locus-tag	class	description
ES968_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES968_RS00010	COG0592	DNA-directed DNA polymerase activity
ES968_RS00015	COG2501	S4 domain
ES968_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES968_RS00030	COG0187	DNA topoisomerase II activity
ES968_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES968_RS00070	COG0516	GMP reductase activity
ES968_RS00070	COG0517	IMP dehydrogenase activity
ES968_RS00075	COG1686	Belongs to the peptidase S11 family
ES968_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES968_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES968_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES968_RS00100	COG1428	Deoxynucleoside kinase
ES968_RS00105	COG1428	Deoxynucleoside kinase
ES968_RS00110	COG1388	LysM domain
ES968_RS00110	COG3858	chitin binding
ES968_RS00115	COG1335	isochorismatase
ES968_RS00120	COG0590	tRNA wobble adenosine to inosine editing
ES968_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES968_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES968_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES968_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES968_RS00190	COG3853	Toxic anion resistance protein (TelA)
ES968_RS00195	COG1982	Orn Lys Arg decarboxylase major
ES968_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES968_RS00205	COG3870	Protein conserved in bacteria
ES968_RS00210	COG1728	Protein conserved in bacteria
ES968_RS00215	COG0470	DNA polymerase III
ES968_RS00220	COG1774	PSP1 C-terminal conserved region
ES968_RS00225	COG4467	Involved in initiation control of chromosome replication
ES968_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES968_RS00235	COG2827	Endonuclease containing a URI domain
ES968_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES968_RS00245	COG2002	toxin-antitoxin pair type II binding
ES968_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_RS00255	COG0084	hydrolase, TatD family'
ES968_RS00260	COG3583	domain protein
ES968_RS00260	COG3584	3D domain protein
ES968_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES968_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES968_RS00280	COG4466	Protein conserved in bacteria
ES968_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES968_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_RS00300	COG0251	oxidation-reduction process
ES968_RS00305	COG2088	sporulation resulting in formation of a cellular spore
ES968_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES968_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES968_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES968_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
ES968_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES968_RS00340	COG2002	toxin-antitoxin pair type II binding
ES968_RS00345	COG2244	polysaccharide biosynthetic process
ES968_RS00350	COG3956	TIGRFAM MazG family protein
ES968_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES968_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES968_RS00375	COG1098	S1 RNA binding domain
ES968_RS00390	COG2208	phosphoserine phosphatase activity
ES968_RS00395	COG2304	oxidoreductase activity
ES968_RS00400	COG0515	serine threonine protein kinase
ES968_RS00405	COG0037	tRNA processing
ES968_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ES968_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES968_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES968_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES968_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES968_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES968_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ES968_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES968_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES968_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES968_RS00470	COG1396	sequence-specific DNA binding
ES968_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES968_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES968_RS00560	COG4463	regulation of RNA biosynthetic process
ES968_RS00565	COG3880	PFAM UvrB UvrC protein
ES968_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES968_RS00575	COG0542	response to heat
ES968_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES968_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES968_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
ES968_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES968_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES968_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES968_RS00615	COG1045	serine acetyltransferase
ES968_RS00620	COG0215	cysteine-tRNA ligase activity
ES968_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES968_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES968_RS00635	COG3688	RNA-binding protein containing a PIN domain
ES968_RS00640	COG1595	DNA-templated transcription, initiation
ES968_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES968_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
ES968_RS00665	COG0081	regulation of translation
ES968_RS00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES968_RS00680	COG2813	Specifically methylates the guanine in position
ES968_RS00685	COG0085	RNA polymerase activity
ES968_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES968_RS00695	COG1358	cellular component organization or biogenesis
ES968_RS00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES968_RS00705	COG0049	tRNA binding
ES968_RS00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES968_RS00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES968_RS00720	COG0596	Alpha beta hydrolase
ES968_RS00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES968_RS00735	COG0088	Forms part of the polypeptide exit tunnel
ES968_RS00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES968_RS00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES968_RS00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES968_RS00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES968_RS00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES968_RS00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES968_RS00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES968_RS00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES968_RS00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES968_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES968_RS00825	COG0200	Binds to the 23S rRNA
ES968_RS00830	COG0201	protein transport
ES968_RS00835	COG0563	adenylate kinase activity
ES968_RS00840	COG0024	Methionine aminopeptidase
ES968_RS00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES968_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES968_RS00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES968_RS00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES968_RS00870	COG0202	RNA polymerase activity
ES968_RS00875	COG0203	ribosomal protein L17
ES968_RS00880	COG1122	ATPase activity
ES968_RS00885	COG1122	ATPase activity
ES968_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES968_RS00895	COG0101	tRNA pseudouridine synthase activity
ES968_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES968_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES968_RS00910	COG2226	methyltransferase
ES968_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS00925	COG0489	protein tyrosine kinase activity
ES968_RS00935	COG2194	sulfuric ester hydrolase activity
ES968_RS00940	COG0726	polysaccharide deacetylase
ES968_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
ES968_RS01035	COG0385	Bile acid
ES968_RS01040	COG2819	hydrolase of the alpha beta superfamily
ES968_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS01060	COG2207	Transcriptional regulator
ES968_RS01065	COG3876	Protein conserved in bacteria
ES968_RS01070	COG1472	Belongs to the glycosyl hydrolase 3 family
ES968_RS01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES968_RS01080	COG1263	PTS System
ES968_RS01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS01085	COG1737	Transcriptional regulator
ES968_RS01090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES968_RS01095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS01100	COG1683	Conserved Protein
ES968_RS01130	COG1595	DNA-templated transcription, initiation
ES968_RS01135	COG5662	AntiSigma factor
ES968_RS01140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES968_RS01145	COG4856	YbbR-like protein
ES968_RS01150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES968_RS01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES968_RS01190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES968_RS01195	COG3002	Belongs to the UPF0753 family
ES968_RS01200	COG0288	reversible hydration of carbon dioxide
ES968_RS01210	COG5609	conserved protein (DUF2294)
ES968_RS01230	COG0515	serine threonine protein kinase
ES968_RS01245	COG1113	amino acid transport
ES968_RS01260	COG2602	Beta-lactamase
ES968_RS01265	COG2124	cytochrome p450
ES968_RS01275	COG0531	amino acid
ES968_RS01280	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_RS01285	COG2271	Major facilitator Superfamily
ES968_RS01300	COG0456	acetyltransferase
ES968_RS01300	COG1846	Transcriptional regulator
ES968_RS01320	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS01325	COG0697	spore germination
ES968_RS01330	COG2207	Transcriptional regulator
ES968_RS01330	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES968_RS01360	COG3591	Belongs to the peptidase S1B family
ES968_RS01370	COG0596	Alpha beta hydrolase
ES968_RS01375	COG1183	phosphatidylcholine synthase activity
ES968_RS01380	COG0586	Pfam SNARE associated Golgi protein
ES968_RS01385	COG0688	phosphatidylethanolamine metabolic process
ES968_RS01395	COG2312	Erythromycin esterase
ES968_RS01400	COG2207	Transcriptional regulator
ES968_RS01405	COG1054	Belongs to the UPF0176 family
ES968_RS01410	COG1301	dicarboxylic acid transport
ES968_RS01415	COG2190	(PTS) system
ES968_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS01415	COG1263	PTS System
ES968_RS01420	COG0363	glucosamine-6-phosphate deaminase activity
ES968_RS01425	COG2188	Transcriptional regulator
ES968_RS01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_RS01440	COG0833	amino acid
ES968_RS01445	COG2040	homocysteine
ES968_RS01455	COG1115	amino acid carrier protein
ES968_RS01460	COG2066	Belongs to the glutaminase family
ES968_RS01465	COG4191	Histidine kinase
ES968_RS01470	COG0784	Response regulator, receiver
ES968_RS01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES968_RS01485	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS01490	COG2271	Major facilitator Superfamily
ES968_RS01495	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_RS01500	COG2186	Transcriptional regulator
ES968_RS01520	COG0697	spore germination
ES968_RS01525	COG0745	RESPONSE REGULATOR receiver
ES968_RS01530	COG2205	protein histidine kinase activity
ES968_RS01535	COG1131	(ABC) transporter
ES968_RS01555	COG3773	Cell wall hydrolase
ES968_RS01560	COG2304	oxidoreductase activity
ES968_RS01570	COG3540	Alkaline phosphatase
ES968_RS01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_RS01580	COG0805	protein transport
ES968_RS01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES968_RS01590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES968_RS01595	COG0477	Major facilitator Superfamily
ES968_RS01600	COG1309	transcriptional regulator
ES968_RS01605	COG0252	asparaginase activity
ES968_RS01610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES968_RS01615	COG1714	RDD family
ES968_RS01620	COG3012	SEC-C Motif Domain Protein
ES968_RS01620	COG1405	negative regulation of cell septum assembly
ES968_RS01635	COG3279	Response regulator of the LytR AlgR family
ES968_RS01640	COG4555	ABC transporter
ES968_RS01645	COG1668	transmembrane transport
ES968_RS01650	COG0667	Aldo Keto reductase
ES968_RS01665	COG1595	DNA-templated transcription, initiation
ES968_RS01670	COG1595	DNA-templated transcription, initiation
ES968_RS01675	COG1876	peptidase activity
ES968_RS01680	COG0457	Tetratricopeptide repeat
ES968_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS01690	COG0366	Alpha amylase catalytic
ES968_RS01695	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES968_RS01700	COG1121	(ABC) transporter
ES968_RS01705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_RS01715	COG2310	stress, protein
ES968_RS01720	COG2310	stress, protein
ES968_RS01725	COG2310	stress, protein
ES968_RS01730	COG0861	Integral membrane protein TerC family
ES968_RS01740	COG3853	Toxic anion resistance protein (TelA)
ES968_RS01745	COG0477	Major facilitator Superfamily
ES968_RS01750	COG2814	Major facilitator Superfamily
ES968_RS01755	COG0640	Transcriptional regulator
ES968_RS01760	COG0517	IMP dehydrogenase activity
ES968_RS01760	COG4175	Glycine betaine
ES968_RS01765	COG4176	ABC-type proline glycine betaine transport system permease component
ES968_RS01770	COG2113	Glycine betaine
ES968_RS01775	COG1473	amidohydrolase
ES968_RS01780	COG1288	antiporter activity
ES968_RS01790	COG0366	Alpha amylase catalytic
ES968_RS01795	COG0039	L-malate dehydrogenase activity
ES968_RS01810	COG3403	YqcI/YcgG family
ES968_RS01820	COG3665	Urea carboxylase-associated protein
ES968_RS01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES968_RS01830	COG1660	Displays ATPase and GTPase activities
ES968_RS01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES968_RS01845	COG2226	methyltransferase
ES968_RS01850	COG0583	DNA-binding transcription factor activity
ES968_RS01855	COG3458	cephalosporin-C deacetylase activity
ES968_RS01860	COG3541	Predicted nucleotidyltransferase
ES968_RS01865	COG0506	proline dehydrogenase activity
ES968_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_RS01880	COG2508	Transcriptional regulator
ES968_RS01885	COG3689	TIGRFAM TIGR03943 family protein
ES968_RS01890	COG0701	Predicted permease
ES968_RS01895	COG2267	carboxylic ester hydrolase activity
ES968_RS01900	COG0492	ferredoxin-NADP+ reductase activity
ES968_RS01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES968_RS01905	COG1587	Uroporphyrinogen-III synthase
ES968_RS01910	COG2146	nitrite reductase [NAD(P)H] activity
ES968_RS01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_RS01920	COG0243	molybdopterin cofactor binding
ES968_RS01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_RS01930	COG2223	nitrite transmembrane transporter activity
ES968_RS01935	COG1469	GTP cyclohydrolase I activity
ES968_RS01940	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_RS01950	COG0523	cobalamin synthesis protein
ES968_RS01955	COG0765	amino acid transport
ES968_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_RS01980	COG1846	Transcriptional regulator
ES968_RS01990	COG3842	ATPase activity
ES968_RS01995	COG2723	6-phospho-beta-galactosidase activity
ES968_RS02005	COG3209	COG3209 Rhs family protein
ES968_RS02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES968_RS02020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES968_RS02025	COG1733	regulation of RNA biosynthetic process
ES968_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES968_RS02050	COG2814	Major facilitator Superfamily
ES968_RS02060	COG0697	spore germination
ES968_RS02080	COG2364	Membrane
ES968_RS02085	COG1126	abc transporter atp-binding protein
ES968_RS02090	COG0765	amino acid transport
ES968_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_RS02100	COG0583	DNA-binding transcription factor activity
ES968_RS02110	COG0596	Alpha beta hydrolase
ES968_RS02115	COG3104	oligopeptide transport
ES968_RS02120	COG5434	Belongs to the glycosyl hydrolase 28 family
ES968_RS02130	COG0697	spore germination
ES968_RS02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES968_RS02145	COG1136	(ABC) transporter
ES968_RS02150	COG0577	efflux transmembrane transporter activity
ES968_RS02155	COG0745	RESPONSE REGULATOR receiver
ES968_RS02160	COG3850	Histidine kinase
ES968_RS02160	COG5002	protein histidine kinase activity
ES968_RS02165	COG0457	Tetratricopeptide repeat
ES968_RS02185	COG0527	aspartate kinase activity
ES968_RS02190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS02195	COG4605	iron ion homeostasis
ES968_RS02200	COG4604	ABC transporter, ATP-binding protein
ES968_RS02205	COG4607	ABC-type enterochelin transport system periplasmic component
ES968_RS02215	COG2814	Major facilitator Superfamily
ES968_RS02220	COG1309	transcriptional regulator
ES968_RS02225	COG0778	Nitroreductase
ES968_RS02230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES968_RS02235	COG0640	Transcriptional regulator
ES968_RS02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS02245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES968_RS02250	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS02255	COG4975	Glucose uptake
ES968_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS02265	COG4549	nuclear export factor GLE1
ES968_RS02270	COG2372	response to copper ion
ES968_RS02270	COG1276	copper resistance
ES968_RS02275	COG1349	DNA-binding transcription factor activity
ES968_RS02285	COG2213	PTS system mannitol-specific
ES968_RS02290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS02295	COG0246	Mannitol dehydrogenase
ES968_RS02300	COG0473	3-isopropylmalate dehydrogenase activity
ES968_RS02305	COG0681	Belongs to the peptidase S26 family
ES968_RS02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES968_RS02325	COG0561	phosphatase activity
ES968_RS02330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES968_RS02335	COG1914	H( )-stimulated, divalent metal cation uptake system
ES968_RS02340	COG4336	lyase activity
ES968_RS02345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES968_RS02350	COG1984	allophanate hydrolase subunit 2
ES968_RS02355	COG1414	Transcriptional regulator
ES968_RS02360	COG2755	lipolytic protein G-D-S-L family
ES968_RS02370	COG2329	Antibiotic biosynthesis monooxygenase
ES968_RS02375	COG0768	penicillin binding
ES968_RS02380	COG4989	oxidoreductase activity
ES968_RS02385	COG3711	transcriptional antiterminator
ES968_RS02390	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS02395	COG2226	methyltransferase
ES968_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS02405	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS02410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS02415	COG3871	stress protein (general stress protein 26)
ES968_RS02425	COG2814	Major facilitator Superfamily
ES968_RS02430	COG1522	sequence-specific DNA binding
ES968_RS02435	COG0551	DNA topoisomerase type I activity
ES968_RS02435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES968_RS02440	COG0494	nUDIX hydrolase
ES968_RS02445	COG0028	Belongs to the TPP enzyme family
ES968_RS02475	COG1914	H( )-stimulated, divalent metal cation uptake system
ES968_RS02480	COG2261	transglycosylase associated protein
ES968_RS02485	COG4876	unkown
ES968_RS02490	COG2217	Heavy metal translocating P-type atpase
ES968_RS02495	COG3729	General stress protein
ES968_RS02500	COG0662	Cupin 2, conserved barrel domain protein
ES968_RS02505	COG2329	Antibiotic biosynthesis monooxygenase
ES968_RS02515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES968_RS02520	COG3290	protein histidine kinase activity
ES968_RS02525	COG4565	transcriptional regulatory protein
ES968_RS02530	COG1301	dicarboxylic acid transport
ES968_RS02535	COG0628	permease
ES968_RS02540	COG1131	(ABC) transporter
ES968_RS02545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_RS02555	COG1960	acyl-CoA dehydrogenase activity
ES968_RS02570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_RS02575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES968_RS02585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES968_RS02595	COG0513	Belongs to the DEAD box helicase family
ES968_RS02600	COG3402	PFAM membrane-flanked domain
ES968_RS02605	COG3428	Bacterial PH domain
ES968_RS02610	COG0705	Rhomboid family
ES968_RS02615	COG0736	holo-[acyl-carrier-protein] synthase activity
ES968_RS02620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES968_RS02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES968_RS02630	COG0864	Transcriptional regulator
ES968_RS02635	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES968_RS02640	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS02650	COG2172	sigma factor antagonist activity
ES968_RS02655	COG2208	phosphoserine phosphatase activity
ES968_RS02660	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS02665	COG2172	sigma factor antagonist activity
ES968_RS02670	COG1191	sigma factor activity
ES968_RS02675	COG2208	phosphoserine phosphatase activity
ES968_RS02680	COG2183	response to ionizing radiation
ES968_RS02690	COG3091	SprT-like family
ES968_RS02740	COG0583	DNA-binding transcription factor activity
ES968_RS02745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS02755	COG5444	nuclease activity
ES968_RS02765	COG1476	TRANSCRIPTIONal
