locus-tag	class	description
ES965_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES965_RS00010	COG0592	DNA-directed DNA polymerase activity
ES965_RS00015	COG2501	S4 domain
ES965_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES965_RS00030	COG0187	DNA topoisomerase II activity
ES965_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES965_RS00070	COG0516	GMP reductase activity
ES965_RS00070	COG0517	IMP dehydrogenase activity
ES965_RS00075	COG1686	Belongs to the peptidase S11 family
ES965_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES965_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES965_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES965_RS00100	COG1428	Deoxynucleoside kinase
ES965_RS00105	COG1428	Deoxynucleoside kinase
ES965_RS00110	COG3858	chitin binding
ES965_RS00110	COG1388	LysM domain
ES965_RS00115	COG1335	isochorismatase
ES965_RS00120	COG0590	tRNA wobble adenosine to inosine editing
ES965_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES965_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES965_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES965_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES965_RS00190	COG3853	Toxic anion resistance protein (TelA)
ES965_RS00195	COG1982	Orn Lys Arg decarboxylase major
ES965_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES965_RS00205	COG3870	Protein conserved in bacteria
ES965_RS00210	COG1728	Protein conserved in bacteria
ES965_RS00215	COG0470	DNA polymerase III
ES965_RS00220	COG1774	PSP1 C-terminal conserved region
ES965_RS00225	COG4467	Involved in initiation control of chromosome replication
ES965_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES965_RS00235	COG2827	Endonuclease containing a URI domain
ES965_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES965_RS00245	COG2002	toxin-antitoxin pair type II binding
ES965_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_RS00255	COG0084	hydrolase, TatD family'
ES965_RS00260	COG3584	3D domain protein
ES965_RS00260	COG3583	domain protein
ES965_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES965_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES965_RS00280	COG4466	Protein conserved in bacteria
ES965_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES965_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_RS00300	COG0251	oxidation-reduction process
ES965_RS00305	COG2088	sporulation resulting in formation of a cellular spore
ES965_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES965_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES965_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES965_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
ES965_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES965_RS00340	COG2002	toxin-antitoxin pair type II binding
ES965_RS00345	COG2244	polysaccharide biosynthetic process
ES965_RS00350	COG3956	TIGRFAM MazG family protein
ES965_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES965_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES965_RS00375	COG1098	S1 RNA binding domain
ES965_RS00390	COG2208	phosphoserine phosphatase activity
ES965_RS00395	COG2304	oxidoreductase activity
ES965_RS00400	COG0515	serine threonine protein kinase
ES965_RS00405	COG0037	tRNA processing
ES965_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ES965_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES965_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES965_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES965_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES965_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES965_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ES965_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES965_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES965_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES965_RS00470	COG1396	sequence-specific DNA binding
ES965_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES965_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES965_RS00560	COG4463	regulation of RNA biosynthetic process
ES965_RS00565	COG3880	PFAM UvrB UvrC protein
ES965_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES965_RS00575	COG0542	response to heat
ES965_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES965_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES965_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
ES965_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES965_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES965_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES965_RS00615	COG1045	serine acetyltransferase
ES965_RS00620	COG0215	cysteine-tRNA ligase activity
ES965_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES965_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES965_RS00635	COG3688	RNA-binding protein containing a PIN domain
ES965_RS00640	COG1595	DNA-templated transcription, initiation
ES965_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES965_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
ES965_RS00665	COG0081	regulation of translation
ES965_RS00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES965_RS00680	COG2813	Specifically methylates the guanine in position
ES965_RS00685	COG0085	RNA polymerase activity
ES965_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES965_RS00695	COG1358	cellular component organization or biogenesis
ES965_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES965_RS00705	COG0049	tRNA binding
ES965_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES965_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES965_RS00720	COG0596	Alpha beta hydrolase
ES965_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES965_RS00735	COG0088	Forms part of the polypeptide exit tunnel
ES965_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES965_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES965_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES965_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES965_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES965_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES965_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES965_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES965_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES965_RS00825	COG0200	Binds to the 23S rRNA
ES965_RS00830	COG0201	protein transport
ES965_RS00835	COG0563	adenylate kinase activity
ES965_RS00840	COG0024	Methionine aminopeptidase
ES965_RS00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES965_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES965_RS00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES965_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES965_RS00870	COG0202	RNA polymerase activity
ES965_RS00875	COG0203	ribosomal protein L17
ES965_RS00880	COG1122	ATPase activity
ES965_RS00885	COG1122	ATPase activity
ES965_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES965_RS00895	COG0101	tRNA pseudouridine synthase activity
ES965_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES965_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES965_RS00910	COG2226	methyltransferase
ES965_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS00925	COG0489	protein tyrosine kinase activity
ES965_RS00935	COG2194	sulfuric ester hydrolase activity
ES965_RS00940	COG0726	polysaccharide deacetylase
ES965_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
ES965_RS01030	COG0385	Bile acid
ES965_RS01035	COG2819	hydrolase of the alpha beta superfamily
ES965_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS01055	COG2207	Transcriptional regulator
ES965_RS01060	COG3876	Protein conserved in bacteria
ES965_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ES965_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS01075	COG1263	PTS System
ES965_RS01080	COG1737	Transcriptional regulator
ES965_RS01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES965_RS01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS01095	COG1683	Conserved Protein
ES965_RS01125	COG1595	DNA-templated transcription, initiation
ES965_RS01130	COG5662	AntiSigma factor
ES965_RS01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES965_RS01140	COG4856	YbbR-like protein
ES965_RS01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES965_RS01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES965_RS01160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES965_RS01165	COG2169	Transcriptional regulator
ES965_RS01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES965_RS01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES965_RS01180	COG3002	Belongs to the UPF0753 family
ES965_RS01185	COG0288	reversible hydration of carbon dioxide
ES965_RS01195	COG5609	conserved protein (DUF2294)
ES965_RS01200	COG0640	Transcriptional regulator
ES965_RS01205	COG2814	Major facilitator Superfamily
ES965_RS01220	COG0596	Alpha beta hydrolase
ES965_RS01225	COG0745	RESPONSE REGULATOR receiver
ES965_RS01230	COG0642	Histidine kinase
ES965_RS01240	COG0515	serine threonine protein kinase
ES965_RS01255	COG1113	amino acid transport
ES965_RS01275	COG2124	cytochrome p450
ES965_RS01285	COG0531	amino acid
ES965_RS01290	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_RS01295	COG2271	Major facilitator Superfamily
ES965_RS01310	COG0456	acetyltransferase
ES965_RS01310	COG1846	Transcriptional regulator
ES965_RS01315	COG2271	Major facilitator Superfamily
ES965_RS01325	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS01330	COG0697	spore germination
ES965_RS01335	COG2207	Transcriptional regulator
ES965_RS01335	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS01340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES965_RS01345	COG3591	Belongs to the peptidase S1B family
ES965_RS01355	COG0596	Alpha beta hydrolase
ES965_RS01360	COG1183	phosphatidylcholine synthase activity
ES965_RS01365	COG0586	Pfam SNARE associated Golgi protein
ES965_RS01370	COG0688	phosphatidylethanolamine metabolic process
ES965_RS01380	COG2312	Erythromycin esterase
ES965_RS01385	COG1054	Belongs to the UPF0176 family
ES965_RS01390	COG1301	dicarboxylic acid transport
ES965_RS01395	COG1263	PTS System
ES965_RS01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS01395	COG2190	(PTS) system
ES965_RS01400	COG0363	glucosamine-6-phosphate deaminase activity
ES965_RS01405	COG2188	Transcriptional regulator
ES965_RS01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_RS01420	COG0833	amino acid
ES965_RS01425	COG2040	homocysteine
ES965_RS01435	COG1115	amino acid carrier protein
ES965_RS01440	COG2066	Belongs to the glutaminase family
ES965_RS01445	COG4191	Histidine kinase
ES965_RS01450	COG0784	Response regulator, receiver
ES965_RS01460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES965_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS01470	COG2271	Major facilitator Superfamily
ES965_RS01475	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_RS01480	COG2186	Transcriptional regulator
ES965_RS01485	COG2721	sulfolactate sulfo-lyase activity
ES965_RS01490	COG3173	Aminoglycoside phosphotransferase
ES965_RS01505	COG0745	RESPONSE REGULATOR receiver
ES965_RS01510	COG2205	protein histidine kinase activity
ES965_RS01515	COG1131	(ABC) transporter
ES965_RS01535	COG3773	Cell wall hydrolase
ES965_RS01540	COG2304	oxidoreductase activity
ES965_RS01550	COG3540	Alkaline phosphatase
ES965_RS01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_RS01560	COG0805	protein transport
ES965_RS01565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES965_RS01570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES965_RS01575	COG0477	Major facilitator Superfamily
ES965_RS01580	COG1309	transcriptional regulator
ES965_RS01585	COG0252	asparaginase activity
ES965_RS01595	COG1714	RDD family
ES965_RS01600	COG1405	negative regulation of cell septum assembly
ES965_RS01600	COG3012	SEC-C Motif Domain Protein
ES965_RS01605	COG3290	protein histidine kinase activity
ES965_RS01610	COG3279	Response regulator of the LytR AlgR family
ES965_RS01615	COG4555	ABC transporter
ES965_RS01620	COG1668	transmembrane transport
ES965_RS01625	COG0667	Aldo Keto reductase
ES965_RS01640	COG1595	DNA-templated transcription, initiation
ES965_RS01645	COG1595	DNA-templated transcription, initiation
ES965_RS01650	COG1876	peptidase activity
ES965_RS01655	COG0457	Tetratricopeptide repeat
ES965_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS01665	COG0366	Alpha amylase catalytic
ES965_RS01670	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES965_RS01675	COG1121	(ABC) transporter
ES965_RS01680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS01690	COG2310	stress, protein
ES965_RS01695	COG2310	stress, protein
ES965_RS01700	COG2310	stress, protein
ES965_RS01705	COG0861	Integral membrane protein TerC family
ES965_RS01715	COG3853	Toxic anion resistance protein (TelA)
ES965_RS01720	COG0477	Major facilitator Superfamily
ES965_RS01730	COG2814	Major facilitator Superfamily
ES965_RS01735	COG0640	Transcriptional regulator
ES965_RS01740	COG4175	Glycine betaine
ES965_RS01740	COG0517	IMP dehydrogenase activity
ES965_RS01745	COG4176	ABC-type proline glycine betaine transport system permease component
ES965_RS01750	COG2113	Glycine betaine
ES965_RS01755	COG1473	amidohydrolase
ES965_RS01760	COG1288	antiporter activity
ES965_RS01770	COG0366	Alpha amylase catalytic
ES965_RS01775	COG0039	L-malate dehydrogenase activity
ES965_RS01780	COG1620	l-lactate permease
ES965_RS01785	COG2814	Major facilitator Superfamily
ES965_RS01790	COG1846	Transcriptional regulator
ES965_RS01795	COG1280	lysine exporter protein (LysE YggA)
ES965_RS01800	COG3403	YqcI/YcgG family
ES965_RS01805	COG1113	amino acid transport
ES965_RS01810	COG3665	Urea carboxylase-associated protein
ES965_RS01815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES965_RS01820	COG1660	Displays ATPase and GTPase activities
ES965_RS01825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES965_RS01830	COG2226	methyltransferase
ES965_RS01835	COG0583	DNA-binding transcription factor activity
ES965_RS01840	COG3458	cephalosporin-C deacetylase activity
ES965_RS01845	COG3541	Predicted nucleotidyltransferase
ES965_RS01850	COG0506	proline dehydrogenase activity
ES965_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS01860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_RS01865	COG2508	Transcriptional regulator
ES965_RS01870	COG3689	TIGRFAM TIGR03943 family protein
ES965_RS01875	COG0701	Predicted permease
ES965_RS01880	COG2267	carboxylic ester hydrolase activity
ES965_RS01885	COG0492	ferredoxin-NADP+ reductase activity
ES965_RS01890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES965_RS01890	COG1587	Uroporphyrinogen-III synthase
ES965_RS01895	COG2146	nitrite reductase [NAD(P)H] activity
ES965_RS01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_RS01905	COG0243	molybdopterin cofactor binding
ES965_RS01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_RS01915	COG2223	nitrite transmembrane transporter activity
ES965_RS01920	COG1469	GTP cyclohydrolase I activity
ES965_RS01925	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_RS01935	COG0523	cobalamin synthesis protein
ES965_RS01940	COG0765	amino acid transport
ES965_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS01955	COG1714	RDD family
ES965_RS01965	COG2723	6-phospho-beta-galactosidase activity
ES965_RS01975	COG3209	COG3209 Rhs family protein
ES965_RS01980	COG0840	transmembrane signaling receptor activity
ES965_RS01980	COG3290	protein histidine kinase activity
ES965_RS01985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES965_RS01990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES965_RS01995	COG1733	regulation of RNA biosynthetic process
ES965_RS02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS02015	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES965_RS02020	COG2814	Major facilitator Superfamily
ES965_RS02030	COG0697	spore germination
ES965_RS02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS02045	COG2364	Membrane
ES965_RS02050	COG1126	abc transporter atp-binding protein
ES965_RS02055	COG0765	amino acid transport
ES965_RS02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS02065	COG0583	DNA-binding transcription factor activity
ES965_RS02070	COG0163	prenyltransferase activity
ES965_RS02075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES965_RS02090	COG0596	Alpha beta hydrolase
ES965_RS02095	COG3104	oligopeptide transport
ES965_RS02100	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_RS02110	COG0697	spore germination
ES965_RS02120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES965_RS02125	COG1136	(ABC) transporter
ES965_RS02130	COG0577	efflux transmembrane transporter activity
ES965_RS02135	COG0745	RESPONSE REGULATOR receiver
ES965_RS02140	COG3850	Histidine kinase
ES965_RS02140	COG5002	protein histidine kinase activity
ES965_RS02145	COG0457	Tetratricopeptide repeat
ES965_RS02165	COG0527	aspartate kinase activity
ES965_RS02170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS02175	COG4605	iron ion homeostasis
ES965_RS02180	COG4604	ABC transporter, ATP-binding protein
ES965_RS02185	COG4607	ABC-type enterochelin transport system periplasmic component
ES965_RS02190	COG2814	Major facilitator Superfamily
ES965_RS02195	COG1309	transcriptional regulator
ES965_RS02200	COG0778	Nitroreductase
ES965_RS02205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES965_RS02210	COG0640	Transcriptional regulator
ES965_RS02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES965_RS02225	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS02230	COG4975	Glucose uptake
ES965_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS02240	COG4549	nuclear export factor GLE1
ES965_RS02245	COG1276	copper resistance
ES965_RS02245	COG2372	response to copper ion
ES965_RS02250	COG1349	DNA-binding transcription factor activity
ES965_RS02260	COG2213	PTS system mannitol-specific
ES965_RS02265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS02270	COG0246	Mannitol dehydrogenase
ES965_RS02275	COG0473	3-isopropylmalate dehydrogenase activity
ES965_RS02280	COG0681	Belongs to the peptidase S26 family
ES965_RS02285	COG0412	Dienelactone hydrolase
ES965_RS02290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES965_RS02300	COG0561	phosphatase activity
ES965_RS02305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES965_RS02310	COG1914	H( )-stimulated, divalent metal cation uptake system
ES965_RS02315	COG4336	lyase activity
ES965_RS02320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES965_RS02325	COG1984	allophanate hydrolase subunit 2
ES965_RS02330	COG1414	Transcriptional regulator
ES965_RS02335	COG2755	lipolytic protein G-D-S-L family
ES965_RS02345	COG2329	Antibiotic biosynthesis monooxygenase
ES965_RS02350	COG0768	penicillin binding
ES965_RS02355	COG4989	oxidoreductase activity
ES965_RS02360	COG3711	transcriptional antiterminator
ES965_RS02365	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS02370	COG2226	methyltransferase
ES965_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS02380	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS02385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS02390	COG3871	stress protein (general stress protein 26)
ES965_RS02400	COG2814	Major facilitator Superfamily
ES965_RS02405	COG1522	sequence-specific DNA binding
ES965_RS02410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES965_RS02410	COG0551	DNA topoisomerase type I activity
ES965_RS02415	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ES965_RS02420	COG3706	GGDEF domain
ES965_RS02425	COG5298	Protein conserved in bacteria
ES965_RS02430	COG1215	transferase activity, transferring glycosyl groups
ES965_RS02440	COG0531	amino acid
ES965_RS02445	COG0494	nUDIX hydrolase
ES965_RS02450	COG0028	Belongs to the TPP enzyme family
ES965_RS02465	COG1914	H( )-stimulated, divalent metal cation uptake system
ES965_RS02470	COG2261	transglycosylase associated protein
ES965_RS02475	COG4876	unkown
ES965_RS02480	COG2217	Heavy metal translocating P-type atpase
ES965_RS02485	COG3729	General stress protein
ES965_RS02490	COG0662	Cupin 2, conserved barrel domain protein
ES965_RS02495	COG2329	Antibiotic biosynthesis monooxygenase
ES965_RS02500	COG3546	catalase activity
ES965_RS02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES965_RS02510	COG3290	protein histidine kinase activity
ES965_RS02515	COG4565	transcriptional regulatory protein
ES965_RS02520	COG1301	dicarboxylic acid transport
ES965_RS02525	COG0628	permease
ES965_RS02530	COG1131	(ABC) transporter
ES965_RS02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_RS02545	COG1960	acyl-CoA dehydrogenase activity
ES965_RS02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES965_RS02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES965_RS02585	COG0513	Belongs to the DEAD box helicase family
ES965_RS02590	COG3402	PFAM membrane-flanked domain
ES965_RS02595	COG3428	Bacterial PH domain
ES965_RS02600	COG0705	Rhomboid family
ES965_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
ES965_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES965_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES965_RS02620	COG0864	Transcriptional regulator
ES965_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES965_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS02640	COG2172	sigma factor antagonist activity
ES965_RS02645	COG2208	phosphoserine phosphatase activity
ES965_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS02655	COG2172	sigma factor antagonist activity
ES965_RS02660	COG1191	sigma factor activity
ES965_RS02665	COG2208	phosphoserine phosphatase activity
ES965_RS02670	COG2183	response to ionizing radiation
ES965_RS02680	COG3091	SprT-like family
ES965_RS02730	COG0515	serine threonine protein kinase
ES965_RS02735	COG0515	serine threonine protein kinase
ES965_RS02740	COG1132	(ABC) transporter
ES965_RS02755	COG1476	TRANSCRIPTIONal
ES965_RS02765	COG3239	Fatty acid desaturase
