locus-tag	class	description
ETK61_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ETK61_RS00010	COG0592	DNA-directed DNA polymerase activity
ETK61_RS00015	COG2501	S4 domain
ETK61_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ETK61_RS00030	COG0187	DNA topoisomerase II activity
ETK61_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ETK61_RS00070	COG0517	IMP dehydrogenase activity
ETK61_RS00070	COG0516	GMP reductase activity
ETK61_RS00075	COG1686	Belongs to the peptidase S11 family
ETK61_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ETK61_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ETK61_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ETK61_RS00100	COG1428	Deoxynucleoside kinase
ETK61_RS00105	COG1428	Deoxynucleoside kinase
ETK61_RS00110	COG3858	chitin binding
ETK61_RS00110	COG1388	LysM domain
ETK61_RS00115	COG1335	isochorismatase
ETK61_RS00120	COG0590	tRNA wobble adenosine to inosine editing
ETK61_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ETK61_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ETK61_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ETK61_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ETK61_RS00190	COG3853	Toxic anion resistance protein (TelA)
ETK61_RS00195	COG1982	Orn Lys Arg decarboxylase major
ETK61_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ETK61_RS00205	COG3870	Protein conserved in bacteria
ETK61_RS00210	COG1728	Protein conserved in bacteria
ETK61_RS00215	COG0470	DNA polymerase III
ETK61_RS00220	COG1774	PSP1 C-terminal conserved region
ETK61_RS00225	COG4467	Involved in initiation control of chromosome replication
ETK61_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ETK61_RS00235	COG2827	Endonuclease containing a URI domain
ETK61_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ETK61_RS00245	COG2002	toxin-antitoxin pair type II binding
ETK61_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS00255	COG0084	hydrolase, TatD family'
ETK61_RS00260	COG3583	domain protein
ETK61_RS00260	COG3584	3D domain protein
ETK61_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ETK61_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ETK61_RS00280	COG4466	Protein conserved in bacteria
ETK61_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ETK61_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK61_RS00300	COG0251	oxidation-reduction process
ETK61_RS00305	COG2088	sporulation resulting in formation of a cellular spore
ETK61_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ETK61_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ETK61_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ETK61_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
ETK61_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ETK61_RS00340	COG2002	toxin-antitoxin pair type II binding
ETK61_RS00345	COG2244	polysaccharide biosynthetic process
ETK61_RS00350	COG3956	TIGRFAM MazG family protein
ETK61_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ETK61_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ETK61_RS00375	COG1098	S1 RNA binding domain
ETK61_RS00390	COG2208	phosphoserine phosphatase activity
ETK61_RS00395	COG2304	oxidoreductase activity
ETK61_RS00400	COG0515	serine threonine protein kinase
ETK61_RS00405	COG0037	tRNA processing
ETK61_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ETK61_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETK61_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ETK61_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ETK61_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETK61_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK61_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETK61_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ETK61_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK61_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ETK61_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ETK61_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ETK61_RS00470	COG1396	sequence-specific DNA binding
ETK61_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ETK61_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ETK61_RS00560	COG4463	regulation of RNA biosynthetic process
ETK61_RS00565	COG3880	PFAM UvrB UvrC protein
ETK61_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ETK61_RS00575	COG0542	response to heat
ETK61_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ETK61_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ETK61_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
ETK61_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ETK61_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ETK61_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ETK61_RS00615	COG1045	serine acetyltransferase
ETK61_RS00620	COG0215	cysteine-tRNA ligase activity
ETK61_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ETK61_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETK61_RS00635	COG3688	RNA-binding protein containing a PIN domain
ETK61_RS00640	COG1595	DNA-templated transcription, initiation
ETK61_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ETK61_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
ETK61_RS00665	COG0081	regulation of translation
ETK61_RS00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ETK61_RS00680	COG2813	Specifically methylates the guanine in position
ETK61_RS00685	COG0085	RNA polymerase activity
ETK61_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ETK61_RS00695	COG1358	cellular component organization or biogenesis
ETK61_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ETK61_RS00705	COG0049	tRNA binding
ETK61_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ETK61_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ETK61_RS00720	COG0596	Alpha beta hydrolase
ETK61_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ETK61_RS00735	COG0088	Forms part of the polypeptide exit tunnel
ETK61_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ETK61_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ETK61_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ETK61_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ETK61_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ETK61_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ETK61_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ETK61_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ETK61_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ETK61_RS00825	COG0200	Binds to the 23S rRNA
ETK61_RS00830	COG0201	protein transport
ETK61_RS00835	COG0563	adenylate kinase activity
ETK61_RS00840	COG0024	Methionine aminopeptidase
ETK61_RS00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ETK61_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ETK61_RS00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ETK61_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ETK61_RS00870	COG0202	RNA polymerase activity
ETK61_RS00875	COG0203	ribosomal protein L17
ETK61_RS00880	COG1122	ATPase activity
ETK61_RS00885	COG1122	ATPase activity
ETK61_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ETK61_RS00895	COG0101	tRNA pseudouridine synthase activity
ETK61_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ETK61_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ETK61_RS00910	COG2226	methyltransferase
ETK61_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS00925	COG0489	protein tyrosine kinase activity
ETK61_RS00935	COG2194	sulfuric ester hydrolase activity
ETK61_RS00940	COG0726	polysaccharide deacetylase
ETK61_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
ETK61_RS01030	COG0385	Bile acid
ETK61_RS01035	COG2819	hydrolase of the alpha beta superfamily
ETK61_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS01055	COG2207	Transcriptional regulator
ETK61_RS01060	COG3876	Protein conserved in bacteria
ETK61_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ETK61_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK61_RS01075	COG1263	PTS System
ETK61_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS01080	COG1737	Transcriptional regulator
ETK61_RS01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ETK61_RS01095	COG1683	Conserved Protein
ETK61_RS01125	COG1595	DNA-templated transcription, initiation
ETK61_RS01130	COG5662	AntiSigma factor
ETK61_RS01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ETK61_RS01140	COG4856	YbbR-like protein
ETK61_RS01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETK61_RS01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ETK61_RS01180	COG1063	alcohol dehydrogenase
ETK61_RS01190	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS01210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ETK61_RS01220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ETK61_RS01225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETK61_RS01230	COG3002	Belongs to the UPF0753 family
ETK61_RS01235	COG0288	reversible hydration of carbon dioxide
ETK61_RS01245	COG5609	conserved protein (DUF2294)
ETK61_RS01250	COG0640	Transcriptional regulator
ETK61_RS01255	COG2814	Major facilitator Superfamily
ETK61_RS01270	COG0596	Alpha beta hydrolase
ETK61_RS01275	COG0745	RESPONSE REGULATOR receiver
ETK61_RS01280	COG0642	Histidine kinase
ETK61_RS01290	COG0515	serine threonine protein kinase
ETK61_RS01305	COG1113	amino acid transport
ETK61_RS01320	COG2602	Beta-lactamase
ETK61_RS01325	COG2124	cytochrome p450
ETK61_RS01335	COG0531	amino acid
ETK61_RS01345	COG0584	glycerophosphoryl diester phosphodiesterase
ETK61_RS01350	COG2271	Major facilitator Superfamily
ETK61_RS01365	COG0456	acetyltransferase
ETK61_RS01365	COG1846	Transcriptional regulator
ETK61_RS01370	COG2271	Major facilitator Superfamily
ETK61_RS01380	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS01385	COG0697	spore germination
ETK61_RS01390	COG2207	Transcriptional regulator
ETK61_RS01390	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS01395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ETK61_RS01400	COG3591	Belongs to the peptidase S1B family
ETK61_RS01410	COG0596	Alpha beta hydrolase
ETK61_RS01415	COG1183	phosphatidylcholine synthase activity
ETK61_RS01420	COG0586	Pfam SNARE associated Golgi protein
ETK61_RS01425	COG0688	phosphatidylethanolamine metabolic process
ETK61_RS01435	COG1054	Belongs to the UPF0176 family
ETK61_RS01440	COG1301	dicarboxylic acid transport
ETK61_RS01445	COG2190	(PTS) system
ETK61_RS01445	COG1263	PTS System
ETK61_RS01445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS01450	COG0363	glucosamine-6-phosphate deaminase activity
ETK61_RS01455	COG2188	Transcriptional regulator
ETK61_RS01465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK61_RS01470	COG0833	amino acid
ETK61_RS01475	COG2040	homocysteine
ETK61_RS01485	COG1115	amino acid carrier protein
ETK61_RS01490	COG2066	Belongs to the glutaminase family
ETK61_RS01500	COG0784	Response regulator, receiver
ETK61_RS01510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETK61_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS01520	COG2271	Major facilitator Superfamily
ETK61_RS01525	COG4948	Mandelate Racemase Muconate Lactonizing
ETK61_RS01530	COG2186	Transcriptional regulator
ETK61_RS01540	COG3173	Aminoglycoside phosphotransferase
ETK61_RS01550	COG0697	spore germination
ETK61_RS01555	COG0745	RESPONSE REGULATOR receiver
ETK61_RS01560	COG2205	protein histidine kinase activity
ETK61_RS01565	COG1131	(ABC) transporter
ETK61_RS01585	COG3773	Cell wall hydrolase
ETK61_RS01590	COG2304	oxidoreductase activity
ETK61_RS01600	COG3540	Alkaline phosphatase
ETK61_RS01605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETK61_RS01610	COG0805	protein transport
ETK61_RS01615	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ETK61_RS01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ETK61_RS01625	COG0477	Major facilitator Superfamily
ETK61_RS01630	COG1309	transcriptional regulator
ETK61_RS01635	COG0252	asparaginase activity
ETK61_RS01640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ETK61_RS01645	COG1714	RDD family
ETK61_RS01650	COG1405	negative regulation of cell septum assembly
ETK61_RS01650	COG3012	SEC-C Motif Domain Protein
ETK61_RS01675	COG0667	Aldo Keto reductase
ETK61_RS01690	COG1595	DNA-templated transcription, initiation
ETK61_RS01695	COG1595	DNA-templated transcription, initiation
ETK61_RS01700	COG1876	peptidase activity
ETK61_RS01705	COG0457	Tetratricopeptide repeat
ETK61_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS01715	COG0366	Alpha amylase catalytic
ETK61_RS01720	COG0803	Belongs to the bacterial solute-binding protein 9 family
ETK61_RS01725	COG1121	(ABC) transporter
ETK61_RS01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETK61_RS01735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS01740	COG2310	stress, protein
ETK61_RS01745	COG2310	stress, protein
ETK61_RS01750	COG2310	stress, protein
ETK61_RS01755	COG0861	Integral membrane protein TerC family
ETK61_RS01765	COG3853	Toxic anion resistance protein (TelA)
ETK61_RS01770	COG0477	Major facilitator Superfamily
ETK61_RS01780	COG2814	Major facilitator Superfamily
ETK61_RS01785	COG0640	Transcriptional regulator
ETK61_RS01790	COG0517	IMP dehydrogenase activity
ETK61_RS01790	COG4175	Glycine betaine
ETK61_RS01795	COG4176	ABC-type proline glycine betaine transport system permease component
ETK61_RS01800	COG2113	Glycine betaine
ETK61_RS01805	COG1473	amidohydrolase
ETK61_RS01810	COG1288	antiporter activity
ETK61_RS01825	COG0039	L-malate dehydrogenase activity
ETK61_RS01830	COG1620	l-lactate permease
ETK61_RS01840	COG3403	YqcI/YcgG family
ETK61_RS01855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ETK61_RS01865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ETK61_RS01870	COG2226	methyltransferase
ETK61_RS01875	COG0583	DNA-binding transcription factor activity
ETK61_RS01880	COG3458	cephalosporin-C deacetylase activity
ETK61_RS01885	COG3541	Predicted nucleotidyltransferase
ETK61_RS01890	COG0506	proline dehydrogenase activity
ETK61_RS01895	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS01900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK61_RS01905	COG2508	Transcriptional regulator
ETK61_RS01910	COG3689	TIGRFAM TIGR03943 family protein
ETK61_RS01915	COG0701	Predicted permease
ETK61_RS01920	COG2267	carboxylic ester hydrolase activity
ETK61_RS01925	COG0492	ferredoxin-NADP+ reductase activity
ETK61_RS01930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETK61_RS01930	COG1587	Uroporphyrinogen-III synthase
ETK61_RS01935	COG2146	nitrite reductase [NAD(P)H] activity
ETK61_RS01940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK61_RS01945	COG0243	molybdopterin cofactor binding
ETK61_RS01950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK61_RS01955	COG2223	nitrite transmembrane transporter activity
ETK61_RS01960	COG1469	GTP cyclohydrolase I activity
ETK61_RS01965	COG1376	ErfK ybiS ycfS ynhG family protein
ETK61_RS01975	COG0523	cobalamin synthesis protein
ETK61_RS01980	COG0765	amino acid transport
ETK61_RS01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS01995	COG1714	RDD family
ETK61_RS02005	COG2723	6-phospho-beta-galactosidase activity
ETK61_RS02015	COG3209	COG3209 Rhs family protein
ETK61_RS02020	COG3290	protein histidine kinase activity
ETK61_RS02020	COG0840	transmembrane signaling receptor activity
ETK61_RS02025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ETK61_RS02030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ETK61_RS02035	COG1733	regulation of RNA biosynthetic process
ETK61_RS02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS02045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS02050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS02055	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ETK61_RS02060	COG2814	Major facilitator Superfamily
ETK61_RS02070	COG0697	spore germination
ETK61_RS02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS02085	COG2364	Membrane
ETK61_RS02090	COG1126	abc transporter atp-binding protein
ETK61_RS02095	COG0765	amino acid transport
ETK61_RS02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS02105	COG0583	DNA-binding transcription factor activity
ETK61_RS02110	COG0163	prenyltransferase activity
ETK61_RS02115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ETK61_RS02130	COG0596	Alpha beta hydrolase
ETK61_RS02135	COG3104	oligopeptide transport
ETK61_RS02140	COG5434	Belongs to the glycosyl hydrolase 28 family
ETK61_RS02150	COG0697	spore germination
ETK61_RS02160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ETK61_RS02165	COG1136	(ABC) transporter
ETK61_RS02170	COG0577	efflux transmembrane transporter activity
ETK61_RS02175	COG0745	RESPONSE REGULATOR receiver
ETK61_RS02180	COG5002	protein histidine kinase activity
ETK61_RS02180	COG3850	Histidine kinase
ETK61_RS02185	COG0457	Tetratricopeptide repeat
ETK61_RS02205	COG0527	aspartate kinase activity
ETK61_RS02210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS02215	COG4605	iron ion homeostasis
ETK61_RS02220	COG4604	ABC transporter, ATP-binding protein
ETK61_RS02225	COG4607	ABC-type enterochelin transport system periplasmic component
ETK61_RS02230	COG2814	Major facilitator Superfamily
ETK61_RS02235	COG1309	transcriptional regulator
ETK61_RS02240	COG0778	Nitroreductase
ETK61_RS02245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ETK61_RS02250	COG0640	Transcriptional regulator
ETK61_RS02255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ETK61_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS02270	COG4975	Glucose uptake
ETK61_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS02280	COG4549	nuclear export factor GLE1
ETK61_RS02285	COG1276	copper resistance
ETK61_RS02285	COG2372	response to copper ion
ETK61_RS02290	COG1349	DNA-binding transcription factor activity
ETK61_RS02300	COG2213	PTS system mannitol-specific
ETK61_RS02305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS02310	COG0246	Mannitol dehydrogenase
ETK61_RS02315	COG0473	3-isopropylmalate dehydrogenase activity
ETK61_RS02320	COG0681	Belongs to the peptidase S26 family
ETK61_RS02325	COG0412	Dienelactone hydrolase
ETK61_RS02330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETK61_RS02340	COG0561	phosphatase activity
ETK61_RS02345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ETK61_RS02350	COG1914	H( )-stimulated, divalent metal cation uptake system
ETK61_RS02355	COG4336	lyase activity
ETK61_RS02360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ETK61_RS02365	COG1984	allophanate hydrolase subunit 2
ETK61_RS02370	COG1414	Transcriptional regulator
ETK61_RS02375	COG2755	lipolytic protein G-D-S-L family
ETK61_RS02385	COG2329	Antibiotic biosynthesis monooxygenase
ETK61_RS02390	COG0768	penicillin binding
ETK61_RS02395	COG4989	oxidoreductase activity
ETK61_RS02400	COG3711	transcriptional antiterminator
ETK61_RS02405	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS02410	COG2226	methyltransferase
ETK61_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS02430	COG3871	stress protein (general stress protein 26)
ETK61_RS02440	COG2814	Major facilitator Superfamily
ETK61_RS02445	COG1522	sequence-specific DNA binding
ETK61_RS02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ETK61_RS02450	COG0551	DNA topoisomerase type I activity
ETK61_RS02460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ETK61_RS02470	COG5298	Protein conserved in bacteria
ETK61_RS02490	COG1914	H( )-stimulated, divalent metal cation uptake system
ETK61_RS02495	COG2261	transglycosylase associated protein
ETK61_RS02500	COG4876	unkown
ETK61_RS02505	COG2217	Heavy metal translocating P-type atpase
ETK61_RS02510	COG3729	General stress protein
ETK61_RS02515	COG0662	Cupin 2, conserved barrel domain protein
ETK61_RS02520	COG2329	Antibiotic biosynthesis monooxygenase
ETK61_RS02530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ETK61_RS02535	COG3290	protein histidine kinase activity
ETK61_RS02540	COG4565	transcriptional regulatory protein
ETK61_RS02545	COG1301	dicarboxylic acid transport
ETK61_RS02550	COG0628	permease
ETK61_RS02555	COG1131	(ABC) transporter
ETK61_RS02560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK61_RS02570	COG1960	acyl-CoA dehydrogenase activity
ETK61_RS02585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ETK61_RS02590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS02595	COG1181	Belongs to the D-alanine--D-alanine ligase family
ETK61_RS02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ETK61_RS02610	COG0513	Belongs to the DEAD box helicase family
ETK61_RS02615	COG3402	PFAM membrane-flanked domain
ETK61_RS02620	COG3428	Bacterial PH domain
ETK61_RS02630	COG0705	Rhomboid family
ETK61_RS02635	COG0736	holo-[acyl-carrier-protein] synthase activity
ETK61_RS02640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ETK61_RS02645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ETK61_RS02650	COG0864	Transcriptional regulator
ETK61_RS02655	COG2337	Toxic component of a toxin-antitoxin (TA) module
ETK61_RS02660	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS02665	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS02670	COG2172	sigma factor antagonist activity
ETK61_RS02675	COG2208	phosphoserine phosphatase activity
ETK61_RS02680	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS02685	COG2172	sigma factor antagonist activity
ETK61_RS02690	COG1191	sigma factor activity
ETK61_RS02695	COG2208	phosphoserine phosphatase activity
ETK61_RS02700	COG2183	response to ionizing radiation
ETK61_RS02710	COG3091	SprT-like family
ETK61_RS02750	COG0582	viral genome integration into host DNA
ETK61_RS02755	COG2856	Zn peptidase
ETK61_RS02760	COG1396	sequence-specific DNA binding
ETK61_RS02790	COG1674	ftsk spoiiie
ETK61_RS02795	COG2946	Replication initiation factor
ETK61_RS02835	COG0433	COG0433 Predicted ATPase
ETK61_RS02845	COG5644	endopeptidase inhibitor activity
ETK61_RS02850	COG0791	NLP P60 protein
ETK61_RS02850	COG0741	lytic transglycosylase activity
ETK61_RS02865	COG0457	Tetratricopeptide repeat
ETK61_RS02885	COG0583	DNA-binding transcription factor activity
ETK61_RS02890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS02930	COG1476	TRANSCRIPTIONal
ETK61_RS02940	COG3239	Fatty acid desaturase
