locus-tag	class	description
MID01_RS00010	COG0592	DNA-directed DNA polymerase activity
MID01_RS00015	COG2501	S4 domain
MID01_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MID01_RS00030	COG0187	DNA topoisomerase II activity
MID01_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MID01_RS00070	COG0516	GMP reductase activity
MID01_RS00070	COG0517	IMP dehydrogenase activity
MID01_RS00075	COG1686	Belongs to the peptidase S11 family
MID01_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MID01_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MID01_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MID01_RS00100	COG1428	Deoxynucleoside kinase
MID01_RS00105	COG1428	Deoxynucleoside kinase
MID01_RS00110	COG1388	LysM domain
MID01_RS00110	COG3858	chitin binding
MID01_RS00115	COG1335	isochorismatase
MID01_RS00120	COG0590	tRNA wobble adenosine to inosine editing
MID01_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MID01_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MID01_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MID01_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MID01_RS00190	COG3853	Toxic anion resistance protein (TelA)
MID01_RS00195	COG1982	Orn Lys Arg decarboxylase major
MID01_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MID01_RS00205	COG3870	Protein conserved in bacteria
MID01_RS00210	COG1728	Protein conserved in bacteria
MID01_RS00215	COG0470	DNA polymerase III
MID01_RS00220	COG1774	PSP1 C-terminal conserved region
MID01_RS00225	COG4467	Involved in initiation control of chromosome replication
MID01_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MID01_RS00235	COG2827	Endonuclease containing a URI domain
MID01_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MID01_RS00245	COG2002	toxin-antitoxin pair type II binding
MID01_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID01_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID01_RS00255	COG0084	hydrolase, TatD family'
MID01_RS00260	COG3584	3D domain protein
MID01_RS00260	COG3583	domain protein
MID01_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MID01_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MID01_RS00280	COG4466	Protein conserved in bacteria
MID01_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MID01_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MID01_RS00300	COG0251	oxidation-reduction process
MID01_RS00305	COG2088	sporulation resulting in formation of a cellular spore
MID01_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MID01_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MID01_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MID01_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
MID01_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MID01_RS00340	COG2002	toxin-antitoxin pair type II binding
MID01_RS00345	COG2244	polysaccharide biosynthetic process
MID01_RS00350	COG3956	TIGRFAM MazG family protein
MID01_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MID01_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MID01_RS00375	COG1098	S1 RNA binding domain
MID01_RS00390	COG2208	phosphoserine phosphatase activity
MID01_RS00395	COG2304	oxidoreductase activity
MID01_RS00400	COG0515	serine threonine protein kinase
MID01_RS00405	COG0037	tRNA processing
MID01_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MID01_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MID01_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MID01_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MID01_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID01_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MID01_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MID01_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
MID01_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MID01_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MID01_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MID01_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MID01_RS00470	COG1396	sequence-specific DNA binding
MID01_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MID01_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MID01_RS00560	COG4463	regulation of RNA biosynthetic process
MID01_RS00565	COG3880	PFAM UvrB UvrC protein
MID01_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MID01_RS00575	COG0542	response to heat
MID01_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MID01_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MID01_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
MID01_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MID01_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MID01_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MID01_RS00610	COG1045	serine acetyltransferase
MID01_RS00615	COG0215	cysteine-tRNA ligase activity
