locus-tag	class	description
PF977_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PF977_RS00015	COG0594	ribonuclease P activity
PF977_RS00020	COG0706	membrane insertase activity
PF977_RS00025	COG1847	R3H domain protein
PF977_RS00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PF977_RS00035	COG0445	tRNA wobble uridine modification
PF977_RS00040	COG0357	Ribosomal RNA small subunit methyltransferase G
PF977_RS00045	COG1475	DNA binding
PF977_RS00055	COG1192	Involved in chromosome partitioning
PF977_RS00060	COG1475	DNA binding
PF977_RS00070	COG3949	Membrane
PF977_RS00075	COG4481	Protein conserved in bacteria
PF977_RS00080	COG0243	molybdopterin cofactor binding
PF977_RS00085	COG0012	GTP binding
PF977_RS00090	COG0360	Binds together with S18 to 16S ribosomal RNA
PF977_RS00095	COG0629	single-stranded DNA binding
PF977_RS00100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PF977_RS00105	COG0708	Exodeoxyribonuclease III
PF977_RS00110	COG1609	Transcriptional regulator
PF977_RS00115	COG0346	lactoylglutathione lyase activity
PF977_RS00120	COG0110	maltose O-acetyltransferase activity
PF977_RS00125	COG0477	Major facilitator Superfamily
PF977_RS00125	COG2814	Major facilitator Superfamily
PF977_RS00130	COG1266	CAAX protease self-immunity
PF977_RS00135	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_RS00140	COG0697	spore germination
PF977_RS00145	COG0789	Transcriptional regulator
PF977_RS00150	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_RS00155	COG2814	Major facilitator Superfamily
PF977_RS00165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_RS00170	COG2315	Protein conserved in bacteria
PF977_RS00175	COG0456	acetyltransferase
PF977_RS00180	COG2364	Membrane
PF977_RS00185	COG2153	protein acetylation
PF977_RS00190	COG1846	Transcriptional regulator
PF977_RS00195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS00210	COG2153	protein acetylation
PF977_RS00215	COG0583	DNA-binding transcription factor activity
PF977_RS00220	COG2814	Major facilitator Superfamily
PF977_RS00225	COG1357	PFAM Pentapeptide repeats (8 copies)
PF977_RS00230	COG4319	ketosteroid isomerase
PF977_RS00240	COG0789	Transcriptional regulator
PF977_RS00240	COG4978	Transcriptional regulator
PF977_RS00245	COG2271	Major facilitator Superfamily
PF977_RS00260	COG1227	inorganic diphosphatase activity
PF977_RS00265	COG1733	regulation of RNA biosynthetic process
PF977_RS00270	COG5577	PFAM Coat F domain
PF977_RS00280	COG4241	membrane
PF977_RS00285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PF977_RS00290	COG0359	binds to the 23S rRNA
PF977_RS00295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF977_RS00300	COG2807	transmembrane transport
PF977_RS00305	COG3093	addiction module antidote protein HigA
PF977_RS00320	COG0305	Participates in initiation and elongation during chromosome replication
PF977_RS00325	COG0346	lactoylglutathione lyase activity
PF977_RS00355	COG0745	RESPONSE REGULATOR receiver
PF977_RS00360	COG5002	protein histidine kinase activity
PF977_RS00365	COG4863	YycH protein
PF977_RS00370	COG4853	Protein conserved in bacteria
PF977_RS00375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF977_RS00380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_RS00395	COG3829	transcription factor binding
PF977_RS00400	COG0640	Transcriptional regulator
PF977_RS00405	COG5658	integral membrane protein
PF977_RS00425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF977_RS00430	COG0833	amino acid
PF977_RS00435	COG0010	Belongs to the arginase family
PF977_RS00445	COG0457	Tetratricopeptide repeat
PF977_RS00450	COG0456	acetyltransferase
PF977_RS00455	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PF977_RS00475	COG1063	alcohol dehydrogenase
PF977_RS00490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PF977_RS00505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
PF977_RS00520	COG3634	alkyl hydroperoxide reductase activity
PF977_RS00525	COG0450	alkyl hydroperoxide reductase
PF977_RS00530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF977_RS00535	COG2610	gluconate transmembrane transporter activity
PF977_RS00540	COG1070	Carbohydrate kinase
PF977_RS00545	COG1802	Transcriptional regulator
PF977_RS00550	COG1929	Belongs to the glycerate kinase type-1 family
PF977_RS00555	COG5039	Polysaccharide pyruvyl transferase
PF977_RS00560	COG1346	cytolysis
PF977_RS00565	COG1380	Effector of murein hydrolase LrgA
PF977_RS00570	COG1846	Transcriptional regulator
PF977_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS00580	COG1309	transcriptional regulator
PF977_RS00585	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS00590	COG2311	Membrane
PF977_RS00595	COG1714	RDD family
PF977_RS00605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF977_RS00610	COG1714	RDD family
PF977_RS00615	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS00620	COG1309	transcriptional regulator
PF977_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS00635	COG0326	Molecular chaperone. Has ATPase activity
PF977_RS00640	COG2814	Major facilitator Superfamily
PF977_RS00655	COG0667	Aldo Keto reductase
PF977_RS00660	COG1349	DNA-binding transcription factor activity
PF977_RS00665	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS00675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_RS00680	COG3962	Belongs to the TPP enzyme family
PF977_RS00685	COG1082	Xylose isomerase domain protein TIM barrel
PF977_RS00690	COG2814	Major facilitator Superfamily
PF977_RS00695	COG0673	inositol 2-dehydrogenase activity
PF977_RS00700	COG1082	Xylose isomerase domain protein TIM barrel
PF977_RS00705	COG1082	Xylose isomerase domain protein TIM barrel
PF977_RS00710	COG0191	fructose-bisphosphate aldolase activity
PF977_RS00715	COG0745	RESPONSE REGULATOR receiver
PF977_RS00720	COG2205	protein histidine kinase activity
PF977_RS00725	COG1136	(ABC) transporter
PF977_RS00730	COG0577	efflux transmembrane transporter activity
PF977_RS00735	COG5294	Protein conserved in bacteria
PF977_RS00740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS00770	COG0561	phosphatase activity
PF977_RS00775	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PF977_RS00780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS00785	COG0456	acetyltransferase
PF977_RS00790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS00795	COG0765	amino acid transport
PF977_RS00800	COG1126	abc transporter atp-binding protein
PF977_RS00805	COG1473	amidohydrolase
PF977_RS00810	COG2079	MmgE PrpD family protein
PF977_RS00815	COG3192	ethanolamine utilization protein
PF977_RS00825	COG2390	Transcriptional regulator
PF977_RS00830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PF977_RS00835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_RS00840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PF977_RS00845	COG0833	amino acid
PF977_RS00850	COG0010	Belongs to the arginase family
PF977_RS00855	COG1228	amidohydrolase
PF977_RS00860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PF977_RS00865	COG2986	histidine ammonia-lyase
PF977_RS00880	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_RS00930	COG1263	PTS System
PF977_RS00930	COG2190	(PTS) system
PF977_RS00930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS00935	COG2723	6-phospho-beta-galactosidase activity
PF977_RS00940	COG0589	response to stress
PF977_RS00945	COG0697	spore germination
PF977_RS00950	COG3209	COG3209 Rhs family protein
PF977_RS01010	COG2755	lipolytic protein G-D-S-L family
PF977_RS01010	COG3401	FG-GAP repeat protein
PF977_RS01015	COG0513	Belongs to the DEAD box helicase family
PF977_RS01020	COG2270	Major facilitator Superfamily
PF977_RS01030	COG3711	transcriptional antiterminator
PF977_RS01035	COG2273	Hydrolase Family 16
PF977_RS01040	COG2851	Citrate transporter
PF977_RS01045	COG0753	catalase activity
PF977_RS01045	COG0693	protein deglycase activity
PF977_RS01060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_RS01065	COG0500	methyltransferase
PF977_RS01070	COG2610	gluconate transmembrane transporter activity
PF977_RS01075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF977_RS01080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF977_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS01090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_RS01095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_RS01100	COG4894	glucomannan catabolic process
PF977_RS01115	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF977_RS01120	COG2197	response regulator
PF977_RS01125	COG4585	Histidine kinase
PF977_RS01135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF977_RS01145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS01155	COG2508	Transcriptional regulator
PF977_RS01160	COG3842	ATPase activity
PF977_RS01165	COG0726	polysaccharide deacetylase
PF977_RS01175	COG0501	Belongs to the peptidase M48B family
PF977_RS01180	COG3493	citrate carrier protein
PF977_RS01185	COG1271	oxidase subunit
PF977_RS01190	COG1294	oxidase, subunit
PF977_RS01195	COG4988	ABC transporter
PF977_RS01200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PF977_RS01205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF977_RS01210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF977_RS01215	COG1595	DNA-templated transcription, initiation
PF977_RS01235	COG1131	(ABC) transporter
PF977_RS01240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_RS01245	COG2814	Major facilitator Superfamily
PF977_RS01250	COG0753	catalase activity
PF977_RS01255	COG2094	Belongs to the DNA glycosylase MPG family
PF977_RS01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS01265	COG3711	transcriptional antiterminator
PF977_RS01270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_RS01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_RS01280	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF977_RS01285	COG1486	melibiose metabolic process
PF977_RS01290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_RS01295	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PF977_RS01300	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PF977_RS01305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_RS01310	COG1696	Membrane protein involved in D-alanine export
PF977_RS01315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS01330	COG1575	Belongs to the MenA family. Type 1 subfamily
PF977_RS01335	COG2357	RelA SpoT domain protein
PF977_RS01340	COG2814	Major facilitator Superfamily
PF977_RS01355	COG2234	aminopeptidase activity
PF977_RS01360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF977_RS01365	COG1846	Transcriptional regulator
PF977_RS01370	COG5522	Integral membrane protein (intg_mem_TP0381)
PF977_RS01375	COG1442	glycosyl transferase family 8
PF977_RS01380	COG3711	transcriptional antiterminator
PF977_RS01385	COG1263	PTS System
PF977_RS01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS01390	COG1404	Belongs to the peptidase S8 family
PF977_RS01410	COG0346	lactoylglutathione lyase activity
PF977_RS01415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF977_RS01420	COG4895	conserved protein (DUF2196)
PF977_RS01425	COG2814	Major facilitator Superfamily
PF977_RS01430	COG1346	cytolysis
PF977_RS01435	COG1380	Effector of murein hydrolase LrgA
PF977_RS01440	COG0583	DNA-binding transcription factor activity
PF977_RS01445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PF977_RS01450	COG0352	thiamine-phosphate diphosphorylase activity
PF977_RS01455	COG0672	)-iron permease
PF977_RS01460	COG2822	iron ion transport
PF977_RS01465	COG2837	iron assimilation
PF977_RS01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF977_RS01475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_RS01480	COG3162	membrane
PF977_RS01490	COG1309	transcriptional regulator
PF977_RS01495	COG2246	polysaccharide biosynthetic process
PF977_RS01500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PF977_RS01505	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PF977_RS01510	COG2261	transglycosylase associated protein
PF977_RS01515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF977_RS01520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF977_RS01525	COG1845	cytochrome c oxidase, subunit III
PF977_RS01530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF977_RS01540	COG0772	Belongs to the SEDS family
PF977_RS01545	COG0778	Nitroreductase
PF977_RS01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS01555	COG1404	Belongs to the peptidase S8 family
PF977_RS01565	COG3711	transcriptional antiterminator
PF977_RS01570	COG2116	formate transmembrane transporter activity
PF977_RS01575	COG1263	PTS System
PF977_RS01575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS01580	COG1621	beta-fructofuranosidase activity
PF977_RS01590	COG0351	phosphomethylpyrimidine kinase
PF977_RS01595	COG1216	Glycosyl transferase, family 2
PF977_RS01600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PF977_RS01605	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS01615	COG2233	PERMEase
PF977_RS01620	COG2363	Small membrane protein
PF977_RS01630	COG0463	Glycosyl transferase, family 2
PF977_RS01635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_RS01640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_RS01645	COG0456	acetyltransferase
PF977_RS01650	COG2089	acid synthase
PF977_RS01655	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PF977_RS01660	COG3980	spore coat polysaccharide biosynthesis protein
PF977_RS01665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PF977_RS01670	COG1088	dTDP-glucose 4,6-dehydratase activity
PF977_RS01675	COG1091	dTDP-4-dehydrorhamnose reductase activity
PF977_RS01680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PF977_RS01690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_RS01695	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS01700	COG4187	Peptidase family M20/M25/M40
PF977_RS01705	COG0833	amino acid
PF977_RS01710	COG2814	Major facilitator Superfamily
PF977_RS01715	COG0077	Prephenate dehydratase
PF977_RS01720	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS01730	COG0151	Belongs to the GarS family
PF977_RS01735	COG2814	Major facilitator Superfamily
PF977_RS01740	COG0436	Aminotransferase
PF977_RS01745	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS01750	COG3253	May function as heme-dependent peroxidase
PF977_RS01755	COG0280	phosphate acetyltransferase
PF977_RS01760	COG0583	DNA-binding transcription factor activity
PF977_RS01765	COG0095	Lipoate-protein ligase
PF977_RS01770	COG0697	spore germination
PF977_RS01780	COG4844	belongs to the
PF977_RS01785	COG1078	dGTPase activity
PF977_RS01790	COG3465	dGTPase activity
PF977_RS01795	COG1959	2 iron, 2 sulfur cluster binding
PF977_RS01800	COG0477	Major facilitator Superfamily
PF977_RS01805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF977_RS01810	COG1846	Transcriptional regulator
PF977_RS01815	COG1942	4-Oxalocrotonate Tautomerase
PF977_RS01820	COG1994	Peptidase M50
PF977_RS01830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_RS01835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PF977_RS01840	COG0010	Belongs to the arginase family
PF977_RS01850	COG1131	(ABC) transporter
PF977_RS01880	COG0457	Tetratricopeptide repeat
PF977_RS01885	COG3391	amine dehydrogenase activity
PF977_RS01890	COG3391	amine dehydrogenase activity
PF977_RS01900	COG0612	Peptidase, M16
PF977_RS01905	COG0612	Peptidase, M16
PF977_RS01910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF977_RS01915	COG1131	(ABC) transporter
PF977_RS01925	COG0535	radical SAM domain protein
PF977_RS01940	COG4506	Protein conserved in bacteria
PF977_RS01945	COG0018	arginyl-trna synthetase
PF977_RS01950	COG2223	nitrite transmembrane transporter activity
PF977_RS01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF977_RS01965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF977_RS01970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PF977_RS01975	COG1140	nitrate reductase beta subunit
PF977_RS01980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
PF977_RS01985	COG2181	nitrate reductase activity
PF977_RS01995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_RS02000	COG1132	(ABC) transporter
PF977_RS02015	COG4294	response to UV
PF977_RS02020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_RS02025	COG2181	nitrate reductase activity
PF977_RS02025	COG0247	lactate metabolic process
PF977_RS02030	COG1960	acyl-CoA dehydrogenase activity
PF977_RS02035	COG3343	RNA polymerase activity
PF977_RS02040	COG0504	CTP synthase activity
PF977_RS02045	COG4821	SIS domain
PF977_RS02050	COG2204	response regulator
PF977_RS02055	COG0191	fructose-bisphosphate aldolase activity
PF977_RS02060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF977_RS02065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF977_RS02070	COG1494	fructose-1,6-bisphosphatase
PF977_RS02080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PF977_RS02090	COG1435	thymidine kinase activity
PF977_RS02095	COG0281	malic enzyme
PF977_RS02100	COG0679	Auxin Efflux Carrier
PF977_RS02105	COG0789	Transcriptional regulator
PF977_RS02110	COG0346	lactoylglutathione lyase activity
PF977_RS02115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PF977_RS02120	COG2890	protein-(glutamine-N5) methyltransferase activity
PF977_RS02140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PF977_RS02145	COG0009	L-threonylcarbamoyladenylate synthase
PF977_RS02150	COG1971	Probably functions as a manganese efflux pump
PF977_RS02155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_RS02160	COG0698	ribose 5-phosphate isomerase
PF977_RS02165	COG4475	Protein of unknown function (DUF436)
PF977_RS02170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PF977_RS02175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PF977_RS02185	COG0356	it plays a direct role in the translocation of protons across the membrane
PF977_RS02195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PF977_RS02200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PF977_RS02205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PF977_RS02210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PF977_RS02215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PF977_RS02220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PF977_RS02230	COG4836	Membrane
PF977_RS02240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF977_RS02245	COG2385	sporulation resulting in formation of a cellular spore
PF977_RS02250	COG2304	oxidoreductase activity
PF977_RS02260	COG2304	oxidoreductase activity
PF977_RS02270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF977_RS02275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF977_RS02280	COG0457	Tetratricopeptide repeat
PF977_RS02285	COG1994	Peptidase M50
PF977_RS02290	COG3237	CsbD-like
PF977_RS02305	COG0831	urea catabolic process
PF977_RS02310	COG0832	Belongs to the urease beta subunit family
PF977_RS02315	COG0804	urea catabolic process
PF977_RS02320	COG1959	2 iron, 2 sulfur cluster binding
PF977_RS02325	COG2910	NAD(P)H-binding
PF977_RS02335	COG0789	Transcriptional regulator
PF977_RS02340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_RS02360	COG1247	-acetyltransferase
PF977_RS02365	COG0739	heme binding
PF977_RS02375	COG0671	phosphoesterase, PA-phosphatase related
PF977_RS02380	COG0347	Belongs to the P(II) protein family
PF977_RS02385	COG0004	ammonium transporteR
PF977_RS02395	COG1335	isochorismatase
PF977_RS02400	COG0477	Major facilitator Superfamily
PF977_RS02405	COG1953	Uracil, thiamine, allantoin
PF977_RS02410	COG3420	alginic acid biosynthetic process
PF977_RS02415	COG2814	Major facilitator Superfamily
PF977_RS02420	COG1846	Transcriptional regulator
PF977_RS02430	COG1609	Transcriptional regulator
PF977_RS02435	COG1077	Cell shape determining protein MreB Mrl
PF977_RS02440	COG4786	Flagellar basal body rod
PF977_RS02445	COG4786	Flagellar basal body rod
PF977_RS02450	COG0457	Tetratricopeptide repeat
PF977_RS02455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF977_RS02460	COG1970	mechanosensitive ion channel activity
PF977_RS02465	COG2972	Histidine kinase
PF977_RS02465	COG0745	RESPONSE REGULATOR receiver
PF977_RS02485	COG0629	single-stranded DNA binding
PF977_RS02490	COG1349	DNA-binding transcription factor activity
PF977_RS02495	COG0561	phosphatase activity
PF977_RS02500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF977_RS02505	COG4715	Zinc finger, swim domain protein
PF977_RS02515	COG3944	biosynthesis protein
PF977_RS02520	COG0489	protein tyrosine kinase activity
PF977_RS02525	COG4464	protein tyrosine phosphatase activity
PF977_RS02530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_RS02535	COG3878	Protein conserved in bacteria
PF977_RS02555	COG5444	nuclease activity
PF977_RS02570	COG0583	DNA-binding transcription factor activity
PF977_RS02575	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF977_RS02585	COG2059	Chromate
PF977_RS02590	COG2059	Chromate
PF977_RS02595	COG1522	sequence-specific DNA binding
PF977_RS02600	COG0405	Gamma-glutamyltransferase
PF977_RS02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF977_RS02620	COG5337	Spore coat protein CotH
PF977_RS02635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF977_RS02640	COG0583	DNA-binding transcription factor activity
PF977_RS02645	COG0028	Belongs to the TPP enzyme family
PF977_RS02650	COG3527	Alpha-acetolactate decarboxylase
PF977_RS02655	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF977_RS02665	COG3103	Sh3 type 3 domain protein
PF977_RS02670	COG1879	ABC-type sugar transport system periplasmic component
PF977_RS02675	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF977_RS02680	COG1129	ABC transporter
PF977_RS02685	COG1869	D-ribose catabolic process
PF977_RS02690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_RS02695	COG1609	Transcriptional regulator
PF977_RS02700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF977_RS02710	COG2843	Capsule synthesis protein
PF977_RS02720	COG0791	NLP P60 protein
PF977_RS02725	COG0561	phosphatase activity
PF977_RS02730	COG1316	TRANSCRIPTIONal
PF977_RS02735	COG2814	Major facilitator Superfamily
PF977_RS02745	COG0814	amino acid
PF977_RS02750	COG0697	spore germination
PF977_RS02755	COG1482	cell wall glycoprotein biosynthetic process
PF977_RS02760	COG4193	domain, Protein
PF977_RS02770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_RS02775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PF977_RS02780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PF977_RS02785	COG0438	transferase activity, transferring glycosyl groups
PF977_RS02790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_RS02795	COG1682	transport, permease protein
