY22_RS11315	COG2340	Cysteine-rich secretory protein family
DXY22_RS11330	COG3679	Belongs to the UPF0342 family
DXY22_RS11335	COG4471	UPF0298 protein
DXY22_RS11340	COG0742	ribosomal rna small subunit methyltransferase
DXY22_RS11345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DXY22_RS11350	COG3314	Sporulation integral membrane protein YlbJ
DXY22_RS11355	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY22_RS11360	COG3480	Lon protease (S16) C-terminal proteolytic domain
DXY22_RS11365	COG1323	Belongs to the UPF0348 family
DXY22_RS11375	COG1399	metal-binding, possibly nucleic acid-binding protein
DXY22_RS11380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DXY22_RS11390	COG0454	-acetyltransferase
DXY22_RS11395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY22_RS11400	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DXY22_RS11405	COG2001	Belongs to the MraZ family
DXY22_RS11410	COG0275	rRNA processing
DXY22_RS11415	COG4839	cell division protein FtsL
DXY22_RS11425	COG0768	penicillin binding
DXY22_RS11430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DXY22_RS11435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DXY22_RS11440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DXY22_RS11445	COG0772	Belongs to the SEDS family
DXY22_RS11450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_RS11455	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DXY22_RS11460	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DXY22_RS11465	COG3879	Bacterial protein of unknown function (DUF881)
DXY22_RS11470	COG3879	Bacterial protein of unknown function (DUF881)
DXY22_RS11475	COG3856	small basic protein
DXY22_RS11480	COG0849	cell division
DXY22_RS11485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DXY22_RS11490	COG4412	M6 family metalloprotease domain protein
DXY22_RS11490	COG1404	Belongs to the peptidase S8 family
DXY22_RS11500	COG1191	sigma factor activity
DXY22_RS11505	COG1191	sigma factor activity
DXY22_RS11510	COG1119	ATPase activity
DXY22_RS11515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_RS11520	COG1873	PFAM PRC-barrel domain
DXY22_RS11530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DXY22_RS11535	COG1799	cell septum assembly
DXY22_RS11540	COG0762	integral membrane protein
DXY22_RS11545	COG2302	S4 RNA-binding domain
DXY22_RS11550	COG3599	regulation of cell shape
DXY22_RS11555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DXY22_RS11560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_RS11565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DXY22_RS11570	COG0564	pseudouridine synthase activity
DXY22_RS11575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DXY22_RS11580	COG2233	PERMEase
DXY22_RS11585	COG0540	Belongs to the ATCase OTCase family
DXY22_RS11590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DXY22_RS11595	COG0505	Belongs to the CarA family
DXY22_RS11600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY22_RS11605	COG0543	2 iron, 2 sulfur cluster binding
DXY22_RS11610	COG0167	dihydroorotate dehydrogenase activity
DXY22_RS11615	COG0284	orotidine-5'-phosphate decarboxylase activity
DXY22_RS11620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DXY22_RS11625	COG0175	sulfate reduction
DXY22_RS11630	COG0306	phosphate transporter
DXY22_RS11635	COG2046	Belongs to the sulfate adenylyltransferase family
DXY22_RS11640	COG0529	Catalyzes the synthesis of activated sulfate
DXY22_RS11645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY22_RS11650	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DXY22_RS11655	COG1648	precorrin-2 dehydrogenase activity
DXY22_RS11665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DXY22_RS11670	COG1561	YicC-like family, N-terminal region
DXY22_RS11675	COG2052	Domain of unknown function (DUF370)
DXY22_RS11680	COG0194	GDP metabolic process
DXY22_RS11685	COG1758	RNA polymerase activity
DXY22_RS11690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY22_RS11695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY22_RS11700	COG0242	peptide deformylase activity
DXY22_RS11705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DXY22_RS11710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DXY22_RS11710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DXY22_RS11715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DXY22_RS11720	COG0631	protein serine/threonine phosphatase activity
DXY22_RS11725	COG2815	serine threonine protein kinase
DXY22_RS11725	COG0515	serine threonine protein kinase
DXY22_RS11730	COG1162	GTPase activity
DXY22_RS11735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DXY22_RS11740	COG1564	THIamine pyrophosphokinase
DXY22_RS11750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DXY22_RS11755	COG1302	Protein conserved in bacteria
DXY22_RS11760	COG1461	Dihydroxyacetone kinase
DXY22_RS11765	COG1760	l-serine dehydratase
DXY22_RS11770	COG1760	l-serine dehydratase
DXY22_RS11775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DXY22_RS11780	COG2050	protein possibly involved in aromatic compounds catabolism
DXY22_RS11780	COG1349	DNA-binding transcription factor activity
DXY22_RS11785	COG0416	fatty acid biosynthetic process
DXY22_RS11790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_RS11795	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS11800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS11805	COG0571	ribonuclease III activity
DXY22_RS11810	COG1196	nuclear chromosome segregation
DXY22_RS11815	COG0552	protein localization to endoplasmic reticulum
DXY22_RS11825	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DXY22_RS11830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DXY22_RS11835	COG0228	four-way junction DNA binding
DXY22_RS11840	COG1837	Belongs to the UPF0109 family
DXY22_RS11850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DXY22_RS11855	COG0336	Belongs to the RNA methyltransferase TrmD family
DXY22_RS11860	COG0335	large ribosomal subunit rRNA binding
DXY22_RS11865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY22_RS11870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DXY22_RS11880	COG2257	FlhB HrpN YscU SpaS Family
DXY22_RS11885	COG0045	succinate-CoA ligase (ADP-forming) activity
DXY22_RS11890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DXY22_RS11895	COG0758	DNA mediated transformation
DXY22_RS11900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY22_RS11905	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DXY22_RS11910	COG4974	Belongs to the 'phage' integrase family
DXY22_RS11915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DXY22_RS11920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DXY22_RS11925	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DXY22_RS11930	COG1815	bacterial-type flagellum-dependent cell motility
DXY22_RS11935	COG1558	bacterial-type flagellum-dependent cell motility
DXY22_RS11940	COG1677	Flagellar hook-basal body complex protein FliE
DXY22_RS11945	COG1766	The M ring may be actively involved in energy transduction
DXY22_RS11950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_RS11955	COG1317	bacterial-type flagellum organization
DXY22_RS11960	COG1157	protein secretion by the type III secretion system
DXY22_RS11965	COG2882	bacterial-type flagellum organization
DXY22_RS11970	COG3334	PFAM MgtE intracellular
DXY22_RS11975	COG3144	bacterial-type flagellum assembly
DXY22_RS11980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DXY22_RS11985	COG4786	Flagellar basal body rod
DXY22_RS11990	COG1582	Flagellar protein (FlbD)
DXY22_RS11995	COG1580	Controls the rotational direction of flagella during chemotaxis
DXY22_RS12000	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_RS12005	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_RS12005	COG1776	CheC inhibitor of MCP methylation
DXY22_RS12010	COG2201	protein-glutamate methylesterase activity
DXY22_RS12015	COG3190	flagellar
DXY22_RS12020	COG1338	Plays a role in the flagellum-specific transport system
DXY22_RS12025	COG1987	bacterial-type flagellum assembly
DXY22_RS12030	COG1684	flagellar biosynthetic protein fliR
DXY22_RS12035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY22_RS12040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY22_RS12045	COG1419	protein localization to endoplasmic reticulum
DXY22_RS12050	COG0455	bacterial-type flagellum organization
DXY22_RS12055	COG2201	protein-glutamate methylesterase activity
DXY22_RS12060	COG0643	Histidine kinase
DXY22_RS12060	COG2198	Histidine kinase
DXY22_RS12065	COG0835	chemotaxis
DXY22_RS12070	COG1776	CheC inhibitor of MCP methylation
DXY22_RS12075	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DXY22_RS12080	COG1191	sigma factor activity
DXY22_RS12090	COG0052	Belongs to the universal ribosomal protein uS2 family
DXY22_RS12095	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DXY22_RS12100	COG0528	UMP kinase activity
DXY22_RS12105	COG0233	cytoplasmic translational termination
DXY22_RS12110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DXY22_RS12115	COG4589	Belongs to the CDS family
DXY22_RS12120	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DXY22_RS12125	COG0750	zinc metalloprotease
DXY22_RS12130	COG0442	prolyl-tRNA aminoacylation
DXY22_RS12135	COG2176	DNA-directed DNA polymerase activity
DXY22_RS12140	COG0779	Required for maturation of 30S ribosomal subunits
DXY22_RS12145	COG0195	Participates in both transcription termination and antitermination
DXY22_RS12150	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DXY22_RS12155	COG1358	cellular component organization or biogenesis
DXY22_RS12160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DXY22_RS12165	COG1550	Protein conserved in bacteria
DXY22_RS12170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DXY22_RS12175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DXY22_RS12180	COG0196	riboflavin kinase activity
DXY22_RS12185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DXY22_RS12190	COG1185	polyribonucleotide nucleotidyltransferase activity
DXY22_RS12195	COG0726	polysaccharide deacetylase
DXY22_RS12200	COG0612	Peptidase, M16
DXY22_RS12205	COG1873	PFAM PRC-barrel domain
DXY22_RS12210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY22_RS12215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY22_RS12220	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DXY22_RS12225	COG0527	aspartate kinase activity
DXY22_RS12230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DXY22_RS12235	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY22_RS12240	COG0740	serine-type endopeptidase activity
