locus-tag	class	description
ES969_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES969_RS00010	COG0592	DNA-directed DNA polymerase activity
ES969_RS00015	COG2501	S4 domain
ES969_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES969_RS00030	COG0187	DNA topoisomerase II activity
ES969_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES969_RS00070	COG0517	IMP dehydrogenase activity
ES969_RS00070	COG0516	GMP reductase activity
ES969_RS00075	COG1686	Belongs to the peptidase S11 family
ES969_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES969_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES969_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES969_RS00100	COG1428	Deoxynucleoside kinase
ES969_RS00105	COG1428	Deoxynucleoside kinase
ES969_RS00110	COG3858	chitin binding
ES969_RS00110	COG1388	LysM domain
ES969_RS00120	COG0590	tRNA wobble adenosine to inosine editing
ES969_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES969_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES969_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES969_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES969_RS00190	COG3853	Toxic anion resistance protein (TelA)
ES969_RS00195	COG1982	Orn Lys Arg decarboxylase major
ES969_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES969_RS00205	COG3870	Protein conserved in bacteria
ES969_RS00210	COG1728	Protein conserved in bacteria
ES969_RS00215	COG0470	DNA polymerase III
ES969_RS00220	COG1774	PSP1 C-terminal conserved region
ES969_RS00225	COG4467	Involved in initiation control of chromosome replication
ES969_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES969_RS00235	COG2827	Endonuclease containing a URI domain
ES969_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES969_RS00255	COG2002	toxin-antitoxin pair type II binding
ES969_RS00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_RS00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_RS00265	COG0084	hydrolase, TatD family'
ES969_RS00270	COG3584	3D domain protein
ES969_RS00270	COG3583	domain protein
ES969_RS00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES969_RS00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES969_RS00290	COG4466	Protein conserved in bacteria
ES969_RS00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES969_RS00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_RS00310	COG0251	oxidation-reduction process
ES969_RS00315	COG2088	sporulation resulting in formation of a cellular spore
ES969_RS00320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES969_RS00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES969_RS00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES969_RS00335	COG0193	aminoacyl-tRNA hydrolase activity
ES969_RS00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES969_RS00350	COG2002	toxin-antitoxin pair type II binding
ES969_RS00355	COG2244	polysaccharide biosynthetic process
ES969_RS00360	COG3956	TIGRFAM MazG family protein
ES969_RS00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES969_RS00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES969_RS00385	COG1098	S1 RNA binding domain
ES969_RS00400	COG2208	phosphoserine phosphatase activity
ES969_RS00405	COG2304	oxidoreductase activity
ES969_RS00410	COG0515	serine threonine protein kinase
ES969_RS00415	COG0037	tRNA processing
ES969_RS00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ES969_RS00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES969_RS00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES969_RS00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES969_RS00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES969_RS00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_RS00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES969_RS00455	COG0512	Glutamine amidotransferase of anthranilate synthase
ES969_RS00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_RS00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES969_RS00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES969_RS00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES969_RS00480	COG1396	sequence-specific DNA binding
ES969_RS00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES969_RS00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES969_RS00570	COG4463	regulation of RNA biosynthetic process
ES969_RS00575	COG3880	PFAM UvrB UvrC protein
ES969_RS00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES969_RS00585	COG0542	response to heat
ES969_RS00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES969_RS00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES969_RS00600	COG4956	integral membrane protein (PIN domain superfamily)
ES969_RS00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES969_RS00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES969_RS00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES969_RS00625	COG1045	serine acetyltransferase
ES969_RS00630	COG0215	cysteine-tRNA ligase activity
ES969_RS00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES969_RS00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES969_RS00645	COG3688	RNA-binding protein containing a PIN domain
ES969_RS00650	COG1595	DNA-templated transcription, initiation
ES969_RS00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES969_RS00665	COG0250	Participates in transcription elongation, termination and antitermination
ES969_RS00675	COG0081	regulation of translation
ES969_RS00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES969_RS00690	COG2813	Specifically methylates the guanine in position
ES969_RS00695	COG0085	RNA polymerase activity
ES969_RS00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES969_RS00705	COG1358	cellular component organization or biogenesis
ES969_RS00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES969_RS00715	COG0049	tRNA binding
ES969_RS00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES969_RS00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES969_RS00730	COG0596	Alpha beta hydrolase
ES969_RS00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES969_RS00745	COG0088	Forms part of the polypeptide exit tunnel
ES969_RS00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES969_RS00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES969_RS00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES969_RS00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES969_RS00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES969_RS00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES969_RS00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES969_RS00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES969_RS00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES969_RS00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES969_RS00835	COG0200	Binds to the 23S rRNA
ES969_RS00840	COG0201	protein transport
ES969_RS00845	COG0563	adenylate kinase activity
ES969_RS00850	COG0024	Methionine aminopeptidase
ES969_RS00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES969_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES969_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES969_RS00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES969_RS00880	COG0202	RNA polymerase activity
ES969_RS00885	COG0203	ribosomal protein L17
ES969_RS00890	COG1122	ATPase activity
ES969_RS00895	COG1122	ATPase activity
ES969_RS00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES969_RS00905	COG0101	tRNA pseudouridine synthase activity
ES969_RS00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES969_RS00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES969_RS00920	COG2226	methyltransferase
ES969_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS00935	COG0489	protein tyrosine kinase activity
ES969_RS00945	COG2194	sulfuric ester hydrolase activity
ES969_RS00950	COG0726	polysaccharide deacetylase
ES969_RS01035	COG0659	secondary active sulfate transmembrane transporter activity
ES969_RS01040	COG0385	Bile acid
ES969_RS01045	COG2819	hydrolase of the alpha beta superfamily
ES969_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS01065	COG2207	Transcriptional regulator
ES969_RS01070	COG3876	Protein conserved in bacteria
ES969_RS01075	COG1472	Belongs to the glycosyl hydrolase 3 family
ES969_RS01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES969_RS01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS01085	COG1263	PTS System
ES969_RS01090	COG1737	Transcriptional regulator
ES969_RS01095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES969_RS01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS01105	COG1683	Conserved Protein
ES969_RS01135	COG1595	DNA-templated transcription, initiation
ES969_RS01140	COG5662	AntiSigma factor
ES969_RS01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES969_RS01150	COG4856	YbbR-like protein
ES969_RS01155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES969_RS01160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES969_RS01170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES969_RS01175	COG2169	Transcriptional regulator
ES969_RS01180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES969_RS01185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES969_RS01190	COG3002	Belongs to the UPF0753 family
ES969_RS01195	COG0288	reversible hydration of carbon dioxide
ES969_RS01205	COG5609	conserved protein (DUF2294)
ES969_RS01215	COG0642	Histidine kinase
ES969_RS01225	COG0515	serine threonine protein kinase
ES969_RS01240	COG1113	amino acid transport
ES969_RS01255	COG2602	Beta-lactamase
ES969_RS01260	COG2124	cytochrome p450
ES969_RS01270	COG0531	amino acid
ES969_RS01275	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_RS01280	COG2271	Major facilitator Superfamily
ES969_RS01295	COG0456	acetyltransferase
ES969_RS01295	COG1846	Transcriptional regulator
ES969_RS01315	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS01320	COG0697	spore germination
ES969_RS01325	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS01325	COG2207	Transcriptional regulator
ES969_RS01350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES969_RS01355	COG3591	Belongs to the peptidase S1B family
ES969_RS01365	COG0596	Alpha beta hydrolase
ES969_RS01370	COG1183	phosphatidylcholine synthase activity
ES969_RS01375	COG0586	Pfam SNARE associated Golgi protein
ES969_RS01380	COG0688	phosphatidylethanolamine metabolic process
ES969_RS01390	COG2312	Erythromycin esterase
ES969_RS01395	COG2207	Transcriptional regulator
ES969_RS01400	COG1054	Belongs to the UPF0176 family
ES969_RS01405	COG1301	dicarboxylic acid transport
ES969_RS01410	COG2190	(PTS) system
ES969_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS01410	COG1263	PTS System
ES969_RS01415	COG0363	glucosamine-6-phosphate deaminase activity
ES969_RS01420	COG2188	Transcriptional regulator
ES969_RS01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_RS01435	COG0833	amino acid
ES969_RS01440	COG2040	homocysteine
ES969_RS01450	COG1115	amino acid carrier protein
ES969_RS01455	COG2066	Belongs to the glutaminase family
ES969_RS01460	COG4191	Histidine kinase
ES969_RS01465	COG0784	Response regulator, receiver
ES969_RS01475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES969_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS01485	COG2271	Major facilitator Superfamily
ES969_RS01490	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_RS01495	COG2186	Transcriptional regulator
ES969_RS01500	COG2721	sulfolactate sulfo-lyase activity
ES969_RS01505	COG3173	Aminoglycoside phosphotransferase
ES969_RS01515	COG0697	spore germination
ES969_RS01520	COG0745	RESPONSE REGULATOR receiver
ES969_RS01525	COG2205	protein histidine kinase activity
ES969_RS01530	COG1131	(ABC) transporter
ES969_RS01550	COG3773	Cell wall hydrolase
ES969_RS01555	COG2304	oxidoreductase activity
ES969_RS01565	COG3540	Alkaline phosphatase
ES969_RS01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_RS01575	COG0805	protein transport
ES969_RS01580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES969_RS01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES969_RS01590	COG0477	Major facilitator Superfamily
ES969_RS01595	COG1309	transcriptional regulator
ES969_RS01600	COG0252	asparaginase activity
ES969_RS01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES969_RS01610	COG1714	RDD family
ES969_RS01615	COG3012	SEC-C Motif Domain Protein
ES969_RS01615	COG1405	negative regulation of cell septum assembly
ES969_RS01620	COG3290	protein histidine kinase activity
ES969_RS01625	COG3279	Response regulator of the LytR AlgR family
ES969_RS01630	COG4555	ABC transporter
ES969_RS01635	COG1668	transmembrane transport
ES969_RS01640	COG0667	Aldo Keto reductase
ES969_RS01655	COG1595	DNA-templated transcription, initiation
ES969_RS01660	COG1595	DNA-templated transcription, initiation
ES969_RS01665	COG1876	peptidase activity
ES969_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS01680	COG0366	Alpha amylase catalytic
ES969_RS01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES969_RS01690	COG1121	(ABC) transporter
ES969_RS01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_RS01705	COG2310	stress, protein
ES969_RS01710	COG2310	stress, protein
ES969_RS01715	COG2310	stress, protein
ES969_RS01720	COG0861	Integral membrane protein TerC family
ES969_RS01730	COG3853	Toxic anion resistance protein (TelA)
ES969_RS01740	COG0477	Major facilitator Superfamily
ES969_RS01745	COG2814	Major facilitator Superfamily
ES969_RS01750	COG0640	Transcriptional regulator
ES969_RS01755	COG4175	Glycine betaine
ES969_RS01755	COG0517	IMP dehydrogenase activity
ES969_RS01760	COG4176	ABC-type proline glycine betaine transport system permease component
ES969_RS01765	COG2113	Glycine betaine
ES969_RS01770	COG1473	amidohydrolase
ES969_RS01775	COG1288	antiporter activity
ES969_RS01790	COG0039	L-malate dehydrogenase activity
ES969_RS01795	COG1620	l-lactate permease
ES969_RS01805	COG3403	YqcI/YcgG family
ES969_RS01810	COG1113	amino acid transport
ES969_RS01815	COG3665	Urea carboxylase-associated protein
ES969_RS01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES969_RS01825	COG1660	Displays ATPase and GTPase activities
ES969_RS01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES969_RS01845	COG2226	methyltransferase
ES969_RS01850	COG0583	DNA-binding transcription factor activity
ES969_RS01855	COG3458	cephalosporin-C deacetylase activity
ES969_RS01860	COG3541	Predicted nucleotidyltransferase
ES969_RS01865	COG0506	proline dehydrogenase activity
ES969_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_RS01880	COG2508	Transcriptional regulator
ES969_RS01885	COG3689	TIGRFAM TIGR03943 family protein
ES969_RS01890	COG0701	Predicted permease
ES969_RS01895	COG2267	carboxylic ester hydrolase activity
ES969_RS01900	COG0492	ferredoxin-NADP+ reductase activity
ES969_RS01905	COG1587	Uroporphyrinogen-III synthase
ES969_RS01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES969_RS01910	COG2146	nitrite reductase [NAD(P)H] activity
ES969_RS01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_RS01920	COG0243	molybdopterin cofactor binding
ES969_RS01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_RS01930	COG2223	nitrite transmembrane transporter activity
ES969_RS01940	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_RS01955	COG0765	amino acid transport
ES969_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_RS01970	COG1714	RDD family
ES969_RS01980	COG1846	Transcriptional regulator
ES969_RS01995	COG2723	6-phospho-beta-galactosidase activity
ES969_RS02005	COG3209	COG3209 Rhs family protein
ES969_RS02010	COG0840	transmembrane signaling receptor activity
ES969_RS02010	COG3290	protein histidine kinase activity
ES969_RS02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES969_RS02020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES969_RS02025	COG1733	regulation of RNA biosynthetic process
ES969_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES969_RS02050	COG2814	Major facilitator Superfamily
ES969_RS02060	COG0697	spore germination
ES969_RS02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS02080	COG2364	Membrane
ES969_RS02085	COG1126	abc transporter atp-binding protein
ES969_RS02090	COG0765	amino acid transport
ES969_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_RS02100	COG0583	DNA-binding transcription factor activity
ES969_RS02105	COG0163	prenyltransferase activity
ES969_RS02110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES969_RS02125	COG0596	Alpha beta hydrolase
ES969_RS02130	COG3104	oligopeptide transport
ES969_RS02135	COG5434	Belongs to the glycosyl hydrolase 28 family
ES969_RS02145	COG0697	spore germination
ES969_RS02155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES969_RS02160	COG1136	(ABC) transporter
ES969_RS02165	COG0577	efflux transmembrane transporter activity
ES969_RS02170	COG0745	RESPONSE REGULATOR receiver
ES969_RS02175	COG3850	Histidine kinase
ES969_RS02175	COG5002	protein histidine kinase activity
ES969_RS02180	COG0457	Tetratricopeptide repeat
ES969_RS02200	COG0527	aspartate kinase activity
ES969_RS02205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS02210	COG4605	iron ion homeostasis
ES969_RS02215	COG4604	ABC transporter, ATP-binding protein
ES969_RS02220	COG4607	ABC-type enterochelin transport system periplasmic component
ES969_RS02230	COG2814	Major facilitator Superfamily
ES969_RS02235	COG1309	transcriptional regulator
ES969_RS02240	COG0778	Nitroreductase
ES969_RS02245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES969_RS02250	COG0640	Transcriptional regulator
ES969_RS02255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES969_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS02270	COG4975	Glucose uptake
ES969_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS02280	COG4549	nuclear export factor GLE1
ES969_RS02285	COG1276	copper resistance
ES969_RS02285	COG2372	response to copper ion
ES969_RS02290	COG1349	DNA-binding transcription factor activity
ES969_RS02300	COG2213	PTS system mannitol-specific
ES969_RS02305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS02310	COG0246	Mannitol dehydrogenase
ES969_RS02315	COG0473	3-isopropylmalate dehydrogenase activity
ES969_RS02320	COG0681	Belongs to the peptidase S26 family
ES969_RS02330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES969_RS02340	COG0561	phosphatase activity
ES969_RS02345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES969_RS02350	COG1914	H( )-stimulated, divalent metal cation uptake system
ES969_RS02355	COG4336	lyase activity
ES969_RS02360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES969_RS02365	COG1984	allophanate hydrolase subunit 2
ES969_RS02370	COG1414	Transcriptional regulator
ES969_RS02375	COG2755	lipolytic protein G-D-S-L family
ES969_RS02385	COG2329	Antibiotic biosynthesis monooxygenase
ES969_RS02390	COG0768	penicillin binding
ES969_RS02395	COG4989	oxidoreductase activity
ES969_RS02405	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS02410	COG2226	methyltransferase
ES969_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS02420	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS02430	COG3871	stress protein (general stress protein 26)
ES969_RS02440	COG2814	Major facilitator Superfamily
ES969_RS02445	COG1522	sequence-specific DNA binding
ES969_RS02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES969_RS02450	COG0551	DNA topoisomerase type I activity
ES969_RS02455	COG0494	nUDIX hydrolase
ES969_RS02460	COG0028	Belongs to the TPP enzyme family
ES969_RS02490	COG1914	H( )-stimulated, divalent metal cation uptake system
ES969_RS02495	COG2261	transglycosylase associated protein
ES969_RS02500	COG4876	unkown
ES969_RS02505	COG2217	Heavy metal translocating P-type atpase
ES969_RS02510	COG3729	General stress protein
ES969_RS02515	COG0662	Cupin 2, conserved barrel domain protein
ES969_RS02520	COG2329	Antibiotic biosynthesis monooxygenase
ES969_RS02525	COG3546	catalase activity
ES969_RS02530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES969_RS02535	COG3290	protein histidine kinase activity
ES969_RS02540	COG4565	transcriptional regulatory protein
ES969_RS02545	COG1301	dicarboxylic acid transport
ES969_RS02550	COG0628	permease
ES969_RS02555	COG1131	(ABC) transporter
ES969_RS02560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_RS02570	COG1960	acyl-CoA dehydrogenase activity
ES969_RS02585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_RS02590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS02595	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES969_RS02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES969_RS02610	COG0513	Belongs to the DEAD box helicase family
ES969_RS02615	COG3402	PFAM membrane-flanked domain
ES969_RS02620	COG3428	Bacterial PH domain