ES965_RS02775	COG1278	Cold shock
ES965_RS02780	COG1329	Transcriptional regulator
ES965_RS02790	COG0697	spore germination
ES965_RS02795	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS02795	COG2207	Transcriptional regulator
ES965_RS02800	COG0697	spore germination
ES965_RS02805	COG3708	Transcriptional regulator
ES965_RS02805	COG2207	Transcriptional regulator
ES965_RS02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS02815	COG0477	Major facilitator Superfamily
ES965_RS02825	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES965_RS02845	COG1309	transcriptional regulator
ES965_RS02850	COG0697	spore germination
ES965_RS02855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS02860	COG2030	dehydratase
ES965_RS02865	COG3545	Serine hydrolase
ES965_RS02870	COG1733	regulation of RNA biosynthetic process
ES965_RS02875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS02880	COG1733	regulation of RNA biosynthetic process
ES965_RS02885	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_RS02890	COG2814	Major facilitator Superfamily
ES965_RS02895	COG1309	transcriptional regulator
ES965_RS02900	COG0640	Transcriptional regulator
ES965_RS02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES965_RS02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS02920	COG1316	TRANSCRIPTIONal
ES965_RS02935	COG5002	protein histidine kinase activity
ES965_RS02940	COG0745	RESPONSE REGULATOR receiver
ES965_RS02945	COG0697	spore germination
ES965_RS02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES965_RS02960	COG0640	Transcriptional regulator
ES965_RS02965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES965_RS02980	COG4585	Histidine kinase
ES965_RS02985	COG2197	response regulator
ES965_RS02990	COG2409	Drug exporters of the RND superfamily
ES965_RS02995	COG0596	Alpha beta hydrolase
ES965_RS03000	COG1811	Na channel or pump
ES965_RS03005	COG4978	Transcriptional regulator
ES965_RS03005	COG0789	Transcriptional regulator
ES965_RS03010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_RS03020	COG0346	lactoylglutathione lyase activity
ES965_RS03025	COG2259	Doxx family
ES965_RS03030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS03045	COG2323	membrane
ES965_RS03050	COG2323	membrane
ES965_RS03055	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_RS03070	COG1309	transcriptional regulator
ES965_RS03080	COG0456	acetyltransferase
ES965_RS03085	COG0488	(ABC) transporter
ES965_RS03090	COG1113	amino acid transport
ES965_RS03095	COG2318	DinB family
ES965_RS03100	COG1846	Transcriptional regulator
ES965_RS03105	COG2409	Drug exporters of the RND superfamily
ES965_RS03105	COG1033	growth of symbiont in host cell
ES965_RS03110	COG0778	Nitroreductase
ES965_RS03115	COG1846	Transcriptional regulator
ES965_RS03120	COG2814	Major facilitator Superfamily
ES965_RS03125	COG0730	response to heat
ES965_RS03130	COG1802	Transcriptional regulator
ES965_RS03135	COG1388	LysM domain
ES965_RS03135	COG3858	chitin binding
ES965_RS03140	COG1819	glycosyl
ES965_RS03150	COG1785	Belongs to the alkaline phosphatase family
ES965_RS03155	COG5646	InterPro IPR014922
ES965_RS03165	COG0454	-acetyltransferase
ES965_RS03170	COG1078	dGTPase activity
ES965_RS03175	COG1388	LysM domain
ES965_RS03180	COG2814	Major facilitator Superfamily
ES965_RS03185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_RS03190	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES965_RS03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_RS03200	COG2723	6-phospho-beta-galactosidase activity
ES965_RS03205	COG2188	Transcriptional regulator
ES965_RS03210	COG1940	carbohydrate kinase activity
ES965_RS03215	COG1482	cell wall glycoprotein biosynthetic process
ES965_RS03220	COG4124	Belongs to the glycosyl hydrolase 26 family
ES965_RS03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES965_RS03270	COG0802	atpase or kinase
ES965_RS03275	COG1214	PFAM Peptidase M22, glycoprotease
ES965_RS03280	COG0456	acetyltransferase
ES965_RS03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES965_RS03290	COG0488	(ABC) transporter
ES965_RS03295	COG0315	cyclic pyranopterin monophosphate synthase activity
ES965_RS03300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES965_RS03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_RS03310	COG0805	protein transport
ES965_RS03325	COG1266	CAAX protease self-immunity
ES965_RS03335	COG0459	protein refolding
ES965_RS03360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES965_RS03365	COG0457	Tetratricopeptide repeat
ES965_RS03370	COG1063	alcohol dehydrogenase
ES965_RS03375	COG2211	Major facilitator Superfamily
ES965_RS03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_RS03385	COG1842	Phage shock protein A
ES965_RS03390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES965_RS03395	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES965_RS03400	COG4260	virion core protein, lumpy skin disease virus
ES965_RS03410	COG2814	Major facilitator Superfamily
ES965_RS03415	COG1063	alcohol dehydrogenase
ES965_RS03420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES965_RS03425	COG0823	Involved in the tonB-independent uptake of proteins
ES965_RS03440	COG2267	carboxylic ester hydrolase activity
ES965_RS03450	COG2132	Multicopper oxidase
ES965_RS03455	COG1113	amino acid transport
ES965_RS03465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_RS03470	COG0714	Associated with various cellular activities
ES965_RS03475	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES965_RS03480	COG1305	Transglutaminase-like
ES965_RS03485	COG0519	Catalyzes the synthesis of GMP from XMP
ES965_RS03485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES965_RS03500	COG2252	PERMEase
ES965_RS03505	COG3064	Membrane
ES965_RS03515	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES965_RS03525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES965_RS03530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES965_RS03535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES965_RS03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES965_RS03545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES965_RS03550	COG0047	phosphoribosylformylglycinamidine synthase activity
ES965_RS03555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES965_RS03560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES965_RS03565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES965_RS03570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES965_RS03575	COG0138	bifunctional purine biosynthesis protein purh
ES965_RS03580	COG0151	Belongs to the GarS family
ES965_RS03585	COG1522	sequence-specific DNA binding
ES965_RS03590	COG0531	amino acid
ES965_RS03600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES965_RS03605	COG1470	cell adhesion involved in biofilm formation
ES965_RS03610	COG4496	protein, YerC YecD
ES965_RS03615	COG0069	glutamate synthase activity
ES965_RS03620	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES965_RS03625	COG0210	DNA helicase
ES965_RS03630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES965_RS03635	COG4851	CamS sex pheromone cAM373 precursor
ES965_RS03640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_RS03645	COG1285	pathogenesis
ES965_RS03650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_RS03655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES965_RS03660	COG0154	amidase activity
ES965_RS03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES965_RS03670	COG1309	transcriptional regulator
ES965_RS03675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES965_RS03680	COG1597	lipid kinase activity
ES965_RS03685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES965_RS03710	COG0457	Tetratricopeptide repeat
ES965_RS03725	COG5444	nuclease activity
ES965_RS03730	COG3391	amine dehydrogenase activity
ES965_RS03740	COG0457	Tetratricopeptide repeat
ES965_RS03750	COG0217	transcriptional regulatory protein
ES965_RS03760	COG1309	transcriptional regulator
ES965_RS03765	COG3631	Ketosteroid isomerase-related protein
ES965_RS03785	COG3546	catalase activity
ES965_RS03790	COG0454	-acetyltransferase
ES965_RS03800	COG5578	integral membrane protein
ES965_RS03805	COG2972	Histidine kinase
ES965_RS03810	COG2207	Transcriptional regulator
ES965_RS03810	COG4753	response regulator
ES965_RS03815	COG1653	transport
ES965_RS03820	COG1175	transmembrane transport
ES965_RS03825	COG0395	ABC-type sugar transport system, permease component
ES965_RS03830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES965_RS03835	COG2207	Transcriptional regulator
ES965_RS03840	COG2755	lipolytic protein G-D-S-L family
ES965_RS03850	COG5578	integral membrane protein
ES965_RS03855	COG3401	FG-GAP repeat protein
ES965_RS03860	COG3401	FG-GAP repeat protein
ES965_RS03865	COG2755	lipolytic protein G-D-S-L family
ES965_RS03870	COG1874	Beta-galactosidase
ES965_RS03880	COG1653	transport
ES965_RS03885	COG4209	transmembrane transport
ES965_RS03890	COG0395	ABC-type sugar transport system, permease component
ES965_RS03895	COG1486	melibiose metabolic process
ES965_RS03900	COG2323	membrane
ES965_RS03905	COG2329	Antibiotic biosynthesis monooxygenase
ES965_RS03910	COG0346	lactoylglutathione lyase activity
ES965_RS03925	COG5583	Uncharacterized small protein (DUF2292)
ES965_RS03930	COG0670	Belongs to the BI1 family
ES965_RS03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES965_RS03955	COG2124	cytochrome p450
ES965_RS03955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_RS03970	COG1368	sulfuric ester hydrolase activity
ES965_RS03975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES965_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_RS03985	COG1442	glycosyl transferase family 8
ES965_RS03990	COG1216	Glycosyl transferase, family 2
ES965_RS03995	COG1442	glycosyl transferase family 8
ES965_RS04000	COG2223	nitrite transmembrane transporter activity
ES965_RS04010	COG0531	amino acid
ES965_RS04015	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS04020	COG0840	transmembrane signaling receptor activity
ES965_RS04025	COG0488	(ABC) transporter
ES965_RS04035	COG0789	Transcriptional regulator
ES965_RS04040	COG2814	Major facilitator Superfamily
ES965_RS04055	COG0488	(ABC) transporter
ES965_RS04060	COG0513	Belongs to the DEAD box helicase family
ES965_RS04065	COG0456	acetyltransferase
ES965_RS04070	COG2130	NADP-dependent
ES965_RS04075	COG1120	ATPase activity
ES965_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS04090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES965_RS04110	COG3866	Pectate lyase
ES965_RS04115	COG0471	metal ion transport
ES965_RS04120	COG3290	protein histidine kinase activity
ES965_RS04125	COG4565	transcriptional regulatory protein
ES965_RS04130	COG3181	Tripartite tricarboxylate transporter family receptor
ES965_RS04135	COG2851	Citrate transporter
ES965_RS04140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS04145	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES965_RS04150	COG1254	Belongs to the acylphosphatase family
ES965_RS04155	COG2258	MOSC domain
ES965_RS04175	COG0024	Methionine aminopeptidase
ES965_RS04180	COG1263	PTS System
ES965_RS04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS04185	COG1368	sulfuric ester hydrolase activity
ES965_RS04200	COG1115	amino acid carrier protein
ES965_RS04215	COG0697	spore germination
ES965_RS04220	COG1263	PTS System
ES965_RS04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS04225	COG0366	Alpha amylase catalytic
ES965_RS04230	COG2188	Transcriptional regulator
ES965_RS04235	COG0778	Nitroreductase
ES965_RS04240	COG0737	Belongs to the 5'-nucleotidase family
ES965_RS04245	COG0693	protein deglycase activity
ES965_RS04250	COG2814	Major facilitator Superfamily
ES965_RS04255	COG4840	Belongs to the UPF0435 family
ES965_RS04260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES965_RS04265	COG4980	gas vesicle protein
ES965_RS04270	COG1295	ribonuclease BN
ES965_RS04275	COG0477	Major facilitator Superfamily
ES965_RS04280	COG0387	Pfam Sodium calcium exchanger
ES965_RS04290	COG0668	transmembrane transport
ES965_RS04295	COG0535	radical SAM domain protein
ES965_RS04305	COG0726	polysaccharide deacetylase
ES965_RS04310	COG2084	Dehydrogenase
ES965_RS04315	COG0598	Magnesium transport protein CorA
ES965_RS04320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES965_RS04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES965_RS04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES965_RS04345	COG4637	Psort location Cytoplasmic, score
ES965_RS04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_RS04360	COG0022	dehydrogenase e1 component
ES965_RS04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_RS04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_RS04375	COG3284	Transcriptional regulator
ES965_RS04385	COG1742	UPF0060 membrane protein
ES965_RS04405	COG4842	Belongs to the WXG100 family
ES965_RS04410	COG1486	melibiose metabolic process
ES965_RS04415	COG1737	Transcriptional regulator
ES965_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS04420	COG1263	PTS System
ES965_RS04425	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_RS04430	COG1132	(ABC) transporter
ES965_RS04435	COG1132	(ABC) transporter
ES965_RS04440	COG2259	Doxx family
ES965_RS04445	COG2514	catechol 2,3-dioxygenase activity
ES965_RS04450	COG4977	sequence-specific DNA binding
ES965_RS04450	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS04460	COG1082	Xylose isomerase domain protein TIM barrel
ES965_RS04465	COG0673	inositol 2-dehydrogenase activity
ES965_RS04470	COG4585	Histidine kinase
ES965_RS04475	COG2197	response regulator
ES965_RS04480	COG1131	(ABC) transporter
ES965_RS04485	COG1511	domain protein
ES965_RS04485	COG0842	Transport permease protein
ES965_RS04490	COG0842	Transport permease protein
ES965_RS04500	COG1695	Transcriptional regulator
ES965_RS04505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES965_RS04510	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES965_RS04515	COG1309	transcriptional regulator
ES965_RS04520	COG2814	Major facilitator Superfamily
ES965_RS04525	COG2318	DinB family
ES965_RS04530	COG2814	Major facilitator Superfamily
ES965_RS04535	COG1846	Transcriptional regulator
ES965_RS04540	COG0392	lysyltransferase activity
ES965_RS04540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES965_RS04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS04560	COG0384	phenazine biosynthesis protein PhzF
ES965_RS04565	COG0778	Nitroreductase
ES965_RS04580	COG1090	epimerase
ES965_RS04585	COG2137	regulation of response to DNA damage stimulus
ES965_RS04600	COG2814	Major facilitator Superfamily
ES965_RS04615	COG3103	Sh3 type 3 domain protein
ES965_RS04620	COG5658	integral membrane protein
ES965_RS04625	COG0596	Alpha beta hydrolase
ES965_RS04630	COG0463	Glycosyl transferase, family 2
ES965_RS04635	COG4485	Bacterial membrane protein, YfhO
ES965_RS04640	COG1988	membrane-bound metal-dependent
ES965_RS04645	COG1194	a g-specific adenine glycosylase
ES965_RS04655	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS04670	COG3557	Belongs to the UPF0374 family
ES965_RS04675	COG1132	(ABC) transporter
ES965_RS04680	COG4129	membrane
ES965_RS04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES965_RS04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES965_RS04695	COG0735	belongs to the Fur family
ES965_RS04805	COG4326	sporulation control protein
ES965_RS04815	COG5577	PFAM Coat F domain
ES965_RS04820	COG3340	Belongs to the peptidase S51 family
ES965_RS04825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES965_RS04830	COG0277	FAD linked oxidase domain protein
ES965_RS04840	COG0753	catalase activity
ES965_RS04845	COG1116	anion transmembrane transporter activity
ES965_RS04850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES965_RS04855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES965_RS04860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS04870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES965_RS04880	COG1476	TRANSCRIPTIONal
ES965_RS04890	COG3382	B3 4 domain protein
ES965_RS04895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES965_RS04905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES965_RS04910	COG0789	Transcriptional regulator
ES965_RS04915	COG1664	Polymer-forming cytoskeletal
ES965_RS04920	COG1664	Polymer-forming cytoskeletal
ES965_RS04925	COG2766	serine protein kinase
ES965_RS04930	COG2718	Belongs to the UPF0229 family
ES965_RS04935	COG1846	Transcriptional regulator
ES965_RS04940	COG1566	PFAM secretion protein HlyD family protein
ES965_RS04945	COG2814	Major facilitator Superfamily
ES965_RS04950	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES965_RS04970	COG1725	Transcriptional regulator
ES965_RS04975	COG1131	(ABC) transporter
ES965_RS04980	COG1131	(ABC) transporter
ES965_RS04985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_RS04990	COG1278	Cold shock
ES965_RS05000	COG1464	Belongs to the NlpA lipoprotein family
ES965_RS05005	COG3706	GGDEF domain
ES965_RS05010	COG1823	symporter activity
ES965_RS05030	COG5577	PFAM Coat F domain
ES965_RS05035	COG4085	toxin activity
ES965_RS05035	COG1525	nuclease
ES965_RS05035	COG0737	Belongs to the 5'-nucleotidase family
ES965_RS05040	COG3764	Sortase (surface protein transpeptidase)
ES965_RS05045	COG0564	pseudouridine synthase activity
ES965_RS05055	COG0517	IMP dehydrogenase activity
ES965_RS05060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES965_RS05065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES965_RS05065	COG3153	acetyltransferase
ES965_RS05070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_RS05075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES965_RS05080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES965_RS05085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES965_RS05090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES965_RS05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES965_RS05100	COG2203	Gaf domain
ES965_RS05100	COG4585	Histidine kinase
ES965_RS05105	COG2197	response regulator
ES965_RS05110	COG0431	NADPH-dependent FMN reductase
ES965_RS05125	COG0791	NLP P60 protein
ES965_RS05125	COG1388	LysM domain
ES965_RS05130	COG1959	2 iron, 2 sulfur cluster binding
ES965_RS05135	COG0668	transmembrane transport
ES965_RS05140	COG2719	SpoVR family
ES965_RS05145	COG1785	Belongs to the alkaline phosphatase family
ES965_RS05150	COG0791	NLP P60 protein
ES965_RS05150	COG1388	LysM domain
ES965_RS05155	COG0583	DNA-binding transcription factor activity
ES965_RS05160	COG0372	Belongs to the citrate synthase family
ES965_RS05165	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS05170	COG0531	amino acid
ES965_RS05175	COG0733	neurotransmitter:sodium symporter activity
ES965_RS05180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS05185	COG0456	acetyltransferase
ES965_RS05200	COG1595	DNA-templated transcription, initiation
ES965_RS05205	COG0667	Aldo Keto reductase
ES965_RS05210	COG0204	Acyl-transferase
ES965_RS05215	COG1253	flavin adenine dinucleotide binding
ES965_RS05220	COG0789	Transcriptional regulator
ES965_RS05225	COG0436	Aminotransferase
ES965_RS05230	COG1253	flavin adenine dinucleotide binding
ES965_RS05235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES965_RS05240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES965_RS05245	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_RS05255	COG0668	transmembrane transport
ES965_RS05260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES965_RS05265	COG0726	polysaccharide deacetylase
ES965_RS05270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_RS05275	COG1757	Na H antiporter
ES965_RS05280	COG0589	response to stress
ES965_RS05290	COG1132	(ABC) transporter
ES965_RS05295	COG1132	(ABC) transporter
ES965_RS05300	COG0702	epimerase
ES965_RS05320	COG0189	ligase activity
ES965_RS05325	COG0189	ligase activity
ES965_RS05330	COG4399	Belongs to the UPF0754 family
ES965_RS05335	COG3679	Belongs to the UPF0342 family
ES965_RS05340	COG4335	DNA alkylation repair
ES965_RS05345	COG0561	phosphatase activity
ES965_RS05350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES965_RS05355	COG0475	glutathione-regulated potassium exporter activity
ES965_RS05360	COG0490	domain, Protein
ES965_RS05370	COG1024	Enoyl-CoA hydratase
ES965_RS05380	COG4152	abc transporter atp-binding protein
ES965_RS05385	COG1668	transmembrane transport
ES965_RS05390	COG0420	3'-5' exonuclease activity
ES965_RS05395	COG4717	serine-type aminopeptidase activity
ES965_RS05400	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES965_RS05410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES965_RS05440	COG1846	Transcriptional regulator
ES965_RS05445	COG4980	gas vesicle protein
ES965_RS05460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES965_RS05465	COG0537	adenosine 5'-monophosphoramidase activity
ES965_RS05470	COG1131	(ABC) transporter
ES965_RS05475	COG4473	ABC transporter
ES965_RS05485	COG1473	amidohydrolase
ES965_RS05490	COG3069	C4-dicarboxylate transmembrane transporter activity
ES965_RS05500	COG2329	Antibiotic biosynthesis monooxygenase
ES965_RS05505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_RS05510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES965_RS05515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ES965_RS05520	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ES965_RS05525	COG1309	transcriptional regulator
ES965_RS05530	COG1511	domain protein
ES965_RS05535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_RS05540	COG4377	Putative membrane peptidase family (DUF2324)
ES965_RS05550	COG1363	Peptidase, m42
ES965_RS05555	COG4405	Protein conserved in bacteria
ES965_RS05560	COG1301	dicarboxylic acid transport
ES965_RS05570	COG1234	tRNA 3'-trailer cleavage
ES965_RS05575	COG0095	Lipoate-protein ligase
ES965_RS05580	COG0702	epimerase
ES965_RS05585	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS05595	COG0501	Belongs to the peptidase M48B family
ES965_RS05600	COG1404	Belongs to the peptidase S8 family
ES965_RS05605	COG0456	acetyltransferase
ES965_RS05610	COG0604	alcohol dehydrogenase