PF977_RS02800	COG1134	teichoic acid transport
PF977_RS02805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_RS02810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PF977_RS02815	COG1316	TRANSCRIPTIONal
PF977_RS02825	COG2385	sporulation resulting in formation of a cellular spore
PF977_RS02825	COG2247	cell wall binding repeat
PF977_RS02830	COG2247	cell wall binding repeat
PF977_RS02830	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS02840	COG2244	polysaccharide biosynthetic process
PF977_RS02845	COG0297	glycogen (starch) synthase activity
PF977_RS02845	COG0438	transferase activity, transferring glycosyl groups
PF977_RS02850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_RS02855	COG3307	-O-antigen
PF977_RS02860	COG3206	protein involved in exopolysaccharide biosynthesis
PF977_RS02865	COG1215	transferase activity, transferring glycosyl groups
PF977_RS02870	COG0438	transferase activity, transferring glycosyl groups
PF977_RS02875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF977_RS02880	COG1316	TRANSCRIPTIONal
PF977_RS02885	COG1739	Uncharacterized protein family UPF0029
PF977_RS02890	COG4585	Histidine kinase
PF977_RS02895	COG2197	response regulator
PF977_RS02900	COG1307	EDD domain protein, DegV family
PF977_RS02905	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PF977_RS02915	COG1040	competence protein
PF977_RS02925	COG2747	anti-sigma28 factor FlgM
PF977_RS02930	COG3418	PFAM FlgN family protein
PF977_RS02935	COG4786	Flagellar basal body rod
PF977_RS02935	COG1256	bacterial-type flagellum assembly
PF977_RS02940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF977_RS02950	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PF977_RS02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PF977_RS02960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF977_RS02965	COG1334	flagellar protein FlaG
PF977_RS02970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PF977_RS02975	COG1516	flagellar protein fliS
PF977_RS02990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PF977_RS02995	COG0653	protein targeting
PF977_RS03005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS03010	COG2010	Cytochrome c
PF977_RS03015	COG2884	Cell division ATP-binding protein ftsE
PF977_RS03020	COG2177	Part of the ABC transporter FtsEX involved in
PF977_RS03025	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS03025	COG0793	Belongs to the peptidase S41A family
PF977_RS03035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_RS03040	COG2814	Major facilitator Superfamily
PF977_RS03045	COG1309	transcriptional regulator
PF977_RS03050	COG0574	Belongs to the PEP-utilizing enzyme family
PF977_RS03050	COG3848	Pyruvate phosphate dikinase
PF977_RS03055	COG4897	Protein conserved in bacteria
PF977_RS03060	COG0556	nucleotide-excision repair
PF977_RS03065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF977_RS03085	COG3595	metallopeptidase activity
PF977_RS03090	COG1983	PspC domain protein
PF977_RS03095	COG1950	PFAM Membrane protein of
PF977_RS03100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF977_RS03105	COG2188	Transcriptional regulator
PF977_RS03110	COG0363	glucosamine-6-phosphate deaminase activity
PF977_RS03115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PF977_RS03120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PF977_RS03125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PF977_RS03130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PF977_RS03135	COG0546	phosphoglycolate phosphatase activity
PF977_RS03140	COG0110	maltose O-acetyltransferase activity
PF977_RS03145	COG5297	Belongs to the glycosyl hydrolase family 6
PF977_RS03150	COG4990	cell redox homeostasis
PF977_RS03155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PF977_RS03160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF977_RS03165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF977_RS03170	COG0131	Imidazoleglycerol-phosphate dehydratase
PF977_RS03175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF977_RS03180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PF977_RS03185	COG0107	imidazoleglycerol-phosphate synthase activity
PF977_RS03190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF977_RS03190	COG0140	phosphoribosyl-ATP diphosphatase activity
PF977_RS03210	COG1132	(ABC) transporter
PF977_RS03215	COG0457	Tetratricopeptide repeat
PF977_RS03220	COG3883	PFAM NLP P60 protein
PF977_RS03220	COG0791	NLP P60 protein
PF977_RS03225	COG0492	ferredoxin-NADP+ reductase activity
PF977_RS03230	COG1051	belongs to the nudix hydrolase family
PF977_RS03235	COG1660	Displays ATPase and GTPase activities
PF977_RS03240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PF977_RS03245	COG1481	regulation of sporulation
PF977_RS03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS03255	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PF977_RS03265	COG0745	RESPONSE REGULATOR receiver
PF977_RS03270	COG5002	protein histidine kinase activity
PF977_RS03275	COG1136	(ABC) transporter
PF977_RS03280	COG0577	efflux transmembrane transporter activity
PF977_RS03285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF977_RS03290	COG0288	reversible hydration of carbon dioxide
PF977_RS03295	COG0659	secondary active sulfate transmembrane transporter activity
PF977_RS03300	COG1694	Mazg nucleotide pyrophosphohydrolase
PF977_RS03305	COG1611	Belongs to the LOG family
PF977_RS03310	COG1609	Transcriptional regulator
PF977_RS03315	COG0366	Alpha amylase catalytic
PF977_RS03320	COG2182	Extracellular solute-binding protein
PF977_RS03325	COG1175	transmembrane transport
PF977_RS03330	COG3833	ABC-type maltose transport systems, permease component
PF977_RS03335	COG5521	maltodextrose utilization protein MalA
PF977_RS03340	COG1554	hydrolase, family 65, central catalytic
PF977_RS03345	COG0366	Alpha amylase catalytic
PF977_RS03350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF977_RS03355	COG0740	serine-type endopeptidase activity
PF977_RS03365	COG3621	Patatin-like phospholipase
PF977_RS03370	COG0277	FAD linked oxidase domain protein
PF977_RS03380	COG2076	Multidrug Resistance protein
PF977_RS03385	COG2076	Multidrug Resistance protein
PF977_RS03390	COG1309	transcriptional regulator
PF977_RS03395	COG0531	amino acid
PF977_RS03400	COG1621	beta-fructofuranosidase activity
PF977_RS03405	COG1621	beta-fructofuranosidase activity
PF977_RS03410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_RS03425	COG3479	Phenolic acid decarboxylase
PF977_RS03435	COG2272	Belongs to the type-B carboxylesterase lipase family
PF977_RS03440	COG1396	sequence-specific DNA binding
PF977_RS03445	COG3944	biosynthesis protein
PF977_RS03450	COG0489	protein tyrosine kinase activity
PF977_RS03455	COG1086	Polysaccharide biosynthesis protein
PF977_RS03460	COG0438	transferase activity, transferring glycosyl groups
PF977_RS03465	COG1215	transferase activity, transferring glycosyl groups
PF977_RS03470	COG0438	transferase activity, transferring glycosyl groups
PF977_RS03480	COG1216	Glycosyl transferase, family 2
PF977_RS03485	COG5039	Polysaccharide pyruvyl transferase
PF977_RS03490	COG1216	Glycosyl transferase, family 2
PF977_RS03495	COG2244	polysaccharide biosynthetic process
PF977_RS03500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF977_RS03505	COG0110	maltose O-acetyltransferase activity
PF977_RS03510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_RS03515	COG5039	Polysaccharide pyruvyl transferase
PF977_RS03525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PF977_RS03530	COG1620	l-lactate permease
PF977_RS03535	COG2186	Transcriptional regulator
PF977_RS03540	COG1609	Transcriptional regulator
PF977_RS03545	COG2182	Extracellular solute-binding protein
PF977_RS03550	COG1175	transmembrane transport
PF977_RS03555	COG3833	ABC-type maltose transport systems, permease component
PF977_RS03560	COG1874	Beta-galactosidase
PF977_RS03565	COG3867	Arabinogalactan endo-beta-1,4-galactanase
PF977_RS03570	COG2208	phosphoserine phosphatase activity
PF977_RS03575	COG0596	Alpha beta hydrolase
PF977_RS03580	COG1131	(ABC) transporter
PF977_RS03585	COG0842	Transport permease protein
PF977_RS03590	COG4585	Histidine kinase
PF977_RS03595	COG2197	response regulator
PF977_RS03600	COG0247	lactate metabolic process
PF977_RS03605	COG1139	Iron-sulfur cluster binding protein
PF977_RS03610	COG1556	Lactate utilization protein
PF977_RS03615	COG3858	chitin binding
PF977_RS03620	COG1113	amino acid transport
PF977_RS03625	COG0697	spore germination
PF977_RS03630	COG0583	DNA-binding transcription factor activity
PF977_RS03635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS03640	COG1609	Transcriptional regulator
PF977_RS03645	COG2814	Major facilitator Superfamily
PF977_RS03650	COG2390	Transcriptional regulator
PF977_RS03655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF977_RS03660	COG0126	phosphoglycerate kinase activity
PF977_RS03665	COG0149	triose-phosphate isomerase activity
PF977_RS03670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF977_RS03675	COG0148	phosphopyruvate hydratase activity
PF977_RS03680	COG2234	aminopeptidase activity
PF977_RS03690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_RS03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS03715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_RS03730	COG0456	acetyltransferase
PF977_RS03735	COG4640	response to antibiotic
PF977_RS03740	COG3064	Membrane
PF977_RS03750	COG2095	MarC family integral membrane protein
PF977_RS03755	COG1510	regulation of RNA biosynthetic process
PF977_RS03760	COG1125	glycine betaine transport
PF977_RS03760	COG0517	IMP dehydrogenase activity
PF977_RS03765	COG1174	glycine betaine transport
PF977_RS03770	COG1732	Glycine betaine
PF977_RS03775	COG1174	glycine betaine transport
PF977_RS03780	COG1510	regulation of RNA biosynthetic process
PF977_RS03785	COG1125	glycine betaine transport
PF977_RS03785	COG0517	IMP dehydrogenase activity
PF977_RS03790	COG1174	glycine betaine transport
PF977_RS03795	COG1732	Glycine betaine
PF977_RS03800	COG1174	glycine betaine transport
PF977_RS03805	COG0840	transmembrane signaling receptor activity
PF977_RS03810	COG1733	regulation of RNA biosynthetic process
PF977_RS03815	COG1396	sequence-specific DNA binding
PF977_RS03820	COG1396	sequence-specific DNA binding
PF977_RS03825	COG1476	TRANSCRIPTIONal
PF977_RS03830	COG0596	Alpha beta hydrolase
PF977_RS03835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF977_RS03840	COG1647	Serine aminopeptidase, S33
PF977_RS03845	COG0557	exoribonuclease II activity
PF977_RS03850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PF977_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS03865	COG1309	transcriptional regulator
PF977_RS03870	COG2076	Multidrug Resistance protein
PF977_RS03880	COG1289	transmembrane transporter activity
PF977_RS03885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF977_RS03890	COG0673	inositol 2-dehydrogenase activity
PF977_RS03895	COG1937	Protein conserved in bacteria
PF977_RS03900	COG2608	mercury ion transmembrane transporter activity
PF977_RS03905	COG2217	Heavy metal translocating P-type atpase
PF977_RS03910	COG2217	Heavy metal translocating P-type atpase
PF977_RS03915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF977_RS03920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF977_RS03925	COG2860	membrane
PF977_RS03930	COG3973	AAA domain
PF977_RS03935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_RS03940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_RS03945	COG0025	NhaP-type Na H and K H
PF977_RS03955	COG0656	L-ascorbic acid biosynthetic process
PF977_RS03960	COG4149	molybdate abc transporter
PF977_RS03965	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF977_RS03970	COG1910	domain protein
PF977_RS03975	COG1368	sulfuric ester hydrolase activity
PF977_RS03980	COG1988	membrane-bound metal-dependent
PF977_RS03990	COG0531	amino acid
PF977_RS03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS04000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS04010	COG1120	ATPase activity
PF977_RS04015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF977_RS04020	COG1136	(ABC) transporter
PF977_RS04025	COG0577	efflux transmembrane transporter activity
PF977_RS04035	COG2140	Oxalate decarboxylase
PF977_RS04045	COG1191	sigma factor activity
PF977_RS04055	COG0745	RESPONSE REGULATOR receiver
PF977_RS04060	COG2205	protein histidine kinase activity
PF977_RS04065	COG3386	PFAM SMP-30 Gluconolaconase
PF977_RS04070	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS04075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS04085	COG1120	ATPase activity
PF977_RS04090	COG2096	Adenosyltransferase
PF977_RS04095	COG2814	Major facilitator Superfamily
PF977_RS04100	COG4758	membrane
PF977_RS04105	COG1842	Phage shock protein A
PF977_RS04110	COG3595	metallopeptidase activity
PF977_RS04115	COG4758	membrane
PF977_RS04120	COG4585	Histidine kinase
PF977_RS04125	COG2197	response regulator
PF977_RS04135	COG0814	amino acid
PF977_RS04140	COG0697	spore germination
PF977_RS04150	COG0114	fumarate hydratase activity
PF977_RS04155	COG1309	transcriptional regulator
PF977_RS04165	COG2770	Histidine kinase
PF977_RS04165	COG2205	protein histidine kinase activity
PF977_RS04170	COG0745	RESPONSE REGULATOR receiver
PF977_RS04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_RS04180	COG0783	Belongs to the Dps family
PF977_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS04200	COG1120	ATPase activity
PF977_RS04210	COG0583	DNA-binding transcription factor activity
PF977_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS04220	COG1942	4-Oxalocrotonate Tautomerase
PF977_RS04225	COG0477	Major facilitator Superfamily
PF977_RS04230	COG1846	Transcriptional regulator
PF977_RS04235	COG5577	PFAM Coat F domain
PF977_RS04245	COG0506	proline dehydrogenase activity
PF977_RS04255	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF977_RS04255	COG1024	Enoyl-CoA hydratase
PF977_RS04260	COG0183	Belongs to the thiolase family
PF977_RS04265	COG1960	acyl-CoA dehydrogenase activity
PF977_RS04270	COG1393	Belongs to the ArsC family
PF977_RS04275	COG0509	glycine decarboxylation via glycine cleavage system
PF977_RS04285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF977_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS04300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF977_RS04305	COG2011	ABC-type metal ion transport system permease component
PF977_RS04310	COG1464	Belongs to the NlpA lipoprotein family
PF977_RS04315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF977_RS04325	COG0396	ATPase activity
PF977_RS04330	COG0719	Fe-S assembly protein
PF977_RS04335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF977_RS04340	COG0822	iron-sulfur transferase activity
PF977_RS04345	COG0719	Fe-S assembly protein
PF977_RS04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_RS04365	COG0322	excinuclease ABC activity
PF977_RS04370	COG2222	sugar isomerase
PF977_RS04375	COG1653	transport
PF977_RS04380	COG1175	transmembrane transport
PF977_RS04385	COG0395	ABC-type sugar transport system, permease component
PF977_RS04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_RS04395	COG2188	Transcriptional regulator
PF977_RS04400	COG3842	ATPase activity
PF977_RS04405	COG2356	endonuclease I
PF977_RS04415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_RS04420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF977_RS04425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PF977_RS04430	COG2068	MobA-Related Protein
PF977_RS04435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PF977_RS04440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF977_RS04445	COG2080	2 iron, 2 sulfur cluster binding
PF977_RS04455	COG2351	hydroxyisourate hydrolase activity
PF977_RS04460	COG3648	Uricase
PF977_RS04460	COG3195	allantoin biosynthetic process
PF977_RS04465	COG2233	PERMEase
PF977_RS04470	COG2233	PERMEase
PF977_RS04475	COG2508	Transcriptional regulator
PF977_RS04480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF977_RS04490	COG1801	Protein of unknown function DUF72
PF977_RS04495	COG0730	response to heat
PF977_RS04500	COG0737	Belongs to the 5'-nucleotidase family
PF977_RS04505	COG3377	Domain of unknown function (DUF1805)
PF977_RS04515	COG0739	heme binding
PF977_RS04520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF977_RS04530	COG4470	Protein conserved in bacteria
PF977_RS04535	COG2445	Protein of unknown function DUF86
PF977_RS04540	COG0647	UMP catabolic process
PF977_RS04545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF977_RS04550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_RS04555	COG0460	homoserine dehydrogenase
PF977_RS04560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF977_RS04565	COG0083	homoserine kinase activity
PF977_RS04570	COG4946	Tricorn protease homolog
PF977_RS04570	COG1506	peptidase
PF977_RS04570	COG0823	Involved in the tonB-independent uptake of proteins
PF977_RS04575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PF977_RS04580	COG4837	Protein of unknown function (DUF1462)
PF977_RS04585	COG1252	NADH dehydrogenase
PF977_RS04590	COG4844	belongs to the
PF977_RS04595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_RS04600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PF977_RS04605	COG0316	Belongs to the HesB IscA family
PF977_RS04610	COG0456	acetyltransferase
PF977_RS04615	COG2808	Putative FMN-binding domain
PF977_RS04620	COG0516	GMP reductase activity
PF977_RS04630	COG0492	ferredoxin-NADP+ reductase activity
PF977_RS04635	COG1252	NADH dehydrogenase
PF977_RS04650	COG3584	3D domain protein
PF977_RS04655	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
PF977_RS04660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PF977_RS04665	COG2056	Na+-H+ antiporter family
PF977_RS04670	COG1268	BioY protein
PF977_RS04675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF977_RS04680	COG2819	hydrolase of the alpha beta superfamily
PF977_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS04690	COG1169	isochorismate synthase
PF977_RS04695	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF977_RS04700	COG1535	isochorismatase
PF977_RS04700	COG3433	isochorismatase activity
PF977_RS04705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS04710	COG3251	PFAM MbtH domain protein
PF977_RS04715	COG5634	Uncharacterized conserved protein (DUF2278)
PF977_RS04720	COG0686	Belongs to the AlaDH PNT family
PF977_RS04725	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF977_RS04725	COG2508	Transcriptional regulator
PF977_RS04730	COG4842	Belongs to the WXG100 family
PF977_RS04735	COG5417	Belongs to the EsaB family
PF977_RS04740	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF977_RS04745	COG0433	COG0433 Predicted ATPase
PF977_RS04745	COG1674	ftsk spoiiie
PF977_RS04750	COG1511	domain protein
PF977_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS04765	COG1418	mRNA catabolic process
PF977_RS04780	COG0628	permease
PF977_RS04795	COG5506	Protein of unknown function (DUF1694)
PF977_RS04800	COG1335	isochorismatase
PF977_RS04805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PF977_RS04810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PF977_RS04830	COG0142	geranyltranstransferase activity
PF977_RS04840	COG4585	Histidine kinase
PF977_RS04845	COG2197	response regulator
PF977_RS04850	COG2050	protein possibly involved in aromatic compounds catabolism
PF977_RS04855	COG1320	monovalent cation:proton antiporter activity
PF977_RS04860	COG2212	antiporter activity
PF977_RS04865	COG1863	multisubunit Na H antiporter MnhE subunit
PF977_RS04870	COG0651	ATP synthesis coupled electron transport
PF977_RS04875	COG1006	Multisubunit Na H antiporter MnhC subunit
PF977_RS04880	COG2111	Na H antiporter
PF977_RS04885	COG2111	Na H antiporter
PF977_RS04885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF977_RS04895	COG3493	citrate carrier protein
PF977_RS04900	COG1079	Belongs to the binding-protein-dependent transport system permease family
PF977_RS04905	COG4603	Belongs to the binding-protein-dependent transport system permease family
PF977_RS04910	COG3845	ABC transporter
PF977_RS04915	COG1744	ABC transporter substrate-binding protein PnrA-like
PF977_RS04920	COG4565	transcriptional regulatory protein
PF977_RS04925	COG3290	protein histidine kinase activity
PF977_RS04935	COG3011	Protein conserved in bacteria
PF977_RS04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_RS04945	COG2814	Major facilitator Superfamily
PF977_RS04955	COG5018	Exonuclease
PF977_RS04965	COG2205	protein histidine kinase activity
PF977_RS04970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PF977_RS04980	COG2267	carboxylic ester hydrolase activity
PF977_RS04985	COG1522	sequence-specific DNA binding
PF977_RS04990	COG0436	Aminotransferase
PF977_RS04995	COG1098	S1 RNA binding domain
PF977_RS05000	COG2155	Conserved Protein
PF977_RS05005	COG1979	alcohol dehydrogenase
PF977_RS05010	COG1979	alcohol dehydrogenase
PF977_RS05015	COG0166	Belongs to the GPI family
PF977_RS05030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF977_RS05045	COG2738	Putative neutral zinc metallopeptidase
PF977_RS05050	COG1253	flavin adenine dinucleotide binding
PF977_RS05055	COG0366	Alpha amylase catalytic
PF977_RS05065	COG0432	Pfam Uncharacterised protein family UPF0047
PF977_RS05080	COG0840	transmembrane signaling receptor activity
PF977_RS05085	COG0840	transmembrane signaling receptor activity
PF977_RS05090	COG0840	transmembrane signaling receptor activity
PF977_RS05095	COG0840	transmembrane signaling receptor activity
PF977_RS05100	COG3347	Dehydrogenase
PF977_RS05100	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS05105	COG1349	DNA-binding transcription factor activity
PF977_RS05110	COG1070	Carbohydrate kinase
PF977_RS05115	COG3254	rhamnose metabolic process
PF977_RS05120	COG4806	L-rhamnose isomerase
PF977_RS05125	COG0673	inositol 2-dehydrogenase activity
PF977_RS05130	COG0628	permease
PF977_RS05135	COG1968	undecaprenyl-diphosphatase activity
PF977_RS05145	COG5553	Cysteine dioxygenase type I
PF977_RS05150	COG0477	Major facilitator Superfamily
PF977_RS05155	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF977_RS05160	COG4682	membrane
PF977_RS05165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF977_RS05170	COG0569	domain protein
PF977_RS05180	COG1510	regulation of RNA biosynthetic process
PF977_RS05185	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS05190	COG1454	alcohol dehydrogenase
PF977_RS05200	COG2318	DinB family
PF977_RS05205	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF977_RS05210	COG2268	Band 7 protein
PF977_RS05215	COG1247	-acetyltransferase