MID01_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MID01_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MID01_RS00630	COG3688	RNA-binding protein containing a PIN domain
MID01_RS00635	COG1595	DNA-templated transcription, initiation
MID01_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MID01_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
MID01_RS00660	COG0081	regulation of translation
MID01_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MID01_RS00675	COG2813	Specifically methylates the guanine in position
MID01_RS00680	COG0085	RNA polymerase activity
MID01_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MID01_RS00690	COG1358	cellular component organization or biogenesis
MID01_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MID01_RS00700	COG0049	tRNA binding
MID01_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MID01_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MID01_RS00715	COG0596	Alpha beta hydrolase
MID01_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MID01_RS00730	COG0088	Forms part of the polypeptide exit tunnel
MID01_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MID01_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MID01_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MID01_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MID01_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MID01_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MID01_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MID01_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MID01_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MID01_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MID01_RS00820	COG0200	Binds to the 23S rRNA
MID01_RS00825	COG0201	protein transport
MID01_RS00830	COG0563	adenylate kinase activity
MID01_RS00835	COG0024	Methionine aminopeptidase
MID01_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
MID01_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MID01_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MID01_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MID01_RS00865	COG0202	RNA polymerase activity
MID01_RS00870	COG0203	ribosomal protein L17
MID01_RS00875	COG1122	ATPase activity
MID01_RS00880	COG1122	ATPase activity
MID01_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MID01_RS00890	COG0101	tRNA pseudouridine synthase activity
MID01_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MID01_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MID01_RS00905	COG2226	methyltransferase
MID01_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS00920	COG0489	protein tyrosine kinase activity
MID01_RS00930	COG2194	sulfuric ester hydrolase activity
MID01_RS00935	COG0726	polysaccharide deacetylase
MID01_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
MID01_RS01025	COG0385	Bile acid
MID01_RS01030	COG2819	hydrolase of the alpha beta superfamily
MID01_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS01050	COG2207	Transcriptional regulator
MID01_RS01055	COG3876	Protein conserved in bacteria
MID01_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
MID01_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MID01_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS01070	COG1263	PTS System
MID01_RS01075	COG1737	Transcriptional regulator
MID01_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MID01_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS01090	COG1683	Conserved Protein
MID01_RS01120	COG1595	DNA-templated transcription, initiation
MID01_RS01125	COG5662	AntiSigma factor
MID01_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MID01_RS01135	COG4856	YbbR-like protein
MID01_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MID01_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MID01_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MID01_RS01160	COG2169	Transcriptional regulator
MID01_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MID01_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MID01_RS01175	COG3002	Belongs to the UPF0753 family
MID01_RS01180	COG0288	reversible hydration of carbon dioxide
MID01_RS01190	COG5609	conserved protein (DUF2294)
MID01_RS01195	COG0640	Transcriptional regulator
MID01_RS01200	COG2814	Major facilitator Superfamily
MID01_RS01215	COG0515	serine threonine protein kinase
MID01_RS01230	COG1113	amino acid transport
MID01_RS01245	COG2602	Beta-lactamase
MID01_RS01250	COG2124	cytochrome p450
MID01_RS01260	COG0531	amino acid
MID01_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
MID01_RS01270	COG2271	Major facilitator Superfamily
MID01_RS01280	COG0456	acetyltransferase
MID01_RS01280	COG1846	Transcriptional regulator
MID01_RS01285	COG2271	Major facilitator Superfamily
MID01_RS01295	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS01300	COG0697	spore germination
MID01_RS01305	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS01305	COG2207	Transcriptional regulator
MID01_RS01310	COG1397	ADP-ribosylglycohydrolase