ES965_RS05615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES965_RS05620	COG0406	alpha-ribazole phosphatase activity
ES965_RS05625	COG0183	Belongs to the thiolase family
ES965_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS05635	COG1268	BioY protein
ES965_RS05640	COG0840	transmembrane signaling receptor activity
ES965_RS05645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_RS05645	COG0723	plastoquinol--plastocyanin reductase activity
ES965_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS05660	COG4903	ComK protein
ES965_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS05675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_RS05690	COG0398	Pfam SNARE associated Golgi protein
ES965_RS05695	COG0681	Belongs to the peptidase S26 family
ES965_RS05700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES965_RS05705	COG1846	Transcriptional regulator
ES965_RS05715	COG0738	Major facilitator superfamily
ES965_RS05720	COG0673	inositol 2-dehydrogenase activity
ES965_RS05725	COG0561	phosphatase activity
ES965_RS05730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_RS05735	COG1609	Transcriptional regulator
ES965_RS05740	COG3180	Ammonia monooxygenase
ES965_RS05745	COG0477	Major facilitator Superfamily
ES965_RS05745	COG2814	Major facilitator Superfamily
ES965_RS05750	COG4533	DNA binding
ES965_RS05760	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES965_RS05765	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES965_RS05770	COG1074	ATP-dependent DNA helicase activity
ES965_RS05775	COG0420	3'-5' exonuclease activity
ES965_RS05780	COG0419	ATPase involved in DNA repair
ES965_RS05785	COG1403	HNH endonuclease
ES965_RS05825	COG5337	Spore coat protein CotH
ES965_RS05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES965_RS05840	COG1404	Belongs to the peptidase S8 family
ES965_RS05850	COG0367	asparagine synthase
ES965_RS05855	COG1562	ergosterol biosynthetic process
ES965_RS05860	COG0534	Mate efflux family protein
ES965_RS05865	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS05865	COG2207	Transcriptional regulator
ES965_RS05870	COG1609	Transcriptional regulator
ES965_RS05875	COG0673	inositol 2-dehydrogenase activity
ES965_RS05880	COG2318	DinB family
ES965_RS05885	COG1279	arginine transmembrane transporter activity
ES965_RS05890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_RS05895	COG1357	PFAM Pentapeptide repeats (8 copies)
ES965_RS05900	COG2267	carboxylic ester hydrolase activity
ES965_RS05905	COG0529	Catalyzes the synthesis of activated sulfate
ES965_RS05910	COG2046	Belongs to the sulfate adenylyltransferase family
ES965_RS05915	COG0175	sulfate reduction
ES965_RS05920	COG2045	Belongs to the ComB family
ES965_RS05925	COG1809	phosphosulfolactate synthase activity
ES965_RS05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS05935	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_RS05940	COG2814	Major facilitator Superfamily
ES965_RS05945	COG0454	-acetyltransferase
ES965_RS05950	COG2153	protein acetylation
ES965_RS05955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES965_RS05955	COG0646	methionine synthase
ES965_RS05960	COG1666	GTP binding
ES965_RS05965	COG2996	Protein conserved in bacteria
ES965_RS05985	COG1695	Transcriptional regulator
ES965_RS06000	COG3227	Zinc metalloprotease (Elastase)
ES965_RS06005	COG1307	EDD domain protein, DegV family
ES965_RS06010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS06025	COG0561	phosphatase activity
ES965_RS06030	COG1073	alpha beta
ES965_RS06035	COG2151	metal-sulfur cluster biosynthetic enzyme
ES965_RS06045	COG0277	FAD linked oxidase domain protein
ES965_RS06050	COG2271	Major facilitator Superfamily
ES965_RS06055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES965_RS06060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ES965_RS06070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES965_RS06075	COG0505	Belongs to the CarA family
ES965_RS06080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES965_RS06085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES965_RS06100	COG2267	carboxylic ester hydrolase activity
ES965_RS06110	COG1744	ABC transporter substrate-binding protein PnrA-like
ES965_RS06125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_RS06130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES965_RS06135	COG5504	Zn-dependent protease
ES965_RS06140	COG0444	Belongs to the ABC transporter superfamily
ES965_RS06145	COG4608	Belongs to the ABC transporter superfamily
ES965_RS06155	COG0601	transmembrane transport
ES965_RS06160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_RS06170	COG0180	Tryptophanyl-tRNA synthetase
ES965_RS06175	COG4166	transmembrane transport
ES965_RS06180	COG0601	transmembrane transport
ES965_RS06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_RS06190	COG0444	Belongs to the ABC transporter superfamily
ES965_RS06195	COG4608	Belongs to the ABC transporter superfamily
ES965_RS06200	COG2814	Major facilitator Superfamily
ES965_RS06205	COG0456	acetyltransferase
ES965_RS06210	COG1393	Belongs to the ArsC family
ES965_RS06215	COG0861	Integral membrane protein TerC family
ES965_RS06225	COG4862	establishment of competence for transformation
ES965_RS06235	COG4469	Competence protein
ES965_RS06240	COG1164	Oligoendopeptidase f
ES965_RS06255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES965_RS06260	COG2346	COG2346, Truncated hemoglobins
ES965_RS06265	COG0741	lytic transglycosylase activity
ES965_RS06270	COG4116	CYTH
ES965_RS06280	COG2357	RelA SpoT domain protein
ES965_RS06285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES965_RS06290	COG0564	pseudouridine synthase activity
ES965_RS06295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES965_RS06300	COG0475	glutathione-regulated potassium exporter activity
ES965_RS06300	COG0569	domain protein
ES965_RS06305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES965_RS06310	COG0352	thiamine-phosphate diphosphorylase activity
ES965_RS06315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_RS06320	COG2104	thiamine diphosphate biosynthetic process
ES965_RS06325	COG2022	thiamine diphosphate biosynthetic process
ES965_RS06330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES965_RS06335	COG0351	phosphomethylpyrimidine kinase
ES965_RS06340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES965_RS06395	COG0210	DNA helicase
ES965_RS06425	COG2153	protein acetylation
ES965_RS06430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES965_RS06435	COG2382	esterase
ES965_RS06440	COG0626	cystathionine gamma-synthase activity
ES965_RS06445	COG0626	cystathionine gamma-synthase activity
ES965_RS06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS06455	COG5505	Protein of unknown function (DUF819)
ES965_RS06480	COG2815	serine threonine protein kinase
ES965_RS06480	COG0515	serine threonine protein kinase
ES965_RS06490	COG0457	Tetratricopeptide repeat
ES965_RS06495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES965_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS06510	COG3711	transcriptional antiterminator
ES965_RS06510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS06515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS06515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_RS06515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_RS06520	COG1482	cell wall glycoprotein biosynthetic process
ES965_RS06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS06540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES965_RS06560	COG0109	protoheme IX farnesyltransferase activity
ES965_RS06570	COG0726	polysaccharide deacetylase
ES965_RS06585	COG5504	Zn-dependent protease
ES965_RS06590	COG2205	protein histidine kinase activity
ES965_RS06600	COG3383	formate dehydrogenase (NAD+) activity
ES965_RS06605	COG2427	Protein of unknown function (DUF1641)
ES965_RS06615	COG1051	belongs to the nudix hydrolase family
ES965_RS06625	COG2124	cytochrome p450
ES965_RS06630	COG1819	glycosyl
ES965_RS06640	COG1587	Uroporphyrinogen-III synthase
ES965_RS06645	COG0390	transport system, permease component
ES965_RS06650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_RS06660	COG4297	protein containing double-stranded beta helix domain
ES965_RS06670	COG1252	NADH dehydrogenase
ES965_RS06675	COG1904	glucuronate isomerase
ES965_RS06680	COG2211	Major facilitator Superfamily
ES965_RS06685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES965_RS06690	COG1063	alcohol dehydrogenase
ES965_RS06695	COG1312	Catalyzes the dehydration of D-mannonate
ES965_RS06700	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS06705	COG2271	Major facilitator Superfamily
ES965_RS06710	COG1609	Transcriptional regulator
ES965_RS06715	COG0246	Mannitol dehydrogenase
ES965_RS06720	COG2721	sulfolactate sulfo-lyase activity
ES965_RS06725	COG0730	response to heat
ES965_RS06730	COG2318	DinB family
ES965_RS06735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES965_RS06740	COG0457	Tetratricopeptide repeat
ES965_RS06750	COG2350	Protein conserved in bacteria
ES965_RS06755	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS06755	COG1388	LysM domain
ES965_RS06755	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_RS06765	COG4195	phage-related replication protein
ES965_RS06770	COG3546	catalase activity
ES965_RS06775	COG2856	Zn peptidase
ES965_RS06780	COG1396	sequence-specific DNA binding
ES965_RS06790	COG1522	sequence-specific DNA binding
ES965_RS06795	COG1484	DNA-dependent DNA replication
ES965_RS06815	COG1595	DNA-templated transcription, initiation
ES965_RS06820	COG3728	DNA packaging
ES965_RS06820	COG5484	DNA packaging
ES965_RS06825	COG1783	phage Terminase large subunit
ES965_RS06830	COG5518	Phage portal protein
ES965_RS06835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES965_RS06840	COG4653	Phage capsid family
ES965_RS06890	COG3953	SLT domain
ES965_RS06890	COG3953	SLT domain
ES965_RS06890	COG5412	phage tail tape measure protein
ES965_RS06890	COG5412	phage tail tape measure protein
ES965_RS06895	COG1652	LysM domain
ES965_RS06900	COG4193	domain, Protein
ES965_RS06910	COG3628	GPW Gp25 family protein
ES965_RS06915	COG3299	homolog of phage Mu protein gp47
ES965_RS06920	COG3778	Protein conserved in bacteria
ES965_RS06960	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_RS06960	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS06980	COG0306	phosphate transporter
ES965_RS06985	COG1392	Phosphate transport regulator
ES965_RS06990	COG0531	amino acid
ES965_RS06995	COG0346	lactoylglutathione lyase activity
ES965_RS07005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES965_RS07010	COG0463	Glycosyl transferase, family 2
ES965_RS07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_RS07020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_RS07025	COG2362	D-Aminopeptidase
ES965_RS07030	COG0601	transmembrane transport
ES965_RS07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_RS07040	COG0444	Belongs to the ABC transporter superfamily
ES965_RS07045	COG4166	transmembrane transport
ES965_RS07050	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES965_RS07055	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_RS07060	COG0791	NLP P60 protein
ES965_RS07065	COG4608	Belongs to the ABC transporter superfamily
ES965_RS07070	COG2706	6-phosphogluconolactonase activity
ES965_RS07075	COG1834	amidinotransferase
ES965_RS07080	COG1607	acyl-coa hydrolase
ES965_RS07085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES965_RS07085	COG1017	nitric oxide dioxygenase activity
ES965_RS07095	COG2323	membrane
ES965_RS07100	COG2318	DinB family
ES965_RS07105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS07110	COG2076	Multidrug Resistance protein
ES965_RS07115	COG2076	Multidrug Resistance protein
ES965_RS07120	COG0788	formyltetrahydrofolate deformylase activity
ES965_RS07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES965_RS07130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES965_RS07135	COG1764	response to oxidative stress
ES965_RS07140	COG1846	Transcriptional regulator
ES965_RS07145	COG1764	response to oxidative stress
ES965_RS07150	COG0590	tRNA wobble adenosine to inosine editing
ES965_RS07155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_RS07160	COG1404	Belongs to the peptidase S8 family
ES965_RS07165	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS07170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES965_RS07175	COG1122	ATPase activity
ES965_RS07180	COG4721	ABC-type cobalt transport system, permease component
ES965_RS07190	COG0745	RESPONSE REGULATOR receiver
ES965_RS07195	COG3850	Histidine kinase
ES965_RS07195	COG5002	protein histidine kinase activity
ES965_RS07200	COG3212	peptidase
ES965_RS07205	COG3212	peptidase
ES965_RS07220	COG2239	Acts as a magnesium transporter
ES965_RS07225	COG0789	Transcriptional regulator
ES965_RS07240	COG1846	Transcriptional regulator
ES965_RS07245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_RS07250	COG0726	polysaccharide deacetylase
ES965_RS07255	COG1408	metallophosphoesterase
ES965_RS07265	COG0463	Glycosyl transferase, family 2
ES965_RS07270	COG1793	dna ligase
ES965_RS07270	COG3285	dna ligase
ES965_RS07275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES965_RS07280	COG3300	MHYT domain
ES965_RS07280	COG5001	Diguanylate cyclase
ES965_RS07285	COG0586	Pfam SNARE associated Golgi protein
ES965_RS07290	COG0861	Integral membrane protein TerC family
ES965_RS07295	COG1191	sigma factor activity
ES965_RS07315	COG0501	Belongs to the peptidase M48B family
ES965_RS07320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES965_RS07335	COG3594	Acyltransferase
ES965_RS07340	COG5002	protein histidine kinase activity
ES965_RS07345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES965_RS07355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES965_RS07360	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES965_RS07365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES965_RS07370	COG0436	Aminotransferase
ES965_RS07375	COG1850	ribulose-bisphosphate carboxylase activity
ES965_RS07380	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES965_RS07385	COG0235	Class ii aldolase
ES965_RS07390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES965_RS07395	COG3339	Conserved Protein
ES965_RS07410	COG3852	Histidine kinase
ES965_RS07415	COG1846	Transcriptional regulator
ES965_RS07420	COG1360	Flagellar Motor Protein
ES965_RS07425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES965_RS07435	COG0542	response to heat
ES965_RS07440	COG3949	Membrane
ES965_RS07445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES965_RS07450	COG0720	synthase
ES965_RS07455	COG0602	queuosine metabolic process
ES965_RS07460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES965_RS07465	COG1733	regulation of RNA biosynthetic process
ES965_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS07475	COG1388	LysM domain
ES965_RS07475	COG4641	Protein conserved in bacteria
ES965_RS07480	COG1388	LysM domain
ES965_RS07485	COG3858	chitin binding
ES965_RS07495	COG4873	Protein conserved in bacteria
ES965_RS07505	COG3773	Cell wall hydrolase
ES965_RS07510	COG2244	polysaccharide biosynthetic process
ES965_RS07515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS07520	COG2217	Heavy metal translocating P-type atpase
ES965_RS07530	COG0006	proline dipeptidase activity
ES965_RS07535	COG1609	Transcriptional regulator
ES965_RS07540	COG3711	transcriptional antiterminator
ES965_RS07545	COG2190	(PTS) system
ES965_RS07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS07545	COG1263	PTS System
ES965_RS07550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS07555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES965_RS07565	COG1533	DNA photolyase activity
ES965_RS07570	COG0456	acetyltransferase
ES965_RS07575	COG0840	transmembrane signaling receptor activity
ES965_RS07580	COG2084	Dehydrogenase
ES965_RS07585	COG4257	antibiotic catabolic process
ES965_RS07590	COG2340	Cysteine-rich secretory protein family
ES965_RS07595	COG0768	penicillin binding
ES965_RS07600	COG4191	Histidine kinase
ES965_RS07605	COG0436	Aminotransferase
ES965_RS07615	COG0784	Response regulator, receiver
ES965_RS07615	COG0835	chemotaxis
ES965_RS07625	COG2814	Major facilitator Superfamily
ES965_RS07630	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_RS07635	COG1408	metallophosphoesterase
ES965_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS07645	COG2200	EAL domain
ES965_RS07650	COG4703	Protein of unknown function (DUF1797)
ES965_RS07655	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES965_RS07665	COG0517	IMP dehydrogenase activity
ES965_RS07670	COG0583	DNA-binding transcription factor activity
ES965_RS07675	COG0716	FMN binding
ES965_RS07685	COG0716	FMN binding
ES965_RS07690	COG2171	N-acyltransferase activity
ES965_RS07695	COG1473	amidohydrolase
ES965_RS07705	COG0668	transmembrane transport
ES965_RS07710	COG0450	alkyl hydroperoxide reductase
ES965_RS07715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS07730	COG0746	molybdenum cofactor guanylyltransferase activity
ES965_RS07735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES965_RS07740	COG0303	'Molybdopterin
ES965_RS07745	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES965_RS07750	COG0314	molybdopterin synthase activity
ES965_RS07755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES965_RS07760	COG1132	(ABC) transporter
ES965_RS07765	COG1132	(ABC) transporter
ES965_RS07775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES965_RS07780	COG1136	(ABC) transporter
ES965_RS07785	COG0577	efflux transmembrane transporter activity
ES965_RS07790	COG1349	DNA-binding transcription factor activity
ES965_RS07795	COG1105	Belongs to the carbohydrate kinase PfkB family
ES965_RS07800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS07800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_RS07800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_RS07805	COG0681	Belongs to the peptidase S26 family
ES965_RS07815	COG0488	(ABC) transporter
ES965_RS07820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES965_RS07825	COG2309	aminopeptidase activity
ES965_RS07835	COG1077	Cell shape determining protein MreB Mrl
ES965_RS07840	COG2002	toxin-antitoxin pair type II binding
ES965_RS07845	COG3852	Histidine kinase
ES965_RS07850	COG2105	PFAM AIG2 family protein
ES965_RS07850	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES965_RS07855	COG0569	domain protein
ES965_RS07860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES965_RS07865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES965_RS07870	COG5503	Protein of unknown function (DUF1447)
ES965_RS07875	COG0561	phosphatase activity
ES965_RS07880	COG0242	peptide deformylase activity
ES965_RS07890	COG0497	DNA recombination
ES965_RS07895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_RS07900	COG0022	dehydrogenase e1 component
ES965_RS07905	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_RS07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_RS07915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS07925	COG1982	Orn Lys Arg decarboxylase major
ES965_RS07930	COG4476	Belongs to the UPF0223 family
ES965_RS07935	COG4493	Belongs to the UPF0637 family
ES965_RS07945	COG0483	inositol monophosphate 1-phosphatase activity
ES965_RS07955	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES965_RS07975	COG1595	DNA-templated transcription, initiation
ES965_RS07995	COG1217	gtp-binding protein TYPA
ES965_RS08005	COG4896	Protein conserved in bacteria
ES965_RS08015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES965_RS08020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES965_RS08025	COG2066	Belongs to the glutaminase family
ES965_RS08030	COG4838	Belongs to the UPF0358 family
ES965_RS08035	COG0772	Belongs to the SEDS family
ES965_RS08040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES965_RS08045	COG1612	heme a metabolic process
ES965_RS08050	COG0109	protoheme IX farnesyltransferase activity
ES965_RS08055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES965_RS08055	COG2010	Cytochrome c
ES965_RS08060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES965_RS08065	COG1845	cytochrome c oxidase, subunit III
ES965_RS08070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES965_RS08075	COG3336	cytochrome c oxidase
ES965_RS08085	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES965_RS08090	COG2340	Cysteine-rich secretory protein family
ES965_RS08105	COG3679	Belongs to the UPF0342 family
ES965_RS08110	COG4471	UPF0298 protein
ES965_RS08115	COG0742	ribosomal rna small subunit methyltransferase
ES965_RS08120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES965_RS08125	COG3314	Sporulation integral membrane protein YlbJ
ES965_RS08130	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES965_RS08135	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES965_RS08140	COG1323	Belongs to the UPF0348 family
ES965_RS08150	COG1399	metal-binding, possibly nucleic acid-binding protein
ES965_RS08165	COG0454	-acetyltransferase
ES965_RS08170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES965_RS08175	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES965_RS08180	COG2001	Belongs to the MraZ family
ES965_RS08185	COG0275	rRNA processing
ES965_RS08190	COG4839	cell division protein FtsL
ES965_RS08195	COG0768	penicillin binding
ES965_RS08200	COG0768	penicillin binding
ES965_RS08205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES965_RS08210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES965_RS08215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES965_RS08220	COG0772	Belongs to the SEDS family
ES965_RS08225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_RS08230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES965_RS08235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES965_RS08240	COG3879	Bacterial protein of unknown function (DUF881)
ES965_RS08245	COG3879	Bacterial protein of unknown function (DUF881)
ES965_RS08250	COG3856	small basic protein