PF977_RS05220	COG3859	Proton-coupled thiamine transporter YuaJ
PF977_RS05345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PF977_RS05350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PF977_RS05355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PF977_RS05360	COG0297	glycogen (starch) synthase activity
PF977_RS05365	COG0058	SHG alpha-glucan phosphorylase activity
PF977_RS05370	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PF977_RS05375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_RS05380	COG0438	transferase activity, transferring glycosyl groups
PF977_RS05385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_RS05395	COG0438	transferase activity, transferring glycosyl groups
PF977_RS05400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS05405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_RS05410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_RS05415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_RS05420	COG1169	isochorismate synthase
PF977_RS05425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PF977_RS05430	COG0596	Alpha beta hydrolase
PF977_RS05435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PF977_RS05440	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS05445	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_RS05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF977_RS05455	COG1121	(ABC) transporter
PF977_RS05460	COG1321	iron dependent repressor
PF977_RS05460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_RS05465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_RS05475	COG1294	oxidase, subunit
PF977_RS05480	COG1271	oxidase subunit
PF977_RS05485	COG0254	rRNA binding
PF977_RS05490	COG0288	reversible hydration of carbon dioxide
PF977_RS05495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PF977_RS05500	COG1854	S-ribosylhomocysteine lyase activity
PF977_RS05515	COG0783	Belongs to the Dps family
PF977_RS05520	COG4824	toxin secretion phage lysis holin
PF977_RS05525	COG0494	nUDIX hydrolase
PF977_RS05530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF977_RS05535	COG1116	anion transmembrane transporter activity
PF977_RS05540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF977_RS05545	COG1506	peptidase
PF977_RS05555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PF977_RS05560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PF977_RS05565	COG0367	asparagine synthase
PF977_RS05570	COG1113	amino acid transport
PF977_RS05575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF977_RS05580	COG2267	carboxylic ester hydrolase activity
PF977_RS05590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PF977_RS05595	COG1242	4 iron, 4 sulfur cluster binding
PF977_RS05610	COG1725	Transcriptional regulator
PF977_RS05615	COG1131	(ABC) transporter
PF977_RS05630	COG1136	(ABC) transporter
PF977_RS05635	COG0577	efflux transmembrane transporter activity
PF977_RS05640	COG0745	RESPONSE REGULATOR receiver
PF977_RS05645	COG2205	protein histidine kinase activity
PF977_RS05650	COG1136	(ABC) transporter
PF977_RS05655	COG0577	efflux transmembrane transporter activity
PF977_RS05660	COG2433	Pfam Transposase IS66
PF977_RS05665	COG2814	Major facilitator Superfamily
PF977_RS05670	COG2202	Pas domain
PF977_RS05670	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS05680	COG0495	leucyl-tRNA aminoacylation
PF977_RS05685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_RS05690	COG1486	melibiose metabolic process
PF977_RS05695	COG0395	ABC-type sugar transport system, permease component
PF977_RS05700	COG1175	transmembrane transport
PF977_RS05705	COG1653	transport
PF977_RS05710	COG1609	Transcriptional regulator
PF977_RS05715	COG1073	alpha beta
PF977_RS05725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_RS05730	COG0156	8-amino-7-oxononanoate synthase activity
PF977_RS05740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PF977_RS05745	COG2124	cytochrome p450
PF977_RS05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS05755	COG0395	ABC-type sugar transport system, permease component
PF977_RS05760	COG1653	transport
PF977_RS05765	COG2207	Transcriptional regulator
PF977_RS05770	COG4209	transmembrane transport
PF977_RS05775	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PF977_RS05780	COG1653	transport
PF977_RS05785	COG0673	inositol 2-dehydrogenase activity
PF977_RS05790	COG5578	integral membrane protein
PF977_RS05800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF977_RS05805	COG2081	HI0933 family
PF977_RS05810	COG2244	polysaccharide biosynthetic process
PF977_RS05815	COG1187	pseudouridine synthase activity
PF977_RS05820	COG1349	DNA-binding transcription factor activity
PF977_RS05825	COG1131	(ABC) transporter
PF977_RS05830	COG4473	ABC transporter
PF977_RS05835	COG2252	PERMEase
PF977_RS05840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_RS05845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_RS05850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF977_RS05860	COG1597	lipid kinase activity
PF977_RS05865	COG1523	belongs to the glycosyl hydrolase 13 family
PF977_RS05870	COG0510	thiamine kinase activity
PF977_RS05880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF977_RS05885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS05890	COG0281	malic enzyme
PF977_RS05895	COG5584	Small secreted protein
PF977_RS05900	COG1363	Peptidase, m42
PF977_RS05915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS05920	COG4848	Belongs to the UPF0354 family
PF977_RS05925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_RS05930	COG1674	ftsk spoiiie
PF977_RS05935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF977_RS05940	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF977_RS05945	COG4980	gas vesicle protein
PF977_RS05950	COG3118	belongs to the thioredoxin family
PF977_RS05955	COG1605	Chorismate mutase
PF977_RS05955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PF977_RS05960	COG1609	Transcriptional regulator
PF977_RS05965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF977_RS05970	COG1360	Flagellar Motor Protein
PF977_RS05975	COG0123	including yeast histone deacetylase and acetoin utilization protein
PF977_RS05980	COG0517	IMP dehydrogenase activity
PF977_RS05985	COG0454	-acetyltransferase
PF977_RS05990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF977_RS05995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF977_RS06005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PF977_RS06010	COG2203	Gaf domain
PF977_RS06010	COG2199	diguanylate cyclase activity
PF977_RS06015	COG1956	GAF domain-containing protein
PF977_RS06020	COG1309	transcriptional regulator
PF977_RS06025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF977_RS06030	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
PF977_RS06035	COG1114	Component of the transport system for branched-chain amino acids
PF977_RS06040	COG1104	cysteine desulfurase activity
PF977_RS06045	COG0301	tRNA thio-modification
PF977_RS06055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF977_RS06060	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PF977_RS06065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF977_RS06070	COG0616	signal peptide processing
PF977_RS06075	COG1714	RDD family
PF977_RS06085	COG3874	Sporulation protein YtfJ
PF977_RS06090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PF977_RS06095	COG0827	DNA restriction-modification system
PF977_RS06105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF977_RS06110	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF977_RS06115	COG0137	argininosuccinate synthase activity
PF977_RS06120	COG0165	Argininosuccinate lyase
PF977_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS06135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PF977_RS06140	COG0583	DNA-binding transcription factor activity
PF977_RS06145	COG0454	-acetyltransferase
PF977_RS06150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS06155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS06160	COG0765	amino acid transport
PF977_RS06165	COG0765	amino acid transport
PF977_RS06170	COG1126	abc transporter atp-binding protein
PF977_RS06175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS06180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF977_RS06185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS06190	COG0196	riboflavin kinase activity
PF977_RS06195	COG1473	amidohydrolase
PF977_RS06200	COG0730	response to heat
PF977_RS06205	COG4109	DRTGG domain
PF977_RS06215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PF977_RS06235	COG0587	DNA-directed DNA polymerase activity
PF977_RS06240	COG0281	malic enzyme
PF977_RS06245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PF977_RS06250	COG0825	malonyl-CoA metabolic process
PF977_RS06255	COG0205	6-phosphofructokinase activity
PF977_RS06260	COG0469	pyruvate kinase activity
PF977_RS06265	COG3030	protein affecting phage T7 exclusion by the F plasmid
PF977_RS06270	COG0628	permease
PF977_RS06275	COG2707	UPF0756 membrane protein
PF977_RS06280	COG0372	Belongs to the citrate synthase family
PF977_RS06285	COG0538	isocitrate dehydrogenase activity
PF977_RS06290	COG0039	L-malate dehydrogenase activity
PF977_RS06295	COG0745	RESPONSE REGULATOR receiver
PF977_RS06300	COG5002	protein histidine kinase activity
PF977_RS06305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_RS06305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_RS06310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PF977_RS06315	COG1971	Probably functions as a manganese efflux pump
PF977_RS06320	COG0237	dephospho-CoA kinase activity
PF977_RS06325	COG0656	L-ascorbic acid biosynthetic process
PF977_RS06330	COG2814	Major facilitator Superfamily
PF977_RS06335	COG1733	regulation of RNA biosynthetic process
PF977_RS06340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF977_RS06345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PF977_RS06350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF977_RS06355	COG3611	Membrane attachment protein
PF977_RS06360	COG1484	DNA-dependent DNA replication
PF977_RS06365	COG0398	Pfam SNARE associated Golgi protein
PF977_RS06375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF977_RS06380	COG1011	Hydrolase
PF977_RS06385	COG3275	phosphorelay sensor kinase activity
PF977_RS06390	COG3279	Response regulator of the LytR AlgR family
PF977_RS06395	COG1380	Effector of murein hydrolase LrgA
PF977_RS06400	COG1346	cytolysis
PF977_RS06410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PF977_RS06415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PF977_RS06420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PF977_RS06425	COG3326	Membrane
PF977_RS06435	COG1363	Peptidase, m42
PF977_RS06440	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_RS06445	COG2160	L-arabinose isomerase activity
PF977_RS06450	COG1069	ribulokinase activity
PF977_RS06455	COG0235	Class ii aldolase
PF977_RS06460	COG0647	UMP catabolic process
PF977_RS06465	COG0371	Dehydrogenase
PF977_RS06470	COG1653	transport
PF977_RS06475	COG1175	transmembrane transport
PF977_RS06480	COG0395	ABC-type sugar transport system, permease component
PF977_RS06485	COG3534	alpha-L-arabinofuranosidase
PF977_RS06490	COG1966	Carbon starvation protein
PF977_RS06500	COG0346	lactoylglutathione lyase activity
PF977_RS06505	COG0247	lactate metabolic process
PF977_RS06510	COG0277	FAD linked oxidase domain protein
PF977_RS06515	COG3835	regulator
PF977_RS06525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF977_RS06535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PF977_RS06540	COG0072	phenylalanine-tRNA ligase activity
PF977_RS06540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_RS06545	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF977_RS06550	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PF977_RS06555	COG1286	toxin biosynthetic process
PF977_RS06560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF977_RS06560	COG1796	DNA polymerase
PF977_RS06565	COG1193	negative regulation of DNA recombination
PF977_RS06570	COG3766	membrane
PF977_RS06575	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS06580	COG1309	transcriptional regulator
PF977_RS06585	COG1024	Enoyl-CoA hydratase
PF977_RS06590	COG2086	electron transfer activity
PF977_RS06595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PF977_RS06600	COG3534	alpha-L-arabinofuranosidase
PF977_RS06605	COG3118	belongs to the thioredoxin family
PF977_RS06610	COG0322	excinuclease ABC activity
PF977_RS06615	COG0527	aspartate kinase activity
PF977_RS06620	COG1719	4-vinyl reductase, 4VR
PF977_RS06625	COG2009	succinate dehydrogenase
PF977_RS06630	COG1053	succinate dehydrogenase
PF977_RS06635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF977_RS06640	COG0824	Thioesterase
PF977_RS06645	COG2197	response regulator
PF977_RS06650	COG1846	Transcriptional regulator
PF977_RS06655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF977_RS06660	COG5401	PFAM Sporulation and spore germination
PF977_RS06665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PF977_RS06670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PF977_RS06675	COG0622	Phosphoesterase
PF977_RS06685	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
PF977_RS06690	COG0454	-acetyltransferase
PF977_RS06700	COG0028	Belongs to the TPP enzyme family
PF977_RS06705	COG0440	acetolactate synthase activity
PF977_RS06710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PF977_RS06715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF977_RS06720	COG0473	3-isopropylmalate dehydrogenase activity
PF977_RS06725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PF977_RS06730	COG0066	3-isopropylmalate dehydratase activity
PF977_RS06735	COG1477	protein flavinylation
PF977_RS06735	COG0457	Tetratricopeptide repeat
PF977_RS06740	COG0544	peptidyl-prolyl cis-trans isomerase activity
PF977_RS06745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PF977_RS06750	COG0470	DNA polymerase III
PF977_RS06750	COG1067	ATP-dependent peptidase activity
PF977_RS06755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF977_RS06760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PF977_RS06770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PF977_RS06775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF977_RS06780	COG0181	hydroxymethylbilane synthase activity
PF977_RS06785	COG1587	Uroporphyrinogen-III synthase
PF977_RS06790	COG0113	porphobilinogen synthase activity
PF977_RS06795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PF977_RS06800	COG1388	LysM domain
PF977_RS06805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_RS06815	COG0525	valine-tRNA ligase activity
PF977_RS06820	COG0285	dihydrofolate synthase activity
PF977_RS06825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PF977_RS06835	COG0424	maF-like protein
PF977_RS06840	COG2003	Belongs to the UPF0758 family
PF977_RS06845	COG1077	Cell shape determining protein MreB Mrl
PF977_RS06855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF977_RS06860	COG0850	regulation of cytokinetic process
PF977_RS06865	COG2894	cell division
PF977_RS06870	COG0739	heme binding
PF977_RS06875	COG1994	Peptidase M50
PF977_RS06880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PF977_RS06885	COG2868	ribosomal protein
PF977_RS06890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PF977_RS06900	COG3290	protein histidine kinase activity
PF977_RS06905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PF977_RS06910	COG4492	Belongs to the UPF0735 family
PF977_RS06915	COG0077	Prephenate dehydratase
PF977_RS06920	COG1827	regulation of RNA biosynthetic process
PF977_RS06925	COG1104	cysteine desulfurase activity
PF977_RS06930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PF977_RS06935	COG0157	Belongs to the NadC ModD family
PF977_RS06940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF977_RS06945	COG1388	LysM domain
PF977_RS06955	COG0217	transcriptional regulatory protein
PF977_RS06960	COG1115	amino acid carrier protein
PF977_RS06985	COG2112	serine threonine protein kinase
PF977_RS06990	COG0673	inositol 2-dehydrogenase activity
PF977_RS06995	COG2814	Major facilitator Superfamily
PF977_RS07005	COG0632	four-way junction helicase activity
PF977_RS07010	COG2255	four-way junction helicase activity
PF977_RS07020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PF977_RS07025	COG0343	queuine tRNA-ribosyltransferase activity
PF977_RS07030	COG1862	Preprotein translocase
PF977_RS07040	COG2323	membrane
PF977_RS07045	COG2244	polysaccharide biosynthetic process
PF977_RS07055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF977_RS07055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF977_RS07060	COG0490	domain, Protein
PF977_RS07065	COG5416	Lipopolysaccharide assembly protein A domain
PF977_RS07070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF977_RS07070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PF977_RS07075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_RS07080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF977_RS07085	COG1490	D-aminoacyl-tRNA deacylase activity
PF977_RS07090	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS07090	COG3103	Sh3 type 3 domain protein
PF977_RS07090	COG4991	sh3 domain protein
PF977_RS07100	COG0124	histidyl-tRNA synthetase
PF977_RS07105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PF977_RS07115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF977_RS07120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF977_RS07125	COG1959	2 iron, 2 sulfur cluster binding
PF977_RS07130	COG1104	cysteine desulfurase activity
PF977_RS07135	COG0482	sulfurtransferase activity
PF977_RS07140	COG0457	Tetratricopeptide repeat
PF977_RS07145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF977_RS07150	COG3881	PFAM PRC-barrel domain
PF977_RS07165	COG0765	amino acid transport
PF977_RS07170	COG0765	amino acid transport
PF977_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS07180	COG1126	abc transporter atp-binding protein
PF977_RS07185	COG0628	permease
PF977_RS07190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PF977_RS07195	COG4472	Bacterial protein of unknown function (DUF965)
PF977_RS07200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF977_RS07205	COG3906	Belongs to the UPF0473 family
PF977_RS07210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF977_RS07215	COG4122	O-methyltransferase activity
PF977_RS07220	COG0826	peptidase U32
PF977_RS07225	COG0826	peptidase U32
PF977_RS07230	COG0572	uridine kinase
PF977_RS07235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF977_RS07240	COG0768	penicillin binding
PF977_RS07255	COG2226	methyltransferase
PF977_RS07260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF977_RS07265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_RS07270	COG0626	cystathionine gamma-synthase activity
PF977_RS07280	COG2427	Protein of unknown function (DUF1641)
PF977_RS07285	COG3383	formate dehydrogenase (NAD+) activity
PF977_RS07290	COG5609	conserved protein (DUF2294)
PF977_RS07295	COG2116	formate transmembrane transporter activity
PF977_RS07310	COG2226	methyltransferase
PF977_RS07315	COG1309	transcriptional regulator
PF977_RS07320	COG2124	cytochrome p450
PF977_RS07320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_RS07330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS07335	COG1131	(ABC) transporter
PF977_RS07355	COG2084	Dehydrogenase
PF977_RS07360	COG2986	histidine ammonia-lyase
PF977_RS07365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF977_RS07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_RS07410	COG1378	Sugar-specific transcriptional regulator TrmB
PF977_RS07415	COG1280	lysine exporter protein (LysE YggA)
PF977_RS07420	COG1113	amino acid transport
PF977_RS07430	COG3933	PFAM sigma-54 factor interaction domain-containing protein
PF977_RS07430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF977_RS07435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS07440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS07445	COG3715	PTS system
PF977_RS07450	COG3716	PTS system mannose fructose sorbose family IID component
PF977_RS07460	COG1621	beta-fructofuranosidase activity
PF977_RS07465	COG0693	protein deglycase activity
PF977_RS07470	COG1064	alcohol dehydrogenase
PF977_RS07480	COG0789	Transcriptional regulator
PF977_RS07485	COG5577	PFAM Coat F domain
PF977_RS07495	COG1063	alcohol dehydrogenase
PF977_RS07500	COG5577	PFAM Coat F domain
PF977_RS07510	COG0346	lactoylglutathione lyase activity
PF977_RS07520	COG4991	sh3 domain protein
PF977_RS07525	COG4991	sh3 domain protein
PF977_RS07530	COG0596	Alpha beta hydrolase
PF977_RS07535	COG5566	PFAM Mor transcription activator
PF977_RS07540	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS07545	COG2828	Protein conserved in bacteria
PF977_RS07550	COG0583	DNA-binding transcription factor activity
PF977_RS07555	COG2851	Citrate transporter
PF977_RS07560	COG0667	Aldo Keto reductase
PF977_RS07565	COG1595	DNA-templated transcription, initiation
PF977_RS07570	COG3443	Belongs to the bacterial solute-binding protein 9 family
PF977_RS07585	COG2315	Protein conserved in bacteria
PF977_RS07590	COG4978	Transcriptional regulator
PF977_RS07590	COG0789	Transcriptional regulator
PF977_RS07600	COG3959	Transketolase, thiamine diphosphate binding domain
PF977_RS07605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PF977_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS07625	COG2186	Transcriptional regulator
PF977_RS07635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF977_RS07645	COG2070	2-Nitropropane dioxygenase
PF977_RS07655	COG2318	DinB family
PF977_RS07670	COG1335	isochorismatase
PF977_RS07680	COG2124	cytochrome p450
PF977_RS07690	COG1522	sequence-specific DNA binding
PF977_RS07695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF977_RS07700	COG1687	branched-chain amino acid
PF977_RS07705	COG1114	Component of the transport system for branched-chain amino acids
PF977_RS07715	COG0583	DNA-binding transcription factor activity
PF977_RS07720	COG1942	4-Oxalocrotonate Tautomerase
PF977_RS07725	COG1230	cation diffusion facilitator family transporter
PF977_RS07730	COG2072	flavoprotein involved in K transport
PF977_RS07735	COG0583	DNA-binding transcription factor activity
PF977_RS07740	COG0697	spore germination
PF977_RS07750	COG1253	flavin adenine dinucleotide binding
PF977_RS07755	COG0456	acetyltransferase
PF977_RS07760	COG2814	Major facilitator Superfamily
PF977_RS07765	COG4978	Transcriptional regulator
PF977_RS07765	COG0789	Transcriptional regulator
PF977_RS07780	COG0662	Cupin 2, conserved barrel domain protein
PF977_RS07790	COG1937	Protein conserved in bacteria