DXY22_RS12250	COG1674	ftsk spoiiie
DXY22_RS12250	COG4980	gas vesicle protein
DXY22_RS12255	COG2188	Transcriptional regulator
DXY22_RS12260	COG2814	Major facilitator Superfamily
DXY22_RS12265	COG0612	Peptidase, M16
DXY22_RS12270	COG0612	Peptidase, M16
DXY22_RS12275	COG0300	oxidoreductase activity
DXY22_RS12290	COG1426	Protein conserved in bacteria
DXY22_RS12295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DXY22_RS12300	COG1058	Belongs to the CinA family
DXY22_RS12300	COG1546	Belongs to the CinA family
DXY22_RS12305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DXY22_RS12310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_RS12315	COG1418	mRNA catabolic process
DXY22_RS12320	COG1692	metallophosphoesterase
DXY22_RS12325	COG2359	stage V sporulation protein S
DXY22_RS12330	COG1063	alcohol dehydrogenase
DXY22_RS12335	COG0156	8-amino-7-oxononanoate synthase activity
DXY22_RS12340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DXY22_RS12345	COG4550	Control of competence regulator ComK, YlbF/YmcA
DXY22_RS12355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DXY22_RS12360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DXY22_RS12375	COG3226	Transcriptional regulator
DXY22_RS12380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS12390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_RS12395	COG3321	synthase
DXY22_RS12400	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_RS12400	COG2070	2-Nitropropane dioxygenase
DXY22_RS12405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS12410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY22_RS12415	COG3425	synthase
DXY22_RS12420	COG1024	Enoyl-CoA hydratase
DXY22_RS12425	COG1024	Enoyl-CoA hydratase
DXY22_RS12430	COG3321	synthase
DXY22_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS12430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS12430	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS12430	COG0300	oxidoreductase activity
DXY22_RS12435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS12435	COG0300	oxidoreductase activity
DXY22_RS12435	COG3321	synthase
DXY22_RS12435	COG4221	oxidoreductase activity
DXY22_RS12440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_RS12440	COG3321	synthase
DXY22_RS12440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS12440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS12445	COG3321	synthase
DXY22_RS12445	COG4221	oxidoreductase activity
DXY22_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS12445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS12450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY22_RS12450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DXY22_RS12450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_RS12450	COG3321	synthase
DXY22_RS12455	COG2124	cytochrome p450
DXY22_RS12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS12470	COG1404	Belongs to the peptidase S8 family
DXY22_RS12480	COG4195	phage-related replication protein
DXY22_RS12485	COG1764	response to oxidative stress
DXY22_RS12490	COG2076	Multidrug Resistance protein
DXY22_RS12495	COG2076	Multidrug Resistance protein
DXY22_RS12510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DXY22_RS12515	COG1923	regulation of RNA biosynthetic process
DXY22_RS12530	COG1780	Probably involved in ribonucleotide reductase function
DXY22_RS12535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY22_RS12540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY22_RS12545	COG4112	unkown
DXY22_RS12550	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS12555	COG0464	growth
DXY22_RS12560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DXY22_RS12565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DXY22_RS12570	COG0789	Transcriptional regulator
DXY22_RS12575	COG0174	glutamine synthetase
DXY22_RS12595	COG4282	regulation of fungal-type cell wall biogenesis
DXY22_RS12605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS12620	COG3655	Transcriptional regulator
DXY22_RS12635	COG0135	phosphoribosylanthranilate isomerase activity
DXY22_RS12640	COG2211	Major facilitator Superfamily
DXY22_RS12645	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_RS12650	COG1940	carbohydrate kinase activity
DXY22_RS12655	COG2115	Belongs to the xylose isomerase family
DXY22_RS12660	COG1070	Carbohydrate kinase
DXY22_RS12670	COG1525	nuclease
DXY22_RS12675	COG2814	Major facilitator Superfamily
DXY22_RS12680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY22_RS12690	COG0756	dUTP diphosphatase activity
DXY22_RS12730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_RS12745	COG3832	glyoxalase III activity
DXY22_RS12755	COG0697	spore germination
DXY22_RS12760	COG0531	amino acid
DXY22_RS12790	COG4195	phage-related replication protein
DXY22_RS12800	COG0346	lactoylglutathione lyase activity
DXY22_RS12805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DXY22_RS12810	COG1388	LysM domain
DXY22_RS12815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_RS12820	COG4224	UPF0291 protein
DXY22_RS12825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DXY22_RS12835	COG3763	UPF0154 protein
DXY22_RS12845	COG0785	Cytochrome C biogenesis protein
DXY22_RS12850	COG2201	protein-glutamate methylesterase activity
DXY22_RS12855	COG4846	Membrane protein involved in cytochrome C biogenesis
DXY22_RS12865	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_RS12880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DXY22_RS12885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS12905	COG0824	Thioesterase
DXY22_RS12915	COG4841	protein insertion into membrane
DXY22_RS12920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DXY22_RS12925	COG1832	CoA-binding protein
DXY22_RS12930	COG0187	DNA topoisomerase II activity
DXY22_RS12935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY22_RS12945	COG1115	amino acid carrier protein
DXY22_RS12950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DXY22_RS12960	COG5520	Belongs to the glycosyl hydrolase 30 family
DXY22_RS12965	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_RS12970	COG2246	polysaccharide biosynthetic process
DXY22_RS12975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_RS12980	COG0586	Pfam SNARE associated Golgi protein
DXY22_RS12985	COG2404	hydrolase activity, acting on ester bonds
DXY22_RS12990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY22_RS12995	COG1024	Enoyl-CoA hydratase
DXY22_RS13000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DXY22_RS13005	COG0511	ligase activity, forming carbon-carbon bonds
DXY22_RS13010	COG0439	Biotin carboxylase
DXY22_RS13015	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS13020	COG1960	acyl-CoA dehydrogenase activity
DXY22_RS13035	COG1649	PFAM Uncharacterised BCR, COG1649
DXY22_RS13045	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY22_RS13045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS13050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS13055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS13060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS13065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS13070	COG2027	D-alanyl-D-alanine carboxypeptidase
DXY22_RS13075	COG2017	converts alpha-aldose to the beta-anomer
DXY22_RS13080	COG0534	Mate efflux family protein
DXY22_RS13095	COG0582	viral genome integration into host DNA
DXY22_RS13100	COG0166	Belongs to the GPI family
DXY22_RS13105	COG0405	Gamma-glutamyltransferase
DXY22_RS13110	COG0583	DNA-binding transcription factor activity
DXY22_RS13115	COG0604	alcohol dehydrogenase
DXY22_RS13120	COG0493	'glutamate synthase
DXY22_RS13125	COG0069	glutamate synthase activity
DXY22_RS13125	COG0067	glutamate synthase
DXY22_RS13125	COG0070	glutamate synthase
DXY22_RS13130	COG0583	DNA-binding transcription factor activity
DXY22_RS13135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY22_RS13140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_RS13150	COG0300	oxidoreductase activity
DXY22_RS13155	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY22_RS13165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_RS13180	COG1131	(ABC) transporter
DXY22_RS13190	COG2814	Major facilitator Superfamily
DXY22_RS13195	COG1070	Carbohydrate kinase
DXY22_RS13200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY22_RS13205	COG0243	molybdopterin cofactor binding
DXY22_RS13235	COG5278	phosphoserine phosphatase activity
DXY22_RS13235	COG0840	transmembrane signaling receptor activity
DXY22_RS13240	COG2368	4-hydroxyphenylacetate
DXY22_RS13245	COG4305	rare lipoprotein A
DXY22_RS13250	COG3619	membrane
DXY22_RS13255	COG3866	Pectate lyase
DXY22_RS13260	COG2135	peptidase activity
DXY22_RS13270	COG2140	Oxalate decarboxylase
DXY22_RS13285	COG0456	acetyltransferase
DXY22_RS13305	COG2720	vancomycin resistance protein
DXY22_RS13315	COG3655	Transcriptional regulator
DXY22_RS13320	COG3739	integral membrane protein
DXY22_RS13325	COG0583	DNA-binding transcription factor activity
DXY22_RS13330	COG0697	spore germination
DXY22_RS13340	COG0693	protein deglycase activity
DXY22_RS13345	COG2367	Beta-lactamase
DXY22_RS13365	COG0574	Belongs to the PEP-utilizing enzyme family
DXY22_RS13365	COG3848	Pyruvate phosphate dikinase
DXY22_RS13370	COG0726	polysaccharide deacetylase
DXY22_RS13375	COG2314	TM2 domain
DXY22_RS13380	COG1396	sequence-specific DNA binding
DXY22_RS13420	COG2723	6-phospho-beta-galactosidase activity
DXY22_RS13435	COG0395	ABC-type sugar transport system, permease component
DXY22_RS13440	COG1175	transmembrane transport
DXY22_RS13450	COG1940	carbohydrate kinase activity
DXY22_RS13465	COG5444	nuclease activity
DXY22_RS13470	COG4282	regulation of fungal-type cell wall biogenesis
DXY22_RS13475	COG1231	oxidoreductase activity
DXY22_RS13480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_RS13485	COG2207	Transcriptional regulator
DXY22_RS13485	COG0662	Cupin 2, conserved barrel domain protein
DXY22_RS13490	COG0456	acetyltransferase
DXY22_RS13495	COG1309	transcriptional regulator
DXY22_RS13500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS13505	COG3708	Transcriptional regulator
DXY22_RS13510	COG2378	regulation of single-species biofilm formation
DXY22_RS13520	COG0640	Transcriptional regulator
DXY22_RS13525	COG0741	lytic transglycosylase activity
DXY22_RS13530	COG2322	membrane
DXY22_RS13545	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY22_RS13550	COG3239	Fatty acid desaturase
DXY22_RS13555	COG4585	Histidine kinase
DXY22_RS13560	COG2197	response regulator
DXY22_RS13565	COG1388	LysM domain
DXY22_RS13565	COG3584	3D domain protein