ES965_RS08255	COG0849	cell division
ES965_RS08260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES965_RS08265	COG4412	M6 family metalloprotease domain protein
ES965_RS08265	COG1404	Belongs to the peptidase S8 family
ES965_RS08275	COG1191	sigma factor activity
ES965_RS08280	COG1191	sigma factor activity
ES965_RS08285	COG1119	ATPase activity
ES965_RS08290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_RS08295	COG1873	PFAM PRC-barrel domain
ES965_RS08300	COG1496	oxidoreductase activity
ES965_RS08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES965_RS08310	COG1799	cell septum assembly
ES965_RS08315	COG0762	integral membrane protein
ES965_RS08320	COG2302	S4 RNA-binding domain
ES965_RS08325	COG3599	regulation of cell shape
ES965_RS08330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES965_RS08335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_RS08340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES965_RS08345	COG0564	pseudouridine synthase activity
ES965_RS08350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES965_RS08355	COG2233	PERMEase
ES965_RS08360	COG0540	Belongs to the ATCase OTCase family
ES965_RS08365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES965_RS08370	COG0505	Belongs to the CarA family
ES965_RS08375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES965_RS08380	COG0543	2 iron, 2 sulfur cluster binding
ES965_RS08385	COG0167	dihydroorotate dehydrogenase activity
ES965_RS08390	COG0284	orotidine-5'-phosphate decarboxylase activity
ES965_RS08395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES965_RS08400	COG0175	sulfate reduction
ES965_RS08405	COG0306	phosphate transporter
ES965_RS08410	COG2046	Belongs to the sulfate adenylyltransferase family
ES965_RS08415	COG0529	Catalyzes the synthesis of activated sulfate
ES965_RS08420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES965_RS08425	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES965_RS08430	COG1648	precorrin-2 dehydrogenase activity
ES965_RS08435	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ES965_RS08440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES965_RS08445	COG1561	YicC-like family, N-terminal region
ES965_RS08455	COG0194	GDP metabolic process
ES965_RS08460	COG1758	RNA polymerase activity
ES965_RS08465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES965_RS08470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES965_RS08475	COG0242	peptide deformylase activity
ES965_RS08480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES965_RS08485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES965_RS08485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES965_RS08490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES965_RS08495	COG0631	protein serine/threonine phosphatase activity
ES965_RS08500	COG2815	serine threonine protein kinase
ES965_RS08500	COG0515	serine threonine protein kinase
ES965_RS08505	COG1162	GTPase activity
ES965_RS08510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES965_RS08515	COG1564	THIamine pyrophosphokinase
ES965_RS08525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES965_RS08530	COG1302	Protein conserved in bacteria
ES965_RS08535	COG1461	Dihydroxyacetone kinase
ES965_RS08540	COG1760	l-serine dehydratase
ES965_RS08545	COG1760	l-serine dehydratase
ES965_RS08550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES965_RS08555	COG1349	DNA-binding transcription factor activity
ES965_RS08555	COG2050	protein possibly involved in aromatic compounds catabolism
ES965_RS08560	COG0416	fatty acid biosynthetic process
ES965_RS08565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS08580	COG0571	ribonuclease III activity
ES965_RS08585	COG1196	nuclear chromosome segregation
ES965_RS08590	COG0552	protein localization to endoplasmic reticulum
ES965_RS08600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES965_RS08605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES965_RS08610	COG0228	four-way junction DNA binding
ES965_RS08615	COG1837	Belongs to the UPF0109 family
ES965_RS08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES965_RS08630	COG0336	Belongs to the RNA methyltransferase TrmD family
ES965_RS08635	COG0335	large ribosomal subunit rRNA binding
ES965_RS08640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES965_RS08645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES965_RS08655	COG2257	FlhB HrpN YscU SpaS Family
ES965_RS08660	COG0045	succinate-CoA ligase (ADP-forming) activity
ES965_RS08665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES965_RS08670	COG0758	DNA mediated transformation
ES965_RS08675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES965_RS08680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES965_RS08685	COG4974	Belongs to the 'phage' integrase family
ES965_RS08690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES965_RS08695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES965_RS08700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES965_RS08705	COG1815	bacterial-type flagellum-dependent cell motility
ES965_RS08710	COG1558	bacterial-type flagellum-dependent cell motility
ES965_RS08715	COG1677	Flagellar hook-basal body complex protein FliE
ES965_RS08720	COG1766	The M ring may be actively involved in energy transduction
ES965_RS08725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_RS08730	COG1317	bacterial-type flagellum organization
ES965_RS08735	COG1157	protein secretion by the type III secretion system
ES965_RS08740	COG2882	bacterial-type flagellum organization
ES965_RS08745	COG3334	PFAM MgtE intracellular
ES965_RS08750	COG3144	bacterial-type flagellum assembly
ES965_RS08755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES965_RS08760	COG4786	Flagellar basal body rod
ES965_RS08765	COG1582	Flagellar protein (FlbD)
ES965_RS08770	COG1580	Controls the rotational direction of flagella during chemotaxis
ES965_RS08775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_RS08780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_RS08780	COG1776	CheC inhibitor of MCP methylation
ES965_RS08785	COG2201	protein-glutamate methylesterase activity
ES965_RS08790	COG3190	flagellar
ES965_RS08795	COG1338	Plays a role in the flagellum-specific transport system
ES965_RS08800	COG1987	bacterial-type flagellum assembly
ES965_RS08805	COG1684	flagellar biosynthetic protein fliR
ES965_RS08810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES965_RS08815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES965_RS08820	COG1419	protein localization to endoplasmic reticulum
ES965_RS08825	COG0455	bacterial-type flagellum organization
ES965_RS08830	COG2201	protein-glutamate methylesterase activity
ES965_RS08835	COG2198	Histidine kinase
ES965_RS08835	COG0643	Histidine kinase
ES965_RS08840	COG0835	chemotaxis
ES965_RS08845	COG1776	CheC inhibitor of MCP methylation
ES965_RS08850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES965_RS08855	COG1191	sigma factor activity
ES965_RS08865	COG0052	Belongs to the universal ribosomal protein uS2 family
ES965_RS08870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES965_RS08875	COG0528	UMP kinase activity
ES965_RS08880	COG0233	cytoplasmic translational termination
ES965_RS08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES965_RS08890	COG4589	Belongs to the CDS family
ES965_RS08895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES965_RS08900	COG0750	zinc metalloprotease
ES965_RS08905	COG0442	prolyl-tRNA aminoacylation
ES965_RS08910	COG2176	DNA-directed DNA polymerase activity
ES965_RS08915	COG0779	Required for maturation of 30S ribosomal subunits
ES965_RS08920	COG0195	Participates in both transcription termination and antitermination
ES965_RS08925	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES965_RS08930	COG1358	cellular component organization or biogenesis
ES965_RS08935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES965_RS08940	COG1550	Protein conserved in bacteria
ES965_RS08945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES965_RS08950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES965_RS08955	COG0196	riboflavin kinase activity
ES965_RS08960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES965_RS08965	COG1185	polyribonucleotide nucleotidyltransferase activity
ES965_RS08970	COG0726	polysaccharide deacetylase
ES965_RS08975	COG0612	Peptidase, M16
ES965_RS08980	COG1873	PFAM PRC-barrel domain
ES965_RS08985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES965_RS08990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES965_RS08995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES965_RS09000	COG0527	aspartate kinase activity
ES965_RS09005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES965_RS09010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES965_RS09015	COG0740	serine-type endopeptidase activity
ES965_RS09025	COG4980	gas vesicle protein
ES965_RS09025	COG1674	ftsk spoiiie
ES965_RS09030	COG2188	Transcriptional regulator
ES965_RS09035	COG2814	Major facilitator Superfamily
ES965_RS09040	COG0612	Peptidase, M16
ES965_RS09045	COG0612	Peptidase, M16
ES965_RS09050	COG0300	oxidoreductase activity
ES965_RS09065	COG1426	Protein conserved in bacteria
ES965_RS09070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES965_RS09075	COG1058	Belongs to the CinA family
ES965_RS09075	COG1546	Belongs to the CinA family
ES965_RS09080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES965_RS09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_RS09090	COG1418	mRNA catabolic process
ES965_RS09095	COG1692	metallophosphoesterase
ES965_RS09100	COG2359	stage V sporulation protein S
ES965_RS09105	COG1063	alcohol dehydrogenase
ES965_RS09110	COG0156	8-amino-7-oxononanoate synthase activity
ES965_RS09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES965_RS09120	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES965_RS09130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES965_RS09135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES965_RS09150	COG3226	Transcriptional regulator
ES965_RS09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS09165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_RS09170	COG3321	synthase
ES965_RS09175	COG2070	2-Nitropropane dioxygenase
ES965_RS09175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_RS09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_RS09185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES965_RS09190	COG3425	synthase
ES965_RS09195	COG1024	Enoyl-CoA hydratase
ES965_RS09200	COG1024	Enoyl-CoA hydratase
ES965_RS09205	COG0300	oxidoreductase activity
ES965_RS09205	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS09205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS09205	COG3321	synthase
ES965_RS09210	COG3321	synthase
ES965_RS09210	COG0300	oxidoreductase activity
ES965_RS09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_RS09210	COG4221	oxidoreductase activity
ES965_RS09215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_RS09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS09215	COG3321	synthase
ES965_RS09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS09220	COG3321	synthase
ES965_RS09220	COG4221	oxidoreductase activity
ES965_RS09225	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES965_RS09225	COG3321	synthase
ES965_RS09225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ES965_RS09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_RS09230	COG2124	cytochrome p450
ES965_RS09240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS09245	COG1404	Belongs to the peptidase S8 family
ES965_RS09255	COG4195	phage-related replication protein
ES965_RS09260	COG1764	response to oxidative stress
ES965_RS09265	COG2076	Multidrug Resistance protein
ES965_RS09270	COG2076	Multidrug Resistance protein
ES965_RS09285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES965_RS09290	COG1923	regulation of RNA biosynthetic process
ES965_RS09305	COG1780	Probably involved in ribonucleotide reductase function
ES965_RS09310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_RS09315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_RS09320	COG4112	unkown
ES965_RS09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS09335	COG0464	growth
ES965_RS09340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES965_RS09345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES965_RS09350	COG0789	Transcriptional regulator
ES965_RS09355	COG0174	glutamine synthetase
ES965_RS09450	COG4282	regulation of fungal-type cell wall biogenesis
ES965_RS09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS09495	COG0135	phosphoribosylanthranilate isomerase activity
ES965_RS09500	COG2211	Major facilitator Superfamily
ES965_RS09505	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_RS09510	COG1940	carbohydrate kinase activity
ES965_RS09515	COG2115	Belongs to the xylose isomerase family
ES965_RS09520	COG1070	Carbohydrate kinase
ES965_RS09530	COG1525	nuclease
ES965_RS09535	COG2814	Major facilitator Superfamily
ES965_RS09540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES965_RS09555	COG0756	dUTP diphosphatase activity
ES965_RS09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_RS09605	COG3832	glyoxalase III activity
ES965_RS09620	COG0697	spore germination
ES965_RS09625	COG0531	amino acid
ES965_RS09655	COG4195	phage-related replication protein
ES965_RS09665	COG0346	lactoylglutathione lyase activity
ES965_RS09675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES965_RS09680	COG1388	LysM domain
ES965_RS09685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES965_RS09690	COG4224	UPF0291 protein
ES965_RS09695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES965_RS09705	COG3763	UPF0154 protein
ES965_RS09715	COG0785	Cytochrome C biogenesis protein
ES965_RS09720	COG2201	protein-glutamate methylesterase activity
ES965_RS09725	COG4846	Membrane protein involved in cytochrome C biogenesis
ES965_RS09735	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_RS09750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES965_RS09755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS09775	COG0824	Thioesterase
ES965_RS09785	COG4841	protein insertion into membrane
ES965_RS09790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES965_RS09795	COG1832	CoA-binding protein
ES965_RS09800	COG0187	DNA topoisomerase II activity
ES965_RS09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES965_RS09815	COG1115	amino acid carrier protein
ES965_RS09820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES965_RS09830	COG5520	Belongs to the glycosyl hydrolase 30 family
ES965_RS09835	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_RS09840	COG2246	polysaccharide biosynthetic process
ES965_RS09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_RS09850	COG0586	Pfam SNARE associated Golgi protein
ES965_RS09855	COG2404	hydrolase activity, acting on ester bonds
ES965_RS09860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES965_RS09865	COG1024	Enoyl-CoA hydratase
ES965_RS09870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES965_RS09875	COG0511	ligase activity, forming carbon-carbon bonds
ES965_RS09880	COG0439	Biotin carboxylase
ES965_RS09885	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS09890	COG1960	acyl-CoA dehydrogenase activity
ES965_RS09905	COG1649	PFAM Uncharacterised BCR, COG1649
ES965_RS09915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES965_RS09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS09940	COG2027	D-alanyl-D-alanine carboxypeptidase
ES965_RS09945	COG2017	converts alpha-aldose to the beta-anomer
ES965_RS09950	COG0534	Mate efflux family protein
ES965_RS09965	COG0582	viral genome integration into host DNA
ES965_RS09970	COG0166	Belongs to the GPI family
ES965_RS09975	COG0405	Gamma-glutamyltransferase
ES965_RS09980	COG0583	DNA-binding transcription factor activity
ES965_RS09985	COG0604	alcohol dehydrogenase
ES965_RS09990	COG0493	'glutamate synthase
ES965_RS09995	COG0070	glutamate synthase
ES965_RS09995	COG0069	glutamate synthase activity
ES965_RS09995	COG0067	glutamate synthase
ES965_RS10000	COG0583	DNA-binding transcription factor activity
ES965_RS10005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES965_RS10010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_RS10020	COG0300	oxidoreductase activity
ES965_RS10025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES965_RS10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_RS10040	COG2814	Major facilitator Superfamily
ES965_RS10045	COG1070	Carbohydrate kinase
ES965_RS10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES965_RS10055	COG0243	molybdopterin cofactor binding
ES965_RS10080	COG5278	phosphoserine phosphatase activity
ES965_RS10080	COG0840	transmembrane signaling receptor activity
ES965_RS10085	COG2368	4-hydroxyphenylacetate
ES965_RS10090	COG4305	rare lipoprotein A
ES965_RS10095	COG3619	membrane
ES965_RS10100	COG3866	Pectate lyase
ES965_RS10105	COG2135	peptidase activity
ES965_RS10115	COG2140	Oxalate decarboxylase
ES965_RS10140	COG2720	vancomycin resistance protein
ES965_RS10155	COG3739	integral membrane protein
ES965_RS10160	COG0583	DNA-binding transcription factor activity
ES965_RS10165	COG0697	spore germination
ES965_RS10175	COG0693	protein deglycase activity
ES965_RS10180	COG2367	Beta-lactamase
ES965_RS10205	COG0574	Belongs to the PEP-utilizing enzyme family
ES965_RS10205	COG3848	Pyruvate phosphate dikinase
ES965_RS10210	COG0726	polysaccharide deacetylase
ES965_RS10305	COG3655	Transcriptional regulator
ES965_RS10330	COG1404	Belongs to the peptidase S8 family
ES965_RS10360	COG0457	Tetratricopeptide repeat
ES965_RS10370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_RS10380	COG4282	regulation of fungal-type cell wall biogenesis
ES965_RS10385	COG1231	oxidoreductase activity
ES965_RS10390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_RS10395	COG0662	Cupin 2, conserved barrel domain protein
ES965_RS10395	COG2207	Transcriptional regulator
ES965_RS10400	COG0456	acetyltransferase
ES965_RS10405	COG1309	transcriptional regulator
ES965_RS10410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS10415	COG3708	Transcriptional regulator
ES965_RS10420	COG2378	regulation of single-species biofilm formation
ES965_RS10430	COG0640	Transcriptional regulator
ES965_RS10435	COG0741	lytic transglycosylase activity
ES965_RS10440	COG2322	membrane
ES965_RS10455	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES965_RS10460	COG3239	Fatty acid desaturase
ES965_RS10465	COG4585	Histidine kinase
ES965_RS10470	COG2197	response regulator
ES965_RS10475	COG1388	LysM domain
ES965_RS10475	COG3584	3D domain protein
ES965_RS10480	COG0514	ATP-dependent DNA helicase (RecQ)
ES965_RS10495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES965_RS10500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_RS10515	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS10545	COG1657	PFAM Prenyltransferase squalene oxidase
ES965_RS10550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES965_RS10555	COG0733	neurotransmitter:sodium symporter activity
ES965_RS10560	COG0385	Bile acid
ES965_RS10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_RS10570	COG0567	Dehydrogenase, E1 component
ES965_RS10575	COG4548	von Willebrand factor, type A
ES965_RS10580	COG0714	Associated with various cellular activities
ES965_RS10585	COG2032	superoxide dismutase activity
ES965_RS10590	COG1388	LysM domain
ES965_RS10590	COG0791	NLP P60 protein
ES965_RS10595	COG1819	glycosyl
ES965_RS10600	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES965_RS10605	COG0534	Mate efflux family protein
ES965_RS10610	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_RS10620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_RS10630	COG2962	Rard protein
ES965_RS10645	COG2610	gluconate transmembrane transporter activity
ES965_RS10650	COG1942	4-Oxalocrotonate Tautomerase
ES965_RS10655	COG1733	regulation of RNA biosynthetic process
ES965_RS10660	COG0778	Nitroreductase
ES965_RS10665	COG0400	carboxylic ester hydrolase activity
ES965_RS10670	COG0346	lactoylglutathione lyase activity
ES965_RS10680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_RS10685	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS10685	COG0793	Belongs to the peptidase S41A family
ES965_RS10690	COG2226	methyltransferase
ES965_RS10700	COG1876	peptidase activity
ES965_RS10705	COG0813	purine-nucleoside phosphorylase activity
ES965_RS10720	COG0671	phosphoesterase, PA-phosphatase related
ES965_RS10745	COG4479	Belongs to the UPF0346 family
ES965_RS10755	COG1509	lysine 2,3-aminomutase activity
ES965_RS10760	COG0456	acetyltransferase
ES965_RS10765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_RS10770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES965_RS10775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES965_RS10780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_RS10795	COG0456	acetyltransferase
ES965_RS10800	COG0463	Glycosyl transferase, family 2
ES965_RS10815	COG4641	Protein conserved in bacteria
ES965_RS10820	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES965_RS10825	COG1086	Polysaccharide biosynthesis protein
ES965_RS10830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES965_RS10835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES965_RS10840	COG1846	Transcriptional regulator
ES965_RS10845	COG0534	Mate efflux family protein
ES965_RS10855	COG4698	Protein conserved in bacteria
ES965_RS10860	COG2755	lipolytic protein G-D-S-L family
ES965_RS10865	COG1999	signal sequence binding
ES965_RS10875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES965_RS10880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES965_RS10885	COG1272	protein, Hemolysin III
ES965_RS10890	COG0204	Acyl-transferase
ES965_RS10895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES965_RS10900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ES965_RS10905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES965_RS10915	COG2521	methyltransferase