PF977_RS07795	COG2210	Belongs to the sulfur carrier protein TusA family
PF977_RS07800	COG0425	Belongs to the sulfur carrier protein TusA family
PF977_RS07800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_RS07815	COG0425	Belongs to the sulfur carrier protein TusA family
PF977_RS07820	COG0730	response to heat
PF977_RS07825	COG4124	Belongs to the glycosyl hydrolase 26 family
PF977_RS07845	COG2856	Zn peptidase
PF977_RS07850	COG0563	adenylate kinase activity
PF977_RS07860	COG3620	sequence-specific DNA binding
PF977_RS07865	COG1476	TRANSCRIPTIONal
PF977_RS07895	COG5377	YqaJ viral recombinase family
PF977_RS07900	COG3723	Recombinational DNA repair protein, rece pathway
PF977_RS07905	COG3935	DnaD domain protein
PF977_RS07910	COG1484	DNA-dependent DNA replication
PF977_RS07920	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
PF977_RS07940	COG3677	Transposase
PF977_RS07955	COG5484	DNA packaging
PF977_RS07960	COG1783	phage Terminase large subunit
PF977_RS07965	COG5518	Phage portal protein
PF977_RS07970	COG2369	cell adhesion
PF977_RS07980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PF977_RS07985	COG4653	Phage capsid family
PF977_RS08045	COG5280	Phage tail tape measure protein TP901
PF977_RS08045	COG3953	SLT domain
PF977_RS08050	COG1652	LysM domain
PF977_RS08055	COG4193	domain, Protein
PF977_RS08065	COG3628	GPW Gp25 family protein
PF977_RS08075	COG3778	Protein conserved in bacteria
PF977_RS08105	COG4824	toxin secretion phage lysis holin
PF977_RS08110	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS08110	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS08135	COG5444	nuclease activity
PF977_RS08150	COG0457	Tetratricopeptide repeat
PF977_RS08170	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_RS08175	COG0604	alcohol dehydrogenase
PF977_RS08195	COG3403	YqcI/YcgG family
PF977_RS08200	COG0640	Transcriptional regulator
PF977_RS08205	COG0346	lactoylglutathione lyase activity
PF977_RS08210	COG0798	PFAM Bile acid sodium symporter
PF977_RS08215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_RS08225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF977_RS08235	COG3209	COG3209 Rhs family protein
PF977_RS08245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PF977_RS08250	COG0398	Pfam SNARE associated Golgi protein
PF977_RS08255	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS08255	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS08260	COG2755	lipolytic protein G-D-S-L family
PF977_RS08270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PF977_RS08275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF977_RS08280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF977_RS08285	COG1534	Rna-binding protein
PF977_RS08290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PF977_RS08295	COG1713	HD superfamily hydrolase involved in NAD metabolism
PF977_RS08300	COG0799	negative regulation of ribosome biogenesis
PF977_RS08305	COG2226	methyltransferase
PF977_RS08310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_RS08315	COG1596	polysaccharide export
PF977_RS08315	COG1555	photosystem II stabilization
PF977_RS08320	COG2131	deaminase
PF977_RS08325	COG0658	competence protein
PF977_RS08325	COG2333	competence protein COMEC
PF977_RS08340	COG1466	dna polymerase III delta subunit
PF977_RS08345	COG0268	Binds directly to 16S ribosomal RNA
PF977_RS08350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PF977_RS08355	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS08365	COG0481	GTPase activity
PF977_RS08370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF977_RS08375	COG1420	regulation of RNA biosynthetic process
PF977_RS08380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PF977_RS08385	COG0443	Heat shock 70 kDa protein
PF977_RS08390	COG0484	heat shock protein binding
PF977_RS08395	COG2264	protein methyltransferase activity
PF977_RS08400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF977_RS08405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF977_RS08410	COG1283	sodium-dependent phosphate transmembrane transporter activity
PF977_RS08420	COG1610	YqeY-like protein
PF977_RS08425	COG1030	water channel activity
PF977_RS08430	COG4864	UPF0365 protein
PF977_RS08445	COG0561	phosphatase activity
PF977_RS08450	COG1702	phosphate starvation-inducible protein PhoH
PF977_RS08455	COG1480	7TM receptor with intracellular HD hydrolase
PF977_RS08460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PF977_RS08465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PF977_RS08470	COG0295	cytidine deaminase activity
PF977_RS08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF977_RS08485	COG1381	Involved in DNA repair and RecF pathway recombination
PF977_RS08490	COG0752	glycyl-tRNA synthetase alpha subunit
PF977_RS08495	COG0751	glycine-tRNA ligase activity
PF977_RS08500	COG0517	IMP dehydrogenase activity
PF977_RS08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PF977_RS08510	COG1671	Belongs to the UPF0178 family
PF977_RS08515	COG0358	DNA primase activity
PF977_RS08520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PF977_RS08525	COG2010	Cytochrome c
PF977_RS08530	COG2384	SAM-dependent methyltransferase
PF977_RS08535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF977_RS08540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PF977_RS08550	COG0513	Belongs to the DEAD box helicase family
PF977_RS08555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PF977_RS08565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS08570	COG0735	belongs to the Fur family
PF977_RS08575	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
PF977_RS08580	COG4709	membrane
PF977_RS08585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PF977_RS08590	COG1388	LysM domain
PF977_RS08595	COG5521	maltodextrose utilization protein MalA
PF977_RS08600	COG2839	Protein conserved in bacteria
PF977_RS08605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF977_RS08610	COG0477	Major facilitator Superfamily
PF977_RS08615	COG0768	penicillin binding
PF977_RS08620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF977_RS08625	COG0573	inorganic phosphate transmembrane transporter activity
PF977_RS08630	COG0581	inorganic phosphate transmembrane transporter activity
PF977_RS08635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_RS08640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_RS08645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF977_RS08660	COG0438	transferase activity, transferring glycosyl groups
PF977_RS08670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF977_RS08680	COG0457	Tetratricopeptide repeat
PF977_RS08680	COG0705	Rhomboid family
PF977_RS08685	COG4483	Protein conserved in bacteria
PF977_RS08690	COG1940	carbohydrate kinase activity
PF977_RS08695	COG1368	sulfuric ester hydrolase activity
PF977_RS08700	COG2866	Carboxypeptidase
PF977_RS08710	COG0011	TIGRFAM Protein of
PF977_RS08720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS08730	COG1393	Belongs to the ArsC family
PF977_RS08740	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS08745	COG1253	flavin adenine dinucleotide binding
PF977_RS08750	COG0598	Magnesium transport protein CorA
PF977_RS08755	COG0517	IMP dehydrogenase activity
PF977_RS08760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF977_RS08765	COG1459	type II secretion system
PF977_RS08770	COG4537	Required for transformation and DNA binding
PF977_RS08775	COG4970	Tfp pilus assembly protein FimT
PF977_RS08785	COG4940	Competence protein ComGF
PF977_RS08810	COG0681	Belongs to the peptidase S26 family
PF977_RS08820	COG1396	sequence-specific DNA binding
PF977_RS08835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF977_RS08840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PF977_RS08845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF977_RS08850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF977_RS08855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_RS08860	COG0095	Lipoate-protein ligase
PF977_RS08865	COG1321	iron dependent repressor
PF977_RS08870	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF977_RS08880	COG3872	metal-dependent enzyme
PF977_RS08890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PF977_RS08895	COG0006	proline dipeptidase activity
PF977_RS08900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PF977_RS08910	COG3854	ATPases associated with a variety of cellular activities
PF977_RS08950	COG0511	ligase activity, forming carbon-carbon bonds
PF977_RS08955	COG0439	Biotin carboxylase
PF977_RS08960	COG1302	Protein conserved in bacteria
PF977_RS08965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF977_RS08970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PF977_RS08975	COG1570	exodeoxyribonuclease VII activity
PF977_RS08980	COG1722	exodeoxyribonuclease VII activity
PF977_RS08985	COG0142	geranyltranstransferase activity
PF977_RS08990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PF977_RS08995	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PF977_RS09000	COG1438	arginine binding
PF977_RS09005	COG0497	DNA recombination
PF977_RS09010	COG0750	zinc metalloprotease
PF977_RS09015	COG0745	RESPONSE REGULATOR receiver
PF977_RS09020	COG1902	pentaerythritol trinitrate reductase activity
PF977_RS09035	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS09040	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_RS09045	COG0183	Belongs to the thiolase family
PF977_RS09050	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF977_RS09055	COG1960	acyl-CoA dehydrogenase activity
PF977_RS09060	COG0372	Belongs to the citrate synthase family
PF977_RS09065	COG2079	MmgE PrpD family protein
PF977_RS09070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PF977_RS09080	COG3290	protein histidine kinase activity
PF977_RS09080	COG3829	transcription factor binding
PF977_RS09085	COG0280	phosphate acetyltransferase
PF977_RS09090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_RS09095	COG3426	butyrate kinase activity
PF977_RS09100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_RS09105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_RS09110	COG0022	dehydrogenase e1 component
PF977_RS09115	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_RS09120	COG0789	Transcriptional regulator
PF977_RS09120	COG4978	Transcriptional regulator
PF977_RS09125	COG2814	Major facilitator Superfamily
PF977_RS09130	COG1597	lipid kinase activity
PF977_RS09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS09145	COG0765	amino acid transport
PF977_RS09150	COG1126	abc transporter atp-binding protein
PF977_RS09155	COG4129	membrane
PF977_RS09160	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_RS09170	COG0346	lactoylglutathione lyase activity
PF977_RS09175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF977_RS09180	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF977_RS09185	COG3361	conserved protein (COG2071)
PF977_RS09190	COG0706	membrane insertase activity
PF977_RS09200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_RS09205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF977_RS09210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PF977_RS09215	COG1234	tRNA 3'-trailer cleavage
PF977_RS09225	COG0596	Alpha beta hydrolase
PF977_RS09230	COG1902	pentaerythritol trinitrate reductase activity
PF977_RS09235	COG4187	Peptidase family M20/M25/M40
PF977_RS09240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_RS09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS09250	COG0300	oxidoreductase activity
PF977_RS09255	COG3048	D-serine ammonia-lyase activity
PF977_RS09260	COG1072	(Pantothenic acid kinase))
PF977_RS09265	COG0346	lactoylglutathione lyase activity
PF977_RS09275	COG2211	Major facilitator Superfamily
PF977_RS09285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_RS09295	COG0456	acetyltransferase
PF977_RS09300	COG2329	Antibiotic biosynthesis monooxygenase
PF977_RS09305	COG0456	acetyltransferase
PF977_RS09305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF977_RS09310	COG4918	Iron-sulphur cluster biosynthesis
PF977_RS09320	COG1073	alpha beta
PF977_RS09330	COG0667	Aldo Keto reductase
PF977_RS09340	COG0494	nUDIX hydrolase
PF977_RS09345	COG1379	DNA repair
PF977_RS09350	COG1396	sequence-specific DNA binding
PF977_RS09355	COG0252	asparaginase activity
PF977_RS09360	COG1027	Aspartate ammonia-lyase
PF977_RS09365	COG1757	Na H antiporter
PF977_RS09370	COG0281	malic enzyme
PF977_RS09380	COG1300	Membrane
PF977_RS09385	COG0735	belongs to the Fur family
PF977_RS09395	COG4974	Belongs to the 'phage' integrase family
PF977_RS09400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PF977_RS09405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PF977_RS09410	COG1686	Belongs to the peptidase S11 family
PF977_RS09415	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS09420	COG2172	sigma factor antagonist activity
PF977_RS09425	COG1191	sigma factor activity
PF977_RS09445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_RS09460	COG0697	spore germination
PF977_RS09465	COG0019	diaminopimelate decarboxylase activity
PF977_RS09470	COG4086	secreted protein
PF977_RS09475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF977_RS09495	COG2433	Pfam Transposase IS66
PF977_RS09510	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
PF977_RS09520	COG0681	Belongs to the peptidase S26 family
PF977_RS09530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF977_RS09530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF977_RS09535	COG0307	riboflavin synthase, alpha
PF977_RS09540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF977_RS09540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF977_RS09545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PF977_RS09550	COG0456	acetyltransferase
PF977_RS09555	COG1547	Domain of unknown function (DUF309)
PF977_RS09560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF977_RS09565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF977_RS09575	COG1686	Belongs to the peptidase S11 family
PF977_RS09580	COG2715	membrane protein required for spore maturation
PF977_RS09585	COG0700	Nucleoside recognition
PF977_RS09590	COG1187	pseudouridine synthase activity
PF977_RS09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS09600	COG1333	cytochrome c biogenesis protein
PF977_RS09605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF977_RS09610	COG0745	RESPONSE REGULATOR receiver
PF977_RS09615	COG5002	protein histidine kinase activity
PF977_RS09620	COG1595	DNA-templated transcription, initiation
PF977_RS09630	COG0710	3-dehydroquinate dehydratase activity
PF977_RS09635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF977_RS09640	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PF977_RS09645	COG1141	Ferredoxin
PF977_RS09650	COG4955	Helix-turn-helix domain
PF977_RS09655	COG0514	ATP-dependent DNA helicase (RecQ)
PF977_RS09660	COG1266	CAAX protease self-immunity
PF977_RS09665	COG1388	LysM domain
PF977_RS09675	COG1408	metallophosphoesterase
PF977_RS09680	COG4862	establishment of competence for transformation
PF977_RS09685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_RS09690	COG0492	ferredoxin-NADP+ reductase activity
PF977_RS09695	COG2339	peptidase activity
PF977_RS09700	COG3773	Cell wall hydrolase
PF977_RS09700	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS09705	COG2959	enzyme of heme biosynthesis
PF977_RS09710	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PF977_RS09720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PF977_RS09725	COG0539	negative regulation of cytoplasmic translation
PF977_RS09730	COG1304	FMN binding
PF977_RS09755	COG1160	GTP binding
PF977_RS09760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PF977_RS09775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF977_RS09780	COG0776	regulation of translation
PF977_RS09785	COG0302	gtp cyclohydrolase
PF977_RS09795	COG0142	geranyltranstransferase activity
PF977_RS09800	COG2226	methyltransferase
PF977_RS09805	COG0142	geranyltranstransferase activity
PF977_RS09810	COG0105	UTP biosynthetic process
PF977_RS09815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF977_RS09820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PF977_RS09825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PF977_RS09830	COG4401	Chorismate mutase type I
PF977_RS09835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF977_RS09840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF977_RS09850	COG0135	phosphoribosylanthranilate isomerase activity
PF977_RS09855	COG0133	tryptophan synthase activity
PF977_RS09860	COG0159	tryptophan synthase activity
PF977_RS09865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PF977_RS09870	COG0287	Prephenate dehydrogenase
PF977_RS09875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF977_RS09880	COG0457	Tetratricopeptide repeat
PF977_RS09885	COG5582	Belongs to the UPF0302 family
PF977_RS09895	COG0723	plastoquinol--plastocyanin reductase activity
PF977_RS09900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF977_RS09905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF977_RS09905	COG2010	Cytochrome c
PF977_RS09910	COG4347	Protein of unknown function (DUF1405)
PF977_RS09920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS09925	COG1694	Mazg nucleotide pyrophosphohydrolase
PF977_RS09930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PF977_RS09935	COG1803	Methylglyoxal synthase
PF977_RS09940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_RS09945	COG0438	transferase activity, transferring glycosyl groups
PF977_RS09950	COG0617	tRNA 3'-terminal CCA addition
PF977_RS09955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PF977_RS09955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PF977_RS09960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PF977_RS09965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PF977_RS09970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PF977_RS09975	COG1199	ATP-dependent helicase activity
PF977_RS09975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF977_RS09985	COG5353	protein conserved in bacteria
PF977_RS09990	COG0436	Aminotransferase
PF977_RS09995	COG0017	Asparaginyl-tRNA synthetase
PF977_RS10000	COG3935	DnaD domain protein
PF977_RS10005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF977_RS10015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_RS10015	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF977_RS10020	COG3331	DNA recombination
PF977_RS10055	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_RS10060	COG2190	(PTS) system
PF977_RS10065	COG1111	helicase
PF977_RS10065	COG1205	dead DEAH box helicase
PF977_RS10070	COG3359	exonuclease
PF977_RS10085	COG4474	Belongs to the UPF0398 family
PF977_RS10100	COG0116	Belongs to the methyltransferase superfamily
PF977_RS10115	COG1199	ATP-dependent helicase activity
PF977_RS10120	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS10125	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PF977_RS10130	COG1609	Transcriptional regulator
PF977_RS10135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_RS10140	COG0800	Aldolase
PF977_RS10150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PF977_RS10155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_RS10160	COG2233	PERMEase
PF977_RS10165	COG3424	synthase
PF977_RS10170	COG1755	Isoprenylcysteine carboxyl methyltransferase
PF977_RS10180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF977_RS10195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_RS10205	COG0328	RNA-DNA hybrid ribonuclease activity
PF977_RS10210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PF977_RS10215	COG0328	RNA-DNA hybrid ribonuclease activity
PF977_RS10235	COG1278	Cold shock
PF977_RS10245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_RS10250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PF977_RS10255	COG0386	Belongs to the glutathione peroxidase family
PF977_RS10260	COG1418	mRNA catabolic process
PF977_RS10265	COG1413	lyase activity
PF977_RS10270	COG0129	dihydroxy-acid dehydratase activity
PF977_RS10280	COG2136	Putative SAM-dependent methyltransferase
PF977_RS10280	COG2521	methyltransferase
PF977_RS10290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF977_RS10295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF977_RS10300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_RS10305	COG0204	Acyl-transferase
PF977_RS10310	COG1272	protein, Hemolysin III
PF977_RS10315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF977_RS10320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF977_RS10330	COG1999	signal sequence binding
PF977_RS10335	COG2755	lipolytic protein G-D-S-L family
PF977_RS10340	COG4698	Protein conserved in bacteria
PF977_RS10350	COG0534	Mate efflux family protein
PF977_RS10355	COG1846	Transcriptional regulator
PF977_RS10360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF977_RS10365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF977_RS10370	COG1086	Polysaccharide biosynthesis protein
PF977_RS10375	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
PF977_RS10380	COG4641	Protein conserved in bacteria
PF977_RS10395	COG0463	Glycosyl transferase, family 2
PF977_RS10400	COG0456	acetyltransferase
PF977_RS10415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_RS10420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF977_RS10425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF977_RS10430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_RS10435	COG0456	acetyltransferase
PF977_RS10440	COG1509	lysine 2,3-aminomutase activity
PF977_RS10450	COG4479	Belongs to the UPF0346 family
PF977_RS10470	COG0671	phosphoesterase, PA-phosphatase related
PF977_RS10485	COG0813	purine-nucleoside phosphorylase activity
PF977_RS10490	COG1876	peptidase activity
PF977_RS10500	COG2226	methyltransferase
PF977_RS10505	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS10505	COG0793	Belongs to the peptidase S41A family
PF977_RS10510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_RS10520	COG0346	lactoylglutathione lyase activity
PF977_RS10525	COG0400	carboxylic ester hydrolase activity
PF977_RS10530	COG0778	Nitroreductase
PF977_RS10535	COG1733	regulation of RNA biosynthetic process
PF977_RS10540	COG1942	4-Oxalocrotonate Tautomerase
PF977_RS10545	COG2610	gluconate transmembrane transporter activity
PF977_RS10560	COG2962	Rard protein
PF977_RS10570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_RS10575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_RS10580	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS10585	COG0534	Mate efflux family protein