ETK61_RS02945	COG1278	Cold shock
ETK61_RS02960	COG0697	spore germination
ETK61_RS02965	COG2207	Transcriptional regulator
ETK61_RS02965	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS02970	COG0697	spore germination
ETK61_RS02975	COG3708	Transcriptional regulator
ETK61_RS02975	COG2207	Transcriptional regulator
ETK61_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS02985	COG0477	Major facilitator Superfamily
ETK61_RS02995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ETK61_RS03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS03015	COG1309	transcriptional regulator
ETK61_RS03020	COG0697	spore germination
ETK61_RS03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS03030	COG2030	dehydratase
ETK61_RS03035	COG3545	Serine hydrolase
ETK61_RS03040	COG1733	regulation of RNA biosynthetic process
ETK61_RS03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS03050	COG1733	regulation of RNA biosynthetic process
ETK61_RS03060	COG2814	Major facilitator Superfamily
ETK61_RS03065	COG1309	transcriptional regulator
ETK61_RS03075	COG0640	Transcriptional regulator
ETK61_RS03080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ETK61_RS03085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK61_RS03090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS03095	COG0697	spore germination
ETK61_RS03100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS03105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ETK61_RS03110	COG0640	Transcriptional regulator
ETK61_RS03115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ETK61_RS03130	COG4585	Histidine kinase
ETK61_RS03135	COG2197	response regulator
ETK61_RS03140	COG2409	Drug exporters of the RND superfamily
ETK61_RS03145	COG0596	Alpha beta hydrolase
ETK61_RS03150	COG1811	Na channel or pump
ETK61_RS03155	COG0789	Transcriptional regulator
ETK61_RS03155	COG4978	Transcriptional regulator
ETK61_RS03175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ETK61_RS03180	COG0778	Nitroreductase
ETK61_RS03185	COG0346	lactoylglutathione lyase activity
ETK61_RS03190	COG2259	Doxx family
ETK61_RS03195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS03210	COG2323	membrane
ETK61_RS03215	COG2323	membrane
ETK61_RS03220	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK61_RS03235	COG1309	transcriptional regulator
ETK61_RS03245	COG0456	acetyltransferase
ETK61_RS03255	COG0673	inositol 2-dehydrogenase activity
ETK61_RS03260	COG1609	Transcriptional regulator
ETK61_RS03265	COG2814	Major facilitator Superfamily
ETK61_RS03270	COG1082	Xylose isomerase domain protein TIM barrel
ETK61_RS03275	COG0488	(ABC) transporter
ETK61_RS03280	COG1113	amino acid transport
ETK61_RS03285	COG2318	DinB family
ETK61_RS03290	COG1846	Transcriptional regulator
ETK61_RS03295	COG2409	Drug exporters of the RND superfamily
ETK61_RS03295	COG1033	growth of symbiont in host cell
ETK61_RS03300	COG0778	Nitroreductase
ETK61_RS03305	COG1846	Transcriptional regulator
ETK61_RS03310	COG2814	Major facilitator Superfamily
ETK61_RS03315	COG0730	response to heat
ETK61_RS03320	COG1802	Transcriptional regulator
ETK61_RS03325	COG1388	LysM domain
ETK61_RS03325	COG3858	chitin binding
ETK61_RS03330	COG1819	glycosyl
ETK61_RS03340	COG1785	Belongs to the alkaline phosphatase family
ETK61_RS03345	COG5646	InterPro IPR014922
ETK61_RS03355	COG0454	-acetyltransferase
ETK61_RS03360	COG1078	dGTPase activity
ETK61_RS03365	COG1388	LysM domain
ETK61_RS03370	COG2814	Major facilitator Superfamily
ETK61_RS03375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK61_RS03380	COG1447	Phosphotransferase system cellobiose-specific component IIA
ETK61_RS03385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK61_RS03390	COG2723	6-phospho-beta-galactosidase activity
ETK61_RS03395	COG2188	Transcriptional regulator
ETK61_RS03400	COG1940	carbohydrate kinase activity
ETK61_RS03405	COG1482	cell wall glycoprotein biosynthetic process
ETK61_RS03410	COG4124	Belongs to the glycosyl hydrolase 26 family
ETK61_RS03455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ETK61_RS03460	COG0802	atpase or kinase
ETK61_RS03465	COG1214	PFAM Peptidase M22, glycoprotease
ETK61_RS03470	COG0456	acetyltransferase
ETK61_RS03475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ETK61_RS03480	COG0488	(ABC) transporter
ETK61_RS03485	COG0315	cyclic pyranopterin monophosphate synthase activity
ETK61_RS03490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ETK61_RS03495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETK61_RS03500	COG0805	protein transport
ETK61_RS03515	COG1266	CAAX protease self-immunity
ETK61_RS03525	COG0459	protein refolding
ETK61_RS03550	COG0457	Tetratricopeptide repeat
ETK61_RS03555	COG1063	alcohol dehydrogenase
ETK61_RS03560	COG2211	Major facilitator Superfamily
ETK61_RS03565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK61_RS03570	COG1842	Phage shock protein A
ETK61_RS03575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ETK61_RS03580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ETK61_RS03585	COG4260	virion core protein, lumpy skin disease virus
ETK61_RS03595	COG2814	Major facilitator Superfamily
ETK61_RS03600	COG1063	alcohol dehydrogenase
ETK61_RS03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ETK61_RS03610	COG0823	Involved in the tonB-independent uptake of proteins
ETK61_RS03630	COG2267	carboxylic ester hydrolase activity
ETK61_RS03640	COG2132	Multicopper oxidase
ETK61_RS03645	COG1113	amino acid transport
ETK61_RS03655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ETK61_RS03660	COG0714	Associated with various cellular activities
ETK61_RS03665	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ETK61_RS03670	COG1305	Transglutaminase-like
ETK61_RS03675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ETK61_RS03675	COG0519	Catalyzes the synthesis of GMP from XMP
ETK61_RS03685	COG2252	PERMEase
ETK61_RS03690	COG3064	Membrane
ETK61_RS03700	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ETK61_RS03710	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ETK61_RS03715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ETK61_RS03720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ETK61_RS03725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ETK61_RS03730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETK61_RS03735	COG0047	phosphoribosylformylglycinamidine synthase activity
ETK61_RS03740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ETK61_RS03745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ETK61_RS03750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ETK61_RS03755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ETK61_RS03760	COG0138	bifunctional purine biosynthesis protein purh
ETK61_RS03765	COG0151	Belongs to the GarS family
ETK61_RS03770	COG1522	sequence-specific DNA binding
ETK61_RS03775	COG0531	amino acid
ETK61_RS03785	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ETK61_RS03790	COG1470	cell adhesion involved in biofilm formation
ETK61_RS03795	COG4496	protein, YerC YecD
ETK61_RS03800	COG0069	glutamate synthase activity
ETK61_RS03805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ETK61_RS03810	COG0210	DNA helicase
ETK61_RS03815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ETK61_RS03820	COG4851	CamS sex pheromone cAM373 precursor
ETK61_RS03830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK61_RS03835	COG1285	pathogenesis
ETK61_RS03840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK61_RS03845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETK61_RS03850	COG0154	amidase activity
ETK61_RS03855	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ETK61_RS03860	COG1309	transcriptional regulator
ETK61_RS03865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ETK61_RS03870	COG1597	lipid kinase activity
ETK61_RS03875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ETK61_RS03885	COG0457	Tetratricopeptide repeat
ETK61_RS03905	COG5444	nuclease activity
ETK61_RS03915	COG3586	endonuclease activity
ETK61_RS03925	COG0457	Tetratricopeptide repeat
ETK61_RS03935	COG0217	transcriptional regulatory protein
ETK61_RS03945	COG1309	transcriptional regulator
ETK61_RS03960	COG3546	catalase activity
ETK61_RS03965	COG0454	-acetyltransferase
ETK61_RS03975	COG5578	integral membrane protein
ETK61_RS03980	COG2972	Histidine kinase
ETK61_RS03985	COG4753	response regulator
ETK61_RS03985	COG2207	Transcriptional regulator
ETK61_RS03990	COG1653	transport
ETK61_RS03995	COG1175	transmembrane transport
ETK61_RS04005	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ETK61_RS04015	COG2755	lipolytic protein G-D-S-L family
ETK61_RS04025	COG5578	integral membrane protein
ETK61_RS04035	COG3401	FG-GAP repeat protein
ETK61_RS04040	COG2755	lipolytic protein G-D-S-L family
ETK61_RS04055	COG1653	transport
ETK61_RS04060	COG4209	transmembrane transport
ETK61_RS04065	COG0395	ABC-type sugar transport system, permease component
ETK61_RS04070	COG1486	melibiose metabolic process
ETK61_RS04075	COG2323	membrane
ETK61_RS04080	COG2329	Antibiotic biosynthesis monooxygenase
ETK61_RS04085	COG0346	lactoylglutathione lyase activity
ETK61_RS04100	COG5583	Uncharacterized small protein (DUF2292)
ETK61_RS04105	COG0670	Belongs to the BI1 family
ETK61_RS04120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ETK61_RS04130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ETK61_RS04130	COG2124	cytochrome p450
ETK61_RS04135	COG1368	sulfuric ester hydrolase activity
ETK61_RS04140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ETK61_RS04145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK61_RS04150	COG1442	glycosyl transferase family 8
ETK61_RS04155	COG1216	Glycosyl transferase, family 2
ETK61_RS04160	COG1442	glycosyl transferase family 8
ETK61_RS04165	COG2223	nitrite transmembrane transporter activity
ETK61_RS04175	COG0531	amino acid
ETK61_RS04180	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS04185	COG0840	transmembrane signaling receptor activity
ETK61_RS04190	COG0488	(ABC) transporter
ETK61_RS04200	COG0789	Transcriptional regulator
ETK61_RS04205	COG2814	Major facilitator Superfamily
ETK61_RS04220	COG0488	(ABC) transporter
ETK61_RS04225	COG0513	Belongs to the DEAD box helicase family
ETK61_RS04230	COG0456	acetyltransferase
ETK61_RS04235	COG2130	NADP-dependent
ETK61_RS04240	COG1120	ATPase activity
ETK61_RS04245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS04255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ETK61_RS04270	COG3866	Pectate lyase
ETK61_RS04275	COG0471	metal ion transport
ETK61_RS04280	COG3290	protein histidine kinase activity
ETK61_RS04285	COG4565	transcriptional regulatory protein
ETK61_RS04290	COG3181	Tripartite tricarboxylate transporter family receptor
ETK61_RS04295	COG2851	Citrate transporter
ETK61_RS04300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS04305	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ETK61_RS04310	COG1254	Belongs to the acylphosphatase family
ETK61_RS04335	COG0024	Methionine aminopeptidase
ETK61_RS04340	COG1263	PTS System
ETK61_RS04340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS04345	COG1368	sulfuric ester hydrolase activity
ETK61_RS04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS04370	COG1263	PTS System
ETK61_RS04375	COG0366	Alpha amylase catalytic
ETK61_RS04380	COG2188	Transcriptional regulator
ETK61_RS04385	COG0778	Nitroreductase
ETK61_RS04390	COG0737	Belongs to the 5'-nucleotidase family
ETK61_RS04395	COG0693	protein deglycase activity
ETK61_RS04400	COG2814	Major facilitator Superfamily
ETK61_RS04405	COG4840	Belongs to the UPF0435 family
ETK61_RS04410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK61_RS04415	COG4980	gas vesicle protein
ETK61_RS04420	COG1295	ribonuclease BN
ETK61_RS04425	COG0477	Major facilitator Superfamily
ETK61_RS04430	COG0387	Pfam Sodium calcium exchanger
ETK61_RS04440	COG0668	transmembrane transport
ETK61_RS04445	COG0535	radical SAM domain protein
ETK61_RS04455	COG0726	polysaccharide deacetylase
ETK61_RS04460	COG2084	Dehydrogenase
ETK61_RS04465	COG0598	Magnesium transport protein CorA
ETK61_RS04470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ETK61_RS04475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ETK61_RS04485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ETK61_RS04490	COG4637	Psort location Cytoplasmic, score
ETK61_RS04500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK61_RS04505	COG0022	dehydrogenase e1 component
ETK61_RS04510	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK61_RS04515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK61_RS04520	COG3284	Transcriptional regulator
ETK61_RS04530	COG1742	UPF0060 membrane protein
ETK61_RS04550	COG4842	Belongs to the WXG100 family
ETK61_RS04555	COG1486	melibiose metabolic process
ETK61_RS04560	COG1737	Transcriptional regulator
ETK61_RS04565	COG1263	PTS System
ETK61_RS04565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS04570	COG1132	(ABC) transporter
ETK61_RS04575	COG1132	(ABC) transporter
ETK61_RS04580	COG2259	Doxx family
ETK61_RS04585	COG2514	catechol 2,3-dioxygenase activity
ETK61_RS04590	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS04590	COG4977	sequence-specific DNA binding
ETK61_RS04595	COG2814	Major facilitator Superfamily
ETK61_RS04600	COG1082	Xylose isomerase domain protein TIM barrel
ETK61_RS04605	COG0673	inositol 2-dehydrogenase activity
ETK61_RS04610	COG4585	Histidine kinase
ETK61_RS04615	COG2197	response regulator
ETK61_RS04625	COG1131	(ABC) transporter
ETK61_RS04630	COG0842	Transport permease protein
ETK61_RS04630	COG1511	domain protein
ETK61_RS04635	COG0842	Transport permease protein
ETK61_RS04640	COG1695	Transcriptional regulator
ETK61_RS04645	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ETK61_RS04650	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ETK61_RS04655	COG1309	transcriptional regulator
ETK61_RS04660	COG2814	Major facilitator Superfamily
ETK61_RS04665	COG2318	DinB family
ETK61_RS04670	COG2814	Major facilitator Superfamily
ETK61_RS04675	COG1846	Transcriptional regulator
ETK61_RS04680	COG0392	lysyltransferase activity
ETK61_RS04680	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ETK61_RS04685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS04690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS04695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS04705	COG0778	Nitroreductase
ETK61_RS04720	COG1090	epimerase
ETK61_RS04725	COG2137	regulation of response to DNA damage stimulus
ETK61_RS04735	COG2814	Major facilitator Superfamily
ETK61_RS04755	COG3103	Sh3 type 3 domain protein
ETK61_RS04760	COG5658	integral membrane protein
ETK61_RS04765	COG0596	Alpha beta hydrolase
ETK61_RS04770	COG0463	Glycosyl transferase, family 2
ETK61_RS04775	COG4485	Bacterial membrane protein, YfhO
ETK61_RS04780	COG1988	membrane-bound metal-dependent
ETK61_RS04785	COG1194	a g-specific adenine glycosylase
ETK61_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS04810	COG3557	Belongs to the UPF0374 family
ETK61_RS04815	COG1132	(ABC) transporter
ETK61_RS04820	COG4129	membrane
ETK61_RS04825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETK61_RS04830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ETK61_RS04835	COG0735	belongs to the Fur family
ETK61_RS04950	COG4326	sporulation control protein
ETK61_RS04960	COG5577	PFAM Coat F domain
ETK61_RS04965	COG3340	Belongs to the peptidase S51 family
ETK61_RS04970	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ETK61_RS04975	COG0277	FAD linked oxidase domain protein
ETK61_RS04985	COG0753	catalase activity
ETK61_RS04990	COG1116	anion transmembrane transporter activity
ETK61_RS04995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ETK61_RS05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ETK61_RS05005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS05015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ETK61_RS05025	COG1476	TRANSCRIPTIONal
ETK61_RS05035	COG3382	B3 4 domain protein
ETK61_RS05040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ETK61_RS05050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ETK61_RS05055	COG0789	Transcriptional regulator
ETK61_RS05060	COG1664	Polymer-forming cytoskeletal
ETK61_RS05065	COG2766	serine protein kinase
ETK61_RS05070	COG2718	Belongs to the UPF0229 family
ETK61_RS05075	COG1846	Transcriptional regulator
ETK61_RS05080	COG1566	PFAM secretion protein HlyD family protein
ETK61_RS05085	COG2814	Major facilitator Superfamily
ETK61_RS05090	COG0655	NAD(P)H dehydrogenase (quinone) activity
ETK61_RS05110	COG1725	Transcriptional regulator
ETK61_RS05115	COG1131	(ABC) transporter
ETK61_RS05120	COG1131	(ABC) transporter
ETK61_RS05125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK61_RS05130	COG1278	Cold shock
ETK61_RS05140	COG1464	Belongs to the NlpA lipoprotein family
ETK61_RS05150	COG1823	symporter activity
ETK61_RS05155	COG0582	viral genome integration into host DNA
ETK61_RS05160	COG2856	Zn peptidase
ETK61_RS05165	COG1396	sequence-specific DNA binding
ETK61_RS05200	COG1674	ftsk spoiiie
ETK61_RS05205	COG2946	Replication initiation factor
ETK61_RS05240	COG0433	COG0433 Predicted ATPase
ETK61_RS05250	COG5644	endopeptidase inhibitor activity
ETK61_RS05255	COG0791	NLP P60 protein
ETK61_RS05255	COG0741	lytic transglycosylase activity
ETK61_RS05275	COG0457	Tetratricopeptide repeat
ETK61_RS05300	COG0737	Belongs to the 5'-nucleotidase family
ETK61_RS05300	COG1525	nuclease
ETK61_RS05300	COG4085	toxin activity
ETK61_RS05305	COG3764	Sortase (surface protein transpeptidase)
ETK61_RS05310	COG0564	pseudouridine synthase activity
ETK61_RS05320	COG0517	IMP dehydrogenase activity
ETK61_RS05325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ETK61_RS05330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ETK61_RS05330	COG3153	acetyltransferase
ETK61_RS05335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK61_RS05340	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ETK61_RS05345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ETK61_RS05350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ETK61_RS05355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ETK61_RS05360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ETK61_RS05365	COG2203	Gaf domain
ETK61_RS05365	COG4585	Histidine kinase
ETK61_RS05370	COG2197	response regulator
ETK61_RS05375	COG0431	NADPH-dependent FMN reductase
ETK61_RS05390	COG0791	NLP P60 protein
ETK61_RS05390	COG1388	LysM domain
ETK61_RS05395	COG1959	2 iron, 2 sulfur cluster binding
ETK61_RS05405	COG2719	SpoVR family
ETK61_RS05410	COG1785	Belongs to the alkaline phosphatase family
ETK61_RS05415	COG1388	LysM domain
ETK61_RS05415	COG0791	NLP P60 protein
ETK61_RS05420	COG0583	DNA-binding transcription factor activity
ETK61_RS05425	COG0372	Belongs to the citrate synthase family
ETK61_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS05435	COG0531	amino acid
ETK61_RS05440	COG0733	neurotransmitter:sodium symporter activity
ETK61_RS05445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS05450	COG0456	acetyltransferase
ETK61_RS05465	COG1595	DNA-templated transcription, initiation
ETK61_RS05470	COG0667	Aldo Keto reductase
ETK61_RS05475	COG0204	Acyl-transferase
ETK61_RS05480	COG1253	flavin adenine dinucleotide binding
ETK61_RS05485	COG0789	Transcriptional regulator
ETK61_RS05490	COG0436	Aminotransferase
ETK61_RS05495	COG1253	flavin adenine dinucleotide binding
ETK61_RS05500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ETK61_RS05505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ETK61_RS05510	COG0584	glycerophosphoryl diester phosphodiesterase
ETK61_RS05520	COG0668	transmembrane transport
ETK61_RS05525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ETK61_RS05530	COG0726	polysaccharide deacetylase
ETK61_RS05535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK61_RS05540	COG1757	Na H antiporter
ETK61_RS05545	COG0589	response to stress
ETK61_RS05555	COG1132	(ABC) transporter
ETK61_RS05560	COG1132	(ABC) transporter
ETK61_RS05565	COG0702	epimerase
ETK61_RS05585	COG0189	ligase activity
ETK61_RS05590	COG0189	ligase activity
ETK61_RS05595	COG4399	Belongs to the UPF0754 family
ETK61_RS05600	COG3679	Belongs to the UPF0342 family
ETK61_RS05610	COG0561	phosphatase activity
ETK61_RS05615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETK61_RS05620	COG0475	glutathione-regulated potassium exporter activity
ETK61_RS05625	COG0490	domain, Protein
ETK61_RS05635	COG1024	Enoyl-CoA hydratase
ETK61_RS05645	COG4152	abc transporter atp-binding protein
ETK61_RS05650	COG1668	transmembrane transport
ETK61_RS05655	COG0420	3'-5' exonuclease activity
ETK61_RS05660	COG4717	serine-type aminopeptidase activity
ETK61_RS05665	COG3481	metal-dependent phosphohydrolase, HD sub domain
ETK61_RS05675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ETK61_RS05705	COG1846	Transcriptional regulator
ETK61_RS05710	COG4980	gas vesicle protein
ETK61_RS05725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ETK61_RS05730	COG0537	adenosine 5'-monophosphoramidase activity
ETK61_RS05735	COG1131	(ABC) transporter
ETK61_RS05740	COG4473	ABC transporter
ETK61_RS05750	COG1473	amidohydrolase
ETK61_RS05755	COG3069	C4-dicarboxylate transmembrane transporter activity
ETK61_RS05765	COG2329	Antibiotic biosynthesis monooxygenase
ETK61_RS05770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK61_RS05775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ETK61_RS05780	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ETK61_RS05785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ETK61_RS05790	COG1309	transcriptional regulator
ETK61_RS05795	COG1511	domain protein
ETK61_RS05800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK61_RS05805	COG4377	Putative membrane peptidase family (DUF2324)
ETK61_RS05815	COG1363	Peptidase, m42
ETK61_RS05820	COG4405	Protein conserved in bacteria
ETK61_RS05830	COG1301	dicarboxylic acid transport
ETK61_RS05840	COG1234	tRNA 3'-trailer cleavage
ETK61_RS05845	COG0095	Lipoate-protein ligase
ETK61_RS05850	COG0702	epimerase
ETK61_RS05855	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS05865	COG0501	Belongs to the peptidase M48B family
ETK61_RS05875	COG0456	acetyltransferase
ETK61_RS05880	COG0604	alcohol dehydrogenase
ETK61_RS05885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ETK61_RS05895	COG0406	alpha-ribazole phosphatase activity