MID01_RS01315	COG5444	nuclease activity
MID01_RS01320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MID01_RS01325	COG3591	Belongs to the peptidase S1B family
MID01_RS01335	COG0596	Alpha beta hydrolase
MID01_RS01340	COG1183	phosphatidylcholine synthase activity
MID01_RS01345	COG0586	Pfam SNARE associated Golgi protein
MID01_RS01350	COG0688	phosphatidylethanolamine metabolic process
MID01_RS01360	COG2312	Erythromycin esterase
MID01_RS01365	COG1054	Belongs to the UPF0176 family
MID01_RS01370	COG1301	dicarboxylic acid transport
MID01_RS01375	COG1263	PTS System
MID01_RS01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS01375	COG2190	(PTS) system
MID01_RS01380	COG0363	glucosamine-6-phosphate deaminase activity
MID01_RS01385	COG2188	Transcriptional regulator
MID01_RS01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MID01_RS01400	COG0833	amino acid
MID01_RS01405	COG2040	homocysteine
MID01_RS01410	COG1115	amino acid carrier protein
MID01_RS01415	COG2066	Belongs to the glutaminase family
MID01_RS01420	COG4191	Histidine kinase
MID01_RS01425	COG0784	Response regulator, receiver
MID01_RS01430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MID01_RS01435	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS01440	COG2271	Major facilitator Superfamily
MID01_RS01445	COG4948	Mandelate Racemase Muconate Lactonizing
MID01_RS01450	COG2186	Transcriptional regulator
MID01_RS01455	COG2721	sulfolactate sulfo-lyase activity
MID01_RS01460	COG3173	Aminoglycoside phosphotransferase
MID01_RS01470	COG0697	spore germination
MID01_RS01475	COG0745	RESPONSE REGULATOR receiver
MID01_RS01480	COG2205	protein histidine kinase activity
MID01_RS01485	COG1131	(ABC) transporter
MID01_RS01505	COG3773	Cell wall hydrolase
MID01_RS01510	COG2304	oxidoreductase activity
MID01_RS01520	COG3540	Alkaline phosphatase
MID01_RS01525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MID01_RS01530	COG0805	protein transport
MID01_RS01535	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MID01_RS01540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MID01_RS01545	COG0477	Major facilitator Superfamily
MID01_RS01550	COG1309	transcriptional regulator
MID01_RS01555	COG0252	asparaginase activity
MID01_RS01560	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MID01_RS01565	COG1714	RDD family
MID01_RS01570	COG1405	negative regulation of cell septum assembly
MID01_RS01570	COG3012	SEC-C Motif Domain Protein
MID01_RS01575	COG3290	protein histidine kinase activity
MID01_RS01580	COG3279	Response regulator of the LytR AlgR family
MID01_RS01585	COG4555	ABC transporter
MID01_RS01590	COG1668	transmembrane transport
MID01_RS01595	COG0667	Aldo Keto reductase
MID01_RS01610	COG1595	DNA-templated transcription, initiation
MID01_RS01615	COG1595	DNA-templated transcription, initiation
MID01_RS01620	COG1876	peptidase activity
MID01_RS01625	COG0457	Tetratricopeptide repeat
MID01_RS01630	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS01635	COG0366	Alpha amylase catalytic
MID01_RS01640	COG0803	Belongs to the bacterial solute-binding protein 9 family
MID01_RS01645	COG1121	(ABC) transporter
MID01_RS01650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MID01_RS01655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS01660	COG2310	stress, protein
MID01_RS01665	COG2310	stress, protein
MID01_RS01670	COG2310	stress, protein
MID01_RS01675	COG0861	Integral membrane protein TerC family
MID01_RS01685	COG3853	Toxic anion resistance protein (TelA)
MID01_RS01690	COG0477	Major facilitator Superfamily
MID01_RS01695	COG2814	Major facilitator Superfamily
MID01_RS01700	COG0640	Transcriptional regulator
MID01_RS01705	COG0517	IMP dehydrogenase activity
MID01_RS01705	COG4175	Glycine betaine
MID01_RS01710	COG4176	ABC-type proline glycine betaine transport system permease component
MID01_RS01715	COG2113	Glycine betaine
MID01_RS01720	COG1473	amidohydrolase
MID01_RS01725	COG1288	antiporter activity
MID01_RS01735	COG0366	Alpha amylase catalytic
MID01_RS01740	COG0039	L-malate dehydrogenase activity
MID01_RS01745	COG1620	l-lactate permease
MID01_RS01750	COG2814	Major facilitator Superfamily
MID01_RS01755	COG1846	Transcriptional regulator
MID01_RS01760	COG1280	lysine exporter protein (LysE YggA)
MID01_RS01765	COG3403	YqcI/YcgG family
MID01_RS01770	COG1113	amino acid transport
MID01_RS01775	COG3665	Urea carboxylase-associated protein
MID01_RS01780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MID01_RS01785	COG1660	Displays ATPase and GTPase activities
MID01_RS01790	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MID01_RS01795	COG2226	methyltransferase
MID01_RS01800	COG0583	DNA-binding transcription factor activity
MID01_RS01805	COG3458	cephalosporin-C deacetylase activity
MID01_RS01810	COG3541	Predicted nucleotidyltransferase
MID01_RS01815	COG0506	proline dehydrogenase activity
MID01_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS01825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID01_RS01830	COG2508	Transcriptional regulator