ES969_RS02625	COG0705	Rhomboid family
ES969_RS02630	COG0736	holo-[acyl-carrier-protein] synthase activity
ES969_RS02635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES969_RS02640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES969_RS02645	COG0864	Transcriptional regulator
ES969_RS02650	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES969_RS02655	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS02660	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS02665	COG2172	sigma factor antagonist activity
ES969_RS02670	COG2208	phosphoserine phosphatase activity
ES969_RS02675	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS02680	COG2172	sigma factor antagonist activity
ES969_RS02685	COG1191	sigma factor activity
ES969_RS02690	COG2208	phosphoserine phosphatase activity
ES969_RS02695	COG2183	response to ionizing radiation
ES969_RS02705	COG3091	SprT-like family
ES969_RS02745	COG0582	viral genome integration into host DNA
ES969_RS02750	COG2856	Zn peptidase
ES969_RS02755	COG1396	sequence-specific DNA binding
ES969_RS02780	COG1674	ftsk spoiiie
ES969_RS02785	COG2946	Replication initiation factor
ES969_RS02815	COG0433	COG0433 Predicted ATPase
ES969_RS02825	COG5644	endopeptidase inhibitor activity
ES969_RS02830	COG0791	NLP P60 protein
ES969_RS02830	COG0741	lytic transglycosylase activity
ES969_RS02850	COG0457	Tetratricopeptide repeat
ES969_RS02870	COG0583	DNA-binding transcription factor activity
ES969_RS02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS02915	COG1476	TRANSCRIPTIONal
ES969_RS02940	COG0693	protein deglycase activity
ES969_RS02945	COG1278	Cold shock
ES969_RS02950	COG1329	Transcriptional regulator
ES969_RS02960	COG0697	spore germination
ES969_RS02965	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS02965	COG2207	Transcriptional regulator
ES969_RS02970	COG0697	spore germination
ES969_RS02975	COG3708	Transcriptional regulator
ES969_RS02975	COG2207	Transcriptional regulator
ES969_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS02995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES969_RS03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS03015	COG1309	transcriptional regulator
ES969_RS03020	COG0697	spore germination
ES969_RS03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS03030	COG2030	dehydratase
ES969_RS03035	COG3545	Serine hydrolase
ES969_RS03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS03050	COG0640	Transcriptional regulator
ES969_RS03055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES969_RS03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS03070	COG0697	spore germination
ES969_RS03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS03080	COG0076	glutamate decarboxylase activity
ES969_RS03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES969_RS03090	COG0640	Transcriptional regulator
ES969_RS03110	COG4585	Histidine kinase
ES969_RS03115	COG2197	response regulator
ES969_RS03120	COG2409	Drug exporters of the RND superfamily
ES969_RS03130	COG0596	Alpha beta hydrolase
ES969_RS03135	COG1811	Na channel or pump
ES969_RS03140	COG0789	Transcriptional regulator
ES969_RS03140	COG4978	Transcriptional regulator
ES969_RS03145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_RS03150	COG0778	Nitroreductase
ES969_RS03155	COG0346	lactoylglutathione lyase activity
ES969_RS03160	COG2259	Doxx family
ES969_RS03165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS03185	COG2323	membrane
ES969_RS03190	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_RS03205	COG1309	transcriptional regulator
ES969_RS03215	COG0456	acetyltransferase
ES969_RS03220	COG0488	(ABC) transporter
ES969_RS03225	COG1113	amino acid transport
ES969_RS03230	COG2318	DinB family
ES969_RS03235	COG1846	Transcriptional regulator
ES969_RS03240	COG1033	growth of symbiont in host cell
ES969_RS03240	COG2409	Drug exporters of the RND superfamily
ES969_RS03245	COG0778	Nitroreductase
ES969_RS03250	COG1846	Transcriptional regulator
ES969_RS03255	COG2814	Major facilitator Superfamily
ES969_RS03260	COG0730	response to heat
ES969_RS03265	COG1802	Transcriptional regulator
ES969_RS03270	COG1388	LysM domain
ES969_RS03270	COG3858	chitin binding
ES969_RS03275	COG1819	glycosyl
ES969_RS03285	COG1785	Belongs to the alkaline phosphatase family
ES969_RS03290	COG5646	InterPro IPR014922
ES969_RS03300	COG0454	-acetyltransferase
ES969_RS03305	COG1078	dGTPase activity
ES969_RS03310	COG1388	LysM domain
ES969_RS03315	COG2814	Major facilitator Superfamily
ES969_RS03320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_RS03325	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES969_RS03330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_RS03335	COG2723	6-phospho-beta-galactosidase activity
ES969_RS03340	COG2188	Transcriptional regulator
ES969_RS03345	COG1940	carbohydrate kinase activity
ES969_RS03350	COG1482	cell wall glycoprotein biosynthetic process
ES969_RS03355	COG4124	Belongs to the glycosyl hydrolase 26 family
ES969_RS03400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES969_RS03405	COG0802	atpase or kinase
ES969_RS03410	COG1214	PFAM Peptidase M22, glycoprotease
ES969_RS03415	COG0456	acetyltransferase
ES969_RS03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES969_RS03425	COG0488	(ABC) transporter
ES969_RS03430	COG0315	cyclic pyranopterin monophosphate synthase activity
ES969_RS03435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES969_RS03440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_RS03445	COG0805	protein transport
ES969_RS03455	COG1266	CAAX protease self-immunity
ES969_RS03465	COG0459	protein refolding
ES969_RS03480	COG0457	Tetratricopeptide repeat
ES969_RS03485	COG1063	alcohol dehydrogenase
ES969_RS03490	COG2211	Major facilitator Superfamily
ES969_RS03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_RS03505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES969_RS03510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES969_RS03515	COG4260	virion core protein, lumpy skin disease virus
ES969_RS03525	COG2814	Major facilitator Superfamily
ES969_RS03530	COG1063	alcohol dehydrogenase
ES969_RS03535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES969_RS03540	COG0823	Involved in the tonB-independent uptake of proteins
ES969_RS03560	COG2267	carboxylic ester hydrolase activity
ES969_RS03570	COG2132	Multicopper oxidase
ES969_RS03575	COG1113	amino acid transport
ES969_RS03585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_RS03590	COG0714	Associated with various cellular activities
ES969_RS03595	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES969_RS03600	COG1305	Transglutaminase-like
ES969_RS03605	COG0519	Catalyzes the synthesis of GMP from XMP
ES969_RS03605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES969_RS03620	COG2252	PERMEase
ES969_RS03625	COG3064	Membrane
ES969_RS03635	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES969_RS03645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES969_RS03650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES969_RS03655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES969_RS03660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES969_RS03665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES969_RS03670	COG0047	phosphoribosylformylglycinamidine synthase activity
ES969_RS03675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES969_RS03680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES969_RS03685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES969_RS03690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES969_RS03695	COG0138	bifunctional purine biosynthesis protein purh
ES969_RS03700	COG0151	Belongs to the GarS family
ES969_RS03705	COG1522	sequence-specific DNA binding
ES969_RS03710	COG0531	amino acid
ES969_RS03720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES969_RS03725	COG1470	cell adhesion involved in biofilm formation
ES969_RS03730	COG4496	protein, YerC YecD
ES969_RS03735	COG0069	glutamate synthase activity
ES969_RS03740	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES969_RS03745	COG0210	DNA helicase
ES969_RS03750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES969_RS03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_RS03765	COG1285	pathogenesis
ES969_RS03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_RS03775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES969_RS03780	COG0154	amidase activity
ES969_RS03785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES969_RS03790	COG1309	transcriptional regulator
ES969_RS03795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES969_RS03800	COG1597	lipid kinase activity
ES969_RS03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES969_RS03825	COG5444	nuclease activity
ES969_RS03835	COG3586	endonuclease activity
ES969_RS03845	COG0457	Tetratricopeptide repeat
ES969_RS03855	COG0217	transcriptional regulatory protein
ES969_RS03865	COG1309	transcriptional regulator
ES969_RS03870	COG3631	Ketosteroid isomerase-related protein
ES969_RS03875	COG0702	epimerase
ES969_RS03890	COG3546	catalase activity
ES969_RS03895	COG0454	-acetyltransferase
ES969_RS03905	COG5578	integral membrane protein
ES969_RS03910	COG2972	Histidine kinase
ES969_RS03915	COG4753	response regulator
ES969_RS03915	COG2207	Transcriptional regulator
ES969_RS03920	COG1653	transport
ES969_RS03925	COG1175	transmembrane transport
ES969_RS03940	COG3401	FG-GAP repeat protein
ES969_RS03945	COG2755	lipolytic protein G-D-S-L family
ES969_RS03960	COG1653	transport
ES969_RS03970	COG0395	ABC-type sugar transport system, permease component
ES969_RS03975	COG1486	melibiose metabolic process
ES969_RS03980	COG2323	membrane
ES969_RS03985	COG2329	Antibiotic biosynthesis monooxygenase
ES969_RS03990	COG0346	lactoylglutathione lyase activity
ES969_RS04005	COG5583	Uncharacterized small protein (DUF2292)
ES969_RS04010	COG0670	Belongs to the BI1 family
ES969_RS04015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES969_RS04020	COG1715	Restriction endonuclease
ES969_RS04030	COG2124	cytochrome p450
ES969_RS04030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_RS04035	COG1368	sulfuric ester hydrolase activity
ES969_RS04040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES969_RS04045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_RS04050	COG1442	glycosyl transferase family 8
ES969_RS04055	COG1216	Glycosyl transferase, family 2
ES969_RS04060	COG1442	glycosyl transferase family 8
ES969_RS04065	COG2223	nitrite transmembrane transporter activity
ES969_RS04070	COG1011	Hydrolase
ES969_RS04075	COG0531	amino acid
ES969_RS04080	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS04085	COG0840	transmembrane signaling receptor activity
ES969_RS04090	COG0488	(ABC) transporter
ES969_RS04100	COG0789	Transcriptional regulator
ES969_RS04105	COG2814	Major facilitator Superfamily
ES969_RS04125	COG0488	(ABC) transporter
ES969_RS04130	COG0513	Belongs to the DEAD box helicase family
ES969_RS04135	COG0456	acetyltransferase
ES969_RS04150	COG2130	NADP-dependent
ES969_RS04155	COG1120	ATPase activity
ES969_RS04160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS04165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS04170	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES969_RS04185	COG3866	Pectate lyase
ES969_RS04190	COG0471	metal ion transport
ES969_RS04195	COG3290	protein histidine kinase activity
ES969_RS04200	COG4565	transcriptional regulatory protein
ES969_RS04205	COG3181	Tripartite tricarboxylate transporter family receptor
ES969_RS04210	COG2851	Citrate transporter
ES969_RS04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS04220	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES969_RS04225	COG1254	Belongs to the acylphosphatase family
ES969_RS04230	COG2258	MOSC domain
ES969_RS04250	COG0024	Methionine aminopeptidase
ES969_RS04255	COG1263	PTS System
ES969_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS04260	COG1368	sulfuric ester hydrolase activity
ES969_RS04275	COG1115	amino acid carrier protein
ES969_RS04290	COG0697	spore germination
ES969_RS04295	COG1263	PTS System
ES969_RS04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS04300	COG0366	Alpha amylase catalytic
ES969_RS04305	COG2188	Transcriptional regulator
ES969_RS04310	COG0778	Nitroreductase
ES969_RS04315	COG0737	Belongs to the 5'-nucleotidase family
ES969_RS04320	COG0693	protein deglycase activity
ES969_RS04325	COG2814	Major facilitator Superfamily
ES969_RS04330	COG4840	Belongs to the UPF0435 family
ES969_RS04335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES969_RS04340	COG4980	gas vesicle protein
ES969_RS04345	COG1295	ribonuclease BN
ES969_RS04350	COG0477	Major facilitator Superfamily
ES969_RS04355	COG0387	Pfam Sodium calcium exchanger
ES969_RS04365	COG0668	transmembrane transport
ES969_RS04370	COG0535	radical SAM domain protein
ES969_RS04380	COG0726	polysaccharide deacetylase
ES969_RS04385	COG2084	Dehydrogenase
ES969_RS04390	COG0598	Magnesium transport protein CorA
ES969_RS04395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES969_RS04400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES969_RS04410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES969_RS04415	COG4637	Psort location Cytoplasmic, score
ES969_RS04425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_RS04430	COG0022	dehydrogenase e1 component
ES969_RS04435	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_RS04440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_RS04445	COG3284	Transcriptional regulator
ES969_RS04455	COG1742	UPF0060 membrane protein
ES969_RS04480	COG4842	Belongs to the WXG100 family
ES969_RS04485	COG1486	melibiose metabolic process
ES969_RS04490	COG1737	Transcriptional regulator
ES969_RS04495	COG1263	PTS System
ES969_RS04495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS04500	COG1132	(ABC) transporter
ES969_RS04505	COG1132	(ABC) transporter
ES969_RS04510	COG2259	Doxx family
ES969_RS04515	COG2514	catechol 2,3-dioxygenase activity
ES969_RS04520	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS04520	COG4977	sequence-specific DNA binding
ES969_RS04525	COG2814	Major facilitator Superfamily
ES969_RS04530	COG1082	Xylose isomerase domain protein TIM barrel
ES969_RS04540	COG4585	Histidine kinase
ES969_RS04545	COG2197	response regulator
ES969_RS04550	COG1131	(ABC) transporter
ES969_RS04555	COG0842	Transport permease protein
ES969_RS04555	COG1511	domain protein
ES969_RS04560	COG0842	Transport permease protein
ES969_RS04565	COG1695	Transcriptional regulator
ES969_RS04570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES969_RS04575	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES969_RS04580	COG1309	transcriptional regulator
ES969_RS04585	COG2814	Major facilitator Superfamily
ES969_RS04590	COG2318	DinB family
ES969_RS04595	COG2814	Major facilitator Superfamily
ES969_RS04600	COG1846	Transcriptional regulator
ES969_RS04605	COG0392	lysyltransferase activity
ES969_RS04605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES969_RS04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS04620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS04630	COG0778	Nitroreductase
ES969_RS04645	COG1090	epimerase
ES969_RS04650	COG2137	regulation of response to DNA damage stimulus
ES969_RS04660	COG2814	Major facilitator Superfamily
ES969_RS04675	COG3103	Sh3 type 3 domain protein
ES969_RS04680	COG5658	integral membrane protein
ES969_RS04685	COG0596	Alpha beta hydrolase
ES969_RS04690	COG0463	Glycosyl transferase, family 2
ES969_RS04695	COG4485	Bacterial membrane protein, YfhO
ES969_RS04700	COG1988	membrane-bound metal-dependent
ES969_RS04705	COG1194	a g-specific adenine glycosylase
ES969_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS04730	COG3557	Belongs to the UPF0374 family
ES969_RS04735	COG1132	(ABC) transporter
ES969_RS04740	COG4129	membrane
ES969_RS04745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES969_RS04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES969_RS04755	COG0735	belongs to the Fur family
ES969_RS04865	COG4326	sporulation control protein
ES969_RS04875	COG5577	PFAM Coat F domain
ES969_RS04880	COG3340	Belongs to the peptidase S51 family
ES969_RS04885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES969_RS04900	COG0753	catalase activity
ES969_RS04905	COG1116	anion transmembrane transporter activity
ES969_RS04915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES969_RS04920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_RS04930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES969_RS04940	COG1476	TRANSCRIPTIONal
ES969_RS04950	COG3382	B3 4 domain protein
ES969_RS04955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES969_RS04965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES969_RS04970	COG0789	Transcriptional regulator
ES969_RS04975	COG1664	Polymer-forming cytoskeletal
ES969_RS04980	COG1664	Polymer-forming cytoskeletal
ES969_RS04985	COG2766	serine protein kinase
ES969_RS04990	COG2718	Belongs to the UPF0229 family
ES969_RS04995	COG1846	Transcriptional regulator
ES969_RS05000	COG1566	PFAM secretion protein HlyD family protein
ES969_RS05005	COG2814	Major facilitator Superfamily
ES969_RS05010	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES969_RS05030	COG1725	Transcriptional regulator
ES969_RS05035	COG1131	(ABC) transporter
ES969_RS05040	COG1131	(ABC) transporter
ES969_RS05045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_RS05050	COG1278	Cold shock
ES969_RS05060	COG1464	Belongs to the NlpA lipoprotein family
ES969_RS05070	COG1823	symporter activity
ES969_RS05075	COG5444	nuclease activity
ES969_RS05100	COG0582	viral genome integration into host DNA
ES969_RS05105	COG2946	Replication initiation factor
ES969_RS05155	COG5644	endopeptidase inhibitor activity
ES969_RS05160	COG0741	lytic transglycosylase activity
ES969_RS05160	COG0791	NLP P60 protein
ES969_RS05180	COG0457	Tetratricopeptide repeat
ES969_RS05205	COG1525	nuclease
ES969_RS05205	COG0737	Belongs to the 5'-nucleotidase family
ES969_RS05205	COG4085	toxin activity
ES969_RS05210	COG3764	Sortase (surface protein transpeptidase)
ES969_RS05215	COG0564	pseudouridine synthase activity
ES969_RS05225	COG0517	IMP dehydrogenase activity
ES969_RS05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES969_RS05235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES969_RS05235	COG3153	acetyltransferase
ES969_RS05245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_RS05250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES969_RS05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES969_RS05260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES969_RS05265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES969_RS05270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES969_RS05275	COG4585	Histidine kinase
ES969_RS05275	COG2203	Gaf domain
ES969_RS05280	COG2197	response regulator
ES969_RS05285	COG0431	NADPH-dependent FMN reductase
ES969_RS05300	COG1388	LysM domain
ES969_RS05300	COG0791	NLP P60 protein
ES969_RS05305	COG1959	2 iron, 2 sulfur cluster binding
ES969_RS05310	COG0668	transmembrane transport
ES969_RS05315	COG2719	SpoVR family
ES969_RS05320	COG1785	Belongs to the alkaline phosphatase family
ES969_RS05325	COG1388	LysM domain
ES969_RS05325	COG0791	NLP P60 protein
ES969_RS05330	COG0583	DNA-binding transcription factor activity
ES969_RS05335	COG0372	Belongs to the citrate synthase family
ES969_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS05350	COG0733	neurotransmitter:sodium symporter activity
ES969_RS05355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS05360	COG0456	acetyltransferase
ES969_RS05375	COG1595	DNA-templated transcription, initiation
ES969_RS05380	COG0667	Aldo Keto reductase
ES969_RS05385	COG0204	Acyl-transferase
ES969_RS05390	COG1253	flavin adenine dinucleotide binding
ES969_RS05395	COG0789	Transcriptional regulator
ES969_RS05400	COG0436	Aminotransferase
ES969_RS05405	COG1253	flavin adenine dinucleotide binding
ES969_RS05410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES969_RS05415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES969_RS05420	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_RS05430	COG0668	transmembrane transport
ES969_RS05435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES969_RS05440	COG0726	polysaccharide deacetylase
ES969_RS05445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_RS05450	COG1757	Na H antiporter
ES969_RS05455	COG0589	response to stress
ES969_RS05465	COG1132	(ABC) transporter
ES969_RS05470	COG1132	(ABC) transporter
ES969_RS05475	COG0702	epimerase
ES969_RS05495	COG0189	ligase activity
ES969_RS05500	COG0189	ligase activity
ES969_RS05505	COG4399	Belongs to the UPF0754 family
ES969_RS05510	COG3679	Belongs to the UPF0342 family
ES969_RS05515	COG4335	DNA alkylation repair
ES969_RS05520	COG0561	phosphatase activity