ES965_RS10915	COG2136	Putative SAM-dependent methyltransferase
ES965_RS10925	COG0129	dihydroxy-acid dehydratase activity
ES965_RS10930	COG1413	lyase activity
ES965_RS10935	COG1418	mRNA catabolic process
ES965_RS10940	COG0386	Belongs to the glutathione peroxidase family
ES965_RS10945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES965_RS10950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_RS10960	COG1278	Cold shock
ES965_RS10980	COG0328	RNA-DNA hybrid ribonuclease activity
ES965_RS10985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES965_RS10990	COG0328	RNA-DNA hybrid ribonuclease activity
ES965_RS11000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_RS11015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES965_RS11025	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES965_RS11030	COG3424	synthase
ES965_RS11035	COG2233	PERMEase
ES965_RS11040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_RS11045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES965_RS11055	COG0800	Aldolase
ES965_RS11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_RS11065	COG1609	Transcriptional regulator
ES965_RS11070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES965_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS11080	COG1199	ATP-dependent helicase activity
ES965_RS11095	COG0116	Belongs to the methyltransferase superfamily
ES965_RS11110	COG4474	Belongs to the UPF0398 family
ES965_RS11125	COG3359	exonuclease
ES965_RS11130	COG1111	helicase
ES965_RS11130	COG1205	dead DEAH box helicase
ES965_RS11135	COG2190	(PTS) system
ES965_RS11140	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_RS11175	COG3331	DNA recombination
ES965_RS11180	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES965_RS11180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_RS11190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES965_RS11195	COG3935	DnaD domain protein
ES965_RS11200	COG0017	Asparaginyl-tRNA synthetase
ES965_RS11205	COG0436	Aminotransferase
ES965_RS11210	COG5353	protein conserved in bacteria
ES965_RS11220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES965_RS11220	COG1199	ATP-dependent helicase activity
ES965_RS11225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES965_RS11230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES965_RS11235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES965_RS11240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES965_RS11240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES965_RS11245	COG0617	tRNA 3'-terminal CCA addition
ES965_RS11250	COG0438	transferase activity, transferring glycosyl groups
ES965_RS11255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_RS11260	COG1803	Methylglyoxal synthase
ES965_RS11265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES965_RS11270	COG1694	Mazg nucleotide pyrophosphohydrolase
ES965_RS11275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS11285	COG4347	Protein of unknown function (DUF1405)
ES965_RS11290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES965_RS11290	COG2010	Cytochrome c
ES965_RS11295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES965_RS11300	COG0723	plastoquinol--plastocyanin reductase activity
ES965_RS11310	COG5582	Belongs to the UPF0302 family
ES965_RS11315	COG0457	Tetratricopeptide repeat
ES965_RS11320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES965_RS11325	COG0287	Prephenate dehydrogenase
ES965_RS11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ES965_RS11335	COG0159	tryptophan synthase activity
ES965_RS11340	COG0133	tryptophan synthase activity
ES965_RS11345	COG0135	phosphoribosylanthranilate isomerase activity
ES965_RS11355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES965_RS11360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES965_RS11365	COG4401	Chorismate mutase type I
ES965_RS11370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES965_RS11375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES965_RS11380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES965_RS11385	COG0105	UTP biosynthetic process
ES965_RS11390	COG0142	geranyltranstransferase activity
ES965_RS11395	COG2226	methyltransferase
ES965_RS11400	COG0142	geranyltranstransferase activity
ES965_RS11410	COG0302	gtp cyclohydrolase
ES965_RS11415	COG0776	regulation of translation
ES965_RS11420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES965_RS11435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES965_RS11440	COG1160	GTP binding
ES965_RS11465	COG1304	FMN binding
ES965_RS11470	COG0539	negative regulation of cytoplasmic translation
ES965_RS11475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES965_RS11485	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES965_RS11490	COG2959	enzyme of heme biosynthesis
ES965_RS11495	COG3773	Cell wall hydrolase
ES965_RS11495	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS11500	COG2339	peptidase activity
ES965_RS11505	COG0492	ferredoxin-NADP+ reductase activity
ES965_RS11510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_RS11515	COG4862	establishment of competence for transformation
ES965_RS11520	COG1408	metallophosphoesterase
ES965_RS11530	COG1388	LysM domain
ES965_RS11535	COG1266	CAAX protease self-immunity
ES965_RS11540	COG0514	ATP-dependent DNA helicase (RecQ)
ES965_RS11545	COG4955	Helix-turn-helix domain
ES965_RS11550	COG1141	Ferredoxin
ES965_RS11555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES965_RS11560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES965_RS11565	COG0710	3-dehydroquinate dehydratase activity
ES965_RS11575	COG1595	DNA-templated transcription, initiation
ES965_RS11580	COG5002	protein histidine kinase activity
ES965_RS11585	COG0745	RESPONSE REGULATOR receiver
ES965_RS11590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES965_RS11595	COG1333	cytochrome c biogenesis protein
ES965_RS11600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS11605	COG1187	pseudouridine synthase activity
ES965_RS11610	COG0700	Nucleoside recognition
ES965_RS11615	COG2715	membrane protein required for spore maturation
ES965_RS11620	COG1686	Belongs to the peptidase S11 family
ES965_RS11630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES965_RS11635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES965_RS11640	COG1547	Domain of unknown function (DUF309)
ES965_RS11645	COG0456	acetyltransferase
ES965_RS11650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES965_RS11655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES965_RS11655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES965_RS11660	COG0307	riboflavin synthase, alpha
ES965_RS11665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES965_RS11665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES965_RS11675	COG0681	Belongs to the peptidase S26 family
ES965_RS11685	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES965_RS11715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES965_RS11725	COG4086	secreted protein
ES965_RS11730	COG0019	diaminopimelate decarboxylase activity
ES965_RS11735	COG0697	spore germination
ES965_RS11750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_RS11770	COG1191	sigma factor activity
ES965_RS11775	COG2172	sigma factor antagonist activity
ES965_RS11780	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS11785	COG1686	Belongs to the peptidase S11 family
ES965_RS11790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES965_RS11795	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES965_RS11800	COG4974	Belongs to the 'phage' integrase family
ES965_RS11810	COG0735	belongs to the Fur family
ES965_RS11815	COG1300	Membrane
ES965_RS11825	COG0281	malic enzyme
ES965_RS11830	COG1757	Na H antiporter
ES965_RS11835	COG1027	Aspartate ammonia-lyase
ES965_RS11840	COG0252	asparaginase activity
ES965_RS11845	COG1396	sequence-specific DNA binding
ES965_RS11850	COG1379	DNA repair
ES965_RS11855	COG0494	nUDIX hydrolase
ES965_RS11865	COG0667	Aldo Keto reductase
ES965_RS11875	COG1073	alpha beta
ES965_RS11885	COG4918	Iron-sulphur cluster biosynthesis
ES965_RS11890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES965_RS11890	COG0456	acetyltransferase
ES965_RS11895	COG2329	Antibiotic biosynthesis monooxygenase
ES965_RS11900	COG0456	acetyltransferase
ES965_RS11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_RS11920	COG2211	Major facilitator Superfamily
ES965_RS11925	COG0346	lactoylglutathione lyase activity
ES965_RS11930	COG1072	(Pantothenic acid kinase))
ES965_RS11935	COG3048	D-serine ammonia-lyase activity
ES965_RS11940	COG0300	oxidoreductase activity
ES965_RS11945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS11950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_RS11955	COG4187	Peptidase family M20/M25/M40
ES965_RS11960	COG1902	pentaerythritol trinitrate reductase activity
ES965_RS11965	COG0596	Alpha beta hydrolase
ES965_RS11975	COG1234	tRNA 3'-trailer cleavage
ES965_RS11980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES965_RS11985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES965_RS11990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_RS12000	COG0706	membrane insertase activity
ES965_RS12005	COG3361	conserved protein (COG2071)
ES965_RS12010	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES965_RS12015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES965_RS12020	COG0346	lactoylglutathione lyase activity
ES965_RS12025	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_RS12030	COG4129	membrane
ES965_RS12035	COG1126	abc transporter atp-binding protein
ES965_RS12040	COG0765	amino acid transport
ES965_RS12045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS12055	COG1597	lipid kinase activity
ES965_RS12060	COG2814	Major facilitator Superfamily
ES965_RS12065	COG4978	Transcriptional regulator
ES965_RS12065	COG0789	Transcriptional regulator
ES965_RS12070	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_RS12075	COG0022	dehydrogenase e1 component
ES965_RS12080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_RS12085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_RS12090	COG3426	butyrate kinase activity
ES965_RS12095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_RS12100	COG0280	phosphate acetyltransferase
ES965_RS12105	COG3290	protein histidine kinase activity
ES965_RS12105	COG3829	transcription factor binding
ES965_RS12115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES965_RS12120	COG2079	MmgE PrpD family protein
ES965_RS12125	COG0372	Belongs to the citrate synthase family
ES965_RS12130	COG1960	acyl-CoA dehydrogenase activity
ES965_RS12135	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES965_RS12140	COG0183	Belongs to the thiolase family
ES965_RS12145	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_RS12150	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS12165	COG1902	pentaerythritol trinitrate reductase activity
ES965_RS12170	COG0745	RESPONSE REGULATOR receiver
ES965_RS12175	COG0750	zinc metalloprotease
ES965_RS12180	COG0497	DNA recombination
ES965_RS12185	COG1438	arginine binding
ES965_RS12190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES965_RS12195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES965_RS12200	COG0142	geranyltranstransferase activity
ES965_RS12205	COG1722	exodeoxyribonuclease VII activity
ES965_RS12210	COG1570	exodeoxyribonuclease VII activity
ES965_RS12215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES965_RS12220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES965_RS12225	COG1302	Protein conserved in bacteria
ES965_RS12230	COG0439	Biotin carboxylase
ES965_RS12235	COG0511	ligase activity, forming carbon-carbon bonds
ES965_RS12275	COG3854	ATPases associated with a variety of cellular activities
ES965_RS12285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES965_RS12290	COG0006	proline dipeptidase activity
ES965_RS12295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES965_RS12305	COG3872	metal-dependent enzyme
ES965_RS12315	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES965_RS12320	COG1321	iron dependent repressor
ES965_RS12325	COG0095	Lipoate-protein ligase
ES965_RS12330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_RS12335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES965_RS12340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES965_RS12345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES965_RS12350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES965_RS12365	COG1396	sequence-specific DNA binding
ES965_RS12375	COG0681	Belongs to the peptidase S26 family
ES965_RS12400	COG4940	Competence protein ComGF
ES965_RS12410	COG4970	Tfp pilus assembly protein FimT
ES965_RS12415	COG4537	Required for transformation and DNA binding
ES965_RS12420	COG1459	type II secretion system
ES965_RS12425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES965_RS12430	COG0517	IMP dehydrogenase activity
ES965_RS12435	COG0598	Magnesium transport protein CorA
ES965_RS12440	COG1253	flavin adenine dinucleotide binding
ES965_RS12445	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS12455	COG1393	Belongs to the ArsC family
ES965_RS12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS12475	COG0011	TIGRFAM Protein of
ES965_RS12485	COG2866	Carboxypeptidase
ES965_RS12490	COG1368	sulfuric ester hydrolase activity
ES965_RS12495	COG1940	carbohydrate kinase activity
ES965_RS12500	COG4483	Protein conserved in bacteria
ES965_RS12505	COG0705	Rhomboid family
ES965_RS12505	COG0457	Tetratricopeptide repeat
ES965_RS12515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES965_RS12525	COG0438	transferase activity, transferring glycosyl groups
ES965_RS12540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES965_RS12545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_RS12550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_RS12555	COG0581	inorganic phosphate transmembrane transporter activity
ES965_RS12560	COG0573	inorganic phosphate transmembrane transporter activity
ES965_RS12565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES965_RS12570	COG0768	penicillin binding
ES965_RS12575	COG0477	Major facilitator Superfamily
ES965_RS12580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES965_RS12585	COG2839	Protein conserved in bacteria
ES965_RS12590	COG5521	maltodextrose utilization protein MalA
ES965_RS12595	COG1388	LysM domain
ES965_RS12600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES965_RS12605	COG4709	membrane
ES965_RS12610	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES965_RS12615	COG0735	belongs to the Fur family
ES965_RS12620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS12630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES965_RS12635	COG0513	Belongs to the DEAD box helicase family
ES965_RS12645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES965_RS12650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES965_RS12655	COG2384	SAM-dependent methyltransferase
ES965_RS12660	COG2010	Cytochrome c
ES965_RS12665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES965_RS12670	COG0358	DNA primase activity
ES965_RS12675	COG1671	Belongs to the UPF0178 family
ES965_RS12680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES965_RS12685	COG0517	IMP dehydrogenase activity
ES965_RS12690	COG0751	glycine-tRNA ligase activity
ES965_RS12695	COG0752	glycyl-tRNA synthetase alpha subunit
ES965_RS12700	COG1381	Involved in DNA repair and RecF pathway recombination
ES965_RS12710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES965_RS12715	COG0295	cytidine deaminase activity
ES965_RS12720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES965_RS12725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES965_RS12730	COG1480	7TM receptor with intracellular HD hydrolase
ES965_RS12735	COG1702	phosphate starvation-inducible protein PhoH
ES965_RS12740	COG0561	phosphatase activity
ES965_RS12755	COG4864	UPF0365 protein
ES965_RS12760	COG1030	water channel activity
ES965_RS12765	COG1610	YqeY-like protein
ES965_RS12775	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES965_RS12780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES965_RS12785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES965_RS12790	COG2264	protein methyltransferase activity
ES965_RS12795	COG0484	heat shock protein binding
ES965_RS12800	COG0443	Heat shock 70 kDa protein
ES965_RS12805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES965_RS12810	COG1420	regulation of RNA biosynthetic process
ES965_RS12815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES965_RS12820	COG0481	GTPase activity
ES965_RS12830	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS12835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES965_RS12840	COG0268	Binds directly to 16S ribosomal RNA
ES965_RS12845	COG1466	dna polymerase III delta subunit
ES965_RS12860	COG0658	competence protein
ES965_RS12860	COG2333	competence protein COMEC
ES965_RS12865	COG2131	deaminase
ES965_RS12870	COG1596	polysaccharide export
ES965_RS12870	COG1555	photosystem II stabilization
ES965_RS12875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_RS12880	COG2226	methyltransferase
ES965_RS12885	COG0799	negative regulation of ribosome biogenesis
ES965_RS12890	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES965_RS12895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES965_RS12900	COG1534	Rna-binding protein
ES965_RS12905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES965_RS12910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES965_RS12915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES965_RS12925	COG2755	lipolytic protein G-D-S-L family
ES965_RS12930	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_RS12930	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS12935	COG0398	Pfam SNARE associated Golgi protein
ES965_RS12940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES965_RS12950	COG3209	COG3209 Rhs family protein
ES965_RS12965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES965_RS12975	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_RS12985	COG0697	spore germination
ES965_RS12990	COG1802	Transcriptional regulator
ES965_RS12995	COG0730	response to heat
ES965_RS13000	COG0425	Belongs to the sulfur carrier protein TusA family
ES965_RS13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS13005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_RS13015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_RS13015	COG0425	Belongs to the sulfur carrier protein TusA family
ES965_RS13025	COG2210	Belongs to the sulfur carrier protein TusA family
ES965_RS13030	COG1937	Protein conserved in bacteria
ES965_RS13045	COG0662	Cupin 2, conserved barrel domain protein
ES965_RS13060	COG4978	Transcriptional regulator
ES965_RS13060	COG0789	Transcriptional regulator
ES965_RS13065	COG2814	Major facilitator Superfamily
ES965_RS13070	COG0456	acetyltransferase
ES965_RS13075	COG1253	flavin adenine dinucleotide binding
ES965_RS13085	COG0697	spore germination
ES965_RS13090	COG0583	DNA-binding transcription factor activity
ES965_RS13095	COG2072	flavoprotein involved in K transport
ES965_RS13100	COG1230	cation diffusion facilitator family transporter
ES965_RS13105	COG1942	4-Oxalocrotonate Tautomerase
ES965_RS13110	COG0583	DNA-binding transcription factor activity
ES965_RS13120	COG1114	Component of the transport system for branched-chain amino acids
ES965_RS13125	COG1687	branched-chain amino acid
ES965_RS13130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES965_RS13135	COG1522	sequence-specific DNA binding
ES965_RS13140	COG2732	(Barnase) inhibitor
ES965_RS13145	COG2124	cytochrome p450
ES965_RS13160	COG1609	Transcriptional regulator
ES965_RS13170	COG1175	transmembrane transport
ES965_RS13175	COG0395	ABC-type sugar transport system, permease component
ES965_RS13195	COG0110	maltose O-acetyltransferase activity
ES965_RS13205	COG1335	isochorismatase
ES965_RS13220	COG2318	DinB family
ES965_RS13230	COG2070	2-Nitropropane dioxygenase
ES965_RS13245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES965_RS13275	COG4978	Transcriptional regulator
ES965_RS13275	COG0789	Transcriptional regulator
ES965_RS13280	COG2315	Protein conserved in bacteria
ES965_RS13290	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES965_RS13295	COG1595	DNA-templated transcription, initiation
ES965_RS13300	COG0667	Aldo Keto reductase
ES965_RS13305	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS13310	COG5566	PFAM Mor transcription activator
ES965_RS13315	COG0596	Alpha beta hydrolase
ES965_RS13320	COG4991	sh3 domain protein
ES965_RS13325	COG4991	sh3 domain protein
ES965_RS13330	COG0346	lactoylglutathione lyase activity
ES965_RS13340	COG5577	PFAM Coat F domain
ES965_RS13345	COG1063	alcohol dehydrogenase
ES965_RS13355	COG5577	PFAM Coat F domain
ES965_RS13360	COG0789	Transcriptional regulator
ES965_RS13370	COG1064	alcohol dehydrogenase
ES965_RS13375	COG0693	protein deglycase activity
ES965_RS13380	COG1621	beta-fructofuranosidase activity
ES965_RS13385	COG3716	PTS system mannose fructose sorbose family IID component
ES965_RS13390	COG3715	PTS system
ES965_RS13395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS13400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS13405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES965_RS13405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES965_RS13415	COG1113	amino acid transport
ES965_RS13420	COG1280	lysine exporter protein (LysE YggA)
ES965_RS13425	COG1378	Sugar-specific transcriptional regulator TrmB
ES965_RS13430	COG1595	DNA-templated transcription, initiation
ES965_RS13440	COG2755	lipolytic protein G-D-S-L family
ES965_RS13440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES965_RS13450	COG2124	cytochrome p450
ES965_RS13450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_RS13455	COG1309	transcriptional regulator
ES965_RS13460	COG2226	methyltransferase
ES965_RS13475	COG2116	formate transmembrane transporter activity
ES965_RS13480	COG5609	conserved protein (DUF2294)