ES968_RS02790	COG0693	protein deglycase activity
ES968_RS02795	COG1278	Cold shock
ES968_RS02800	COG1329	Transcriptional regulator
ES968_RS02810	COG0697	spore germination
ES968_RS02815	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS02815	COG2207	Transcriptional regulator
ES968_RS02820	COG0697	spore germination
ES968_RS02825	COG2207	Transcriptional regulator
ES968_RS02825	COG3708	Transcriptional regulator
ES968_RS02830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS02835	COG0477	Major facilitator Superfamily
ES968_RS02845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES968_RS02860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS02865	COG1309	transcriptional regulator
ES968_RS02870	COG0697	spore germination
ES968_RS02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS02880	COG2030	dehydratase
ES968_RS02885	COG3545	Serine hydrolase
ES968_RS02890	COG1733	regulation of RNA biosynthetic process
ES968_RS02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS02900	COG0640	Transcriptional regulator
ES968_RS02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES968_RS02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS02920	COG0697	spore germination
ES968_RS02925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS02930	COG0076	glutamate decarboxylase activity
ES968_RS02935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES968_RS02940	COG0640	Transcriptional regulator
ES968_RS02945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES968_RS02960	COG4585	Histidine kinase
ES968_RS02965	COG2197	response regulator
ES968_RS02970	COG2409	Drug exporters of the RND superfamily
ES968_RS02975	COG0596	Alpha beta hydrolase
ES968_RS02980	COG1811	Na channel or pump
ES968_RS02985	COG0789	Transcriptional regulator
ES968_RS02985	COG4978	Transcriptional regulator
ES968_RS02990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_RS02995	COG0778	Nitroreductase
ES968_RS03000	COG0346	lactoylglutathione lyase activity
ES968_RS03005	COG2259	Doxx family
ES968_RS03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS03025	COG2323	membrane
ES968_RS03030	COG2323	membrane
ES968_RS03035	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_RS03050	COG1309	transcriptional regulator
ES968_RS03060	COG0456	acetyltransferase
ES968_RS03065	COG0488	(ABC) transporter
ES968_RS03070	COG1113	amino acid transport
ES968_RS03075	COG2318	DinB family
ES968_RS03080	COG1846	Transcriptional regulator
ES968_RS03085	COG1033	growth of symbiont in host cell
ES968_RS03085	COG2409	Drug exporters of the RND superfamily
ES968_RS03090	COG0778	Nitroreductase
ES968_RS03095	COG1846	Transcriptional regulator
ES968_RS03100	COG2814	Major facilitator Superfamily
ES968_RS03105	COG0730	response to heat
ES968_RS03110	COG1802	Transcriptional regulator
ES968_RS03115	COG1388	LysM domain
ES968_RS03115	COG3858	chitin binding
ES968_RS03120	COG1819	glycosyl
ES968_RS03130	COG1785	Belongs to the alkaline phosphatase family
ES968_RS03135	COG5646	InterPro IPR014922
ES968_RS03145	COG0454	-acetyltransferase
ES968_RS03150	COG1078	dGTPase activity
ES968_RS03155	COG1388	LysM domain
ES968_RS03160	COG2814	Major facilitator Superfamily
ES968_RS03165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_RS03170	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES968_RS03180	COG2723	6-phospho-beta-galactosidase activity
ES968_RS03185	COG2188	Transcriptional regulator
ES968_RS03190	COG1940	carbohydrate kinase activity
ES968_RS03195	COG1482	cell wall glycoprotein biosynthetic process
ES968_RS03200	COG4124	Belongs to the glycosyl hydrolase 26 family
ES968_RS03245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES968_RS03250	COG0802	atpase or kinase
ES968_RS03255	COG1214	PFAM Peptidase M22, glycoprotease
ES968_RS03260	COG0456	acetyltransferase
ES968_RS03265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES968_RS03275	COG0488	(ABC) transporter
ES968_RS03280	COG0315	cyclic pyranopterin monophosphate synthase activity
ES968_RS03285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES968_RS03290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_RS03295	COG0805	protein transport
ES968_RS03310	COG1266	CAAX protease self-immunity
ES968_RS03320	COG0459	protein refolding
ES968_RS03335	COG0457	Tetratricopeptide repeat
ES968_RS03340	COG1063	alcohol dehydrogenase
ES968_RS03345	COG2211	Major facilitator Superfamily
ES968_RS03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_RS03355	COG1842	Phage shock protein A
ES968_RS03360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES968_RS03365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES968_RS03370	COG4260	virion core protein, lumpy skin disease virus
ES968_RS03380	COG2814	Major facilitator Superfamily
ES968_RS03385	COG1063	alcohol dehydrogenase
ES968_RS03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES968_RS03395	COG0823	Involved in the tonB-independent uptake of proteins
ES968_RS03415	COG2267	carboxylic ester hydrolase activity
ES968_RS03425	COG2132	Multicopper oxidase
ES968_RS03430	COG1113	amino acid transport
ES968_RS03440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_RS03445	COG0714	Associated with various cellular activities
ES968_RS03450	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES968_RS03455	COG1305	Transglutaminase-like
ES968_RS03460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES968_RS03460	COG0519	Catalyzes the synthesis of GMP from XMP
ES968_RS03475	COG2252	PERMEase
ES968_RS03480	COG3064	Membrane
ES968_RS03490	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES968_RS03500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES968_RS03505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES968_RS03510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES968_RS03515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES968_RS03520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES968_RS03525	COG0047	phosphoribosylformylglycinamidine synthase activity
ES968_RS03530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES968_RS03535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES968_RS03540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES968_RS03545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES968_RS03550	COG0138	bifunctional purine biosynthesis protein purh
ES968_RS03555	COG0151	Belongs to the GarS family
ES968_RS03560	COG1522	sequence-specific DNA binding
ES968_RS03565	COG0531	amino acid
ES968_RS03575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES968_RS03580	COG1470	cell adhesion involved in biofilm formation
ES968_RS03585	COG4496	protein, YerC YecD
ES968_RS03590	COG0069	glutamate synthase activity
ES968_RS03595	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES968_RS03600	COG0210	DNA helicase
ES968_RS03605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES968_RS03610	COG4851	CamS sex pheromone cAM373 precursor
ES968_RS03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_RS03625	COG1285	pathogenesis
ES968_RS03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_RS03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES968_RS03640	COG0154	amidase activity
ES968_RS03645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES968_RS03650	COG1309	transcriptional regulator
ES968_RS03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES968_RS03660	COG1597	lipid kinase activity
ES968_RS03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES968_RS03730	COG5444	nuclease activity
ES968_RS03740	COG3586	endonuclease activity
ES968_RS03750	COG0457	Tetratricopeptide repeat
ES968_RS03760	COG0217	transcriptional regulatory protein
ES968_RS03770	COG1309	transcriptional regulator
ES968_RS03775	COG3631	Ketosteroid isomerase-related protein
ES968_RS03780	COG0702	epimerase
ES968_RS03795	COG3546	catalase activity
ES968_RS03800	COG0454	-acetyltransferase
ES968_RS03810	COG5578	integral membrane protein
ES968_RS03815	COG2972	Histidine kinase
ES968_RS03825	COG1653	transport
ES968_RS03830	COG1175	transmembrane transport
ES968_RS03835	COG0395	ABC-type sugar transport system, permease component
ES968_RS03840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES968_RS03845	COG2207	Transcriptional regulator
ES968_RS03850	COG2755	lipolytic protein G-D-S-L family
ES968_RS03860	COG5578	integral membrane protein
ES968_RS03870	COG3401	FG-GAP repeat protein
ES968_RS03875	COG2755	lipolytic protein G-D-S-L family
ES968_RS03890	COG1653	transport
ES968_RS03895	COG4209	transmembrane transport
ES968_RS03900	COG0395	ABC-type sugar transport system, permease component
ES968_RS03905	COG1486	melibiose metabolic process
ES968_RS03910	COG2323	membrane
ES968_RS03915	COG2329	Antibiotic biosynthesis monooxygenase
ES968_RS03920	COG0346	lactoylglutathione lyase activity
ES968_RS03935	COG5583	Uncharacterized small protein (DUF2292)
ES968_RS03940	COG0670	Belongs to the BI1 family
ES968_RS03945	COG0697	spore germination
ES968_RS03950	COG1846	Transcriptional regulator
ES968_RS03955	COG1846	Transcriptional regulator
ES968_RS03975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_RS03975	COG2124	cytochrome p450
ES968_RS03980	COG1368	sulfuric ester hydrolase activity
ES968_RS03985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES968_RS03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_RS03995	COG1442	glycosyl transferase family 8
ES968_RS04000	COG1216	Glycosyl transferase, family 2
ES968_RS04005	COG1442	glycosyl transferase family 8
ES968_RS04010	COG2223	nitrite transmembrane transporter activity
ES968_RS04015	COG1011	Hydrolase
ES968_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS04030	COG0840	transmembrane signaling receptor activity
ES968_RS04035	COG0488	(ABC) transporter
ES968_RS04045	COG0789	Transcriptional regulator
ES968_RS04050	COG2814	Major facilitator Superfamily
ES968_RS04065	COG0488	(ABC) transporter
ES968_RS04070	COG0513	Belongs to the DEAD box helicase family
ES968_RS04075	COG0456	acetyltransferase
ES968_RS04080	COG2130	NADP-dependent
ES968_RS04085	COG1120	ATPase activity
ES968_RS04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS04100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES968_RS04115	COG3866	Pectate lyase
ES968_RS04120	COG0471	metal ion transport
ES968_RS04125	COG3290	protein histidine kinase activity
ES968_RS04130	COG4565	transcriptional regulatory protein
ES968_RS04135	COG3181	Tripartite tricarboxylate transporter family receptor
ES968_RS04140	COG2851	Citrate transporter
ES968_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS04150	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES968_RS04155	COG1254	Belongs to the acylphosphatase family
ES968_RS04160	COG2258	MOSC domain
ES968_RS04180	COG0024	Methionine aminopeptidase
ES968_RS04185	COG1263	PTS System
ES968_RS04185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS04190	COG1368	sulfuric ester hydrolase activity
ES968_RS04205	COG1115	amino acid carrier protein
ES968_RS04220	COG0697	spore germination
ES968_RS04230	COG0366	Alpha amylase catalytic
ES968_RS04235	COG2188	Transcriptional regulator
ES968_RS04240	COG0778	Nitroreductase
ES968_RS04245	COG0737	Belongs to the 5'-nucleotidase family
ES968_RS04250	COG0693	protein deglycase activity
ES968_RS04255	COG2814	Major facilitator Superfamily
ES968_RS04260	COG4840	Belongs to the UPF0435 family
ES968_RS04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES968_RS04270	COG4980	gas vesicle protein
ES968_RS04275	COG1295	ribonuclease BN
ES968_RS04280	COG0477	Major facilitator Superfamily
ES968_RS04285	COG0387	Pfam Sodium calcium exchanger
ES968_RS04295	COG0668	transmembrane transport
ES968_RS04300	COG0535	radical SAM domain protein
ES968_RS04310	COG0726	polysaccharide deacetylase
ES968_RS04315	COG2084	Dehydrogenase
ES968_RS04320	COG0598	Magnesium transport protein CorA
ES968_RS04325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES968_RS04330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES968_RS04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES968_RS04345	COG4637	Psort location Cytoplasmic, score
ES968_RS04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_RS04360	COG0022	dehydrogenase e1 component
ES968_RS04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_RS04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_RS04375	COG3284	Transcriptional regulator
ES968_RS04385	COG1742	UPF0060 membrane protein
ES968_RS04410	COG4842	Belongs to the WXG100 family
ES968_RS04415	COG1486	melibiose metabolic process
ES968_RS04420	COG1737	Transcriptional regulator
ES968_RS04425	COG1263	PTS System
ES968_RS04425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS04430	COG5434	Belongs to the glycosyl hydrolase 28 family
ES968_RS04435	COG1132	(ABC) transporter
ES968_RS04440	COG1132	(ABC) transporter
ES968_RS04445	COG2259	Doxx family
ES968_RS04450	COG2514	catechol 2,3-dioxygenase activity
ES968_RS04455	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS04455	COG4977	sequence-specific DNA binding
ES968_RS04460	COG2814	Major facilitator Superfamily
ES968_RS04465	COG1082	Xylose isomerase domain protein TIM barrel
ES968_RS04475	COG4585	Histidine kinase
ES968_RS04480	COG2197	response regulator
ES968_RS04485	COG1131	(ABC) transporter
ES968_RS04490	COG1511	domain protein
ES968_RS04490	COG0842	Transport permease protein
ES968_RS04495	COG0842	Transport permease protein
ES968_RS04500	COG1695	Transcriptional regulator
ES968_RS04505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES968_RS04510	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES968_RS04515	COG1309	transcriptional regulator
ES968_RS04520	COG2814	Major facilitator Superfamily
ES968_RS04525	COG2318	DinB family
ES968_RS04535	COG1846	Transcriptional regulator
ES968_RS04540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES968_RS04540	COG0392	lysyltransferase activity
ES968_RS04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS04560	COG0384	phenazine biosynthesis protein PhzF
ES968_RS04565	COG0778	Nitroreductase
ES968_RS04580	COG1090	epimerase
ES968_RS04585	COG2137	regulation of response to DNA damage stimulus
ES968_RS04595	COG2814	Major facilitator Superfamily
ES968_RS04615	COG3103	Sh3 type 3 domain protein
ES968_RS04620	COG5658	integral membrane protein
ES968_RS04625	COG0596	Alpha beta hydrolase
ES968_RS04630	COG0463	Glycosyl transferase, family 2
ES968_RS04635	COG4485	Bacterial membrane protein, YfhO
ES968_RS04640	COG1988	membrane-bound metal-dependent
ES968_RS04645	COG1194	a g-specific adenine glycosylase
ES968_RS04655	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS04670	COG3557	Belongs to the UPF0374 family
ES968_RS04675	COG1132	(ABC) transporter
ES968_RS04680	COG4129	membrane
ES968_RS04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES968_RS04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES968_RS04695	COG0735	belongs to the Fur family
ES968_RS04810	COG4326	sporulation control protein
ES968_RS04820	COG5577	PFAM Coat F domain
ES968_RS04825	COG3340	Belongs to the peptidase S51 family
ES968_RS04830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES968_RS04845	COG0753	catalase activity
ES968_RS04850	COG1116	anion transmembrane transporter activity
ES968_RS04855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES968_RS04860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES968_RS04865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_RS04875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES968_RS04885	COG1476	TRANSCRIPTIONal
ES968_RS04895	COG3382	B3 4 domain protein
ES968_RS04900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES968_RS04910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES968_RS04920	COG0789	Transcriptional regulator
ES968_RS04925	COG1664	Polymer-forming cytoskeletal
ES968_RS04930	COG1664	Polymer-forming cytoskeletal
ES968_RS04935	COG2766	serine protein kinase
ES968_RS04940	COG2718	Belongs to the UPF0229 family
ES968_RS04945	COG1846	Transcriptional regulator
ES968_RS04950	COG1566	PFAM secretion protein HlyD family protein
ES968_RS04955	COG2814	Major facilitator Superfamily
ES968_RS04960	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES968_RS04980	COG1725	Transcriptional regulator
ES968_RS04985	COG1131	(ABC) transporter
ES968_RS04990	COG1131	(ABC) transporter
ES968_RS04995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_RS05000	COG1278	Cold shock
ES968_RS05010	COG1464	Belongs to the NlpA lipoprotein family
ES968_RS05015	COG3706	GGDEF domain
ES968_RS05020	COG1823	symporter activity
ES968_RS05025	COG5444	nuclease activity
ES968_RS05050	COG0582	viral genome integration into host DNA
ES968_RS05055	COG2946	Replication initiation factor
ES968_RS05105	COG5644	endopeptidase inhibitor activity
ES968_RS05110	COG0791	NLP P60 protein
ES968_RS05110	COG0741	lytic transglycosylase activity
ES968_RS05140	COG0457	Tetratricopeptide repeat
ES968_RS05160	COG5577	PFAM Coat F domain
ES968_RS05165	COG0737	Belongs to the 5'-nucleotidase family
ES968_RS05165	COG1525	nuclease
ES968_RS05165	COG4085	toxin activity
ES968_RS05170	COG3764	Sortase (surface protein transpeptidase)
ES968_RS05175	COG0564	pseudouridine synthase activity
ES968_RS05185	COG0517	IMP dehydrogenase activity
ES968_RS05190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES968_RS05195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES968_RS05195	COG3153	acetyltransferase
ES968_RS05200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_RS05205	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES968_RS05210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES968_RS05215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES968_RS05220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES968_RS05225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES968_RS05230	COG4585	Histidine kinase
ES968_RS05230	COG2203	Gaf domain
ES968_RS05235	COG2197	response regulator
ES968_RS05240	COG0431	NADPH-dependent FMN reductase
ES968_RS05255	COG1388	LysM domain
ES968_RS05255	COG0791	NLP P60 protein
ES968_RS05260	COG1959	2 iron, 2 sulfur cluster binding
ES968_RS05265	COG0668	transmembrane transport
ES968_RS05270	COG2719	SpoVR family
ES968_RS05275	COG1785	Belongs to the alkaline phosphatase family
ES968_RS05280	COG0791	NLP P60 protein
ES968_RS05280	COG1388	LysM domain
ES968_RS05285	COG0583	DNA-binding transcription factor activity
ES968_RS05290	COG0372	Belongs to the citrate synthase family
ES968_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS05300	COG0531	amino acid
ES968_RS05305	COG0733	neurotransmitter:sodium symporter activity
ES968_RS05310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS05315	COG0456	acetyltransferase
ES968_RS05330	COG1595	DNA-templated transcription, initiation
ES968_RS05335	COG0667	Aldo Keto reductase
ES968_RS05340	COG0204	Acyl-transferase
ES968_RS05345	COG1253	flavin adenine dinucleotide binding
ES968_RS05350	COG0789	Transcriptional regulator
ES968_RS05360	COG1253	flavin adenine dinucleotide binding
ES968_RS05365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES968_RS05370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES968_RS05375	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_RS05385	COG0668	transmembrane transport
ES968_RS05390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES968_RS05395	COG0726	polysaccharide deacetylase
ES968_RS05400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_RS05405	COG1757	Na H antiporter
ES968_RS05410	COG0589	response to stress
ES968_RS05420	COG1132	(ABC) transporter
ES968_RS05425	COG1132	(ABC) transporter
ES968_RS05430	COG0702	epimerase
ES968_RS05450	COG0189	ligase activity
ES968_RS05455	COG0189	ligase activity
ES968_RS05460	COG4399	Belongs to the UPF0754 family
ES968_RS05465	COG3679	Belongs to the UPF0342 family
ES968_RS05470	COG4335	DNA alkylation repair
ES968_RS05475	COG0561	phosphatase activity
ES968_RS05480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES968_RS05485	COG0475	glutathione-regulated potassium exporter activity
ES968_RS05490	COG0490	domain, Protein
ES968_RS05500	COG1024	Enoyl-CoA hydratase
ES968_RS05510	COG4152	abc transporter atp-binding protein
ES968_RS05515	COG1668	transmembrane transport
ES968_RS05520	COG0420	3'-5' exonuclease activity
ES968_RS05525	COG4717	serine-type aminopeptidase activity
ES968_RS05530	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES968_RS05540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES968_RS05570	COG1846	Transcriptional regulator
ES968_RS05575	COG4980	gas vesicle protein
ES968_RS05590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES968_RS05595	COG0537	adenosine 5'-monophosphoramidase activity
ES968_RS05600	COG1131	(ABC) transporter
ES968_RS05605	COG4473	ABC transporter
ES968_RS05615	COG1473	amidohydrolase
ES968_RS05620	COG3069	C4-dicarboxylate transmembrane transporter activity
ES968_RS05630	COG2329	Antibiotic biosynthesis monooxygenase