ES969_RS05525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES969_RS05530	COG0475	glutathione-regulated potassium exporter activity
ES969_RS05535	COG0490	domain, Protein
ES969_RS05545	COG1024	Enoyl-CoA hydratase
ES969_RS05555	COG4152	abc transporter atp-binding protein
ES969_RS05560	COG1668	transmembrane transport
ES969_RS05565	COG0420	3'-5' exonuclease activity
ES969_RS05570	COG4717	serine-type aminopeptidase activity
ES969_RS05575	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES969_RS05585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES969_RS05615	COG1846	Transcriptional regulator
ES969_RS05620	COG4980	gas vesicle protein
ES969_RS05635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES969_RS05640	COG0537	adenosine 5'-monophosphoramidase activity
ES969_RS05645	COG1131	(ABC) transporter
ES969_RS05650	COG4473	ABC transporter
ES969_RS05660	COG1473	amidohydrolase
ES969_RS05665	COG3069	C4-dicarboxylate transmembrane transporter activity
ES969_RS05675	COG2329	Antibiotic biosynthesis monooxygenase
ES969_RS05680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_RS05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES969_RS05690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ES969_RS05695	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ES969_RS05700	COG1309	transcriptional regulator
ES969_RS05705	COG1511	domain protein
ES969_RS05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_RS05715	COG4377	Putative membrane peptidase family (DUF2324)
ES969_RS05725	COG1363	Peptidase, m42
ES969_RS05730	COG4405	Protein conserved in bacteria
ES969_RS05735	COG1301	dicarboxylic acid transport
ES969_RS05745	COG1234	tRNA 3'-trailer cleavage
ES969_RS05750	COG0095	Lipoate-protein ligase
ES969_RS05755	COG0702	epimerase
ES969_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS05770	COG0501	Belongs to the peptidase M48B family
ES969_RS05775	COG1404	Belongs to the peptidase S8 family
ES969_RS05780	COG0456	acetyltransferase
ES969_RS05785	COG0604	alcohol dehydrogenase
ES969_RS05790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES969_RS05795	COG0406	alpha-ribazole phosphatase activity
ES969_RS05800	COG0183	Belongs to the thiolase family
ES969_RS05805	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS05810	COG1268	BioY protein
ES969_RS05815	COG0840	transmembrane signaling receptor activity
ES969_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS05835	COG4903	ComK protein
ES969_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS05850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_RS05865	COG0398	Pfam SNARE associated Golgi protein
ES969_RS05870	COG0681	Belongs to the peptidase S26 family
ES969_RS05875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES969_RS05880	COG1846	Transcriptional regulator
ES969_RS05890	COG0738	Major facilitator superfamily
ES969_RS05895	COG0673	inositol 2-dehydrogenase activity
ES969_RS05900	COG0561	phosphatase activity
ES969_RS05905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_RS05910	COG1609	Transcriptional regulator
ES969_RS05915	COG3180	Ammonia monooxygenase
ES969_RS05920	COG2814	Major facilitator Superfamily
ES969_RS05920	COG0477	Major facilitator Superfamily
ES969_RS05925	COG4533	DNA binding
ES969_RS05935	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES969_RS05940	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES969_RS05945	COG1074	ATP-dependent DNA helicase activity
ES969_RS05950	COG0420	3'-5' exonuclease activity
ES969_RS05955	COG0419	ATPase involved in DNA repair
ES969_RS05960	COG1403	HNH endonuclease
ES969_RS06000	COG5337	Spore coat protein CotH
ES969_RS06005	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES969_RS06015	COG1404	Belongs to the peptidase S8 family
ES969_RS06025	COG0367	asparagine synthase
ES969_RS06030	COG1562	ergosterol biosynthetic process
ES969_RS06035	COG0534	Mate efflux family protein
ES969_RS06040	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS06040	COG2207	Transcriptional regulator
ES969_RS06045	COG1609	Transcriptional regulator
ES969_RS06050	COG0673	inositol 2-dehydrogenase activity
ES969_RS06055	COG2318	DinB family
ES969_RS06060	COG1279	arginine transmembrane transporter activity
ES969_RS06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_RS06070	COG1357	PFAM Pentapeptide repeats (8 copies)
ES969_RS06075	COG2267	carboxylic ester hydrolase activity
ES969_RS06085	COG2153	protein acetylation
ES969_RS06090	COG0646	methionine synthase
ES969_RS06090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES969_RS06095	COG1666	GTP binding
ES969_RS06100	COG2996	Protein conserved in bacteria
ES969_RS06110	COG1307	EDD domain protein, DegV family
ES969_RS06115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS06130	COG0561	phosphatase activity
ES969_RS06135	COG1073	alpha beta
ES969_RS06140	COG2151	metal-sulfur cluster biosynthetic enzyme
ES969_RS06150	COG0277	FAD linked oxidase domain protein
ES969_RS06155	COG2271	Major facilitator Superfamily
ES969_RS06160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES969_RS06165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ES969_RS06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES969_RS06180	COG0505	Belongs to the CarA family
ES969_RS06185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES969_RS06190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES969_RS06210	COG2267	carboxylic ester hydrolase activity
ES969_RS06220	COG1744	ABC transporter substrate-binding protein PnrA-like
ES969_RS06235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_RS06240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES969_RS06245	COG5504	Zn-dependent protease
ES969_RS06250	COG0444	Belongs to the ABC transporter superfamily
ES969_RS06255	COG4608	Belongs to the ABC transporter superfamily
ES969_RS06265	COG0601	transmembrane transport
ES969_RS06270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_RS06280	COG0180	Tryptophanyl-tRNA synthetase
ES969_RS06285	COG4166	transmembrane transport
ES969_RS06290	COG0601	transmembrane transport
ES969_RS06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_RS06300	COG0444	Belongs to the ABC transporter superfamily
ES969_RS06305	COG4608	Belongs to the ABC transporter superfamily
ES969_RS06310	COG2814	Major facilitator Superfamily
ES969_RS06315	COG0456	acetyltransferase
ES969_RS06320	COG1393	Belongs to the ArsC family
ES969_RS06325	COG0861	Integral membrane protein TerC family
ES969_RS06335	COG4862	establishment of competence for transformation
ES969_RS06345	COG4469	Competence protein
ES969_RS06350	COG1164	Oligoendopeptidase f
ES969_RS06365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES969_RS06370	COG2346	COG2346, Truncated hemoglobins
ES969_RS06375	COG0741	lytic transglycosylase activity
ES969_RS06380	COG4116	CYTH
ES969_RS06390	COG2357	RelA SpoT domain protein
ES969_RS06395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES969_RS06400	COG0564	pseudouridine synthase activity
ES969_RS06405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES969_RS06410	COG0475	glutathione-regulated potassium exporter activity
ES969_RS06410	COG0569	domain protein
ES969_RS06415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES969_RS06420	COG0352	thiamine-phosphate diphosphorylase activity
ES969_RS06425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES969_RS06430	COG2104	thiamine diphosphate biosynthetic process
ES969_RS06435	COG2022	thiamine diphosphate biosynthetic process
ES969_RS06440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_RS06445	COG0351	phosphomethylpyrimidine kinase
ES969_RS06450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES969_RS06505	COG0210	DNA helicase
ES969_RS06515	COG2153	protein acetylation
ES969_RS06520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES969_RS06525	COG2382	esterase
ES969_RS06530	COG0626	cystathionine gamma-synthase activity
ES969_RS06535	COG0626	cystathionine gamma-synthase activity
ES969_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS06545	COG5505	Protein of unknown function (DUF819)
ES969_RS06580	COG1396	sequence-specific DNA binding
ES969_RS06640	COG0457	Tetratricopeptide repeat
ES969_RS06645	COG5444	nuclease activity
ES969_RS06660	COG3328	transposase activity
ES969_RS06665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS06675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES969_RS06695	COG0109	protoheme IX farnesyltransferase activity
ES969_RS06705	COG0726	polysaccharide deacetylase
ES969_RS06720	COG5504	Zn-dependent protease
ES969_RS06725	COG2205	protein histidine kinase activity
ES969_RS06740	COG2427	Protein of unknown function (DUF1641)
ES969_RS06750	COG1051	belongs to the nudix hydrolase family
ES969_RS06760	COG2124	cytochrome p450
ES969_RS06765	COG1819	glycosyl
ES969_RS06775	COG1587	Uroporphyrinogen-III synthase
ES969_RS06780	COG0390	transport system, permease component
ES969_RS06785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_RS06790	COG0697	spore germination
ES969_RS06805	COG1252	NADH dehydrogenase
ES969_RS06810	COG1904	glucuronate isomerase
ES969_RS06820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES969_RS06825	COG1063	alcohol dehydrogenase
ES969_RS06830	COG1312	Catalyzes the dehydration of D-mannonate
ES969_RS06835	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS06840	COG2271	Major facilitator Superfamily
ES969_RS06845	COG1609	Transcriptional regulator
ES969_RS06850	COG0246	Mannitol dehydrogenase
ES969_RS06855	COG2721	sulfolactate sulfo-lyase activity
ES969_RS06860	COG0730	response to heat
ES969_RS06865	COG2318	DinB family
ES969_RS06885	COG0457	Tetratricopeptide repeat
ES969_RS06900	COG1388	LysM domain
ES969_RS06900	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS06900	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_RS06910	COG4195	phage-related replication protein
ES969_RS06915	COG3546	catalase activity
ES969_RS06920	COG2856	Zn peptidase
ES969_RS06925	COG1396	sequence-specific DNA binding
ES969_RS06935	COG1522	sequence-specific DNA binding
ES969_RS06940	COG1484	DNA-dependent DNA replication
ES969_RS06960	COG1595	DNA-templated transcription, initiation
ES969_RS06965	COG5484	DNA packaging
ES969_RS06965	COG3728	DNA packaging
ES969_RS06970	COG1783	phage Terminase large subunit
ES969_RS06975	COG5518	Phage portal protein
ES969_RS06980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES969_RS06985	COG4653	Phage capsid family
ES969_RS07035	COG5412	phage tail tape measure protein
ES969_RS07035	COG5412	phage tail tape measure protein
ES969_RS07035	COG3953	SLT domain
ES969_RS07035	COG3953	SLT domain
ES969_RS07035	COG5412	phage tail tape measure protein
ES969_RS07035	COG3953	SLT domain
ES969_RS07040	COG1652	LysM domain
ES969_RS07045	COG4193	domain, Protein
ES969_RS07055	COG3628	GPW Gp25 family protein
ES969_RS07060	COG3299	homolog of phage Mu protein gp47
ES969_RS07065	COG3778	Protein conserved in bacteria
ES969_RS07105	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS07105	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_RS07125	COG0306	phosphate transporter
ES969_RS07130	COG1392	Phosphate transport regulator
ES969_RS07135	COG0531	amino acid
ES969_RS07140	COG0346	lactoylglutathione lyase activity
ES969_RS07145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES969_RS07150	COG0463	Glycosyl transferase, family 2
ES969_RS07155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_RS07160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_RS07165	COG2362	D-Aminopeptidase
ES969_RS07170	COG0601	transmembrane transport
ES969_RS07175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_RS07180	COG0444	Belongs to the ABC transporter superfamily
ES969_RS07185	COG4166	transmembrane transport
ES969_RS07190	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES969_RS07195	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_RS07200	COG0791	NLP P60 protein
ES969_RS07205	COG4608	Belongs to the ABC transporter superfamily
ES969_RS07210	COG2706	6-phosphogluconolactonase activity
ES969_RS07220	COG1607	acyl-coa hydrolase
ES969_RS07225	COG1017	nitric oxide dioxygenase activity
ES969_RS07225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES969_RS07235	COG2323	membrane
ES969_RS07240	COG2318	DinB family
ES969_RS07250	COG2076	Multidrug Resistance protein
ES969_RS07255	COG2076	Multidrug Resistance protein
ES969_RS07260	COG0788	formyltetrahydrofolate deformylase activity
ES969_RS07265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES969_RS07270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES969_RS07275	COG1764	response to oxidative stress
ES969_RS07280	COG1846	Transcriptional regulator
ES969_RS07285	COG1764	response to oxidative stress
ES969_RS07295	COG0590	tRNA wobble adenosine to inosine editing
ES969_RS07300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_RS07305	COG1404	Belongs to the peptidase S8 family
ES969_RS07310	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS07315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES969_RS07320	COG1122	ATPase activity
ES969_RS07325	COG4721	ABC-type cobalt transport system, permease component
ES969_RS07335	COG0745	RESPONSE REGULATOR receiver
ES969_RS07340	COG5002	protein histidine kinase activity
ES969_RS07340	COG3850	Histidine kinase
ES969_RS07350	COG3212	peptidase
ES969_RS07365	COG2239	Acts as a magnesium transporter
ES969_RS07370	COG0789	Transcriptional regulator
ES969_RS07385	COG1846	Transcriptional regulator
ES969_RS07395	COG0726	polysaccharide deacetylase
ES969_RS07400	COG1408	metallophosphoesterase
ES969_RS07410	COG0463	Glycosyl transferase, family 2
ES969_RS07415	COG1793	dna ligase
ES969_RS07415	COG3285	dna ligase
ES969_RS07420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES969_RS07425	COG3300	MHYT domain
ES969_RS07425	COG5001	Diguanylate cyclase
ES969_RS07430	COG0586	Pfam SNARE associated Golgi protein
ES969_RS07435	COG0861	Integral membrane protein TerC family
ES969_RS07440	COG1191	sigma factor activity
ES969_RS07460	COG0501	Belongs to the peptidase M48B family
ES969_RS07465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES969_RS07480	COG3594	Acyltransferase
ES969_RS07485	COG5002	protein histidine kinase activity
ES969_RS07490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES969_RS07500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES969_RS07505	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES969_RS07510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES969_RS07515	COG0436	Aminotransferase
ES969_RS07520	COG1850	ribulose-bisphosphate carboxylase activity
ES969_RS07525	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES969_RS07530	COG0235	Class ii aldolase
ES969_RS07535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES969_RS07540	COG3339	Conserved Protein
ES969_RS07555	COG3852	Histidine kinase
ES969_RS07565	COG1846	Transcriptional regulator
ES969_RS07570	COG1360	Flagellar Motor Protein
ES969_RS07575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES969_RS07585	COG0542	response to heat
ES969_RS07590	COG3949	Membrane
ES969_RS07595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES969_RS07600	COG0720	synthase
ES969_RS07605	COG0602	queuosine metabolic process
ES969_RS07610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES969_RS07620	COG4873	Protein conserved in bacteria
ES969_RS07630	COG3773	Cell wall hydrolase
ES969_RS07635	COG2244	polysaccharide biosynthetic process
ES969_RS07640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS07645	COG2217	Heavy metal translocating P-type atpase
ES969_RS07655	COG0006	proline dipeptidase activity
ES969_RS07660	COG1609	Transcriptional regulator
ES969_RS07665	COG3711	transcriptional antiterminator
ES969_RS07670	COG2190	(PTS) system
ES969_RS07670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS07670	COG1263	PTS System
ES969_RS07675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS07680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES969_RS07690	COG1533	DNA photolyase activity
ES969_RS07695	COG0456	acetyltransferase
ES969_RS07700	COG0840	transmembrane signaling receptor activity
ES969_RS07705	COG2084	Dehydrogenase
ES969_RS07710	COG3328	transposase activity
ES969_RS07720	COG2340	Cysteine-rich secretory protein family
ES969_RS07725	COG0768	penicillin binding
ES969_RS07730	COG4191	Histidine kinase
ES969_RS07735	COG0436	Aminotransferase
ES969_RS07745	COG0784	Response regulator, receiver
ES969_RS07745	COG0835	chemotaxis
ES969_RS07755	COG2814	Major facilitator Superfamily
ES969_RS07760	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_RS07765	COG1408	metallophosphoesterase
ES969_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS07775	COG2200	EAL domain
ES969_RS07780	COG4703	Protein of unknown function (DUF1797)
ES969_RS07785	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES969_RS07795	COG0517	IMP dehydrogenase activity
ES969_RS07800	COG0583	DNA-binding transcription factor activity
ES969_RS07805	COG0716	FMN binding
ES969_RS07815	COG0716	FMN binding
ES969_RS07820	COG2171	N-acyltransferase activity
ES969_RS07825	COG1473	amidohydrolase
ES969_RS07835	COG0668	transmembrane transport
ES969_RS07840	COG0450	alkyl hydroperoxide reductase
ES969_RS07845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS07865	COG0746	molybdenum cofactor guanylyltransferase activity
ES969_RS07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_RS07875	COG0303	'Molybdopterin
ES969_RS07880	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES969_RS07885	COG0314	molybdopterin synthase activity
ES969_RS07890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES969_RS07895	COG1132	(ABC) transporter
ES969_RS07900	COG1132	(ABC) transporter
ES969_RS07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES969_RS07915	COG1136	(ABC) transporter
ES969_RS07920	COG0577	efflux transmembrane transporter activity
ES969_RS07925	COG1349	DNA-binding transcription factor activity
ES969_RS07930	COG1105	Belongs to the carbohydrate kinase PfkB family
ES969_RS07935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES969_RS07935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES969_RS07935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS07940	COG0681	Belongs to the peptidase S26 family
ES969_RS07950	COG0488	(ABC) transporter
ES969_RS07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES969_RS07960	COG2309	aminopeptidase activity
ES969_RS07970	COG1077	Cell shape determining protein MreB Mrl
ES969_RS07975	COG2002	toxin-antitoxin pair type II binding
ES969_RS07980	COG3852	Histidine kinase
ES969_RS07985	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES969_RS07985	COG2105	PFAM AIG2 family protein
ES969_RS07990	COG0569	domain protein
ES969_RS07995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES969_RS08000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES969_RS08005	COG5503	Protein of unknown function (DUF1447)
ES969_RS08010	COG0561	phosphatase activity
ES969_RS08015	COG0242	peptide deformylase activity
ES969_RS08025	COG0497	DNA recombination
ES969_RS08030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_RS08035	COG0022	dehydrogenase e1 component
ES969_RS08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_RS08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_RS08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS08060	COG1982	Orn Lys Arg decarboxylase major
ES969_RS08065	COG4476	Belongs to the UPF0223 family
ES969_RS08070	COG4493	Belongs to the UPF0637 family
ES969_RS08080	COG0483	inositol monophosphate 1-phosphatase activity
ES969_RS08090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES969_RS08130	COG1217	gtp-binding protein TYPA
ES969_RS08140	COG4896	Protein conserved in bacteria
ES969_RS08150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES969_RS08155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES969_RS08160	COG2066	Belongs to the glutaminase family
ES969_RS08165	COG4838	Belongs to the UPF0358 family
ES969_RS08170	COG0772	Belongs to the SEDS family
ES969_RS08175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES969_RS08185	COG1612	heme a metabolic process
ES969_RS08190	COG0109	protoheme IX farnesyltransferase activity
ES969_RS08195	COG2010	Cytochrome c
ES969_RS08195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES969_RS08200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES969_RS08205	COG1845	cytochrome c oxidase, subunit III
ES969_RS08210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES969_RS08215	COG3336	cytochrome c oxidase
ES969_RS08225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES969_RS08230	COG2340	Cysteine-rich secretory protein family
ES969_RS08245	COG3679	Belongs to the UPF0342 family
ES969_RS08250	COG4471	UPF0298 protein
ES969_RS08255	COG0742	ribosomal rna small subunit methyltransferase