ES965_RS13485	COG3383	formate dehydrogenase (NAD+) activity
ES965_RS13490	COG2427	Protein of unknown function (DUF1641)
ES965_RS13500	COG0626	cystathionine gamma-synthase activity
ES965_RS13505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_RS13510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES965_RS13515	COG2226	methyltransferase
ES965_RS13530	COG0768	penicillin binding
ES965_RS13535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES965_RS13540	COG0572	uridine kinase
ES965_RS13545	COG0826	peptidase U32
ES965_RS13550	COG0826	peptidase U32
ES965_RS13555	COG4122	O-methyltransferase activity
ES965_RS13560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES965_RS13565	COG3906	Belongs to the UPF0473 family
ES965_RS13570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES965_RS13575	COG4472	Bacterial protein of unknown function (DUF965)
ES965_RS13580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES965_RS13585	COG0628	permease
ES965_RS13590	COG1126	abc transporter atp-binding protein
ES965_RS13595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS13600	COG0765	amino acid transport
ES965_RS13605	COG0765	amino acid transport
ES965_RS13620	COG3881	PFAM PRC-barrel domain
ES965_RS13625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES965_RS13630	COG0457	Tetratricopeptide repeat
ES965_RS13635	COG0482	sulfurtransferase activity
ES965_RS13640	COG1104	cysteine desulfurase activity
ES965_RS13645	COG1959	2 iron, 2 sulfur cluster binding
ES965_RS13650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES965_RS13655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES965_RS13665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES965_RS13670	COG0124	histidyl-tRNA synthetase
ES965_RS13680	COG4991	sh3 domain protein
ES965_RS13680	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS13680	COG3103	Sh3 type 3 domain protein
ES965_RS13685	COG1490	D-aminoacyl-tRNA deacylase activity
ES965_RS13690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES965_RS13695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_RS13700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES965_RS13700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES965_RS13705	COG5416	Lipopolysaccharide assembly protein A domain
ES965_RS13710	COG0490	domain, Protein
ES965_RS13715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES965_RS13715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES965_RS13725	COG2244	polysaccharide biosynthetic process
ES965_RS13730	COG2323	membrane
ES965_RS13745	COG1862	Preprotein translocase
ES965_RS13750	COG0343	queuine tRNA-ribosyltransferase activity
ES965_RS13755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES965_RS13765	COG2255	four-way junction helicase activity
ES965_RS13770	COG0632	four-way junction helicase activity
ES965_RS13780	COG2814	Major facilitator Superfamily
ES965_RS13785	COG0673	inositol 2-dehydrogenase activity
ES965_RS13790	COG2112	serine threonine protein kinase
ES965_RS13810	COG1115	amino acid carrier protein
ES965_RS13815	COG0217	transcriptional regulatory protein
ES965_RS13825	COG1388	LysM domain
ES965_RS13830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES965_RS13835	COG0157	Belongs to the NadC ModD family
ES965_RS13840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES965_RS13845	COG1104	cysteine desulfurase activity
ES965_RS13850	COG1827	regulation of RNA biosynthetic process
ES965_RS13855	COG0077	Prephenate dehydratase
ES965_RS13860	COG4492	Belongs to the UPF0735 family
ES965_RS13865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES965_RS13870	COG3290	protein histidine kinase activity
ES965_RS13880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES965_RS13885	COG2868	ribosomal protein
ES965_RS13890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES965_RS13895	COG1994	Peptidase M50
ES965_RS13900	COG0739	heme binding
ES965_RS13905	COG2894	cell division
ES965_RS13910	COG0850	regulation of cytokinetic process
ES965_RS13915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES965_RS13925	COG1077	Cell shape determining protein MreB Mrl
ES965_RS13930	COG2003	Belongs to the UPF0758 family
ES965_RS13935	COG0424	maF-like protein
ES965_RS13945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES965_RS13950	COG0285	dihydrofolate synthase activity
ES965_RS13955	COG0525	valine-tRNA ligase activity
ES965_RS13965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_RS13970	COG1388	LysM domain
ES965_RS13975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES965_RS13980	COG0113	porphobilinogen synthase activity
ES965_RS13985	COG1587	Uroporphyrinogen-III synthase
ES965_RS13990	COG0181	hydroxymethylbilane synthase activity
ES965_RS13995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES965_RS14000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES965_RS14010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES965_RS14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES965_RS14020	COG1067	ATP-dependent peptidase activity
ES965_RS14020	COG0470	DNA polymerase III
ES965_RS14025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES965_RS14030	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES965_RS14035	COG0457	Tetratricopeptide repeat
ES965_RS14035	COG1477	protein flavinylation
ES965_RS14040	COG0066	3-isopropylmalate dehydratase activity
ES965_RS14045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES965_RS14050	COG0473	3-isopropylmalate dehydrogenase activity
ES965_RS14055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES965_RS14060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES965_RS14065	COG0440	acetolactate synthase activity
ES965_RS14070	COG0028	Belongs to the TPP enzyme family
ES965_RS14080	COG0454	-acetyltransferase
ES965_RS14090	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES965_RS14115	COG1674	ftsk spoiiie
ES965_RS14145	COG1388	LysM domain
ES965_RS14145	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_RS14145	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS14180	COG5280	Phage tail tape measure protein TP901
ES965_RS14180	COG3953	SLT domain
ES965_RS14225	COG0740	serine-type endopeptidase activity
ES965_RS14275	COG0322	excinuclease ABC activity
ES965_RS14280	COG1216	Glycosyl transferase, family 2
ES965_RS14290	COG4195	phage-related replication protein
ES965_RS14295	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_RS14295	COG3420	alginic acid biosynthetic process
ES965_RS14360	COG1388	LysM domain
ES965_RS14360	COG3584	3D domain protein
ES965_RS14365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ES965_RS14370	COG0756	dUTP diphosphatase activity
ES965_RS14375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_RS14385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_RS14390	COG1780	Probably involved in ribonucleotide reductase function
ES965_RS14430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_RS14430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_RS14490	COG1484	DNA-dependent DNA replication
ES965_RS14540	COG0622	Phosphoesterase
ES965_RS14545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES965_RS14550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES965_RS14555	COG5401	PFAM Sporulation and spore germination
ES965_RS14560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES965_RS14565	COG1846	Transcriptional regulator
ES965_RS14570	COG2197	response regulator
ES965_RS14575	COG0824	Thioesterase
ES965_RS14580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES965_RS14585	COG1053	succinate dehydrogenase
ES965_RS14590	COG2009	succinate dehydrogenase
ES965_RS14595	COG1719	4-vinyl reductase, 4VR
ES965_RS14600	COG0527	aspartate kinase activity
ES965_RS14610	COG0322	excinuclease ABC activity
ES965_RS14615	COG3118	belongs to the thioredoxin family
ES965_RS14625	COG3534	alpha-L-arabinofuranosidase
ES965_RS14630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES965_RS14635	COG2086	electron transfer activity
ES965_RS14640	COG1024	Enoyl-CoA hydratase
ES965_RS14645	COG1309	transcriptional regulator
ES965_RS14650	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS14655	COG3766	membrane
ES965_RS14660	COG1193	negative regulation of DNA recombination
ES965_RS14665	COG1796	DNA polymerase
ES965_RS14665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES965_RS14670	COG1286	toxin biosynthetic process
ES965_RS14675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES965_RS14680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES965_RS14685	COG0072	phenylalanine-tRNA ligase activity
ES965_RS14685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_RS14690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES965_RS14700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES965_RS14710	COG3835	regulator
ES965_RS14715	COG0277	FAD linked oxidase domain protein
ES965_RS14720	COG0247	lactate metabolic process
ES965_RS14725	COG0346	lactoylglutathione lyase activity
ES965_RS14735	COG1966	Carbon starvation protein
ES965_RS14740	COG3534	alpha-L-arabinofuranosidase
ES965_RS14745	COG0395	ABC-type sugar transport system, permease component
ES965_RS14750	COG1175	transmembrane transport
ES965_RS14755	COG1653	transport
ES965_RS14760	COG0371	Dehydrogenase
ES965_RS14765	COG0647	UMP catabolic process
ES965_RS14770	COG0235	Class ii aldolase
ES965_RS14775	COG1069	ribulokinase activity
ES965_RS14780	COG2160	L-arabinose isomerase activity
ES965_RS14785	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_RS14790	COG1363	Peptidase, m42
ES965_RS14800	COG3326	Membrane
ES965_RS14805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES965_RS14810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES965_RS14815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES965_RS14825	COG1346	cytolysis
ES965_RS14830	COG1380	Effector of murein hydrolase LrgA
ES965_RS14835	COG3279	Response regulator of the LytR AlgR family
ES965_RS14840	COG3275	phosphorelay sensor kinase activity
ES965_RS14845	COG1011	Hydrolase
ES965_RS14850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES965_RS14860	COG0398	Pfam SNARE associated Golgi protein
ES965_RS14865	COG1484	DNA-dependent DNA replication
ES965_RS14870	COG3611	Membrane attachment protein
ES965_RS14875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES965_RS14880	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES965_RS14885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES965_RS14890	COG1733	regulation of RNA biosynthetic process
ES965_RS14895	COG2814	Major facilitator Superfamily
ES965_RS14900	COG0656	L-ascorbic acid biosynthetic process
ES965_RS14905	COG0237	dephospho-CoA kinase activity
ES965_RS14910	COG1971	Probably functions as a manganese efflux pump
ES965_RS14915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES965_RS14920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_RS14920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_RS14925	COG5002	protein histidine kinase activity
ES965_RS14930	COG0745	RESPONSE REGULATOR receiver
ES965_RS14935	COG0039	L-malate dehydrogenase activity
ES965_RS14940	COG0538	isocitrate dehydrogenase activity
ES965_RS14945	COG0372	Belongs to the citrate synthase family
ES965_RS14950	COG2707	UPF0756 membrane protein
ES965_RS14955	COG0628	permease
ES965_RS14960	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES965_RS14965	COG0469	pyruvate kinase activity
ES965_RS14970	COG0205	6-phosphofructokinase activity
ES965_RS14975	COG0825	malonyl-CoA metabolic process
ES965_RS14980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES965_RS14985	COG0281	malic enzyme
ES965_RS14990	COG0587	DNA-directed DNA polymerase activity
ES965_RS15010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES965_RS15020	COG4109	DRTGG domain
ES965_RS15025	COG0730	response to heat
ES965_RS15030	COG1473	amidohydrolase
ES965_RS15035	COG0196	riboflavin kinase activity
ES965_RS15040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS15045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ES965_RS15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS15055	COG1126	abc transporter atp-binding protein
ES965_RS15060	COG0765	amino acid transport
ES965_RS15065	COG0765	amino acid transport
ES965_RS15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS15075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS15080	COG0454	-acetyltransferase
ES965_RS15085	COG0583	DNA-binding transcription factor activity
ES965_RS15090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES965_RS15095	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS15105	COG0165	Argininosuccinate lyase
ES965_RS15110	COG0137	argininosuccinate synthase activity
ES965_RS15115	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES965_RS15120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES965_RS15130	COG0827	DNA restriction-modification system
ES965_RS15135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES965_RS15140	COG3874	Sporulation protein YtfJ
ES965_RS15150	COG1714	RDD family
ES965_RS15155	COG0616	signal peptide processing
ES965_RS15160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES965_RS15165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES965_RS15170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES965_RS15180	COG0301	tRNA thio-modification
ES965_RS15185	COG1104	cysteine desulfurase activity
ES965_RS15190	COG1114	Component of the transport system for branched-chain amino acids
ES965_RS15195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES965_RS15200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES965_RS15205	COG1309	transcriptional regulator
ES965_RS15210	COG1956	GAF domain-containing protein
ES965_RS15215	COG2203	Gaf domain
ES965_RS15215	COG2199	diguanylate cyclase activity
ES965_RS15225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES965_RS15230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES965_RS15235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES965_RS15240	COG0454	-acetyltransferase
ES965_RS15245	COG0517	IMP dehydrogenase activity
ES965_RS15250	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES965_RS15255	COG1360	Flagellar Motor Protein
ES965_RS15260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES965_RS15265	COG1609	Transcriptional regulator
ES965_RS15270	COG1605	Chorismate mutase
ES965_RS15270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES965_RS15275	COG3118	belongs to the thioredoxin family
ES965_RS15280	COG4980	gas vesicle protein
ES965_RS15285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES965_RS15290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES965_RS15295	COG1674	ftsk spoiiie
ES965_RS15300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_RS15305	COG4848	Belongs to the UPF0354 family
ES965_RS15310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS15325	COG1363	Peptidase, m42
ES965_RS15330	COG5584	Small secreted protein
ES965_RS15335	COG0281	malic enzyme
ES965_RS15340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS15345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES965_RS15355	COG0510	thiamine kinase activity
ES965_RS15360	COG1523	belongs to the glycosyl hydrolase 13 family
ES965_RS15365	COG1597	lipid kinase activity
ES965_RS15375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES965_RS15380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_RS15385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_RS15390	COG2252	PERMEase
ES965_RS15395	COG4473	ABC transporter
ES965_RS15400	COG1131	(ABC) transporter
ES965_RS15405	COG1349	DNA-binding transcription factor activity
ES965_RS15410	COG1187	pseudouridine synthase activity
ES965_RS15415	COG2244	polysaccharide biosynthetic process
ES965_RS15420	COG2081	HI0933 family
ES965_RS15425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES965_RS15435	COG5578	integral membrane protein
ES965_RS15440	COG0673	inositol 2-dehydrogenase activity
ES965_RS15445	COG1653	transport
ES965_RS15450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES965_RS15455	COG4209	transmembrane transport
ES965_RS15460	COG2207	Transcriptional regulator
ES965_RS15465	COG1653	transport
ES965_RS15470	COG0395	ABC-type sugar transport system, permease component
ES965_RS15475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_RS15480	COG2124	cytochrome p450
ES965_RS15485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES965_RS15495	COG0156	8-amino-7-oxononanoate synthase activity
ES965_RS15500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_RS15505	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ES965_RS15510	COG1073	alpha beta
ES965_RS15515	COG1609	Transcriptional regulator
ES965_RS15520	COG1653	transport
ES965_RS15525	COG1175	transmembrane transport
ES965_RS15530	COG0395	ABC-type sugar transport system, permease component
ES965_RS15535	COG1486	melibiose metabolic process
ES965_RS15540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_RS15545	COG0495	leucyl-tRNA aminoacylation
ES965_RS15555	COG2202	Pas domain
ES965_RS15555	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_RS15560	COG2814	Major facilitator Superfamily
ES965_RS15565	COG2433	Pfam Transposase IS66
ES965_RS15570	COG0577	efflux transmembrane transporter activity
ES965_RS15575	COG1136	(ABC) transporter
ES965_RS15580	COG2205	protein histidine kinase activity
ES965_RS15585	COG0745	RESPONSE REGULATOR receiver
ES965_RS15590	COG0577	efflux transmembrane transporter activity
ES965_RS15595	COG1136	(ABC) transporter
ES965_RS15610	COG1131	(ABC) transporter
ES965_RS15615	COG1725	Transcriptional regulator
ES965_RS15630	COG1242	4 iron, 4 sulfur cluster binding
ES965_RS15635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES965_RS15645	COG2267	carboxylic ester hydrolase activity
ES965_RS15650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES965_RS15655	COG1113	amino acid transport
ES965_RS15660	COG0367	asparagine synthase
ES965_RS15665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES965_RS15670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES965_RS15680	COG1506	peptidase
ES965_RS15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES965_RS15690	COG1116	anion transmembrane transporter activity
ES965_RS15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES965_RS15700	COG0494	nUDIX hydrolase
ES965_RS15705	COG4824	toxin secretion phage lysis holin
ES965_RS15710	COG0783	Belongs to the Dps family
ES965_RS15725	COG1854	S-ribosylhomocysteine lyase activity
ES965_RS15730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES965_RS15735	COG0288	reversible hydration of carbon dioxide
ES965_RS15740	COG0254	rRNA binding
ES965_RS15745	COG1271	oxidase subunit
ES965_RS15750	COG1294	oxidase, subunit
ES965_RS15760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_RS15765	COG1321	iron dependent repressor
ES965_RS15765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_RS15770	COG1121	(ABC) transporter
ES965_RS15775	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES965_RS15780	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_RS15785	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_RS15790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES965_RS15795	COG0596	Alpha beta hydrolase
ES965_RS15800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES965_RS15805	COG1169	isochorismate synthase
ES965_RS15815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_RS15820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_RS15825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_RS15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_RS15835	COG0438	transferase activity, transferring glycosyl groups
ES965_RS15845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_RS15850	COG0438	transferase activity, transferring glycosyl groups
ES965_RS15855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_RS15860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES965_RS15865	COG0058	SHG alpha-glucan phosphorylase activity
ES965_RS15870	COG0297	glycogen (starch) synthase activity
ES965_RS15875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES965_RS15880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES965_RS15885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES965_RS16010	COG3859	Proton-coupled thiamine transporter YuaJ
ES965_RS16015	COG1247	-acetyltransferase
ES965_RS16020	COG2268	Band 7 protein
ES965_RS16025	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES965_RS16030	COG2318	DinB family
ES965_RS16040	COG1454	alcohol dehydrogenase
ES965_RS16045	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS16050	COG1510	regulation of RNA biosynthetic process
ES965_RS16060	COG0569	domain protein
ES965_RS16065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES965_RS16070	COG4682	membrane
ES965_RS16075	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES965_RS16080	COG0477	Major facilitator Superfamily
ES965_RS16085	COG5553	Cysteine dioxygenase type I
ES965_RS16095	COG1968	undecaprenyl-diphosphatase activity
ES965_RS16100	COG0628	permease
ES965_RS16105	COG0673	inositol 2-dehydrogenase activity
ES965_RS16110	COG4806	L-rhamnose isomerase
ES965_RS16115	COG3254	rhamnose metabolic process
ES965_RS16120	COG1070	Carbohydrate kinase
ES965_RS16125	COG1349	DNA-binding transcription factor activity
ES965_RS16130	COG3347	Dehydrogenase
ES965_RS16130	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS16140	COG0840	transmembrane signaling receptor activity
ES965_RS16145	COG0840	transmembrane signaling receptor activity
ES965_RS16150	COG0840	transmembrane signaling receptor activity
ES965_RS16155	COG0840	transmembrane signaling receptor activity
ES965_RS16170	COG0432	Pfam Uncharacterised protein family UPF0047
ES965_RS16180	COG0366	Alpha amylase catalytic
ES965_RS16185	COG1253	flavin adenine dinucleotide binding
ES965_RS16190	COG2738	Putative neutral zinc metallopeptidase
ES965_RS16205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES965_RS16220	COG0166	Belongs to the GPI family
ES965_RS16225	COG1979	alcohol dehydrogenase
ES965_RS16230	COG1979	alcohol dehydrogenase