ES968_RS05635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_RS05640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES968_RS05645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ES968_RS05650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ES968_RS05655	COG1309	transcriptional regulator
ES968_RS05660	COG1511	domain protein
ES968_RS05665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_RS05670	COG4377	Putative membrane peptidase family (DUF2324)
ES968_RS05680	COG1363	Peptidase, m42
ES968_RS05685	COG4405	Protein conserved in bacteria
ES968_RS05690	COG1301	dicarboxylic acid transport
ES968_RS05700	COG1234	tRNA 3'-trailer cleavage
ES968_RS05705	COG0095	Lipoate-protein ligase
ES968_RS05710	COG0702	epimerase
ES968_RS05715	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS05725	COG0501	Belongs to the peptidase M48B family
ES968_RS05735	COG0456	acetyltransferase
ES968_RS05740	COG0604	alcohol dehydrogenase
ES968_RS05745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES968_RS05750	COG0406	alpha-ribazole phosphatase activity
ES968_RS05755	COG0183	Belongs to the thiolase family
ES968_RS05760	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS05765	COG1268	BioY protein
ES968_RS05770	COG0840	transmembrane signaling receptor activity
ES968_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS05790	COG4903	ComK protein
ES968_RS05795	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS05805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_RS05820	COG0398	Pfam SNARE associated Golgi protein
ES968_RS05825	COG0681	Belongs to the peptidase S26 family
ES968_RS05830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES968_RS05835	COG1846	Transcriptional regulator
ES968_RS05845	COG0738	Major facilitator superfamily
ES968_RS05850	COG0673	inositol 2-dehydrogenase activity
ES968_RS05855	COG0561	phosphatase activity
ES968_RS05860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_RS05865	COG1609	Transcriptional regulator
ES968_RS05870	COG3180	Ammonia monooxygenase
ES968_RS05875	COG2814	Major facilitator Superfamily
ES968_RS05875	COG0477	Major facilitator Superfamily
ES968_RS05880	COG4533	DNA binding
ES968_RS05890	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES968_RS05895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES968_RS05900	COG1074	ATP-dependent DNA helicase activity
ES968_RS05905	COG0420	3'-5' exonuclease activity
ES968_RS05910	COG0419	ATPase involved in DNA repair
ES968_RS05915	COG1403	HNH endonuclease
ES968_RS05955	COG5337	Spore coat protein CotH
ES968_RS05960	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES968_RS05970	COG1404	Belongs to the peptidase S8 family
ES968_RS05980	COG0367	asparagine synthase
ES968_RS05985	COG1562	ergosterol biosynthetic process
ES968_RS05990	COG0534	Mate efflux family protein
ES968_RS05995	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS05995	COG2207	Transcriptional regulator
ES968_RS06000	COG1609	Transcriptional regulator
ES968_RS06005	COG0673	inositol 2-dehydrogenase activity
ES968_RS06010	COG2318	DinB family
ES968_RS06015	COG1279	arginine transmembrane transporter activity
ES968_RS06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_RS06025	COG1357	PFAM Pentapeptide repeats (8 copies)
ES968_RS06030	COG2267	carboxylic ester hydrolase activity
ES968_RS06040	COG2153	protein acetylation
ES968_RS06045	COG0646	methionine synthase
ES968_RS06045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES968_RS06050	COG1666	GTP binding
ES968_RS06055	COG2996	Protein conserved in bacteria
ES968_RS06065	COG1307	EDD domain protein, DegV family
ES968_RS06070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS06085	COG0561	phosphatase activity
ES968_RS06090	COG1073	alpha beta
ES968_RS06095	COG2151	metal-sulfur cluster biosynthetic enzyme
ES968_RS06105	COG0277	FAD linked oxidase domain protein
ES968_RS06110	COG2271	Major facilitator Superfamily
ES968_RS06115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES968_RS06120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ES968_RS06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES968_RS06135	COG0505	Belongs to the CarA family
ES968_RS06140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES968_RS06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES968_RS06165	COG2267	carboxylic ester hydrolase activity
ES968_RS06175	COG1744	ABC transporter substrate-binding protein PnrA-like
ES968_RS06190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_RS06195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES968_RS06200	COG5504	Zn-dependent protease
ES968_RS06205	COG0444	Belongs to the ABC transporter superfamily
ES968_RS06210	COG4608	Belongs to the ABC transporter superfamily
ES968_RS06220	COG0601	transmembrane transport
ES968_RS06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_RS06235	COG0180	Tryptophanyl-tRNA synthetase
ES968_RS06240	COG4166	transmembrane transport
ES968_RS06245	COG0601	transmembrane transport
ES968_RS06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_RS06255	COG0444	Belongs to the ABC transporter superfamily
ES968_RS06260	COG4608	Belongs to the ABC transporter superfamily
ES968_RS06265	COG2814	Major facilitator Superfamily
ES968_RS06270	COG0456	acetyltransferase
ES968_RS06275	COG1393	Belongs to the ArsC family
ES968_RS06280	COG0861	Integral membrane protein TerC family
ES968_RS06290	COG4862	establishment of competence for transformation
ES968_RS06300	COG4469	Competence protein
ES968_RS06305	COG1164	Oligoendopeptidase f
ES968_RS06320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES968_RS06325	COG2346	COG2346, Truncated hemoglobins
ES968_RS06330	COG0741	lytic transglycosylase activity
ES968_RS06335	COG4116	CYTH
ES968_RS06345	COG2357	RelA SpoT domain protein
ES968_RS06350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES968_RS06355	COG0564	pseudouridine synthase activity
ES968_RS06360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES968_RS06365	COG0569	domain protein
ES968_RS06365	COG0475	glutathione-regulated potassium exporter activity
ES968_RS06370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES968_RS06375	COG0352	thiamine-phosphate diphosphorylase activity
ES968_RS06380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES968_RS06385	COG2104	thiamine diphosphate biosynthetic process
ES968_RS06390	COG2022	thiamine diphosphate biosynthetic process
ES968_RS06395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_RS06400	COG0351	phosphomethylpyrimidine kinase
ES968_RS06405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES968_RS06460	COG0210	DNA helicase
ES968_RS06470	COG2153	protein acetylation
ES968_RS06475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES968_RS06480	COG2382	esterase
ES968_RS06485	COG0626	cystathionine gamma-synthase activity
ES968_RS06490	COG0626	cystathionine gamma-synthase activity
ES968_RS06495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS06500	COG5505	Protein of unknown function (DUF819)
ES968_RS06545	COG1396	sequence-specific DNA binding
ES968_RS06605	COG0457	Tetratricopeptide repeat
ES968_RS06610	COG5444	nuclease activity
ES968_RS06625	COG3328	transposase activity
ES968_RS06630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS06640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES968_RS06660	COG0109	protoheme IX farnesyltransferase activity
ES968_RS06670	COG0726	polysaccharide deacetylase
ES968_RS06685	COG5504	Zn-dependent protease
ES968_RS06690	COG2205	protein histidine kinase activity
ES968_RS06705	COG2427	Protein of unknown function (DUF1641)
ES968_RS06715	COG1051	belongs to the nudix hydrolase family
ES968_RS06725	COG2124	cytochrome p450
ES968_RS06730	COG1819	glycosyl
ES968_RS06740	COG1587	Uroporphyrinogen-III synthase
ES968_RS06745	COG0390	transport system, permease component
ES968_RS06750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_RS06755	COG0697	spore germination
ES968_RS06760	COG4297	protein containing double-stranded beta helix domain
ES968_RS06770	COG1252	NADH dehydrogenase
ES968_RS06775	COG1904	glucuronate isomerase
ES968_RS06780	COG2211	Major facilitator Superfamily
ES968_RS06785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES968_RS06790	COG1063	alcohol dehydrogenase
ES968_RS06795	COG1312	Catalyzes the dehydration of D-mannonate
ES968_RS06800	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS06805	COG2271	Major facilitator Superfamily
ES968_RS06810	COG1609	Transcriptional regulator
ES968_RS06815	COG0246	Mannitol dehydrogenase
ES968_RS06820	COG2721	sulfolactate sulfo-lyase activity
ES968_RS06825	COG0730	response to heat
ES968_RS06830	COG2318	DinB family
ES968_RS06850	COG0457	Tetratricopeptide repeat
ES968_RS06865	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS06865	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_RS06865	COG1388	LysM domain
ES968_RS06875	COG4195	phage-related replication protein
ES968_RS06880	COG3546	catalase activity
ES968_RS06885	COG2856	Zn peptidase
ES968_RS06890	COG1396	sequence-specific DNA binding
ES968_RS06900	COG1522	sequence-specific DNA binding
ES968_RS06905	COG1484	DNA-dependent DNA replication
ES968_RS06925	COG1595	DNA-templated transcription, initiation
ES968_RS06930	COG5484	DNA packaging
ES968_RS06930	COG3728	DNA packaging
ES968_RS06935	COG1783	phage Terminase large subunit
ES968_RS06940	COG5518	Phage portal protein
ES968_RS06945	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES968_RS06950	COG4653	Phage capsid family
ES968_RS07000	COG3953	SLT domain
ES968_RS07000	COG5412	phage tail tape measure protein
ES968_RS07000	COG3953	SLT domain
ES968_RS07000	COG5412	phage tail tape measure protein
ES968_RS07000	COG3953	SLT domain
ES968_RS07000	COG5412	phage tail tape measure protein
ES968_RS07005	COG1652	LysM domain
ES968_RS07010	COG4193	domain, Protein
ES968_RS07020	COG3628	GPW Gp25 family protein
ES968_RS07025	COG3299	homolog of phage Mu protein gp47
ES968_RS07030	COG3778	Protein conserved in bacteria
ES968_RS07070	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS07070	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_RS07090	COG0306	phosphate transporter
ES968_RS07095	COG1392	Phosphate transport regulator
ES968_RS07100	COG0531	amino acid
ES968_RS07105	COG0346	lactoylglutathione lyase activity
ES968_RS07110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES968_RS07115	COG0463	Glycosyl transferase, family 2
ES968_RS07120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_RS07125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_RS07130	COG2362	D-Aminopeptidase
ES968_RS07135	COG0601	transmembrane transport
ES968_RS07140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_RS07145	COG0444	Belongs to the ABC transporter superfamily
ES968_RS07150	COG4166	transmembrane transport
ES968_RS07155	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES968_RS07160	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_RS07165	COG0791	NLP P60 protein
ES968_RS07170	COG4608	Belongs to the ABC transporter superfamily
ES968_RS07175	COG2706	6-phosphogluconolactonase activity
ES968_RS07180	COG1834	amidinotransferase
ES968_RS07185	COG1607	acyl-coa hydrolase
ES968_RS07190	COG1017	nitric oxide dioxygenase activity
ES968_RS07190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES968_RS07200	COG2323	membrane
ES968_RS07205	COG2318	DinB family
ES968_RS07210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS07215	COG2076	Multidrug Resistance protein
ES968_RS07220	COG2076	Multidrug Resistance protein
ES968_RS07225	COG0788	formyltetrahydrofolate deformylase activity
ES968_RS07230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES968_RS07235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES968_RS07240	COG1764	response to oxidative stress
ES968_RS07245	COG1846	Transcriptional regulator
ES968_RS07250	COG1764	response to oxidative stress
ES968_RS07260	COG0590	tRNA wobble adenosine to inosine editing
ES968_RS07265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_RS07270	COG1404	Belongs to the peptidase S8 family
ES968_RS07275	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS07280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES968_RS07285	COG1122	ATPase activity
ES968_RS07290	COG4721	ABC-type cobalt transport system, permease component
ES968_RS07300	COG0745	RESPONSE REGULATOR receiver
ES968_RS07305	COG5002	protein histidine kinase activity
ES968_RS07305	COG3850	Histidine kinase
ES968_RS07315	COG3212	peptidase
ES968_RS07330	COG2239	Acts as a magnesium transporter
ES968_RS07335	COG0789	Transcriptional regulator
ES968_RS07350	COG1846	Transcriptional regulator
ES968_RS07355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_RS07360	COG0726	polysaccharide deacetylase
ES968_RS07365	COG1408	metallophosphoesterase
ES968_RS07375	COG0463	Glycosyl transferase, family 2
ES968_RS07380	COG3285	dna ligase
ES968_RS07380	COG1793	dna ligase
ES968_RS07385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES968_RS07390	COG5001	Diguanylate cyclase
ES968_RS07390	COG3300	MHYT domain
ES968_RS07395	COG0586	Pfam SNARE associated Golgi protein
ES968_RS07400	COG0861	Integral membrane protein TerC family
ES968_RS07405	COG1191	sigma factor activity
ES968_RS07425	COG0501	Belongs to the peptidase M48B family
ES968_RS07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES968_RS07445	COG3594	Acyltransferase
ES968_RS07450	COG5002	protein histidine kinase activity
ES968_RS07455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES968_RS07465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES968_RS07470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES968_RS07475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES968_RS07480	COG0436	Aminotransferase
ES968_RS07485	COG1850	ribulose-bisphosphate carboxylase activity
ES968_RS07490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES968_RS07495	COG0235	Class ii aldolase
ES968_RS07500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES968_RS07505	COG3339	Conserved Protein
ES968_RS07520	COG3852	Histidine kinase
ES968_RS07530	COG1846	Transcriptional regulator
ES968_RS07535	COG1360	Flagellar Motor Protein
ES968_RS07540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES968_RS07550	COG0542	response to heat
ES968_RS07555	COG3949	Membrane
ES968_RS07560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES968_RS07565	COG0720	synthase
ES968_RS07570	COG0602	queuosine metabolic process
ES968_RS07575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES968_RS07580	COG1733	regulation of RNA biosynthetic process
ES968_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS07660	COG4873	Protein conserved in bacteria
ES968_RS07670	COG3773	Cell wall hydrolase
ES968_RS07675	COG2244	polysaccharide biosynthetic process
ES968_RS07680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS07685	COG2217	Heavy metal translocating P-type atpase
ES968_RS07695	COG0006	proline dipeptidase activity
ES968_RS07700	COG1609	Transcriptional regulator
ES968_RS07705	COG3711	transcriptional antiterminator
ES968_RS07710	COG1263	PTS System
ES968_RS07710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS07710	COG2190	(PTS) system
ES968_RS07715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS07720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES968_RS07730	COG1533	DNA photolyase activity
ES968_RS07735	COG0456	acetyltransferase
ES968_RS07740	COG0840	transmembrane signaling receptor activity
ES968_RS07745	COG2084	Dehydrogenase
ES968_RS07750	COG3328	transposase activity
ES968_RS07755	COG2340	Cysteine-rich secretory protein family
ES968_RS07760	COG0768	penicillin binding
ES968_RS07765	COG4191	Histidine kinase
ES968_RS07770	COG0436	Aminotransferase
ES968_RS07780	COG0835	chemotaxis
ES968_RS07780	COG0784	Response regulator, receiver
ES968_RS07790	COG2814	Major facilitator Superfamily
ES968_RS07795	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_RS07800	COG1408	metallophosphoesterase
ES968_RS07805	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS07810	COG2200	EAL domain
ES968_RS07815	COG4703	Protein of unknown function (DUF1797)
ES968_RS07820	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES968_RS07830	COG0517	IMP dehydrogenase activity
ES968_RS07835	COG0583	DNA-binding transcription factor activity
ES968_RS07840	COG0716	FMN binding
ES968_RS07850	COG0716	FMN binding
ES968_RS07855	COG2171	N-acyltransferase activity
ES968_RS07860	COG1473	amidohydrolase
ES968_RS07870	COG0668	transmembrane transport
ES968_RS07875	COG0450	alkyl hydroperoxide reductase
ES968_RS07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS07900	COG0746	molybdenum cofactor guanylyltransferase activity
ES968_RS07905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_RS07910	COG0303	'Molybdopterin
ES968_RS07915	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES968_RS07920	COG0314	molybdopterin synthase activity
ES968_RS07925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES968_RS07930	COG1132	(ABC) transporter
ES968_RS07935	COG1132	(ABC) transporter
ES968_RS07945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES968_RS07950	COG1136	(ABC) transporter
ES968_RS07955	COG0577	efflux transmembrane transporter activity
ES968_RS07960	COG1349	DNA-binding transcription factor activity
ES968_RS07965	COG1105	Belongs to the carbohydrate kinase PfkB family
ES968_RS07970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES968_RS07970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES968_RS07970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS07975	COG0681	Belongs to the peptidase S26 family
ES968_RS07985	COG0488	(ABC) transporter
ES968_RS07990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES968_RS07995	COG2309	aminopeptidase activity
ES968_RS08005	COG1077	Cell shape determining protein MreB Mrl
ES968_RS08010	COG2002	toxin-antitoxin pair type II binding
ES968_RS08015	COG3852	Histidine kinase
ES968_RS08025	COG0569	domain protein
ES968_RS08030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES968_RS08035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES968_RS08040	COG5503	Protein of unknown function (DUF1447)
ES968_RS08045	COG0561	phosphatase activity
ES968_RS08050	COG0242	peptide deformylase activity
ES968_RS08060	COG0497	DNA recombination
ES968_RS08065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_RS08070	COG0022	dehydrogenase e1 component
ES968_RS08075	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_RS08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_RS08085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS08095	COG1982	Orn Lys Arg decarboxylase major
ES968_RS08100	COG4476	Belongs to the UPF0223 family
ES968_RS08105	COG4493	Belongs to the UPF0637 family
ES968_RS08115	COG0483	inositol monophosphate 1-phosphatase activity
ES968_RS08125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES968_RS08165	COG1217	gtp-binding protein TYPA
ES968_RS08175	COG4896	Protein conserved in bacteria
ES968_RS08185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES968_RS08190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES968_RS08195	COG2066	Belongs to the glutaminase family
ES968_RS08200	COG4838	Belongs to the UPF0358 family
ES968_RS08205	COG0772	Belongs to the SEDS family
ES968_RS08210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES968_RS08215	COG1612	heme a metabolic process
ES968_RS08220	COG0109	protoheme IX farnesyltransferase activity
ES968_RS08225	COG2010	Cytochrome c
ES968_RS08225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES968_RS08230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES968_RS08235	COG1845	cytochrome c oxidase, subunit III
ES968_RS08240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES968_RS08245	COG3336	cytochrome c oxidase
ES968_RS08255	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES968_RS08260	COG2340	Cysteine-rich secretory protein family
ES968_RS08275	COG3679	Belongs to the UPF0342 family
ES968_RS08280	COG4471	UPF0298 protein
ES968_RS08285	COG0742	ribosomal rna small subunit methyltransferase
ES968_RS08290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES968_RS08295	COG3314	Sporulation integral membrane protein YlbJ
ES968_RS08300	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES968_RS08305	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES968_RS08310	COG1323	Belongs to the UPF0348 family
ES968_RS08320	COG1399	metal-binding, possibly nucleic acid-binding protein
ES968_RS08335	COG0454	-acetyltransferase
ES968_RS08340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES968_RS08345	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES968_RS08350	COG2001	Belongs to the MraZ family
ES968_RS08355	COG0275	rRNA processing
ES968_RS08360	COG4839	cell division protein FtsL
ES968_RS08365	COG0768	penicillin binding
ES968_RS08370	COG0768	penicillin binding
ES968_RS08375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES968_RS08380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES968_RS08385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES968_RS08390	COG0772	Belongs to the SEDS family