ES969_RS08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES969_RS08265	COG3314	Sporulation integral membrane protein YlbJ
ES969_RS08270	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES969_RS08275	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES969_RS08280	COG1323	Belongs to the UPF0348 family
ES969_RS08290	COG1399	metal-binding, possibly nucleic acid-binding protein
ES969_RS08305	COG0454	-acetyltransferase
ES969_RS08310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES969_RS08315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES969_RS08320	COG2001	Belongs to the MraZ family
ES969_RS08325	COG0275	rRNA processing
ES969_RS08330	COG4839	cell division protein FtsL
ES969_RS08335	COG0768	penicillin binding
ES969_RS08340	COG0768	penicillin binding
ES969_RS08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES969_RS08350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES969_RS08355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES969_RS08360	COG0772	Belongs to the SEDS family
ES969_RS08365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES969_RS08370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES969_RS08375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES969_RS08380	COG3879	Bacterial protein of unknown function (DUF881)
ES969_RS08385	COG3879	Bacterial protein of unknown function (DUF881)
ES969_RS08390	COG3856	small basic protein
ES969_RS08395	COG0849	cell division
ES969_RS08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES969_RS08405	COG1404	Belongs to the peptidase S8 family
ES969_RS08405	COG4412	M6 family metalloprotease domain protein
ES969_RS08415	COG1191	sigma factor activity
ES969_RS08420	COG1191	sigma factor activity
ES969_RS08425	COG1119	ATPase activity
ES969_RS08430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_RS08435	COG1873	PFAM PRC-barrel domain
ES969_RS08440	COG1496	oxidoreductase activity
ES969_RS08445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES969_RS08450	COG1799	cell septum assembly
ES969_RS08455	COG0762	integral membrane protein
ES969_RS08460	COG2302	S4 RNA-binding domain
ES969_RS08465	COG3599	regulation of cell shape
ES969_RS08470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES969_RS08475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_RS08480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES969_RS08485	COG0564	pseudouridine synthase activity
ES969_RS08490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES969_RS08495	COG2233	PERMEase
ES969_RS08500	COG0540	Belongs to the ATCase OTCase family
ES969_RS08505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES969_RS08510	COG0505	Belongs to the CarA family
ES969_RS08515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES969_RS08520	COG0543	2 iron, 2 sulfur cluster binding
ES969_RS08525	COG0167	dihydroorotate dehydrogenase activity
ES969_RS08530	COG0284	orotidine-5'-phosphate decarboxylase activity
ES969_RS08535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES969_RS08540	COG0175	sulfate reduction
ES969_RS08545	COG0306	phosphate transporter
ES969_RS08550	COG2046	Belongs to the sulfate adenylyltransferase family
ES969_RS08555	COG0529	Catalyzes the synthesis of activated sulfate
ES969_RS08560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES969_RS08565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES969_RS08570	COG1648	precorrin-2 dehydrogenase activity
ES969_RS08580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES969_RS08585	COG1561	YicC-like family, N-terminal region
ES969_RS08595	COG0194	GDP metabolic process
ES969_RS08600	COG1758	RNA polymerase activity
ES969_RS08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES969_RS08610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES969_RS08615	COG0242	peptide deformylase activity
ES969_RS08620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES969_RS08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES969_RS08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES969_RS08630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES969_RS08635	COG0631	protein serine/threonine phosphatase activity
ES969_RS08640	COG2815	serine threonine protein kinase
ES969_RS08640	COG0515	serine threonine protein kinase
ES969_RS08645	COG1162	GTPase activity
ES969_RS08650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES969_RS08655	COG1564	THIamine pyrophosphokinase
ES969_RS08665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES969_RS08670	COG1302	Protein conserved in bacteria
ES969_RS08675	COG1461	Dihydroxyacetone kinase
ES969_RS08680	COG1760	l-serine dehydratase
ES969_RS08685	COG1760	l-serine dehydratase
ES969_RS08690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES969_RS08695	COG2050	protein possibly involved in aromatic compounds catabolism
ES969_RS08695	COG1349	DNA-binding transcription factor activity
ES969_RS08700	COG0416	fatty acid biosynthetic process
ES969_RS08705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES969_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS08720	COG0571	ribonuclease III activity
ES969_RS08725	COG1196	nuclear chromosome segregation
ES969_RS08730	COG0552	protein localization to endoplasmic reticulum
ES969_RS08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES969_RS08745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES969_RS08750	COG0228	four-way junction DNA binding
ES969_RS08755	COG1837	Belongs to the UPF0109 family
ES969_RS08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES969_RS08770	COG0336	Belongs to the RNA methyltransferase TrmD family
ES969_RS08775	COG0335	large ribosomal subunit rRNA binding
ES969_RS08780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES969_RS08785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES969_RS08795	COG2257	FlhB HrpN YscU SpaS Family
ES969_RS08800	COG0045	succinate-CoA ligase (ADP-forming) activity
ES969_RS08805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES969_RS08810	COG0758	DNA mediated transformation
ES969_RS08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES969_RS08820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES969_RS08825	COG4974	Belongs to the 'phage' integrase family
ES969_RS08830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES969_RS08835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES969_RS08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES969_RS08845	COG1815	bacterial-type flagellum-dependent cell motility
ES969_RS08850	COG1558	bacterial-type flagellum-dependent cell motility
ES969_RS08855	COG1677	Flagellar hook-basal body complex protein FliE
ES969_RS08860	COG1766	The M ring may be actively involved in energy transduction
ES969_RS08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_RS08870	COG1317	bacterial-type flagellum organization
ES969_RS08875	COG1157	protein secretion by the type III secretion system
ES969_RS08880	COG2882	bacterial-type flagellum organization
ES969_RS08885	COG3334	PFAM MgtE intracellular
ES969_RS08890	COG3144	bacterial-type flagellum assembly
ES969_RS08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES969_RS08900	COG4786	Flagellar basal body rod
ES969_RS08905	COG1582	Flagellar protein (FlbD)
ES969_RS08910	COG1580	Controls the rotational direction of flagella during chemotaxis
ES969_RS08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_RS08920	COG1776	CheC inhibitor of MCP methylation
ES969_RS08920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_RS08925	COG2201	protein-glutamate methylesterase activity
ES969_RS08930	COG3190	flagellar
ES969_RS08935	COG1338	Plays a role in the flagellum-specific transport system
ES969_RS08940	COG1987	bacterial-type flagellum assembly
ES969_RS08945	COG1684	flagellar biosynthetic protein fliR
ES969_RS08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES969_RS08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES969_RS08960	COG1419	protein localization to endoplasmic reticulum
ES969_RS08965	COG0455	bacterial-type flagellum organization
ES969_RS08970	COG2201	protein-glutamate methylesterase activity
ES969_RS08975	COG0643	Histidine kinase
ES969_RS08975	COG2198	Histidine kinase
ES969_RS08980	COG0835	chemotaxis
ES969_RS08985	COG1776	CheC inhibitor of MCP methylation
ES969_RS08990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES969_RS08995	COG1191	sigma factor activity
ES969_RS09005	COG0052	Belongs to the universal ribosomal protein uS2 family
ES969_RS09010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES969_RS09015	COG0528	UMP kinase activity
ES969_RS09020	COG0233	cytoplasmic translational termination
ES969_RS09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES969_RS09030	COG4589	Belongs to the CDS family
ES969_RS09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES969_RS09040	COG0750	zinc metalloprotease
ES969_RS09045	COG0442	prolyl-tRNA aminoacylation
ES969_RS09050	COG2176	DNA-directed DNA polymerase activity
ES969_RS09055	COG0779	Required for maturation of 30S ribosomal subunits
ES969_RS09060	COG0195	Participates in both transcription termination and antitermination
ES969_RS09065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES969_RS09070	COG1358	cellular component organization or biogenesis
ES969_RS09075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES969_RS09080	COG1550	Protein conserved in bacteria
ES969_RS09085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES969_RS09090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES969_RS09095	COG0196	riboflavin kinase activity
ES969_RS09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES969_RS09105	COG1185	polyribonucleotide nucleotidyltransferase activity
ES969_RS09110	COG0726	polysaccharide deacetylase
ES969_RS09115	COG0612	Peptidase, M16
ES969_RS09120	COG1873	PFAM PRC-barrel domain
ES969_RS09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES969_RS09130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES969_RS09135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES969_RS09140	COG0527	aspartate kinase activity
ES969_RS09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES969_RS09150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES969_RS09155	COG0740	serine-type endopeptidase activity
ES969_RS09165	COG1674	ftsk spoiiie
ES969_RS09165	COG4980	gas vesicle protein
ES969_RS09170	COG2188	Transcriptional regulator
ES969_RS09175	COG2814	Major facilitator Superfamily
ES969_RS09180	COG0612	Peptidase, M16
ES969_RS09185	COG0612	Peptidase, M16
ES969_RS09190	COG0300	oxidoreductase activity
ES969_RS09205	COG1426	Protein conserved in bacteria
ES969_RS09210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES969_RS09215	COG1058	Belongs to the CinA family
ES969_RS09215	COG1546	Belongs to the CinA family
ES969_RS09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES969_RS09225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES969_RS09230	COG1418	mRNA catabolic process
ES969_RS09235	COG1692	metallophosphoesterase
ES969_RS09240	COG2359	stage V sporulation protein S
ES969_RS09245	COG1063	alcohol dehydrogenase
ES969_RS09250	COG0156	8-amino-7-oxononanoate synthase activity
ES969_RS09255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES969_RS09260	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES969_RS09270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES969_RS09275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES969_RS09345	COG3328	transposase activity
ES969_RS09365	COG3226	Transcriptional regulator
ES969_RS09375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS09380	COG1404	Belongs to the peptidase S8 family
ES969_RS09390	COG4195	phage-related replication protein
ES969_RS09395	COG1764	response to oxidative stress
ES969_RS09400	COG2076	Multidrug Resistance protein
ES969_RS09405	COG2076	Multidrug Resistance protein
ES969_RS09420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES969_RS09425	COG1923	regulation of RNA biosynthetic process
ES969_RS09440	COG1780	Probably involved in ribonucleotide reductase function
ES969_RS09445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES969_RS09450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES969_RS09455	COG4112	unkown
ES969_RS09460	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS09470	COG0464	growth
ES969_RS09475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES969_RS09480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES969_RS09485	COG0789	Transcriptional regulator
ES969_RS09490	COG0174	glutamine synthetase
ES969_RS09495	COG4974	Belongs to the 'phage' integrase family
ES969_RS09515	COG3645	SOS response
ES969_RS09515	COG3646	Phage regulatory protein
ES969_RS09680	COG5412	phage tail tape measure protein
ES969_RS09680	COG3953	SLT domain
ES969_RS09725	COG1388	LysM domain
ES969_RS09725	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS09725	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_RS09735	COG5444	nuclease activity
ES969_RS09790	COG4282	regulation of fungal-type cell wall biogenesis
ES969_RS09810	COG1525	nuclease
ES969_RS09815	COG2814	Major facilitator Superfamily
ES969_RS09820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES969_RS09835	COG0756	dUTP diphosphatase activity
ES969_RS09875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_RS09885	COG3832	glyoxalase III activity
ES969_RS09930	COG4195	phage-related replication protein
ES969_RS09940	COG0346	lactoylglutathione lyase activity
ES969_RS09950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES969_RS09955	COG1388	LysM domain
ES969_RS09960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES969_RS09965	COG4224	UPF0291 protein
ES969_RS09970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES969_RS09980	COG3763	UPF0154 protein
ES969_RS09990	COG0785	Cytochrome C biogenesis protein
ES969_RS09995	COG2201	protein-glutamate methylesterase activity
ES969_RS10000	COG4846	Membrane protein involved in cytochrome C biogenesis
ES969_RS10010	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_RS10025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES969_RS10030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS10050	COG0824	Thioesterase
ES969_RS10060	COG4841	protein insertion into membrane
ES969_RS10065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES969_RS10070	COG1832	CoA-binding protein
ES969_RS10075	COG0187	DNA topoisomerase II activity
ES969_RS10080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES969_RS10090	COG1115	amino acid carrier protein
ES969_RS10095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES969_RS10105	COG5520	Belongs to the glycosyl hydrolase 30 family
ES969_RS10115	COG2246	polysaccharide biosynthetic process
ES969_RS10125	COG0586	Pfam SNARE associated Golgi protein
ES969_RS10130	COG2404	hydrolase activity, acting on ester bonds
ES969_RS10135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES969_RS10140	COG1024	Enoyl-CoA hydratase
ES969_RS10145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES969_RS10150	COG0511	ligase activity, forming carbon-carbon bonds
ES969_RS10155	COG0439	Biotin carboxylase
ES969_RS10160	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS10165	COG1960	acyl-CoA dehydrogenase activity
ES969_RS10175	COG1649	PFAM Uncharacterised BCR, COG1649
ES969_RS10185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES969_RS10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS10195	COG2027	D-alanyl-D-alanine carboxypeptidase
ES969_RS10200	COG2017	converts alpha-aldose to the beta-anomer
ES969_RS10205	COG0534	Mate efflux family protein
ES969_RS10220	COG0582	viral genome integration into host DNA
ES969_RS10225	COG0166	Belongs to the GPI family
ES969_RS10230	COG0405	Gamma-glutamyltransferase
ES969_RS10235	COG0583	DNA-binding transcription factor activity
ES969_RS10240	COG0604	alcohol dehydrogenase
ES969_RS10245	COG0493	'glutamate synthase
ES969_RS10250	COG0069	glutamate synthase activity
ES969_RS10250	COG0070	glutamate synthase
ES969_RS10250	COG0067	glutamate synthase
ES969_RS10255	COG0583	DNA-binding transcription factor activity
ES969_RS10285	COG0300	oxidoreductase activity
ES969_RS10290	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES969_RS10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS10315	COG1131	(ABC) transporter
ES969_RS10325	COG2814	Major facilitator Superfamily
ES969_RS10335	COG2323	membrane
ES969_RS10340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_RS10350	COG2323	membrane
ES969_RS10365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_RS10400	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS10415	COG5278	phosphoserine phosphatase activity
ES969_RS10415	COG0840	transmembrane signaling receptor activity
ES969_RS10420	COG2368	4-hydroxyphenylacetate
ES969_RS10430	COG3619	membrane
ES969_RS10450	COG2140	Oxalate decarboxylase
ES969_RS10480	COG2720	vancomycin resistance protein
ES969_RS10490	COG3655	Transcriptional regulator
ES969_RS10495	COG3739	integral membrane protein
ES969_RS10500	COG0583	DNA-binding transcription factor activity
ES969_RS10505	COG0697	spore germination
ES969_RS10515	COG0693	protein deglycase activity
ES969_RS10520	COG2367	Beta-lactamase
ES969_RS10545	COG0574	Belongs to the PEP-utilizing enzyme family
ES969_RS10545	COG3848	Pyruvate phosphate dikinase
ES969_RS10550	COG0726	polysaccharide deacetylase
ES969_RS10560	COG2314	TM2 domain
ES969_RS10565	COG1396	sequence-specific DNA binding
ES969_RS10640	COG3655	Transcriptional regulator
ES969_RS10685	COG0457	Tetratricopeptide repeat
ES969_RS10690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS10700	COG3328	transposase activity
ES969_RS10725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_RS10730	COG2226	methyltransferase
ES969_RS10735	COG2211	Major facilitator Superfamily
ES969_RS10740	COG3328	transposase activity
ES969_RS10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_RS10805	COG5444	nuclease activity
ES969_RS10810	COG4282	regulation of fungal-type cell wall biogenesis
ES969_RS10815	COG1231	oxidoreductase activity
ES969_RS10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_RS10825	COG0662	Cupin 2, conserved barrel domain protein
ES969_RS10825	COG2207	Transcriptional regulator
ES969_RS10830	COG0456	acetyltransferase
ES969_RS10835	COG1309	transcriptional regulator
ES969_RS10840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS10845	COG3708	Transcriptional regulator
ES969_RS10850	COG2378	regulation of single-species biofilm formation
ES969_RS10860	COG0640	Transcriptional regulator
ES969_RS10865	COG0741	lytic transglycosylase activity
ES969_RS10870	COG2322	membrane
ES969_RS10885	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES969_RS10890	COG3239	Fatty acid desaturase
ES969_RS10895	COG4585	Histidine kinase
ES969_RS10900	COG2197	response regulator
ES969_RS10905	COG1388	LysM domain
ES969_RS10905	COG3584	3D domain protein
ES969_RS10910	COG0514	ATP-dependent DNA helicase (RecQ)
ES969_RS10925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES969_RS10930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_RS10945	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS10975	COG1657	PFAM Prenyltransferase squalene oxidase
ES969_RS10980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES969_RS10985	COG0733	neurotransmitter:sodium symporter activity
ES969_RS10990	COG0385	Bile acid
ES969_RS10995	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_RS11000	COG0567	Dehydrogenase, E1 component
ES969_RS11005	COG4548	von Willebrand factor, type A
ES969_RS11010	COG0714	Associated with various cellular activities
ES969_RS11015	COG2032	superoxide dismutase activity
ES969_RS11020	COG1388	LysM domain
ES969_RS11020	COG0791	NLP P60 protein
ES969_RS11025	COG1819	glycosyl
ES969_RS11030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES969_RS11035	COG0534	Mate efflux family protein
ES969_RS11040	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS11045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_RS11050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_RS11060	COG2962	Rard protein
ES969_RS11080	COG1942	4-Oxalocrotonate Tautomerase
ES969_RS11085	COG1733	regulation of RNA biosynthetic process
ES969_RS11090	COG0778	Nitroreductase
ES969_RS11095	COG0400	carboxylic ester hydrolase activity
ES969_RS11100	COG0346	lactoylglutathione lyase activity
ES969_RS11110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_RS11120	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS11120	COG0793	Belongs to the peptidase S41A family
ES969_RS11125	COG2226	methyltransferase
ES969_RS11135	COG1876	peptidase activity
ES969_RS11140	COG0813	purine-nucleoside phosphorylase activity
ES969_RS11155	COG0671	phosphoesterase, PA-phosphatase related
ES969_RS11180	COG4479	Belongs to the UPF0346 family
ES969_RS11190	COG1509	lysine 2,3-aminomutase activity
ES969_RS11195	COG0456	acetyltransferase