PF977_RS10590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF977_RS10595	COG1819	glycosyl
PF977_RS10600	COG0791	NLP P60 protein
PF977_RS10600	COG1388	LysM domain
PF977_RS10605	COG2032	superoxide dismutase activity
PF977_RS10610	COG0714	Associated with various cellular activities
PF977_RS10615	COG4548	von Willebrand factor, type A
PF977_RS10620	COG0567	Dehydrogenase, E1 component
PF977_RS10625	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_RS10630	COG0385	Bile acid
PF977_RS10635	COG0733	neurotransmitter:sodium symporter activity
PF977_RS10640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF977_RS10645	COG1657	PFAM Prenyltransferase squalene oxidase
PF977_RS10650	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS10675	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_RS10690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_RS10695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF977_RS10705	COG0514	ATP-dependent DNA helicase (RecQ)
PF977_RS10710	COG1388	LysM domain
PF977_RS10710	COG3584	3D domain protein
PF977_RS10715	COG2197	response regulator
PF977_RS10720	COG4585	Histidine kinase
PF977_RS10725	COG3239	Fatty acid desaturase
PF977_RS10730	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF977_RS10745	COG2322	membrane
PF977_RS10750	COG0741	lytic transglycosylase activity
PF977_RS10755	COG0640	Transcriptional regulator
PF977_RS10765	COG2378	regulation of single-species biofilm formation
PF977_RS10770	COG3708	Transcriptional regulator
PF977_RS10775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS10780	COG1309	transcriptional regulator
PF977_RS10785	COG0456	acetyltransferase
PF977_RS10790	COG2207	Transcriptional regulator
PF977_RS10790	COG0662	Cupin 2, conserved barrel domain protein
PF977_RS10795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_RS10805	COG3646	Phage regulatory protein
PF977_RS10805	COG3645	SOS response
PF977_RS10930	COG5280	Phage tail tape measure protein TP901
PF977_RS10930	COG3953	SLT domain
PF977_RS10945	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_RS10965	COG4824	toxin secretion phage lysis holin
PF977_RS10970	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS11010	COG0582	viral genome integration into host DNA
PF977_RS11015	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_RS11020	COG1231	oxidoreductase activity
PF977_RS11025	COG4282	regulation of fungal-type cell wall biogenesis
PF977_RS11060	COG2314	TM2 domain
PF977_RS11065	COG0726	polysaccharide deacetylase
PF977_RS11070	COG0574	Belongs to the PEP-utilizing enzyme family
PF977_RS11070	COG3848	Pyruvate phosphate dikinase
PF977_RS11095	COG2367	Beta-lactamase
PF977_RS11100	COG0693	protein deglycase activity
PF977_RS11110	COG0697	spore germination
PF977_RS11115	COG0583	DNA-binding transcription factor activity
PF977_RS11120	COG3739	integral membrane protein
PF977_RS11125	COG3655	Transcriptional regulator
PF977_RS11135	COG2720	vancomycin resistance protein
PF977_RS11155	COG0456	acetyltransferase
PF977_RS11165	COG2140	Oxalate decarboxylase
PF977_RS11175	COG2135	peptidase activity
PF977_RS11180	COG3866	Pectate lyase
PF977_RS11185	COG3619	membrane
PF977_RS11190	COG4305	rare lipoprotein A
PF977_RS11195	COG2368	4-hydroxyphenylacetate
PF977_RS11200	COG5278	phosphoserine phosphatase activity
PF977_RS11200	COG0840	transmembrane signaling receptor activity
PF977_RS11230	COG0243	molybdopterin cofactor binding
PF977_RS11235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF977_RS11240	COG1070	Carbohydrate kinase
PF977_RS11245	COG2814	Major facilitator Superfamily
PF977_RS11260	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF977_RS11265	COG0300	oxidoreductase activity
PF977_RS11275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_RS11280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF977_RS11285	COG0583	DNA-binding transcription factor activity
PF977_RS11290	COG0070	glutamate synthase
PF977_RS11290	COG0069	glutamate synthase activity
PF977_RS11290	COG0067	glutamate synthase
PF977_RS11295	COG0493	'glutamate synthase
PF977_RS11300	COG0604	alcohol dehydrogenase
PF977_RS11305	COG0583	DNA-binding transcription factor activity
PF977_RS11310	COG0405	Gamma-glutamyltransferase
PF977_RS11315	COG0166	Belongs to the GPI family
PF977_RS11320	COG0582	viral genome integration into host DNA
PF977_RS11335	COG0534	Mate efflux family protein
PF977_RS11340	COG2017	converts alpha-aldose to the beta-anomer
PF977_RS11345	COG2027	D-alanyl-D-alanine carboxypeptidase
PF977_RS11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS11365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS11370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS11370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF977_RS11380	COG1649	PFAM Uncharacterised BCR, COG1649
PF977_RS11395	COG1960	acyl-CoA dehydrogenase activity
PF977_RS11400	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS11405	COG0439	Biotin carboxylase
PF977_RS11410	COG0511	ligase activity, forming carbon-carbon bonds
PF977_RS11415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF977_RS11420	COG1024	Enoyl-CoA hydratase
PF977_RS11425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF977_RS11430	COG2404	hydrolase activity, acting on ester bonds
PF977_RS11435	COG0586	Pfam SNARE associated Golgi protein
PF977_RS11440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_RS11445	COG2246	polysaccharide biosynthetic process
PF977_RS11450	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_RS11455	COG5520	Belongs to the glycosyl hydrolase 30 family
PF977_RS11470	COG1115	amino acid carrier protein
PF977_RS11485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF977_RS11490	COG0187	DNA topoisomerase II activity
PF977_RS11495	COG1832	CoA-binding protein
PF977_RS11500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PF977_RS11505	COG4841	protein insertion into membrane
PF977_RS11515	COG0824	Thioesterase
PF977_RS11535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS11540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF977_RS11555	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_RS11565	COG4846	Membrane protein involved in cytochrome C biogenesis
PF977_RS11570	COG2201	protein-glutamate methylesterase activity
PF977_RS11575	COG0785	Cytochrome C biogenesis protein
PF977_RS11585	COG3763	UPF0154 protein
PF977_RS11595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF977_RS11600	COG4224	UPF0291 protein
PF977_RS11605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF977_RS11610	COG1388	LysM domain
PF977_RS11615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF977_RS11635	COG4195	phage-related replication protein
PF977_RS11670	COG0697	spore germination
PF977_RS11685	COG3832	glyoxalase III activity
PF977_RS11700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_RS11740	COG0756	dUTP diphosphatase activity
PF977_RS11750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF977_RS11755	COG2814	Major facilitator Superfamily
PF977_RS11760	COG1525	nuclease
PF977_RS11770	COG1070	Carbohydrate kinase
PF977_RS11775	COG2115	Belongs to the xylose isomerase family
PF977_RS11780	COG1940	carbohydrate kinase activity
PF977_RS11785	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_RS11790	COG2211	Major facilitator Superfamily
PF977_RS11805	COG0135	phosphoribosylanthranilate isomerase activity
PF977_RS11820	COG3655	Transcriptional regulator
PF977_RS11835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS11855	COG0463	Glycosyl transferase, family 2
PF977_RS11900	COG1388	LysM domain
PF977_RS11900	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS11900	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS11905	COG4824	toxin secretion phage lysis holin
PF977_RS11925	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_RS11940	COG3953	SLT domain
PF977_RS11940	COG5412	phage tail tape measure protein
PF977_RS12100	COG3645	SOS response
PF977_RS12100	COG3646	Phage regulatory protein
PF977_RS12120	COG4974	Belongs to the 'phage' integrase family
PF977_RS12125	COG0174	glutamine synthetase
PF977_RS12130	COG0789	Transcriptional regulator
PF977_RS12135	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PF977_RS12140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF977_RS12160	COG3331	DNA recombination
PF977_RS12210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF977_RS12240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_RS12245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF977_RS12270	COG0756	dUTP diphosphatase activity
PF977_RS12275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS12310	COG1780	Probably involved in ribonucleotide reductase function
PF977_RS12395	COG0270	DNA (cytosine-5-)-methyltransferase activity
PF977_RS12410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF977_RS12435	COG3584	3D domain protein
PF977_RS12440	COG0587	DNA-directed DNA polymerase activity
PF977_RS12445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF977_RS12450	COG0358	DNA primase activity
PF977_RS12455	COG0305	Participates in initiation and elongation during chromosome replication
PF977_RS12465	COG2887	Belongs to the helicase family. UvrD subfamily
PF977_RS12510	COG2135	peptidase activity
PF977_RS12515	COG1793	dna ligase
PF977_RS12525	COG5484	DNA packaging
PF977_RS12525	COG3728	DNA packaging
PF977_RS12655	COG3655	Transcriptional regulator
PF977_RS12670	COG0582	viral genome integration into host DNA
PF977_RS12760	COG3655	Transcriptional regulator
PF977_RS12830	COG1395	domain, Protein
PF977_RS12845	COG0776	regulation of translation
PF977_RS12970	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_RS12985	COG0582	viral genome integration into host DNA
PF977_RS13025	COG0739	heme binding
PF977_RS13025	COG0741	lytic transglycosylase activity
PF977_RS13025	COG1196	nuclear chromosome segregation
PF977_RS13035	COG2433	Pfam Transposase IS66
PF977_RS13045	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_RS13050	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS13050	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS13065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF977_RS13070	COG0463	Glycosyl transferase, family 2
PF977_RS13075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS13080	COG3271	cysteine-type peptidase activity
PF977_RS13080	COG2274	protein secretion by the type I secretion system
PF977_RS13095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_RS13115	COG0457	Tetratricopeptide repeat
PF977_RS13135	COG5444	nuclease activity
PF977_RS13140	COG4282	regulation of fungal-type cell wall biogenesis
PF977_RS13150	COG1525	nuclease
PF977_RS13170	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS13175	COG4112	unkown
PF977_RS13180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF977_RS13185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF977_RS13190	COG1780	Probably involved in ribonucleotide reductase function
PF977_RS13205	COG1923	regulation of RNA biosynthetic process
PF977_RS13210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PF977_RS13225	COG2076	Multidrug Resistance protein
PF977_RS13230	COG2076	Multidrug Resistance protein
PF977_RS13235	COG1764	response to oxidative stress
PF977_RS13240	COG4195	phage-related replication protein
PF977_RS13250	COG1404	Belongs to the peptidase S8 family
PF977_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS13265	COG2124	cytochrome p450
PF977_RS13270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_RS13270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF977_RS13270	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF977_RS13270	COG3321	synthase
PF977_RS13275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS13275	COG3321	synthase
PF977_RS13275	COG4221	oxidoreductase activity
PF977_RS13280	COG3321	synthase
PF977_RS13280	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS13280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_RS13280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS13280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS13285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_RS13285	COG0300	oxidoreductase activity
PF977_RS13285	COG3321	synthase
PF977_RS13285	COG4221	oxidoreductase activity
PF977_RS13290	COG0300	oxidoreductase activity
PF977_RS13290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS13290	COG3321	synthase
PF977_RS13290	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS13295	COG1024	Enoyl-CoA hydratase
PF977_RS13300	COG1024	Enoyl-CoA hydratase
PF977_RS13305	COG3425	synthase
PF977_RS13310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF977_RS13315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_RS13320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_RS13320	COG2070	2-Nitropropane dioxygenase
PF977_RS13325	COG3321	synthase
PF977_RS13330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_RS13340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS13345	COG3226	Transcriptional regulator
PF977_RS13360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF977_RS13365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PF977_RS13375	COG4550	Control of competence regulator ComK, YlbF/YmcA
PF977_RS13380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF977_RS13385	COG0156	8-amino-7-oxononanoate synthase activity
PF977_RS13390	COG1063	alcohol dehydrogenase
PF977_RS13395	COG2359	stage V sporulation protein S
PF977_RS13400	COG1692	metallophosphoesterase
PF977_RS13405	COG1418	mRNA catabolic process
PF977_RS13410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_RS13415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PF977_RS13420	COG1546	Belongs to the CinA family
PF977_RS13420	COG1058	Belongs to the CinA family
PF977_RS13425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF977_RS13430	COG1426	Protein conserved in bacteria
PF977_RS13445	COG0300	oxidoreductase activity
PF977_RS13450	COG0612	Peptidase, M16
PF977_RS13455	COG0612	Peptidase, M16
PF977_RS13460	COG2814	Major facilitator Superfamily
PF977_RS13465	COG2188	Transcriptional regulator
PF977_RS13470	COG1674	ftsk spoiiie
PF977_RS13470	COG4980	gas vesicle protein
PF977_RS13480	COG0740	serine-type endopeptidase activity
PF977_RS13485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF977_RS13490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF977_RS13495	COG0527	aspartate kinase activity
PF977_RS13500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PF977_RS13505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF977_RS13510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF977_RS13515	COG1873	PFAM PRC-barrel domain
PF977_RS13520	COG0612	Peptidase, M16
PF977_RS13525	COG0726	polysaccharide deacetylase
PF977_RS13530	COG1185	polyribonucleotide nucleotidyltransferase activity
PF977_RS13535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PF977_RS13540	COG0196	riboflavin kinase activity
PF977_RS13545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF977_RS13550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PF977_RS13555	COG1550	Protein conserved in bacteria
PF977_RS13560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PF977_RS13565	COG1358	cellular component organization or biogenesis
PF977_RS13570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
PF977_RS13575	COG0195	Participates in both transcription termination and antitermination
PF977_RS13580	COG0779	Required for maturation of 30S ribosomal subunits
PF977_RS13585	COG2176	DNA-directed DNA polymerase activity
PF977_RS13590	COG0442	prolyl-tRNA aminoacylation
PF977_RS13595	COG0750	zinc metalloprotease
PF977_RS13600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PF977_RS13605	COG4589	Belongs to the CDS family
PF977_RS13610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF977_RS13615	COG0233	cytoplasmic translational termination
PF977_RS13620	COG0528	UMP kinase activity
PF977_RS13625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PF977_RS13630	COG0052	Belongs to the universal ribosomal protein uS2 family
PF977_RS13640	COG1191	sigma factor activity
PF977_RS13645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PF977_RS13650	COG1776	CheC inhibitor of MCP methylation
PF977_RS13655	COG0835	chemotaxis
PF977_RS13660	COG2198	Histidine kinase
PF977_RS13660	COG0643	Histidine kinase
PF977_RS13665	COG2201	protein-glutamate methylesterase activity
PF977_RS13670	COG0455	bacterial-type flagellum organization
PF977_RS13675	COG1419	protein localization to endoplasmic reticulum
PF977_RS13680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF977_RS13685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF977_RS13690	COG1684	flagellar biosynthetic protein fliR
PF977_RS13695	COG1987	bacterial-type flagellum assembly
PF977_RS13700	COG1338	Plays a role in the flagellum-specific transport system
PF977_RS13705	COG3190	flagellar
PF977_RS13710	COG2201	protein-glutamate methylesterase activity
PF977_RS13715	COG1776	CheC inhibitor of MCP methylation
PF977_RS13715	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_RS13720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_RS13725	COG1580	Controls the rotational direction of flagella during chemotaxis
PF977_RS13730	COG1582	Flagellar protein (FlbD)
PF977_RS13735	COG4786	Flagellar basal body rod
PF977_RS13740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PF977_RS13745	COG3144	bacterial-type flagellum assembly
PF977_RS13750	COG3334	PFAM MgtE intracellular
PF977_RS13755	COG2882	bacterial-type flagellum organization
PF977_RS13760	COG1157	protein secretion by the type III secretion system
PF977_RS13765	COG1317	bacterial-type flagellum organization
PF977_RS13770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_RS13775	COG1766	The M ring may be actively involved in energy transduction
PF977_RS13780	COG1677	Flagellar hook-basal body complex protein FliE
PF977_RS13785	COG1558	bacterial-type flagellum-dependent cell motility
PF977_RS13790	COG1815	bacterial-type flagellum-dependent cell motility
PF977_RS13795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF977_RS13800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PF977_RS13805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PF977_RS13810	COG4974	Belongs to the 'phage' integrase family
PF977_RS13815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PF977_RS13820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF977_RS13825	COG0758	DNA mediated transformation
PF977_RS13830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PF977_RS13835	COG0045	succinate-CoA ligase (ADP-forming) activity
PF977_RS13840	COG2257	FlhB HrpN YscU SpaS Family
PF977_RS13850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF977_RS13855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF977_RS13860	COG0335	large ribosomal subunit rRNA binding
PF977_RS13865	COG0336	Belongs to the RNA methyltransferase TrmD family
PF977_RS13870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF977_RS13880	COG1837	Belongs to the UPF0109 family
PF977_RS13885	COG0228	four-way junction DNA binding
PF977_RS13890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF977_RS13895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PF977_RS13905	COG0552	protein localization to endoplasmic reticulum
PF977_RS13910	COG1196	nuclear chromosome segregation
PF977_RS13915	COG0571	ribonuclease III activity
PF977_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS13930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_RS13935	COG0416	fatty acid biosynthetic process
PF977_RS13940	COG2050	protein possibly involved in aromatic compounds catabolism
PF977_RS13940	COG1349	DNA-binding transcription factor activity
PF977_RS13945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF977_RS13950	COG1760	l-serine dehydratase
PF977_RS13955	COG1760	l-serine dehydratase
PF977_RS13960	COG1461	Dihydroxyacetone kinase
PF977_RS13965	COG1302	Protein conserved in bacteria
PF977_RS13970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PF977_RS13980	COG1564	THIamine pyrophosphokinase
PF977_RS13985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF977_RS13990	COG1162	GTPase activity
PF977_RS13995	COG2815	serine threonine protein kinase
PF977_RS13995	COG0515	serine threonine protein kinase
PF977_RS14000	COG0631	protein serine/threonine phosphatase activity
PF977_RS14005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PF977_RS14010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PF977_RS14010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF977_RS14015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PF977_RS14020	COG0242	peptide deformylase activity
PF977_RS14025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF977_RS14030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF977_RS14035	COG1758	RNA polymerase activity
PF977_RS14040	COG0194	GDP metabolic process
PF977_RS14050	COG1561	YicC-like family, N-terminal region
PF977_RS14055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF977_RS14060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
PF977_RS14065	COG1648	precorrin-2 dehydrogenase activity
PF977_RS14070	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
PF977_RS14075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF977_RS14080	COG0529	Catalyzes the synthesis of activated sulfate
PF977_RS14085	COG2046	Belongs to the sulfate adenylyltransferase family
PF977_RS14090	COG0306	phosphate transporter
PF977_RS14095	COG0175	sulfate reduction
PF977_RS14100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PF977_RS14105	COG0284	orotidine-5'-phosphate decarboxylase activity
PF977_RS14110	COG0167	dihydroorotate dehydrogenase activity
PF977_RS14115	COG0543	2 iron, 2 sulfur cluster binding
PF977_RS14120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF977_RS14125	COG0505	Belongs to the CarA family
PF977_RS14130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF977_RS14135	COG0540	Belongs to the ATCase OTCase family
PF977_RS14140	COG2233	PERMEase
PF977_RS14145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PF977_RS14150	COG0564	pseudouridine synthase activity
PF977_RS14155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PF977_RS14160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_RS14165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF977_RS14170	COG3599	regulation of cell shape
PF977_RS14175	COG2302	S4 RNA-binding domain
PF977_RS14180	COG0762	integral membrane protein
PF977_RS14185	COG1799	cell septum assembly
PF977_RS14190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PF977_RS14195	COG1496	oxidoreductase activity
PF977_RS14200	COG1873	PFAM PRC-barrel domain
PF977_RS14205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_RS14210	COG1119	ATPase activity