ETK61_RS05900	COG0183	Belongs to the thiolase family
ETK61_RS05905	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS05910	COG1268	BioY protein
ETK61_RS05915	COG0840	transmembrane signaling receptor activity
ETK61_RS05920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ETK61_RS05920	COG0723	plastoquinol--plastocyanin reductase activity
ETK61_RS05925	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS05935	COG4903	ComK protein
ETK61_RS05955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK61_RS05970	COG0398	Pfam SNARE associated Golgi protein
ETK61_RS05975	COG0681	Belongs to the peptidase S26 family
ETK61_RS05985	COG1846	Transcriptional regulator
ETK61_RS05990	COG0738	Major facilitator superfamily
ETK61_RS05995	COG0673	inositol 2-dehydrogenase activity
ETK61_RS06000	COG0561	phosphatase activity
ETK61_RS06005	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK61_RS06010	COG1609	Transcriptional regulator
ETK61_RS06015	COG3180	Ammonia monooxygenase
ETK61_RS06020	COG0477	Major facilitator Superfamily
ETK61_RS06020	COG2814	Major facilitator Superfamily
ETK61_RS06025	COG4533	DNA binding
ETK61_RS06035	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ETK61_RS06040	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ETK61_RS06045	COG1074	ATP-dependent DNA helicase activity
ETK61_RS06050	COG0420	3'-5' exonuclease activity
ETK61_RS06055	COG0419	ATPase involved in DNA repair
ETK61_RS06060	COG1403	HNH endonuclease
ETK61_RS06100	COG5337	Spore coat protein CotH
ETK61_RS06105	COG0179	Fumarylacetoacetate (FAA) hydrolase
ETK61_RS06115	COG1404	Belongs to the peptidase S8 family
ETK61_RS06125	COG0367	asparagine synthase
ETK61_RS06130	COG1562	ergosterol biosynthetic process
ETK61_RS06135	COG0534	Mate efflux family protein
ETK61_RS06140	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS06140	COG2207	Transcriptional regulator
ETK61_RS06145	COG1609	Transcriptional regulator
ETK61_RS06150	COG0673	inositol 2-dehydrogenase activity
ETK61_RS06155	COG2318	DinB family
ETK61_RS06160	COG1279	arginine transmembrane transporter activity
ETK61_RS06165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS06170	COG1357	PFAM Pentapeptide repeats (8 copies)
ETK61_RS06175	COG2267	carboxylic ester hydrolase activity
ETK61_RS06180	COG0529	Catalyzes the synthesis of activated sulfate
ETK61_RS06195	COG2045	Belongs to the ComB family
ETK61_RS06200	COG1809	phosphosulfolactate synthase activity
ETK61_RS06205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS06250	COG3546	catalase activity
ETK61_RS06275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK61_RS06290	COG2323	membrane
ETK61_RS06300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK61_RS06310	COG2814	Major facilitator Superfamily
ETK61_RS06315	COG0454	-acetyltransferase
ETK61_RS06320	COG2153	protein acetylation
ETK61_RS06325	COG0646	methionine synthase
ETK61_RS06325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ETK61_RS06330	COG1666	GTP binding
ETK61_RS06335	COG2996	Protein conserved in bacteria
ETK61_RS06350	COG1307	EDD domain protein, DegV family
ETK61_RS06355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS06370	COG0561	phosphatase activity
ETK61_RS06375	COG1073	alpha beta
ETK61_RS06380	COG2151	metal-sulfur cluster biosynthetic enzyme
ETK61_RS06390	COG0277	FAD linked oxidase domain protein
ETK61_RS06395	COG2271	Major facilitator Superfamily
ETK61_RS06400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ETK61_RS06405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ETK61_RS06415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ETK61_RS06420	COG0505	Belongs to the CarA family
ETK61_RS06425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ETK61_RS06430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ETK61_RS06445	COG2267	carboxylic ester hydrolase activity
ETK61_RS06455	COG1744	ABC transporter substrate-binding protein PnrA-like
ETK61_RS06470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK61_RS06475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ETK61_RS06480	COG5504	Zn-dependent protease
ETK61_RS06485	COG0444	Belongs to the ABC transporter superfamily
ETK61_RS06490	COG4608	Belongs to the ABC transporter superfamily
ETK61_RS06500	COG0601	transmembrane transport
ETK61_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK61_RS06515	COG0180	Tryptophanyl-tRNA synthetase
ETK61_RS06520	COG4166	transmembrane transport
ETK61_RS06525	COG0601	transmembrane transport
ETK61_RS06530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK61_RS06535	COG0444	Belongs to the ABC transporter superfamily
ETK61_RS06540	COG4608	Belongs to the ABC transporter superfamily
ETK61_RS06545	COG2814	Major facilitator Superfamily
ETK61_RS06550	COG0456	acetyltransferase
ETK61_RS06555	COG1393	Belongs to the ArsC family
ETK61_RS06560	COG0861	Integral membrane protein TerC family
ETK61_RS06570	COG4862	establishment of competence for transformation
ETK61_RS06580	COG4469	Competence protein
ETK61_RS06585	COG1164	Oligoendopeptidase f
ETK61_RS06600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ETK61_RS06605	COG2346	COG2346, Truncated hemoglobins
ETK61_RS06610	COG0741	lytic transglycosylase activity
ETK61_RS06615	COG4116	CYTH
ETK61_RS06625	COG2357	RelA SpoT domain protein
ETK61_RS06630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ETK61_RS06635	COG0564	pseudouridine synthase activity
ETK61_RS06640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ETK61_RS06645	COG0475	glutathione-regulated potassium exporter activity
ETK61_RS06645	COG0569	domain protein
ETK61_RS06650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ETK61_RS06655	COG0352	thiamine-phosphate diphosphorylase activity
ETK61_RS06660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ETK61_RS06665	COG2104	thiamine diphosphate biosynthetic process
ETK61_RS06670	COG2022	thiamine diphosphate biosynthetic process
ETK61_RS06675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ETK61_RS06680	COG0351	phosphomethylpyrimidine kinase
ETK61_RS06685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ETK61_RS06740	COG0210	DNA helicase
ETK61_RS06750	COG2153	protein acetylation
ETK61_RS06755	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ETK61_RS06760	COG2382	esterase
ETK61_RS06765	COG0626	cystathionine gamma-synthase activity
ETK61_RS06770	COG0626	cystathionine gamma-synthase activity
ETK61_RS06775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS06780	COG5505	Protein of unknown function (DUF819)
ETK61_RS06805	COG5444	nuclease activity
ETK61_RS06860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ETK61_RS06865	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS06875	COG3711	transcriptional antiterminator
ETK61_RS06875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS06880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK61_RS06880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK61_RS06880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS06885	COG1482	cell wall glycoprotein biosynthetic process
ETK61_RS06895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS06905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ETK61_RS06925	COG0109	protoheme IX farnesyltransferase activity
ETK61_RS06935	COG0726	polysaccharide deacetylase
ETK61_RS06955	COG5504	Zn-dependent protease
ETK61_RS06960	COG2205	protein histidine kinase activity
ETK61_RS06975	COG2427	Protein of unknown function (DUF1641)
ETK61_RS06995	COG2124	cytochrome p450
ETK61_RS07000	COG1819	glycosyl
ETK61_RS07010	COG1587	Uroporphyrinogen-III synthase
ETK61_RS07015	COG0390	transport system, permease component
ETK61_RS07020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETK61_RS07025	COG0697	spore germination
ETK61_RS07030	COG4297	protein containing double-stranded beta helix domain
ETK61_RS07040	COG1252	NADH dehydrogenase
ETK61_RS07045	COG1904	glucuronate isomerase
ETK61_RS07050	COG2211	Major facilitator Superfamily
ETK61_RS07055	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ETK61_RS07060	COG1063	alcohol dehydrogenase
ETK61_RS07065	COG1312	Catalyzes the dehydration of D-mannonate
ETK61_RS07070	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS07075	COG2271	Major facilitator Superfamily
ETK61_RS07080	COG1609	Transcriptional regulator
ETK61_RS07085	COG0246	Mannitol dehydrogenase
ETK61_RS07090	COG2721	sulfolactate sulfo-lyase activity
ETK61_RS07095	COG0730	response to heat
ETK61_RS07100	COG2318	DinB family
ETK61_RS07105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ETK61_RS07110	COG0457	Tetratricopeptide repeat
ETK61_RS07120	COG2350	Protein conserved in bacteria
ETK61_RS07125	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS07125	COG1388	LysM domain
ETK61_RS07125	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS07135	COG4195	phage-related replication protein
ETK61_RS07140	COG3546	catalase activity
ETK61_RS07145	COG2856	Zn peptidase
ETK61_RS07150	COG1396	sequence-specific DNA binding
ETK61_RS07160	COG1522	sequence-specific DNA binding
ETK61_RS07165	COG1484	DNA-dependent DNA replication
ETK61_RS07185	COG1595	DNA-templated transcription, initiation
ETK61_RS07190	COG5484	DNA packaging
ETK61_RS07190	COG3728	DNA packaging
ETK61_RS07195	COG1783	phage Terminase large subunit
ETK61_RS07200	COG5518	Phage portal protein
ETK61_RS07205	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ETK61_RS07210	COG4653	Phage capsid family
ETK61_RS07260	COG5412	phage tail tape measure protein
ETK61_RS07260	COG3953	SLT domain
ETK61_RS07260	COG3953	SLT domain
ETK61_RS07260	COG5412	phage tail tape measure protein
ETK61_RS07265	COG1652	LysM domain
ETK61_RS07270	COG4193	domain, Protein
ETK61_RS07280	COG3628	GPW Gp25 family protein
ETK61_RS07285	COG3299	homolog of phage Mu protein gp47
ETK61_RS07290	COG3778	Protein conserved in bacteria
ETK61_RS07330	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS07330	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS07350	COG0306	phosphate transporter
ETK61_RS07355	COG1392	Phosphate transport regulator
ETK61_RS07360	COG0531	amino acid
ETK61_RS07365	COG0346	lactoylglutathione lyase activity
ETK61_RS07370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ETK61_RS07375	COG0463	Glycosyl transferase, family 2
ETK61_RS07380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK61_RS07385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK61_RS07390	COG2362	D-Aminopeptidase
ETK61_RS07395	COG0601	transmembrane transport
ETK61_RS07400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ETK61_RS07405	COG0444	Belongs to the ABC transporter superfamily
ETK61_RS07410	COG4166	transmembrane transport
ETK61_RS07415	COG1619	proteins homologs of microcin C7 resistance protein MccF
ETK61_RS07420	COG4948	Mandelate Racemase Muconate Lactonizing
ETK61_RS07425	COG0791	NLP P60 protein
ETK61_RS07430	COG4608	Belongs to the ABC transporter superfamily
ETK61_RS07435	COG2706	6-phosphogluconolactonase activity
ETK61_RS07440	COG1834	amidinotransferase
ETK61_RS07445	COG1607	acyl-coa hydrolase
ETK61_RS07450	COG1017	nitric oxide dioxygenase activity
ETK61_RS07450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ETK61_RS07460	COG2323	membrane
ETK61_RS07465	COG2318	DinB family
ETK61_RS07470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS07475	COG2076	Multidrug Resistance protein
ETK61_RS07480	COG2076	Multidrug Resistance protein
ETK61_RS07485	COG0788	formyltetrahydrofolate deformylase activity
ETK61_RS07490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ETK61_RS07495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ETK61_RS07500	COG1764	response to oxidative stress
ETK61_RS07505	COG1846	Transcriptional regulator
ETK61_RS07510	COG1764	response to oxidative stress
ETK61_RS07520	COG0590	tRNA wobble adenosine to inosine editing
ETK61_RS07525	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETK61_RS07530	COG1404	Belongs to the peptidase S8 family
ETK61_RS07535	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS07540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ETK61_RS07545	COG1122	ATPase activity
ETK61_RS07550	COG4721	ABC-type cobalt transport system, permease component
ETK61_RS07560	COG0745	RESPONSE REGULATOR receiver
ETK61_RS07575	COG3212	peptidase
ETK61_RS07590	COG2239	Acts as a magnesium transporter
ETK61_RS07595	COG0789	Transcriptional regulator
ETK61_RS07610	COG1846	Transcriptional regulator
ETK61_RS07615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK61_RS07620	COG0726	polysaccharide deacetylase
ETK61_RS07625	COG1408	metallophosphoesterase
ETK61_RS07635	COG0463	Glycosyl transferase, family 2
ETK61_RS07640	COG3285	dna ligase
ETK61_RS07640	COG1793	dna ligase
ETK61_RS07645	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ETK61_RS07650	COG5001	Diguanylate cyclase
ETK61_RS07650	COG3300	MHYT domain
ETK61_RS07655	COG0586	Pfam SNARE associated Golgi protein
ETK61_RS07660	COG0861	Integral membrane protein TerC family
ETK61_RS07665	COG1191	sigma factor activity
ETK61_RS07685	COG0501	Belongs to the peptidase M48B family
ETK61_RS07690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETK61_RS07705	COG3594	Acyltransferase
ETK61_RS07710	COG5002	protein histidine kinase activity
ETK61_RS07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ETK61_RS07725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ETK61_RS07730	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ETK61_RS07735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ETK61_RS07740	COG0436	Aminotransferase
ETK61_RS07745	COG1850	ribulose-bisphosphate carboxylase activity
ETK61_RS07750	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ETK61_RS07755	COG0235	Class ii aldolase
ETK61_RS07760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ETK61_RS07765	COG3339	Conserved Protein
ETK61_RS07780	COG3852	Histidine kinase
ETK61_RS07785	COG1846	Transcriptional regulator
ETK61_RS07790	COG1360	Flagellar Motor Protein
ETK61_RS07795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ETK61_RS07800	COG0542	response to heat
ETK61_RS07805	COG3949	Membrane
ETK61_RS07810	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ETK61_RS07815	COG0720	synthase
ETK61_RS07820	COG0602	queuosine metabolic process
ETK61_RS07825	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ETK61_RS07830	COG1733	regulation of RNA biosynthetic process
ETK61_RS07835	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS07910	COG4873	Protein conserved in bacteria
ETK61_RS07920	COG3773	Cell wall hydrolase
ETK61_RS07925	COG2244	polysaccharide biosynthetic process
ETK61_RS07930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS07935	COG2217	Heavy metal translocating P-type atpase
ETK61_RS07945	COG0006	proline dipeptidase activity
ETK61_RS07950	COG1609	Transcriptional regulator
ETK61_RS07955	COG3711	transcriptional antiterminator
ETK61_RS07960	COG2190	(PTS) system
ETK61_RS07960	COG1263	PTS System
ETK61_RS07960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS07965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS07970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ETK61_RS07980	COG1533	DNA photolyase activity
ETK61_RS07985	COG0456	acetyltransferase
ETK61_RS07990	COG0840	transmembrane signaling receptor activity
ETK61_RS07995	COG2084	Dehydrogenase
ETK61_RS08000	COG2340	Cysteine-rich secretory protein family
ETK61_RS08005	COG0768	penicillin binding
ETK61_RS08010	COG4191	Histidine kinase
ETK61_RS08015	COG0436	Aminotransferase
ETK61_RS08025	COG0784	Response regulator, receiver
ETK61_RS08025	COG0835	chemotaxis
ETK61_RS08035	COG2814	Major facilitator Superfamily
ETK61_RS08040	COG1376	ErfK ybiS ycfS ynhG family protein
ETK61_RS08045	COG1408	metallophosphoesterase
ETK61_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS08055	COG2200	EAL domain
ETK61_RS08060	COG4703	Protein of unknown function (DUF1797)
ETK61_RS08065	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ETK61_RS08075	COG0517	IMP dehydrogenase activity
ETK61_RS08080	COG0583	DNA-binding transcription factor activity
ETK61_RS08085	COG0716	FMN binding
ETK61_RS08095	COG0716	FMN binding
ETK61_RS08100	COG2171	N-acyltransferase activity
ETK61_RS08105	COG1473	amidohydrolase
ETK61_RS08115	COG0668	transmembrane transport
ETK61_RS08120	COG0450	alkyl hydroperoxide reductase
ETK61_RS08125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS08140	COG0746	molybdenum cofactor guanylyltransferase activity
ETK61_RS08145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ETK61_RS08150	COG0303	'Molybdopterin
ETK61_RS08155	COG1763	Mo-molybdopterin cofactor biosynthetic process
ETK61_RS08160	COG0314	molybdopterin synthase activity
ETK61_RS08165	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ETK61_RS08170	COG1132	(ABC) transporter
ETK61_RS08175	COG1132	(ABC) transporter
ETK61_RS08185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ETK61_RS08190	COG1136	(ABC) transporter
ETK61_RS08195	COG0577	efflux transmembrane transporter activity
ETK61_RS08200	COG1349	DNA-binding transcription factor activity
ETK61_RS08205	COG1105	Belongs to the carbohydrate kinase PfkB family
ETK61_RS08210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK61_RS08210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ETK61_RS08210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS08215	COG0681	Belongs to the peptidase S26 family
ETK61_RS08225	COG0488	(ABC) transporter
ETK61_RS08230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ETK61_RS08235	COG2309	aminopeptidase activity
ETK61_RS08245	COG1077	Cell shape determining protein MreB Mrl
ETK61_RS08250	COG2002	toxin-antitoxin pair type II binding
ETK61_RS08255	COG3852	Histidine kinase
ETK61_RS08260	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ETK61_RS08260	COG2105	PFAM AIG2 family protein
ETK61_RS08265	COG0569	domain protein
ETK61_RS08270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ETK61_RS08275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ETK61_RS08280	COG5503	Protein of unknown function (DUF1447)
ETK61_RS08285	COG0561	phosphatase activity
ETK61_RS08290	COG0242	peptide deformylase activity
ETK61_RS08300	COG0497	DNA recombination
ETK61_RS08305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK61_RS08310	COG0022	dehydrogenase e1 component
ETK61_RS08315	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK61_RS08320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK61_RS08325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS08335	COG1982	Orn Lys Arg decarboxylase major
ETK61_RS08340	COG4476	Belongs to the UPF0223 family
ETK61_RS08345	COG4493	Belongs to the UPF0637 family
ETK61_RS08355	COG0483	inositol monophosphate 1-phosphatase activity
ETK61_RS08365	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ETK61_RS08385	COG1595	DNA-templated transcription, initiation
ETK61_RS08405	COG1217	gtp-binding protein TYPA
ETK61_RS08415	COG4896	Protein conserved in bacteria
ETK61_RS08425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ETK61_RS08430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ETK61_RS08435	COG2066	Belongs to the glutaminase family
ETK61_RS08440	COG4838	Belongs to the UPF0358 family
ETK61_RS08445	COG0772	Belongs to the SEDS family
ETK61_RS08450	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ETK61_RS08455	COG1612	heme a metabolic process
ETK61_RS08460	COG0109	protoheme IX farnesyltransferase activity
ETK61_RS08465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ETK61_RS08465	COG2010	Cytochrome c
ETK61_RS08470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ETK61_RS08475	COG1845	cytochrome c oxidase, subunit III
ETK61_RS08480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ETK61_RS08485	COG3336	cytochrome c oxidase
ETK61_RS08495	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ETK61_RS08500	COG2340	Cysteine-rich secretory protein family
ETK61_RS08515	COG3679	Belongs to the UPF0342 family
ETK61_RS08520	COG4471	UPF0298 protein
ETK61_RS08525	COG0742	ribosomal rna small subunit methyltransferase
ETK61_RS08530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ETK61_RS08535	COG3314	Sporulation integral membrane protein YlbJ
ETK61_RS08540	COG1752	Esterase of the alpha-beta hydrolase superfamily
ETK61_RS08545	COG3480	Lon protease (S16) C-terminal proteolytic domain
ETK61_RS08550	COG1323	Belongs to the UPF0348 family
ETK61_RS08560	COG1399	metal-binding, possibly nucleic acid-binding protein
ETK61_RS08575	COG0454	-acetyltransferase
ETK61_RS08580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ETK61_RS08585	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ETK61_RS08590	COG2001	Belongs to the MraZ family
ETK61_RS08595	COG0275	rRNA processing
ETK61_RS08600	COG4839	cell division protein FtsL
ETK61_RS08605	COG0768	penicillin binding
ETK61_RS08610	COG0768	penicillin binding
ETK61_RS08615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ETK61_RS08620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ETK61_RS08625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ETK61_RS08630	COG0772	Belongs to the SEDS family
ETK61_RS08635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK61_RS08640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ETK61_RS08645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ETK61_RS08650	COG3879	Bacterial protein of unknown function (DUF881)
ETK61_RS08655	COG3879	Bacterial protein of unknown function (DUF881)
ETK61_RS08660	COG3856	small basic protein
ETK61_RS08665	COG0849	cell division
ETK61_RS08670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ETK61_RS08675	COG4412	M6 family metalloprotease domain protein
ETK61_RS08675	COG1404	Belongs to the peptidase S8 family
ETK61_RS08685	COG1191	sigma factor activity
ETK61_RS08690	COG1191	sigma factor activity
ETK61_RS08695	COG1119	ATPase activity
ETK61_RS08700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK61_RS08705	COG1873	PFAM PRC-barrel domain
ETK61_RS08710	COG1496	oxidoreductase activity
ETK61_RS08715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ETK61_RS08720	COG1799	cell septum assembly
ETK61_RS08725	COG0762	integral membrane protein
ETK61_RS08730	COG2302	S4 RNA-binding domain
ETK61_RS08735	COG3599	regulation of cell shape