ES968_RS08395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_RS08400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES968_RS08405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES968_RS08410	COG3879	Bacterial protein of unknown function (DUF881)
ES968_RS08415	COG3879	Bacterial protein of unknown function (DUF881)
ES968_RS08420	COG3856	small basic protein
ES968_RS08425	COG0849	cell division
ES968_RS08430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES968_RS08435	COG1404	Belongs to the peptidase S8 family
ES968_RS08435	COG4412	M6 family metalloprotease domain protein
ES968_RS08445	COG1191	sigma factor activity
ES968_RS08450	COG1191	sigma factor activity
ES968_RS08455	COG1119	ATPase activity
ES968_RS08460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_RS08465	COG1873	PFAM PRC-barrel domain
ES968_RS08470	COG1496	oxidoreductase activity
ES968_RS08475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES968_RS08480	COG1799	cell septum assembly
ES968_RS08485	COG0762	integral membrane protein
ES968_RS08490	COG2302	S4 RNA-binding domain
ES968_RS08495	COG3599	regulation of cell shape
ES968_RS08500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES968_RS08510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_RS08515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES968_RS08520	COG0564	pseudouridine synthase activity
ES968_RS08525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES968_RS08530	COG2233	PERMEase
ES968_RS08535	COG0540	Belongs to the ATCase OTCase family
ES968_RS08540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES968_RS08545	COG0505	Belongs to the CarA family
ES968_RS08550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES968_RS08555	COG0543	2 iron, 2 sulfur cluster binding
ES968_RS08560	COG0167	dihydroorotate dehydrogenase activity
ES968_RS08565	COG0284	orotidine-5'-phosphate decarboxylase activity
ES968_RS08570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES968_RS08575	COG0175	sulfate reduction
ES968_RS08580	COG0306	phosphate transporter
ES968_RS08585	COG2046	Belongs to the sulfate adenylyltransferase family
ES968_RS08590	COG0529	Catalyzes the synthesis of activated sulfate
ES968_RS08595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES968_RS08600	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES968_RS08605	COG1648	precorrin-2 dehydrogenase activity
ES968_RS08615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES968_RS08620	COG1561	YicC-like family, N-terminal region
ES968_RS08630	COG0194	GDP metabolic process
ES968_RS08635	COG1758	RNA polymerase activity
ES968_RS08640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES968_RS08645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES968_RS08650	COG0242	peptide deformylase activity
ES968_RS08655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES968_RS08660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES968_RS08660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES968_RS08665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES968_RS08670	COG0631	protein serine/threonine phosphatase activity
ES968_RS08675	COG0515	serine threonine protein kinase
ES968_RS08675	COG2815	serine threonine protein kinase
ES968_RS08680	COG1162	GTPase activity
ES968_RS08685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES968_RS08690	COG1564	THIamine pyrophosphokinase
ES968_RS08700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES968_RS08705	COG1302	Protein conserved in bacteria
ES968_RS08710	COG1461	Dihydroxyacetone kinase
ES968_RS08715	COG1760	l-serine dehydratase
ES968_RS08720	COG1760	l-serine dehydratase
ES968_RS08725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES968_RS08730	COG2050	protein possibly involved in aromatic compounds catabolism
ES968_RS08730	COG1349	DNA-binding transcription factor activity
ES968_RS08735	COG0416	fatty acid biosynthetic process
ES968_RS08740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES968_RS08745	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS08755	COG0571	ribonuclease III activity
ES968_RS08760	COG1196	nuclear chromosome segregation
ES968_RS08765	COG0552	protein localization to endoplasmic reticulum
ES968_RS08775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES968_RS08780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES968_RS08785	COG0228	four-way junction DNA binding
ES968_RS08790	COG1837	Belongs to the UPF0109 family
ES968_RS08800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES968_RS08805	COG0336	Belongs to the RNA methyltransferase TrmD family
ES968_RS08810	COG0335	large ribosomal subunit rRNA binding
ES968_RS08815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES968_RS08820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES968_RS08830	COG2257	FlhB HrpN YscU SpaS Family
ES968_RS08835	COG0045	succinate-CoA ligase (ADP-forming) activity
ES968_RS08840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES968_RS08845	COG0758	DNA mediated transformation
ES968_RS08850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES968_RS08855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES968_RS08860	COG4974	Belongs to the 'phage' integrase family
ES968_RS08865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES968_RS08870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES968_RS08875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES968_RS08880	COG1815	bacterial-type flagellum-dependent cell motility
ES968_RS08885	COG1558	bacterial-type flagellum-dependent cell motility
ES968_RS08890	COG1677	Flagellar hook-basal body complex protein FliE
ES968_RS08895	COG1766	The M ring may be actively involved in energy transduction
ES968_RS08900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_RS08905	COG1317	bacterial-type flagellum organization
ES968_RS08910	COG1157	protein secretion by the type III secretion system
ES968_RS08915	COG2882	bacterial-type flagellum organization
ES968_RS08920	COG3334	PFAM MgtE intracellular
ES968_RS08925	COG3144	bacterial-type flagellum assembly
ES968_RS08930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES968_RS08935	COG4786	Flagellar basal body rod
ES968_RS08940	COG1582	Flagellar protein (FlbD)
ES968_RS08945	COG1580	Controls the rotational direction of flagella during chemotaxis
ES968_RS08950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_RS08955	COG1776	CheC inhibitor of MCP methylation
ES968_RS08955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_RS08960	COG2201	protein-glutamate methylesterase activity
ES968_RS08965	COG3190	flagellar
ES968_RS08970	COG1338	Plays a role in the flagellum-specific transport system
ES968_RS08975	COG1987	bacterial-type flagellum assembly
ES968_RS08980	COG1684	flagellar biosynthetic protein fliR
ES968_RS08985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES968_RS08990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES968_RS08995	COG1419	protein localization to endoplasmic reticulum
ES968_RS09000	COG0455	bacterial-type flagellum organization
ES968_RS09005	COG2201	protein-glutamate methylesterase activity
ES968_RS09010	COG2198	Histidine kinase
ES968_RS09010	COG0643	Histidine kinase
ES968_RS09015	COG0835	chemotaxis
ES968_RS09020	COG1776	CheC inhibitor of MCP methylation
ES968_RS09025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES968_RS09030	COG1191	sigma factor activity
ES968_RS09040	COG0052	Belongs to the universal ribosomal protein uS2 family
ES968_RS09045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES968_RS09050	COG0528	UMP kinase activity
ES968_RS09055	COG0233	cytoplasmic translational termination
ES968_RS09060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES968_RS09065	COG4589	Belongs to the CDS family
ES968_RS09070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES968_RS09075	COG0750	zinc metalloprotease
ES968_RS09080	COG0442	prolyl-tRNA aminoacylation
ES968_RS09085	COG2176	DNA-directed DNA polymerase activity
ES968_RS09090	COG0779	Required for maturation of 30S ribosomal subunits
ES968_RS09095	COG0195	Participates in both transcription termination and antitermination
ES968_RS09100	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES968_RS09105	COG1358	cellular component organization or biogenesis
ES968_RS09110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES968_RS09115	COG1550	Protein conserved in bacteria
ES968_RS09120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES968_RS09125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES968_RS09130	COG0196	riboflavin kinase activity
ES968_RS09135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES968_RS09140	COG1185	polyribonucleotide nucleotidyltransferase activity
ES968_RS09145	COG0726	polysaccharide deacetylase
ES968_RS09150	COG0612	Peptidase, M16
ES968_RS09155	COG1873	PFAM PRC-barrel domain
ES968_RS09160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES968_RS09165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES968_RS09170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES968_RS09175	COG0527	aspartate kinase activity
ES968_RS09180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES968_RS09185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES968_RS09190	COG0740	serine-type endopeptidase activity
ES968_RS09200	COG4980	gas vesicle protein
ES968_RS09200	COG1674	ftsk spoiiie
ES968_RS09205	COG2188	Transcriptional regulator
ES968_RS09210	COG2814	Major facilitator Superfamily
ES968_RS09215	COG0612	Peptidase, M16
ES968_RS09220	COG0612	Peptidase, M16
ES968_RS09225	COG0300	oxidoreductase activity
ES968_RS09240	COG1426	Protein conserved in bacteria
ES968_RS09245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES968_RS09250	COG1058	Belongs to the CinA family
ES968_RS09250	COG1546	Belongs to the CinA family
ES968_RS09255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES968_RS09260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES968_RS09265	COG1418	mRNA catabolic process
ES968_RS09270	COG1692	metallophosphoesterase
ES968_RS09275	COG2359	stage V sporulation protein S
ES968_RS09280	COG1063	alcohol dehydrogenase
ES968_RS09285	COG0156	8-amino-7-oxononanoate synthase activity
ES968_RS09290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES968_RS09295	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES968_RS09305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES968_RS09310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES968_RS09380	COG3328	transposase activity
ES968_RS09400	COG3226	Transcriptional regulator
ES968_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS09415	COG1404	Belongs to the peptidase S8 family
ES968_RS09425	COG4195	phage-related replication protein
ES968_RS09430	COG1764	response to oxidative stress
ES968_RS09435	COG2076	Multidrug Resistance protein
ES968_RS09440	COG2076	Multidrug Resistance protein
ES968_RS09455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES968_RS09460	COG1923	regulation of RNA biosynthetic process
ES968_RS09475	COG1780	Probably involved in ribonucleotide reductase function
ES968_RS09480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES968_RS09485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES968_RS09490	COG4112	unkown
ES968_RS09495	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS09505	COG0464	growth
ES968_RS09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES968_RS09515	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES968_RS09520	COG0789	Transcriptional regulator
ES968_RS09525	COG0174	glutamine synthetase
ES968_RS09535	COG3328	transposase activity
ES968_RS09550	COG5444	nuclease activity
ES968_RS09590	COG4282	regulation of fungal-type cell wall biogenesis
ES968_RS09605	COG3328	transposase activity
ES968_RS09615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS09630	COG3655	Transcriptional regulator
ES968_RS09655	COG0135	phosphoribosylanthranilate isomerase activity
ES968_RS09660	COG2211	Major facilitator Superfamily
ES968_RS09665	COG3507	Belongs to the glycosyl hydrolase 43 family
ES968_RS09670	COG1940	carbohydrate kinase activity
ES968_RS09675	COG2115	Belongs to the xylose isomerase family
ES968_RS09680	COG1070	Carbohydrate kinase
ES968_RS09690	COG1525	nuclease
ES968_RS09695	COG2814	Major facilitator Superfamily
ES968_RS09700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES968_RS09715	COG0756	dUTP diphosphatase activity
ES968_RS09755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_RS09765	COG3832	glyoxalase III activity
ES968_RS09810	COG4195	phage-related replication protein
ES968_RS09820	COG0346	lactoylglutathione lyase activity
ES968_RS09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES968_RS09835	COG1388	LysM domain
ES968_RS09840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES968_RS09845	COG4224	UPF0291 protein
ES968_RS09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES968_RS09860	COG3763	UPF0154 protein
ES968_RS09870	COG0785	Cytochrome C biogenesis protein
ES968_RS09875	COG2201	protein-glutamate methylesterase activity
ES968_RS09880	COG4846	Membrane protein involved in cytochrome C biogenesis
ES968_RS09890	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_RS09905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES968_RS09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS09930	COG0824	Thioesterase
ES968_RS09940	COG4841	protein insertion into membrane
ES968_RS09945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES968_RS09950	COG1832	CoA-binding protein
ES968_RS09955	COG0187	DNA topoisomerase II activity
ES968_RS09960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES968_RS09970	COG1115	amino acid carrier protein
ES968_RS09975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES968_RS09985	COG5520	Belongs to the glycosyl hydrolase 30 family
ES968_RS09995	COG2246	polysaccharide biosynthetic process
ES968_RS10000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_RS10005	COG0586	Pfam SNARE associated Golgi protein
ES968_RS10010	COG2404	hydrolase activity, acting on ester bonds
ES968_RS10015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES968_RS10020	COG1024	Enoyl-CoA hydratase
ES968_RS10025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES968_RS10030	COG0511	ligase activity, forming carbon-carbon bonds
ES968_RS10035	COG0439	Biotin carboxylase
ES968_RS10040	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS10045	COG1960	acyl-CoA dehydrogenase activity
ES968_RS10055	COG1649	PFAM Uncharacterised BCR, COG1649
ES968_RS10065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS10065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES968_RS10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS10075	COG2027	D-alanyl-D-alanine carboxypeptidase
ES968_RS10080	COG2017	converts alpha-aldose to the beta-anomer
ES968_RS10085	COG0534	Mate efflux family protein
ES968_RS10100	COG0582	viral genome integration into host DNA
ES968_RS10105	COG0166	Belongs to the GPI family
ES968_RS10110	COG0405	Gamma-glutamyltransferase
ES968_RS10115	COG0583	DNA-binding transcription factor activity
ES968_RS10120	COG0604	alcohol dehydrogenase
ES968_RS10125	COG0493	'glutamate synthase
ES968_RS10130	COG0069	glutamate synthase activity
ES968_RS10130	COG0067	glutamate synthase
ES968_RS10130	COG0070	glutamate synthase
ES968_RS10135	COG0583	DNA-binding transcription factor activity
ES968_RS10140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES968_RS10145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_RS10155	COG0300	oxidoreductase activity
ES968_RS10160	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES968_RS10170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS10185	COG1131	(ABC) transporter
ES968_RS10195	COG2814	Major facilitator Superfamily
ES968_RS10205	COG3328	transposase activity
ES968_RS10285	COG3655	Transcriptional regulator
ES968_RS10330	COG0457	Tetratricopeptide repeat
ES968_RS10335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS10345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_RS10370	COG2211	Major facilitator Superfamily
ES968_RS10375	COG3328	transposase activity
ES968_RS10405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_RS10425	COG5444	nuclease activity
ES968_RS10430	COG4282	regulation of fungal-type cell wall biogenesis
ES968_RS10435	COG1231	oxidoreductase activity
ES968_RS10440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_RS10445	COG2207	Transcriptional regulator
ES968_RS10445	COG0662	Cupin 2, conserved barrel domain protein
ES968_RS10450	COG0456	acetyltransferase
ES968_RS10455	COG1309	transcriptional regulator
ES968_RS10460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS10465	COG3708	Transcriptional regulator
ES968_RS10470	COG2378	regulation of single-species biofilm formation
ES968_RS10480	COG0640	Transcriptional regulator
ES968_RS10485	COG0741	lytic transglycosylase activity
ES968_RS10490	COG2322	membrane
ES968_RS10505	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES968_RS10510	COG3239	Fatty acid desaturase
ES968_RS10515	COG4585	Histidine kinase
ES968_RS10520	COG2197	response regulator
ES968_RS10525	COG3584	3D domain protein
ES968_RS10525	COG1388	LysM domain
ES968_RS10530	COG0514	ATP-dependent DNA helicase (RecQ)
ES968_RS10540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES968_RS10545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_RS10560	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_RS10585	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS10590	COG1657	PFAM Prenyltransferase squalene oxidase
ES968_RS10600	COG0733	neurotransmitter:sodium symporter activity
ES968_RS10605	COG0385	Bile acid
ES968_RS10610	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_RS10615	COG0567	Dehydrogenase, E1 component
ES968_RS10620	COG4548	von Willebrand factor, type A
ES968_RS10625	COG0714	Associated with various cellular activities
ES968_RS10630	COG2032	superoxide dismutase activity
ES968_RS10635	COG1388	LysM domain
ES968_RS10635	COG0791	NLP P60 protein
ES968_RS10640	COG1819	glycosyl
ES968_RS10645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES968_RS10650	COG0534	Mate efflux family protein
ES968_RS10655	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS10660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_RS10665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_RS10695	COG1942	4-Oxalocrotonate Tautomerase
ES968_RS10700	COG1733	regulation of RNA biosynthetic process
ES968_RS10705	COG0778	Nitroreductase
ES968_RS10715	COG0400	carboxylic ester hydrolase activity
ES968_RS10720	COG0346	lactoylglutathione lyase activity
ES968_RS10730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_RS10735	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS10735	COG0793	Belongs to the peptidase S41A family
ES968_RS10740	COG2226	methyltransferase
ES968_RS10750	COG1876	peptidase activity
ES968_RS10755	COG0813	purine-nucleoside phosphorylase activity
ES968_RS10770	COG0671	phosphoesterase, PA-phosphatase related
ES968_RS10795	COG4479	Belongs to the UPF0346 family
ES968_RS10805	COG1509	lysine 2,3-aminomutase activity
ES968_RS10810	COG0456	acetyltransferase
ES968_RS10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_RS10820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES968_RS10825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES968_RS10830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_RS10845	COG0456	acetyltransferase
ES968_RS10850	COG0463	Glycosyl transferase, family 2
ES968_RS10865	COG4641	Protein conserved in bacteria
ES968_RS10870	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES968_RS10875	COG1086	Polysaccharide biosynthesis protein
ES968_RS10880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES968_RS10885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES968_RS10890	COG1846	Transcriptional regulator
ES968_RS10895	COG0534	Mate efflux family protein
ES968_RS10905	COG4698	Protein conserved in bacteria
ES968_RS10910	COG2755	lipolytic protein G-D-S-L family
ES968_RS10915	COG1999	signal sequence binding
ES968_RS10925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES968_RS10930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES968_RS10935	COG1272	protein, Hemolysin III
ES968_RS10940	COG0204	Acyl-transferase
ES968_RS10945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_RS10950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES968_RS10960	COG2521	methyltransferase
ES968_RS10960	COG2136	Putative SAM-dependent methyltransferase
ES968_RS10970	COG0129	dihydroxy-acid dehydratase activity
ES968_RS10975	COG1413	lyase activity
ES968_RS10980	COG1418	mRNA catabolic process
ES968_RS10985	COG0386	Belongs to the glutathione peroxidase family
ES968_RS10990	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES968_RS10995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_RS11005	COG1278	Cold shock
ES968_RS11025	COG0328	RNA-DNA hybrid ribonuclease activity
ES968_RS11030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES968_RS11035	COG0328	RNA-DNA hybrid ribonuclease activity