ES969_RS11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_RS11205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES969_RS11210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES969_RS11215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_RS11230	COG0456	acetyltransferase
ES969_RS11235	COG0463	Glycosyl transferase, family 2
ES969_RS11250	COG4641	Protein conserved in bacteria
ES969_RS11255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES969_RS11260	COG1086	Polysaccharide biosynthesis protein
ES969_RS11265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES969_RS11270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES969_RS11275	COG1846	Transcriptional regulator
ES969_RS11280	COG0534	Mate efflux family protein
ES969_RS11290	COG4698	Protein conserved in bacteria
ES969_RS11295	COG2755	lipolytic protein G-D-S-L family
ES969_RS11300	COG1999	signal sequence binding
ES969_RS11310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES969_RS11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES969_RS11320	COG1272	protein, Hemolysin III
ES969_RS11325	COG0204	Acyl-transferase
ES969_RS11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES969_RS11335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES969_RS11345	COG2521	methyltransferase
ES969_RS11345	COG2136	Putative SAM-dependent methyltransferase
ES969_RS11355	COG0129	dihydroxy-acid dehydratase activity
ES969_RS11360	COG1413	lyase activity
ES969_RS11365	COG1418	mRNA catabolic process
ES969_RS11370	COG0386	Belongs to the glutathione peroxidase family
ES969_RS11375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES969_RS11380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES969_RS11390	COG1278	Cold shock
ES969_RS11410	COG0328	RNA-DNA hybrid ribonuclease activity
ES969_RS11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES969_RS11420	COG0328	RNA-DNA hybrid ribonuclease activity
ES969_RS11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_RS11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES969_RS11455	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES969_RS11465	COG2233	PERMEase
ES969_RS11470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_RS11475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES969_RS11485	COG0800	Aldolase
ES969_RS11490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_RS11495	COG1609	Transcriptional regulator
ES969_RS11500	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES969_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS11510	COG1199	ATP-dependent helicase activity
ES969_RS11525	COG0116	Belongs to the methyltransferase superfamily
ES969_RS11540	COG4474	Belongs to the UPF0398 family
ES969_RS11555	COG3359	exonuclease
ES969_RS11560	COG1205	dead DEAH box helicase
ES969_RS11560	COG1111	helicase
ES969_RS11565	COG2190	(PTS) system
ES969_RS11570	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_RS11605	COG3331	DNA recombination
ES969_RS11610	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES969_RS11610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_RS11620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES969_RS11625	COG3935	DnaD domain protein
ES969_RS11630	COG0017	Asparaginyl-tRNA synthetase
ES969_RS11635	COG0436	Aminotransferase
ES969_RS11640	COG5353	protein conserved in bacteria
ES969_RS11650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES969_RS11650	COG1199	ATP-dependent helicase activity
ES969_RS11655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES969_RS11660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES969_RS11665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES969_RS11670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES969_RS11670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES969_RS11675	COG0617	tRNA 3'-terminal CCA addition
ES969_RS11680	COG0438	transferase activity, transferring glycosyl groups
ES969_RS11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_RS11690	COG1803	Methylglyoxal synthase
ES969_RS11695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES969_RS11700	COG1694	Mazg nucleotide pyrophosphohydrolase
ES969_RS11705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS11715	COG4347	Protein of unknown function (DUF1405)
ES969_RS11720	COG2010	Cytochrome c
ES969_RS11720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES969_RS11725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES969_RS11730	COG0723	plastoquinol--plastocyanin reductase activity
ES969_RS11740	COG5582	Belongs to the UPF0302 family
ES969_RS11745	COG0457	Tetratricopeptide repeat
ES969_RS11750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES969_RS11755	COG0287	Prephenate dehydrogenase
ES969_RS11770	COG0133	tryptophan synthase activity
ES969_RS11775	COG0135	phosphoribosylanthranilate isomerase activity
ES969_RS11785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES969_RS11790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES969_RS11795	COG4401	Chorismate mutase type I
ES969_RS11800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES969_RS11805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES969_RS11810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES969_RS11815	COG0105	UTP biosynthetic process
ES969_RS11820	COG0142	geranyltranstransferase activity
ES969_RS11825	COG2226	methyltransferase
ES969_RS11830	COG0142	geranyltranstransferase activity
ES969_RS11840	COG0302	gtp cyclohydrolase
ES969_RS11845	COG0776	regulation of translation
ES969_RS11850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES969_RS11865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES969_RS11870	COG1160	GTP binding
ES969_RS11900	COG1304	FMN binding
ES969_RS11905	COG0539	negative regulation of cytoplasmic translation
ES969_RS11910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES969_RS11920	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES969_RS11925	COG2959	enzyme of heme biosynthesis
ES969_RS11930	COG3773	Cell wall hydrolase
ES969_RS11930	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS11935	COG2339	peptidase activity
ES969_RS11940	COG0492	ferredoxin-NADP+ reductase activity
ES969_RS11945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_RS11950	COG4862	establishment of competence for transformation
ES969_RS11955	COG1408	metallophosphoesterase
ES969_RS11965	COG1388	LysM domain
ES969_RS11970	COG1266	CAAX protease self-immunity
ES969_RS11975	COG0514	ATP-dependent DNA helicase (RecQ)
ES969_RS11980	COG4955	Helix-turn-helix domain
ES969_RS11985	COG1141	Ferredoxin
ES969_RS11990	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES969_RS11995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES969_RS12000	COG0710	3-dehydroquinate dehydratase activity
ES969_RS12010	COG1595	DNA-templated transcription, initiation
ES969_RS12015	COG5002	protein histidine kinase activity
ES969_RS12020	COG0745	RESPONSE REGULATOR receiver
ES969_RS12025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES969_RS12030	COG1333	cytochrome c biogenesis protein
ES969_RS12035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS12040	COG1187	pseudouridine synthase activity
ES969_RS12045	COG0700	Nucleoside recognition
ES969_RS12050	COG2715	membrane protein required for spore maturation
ES969_RS12055	COG1686	Belongs to the peptidase S11 family
ES969_RS12065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES969_RS12070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES969_RS12075	COG1547	Domain of unknown function (DUF309)
ES969_RS12080	COG0456	acetyltransferase
ES969_RS12085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES969_RS12090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES969_RS12090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES969_RS12095	COG0307	riboflavin synthase, alpha
ES969_RS12100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES969_RS12100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES969_RS12110	COG0681	Belongs to the peptidase S26 family
ES969_RS12115	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES969_RS12165	COG3328	transposase activity
ES969_RS12175	COG3012	SEC-C Motif Domain Protein
ES969_RS12185	COG0457	Tetratricopeptide repeat
ES969_RS12195	COG3328	transposase activity
ES969_RS12250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES969_RS12265	COG4086	secreted protein
ES969_RS12270	COG0019	diaminopimelate decarboxylase activity
ES969_RS12275	COG0697	spore germination
ES969_RS12290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_RS12310	COG1191	sigma factor activity
ES969_RS12315	COG2172	sigma factor antagonist activity
ES969_RS12320	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS12325	COG1686	Belongs to the peptidase S11 family
ES969_RS12330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES969_RS12335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES969_RS12340	COG4974	Belongs to the 'phage' integrase family
ES969_RS12350	COG0735	belongs to the Fur family
ES969_RS12355	COG1300	Membrane
ES969_RS12365	COG0281	malic enzyme
ES969_RS12370	COG1757	Na H antiporter
ES969_RS12375	COG1027	Aspartate ammonia-lyase
ES969_RS12380	COG0252	asparaginase activity
ES969_RS12385	COG1396	sequence-specific DNA binding
ES969_RS12390	COG1379	DNA repair
ES969_RS12395	COG0494	nUDIX hydrolase
ES969_RS12405	COG0667	Aldo Keto reductase
ES969_RS12415	COG1073	alpha beta
ES969_RS12425	COG4918	Iron-sulphur cluster biosynthesis
ES969_RS12430	COG0456	acetyltransferase
ES969_RS12430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES969_RS12435	COG2329	Antibiotic biosynthesis monooxygenase
ES969_RS12440	COG0456	acetyltransferase
ES969_RS12450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES969_RS12460	COG2211	Major facilitator Superfamily
ES969_RS12465	COG0346	lactoylglutathione lyase activity
ES969_RS12470	COG1072	(Pantothenic acid kinase))
ES969_RS12475	COG3048	D-serine ammonia-lyase activity
ES969_RS12480	COG0300	oxidoreductase activity
ES969_RS12485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS12490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_RS12495	COG4187	Peptidase family M20/M25/M40
ES969_RS12500	COG1902	pentaerythritol trinitrate reductase activity
ES969_RS12505	COG0596	Alpha beta hydrolase
ES969_RS12515	COG1234	tRNA 3'-trailer cleavage
ES969_RS12520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES969_RS12525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES969_RS12530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES969_RS12540	COG0706	membrane insertase activity
ES969_RS12545	COG3361	conserved protein (COG2071)
ES969_RS12550	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES969_RS12555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES969_RS12560	COG0346	lactoylglutathione lyase activity
ES969_RS12565	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_RS12570	COG4129	membrane
ES969_RS12575	COG1126	abc transporter atp-binding protein
ES969_RS12580	COG0765	amino acid transport
ES969_RS12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_RS12595	COG1597	lipid kinase activity
ES969_RS12605	COG0789	Transcriptional regulator
ES969_RS12605	COG4978	Transcriptional regulator
ES969_RS12610	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_RS12615	COG0022	dehydrogenase e1 component
ES969_RS12620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_RS12625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_RS12630	COG3426	butyrate kinase activity
ES969_RS12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_RS12640	COG0280	phosphate acetyltransferase
ES969_RS12645	COG3290	protein histidine kinase activity
ES969_RS12645	COG3829	transcription factor binding
ES969_RS12655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES969_RS12660	COG2079	MmgE PrpD family protein
ES969_RS12665	COG0372	Belongs to the citrate synthase family
ES969_RS12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES969_RS12680	COG0183	Belongs to the thiolase family
ES969_RS12685	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_RS12690	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS12705	COG1902	pentaerythritol trinitrate reductase activity
ES969_RS12710	COG0745	RESPONSE REGULATOR receiver
ES969_RS12720	COG0750	zinc metalloprotease
ES969_RS12725	COG0497	DNA recombination
ES969_RS12730	COG1438	arginine binding
ES969_RS12735	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES969_RS12740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES969_RS12745	COG0142	geranyltranstransferase activity
ES969_RS12750	COG1722	exodeoxyribonuclease VII activity
ES969_RS12755	COG1570	exodeoxyribonuclease VII activity
ES969_RS12760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES969_RS12765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES969_RS12770	COG1302	Protein conserved in bacteria
ES969_RS12775	COG0439	Biotin carboxylase
ES969_RS12780	COG0511	ligase activity, forming carbon-carbon bonds
ES969_RS12820	COG3854	ATPases associated with a variety of cellular activities
ES969_RS12830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES969_RS12835	COG0006	proline dipeptidase activity
ES969_RS12840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES969_RS12850	COG3872	metal-dependent enzyme
ES969_RS12860	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES969_RS12865	COG1321	iron dependent repressor
ES969_RS12870	COG0095	Lipoate-protein ligase
ES969_RS12875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES969_RS12880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES969_RS12885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES969_RS12890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES969_RS12895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES969_RS12910	COG1396	sequence-specific DNA binding
ES969_RS12920	COG0681	Belongs to the peptidase S26 family
ES969_RS12945	COG4940	Competence protein ComGF
ES969_RS12955	COG4970	Tfp pilus assembly protein FimT
ES969_RS12960	COG4537	Required for transformation and DNA binding
ES969_RS12965	COG1459	type II secretion system
ES969_RS12970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES969_RS12975	COG0517	IMP dehydrogenase activity
ES969_RS12980	COG0598	Magnesium transport protein CorA
ES969_RS12985	COG1253	flavin adenine dinucleotide binding
ES969_RS12990	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS13000	COG1393	Belongs to the ArsC family
ES969_RS13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS13020	COG0011	TIGRFAM Protein of
ES969_RS13030	COG2866	Carboxypeptidase
ES969_RS13035	COG1368	sulfuric ester hydrolase activity
ES969_RS13040	COG1940	carbohydrate kinase activity
ES969_RS13045	COG4483	Protein conserved in bacteria
ES969_RS13050	COG0705	Rhomboid family
ES969_RS13050	COG0457	Tetratricopeptide repeat
ES969_RS13060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES969_RS13070	COG0438	transferase activity, transferring glycosyl groups
ES969_RS13085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES969_RS13090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_RS13095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_RS13100	COG0581	inorganic phosphate transmembrane transporter activity
ES969_RS13105	COG0573	inorganic phosphate transmembrane transporter activity
ES969_RS13110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES969_RS13115	COG0768	penicillin binding
ES969_RS13120	COG0477	Major facilitator Superfamily
ES969_RS13125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES969_RS13130	COG2839	Protein conserved in bacteria
ES969_RS13135	COG5521	maltodextrose utilization protein MalA
ES969_RS13140	COG1388	LysM domain
ES969_RS13145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES969_RS13150	COG4709	membrane
ES969_RS13155	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES969_RS13160	COG0735	belongs to the Fur family
ES969_RS13165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS13175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES969_RS13180	COG0513	Belongs to the DEAD box helicase family
ES969_RS13190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES969_RS13195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES969_RS13200	COG2384	SAM-dependent methyltransferase
ES969_RS13205	COG2010	Cytochrome c
ES969_RS13215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES969_RS13220	COG0358	DNA primase activity
ES969_RS13225	COG1671	Belongs to the UPF0178 family
ES969_RS13230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES969_RS13235	COG0517	IMP dehydrogenase activity
ES969_RS13240	COG0751	glycine-tRNA ligase activity
ES969_RS13245	COG0752	glycyl-tRNA synthetase alpha subunit
ES969_RS13250	COG1381	Involved in DNA repair and RecF pathway recombination
ES969_RS13260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES969_RS13265	COG0295	cytidine deaminase activity
ES969_RS13270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES969_RS13275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES969_RS13280	COG1480	7TM receptor with intracellular HD hydrolase
ES969_RS13285	COG1702	phosphate starvation-inducible protein PhoH
ES969_RS13290	COG0561	phosphatase activity
ES969_RS13305	COG4864	UPF0365 protein
ES969_RS13310	COG1030	water channel activity
ES969_RS13315	COG1610	YqeY-like protein
ES969_RS13325	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES969_RS13330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES969_RS13335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES969_RS13340	COG2264	protein methyltransferase activity
ES969_RS13345	COG0484	heat shock protein binding
ES969_RS13350	COG0443	Heat shock 70 kDa protein
ES969_RS13355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES969_RS13360	COG1420	regulation of RNA biosynthetic process
ES969_RS13365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES969_RS13370	COG0481	GTPase activity
ES969_RS13380	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS13385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES969_RS13390	COG0268	Binds directly to 16S ribosomal RNA
ES969_RS13395	COG1466	dna polymerase III delta subunit
ES969_RS13410	COG2333	competence protein COMEC
ES969_RS13410	COG0658	competence protein
ES969_RS13415	COG2131	deaminase
ES969_RS13420	COG1596	polysaccharide export
ES969_RS13420	COG1555	photosystem II stabilization
ES969_RS13425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_RS13430	COG2226	methyltransferase
ES969_RS13435	COG0799	negative regulation of ribosome biogenesis
ES969_RS13440	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES969_RS13445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES969_RS13450	COG1534	Rna-binding protein
ES969_RS13455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES969_RS13460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES969_RS13465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES969_RS13475	COG2755	lipolytic protein G-D-S-L family
ES969_RS13480	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_RS13480	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS13490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES969_RS13500	COG3209	COG3209 Rhs family protein
ES969_RS13520	COG0114	fumarate hydratase activity
ES969_RS13525	COG0583	DNA-binding transcription factor activity
ES969_RS13540	COG0457	Tetratricopeptide repeat
ES969_RS13665	COG0789	Transcriptional regulator
ES969_RS13665	COG4978	Transcriptional regulator
ES969_RS13670	COG2814	Major facilitator Superfamily
ES969_RS13675	COG0456	acetyltransferase
ES969_RS13680	COG3328	transposase activity
ES969_RS13690	COG1253	flavin adenine dinucleotide binding
ES969_RS13700	COG0697	spore germination
ES969_RS13705	COG0583	DNA-binding transcription factor activity
ES969_RS13710	COG2072	flavoprotein involved in K transport
ES969_RS13715	COG1230	cation diffusion facilitator family transporter
ES969_RS13725	COG1114	Component of the transport system for branched-chain amino acids
ES969_RS13730	COG1687	branched-chain amino acid
ES969_RS13735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES969_RS13740	COG1522	sequence-specific DNA binding
ES969_RS13745	COG2732	(Barnase) inhibitor
ES969_RS13750	COG2124	cytochrome p450
ES969_RS13760	COG1335	isochorismatase
ES969_RS13775	COG2318	DinB family
ES969_RS13785	COG2070	2-Nitropropane dioxygenase
ES969_RS13800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES969_RS13820	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES969_RS13830	COG0667	Aldo Keto reductase
ES969_RS13835	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS13840	COG5566	PFAM Mor transcription activator
ES969_RS13845	COG0596	Alpha beta hydrolase
ES969_RS13850	COG4991	sh3 domain protein
ES969_RS13855	COG4991	sh3 domain protein
ES969_RS13865	COG0346	lactoylglutathione lyase activity
ES969_RS13875	COG5577	PFAM Coat F domain
ES969_RS13880	COG1063	alcohol dehydrogenase