ETK61_RS08740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ETK61_RS08745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK61_RS08750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ETK61_RS08755	COG0564	pseudouridine synthase activity
ETK61_RS08760	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ETK61_RS08765	COG2233	PERMEase
ETK61_RS08770	COG0540	Belongs to the ATCase OTCase family
ETK61_RS08775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ETK61_RS08780	COG0505	Belongs to the CarA family
ETK61_RS08785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ETK61_RS08790	COG0543	2 iron, 2 sulfur cluster binding
ETK61_RS08795	COG0167	dihydroorotate dehydrogenase activity
ETK61_RS08800	COG0284	orotidine-5'-phosphate decarboxylase activity
ETK61_RS08805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ETK61_RS08810	COG0175	sulfate reduction
ETK61_RS08815	COG0306	phosphate transporter
ETK61_RS08820	COG2046	Belongs to the sulfate adenylyltransferase family
ETK61_RS08825	COG0529	Catalyzes the synthesis of activated sulfate
ETK61_RS08830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ETK61_RS08835	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ETK61_RS08840	COG1648	precorrin-2 dehydrogenase activity
ETK61_RS08850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ETK61_RS08855	COG1561	YicC-like family, N-terminal region
ETK61_RS08865	COG0194	GDP metabolic process
ETK61_RS08870	COG1758	RNA polymerase activity
ETK61_RS08875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ETK61_RS08880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ETK61_RS08885	COG0242	peptide deformylase activity
ETK61_RS08890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ETK61_RS08895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ETK61_RS08895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ETK61_RS08900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ETK61_RS08905	COG0631	protein serine/threonine phosphatase activity
ETK61_RS08910	COG0515	serine threonine protein kinase
ETK61_RS08910	COG2815	serine threonine protein kinase
ETK61_RS08915	COG1162	GTPase activity
ETK61_RS08920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ETK61_RS08925	COG1564	THIamine pyrophosphokinase
ETK61_RS08935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ETK61_RS08940	COG1302	Protein conserved in bacteria
ETK61_RS08945	COG1461	Dihydroxyacetone kinase
ETK61_RS08950	COG1760	l-serine dehydratase
ETK61_RS08955	COG1760	l-serine dehydratase
ETK61_RS08960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ETK61_RS08965	COG1349	DNA-binding transcription factor activity
ETK61_RS08965	COG2050	protein possibly involved in aromatic compounds catabolism
ETK61_RS08970	COG0416	fatty acid biosynthetic process
ETK61_RS08975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ETK61_RS08980	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS08990	COG0571	ribonuclease III activity
ETK61_RS08995	COG1196	nuclear chromosome segregation
ETK61_RS09000	COG0552	protein localization to endoplasmic reticulum
ETK61_RS09010	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ETK61_RS09015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ETK61_RS09020	COG0228	four-way junction DNA binding
ETK61_RS09025	COG1837	Belongs to the UPF0109 family
ETK61_RS09035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ETK61_RS09040	COG0336	Belongs to the RNA methyltransferase TrmD family
ETK61_RS09045	COG0335	large ribosomal subunit rRNA binding
ETK61_RS09050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ETK61_RS09055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ETK61_RS09065	COG2257	FlhB HrpN YscU SpaS Family
ETK61_RS09070	COG0045	succinate-CoA ligase (ADP-forming) activity
ETK61_RS09075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ETK61_RS09080	COG0758	DNA mediated transformation
ETK61_RS09085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ETK61_RS09090	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ETK61_RS09095	COG4974	Belongs to the 'phage' integrase family
ETK61_RS09100	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ETK61_RS09105	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ETK61_RS09110	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ETK61_RS09115	COG1815	bacterial-type flagellum-dependent cell motility
ETK61_RS09120	COG1558	bacterial-type flagellum-dependent cell motility
ETK61_RS09125	COG1677	Flagellar hook-basal body complex protein FliE
ETK61_RS09130	COG1766	The M ring may be actively involved in energy transduction
ETK61_RS09135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK61_RS09140	COG1317	bacterial-type flagellum organization
ETK61_RS09145	COG1157	protein secretion by the type III secretion system
ETK61_RS09150	COG2882	bacterial-type flagellum organization
ETK61_RS09155	COG3334	PFAM MgtE intracellular
ETK61_RS09160	COG3144	bacterial-type flagellum assembly
ETK61_RS09165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ETK61_RS09170	COG4786	Flagellar basal body rod
ETK61_RS09175	COG1582	Flagellar protein (FlbD)
ETK61_RS09180	COG1580	Controls the rotational direction of flagella during chemotaxis
ETK61_RS09185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK61_RS09190	COG1776	CheC inhibitor of MCP methylation
ETK61_RS09190	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ETK61_RS09195	COG2201	protein-glutamate methylesterase activity
ETK61_RS09200	COG3190	flagellar
ETK61_RS09205	COG1338	Plays a role in the flagellum-specific transport system
ETK61_RS09210	COG1987	bacterial-type flagellum assembly
ETK61_RS09215	COG1684	flagellar biosynthetic protein fliR
ETK61_RS09220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETK61_RS09225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ETK61_RS09230	COG1419	protein localization to endoplasmic reticulum
ETK61_RS09235	COG0455	bacterial-type flagellum organization
ETK61_RS09240	COG2201	protein-glutamate methylesterase activity
ETK61_RS09245	COG2198	Histidine kinase
ETK61_RS09245	COG0643	Histidine kinase
ETK61_RS09250	COG0835	chemotaxis
ETK61_RS09255	COG1776	CheC inhibitor of MCP methylation
ETK61_RS09260	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ETK61_RS09265	COG1191	sigma factor activity
ETK61_RS09275	COG0052	Belongs to the universal ribosomal protein uS2 family
ETK61_RS09280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ETK61_RS09285	COG0528	UMP kinase activity
ETK61_RS09290	COG0233	cytoplasmic translational termination
ETK61_RS09295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ETK61_RS09300	COG4589	Belongs to the CDS family
ETK61_RS09305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ETK61_RS09310	COG0750	zinc metalloprotease
ETK61_RS09315	COG0442	prolyl-tRNA aminoacylation
ETK61_RS09320	COG2176	DNA-directed DNA polymerase activity
ETK61_RS09325	COG0779	Required for maturation of 30S ribosomal subunits
ETK61_RS09330	COG0195	Participates in both transcription termination and antitermination
ETK61_RS09335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ETK61_RS09340	COG1358	cellular component organization or biogenesis
ETK61_RS09345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ETK61_RS09350	COG1550	Protein conserved in bacteria
ETK61_RS09355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ETK61_RS09360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ETK61_RS09365	COG0196	riboflavin kinase activity
ETK61_RS09370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ETK61_RS09375	COG1185	polyribonucleotide nucleotidyltransferase activity
ETK61_RS09380	COG0726	polysaccharide deacetylase
ETK61_RS09385	COG0612	Peptidase, M16
ETK61_RS09390	COG1873	PFAM PRC-barrel domain
ETK61_RS09395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETK61_RS09400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ETK61_RS09405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ETK61_RS09410	COG0527	aspartate kinase activity
ETK61_RS09415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ETK61_RS09420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ETK61_RS09425	COG0740	serine-type endopeptidase activity
ETK61_RS09435	COG1674	ftsk spoiiie
ETK61_RS09435	COG4980	gas vesicle protein
ETK61_RS09440	COG2188	Transcriptional regulator
ETK61_RS09445	COG2814	Major facilitator Superfamily
ETK61_RS09450	COG0612	Peptidase, M16
ETK61_RS09455	COG0612	Peptidase, M16
ETK61_RS09460	COG0300	oxidoreductase activity
ETK61_RS09475	COG1426	Protein conserved in bacteria
ETK61_RS09480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ETK61_RS09485	COG1546	Belongs to the CinA family
ETK61_RS09485	COG1058	Belongs to the CinA family
ETK61_RS09490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ETK61_RS09495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK61_RS09500	COG1418	mRNA catabolic process
ETK61_RS09505	COG1692	metallophosphoesterase
ETK61_RS09510	COG2359	stage V sporulation protein S
ETK61_RS09515	COG1063	alcohol dehydrogenase
ETK61_RS09520	COG0156	8-amino-7-oxononanoate synthase activity
ETK61_RS09525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETK61_RS09530	COG4550	Control of competence regulator ComK, YlbF/YmcA
ETK61_RS09540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ETK61_RS09545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ETK61_RS09560	COG3226	Transcriptional regulator
ETK61_RS09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS09575	COG1404	Belongs to the peptidase S8 family
ETK61_RS09585	COG4195	phage-related replication protein
ETK61_RS09590	COG1764	response to oxidative stress
ETK61_RS09595	COG2076	Multidrug Resistance protein
ETK61_RS09600	COG2076	Multidrug Resistance protein
ETK61_RS09615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ETK61_RS09620	COG1923	regulation of RNA biosynthetic process
ETK61_RS09635	COG1780	Probably involved in ribonucleotide reductase function
ETK61_RS09640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK61_RS09645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK61_RS09650	COG4112	unkown
ETK61_RS09655	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS09665	COG0464	growth
ETK61_RS09670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ETK61_RS09675	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ETK61_RS09680	COG0789	Transcriptional regulator
ETK61_RS09685	COG0174	glutamine synthetase
ETK61_RS09705	COG4282	regulation of fungal-type cell wall biogenesis
ETK61_RS09720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS09725	COG3328	transposase activity
ETK61_RS09755	COG0135	phosphoribosylanthranilate isomerase activity
ETK61_RS09765	COG3328	transposase activity
ETK61_RS09770	COG2211	Major facilitator Superfamily
ETK61_RS09780	COG1940	carbohydrate kinase activity
ETK61_RS09785	COG2115	Belongs to the xylose isomerase family
ETK61_RS09790	COG1070	Carbohydrate kinase
ETK61_RS09800	COG1525	nuclease
ETK61_RS09805	COG2814	Major facilitator Superfamily
ETK61_RS09810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ETK61_RS09820	COG0756	dUTP diphosphatase activity
ETK61_RS09825	COG3328	transposase activity
ETK61_RS09875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ETK61_RS09890	COG3832	glyoxalase III activity
ETK61_RS09910	COG0531	amino acid
ETK61_RS09940	COG4195	phage-related replication protein
ETK61_RS09950	COG0346	lactoylglutathione lyase activity
ETK61_RS09960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ETK61_RS09965	COG1388	LysM domain
ETK61_RS09970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK61_RS09975	COG4224	UPF0291 protein
ETK61_RS09980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ETK61_RS09990	COG3763	UPF0154 protein
ETK61_RS10000	COG0785	Cytochrome C biogenesis protein
ETK61_RS10005	COG2201	protein-glutamate methylesterase activity
ETK61_RS10010	COG4846	Membrane protein involved in cytochrome C biogenesis
ETK61_RS10020	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK61_RS10035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ETK61_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS10060	COG0824	Thioesterase
ETK61_RS10070	COG4841	protein insertion into membrane
ETK61_RS10075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ETK61_RS10085	COG0187	DNA topoisomerase II activity
ETK61_RS10090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ETK61_RS10100	COG1115	amino acid carrier protein
ETK61_RS10105	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ETK61_RS10120	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK61_RS10125	COG2246	polysaccharide biosynthetic process
ETK61_RS10130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ETK61_RS10135	COG0586	Pfam SNARE associated Golgi protein
ETK61_RS10140	COG2404	hydrolase activity, acting on ester bonds
ETK61_RS10145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ETK61_RS10150	COG1024	Enoyl-CoA hydratase
ETK61_RS10155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ETK61_RS10160	COG0511	ligase activity, forming carbon-carbon bonds
ETK61_RS10165	COG0439	Biotin carboxylase
ETK61_RS10170	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS10175	COG1960	acyl-CoA dehydrogenase activity
ETK61_RS10190	COG1649	PFAM Uncharacterised BCR, COG1649
ETK61_RS10205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS10210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS10215	COG2027	D-alanyl-D-alanine carboxypeptidase
ETK61_RS10220	COG2017	converts alpha-aldose to the beta-anomer
ETK61_RS10225	COG0534	Mate efflux family protein
ETK61_RS10240	COG0582	viral genome integration into host DNA
ETK61_RS10245	COG0166	Belongs to the GPI family
ETK61_RS10250	COG0405	Gamma-glutamyltransferase
ETK61_RS10255	COG0583	DNA-binding transcription factor activity
ETK61_RS10260	COG0604	alcohol dehydrogenase
ETK61_RS10265	COG0493	'glutamate synthase
ETK61_RS10270	COG0070	glutamate synthase
ETK61_RS10270	COG0069	glutamate synthase activity
ETK61_RS10270	COG0067	glutamate synthase
ETK61_RS10275	COG0583	DNA-binding transcription factor activity
ETK61_RS10280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ETK61_RS10285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK61_RS10295	COG0300	oxidoreductase activity
ETK61_RS10300	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ETK61_RS10310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ETK61_RS10325	COG1131	(ABC) transporter
ETK61_RS10335	COG2814	Major facilitator Superfamily
ETK61_RS10340	COG1070	Carbohydrate kinase
ETK61_RS10345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ETK61_RS10350	COG0243	molybdopterin cofactor binding
ETK61_RS10385	COG2368	4-hydroxyphenylacetate
ETK61_RS10390	COG4305	rare lipoprotein A
ETK61_RS10395	COG3619	membrane
ETK61_RS10400	COG3866	Pectate lyase
ETK61_RS10405	COG2135	peptidase activity
ETK61_RS10440	COG2720	vancomycin resistance protein
ETK61_RS10455	COG3739	integral membrane protein
ETK61_RS10460	COG0583	DNA-binding transcription factor activity
ETK61_RS10465	COG0697	spore germination
ETK61_RS10475	COG0693	protein deglycase activity
ETK61_RS10480	COG2367	Beta-lactamase
ETK61_RS10500	COG0574	Belongs to the PEP-utilizing enzyme family
ETK61_RS10500	COG3848	Pyruvate phosphate dikinase
ETK61_RS10505	COG0726	polysaccharide deacetylase
ETK61_RS10515	COG2314	TM2 domain
ETK61_RS10520	COG1396	sequence-specific DNA binding
ETK61_RS10640	COG0457	Tetratricopeptide repeat
ETK61_RS10665	COG3328	transposase activity
ETK61_RS10685	COG0457	Tetratricopeptide repeat
ETK61_RS10700	COG5444	nuclease activity
ETK61_RS10705	COG4282	regulation of fungal-type cell wall biogenesis
ETK61_RS10710	COG1231	oxidoreductase activity
ETK61_RS10720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS10725	COG0662	Cupin 2, conserved barrel domain protein
ETK61_RS10725	COG2207	Transcriptional regulator
ETK61_RS10730	COG0456	acetyltransferase
ETK61_RS10735	COG1309	transcriptional regulator
ETK61_RS10740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS10745	COG3708	Transcriptional regulator
ETK61_RS10750	COG2378	regulation of single-species biofilm formation
ETK61_RS10760	COG0640	Transcriptional regulator
ETK61_RS10765	COG0741	lytic transglycosylase activity
ETK61_RS10770	COG2322	membrane
ETK61_RS10785	COG1619	proteins homologs of microcin C7 resistance protein MccF
ETK61_RS10790	COG3239	Fatty acid desaturase
ETK61_RS10795	COG4585	Histidine kinase
ETK61_RS10800	COG2197	response regulator
ETK61_RS10805	COG1388	LysM domain
ETK61_RS10805	COG3584	3D domain protein
ETK61_RS10810	COG0514	ATP-dependent DNA helicase (RecQ)
ETK61_RS10825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ETK61_RS10830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK61_RS10845	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK61_RS10870	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS10875	COG1657	PFAM Prenyltransferase squalene oxidase
ETK61_RS10880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ETK61_RS10885	COG0733	neurotransmitter:sodium symporter activity
ETK61_RS10890	COG0385	Bile acid
ETK61_RS10895	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK61_RS10900	COG0567	Dehydrogenase, E1 component
ETK61_RS10905	COG4548	von Willebrand factor, type A
ETK61_RS10910	COG0714	Associated with various cellular activities
ETK61_RS10915	COG2032	superoxide dismutase activity
ETK61_RS10920	COG1388	LysM domain
ETK61_RS10920	COG0791	NLP P60 protein
ETK61_RS10925	COG1819	glycosyl
ETK61_RS10930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ETK61_RS10935	COG0534	Mate efflux family protein
ETK61_RS10940	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS10945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK61_RS10950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK61_RS10960	COG2962	Rard protein
ETK61_RS10975	COG2610	gluconate transmembrane transporter activity
ETK61_RS10980	COG1942	4-Oxalocrotonate Tautomerase
ETK61_RS10985	COG1733	regulation of RNA biosynthetic process
ETK61_RS10990	COG0778	Nitroreductase
ETK61_RS11000	COG0400	carboxylic ester hydrolase activity
ETK61_RS11005	COG0346	lactoylglutathione lyase activity
ETK61_RS11015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ETK61_RS11025	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS11025	COG0793	Belongs to the peptidase S41A family
ETK61_RS11030	COG2226	methyltransferase
ETK61_RS11040	COG1876	peptidase activity
ETK61_RS11045	COG0813	purine-nucleoside phosphorylase activity
ETK61_RS11060	COG0671	phosphoesterase, PA-phosphatase related
ETK61_RS11085	COG4479	Belongs to the UPF0346 family
ETK61_RS11095	COG1509	lysine 2,3-aminomutase activity
ETK61_RS11100	COG0456	acetyltransferase
ETK61_RS11105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK61_RS11110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ETK61_RS11115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ETK61_RS11120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK61_RS11135	COG0456	acetyltransferase
ETK61_RS11140	COG0463	Glycosyl transferase, family 2
ETK61_RS11155	COG4641	Protein conserved in bacteria
ETK61_RS11160	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ETK61_RS11165	COG1086	Polysaccharide biosynthesis protein
ETK61_RS11175	COG3331	DNA recombination
ETK61_RS11235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ETK61_RS11305	COG0756	dUTP diphosphatase activity
ETK61_RS11315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS11340	COG1372	Participates in initiation and elongation during chromosome replication
ETK61_RS11340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ETK61_RS11345	COG1780	Probably involved in ribonucleotide reductase function
ETK61_RS11430	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ETK61_RS11435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ETK61_RS11450	COG3584	3D domain protein
ETK61_RS11455	COG0587	DNA-directed DNA polymerase activity
ETK61_RS11460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ETK61_RS11465	COG0358	DNA primase activity
ETK61_RS11470	COG0305	Participates in initiation and elongation during chromosome replication
ETK61_RS11480	COG2887	Belongs to the helicase family. UvrD subfamily
ETK61_RS11530	COG1793	dna ligase
ETK61_RS11540	COG5484	DNA packaging
ETK61_RS11540	COG3728	DNA packaging
ETK61_RS11550	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
ETK61_RS11585	COG4474	Belongs to the UPF0398 family
ETK61_RS11650	COG3655	Transcriptional regulator
ETK61_RS11810	COG0776	regulation of translation
ETK61_RS11845	COG4373	Mu-like prophage FluMu protein gp28
ETK61_RS11945	COG0582	viral genome integration into host DNA
ETK61_RS11960	COG1196	nuclear chromosome segregation
ETK61_RS11960	COG0741	lytic transglycosylase activity
ETK61_RS11960	COG0739	heme binding
ETK61_RS11990	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS12005	COG0457	Tetratricopeptide repeat
ETK61_RS12025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK61_RS12050	COG5444	nuclease activity
ETK61_RS12060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK61_RS12065	COG1086	Polysaccharide biosynthesis protein
ETK61_RS12070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK61_RS12075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK61_RS12080	COG1846	Transcriptional regulator
ETK61_RS12085	COG0534	Mate efflux family protein
ETK61_RS12095	COG4698	Protein conserved in bacteria
ETK61_RS12100	COG2755	lipolytic protein G-D-S-L family
ETK61_RS12105	COG1999	signal sequence binding
ETK61_RS12115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ETK61_RS12120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ETK61_RS12125	COG1272	protein, Hemolysin III
ETK61_RS12130	COG0204	Acyl-transferase
ETK61_RS12135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ETK61_RS12140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ETK61_RS12150	COG2521	methyltransferase
ETK61_RS12150	COG2136	Putative SAM-dependent methyltransferase
ETK61_RS12160	COG0129	dihydroxy-acid dehydratase activity
ETK61_RS12165	COG1413	lyase activity
ETK61_RS12170	COG1418	mRNA catabolic process
ETK61_RS12175	COG0386	Belongs to the glutathione peroxidase family
ETK61_RS12180	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ETK61_RS12185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ETK61_RS12195	COG1278	Cold shock
ETK61_RS12215	COG0328	RNA-DNA hybrid ribonuclease activity