MID01_RS01835	COG3689	TIGRFAM TIGR03943 family protein
MID01_RS01840	COG0701	Predicted permease
MID01_RS01845	COG2267	carboxylic ester hydrolase activity
MID01_RS01850	COG0492	ferredoxin-NADP+ reductase activity
MID01_RS01855	COG1587	Uroporphyrinogen-III synthase
MID01_RS01855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MID01_RS01860	COG2146	nitrite reductase [NAD(P)H] activity
MID01_RS01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MID01_RS01870	COG0243	molybdopterin cofactor binding
MID01_RS01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MID01_RS01880	COG2223	nitrite transmembrane transporter activity
MID01_RS01885	COG1469	GTP cyclohydrolase I activity
MID01_RS01890	COG1376	ErfK ybiS ycfS ynhG family protein
MID01_RS01900	COG0523	cobalamin synthesis protein
MID01_RS01905	COG0765	amino acid transport
MID01_RS01910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS01920	COG1714	RDD family
MID01_RS01930	COG2723	6-phospho-beta-galactosidase activity
MID01_RS01940	COG3209	COG3209 Rhs family protein
MID01_RS01945	COG0840	transmembrane signaling receptor activity
MID01_RS01945	COG3290	protein histidine kinase activity
MID01_RS01950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MID01_RS01955	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MID01_RS01960	COG1733	regulation of RNA biosynthetic process
MID01_RS01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS01995	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
MID01_RS02000	COG2814	Major facilitator Superfamily
MID01_RS02010	COG0697	spore germination
MID01_RS02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS02025	COG2364	Membrane
MID01_RS02030	COG1126	abc transporter atp-binding protein
MID01_RS02035	COG0765	amino acid transport
MID01_RS02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS02045	COG0583	DNA-binding transcription factor activity
MID01_RS02050	COG0163	prenyltransferase activity
MID01_RS02055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MID01_RS02070	COG0596	Alpha beta hydrolase
MID01_RS02075	COG3104	oligopeptide transport
MID01_RS02080	COG5434	Belongs to the glycosyl hydrolase 28 family
MID01_RS02090	COG0697	spore germination
MID01_RS02100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MID01_RS02105	COG1136	(ABC) transporter
MID01_RS02110	COG0577	efflux transmembrane transporter activity
MID01_RS02115	COG0745	RESPONSE REGULATOR receiver
MID01_RS02120	COG5002	protein histidine kinase activity
MID01_RS02120	COG3850	Histidine kinase
MID01_RS02125	COG0457	Tetratricopeptide repeat
MID01_RS02145	COG0527	aspartate kinase activity
MID01_RS02150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS02155	COG4605	iron ion homeostasis
MID01_RS02160	COG4604	ABC transporter, ATP-binding protein
MID01_RS02165	COG4607	ABC-type enterochelin transport system periplasmic component
MID01_RS02170	COG2814	Major facilitator Superfamily
MID01_RS02175	COG1309	transcriptional regulator
MID01_RS02180	COG0778	Nitroreductase
MID01_RS02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MID01_RS02190	COG0640	Transcriptional regulator
MID01_RS02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MID01_RS02205	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS02210	COG4975	Glucose uptake
MID01_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS02220	COG4549	nuclear export factor GLE1
MID01_RS02225	COG1276	copper resistance
MID01_RS02225	COG2372	response to copper ion
MID01_RS02230	COG1349	DNA-binding transcription factor activity
MID01_RS02240	COG2213	PTS system mannitol-specific
MID01_RS02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS02250	COG0246	Mannitol dehydrogenase
MID01_RS02255	COG0473	3-isopropylmalate dehydrogenase activity
MID01_RS02260	COG0681	Belongs to the peptidase S26 family
MID01_RS02265	COG0412	Dienelactone hydrolase
MID01_RS02270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MID01_RS02280	COG0561	phosphatase activity
MID01_RS02285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MID01_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
MID01_RS02295	COG4336	lyase activity
MID01_RS02300	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MID01_RS02305	COG1984	allophanate hydrolase subunit 2
MID01_RS02310	COG1414	Transcriptional regulator
MID01_RS02315	COG2755	lipolytic protein G-D-S-L family
MID01_RS02325	COG2329	Antibiotic biosynthesis monooxygenase
MID01_RS02330	COG0768	penicillin binding
MID01_RS02335	COG4989	oxidoreductase activity
MID01_RS02340	COG3711	transcriptional antiterminator
MID01_RS02345	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS02350	COG2226	methyltransferase
MID01_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS02360	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS02365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS02370	COG3871	stress protein (general stress protein 26)