ES968_RS11045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_RS11060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES968_RS11070	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES968_RS11080	COG2233	PERMEase
ES968_RS11085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_RS11090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES968_RS11100	COG0800	Aldolase
ES968_RS11105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_RS11110	COG1609	Transcriptional regulator
ES968_RS11115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES968_RS11120	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS11125	COG1199	ATP-dependent helicase activity
ES968_RS11140	COG0116	Belongs to the methyltransferase superfamily
ES968_RS11155	COG4474	Belongs to the UPF0398 family
ES968_RS11170	COG3359	exonuclease
ES968_RS11175	COG1205	dead DEAH box helicase
ES968_RS11175	COG1111	helicase
ES968_RS11180	COG2190	(PTS) system
ES968_RS11185	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_RS11220	COG3331	DNA recombination
ES968_RS11225	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES968_RS11225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_RS11235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES968_RS11240	COG3935	DnaD domain protein
ES968_RS11245	COG0017	Asparaginyl-tRNA synthetase
ES968_RS11250	COG0436	Aminotransferase
ES968_RS11255	COG5353	protein conserved in bacteria
ES968_RS11265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES968_RS11265	COG1199	ATP-dependent helicase activity
ES968_RS11270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES968_RS11275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES968_RS11280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES968_RS11285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES968_RS11285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES968_RS11290	COG0617	tRNA 3'-terminal CCA addition
ES968_RS11295	COG0438	transferase activity, transferring glycosyl groups
ES968_RS11300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_RS11305	COG1803	Methylglyoxal synthase
ES968_RS11310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES968_RS11315	COG1694	Mazg nucleotide pyrophosphohydrolase
ES968_RS11320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS11330	COG4347	Protein of unknown function (DUF1405)
ES968_RS11335	COG2010	Cytochrome c
ES968_RS11335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES968_RS11340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES968_RS11345	COG0723	plastoquinol--plastocyanin reductase activity
ES968_RS11355	COG5582	Belongs to the UPF0302 family
ES968_RS11360	COG0457	Tetratricopeptide repeat
ES968_RS11365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES968_RS11370	COG0287	Prephenate dehydrogenase
ES968_RS11375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ES968_RS11380	COG0159	tryptophan synthase activity
ES968_RS11385	COG0133	tryptophan synthase activity
ES968_RS11390	COG0135	phosphoribosylanthranilate isomerase activity
ES968_RS11400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES968_RS11405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES968_RS11410	COG4401	Chorismate mutase type I
ES968_RS11415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES968_RS11420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES968_RS11425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES968_RS11430	COG0105	UTP biosynthetic process
ES968_RS11435	COG0142	geranyltranstransferase activity
ES968_RS11440	COG2226	methyltransferase
ES968_RS11445	COG0142	geranyltranstransferase activity
ES968_RS11455	COG0302	gtp cyclohydrolase
ES968_RS11460	COG0776	regulation of translation
ES968_RS11465	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES968_RS11480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES968_RS11485	COG1160	GTP binding
ES968_RS11510	COG1304	FMN binding
ES968_RS11515	COG0539	negative regulation of cytoplasmic translation
ES968_RS11520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES968_RS11530	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES968_RS11535	COG2959	enzyme of heme biosynthesis
ES968_RS11540	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS11540	COG3773	Cell wall hydrolase
ES968_RS11545	COG2339	peptidase activity
ES968_RS11550	COG0492	ferredoxin-NADP+ reductase activity
ES968_RS11555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_RS11560	COG4862	establishment of competence for transformation
ES968_RS11565	COG1408	metallophosphoesterase
ES968_RS11575	COG1388	LysM domain
ES968_RS11580	COG1266	CAAX protease self-immunity
ES968_RS11585	COG0514	ATP-dependent DNA helicase (RecQ)
ES968_RS11590	COG4955	Helix-turn-helix domain
ES968_RS11595	COG1141	Ferredoxin
ES968_RS11600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES968_RS11605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES968_RS11610	COG0710	3-dehydroquinate dehydratase activity
ES968_RS11620	COG1595	DNA-templated transcription, initiation
ES968_RS11625	COG5002	protein histidine kinase activity
ES968_RS11630	COG0745	RESPONSE REGULATOR receiver
ES968_RS11635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES968_RS11640	COG1333	cytochrome c biogenesis protein
ES968_RS11645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS11650	COG1187	pseudouridine synthase activity
ES968_RS11655	COG0700	Nucleoside recognition
ES968_RS11660	COG2715	membrane protein required for spore maturation
ES968_RS11665	COG1686	Belongs to the peptidase S11 family
ES968_RS11675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES968_RS11680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES968_RS11685	COG1547	Domain of unknown function (DUF309)
ES968_RS11690	COG0456	acetyltransferase
ES968_RS11695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES968_RS11700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES968_RS11700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES968_RS11705	COG0307	riboflavin synthase, alpha
ES968_RS11710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES968_RS11710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES968_RS11720	COG0681	Belongs to the peptidase S26 family
ES968_RS11730	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES968_RS11780	COG3328	transposase activity
ES968_RS11785	COG3012	SEC-C Motif Domain Protein
ES968_RS11795	COG0457	Tetratricopeptide repeat
ES968_RS11850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES968_RS11860	COG4086	secreted protein
ES968_RS11865	COG0019	diaminopimelate decarboxylase activity
ES968_RS11870	COG0697	spore germination
ES968_RS11885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_RS11905	COG1191	sigma factor activity
ES968_RS11910	COG2172	sigma factor antagonist activity
ES968_RS11915	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS11920	COG1686	Belongs to the peptidase S11 family
ES968_RS11925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES968_RS11930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES968_RS11935	COG4974	Belongs to the 'phage' integrase family
ES968_RS11945	COG0735	belongs to the Fur family
ES968_RS11950	COG1300	Membrane
ES968_RS11960	COG0281	malic enzyme
ES968_RS11965	COG1757	Na H antiporter
ES968_RS11970	COG1027	Aspartate ammonia-lyase
ES968_RS11975	COG0252	asparaginase activity
ES968_RS11980	COG1396	sequence-specific DNA binding
ES968_RS11985	COG1379	DNA repair
ES968_RS11990	COG0494	nUDIX hydrolase
ES968_RS12000	COG0667	Aldo Keto reductase
ES968_RS12010	COG1073	alpha beta
ES968_RS12020	COG4918	Iron-sulphur cluster biosynthesis
ES968_RS12025	COG0456	acetyltransferase
ES968_RS12025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES968_RS12030	COG2329	Antibiotic biosynthesis monooxygenase
ES968_RS12035	COG0456	acetyltransferase
ES968_RS12045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_RS12055	COG2211	Major facilitator Superfamily
ES968_RS12060	COG0346	lactoylglutathione lyase activity
ES968_RS12065	COG1072	(Pantothenic acid kinase))
ES968_RS12070	COG3048	D-serine ammonia-lyase activity
ES968_RS12075	COG0300	oxidoreductase activity
ES968_RS12080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS12085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_RS12090	COG4187	Peptidase family M20/M25/M40
ES968_RS12095	COG1902	pentaerythritol trinitrate reductase activity
ES968_RS12100	COG0596	Alpha beta hydrolase
ES968_RS12110	COG1234	tRNA 3'-trailer cleavage
ES968_RS12115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES968_RS12120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES968_RS12125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_RS12135	COG0706	membrane insertase activity
ES968_RS12140	COG3361	conserved protein (COG2071)
ES968_RS12145	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES968_RS12150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES968_RS12155	COG0346	lactoylglutathione lyase activity
ES968_RS12160	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_RS12165	COG4129	membrane
ES968_RS12170	COG1126	abc transporter atp-binding protein
ES968_RS12175	COG0765	amino acid transport
ES968_RS12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_RS12190	COG1597	lipid kinase activity
ES968_RS12200	COG4978	Transcriptional regulator
ES968_RS12200	COG0789	Transcriptional regulator
ES968_RS12205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_RS12210	COG0022	dehydrogenase e1 component
ES968_RS12215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_RS12220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_RS12225	COG3426	butyrate kinase activity
ES968_RS12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_RS12235	COG0280	phosphate acetyltransferase
ES968_RS12240	COG3829	transcription factor binding
ES968_RS12240	COG3290	protein histidine kinase activity
ES968_RS12250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES968_RS12255	COG2079	MmgE PrpD family protein
ES968_RS12260	COG0372	Belongs to the citrate synthase family
ES968_RS12265	COG1960	acyl-CoA dehydrogenase activity
ES968_RS12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES968_RS12275	COG0183	Belongs to the thiolase family
ES968_RS12280	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_RS12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS12300	COG1902	pentaerythritol trinitrate reductase activity
ES968_RS12305	COG0745	RESPONSE REGULATOR receiver
ES968_RS12315	COG0750	zinc metalloprotease
ES968_RS12320	COG0497	DNA recombination
ES968_RS12325	COG1438	arginine binding
ES968_RS12330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES968_RS12335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES968_RS12340	COG0142	geranyltranstransferase activity
ES968_RS12345	COG1722	exodeoxyribonuclease VII activity
ES968_RS12350	COG1570	exodeoxyribonuclease VII activity
ES968_RS12355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES968_RS12360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES968_RS12365	COG1302	Protein conserved in bacteria
ES968_RS12370	COG0439	Biotin carboxylase
ES968_RS12375	COG0511	ligase activity, forming carbon-carbon bonds
ES968_RS12415	COG3854	ATPases associated with a variety of cellular activities
ES968_RS12425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES968_RS12430	COG0006	proline dipeptidase activity
ES968_RS12435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES968_RS12445	COG3872	metal-dependent enzyme
ES968_RS12455	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES968_RS12460	COG1321	iron dependent repressor
ES968_RS12465	COG0095	Lipoate-protein ligase
ES968_RS12470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES968_RS12475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES968_RS12480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES968_RS12485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES968_RS12490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES968_RS12505	COG1396	sequence-specific DNA binding
ES968_RS12515	COG0681	Belongs to the peptidase S26 family
ES968_RS12540	COG4940	Competence protein ComGF
ES968_RS12550	COG4970	Tfp pilus assembly protein FimT
ES968_RS12555	COG4537	Required for transformation and DNA binding
ES968_RS12560	COG1459	type II secretion system
ES968_RS12565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES968_RS12570	COG0517	IMP dehydrogenase activity
ES968_RS12575	COG0598	Magnesium transport protein CorA
ES968_RS12580	COG1253	flavin adenine dinucleotide binding
ES968_RS12585	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS12595	COG1393	Belongs to the ArsC family
ES968_RS12605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS12615	COG0011	TIGRFAM Protein of
ES968_RS12625	COG2866	Carboxypeptidase
ES968_RS12630	COG1368	sulfuric ester hydrolase activity
ES968_RS12635	COG1940	carbohydrate kinase activity
ES968_RS12640	COG4483	Protein conserved in bacteria
ES968_RS12645	COG0457	Tetratricopeptide repeat
ES968_RS12645	COG0705	Rhomboid family
ES968_RS12655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES968_RS12665	COG0438	transferase activity, transferring glycosyl groups
ES968_RS12680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES968_RS12685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_RS12690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_RS12695	COG0581	inorganic phosphate transmembrane transporter activity
ES968_RS12700	COG0573	inorganic phosphate transmembrane transporter activity
ES968_RS12705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES968_RS12710	COG0768	penicillin binding
ES968_RS12715	COG0477	Major facilitator Superfamily
ES968_RS12720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES968_RS12725	COG2839	Protein conserved in bacteria
ES968_RS12730	COG5521	maltodextrose utilization protein MalA
ES968_RS12735	COG1388	LysM domain
ES968_RS12740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES968_RS12745	COG4709	membrane
ES968_RS12750	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES968_RS12755	COG0735	belongs to the Fur family
ES968_RS12760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS12770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES968_RS12775	COG0513	Belongs to the DEAD box helicase family
ES968_RS12785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES968_RS12790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES968_RS12795	COG2384	SAM-dependent methyltransferase
ES968_RS12800	COG2010	Cytochrome c
ES968_RS12810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES968_RS12815	COG0358	DNA primase activity
ES968_RS12820	COG1671	Belongs to the UPF0178 family
ES968_RS12825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES968_RS12830	COG0517	IMP dehydrogenase activity
ES968_RS12835	COG0751	glycine-tRNA ligase activity
ES968_RS12840	COG0752	glycyl-tRNA synthetase alpha subunit
ES968_RS12845	COG1381	Involved in DNA repair and RecF pathway recombination
ES968_RS12855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES968_RS12860	COG0295	cytidine deaminase activity
ES968_RS12865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES968_RS12870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES968_RS12875	COG1480	7TM receptor with intracellular HD hydrolase
ES968_RS12880	COG1702	phosphate starvation-inducible protein PhoH
ES968_RS12885	COG0561	phosphatase activity
ES968_RS12900	COG4864	UPF0365 protein
ES968_RS12905	COG1030	water channel activity
ES968_RS12910	COG1610	YqeY-like protein
ES968_RS12920	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES968_RS12925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES968_RS12930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES968_RS12935	COG2264	protein methyltransferase activity
ES968_RS12940	COG0484	heat shock protein binding
ES968_RS12945	COG0443	Heat shock 70 kDa protein
ES968_RS12950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES968_RS12955	COG1420	regulation of RNA biosynthetic process
ES968_RS12960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES968_RS12965	COG0481	GTPase activity
ES968_RS12975	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS12980	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES968_RS12985	COG0268	Binds directly to 16S ribosomal RNA
ES968_RS12990	COG1466	dna polymerase III delta subunit
ES968_RS13005	COG0658	competence protein
ES968_RS13005	COG2333	competence protein COMEC
ES968_RS13010	COG2131	deaminase
ES968_RS13015	COG1596	polysaccharide export
ES968_RS13015	COG1555	photosystem II stabilization
ES968_RS13020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_RS13025	COG2226	methyltransferase
ES968_RS13030	COG0799	negative regulation of ribosome biogenesis
ES968_RS13035	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES968_RS13040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES968_RS13045	COG1534	Rna-binding protein
ES968_RS13050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES968_RS13055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES968_RS13060	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES968_RS13070	COG2755	lipolytic protein G-D-S-L family
ES968_RS13075	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_RS13075	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS13080	COG0398	Pfam SNARE associated Golgi protein
ES968_RS13085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES968_RS13095	COG3209	COG3209 Rhs family protein
ES968_RS13115	COG0114	fumarate hydratase activity
ES968_RS13120	COG0583	DNA-binding transcription factor activity
ES968_RS13135	COG0457	Tetratricopeptide repeat
ES968_RS13270	COG0789	Transcriptional regulator
ES968_RS13270	COG4978	Transcriptional regulator
ES968_RS13275	COG2814	Major facilitator Superfamily
ES968_RS13280	COG0456	acetyltransferase
ES968_RS13285	COG3328	transposase activity
ES968_RS13295	COG1253	flavin adenine dinucleotide binding
ES968_RS13305	COG0697	spore germination
ES968_RS13310	COG0583	DNA-binding transcription factor activity
ES968_RS13315	COG2072	flavoprotein involved in K transport
ES968_RS13320	COG1230	cation diffusion facilitator family transporter
ES968_RS13330	COG1114	Component of the transport system for branched-chain amino acids
ES968_RS13335	COG1687	branched-chain amino acid
ES968_RS13340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES968_RS13345	COG1522	sequence-specific DNA binding
ES968_RS13350	COG2732	(Barnase) inhibitor
ES968_RS13360	COG1335	isochorismatase
ES968_RS13375	COG2318	DinB family
ES968_RS13385	COG2070	2-Nitropropane dioxygenase
ES968_RS13400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES968_RS13420	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES968_RS13425	COG1595	DNA-templated transcription, initiation
ES968_RS13435	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS13440	COG5566	PFAM Mor transcription activator
ES968_RS13445	COG0596	Alpha beta hydrolase
ES968_RS13450	COG4991	sh3 domain protein
ES968_RS13455	COG4991	sh3 domain protein
ES968_RS13465	COG0346	lactoylglutathione lyase activity
ES968_RS13475	COG5577	PFAM Coat F domain
ES968_RS13480	COG1063	alcohol dehydrogenase
ES968_RS13490	COG5577	PFAM Coat F domain
ES968_RS13495	COG0789	Transcriptional regulator
ES968_RS13505	COG1064	alcohol dehydrogenase
ES968_RS13510	COG0693	protein deglycase activity
ES968_RS13515	COG1621	beta-fructofuranosidase activity
ES968_RS13520	COG3716	PTS system mannose fructose sorbose family IID component
ES968_RS13525	COG3715	PTS system
ES968_RS13530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS13535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS13540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES968_RS13540	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES968_RS13550	COG1113	amino acid transport
ES968_RS13555	COG1280	lysine exporter protein (LysE YggA)
ES968_RS13560	COG1378	Sugar-specific transcriptional regulator TrmB
ES968_RS13575	COG2755	lipolytic protein G-D-S-L family
ES968_RS13575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES968_RS13585	COG2124	cytochrome p450
ES968_RS13585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_RS13590	COG1309	transcriptional regulator
ES968_RS13595	COG2226	methyltransferase
ES968_RS13610	COG2116	formate transmembrane transporter activity
ES968_RS13615	COG5609	conserved protein (DUF2294)
ES968_RS13620	COG3383	formate dehydrogenase (NAD+) activity
ES968_RS13625	COG2427	Protein of unknown function (DUF1641)
ES968_RS13635	COG0626	cystathionine gamma-synthase activity
ES968_RS13640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_RS13645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES968_RS13650	COG2226	methyltransferase
ES968_RS13665	COG0768	penicillin binding
ES968_RS13670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES968_RS13675	COG0572	uridine kinase
ES968_RS13680	COG0826	peptidase U32
ES968_RS13685	COG0826	peptidase U32
ES968_RS13690	COG4122	O-methyltransferase activity