ETK61_RS12220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ETK61_RS12225	COG0328	RNA-DNA hybrid ribonuclease activity
ETK61_RS12235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK61_RS12250	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ETK61_RS12260	COG1755	Isoprenylcysteine carboxyl methyltransferase
ETK61_RS12265	COG3424	synthase
ETK61_RS12270	COG2233	PERMEase
ETK61_RS12275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK61_RS12280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ETK61_RS12290	COG0800	Aldolase
ETK61_RS12295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK61_RS12300	COG1609	Transcriptional regulator
ETK61_RS12305	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ETK61_RS12310	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS12330	COG0116	Belongs to the methyltransferase superfamily
ETK61_RS12345	COG4474	Belongs to the UPF0398 family
ETK61_RS12365	COG1205	dead DEAH box helicase
ETK61_RS12365	COG1111	helicase
ETK61_RS12370	COG2190	(PTS) system
ETK61_RS12375	COG0071	Belongs to the small heat shock protein (HSP20) family
ETK61_RS12410	COG3331	DNA recombination
ETK61_RS12415	COG4499	WXG100 protein secretion system (Wss), protein YukC
ETK61_RS12415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK61_RS12425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ETK61_RS12430	COG3935	DnaD domain protein
ETK61_RS12435	COG0017	Asparaginyl-tRNA synthetase
ETK61_RS12440	COG0436	Aminotransferase
ETK61_RS12445	COG5353	protein conserved in bacteria
ETK61_RS12455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ETK61_RS12455	COG1199	ATP-dependent helicase activity
ETK61_RS12460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ETK61_RS12465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ETK61_RS12470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ETK61_RS12475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ETK61_RS12475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ETK61_RS12480	COG0617	tRNA 3'-terminal CCA addition
ETK61_RS12485	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS12490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ETK61_RS12495	COG1803	Methylglyoxal synthase
ETK61_RS12500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ETK61_RS12505	COG1694	Mazg nucleotide pyrophosphohydrolase
ETK61_RS12510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS12520	COG4347	Protein of unknown function (DUF1405)
ETK61_RS12525	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ETK61_RS12525	COG2010	Cytochrome c
ETK61_RS12530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ETK61_RS12535	COG0723	plastoquinol--plastocyanin reductase activity
ETK61_RS12545	COG5582	Belongs to the UPF0302 family
ETK61_RS12550	COG0457	Tetratricopeptide repeat
ETK61_RS12555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ETK61_RS12560	COG0287	Prephenate dehydrogenase
ETK61_RS12570	COG0159	tryptophan synthase activity
ETK61_RS12575	COG0133	tryptophan synthase activity
ETK61_RS12580	COG0135	phosphoribosylanthranilate isomerase activity
ETK61_RS12590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ETK61_RS12595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ETK61_RS12600	COG4401	Chorismate mutase type I
ETK61_RS12605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ETK61_RS12610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ETK61_RS12615	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ETK61_RS12620	COG0105	UTP biosynthetic process
ETK61_RS12625	COG0142	geranyltranstransferase activity
ETK61_RS12630	COG2226	methyltransferase
ETK61_RS12635	COG0142	geranyltranstransferase activity
ETK61_RS12645	COG0302	gtp cyclohydrolase
ETK61_RS12650	COG0776	regulation of translation
ETK61_RS12655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ETK61_RS12670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ETK61_RS12675	COG1160	GTP binding
ETK61_RS12700	COG1304	FMN binding
ETK61_RS12705	COG0539	negative regulation of cytoplasmic translation
ETK61_RS12710	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ETK61_RS12720	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ETK61_RS12725	COG2959	enzyme of heme biosynthesis
ETK61_RS12730	COG3773	Cell wall hydrolase
ETK61_RS12730	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS12735	COG2339	peptidase activity
ETK61_RS12740	COG0492	ferredoxin-NADP+ reductase activity
ETK61_RS12745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETK61_RS12750	COG4862	establishment of competence for transformation
ETK61_RS12755	COG1408	metallophosphoesterase
ETK61_RS12765	COG1388	LysM domain
ETK61_RS12770	COG1266	CAAX protease self-immunity
ETK61_RS12775	COG0514	ATP-dependent DNA helicase (RecQ)
ETK61_RS12780	COG4955	Helix-turn-helix domain
ETK61_RS12785	COG1141	Ferredoxin
ETK61_RS12790	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ETK61_RS12795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ETK61_RS12800	COG0710	3-dehydroquinate dehydratase activity
ETK61_RS12810	COG1595	DNA-templated transcription, initiation
ETK61_RS12815	COG5002	protein histidine kinase activity
ETK61_RS12820	COG0745	RESPONSE REGULATOR receiver
ETK61_RS12825	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ETK61_RS12830	COG1333	cytochrome c biogenesis protein
ETK61_RS12835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS12840	COG1187	pseudouridine synthase activity
ETK61_RS12845	COG0700	Nucleoside recognition
ETK61_RS12850	COG2715	membrane protein required for spore maturation
ETK61_RS12855	COG1686	Belongs to the peptidase S11 family
ETK61_RS12865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ETK61_RS12870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ETK61_RS12875	COG1547	Domain of unknown function (DUF309)
ETK61_RS12880	COG0456	acetyltransferase
ETK61_RS12885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ETK61_RS12890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ETK61_RS12890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ETK61_RS12895	COG0307	riboflavin synthase, alpha
ETK61_RS12900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETK61_RS12900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ETK61_RS12910	COG0681	Belongs to the peptidase S26 family
ETK61_RS12920	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ETK61_RS12930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ETK61_RS12940	COG4086	secreted protein
ETK61_RS12945	COG0019	diaminopimelate decarboxylase activity
ETK61_RS12950	COG0697	spore germination
ETK61_RS12965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ETK61_RS12985	COG1191	sigma factor activity
ETK61_RS12990	COG2172	sigma factor antagonist activity
ETK61_RS12995	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS13000	COG1686	Belongs to the peptidase S11 family
ETK61_RS13005	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ETK61_RS13010	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ETK61_RS13015	COG4974	Belongs to the 'phage' integrase family
ETK61_RS13025	COG0735	belongs to the Fur family
ETK61_RS13030	COG1300	Membrane
ETK61_RS13040	COG0281	malic enzyme
ETK61_RS13045	COG1757	Na H antiporter
ETK61_RS13050	COG1027	Aspartate ammonia-lyase
ETK61_RS13055	COG0252	asparaginase activity
ETK61_RS13060	COG1396	sequence-specific DNA binding
ETK61_RS13065	COG1379	DNA repair
ETK61_RS13070	COG0494	nUDIX hydrolase
ETK61_RS13080	COG0667	Aldo Keto reductase
ETK61_RS13095	COG1073	alpha beta
ETK61_RS13105	COG4918	Iron-sulphur cluster biosynthesis
ETK61_RS13110	COG0456	acetyltransferase
ETK61_RS13110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ETK61_RS13115	COG2329	Antibiotic biosynthesis monooxygenase
ETK61_RS13120	COG0456	acetyltransferase
ETK61_RS13130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK61_RS13140	COG2211	Major facilitator Superfamily
ETK61_RS13145	COG0346	lactoylglutathione lyase activity
ETK61_RS13150	COG1072	(Pantothenic acid kinase))
ETK61_RS13155	COG3048	D-serine ammonia-lyase activity
ETK61_RS13160	COG0300	oxidoreductase activity
ETK61_RS13165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS13170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK61_RS13175	COG4187	Peptidase family M20/M25/M40
ETK61_RS13180	COG1902	pentaerythritol trinitrate reductase activity
ETK61_RS13185	COG0596	Alpha beta hydrolase
ETK61_RS13195	COG1234	tRNA 3'-trailer cleavage
ETK61_RS13200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ETK61_RS13205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ETK61_RS13210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK61_RS13220	COG0706	membrane insertase activity
ETK61_RS13225	COG3361	conserved protein (COG2071)
ETK61_RS13230	COG2195	Cleaves the N-terminal amino acid of tripeptides
ETK61_RS13235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ETK61_RS13240	COG0346	lactoylglutathione lyase activity
ETK61_RS13245	COG1376	ErfK ybiS ycfS ynhG family protein
ETK61_RS13250	COG4129	membrane
ETK61_RS13255	COG1126	abc transporter atp-binding protein
ETK61_RS13260	COG0765	amino acid transport
ETK61_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS13275	COG1597	lipid kinase activity
ETK61_RS13280	COG2814	Major facilitator Superfamily
ETK61_RS13285	COG0789	Transcriptional regulator
ETK61_RS13285	COG4978	Transcriptional regulator
ETK61_RS13290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ETK61_RS13295	COG0022	dehydrogenase e1 component
ETK61_RS13300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ETK61_RS13305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ETK61_RS13310	COG3426	butyrate kinase activity
ETK61_RS13315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETK61_RS13320	COG0280	phosphate acetyltransferase
ETK61_RS13325	COG3829	transcription factor binding
ETK61_RS13325	COG3290	protein histidine kinase activity
ETK61_RS13335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ETK61_RS13340	COG2079	MmgE PrpD family protein
ETK61_RS13345	COG0372	Belongs to the citrate synthase family
ETK61_RS13350	COG1960	acyl-CoA dehydrogenase activity
ETK61_RS13355	COG1250	3-hydroxyacyl-CoA dehydrogenase
ETK61_RS13360	COG0183	Belongs to the thiolase family
ETK61_RS13365	COG0584	glycerophosphoryl diester phosphodiesterase
ETK61_RS13370	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS13385	COG1902	pentaerythritol trinitrate reductase activity
ETK61_RS13390	COG0745	RESPONSE REGULATOR receiver
ETK61_RS13400	COG0750	zinc metalloprotease
ETK61_RS13405	COG0497	DNA recombination
ETK61_RS13410	COG1438	arginine binding
ETK61_RS13415	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ETK61_RS13420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ETK61_RS13425	COG0142	geranyltranstransferase activity
ETK61_RS13430	COG1722	exodeoxyribonuclease VII activity
ETK61_RS13435	COG1570	exodeoxyribonuclease VII activity
ETK61_RS13440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ETK61_RS13445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ETK61_RS13450	COG1302	Protein conserved in bacteria
ETK61_RS13455	COG0439	Biotin carboxylase
ETK61_RS13460	COG0511	ligase activity, forming carbon-carbon bonds
ETK61_RS13500	COG3854	ATPases associated with a variety of cellular activities
ETK61_RS13510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ETK61_RS13515	COG0006	proline dipeptidase activity
ETK61_RS13520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ETK61_RS13530	COG3872	metal-dependent enzyme
ETK61_RS13540	COG1752	Esterase of the alpha-beta hydrolase superfamily
ETK61_RS13545	COG1321	iron dependent repressor
ETK61_RS13550	COG0095	Lipoate-protein ligase
ETK61_RS13555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK61_RS13560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ETK61_RS13565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ETK61_RS13570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ETK61_RS13575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ETK61_RS13590	COG1396	sequence-specific DNA binding
ETK61_RS13600	COG0681	Belongs to the peptidase S26 family
ETK61_RS13625	COG4940	Competence protein ComGF
ETK61_RS13635	COG4970	Tfp pilus assembly protein FimT
ETK61_RS13640	COG4537	Required for transformation and DNA binding
ETK61_RS13645	COG1459	type II secretion system
ETK61_RS13650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ETK61_RS13660	COG0598	Magnesium transport protein CorA
ETK61_RS13665	COG1253	flavin adenine dinucleotide binding
ETK61_RS13670	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS13680	COG1393	Belongs to the ArsC family
ETK61_RS13690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS13700	COG0011	TIGRFAM Protein of
ETK61_RS13710	COG2866	Carboxypeptidase
ETK61_RS13715	COG1368	sulfuric ester hydrolase activity
ETK61_RS13720	COG1940	carbohydrate kinase activity
ETK61_RS13725	COG4483	Protein conserved in bacteria
ETK61_RS13730	COG0705	Rhomboid family
ETK61_RS13730	COG0457	Tetratricopeptide repeat
ETK61_RS13740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ETK61_RS13750	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS13765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ETK61_RS13770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETK61_RS13775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ETK61_RS13780	COG0581	inorganic phosphate transmembrane transporter activity
ETK61_RS13785	COG0573	inorganic phosphate transmembrane transporter activity
ETK61_RS13790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ETK61_RS13795	COG0768	penicillin binding
ETK61_RS13800	COG0477	Major facilitator Superfamily
ETK61_RS13805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ETK61_RS13810	COG2839	Protein conserved in bacteria
ETK61_RS13815	COG5521	maltodextrose utilization protein MalA
ETK61_RS13820	COG1388	LysM domain
ETK61_RS13825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ETK61_RS13830	COG4709	membrane
ETK61_RS13835	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ETK61_RS13840	COG0735	belongs to the Fur family
ETK61_RS13845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS13855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ETK61_RS13860	COG0513	Belongs to the DEAD box helicase family
ETK61_RS13870	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ETK61_RS13880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ETK61_RS13885	COG2384	SAM-dependent methyltransferase
ETK61_RS13890	COG2010	Cytochrome c
ETK61_RS13895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ETK61_RS13900	COG0358	DNA primase activity
ETK61_RS13905	COG1671	Belongs to the UPF0178 family
ETK61_RS13910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ETK61_RS13915	COG0517	IMP dehydrogenase activity
ETK61_RS13920	COG0751	glycine-tRNA ligase activity
ETK61_RS13925	COG0752	glycyl-tRNA synthetase alpha subunit
ETK61_RS13930	COG1381	Involved in DNA repair and RecF pathway recombination
ETK61_RS13940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ETK61_RS13945	COG0295	cytidine deaminase activity
ETK61_RS13950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ETK61_RS13955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ETK61_RS13960	COG1480	7TM receptor with intracellular HD hydrolase
ETK61_RS13965	COG1702	phosphate starvation-inducible protein PhoH
ETK61_RS13970	COG0561	phosphatase activity
ETK61_RS13985	COG4864	UPF0365 protein
ETK61_RS13990	COG1030	water channel activity
ETK61_RS13995	COG1610	YqeY-like protein
ETK61_RS14005	COG1283	sodium-dependent phosphate transmembrane transporter activity
ETK61_RS14010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ETK61_RS14015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ETK61_RS14020	COG2264	protein methyltransferase activity
ETK61_RS14025	COG0484	heat shock protein binding
ETK61_RS14030	COG0443	Heat shock 70 kDa protein
ETK61_RS14035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ETK61_RS14040	COG1420	regulation of RNA biosynthetic process
ETK61_RS14045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ETK61_RS14050	COG0481	GTPase activity
ETK61_RS14060	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS14065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ETK61_RS14070	COG0268	Binds directly to 16S ribosomal RNA
ETK61_RS14075	COG1466	dna polymerase III delta subunit
ETK61_RS14095	COG2131	deaminase
ETK61_RS14100	COG1555	photosystem II stabilization
ETK61_RS14100	COG1596	polysaccharide export
ETK61_RS14105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ETK61_RS14110	COG2226	methyltransferase
ETK61_RS14115	COG0799	negative regulation of ribosome biogenesis
ETK61_RS14120	COG1713	HD superfamily hydrolase involved in NAD metabolism
ETK61_RS14125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ETK61_RS14130	COG1534	Rna-binding protein
ETK61_RS14135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ETK61_RS14140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ETK61_RS14145	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ETK61_RS14155	COG2755	lipolytic protein G-D-S-L family
ETK61_RS14160	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS14160	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS14165	COG0398	Pfam SNARE associated Golgi protein
ETK61_RS14170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ETK61_RS14180	COG3209	COG3209 Rhs family protein
ETK61_RS14195	COG3328	transposase activity
ETK61_RS14210	COG4124	Belongs to the glycosyl hydrolase 26 family
ETK61_RS14215	COG0730	response to heat
ETK61_RS14220	COG0425	Belongs to the sulfur carrier protein TusA family
ETK61_RS14225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK61_RS14225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS14235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK61_RS14235	COG0425	Belongs to the sulfur carrier protein TusA family
ETK61_RS14245	COG2210	Belongs to the sulfur carrier protein TusA family
ETK61_RS14250	COG1937	Protein conserved in bacteria
ETK61_RS14265	COG0662	Cupin 2, conserved barrel domain protein
ETK61_RS14280	COG4978	Transcriptional regulator
ETK61_RS14280	COG0789	Transcriptional regulator
ETK61_RS14285	COG2814	Major facilitator Superfamily
ETK61_RS14290	COG0456	acetyltransferase
ETK61_RS14295	COG1253	flavin adenine dinucleotide binding
ETK61_RS14305	COG0697	spore germination
ETK61_RS14310	COG0583	DNA-binding transcription factor activity
ETK61_RS14315	COG2072	flavoprotein involved in K transport
ETK61_RS14320	COG1230	cation diffusion facilitator family transporter
ETK61_RS14325	COG1942	4-Oxalocrotonate Tautomerase
ETK61_RS14330	COG0583	DNA-binding transcription factor activity
ETK61_RS14340	COG1114	Component of the transport system for branched-chain amino acids
ETK61_RS14345	COG1687	branched-chain amino acid
ETK61_RS14355	COG1522	sequence-specific DNA binding
ETK61_RS14365	COG2124	cytochrome p450
ETK61_RS14375	COG1335	isochorismatase
ETK61_RS14390	COG2318	DinB family
ETK61_RS14400	COG2070	2-Nitropropane dioxygenase
ETK61_RS14415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ETK61_RS14435	COG3443	Belongs to the bacterial solute-binding protein 9 family
ETK61_RS14440	COG1595	DNA-templated transcription, initiation
ETK61_RS14445	COG0667	Aldo Keto reductase
ETK61_RS14450	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS14455	COG5566	PFAM Mor transcription activator
ETK61_RS14460	COG0596	Alpha beta hydrolase
ETK61_RS14465	COG4991	sh3 domain protein
ETK61_RS14470	COG4991	sh3 domain protein
ETK61_RS14480	COG0346	lactoylglutathione lyase activity
ETK61_RS14490	COG5577	PFAM Coat F domain
ETK61_RS14495	COG1063	alcohol dehydrogenase
ETK61_RS14505	COG5577	PFAM Coat F domain
ETK61_RS14510	COG0789	Transcriptional regulator
ETK61_RS14520	COG1064	alcohol dehydrogenase
ETK61_RS14525	COG0693	protein deglycase activity
ETK61_RS14530	COG1621	beta-fructofuranosidase activity
ETK61_RS14535	COG3716	PTS system mannose fructose sorbose family IID component
ETK61_RS14540	COG3715	PTS system
ETK61_RS14545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS14550	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS14555	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ETK61_RS14555	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ETK61_RS14565	COG1113	amino acid transport
ETK61_RS14570	COG1280	lysine exporter protein (LysE YggA)
ETK61_RS14575	COG1378	Sugar-specific transcriptional regulator TrmB
ETK61_RS14580	COG1595	DNA-templated transcription, initiation
ETK61_RS14590	COG2755	lipolytic protein G-D-S-L family
ETK61_RS14590	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ETK61_RS14600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ETK61_RS14600	COG2124	cytochrome p450
ETK61_RS14605	COG1309	transcriptional regulator
ETK61_RS14610	COG2226	methyltransferase
ETK61_RS14625	COG2116	formate transmembrane transporter activity
ETK61_RS14630	COG5609	conserved protein (DUF2294)
ETK61_RS14635	COG3383	formate dehydrogenase (NAD+) activity
ETK61_RS14640	COG2427	Protein of unknown function (DUF1641)
ETK61_RS14650	COG0626	cystathionine gamma-synthase activity
ETK61_RS14655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK61_RS14660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ETK61_RS14665	COG2226	methyltransferase
ETK61_RS14680	COG0768	penicillin binding
ETK61_RS14685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ETK61_RS14690	COG0572	uridine kinase
ETK61_RS14695	COG0826	peptidase U32
ETK61_RS14700	COG0826	peptidase U32
ETK61_RS14705	COG4122	O-methyltransferase activity
ETK61_RS14710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ETK61_RS14715	COG3906	Belongs to the UPF0473 family
ETK61_RS14720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ETK61_RS14725	COG4472	Bacterial protein of unknown function (DUF965)
ETK61_RS14730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ETK61_RS14735	COG0628	permease
ETK61_RS14740	COG1126	abc transporter atp-binding protein
ETK61_RS14745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS14750	COG0765	amino acid transport
ETK61_RS14755	COG0765	amino acid transport
ETK61_RS14770	COG3881	PFAM PRC-barrel domain
ETK61_RS14775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ETK61_RS14780	COG0457	Tetratricopeptide repeat
ETK61_RS14785	COG0482	sulfurtransferase activity
ETK61_RS14790	COG1104	cysteine desulfurase activity