MID01_RS02380	COG2814	Major facilitator Superfamily
MID01_RS02385	COG1522	sequence-specific DNA binding
MID01_RS02390	COG0551	DNA topoisomerase type I activity
MID01_RS02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MID01_RS02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MID01_RS02400	COG3706	GGDEF domain
MID01_RS02405	COG5298	Protein conserved in bacteria
MID01_RS02410	COG1215	transferase activity, transferring glycosyl groups
MID01_RS02420	COG0531	amino acid
MID01_RS02425	COG0494	nUDIX hydrolase
MID01_RS02430	COG0028	Belongs to the TPP enzyme family
MID01_RS02445	COG1914	H( )-stimulated, divalent metal cation uptake system
MID01_RS02450	COG2261	transglycosylase associated protein
MID01_RS02455	COG4876	unkown
MID01_RS02460	COG2217	Heavy metal translocating P-type atpase
MID01_RS02465	COG3729	General stress protein
MID01_RS02470	COG0662	Cupin 2, conserved barrel domain protein
MID01_RS02475	COG2329	Antibiotic biosynthesis monooxygenase
MID01_RS02480	COG3546	catalase activity
MID01_RS02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MID01_RS02490	COG3290	protein histidine kinase activity
MID01_RS02495	COG4565	transcriptional regulatory protein
MID01_RS02500	COG1301	dicarboxylic acid transport
MID01_RS02505	COG0628	permease
MID01_RS02510	COG1131	(ABC) transporter
MID01_RS02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MID01_RS02525	COG1960	acyl-CoA dehydrogenase activity
MID01_RS02540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MID01_RS02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS02550	COG1181	Belongs to the D-alanine--D-alanine ligase family
MID01_RS02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MID01_RS02560	COG0513	Belongs to the DEAD box helicase family
MID01_RS02565	COG3402	PFAM membrane-flanked domain
MID01_RS02570	COG3428	Bacterial PH domain
MID01_RS02575	COG0705	Rhomboid family
MID01_RS02580	COG0736	holo-[acyl-carrier-protein] synthase activity
MID01_RS02585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MID01_RS02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MID01_RS02595	COG0864	Transcriptional regulator
MID01_RS02600	COG2337	Toxic component of a toxin-antitoxin (TA) module
MID01_RS02605	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS02610	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS02615	COG2172	sigma factor antagonist activity
MID01_RS02620	COG2208	phosphoserine phosphatase activity
MID01_RS02625	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS02630	COG2172	sigma factor antagonist activity
MID01_RS02635	COG1191	sigma factor activity
MID01_RS02640	COG2208	phosphoserine phosphatase activity
MID01_RS02645	COG2183	response to ionizing radiation
MID01_RS02655	COG3091	SprT-like family
MID01_RS02695	COG0582	viral genome integration into host DNA
MID01_RS02710	COG0457	Tetratricopeptide repeat
MID01_RS02735	COG5444	nuclease activity
MID01_RS02745	COG1476	TRANSCRIPTIONal
MID01_RS02755	COG3239	Fatty acid desaturase
MID01_RS02760	COG1278	Cold shock
MID01_RS02765	COG1329	Transcriptional regulator
MID01_RS02770	COG0697	spore germination
MID01_RS02775	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS02775	COG2207	Transcriptional regulator
MID01_RS02780	COG0697	spore germination
MID01_RS02785	COG3708	Transcriptional regulator
MID01_RS02785	COG2207	Transcriptional regulator
MID01_RS02790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS02795	COG0477	Major facilitator Superfamily
MID01_RS02805	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MID01_RS02820	COG1309	transcriptional regulator
MID01_RS02825	COG0697	spore germination
MID01_RS02830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS02835	COG2030	dehydratase
MID01_RS02840	COG3545	Serine hydrolase
MID01_RS02845	COG1733	regulation of RNA biosynthetic process
MID01_RS02850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS02855	COG1733	regulation of RNA biosynthetic process
MID01_RS02860	COG2249	NAD(P)H dehydrogenase (quinone) activity
MID01_RS02865	COG2814	Major facilitator Superfamily
MID01_RS02870	COG1309	transcriptional regulator
MID01_RS02875	COG0640	Transcriptional regulator
MID01_RS02880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MID01_RS02890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS02895	COG0697	spore germination
MID01_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS02905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MID01_RS02910	COG0640	Transcriptional regulator
MID01_RS02915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MID01_RS02930	COG4585	Histidine kinase
MID01_RS02935	COG2197	response regulator
MID01_RS02940	COG2409	Drug exporters of the RND superfamily
MID01_RS02945	COG0596	Alpha beta hydrolase
MID01_RS02950	COG1811	Na channel or pump
MID01_RS02955	COG4978	Transcriptional regulator
MID01_RS02955	COG0789	Transcriptional regulator