DXY22_RS13570	COG0514	ATP-dependent DNA helicase (RecQ)
DXY22_RS13580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DXY22_RS13585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_RS13600	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_RS13625	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_RS13630	COG1657	PFAM Prenyltransferase squalene oxidase
DXY22_RS13635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY22_RS13640	COG0733	neurotransmitter:sodium symporter activity
DXY22_RS13645	COG0385	Bile acid
DXY22_RS13650	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_RS13655	COG0567	Dehydrogenase, E1 component
DXY22_RS13660	COG4548	von Willebrand factor, type A
DXY22_RS13665	COG0714	Associated with various cellular activities
DXY22_RS13670	COG2032	superoxide dismutase activity
DXY22_RS13675	COG1388	LysM domain
DXY22_RS13675	COG0791	NLP P60 protein
DXY22_RS13680	COG1819	glycosyl
DXY22_RS13685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY22_RS13690	COG0534	Mate efflux family protein
DXY22_RS13695	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS13700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_RS13705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_RS13715	COG2962	Rard protein
DXY22_RS13730	COG2610	gluconate transmembrane transporter activity
DXY22_RS13735	COG1942	4-Oxalocrotonate Tautomerase
DXY22_RS13740	COG1733	regulation of RNA biosynthetic process
DXY22_RS13745	COG0778	Nitroreductase
DXY22_RS13750	COG0400	carboxylic ester hydrolase activity
DXY22_RS13755	COG0346	lactoylglutathione lyase activity
DXY22_RS13765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_RS13770	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS13770	COG0793	Belongs to the peptidase S41A family
DXY22_RS13775	COG2226	methyltransferase
DXY22_RS13785	COG1876	peptidase activity
DXY22_RS13790	COG0813	purine-nucleoside phosphorylase activity
DXY22_RS13805	COG0671	phosphoesterase, PA-phosphatase related
DXY22_RS13825	COG4479	Belongs to the UPF0346 family
DXY22_RS13835	COG1509	lysine 2,3-aminomutase activity
DXY22_RS13840	COG0456	acetyltransferase
DXY22_RS13845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_RS13850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY22_RS13855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY22_RS13860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_RS13875	COG0456	acetyltransferase
DXY22_RS13880	COG0463	Glycosyl transferase, family 2
DXY22_RS13895	COG4641	Protein conserved in bacteria
DXY22_RS13900	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DXY22_RS13905	COG1086	Polysaccharide biosynthesis protein
DXY22_RS13910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DXY22_RS13915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DXY22_RS13920	COG1846	Transcriptional regulator
DXY22_RS13925	COG0534	Mate efflux family protein
DXY22_RS13935	COG4698	Protein conserved in bacteria
DXY22_RS13940	COG2755	lipolytic protein G-D-S-L family
DXY22_RS13945	COG1999	signal sequence binding
DXY22_RS13955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DXY22_RS13960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DXY22_RS13965	COG1272	protein, Hemolysin III
DXY22_RS13970	COG0204	Acyl-transferase
DXY22_RS13975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_RS13980	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DXY22_RS13985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DXY22_RS13995	COG2136	Putative SAM-dependent methyltransferase
DXY22_RS13995	COG2521	methyltransferase
DXY22_RS14005	COG0129	dihydroxy-acid dehydratase activity
DXY22_RS14010	COG1413	lyase activity
DXY22_RS14015	COG1418	mRNA catabolic process
DXY22_RS14020	COG0386	Belongs to the glutathione peroxidase family
DXY22_RS14025	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DXY22_RS14030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_RS14040	COG1278	Cold shock
DXY22_RS14060	COG0328	RNA-DNA hybrid ribonuclease activity
DXY22_RS14065	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DXY22_RS14070	COG0328	RNA-DNA hybrid ribonuclease activity
DXY22_RS14080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_RS14095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY22_RS14105	COG1755	Isoprenylcysteine carboxyl methyltransferase
DXY22_RS14110	COG3424	synthase
DXY22_RS14115	COG2233	PERMEase
DXY22_RS14120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_RS14125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DXY22_RS14135	COG0800	Aldolase
DXY22_RS14140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_RS14145	COG1609	Transcriptional regulator
DXY22_RS14150	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DXY22_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS14160	COG1199	ATP-dependent helicase activity
DXY22_RS14180	COG0116	Belongs to the methyltransferase superfamily
DXY22_RS14195	COG4474	Belongs to the UPF0398 family
DXY22_RS14210	COG3359	exonuclease
DXY22_RS14215	COG1205	dead DEAH box helicase
DXY22_RS14215	COG1111	helicase
DXY22_RS14220	COG2190	(PTS) system
DXY22_RS14225	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_RS14260	COG3331	DNA recombination
DXY22_RS14265	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY22_RS14265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_RS14275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DXY22_RS14280	COG3935	DnaD domain protein
DXY22_RS14285	COG0017	Asparaginyl-tRNA synthetase
DXY22_RS14290	COG0436	Aminotransferase
DXY22_RS14295	COG5353	protein conserved in bacteria
DXY22_RS14305	COG1199	ATP-dependent helicase activity
DXY22_RS14305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DXY22_RS14310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DXY22_RS14315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DXY22_RS14320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DXY22_RS14325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DXY22_RS14325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DXY22_RS14330	COG0617	tRNA 3'-terminal CCA addition
DXY22_RS14335	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS14340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_RS14345	COG1803	Methylglyoxal synthase
DXY22_RS14350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DXY22_RS14355	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY22_RS14360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS14370	COG4347	Protein of unknown function (DUF1405)
DXY22_RS14375	COG2010	Cytochrome c
DXY22_RS14375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY22_RS14380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY22_RS14385	COG0723	plastoquinol--plastocyanin reductase activity
DXY22_RS14395	COG5582	Belongs to the UPF0302 family
DXY22_RS14400	COG0457	Tetratricopeptide repeat
DXY22_RS14405	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DXY22_RS14410	COG0287	Prephenate dehydrogenase
DXY22_RS14415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DXY22_RS14420	COG0159	tryptophan synthase activity
DXY22_RS14425	COG0133	tryptophan synthase activity
DXY22_RS14430	COG0135	phosphoribosylanthranilate isomerase activity
DXY22_RS14440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DXY22_RS14445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY22_RS14450	COG4401	Chorismate mutase type I
DXY22_RS14455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DXY22_RS14460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DXY22_RS14465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DXY22_RS14470	COG0105	UTP biosynthetic process
DXY22_RS14475	COG0142	geranyltranstransferase activity
DXY22_RS14480	COG2226	methyltransferase
DXY22_RS14485	COG0142	geranyltranstransferase activity
DXY22_RS14495	COG0302	gtp cyclohydrolase
DXY22_RS14500	COG0776	regulation of translation
DXY22_RS14505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY22_RS14520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DXY22_RS14525	COG1160	GTP binding
DXY22_RS14550	COG1304	FMN binding
DXY22_RS14555	COG0539	negative regulation of cytoplasmic translation
DXY22_RS14560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DXY22_RS14570	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DXY22_RS14575	COG2959	enzyme of heme biosynthesis
DXY22_RS14580	COG3773	Cell wall hydrolase
DXY22_RS14580	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS14585	COG2339	peptidase activity
DXY22_RS14590	COG0492	ferredoxin-NADP+ reductase activity
DXY22_RS14595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_RS14600	COG4862	establishment of competence for transformation
DXY22_RS14605	COG1408	metallophosphoesterase
DXY22_RS14615	COG1388	LysM domain
DXY22_RS14620	COG1266	CAAX protease self-immunity
DXY22_RS14625	COG0514	ATP-dependent DNA helicase (RecQ)
DXY22_RS14630	COG4955	Helix-turn-helix domain
DXY22_RS14635	COG1141	Ferredoxin
DXY22_RS14640	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DXY22_RS14645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY22_RS14650	COG0710	3-dehydroquinate dehydratase activity
DXY22_RS14660	COG1595	DNA-templated transcription, initiation
DXY22_RS14665	COG5002	protein histidine kinase activity
DXY22_RS14670	COG0745	RESPONSE REGULATOR receiver
DXY22_RS14675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY22_RS14680	COG1333	cytochrome c biogenesis protein
DXY22_RS14685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS14690	COG1187	pseudouridine synthase activity
DXY22_RS14695	COG0700	Nucleoside recognition
DXY22_RS14700	COG2715	membrane protein required for spore maturation
DXY22_RS14705	COG1686	Belongs to the peptidase S11 family
DXY22_RS14715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DXY22_RS14720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DXY22_RS14725	COG1547	Domain of unknown function (DUF309)
DXY22_RS14730	COG0456	acetyltransferase
DXY22_RS14735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DXY22_RS14740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DXY22_RS14740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DXY22_RS14745	COG0307	riboflavin synthase, alpha
DXY22_RS14750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY22_RS14750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY22_RS14760	COG0681	Belongs to the peptidase S26 family
DXY22_RS14770	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DXY22_RS14795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DXY22_RS14800	COG4086	secreted protein
DXY22_RS14805	COG0019	diaminopimelate decarboxylase activity
DXY22_RS14810	COG0697	spore germination