ES968_RS13695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES968_RS13700	COG3906	Belongs to the UPF0473 family
ES968_RS13705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES968_RS13710	COG4472	Bacterial protein of unknown function (DUF965)
ES968_RS13715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES968_RS13720	COG0628	permease
ES968_RS13725	COG1126	abc transporter atp-binding protein
ES968_RS13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_RS13735	COG0765	amino acid transport
ES968_RS13740	COG0765	amino acid transport
ES968_RS13755	COG3881	PFAM PRC-barrel domain
ES968_RS13760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES968_RS13765	COG0457	Tetratricopeptide repeat
ES968_RS13770	COG0482	sulfurtransferase activity
ES968_RS13775	COG1104	cysteine desulfurase activity
ES968_RS13780	COG1959	2 iron, 2 sulfur cluster binding
ES968_RS13785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES968_RS13790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES968_RS13800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES968_RS13805	COG0124	histidyl-tRNA synthetase
ES968_RS13815	COG4991	sh3 domain protein
ES968_RS13815	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS13815	COG3103	Sh3 type 3 domain protein
ES968_RS13820	COG1490	D-aminoacyl-tRNA deacylase activity
ES968_RS13825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES968_RS13830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_RS13835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES968_RS13835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES968_RS13840	COG5416	Lipopolysaccharide assembly protein A domain
ES968_RS13845	COG0490	domain, Protein
ES968_RS13850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES968_RS13850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES968_RS13860	COG2244	polysaccharide biosynthetic process
ES968_RS13865	COG2323	membrane
ES968_RS13875	COG1862	Preprotein translocase
ES968_RS13880	COG0343	queuine tRNA-ribosyltransferase activity
ES968_RS13885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES968_RS13895	COG2255	four-way junction helicase activity
ES968_RS13900	COG0632	four-way junction helicase activity
ES968_RS13910	COG2814	Major facilitator Superfamily
ES968_RS13915	COG0673	inositol 2-dehydrogenase activity
ES968_RS13920	COG2112	serine threonine protein kinase
ES968_RS13940	COG1115	amino acid carrier protein
ES968_RS13945	COG0217	transcriptional regulatory protein
ES968_RS13955	COG1388	LysM domain
ES968_RS13960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES968_RS13965	COG0157	Belongs to the NadC ModD family
ES968_RS13970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES968_RS13975	COG1104	cysteine desulfurase activity
ES968_RS13980	COG1827	regulation of RNA biosynthetic process
ES968_RS13985	COG0077	Prephenate dehydratase
ES968_RS13990	COG4492	Belongs to the UPF0735 family
ES968_RS13995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES968_RS14000	COG3290	protein histidine kinase activity
ES968_RS14010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES968_RS14015	COG2868	ribosomal protein
ES968_RS14020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES968_RS14025	COG1994	Peptidase M50
ES968_RS14030	COG0739	heme binding
ES968_RS14035	COG2894	cell division
ES968_RS14040	COG0850	regulation of cytokinetic process
ES968_RS14045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES968_RS14055	COG1077	Cell shape determining protein MreB Mrl
ES968_RS14060	COG2003	Belongs to the UPF0758 family
ES968_RS14065	COG0424	maF-like protein
ES968_RS14075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES968_RS14080	COG0285	dihydrofolate synthase activity
ES968_RS14085	COG0525	valine-tRNA ligase activity
ES968_RS14095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_RS14100	COG1388	LysM domain
ES968_RS14105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES968_RS14110	COG0113	porphobilinogen synthase activity
ES968_RS14115	COG1587	Uroporphyrinogen-III synthase
ES968_RS14120	COG0181	hydroxymethylbilane synthase activity
ES968_RS14125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES968_RS14130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES968_RS14140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES968_RS14145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES968_RS14150	COG0470	DNA polymerase III
ES968_RS14150	COG1067	ATP-dependent peptidase activity
ES968_RS14155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES968_RS14160	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES968_RS14165	COG1477	protein flavinylation
ES968_RS14165	COG0457	Tetratricopeptide repeat
ES968_RS14170	COG0066	3-isopropylmalate dehydratase activity
ES968_RS14175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES968_RS14180	COG0473	3-isopropylmalate dehydrogenase activity
ES968_RS14185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES968_RS14190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES968_RS14195	COG0440	acetolactate synthase activity
ES968_RS14200	COG0028	Belongs to the TPP enzyme family
ES968_RS14215	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES968_RS14240	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ES968_RS14265	COG0622	Phosphoesterase
ES968_RS14270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES968_RS14275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES968_RS14280	COG5401	PFAM Sporulation and spore germination
ES968_RS14285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES968_RS14290	COG1846	Transcriptional regulator
ES968_RS14295	COG2197	response regulator
ES968_RS14300	COG0824	Thioesterase
ES968_RS14305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES968_RS14310	COG1053	succinate dehydrogenase
ES968_RS14315	COG2009	succinate dehydrogenase
ES968_RS14320	COG1719	4-vinyl reductase, 4VR
ES968_RS14325	COG0527	aspartate kinase activity
ES968_RS14335	COG0322	excinuclease ABC activity
ES968_RS14340	COG3118	belongs to the thioredoxin family
ES968_RS14350	COG3534	alpha-L-arabinofuranosidase
ES968_RS14355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES968_RS14360	COG2086	electron transfer activity
ES968_RS14365	COG1024	Enoyl-CoA hydratase
ES968_RS14370	COG1309	transcriptional regulator
ES968_RS14375	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS14380	COG3766	membrane
ES968_RS14385	COG1193	negative regulation of DNA recombination
ES968_RS14390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES968_RS14390	COG1796	DNA polymerase
ES968_RS14395	COG1286	toxin biosynthetic process
ES968_RS14400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES968_RS14405	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES968_RS14410	COG0072	phenylalanine-tRNA ligase activity
ES968_RS14410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_RS14415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES968_RS14425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES968_RS14435	COG3835	regulator
ES968_RS14440	COG0277	FAD linked oxidase domain protein
ES968_RS14445	COG0247	lactate metabolic process
ES968_RS14450	COG0346	lactoylglutathione lyase activity
ES968_RS14460	COG1966	Carbon starvation protein
ES968_RS14465	COG3534	alpha-L-arabinofuranosidase
ES968_RS14470	COG0395	ABC-type sugar transport system, permease component
ES968_RS14475	COG1175	transmembrane transport
ES968_RS14480	COG1653	transport
ES968_RS14485	COG0371	Dehydrogenase
ES968_RS14490	COG0647	UMP catabolic process
ES968_RS14495	COG0235	Class ii aldolase
ES968_RS14500	COG1069	ribulokinase activity
ES968_RS14505	COG2160	L-arabinose isomerase activity
ES968_RS14515	COG1363	Peptidase, m42
ES968_RS14525	COG3326	Membrane
ES968_RS14530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES968_RS14535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES968_RS14540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES968_RS14550	COG1346	cytolysis
ES968_RS14555	COG1380	Effector of murein hydrolase LrgA
ES968_RS14560	COG3279	Response regulator of the LytR AlgR family
ES968_RS14565	COG3275	phosphorelay sensor kinase activity
ES968_RS14570	COG1011	Hydrolase
ES968_RS14575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES968_RS14585	COG0398	Pfam SNARE associated Golgi protein
ES968_RS14590	COG1484	DNA-dependent DNA replication
ES968_RS14595	COG3611	Membrane attachment protein
ES968_RS14600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES968_RS14605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES968_RS14610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES968_RS14615	COG1733	regulation of RNA biosynthetic process
ES968_RS14620	COG2814	Major facilitator Superfamily
ES968_RS14625	COG0656	L-ascorbic acid biosynthetic process
ES968_RS14630	COG0237	dephospho-CoA kinase activity
ES968_RS14635	COG1971	Probably functions as a manganese efflux pump
ES968_RS14640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES968_RS14645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_RS14645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_RS14650	COG5002	protein histidine kinase activity
ES968_RS14655	COG0745	RESPONSE REGULATOR receiver
ES968_RS14660	COG0039	L-malate dehydrogenase activity
ES968_RS14665	COG0538	isocitrate dehydrogenase activity
ES968_RS14670	COG0372	Belongs to the citrate synthase family
ES968_RS14675	COG2707	UPF0756 membrane protein
ES968_RS14680	COG0628	permease
ES968_RS14685	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES968_RS14690	COG0469	pyruvate kinase activity
ES968_RS14695	COG0205	6-phosphofructokinase activity
ES968_RS14700	COG0825	malonyl-CoA metabolic process
ES968_RS14705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES968_RS14710	COG0281	malic enzyme
ES968_RS14715	COG0587	DNA-directed DNA polymerase activity
ES968_RS14735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES968_RS14745	COG4109	DRTGG domain
ES968_RS14750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES968_RS14755	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS14765	COG0165	Argininosuccinate lyase
ES968_RS14770	COG0137	argininosuccinate synthase activity
ES968_RS14775	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES968_RS14780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES968_RS14790	COG0827	DNA restriction-modification system
ES968_RS14795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES968_RS14800	COG3874	Sporulation protein YtfJ
ES968_RS14810	COG1714	RDD family
ES968_RS14815	COG0616	signal peptide processing
ES968_RS14820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES968_RS14825	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES968_RS14830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES968_RS14840	COG0301	tRNA thio-modification
ES968_RS14845	COG1104	cysteine desulfurase activity
ES968_RS14850	COG1114	Component of the transport system for branched-chain amino acids
ES968_RS14855	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES968_RS14860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES968_RS14865	COG1309	transcriptional regulator
ES968_RS14870	COG1956	GAF domain-containing protein
ES968_RS14875	COG2199	diguanylate cyclase activity
ES968_RS14875	COG2203	Gaf domain
ES968_RS14885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES968_RS14890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES968_RS14895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES968_RS14900	COG0454	-acetyltransferase
ES968_RS14905	COG0517	IMP dehydrogenase activity
ES968_RS14910	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES968_RS14915	COG1360	Flagellar Motor Protein
ES968_RS14920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES968_RS14925	COG1609	Transcriptional regulator
ES968_RS14930	COG1605	Chorismate mutase
ES968_RS14930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES968_RS14935	COG3118	belongs to the thioredoxin family
ES968_RS14940	COG4980	gas vesicle protein
ES968_RS14945	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES968_RS14950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES968_RS14955	COG1674	ftsk spoiiie
ES968_RS14960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_RS14965	COG4848	Belongs to the UPF0354 family
ES968_RS14970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS14985	COG1363	Peptidase, m42
ES968_RS14990	COG5584	Small secreted protein
ES968_RS14995	COG0281	malic enzyme
ES968_RS15000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_RS15005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES968_RS15015	COG0510	thiamine kinase activity
ES968_RS15020	COG1523	belongs to the glycosyl hydrolase 13 family
ES968_RS15025	COG1597	lipid kinase activity
ES968_RS15035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES968_RS15040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_RS15045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_RS15050	COG2252	PERMEase
ES968_RS15055	COG4473	ABC transporter
ES968_RS15060	COG1131	(ABC) transporter
ES968_RS15065	COG1349	DNA-binding transcription factor activity
ES968_RS15070	COG1187	pseudouridine synthase activity
ES968_RS15075	COG2244	polysaccharide biosynthetic process
ES968_RS15080	COG2081	HI0933 family
ES968_RS15085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES968_RS15105	COG1653	transport
ES968_RS15110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES968_RS15115	COG4209	transmembrane transport
ES968_RS15125	COG1653	transport
ES968_RS15130	COG0395	ABC-type sugar transport system, permease component
ES968_RS15135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_RS15140	COG2124	cytochrome p450
ES968_RS15145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES968_RS15160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_RS15170	COG1073	alpha beta
ES968_RS15175	COG1609	Transcriptional regulator
ES968_RS15180	COG1653	transport
ES968_RS15185	COG1175	transmembrane transport
ES968_RS15190	COG0395	ABC-type sugar transport system, permease component
ES968_RS15195	COG1486	melibiose metabolic process
ES968_RS15200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES968_RS15205	COG0495	leucyl-tRNA aminoacylation
ES968_RS15215	COG2202	Pas domain
ES968_RS15215	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_RS15220	COG2814	Major facilitator Superfamily
ES968_RS15225	COG2433	Pfam Transposase IS66
ES968_RS15230	COG0577	efflux transmembrane transporter activity
ES968_RS15235	COG1136	(ABC) transporter
ES968_RS15240	COG2205	protein histidine kinase activity
ES968_RS15245	COG0745	RESPONSE REGULATOR receiver
ES968_RS15250	COG0577	efflux transmembrane transporter activity
ES968_RS15255	COG1136	(ABC) transporter
ES968_RS15270	COG1131	(ABC) transporter
ES968_RS15275	COG1725	Transcriptional regulator
ES968_RS15290	COG1242	4 iron, 4 sulfur cluster binding
ES968_RS15295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES968_RS15305	COG2267	carboxylic ester hydrolase activity
ES968_RS15310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES968_RS15315	COG1113	amino acid transport
ES968_RS15320	COG0367	asparagine synthase
ES968_RS15325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES968_RS15330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES968_RS15340	COG1506	peptidase
ES968_RS15345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES968_RS15350	COG1116	anion transmembrane transporter activity
ES968_RS15355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES968_RS15360	COG0494	nUDIX hydrolase
ES968_RS15365	COG4824	toxin secretion phage lysis holin
ES968_RS15370	COG0783	Belongs to the Dps family
ES968_RS15385	COG1854	S-ribosylhomocysteine lyase activity
ES968_RS15390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES968_RS15395	COG0288	reversible hydration of carbon dioxide
ES968_RS15400	COG0254	rRNA binding
ES968_RS15405	COG1271	oxidase subunit
ES968_RS15410	COG1294	oxidase, subunit
ES968_RS15420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_RS15425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_RS15425	COG1321	iron dependent repressor
ES968_RS15430	COG1121	(ABC) transporter
ES968_RS15435	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES968_RS15440	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_RS15445	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_RS15450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES968_RS15455	COG0596	Alpha beta hydrolase
ES968_RS15460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES968_RS15465	COG1169	isochorismate synthase
ES968_RS15475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_RS15480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_RS15485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_RS15490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_RS15495	COG0438	transferase activity, transferring glycosyl groups
ES968_RS15505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_RS15510	COG0438	transferase activity, transferring glycosyl groups
ES968_RS15515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_RS15520	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES968_RS15530	COG0058	SHG alpha-glucan phosphorylase activity
ES968_RS15535	COG0297	glycogen (starch) synthase activity
ES968_RS15540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES968_RS15545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES968_RS15550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES968_RS15675	COG3859	Proton-coupled thiamine transporter YuaJ
ES968_RS15680	COG1247	-acetyltransferase
ES968_RS15685	COG2268	Band 7 protein
ES968_RS15690	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES968_RS15705	COG1454	alcohol dehydrogenase
ES968_RS15710	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS15715	COG1510	regulation of RNA biosynthetic process
ES968_RS15725	COG0569	domain protein
ES968_RS15730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES968_RS15735	COG4682	membrane
ES968_RS15740	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES968_RS15745	COG0477	Major facilitator Superfamily
ES968_RS15750	COG5553	Cysteine dioxygenase type I
ES968_RS15760	COG1968	undecaprenyl-diphosphatase activity
ES968_RS15765	COG0628	permease
ES968_RS15770	COG0673	inositol 2-dehydrogenase activity
ES968_RS15780	COG3254	rhamnose metabolic process
ES968_RS15785	COG1070	Carbohydrate kinase
ES968_RS15790	COG1349	DNA-binding transcription factor activity
ES968_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS15795	COG3347	Dehydrogenase
ES968_RS15805	COG0840	transmembrane signaling receptor activity
ES968_RS15810	COG0840	transmembrane signaling receptor activity
ES968_RS15820	COG0840	transmembrane signaling receptor activity
ES968_RS15835	COG0432	Pfam Uncharacterised protein family UPF0047
ES968_RS15845	COG0366	Alpha amylase catalytic
ES968_RS15850	COG1253	flavin adenine dinucleotide binding
ES968_RS15855	COG2738	Putative neutral zinc metallopeptidase
ES968_RS15870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES968_RS15885	COG0166	Belongs to the GPI family
ES968_RS15890	COG1979	alcohol dehydrogenase
ES968_RS15895	COG1979	alcohol dehydrogenase
ES968_RS15900	COG2155	Conserved Protein
ES968_RS15905	COG1098	S1 RNA binding domain
ES968_RS15910	COG0436	Aminotransferase
ES968_RS15915	COG1522	sequence-specific DNA binding
ES968_RS15920	COG2267	carboxylic ester hydrolase activity
ES968_RS15930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES968_RS15935	COG2205	protein histidine kinase activity
ES968_RS15945	COG5018	Exonuclease
ES968_RS15955	COG2814	Major facilitator Superfamily
ES968_RS15960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_RS15965	COG3011	Protein conserved in bacteria
ES968_RS15975	COG3290	protein histidine kinase activity
ES968_RS15980	COG4565	transcriptional regulatory protein
ES968_RS15985	COG1744	ABC transporter substrate-binding protein PnrA-like
ES968_RS15990	COG3845	ABC transporter
ES968_RS15995	COG4603	Belongs to the binding-protein-dependent transport system permease family
ES968_RS16000	COG1079	Belongs to the binding-protein-dependent transport system permease family
ES968_RS16005	COG3493	citrate carrier protein
ES968_RS16015	COG2111	Na H antiporter
ES968_RS16015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES968_RS16020	COG2111	Na H antiporter
ES968_RS16025	COG1006	Multisubunit Na H antiporter MnhC subunit
ES968_RS16030	COG0651	ATP synthesis coupled electron transport
ES968_RS16035	COG1863	multisubunit Na H antiporter MnhE subunit
ES968_RS16040	COG2212	antiporter activity
ES968_RS16045	COG1320	monovalent cation:proton antiporter activity
ES968_RS16050	COG2050	protein possibly involved in aromatic compounds catabolism
ES968_RS16055	COG2197	response regulator
ES968_RS16060	COG4585	Histidine kinase
ES968_RS16070	COG0142	geranyltranstransferase activity
ES968_RS16090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES968_RS16095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES968_RS16100	COG1335	isochorismatase