ETK61_RS14795	COG1959	2 iron, 2 sulfur cluster binding
ETK61_RS14800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ETK61_RS14805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ETK61_RS14815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ETK61_RS14820	COG0124	histidyl-tRNA synthetase
ETK61_RS14830	COG3103	Sh3 type 3 domain protein
ETK61_RS14830	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS14830	COG4991	sh3 domain protein
ETK61_RS14835	COG1490	D-aminoacyl-tRNA deacylase activity
ETK61_RS14840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ETK61_RS14845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ETK61_RS14850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ETK61_RS14850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ETK61_RS14855	COG5416	Lipopolysaccharide assembly protein A domain
ETK61_RS14860	COG0490	domain, Protein
ETK61_RS14865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETK61_RS14865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ETK61_RS14875	COG2244	polysaccharide biosynthetic process
ETK61_RS14880	COG2323	membrane
ETK61_RS14895	COG1862	Preprotein translocase
ETK61_RS14900	COG0343	queuine tRNA-ribosyltransferase activity
ETK61_RS14905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ETK61_RS14915	COG2255	four-way junction helicase activity
ETK61_RS14920	COG0632	four-way junction helicase activity
ETK61_RS14930	COG2814	Major facilitator Superfamily
ETK61_RS14935	COG0673	inositol 2-dehydrogenase activity
ETK61_RS14940	COG2112	serine threonine protein kinase
ETK61_RS14960	COG1115	amino acid carrier protein
ETK61_RS14965	COG0217	transcriptional regulatory protein
ETK61_RS14975	COG1388	LysM domain
ETK61_RS14980	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ETK61_RS14985	COG0157	Belongs to the NadC ModD family
ETK61_RS14990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ETK61_RS14995	COG1104	cysteine desulfurase activity
ETK61_RS15000	COG1827	regulation of RNA biosynthetic process
ETK61_RS15005	COG0077	Prephenate dehydratase
ETK61_RS15010	COG4492	Belongs to the UPF0735 family
ETK61_RS15015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ETK61_RS15020	COG3290	protein histidine kinase activity
ETK61_RS15030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ETK61_RS15035	COG2868	ribosomal protein
ETK61_RS15040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ETK61_RS15045	COG1994	Peptidase M50
ETK61_RS15050	COG0739	heme binding
ETK61_RS15055	COG2894	cell division
ETK61_RS15060	COG0850	regulation of cytokinetic process
ETK61_RS15065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ETK61_RS15075	COG1077	Cell shape determining protein MreB Mrl
ETK61_RS15080	COG2003	Belongs to the UPF0758 family
ETK61_RS15085	COG0424	maF-like protein
ETK61_RS15095	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ETK61_RS15100	COG0285	dihydrofolate synthase activity
ETK61_RS15105	COG0525	valine-tRNA ligase activity
ETK61_RS15115	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK61_RS15120	COG1388	LysM domain
ETK61_RS15125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ETK61_RS15130	COG0113	porphobilinogen synthase activity
ETK61_RS15135	COG1587	Uroporphyrinogen-III synthase
ETK61_RS15140	COG0181	hydroxymethylbilane synthase activity
ETK61_RS15145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ETK61_RS15150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ETK61_RS15160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ETK61_RS15165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ETK61_RS15170	COG1067	ATP-dependent peptidase activity
ETK61_RS15170	COG0470	DNA polymerase III
ETK61_RS15175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ETK61_RS15180	COG0544	peptidyl-prolyl cis-trans isomerase activity
ETK61_RS15185	COG0457	Tetratricopeptide repeat
ETK61_RS15185	COG1477	protein flavinylation
ETK61_RS15190	COG0066	3-isopropylmalate dehydratase activity
ETK61_RS15195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ETK61_RS15200	COG0473	3-isopropylmalate dehydrogenase activity
ETK61_RS15205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ETK61_RS15210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ETK61_RS15215	COG0440	acetolactate synthase activity
ETK61_RS15220	COG0028	Belongs to the TPP enzyme family
ETK61_RS15240	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ETK61_RS15255	COG0622	Phosphoesterase
ETK61_RS15260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ETK61_RS15265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ETK61_RS15270	COG5401	PFAM Sporulation and spore germination
ETK61_RS15275	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ETK61_RS15280	COG1846	Transcriptional regulator
ETK61_RS15290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK61_RS15310	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS15310	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS15370	COG0791	NLP P60 protein
ETK61_RS15370	COG1388	LysM domain
ETK61_RS15375	COG5280	Phage tail tape measure protein TP901
ETK61_RS15375	COG3953	SLT domain
ETK61_RS15440	COG5484	DNA packaging
ETK61_RS15465	COG1595	DNA-templated transcription, initiation
ETK61_RS15510	COG1484	DNA-dependent DNA replication
ETK61_RS15515	COG3935	DnaD domain protein
ETK61_RS15520	COG3723	Recombinational DNA repair protein, rece pathway
ETK61_RS15525	COG5377	YqaJ viral recombinase family
ETK61_RS15555	COG3645	SOS response
ETK61_RS15555	COG3646	Phage regulatory protein
ETK61_RS15565	COG3620	sequence-specific DNA binding
ETK61_RS15575	COG2856	Zn peptidase
ETK61_RS15580	COG2197	response regulator
ETK61_RS15585	COG0824	Thioesterase
ETK61_RS15590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ETK61_RS15595	COG1053	succinate dehydrogenase
ETK61_RS15600	COG2009	succinate dehydrogenase
ETK61_RS15605	COG1719	4-vinyl reductase, 4VR
ETK61_RS15610	COG0527	aspartate kinase activity
ETK61_RS15620	COG0322	excinuclease ABC activity
ETK61_RS15625	COG3118	belongs to the thioredoxin family
ETK61_RS15630	COG3534	alpha-L-arabinofuranosidase
ETK61_RS15635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ETK61_RS15640	COG2086	electron transfer activity
ETK61_RS15645	COG1024	Enoyl-CoA hydratase
ETK61_RS15650	COG1309	transcriptional regulator
ETK61_RS15655	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS15660	COG3766	membrane
ETK61_RS15665	COG1193	negative regulation of DNA recombination
ETK61_RS15670	COG1796	DNA polymerase
ETK61_RS15670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETK61_RS15675	COG1286	toxin biosynthetic process
ETK61_RS15680	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ETK61_RS15685	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ETK61_RS15690	COG0072	phenylalanine-tRNA ligase activity
ETK61_RS15690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS15695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ETK61_RS15705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ETK61_RS15715	COG3835	regulator
ETK61_RS15720	COG0277	FAD linked oxidase domain protein
ETK61_RS15725	COG0247	lactate metabolic process
ETK61_RS15730	COG0346	lactoylglutathione lyase activity
ETK61_RS15740	COG1966	Carbon starvation protein
ETK61_RS15745	COG3534	alpha-L-arabinofuranosidase
ETK61_RS15750	COG0395	ABC-type sugar transport system, permease component
ETK61_RS15755	COG1175	transmembrane transport
ETK61_RS15760	COG1653	transport
ETK61_RS15765	COG0371	Dehydrogenase
ETK61_RS15770	COG0647	UMP catabolic process
ETK61_RS15775	COG0235	Class ii aldolase
ETK61_RS15780	COG1069	ribulokinase activity
ETK61_RS15785	COG2160	L-arabinose isomerase activity
ETK61_RS15790	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK61_RS15795	COG1363	Peptidase, m42
ETK61_RS15805	COG3326	Membrane
ETK61_RS15810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ETK61_RS15815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ETK61_RS15820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ETK61_RS15830	COG1346	cytolysis
ETK61_RS15835	COG1380	Effector of murein hydrolase LrgA
ETK61_RS15840	COG3279	Response regulator of the LytR AlgR family
ETK61_RS15845	COG3275	phosphorelay sensor kinase activity
ETK61_RS15850	COG1011	Hydrolase
ETK61_RS15855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ETK61_RS15865	COG0398	Pfam SNARE associated Golgi protein
ETK61_RS15870	COG1484	DNA-dependent DNA replication
ETK61_RS15875	COG3611	Membrane attachment protein
ETK61_RS15880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ETK61_RS15885	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ETK61_RS15890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ETK61_RS15895	COG1733	regulation of RNA biosynthetic process
ETK61_RS15900	COG2814	Major facilitator Superfamily
ETK61_RS15905	COG0656	L-ascorbic acid biosynthetic process
ETK61_RS15910	COG0237	dephospho-CoA kinase activity
ETK61_RS15915	COG1971	Probably functions as a manganese efflux pump
ETK61_RS15920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ETK61_RS15925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK61_RS15925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ETK61_RS15930	COG5002	protein histidine kinase activity
ETK61_RS15935	COG0745	RESPONSE REGULATOR receiver
ETK61_RS15940	COG0039	L-malate dehydrogenase activity
ETK61_RS15945	COG0538	isocitrate dehydrogenase activity
ETK61_RS15950	COG0372	Belongs to the citrate synthase family
ETK61_RS15955	COG2707	UPF0756 membrane protein
ETK61_RS15960	COG0628	permease
ETK61_RS15965	COG3030	protein affecting phage T7 exclusion by the F plasmid
ETK61_RS15970	COG0469	pyruvate kinase activity
ETK61_RS15975	COG0205	6-phosphofructokinase activity
ETK61_RS15980	COG0825	malonyl-CoA metabolic process
ETK61_RS15985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ETK61_RS15990	COG0281	malic enzyme
ETK61_RS15995	COG0587	DNA-directed DNA polymerase activity
ETK61_RS16015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ETK61_RS16025	COG4109	DRTGG domain
ETK61_RS16030	COG0730	response to heat
ETK61_RS16035	COG1473	amidohydrolase
ETK61_RS16040	COG0196	riboflavin kinase activity
ETK61_RS16045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS16050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ETK61_RS16055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS16060	COG1126	abc transporter atp-binding protein
ETK61_RS16065	COG0765	amino acid transport
ETK61_RS16070	COG0765	amino acid transport
ETK61_RS16075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS16080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS16085	COG0454	-acetyltransferase
ETK61_RS16090	COG0583	DNA-binding transcription factor activity
ETK61_RS16095	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ETK61_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS16110	COG0165	Argininosuccinate lyase
ETK61_RS16115	COG0137	argininosuccinate synthase activity
ETK61_RS16120	COG0521	Mo-molybdopterin cofactor biosynthetic process
ETK61_RS16125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ETK61_RS16135	COG0827	DNA restriction-modification system
ETK61_RS16140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ETK61_RS16145	COG3874	Sporulation protein YtfJ
ETK61_RS16155	COG1714	RDD family
ETK61_RS16160	COG0616	signal peptide processing
ETK61_RS16165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ETK61_RS16170	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ETK61_RS16175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETK61_RS16185	COG0301	tRNA thio-modification
ETK61_RS16190	COG1104	cysteine desulfurase activity
ETK61_RS16195	COG1114	Component of the transport system for branched-chain amino acids
ETK61_RS16200	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ETK61_RS16205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ETK61_RS16210	COG1309	transcriptional regulator
ETK61_RS16215	COG1956	GAF domain-containing protein
ETK61_RS16220	COG2199	diguanylate cyclase activity
ETK61_RS16220	COG2203	Gaf domain
ETK61_RS16230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ETK61_RS16235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ETK61_RS16240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ETK61_RS16245	COG0454	-acetyltransferase
ETK61_RS16250	COG0517	IMP dehydrogenase activity
ETK61_RS16255	COG0123	including yeast histone deacetylase and acetoin utilization protein
ETK61_RS16260	COG1360	Flagellar Motor Protein
ETK61_RS16265	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ETK61_RS16270	COG1609	Transcriptional regulator
ETK61_RS16275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ETK61_RS16275	COG1605	Chorismate mutase
ETK61_RS16280	COG3118	belongs to the thioredoxin family
ETK61_RS16285	COG4980	gas vesicle protein
ETK61_RS16290	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ETK61_RS16295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ETK61_RS16300	COG1674	ftsk spoiiie
ETK61_RS16305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS16310	COG4848	Belongs to the UPF0354 family
ETK61_RS16315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS16330	COG1363	Peptidase, m42
ETK61_RS16335	COG5584	Small secreted protein
ETK61_RS16340	COG0281	malic enzyme
ETK61_RS16345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS16350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ETK61_RS16360	COG0510	thiamine kinase activity
ETK61_RS16365	COG1523	belongs to the glycosyl hydrolase 13 family
ETK61_RS16370	COG1597	lipid kinase activity
ETK61_RS16380	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ETK61_RS16385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ETK61_RS16390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK61_RS16395	COG2252	PERMEase
ETK61_RS16400	COG4473	ABC transporter
ETK61_RS16405	COG1131	(ABC) transporter
ETK61_RS16410	COG1349	DNA-binding transcription factor activity
ETK61_RS16420	COG1187	pseudouridine synthase activity
ETK61_RS16425	COG2244	polysaccharide biosynthetic process
ETK61_RS16430	COG2081	HI0933 family
ETK61_RS16435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ETK61_RS16445	COG5578	integral membrane protein
ETK61_RS16450	COG0673	inositol 2-dehydrogenase activity
ETK61_RS16455	COG1653	transport
ETK61_RS16460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ETK61_RS16465	COG4209	transmembrane transport
ETK61_RS16475	COG1653	transport
ETK61_RS16480	COG0395	ABC-type sugar transport system, permease component
ETK61_RS16485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK61_RS16490	COG2124	cytochrome p450
ETK61_RS16495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ETK61_RS16505	COG0156	8-amino-7-oxononanoate synthase activity
ETK61_RS16510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK61_RS16520	COG1073	alpha beta
ETK61_RS16525	COG1609	Transcriptional regulator
ETK61_RS16530	COG1653	transport
ETK61_RS16535	COG1175	transmembrane transport
ETK61_RS16540	COG0395	ABC-type sugar transport system, permease component
ETK61_RS16545	COG1486	melibiose metabolic process
ETK61_RS16550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ETK61_RS16555	COG0495	leucyl-tRNA aminoacylation
ETK61_RS16565	COG1366	Belongs to the anti-sigma-factor antagonist family
ETK61_RS16565	COG2202	Pas domain
ETK61_RS16570	COG2814	Major facilitator Superfamily
ETK61_RS16585	COG3328	transposase activity
ETK61_RS16595	COG1136	(ABC) transporter
ETK61_RS16600	COG2205	protein histidine kinase activity
ETK61_RS16605	COG0745	RESPONSE REGULATOR receiver
ETK61_RS16610	COG0577	efflux transmembrane transporter activity
ETK61_RS16615	COG1136	(ABC) transporter
ETK61_RS16630	COG1131	(ABC) transporter
ETK61_RS16635	COG1725	Transcriptional regulator
ETK61_RS16650	COG1242	4 iron, 4 sulfur cluster binding
ETK61_RS16655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ETK61_RS16665	COG2267	carboxylic ester hydrolase activity
ETK61_RS16670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ETK61_RS16675	COG1113	amino acid transport
ETK61_RS16680	COG0367	asparagine synthase
ETK61_RS16685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ETK61_RS16690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ETK61_RS16700	COG1506	peptidase
ETK61_RS16705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ETK61_RS16710	COG1116	anion transmembrane transporter activity
ETK61_RS16715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ETK61_RS16720	COG0494	nUDIX hydrolase
ETK61_RS16725	COG4824	toxin secretion phage lysis holin
ETK61_RS16730	COG0783	Belongs to the Dps family
ETK61_RS16745	COG1854	S-ribosylhomocysteine lyase activity
ETK61_RS16750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ETK61_RS16755	COG0288	reversible hydration of carbon dioxide
ETK61_RS16760	COG0254	rRNA binding
ETK61_RS16765	COG1271	oxidase subunit
ETK61_RS16770	COG1294	oxidase, subunit
ETK61_RS16780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETK61_RS16785	COG1321	iron dependent repressor
ETK61_RS16785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ETK61_RS16790	COG1121	(ABC) transporter
ETK61_RS16795	COG0803	Belongs to the bacterial solute-binding protein 9 family
ETK61_RS16805	COG4948	Mandelate Racemase Muconate Lactonizing
ETK61_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
ETK61_RS16815	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ETK61_RS16820	COG0596	Alpha beta hydrolase
ETK61_RS16825	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ETK61_RS16830	COG1169	isochorismate synthase
ETK61_RS16840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ETK61_RS16845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ETK61_RS16850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ETK61_RS16855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ETK61_RS16860	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS16870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK61_RS16875	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS16880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK61_RS16885	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ETK61_RS16890	COG0058	SHG alpha-glucan phosphorylase activity
ETK61_RS16895	COG0297	glycogen (starch) synthase activity
ETK61_RS16900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ETK61_RS16905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ETK61_RS16910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ETK61_RS17035	COG3859	Proton-coupled thiamine transporter YuaJ
ETK61_RS17040	COG1247	-acetyltransferase
ETK61_RS17045	COG2268	Band 7 protein
ETK61_RS17050	COG1585	Membrane protein implicated in regulation of membrane protease activity
ETK61_RS17055	COG2318	DinB family
ETK61_RS17065	COG1454	alcohol dehydrogenase
ETK61_RS17070	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS17075	COG1510	regulation of RNA biosynthetic process
ETK61_RS17090	COG0569	domain protein
ETK61_RS17095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ETK61_RS17100	COG4682	membrane
ETK61_RS17105	COG1705	Flagellar rod assembly protein muramidase FlgJ
ETK61_RS17110	COG0477	Major facilitator Superfamily
ETK61_RS17115	COG5553	Cysteine dioxygenase type I
ETK61_RS17125	COG1968	undecaprenyl-diphosphatase activity
ETK61_RS17130	COG0628	permease
ETK61_RS17135	COG0673	inositol 2-dehydrogenase activity
ETK61_RS17140	COG4806	L-rhamnose isomerase
ETK61_RS17145	COG3254	rhamnose metabolic process
ETK61_RS17150	COG1070	Carbohydrate kinase
ETK61_RS17155	COG1349	DNA-binding transcription factor activity
ETK61_RS17160	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS17160	COG3347	Dehydrogenase
ETK61_RS17170	COG0840	transmembrane signaling receptor activity
ETK61_RS17175	COG0840	transmembrane signaling receptor activity
ETK61_RS17185	COG0840	transmembrane signaling receptor activity
ETK61_RS17200	COG0432	Pfam Uncharacterised protein family UPF0047
ETK61_RS17210	COG0366	Alpha amylase catalytic
ETK61_RS17215	COG1253	flavin adenine dinucleotide binding
ETK61_RS17220	COG2738	Putative neutral zinc metallopeptidase
ETK61_RS17235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ETK61_RS17250	COG0166	Belongs to the GPI family
ETK61_RS17255	COG1979	alcohol dehydrogenase
ETK61_RS17260	COG1979	alcohol dehydrogenase
ETK61_RS17265	COG2155	Conserved Protein
ETK61_RS17270	COG1098	S1 RNA binding domain
ETK61_RS17275	COG0436	Aminotransferase
ETK61_RS17280	COG1522	sequence-specific DNA binding
ETK61_RS17285	COG2267	carboxylic ester hydrolase activity
ETK61_RS17295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ETK61_RS17300	COG2205	protein histidine kinase activity
ETK61_RS17310	COG5018	Exonuclease
ETK61_RS17320	COG2814	Major facilitator Superfamily
ETK61_RS17325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK61_RS17330	COG3011	Protein conserved in bacteria
ETK61_RS17340	COG3290	protein histidine kinase activity
ETK61_RS17345	COG4565	transcriptional regulatory protein
ETK61_RS17350	COG1744	ABC transporter substrate-binding protein PnrA-like
ETK61_RS17355	COG3845	ABC transporter
ETK61_RS17360	COG4603	Belongs to the binding-protein-dependent transport system permease family
ETK61_RS17365	COG1079	Belongs to the binding-protein-dependent transport system permease family
ETK61_RS17370	COG3493	citrate carrier protein
ETK61_RS17380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ETK61_RS17380	COG2111	Na H antiporter
ETK61_RS17385	COG2111	Na H antiporter
ETK61_RS17390	COG1006	Multisubunit Na H antiporter MnhC subunit
ETK61_RS17395	COG0651	ATP synthesis coupled electron transport
ETK61_RS17400	COG1863	multisubunit Na H antiporter MnhE subunit
ETK61_RS17405	COG2212	antiporter activity
ETK61_RS17410	COG1320	monovalent cation:proton antiporter activity
ETK61_RS17415	COG2050	protein possibly involved in aromatic compounds catabolism
ETK61_RS17420	COG2197	response regulator
ETK61_RS17425	COG4585	Histidine kinase
ETK61_RS17435	COG0142	geranyltranstransferase activity
ETK61_RS17455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ETK61_RS17460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ETK61_RS17465	COG1335	isochorismatase
ETK61_RS17470	COG5506	Protein of unknown function (DUF1694)
ETK61_RS17485	COG0628	permease
ETK61_RS17500	COG1418	mRNA catabolic process
ETK61_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS17515	COG1511	domain protein
ETK61_RS17520	COG0433	COG0433 Predicted ATPase