ES965_RS16235	COG2155	Conserved Protein
ES965_RS16240	COG1098	S1 RNA binding domain
ES965_RS16245	COG0436	Aminotransferase
ES965_RS16250	COG1522	sequence-specific DNA binding
ES965_RS16255	COG2267	carboxylic ester hydrolase activity
ES965_RS16265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES965_RS16270	COG2205	protein histidine kinase activity
ES965_RS16280	COG5018	Exonuclease
ES965_RS16290	COG2814	Major facilitator Superfamily
ES965_RS16295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_RS16300	COG3011	Protein conserved in bacteria
ES965_RS16310	COG3290	protein histidine kinase activity
ES965_RS16315	COG4565	transcriptional regulatory protein
ES965_RS16320	COG1744	ABC transporter substrate-binding protein PnrA-like
ES965_RS16325	COG3845	ABC transporter
ES965_RS16330	COG4603	Belongs to the binding-protein-dependent transport system permease family
ES965_RS16335	COG1079	Belongs to the binding-protein-dependent transport system permease family
ES965_RS16340	COG3493	citrate carrier protein
ES965_RS16350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES965_RS16350	COG2111	Na H antiporter
ES965_RS16355	COG2111	Na H antiporter
ES965_RS16360	COG1006	Multisubunit Na H antiporter MnhC subunit
ES965_RS16365	COG0651	ATP synthesis coupled electron transport
ES965_RS16370	COG1863	multisubunit Na H antiporter MnhE subunit
ES965_RS16375	COG2212	antiporter activity
ES965_RS16380	COG1320	monovalent cation:proton antiporter activity
ES965_RS16385	COG2050	protein possibly involved in aromatic compounds catabolism
ES965_RS16390	COG2197	response regulator
ES965_RS16395	COG4585	Histidine kinase
ES965_RS16405	COG0142	geranyltranstransferase activity
ES965_RS16420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES965_RS16425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES965_RS16430	COG1335	isochorismatase
ES965_RS16435	COG5506	Protein of unknown function (DUF1694)
ES965_RS16450	COG0628	permease
ES965_RS16465	COG1418	mRNA catabolic process
ES965_RS16470	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS16480	COG1511	domain protein
ES965_RS16485	COG1674	ftsk spoiiie
ES965_RS16485	COG0433	COG0433 Predicted ATPase
ES965_RS16490	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES965_RS16495	COG5417	Belongs to the EsaB family
ES965_RS16500	COG4842	Belongs to the WXG100 family
ES965_RS16510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES965_RS16510	COG2508	Transcriptional regulator
ES965_RS16515	COG0686	Belongs to the AlaDH PNT family
ES965_RS16520	COG5634	Uncharacterized conserved protein (DUF2278)
ES965_RS16525	COG3251	PFAM MbtH domain protein
ES965_RS16530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS16535	COG1535	isochorismatase
ES965_RS16535	COG3433	isochorismatase activity
ES965_RS16540	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES965_RS16545	COG1169	isochorismate synthase
ES965_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS16555	COG2819	hydrolase of the alpha beta superfamily
ES965_RS16560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES965_RS16565	COG1268	BioY protein
ES965_RS16570	COG2056	Na+-H+ antiporter family
ES965_RS16575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES965_RS16580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES965_RS16585	COG3584	3D domain protein
ES965_RS16600	COG1252	NADH dehydrogenase
ES965_RS16605	COG0492	ferredoxin-NADP+ reductase activity
ES965_RS16615	COG0516	GMP reductase activity
ES965_RS16620	COG2808	Putative FMN-binding domain
ES965_RS16625	COG0456	acetyltransferase
ES965_RS16630	COG0316	Belongs to the HesB IscA family
ES965_RS16635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES965_RS16640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_RS16645	COG4844	belongs to the
ES965_RS16650	COG1252	NADH dehydrogenase
ES965_RS16655	COG4837	Protein of unknown function (DUF1462)
ES965_RS16660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES965_RS16665	COG0823	Involved in the tonB-independent uptake of proteins
ES965_RS16665	COG1506	peptidase
ES965_RS16665	COG4946	Tricorn protease homolog
ES965_RS16670	COG0083	homoserine kinase activity
ES965_RS16675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES965_RS16680	COG0460	homoserine dehydrogenase
ES965_RS16685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_RS16690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES965_RS16695	COG0647	UMP catabolic process
ES965_RS16700	COG2445	Protein of unknown function DUF86
ES965_RS16705	COG4470	Protein conserved in bacteria
ES965_RS16715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES965_RS16720	COG0739	heme binding
ES965_RS16730	COG3377	Domain of unknown function (DUF1805)
ES965_RS16735	COG0737	Belongs to the 5'-nucleotidase family
ES965_RS16740	COG0730	response to heat
ES965_RS16745	COG1801	Protein of unknown function DUF72
ES965_RS16755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES965_RS16760	COG2508	Transcriptional regulator
ES965_RS16765	COG2233	PERMEase
ES965_RS16770	COG2233	PERMEase
ES965_RS16775	COG3648	Uricase
ES965_RS16775	COG3195	allantoin biosynthetic process
ES965_RS16780	COG2351	hydroxyisourate hydrolase activity
ES965_RS16790	COG2080	2 iron, 2 sulfur cluster binding
ES965_RS16795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES965_RS16800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES965_RS16805	COG2068	MobA-Related Protein
ES965_RS16810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES965_RS16815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES965_RS16820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_RS16830	COG2356	endonuclease I
ES965_RS16835	COG3842	ATPase activity
ES965_RS16840	COG2188	Transcriptional regulator
ES965_RS16845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_RS16850	COG0395	ABC-type sugar transport system, permease component
ES965_RS16855	COG1175	transmembrane transport
ES965_RS16860	COG1653	transport
ES965_RS16865	COG2222	sugar isomerase
ES965_RS16870	COG0322	excinuclease ABC activity
ES965_RS16875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_RS16890	COG0346	lactoylglutathione lyase activity
ES965_RS16895	COG0640	Transcriptional regulator
ES965_RS16900	COG0719	Fe-S assembly protein
ES965_RS16905	COG0822	iron-sulfur transferase activity
ES965_RS16910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES965_RS16915	COG0719	Fe-S assembly protein
ES965_RS16920	COG0396	ATPase activity
ES965_RS16935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES965_RS16940	COG1464	Belongs to the NlpA lipoprotein family
ES965_RS16945	COG2011	ABC-type metal ion transport system permease component
ES965_RS16950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES965_RS16960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_RS16965	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES965_RS16975	COG0509	glycine decarboxylation via glycine cleavage system
ES965_RS16980	COG1393	Belongs to the ArsC family
ES965_RS16985	COG1960	acyl-CoA dehydrogenase activity
ES965_RS16990	COG0183	Belongs to the thiolase family
ES965_RS16995	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES965_RS16995	COG1024	Enoyl-CoA hydratase
ES965_RS17005	COG0506	proline dehydrogenase activity
ES965_RS17015	COG5577	PFAM Coat F domain
ES965_RS17025	COG0477	Major facilitator Superfamily
ES965_RS17030	COG1942	4-Oxalocrotonate Tautomerase
ES965_RS17035	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS17040	COG0583	DNA-binding transcription factor activity
ES965_RS17050	COG1120	ATPase activity
ES965_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS17070	COG0783	Belongs to the Dps family
ES965_RS17075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_RS17080	COG0745	RESPONSE REGULATOR receiver
ES965_RS17085	COG2770	Histidine kinase
ES965_RS17085	COG2205	protein histidine kinase activity
ES965_RS17095	COG1309	transcriptional regulator
ES965_RS17100	COG0114	fumarate hydratase activity
ES965_RS17110	COG0697	spore germination
ES965_RS17115	COG0814	amino acid
ES965_RS17125	COG2197	response regulator
ES965_RS17130	COG4585	Histidine kinase
ES965_RS17135	COG4758	membrane
ES965_RS17140	COG3595	metallopeptidase activity
ES965_RS17145	COG1842	Phage shock protein A
ES965_RS17150	COG4758	membrane
ES965_RS17155	COG2814	Major facilitator Superfamily
ES965_RS17160	COG2096	Adenosyltransferase
ES965_RS17165	COG1120	ATPase activity
ES965_RS17170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS17175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS17185	COG3386	PFAM SMP-30 Gluconolaconase
ES965_RS17190	COG2205	protein histidine kinase activity
ES965_RS17195	COG0745	RESPONSE REGULATOR receiver
ES965_RS17205	COG1191	sigma factor activity
ES965_RS17215	COG2140	Oxalate decarboxylase
ES965_RS17225	COG0577	efflux transmembrane transporter activity
ES965_RS17230	COG1136	(ABC) transporter
ES965_RS17235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES965_RS17240	COG1120	ATPase activity
ES965_RS17245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS17250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_RS17255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS17260	COG0531	amino acid
ES965_RS17275	COG1988	membrane-bound metal-dependent
ES965_RS17280	COG1368	sulfuric ester hydrolase activity
ES965_RS17285	COG1910	domain protein
ES965_RS17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES965_RS17295	COG4149	molybdate abc transporter
ES965_RS17300	COG0656	L-ascorbic acid biosynthetic process
ES965_RS17310	COG0025	NhaP-type Na H and K H
ES965_RS17315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_RS17320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_RS17325	COG3973	AAA domain
ES965_RS17335	COG2860	membrane
ES965_RS17340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES965_RS17345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES965_RS17350	COG2217	Heavy metal translocating P-type atpase
ES965_RS17355	COG2217	Heavy metal translocating P-type atpase
ES965_RS17360	COG2608	mercury ion transmembrane transporter activity
ES965_RS17365	COG1937	Protein conserved in bacteria
ES965_RS17370	COG0673	inositol 2-dehydrogenase activity
ES965_RS17375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES965_RS17380	COG1289	transmembrane transporter activity
ES965_RS17390	COG2076	Multidrug Resistance protein
ES965_RS17395	COG1309	transcriptional regulator
ES965_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS17410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES965_RS17415	COG0557	exoribonuclease II activity
ES965_RS17420	COG1647	Serine aminopeptidase, S33
ES965_RS17425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES965_RS17430	COG0596	Alpha beta hydrolase
ES965_RS17435	COG1476	TRANSCRIPTIONal
ES965_RS17440	COG1396	sequence-specific DNA binding
ES965_RS17445	COG1396	sequence-specific DNA binding
ES965_RS17450	COG1733	regulation of RNA biosynthetic process
ES965_RS17475	COG1174	glycine betaine transport
ES965_RS17480	COG1732	Glycine betaine
ES965_RS17485	COG1174	glycine betaine transport
ES965_RS17490	COG0517	IMP dehydrogenase activity
ES965_RS17490	COG1125	glycine betaine transport
ES965_RS17495	COG1510	regulation of RNA biosynthetic process
ES965_RS17500	COG1174	glycine betaine transport
ES965_RS17505	COG1732	Glycine betaine
ES965_RS17510	COG1174	glycine betaine transport
ES965_RS17515	COG1125	glycine betaine transport
ES965_RS17515	COG0517	IMP dehydrogenase activity
ES965_RS17520	COG1510	regulation of RNA biosynthetic process
ES965_RS17525	COG2095	MarC family integral membrane protein
ES965_RS17535	COG3064	Membrane
ES965_RS17540	COG4640	response to antibiotic
ES965_RS17545	COG0456	acetyltransferase
ES965_RS17550	COG0148	phosphopyruvate hydratase activity
ES965_RS17555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES965_RS17560	COG0149	triose-phosphate isomerase activity
ES965_RS17565	COG0126	phosphoglycerate kinase activity
ES965_RS17570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES965_RS17575	COG2390	Transcriptional regulator
ES965_RS17580	COG2814	Major facilitator Superfamily
ES965_RS17585	COG1609	Transcriptional regulator
ES965_RS17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS17600	COG0583	DNA-binding transcription factor activity
ES965_RS17605	COG0697	spore germination
ES965_RS17610	COG1113	amino acid transport
ES965_RS17615	COG3858	chitin binding
ES965_RS17620	COG1556	Lactate utilization protein
ES965_RS17625	COG1139	Iron-sulfur cluster binding protein
ES965_RS17630	COG0247	lactate metabolic process
ES965_RS17635	COG2197	response regulator
ES965_RS17640	COG4585	Histidine kinase
ES965_RS17645	COG0842	Transport permease protein
ES965_RS17650	COG1131	(ABC) transporter
ES965_RS17655	COG0596	Alpha beta hydrolase
ES965_RS17660	COG2208	phosphoserine phosphatase activity
ES965_RS17665	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES965_RS17670	COG1874	Beta-galactosidase
ES965_RS17675	COG3833	ABC-type maltose transport systems, permease component
ES965_RS17680	COG1175	transmembrane transport
ES965_RS17685	COG2182	Extracellular solute-binding protein
ES965_RS17690	COG1609	Transcriptional regulator
ES965_RS17695	COG2186	Transcriptional regulator
ES965_RS17700	COG1620	l-lactate permease
ES965_RS17705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES965_RS17715	COG5039	Polysaccharide pyruvyl transferase
ES965_RS17720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_RS17725	COG0110	maltose O-acetyltransferase activity
ES965_RS17730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES965_RS17735	COG2244	polysaccharide biosynthetic process
ES965_RS17740	COG1216	Glycosyl transferase, family 2
ES965_RS17745	COG5039	Polysaccharide pyruvyl transferase
ES965_RS17750	COG1216	Glycosyl transferase, family 2
ES965_RS17760	COG0438	transferase activity, transferring glycosyl groups
ES965_RS17765	COG1215	transferase activity, transferring glycosyl groups
ES965_RS17770	COG0438	transferase activity, transferring glycosyl groups
ES965_RS17775	COG1086	Polysaccharide biosynthesis protein
ES965_RS17780	COG0489	protein tyrosine kinase activity
ES965_RS17785	COG3944	biosynthesis protein
ES965_RS17790	COG1396	sequence-specific DNA binding
ES965_RS17795	COG2272	Belongs to the type-B carboxylesterase lipase family
ES965_RS17805	COG3479	Phenolic acid decarboxylase
ES965_RS17815	COG1794	racemase activity, acting on amino acids and derivatives
ES965_RS17820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_RS17830	COG1621	beta-fructofuranosidase activity
ES965_RS17835	COG1621	beta-fructofuranosidase activity
ES965_RS17840	COG0531	amino acid
ES965_RS17845	COG1309	transcriptional regulator
ES965_RS17850	COG2076	Multidrug Resistance protein
ES965_RS17855	COG2076	Multidrug Resistance protein
ES965_RS17865	COG3621	Patatin-like phospholipase
ES965_RS17875	COG0740	serine-type endopeptidase activity
ES965_RS17880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES965_RS17885	COG0366	Alpha amylase catalytic
ES965_RS17890	COG1554	hydrolase, family 65, central catalytic
ES965_RS17895	COG5521	maltodextrose utilization protein MalA
ES965_RS17900	COG3833	ABC-type maltose transport systems, permease component
ES965_RS17905	COG1175	transmembrane transport
ES965_RS17910	COG2182	Extracellular solute-binding protein
ES965_RS17915	COG0366	Alpha amylase catalytic
ES965_RS17920	COG1609	Transcriptional regulator
ES965_RS17925	COG1611	Belongs to the LOG family
ES965_RS17930	COG1694	Mazg nucleotide pyrophosphohydrolase
ES965_RS17935	COG0659	secondary active sulfate transmembrane transporter activity
ES965_RS17940	COG0288	reversible hydration of carbon dioxide
ES965_RS17945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES965_RS17950	COG0577	efflux transmembrane transporter activity
ES965_RS17955	COG1136	(ABC) transporter
ES965_RS17960	COG5002	protein histidine kinase activity
ES965_RS17965	COG0745	RESPONSE REGULATOR receiver
ES965_RS17975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES965_RS17980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS17985	COG1481	regulation of sporulation
ES965_RS17990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES965_RS17995	COG1660	Displays ATPase and GTPase activities
ES965_RS18000	COG1051	belongs to the nudix hydrolase family
ES965_RS18005	COG0492	ferredoxin-NADP+ reductase activity
ES965_RS18010	COG3883	PFAM NLP P60 protein
ES965_RS18010	COG0791	NLP P60 protein
ES965_RS18015	COG0457	Tetratricopeptide repeat
ES965_RS18020	COG1132	(ABC) transporter
ES965_RS18040	COG0140	phosphoribosyl-ATP diphosphatase activity
ES965_RS18040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES965_RS18045	COG0107	imidazoleglycerol-phosphate synthase activity
ES965_RS18050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES965_RS18055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES965_RS18060	COG0131	Imidazoleglycerol-phosphate dehydratase
ES965_RS18065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES965_RS18070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES965_RS18075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES965_RS18080	COG4990	cell redox homeostasis
ES965_RS18085	COG5297	Belongs to the glycosyl hydrolase family 6
ES965_RS18090	COG0110	maltose O-acetyltransferase activity
ES965_RS18095	COG0546	phosphoglycolate phosphatase activity
ES965_RS18100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES965_RS18105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES965_RS18110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES965_RS18115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES965_RS18120	COG0363	glucosamine-6-phosphate deaminase activity
ES965_RS18125	COG2188	Transcriptional regulator
ES965_RS18130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES965_RS18135	COG1950	PFAM Membrane protein of
ES965_RS18140	COG1983	PspC domain protein
ES965_RS18145	COG3595	metallopeptidase activity
ES965_RS18160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_RS18165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES965_RS18170	COG0556	nucleotide-excision repair
ES965_RS18175	COG4897	Protein conserved in bacteria
ES965_RS18180	COG3848	Pyruvate phosphate dikinase
ES965_RS18180	COG0574	Belongs to the PEP-utilizing enzyme family
ES965_RS18185	COG1309	transcriptional regulator
ES965_RS18190	COG2814	Major facilitator Superfamily
ES965_RS18195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_RS18205	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS18205	COG0793	Belongs to the peptidase S41A family
ES965_RS18210	COG2177	Part of the ABC transporter FtsEX involved in
ES965_RS18215	COG2884	Cell division ATP-binding protein ftsE
ES965_RS18220	COG2010	Cytochrome c
ES965_RS18225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS18235	COG0653	protein targeting
ES965_RS18240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES965_RS18255	COG1516	flagellar protein fliS
ES965_RS18260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES965_RS18265	COG1334	flagellar protein FlaG
ES965_RS18270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_RS18275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES965_RS18280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES965_RS18290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_RS18295	COG1256	bacterial-type flagellum assembly
ES965_RS18295	COG4786	Flagellar basal body rod
ES965_RS18300	COG3418	PFAM FlgN family protein
ES965_RS18305	COG2747	anti-sigma28 factor FlgM
ES965_RS18315	COG1040	competence protein
ES965_RS18325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES965_RS18330	COG1307	EDD domain protein, DegV family
ES965_RS18335	COG2197	response regulator
ES965_RS18340	COG4585	Histidine kinase
ES965_RS18345	COG1739	Uncharacterized protein family UPF0029
ES965_RS18350	COG1316	TRANSCRIPTIONal
ES965_RS18355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES965_RS18360	COG0438	transferase activity, transferring glycosyl groups
ES965_RS18365	COG1215	transferase activity, transferring glycosyl groups
ES965_RS18370	COG3206	protein involved in exopolysaccharide biosynthesis
ES965_RS18375	COG3307	-O-antigen
ES965_RS18380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_RS18385	COG0297	glycogen (starch) synthase activity
ES965_RS18385	COG0438	transferase activity, transferring glycosyl groups
ES965_RS18390	COG2244	polysaccharide biosynthetic process
ES965_RS18405	COG2247	cell wall binding repeat
ES965_RS18405	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_RS18410	COG2247	cell wall binding repeat
ES965_RS18410	COG2385	sporulation resulting in formation of a cellular spore
ES965_RS18420	COG1316	TRANSCRIPTIONal
ES965_RS18425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES965_RS18445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_RS18450	COG1134	teichoic acid transport
ES965_RS18455	COG1682	transport, permease protein
ES965_RS18470	COG1215	transferase activity, transferring glycosyl groups
ES965_RS18470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES965_RS18475	COG0463	Glycosyl transferase, family 2
ES965_RS18520	COG4193	domain, Protein
ES965_RS18525	COG1482	cell wall glycoprotein biosynthetic process
ES965_RS18530	COG0697	spore germination
ES965_RS18535	COG0814	amino acid
ES965_RS18545	COG2814	Major facilitator Superfamily
ES965_RS18550	COG1316	TRANSCRIPTIONal
ES965_RS18555	COG0561	phosphatase activity
ES965_RS18560	COG0791	NLP P60 protein
ES965_RS18570	COG2843	Capsule synthesis protein
ES965_RS18580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES965_RS18585	COG1609	Transcriptional regulator
ES965_RS18590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_RS18595	COG1869	D-ribose catabolic process
ES965_RS18600	COG1129	ABC transporter
ES965_RS18605	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES965_RS18610	COG1879	ABC-type sugar transport system periplasmic component
ES965_RS18615	COG3103	Sh3 type 3 domain protein
ES965_RS18625	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_RS18630	COG3527	Alpha-acetolactate decarboxylase