DXY22_RS14825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_RS14845	COG1191	sigma factor activity
DXY22_RS14850	COG2172	sigma factor antagonist activity
DXY22_RS14855	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS14860	COG1686	Belongs to the peptidase S11 family
DXY22_RS14865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DXY22_RS14870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DXY22_RS14875	COG4974	Belongs to the 'phage' integrase family
DXY22_RS14885	COG0735	belongs to the Fur family
DXY22_RS14890	COG1300	Membrane
DXY22_RS14900	COG0281	malic enzyme
DXY22_RS14905	COG1757	Na H antiporter
DXY22_RS14910	COG1027	Aspartate ammonia-lyase
DXY22_RS14915	COG0252	asparaginase activity
DXY22_RS14920	COG1396	sequence-specific DNA binding
DXY22_RS14925	COG1379	DNA repair
DXY22_RS14930	COG0494	nUDIX hydrolase
DXY22_RS14940	COG0667	Aldo Keto reductase
DXY22_RS14950	COG1073	alpha beta
DXY22_RS14960	COG4918	Iron-sulphur cluster biosynthesis
DXY22_RS14965	COG0456	acetyltransferase
DXY22_RS14965	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DXY22_RS14970	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_RS14975	COG0456	acetyltransferase
DXY22_RS14985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY22_RS14995	COG2211	Major facilitator Superfamily
DXY22_RS15000	COG0346	lactoylglutathione lyase activity
DXY22_RS15005	COG1072	(Pantothenic acid kinase))
DXY22_RS15010	COG3048	D-serine ammonia-lyase activity
DXY22_RS15015	COG0300	oxidoreductase activity
DXY22_RS15020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS15025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_RS15030	COG4187	Peptidase family M20/M25/M40
DXY22_RS15035	COG1902	pentaerythritol trinitrate reductase activity
DXY22_RS15040	COG0596	Alpha beta hydrolase
DXY22_RS15050	COG1234	tRNA 3'-trailer cleavage
DXY22_RS15055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DXY22_RS15060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DXY22_RS15065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY22_RS15075	COG0706	membrane insertase activity
DXY22_RS15080	COG3361	conserved protein (COG2071)
DXY22_RS15085	COG2195	Cleaves the N-terminal amino acid of tripeptides
DXY22_RS15090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY22_RS15095	COG0346	lactoylglutathione lyase activity
DXY22_RS15105	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_RS15110	COG4129	membrane
DXY22_RS15115	COG1126	abc transporter atp-binding protein
DXY22_RS15120	COG0765	amino acid transport
DXY22_RS15125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS15135	COG1597	lipid kinase activity
DXY22_RS15140	COG2814	Major facilitator Superfamily
DXY22_RS15145	COG0789	Transcriptional regulator
DXY22_RS15145	COG4978	Transcriptional regulator
DXY22_RS15150	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_RS15155	COG0022	dehydrogenase e1 component
DXY22_RS15160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_RS15165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_RS15170	COG3426	butyrate kinase activity
DXY22_RS15175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_RS15180	COG0280	phosphate acetyltransferase
DXY22_RS15185	COG3290	protein histidine kinase activity
DXY22_RS15185	COG3829	transcription factor binding
DXY22_RS15195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DXY22_RS15200	COG2079	MmgE PrpD family protein
DXY22_RS15205	COG0372	Belongs to the citrate synthase family
DXY22_RS15210	COG1960	acyl-CoA dehydrogenase activity
DXY22_RS15215	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY22_RS15220	COG0183	Belongs to the thiolase family
DXY22_RS15225	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_RS15230	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS15245	COG1902	pentaerythritol trinitrate reductase activity
DXY22_RS15250	COG0745	RESPONSE REGULATOR receiver
DXY22_RS15255	COG0750	zinc metalloprotease
DXY22_RS15260	COG0497	DNA recombination
DXY22_RS15265	COG1438	arginine binding
DXY22_RS15270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DXY22_RS15275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DXY22_RS15280	COG0142	geranyltranstransferase activity
DXY22_RS15285	COG1722	exodeoxyribonuclease VII activity
DXY22_RS15290	COG1570	exodeoxyribonuclease VII activity
DXY22_RS15295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DXY22_RS15300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DXY22_RS15305	COG1302	Protein conserved in bacteria
DXY22_RS15310	COG0439	Biotin carboxylase
DXY22_RS15315	COG0511	ligase activity, forming carbon-carbon bonds
DXY22_RS15355	COG3854	ATPases associated with a variety of cellular activities
DXY22_RS15365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DXY22_RS15370	COG0006	proline dipeptidase activity
DXY22_RS15375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DXY22_RS15385	COG3872	metal-dependent enzyme
DXY22_RS15395	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY22_RS15400	COG1321	iron dependent repressor
DXY22_RS15405	COG0095	Lipoate-protein ligase
DXY22_RS15410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_RS15415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DXY22_RS15420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DXY22_RS15425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DXY22_RS15430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY22_RS15445	COG1396	sequence-specific DNA binding
DXY22_RS15455	COG0681	Belongs to the peptidase S26 family
DXY22_RS15480	COG4940	Competence protein ComGF
DXY22_RS15490	COG4970	Tfp pilus assembly protein FimT
DXY22_RS15495	COG4537	Required for transformation and DNA binding
DXY22_RS15500	COG1459	type II secretion system
DXY22_RS15505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DXY22_RS15510	COG0517	IMP dehydrogenase activity
DXY22_RS15515	COG0598	Magnesium transport protein CorA
DXY22_RS15520	COG1253	flavin adenine dinucleotide binding
DXY22_RS15525	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS15535	COG1393	Belongs to the ArsC family
DXY22_RS15545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS15555	COG0011	TIGRFAM Protein of
DXY22_RS15565	COG2866	Carboxypeptidase
DXY22_RS15570	COG1368	sulfuric ester hydrolase activity
DXY22_RS15575	COG1940	carbohydrate kinase activity
DXY22_RS15580	COG4483	Protein conserved in bacteria
DXY22_RS15585	COG0457	Tetratricopeptide repeat
DXY22_RS15585	COG0705	Rhomboid family
DXY22_RS15595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DXY22_RS15600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DXY22_RS15605	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS15620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY22_RS15625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_RS15630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_RS15635	COG0581	inorganic phosphate transmembrane transporter activity
DXY22_RS15640	COG0573	inorganic phosphate transmembrane transporter activity
DXY22_RS15645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DXY22_RS15655	COG0477	Major facilitator Superfamily
DXY22_RS15660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY22_RS15665	COG2839	Protein conserved in bacteria
DXY22_RS15670	COG5521	maltodextrose utilization protein MalA
DXY22_RS15680	COG1388	LysM domain
DXY22_RS15685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DXY22_RS15690	COG4709	membrane
DXY22_RS15695	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DXY22_RS15700	COG0735	belongs to the Fur family
DXY22_RS15705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_RS15715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DXY22_RS15720	COG0513	Belongs to the DEAD box helicase family
DXY22_RS15730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DXY22_RS15735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DXY22_RS15740	COG2384	SAM-dependent methyltransferase
DXY22_RS15745	COG2010	Cytochrome c
DXY22_RS15750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DXY22_RS15755	COG0358	DNA primase activity
DXY22_RS15760	COG1671	Belongs to the UPF0178 family
DXY22_RS15765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DXY22_RS15770	COG0517	IMP dehydrogenase activity
DXY22_RS15775	COG0751	glycine-tRNA ligase activity
DXY22_RS15780	COG0752	glycyl-tRNA synthetase alpha subunit
DXY22_RS15785	COG1381	Involved in DNA repair and RecF pathway recombination
DXY22_RS15795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DXY22_RS15800	COG0295	cytidine deaminase activity
DXY22_RS15805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DXY22_RS15810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DXY22_RS15815	COG1480	7TM receptor with intracellular HD hydrolase
DXY22_RS15820	COG1702	phosphate starvation-inducible protein PhoH
DXY22_RS15825	COG0561	phosphatase activity
DXY22_RS15840	COG4864	UPF0365 protein
DXY22_RS15845	COG1030	water channel activity
DXY22_RS15850	COG1610	YqeY-like protein
DXY22_RS15855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DXY22_RS15860	COG1283	sodium-dependent phosphate transmembrane transporter activity
DXY22_RS15865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DXY22_RS15870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DXY22_RS15875	COG2264	protein methyltransferase activity
DXY22_RS15880	COG0484	heat shock protein binding
DXY22_RS15885	COG0443	Heat shock 70 kDa protein
DXY22_RS15890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DXY22_RS15895	COG1420	regulation of RNA biosynthetic process
DXY22_RS15900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY22_RS15905	COG0481	GTPase activity
DXY22_RS15915	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS15920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DXY22_RS15925	COG0268	Binds directly to 16S ribosomal RNA
DXY22_RS15930	COG1466	dna polymerase III delta subunit
DXY22_RS15945	COG2333	competence protein COMEC
DXY22_RS15945	COG0658	competence protein
DXY22_RS15950	COG2131	deaminase
DXY22_RS15955	COG1596	polysaccharide export
DXY22_RS15955	COG1555	photosystem II stabilization
DXY22_RS15960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_RS15965	COG2226	methyltransferase
DXY22_RS15970	COG0799	negative regulation of ribosome biogenesis
DXY22_RS15975	COG1713	HD superfamily hydrolase involved in NAD metabolism
DXY22_RS15980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DXY22_RS15985	COG1534	Rna-binding protein
DXY22_RS15990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DXY22_RS15995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY22_RS16000	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DXY22_RS16010	COG2755	lipolytic protein G-D-S-L family