PF977_RS14215	COG1191	sigma factor activity
PF977_RS14220	COG1191	sigma factor activity
PF977_RS14230	COG4412	M6 family metalloprotease domain protein
PF977_RS14230	COG1404	Belongs to the peptidase S8 family
PF977_RS14235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF977_RS14240	COG0849	cell division
PF977_RS14245	COG3856	small basic protein
PF977_RS14250	COG3879	Bacterial protein of unknown function (DUF881)
PF977_RS14255	COG3879	Bacterial protein of unknown function (DUF881)
PF977_RS14260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF977_RS14265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PF977_RS14270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_RS14275	COG0772	Belongs to the SEDS family
PF977_RS14280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF977_RS14285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF977_RS14290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF977_RS14295	COG0768	penicillin binding
PF977_RS14300	COG0768	penicillin binding
PF977_RS14305	COG4839	cell division protein FtsL
PF977_RS14310	COG0275	rRNA processing
PF977_RS14315	COG2001	Belongs to the MraZ family
PF977_RS14320	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PF977_RS14325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF977_RS14330	COG0454	-acetyltransferase
PF977_RS14345	COG1399	metal-binding, possibly nucleic acid-binding protein
PF977_RS14355	COG1323	Belongs to the UPF0348 family
PF977_RS14360	COG3480	Lon protease (S16) C-terminal proteolytic domain
PF977_RS14365	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF977_RS14370	COG3314	Sporulation integral membrane protein YlbJ
PF977_RS14375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PF977_RS14380	COG0742	ribosomal rna small subunit methyltransferase
PF977_RS14385	COG4471	UPF0298 protein
PF977_RS14390	COG3679	Belongs to the UPF0342 family
PF977_RS14405	COG2340	Cysteine-rich secretory protein family
PF977_RS14410	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PF977_RS14420	COG3336	cytochrome c oxidase
PF977_RS14425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF977_RS14430	COG1845	cytochrome c oxidase, subunit III
PF977_RS14435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF977_RS14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF977_RS14440	COG2010	Cytochrome c
PF977_RS14445	COG0109	protoheme IX farnesyltransferase activity
PF977_RS14450	COG1612	heme a metabolic process
PF977_RS14455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PF977_RS14460	COG0772	Belongs to the SEDS family
PF977_RS14465	COG4838	Belongs to the UPF0358 family
PF977_RS14470	COG2066	Belongs to the glutaminase family
PF977_RS14475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF977_RS14480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PF977_RS14490	COG4896	Protein conserved in bacteria
PF977_RS14500	COG1217	gtp-binding protein TYPA
PF977_RS14540	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF977_RS14550	COG0483	inositol monophosphate 1-phosphatase activity
PF977_RS14560	COG4493	Belongs to the UPF0637 family
PF977_RS14565	COG4476	Belongs to the UPF0223 family
PF977_RS14570	COG1982	Orn Lys Arg decarboxylase major
PF977_RS14580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS14585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_RS14590	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_RS14595	COG0022	dehydrogenase e1 component
PF977_RS14600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_RS14605	COG0497	DNA recombination
PF977_RS14615	COG0242	peptide deformylase activity
PF977_RS14620	COG0561	phosphatase activity
PF977_RS14625	COG5503	Protein of unknown function (DUF1447)
PF977_RS14630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF977_RS14635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF977_RS14640	COG0569	domain protein
PF977_RS14645	COG2105	PFAM AIG2 family protein
PF977_RS14645	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
PF977_RS14650	COG3852	Histidine kinase
PF977_RS14655	COG2002	toxin-antitoxin pair type II binding
PF977_RS14660	COG1077	Cell shape determining protein MreB Mrl
PF977_RS14670	COG2309	aminopeptidase activity
PF977_RS14675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF977_RS14680	COG0488	(ABC) transporter
PF977_RS14690	COG0681	Belongs to the peptidase S26 family
PF977_RS14695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_RS14695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS14695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_RS14700	COG1105	Belongs to the carbohydrate kinase PfkB family
PF977_RS14705	COG1349	DNA-binding transcription factor activity
PF977_RS14710	COG0577	efflux transmembrane transporter activity
PF977_RS14715	COG1136	(ABC) transporter
PF977_RS14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF977_RS14730	COG1132	(ABC) transporter
PF977_RS14735	COG1132	(ABC) transporter
PF977_RS14740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PF977_RS14745	COG0314	molybdopterin synthase activity
PF977_RS14750	COG1763	Mo-molybdopterin cofactor biosynthetic process
PF977_RS14755	COG0303	'Molybdopterin
PF977_RS14760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF977_RS14765	COG0746	molybdenum cofactor guanylyltransferase activity
PF977_RS14780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS14785	COG0450	alkyl hydroperoxide reductase
PF977_RS14790	COG0668	transmembrane transport
PF977_RS14800	COG1473	amidohydrolase
PF977_RS14805	COG2171	N-acyltransferase activity
PF977_RS14810	COG0716	FMN binding
PF977_RS14820	COG0716	FMN binding
PF977_RS14825	COG0583	DNA-binding transcription factor activity
PF977_RS14830	COG0517	IMP dehydrogenase activity
PF977_RS14840	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
PF977_RS14845	COG4703	Protein of unknown function (DUF1797)
PF977_RS14850	COG2200	EAL domain
PF977_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS14860	COG1408	metallophosphoesterase
PF977_RS14865	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_RS14870	COG2814	Major facilitator Superfamily
PF977_RS14880	COG0835	chemotaxis
PF977_RS14880	COG0784	Response regulator, receiver
PF977_RS14890	COG0436	Aminotransferase
PF977_RS14895	COG4191	Histidine kinase
PF977_RS14900	COG0768	penicillin binding
PF977_RS14905	COG2340	Cysteine-rich secretory protein family
PF977_RS14910	COG2084	Dehydrogenase
PF977_RS14915	COG0840	transmembrane signaling receptor activity
PF977_RS14920	COG0456	acetyltransferase
PF977_RS14925	COG1533	DNA photolyase activity
PF977_RS14935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF977_RS14940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS14945	COG1263	PTS System
PF977_RS14945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS14945	COG2190	(PTS) system
PF977_RS14950	COG3711	transcriptional antiterminator
PF977_RS14955	COG1609	Transcriptional regulator
PF977_RS14960	COG0006	proline dipeptidase activity
PF977_RS14970	COG2217	Heavy metal translocating P-type atpase
PF977_RS14975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS14980	COG2244	polysaccharide biosynthetic process
PF977_RS14985	COG3773	Cell wall hydrolase
PF977_RS14995	COG4873	Protein conserved in bacteria
PF977_RS15005	COG3858	chitin binding
PF977_RS15010	COG1388	LysM domain
PF977_RS15015	COG4641	Protein conserved in bacteria
PF977_RS15015	COG1388	LysM domain
PF977_RS15020	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS15025	COG1733	regulation of RNA biosynthetic process
PF977_RS15030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PF977_RS15035	COG0602	queuosine metabolic process
PF977_RS15040	COG0720	synthase
PF977_RS15045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF977_RS15050	COG3949	Membrane
PF977_RS15055	COG0542	response to heat
PF977_RS15060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF977_RS15065	COG1360	Flagellar Motor Protein
PF977_RS15070	COG1846	Transcriptional regulator
PF977_RS15075	COG3852	Histidine kinase
PF977_RS15090	COG3339	Conserved Protein
PF977_RS15095	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PF977_RS15100	COG0235	Class ii aldolase
PF977_RS15105	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PF977_RS15110	COG1850	ribulose-bisphosphate carboxylase activity
PF977_RS15115	COG0436	Aminotransferase
PF977_RS15120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF977_RS15125	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PF977_RS15130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PF977_RS15140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF977_RS15145	COG5002	protein histidine kinase activity
PF977_RS15150	COG3594	Acyltransferase
PF977_RS15165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF977_RS15170	COG0501	Belongs to the peptidase M48B family
PF977_RS15190	COG1191	sigma factor activity
PF977_RS15195	COG0861	Integral membrane protein TerC family
PF977_RS15200	COG0586	Pfam SNARE associated Golgi protein
PF977_RS15205	COG3300	MHYT domain
PF977_RS15205	COG5001	Diguanylate cyclase
PF977_RS15210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PF977_RS15215	COG1793	dna ligase
PF977_RS15215	COG3285	dna ligase
PF977_RS15220	COG0463	Glycosyl transferase, family 2
PF977_RS15230	COG1408	metallophosphoesterase
PF977_RS15235	COG0726	polysaccharide deacetylase
PF977_RS15240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_RS15245	COG1846	Transcriptional regulator
PF977_RS15260	COG0789	Transcriptional regulator
PF977_RS15265	COG2239	Acts as a magnesium transporter
PF977_RS15280	COG3212	peptidase
PF977_RS15285	COG3212	peptidase
PF977_RS15290	COG3850	Histidine kinase
PF977_RS15290	COG5002	protein histidine kinase activity
PF977_RS15295	COG0745	RESPONSE REGULATOR receiver
PF977_RS15305	COG4721	ABC-type cobalt transport system, permease component
PF977_RS15310	COG1122	ATPase activity
PF977_RS15315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF977_RS15320	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS15325	COG1404	Belongs to the peptidase S8 family
PF977_RS15330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_RS15335	COG0590	tRNA wobble adenosine to inosine editing
PF977_RS15345	COG1764	response to oxidative stress
PF977_RS15350	COG1846	Transcriptional regulator
PF977_RS15355	COG1764	response to oxidative stress
PF977_RS15360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PF977_RS15365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF977_RS15370	COG0788	formyltetrahydrofolate deformylase activity
PF977_RS15375	COG2076	Multidrug Resistance protein
PF977_RS15380	COG2076	Multidrug Resistance protein
PF977_RS15385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS15390	COG2318	DinB family
PF977_RS15395	COG2323	membrane
PF977_RS15405	COG1017	nitric oxide dioxygenase activity
PF977_RS15405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF977_RS15410	COG1607	acyl-coa hydrolase
PF977_RS15415	COG1834	amidinotransferase
PF977_RS15420	COG2706	6-phosphogluconolactonase activity
PF977_RS15425	COG4608	Belongs to the ABC transporter superfamily
PF977_RS15430	COG0791	NLP P60 protein
PF977_RS15435	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_RS15440	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF977_RS15445	COG4166	transmembrane transport
PF977_RS15450	COG0444	Belongs to the ABC transporter superfamily
PF977_RS15455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_RS15460	COG0601	transmembrane transport
PF977_RS15465	COG2362	D-Aminopeptidase
PF977_RS15470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_RS15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_RS15485	COG0463	Glycosyl transferase, family 2
PF977_RS15490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF977_RS15500	COG0346	lactoylglutathione lyase activity
PF977_RS15505	COG0531	amino acid
PF977_RS15510	COG1392	Phosphate transport regulator
PF977_RS15515	COG0306	phosphate transporter
PF977_RS15535	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS15535	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS15575	COG3778	Protein conserved in bacteria
PF977_RS15580	COG3299	homolog of phage Mu protein gp47
PF977_RS15585	COG3628	GPW Gp25 family protein
PF977_RS15595	COG4193	domain, Protein
PF977_RS15600	COG1652	LysM domain
PF977_RS15605	COG3953	SLT domain
PF977_RS15605	COG5412	phage tail tape measure protein
PF977_RS15605	COG3953	SLT domain
PF977_RS15605	COG5412	phage tail tape measure protein
PF977_RS15655	COG4653	Phage capsid family
PF977_RS15660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PF977_RS15665	COG5518	Phage portal protein
PF977_RS15670	COG1783	phage Terminase large subunit
PF977_RS15675	COG3728	DNA packaging
PF977_RS15675	COG5484	DNA packaging
PF977_RS15680	COG1595	DNA-templated transcription, initiation
PF977_RS15700	COG1484	DNA-dependent DNA replication
PF977_RS15705	COG1522	sequence-specific DNA binding
PF977_RS15715	COG1396	sequence-specific DNA binding
PF977_RS15720	COG2856	Zn peptidase
PF977_RS15725	COG3546	catalase activity
PF977_RS15730	COG4195	phage-related replication protein
PF977_RS15740	COG1388	LysM domain
PF977_RS15740	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS15740	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS15745	COG2350	Protein conserved in bacteria
PF977_RS15755	COG0457	Tetratricopeptide repeat
PF977_RS15760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF977_RS15765	COG2318	DinB family
PF977_RS15770	COG0730	response to heat
PF977_RS15775	COG2721	sulfolactate sulfo-lyase activity
PF977_RS15780	COG0246	Mannitol dehydrogenase
PF977_RS15785	COG1609	Transcriptional regulator
PF977_RS15790	COG2271	Major facilitator Superfamily
PF977_RS15795	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS15800	COG1312	Catalyzes the dehydration of D-mannonate
PF977_RS15805	COG1063	alcohol dehydrogenase
PF977_RS15810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PF977_RS15815	COG2211	Major facilitator Superfamily
PF977_RS15820	COG1904	glucuronate isomerase
PF977_RS15825	COG1252	NADH dehydrogenase
PF977_RS15835	COG4297	protein containing double-stranded beta helix domain
PF977_RS15840	COG0697	spore germination
PF977_RS15845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_RS15850	COG0390	transport system, permease component
PF977_RS15855	COG1587	Uroporphyrinogen-III synthase
PF977_RS15865	COG1819	glycosyl
PF977_RS15870	COG2124	cytochrome p450
PF977_RS15880	COG1051	belongs to the nudix hydrolase family
PF977_RS15890	COG2427	Protein of unknown function (DUF1641)
PF977_RS15895	COG3383	formate dehydrogenase (NAD+) activity
PF977_RS15905	COG2205	protein histidine kinase activity
PF977_RS15910	COG5504	Zn-dependent protease
PF977_RS15925	COG0726	polysaccharide deacetylase
PF977_RS15935	COG0109	protoheme IX farnesyltransferase activity
PF977_RS15950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF977_RS15960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS15970	COG1482	cell wall glycoprotein biosynthetic process
PF977_RS15975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_RS15975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_RS15975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS15980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS15980	COG3711	transcriptional antiterminator
PF977_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS15995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF977_RS16045	COG5444	nuclease activity
PF977_RS16060	COG5505	Protein of unknown function (DUF819)
PF977_RS16065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS16070	COG0626	cystathionine gamma-synthase activity
PF977_RS16075	COG0626	cystathionine gamma-synthase activity
PF977_RS16080	COG2382	esterase
PF977_RS16085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF977_RS16090	COG2153	protein acetylation
PF977_RS16100	COG0210	DNA helicase
PF977_RS16155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PF977_RS16160	COG0351	phosphomethylpyrimidine kinase
PF977_RS16165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF977_RS16170	COG2022	thiamine diphosphate biosynthetic process
PF977_RS16175	COG2104	thiamine diphosphate biosynthetic process
PF977_RS16180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_RS16185	COG0352	thiamine-phosphate diphosphorylase activity
PF977_RS16190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF977_RS16195	COG0569	domain protein
PF977_RS16195	COG0475	glutathione-regulated potassium exporter activity
PF977_RS16200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF977_RS16205	COG0564	pseudouridine synthase activity
PF977_RS16210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF977_RS16215	COG2357	RelA SpoT domain protein
PF977_RS16225	COG4116	CYTH
PF977_RS16230	COG0741	lytic transglycosylase activity
PF977_RS16235	COG2346	COG2346, Truncated hemoglobins
PF977_RS16240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF977_RS16250	COG1164	Oligoendopeptidase f
PF977_RS16255	COG4469	Competence protein
PF977_RS16265	COG4862	establishment of competence for transformation
PF977_RS16275	COG0861	Integral membrane protein TerC family
PF977_RS16280	COG1393	Belongs to the ArsC family
PF977_RS16285	COG0456	acetyltransferase
PF977_RS16290	COG2814	Major facilitator Superfamily
PF977_RS16295	COG4608	Belongs to the ABC transporter superfamily
PF977_RS16300	COG0444	Belongs to the ABC transporter superfamily
PF977_RS16305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_RS16310	COG0601	transmembrane transport
PF977_RS16315	COG4166	transmembrane transport
PF977_RS16320	COG0180	Tryptophanyl-tRNA synthetase
PF977_RS16330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_RS16335	COG0601	transmembrane transport
PF977_RS16345	COG4608	Belongs to the ABC transporter superfamily
PF977_RS16350	COG0444	Belongs to the ABC transporter superfamily
PF977_RS16355	COG5504	Zn-dependent protease
PF977_RS16360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF977_RS16365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_RS16380	COG1744	ABC transporter substrate-binding protein PnrA-like
PF977_RS16390	COG2267	carboxylic ester hydrolase activity
PF977_RS16405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PF977_RS16410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF977_RS16415	COG0505	Belongs to the CarA family
PF977_RS16420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF977_RS16430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF977_RS16435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PF977_RS16440	COG2271	Major facilitator Superfamily
PF977_RS16445	COG0277	FAD linked oxidase domain protein
PF977_RS16455	COG2151	metal-sulfur cluster biosynthetic enzyme
PF977_RS16460	COG1073	alpha beta
PF977_RS16465	COG0561	phosphatase activity
PF977_RS16485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS16490	COG1307	EDD domain protein, DegV family
PF977_RS16495	COG3227	Zinc metalloprotease (Elastase)
PF977_RS16510	COG1695	Transcriptional regulator
PF977_RS16530	COG2996	Protein conserved in bacteria
PF977_RS16535	COG1666	GTP binding
PF977_RS16540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF977_RS16540	COG0646	methionine synthase
PF977_RS16545	COG2153	protein acetylation
PF977_RS16550	COG0454	-acetyltransferase
PF977_RS16555	COG2814	Major facilitator Superfamily
PF977_RS16560	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_RS16565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS16570	COG1809	phosphosulfolactate synthase activity
PF977_RS16575	COG2045	Belongs to the ComB family
PF977_RS16580	COG0175	sulfate reduction
PF977_RS16585	COG2046	Belongs to the sulfate adenylyltransferase family
PF977_RS16590	COG0529	Catalyzes the synthesis of activated sulfate
PF977_RS16595	COG2267	carboxylic ester hydrolase activity
PF977_RS16600	COG1357	PFAM Pentapeptide repeats (8 copies)
PF977_RS16605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS16615	COG2318	DinB family
PF977_RS16620	COG0673	inositol 2-dehydrogenase activity
PF977_RS16625	COG1609	Transcriptional regulator
PF977_RS16630	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS16630	COG2207	Transcriptional regulator
PF977_RS16635	COG0534	Mate efflux family protein
PF977_RS16640	COG1562	ergosterol biosynthetic process
PF977_RS16645	COG2318	DinB family
PF977_RS16650	COG0367	asparagine synthase
PF977_RS16660	COG1404	Belongs to the peptidase S8 family
PF977_RS16670	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF977_RS16675	COG5337	Spore coat protein CotH
PF977_RS16715	COG1403	HNH endonuclease
PF977_RS16720	COG0419	ATPase involved in DNA repair
PF977_RS16725	COG0420	3'-5' exonuclease activity
PF977_RS16730	COG1074	ATP-dependent DNA helicase activity
PF977_RS16735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PF977_RS16740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PF977_RS16750	COG4533	DNA binding
PF977_RS16755	COG2814	Major facilitator Superfamily
PF977_RS16755	COG0477	Major facilitator Superfamily
PF977_RS16760	COG3180	Ammonia monooxygenase
PF977_RS16765	COG1609	Transcriptional regulator
PF977_RS16770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_RS16775	COG0561	phosphatase activity
PF977_RS16780	COG0673	inositol 2-dehydrogenase activity
PF977_RS16785	COG0738	Major facilitator superfamily
PF977_RS16790	COG1846	Transcriptional regulator
PF977_RS16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF977_RS16800	COG0681	Belongs to the peptidase S26 family
PF977_RS16805	COG0398	Pfam SNARE associated Golgi protein
PF977_RS16820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS16835	COG4903	ComK protein
PF977_RS16845	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_RS16850	COG0723	plastoquinol--plastocyanin reductase activity
PF977_RS16855	COG0840	transmembrane signaling receptor activity
PF977_RS16860	COG1268	BioY protein
PF977_RS16865	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS16870	COG0183	Belongs to the thiolase family
PF977_RS16875	COG0406	alpha-ribazole phosphatase activity
PF977_RS16880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF977_RS16885	COG0604	alcohol dehydrogenase
PF977_RS16890	COG0456	acetyltransferase
PF977_RS16895	COG1404	Belongs to the peptidase S8 family
PF977_RS16900	COG0501	Belongs to the peptidase M48B family
PF977_RS16910	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS16915	COG0702	epimerase
PF977_RS16920	COG0095	Lipoate-protein ligase
PF977_RS16925	COG1234	tRNA 3'-trailer cleavage
PF977_RS16935	COG1301	dicarboxylic acid transport
PF977_RS16940	COG4405	Protein conserved in bacteria
PF977_RS16945	COG1363	Peptidase, m42
PF977_RS16955	COG4377	Putative membrane peptidase family (DUF2324)