ES965_RS18635	COG0028	Belongs to the TPP enzyme family
ES965_RS18640	COG0583	DNA-binding transcription factor activity
ES965_RS18645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES965_RS18660	COG5337	Spore coat protein CotH
ES965_RS18670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES965_RS18680	COG0405	Gamma-glutamyltransferase
ES965_RS18685	COG1522	sequence-specific DNA binding
ES965_RS18690	COG2059	Chromate
ES965_RS18695	COG2059	Chromate
ES965_RS18705	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES965_RS18710	COG0583	DNA-binding transcription factor activity
ES965_RS18740	COG5444	nuclease activity
ES965_RS18755	COG3878	Protein conserved in bacteria
ES965_RS18760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_RS18765	COG4464	protein tyrosine phosphatase activity
ES965_RS18770	COG0489	protein tyrosine kinase activity
ES965_RS18775	COG3944	biosynthesis protein
ES965_RS18785	COG4715	Zinc finger, swim domain protein
ES965_RS18790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES965_RS18795	COG0561	phosphatase activity
ES965_RS18800	COG1349	DNA-binding transcription factor activity
ES965_RS18805	COG0629	single-stranded DNA binding
ES965_RS18820	COG3764	Sortase (surface protein transpeptidase)
ES965_RS18830	COG3279	Response regulator of the LytR AlgR family
ES965_RS18835	COG0745	RESPONSE REGULATOR receiver
ES965_RS18835	COG2972	Histidine kinase
ES965_RS18840	COG1970	mechanosensitive ion channel activity
ES965_RS18845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES965_RS18850	COG0457	Tetratricopeptide repeat
ES965_RS18855	COG4786	Flagellar basal body rod
ES965_RS18860	COG4786	Flagellar basal body rod
ES965_RS18865	COG1077	Cell shape determining protein MreB Mrl
ES965_RS18870	COG1609	Transcriptional regulator
ES965_RS18880	COG1846	Transcriptional regulator
ES965_RS18885	COG2814	Major facilitator Superfamily
ES965_RS18895	COG3420	alginic acid biosynthetic process
ES965_RS18900	COG1953	Uracil, thiamine, allantoin
ES965_RS18905	COG0477	Major facilitator Superfamily
ES965_RS18910	COG1335	isochorismatase
ES965_RS18920	COG0004	ammonium transporteR
ES965_RS18925	COG0347	Belongs to the P(II) protein family
ES965_RS18930	COG0671	phosphoesterase, PA-phosphatase related
ES965_RS18940	COG0739	heme binding
ES965_RS18945	COG1247	-acetyltransferase
ES965_RS18965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_RS18970	COG0789	Transcriptional regulator
ES965_RS18980	COG2910	NAD(P)H-binding
ES965_RS18985	COG1959	2 iron, 2 sulfur cluster binding
ES965_RS18990	COG0804	urea catabolic process
ES965_RS18995	COG0832	Belongs to the urease beta subunit family
ES965_RS19000	COG0831	urea catabolic process
ES965_RS19015	COG3237	CsbD-like
ES965_RS19020	COG1994	Peptidase M50
ES965_RS19025	COG0457	Tetratricopeptide repeat
ES965_RS19030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES965_RS19035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES965_RS19045	COG2304	oxidoreductase activity
ES965_RS19055	COG2304	oxidoreductase activity
ES965_RS19060	COG2385	sporulation resulting in formation of a cellular spore
ES965_RS19065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES965_RS19075	COG4836	Membrane
ES965_RS19085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES965_RS19090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES965_RS19095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES965_RS19100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES965_RS19105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES965_RS19110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES965_RS19120	COG0356	it plays a direct role in the translocation of protons across the membrane
ES965_RS19130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES965_RS19135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES965_RS19140	COG4475	Protein of unknown function (DUF436)
ES965_RS19145	COG0698	ribose 5-phosphate isomerase
ES965_RS19150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES965_RS19155	COG1971	Probably functions as a manganese efflux pump
ES965_RS19160	COG0009	L-threonylcarbamoyladenylate synthase
ES965_RS19165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES965_RS19185	COG2890	protein-(glutamine-N5) methyltransferase activity
ES965_RS19190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES965_RS19195	COG0346	lactoylglutathione lyase activity
ES965_RS19200	COG0789	Transcriptional regulator
ES965_RS19205	COG0679	Auxin Efflux Carrier
ES965_RS19210	COG0281	malic enzyme
ES965_RS19215	COG1435	thymidine kinase activity
ES965_RS19225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES965_RS19235	COG1494	fructose-1,6-bisphosphatase
ES965_RS19240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES965_RS19245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES965_RS19250	COG0191	fructose-bisphosphate aldolase activity
ES965_RS19255	COG2204	response regulator
ES965_RS19260	COG4821	SIS domain
ES965_RS19265	COG0504	CTP synthase activity
ES965_RS19270	COG3343	RNA polymerase activity
ES965_RS19275	COG1960	acyl-CoA dehydrogenase activity
ES965_RS19280	COG0247	lactate metabolic process
ES965_RS19280	COG2181	nitrate reductase activity
ES965_RS19285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_RS19290	COG4294	response to UV
ES965_RS19300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES965_RS19305	COG1132	(ABC) transporter
ES965_RS19310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_RS19320	COG2181	nitrate reductase activity
ES965_RS19325	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES965_RS19330	COG1140	nitrate reductase beta subunit
ES965_RS19335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES965_RS19340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES965_RS19350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES965_RS19355	COG2223	nitrite transmembrane transporter activity
ES965_RS19360	COG0018	arginyl-trna synthetase
ES965_RS19365	COG4506	Protein conserved in bacteria
ES965_RS19380	COG0535	radical SAM domain protein
ES965_RS19390	COG1131	(ABC) transporter
ES965_RS19395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES965_RS19400	COG0612	Peptidase, M16
ES965_RS19405	COG0612	Peptidase, M16
ES965_RS19415	COG3391	amine dehydrogenase activity
ES965_RS19420	COG3391	amine dehydrogenase activity
ES965_RS19430	COG0457	Tetratricopeptide repeat
ES965_RS19460	COG1131	(ABC) transporter
ES965_RS19470	COG0010	Belongs to the arginase family
ES965_RS19475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES965_RS19480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_RS19495	COG1994	Peptidase M50
ES965_RS19500	COG1942	4-Oxalocrotonate Tautomerase
ES965_RS19505	COG1846	Transcriptional regulator
ES965_RS19510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES965_RS19520	COG0477	Major facilitator Superfamily
ES965_RS19525	COG1959	2 iron, 2 sulfur cluster binding
ES965_RS19530	COG3465	dGTPase activity
ES965_RS19535	COG1078	dGTPase activity
ES965_RS19540	COG4844	belongs to the
ES965_RS19550	COG0697	spore germination
ES965_RS19555	COG0095	Lipoate-protein ligase
ES965_RS19560	COG0583	DNA-binding transcription factor activity
ES965_RS19565	COG0280	phosphate acetyltransferase
ES965_RS19570	COG3253	May function as heme-dependent peroxidase
ES965_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS19580	COG0436	Aminotransferase
ES965_RS19585	COG2814	Major facilitator Superfamily
ES965_RS19590	COG0151	Belongs to the GarS family
ES965_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS19600	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS19605	COG0077	Prephenate dehydratase
ES965_RS19610	COG2814	Major facilitator Superfamily
ES965_RS19615	COG0833	amino acid
ES965_RS19620	COG4187	Peptidase family M20/M25/M40
ES965_RS19625	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS19630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_RS19640	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES965_RS19645	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES965_RS19650	COG1088	dTDP-glucose 4,6-dehydratase activity
ES965_RS19655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES965_RS19660	COG3980	spore coat polysaccharide biosynthesis protein
ES965_RS19665	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES965_RS19670	COG2089	acid synthase
ES965_RS19675	COG0456	acetyltransferase
ES965_RS19680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_RS19685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES965_RS19690	COG0463	Glycosyl transferase, family 2
ES965_RS19705	COG2363	Small membrane protein
ES965_RS19710	COG2233	PERMEase
ES965_RS19720	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS19725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES965_RS19730	COG1216	Glycosyl transferase, family 2
ES965_RS19735	COG0351	phosphomethylpyrimidine kinase
ES965_RS19745	COG1621	beta-fructofuranosidase activity
ES965_RS19750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS19750	COG1263	PTS System
ES965_RS19755	COG2116	formate transmembrane transporter activity
ES965_RS19760	COG3711	transcriptional antiterminator
ES965_RS19770	COG1404	Belongs to the peptidase S8 family
ES965_RS19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS19780	COG0778	Nitroreductase
ES965_RS19785	COG0772	Belongs to the SEDS family
ES965_RS19795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES965_RS19800	COG1845	cytochrome c oxidase, subunit III
ES965_RS19805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES965_RS19810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES965_RS19815	COG2261	transglycosylase associated protein
ES965_RS19820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES965_RS19825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES965_RS19830	COG2246	polysaccharide biosynthetic process
ES965_RS19835	COG1309	transcriptional regulator
ES965_RS19845	COG3162	membrane
ES965_RS19850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_RS19855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES965_RS19860	COG2837	iron assimilation
ES965_RS19865	COG2822	iron ion transport
ES965_RS19870	COG0672	)-iron permease
ES965_RS19875	COG0352	thiamine-phosphate diphosphorylase activity
ES965_RS19880	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES965_RS19885	COG0583	DNA-binding transcription factor activity
ES965_RS19890	COG1380	Effector of murein hydrolase LrgA
ES965_RS19895	COG1346	cytolysis
ES965_RS19900	COG2814	Major facilitator Superfamily
ES965_RS19905	COG4895	conserved protein (DUF2196)
ES965_RS19910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES965_RS19915	COG0346	lactoylglutathione lyase activity
ES965_RS19925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_RS19930	COG1404	Belongs to the peptidase S8 family
ES965_RS19935	COG1263	PTS System
ES965_RS19935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS19940	COG3711	transcriptional antiterminator
ES965_RS19945	COG1442	glycosyl transferase family 8
ES965_RS19950	COG5522	Integral membrane protein (intg_mem_TP0381)
ES965_RS19955	COG1846	Transcriptional regulator
ES965_RS19960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES965_RS19965	COG2234	aminopeptidase activity
ES965_RS19980	COG2814	Major facilitator Superfamily
ES965_RS19985	COG2357	RelA SpoT domain protein
ES965_RS19990	COG1575	Belongs to the MenA family. Type 1 subfamily
ES965_RS20010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_RS20015	COG1696	Membrane protein involved in D-alanine export
ES965_RS20020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_RS20025	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES965_RS20030	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ES965_RS20035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_RS20040	COG1486	melibiose metabolic process
ES965_RS20045	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES965_RS20050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_RS20055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_RS20060	COG3711	transcriptional antiterminator
ES965_RS20060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_RS20070	COG2094	Belongs to the DNA glycosylase MPG family
ES965_RS20075	COG0753	catalase activity
ES965_RS20080	COG2814	Major facilitator Superfamily
ES965_RS20085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_RS20090	COG1131	(ABC) transporter
ES965_RS20110	COG1595	DNA-templated transcription, initiation
ES965_RS20115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES965_RS20120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES965_RS20125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES965_RS20130	COG4988	ABC transporter
ES965_RS20135	COG1294	oxidase, subunit
ES965_RS20140	COG1271	oxidase subunit
ES965_RS20145	COG3493	citrate carrier protein
ES965_RS20150	COG0501	Belongs to the peptidase M48B family
ES965_RS20160	COG0726	polysaccharide deacetylase
ES965_RS20165	COG3842	ATPase activity
ES965_RS20170	COG2508	Transcriptional regulator
ES965_RS20175	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS20180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_RS20190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES965_RS20200	COG4585	Histidine kinase
ES965_RS20205	COG2197	response regulator
ES965_RS20210	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES965_RS20220	COG4894	glucomannan catabolic process
ES965_RS20225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_RS20230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS20240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES965_RS20245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES965_RS20250	COG2610	gluconate transmembrane transporter activity
ES965_RS20255	COG0500	methyltransferase
ES965_RS20260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_RS20275	COG0753	catalase activity
ES965_RS20275	COG0693	protein deglycase activity
ES965_RS20280	COG2851	Citrate transporter
ES965_RS20285	COG2273	Hydrolase Family 16
ES965_RS20290	COG3711	transcriptional antiterminator
ES965_RS20300	COG2270	Major facilitator Superfamily
ES965_RS20305	COG0513	Belongs to the DEAD box helicase family
ES965_RS20310	COG2755	lipolytic protein G-D-S-L family
ES965_RS20310	COG3401	FG-GAP repeat protein
ES965_RS20345	COG0697	spore germination
ES965_RS20350	COG0589	response to stress
ES965_RS20355	COG2723	6-phospho-beta-galactosidase activity
ES965_RS20360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS20360	COG2190	(PTS) system
ES965_RS20360	COG1263	PTS System
ES965_RS20370	COG5444	nuclease activity
ES965_RS20405	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_RS20430	COG2986	histidine ammonia-lyase
ES965_RS20435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ES965_RS20440	COG1228	amidohydrolase
ES965_RS20445	COG0010	Belongs to the arginase family
ES965_RS20450	COG0833	amino acid
ES965_RS20455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES965_RS20460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_RS20465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES965_RS20470	COG2390	Transcriptional regulator
ES965_RS20480	COG3192	ethanolamine utilization protein
ES965_RS20485	COG2079	MmgE PrpD family protein
ES965_RS20490	COG1473	amidohydrolase
ES965_RS20495	COG1126	abc transporter atp-binding protein
ES965_RS20500	COG0765	amino acid transport
ES965_RS20505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_RS20510	COG0456	acetyltransferase
ES965_RS20515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_RS20525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES965_RS20530	COG0561	phosphatase activity
ES965_RS20560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_RS20565	COG5294	Protein conserved in bacteria
ES965_RS20570	COG0577	efflux transmembrane transporter activity
ES965_RS20575	COG1136	(ABC) transporter
ES965_RS20580	COG2205	protein histidine kinase activity
ES965_RS20585	COG0745	RESPONSE REGULATOR receiver
ES965_RS20590	COG0191	fructose-bisphosphate aldolase activity
ES965_RS20595	COG1082	Xylose isomerase domain protein TIM barrel
ES965_RS20600	COG1082	Xylose isomerase domain protein TIM barrel
ES965_RS20605	COG0673	inositol 2-dehydrogenase activity
ES965_RS20610	COG2814	Major facilitator Superfamily
ES965_RS20615	COG1082	Xylose isomerase domain protein TIM barrel
ES965_RS20620	COG3962	Belongs to the TPP enzyme family
ES965_RS20625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_RS20635	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS20640	COG1349	DNA-binding transcription factor activity
ES965_RS20645	COG0667	Aldo Keto reductase
ES965_RS20670	COG2814	Major facilitator Superfamily
ES965_RS20675	COG0326	Molecular chaperone. Has ATPase activity
ES965_RS20685	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS20690	COG1309	transcriptional regulator
ES965_RS20695	COG1012	belongs to the aldehyde dehydrogenase family
ES965_RS20705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ES965_RS20715	COG1714	RDD family
ES965_RS20720	COG2311	Membrane
ES965_RS20725	COG1917	Cupin 2, conserved barrel domain protein
ES965_RS20730	COG1309	transcriptional regulator
ES965_RS20735	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_RS20740	COG1846	Transcriptional regulator
ES965_RS20745	COG1380	Effector of murein hydrolase LrgA
ES965_RS20750	COG1346	cytolysis
ES965_RS20755	COG5039	Polysaccharide pyruvyl transferase
ES965_RS20760	COG1929	Belongs to the glycerate kinase type-1 family
ES965_RS20765	COG1802	Transcriptional regulator
ES965_RS20770	COG1070	Carbohydrate kinase
ES965_RS20775	COG2610	gluconate transmembrane transporter activity
ES965_RS20780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES965_RS20785	COG0450	alkyl hydroperoxide reductase
ES965_RS20790	COG3634	alkyl hydroperoxide reductase activity
ES965_RS20800	COG2723	6-phospho-beta-galactosidase activity
ES965_RS20805	COG2190	(PTS) system
ES965_RS20810	COG1263	PTS System
ES965_RS20810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_RS20815	COG2188	Transcriptional regulator
ES965_RS20830	COG1131	(ABC) transporter
ES965_RS20835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES965_RS20850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES965_RS20865	COG1063	alcohol dehydrogenase
ES965_RS20885	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES965_RS20890	COG0456	acetyltransferase
ES965_RS20895	COG0457	Tetratricopeptide repeat
ES965_RS20905	COG0010	Belongs to the arginase family
ES965_RS20910	COG0833	amino acid
ES965_RS20915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES965_RS20920	COG3829	transcription factor binding
ES965_RS20925	COG5002	protein histidine kinase activity
ES965_RS20930	COG0745	RESPONSE REGULATOR receiver
ES965_RS20950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_RS20955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES965_RS20960	COG4853	Protein conserved in bacteria
ES965_RS20965	COG4863	YycH protein
ES965_RS20970	COG5002	protein histidine kinase activity
ES965_RS20975	COG0745	RESPONSE REGULATOR receiver
ES965_RS21005	COG0346	lactoylglutathione lyase activity
ES965_RS21010	COG0305	Participates in initiation and elongation during chromosome replication
ES965_RS21025	COG3093	addiction module antidote protein HigA
ES965_RS21030	COG2807	transmembrane transport
ES965_RS21035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES965_RS21040	COG0359	binds to the 23S rRNA
ES965_RS21045	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES965_RS21050	COG4241	membrane
ES965_RS21060	COG5577	PFAM Coat F domain
ES965_RS21065	COG1733	regulation of RNA biosynthetic process
ES965_RS21070	COG1227	inorganic diphosphatase activity
ES965_RS21080	COG2271	Major facilitator Superfamily
ES965_RS21085	COG0789	Transcriptional regulator
ES965_RS21085	COG4978	Transcriptional regulator
ES965_RS21095	COG4319	ketosteroid isomerase
ES965_RS21100	COG1357	PFAM Pentapeptide repeats (8 copies)
ES965_RS21105	COG2814	Major facilitator Superfamily
ES965_RS21110	COG0583	DNA-binding transcription factor activity
ES965_RS21115	COG2153	protein acetylation
ES965_RS21130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_RS21135	COG1846	Transcriptional regulator
ES965_RS21140	COG2153	protein acetylation
ES965_RS21145	COG2364	Membrane
ES965_RS21155	COG1331	Highly conserved protein containing a thioredoxin domain
ES965_RS21170	COG0640	Transcriptional regulator
ES965_RS21180	COG0789	Transcriptional regulator
ES965_RS21185	COG0697	spore germination
ES965_RS21190	COG1331	Highly conserved protein containing a thioredoxin domain
ES965_RS21195	COG1266	CAAX protease self-immunity
ES965_RS21200	COG2814	Major facilitator Superfamily
ES965_RS21200	COG0477	Major facilitator Superfamily
ES965_RS21205	COG0110	maltose O-acetyltransferase activity
ES965_RS21210	COG0346	lactoylglutathione lyase activity
ES965_RS21215	COG1609	Transcriptional regulator
ES965_RS21220	COG0708	Exodeoxyribonuclease III
ES965_RS21225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES965_RS21230	COG0629	single-stranded DNA binding
ES965_RS21235	COG0360	Binds together with S18 to 16S ribosomal RNA
ES965_RS21240	COG0012	GTP binding
ES965_RS21245	COG0243	molybdopterin cofactor binding
ES965_RS21250	COG4481	Protein conserved in bacteria
ES965_RS21255	COG3949	Membrane
ES965_RS21265	COG1475	DNA binding
ES965_RS21270	COG1192	Involved in chromosome partitioning
ES965_RS21280	COG1475	DNA binding
ES965_RS21285	COG0357	Ribosomal RNA small subunit methyltransferase G
ES965_RS21290	COG0445	tRNA wobble uridine modification
ES965_RS21295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES965_RS21300	COG1847	R3H domain protein
ES965_RS21305	COG0706	membrane insertase activity
ES965_RS21310	COG0594	ribonuclease P activity
ES965_RS21330	COG5280	Phage tail tape measure protein TP901
ES965_RS21330	COG3953	SLT domain
ES965_RS21365	COG1388	LysM domain
ES965_RS21365	COG3409	Peptidoglycan-binding domain 1 protein
ES965_RS21365	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_RS21395	COG1674	ftsk spoiiie
ES965_RS21460	COG1484	DNA-dependent DNA replication