ETK61_RS17520	COG1674	ftsk spoiiie
ETK61_RS17525	COG4499	WXG100 protein secretion system (Wss), protein YukC
ETK61_RS17530	COG5417	Belongs to the EsaB family
ETK61_RS17535	COG4842	Belongs to the WXG100 family
ETK61_RS17545	COG2508	Transcriptional regulator
ETK61_RS17545	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ETK61_RS17550	COG0686	Belongs to the AlaDH PNT family
ETK61_RS17555	COG5634	Uncharacterized conserved protein (DUF2278)
ETK61_RS17560	COG3251	PFAM MbtH domain protein
ETK61_RS17565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS17570	COG3433	isochorismatase activity
ETK61_RS17570	COG1535	isochorismatase
ETK61_RS17575	COG1021	2,3-dihydroxybenzoate-AMP ligase
ETK61_RS17580	COG1169	isochorismate synthase
ETK61_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS17590	COG2819	hydrolase of the alpha beta superfamily
ETK61_RS17595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ETK61_RS17600	COG1268	BioY protein
ETK61_RS17605	COG2056	Na+-H+ antiporter family
ETK61_RS17610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ETK61_RS17615	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ETK61_RS17620	COG3584	3D domain protein
ETK61_RS17635	COG1252	NADH dehydrogenase
ETK61_RS17640	COG0492	ferredoxin-NADP+ reductase activity
ETK61_RS17650	COG0516	GMP reductase activity
ETK61_RS17655	COG2808	Putative FMN-binding domain
ETK61_RS17660	COG0456	acetyltransferase
ETK61_RS17665	COG0316	Belongs to the HesB IscA family
ETK61_RS17670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ETK61_RS17675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK61_RS17680	COG4844	belongs to the
ETK61_RS17685	COG1252	NADH dehydrogenase
ETK61_RS17690	COG4837	Protein of unknown function (DUF1462)
ETK61_RS17695	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ETK61_RS17700	COG0823	Involved in the tonB-independent uptake of proteins
ETK61_RS17700	COG1506	peptidase
ETK61_RS17700	COG4946	Tricorn protease homolog
ETK61_RS17705	COG0083	homoserine kinase activity
ETK61_RS17710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ETK61_RS17715	COG0460	homoserine dehydrogenase
ETK61_RS17720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ETK61_RS17725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ETK61_RS17730	COG0647	UMP catabolic process
ETK61_RS17735	COG2445	Protein of unknown function DUF86
ETK61_RS17740	COG4470	Protein conserved in bacteria
ETK61_RS17750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ETK61_RS17755	COG0739	heme binding
ETK61_RS17765	COG3377	Domain of unknown function (DUF1805)
ETK61_RS17770	COG0737	Belongs to the 5'-nucleotidase family
ETK61_RS17775	COG0730	response to heat
ETK61_RS17780	COG1801	Protein of unknown function DUF72
ETK61_RS17790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ETK61_RS17795	COG2508	Transcriptional regulator
ETK61_RS17800	COG2233	PERMEase
ETK61_RS17805	COG2233	PERMEase
ETK61_RS17810	COG3648	Uricase
ETK61_RS17810	COG3195	allantoin biosynthetic process
ETK61_RS17815	COG2351	hydroxyisourate hydrolase activity
ETK61_RS17825	COG2080	2 iron, 2 sulfur cluster binding
ETK61_RS17830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ETK61_RS17835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ETK61_RS17840	COG2068	MobA-Related Protein
ETK61_RS17845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ETK61_RS17850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ETK61_RS17855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK61_RS17865	COG2356	endonuclease I
ETK61_RS17880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ETK61_RS17890	COG0072	phenylalanine-tRNA ligase activity
ETK61_RS17890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ETK61_RS17910	COG3842	ATPase activity
ETK61_RS17915	COG2188	Transcriptional regulator
ETK61_RS17930	COG1653	transport
ETK61_RS17935	COG2222	sugar isomerase
ETK61_RS17940	COG0322	excinuclease ABC activity
ETK61_RS17945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ETK61_RS17965	COG3328	transposase activity
ETK61_RS17980	COG0719	Fe-S assembly protein
ETK61_RS17985	COG0822	iron-sulfur transferase activity
ETK61_RS17990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ETK61_RS17995	COG0719	Fe-S assembly protein
ETK61_RS18000	COG0396	ATPase activity
ETK61_RS18020	COG1464	Belongs to the NlpA lipoprotein family
ETK61_RS18025	COG2011	ABC-type metal ion transport system permease component
ETK61_RS18030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ETK61_RS18040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ETK61_RS18045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ETK61_RS18055	COG0509	glycine decarboxylation via glycine cleavage system
ETK61_RS18060	COG1393	Belongs to the ArsC family
ETK61_RS18065	COG1960	acyl-CoA dehydrogenase activity
ETK61_RS18070	COG0183	Belongs to the thiolase family
ETK61_RS18075	COG1024	Enoyl-CoA hydratase
ETK61_RS18075	COG1250	3-hydroxyacyl-CoA dehydrogenase
ETK61_RS18085	COG0506	proline dehydrogenase activity
ETK61_RS18095	COG5577	PFAM Coat F domain
ETK61_RS18100	COG1846	Transcriptional regulator
ETK61_RS18105	COG0477	Major facilitator Superfamily
ETK61_RS18110	COG1942	4-Oxalocrotonate Tautomerase
ETK61_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS18120	COG0583	DNA-binding transcription factor activity
ETK61_RS18130	COG1120	ATPase activity
ETK61_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS18150	COG0783	Belongs to the Dps family
ETK61_RS18155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK61_RS18160	COG0745	RESPONSE REGULATOR receiver
ETK61_RS18165	COG2205	protein histidine kinase activity
ETK61_RS18165	COG2770	Histidine kinase
ETK61_RS18175	COG1309	transcriptional regulator
ETK61_RS18180	COG0114	fumarate hydratase activity
ETK61_RS18190	COG0697	spore germination
ETK61_RS18195	COG0814	amino acid
ETK61_RS18205	COG2197	response regulator
ETK61_RS18210	COG4585	Histidine kinase
ETK61_RS18215	COG4758	membrane
ETK61_RS18220	COG3595	metallopeptidase activity
ETK61_RS18225	COG1842	Phage shock protein A
ETK61_RS18230	COG4758	membrane
ETK61_RS18235	COG2814	Major facilitator Superfamily
ETK61_RS18240	COG2096	Adenosyltransferase
ETK61_RS18245	COG1120	ATPase activity
ETK61_RS18250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS18255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS18265	COG3386	PFAM SMP-30 Gluconolaconase
ETK61_RS18270	COG2205	protein histidine kinase activity
ETK61_RS18275	COG0745	RESPONSE REGULATOR receiver
ETK61_RS18285	COG1191	sigma factor activity
ETK61_RS18295	COG2140	Oxalate decarboxylase
ETK61_RS18305	COG0577	efflux transmembrane transporter activity
ETK61_RS18310	COG1136	(ABC) transporter
ETK61_RS18315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ETK61_RS18320	COG1120	ATPase activity
ETK61_RS18325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS18330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ETK61_RS18335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS18340	COG0531	amino acid
ETK61_RS18355	COG1988	membrane-bound metal-dependent
ETK61_RS18360	COG1368	sulfuric ester hydrolase activity
ETK61_RS18365	COG1910	domain protein
ETK61_RS18370	COG0725	ABC transporter, periplasmic molybdate-binding protein
ETK61_RS18375	COG4149	molybdate abc transporter
ETK61_RS18380	COG0656	L-ascorbic acid biosynthetic process
ETK61_RS18390	COG0025	NhaP-type Na H and K H
ETK61_RS18395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ETK61_RS18400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ETK61_RS18405	COG3973	AAA domain
ETK61_RS18410	COG2860	membrane
ETK61_RS18415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ETK61_RS18420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ETK61_RS18425	COG2217	Heavy metal translocating P-type atpase
ETK61_RS18430	COG2217	Heavy metal translocating P-type atpase
ETK61_RS18435	COG2608	mercury ion transmembrane transporter activity
ETK61_RS18440	COG1937	Protein conserved in bacteria
ETK61_RS18445	COG0673	inositol 2-dehydrogenase activity
ETK61_RS18450	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ETK61_RS18465	COG2076	Multidrug Resistance protein
ETK61_RS18470	COG1309	transcriptional regulator
ETK61_RS18485	COG5444	nuclease activity
ETK61_RS18500	COG1388	LysM domain
ETK61_RS18500	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS18500	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS18505	COG4824	toxin secretion phage lysis holin
ETK61_RS18535	COG3942	CHAP domain
ETK61_RS18535	COG1705	Flagellar rod assembly protein muramidase FlgJ
ETK61_RS18645	COG0582	viral genome integration into host DNA
ETK61_RS18725	COG0582	viral genome integration into host DNA
ETK61_RS18735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ETK61_RS18740	COG0557	exoribonuclease II activity
ETK61_RS18745	COG1647	Serine aminopeptidase, S33
ETK61_RS18750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ETK61_RS18755	COG0596	Alpha beta hydrolase
ETK61_RS18760	COG1476	TRANSCRIPTIONal
ETK61_RS18765	COG1396	sequence-specific DNA binding
ETK61_RS18770	COG1396	sequence-specific DNA binding
ETK61_RS18775	COG1733	regulation of RNA biosynthetic process
ETK61_RS18785	COG1174	glycine betaine transport
ETK61_RS18790	COG1732	Glycine betaine
ETK61_RS18795	COG1174	glycine betaine transport
ETK61_RS18800	COG1125	glycine betaine transport
ETK61_RS18800	COG0517	IMP dehydrogenase activity
ETK61_RS18805	COG1510	regulation of RNA biosynthetic process
ETK61_RS18825	COG5658	integral membrane protein
ETK61_RS18830	COG0640	Transcriptional regulator
ETK61_RS18835	COG1174	glycine betaine transport
ETK61_RS18840	COG1732	Glycine betaine
ETK61_RS18845	COG1174	glycine betaine transport
ETK61_RS18850	COG0517	IMP dehydrogenase activity
ETK61_RS18850	COG1125	glycine betaine transport
ETK61_RS18855	COG1510	regulation of RNA biosynthetic process
ETK61_RS18860	COG2095	MarC family integral membrane protein
ETK61_RS18870	COG3064	Membrane
ETK61_RS18875	COG4640	response to antibiotic
ETK61_RS18880	COG0456	acetyltransferase
ETK61_RS18885	COG0148	phosphopyruvate hydratase activity
ETK61_RS18890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ETK61_RS18895	COG0149	triose-phosphate isomerase activity
ETK61_RS18900	COG0126	phosphoglycerate kinase activity
ETK61_RS18905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ETK61_RS18910	COG2390	Transcriptional regulator
ETK61_RS18915	COG2814	Major facilitator Superfamily
ETK61_RS18920	COG1609	Transcriptional regulator
ETK61_RS18925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS18935	COG0583	DNA-binding transcription factor activity
ETK61_RS18940	COG0697	spore germination
ETK61_RS18945	COG1113	amino acid transport
ETK61_RS18950	COG3858	chitin binding
ETK61_RS18955	COG1556	Lactate utilization protein
ETK61_RS18960	COG1139	Iron-sulfur cluster binding protein
ETK61_RS18965	COG0247	lactate metabolic process
ETK61_RS18970	COG2197	response regulator
ETK61_RS18975	COG4585	Histidine kinase
ETK61_RS18980	COG0842	Transport permease protein
ETK61_RS18985	COG1131	(ABC) transporter
ETK61_RS18990	COG0596	Alpha beta hydrolase
ETK61_RS18995	COG2208	phosphoserine phosphatase activity
ETK61_RS19000	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ETK61_RS19005	COG1874	Beta-galactosidase
ETK61_RS19010	COG3833	ABC-type maltose transport systems, permease component
ETK61_RS19015	COG1175	transmembrane transport
ETK61_RS19020	COG2182	Extracellular solute-binding protein
ETK61_RS19025	COG1609	Transcriptional regulator
ETK61_RS19030	COG2186	Transcriptional regulator
ETK61_RS19035	COG1620	l-lactate permease
ETK61_RS19040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ETK61_RS19050	COG5039	Polysaccharide pyruvyl transferase
ETK61_RS19055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK61_RS19060	COG0110	maltose O-acetyltransferase activity
ETK61_RS19065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ETK61_RS19070	COG2244	polysaccharide biosynthetic process
ETK61_RS19075	COG1216	Glycosyl transferase, family 2
ETK61_RS19080	COG5039	Polysaccharide pyruvyl transferase
ETK61_RS19085	COG1216	Glycosyl transferase, family 2
ETK61_RS19095	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS19100	COG1215	transferase activity, transferring glycosyl groups
ETK61_RS19105	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS19110	COG1086	Polysaccharide biosynthesis protein
ETK61_RS19115	COG0489	protein tyrosine kinase activity
ETK61_RS19120	COG3944	biosynthesis protein
ETK61_RS19125	COG1396	sequence-specific DNA binding
ETK61_RS19130	COG2272	Belongs to the type-B carboxylesterase lipase family
ETK61_RS19140	COG3479	Phenolic acid decarboxylase
ETK61_RS19150	COG1794	racemase activity, acting on amino acids and derivatives
ETK61_RS19155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ETK61_RS19160	COG1621	beta-fructofuranosidase activity
ETK61_RS19165	COG1621	beta-fructofuranosidase activity
ETK61_RS19170	COG0531	amino acid
ETK61_RS19175	COG1309	transcriptional regulator
ETK61_RS19180	COG2076	Multidrug Resistance protein
ETK61_RS19185	COG2076	Multidrug Resistance protein
ETK61_RS19200	COG0740	serine-type endopeptidase activity
ETK61_RS19205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ETK61_RS19210	COG0366	Alpha amylase catalytic
ETK61_RS19215	COG1554	hydrolase, family 65, central catalytic
ETK61_RS19220	COG5521	maltodextrose utilization protein MalA
ETK61_RS19225	COG3833	ABC-type maltose transport systems, permease component
ETK61_RS19230	COG1175	transmembrane transport
ETK61_RS19235	COG2182	Extracellular solute-binding protein
ETK61_RS19240	COG0366	Alpha amylase catalytic
ETK61_RS19245	COG1609	Transcriptional regulator
ETK61_RS19250	COG1611	Belongs to the LOG family
ETK61_RS19260	COG0659	secondary active sulfate transmembrane transporter activity
ETK61_RS19265	COG0288	reversible hydration of carbon dioxide
ETK61_RS19270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ETK61_RS19275	COG0577	efflux transmembrane transporter activity
ETK61_RS19280	COG1136	(ABC) transporter
ETK61_RS19285	COG5002	protein histidine kinase activity
ETK61_RS19290	COG0745	RESPONSE REGULATOR receiver
ETK61_RS19300	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ETK61_RS19305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS19310	COG1481	regulation of sporulation
ETK61_RS19315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ETK61_RS19320	COG1660	Displays ATPase and GTPase activities
ETK61_RS19325	COG1051	belongs to the nudix hydrolase family
ETK61_RS19330	COG0492	ferredoxin-NADP+ reductase activity
ETK61_RS19335	COG0791	NLP P60 protein
ETK61_RS19335	COG3883	PFAM NLP P60 protein
ETK61_RS19340	COG0457	Tetratricopeptide repeat
ETK61_RS19345	COG1132	(ABC) transporter
ETK61_RS19365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ETK61_RS19365	COG0140	phosphoribosyl-ATP diphosphatase activity
ETK61_RS19370	COG0107	imidazoleglycerol-phosphate synthase activity
ETK61_RS19375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ETK61_RS19380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ETK61_RS19385	COG0131	Imidazoleglycerol-phosphate dehydratase
ETK61_RS19390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ETK61_RS19395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ETK61_RS19400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ETK61_RS19405	COG4990	cell redox homeostasis
ETK61_RS19410	COG5297	Belongs to the glycosyl hydrolase family 6
ETK61_RS19415	COG0110	maltose O-acetyltransferase activity
ETK61_RS19420	COG0546	phosphoglycolate phosphatase activity
ETK61_RS19425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ETK61_RS19430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ETK61_RS19435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ETK61_RS19440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ETK61_RS19445	COG0363	glucosamine-6-phosphate deaminase activity
ETK61_RS19455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ETK61_RS19460	COG1950	PFAM Membrane protein of
ETK61_RS19465	COG1983	PspC domain protein
ETK61_RS19470	COG3595	metallopeptidase activity
ETK61_RS19485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETK61_RS19490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ETK61_RS19495	COG0556	nucleotide-excision repair
ETK61_RS19500	COG4897	Protein conserved in bacteria
ETK61_RS19505	COG0574	Belongs to the PEP-utilizing enzyme family
ETK61_RS19505	COG3848	Pyruvate phosphate dikinase
ETK61_RS19510	COG1309	transcriptional regulator
ETK61_RS19515	COG2814	Major facilitator Superfamily
ETK61_RS19520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK61_RS19530	COG0793	Belongs to the peptidase S41A family
ETK61_RS19530	COG3409	Peptidoglycan-binding domain 1 protein
ETK61_RS19535	COG2177	Part of the ABC transporter FtsEX involved in
ETK61_RS19540	COG2884	Cell division ATP-binding protein ftsE
ETK61_RS19545	COG2010	Cytochrome c
ETK61_RS19550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS19560	COG0653	protein targeting
ETK61_RS19565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ETK61_RS19580	COG1516	flagellar protein fliS
ETK61_RS19585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ETK61_RS19590	COG1334	flagellar protein FlaG
ETK61_RS19595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETK61_RS19600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ETK61_RS19605	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ETK61_RS19615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ETK61_RS19620	COG4786	Flagellar basal body rod
ETK61_RS19620	COG1256	bacterial-type flagellum assembly
ETK61_RS19625	COG3418	PFAM FlgN family protein
ETK61_RS19630	COG2747	anti-sigma28 factor FlgM
ETK61_RS19640	COG1040	competence protein
ETK61_RS19650	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ETK61_RS19655	COG1307	EDD domain protein, DegV family
ETK61_RS19660	COG2197	response regulator
ETK61_RS19665	COG4585	Histidine kinase
ETK61_RS19670	COG1739	Uncharacterized protein family UPF0029
ETK61_RS19675	COG1316	TRANSCRIPTIONal
ETK61_RS19680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ETK61_RS19685	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS19690	COG1215	transferase activity, transferring glycosyl groups
ETK61_RS19695	COG3206	protein involved in exopolysaccharide biosynthesis
ETK61_RS19700	COG3307	-O-antigen
ETK61_RS19705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ETK61_RS19710	COG0297	glycogen (starch) synthase activity
ETK61_RS19710	COG0438	transferase activity, transferring glycosyl groups
ETK61_RS19715	COG2244	polysaccharide biosynthetic process
ETK61_RS19730	COG0860	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS19730	COG2247	cell wall binding repeat
ETK61_RS19735	COG2247	cell wall binding repeat
ETK61_RS19735	COG2385	sporulation resulting in formation of a cellular spore
ETK61_RS19745	COG1316	TRANSCRIPTIONal
ETK61_RS19750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ETK61_RS19770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ETK61_RS19775	COG1134	teichoic acid transport
ETK61_RS19780	COG1682	transport, permease protein
ETK61_RS19795	COG1215	transferase activity, transferring glycosyl groups
ETK61_RS19795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ETK61_RS19800	COG0463	Glycosyl transferase, family 2
ETK61_RS19845	COG4193	domain, Protein
ETK61_RS19850	COG1482	cell wall glycoprotein biosynthetic process
ETK61_RS19855	COG0697	spore germination
ETK61_RS19860	COG0814	amino acid
ETK61_RS19870	COG2814	Major facilitator Superfamily
ETK61_RS19875	COG1316	TRANSCRIPTIONal
ETK61_RS19880	COG0561	phosphatase activity
ETK61_RS19890	COG0791	NLP P60 protein
ETK61_RS19900	COG2843	Capsule synthesis protein
ETK61_RS19910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ETK61_RS19915	COG1609	Transcriptional regulator
ETK61_RS19920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK61_RS19925	COG1869	D-ribose catabolic process
ETK61_RS19930	COG1129	ABC transporter
ETK61_RS19935	COG1172	Belongs to the binding-protein-dependent transport system permease family
ETK61_RS19940	COG1879	ABC-type sugar transport system periplasmic component
ETK61_RS19945	COG3103	Sh3 type 3 domain protein
ETK61_RS19955	COG2249	NAD(P)H dehydrogenase (quinone) activity
ETK61_RS19965	COG3527	Alpha-acetolactate decarboxylase
ETK61_RS19970	COG0028	Belongs to the TPP enzyme family
ETK61_RS19975	COG0583	DNA-binding transcription factor activity
ETK61_RS19995	COG5337	Spore coat protein CotH
ETK61_RS20005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ETK61_RS20015	COG0405	Gamma-glutamyltransferase
ETK61_RS20020	COG1522	sequence-specific DNA binding
ETK61_RS20025	COG2059	Chromate
ETK61_RS20030	COG2059	Chromate
ETK61_RS20040	COG0655	NAD(P)H dehydrogenase (quinone) activity
ETK61_RS20045	COG0583	DNA-binding transcription factor activity
ETK61_RS20050	COG1515	deoxyribonuclease V activity
ETK61_RS20075	COG5444	nuclease activity
ETK61_RS20090	COG3878	Protein conserved in bacteria
ETK61_RS20100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ETK61_RS20105	COG4464	protein tyrosine phosphatase activity
ETK61_RS20110	COG0489	protein tyrosine kinase activity
ETK61_RS20115	COG3944	biosynthesis protein
ETK61_RS20125	COG4715	Zinc finger, swim domain protein
ETK61_RS20130	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ETK61_RS20135	COG0561	phosphatase activity
ETK61_RS20140	COG1349	DNA-binding transcription factor activity
ETK61_RS20145	COG0629	single-stranded DNA binding
ETK61_RS20165	COG3328	transposase activity
ETK61_RS20170	COG3764	Sortase (surface protein transpeptidase)
ETK61_RS20180	COG2972	Histidine kinase
ETK61_RS20180	COG0745	RESPONSE REGULATOR receiver
ETK61_RS20185	COG1970	mechanosensitive ion channel activity
ETK61_RS20190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ETK61_RS20195	COG0457	Tetratricopeptide repeat
ETK61_RS20200	COG4786	Flagellar basal body rod
ETK61_RS20205	COG4786	Flagellar basal body rod
ETK61_RS20210	COG1077	Cell shape determining protein MreB Mrl
ETK61_RS20215	COG1609	Transcriptional regulator
ETK61_RS20225	COG1846	Transcriptional regulator
ETK61_RS20230	COG2814	Major facilitator Superfamily
ETK61_RS20235	COG3420	alginic acid biosynthetic process
ETK61_RS20240	COG1953	Uracil, thiamine, allantoin
ETK61_RS20245	COG0477	Major facilitator Superfamily