ES969_RS13890	COG5577	PFAM Coat F domain
ES969_RS13895	COG0789	Transcriptional regulator
ES969_RS13905	COG1064	alcohol dehydrogenase
ES969_RS13910	COG0693	protein deglycase activity
ES969_RS13915	COG1621	beta-fructofuranosidase activity
ES969_RS13920	COG3716	PTS system mannose fructose sorbose family IID component
ES969_RS13925	COG3715	PTS system
ES969_RS13930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS13935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS13940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES969_RS13940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES969_RS13950	COG1113	amino acid transport
ES969_RS13955	COG1280	lysine exporter protein (LysE YggA)
ES969_RS13960	COG1378	Sugar-specific transcriptional regulator TrmB
ES969_RS13965	COG1595	DNA-templated transcription, initiation
ES969_RS13975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES969_RS13975	COG2755	lipolytic protein G-D-S-L family
ES969_RS13985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_RS13985	COG2124	cytochrome p450
ES969_RS13990	COG1309	transcriptional regulator
ES969_RS13995	COG2226	methyltransferase
ES969_RS14010	COG2116	formate transmembrane transporter activity
ES969_RS14015	COG5609	conserved protein (DUF2294)
ES969_RS14020	COG3383	formate dehydrogenase (NAD+) activity
ES969_RS14025	COG2427	Protein of unknown function (DUF1641)
ES969_RS14035	COG0626	cystathionine gamma-synthase activity
ES969_RS14040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_RS14045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES969_RS14050	COG2226	methyltransferase
ES969_RS14065	COG0768	penicillin binding
ES969_RS14070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES969_RS14075	COG0572	uridine kinase
ES969_RS14080	COG0826	peptidase U32
ES969_RS14085	COG0826	peptidase U32
ES969_RS14090	COG4122	O-methyltransferase activity
ES969_RS14095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES969_RS14100	COG3906	Belongs to the UPF0473 family
ES969_RS14105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES969_RS14110	COG4472	Bacterial protein of unknown function (DUF965)
ES969_RS14115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES969_RS14120	COG0628	permease
ES969_RS14125	COG1126	abc transporter atp-binding protein
ES969_RS14130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_RS14135	COG0765	amino acid transport
ES969_RS14140	COG0765	amino acid transport
ES969_RS14155	COG3881	PFAM PRC-barrel domain
ES969_RS14160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES969_RS14165	COG0457	Tetratricopeptide repeat
ES969_RS14170	COG0482	sulfurtransferase activity
ES969_RS14175	COG1104	cysteine desulfurase activity
ES969_RS14180	COG1959	2 iron, 2 sulfur cluster binding
ES969_RS14185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES969_RS14190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES969_RS14200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES969_RS14205	COG0124	histidyl-tRNA synthetase
ES969_RS14215	COG4991	sh3 domain protein
ES969_RS14215	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS14215	COG3103	Sh3 type 3 domain protein
ES969_RS14220	COG1490	D-aminoacyl-tRNA deacylase activity
ES969_RS14225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES969_RS14230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_RS14235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES969_RS14235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES969_RS14240	COG5416	Lipopolysaccharide assembly protein A domain
ES969_RS14245	COG0490	domain, Protein
ES969_RS14250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES969_RS14250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES969_RS14260	COG2244	polysaccharide biosynthetic process
ES969_RS14265	COG2323	membrane
ES969_RS14275	COG1862	Preprotein translocase
ES969_RS14280	COG0343	queuine tRNA-ribosyltransferase activity
ES969_RS14285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES969_RS14295	COG2255	four-way junction helicase activity
ES969_RS14300	COG0632	four-way junction helicase activity
ES969_RS14310	COG2814	Major facilitator Superfamily
ES969_RS14315	COG0673	inositol 2-dehydrogenase activity
ES969_RS14320	COG2112	serine threonine protein kinase
ES969_RS14340	COG1115	amino acid carrier protein
ES969_RS14345	COG0217	transcriptional regulatory protein
ES969_RS14355	COG1388	LysM domain
ES969_RS14360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES969_RS14365	COG0157	Belongs to the NadC ModD family
ES969_RS14370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES969_RS14375	COG1104	cysteine desulfurase activity
ES969_RS14380	COG1827	regulation of RNA biosynthetic process
ES969_RS14385	COG0077	Prephenate dehydratase
ES969_RS14390	COG4492	Belongs to the UPF0735 family
ES969_RS14395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES969_RS14400	COG3290	protein histidine kinase activity
ES969_RS14410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES969_RS14415	COG2868	ribosomal protein
ES969_RS14420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES969_RS14425	COG1994	Peptidase M50
ES969_RS14430	COG0739	heme binding
ES969_RS14435	COG2894	cell division
ES969_RS14440	COG0850	regulation of cytokinetic process
ES969_RS14445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES969_RS14455	COG1077	Cell shape determining protein MreB Mrl
ES969_RS14460	COG2003	Belongs to the UPF0758 family
ES969_RS14465	COG0424	maF-like protein
ES969_RS14475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES969_RS14480	COG0285	dihydrofolate synthase activity
ES969_RS14485	COG0525	valine-tRNA ligase activity
ES969_RS14495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_RS14500	COG1388	LysM domain
ES969_RS14505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES969_RS14510	COG0113	porphobilinogen synthase activity
ES969_RS14515	COG1587	Uroporphyrinogen-III synthase
ES969_RS14520	COG0181	hydroxymethylbilane synthase activity
ES969_RS14525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES969_RS14530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES969_RS14540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES969_RS14545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES969_RS14550	COG0470	DNA polymerase III
ES969_RS14550	COG1067	ATP-dependent peptidase activity
ES969_RS14555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES969_RS14560	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES969_RS14565	COG1477	protein flavinylation
ES969_RS14565	COG0457	Tetratricopeptide repeat
ES969_RS14570	COG0066	3-isopropylmalate dehydratase activity
ES969_RS14575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES969_RS14580	COG0473	3-isopropylmalate dehydrogenase activity
ES969_RS14585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES969_RS14590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES969_RS14595	COG0440	acetolactate synthase activity
ES969_RS14600	COG0028	Belongs to the TPP enzyme family
ES969_RS14615	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES969_RS14625	COG0622	Phosphoesterase
ES969_RS14630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES969_RS14635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES969_RS14640	COG5401	PFAM Sporulation and spore germination
ES969_RS14645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES969_RS14650	COG1846	Transcriptional regulator
ES969_RS14655	COG2197	response regulator
ES969_RS14660	COG0824	Thioesterase
ES969_RS14665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES969_RS14670	COG1053	succinate dehydrogenase
ES969_RS14675	COG2009	succinate dehydrogenase
ES969_RS14680	COG1719	4-vinyl reductase, 4VR
ES969_RS14685	COG0527	aspartate kinase activity
ES969_RS14695	COG0322	excinuclease ABC activity
ES969_RS14700	COG3118	belongs to the thioredoxin family
ES969_RS14705	COG3534	alpha-L-arabinofuranosidase
ES969_RS14710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES969_RS14715	COG2086	electron transfer activity
ES969_RS14720	COG1024	Enoyl-CoA hydratase
ES969_RS14725	COG1309	transcriptional regulator
ES969_RS14730	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS14735	COG3766	membrane
ES969_RS14740	COG1193	negative regulation of DNA recombination
ES969_RS14745	COG1796	DNA polymerase
ES969_RS14745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES969_RS14750	COG1286	toxin biosynthetic process
ES969_RS14755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES969_RS14760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES969_RS14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_RS14765	COG0072	phenylalanine-tRNA ligase activity
ES969_RS14770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES969_RS14780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES969_RS14790	COG3835	regulator
ES969_RS14795	COG0277	FAD linked oxidase domain protein
ES969_RS14800	COG0247	lactate metabolic process
ES969_RS14805	COG0346	lactoylglutathione lyase activity
ES969_RS14815	COG3534	alpha-L-arabinofuranosidase
ES969_RS14820	COG0395	ABC-type sugar transport system, permease component
ES969_RS14825	COG1175	transmembrane transport
ES969_RS14830	COG1653	transport
ES969_RS14835	COG0371	Dehydrogenase
ES969_RS14840	COG0647	UMP catabolic process
ES969_RS14845	COG0235	Class ii aldolase
ES969_RS14850	COG1069	ribulokinase activity
ES969_RS14855	COG2160	L-arabinose isomerase activity
ES969_RS14860	COG3507	Belongs to the glycosyl hydrolase 43 family
ES969_RS14865	COG1363	Peptidase, m42
ES969_RS14875	COG3326	Membrane
ES969_RS14880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES969_RS14885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES969_RS14890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES969_RS14900	COG1346	cytolysis
ES969_RS14905	COG1380	Effector of murein hydrolase LrgA
ES969_RS14910	COG3279	Response regulator of the LytR AlgR family
ES969_RS14915	COG3275	phosphorelay sensor kinase activity
ES969_RS14920	COG1011	Hydrolase
ES969_RS14925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES969_RS14935	COG0398	Pfam SNARE associated Golgi protein
ES969_RS14940	COG1484	DNA-dependent DNA replication
ES969_RS14945	COG3611	Membrane attachment protein
ES969_RS14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES969_RS14955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES969_RS14960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES969_RS14965	COG1733	regulation of RNA biosynthetic process
ES969_RS14970	COG2814	Major facilitator Superfamily
ES969_RS14975	COG0656	L-ascorbic acid biosynthetic process
ES969_RS14980	COG0237	dephospho-CoA kinase activity
ES969_RS14985	COG1971	Probably functions as a manganese efflux pump
ES969_RS14990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES969_RS14995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_RS14995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_RS15000	COG5002	protein histidine kinase activity
ES969_RS15005	COG0745	RESPONSE REGULATOR receiver
ES969_RS15010	COG0039	L-malate dehydrogenase activity
ES969_RS15015	COG0538	isocitrate dehydrogenase activity
ES969_RS15020	COG0372	Belongs to the citrate synthase family
ES969_RS15025	COG2707	UPF0756 membrane protein
ES969_RS15030	COG0628	permease
ES969_RS15035	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES969_RS15040	COG0469	pyruvate kinase activity
ES969_RS15045	COG0205	6-phosphofructokinase activity
ES969_RS15050	COG0825	malonyl-CoA metabolic process
ES969_RS15055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES969_RS15060	COG0281	malic enzyme
ES969_RS15065	COG0587	DNA-directed DNA polymerase activity
ES969_RS15085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES969_RS15095	COG4109	DRTGG domain
ES969_RS15100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES969_RS15105	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS15115	COG0165	Argininosuccinate lyase
ES969_RS15120	COG0137	argininosuccinate synthase activity
ES969_RS15125	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES969_RS15130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES969_RS15140	COG0827	DNA restriction-modification system
ES969_RS15145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES969_RS15150	COG3874	Sporulation protein YtfJ
ES969_RS15160	COG1714	RDD family
ES969_RS15165	COG0616	signal peptide processing
ES969_RS15170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES969_RS15175	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES969_RS15180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES969_RS15190	COG0301	tRNA thio-modification
ES969_RS15195	COG1104	cysteine desulfurase activity
ES969_RS15200	COG1114	Component of the transport system for branched-chain amino acids
ES969_RS15205	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES969_RS15210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES969_RS15215	COG1309	transcriptional regulator
ES969_RS15220	COG1956	GAF domain-containing protein
ES969_RS15225	COG2203	Gaf domain
ES969_RS15225	COG2199	diguanylate cyclase activity
ES969_RS15235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES969_RS15240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES969_RS15250	COG0454	-acetyltransferase
ES969_RS15255	COG0517	IMP dehydrogenase activity
ES969_RS15260	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES969_RS15265	COG1360	Flagellar Motor Protein
ES969_RS15270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES969_RS15275	COG1609	Transcriptional regulator
ES969_RS15280	COG1605	Chorismate mutase
ES969_RS15280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES969_RS15285	COG3118	belongs to the thioredoxin family
ES969_RS15290	COG4980	gas vesicle protein
ES969_RS15295	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES969_RS15300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES969_RS15305	COG1674	ftsk spoiiie
ES969_RS15310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_RS15315	COG4848	Belongs to the UPF0354 family
ES969_RS15320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS15335	COG1363	Peptidase, m42
ES969_RS15340	COG5584	Small secreted protein
ES969_RS15345	COG0281	malic enzyme
ES969_RS15350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_RS15355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES969_RS15365	COG0510	thiamine kinase activity
ES969_RS15370	COG1523	belongs to the glycosyl hydrolase 13 family
ES969_RS15375	COG1597	lipid kinase activity
ES969_RS15385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES969_RS15390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_RS15395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_RS15400	COG2252	PERMEase
ES969_RS15405	COG4473	ABC transporter
ES969_RS15410	COG1131	(ABC) transporter
ES969_RS15415	COG1349	DNA-binding transcription factor activity
ES969_RS15420	COG1187	pseudouridine synthase activity
ES969_RS15425	COG2244	polysaccharide biosynthetic process
ES969_RS15430	COG2081	HI0933 family
ES969_RS15435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES969_RS15455	COG1653	transport
ES969_RS15460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES969_RS15465	COG4209	transmembrane transport
ES969_RS15475	COG1653	transport
ES969_RS15480	COG0395	ABC-type sugar transport system, permease component
ES969_RS15485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_RS15490	COG2124	cytochrome p450
ES969_RS15510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_RS15520	COG1073	alpha beta
ES969_RS15525	COG1609	Transcriptional regulator
ES969_RS15530	COG1653	transport
ES969_RS15535	COG1175	transmembrane transport
ES969_RS15540	COG0395	ABC-type sugar transport system, permease component
ES969_RS15545	COG1486	melibiose metabolic process
ES969_RS15550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES969_RS15555	COG0495	leucyl-tRNA aminoacylation
ES969_RS15565	COG2202	Pas domain
ES969_RS15565	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_RS15570	COG2814	Major facilitator Superfamily
ES969_RS15575	COG2433	Pfam Transposase IS66
ES969_RS15585	COG0577	efflux transmembrane transporter activity
ES969_RS15590	COG1136	(ABC) transporter
ES969_RS15595	COG2205	protein histidine kinase activity
ES969_RS15600	COG0745	RESPONSE REGULATOR receiver
ES969_RS15605	COG0577	efflux transmembrane transporter activity
ES969_RS15610	COG1136	(ABC) transporter
ES969_RS15625	COG1131	(ABC) transporter
ES969_RS15630	COG1725	Transcriptional regulator
ES969_RS15645	COG1242	4 iron, 4 sulfur cluster binding
ES969_RS15650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES969_RS15660	COG2267	carboxylic ester hydrolase activity
ES969_RS15665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES969_RS15670	COG1113	amino acid transport
ES969_RS15675	COG0367	asparagine synthase
ES969_RS15680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES969_RS15685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES969_RS15695	COG1506	peptidase
ES969_RS15700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES969_RS15705	COG1116	anion transmembrane transporter activity
ES969_RS15710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES969_RS15715	COG0494	nUDIX hydrolase
ES969_RS15720	COG4824	toxin secretion phage lysis holin
ES969_RS15725	COG0783	Belongs to the Dps family
ES969_RS15740	COG1854	S-ribosylhomocysteine lyase activity
ES969_RS15745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES969_RS15750	COG0288	reversible hydration of carbon dioxide
ES969_RS15755	COG0254	rRNA binding
ES969_RS15760	COG1271	oxidase subunit
ES969_RS15765	COG1294	oxidase, subunit
ES969_RS15775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_RS15780	COG1321	iron dependent repressor
ES969_RS15780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_RS15785	COG1121	(ABC) transporter
ES969_RS15790	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES969_RS15795	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_RS15800	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_RS15805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES969_RS15810	COG0596	Alpha beta hydrolase
ES969_RS15815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES969_RS15820	COG1169	isochorismate synthase
ES969_RS15830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_RS15835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES969_RS15840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_RS15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_RS15850	COG0438	transferase activity, transferring glycosyl groups
ES969_RS15860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_RS15865	COG0438	transferase activity, transferring glycosyl groups
ES969_RS15870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_RS15875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES969_RS15880	COG0058	SHG alpha-glucan phosphorylase activity
ES969_RS15885	COG0297	glycogen (starch) synthase activity
ES969_RS15890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES969_RS15895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES969_RS15900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES969_RS16025	COG3859	Proton-coupled thiamine transporter YuaJ
ES969_RS16030	COG1247	-acetyltransferase
ES969_RS16035	COG2268	Band 7 protein
ES969_RS16040	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES969_RS16045	COG2318	DinB family
ES969_RS16055	COG1454	alcohol dehydrogenase
ES969_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS16065	COG1510	regulation of RNA biosynthetic process
ES969_RS16075	COG0569	domain protein
ES969_RS16080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES969_RS16085	COG4682	membrane
ES969_RS16090	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES969_RS16095	COG0477	Major facilitator Superfamily
ES969_RS16100	COG5553	Cysteine dioxygenase type I
ES969_RS16110	COG1968	undecaprenyl-diphosphatase activity
ES969_RS16115	COG0628	permease
ES969_RS16120	COG0673	inositol 2-dehydrogenase activity
ES969_RS16125	COG4806	L-rhamnose isomerase
ES969_RS16130	COG3254	rhamnose metabolic process
ES969_RS16135	COG1070	Carbohydrate kinase
ES969_RS16140	COG1349	DNA-binding transcription factor activity
ES969_RS16145	COG3347	Dehydrogenase
ES969_RS16145	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS16160	COG0840	transmembrane signaling receptor activity
ES969_RS16165	COG0840	transmembrane signaling receptor activity
ES969_RS16170	COG0840	transmembrane signaling receptor activity
ES969_RS16185	COG0432	Pfam Uncharacterised protein family UPF0047
ES969_RS16195	COG0366	Alpha amylase catalytic
ES969_RS16200	COG1253	flavin adenine dinucleotide binding
ES969_RS16205	COG2738	Putative neutral zinc metallopeptidase
ES969_RS16220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES969_RS16235	COG0166	Belongs to the GPI family