DXY22_RS16015	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS16015	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS16020	COG0398	Pfam SNARE associated Golgi protein
DXY22_RS16025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DXY22_RS16035	COG3209	COG3209 Rhs family protein
DXY22_RS16050	COG0477	Major facilitator Superfamily
DXY22_RS16055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_RS16060	COG4124	Belongs to the glycosyl hydrolase 26 family
DXY22_RS16065	COG0457	Tetratricopeptide repeat
DXY22_RS16085	COG5444	nuclease activity
DXY22_RS16100	COG1309	transcriptional regulator
DXY22_RS16110	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS16110	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS16110	COG1388	LysM domain
DXY22_RS16170	COG0563	adenylate kinase activity
DXY22_RS16175	COG2856	Zn peptidase
DXY22_RS16190	COG0642	Histidine kinase
DXY22_RS16190	COG5002	protein histidine kinase activity
DXY22_RS16195	COG0745	RESPONSE REGULATOR receiver
DXY22_RS16200	COG2311	Membrane
DXY22_RS16210	COG0454	-acetyltransferase
DXY22_RS16215	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_RS16225	COG0730	response to heat
DXY22_RS16230	COG0425	Belongs to the sulfur carrier protein TusA family
DXY22_RS16235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS16235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_RS16245	COG0425	Belongs to the sulfur carrier protein TusA family
DXY22_RS16245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_RS16250	COG2210	Belongs to the sulfur carrier protein TusA family
DXY22_RS16255	COG1937	Protein conserved in bacteria
DXY22_RS16260	COG0662	Cupin 2, conserved barrel domain protein
DXY22_RS16270	COG4978	Transcriptional regulator
DXY22_RS16270	COG0789	Transcriptional regulator
DXY22_RS16275	COG2814	Major facilitator Superfamily
DXY22_RS16280	COG0456	acetyltransferase
DXY22_RS16285	COG1253	flavin adenine dinucleotide binding
DXY22_RS16295	COG0697	spore germination
DXY22_RS16300	COG0583	DNA-binding transcription factor activity
DXY22_RS16305	COG2072	flavoprotein involved in K transport
DXY22_RS16310	COG1230	cation diffusion facilitator family transporter
DXY22_RS16315	COG1942	4-Oxalocrotonate Tautomerase
DXY22_RS16320	COG0583	DNA-binding transcription factor activity
DXY22_RS16330	COG1114	Component of the transport system for branched-chain amino acids
DXY22_RS16335	COG1687	branched-chain amino acid
DXY22_RS16340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DXY22_RS16345	COG1522	sequence-specific DNA binding
DXY22_RS16350	COG2732	(Barnase) inhibitor
DXY22_RS16355	COG2124	cytochrome p450
DXY22_RS16360	COG1335	isochorismatase
DXY22_RS16375	COG2318	DinB family
DXY22_RS16385	COG2070	2-Nitropropane dioxygenase
DXY22_RS16390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DXY22_RS16410	COG3443	Belongs to the bacterial solute-binding protein 9 family
DXY22_RS16415	COG1595	DNA-templated transcription, initiation
DXY22_RS16420	COG0667	Aldo Keto reductase
DXY22_RS16425	COG2851	Citrate transporter
DXY22_RS16430	COG0583	DNA-binding transcription factor activity
DXY22_RS16435	COG2828	Protein conserved in bacteria
DXY22_RS16440	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS16445	COG5566	PFAM Mor transcription activator
DXY22_RS16450	COG0596	Alpha beta hydrolase
DXY22_RS16455	COG4991	sh3 domain protein
DXY22_RS16460	COG4991	sh3 domain protein
DXY22_RS16470	COG0346	lactoylglutathione lyase activity
DXY22_RS16480	COG5577	PFAM Coat F domain
DXY22_RS16485	COG1063	alcohol dehydrogenase
DXY22_RS16495	COG5577	PFAM Coat F domain
DXY22_RS16500	COG0789	Transcriptional regulator
DXY22_RS16510	COG1064	alcohol dehydrogenase
DXY22_RS16515	COG0693	protein deglycase activity
DXY22_RS16520	COG1621	beta-fructofuranosidase activity
DXY22_RS16525	COG3716	PTS system mannose fructose sorbose family IID component
DXY22_RS16530	COG3715	PTS system
DXY22_RS16535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_RS16540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS16545	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DXY22_RS16545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DXY22_RS16555	COG1113	amino acid transport
DXY22_RS16560	COG1280	lysine exporter protein (LysE YggA)
DXY22_RS16565	COG1378	Sugar-specific transcriptional regulator TrmB
DXY22_RS16570	COG1595	DNA-templated transcription, initiation
DXY22_RS16580	COG2755	lipolytic protein G-D-S-L family
DXY22_RS16580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DXY22_RS16590	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_RS16590	COG2124	cytochrome p450
DXY22_RS16595	COG1309	transcriptional regulator
DXY22_RS16600	COG2226	methyltransferase
DXY22_RS16615	COG2116	formate transmembrane transporter activity
DXY22_RS16620	COG5609	conserved protein (DUF2294)
DXY22_RS16625	COG3383	formate dehydrogenase (NAD+) activity
DXY22_RS16630	COG2427	Protein of unknown function (DUF1641)
DXY22_RS16640	COG0626	cystathionine gamma-synthase activity
DXY22_RS16645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_RS16650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DXY22_RS16655	COG2226	methyltransferase
DXY22_RS16670	COG0768	penicillin binding
DXY22_RS16675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DXY22_RS16680	COG0572	uridine kinase
DXY22_RS16700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY22_RS16705	COG3906	Belongs to the UPF0473 family
DXY22_RS16710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DXY22_RS16715	COG4472	Bacterial protein of unknown function (DUF965)
DXY22_RS16720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DXY22_RS16725	COG0628	permease
DXY22_RS16730	COG1126	abc transporter atp-binding protein
DXY22_RS16735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS16740	COG0765	amino acid transport
DXY22_RS16745	COG0765	amino acid transport
DXY22_RS16760	COG3881	PFAM PRC-barrel domain
DXY22_RS16765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DXY22_RS16770	COG0457	Tetratricopeptide repeat
DXY22_RS16775	COG0482	sulfurtransferase activity
DXY22_RS16780	COG1104	cysteine desulfurase activity
DXY22_RS16785	COG1959	2 iron, 2 sulfur cluster binding
DXY22_RS16790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DXY22_RS16795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DXY22_RS16805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DXY22_RS16810	COG0124	histidyl-tRNA synthetase
DXY22_RS16820	COG4991	sh3 domain protein
DXY22_RS16820	COG3103	Sh3 type 3 domain protein
DXY22_RS16820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS16825	COG1490	D-aminoacyl-tRNA deacylase activity
DXY22_RS16830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DXY22_RS16835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_RS16840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DXY22_RS16840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DXY22_RS16845	COG5416	Lipopolysaccharide assembly protein A domain
DXY22_RS16850	COG0490	domain, Protein
DXY22_RS16855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY22_RS16855	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY22_RS16865	COG2244	polysaccharide biosynthetic process
DXY22_RS16870	COG2323	membrane
DXY22_RS16880	COG1862	Preprotein translocase
DXY22_RS16885	COG0343	queuine tRNA-ribosyltransferase activity
DXY22_RS16890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DXY22_RS16900	COG2255	four-way junction helicase activity
DXY22_RS16905	COG0632	four-way junction helicase activity
DXY22_RS16915	COG2814	Major facilitator Superfamily
DXY22_RS16920	COG0673	inositol 2-dehydrogenase activity
DXY22_RS16925	COG2112	serine threonine protein kinase
DXY22_RS16945	COG1115	amino acid carrier protein
DXY22_RS16950	COG0217	transcriptional regulatory protein
DXY22_RS16960	COG1388	LysM domain
DXY22_RS16965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DXY22_RS16970	COG0157	Belongs to the NadC ModD family
DXY22_RS16975	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DXY22_RS16980	COG1104	cysteine desulfurase activity
DXY22_RS16985	COG1827	regulation of RNA biosynthetic process
DXY22_RS16990	COG0077	Prephenate dehydratase
DXY22_RS16995	COG4492	Belongs to the UPF0735 family
DXY22_RS17000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DXY22_RS17005	COG3290	protein histidine kinase activity
DXY22_RS17015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DXY22_RS17020	COG2868	ribosomal protein
DXY22_RS17025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DXY22_RS17030	COG1994	Peptidase M50
DXY22_RS17035	COG0739	heme binding
DXY22_RS17040	COG2894	cell division
DXY22_RS17045	COG0850	regulation of cytokinetic process
DXY22_RS17050	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DXY22_RS17055	COG1792	Involved in formation and maintenance of cell shape
DXY22_RS17060	COG1077	Cell shape determining protein MreB Mrl
DXY22_RS17065	COG2003	Belongs to the UPF0758 family
DXY22_RS17070	COG0424	maF-like protein
DXY22_RS17080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DXY22_RS17085	COG0285	dihydrofolate synthase activity
DXY22_RS17090	COG0525	valine-tRNA ligase activity
DXY22_RS17100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_RS17105	COG1388	LysM domain
DXY22_RS17110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DXY22_RS17115	COG0113	porphobilinogen synthase activity
DXY22_RS17120	COG1587	Uroporphyrinogen-III synthase
DXY22_RS17125	COG0181	hydroxymethylbilane synthase activity
DXY22_RS17130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY22_RS17135	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DXY22_RS17145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DXY22_RS17150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DXY22_RS17155	COG0470	DNA polymerase III
DXY22_RS17155	COG1067	ATP-dependent peptidase activity
DXY22_RS17160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DXY22_RS17165	COG0544	peptidyl-prolyl cis-trans isomerase activity
DXY22_RS17170	COG0457	Tetratricopeptide repeat
DXY22_RS17170	COG1477	protein flavinylation
DXY22_RS17175	COG0066	3-isopropylmalate dehydratase activity
DXY22_RS17180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DXY22_RS17185	COG0473	3-isopropylmalate dehydrogenase activity
DXY22_RS17190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DXY22_RS17195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DXY22_RS17200	COG0440	acetolactate synthase activity
DXY22_RS17205	COG0028	Belongs to the TPP enzyme family
DXY22_RS17215	COG0454	-acetyltransferase