PF977_RS16960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_RS16965	COG1511	domain protein
PF977_RS16970	COG1309	transcriptional regulator
PF977_RS16975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PF977_RS16980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PF977_RS16985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PF977_RS16990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_RS16995	COG2329	Antibiotic biosynthesis monooxygenase
PF977_RS17005	COG3069	C4-dicarboxylate transmembrane transporter activity
PF977_RS17010	COG1473	amidohydrolase
PF977_RS17020	COG4473	ABC transporter
PF977_RS17025	COG1131	(ABC) transporter
PF977_RS17030	COG0537	adenosine 5'-monophosphoramidase activity
PF977_RS17035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PF977_RS17050	COG4980	gas vesicle protein
PF977_RS17055	COG1846	Transcriptional regulator
PF977_RS17085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF977_RS17095	COG3481	metal-dependent phosphohydrolase, HD sub domain
PF977_RS17100	COG4717	serine-type aminopeptidase activity
PF977_RS17105	COG0420	3'-5' exonuclease activity
PF977_RS17110	COG1668	transmembrane transport
PF977_RS17115	COG4152	abc transporter atp-binding protein
PF977_RS17125	COG1024	Enoyl-CoA hydratase
PF977_RS17135	COG0490	domain, Protein
PF977_RS17140	COG0475	glutathione-regulated potassium exporter activity
PF977_RS17145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF977_RS17150	COG0561	phosphatase activity
PF977_RS17155	COG4335	DNA alkylation repair
PF977_RS17160	COG3679	Belongs to the UPF0342 family
PF977_RS17165	COG4399	Belongs to the UPF0754 family
PF977_RS17170	COG0189	ligase activity
PF977_RS17175	COG0189	ligase activity
PF977_RS17195	COG0702	epimerase
PF977_RS17200	COG1132	(ABC) transporter
PF977_RS17205	COG1132	(ABC) transporter
PF977_RS17215	COG0589	response to stress
PF977_RS17220	COG1757	Na H antiporter
PF977_RS17225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_RS17230	COG0726	polysaccharide deacetylase
PF977_RS17235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF977_RS17240	COG0668	transmembrane transport
PF977_RS17250	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_RS17255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF977_RS17260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF977_RS17265	COG1253	flavin adenine dinucleotide binding
PF977_RS17270	COG0436	Aminotransferase
PF977_RS17275	COG0789	Transcriptional regulator
PF977_RS17280	COG1253	flavin adenine dinucleotide binding
PF977_RS17285	COG0204	Acyl-transferase
PF977_RS17290	COG0667	Aldo Keto reductase
PF977_RS17295	COG1595	DNA-templated transcription, initiation
PF977_RS17310	COG0456	acetyltransferase
PF977_RS17315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS17320	COG0733	neurotransmitter:sodium symporter activity
PF977_RS17325	COG0531	amino acid
PF977_RS17330	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS17335	COG0372	Belongs to the citrate synthase family
PF977_RS17340	COG0583	DNA-binding transcription factor activity
PF977_RS17345	COG1388	LysM domain
PF977_RS17345	COG0791	NLP P60 protein
PF977_RS17350	COG1785	Belongs to the alkaline phosphatase family
PF977_RS17355	COG2719	SpoVR family
PF977_RS17360	COG0668	transmembrane transport
PF977_RS17365	COG1959	2 iron, 2 sulfur cluster binding
PF977_RS17370	COG0791	NLP P60 protein
PF977_RS17370	COG1388	LysM domain
PF977_RS17385	COG0431	NADPH-dependent FMN reductase
PF977_RS17390	COG2197	response regulator
PF977_RS17395	COG2203	Gaf domain
PF977_RS17395	COG4585	Histidine kinase
PF977_RS17400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF977_RS17405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PF977_RS17410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF977_RS17415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF977_RS17420	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PF977_RS17425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_RS17430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF977_RS17430	COG3153	acetyltransferase
PF977_RS17435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF977_RS17440	COG0517	IMP dehydrogenase activity
PF977_RS17450	COG0564	pseudouridine synthase activity
PF977_RS17455	COG3764	Sortase (surface protein transpeptidase)
PF977_RS17460	COG4085	toxin activity
PF977_RS17460	COG1525	nuclease
PF977_RS17460	COG0737	Belongs to the 5'-nucleotidase family
PF977_RS17465	COG5577	PFAM Coat F domain
PF977_RS17485	COG1823	symporter activity
PF977_RS17490	COG3706	GGDEF domain
PF977_RS17495	COG1464	Belongs to the NlpA lipoprotein family
PF977_RS17500	COG1278	Cold shock
PF977_RS17505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_RS17510	COG1131	(ABC) transporter
PF977_RS17515	COG1131	(ABC) transporter
PF977_RS17520	COG1725	Transcriptional regulator
PF977_RS17540	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF977_RS17545	COG2814	Major facilitator Superfamily
PF977_RS17550	COG1566	PFAM secretion protein HlyD family protein
PF977_RS17555	COG1846	Transcriptional regulator
PF977_RS17560	COG2718	Belongs to the UPF0229 family
PF977_RS17565	COG2766	serine protein kinase
PF977_RS17570	COG1664	Polymer-forming cytoskeletal
PF977_RS17575	COG1664	Polymer-forming cytoskeletal
PF977_RS17580	COG0789	Transcriptional regulator
PF977_RS17585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF977_RS17595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF977_RS17600	COG3382	B3 4 domain protein
PF977_RS17610	COG1476	TRANSCRIPTIONal
PF977_RS17620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PF977_RS17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS17635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF977_RS17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF977_RS17645	COG1116	anion transmembrane transporter activity
PF977_RS17650	COG0753	catalase activity
PF977_RS17660	COG0277	FAD linked oxidase domain protein
PF977_RS17665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PF977_RS17670	COG3340	Belongs to the peptidase S51 family
PF977_RS17675	COG5577	PFAM Coat F domain
PF977_RS17685	COG4326	sporulation control protein
PF977_RS17795	COG0735	belongs to the Fur family
PF977_RS17800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF977_RS17805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PF977_RS17810	COG4129	membrane
PF977_RS17815	COG1132	(ABC) transporter
PF977_RS17820	COG3557	Belongs to the UPF0374 family
PF977_RS17835	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS17845	COG1194	a g-specific adenine glycosylase
PF977_RS17850	COG1988	membrane-bound metal-dependent
PF977_RS17855	COG4485	Bacterial membrane protein, YfhO
PF977_RS17860	COG0463	Glycosyl transferase, family 2
PF977_RS17865	COG0596	Alpha beta hydrolase
PF977_RS17870	COG5658	integral membrane protein
PF977_RS17875	COG3103	Sh3 type 3 domain protein
PF977_RS17890	COG2814	Major facilitator Superfamily
PF977_RS17900	COG2137	regulation of response to DNA damage stimulus
PF977_RS17905	COG1090	epimerase
PF977_RS17920	COG0778	Nitroreductase
PF977_RS17925	COG0384	phenazine biosynthesis protein PhzF
PF977_RS17930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS17940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS17945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PF977_RS17945	COG0392	lysyltransferase activity
PF977_RS17950	COG1846	Transcriptional regulator
PF977_RS17955	COG2814	Major facilitator Superfamily
PF977_RS17960	COG2318	DinB family
PF977_RS17965	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
PF977_RS17970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PF977_RS17975	COG1695	Transcriptional regulator
PF977_RS17980	COG0842	Transport permease protein
PF977_RS17985	COG0842	Transport permease protein
PF977_RS17985	COG1511	domain protein
PF977_RS17990	COG1131	(ABC) transporter
PF977_RS17995	COG2197	response regulator
PF977_RS18000	COG4585	Histidine kinase
PF977_RS18005	COG2514	catechol 2,3-dioxygenase activity
PF977_RS18010	COG2259	Doxx family
PF977_RS18015	COG1132	(ABC) transporter
PF977_RS18020	COG1132	(ABC) transporter
PF977_RS18025	COG1263	PTS System
PF977_RS18025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS18030	COG1737	Transcriptional regulator
PF977_RS18035	COG1486	melibiose metabolic process
PF977_RS18040	COG4842	Belongs to the WXG100 family
PF977_RS18060	COG1742	UPF0060 membrane protein
PF977_RS18070	COG3284	Transcriptional regulator
PF977_RS18075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_RS18080	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_RS18085	COG0022	dehydrogenase e1 component
PF977_RS18090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_RS18100	COG4637	Psort location Cytoplasmic, score
PF977_RS18105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF977_RS18115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF977_RS18120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF977_RS18125	COG0598	Magnesium transport protein CorA
PF977_RS18130	COG2084	Dehydrogenase
PF977_RS18135	COG0726	polysaccharide deacetylase
PF977_RS18145	COG0535	radical SAM domain protein
PF977_RS18150	COG0668	transmembrane transport
PF977_RS18160	COG0387	Pfam Sodium calcium exchanger
PF977_RS18165	COG0477	Major facilitator Superfamily
PF977_RS18170	COG1295	ribonuclease BN
PF977_RS18175	COG4980	gas vesicle protein
PF977_RS18180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_RS18185	COG4840	Belongs to the UPF0435 family
PF977_RS18190	COG2814	Major facilitator Superfamily
PF977_RS18195	COG0693	protein deglycase activity
PF977_RS18200	COG0737	Belongs to the 5'-nucleotidase family
PF977_RS18205	COG0778	Nitroreductase
PF977_RS18210	COG2188	Transcriptional regulator
PF977_RS18215	COG0366	Alpha amylase catalytic
PF977_RS18220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS18220	COG1263	PTS System
PF977_RS18225	COG0697	spore germination
PF977_RS18240	COG0531	amino acid
PF977_RS18245	COG1115	amino acid carrier protein
PF977_RS18260	COG1368	sulfuric ester hydrolase activity
PF977_RS18265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS18265	COG1263	PTS System
PF977_RS18270	COG0024	Methionine aminopeptidase
PF977_RS18290	COG2258	MOSC domain
PF977_RS18295	COG1254	Belongs to the acylphosphatase family
PF977_RS18300	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PF977_RS18305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_RS18310	COG2851	Citrate transporter
PF977_RS18320	COG3181	Tripartite tricarboxylate transporter family receptor
PF977_RS18325	COG4565	transcriptional regulatory protein
PF977_RS18330	COG3290	protein histidine kinase activity
PF977_RS18335	COG0471	metal ion transport
PF977_RS18340	COG3866	Pectate lyase
PF977_RS18355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF977_RS18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS18365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS18370	COG1120	ATPase activity
PF977_RS18375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF977_RS18380	COG2211	Major facilitator Superfamily
PF977_RS18385	COG2130	NADP-dependent
PF977_RS18390	COG0456	acetyltransferase
PF977_RS18395	COG0513	Belongs to the DEAD box helicase family
PF977_RS18400	COG0488	(ABC) transporter
PF977_RS18410	COG2814	Major facilitator Superfamily
PF977_RS18415	COG0789	Transcriptional regulator
PF977_RS18425	COG0488	(ABC) transporter
PF977_RS18430	COG0840	transmembrane signaling receptor activity
PF977_RS18435	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS18440	COG0531	amino acid
PF977_RS18445	COG1011	Hydrolase
PF977_RS18450	COG2223	nitrite transmembrane transporter activity
PF977_RS18455	COG1442	glycosyl transferase family 8
PF977_RS18460	COG1216	Glycosyl transferase, family 2
PF977_RS18465	COG1442	glycosyl transferase family 8
PF977_RS18470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_RS18475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF977_RS18480	COG1368	sulfuric ester hydrolase activity
PF977_RS18485	COG2124	cytochrome p450
PF977_RS18485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_RS18500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF977_RS18505	COG1846	Transcriptional regulator
PF977_RS18510	COG0697	spore germination
PF977_RS18515	COG0670	Belongs to the BI1 family
PF977_RS18520	COG5583	Uncharacterized small protein (DUF2292)
PF977_RS18535	COG0346	lactoylglutathione lyase activity
PF977_RS18540	COG2329	Antibiotic biosynthesis monooxygenase
PF977_RS18545	COG2323	membrane
PF977_RS18550	COG1486	melibiose metabolic process
PF977_RS18555	COG0395	ABC-type sugar transport system, permease component
PF977_RS18560	COG4209	transmembrane transport
PF977_RS18565	COG1653	transport
PF977_RS18575	COG1874	Beta-galactosidase
PF977_RS18580	COG2755	lipolytic protein G-D-S-L family
PF977_RS18585	COG3401	FG-GAP repeat protein
PF977_RS18590	COG3401	FG-GAP repeat protein
PF977_RS18595	COG5578	integral membrane protein
PF977_RS18605	COG2755	lipolytic protein G-D-S-L family
PF977_RS18610	COG2207	Transcriptional regulator
PF977_RS18615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PF977_RS18620	COG0395	ABC-type sugar transport system, permease component
PF977_RS18625	COG1175	transmembrane transport
PF977_RS18630	COG1653	transport
PF977_RS18635	COG2207	Transcriptional regulator
PF977_RS18635	COG4753	response regulator
PF977_RS18640	COG2972	Histidine kinase
PF977_RS18645	COG5578	integral membrane protein
PF977_RS18655	COG0454	-acetyltransferase
PF977_RS18660	COG3546	catalase activity
PF977_RS18680	COG3631	Ketosteroid isomerase-related protein
PF977_RS18685	COG1309	transcriptional regulator
PF977_RS18695	COG0217	transcriptional regulatory protein
PF977_RS18705	COG0457	Tetratricopeptide repeat
PF977_RS18715	COG3391	amine dehydrogenase activity
PF977_RS18720	COG5444	nuclease activity
PF977_RS18735	COG0457	Tetratricopeptide repeat
PF977_RS18745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF977_RS18750	COG1597	lipid kinase activity
PF977_RS18755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF977_RS18765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF977_RS18770	COG0154	amidase activity
PF977_RS18775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF977_RS18780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_RS18785	COG1285	pathogenesis
PF977_RS18790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_RS18795	COG4851	CamS sex pheromone cAM373 precursor
PF977_RS18800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PF977_RS18805	COG0210	DNA helicase
PF977_RS18810	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PF977_RS18815	COG0069	glutamate synthase activity
PF977_RS18820	COG4496	protein, YerC YecD
PF977_RS18825	COG1470	cell adhesion involved in biofilm formation
PF977_RS18830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF977_RS18840	COG0531	amino acid
PF977_RS18845	COG1522	sequence-specific DNA binding
PF977_RS18850	COG0151	Belongs to the GarS family
PF977_RS18855	COG0138	bifunctional purine biosynthesis protein purh
PF977_RS18860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF977_RS18865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PF977_RS18870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PF977_RS18875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF977_RS18880	COG0047	phosphoribosylformylglycinamidine synthase activity
PF977_RS18885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF977_RS18890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PF977_RS18895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF977_RS18900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF977_RS18905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PF977_RS18915	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
PF977_RS18925	COG3064	Membrane
PF977_RS18930	COG2252	PERMEase
PF977_RS18945	COG0519	Catalyzes the synthesis of GMP from XMP
PF977_RS18945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF977_RS18950	COG1305	Transglutaminase-like
PF977_RS18955	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PF977_RS18960	COG0714	Associated with various cellular activities
PF977_RS18965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_RS18975	COG1113	amino acid transport
PF977_RS18980	COG2132	Multicopper oxidase
PF977_RS18990	COG2267	carboxylic ester hydrolase activity
PF977_RS19005	COG0823	Involved in the tonB-independent uptake of proteins
PF977_RS19010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF977_RS19015	COG1063	alcohol dehydrogenase
PF977_RS19020	COG2814	Major facilitator Superfamily
PF977_RS19030	COG4260	virion core protein, lumpy skin disease virus
PF977_RS19035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF977_RS19040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF977_RS19045	COG1842	Phage shock protein A
PF977_RS19050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_RS19055	COG2211	Major facilitator Superfamily
PF977_RS19060	COG1063	alcohol dehydrogenase
PF977_RS19065	COG0457	Tetratricopeptide repeat
PF977_RS19070	COG1073	alpha beta
PF977_RS19115	COG3409	Peptidoglycan-binding domain 1 protein
PF977_RS19115	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_RS19180	COG0791	NLP P60 protein
PF977_RS19180	COG1388	LysM domain
PF977_RS19185	COG5280	Phage tail tape measure protein TP901
PF977_RS19185	COG3953	SLT domain
PF977_RS19255	COG5484	DNA packaging
PF977_RS19280	COG1595	DNA-templated transcription, initiation
PF977_RS19350	COG1484	DNA-dependent DNA replication
PF977_RS19355	COG3935	DnaD domain protein
PF977_RS19405	COG1396	sequence-specific DNA binding
PF977_RS19415	COG2856	Zn peptidase
PF977_RS19420	COG4974	Belongs to the 'phage' integrase family
PF977_RS19425	COG0459	protein refolding
PF977_RS19435	COG1266	CAAX protease self-immunity
PF977_RS19445	COG0805	protein transport
PF977_RS19450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_RS19455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PF977_RS19460	COG0315	cyclic pyranopterin monophosphate synthase activity
PF977_RS19465	COG0488	(ABC) transporter
PF977_RS19470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PF977_RS19475	COG0456	acetyltransferase
PF977_RS19480	COG1214	PFAM Peptidase M22, glycoprotease
PF977_RS19485	COG0802	atpase or kinase
PF977_RS19490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF977_RS19535	COG4124	Belongs to the glycosyl hydrolase 26 family
PF977_RS19540	COG1482	cell wall glycoprotein biosynthetic process
PF977_RS19545	COG1940	carbohydrate kinase activity
PF977_RS19550	COG2188	Transcriptional regulator
PF977_RS19555	COG2723	6-phospho-beta-galactosidase activity
PF977_RS19560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_RS19565	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF977_RS19570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_RS19575	COG2814	Major facilitator Superfamily
PF977_RS19580	COG1388	LysM domain
PF977_RS19585	COG1078	dGTPase activity
PF977_RS19590	COG0454	-acetyltransferase
PF977_RS19600	COG5646	InterPro IPR014922
PF977_RS19605	COG1785	Belongs to the alkaline phosphatase family
PF977_RS19615	COG1819	glycosyl
PF977_RS19620	COG3858	chitin binding
PF977_RS19620	COG1388	LysM domain
PF977_RS19625	COG1802	Transcriptional regulator
PF977_RS19630	COG0730	response to heat
PF977_RS19635	COG2814	Major facilitator Superfamily
PF977_RS19640	COG1846	Transcriptional regulator
PF977_RS19645	COG0778	Nitroreductase
PF977_RS19650	COG2409	Drug exporters of the RND superfamily
PF977_RS19650	COG1033	growth of symbiont in host cell
PF977_RS19655	COG1846	Transcriptional regulator
PF977_RS19660	COG2318	DinB family
PF977_RS19665	COG1113	amino acid transport
PF977_RS19670	COG0488	(ABC) transporter
PF977_RS19675	COG0456	acetyltransferase
PF977_RS19685	COG1309	transcriptional regulator
PF977_RS19700	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_RS19705	COG2323	membrane
PF977_RS19710	COG2323	membrane
PF977_RS19730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS19735	COG2259	Doxx family
PF977_RS19740	COG0346	lactoylglutathione lyase activity
PF977_RS19745	COG0778	Nitroreductase
PF977_RS19750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_RS19755	COG0789	Transcriptional regulator
PF977_RS19755	COG4978	Transcriptional regulator
PF977_RS19760	COG1811	Na channel or pump
PF977_RS19765	COG0596	Alpha beta hydrolase
PF977_RS19770	COG2409	Drug exporters of the RND superfamily
PF977_RS19775	COG2197	response regulator
PF977_RS19780	COG4585	Histidine kinase
PF977_RS19795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF977_RS19800	COG0640	Transcriptional regulator
PF977_RS19805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF977_RS19810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS19815	COG0697	spore germination
PF977_RS19820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS19830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF977_RS19835	COG0640	Transcriptional regulator
PF977_RS19845	COG1309	transcriptional regulator
PF977_RS19850	COG2814	Major facilitator Superfamily
PF977_RS19855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_RS19860	COG1733	regulation of RNA biosynthetic process
PF977_RS19865	COG3545	Serine hydrolase
PF977_RS19870	COG2030	dehydratase
PF977_RS19875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS19880	COG0697	spore germination
PF977_RS19885	COG1309	transcriptional regulator
PF977_RS19890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS19900	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
PF977_RS19910	COG0477	Major facilitator Superfamily
PF977_RS19915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS19920	COG2207	Transcriptional regulator
PF977_RS19920	COG3708	Transcriptional regulator
PF977_RS19925	COG0697	spore germination
PF977_RS19930	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS19930	COG2207	Transcriptional regulator
PF977_RS19935	COG0697	spore germination
PF977_RS19940	COG0457	Tetratricopeptide repeat
PF977_RS19945	COG1329	Transcriptional regulator
PF977_RS19950	COG1278	Cold shock
PF977_RS19955	COG0693	protein deglycase activity
PF977_RS19980	COG1476	TRANSCRIPTIONal
PF977_RS20030	COG3091	SprT-like family
PF977_RS20040	COG2183	response to ionizing radiation
PF977_RS20045	COG2208	phosphoserine phosphatase activity
PF977_RS20050	COG1191	sigma factor activity
PF977_RS20055	COG2172	sigma factor antagonist activity
PF977_RS20060	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS20065	COG2208	phosphoserine phosphatase activity
PF977_RS20070	COG2172	sigma factor antagonist activity
PF977_RS20075	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS20080	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_RS20085	COG2337	Toxic component of a toxin-antitoxin (TA) module