ETK61_RS20250	COG1335	isochorismatase
ETK61_RS20260	COG0004	ammonium transporteR
ETK61_RS20265	COG0347	Belongs to the P(II) protein family
ETK61_RS20270	COG0671	phosphoesterase, PA-phosphatase related
ETK61_RS20300	COG0739	heme binding
ETK61_RS20305	COG1247	-acetyltransferase
ETK61_RS20325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK61_RS20330	COG0789	Transcriptional regulator
ETK61_RS20340	COG2910	NAD(P)H-binding
ETK61_RS20345	COG1959	2 iron, 2 sulfur cluster binding
ETK61_RS20350	COG0804	urea catabolic process
ETK61_RS20355	COG0832	Belongs to the urease beta subunit family
ETK61_RS20360	COG0831	urea catabolic process
ETK61_RS20375	COG3237	CsbD-like
ETK61_RS20380	COG1994	Peptidase M50
ETK61_RS20385	COG0457	Tetratricopeptide repeat
ETK61_RS20390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ETK61_RS20395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ETK61_RS20405	COG2304	oxidoreductase activity
ETK61_RS20415	COG2304	oxidoreductase activity
ETK61_RS20420	COG2385	sporulation resulting in formation of a cellular spore
ETK61_RS20425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ETK61_RS20435	COG4836	Membrane
ETK61_RS20445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ETK61_RS20450	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ETK61_RS20455	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ETK61_RS20460	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ETK61_RS20465	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ETK61_RS20470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ETK61_RS20480	COG0356	it plays a direct role in the translocation of protons across the membrane
ETK61_RS20490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ETK61_RS20495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ETK61_RS20500	COG4475	Protein of unknown function (DUF436)
ETK61_RS20505	COG0698	ribose 5-phosphate isomerase
ETK61_RS20510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ETK61_RS20515	COG1971	Probably functions as a manganese efflux pump
ETK61_RS20520	COG0009	L-threonylcarbamoyladenylate synthase
ETK61_RS20525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ETK61_RS20545	COG2890	protein-(glutamine-N5) methyltransferase activity
ETK61_RS20550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ETK61_RS20555	COG0346	lactoylglutathione lyase activity
ETK61_RS20560	COG0789	Transcriptional regulator
ETK61_RS20565	COG0679	Auxin Efflux Carrier
ETK61_RS20570	COG0281	malic enzyme
ETK61_RS20575	COG1435	thymidine kinase activity
ETK61_RS20585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ETK61_RS20595	COG1494	fructose-1,6-bisphosphatase
ETK61_RS20600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ETK61_RS20605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ETK61_RS20610	COG0191	fructose-bisphosphate aldolase activity
ETK61_RS20615	COG2204	response regulator
ETK61_RS20620	COG4821	SIS domain
ETK61_RS20625	COG0504	CTP synthase activity
ETK61_RS20630	COG3343	RNA polymerase activity
ETK61_RS20635	COG1960	acyl-CoA dehydrogenase activity
ETK61_RS20640	COG0247	lactate metabolic process
ETK61_RS20640	COG2181	nitrate reductase activity
ETK61_RS20645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK61_RS20650	COG4294	response to UV
ETK61_RS20660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ETK61_RS20665	COG1132	(ABC) transporter
ETK61_RS20670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ETK61_RS20680	COG2181	nitrate reductase activity
ETK61_RS20685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ETK61_RS20690	COG1140	nitrate reductase beta subunit
ETK61_RS20695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ETK61_RS20705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ETK61_RS20715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ETK61_RS20720	COG2223	nitrite transmembrane transporter activity
ETK61_RS20725	COG0018	arginyl-trna synthetase
ETK61_RS20730	COG4506	Protein conserved in bacteria
ETK61_RS20745	COG0535	radical SAM domain protein
ETK61_RS20755	COG1131	(ABC) transporter
ETK61_RS20760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ETK61_RS20765	COG0612	Peptidase, M16
ETK61_RS20770	COG0612	Peptidase, M16
ETK61_RS20780	COG3391	amine dehydrogenase activity
ETK61_RS20785	COG3391	amine dehydrogenase activity
ETK61_RS20795	COG0457	Tetratricopeptide repeat
ETK61_RS20810	COG0010	Belongs to the arginase family
ETK61_RS20815	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ETK61_RS20820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ETK61_RS20835	COG1994	Peptidase M50
ETK61_RS20840	COG1942	4-Oxalocrotonate Tautomerase
ETK61_RS20845	COG1846	Transcriptional regulator
ETK61_RS20850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ETK61_RS20860	COG0477	Major facilitator Superfamily
ETK61_RS20865	COG1959	2 iron, 2 sulfur cluster binding
ETK61_RS20870	COG3465	dGTPase activity
ETK61_RS20875	COG1078	dGTPase activity
ETK61_RS20880	COG4844	belongs to the
ETK61_RS20890	COG0697	spore germination
ETK61_RS20895	COG0095	Lipoate-protein ligase
ETK61_RS20900	COG0583	DNA-binding transcription factor activity
ETK61_RS20905	COG0280	phosphate acetyltransferase
ETK61_RS20910	COG3253	May function as heme-dependent peroxidase
ETK61_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS20920	COG0436	Aminotransferase
ETK61_RS20925	COG2814	Major facilitator Superfamily
ETK61_RS20930	COG0151	Belongs to the GarS family
ETK61_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS20940	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS20945	COG0077	Prephenate dehydratase
ETK61_RS20950	COG2814	Major facilitator Superfamily
ETK61_RS20955	COG0833	amino acid
ETK61_RS20965	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS20970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ETK61_RS20980	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ETK61_RS20985	COG1091	dTDP-4-dehydrorhamnose reductase activity
ETK61_RS20990	COG1088	dTDP-glucose 4,6-dehydratase activity
ETK61_RS20995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ETK61_RS21000	COG3980	spore coat polysaccharide biosynthesis protein
ETK61_RS21005	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ETK61_RS21010	COG2089	acid synthase
ETK61_RS21015	COG0456	acetyltransferase
ETK61_RS21020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ETK61_RS21025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ETK61_RS21030	COG0463	Glycosyl transferase, family 2
ETK61_RS21050	COG2363	Small membrane protein
ETK61_RS21055	COG2233	PERMEase
ETK61_RS21065	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS21070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ETK61_RS21075	COG1216	Glycosyl transferase, family 2
ETK61_RS21090	COG1695	Transcriptional regulator
ETK61_RS21095	COG0351	phosphomethylpyrimidine kinase
ETK61_RS21105	COG1621	beta-fructofuranosidase activity
ETK61_RS21110	COG1263	PTS System
ETK61_RS21110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS21115	COG2116	formate transmembrane transporter activity
ETK61_RS21120	COG3711	transcriptional antiterminator
ETK61_RS21130	COG1404	Belongs to the peptidase S8 family
ETK61_RS21135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS21140	COG0778	Nitroreductase
ETK61_RS21145	COG0772	Belongs to the SEDS family
ETK61_RS21155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ETK61_RS21160	COG1845	cytochrome c oxidase, subunit III
ETK61_RS21165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ETK61_RS21170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ETK61_RS21175	COG2261	transglycosylase associated protein
ETK61_RS21180	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ETK61_RS21185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ETK61_RS21190	COG2246	polysaccharide biosynthetic process
ETK61_RS21195	COG1309	transcriptional regulator
ETK61_RS21205	COG3162	membrane
ETK61_RS21215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ETK61_RS21220	COG2837	iron assimilation
ETK61_RS21225	COG2822	iron ion transport
ETK61_RS21230	COG0672	)-iron permease
ETK61_RS21235	COG0352	thiamine-phosphate diphosphorylase activity
ETK61_RS21240	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ETK61_RS21245	COG0583	DNA-binding transcription factor activity
ETK61_RS21250	COG1380	Effector of murein hydrolase LrgA
ETK61_RS21255	COG1346	cytolysis
ETK61_RS21260	COG2814	Major facilitator Superfamily
ETK61_RS21265	COG4895	conserved protein (DUF2196)
ETK61_RS21270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ETK61_RS21275	COG0346	lactoylglutathione lyase activity
ETK61_RS21285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK61_RS21290	COG1404	Belongs to the peptidase S8 family
ETK61_RS21295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS21295	COG1263	PTS System
ETK61_RS21300	COG3711	transcriptional antiterminator
ETK61_RS21305	COG1442	glycosyl transferase family 8
ETK61_RS21310	COG5522	Integral membrane protein (intg_mem_TP0381)
ETK61_RS21315	COG1846	Transcriptional regulator
ETK61_RS21320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ETK61_RS21325	COG2234	aminopeptidase activity
ETK61_RS21340	COG2814	Major facilitator Superfamily
ETK61_RS21345	COG2357	RelA SpoT domain protein
ETK61_RS21355	COG1575	Belongs to the MenA family. Type 1 subfamily
ETK61_RS21375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ETK61_RS21380	COG1696	Membrane protein involved in D-alanine export
ETK61_RS21385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ETK61_RS21390	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ETK61_RS21395	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ETK61_RS21400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ETK61_RS21405	COG1486	melibiose metabolic process
ETK61_RS21410	COG1447	Phosphotransferase system cellobiose-specific component IIA
ETK61_RS21415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK61_RS21420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ETK61_RS21425	COG3711	transcriptional antiterminator
ETK61_RS21425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ETK61_RS21435	COG2094	Belongs to the DNA glycosylase MPG family
ETK61_RS21440	COG0753	catalase activity
ETK61_RS21450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ETK61_RS21455	COG1131	(ABC) transporter
ETK61_RS21475	COG1595	DNA-templated transcription, initiation
ETK61_RS21480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ETK61_RS21485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ETK61_RS21490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ETK61_RS21495	COG4988	ABC transporter
ETK61_RS21500	COG1294	oxidase, subunit
ETK61_RS21505	COG1271	oxidase subunit
ETK61_RS21510	COG3493	citrate carrier protein
ETK61_RS21515	COG0501	Belongs to the peptidase M48B family
ETK61_RS21525	COG0726	polysaccharide deacetylase
ETK61_RS21530	COG3842	ATPase activity
ETK61_RS21535	COG2508	Transcriptional regulator
ETK61_RS21540	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS21545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ETK61_RS21555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ETK61_RS21565	COG4585	Histidine kinase
ETK61_RS21570	COG2197	response regulator
ETK61_RS21575	COG2195	Cleaves the N-terminal amino acid of tripeptides
ETK61_RS21585	COG4894	glucomannan catabolic process
ETK61_RS21590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETK61_RS21595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ETK61_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS21605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ETK61_RS21610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ETK61_RS21615	COG2610	gluconate transmembrane transporter activity
ETK61_RS21620	COG0500	methyltransferase
ETK61_RS21625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK61_RS21640	COG0693	protein deglycase activity
ETK61_RS21640	COG0753	catalase activity
ETK61_RS21645	COG2851	Citrate transporter
ETK61_RS21650	COG2273	Hydrolase Family 16
ETK61_RS21670	COG2270	Major facilitator Superfamily
ETK61_RS21675	COG0513	Belongs to the DEAD box helicase family
ETK61_RS21680	COG3401	FG-GAP repeat protein
ETK61_RS21680	COG2755	lipolytic protein G-D-S-L family
ETK61_RS21810	COG0697	spore germination
ETK61_RS21815	COG0589	response to stress
ETK61_RS21820	COG2723	6-phospho-beta-galactosidase activity
ETK61_RS21825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ETK61_RS21825	COG2190	(PTS) system
ETK61_RS21825	COG1263	PTS System
ETK61_RS21835	COG5444	nuclease activity
ETK61_RS21855	COG0494	nUDIX hydrolase
ETK61_RS21860	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ETK61_RS21865	COG3507	Belongs to the glycosyl hydrolase 43 family
ETK61_RS21875	COG1228	amidohydrolase
ETK61_RS21885	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ETK61_RS21890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ETK61_RS21895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ETK61_RS21900	COG2390	Transcriptional regulator
ETK61_RS21910	COG3192	ethanolamine utilization protein
ETK61_RS21915	COG2079	MmgE PrpD family protein
ETK61_RS21920	COG1473	amidohydrolase
ETK61_RS21925	COG1126	abc transporter atp-binding protein
ETK61_RS21930	COG0765	amino acid transport
ETK61_RS21935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ETK61_RS21940	COG0456	acetyltransferase
ETK61_RS21945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ETK61_RS21950	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ETK61_RS21955	COG0561	phosphatase activity
ETK61_RS21985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ETK61_RS21990	COG5294	Protein conserved in bacteria
ETK61_RS22005	COG2205	protein histidine kinase activity
ETK61_RS22010	COG0745	RESPONSE REGULATOR receiver
ETK61_RS22015	COG0191	fructose-bisphosphate aldolase activity
ETK61_RS22020	COG1082	Xylose isomerase domain protein TIM barrel
ETK61_RS22025	COG1082	Xylose isomerase domain protein TIM barrel
ETK61_RS22030	COG0673	inositol 2-dehydrogenase activity
ETK61_RS22040	COG1082	Xylose isomerase domain protein TIM barrel
ETK61_RS22045	COG3962	Belongs to the TPP enzyme family
ETK61_RS22050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ETK61_RS22065	COG1349	DNA-binding transcription factor activity
ETK61_RS22070	COG0667	Aldo Keto reductase
ETK61_RS22100	COG0326	Molecular chaperone. Has ATPase activity
ETK61_RS22115	COG1309	transcriptional regulator
ETK61_RS22120	COG1012	belongs to the aldehyde dehydrogenase family
ETK61_RS22130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ETK61_RS22140	COG1714	RDD family
ETK61_RS22145	COG2311	Membrane
ETK61_RS22150	COG1917	Cupin 2, conserved barrel domain protein
ETK61_RS22155	COG1309	transcriptional regulator
ETK61_RS22160	COG1028	Short-chain dehydrogenase reductase Sdr
ETK61_RS22170	COG1846	Transcriptional regulator
ETK61_RS22175	COG1380	Effector of murein hydrolase LrgA
ETK61_RS22180	COG1346	cytolysis
ETK61_RS22185	COG5039	Polysaccharide pyruvyl transferase
ETK61_RS22190	COG1929	Belongs to the glycerate kinase type-1 family
ETK61_RS22195	COG1802	Transcriptional regulator
ETK61_RS22200	COG1070	Carbohydrate kinase
ETK61_RS22205	COG2610	gluconate transmembrane transporter activity
ETK61_RS22210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ETK61_RS22215	COG0450	alkyl hydroperoxide reductase
ETK61_RS22220	COG3634	alkyl hydroperoxide reductase activity
ETK61_RS22225	COG2723	6-phospho-beta-galactosidase activity
ETK61_RS22240	COG2188	Transcriptional regulator
ETK61_RS22255	COG1131	(ABC) transporter
ETK61_RS22260	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ETK61_RS22285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ETK61_RS22300	COG1063	alcohol dehydrogenase
ETK61_RS22320	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ETK61_RS22325	COG0456	acetyltransferase
ETK61_RS22330	COG0457	Tetratricopeptide repeat
ETK61_RS22345	COG0010	Belongs to the arginase family
ETK61_RS22350	COG0833	amino acid
ETK61_RS22355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ETK61_RS22360	COG3829	transcription factor binding
ETK61_RS22365	COG5002	protein histidine kinase activity
ETK61_RS22370	COG0745	RESPONSE REGULATOR receiver
ETK61_RS22390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ETK61_RS22395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ETK61_RS22400	COG4853	Protein conserved in bacteria
ETK61_RS22405	COG4863	YycH protein
ETK61_RS22410	COG5002	protein histidine kinase activity
ETK61_RS22415	COG0745	RESPONSE REGULATOR receiver
ETK61_RS22450	COG0305	Participates in initiation and elongation during chromosome replication
ETK61_RS22465	COG3093	addiction module antidote protein HigA
ETK61_RS22470	COG2807	transmembrane transport
ETK61_RS22475	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ETK61_RS22480	COG0359	binds to the 23S rRNA
ETK61_RS22485	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ETK61_RS22490	COG4241	membrane
ETK61_RS22505	COG1733	regulation of RNA biosynthetic process
ETK61_RS22510	COG1227	inorganic diphosphatase activity
ETK61_RS22520	COG2271	Major facilitator Superfamily
ETK61_RS22525	COG0789	Transcriptional regulator
ETK61_RS22525	COG4978	Transcriptional regulator
ETK61_RS22535	COG4319	ketosteroid isomerase
ETK61_RS22540	COG1357	PFAM Pentapeptide repeats (8 copies)
ETK61_RS22545	COG2814	Major facilitator Superfamily
ETK61_RS22550	COG0583	DNA-binding transcription factor activity
ETK61_RS22555	COG2153	protein acetylation
ETK61_RS22570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ETK61_RS22575	COG1846	Transcriptional regulator
ETK61_RS22580	COG2153	protein acetylation
ETK61_RS22585	COG2364	Membrane
ETK61_RS22590	COG0456	acetyltransferase
ETK61_RS22595	COG2315	Protein conserved in bacteria
ETK61_RS22600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ETK61_RS22610	COG2814	Major facilitator Superfamily
ETK61_RS22620	COG1331	Highly conserved protein containing a thioredoxin domain
ETK61_RS22635	COG0789	Transcriptional regulator
ETK61_RS22640	COG0697	spore germination
ETK61_RS22650	COG1280	lysine exporter protein (LysE YggA)
ETK61_RS22655	COG1331	Highly conserved protein containing a thioredoxin domain
ETK61_RS22660	COG1331	Highly conserved protein containing a thioredoxin domain
ETK61_RS22665	COG1266	CAAX protease self-immunity
ETK61_RS22675	COG0110	maltose O-acetyltransferase activity
ETK61_RS22680	COG0346	lactoylglutathione lyase activity
ETK61_RS22690	COG1609	Transcriptional regulator
ETK61_RS22695	COG0708	Exodeoxyribonuclease III
ETK61_RS22700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ETK61_RS22705	COG0629	single-stranded DNA binding
ETK61_RS22710	COG0360	Binds together with S18 to 16S ribosomal RNA
ETK61_RS22715	COG0012	GTP binding
ETK61_RS22720	COG0243	molybdopterin cofactor binding
ETK61_RS22725	COG4481	Protein conserved in bacteria
ETK61_RS22730	COG3949	Membrane
ETK61_RS22740	COG1475	DNA binding
ETK61_RS22745	COG1192	Involved in chromosome partitioning
ETK61_RS22755	COG1475	DNA binding
ETK61_RS22760	COG0357	Ribosomal RNA small subunit methyltransferase G
ETK61_RS22765	COG0445	tRNA wobble uridine modification
ETK61_RS22770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ETK61_RS22775	COG1847	R3H domain protein
ETK61_RS22780	COG0706	membrane insertase activity
ETK61_RS22785	COG0594	ribonuclease P activity
ETK61_RS22820	COG5632	N-Acetylmuramoyl-L-alanine amidase
ETK61_RS22835	COG0457	Tetratricopeptide repeat
ETK61_RS22855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ETK61_RS22880	COG5444	nuclease activity
ETK61_RS22890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ETK61_RS22900	COG3331	DNA recombination
ETK61_RS22960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ETK61_RS23115	COG1024	Enoyl-CoA hydratase
ETK61_RS23125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ETK61_RS23130	COG3534	alpha-L-arabinofuranosidase
ETK61_RS23135	COG3118	belongs to the thioredoxin family
ETK61_RS23140	COG0322	excinuclease ABC activity
ETK61_RS23150	COG0527	aspartate kinase activity
ETK61_RS23155	COG1719	4-vinyl reductase, 4VR
ETK61_RS23160	COG2009	succinate dehydrogenase
ETK61_RS23165	COG1053	succinate dehydrogenase
ETK61_RS23170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ETK61_RS23175	COG0824	Thioesterase
ETK61_RS23180	COG2197	response regulator
ETK61_RS23185	COG1846	Transcriptional regulator
ETK61_RS23190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ETK61_RS23195	COG5401	PFAM Sporulation and spore germination
ETK61_RS23200	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ETK61_RS23205	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ETK61_RS23210	COG0622	Phosphoesterase
ETK61_RS23225	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ETK61_RS23245	COG0028	Belongs to the TPP enzyme family
ETK61_RS23250	COG0440	acetolactate synthase activity
ETK61_RS23265	COG0473	3-isopropylmalate dehydrogenase activity
ETK61_RS23275	COG0066	3-isopropylmalate dehydratase activity
ETK61_RS23300	COG0456	acetyltransferase
ETK61_RS23305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ETK61_RS23310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ETK61_RS23315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ETK61_RS23320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ETK61_RS23335	COG0456	acetyltransferase
ETK61_RS23340	COG0463	Glycosyl transferase, family 2
ETK61_RS23355	COG4641	Protein conserved in bacteria
ETK61_RS23360	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ETK61_RS23365	COG1086	Polysaccharide biosynthesis protein
ETK61_RS23370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK61_RS23375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ETK61_RS23380	COG1846	Transcriptional regulator
ETK61_RS23385	COG0534	Mate efflux family protein
ETK61_RS23395	COG4698	Protein conserved in bacteria
ETK61_RS23400	COG2755	lipolytic protein G-D-S-L family
ETK61_RS23405	COG1999	signal sequence binding
ETK61_RS23415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ETK61_RS23420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ETK61_RS23425	COG1272	protein, Hemolysin III
ETK61_RS23430	COG0204	Acyl-transferase
ETK61_RS23435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ETK61_RS23450	COG2521	methyltransferase
ETK61_RS23450	COG2136	Putative SAM-dependent methyltransferase