ES969_RS16240	COG1979	alcohol dehydrogenase
ES969_RS16245	COG1979	alcohol dehydrogenase
ES969_RS16250	COG2155	Conserved Protein
ES969_RS16255	COG1098	S1 RNA binding domain
ES969_RS16260	COG0436	Aminotransferase
ES969_RS16265	COG1522	sequence-specific DNA binding
ES969_RS16270	COG2267	carboxylic ester hydrolase activity
ES969_RS16280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES969_RS16285	COG2205	protein histidine kinase activity
ES969_RS16295	COG5018	Exonuclease
ES969_RS16305	COG2814	Major facilitator Superfamily
ES969_RS16310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_RS16315	COG3011	Protein conserved in bacteria
ES969_RS16325	COG3290	protein histidine kinase activity
ES969_RS16330	COG4565	transcriptional regulatory protein
ES969_RS16335	COG1744	ABC transporter substrate-binding protein PnrA-like
ES969_RS16340	COG3845	ABC transporter
ES969_RS16345	COG4603	Belongs to the binding-protein-dependent transport system permease family
ES969_RS16350	COG1079	Belongs to the binding-protein-dependent transport system permease family
ES969_RS16355	COG3493	citrate carrier protein
ES969_RS16365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES969_RS16365	COG2111	Na H antiporter
ES969_RS16370	COG2111	Na H antiporter
ES969_RS16375	COG1006	Multisubunit Na H antiporter MnhC subunit
ES969_RS16380	COG0651	ATP synthesis coupled electron transport
ES969_RS16385	COG1863	multisubunit Na H antiporter MnhE subunit
ES969_RS16390	COG2212	antiporter activity
ES969_RS16395	COG1320	monovalent cation:proton antiporter activity
ES969_RS16400	COG2050	protein possibly involved in aromatic compounds catabolism
ES969_RS16405	COG2197	response regulator
ES969_RS16410	COG4585	Histidine kinase
ES969_RS16420	COG0142	geranyltranstransferase activity
ES969_RS16440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES969_RS16445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES969_RS16450	COG1335	isochorismatase
ES969_RS16455	COG5506	Protein of unknown function (DUF1694)
ES969_RS16470	COG0628	permease
ES969_RS16485	COG1418	mRNA catabolic process
ES969_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS16500	COG1511	domain protein
ES969_RS16505	COG1674	ftsk spoiiie
ES969_RS16505	COG0433	COG0433 Predicted ATPase
ES969_RS16510	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES969_RS16515	COG5417	Belongs to the EsaB family
ES969_RS16520	COG4842	Belongs to the WXG100 family
ES969_RS16530	COG2508	Transcriptional regulator
ES969_RS16530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES969_RS16535	COG0686	Belongs to the AlaDH PNT family
ES969_RS16540	COG5634	Uncharacterized conserved protein (DUF2278)
ES969_RS16545	COG3251	PFAM MbtH domain protein
ES969_RS16550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS16555	COG1535	isochorismatase
ES969_RS16555	COG3433	isochorismatase activity
ES969_RS16560	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES969_RS16565	COG1169	isochorismate synthase
ES969_RS16570	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS16575	COG2819	hydrolase of the alpha beta superfamily
ES969_RS16580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES969_RS16585	COG1268	BioY protein
ES969_RS16590	COG2056	Na+-H+ antiporter family
ES969_RS16595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES969_RS16600	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES969_RS16610	COG3584	3D domain protein
ES969_RS16625	COG1252	NADH dehydrogenase
ES969_RS16630	COG0492	ferredoxin-NADP+ reductase activity
ES969_RS16640	COG0516	GMP reductase activity
ES969_RS16655	COG0316	Belongs to the HesB IscA family
ES969_RS16660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES969_RS16665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_RS16670	COG4844	belongs to the
ES969_RS16675	COG1252	NADH dehydrogenase
ES969_RS16680	COG4837	Protein of unknown function (DUF1462)
ES969_RS16685	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES969_RS16690	COG0823	Involved in the tonB-independent uptake of proteins
ES969_RS16690	COG4946	Tricorn protease homolog
ES969_RS16690	COG1506	peptidase
ES969_RS16695	COG0083	homoserine kinase activity
ES969_RS16700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES969_RS16705	COG0460	homoserine dehydrogenase
ES969_RS16710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_RS16715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES969_RS16720	COG0647	UMP catabolic process
ES969_RS16725	COG2445	Protein of unknown function DUF86
ES969_RS16730	COG4470	Protein conserved in bacteria
ES969_RS16740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES969_RS16745	COG0739	heme binding
ES969_RS16755	COG3377	Domain of unknown function (DUF1805)
ES969_RS16760	COG0737	Belongs to the 5'-nucleotidase family
ES969_RS16765	COG0730	response to heat
ES969_RS16770	COG1801	Protein of unknown function DUF72
ES969_RS16780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES969_RS16785	COG2508	Transcriptional regulator
ES969_RS16790	COG2233	PERMEase
ES969_RS16795	COG2233	PERMEase
ES969_RS16800	COG3195	allantoin biosynthetic process
ES969_RS16800	COG3648	Uricase
ES969_RS16805	COG2351	hydroxyisourate hydrolase activity
ES969_RS16820	COG2080	2 iron, 2 sulfur cluster binding
ES969_RS16825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES969_RS16830	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES969_RS16840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES969_RS16845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES969_RS16850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_RS16860	COG2356	endonuclease I
ES969_RS16865	COG3842	ATPase activity
ES969_RS16870	COG2188	Transcriptional regulator
ES969_RS16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_RS16880	COG0395	ABC-type sugar transport system, permease component
ES969_RS16885	COG1175	transmembrane transport
ES969_RS16890	COG1653	transport
ES969_RS16895	COG2222	sugar isomerase
ES969_RS16900	COG0322	excinuclease ABC activity
ES969_RS16905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES969_RS16920	COG0346	lactoylglutathione lyase activity
ES969_RS16925	COG0640	Transcriptional regulator
ES969_RS16930	COG0719	Fe-S assembly protein
ES969_RS16935	COG0822	iron-sulfur transferase activity
ES969_RS16940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES969_RS16945	COG0719	Fe-S assembly protein
ES969_RS16950	COG0396	ATPase activity
ES969_RS16965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES969_RS16970	COG1464	Belongs to the NlpA lipoprotein family
ES969_RS16975	COG2011	ABC-type metal ion transport system permease component
ES969_RS16980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES969_RS16990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_RS16995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES969_RS17005	COG0509	glycine decarboxylation via glycine cleavage system
ES969_RS17010	COG1393	Belongs to the ArsC family
ES969_RS17015	COG1960	acyl-CoA dehydrogenase activity
ES969_RS17020	COG0183	Belongs to the thiolase family
ES969_RS17025	COG1024	Enoyl-CoA hydratase
ES969_RS17025	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES969_RS17035	COG0506	proline dehydrogenase activity
ES969_RS17045	COG5577	PFAM Coat F domain
ES969_RS17050	COG1846	Transcriptional regulator
ES969_RS17055	COG0477	Major facilitator Superfamily
ES969_RS17060	COG1942	4-Oxalocrotonate Tautomerase
ES969_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS17070	COG0583	DNA-binding transcription factor activity
ES969_RS17080	COG1120	ATPase activity
ES969_RS17100	COG1131	(ABC) transporter
ES969_RS17145	COG0783	Belongs to the Dps family
ES969_RS17150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_RS17155	COG0745	RESPONSE REGULATOR receiver
ES969_RS17160	COG2770	Histidine kinase
ES969_RS17160	COG2205	protein histidine kinase activity
ES969_RS17170	COG1309	transcriptional regulator
ES969_RS17175	COG0114	fumarate hydratase activity
ES969_RS17185	COG0697	spore germination
ES969_RS17190	COG0814	amino acid
ES969_RS17200	COG2197	response regulator
ES969_RS17205	COG4585	Histidine kinase
ES969_RS17210	COG4758	membrane
ES969_RS17215	COG3595	metallopeptidase activity
ES969_RS17220	COG1842	Phage shock protein A
ES969_RS17225	COG4758	membrane
ES969_RS17230	COG2814	Major facilitator Superfamily
ES969_RS17235	COG2096	Adenosyltransferase
ES969_RS17240	COG1120	ATPase activity
ES969_RS17245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS17250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS17260	COG3386	PFAM SMP-30 Gluconolaconase
ES969_RS17265	COG2205	protein histidine kinase activity
ES969_RS17270	COG0745	RESPONSE REGULATOR receiver
ES969_RS17280	COG1191	sigma factor activity
ES969_RS17290	COG2140	Oxalate decarboxylase
ES969_RS17300	COG0577	efflux transmembrane transporter activity
ES969_RS17305	COG1136	(ABC) transporter
ES969_RS17310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES969_RS17315	COG1120	ATPase activity
ES969_RS17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS17325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_RS17330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS17340	COG0531	amino acid
ES969_RS17355	COG1988	membrane-bound metal-dependent
ES969_RS17360	COG1368	sulfuric ester hydrolase activity
ES969_RS17365	COG1910	domain protein
ES969_RS17370	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES969_RS17375	COG4149	molybdate abc transporter
ES969_RS17380	COG0656	L-ascorbic acid biosynthetic process
ES969_RS17390	COG0025	NhaP-type Na H and K H
ES969_RS17395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_RS17400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_RS17405	COG3973	AAA domain
ES969_RS17415	COG2860	membrane
ES969_RS17420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES969_RS17425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES969_RS17430	COG2217	Heavy metal translocating P-type atpase
ES969_RS17435	COG2217	Heavy metal translocating P-type atpase
ES969_RS17440	COG2608	mercury ion transmembrane transporter activity
ES969_RS17445	COG1937	Protein conserved in bacteria
ES969_RS17450	COG0673	inositol 2-dehydrogenase activity
ES969_RS17460	COG1289	transmembrane transporter activity
ES969_RS17470	COG2076	Multidrug Resistance protein
ES969_RS17475	COG1309	transcriptional regulator
ES969_RS17480	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS17490	COG5444	nuclease activity
ES969_RS17505	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_RS17505	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS17510	COG4824	toxin secretion phage lysis holin
ES969_RS17535	COG3942	CHAP domain
ES969_RS17535	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES969_RS17760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES969_RS17765	COG0557	exoribonuclease II activity
ES969_RS17770	COG1647	Serine aminopeptidase, S33
ES969_RS17775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES969_RS17780	COG0596	Alpha beta hydrolase
ES969_RS17785	COG1476	TRANSCRIPTIONal
ES969_RS17790	COG1396	sequence-specific DNA binding
ES969_RS17795	COG1396	sequence-specific DNA binding
ES969_RS17800	COG1733	regulation of RNA biosynthetic process
ES969_RS17805	COG0840	transmembrane signaling receptor activity
ES969_RS17810	COG1174	glycine betaine transport
ES969_RS17815	COG1732	Glycine betaine
ES969_RS17820	COG1174	glycine betaine transport
ES969_RS17825	COG1125	glycine betaine transport
ES969_RS17825	COG0517	IMP dehydrogenase activity
ES969_RS17830	COG1510	regulation of RNA biosynthetic process
ES969_RS17835	COG1174	glycine betaine transport
ES969_RS17840	COG1732	Glycine betaine
ES969_RS17845	COG1174	glycine betaine transport
ES969_RS17850	COG0517	IMP dehydrogenase activity
ES969_RS17850	COG1125	glycine betaine transport
ES969_RS17855	COG1510	regulation of RNA biosynthetic process
ES969_RS17860	COG2095	MarC family integral membrane protein
ES969_RS17870	COG3064	Membrane
ES969_RS17875	COG4640	response to antibiotic
ES969_RS17880	COG0456	acetyltransferase
ES969_RS17885	COG0148	phosphopyruvate hydratase activity
ES969_RS17890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES969_RS17895	COG0149	triose-phosphate isomerase activity
ES969_RS17900	COG0126	phosphoglycerate kinase activity
ES969_RS17905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES969_RS17910	COG2390	Transcriptional regulator
ES969_RS17915	COG2814	Major facilitator Superfamily
ES969_RS17920	COG1609	Transcriptional regulator
ES969_RS17925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_RS17935	COG0583	DNA-binding transcription factor activity
ES969_RS17940	COG0697	spore germination
ES969_RS17950	COG1113	amino acid transport
ES969_RS17960	COG1556	Lactate utilization protein
ES969_RS17965	COG1139	Iron-sulfur cluster binding protein
ES969_RS17970	COG0247	lactate metabolic process
ES969_RS17975	COG2197	response regulator
ES969_RS17980	COG4585	Histidine kinase
ES969_RS17985	COG0842	Transport permease protein
ES969_RS17990	COG1131	(ABC) transporter
ES969_RS17995	COG0596	Alpha beta hydrolase
ES969_RS18000	COG2208	phosphoserine phosphatase activity
ES969_RS18005	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES969_RS18010	COG1874	Beta-galactosidase
ES969_RS18015	COG3833	ABC-type maltose transport systems, permease component
ES969_RS18020	COG1175	transmembrane transport
ES969_RS18025	COG2182	Extracellular solute-binding protein
ES969_RS18030	COG1609	Transcriptional regulator
ES969_RS18035	COG2186	Transcriptional regulator
ES969_RS18040	COG1620	l-lactate permease
ES969_RS18045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES969_RS18055	COG5039	Polysaccharide pyruvyl transferase
ES969_RS18060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_RS18065	COG0110	maltose O-acetyltransferase activity
ES969_RS18070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES969_RS18075	COG2244	polysaccharide biosynthetic process
ES969_RS18080	COG1216	Glycosyl transferase, family 2
ES969_RS18085	COG5039	Polysaccharide pyruvyl transferase
ES969_RS18090	COG1216	Glycosyl transferase, family 2
ES969_RS18100	COG0438	transferase activity, transferring glycosyl groups
ES969_RS18105	COG1215	transferase activity, transferring glycosyl groups
ES969_RS18110	COG0438	transferase activity, transferring glycosyl groups
ES969_RS18115	COG1086	Polysaccharide biosynthesis protein
ES969_RS18120	COG0489	protein tyrosine kinase activity
ES969_RS18125	COG3944	biosynthesis protein
ES969_RS18130	COG1396	sequence-specific DNA binding
ES969_RS18135	COG2272	Belongs to the type-B carboxylesterase lipase family
ES969_RS18145	COG3479	Phenolic acid decarboxylase
ES969_RS18160	COG1794	racemase activity, acting on amino acids and derivatives
ES969_RS18170	COG1621	beta-fructofuranosidase activity
ES969_RS18175	COG1621	beta-fructofuranosidase activity
ES969_RS18180	COG0531	amino acid
ES969_RS18185	COG1309	transcriptional regulator
ES969_RS18190	COG2076	Multidrug Resistance protein
ES969_RS18195	COG2076	Multidrug Resistance protein
ES969_RS18210	COG0740	serine-type endopeptidase activity
ES969_RS18215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES969_RS18220	COG0366	Alpha amylase catalytic
ES969_RS18225	COG1554	hydrolase, family 65, central catalytic
ES969_RS18230	COG5521	maltodextrose utilization protein MalA
ES969_RS18235	COG3833	ABC-type maltose transport systems, permease component
ES969_RS18240	COG1175	transmembrane transport
ES969_RS18255	COG1609	Transcriptional regulator
ES969_RS18260	COG1611	Belongs to the LOG family
ES969_RS18270	COG0659	secondary active sulfate transmembrane transporter activity
ES969_RS18275	COG0288	reversible hydration of carbon dioxide
ES969_RS18280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES969_RS18285	COG0577	efflux transmembrane transporter activity
ES969_RS18290	COG1136	(ABC) transporter
ES969_RS18295	COG5002	protein histidine kinase activity
ES969_RS18300	COG0745	RESPONSE REGULATOR receiver
ES969_RS18310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES969_RS18315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS18320	COG1481	regulation of sporulation
ES969_RS18325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES969_RS18330	COG1660	Displays ATPase and GTPase activities
ES969_RS18335	COG1051	belongs to the nudix hydrolase family
ES969_RS18340	COG0492	ferredoxin-NADP+ reductase activity
ES969_RS18345	COG0791	NLP P60 protein
ES969_RS18345	COG3883	PFAM NLP P60 protein
ES969_RS18350	COG0457	Tetratricopeptide repeat
ES969_RS18355	COG1132	(ABC) transporter
ES969_RS18375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES969_RS18375	COG0140	phosphoribosyl-ATP diphosphatase activity
ES969_RS18380	COG0107	imidazoleglycerol-phosphate synthase activity
ES969_RS18385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES969_RS18390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES969_RS18395	COG0131	Imidazoleglycerol-phosphate dehydratase
ES969_RS18400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES969_RS18405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES969_RS18410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES969_RS18415	COG4990	cell redox homeostasis
ES969_RS18420	COG5297	Belongs to the glycosyl hydrolase family 6
ES969_RS18425	COG0110	maltose O-acetyltransferase activity
ES969_RS18430	COG0546	phosphoglycolate phosphatase activity
ES969_RS18435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES969_RS18440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES969_RS18445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES969_RS18450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES969_RS18455	COG0363	glucosamine-6-phosphate deaminase activity
ES969_RS18460	COG2188	Transcriptional regulator
ES969_RS18465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES969_RS18470	COG1950	PFAM Membrane protein of
ES969_RS18475	COG1983	PspC domain protein
ES969_RS18480	COG3595	metallopeptidase activity
ES969_RS18495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_RS18500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES969_RS18505	COG0556	nucleotide-excision repair
ES969_RS18510	COG4897	Protein conserved in bacteria
ES969_RS18515	COG0574	Belongs to the PEP-utilizing enzyme family
ES969_RS18515	COG3848	Pyruvate phosphate dikinase
ES969_RS18525	COG2814	Major facilitator Superfamily
ES969_RS18530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_RS18540	COG0793	Belongs to the peptidase S41A family
ES969_RS18540	COG3409	Peptidoglycan-binding domain 1 protein
ES969_RS18545	COG2177	Part of the ABC transporter FtsEX involved in
ES969_RS18550	COG2884	Cell division ATP-binding protein ftsE
ES969_RS18555	COG2010	Cytochrome c
ES969_RS18560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS18570	COG0653	protein targeting
ES969_RS18580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES969_RS18595	COG1516	flagellar protein fliS
ES969_RS18600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES969_RS18605	COG1334	flagellar protein FlaG
ES969_RS18610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_RS18615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES969_RS18620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES969_RS18630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_RS18635	COG4786	Flagellar basal body rod
ES969_RS18635	COG1256	bacterial-type flagellum assembly
ES969_RS18640	COG3418	PFAM FlgN family protein
ES969_RS18645	COG2747	anti-sigma28 factor FlgM
ES969_RS18655	COG1040	competence protein
ES969_RS18665	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES969_RS18670	COG1307	EDD domain protein, DegV family
ES969_RS18675	COG2197	response regulator
ES969_RS18680	COG4585	Histidine kinase
ES969_RS18685	COG1739	Uncharacterized protein family UPF0029
ES969_RS18690	COG1316	TRANSCRIPTIONal
ES969_RS18725	COG1131	(ABC) transporter
ES969_RS18735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES969_RS18740	COG0438	transferase activity, transferring glycosyl groups
ES969_RS18745	COG1215	transferase activity, transferring glycosyl groups
ES969_RS18750	COG3206	protein involved in exopolysaccharide biosynthesis
ES969_RS18755	COG3307	-O-antigen
ES969_RS18765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_RS18770	COG0297	glycogen (starch) synthase activity
ES969_RS18770	COG0438	transferase activity, transferring glycosyl groups
ES969_RS18775	COG2244	polysaccharide biosynthetic process
ES969_RS18785	COG2247	cell wall binding repeat
ES969_RS18785	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_RS18790	COG2247	cell wall binding repeat
ES969_RS18790	COG2385	sporulation resulting in formation of a cellular spore
ES969_RS18805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES969_RS18810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES969_RS18820	COG1134	teichoic acid transport