DXY22_RS17220	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DXY22_RS17230	COG0622	Phosphoesterase
DXY22_RS17235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DXY22_RS17240	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DXY22_RS17245	COG5401	PFAM Sporulation and spore germination
DXY22_RS17250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DXY22_RS17255	COG1846	Transcriptional regulator
DXY22_RS17265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_RS17285	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_RS17285	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_RS17345	COG1388	LysM domain
DXY22_RS17345	COG0791	NLP P60 protein
DXY22_RS17350	COG5280	Phage tail tape measure protein TP901
DXY22_RS17350	COG3953	SLT domain
DXY22_RS17415	COG5484	DNA packaging
DXY22_RS17440	COG1595	DNA-templated transcription, initiation
DXY22_RS17495	COG1484	DNA-dependent DNA replication
DXY22_RS17505	COG3723	Recombinational DNA repair protein, rece pathway
DXY22_RS17510	COG5377	YqaJ viral recombinase family
DXY22_RS17535	COG3645	SOS response
DXY22_RS17535	COG3646	Phage regulatory protein
DXY22_RS17550	COG3620	sequence-specific DNA binding
DXY22_RS17560	COG2856	Zn peptidase
DXY22_RS17565	COG2197	response regulator
DXY22_RS17570	COG0824	Thioesterase
DXY22_RS17575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DXY22_RS17580	COG1053	succinate dehydrogenase
DXY22_RS17585	COG2009	succinate dehydrogenase
DXY22_RS17590	COG1719	4-vinyl reductase, 4VR
DXY22_RS17595	COG0527	aspartate kinase activity
DXY22_RS17600	COG0322	excinuclease ABC activity
DXY22_RS17605	COG3118	belongs to the thioredoxin family
DXY22_RS17610	COG3534	alpha-L-arabinofuranosidase
DXY22_RS17615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DXY22_RS17620	COG2086	electron transfer activity
DXY22_RS17625	COG1024	Enoyl-CoA hydratase
DXY22_RS17630	COG1309	transcriptional regulator
DXY22_RS17635	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS17640	COG3766	membrane
DXY22_RS17645	COG1193	negative regulation of DNA recombination
DXY22_RS17650	COG1796	DNA polymerase
DXY22_RS17650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY22_RS17655	COG1286	toxin biosynthetic process
DXY22_RS17660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DXY22_RS17665	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DXY22_RS17670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_RS17670	COG0072	phenylalanine-tRNA ligase activity
DXY22_RS17675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DXY22_RS17685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY22_RS17695	COG3835	regulator
DXY22_RS17700	COG0277	FAD linked oxidase domain protein
DXY22_RS17705	COG0247	lactate metabolic process
DXY22_RS17710	COG0346	lactoylglutathione lyase activity
DXY22_RS17720	COG1966	Carbon starvation protein
DXY22_RS17725	COG3534	alpha-L-arabinofuranosidase
DXY22_RS17730	COG0395	ABC-type sugar transport system, permease component
DXY22_RS17735	COG1175	transmembrane transport
DXY22_RS17740	COG1653	transport
DXY22_RS17745	COG0371	Dehydrogenase
DXY22_RS17750	COG0647	UMP catabolic process
DXY22_RS17755	COG0235	Class ii aldolase
DXY22_RS17760	COG1069	ribulokinase activity
DXY22_RS17765	COG2160	L-arabinose isomerase activity
DXY22_RS17770	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_RS17775	COG1363	Peptidase, m42
DXY22_RS17785	COG3326	Membrane
DXY22_RS17790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DXY22_RS17795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DXY22_RS17800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DXY22_RS17810	COG1346	cytolysis
DXY22_RS17815	COG1380	Effector of murein hydrolase LrgA
DXY22_RS17820	COG3279	Response regulator of the LytR AlgR family
DXY22_RS17825	COG3275	phosphorelay sensor kinase activity
DXY22_RS17835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DXY22_RS17845	COG0398	Pfam SNARE associated Golgi protein
DXY22_RS17850	COG1484	DNA-dependent DNA replication
DXY22_RS17855	COG3611	Membrane attachment protein
DXY22_RS17860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DXY22_RS17865	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DXY22_RS17870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY22_RS17875	COG1733	regulation of RNA biosynthetic process
DXY22_RS17880	COG2814	Major facilitator Superfamily
DXY22_RS17885	COG0656	L-ascorbic acid biosynthetic process
DXY22_RS17890	COG0237	dephospho-CoA kinase activity
DXY22_RS17895	COG1971	Probably functions as a manganese efflux pump
DXY22_RS17900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DXY22_RS17905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_RS17905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_RS17910	COG5002	protein histidine kinase activity
DXY22_RS17915	COG0745	RESPONSE REGULATOR receiver
DXY22_RS17920	COG0039	L-malate dehydrogenase activity
DXY22_RS17925	COG0538	isocitrate dehydrogenase activity
DXY22_RS17930	COG0372	Belongs to the citrate synthase family
DXY22_RS17935	COG2707	UPF0756 membrane protein
DXY22_RS17940	COG0628	permease
DXY22_RS17945	COG3030	protein affecting phage T7 exclusion by the F plasmid
DXY22_RS17950	COG0469	pyruvate kinase activity
DXY22_RS17955	COG0205	6-phosphofructokinase activity
DXY22_RS17960	COG0825	malonyl-CoA metabolic process
DXY22_RS17965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DXY22_RS17970	COG0281	malic enzyme
DXY22_RS17975	COG0587	DNA-directed DNA polymerase activity
DXY22_RS17995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DXY22_RS18005	COG4109	DRTGG domain
DXY22_RS18010	COG0730	response to heat
DXY22_RS18015	COG1473	amidohydrolase
DXY22_RS18020	COG0196	riboflavin kinase activity
DXY22_RS18025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS18030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DXY22_RS18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS18040	COG1126	abc transporter atp-binding protein
DXY22_RS18045	COG0765	amino acid transport
DXY22_RS18050	COG0765	amino acid transport
DXY22_RS18055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS18060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_RS18065	COG0454	-acetyltransferase
DXY22_RS18070	COG0583	DNA-binding transcription factor activity
DXY22_RS18075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DXY22_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS18090	COG0165	Argininosuccinate lyase
DXY22_RS18095	COG0137	argininosuccinate synthase activity
DXY22_RS18100	COG0521	Mo-molybdopterin cofactor biosynthetic process
DXY22_RS18105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DXY22_RS18115	COG0827	DNA restriction-modification system
DXY22_RS18120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DXY22_RS18125	COG3874	Sporulation protein YtfJ
DXY22_RS18135	COG1714	RDD family
DXY22_RS18140	COG0616	signal peptide processing
DXY22_RS18145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY22_RS18150	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DXY22_RS18155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY22_RS18165	COG0301	tRNA thio-modification
DXY22_RS18170	COG1104	cysteine desulfurase activity
DXY22_RS18175	COG1114	Component of the transport system for branched-chain amino acids
DXY22_RS18180	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DXY22_RS18185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY22_RS18190	COG1309	transcriptional regulator
DXY22_RS18195	COG1956	GAF domain-containing protein
DXY22_RS18200	COG2199	diguanylate cyclase activity
DXY22_RS18200	COG2203	Gaf domain
DXY22_RS18210	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DXY22_RS18215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DXY22_RS18220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY22_RS18225	COG0454	-acetyltransferase
DXY22_RS18230	COG0517	IMP dehydrogenase activity
DXY22_RS18235	COG0123	including yeast histone deacetylase and acetoin utilization protein
DXY22_RS18240	COG1360	Flagellar Motor Protein
DXY22_RS18245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY22_RS18250	COG1609	Transcriptional regulator
DXY22_RS18255	COG1605	Chorismate mutase
DXY22_RS18255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DXY22_RS18260	COG3118	belongs to the thioredoxin family
DXY22_RS18265	COG4980	gas vesicle protein
DXY22_RS18270	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY22_RS18275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DXY22_RS18280	COG1674	ftsk spoiiie
DXY22_RS18285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_RS18290	COG4848	Belongs to the UPF0354 family
DXY22_RS18295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS18310	COG1363	Peptidase, m42
DXY22_RS18315	COG5584	Small secreted protein
DXY22_RS18320	COG0281	malic enzyme
DXY22_RS18325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_RS18330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DXY22_RS18340	COG0510	thiamine kinase activity
DXY22_RS18345	COG1523	belongs to the glycosyl hydrolase 13 family
DXY22_RS18350	COG1597	lipid kinase activity
DXY22_RS18360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DXY22_RS18365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_RS18370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_RS18375	COG2252	PERMEase
DXY22_RS18380	COG4473	ABC transporter
DXY22_RS18385	COG1131	(ABC) transporter
DXY22_RS18390	COG1349	DNA-binding transcription factor activity
DXY22_RS18395	COG1187	pseudouridine synthase activity
DXY22_RS18400	COG2244	polysaccharide biosynthetic process
DXY22_RS18405	COG2081	HI0933 family
DXY22_RS18410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DXY22_RS18420	COG5578	integral membrane protein
DXY22_RS18425	COG0673	inositol 2-dehydrogenase activity
DXY22_RS18430	COG1653	transport
DXY22_RS18435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DXY22_RS18440	COG4209	transmembrane transport
DXY22_RS18445	COG2207	Transcriptional regulator
DXY22_RS18450	COG1653	transport
DXY22_RS18455	COG0395	ABC-type sugar transport system, permease component
DXY22_RS18460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_RS18465	COG2124	cytochrome p450
DXY22_RS18470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DXY22_RS18480	COG0156	8-amino-7-oxononanoate synthase activity
DXY22_RS18485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_RS18495	COG1073	alpha beta
DXY22_RS18520	COG1486	melibiose metabolic process
DXY22_RS18525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_RS18530	COG0495	leucyl-tRNA aminoacylation
DXY22_RS18540	COG2202	Pas domain