PF977_RS20090	COG0864	Transcriptional regulator
PF977_RS20095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF977_RS20100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF977_RS20105	COG0736	holo-[acyl-carrier-protein] synthase activity
PF977_RS20110	COG0705	Rhomboid family
PF977_RS20115	COG3428	Bacterial PH domain
PF977_RS20120	COG3402	PFAM membrane-flanked domain
PF977_RS20125	COG0513	Belongs to the DEAD box helicase family
PF977_RS20130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF977_RS20135	COG1181	Belongs to the D-alanine--D-alanine ligase family
PF977_RS20140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_RS20145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_RS20160	COG1960	acyl-CoA dehydrogenase activity
PF977_RS20170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_RS20175	COG1131	(ABC) transporter
PF977_RS20180	COG0628	permease
PF977_RS20185	COG1301	dicarboxylic acid transport
PF977_RS20190	COG4565	transcriptional regulatory protein
PF977_RS20195	COG3290	protein histidine kinase activity
PF977_RS20200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PF977_RS20205	COG3546	catalase activity
PF977_RS20210	COG2329	Antibiotic biosynthesis monooxygenase
PF977_RS20215	COG0662	Cupin 2, conserved barrel domain protein
PF977_RS20220	COG3729	General stress protein
PF977_RS20225	COG2217	Heavy metal translocating P-type atpase
PF977_RS20230	COG4876	unkown
PF977_RS20235	COG2261	transglycosylase associated protein
PF977_RS20240	COG1914	H( )-stimulated, divalent metal cation uptake system
PF977_RS20255	COG0028	Belongs to the TPP enzyme family
PF977_RS20260	COG0494	nUDIX hydrolase
PF977_RS20265	COG0531	amino acid
PF977_RS20275	COG1215	transferase activity, transferring glycosyl groups
PF977_RS20285	COG3706	GGDEF domain
PF977_RS20290	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PF977_RS20295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF977_RS20295	COG0551	DNA topoisomerase type I activity
PF977_RS20300	COG1522	sequence-specific DNA binding
PF977_RS20305	COG2814	Major facilitator Superfamily
PF977_RS20315	COG3871	stress protein (general stress protein 26)
PF977_RS20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS20325	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS20330	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS20335	COG2226	methyltransferase
PF977_RS20340	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_RS20345	COG3711	transcriptional antiterminator
PF977_RS20350	COG4989	oxidoreductase activity
PF977_RS20355	COG0768	penicillin binding
PF977_RS20360	COG2329	Antibiotic biosynthesis monooxygenase
PF977_RS20370	COG2755	lipolytic protein G-D-S-L family
PF977_RS20375	COG1414	Transcriptional regulator
PF977_RS20380	COG1984	allophanate hydrolase subunit 2
PF977_RS20385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PF977_RS20390	COG4336	lyase activity
PF977_RS20395	COG1914	H( )-stimulated, divalent metal cation uptake system
PF977_RS20400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PF977_RS20405	COG0561	phosphatase activity
PF977_RS20415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF977_RS20420	COG0412	Dienelactone hydrolase
PF977_RS20425	COG0681	Belongs to the peptidase S26 family
PF977_RS20430	COG0473	3-isopropylmalate dehydrogenase activity
PF977_RS20435	COG0246	Mannitol dehydrogenase
PF977_RS20440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_RS20445	COG2213	PTS system mannitol-specific
PF977_RS20455	COG1349	DNA-binding transcription factor activity
PF977_RS20460	COG1276	copper resistance
PF977_RS20460	COG2372	response to copper ion
PF977_RS20465	COG4549	nuclear export factor GLE1
PF977_RS20470	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS20475	COG4975	Glucose uptake
PF977_RS20480	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS20485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF977_RS20490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS20495	COG0640	Transcriptional regulator
PF977_RS20500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF977_RS20505	COG0778	Nitroreductase
PF977_RS20510	COG1309	transcriptional regulator
PF977_RS20515	COG2814	Major facilitator Superfamily
PF977_RS20520	COG4607	ABC-type enterochelin transport system periplasmic component
PF977_RS20525	COG4604	ABC transporter, ATP-binding protein
PF977_RS20530	COG4605	iron ion homeostasis
PF977_RS20535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS20540	COG0527	aspartate kinase activity
PF977_RS20560	COG0457	Tetratricopeptide repeat
PF977_RS20565	COG3850	Histidine kinase
PF977_RS20565	COG5002	protein histidine kinase activity
PF977_RS20570	COG0745	RESPONSE REGULATOR receiver
PF977_RS20575	COG0577	efflux transmembrane transporter activity
PF977_RS20580	COG1136	(ABC) transporter
PF977_RS20585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF977_RS20595	COG0697	spore germination
PF977_RS20605	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_RS20610	COG3104	oligopeptide transport
PF977_RS20615	COG0596	Alpha beta hydrolase
PF977_RS20630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PF977_RS20635	COG0163	prenyltransferase activity
PF977_RS20640	COG0583	DNA-binding transcription factor activity
PF977_RS20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS20650	COG0765	amino acid transport
PF977_RS20655	COG1126	abc transporter atp-binding protein
PF977_RS20660	COG2364	Membrane
PF977_RS20670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_RS20675	COG0697	spore germination
PF977_RS20685	COG2814	Major facilitator Superfamily
PF977_RS20690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF977_RS20695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS20700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS20720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_RS20725	COG1733	regulation of RNA biosynthetic process
PF977_RS20730	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PF977_RS20735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF977_RS20740	COG3290	protein histidine kinase activity
PF977_RS20740	COG0840	transmembrane signaling receptor activity
PF977_RS20745	COG3209	COG3209 Rhs family protein
PF977_RS20755	COG2723	6-phospho-beta-galactosidase activity
PF977_RS20775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_RS20780	COG0765	amino acid transport
PF977_RS20785	COG0523	cobalamin synthesis protein
PF977_RS20795	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_RS20800	COG1469	GTP cyclohydrolase I activity
PF977_RS20805	COG2223	nitrite transmembrane transporter activity
PF977_RS20810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_RS20815	COG0243	molybdopterin cofactor binding
PF977_RS20820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_RS20825	COG2146	nitrite reductase [NAD(P)H] activity
PF977_RS20830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF977_RS20830	COG1587	Uroporphyrinogen-III synthase
PF977_RS20835	COG0492	ferredoxin-NADP+ reductase activity
PF977_RS20840	COG2267	carboxylic ester hydrolase activity
PF977_RS20845	COG0701	Predicted permease
PF977_RS20850	COG3689	TIGRFAM TIGR03943 family protein
PF977_RS20855	COG2508	Transcriptional regulator
PF977_RS20860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_RS20865	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS20870	COG0506	proline dehydrogenase activity
PF977_RS20875	COG3541	Predicted nucleotidyltransferase
PF977_RS20880	COG3458	cephalosporin-C deacetylase activity
PF977_RS20890	COG2226	methyltransferase
PF977_RS20895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PF977_RS20900	COG1660	Displays ATPase and GTPase activities
PF977_RS20905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF977_RS20910	COG3665	Urea carboxylase-associated protein
PF977_RS20915	COG1113	amino acid transport
PF977_RS20920	COG3403	YqcI/YcgG family
PF977_RS20925	COG1280	lysine exporter protein (LysE YggA)
PF977_RS20930	COG1846	Transcriptional regulator
PF977_RS20935	COG2814	Major facilitator Superfamily
PF977_RS20940	COG1620	l-lactate permease
PF977_RS20945	COG0039	L-malate dehydrogenase activity
PF977_RS20950	COG0366	Alpha amylase catalytic
PF977_RS20960	COG1288	antiporter activity
PF977_RS20965	COG1473	amidohydrolase
PF977_RS20970	COG2113	Glycine betaine
PF977_RS20975	COG4176	ABC-type proline glycine betaine transport system permease component
PF977_RS20980	COG4175	Glycine betaine
PF977_RS20980	COG0517	IMP dehydrogenase activity
PF977_RS20985	COG0640	Transcriptional regulator
PF977_RS20995	COG0477	Major facilitator Superfamily
PF977_RS21000	COG3853	Toxic anion resistance protein (TelA)
PF977_RS21010	COG0861	Integral membrane protein TerC family
PF977_RS21015	COG2310	stress, protein
PF977_RS21020	COG2310	stress, protein
PF977_RS21025	COG2310	stress, protein
PF977_RS21030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_RS21035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_RS21040	COG1121	(ABC) transporter
PF977_RS21045	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF977_RS21050	COG0366	Alpha amylase catalytic
PF977_RS21055	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_RS21060	COG0457	Tetratricopeptide repeat
PF977_RS21065	COG1876	peptidase activity
PF977_RS21070	COG1595	DNA-templated transcription, initiation
PF977_RS21075	COG1595	DNA-templated transcription, initiation
PF977_RS21090	COG0667	Aldo Keto reductase
PF977_RS21095	COG1668	transmembrane transport
PF977_RS21100	COG4555	ABC transporter
PF977_RS21105	COG3279	Response regulator of the LytR AlgR family
PF977_RS21110	COG3290	protein histidine kinase activity
PF977_RS21115	COG3012	SEC-C Motif Domain Protein
PF977_RS21115	COG1405	negative regulation of cell septum assembly
PF977_RS21120	COG1714	RDD family
PF977_RS21125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PF977_RS21130	COG0252	asparaginase activity
PF977_RS21135	COG1309	transcriptional regulator
PF977_RS21140	COG0477	Major facilitator Superfamily
PF977_RS21150	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PF977_RS21155	COG0805	protein transport
PF977_RS21160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_RS21165	COG3540	Alkaline phosphatase
PF977_RS21175	COG2304	oxidoreductase activity
PF977_RS21180	COG3773	Cell wall hydrolase
PF977_RS21200	COG1131	(ABC) transporter
PF977_RS21205	COG2205	protein histidine kinase activity
PF977_RS21210	COG0745	RESPONSE REGULATOR receiver
PF977_RS21215	COG0697	spore germination
PF977_RS21225	COG3173	Aminoglycoside phosphotransferase
PF977_RS21230	COG2721	sulfolactate sulfo-lyase activity
PF977_RS21235	COG2186	Transcriptional regulator
PF977_RS21240	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_RS21245	COG2271	Major facilitator Superfamily
PF977_RS21250	COG1012	belongs to the aldehyde dehydrogenase family
PF977_RS21255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF977_RS21260	COG0784	Response regulator, receiver
PF977_RS21265	COG4191	Histidine kinase
PF977_RS21270	COG2066	Belongs to the glutaminase family
PF977_RS21275	COG1115	amino acid carrier protein
PF977_RS21280	COG2040	homocysteine
PF977_RS21285	COG0833	amino acid
PF977_RS21290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_RS21300	COG2188	Transcriptional regulator
PF977_RS21305	COG0363	glucosamine-6-phosphate deaminase activity
PF977_RS21310	COG1263	PTS System
PF977_RS21310	COG2190	(PTS) system
PF977_RS21310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS21315	COG1301	dicarboxylic acid transport
PF977_RS21320	COG1054	Belongs to the UPF0176 family
PF977_RS21325	COG2312	Erythromycin esterase
PF977_RS21335	COG0688	phosphatidylethanolamine metabolic process
PF977_RS21340	COG0586	Pfam SNARE associated Golgi protein
PF977_RS21345	COG1183	phosphatidylcholine synthase activity
PF977_RS21350	COG0596	Alpha beta hydrolase
PF977_RS21360	COG3591	Belongs to the peptidase S1B family
PF977_RS21365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF977_RS21370	COG1917	Cupin 2, conserved barrel domain protein
PF977_RS21370	COG2207	Transcriptional regulator
PF977_RS21375	COG0697	spore germination
PF977_RS21380	COG2271	Major facilitator Superfamily
PF977_RS21385	COG1846	Transcriptional regulator
PF977_RS21385	COG0456	acetyltransferase
PF977_RS21395	COG2271	Major facilitator Superfamily
PF977_RS21400	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_RS21410	COG0531	amino acid
PF977_RS21420	COG2124	cytochrome p450
PF977_RS21425	COG2602	Beta-lactamase
PF977_RS21440	COG1113	amino acid transport
PF977_RS21455	COG0515	serine threonine protein kinase
PF977_RS21465	COG0642	Histidine kinase
PF977_RS21470	COG0745	RESPONSE REGULATOR receiver
PF977_RS21475	COG0596	Alpha beta hydrolase
PF977_RS21480	COG1132	(ABC) transporter
PF977_RS21500	COG1404	Belongs to the peptidase S8 family
PF977_RS21515	COG2814	Major facilitator Superfamily
PF977_RS21520	COG0640	Transcriptional regulator
PF977_RS21525	COG5609	conserved protein (DUF2294)
PF977_RS21535	COG0288	reversible hydration of carbon dioxide
PF977_RS21540	COG3002	Belongs to the UPF0753 family
PF977_RS21545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF977_RS21550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF977_RS21555	COG2169	Transcriptional regulator
PF977_RS21560	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF977_RS21570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF977_RS21575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF977_RS21580	COG4856	YbbR-like protein
PF977_RS21585	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF977_RS21590	COG5662	AntiSigma factor
PF977_RS21595	COG1595	DNA-templated transcription, initiation
PF977_RS21630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_RS21635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PF977_RS21640	COG1737	Transcriptional regulator
PF977_RS21645	COG1263	PTS System
PF977_RS21645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_RS21650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_RS21655	COG1472	Belongs to the glycosyl hydrolase 3 family
PF977_RS21660	COG3876	Protein conserved in bacteria
PF977_RS21665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS21665	COG2207	Transcriptional regulator
PF977_RS21670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_RS21675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS21680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_RS21685	COG2819	hydrolase of the alpha beta superfamily
PF977_RS21690	COG0385	Bile acid
PF977_RS21695	COG0659	secondary active sulfate transmembrane transporter activity
PF977_RS21780	COG0726	polysaccharide deacetylase
PF977_RS21785	COG2194	sulfuric ester hydrolase activity
PF977_RS21795	COG0489	protein tyrosine kinase activity
PF977_RS21800	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_RS21810	COG2226	methyltransferase
PF977_RS21815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF977_RS21820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PF977_RS21825	COG0101	tRNA pseudouridine synthase activity
PF977_RS21830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF977_RS21835	COG1122	ATPase activity
PF977_RS21840	COG1122	ATPase activity
PF977_RS21845	COG0203	ribosomal protein L17
PF977_RS21850	COG0202	RNA polymerase activity
PF977_RS21855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PF977_RS21860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PF977_RS21865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF977_RS21875	COG2163	COG2163 Ribosomal protein L14E L6E L27E
PF977_RS21880	COG0024	Methionine aminopeptidase
PF977_RS21885	COG0563	adenylate kinase activity
PF977_RS21890	COG0201	protein transport
PF977_RS21895	COG0200	Binds to the 23S rRNA
PF977_RS21905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PF977_RS21910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PF977_RS21915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PF977_RS21920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PF977_RS21930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PF977_RS21940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PF977_RS21945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PF977_RS21955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PF977_RS21960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PF977_RS21975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PF977_RS21985	COG0088	Forms part of the polypeptide exit tunnel
PF977_RS21990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PF977_RS22000	COG0596	Alpha beta hydrolase
PF977_RS22005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PF977_RS22010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PF977_RS22015	COG0049	tRNA binding
PF977_RS22020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PF977_RS22025	COG1358	cellular component organization or biogenesis
PF977_RS22030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PF977_RS22035	COG0085	RNA polymerase activity
PF977_RS22040	COG2813	Specifically methylates the guanine in position
PF977_RS22050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PF977_RS22055	COG0081	regulation of translation
PF977_RS22065	COG0250	Participates in transcription elongation, termination and antitermination
PF977_RS22070	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF977_RS22080	COG1595	DNA-templated transcription, initiation
PF977_RS22085	COG3688	RNA-binding protein containing a PIN domain
PF977_RS22090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF977_RS22095	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PF977_RS22100	COG0215	cysteine-tRNA ligase activity
PF977_RS22105	COG1045	serine acetyltransferase
PF977_RS22110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF977_RS22115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PF977_RS22120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PF977_RS22125	COG4956	integral membrane protein (PIN domain superfamily)
PF977_RS22130	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PF977_RS22135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PF977_RS22140	COG0542	response to heat
PF977_RS22145	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PF977_RS22150	COG3880	PFAM UvrB UvrC protein
PF977_RS22155	COG4463	regulation of RNA biosynthetic process
PF977_RS22235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PF977_RS22240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF977_RS22245	COG1396	sequence-specific DNA binding
PF977_RS22250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF977_RS22255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF977_RS22260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF977_RS22265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_RS22270	COG0512	Glutamine amidotransferase of anthranilate synthase
PF977_RS22275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF977_RS22280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_RS22285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF977_RS22290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PF977_RS22295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PF977_RS22300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF977_RS22305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PF977_RS22310	COG0037	tRNA processing
PF977_RS22315	COG0515	serine threonine protein kinase
PF977_RS22320	COG2304	oxidoreductase activity
PF977_RS22325	COG2208	phosphoserine phosphatase activity
PF977_RS22340	COG1098	S1 RNA binding domain
PF977_RS22345	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF977_RS22360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF977_RS22365	COG3956	TIGRFAM MazG family protein
PF977_RS22370	COG2244	polysaccharide biosynthetic process
PF977_RS22375	COG2002	toxin-antitoxin pair type II binding
PF977_RS22380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF977_RS22390	COG0193	aminoacyl-tRNA hydrolase activity
PF977_RS22395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PF977_RS22400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF977_RS22405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PF977_RS22410	COG2088	sporulation resulting in formation of a cellular spore
PF977_RS22415	COG0251	oxidation-reduction process
PF977_RS22420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_RS22425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PF977_RS22435	COG4466	Protein conserved in bacteria
PF977_RS22445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF977_RS22450	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF977_RS22455	COG3583	domain protein
PF977_RS22455	COG3584	3D domain protein
PF977_RS22460	COG0084	hydrolase, TatD family'
PF977_RS22465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_RS22465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_RS22470	COG2002	toxin-antitoxin pair type II binding
PF977_RS22475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PF977_RS22480	COG2827	Endonuclease containing a URI domain
PF977_RS22485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PF977_RS22490	COG4467	Involved in initiation control of chromosome replication
PF977_RS22495	COG1774	PSP1 C-terminal conserved region
PF977_RS22500	COG0470	DNA polymerase III
PF977_RS22505	COG1728	Protein conserved in bacteria
PF977_RS22510	COG3870	Protein conserved in bacteria
PF977_RS22515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF977_RS22520	COG1982	Orn Lys Arg decarboxylase major
PF977_RS22525	COG3853	Toxic anion resistance protein (TelA)
PF977_RS22530	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
PF977_RS22575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF977_RS22580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PF977_RS22585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF977_RS22595	COG0590	tRNA wobble adenosine to inosine editing
PF977_RS22600	COG1335	isochorismatase
PF977_RS22605	COG1388	LysM domain
PF977_RS22605	COG3858	chitin binding
PF977_RS22610	COG1428	Deoxynucleoside kinase
PF977_RS22615	COG1428	Deoxynucleoside kinase
PF977_RS22625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PF977_RS22630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PF977_RS22635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PF977_RS22640	COG1686	Belongs to the peptidase S11 family
PF977_RS22645	COG0516	GMP reductase activity
PF977_RS22645	COG0517	IMP dehydrogenase activity
PF977_RS22680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF977_RS22685	COG0187	DNA topoisomerase II activity
PF977_RS22695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PF977_RS22700	COG2501	S4 domain
PF977_RS22705	COG0592	DNA-directed DNA polymerase activity