ES969_RS18825	COG1682	transport, permease protein
ES969_RS18840	COG0463	Glycosyl transferase, family 2
ES969_RS18840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_RS18845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_RS18850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES969_RS18855	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES969_RS18860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_RS18865	COG4193	domain, Protein
ES969_RS18870	COG1482	cell wall glycoprotein biosynthetic process
ES969_RS18875	COG0697	spore germination
ES969_RS18880	COG0814	amino acid
ES969_RS18895	COG1316	TRANSCRIPTIONal
ES969_RS18900	COG0561	phosphatase activity
ES969_RS18905	COG0791	NLP P60 protein
ES969_RS18915	COG2843	Capsule synthesis protein
ES969_RS18925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES969_RS18930	COG1609	Transcriptional regulator
ES969_RS18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_RS18940	COG1869	D-ribose catabolic process
ES969_RS18945	COG1129	ABC transporter
ES969_RS18950	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES969_RS18955	COG1879	ABC-type sugar transport system periplasmic component
ES969_RS18960	COG3103	Sh3 type 3 domain protein
ES969_RS18970	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES969_RS18975	COG3527	Alpha-acetolactate decarboxylase
ES969_RS18980	COG0028	Belongs to the TPP enzyme family
ES969_RS18985	COG0583	DNA-binding transcription factor activity
ES969_RS18990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES969_RS19005	COG5337	Spore coat protein CotH
ES969_RS19015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES969_RS19025	COG0405	Gamma-glutamyltransferase
ES969_RS19030	COG1522	sequence-specific DNA binding
ES969_RS19035	COG2059	Chromate
ES969_RS19040	COG2059	Chromate
ES969_RS19050	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES969_RS19085	COG5444	nuclease activity
ES969_RS19110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_RS19115	COG4464	protein tyrosine phosphatase activity
ES969_RS19120	COG0489	protein tyrosine kinase activity
ES969_RS19125	COG3944	biosynthesis protein
ES969_RS19135	COG4715	Zinc finger, swim domain protein
ES969_RS19140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES969_RS19145	COG0561	phosphatase activity
ES969_RS19150	COG1349	DNA-binding transcription factor activity
ES969_RS19155	COG0629	single-stranded DNA binding
ES969_RS19170	COG3764	Sortase (surface protein transpeptidase)
ES969_RS19185	COG1970	mechanosensitive ion channel activity
ES969_RS19190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES969_RS19195	COG0457	Tetratricopeptide repeat
ES969_RS19200	COG4786	Flagellar basal body rod
ES969_RS19205	COG4786	Flagellar basal body rod
ES969_RS19210	COG1077	Cell shape determining protein MreB Mrl
ES969_RS19215	COG1609	Transcriptional regulator
ES969_RS19225	COG1846	Transcriptional regulator
ES969_RS19230	COG2814	Major facilitator Superfamily
ES969_RS19235	COG3420	alginic acid biosynthetic process
ES969_RS19240	COG1953	Uracil, thiamine, allantoin
ES969_RS19245	COG0477	Major facilitator Superfamily
ES969_RS19250	COG1335	isochorismatase
ES969_RS19260	COG0004	ammonium transporteR
ES969_RS19265	COG0347	Belongs to the P(II) protein family
ES969_RS19270	COG0671	phosphoesterase, PA-phosphatase related
ES969_RS19280	COG0739	heme binding
ES969_RS19285	COG1247	-acetyltransferase
ES969_RS19295	COG2089	acid synthase
ES969_RS19305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_RS19310	COG0789	Transcriptional regulator
ES969_RS19320	COG2910	NAD(P)H-binding
ES969_RS19325	COG1959	2 iron, 2 sulfur cluster binding
ES969_RS19330	COG0804	urea catabolic process
ES969_RS19335	COG0832	Belongs to the urease beta subunit family
ES969_RS19340	COG0831	urea catabolic process
ES969_RS19355	COG3237	CsbD-like
ES969_RS19360	COG1994	Peptidase M50
ES969_RS19365	COG0457	Tetratricopeptide repeat
ES969_RS19370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES969_RS19375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES969_RS19385	COG2304	oxidoreductase activity
ES969_RS19395	COG2304	oxidoreductase activity
ES969_RS19400	COG2385	sporulation resulting in formation of a cellular spore
ES969_RS19405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES969_RS19415	COG4836	Membrane
ES969_RS19425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES969_RS19430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES969_RS19435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES969_RS19440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES969_RS19445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES969_RS19450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES969_RS19460	COG0356	it plays a direct role in the translocation of protons across the membrane
ES969_RS19470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES969_RS19475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES969_RS19480	COG4475	Protein of unknown function (DUF436)
ES969_RS19485	COG0698	ribose 5-phosphate isomerase
ES969_RS19490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES969_RS19495	COG1971	Probably functions as a manganese efflux pump
ES969_RS19500	COG0009	L-threonylcarbamoyladenylate synthase
ES969_RS19505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES969_RS19525	COG2890	protein-(glutamine-N5) methyltransferase activity
ES969_RS19530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES969_RS19535	COG0346	lactoylglutathione lyase activity
ES969_RS19540	COG0789	Transcriptional regulator
ES969_RS19545	COG0679	Auxin Efflux Carrier
ES969_RS19550	COG0281	malic enzyme
ES969_RS19555	COG1435	thymidine kinase activity
ES969_RS19565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES969_RS19575	COG1494	fructose-1,6-bisphosphatase
ES969_RS19580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES969_RS19585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES969_RS19590	COG0191	fructose-bisphosphate aldolase activity
ES969_RS19595	COG2204	response regulator
ES969_RS19610	COG0504	CTP synthase activity
ES969_RS19615	COG3343	RNA polymerase activity
ES969_RS19620	COG1960	acyl-CoA dehydrogenase activity
ES969_RS19625	COG0247	lactate metabolic process
ES969_RS19625	COG2181	nitrate reductase activity
ES969_RS19630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_RS19635	COG4294	response to UV
ES969_RS19650	COG0018	arginyl-trna synthetase
ES969_RS19655	COG4506	Protein conserved in bacteria
ES969_RS19670	COG0535	radical SAM domain protein
ES969_RS19680	COG1131	(ABC) transporter
ES969_RS19685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES969_RS19690	COG0612	Peptidase, M16
ES969_RS19695	COG0612	Peptidase, M16
ES969_RS19705	COG3391	amine dehydrogenase activity
ES969_RS19720	COG0457	Tetratricopeptide repeat
ES969_RS19735	COG0010	Belongs to the arginase family
ES969_RS19740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES969_RS19745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_RS19760	COG1994	Peptidase M50
ES969_RS19765	COG1942	4-Oxalocrotonate Tautomerase
ES969_RS19770	COG1846	Transcriptional regulator
ES969_RS19775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES969_RS19785	COG0477	Major facilitator Superfamily
ES969_RS19790	COG1959	2 iron, 2 sulfur cluster binding
ES969_RS19795	COG3465	dGTPase activity
ES969_RS19800	COG1078	dGTPase activity
ES969_RS19805	COG4844	belongs to the
ES969_RS19815	COG0697	spore germination
ES969_RS19820	COG0095	Lipoate-protein ligase
ES969_RS19825	COG0583	DNA-binding transcription factor activity
ES969_RS19830	COG0280	phosphate acetyltransferase
ES969_RS19835	COG3253	May function as heme-dependent peroxidase
ES969_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS19845	COG0436	Aminotransferase
ES969_RS19850	COG2814	Major facilitator Superfamily
ES969_RS19855	COG0151	Belongs to the GarS family
ES969_RS19860	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS19865	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS19870	COG0077	Prephenate dehydratase
ES969_RS19875	COG2814	Major facilitator Superfamily
ES969_RS19880	COG0833	amino acid
ES969_RS19885	COG4187	Peptidase family M20/M25/M40
ES969_RS19890	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS19895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_RS19905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES969_RS19910	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES969_RS19915	COG1088	dTDP-glucose 4,6-dehydratase activity
ES969_RS19920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES969_RS19925	COG3980	spore coat polysaccharide biosynthesis protein
ES969_RS19930	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES969_RS19935	COG2089	acid synthase
ES969_RS19940	COG0456	acetyltransferase
ES969_RS19945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_RS19950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_RS19955	COG0463	Glycosyl transferase, family 2
ES969_RS19970	COG2363	Small membrane protein
ES969_RS19975	COG2233	PERMEase
ES969_RS19985	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS19990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES969_RS19995	COG1216	Glycosyl transferase, family 2
ES969_RS20000	COG0351	phosphomethylpyrimidine kinase
ES969_RS20010	COG1621	beta-fructofuranosidase activity
ES969_RS20015	COG1263	PTS System
ES969_RS20015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS20020	COG2116	formate transmembrane transporter activity
ES969_RS20025	COG3711	transcriptional antiterminator
ES969_RS20035	COG1404	Belongs to the peptidase S8 family
ES969_RS20040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_RS20045	COG0778	Nitroreductase
ES969_RS20050	COG0772	Belongs to the SEDS family
ES969_RS20065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES969_RS20070	COG1845	cytochrome c oxidase, subunit III
ES969_RS20075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES969_RS20080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES969_RS20085	COG2261	transglycosylase associated protein
ES969_RS20090	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES969_RS20095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES969_RS20100	COG2246	polysaccharide biosynthetic process
ES969_RS20105	COG1309	transcriptional regulator
ES969_RS20115	COG3162	membrane
ES969_RS20120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_RS20125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES969_RS20130	COG2837	iron assimilation
ES969_RS20135	COG2822	iron ion transport
ES969_RS20140	COG0672	)-iron permease
ES969_RS20145	COG0352	thiamine-phosphate diphosphorylase activity
ES969_RS20150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES969_RS20155	COG0583	DNA-binding transcription factor activity
ES969_RS20160	COG1380	Effector of murein hydrolase LrgA
ES969_RS20165	COG1346	cytolysis
ES969_RS20170	COG2814	Major facilitator Superfamily
ES969_RS20175	COG4895	conserved protein (DUF2196)
ES969_RS20180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES969_RS20185	COG0346	lactoylglutathione lyase activity
ES969_RS20195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_RS20200	COG1404	Belongs to the peptidase S8 family
ES969_RS20205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_RS20205	COG1263	PTS System
ES969_RS20210	COG3711	transcriptional antiterminator
ES969_RS20215	COG1442	glycosyl transferase family 8
ES969_RS20220	COG5522	Integral membrane protein (intg_mem_TP0381)
ES969_RS20225	COG1846	Transcriptional regulator
ES969_RS20230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES969_RS20235	COG2234	aminopeptidase activity
ES969_RS20240	COG2357	RelA SpoT domain protein
ES969_RS20250	COG1575	Belongs to the MenA family. Type 1 subfamily
ES969_RS20270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_RS20275	COG1696	Membrane protein involved in D-alanine export
ES969_RS20280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES969_RS20285	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES969_RS20295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_RS20300	COG1486	melibiose metabolic process
ES969_RS20305	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES969_RS20310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_RS20315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_RS20320	COG3711	transcriptional antiterminator
ES969_RS20320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_RS20330	COG2094	Belongs to the DNA glycosylase MPG family
ES969_RS20335	COG0753	catalase activity
ES969_RS20345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_RS20350	COG1131	(ABC) transporter
ES969_RS20370	COG1595	DNA-templated transcription, initiation
ES969_RS20375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES969_RS20380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES969_RS20385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES969_RS20390	COG4988	ABC transporter
ES969_RS20395	COG1294	oxidase, subunit
ES969_RS20400	COG1271	oxidase subunit
ES969_RS20405	COG3493	citrate carrier protein
ES969_RS20410	COG0501	Belongs to the peptidase M48B family
ES969_RS20420	COG0726	polysaccharide deacetylase
ES969_RS20425	COG3842	ATPase activity
ES969_RS20430	COG2508	Transcriptional regulator
ES969_RS20435	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS20440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_RS20445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES969_RS20455	COG4585	Histidine kinase
ES969_RS20460	COG2197	response regulator
ES969_RS20465	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES969_RS20475	COG4894	glucomannan catabolic process
ES969_RS20480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_RS20485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS20495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES969_RS20505	COG2610	gluconate transmembrane transporter activity
ES969_RS20510	COG0500	methyltransferase
ES969_RS20515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_RS20530	COG0693	protein deglycase activity
ES969_RS20530	COG0753	catalase activity
ES969_RS20535	COG2851	Citrate transporter
ES969_RS20540	COG2273	Hydrolase Family 16
ES969_RS20545	COG3711	transcriptional antiterminator
ES969_RS20560	COG2270	Major facilitator Superfamily
ES969_RS20565	COG0513	Belongs to the DEAD box helicase family
ES969_RS20570	COG2755	lipolytic protein G-D-S-L family
ES969_RS20570	COG3401	FG-GAP repeat protein
ES969_RS20700	COG0589	response to stress
ES969_RS20720	COG5444	nuclease activity
ES969_RS20735	COG3507	Belongs to the glycosyl hydrolase 43 family
ES969_RS20750	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES969_RS20755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_RS20760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES969_RS20765	COG2390	Transcriptional regulator
ES969_RS20775	COG3192	ethanolamine utilization protein
ES969_RS20780	COG2079	MmgE PrpD family protein
ES969_RS20785	COG1473	amidohydrolase
ES969_RS20790	COG1126	abc transporter atp-binding protein
ES969_RS20795	COG0765	amino acid transport
ES969_RS20800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_RS20805	COG0456	acetyltransferase
ES969_RS20810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_RS20815	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES969_RS20820	COG0561	phosphatase activity
ES969_RS20850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_RS20855	COG5294	Protein conserved in bacteria
ES969_RS20860	COG0577	efflux transmembrane transporter activity
ES969_RS20865	COG1136	(ABC) transporter
ES969_RS20870	COG2205	protein histidine kinase activity
ES969_RS20880	COG0191	fructose-bisphosphate aldolase activity
ES969_RS20885	COG1082	Xylose isomerase domain protein TIM barrel
ES969_RS20890	COG1082	Xylose isomerase domain protein TIM barrel
ES969_RS20895	COG0673	inositol 2-dehydrogenase activity
ES969_RS20900	COG2814	Major facilitator Superfamily
ES969_RS20905	COG1082	Xylose isomerase domain protein TIM barrel
ES969_RS20910	COG3962	Belongs to the TPP enzyme family
ES969_RS20915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_RS20930	COG1349	DNA-binding transcription factor activity
ES969_RS20935	COG0667	Aldo Keto reductase
ES969_RS20960	COG2814	Major facilitator Superfamily
ES969_RS20965	COG0326	Molecular chaperone. Has ATPase activity
ES969_RS20980	COG1309	transcriptional regulator
ES969_RS20985	COG1012	belongs to the aldehyde dehydrogenase family
ES969_RS20990	COG1714	RDD family
ES969_RS21000	COG1714	RDD family
ES969_RS21005	COG2311	Membrane
ES969_RS21010	COG1917	Cupin 2, conserved barrel domain protein
ES969_RS21015	COG1309	transcriptional regulator
ES969_RS21020	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_RS21025	COG1846	Transcriptional regulator
ES969_RS21030	COG1380	Effector of murein hydrolase LrgA
ES969_RS21035	COG1346	cytolysis
ES969_RS21040	COG5039	Polysaccharide pyruvyl transferase
ES969_RS21045	COG1929	Belongs to the glycerate kinase type-1 family
ES969_RS21050	COG1802	Transcriptional regulator
ES969_RS21055	COG1070	Carbohydrate kinase
ES969_RS21060	COG2610	gluconate transmembrane transporter activity
ES969_RS21065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES969_RS21070	COG0450	alkyl hydroperoxide reductase
ES969_RS21075	COG3634	alkyl hydroperoxide reductase activity
ES969_RS21080	COG2723	6-phospho-beta-galactosidase activity
ES969_RS21095	COG2188	Transcriptional regulator
ES969_RS21105	COG1131	(ABC) transporter
ES969_RS21110	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES969_RS21115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES969_RS21140	COG1401	restriction endodeoxyribonuclease activity
ES969_RS21170	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES969_RS21175	COG0456	acetyltransferase
ES969_RS21180	COG0457	Tetratricopeptide repeat
ES969_RS21190	COG0010	Belongs to the arginase family
ES969_RS21195	COG0833	amino acid
ES969_RS21200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES969_RS21220	COG5658	integral membrane protein
ES969_RS21225	COG0640	Transcriptional regulator
ES969_RS21230	COG3829	transcription factor binding
ES969_RS21245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_RS21250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES969_RS21255	COG4853	Protein conserved in bacteria
ES969_RS21260	COG4863	YycH protein
ES969_RS21265	COG5002	protein histidine kinase activity
ES969_RS21270	COG0745	RESPONSE REGULATOR receiver
ES969_RS21300	COG0346	lactoylglutathione lyase activity
ES969_RS21305	COG0305	Participates in initiation and elongation during chromosome replication
ES969_RS21320	COG3093	addiction module antidote protein HigA
ES969_RS21325	COG2807	transmembrane transport
ES969_RS21330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES969_RS21335	COG0359	binds to the 23S rRNA
ES969_RS21340	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES969_RS21345	COG4241	membrane
ES969_RS21360	COG1733	regulation of RNA biosynthetic process
ES969_RS21365	COG1227	inorganic diphosphatase activity
ES969_RS21380	COG2271	Major facilitator Superfamily
ES969_RS21385	COG0789	Transcriptional regulator
ES969_RS21385	COG4978	Transcriptional regulator
ES969_RS21395	COG4319	ketosteroid isomerase
ES969_RS21400	COG1357	PFAM Pentapeptide repeats (8 copies)
ES969_RS21415	COG1846	Transcriptional regulator
ES969_RS21420	COG2153	protein acetylation
ES969_RS21425	COG2364	Membrane
ES969_RS21430	COG0456	acetyltransferase
ES969_RS21440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES969_RS21450	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ES969_RS21455	COG1331	Highly conserved protein containing a thioredoxin domain
ES969_RS21460	COG1266	CAAX protease self-immunity
ES969_RS21465	COG2814	Major facilitator Superfamily
ES969_RS21465	COG0477	Major facilitator Superfamily
ES969_RS21470	COG0346	lactoylglutathione lyase activity
ES969_RS21475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_RS21480	COG0542	response to heat
ES969_RS21495	COG0708	Exodeoxyribonuclease III
ES969_RS21500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES969_RS21505	COG0629	single-stranded DNA binding
ES969_RS21510	COG0360	Binds together with S18 to 16S ribosomal RNA
ES969_RS21515	COG0012	GTP binding
ES969_RS21520	COG0243	molybdopterin cofactor binding
ES969_RS21525	COG4481	Protein conserved in bacteria
ES969_RS21530	COG3949	Membrane
ES969_RS21540	COG1475	DNA binding
ES969_RS21545	COG1192	Involved in chromosome partitioning
ES969_RS21555	COG1475	DNA binding
ES969_RS21560	COG0357	Ribosomal RNA small subunit methyltransferase G
ES969_RS21565	COG0445	tRNA wobble uridine modification
ES969_RS21570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES969_RS21575	COG1847	R3H domain protein
ES969_RS21580	COG0706	membrane insertase activity
ES969_RS21585	COG0594	ribonuclease P activity