DXY22_RS18540	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_RS18545	COG2814	Major facilitator Superfamily
DXY22_RS18555	COG0577	efflux transmembrane transporter activity
DXY22_RS18560	COG1136	(ABC) transporter
DXY22_RS18565	COG2205	protein histidine kinase activity
DXY22_RS18570	COG0745	RESPONSE REGULATOR receiver
DXY22_RS18575	COG0577	efflux transmembrane transporter activity
DXY22_RS18580	COG1136	(ABC) transporter
DXY22_RS18595	COG1131	(ABC) transporter
DXY22_RS18600	COG1725	Transcriptional regulator
DXY22_RS18615	COG1242	4 iron, 4 sulfur cluster binding
DXY22_RS18620	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DXY22_RS18630	COG2267	carboxylic ester hydrolase activity
DXY22_RS18635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DXY22_RS18640	COG1113	amino acid transport
DXY22_RS18645	COG0367	asparagine synthase
DXY22_RS18650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DXY22_RS18655	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DXY22_RS18665	COG1506	peptidase
DXY22_RS18670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY22_RS18675	COG1116	anion transmembrane transporter activity
DXY22_RS18680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY22_RS18685	COG0494	nUDIX hydrolase
DXY22_RS18690	COG4824	toxin secretion phage lysis holin
DXY22_RS18695	COG0783	Belongs to the Dps family
DXY22_RS18710	COG1854	S-ribosylhomocysteine lyase activity
DXY22_RS18715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DXY22_RS18720	COG0288	reversible hydration of carbon dioxide
DXY22_RS18725	COG0254	rRNA binding
DXY22_RS18730	COG1271	oxidase subunit
DXY22_RS18735	COG1294	oxidase, subunit
DXY22_RS18745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_RS18750	COG1321	iron dependent repressor
DXY22_RS18750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_RS18755	COG1121	(ABC) transporter
DXY22_RS18760	COG0803	Belongs to the bacterial solute-binding protein 9 family
DXY22_RS18765	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_RS18770	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_RS18775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DXY22_RS18780	COG0596	Alpha beta hydrolase
DXY22_RS18785	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DXY22_RS18790	COG1169	isochorismate synthase
DXY22_RS18795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_RS18800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_RS18805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_RS18810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_RS18815	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS18825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_RS18830	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS18835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_RS18840	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DXY22_RS18845	COG0058	SHG alpha-glucan phosphorylase activity
DXY22_RS18850	COG0297	glycogen (starch) synthase activity
DXY22_RS18855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DXY22_RS18860	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DXY22_RS18865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DXY22_RS18990	COG3859	Proton-coupled thiamine transporter YuaJ
DXY22_RS18995	COG1247	-acetyltransferase
DXY22_RS19000	COG2268	Band 7 protein
DXY22_RS19005	COG1585	Membrane protein implicated in regulation of membrane protease activity
DXY22_RS19010	COG2318	DinB family
DXY22_RS19020	COG1454	alcohol dehydrogenase
DXY22_RS19030	COG1510	regulation of RNA biosynthetic process
DXY22_RS19040	COG0569	domain protein
DXY22_RS19045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DXY22_RS19050	COG4682	membrane
DXY22_RS19055	COG1705	Flagellar rod assembly protein muramidase FlgJ
DXY22_RS19060	COG0477	Major facilitator Superfamily
DXY22_RS19065	COG5553	Cysteine dioxygenase type I
DXY22_RS19075	COG1968	undecaprenyl-diphosphatase activity
DXY22_RS19080	COG0628	permease
DXY22_RS19085	COG0673	inositol 2-dehydrogenase activity
DXY22_RS19090	COG4806	L-rhamnose isomerase
DXY22_RS19095	COG3254	rhamnose metabolic process
DXY22_RS19100	COG1070	Carbohydrate kinase
DXY22_RS19105	COG1349	DNA-binding transcription factor activity
DXY22_RS19110	COG3347	Dehydrogenase
DXY22_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS19115	COG0840	transmembrane signaling receptor activity
DXY22_RS19120	COG0840	transmembrane signaling receptor activity
DXY22_RS19125	COG0840	transmembrane signaling receptor activity
DXY22_RS19130	COG0840	transmembrane signaling receptor activity
DXY22_RS19145	COG0432	Pfam Uncharacterised protein family UPF0047
DXY22_RS19155	COG0366	Alpha amylase catalytic
DXY22_RS19160	COG1253	flavin adenine dinucleotide binding
DXY22_RS19165	COG2738	Putative neutral zinc metallopeptidase
DXY22_RS19180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DXY22_RS19195	COG0166	Belongs to the GPI family
DXY22_RS19200	COG1979	alcohol dehydrogenase
DXY22_RS19205	COG1979	alcohol dehydrogenase
DXY22_RS19210	COG2155	Conserved Protein
DXY22_RS19215	COG1098	S1 RNA binding domain
DXY22_RS19220	COG0436	Aminotransferase
DXY22_RS19225	COG1522	sequence-specific DNA binding
DXY22_RS19230	COG2267	carboxylic ester hydrolase activity
DXY22_RS19240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DXY22_RS19245	COG2205	protein histidine kinase activity
DXY22_RS19255	COG5018	Exonuclease
DXY22_RS19265	COG2814	Major facilitator Superfamily
DXY22_RS19270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_RS19275	COG3011	Protein conserved in bacteria
DXY22_RS19285	COG3290	protein histidine kinase activity
DXY22_RS19290	COG4565	transcriptional regulatory protein
DXY22_RS19315	COG3493	citrate carrier protein
DXY22_RS19325	COG2111	Na H antiporter
DXY22_RS19325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DXY22_RS19330	COG2111	Na H antiporter
DXY22_RS19335	COG1006	Multisubunit Na H antiporter MnhC subunit
DXY22_RS19340	COG0651	ATP synthesis coupled electron transport
DXY22_RS19345	COG1863	multisubunit Na H antiporter MnhE subunit
DXY22_RS19350	COG2212	antiporter activity
DXY22_RS19355	COG1320	monovalent cation:proton antiporter activity
DXY22_RS19360	COG2050	protein possibly involved in aromatic compounds catabolism
DXY22_RS19365	COG2197	response regulator
DXY22_RS19370	COG4585	Histidine kinase
DXY22_RS19380	COG0142	geranyltranstransferase activity
DXY22_RS19400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DXY22_RS19405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DXY22_RS19410	COG1335	isochorismatase
DXY22_RS19415	COG5506	Protein of unknown function (DUF1694)
DXY22_RS19430	COG0628	permease
DXY22_RS19445	COG1418	mRNA catabolic process
DXY22_RS19450	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS19460	COG1511	domain protein
DXY22_RS19465	COG1674	ftsk spoiiie
DXY22_RS19465	COG0433	COG0433 Predicted ATPase
DXY22_RS19470	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY22_RS19475	COG5417	Belongs to the EsaB family
DXY22_RS19480	COG4842	Belongs to the WXG100 family
DXY22_RS19485	COG2508	Transcriptional regulator
DXY22_RS19485	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DXY22_RS19490	COG0686	Belongs to the AlaDH PNT family
DXY22_RS19495	COG5634	Uncharacterized conserved protein (DUF2278)
DXY22_RS19500	COG3251	PFAM MbtH domain protein
DXY22_RS19505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_RS19510	COG1535	isochorismatase
DXY22_RS19510	COG3433	isochorismatase activity
DXY22_RS19515	COG1021	2,3-dihydroxybenzoate-AMP ligase
DXY22_RS19520	COG1169	isochorismate synthase
DXY22_RS19525	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS19530	COG2819	hydrolase of the alpha beta superfamily
DXY22_RS19535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY22_RS19540	COG1268	BioY protein
DXY22_RS19545	COG2056	Na+-H+ antiporter family
DXY22_RS19550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DXY22_RS19555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DXY22_RS19560	COG3584	3D domain protein
DXY22_RS19575	COG1252	NADH dehydrogenase
DXY22_RS19580	COG0492	ferredoxin-NADP+ reductase activity
DXY22_RS19590	COG0516	GMP reductase activity
DXY22_RS19595	COG2808	Putative FMN-binding domain
DXY22_RS19600	COG0456	acetyltransferase
DXY22_RS19605	COG0316	Belongs to the HesB IscA family
DXY22_RS19610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DXY22_RS19615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_RS19620	COG4844	belongs to the
DXY22_RS19625	COG1252	NADH dehydrogenase
DXY22_RS19630	COG4837	Protein of unknown function (DUF1462)
DXY22_RS19635	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DXY22_RS19640	COG1506	peptidase
DXY22_RS19640	COG0823	Involved in the tonB-independent uptake of proteins
DXY22_RS19640	COG4946	Tricorn protease homolog
DXY22_RS19645	COG0083	homoserine kinase activity
DXY22_RS19650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DXY22_RS19655	COG0460	homoserine dehydrogenase
DXY22_RS19660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_RS19665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DXY22_RS19670	COG0647	UMP catabolic process
DXY22_RS19675	COG2445	Protein of unknown function DUF86
DXY22_RS19680	COG4470	Protein conserved in bacteria
DXY22_RS19690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DXY22_RS19695	COG0739	heme binding
DXY22_RS19705	COG3377	Domain of unknown function (DUF1805)
DXY22_RS19710	COG0737	Belongs to the 5'-nucleotidase family
DXY22_RS19715	COG0730	response to heat
DXY22_RS19720	COG1801	Protein of unknown function DUF72
DXY22_RS19730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DXY22_RS19735	COG2508	Transcriptional regulator
DXY22_RS19740	COG2233	PERMEase
DXY22_RS19745	COG2233	PERMEase
DXY22_RS19755	COG2351	hydroxyisourate hydrolase activity
DXY22_RS19765	COG2080	2 iron, 2 sulfur cluster binding
DXY22_RS19770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DXY22_RS19775	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DXY22_RS19780	COG2068	MobA-Related Protein
DXY22_RS19785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DXY22_RS19790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DXY22_RS19795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_RS19805	COG2356	endonuclease I
DXY22_RS19810	COG3842	ATPase activity
DXY22_RS19815	COG2188	Transcriptional regulator
DXY22_RS19820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_RS19825	COG0395	ABC-type sugar transport system, permease component
DXY22_RS19830	COG1175	transmembrane transport
DXY22_RS19835	COG1653	transport
DXY22_RS19840	COG2222	sugar isomerase
DXY22_RS19845	COG0322	excinuclease ABC activity