ES968_RS16105	COG5506	Protein of unknown function (DUF1694)
ES968_RS16120	COG0628	permease
ES968_RS16135	COG1418	mRNA catabolic process
ES968_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS16150	COG1511	domain protein
ES968_RS16155	COG1674	ftsk spoiiie
ES968_RS16155	COG0433	COG0433 Predicted ATPase
ES968_RS16160	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES968_RS16165	COG5417	Belongs to the EsaB family
ES968_RS16170	COG4842	Belongs to the WXG100 family
ES968_RS16180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES968_RS16180	COG2508	Transcriptional regulator
ES968_RS16185	COG0686	Belongs to the AlaDH PNT family
ES968_RS16190	COG5634	Uncharacterized conserved protein (DUF2278)
ES968_RS16195	COG3251	PFAM MbtH domain protein
ES968_RS16200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS16205	COG1535	isochorismatase
ES968_RS16205	COG3433	isochorismatase activity
ES968_RS16210	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES968_RS16215	COG1169	isochorismate synthase
ES968_RS16220	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS16225	COG2819	hydrolase of the alpha beta superfamily
ES968_RS16230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES968_RS16235	COG1268	BioY protein
ES968_RS16240	COG2056	Na+-H+ antiporter family
ES968_RS16245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES968_RS16250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES968_RS16255	COG3584	3D domain protein
ES968_RS16270	COG1252	NADH dehydrogenase
ES968_RS16275	COG0492	ferredoxin-NADP+ reductase activity
ES968_RS16285	COG0516	GMP reductase activity
ES968_RS16290	COG2808	Putative FMN-binding domain
ES968_RS16295	COG0456	acetyltransferase
ES968_RS16395	COG0582	viral genome integration into host DNA
ES968_RS16405	COG4974	Belongs to the 'phage' integrase family
ES968_RS16410	COG0316	Belongs to the HesB IscA family
ES968_RS16415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES968_RS16420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_RS16425	COG4844	belongs to the
ES968_RS16430	COG1252	NADH dehydrogenase
ES968_RS16435	COG4837	Protein of unknown function (DUF1462)
ES968_RS16440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES968_RS16445	COG1506	peptidase
ES968_RS16445	COG4946	Tricorn protease homolog
ES968_RS16445	COG0823	Involved in the tonB-independent uptake of proteins
ES968_RS16450	COG0083	homoserine kinase activity
ES968_RS16455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES968_RS16460	COG0460	homoserine dehydrogenase
ES968_RS16465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_RS16470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES968_RS16475	COG0647	UMP catabolic process
ES968_RS16480	COG2445	Protein of unknown function DUF86
ES968_RS16485	COG4470	Protein conserved in bacteria
ES968_RS16495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES968_RS16500	COG0739	heme binding
ES968_RS16510	COG3377	Domain of unknown function (DUF1805)
ES968_RS16515	COG0737	Belongs to the 5'-nucleotidase family
ES968_RS16520	COG0730	response to heat
ES968_RS16525	COG1801	Protein of unknown function DUF72
ES968_RS16535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES968_RS16540	COG2508	Transcriptional regulator
ES968_RS16545	COG2233	PERMEase
ES968_RS16550	COG2233	PERMEase
ES968_RS16555	COG3195	allantoin biosynthetic process
ES968_RS16555	COG3648	Uricase
ES968_RS16560	COG2351	hydroxyisourate hydrolase activity
ES968_RS16570	COG2080	2 iron, 2 sulfur cluster binding
ES968_RS16575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES968_RS16580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES968_RS16585	COG2068	MobA-Related Protein
ES968_RS16590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES968_RS16595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES968_RS16600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_RS16610	COG2356	endonuclease I
ES968_RS16615	COG3842	ATPase activity
ES968_RS16620	COG2188	Transcriptional regulator
ES968_RS16625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_RS16630	COG0395	ABC-type sugar transport system, permease component
ES968_RS16635	COG1175	transmembrane transport
ES968_RS16640	COG1653	transport
ES968_RS16645	COG2222	sugar isomerase
ES968_RS16650	COG0322	excinuclease ABC activity
ES968_RS16655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES968_RS16675	COG0346	lactoylglutathione lyase activity
ES968_RS16680	COG0640	Transcriptional regulator
ES968_RS16690	COG5444	nuclease activity
ES968_RS16700	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS16700	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_RS16705	COG4824	toxin secretion phage lysis holin
ES968_RS16740	COG5412	phage tail tape measure protein
ES968_RS16740	COG3953	SLT domain
ES968_RS16835	COG0582	viral genome integration into host DNA
ES968_RS16915	COG3800	Transcriptional regulator
ES968_RS16915	COG1396	sequence-specific DNA binding
ES968_RS16935	COG0719	Fe-S assembly protein
ES968_RS16940	COG0822	iron-sulfur transferase activity
ES968_RS16945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES968_RS16950	COG0719	Fe-S assembly protein
ES968_RS16955	COG0396	ATPase activity
ES968_RS16970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES968_RS16975	COG1464	Belongs to the NlpA lipoprotein family
ES968_RS16980	COG2011	ABC-type metal ion transport system permease component
ES968_RS16985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES968_RS16995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_RS17000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES968_RS17010	COG0509	glycine decarboxylation via glycine cleavage system
ES968_RS17015	COG1393	Belongs to the ArsC family
ES968_RS17020	COG1960	acyl-CoA dehydrogenase activity
ES968_RS17025	COG0183	Belongs to the thiolase family
ES968_RS17030	COG1024	Enoyl-CoA hydratase
ES968_RS17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES968_RS17040	COG0506	proline dehydrogenase activity
ES968_RS17050	COG5577	PFAM Coat F domain
ES968_RS17055	COG1846	Transcriptional regulator
ES968_RS17060	COG0477	Major facilitator Superfamily
ES968_RS17065	COG1942	4-Oxalocrotonate Tautomerase
ES968_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS17075	COG0583	DNA-binding transcription factor activity
ES968_RS17085	COG1120	ATPase activity
ES968_RS17120	COG1131	(ABC) transporter
ES968_RS17165	COG0783	Belongs to the Dps family
ES968_RS17170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_RS17175	COG0745	RESPONSE REGULATOR receiver
ES968_RS17180	COG2205	protein histidine kinase activity
ES968_RS17180	COG2770	Histidine kinase
ES968_RS17190	COG1309	transcriptional regulator
ES968_RS17195	COG0114	fumarate hydratase activity
ES968_RS17205	COG0697	spore germination
ES968_RS17210	COG0814	amino acid
ES968_RS17220	COG2197	response regulator
ES968_RS17225	COG4585	Histidine kinase
ES968_RS17230	COG4758	membrane
ES968_RS17235	COG3595	metallopeptidase activity
ES968_RS17240	COG1842	Phage shock protein A
ES968_RS17245	COG4758	membrane
ES968_RS17250	COG2814	Major facilitator Superfamily
ES968_RS17255	COG2096	Adenosyltransferase
ES968_RS17260	COG1120	ATPase activity
ES968_RS17265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS17270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS17280	COG3386	PFAM SMP-30 Gluconolaconase
ES968_RS17285	COG2205	protein histidine kinase activity
ES968_RS17290	COG0745	RESPONSE REGULATOR receiver
ES968_RS17300	COG1191	sigma factor activity
ES968_RS17310	COG2140	Oxalate decarboxylase
ES968_RS17320	COG0577	efflux transmembrane transporter activity
ES968_RS17325	COG1136	(ABC) transporter
ES968_RS17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES968_RS17335	COG1120	ATPase activity
ES968_RS17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS17345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_RS17350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS17360	COG0531	amino acid
ES968_RS17375	COG1988	membrane-bound metal-dependent
ES968_RS17380	COG1368	sulfuric ester hydrolase activity
ES968_RS17385	COG1910	domain protein
ES968_RS17390	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES968_RS17395	COG4149	molybdate abc transporter
ES968_RS17400	COG0656	L-ascorbic acid biosynthetic process
ES968_RS17410	COG0025	NhaP-type Na H and K H
ES968_RS17415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_RS17420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_RS17425	COG3973	AAA domain
ES968_RS17435	COG2860	membrane
ES968_RS17440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES968_RS17445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES968_RS17450	COG2217	Heavy metal translocating P-type atpase
ES968_RS17455	COG2217	Heavy metal translocating P-type atpase
ES968_RS17460	COG2608	mercury ion transmembrane transporter activity
ES968_RS17465	COG1937	Protein conserved in bacteria
ES968_RS17470	COG0673	inositol 2-dehydrogenase activity
ES968_RS17475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES968_RS17480	COG1289	transmembrane transporter activity
ES968_RS17490	COG2076	Multidrug Resistance protein
ES968_RS17495	COG1309	transcriptional regulator
ES968_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS17510	COG5444	nuclease activity
ES968_RS17525	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_RS17525	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS17530	COG4824	toxin secretion phage lysis holin
ES968_RS17555	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES968_RS17555	COG3942	CHAP domain
ES968_RS17780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES968_RS17785	COG0557	exoribonuclease II activity
ES968_RS17790	COG1647	Serine aminopeptidase, S33
ES968_RS17795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES968_RS17800	COG0596	Alpha beta hydrolase
ES968_RS17805	COG1476	TRANSCRIPTIONal
ES968_RS17810	COG1396	sequence-specific DNA binding
ES968_RS17815	COG1396	sequence-specific DNA binding
ES968_RS17820	COG1733	regulation of RNA biosynthetic process
ES968_RS17825	COG0840	transmembrane signaling receptor activity
ES968_RS17830	COG1174	glycine betaine transport
ES968_RS17835	COG1732	Glycine betaine
ES968_RS17840	COG1174	glycine betaine transport
ES968_RS17845	COG0517	IMP dehydrogenase activity
ES968_RS17845	COG1125	glycine betaine transport
ES968_RS17850	COG1510	regulation of RNA biosynthetic process
ES968_RS17855	COG1174	glycine betaine transport
ES968_RS17860	COG1732	Glycine betaine
ES968_RS17865	COG1174	glycine betaine transport
ES968_RS17870	COG1125	glycine betaine transport
ES968_RS17870	COG0517	IMP dehydrogenase activity
ES968_RS17875	COG1510	regulation of RNA biosynthetic process
ES968_RS17880	COG2095	MarC family integral membrane protein
ES968_RS17890	COG3064	Membrane
ES968_RS17895	COG4640	response to antibiotic
ES968_RS17900	COG0456	acetyltransferase
ES968_RS17905	COG0148	phosphopyruvate hydratase activity
ES968_RS17910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES968_RS17915	COG0149	triose-phosphate isomerase activity
ES968_RS17920	COG0126	phosphoglycerate kinase activity
ES968_RS17925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES968_RS17930	COG2390	Transcriptional regulator
ES968_RS17935	COG2814	Major facilitator Superfamily
ES968_RS17940	COG1609	Transcriptional regulator
ES968_RS17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_RS17955	COG0583	DNA-binding transcription factor activity
ES968_RS17960	COG0697	spore germination
ES968_RS17965	COG1113	amino acid transport
ES968_RS17975	COG1556	Lactate utilization protein
ES968_RS17980	COG1139	Iron-sulfur cluster binding protein
ES968_RS17985	COG0247	lactate metabolic process
ES968_RS18000	COG2197	response regulator
ES968_RS18005	COG4585	Histidine kinase
ES968_RS18010	COG0842	Transport permease protein
ES968_RS18015	COG1131	(ABC) transporter
ES968_RS18020	COG0596	Alpha beta hydrolase
ES968_RS18025	COG2208	phosphoserine phosphatase activity
ES968_RS18030	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES968_RS18035	COG1874	Beta-galactosidase
ES968_RS18040	COG3833	ABC-type maltose transport systems, permease component
ES968_RS18045	COG1175	transmembrane transport
ES968_RS18050	COG2182	Extracellular solute-binding protein
ES968_RS18055	COG1609	Transcriptional regulator
ES968_RS18060	COG2186	Transcriptional regulator
ES968_RS18065	COG1620	l-lactate permease
ES968_RS18070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES968_RS18080	COG5039	Polysaccharide pyruvyl transferase
ES968_RS18085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_RS18090	COG0110	maltose O-acetyltransferase activity
ES968_RS18095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES968_RS18100	COG2244	polysaccharide biosynthetic process
ES968_RS18105	COG1216	Glycosyl transferase, family 2
ES968_RS18110	COG5039	Polysaccharide pyruvyl transferase
ES968_RS18115	COG1216	Glycosyl transferase, family 2
ES968_RS18125	COG0438	transferase activity, transferring glycosyl groups
ES968_RS18130	COG1215	transferase activity, transferring glycosyl groups
ES968_RS18135	COG0438	transferase activity, transferring glycosyl groups
ES968_RS18140	COG1086	Polysaccharide biosynthesis protein
ES968_RS18145	COG0489	protein tyrosine kinase activity
ES968_RS18150	COG3944	biosynthesis protein
ES968_RS18155	COG1396	sequence-specific DNA binding
ES968_RS18160	COG2272	Belongs to the type-B carboxylesterase lipase family
ES968_RS18170	COG3479	Phenolic acid decarboxylase
ES968_RS18185	COG1794	racemase activity, acting on amino acids and derivatives
ES968_RS18195	COG1621	beta-fructofuranosidase activity
ES968_RS18200	COG1621	beta-fructofuranosidase activity
ES968_RS18205	COG0531	amino acid
ES968_RS18210	COG1309	transcriptional regulator
ES968_RS18215	COG2076	Multidrug Resistance protein
ES968_RS18220	COG2076	Multidrug Resistance protein
ES968_RS18235	COG0740	serine-type endopeptidase activity
ES968_RS18240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES968_RS18245	COG0366	Alpha amylase catalytic
ES968_RS18250	COG1554	hydrolase, family 65, central catalytic
ES968_RS18260	COG3833	ABC-type maltose transport systems, permease component
ES968_RS18265	COG1175	transmembrane transport
ES968_RS18275	COG0366	Alpha amylase catalytic
ES968_RS18280	COG1609	Transcriptional regulator
ES968_RS18285	COG1611	Belongs to the LOG family
ES968_RS18295	COG0659	secondary active sulfate transmembrane transporter activity
ES968_RS18300	COG0288	reversible hydration of carbon dioxide
ES968_RS18305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES968_RS18310	COG0577	efflux transmembrane transporter activity
ES968_RS18315	COG1136	(ABC) transporter
ES968_RS18320	COG5002	protein histidine kinase activity
ES968_RS18325	COG0745	RESPONSE REGULATOR receiver
ES968_RS18335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES968_RS18340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS18345	COG1481	regulation of sporulation
ES968_RS18350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES968_RS18355	COG1660	Displays ATPase and GTPase activities
ES968_RS18360	COG1051	belongs to the nudix hydrolase family
ES968_RS18365	COG0492	ferredoxin-NADP+ reductase activity
ES968_RS18370	COG0791	NLP P60 protein
ES968_RS18370	COG3883	PFAM NLP P60 protein
ES968_RS18375	COG0457	Tetratricopeptide repeat
ES968_RS18380	COG1132	(ABC) transporter
ES968_RS18400	COG0140	phosphoribosyl-ATP diphosphatase activity
ES968_RS18400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES968_RS18405	COG0107	imidazoleglycerol-phosphate synthase activity
ES968_RS18410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES968_RS18415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES968_RS18420	COG0131	Imidazoleglycerol-phosphate dehydratase
ES968_RS18425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES968_RS18430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES968_RS18435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES968_RS18440	COG4990	cell redox homeostasis
ES968_RS18445	COG5297	Belongs to the glycosyl hydrolase family 6
ES968_RS18450	COG0110	maltose O-acetyltransferase activity
ES968_RS18455	COG0546	phosphoglycolate phosphatase activity
ES968_RS18460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES968_RS18465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES968_RS18470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES968_RS18475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES968_RS18480	COG0363	glucosamine-6-phosphate deaminase activity
ES968_RS18485	COG2188	Transcriptional regulator
ES968_RS18490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES968_RS18495	COG1950	PFAM Membrane protein of
ES968_RS18500	COG1983	PspC domain protein
ES968_RS18505	COG3595	metallopeptidase activity
ES968_RS18520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_RS18525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES968_RS18530	COG0556	nucleotide-excision repair
ES968_RS18535	COG4897	Protein conserved in bacteria
ES968_RS18540	COG3848	Pyruvate phosphate dikinase
ES968_RS18540	COG0574	Belongs to the PEP-utilizing enzyme family
ES968_RS18545	COG1309	transcriptional regulator
ES968_RS18550	COG2814	Major facilitator Superfamily
ES968_RS18555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_RS18565	COG0793	Belongs to the peptidase S41A family
ES968_RS18565	COG3409	Peptidoglycan-binding domain 1 protein
ES968_RS18570	COG2177	Part of the ABC transporter FtsEX involved in
ES968_RS18575	COG2884	Cell division ATP-binding protein ftsE
ES968_RS18580	COG2010	Cytochrome c
ES968_RS18585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS18595	COG0653	protein targeting
ES968_RS18600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES968_RS18615	COG1516	flagellar protein fliS
ES968_RS18620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES968_RS18625	COG1334	flagellar protein FlaG
ES968_RS18630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_RS18635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES968_RS18640	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES968_RS18650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_RS18655	COG1256	bacterial-type flagellum assembly
ES968_RS18655	COG4786	Flagellar basal body rod
ES968_RS18660	COG3418	PFAM FlgN family protein
ES968_RS18665	COG2747	anti-sigma28 factor FlgM
ES968_RS18675	COG1040	competence protein
ES968_RS18685	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES968_RS18690	COG1307	EDD domain protein, DegV family
ES968_RS18695	COG2197	response regulator
ES968_RS18700	COG4585	Histidine kinase
ES968_RS18705	COG1739	Uncharacterized protein family UPF0029
ES968_RS18710	COG1316	TRANSCRIPTIONal
ES968_RS18745	COG1131	(ABC) transporter
ES968_RS18755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES968_RS18760	COG0438	transferase activity, transferring glycosyl groups
ES968_RS18765	COG1215	transferase activity, transferring glycosyl groups
ES968_RS18770	COG3206	protein involved in exopolysaccharide biosynthesis
ES968_RS18775	COG3307	-O-antigen
ES968_RS18785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_RS18790	COG0297	glycogen (starch) synthase activity
ES968_RS18790	COG0438	transferase activity, transferring glycosyl groups
ES968_RS18795	COG2244	polysaccharide biosynthetic process
ES968_RS18805	COG2247	cell wall binding repeat
ES968_RS18805	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_RS18810	COG2385	sporulation resulting in formation of a cellular spore
ES968_RS18810	COG2247	cell wall binding repeat
ES968_RS18825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES968_RS18830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_RS18840	COG1134	teichoic acid transport
ES968_RS18845	COG1682	transport, permease protein
ES968_RS18860	COG0463	Glycosyl transferase, family 2
ES968_RS18860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_RS18865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_RS18870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES968_RS18875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES968_RS18880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_RS18885	COG4193	domain, Protein
ES968_RS18890	COG1482	cell wall glycoprotein biosynthetic process
ES968_RS18895	COG0697	spore germination
ES968_RS18900	COG0814	amino acid
ES968_RS18915	COG1316	TRANSCRIPTIONal
ES968_RS18920	COG0561	phosphatase activity
ES968_RS18925	COG0791	NLP P60 protein
ES968_RS18935	COG2843	Capsule synthesis protein
ES968_RS18945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES968_RS18950	COG1609	Transcriptional regulator
ES968_RS18955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_RS18960	COG1869	D-ribose catabolic process
ES968_RS18965	COG1129	ABC transporter
ES968_RS18970	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES968_RS18975	COG1879	ABC-type sugar transport system periplasmic component
ES968_RS18980	COG3103	Sh3 type 3 domain protein