DXY22_RS19850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_RS19870	COG0640	Transcriptional regulator
DXY22_RS19875	COG0719	Fe-S assembly protein
DXY22_RS19880	COG0822	iron-sulfur transferase activity
DXY22_RS19885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY22_RS19890	COG0719	Fe-S assembly protein
DXY22_RS19895	COG0396	ATPase activity
DXY22_RS19905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DXY22_RS19910	COG1464	Belongs to the NlpA lipoprotein family
DXY22_RS19915	COG2011	ABC-type metal ion transport system permease component
DXY22_RS19920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DXY22_RS19930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_RS19935	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY22_RS19945	COG0509	glycine decarboxylation via glycine cleavage system
DXY22_RS19950	COG1393	Belongs to the ArsC family
DXY22_RS19955	COG1960	acyl-CoA dehydrogenase activity
DXY22_RS19960	COG0183	Belongs to the thiolase family
DXY22_RS19965	COG1024	Enoyl-CoA hydratase
DXY22_RS19965	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY22_RS19985	COG5577	PFAM Coat F domain
DXY22_RS19990	COG1846	Transcriptional regulator
DXY22_RS19995	COG0477	Major facilitator Superfamily
DXY22_RS20000	COG1942	4-Oxalocrotonate Tautomerase
DXY22_RS20005	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS20010	COG0583	DNA-binding transcription factor activity
DXY22_RS20020	COG1120	ATPase activity
DXY22_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS20040	COG0783	Belongs to the Dps family
DXY22_RS20045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_RS20050	COG0745	RESPONSE REGULATOR receiver
DXY22_RS20055	COG2205	protein histidine kinase activity
DXY22_RS20055	COG2770	Histidine kinase
DXY22_RS20065	COG1309	transcriptional regulator
DXY22_RS20070	COG0114	fumarate hydratase activity
DXY22_RS20080	COG0697	spore germination
DXY22_RS20085	COG0814	amino acid
DXY22_RS20095	COG2197	response regulator
DXY22_RS20100	COG4585	Histidine kinase
DXY22_RS20105	COG4758	membrane
DXY22_RS20110	COG3595	metallopeptidase activity
DXY22_RS20115	COG1842	Phage shock protein A
DXY22_RS20120	COG4758	membrane
DXY22_RS20125	COG2814	Major facilitator Superfamily
DXY22_RS20130	COG2096	Adenosyltransferase
DXY22_RS20135	COG1120	ATPase activity
DXY22_RS20140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS20145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS20155	COG3386	PFAM SMP-30 Gluconolaconase
DXY22_RS20160	COG2205	protein histidine kinase activity
DXY22_RS20165	COG0745	RESPONSE REGULATOR receiver
DXY22_RS20175	COG1191	sigma factor activity
DXY22_RS20185	COG2140	Oxalate decarboxylase
DXY22_RS20195	COG0577	efflux transmembrane transporter activity
DXY22_RS20200	COG1136	(ABC) transporter
DXY22_RS20205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DXY22_RS20210	COG1120	ATPase activity
DXY22_RS20215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS20220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_RS20225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_RS20230	COG0531	amino acid
DXY22_RS20240	COG1988	membrane-bound metal-dependent
DXY22_RS20245	COG1368	sulfuric ester hydrolase activity
DXY22_RS20250	COG1910	domain protein
DXY22_RS20255	COG0725	ABC transporter, periplasmic molybdate-binding protein
DXY22_RS20260	COG4149	molybdate abc transporter
DXY22_RS20265	COG0656	L-ascorbic acid biosynthetic process
DXY22_RS20275	COG0025	NhaP-type Na H and K H
DXY22_RS20280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_RS20285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_RS20290	COG3973	AAA domain
DXY22_RS20300	COG2860	membrane
DXY22_RS20305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DXY22_RS20310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DXY22_RS20315	COG2217	Heavy metal translocating P-type atpase
DXY22_RS20320	COG2217	Heavy metal translocating P-type atpase
DXY22_RS20325	COG2608	mercury ion transmembrane transporter activity
DXY22_RS20330	COG1937	Protein conserved in bacteria
DXY22_RS20335	COG0673	inositol 2-dehydrogenase activity
DXY22_RS20340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DXY22_RS20345	COG1289	transmembrane transporter activity
DXY22_RS20355	COG2076	Multidrug Resistance protein
DXY22_RS20360	COG1309	transcriptional regulator
DXY22_RS20365	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_RS20375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DXY22_RS20380	COG0557	exoribonuclease II activity
DXY22_RS20385	COG1647	Serine aminopeptidase, S33
DXY22_RS20390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY22_RS20395	COG0596	Alpha beta hydrolase
DXY22_RS20400	COG1476	TRANSCRIPTIONal
DXY22_RS20405	COG1396	sequence-specific DNA binding
DXY22_RS20410	COG1396	sequence-specific DNA binding
DXY22_RS20415	COG1733	regulation of RNA biosynthetic process
DXY22_RS20420	COG0840	transmembrane signaling receptor activity
DXY22_RS20425	COG1174	glycine betaine transport
DXY22_RS20430	COG1732	Glycine betaine
DXY22_RS20435	COG1174	glycine betaine transport
DXY22_RS20440	COG1125	glycine betaine transport
DXY22_RS20440	COG0517	IMP dehydrogenase activity
DXY22_RS20445	COG1510	regulation of RNA biosynthetic process
DXY22_RS20465	COG5658	integral membrane protein
DXY22_RS20470	COG0640	Transcriptional regulator
DXY22_RS20475	COG1174	glycine betaine transport
DXY22_RS20480	COG1732	Glycine betaine
DXY22_RS20485	COG1174	glycine betaine transport
DXY22_RS20490	COG0517	IMP dehydrogenase activity
DXY22_RS20490	COG1125	glycine betaine transport
DXY22_RS20495	COG1510	regulation of RNA biosynthetic process
DXY22_RS20500	COG2095	MarC family integral membrane protein
DXY22_RS20510	COG3064	Membrane
DXY22_RS20515	COG4640	response to antibiotic
DXY22_RS20520	COG0456	acetyltransferase
DXY22_RS20525	COG0148	phosphopyruvate hydratase activity
DXY22_RS20530	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DXY22_RS20535	COG0149	triose-phosphate isomerase activity
DXY22_RS20540	COG0126	phosphoglycerate kinase activity
DXY22_RS20545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY22_RS20550	COG2390	Transcriptional regulator
DXY22_RS20555	COG2814	Major facilitator Superfamily
DXY22_RS20560	COG1609	Transcriptional regulator
DXY22_RS20565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_RS20570	COG0583	DNA-binding transcription factor activity
DXY22_RS20575	COG0697	spore germination
DXY22_RS20580	COG1113	amino acid transport
DXY22_RS20585	COG3858	chitin binding
DXY22_RS20590	COG1556	Lactate utilization protein
DXY22_RS20595	COG1139	Iron-sulfur cluster binding protein
DXY22_RS20600	COG0247	lactate metabolic process
DXY22_RS20605	COG2197	response regulator
DXY22_RS20610	COG4585	Histidine kinase
DXY22_RS20615	COG0842	Transport permease protein
DXY22_RS20620	COG1131	(ABC) transporter
DXY22_RS20625	COG0596	Alpha beta hydrolase
DXY22_RS20630	COG2208	phosphoserine phosphatase activity
DXY22_RS20635	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DXY22_RS20640	COG1874	Beta-galactosidase
DXY22_RS20645	COG3833	ABC-type maltose transport systems, permease component
DXY22_RS20650	COG1175	transmembrane transport
DXY22_RS20655	COG2182	Extracellular solute-binding protein
DXY22_RS20660	COG1609	Transcriptional regulator
DXY22_RS20665	COG2186	Transcriptional regulator
DXY22_RS20670	COG1620	l-lactate permease
DXY22_RS20675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DXY22_RS20685	COG5039	Polysaccharide pyruvyl transferase
DXY22_RS20690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_RS20695	COG0110	maltose O-acetyltransferase activity
DXY22_RS20700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DXY22_RS20705	COG2244	polysaccharide biosynthetic process
DXY22_RS20710	COG1216	Glycosyl transferase, family 2
DXY22_RS20715	COG5039	Polysaccharide pyruvyl transferase
DXY22_RS20720	COG1216	Glycosyl transferase, family 2
DXY22_RS20730	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS20735	COG1215	transferase activity, transferring glycosyl groups
DXY22_RS20740	COG0438	transferase activity, transferring glycosyl groups
DXY22_RS20745	COG1086	Polysaccharide biosynthesis protein
DXY22_RS20750	COG0489	protein tyrosine kinase activity
DXY22_RS20755	COG3944	biosynthesis protein
DXY22_RS20760	COG1396	sequence-specific DNA binding
DXY22_RS20765	COG2272	Belongs to the type-B carboxylesterase lipase family
DXY22_RS20775	COG3479	Phenolic acid decarboxylase
DXY22_RS20785	COG1794	racemase activity, acting on amino acids and derivatives
DXY22_RS20790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_RS20795	COG1621	beta-fructofuranosidase activity
DXY22_RS20800	COG1621	beta-fructofuranosidase activity
DXY22_RS20805	COG0531	amino acid
DXY22_RS20810	COG1309	transcriptional regulator
DXY22_RS20815	COG2076	Multidrug Resistance protein
DXY22_RS20820	COG2076	Multidrug Resistance protein
DXY22_RS20830	COG0277	FAD linked oxidase domain protein
DXY22_RS20835	COG3621	Patatin-like phospholipase
DXY22_RS20845	COG0740	serine-type endopeptidase activity
DXY22_RS20850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DXY22_RS20855	COG0366	Alpha amylase catalytic
DXY22_RS20860	COG1554	hydrolase, family 65, central catalytic
DXY22_RS20865	COG5521	maltodextrose utilization protein MalA
DXY22_RS20870	COG3833	ABC-type maltose transport systems, permease component
DXY22_RS20875	COG1175	transmembrane transport
DXY22_RS20880	COG2182	Extracellular solute-binding protein
DXY22_RS20890	COG1609	Transcriptional regulator
DXY22_RS20895	COG1611	Belongs to the LOG family
DXY22_RS20900	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY22_RS20905	COG0659	secondary active sulfate transmembrane transporter activity
DXY22_RS20910	COG0288	reversible hydration of carbon dioxide
DXY22_RS20915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY22_RS20920	COG0577	efflux transmembrane transporter activity
DXY22_RS20925	COG1136	(ABC) transporter
DXY22_RS20930	COG5002	protein histidine kinase activity
DXY22_RS20935	COG0745	RESPONSE REGULATOR receiver
DXY22_RS20945	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DXY22_RS20950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_RS20955	COG1481	regulation of sporulation
DXY22_RS20960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DXY22_RS20965	COG1660	Displays ATPase and GTPase activities
DXY22_RS20970	COG1051	belongs to the nudix hydrolase family
DXY22_RS20975	COG0492	ferredoxin-NADP+ reductase activity
DXY22_RS20980	COG3883	PFAM NLP P60 protein
DXY22_RS20980	COG0791	NLP P60 protein
DXY22_RS20985	COG0457	Tetratricopeptide repeat
DXY22_RS20990	COG1132	(ABC) transporter