ES968_RS18990	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES968_RS18995	COG3527	Alpha-acetolactate decarboxylase
ES968_RS19000	COG0028	Belongs to the TPP enzyme family
ES968_RS19005	COG0583	DNA-binding transcription factor activity
ES968_RS19010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES968_RS19025	COG5337	Spore coat protein CotH
ES968_RS19035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES968_RS19045	COG0405	Gamma-glutamyltransferase
ES968_RS19050	COG1522	sequence-specific DNA binding
ES968_RS19055	COG2059	Chromate
ES968_RS19060	COG2059	Chromate
ES968_RS19070	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES968_RS19075	COG0583	DNA-binding transcription factor activity
ES968_RS19105	COG5444	nuclease activity
ES968_RS19125	COG3878	Protein conserved in bacteria
ES968_RS19130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_RS19135	COG4464	protein tyrosine phosphatase activity
ES968_RS19140	COG0489	protein tyrosine kinase activity
ES968_RS19145	COG3944	biosynthesis protein
ES968_RS19155	COG4715	Zinc finger, swim domain protein
ES968_RS19160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES968_RS19170	COG0561	phosphatase activity
ES968_RS19175	COG1349	DNA-binding transcription factor activity
ES968_RS19180	COG0629	single-stranded DNA binding
ES968_RS19195	COG3764	Sortase (surface protein transpeptidase)
ES968_RS19205	COG0745	RESPONSE REGULATOR receiver
ES968_RS19205	COG2972	Histidine kinase
ES968_RS19210	COG1970	mechanosensitive ion channel activity
ES968_RS19215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES968_RS19220	COG0457	Tetratricopeptide repeat
ES968_RS19225	COG4786	Flagellar basal body rod
ES968_RS19230	COG4786	Flagellar basal body rod
ES968_RS19235	COG1077	Cell shape determining protein MreB Mrl
ES968_RS19240	COG1609	Transcriptional regulator
ES968_RS19250	COG1846	Transcriptional regulator
ES968_RS19255	COG2814	Major facilitator Superfamily
ES968_RS19265	COG1953	Uracil, thiamine, allantoin
ES968_RS19270	COG0477	Major facilitator Superfamily
ES968_RS19275	COG1335	isochorismatase
ES968_RS19285	COG0004	ammonium transporteR
ES968_RS19290	COG0347	Belongs to the P(II) protein family
ES968_RS19295	COG0671	phosphoesterase, PA-phosphatase related
ES968_RS19305	COG0739	heme binding
ES968_RS19310	COG1247	-acetyltransferase
ES968_RS19320	COG2089	acid synthase
ES968_RS19330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_RS19335	COG0789	Transcriptional regulator
ES968_RS19350	COG1959	2 iron, 2 sulfur cluster binding
ES968_RS19355	COG0804	urea catabolic process
ES968_RS19360	COG0832	Belongs to the urease beta subunit family
ES968_RS19365	COG0831	urea catabolic process
ES968_RS19380	COG3237	CsbD-like
ES968_RS19385	COG1994	Peptidase M50
ES968_RS19390	COG0457	Tetratricopeptide repeat
ES968_RS19395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES968_RS19400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES968_RS19410	COG2304	oxidoreductase activity
ES968_RS19420	COG2304	oxidoreductase activity
ES968_RS19425	COG2385	sporulation resulting in formation of a cellular spore
ES968_RS19430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES968_RS19440	COG4836	Membrane
ES968_RS19450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES968_RS19455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES968_RS19460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES968_RS19465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES968_RS19470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES968_RS19475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES968_RS19485	COG0356	it plays a direct role in the translocation of protons across the membrane
ES968_RS19495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES968_RS19500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES968_RS19505	COG4475	Protein of unknown function (DUF436)
ES968_RS19510	COG0698	ribose 5-phosphate isomerase
ES968_RS19515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES968_RS19520	COG1971	Probably functions as a manganese efflux pump
ES968_RS19525	COG0009	L-threonylcarbamoyladenylate synthase
ES968_RS19530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES968_RS19550	COG2890	protein-(glutamine-N5) methyltransferase activity
ES968_RS19555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES968_RS19560	COG0346	lactoylglutathione lyase activity
ES968_RS19565	COG0789	Transcriptional regulator
ES968_RS19570	COG0679	Auxin Efflux Carrier
ES968_RS19575	COG0281	malic enzyme
ES968_RS19580	COG1435	thymidine kinase activity
ES968_RS19590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES968_RS19600	COG1494	fructose-1,6-bisphosphatase
ES968_RS19605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES968_RS19610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES968_RS19615	COG0191	fructose-bisphosphate aldolase activity
ES968_RS19620	COG2204	response regulator
ES968_RS19625	COG4821	SIS domain
ES968_RS19630	COG0504	CTP synthase activity
ES968_RS19635	COG3343	RNA polymerase activity
ES968_RS19640	COG1960	acyl-CoA dehydrogenase activity
ES968_RS19645	COG0247	lactate metabolic process
ES968_RS19645	COG2181	nitrate reductase activity
ES968_RS19650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_RS19655	COG4294	response to UV
ES968_RS19665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_RS19670	COG1132	(ABC) transporter
ES968_RS19675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_RS19685	COG2181	nitrate reductase activity
ES968_RS19690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES968_RS19695	COG1140	nitrate reductase beta subunit
ES968_RS19700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES968_RS19710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES968_RS19720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES968_RS19725	COG2223	nitrite transmembrane transporter activity
ES968_RS19730	COG0018	arginyl-trna synthetase
ES968_RS19735	COG4506	Protein conserved in bacteria
ES968_RS19750	COG0535	radical SAM domain protein
ES968_RS19760	COG1131	(ABC) transporter
ES968_RS19765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES968_RS19770	COG0612	Peptidase, M16
ES968_RS19775	COG0612	Peptidase, M16
ES968_RS19785	COG3391	amine dehydrogenase activity
ES968_RS19790	COG3391	amine dehydrogenase activity
ES968_RS19800	COG0457	Tetratricopeptide repeat
ES968_RS19815	COG0010	Belongs to the arginase family
ES968_RS19820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES968_RS19825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_RS19840	COG1994	Peptidase M50
ES968_RS19845	COG1942	4-Oxalocrotonate Tautomerase
ES968_RS19850	COG1846	Transcriptional regulator
ES968_RS19855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES968_RS19865	COG0477	Major facilitator Superfamily
ES968_RS19870	COG1959	2 iron, 2 sulfur cluster binding
ES968_RS19875	COG3465	dGTPase activity
ES968_RS19880	COG1078	dGTPase activity
ES968_RS19885	COG4844	belongs to the
ES968_RS19895	COG0697	spore germination
ES968_RS19900	COG0095	Lipoate-protein ligase
ES968_RS19905	COG0583	DNA-binding transcription factor activity
ES968_RS19910	COG0280	phosphate acetyltransferase
ES968_RS19915	COG3253	May function as heme-dependent peroxidase
ES968_RS19925	COG0436	Aminotransferase
ES968_RS19930	COG2814	Major facilitator Superfamily
ES968_RS19935	COG0151	Belongs to the GarS family
ES968_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS19950	COG0077	Prephenate dehydratase
ES968_RS19955	COG2814	Major facilitator Superfamily
ES968_RS19960	COG0833	amino acid
ES968_RS19965	COG4187	Peptidase family M20/M25/M40
ES968_RS19970	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS19975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_RS19985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES968_RS19990	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES968_RS19995	COG1088	dTDP-glucose 4,6-dehydratase activity
ES968_RS20000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES968_RS20005	COG3980	spore coat polysaccharide biosynthesis protein
ES968_RS20010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES968_RS20015	COG2089	acid synthase
ES968_RS20020	COG0456	acetyltransferase
ES968_RS20025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_RS20030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_RS20035	COG0463	Glycosyl transferase, family 2
ES968_RS20045	COG2363	Small membrane protein
ES968_RS20050	COG2233	PERMEase
ES968_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS20065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES968_RS20070	COG1216	Glycosyl transferase, family 2
ES968_RS20085	COG1695	Transcriptional regulator
ES968_RS20090	COG0351	phosphomethylpyrimidine kinase
ES968_RS20100	COG1621	beta-fructofuranosidase activity
ES968_RS20105	COG1263	PTS System
ES968_RS20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS20110	COG2116	formate transmembrane transporter activity
ES968_RS20115	COG3711	transcriptional antiterminator
ES968_RS20125	COG1404	Belongs to the peptidase S8 family
ES968_RS20130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_RS20135	COG0778	Nitroreductase
ES968_RS20145	COG0772	Belongs to the SEDS family
ES968_RS20160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES968_RS20165	COG1845	cytochrome c oxidase, subunit III
ES968_RS20170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES968_RS20175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES968_RS20180	COG2261	transglycosylase associated protein
ES968_RS20185	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES968_RS20190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES968_RS20195	COG2246	polysaccharide biosynthetic process
ES968_RS20200	COG1309	transcriptional regulator
ES968_RS20210	COG3162	membrane
ES968_RS20215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_RS20220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES968_RS20225	COG2837	iron assimilation
ES968_RS20230	COG2822	iron ion transport
ES968_RS20235	COG0672	)-iron permease
ES968_RS20240	COG0352	thiamine-phosphate diphosphorylase activity
ES968_RS20245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES968_RS20250	COG0583	DNA-binding transcription factor activity
ES968_RS20255	COG1380	Effector of murein hydrolase LrgA
ES968_RS20260	COG1346	cytolysis
ES968_RS20265	COG2814	Major facilitator Superfamily
ES968_RS20270	COG4895	conserved protein (DUF2196)
ES968_RS20275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES968_RS20280	COG0346	lactoylglutathione lyase activity
ES968_RS20290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_RS20295	COG1404	Belongs to the peptidase S8 family
ES968_RS20300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_RS20300	COG1263	PTS System
ES968_RS20305	COG3711	transcriptional antiterminator
ES968_RS20310	COG1442	glycosyl transferase family 8
ES968_RS20315	COG5522	Integral membrane protein (intg_mem_TP0381)
ES968_RS20320	COG1846	Transcriptional regulator
ES968_RS20325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES968_RS20330	COG2234	aminopeptidase activity
ES968_RS20335	COG2357	RelA SpoT domain protein
ES968_RS20340	COG1575	Belongs to the MenA family. Type 1 subfamily
ES968_RS20360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_RS20365	COG1696	Membrane protein involved in D-alanine export
ES968_RS20370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES968_RS20375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES968_RS20385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_RS20390	COG1486	melibiose metabolic process
ES968_RS20395	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES968_RS20400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_RS20405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_RS20410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_RS20410	COG3711	transcriptional antiterminator
ES968_RS20420	COG2094	Belongs to the DNA glycosylase MPG family
ES968_RS20425	COG0753	catalase activity
ES968_RS20430	COG2814	Major facilitator Superfamily
ES968_RS20435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_RS20440	COG1131	(ABC) transporter
ES968_RS20460	COG1595	DNA-templated transcription, initiation
ES968_RS20465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES968_RS20475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES968_RS20480	COG4988	ABC transporter
ES968_RS20485	COG1294	oxidase, subunit
ES968_RS20490	COG1271	oxidase subunit
ES968_RS20495	COG3493	citrate carrier protein
ES968_RS20500	COG0501	Belongs to the peptidase M48B family
ES968_RS20510	COG0726	polysaccharide deacetylase
ES968_RS20515	COG3842	ATPase activity
ES968_RS20520	COG2508	Transcriptional regulator
ES968_RS20530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_RS20535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES968_RS20545	COG4585	Histidine kinase
ES968_RS20550	COG2197	response regulator
ES968_RS20555	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES968_RS20565	COG4894	glucomannan catabolic process
ES968_RS20570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_RS20575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_RS20580	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS20585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES968_RS20590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES968_RS20595	COG2610	gluconate transmembrane transporter activity
ES968_RS20600	COG0500	methyltransferase
ES968_RS20605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_RS20620	COG0753	catalase activity
ES968_RS20620	COG0693	protein deglycase activity
ES968_RS20625	COG2851	Citrate transporter
ES968_RS20630	COG2273	Hydrolase Family 16
ES968_RS20635	COG3711	transcriptional antiterminator
ES968_RS20645	COG2270	Major facilitator Superfamily
ES968_RS20650	COG0513	Belongs to the DEAD box helicase family
ES968_RS20655	COG3401	FG-GAP repeat protein
ES968_RS20655	COG2755	lipolytic protein G-D-S-L family
ES968_RS20775	COG0697	spore germination
ES968_RS20790	COG0589	response to stress
ES968_RS20820	COG5444	nuclease activity
ES968_RS20835	COG3507	Belongs to the glycosyl hydrolase 43 family
ES968_RS20850	COG2986	histidine ammonia-lyase
ES968_RS20865	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES968_RS20870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_RS20875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES968_RS20880	COG2390	Transcriptional regulator
ES968_RS20890	COG3192	ethanolamine utilization protein
ES968_RS20895	COG2079	MmgE PrpD family protein
ES968_RS20900	COG1473	amidohydrolase
ES968_RS20905	COG1126	abc transporter atp-binding protein
ES968_RS20910	COG0765	amino acid transport
ES968_RS20915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_RS20920	COG0456	acetyltransferase
ES968_RS20925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_RS20930	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES968_RS20935	COG0561	phosphatase activity
ES968_RS20965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_RS20970	COG5294	Protein conserved in bacteria
ES968_RS20975	COG0577	efflux transmembrane transporter activity
ES968_RS20980	COG1136	(ABC) transporter
ES968_RS20985	COG2205	protein histidine kinase activity
ES968_RS20990	COG0745	RESPONSE REGULATOR receiver
ES968_RS20995	COG0191	fructose-bisphosphate aldolase activity
ES968_RS21000	COG1082	Xylose isomerase domain protein TIM barrel
ES968_RS21005	COG1082	Xylose isomerase domain protein TIM barrel
ES968_RS21010	COG0673	inositol 2-dehydrogenase activity
ES968_RS21015	COG2814	Major facilitator Superfamily
ES968_RS21020	COG1082	Xylose isomerase domain protein TIM barrel
ES968_RS21025	COG3962	Belongs to the TPP enzyme family
ES968_RS21030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_RS21040	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS21045	COG1349	DNA-binding transcription factor activity
ES968_RS21050	COG0667	Aldo Keto reductase
ES968_RS21070	COG0326	Molecular chaperone. Has ATPase activity
ES968_RS21085	COG1309	transcriptional regulator
ES968_RS21090	COG1012	belongs to the aldehyde dehydrogenase family
ES968_RS21095	COG1714	RDD family
ES968_RS21105	COG1714	RDD family
ES968_RS21110	COG2311	Membrane
ES968_RS21115	COG1917	Cupin 2, conserved barrel domain protein
ES968_RS21120	COG1309	transcriptional regulator
ES968_RS21125	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_RS21130	COG1846	Transcriptional regulator
ES968_RS21135	COG1380	Effector of murein hydrolase LrgA
ES968_RS21140	COG1346	cytolysis
ES968_RS21145	COG5039	Polysaccharide pyruvyl transferase
ES968_RS21150	COG1929	Belongs to the glycerate kinase type-1 family
ES968_RS21155	COG1802	Transcriptional regulator
ES968_RS21160	COG1070	Carbohydrate kinase
ES968_RS21165	COG2610	gluconate transmembrane transporter activity
ES968_RS21170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES968_RS21175	COG0450	alkyl hydroperoxide reductase
ES968_RS21180	COG3634	alkyl hydroperoxide reductase activity
ES968_RS21185	COG2723	6-phospho-beta-galactosidase activity
ES968_RS21200	COG2188	Transcriptional regulator
ES968_RS21215	COG1131	(ABC) transporter
ES968_RS21220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES968_RS21235	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_RS21270	COG0210	DNA helicase
ES968_RS21315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES968_RS21350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES968_RS21355	COG0456	acetyltransferase
ES968_RS21360	COG0457	Tetratricopeptide repeat
ES968_RS21370	COG0010	Belongs to the arginase family
ES968_RS21375	COG0833	amino acid
ES968_RS21380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES968_RS21400	COG5658	integral membrane protein
ES968_RS21405	COG0640	Transcriptional regulator
ES968_RS21410	COG3829	transcription factor binding
ES968_RS21425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_RS21430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES968_RS21435	COG4853	Protein conserved in bacteria
ES968_RS21440	COG4863	YycH protein
ES968_RS21445	COG5002	protein histidine kinase activity
ES968_RS21450	COG0745	RESPONSE REGULATOR receiver
ES968_RS21480	COG0346	lactoylglutathione lyase activity
ES968_RS21485	COG0305	Participates in initiation and elongation during chromosome replication
ES968_RS21500	COG3093	addiction module antidote protein HigA
ES968_RS21505	COG2807	transmembrane transport
ES968_RS21510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES968_RS21515	COG0359	binds to the 23S rRNA
ES968_RS21520	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES968_RS21540	COG1733	regulation of RNA biosynthetic process
ES968_RS21545	COG1227	inorganic diphosphatase activity
ES968_RS21565	COG0789	Transcriptional regulator
ES968_RS21565	COG4978	Transcriptional regulator
ES968_RS21575	COG4319	ketosteroid isomerase
ES968_RS21580	COG1357	PFAM Pentapeptide repeats (8 copies)
ES968_RS21595	COG1846	Transcriptional regulator
ES968_RS21600	COG2153	protein acetylation
ES968_RS21605	COG2364	Membrane
ES968_RS21610	COG0456	acetyltransferase
ES968_RS21620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_RS21630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ES968_RS21635	COG1331	Highly conserved protein containing a thioredoxin domain
ES968_RS21640	COG1266	CAAX protease self-immunity
ES968_RS21645	COG2814	Major facilitator Superfamily
ES968_RS21645	COG0477	Major facilitator Superfamily
ES968_RS21650	COG0110	maltose O-acetyltransferase activity
ES968_RS21655	COG0346	lactoylglutathione lyase activity
ES968_RS21660	COG1609	Transcriptional regulator
ES968_RS21665	COG0708	Exodeoxyribonuclease III
ES968_RS21670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES968_RS21675	COG0629	single-stranded DNA binding
ES968_RS21680	COG0360	Binds together with S18 to 16S ribosomal RNA
ES968_RS21685	COG0012	GTP binding
ES968_RS21690	COG0243	molybdopterin cofactor binding
ES968_RS21695	COG4481	Protein conserved in bacteria
ES968_RS21700	COG3949	Membrane
ES968_RS21710	COG1475	DNA binding
ES968_RS21715	COG1192	Involved in chromosome partitioning
ES968_RS21725	COG1475	DNA binding
ES968_RS21730	COG0357	Ribosomal RNA small subunit methyltransferase G
ES968_RS21735	COG0445	tRNA wobble uridine modification
ES968_RS21740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES968_RS21745	COG1847	R3H domain protein
ES968_RS21750	COG0706	membrane insertase activity
ES968_RS21755	COG0594	ribonuclease P activity
ES968_RS21775	COG1073	alpha beta
ES968_RS21780	COG4191	Histidine kinase
ES968_RS21790	COG1476	TRANSCRIPTIONal
ES968_RS21875	COG0741	lytic transglycosylase activity
ES968_RS21875	COG0791	NLP P60 protein
ES968_RS21910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES968_RS21940	COG1793	dna ligase
ES968_RS22100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES968_RS22115	COG4974	Belongs to the 'phage' integrase family
ES968_RS22125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_RS22170	COG0582	viral genome integration into host DNA