MID01_RS02960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MID01_RS02965	COG0778	Nitroreductase
MID01_RS02970	COG0346	lactoylglutathione lyase activity
MID01_RS02975	COG2259	Doxx family
MID01_RS02980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS03000	COG2323	membrane
MID01_RS03005	COG2323	membrane
MID01_RS03010	COG0071	Belongs to the small heat shock protein (HSP20) family
MID01_RS03025	COG1309	transcriptional regulator
MID01_RS03035	COG0456	acetyltransferase
MID01_RS03040	COG0488	(ABC) transporter
MID01_RS03045	COG1113	amino acid transport
MID01_RS03050	COG2318	DinB family
MID01_RS03055	COG1846	Transcriptional regulator
MID01_RS03060	COG2409	Drug exporters of the RND superfamily
MID01_RS03060	COG1033	growth of symbiont in host cell
MID01_RS03065	COG0778	Nitroreductase
MID01_RS03070	COG1846	Transcriptional regulator
MID01_RS03075	COG2814	Major facilitator Superfamily
MID01_RS03080	COG0730	response to heat
MID01_RS03085	COG1802	Transcriptional regulator
MID01_RS03090	COG1388	LysM domain
MID01_RS03090	COG3858	chitin binding
MID01_RS03095	COG1819	glycosyl
MID01_RS03105	COG1785	Belongs to the alkaline phosphatase family
MID01_RS03110	COG5646	InterPro IPR014922
MID01_RS03120	COG0454	-acetyltransferase
MID01_RS03125	COG1078	dGTPase activity
MID01_RS03130	COG1388	LysM domain
MID01_RS03135	COG2814	Major facilitator Superfamily
MID01_RS03140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MID01_RS03145	COG1447	Phosphotransferase system cellobiose-specific component IIA
MID01_RS03150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MID01_RS03155	COG2723	6-phospho-beta-galactosidase activity
MID01_RS03160	COG2188	Transcriptional regulator
MID01_RS03165	COG1940	carbohydrate kinase activity
MID01_RS03170	COG1482	cell wall glycoprotein biosynthetic process
MID01_RS03175	COG4124	Belongs to the glycosyl hydrolase 26 family
MID01_RS03220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MID01_RS03225	COG0802	atpase or kinase
MID01_RS03230	COG1214	PFAM Peptidase M22, glycoprotease
MID01_RS03235	COG0456	acetyltransferase
MID01_RS03240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MID01_RS03245	COG0488	(ABC) transporter
MID01_RS03250	COG0315	cyclic pyranopterin monophosphate synthase activity
MID01_RS03255	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MID01_RS03260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MID01_RS03265	COG0805	protein transport
MID01_RS03275	COG1266	CAAX protease self-immunity
MID01_RS03285	COG0459	protein refolding
MID01_RS03290	COG1073	alpha beta
MID01_RS03295	COG0457	Tetratricopeptide repeat
MID01_RS03300	COG1063	alcohol dehydrogenase
MID01_RS03305	COG2211	Major facilitator Superfamily
MID01_RS03310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID01_RS03315	COG1842	Phage shock protein A
MID01_RS03320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MID01_RS03325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MID01_RS03330	COG4260	virion core protein, lumpy skin disease virus
MID01_RS03340	COG2814	Major facilitator Superfamily
MID01_RS03345	COG1063	alcohol dehydrogenase
MID01_RS03350	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MID01_RS03355	COG0823	Involved in the tonB-independent uptake of proteins
MID01_RS03370	COG2267	carboxylic ester hydrolase activity
MID01_RS03380	COG2132	Multicopper oxidase
MID01_RS03385	COG1113	amino acid transport
MID01_RS03395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MID01_RS03400	COG0714	Associated with various cellular activities
MID01_RS03405	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MID01_RS03410	COG1305	Transglutaminase-like
MID01_RS03415	COG0519	Catalyzes the synthesis of GMP from XMP
MID01_RS03415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MID01_RS03430	COG2252	PERMEase
MID01_RS03435	COG3064	Membrane
MID01_RS03445	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MID01_RS03455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MID01_RS03460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MID01_RS03465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MID01_RS03470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MID01_RS03475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MID01_RS03480	COG0047	phosphoribosylformylglycinamidine synthase activity
MID01_RS03485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MID01_RS03490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MID01_RS03495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MID01_RS03500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MID01_RS03505	COG0138	bifunctional purine biosynthesis protein purh
MID01_RS03510	COG0151	Belongs to the GarS family
MID01_RS03515	COG1522	sequence-specific DNA binding
MID01_RS03520	COG0531	amino acid
MID01_RS03530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MID01_RS03535	COG1470	cell adhesion involved in biofilm formation
MID01_RS03540	COG4496	protein, YerC YecD
MID01_RS03545	COG0069	glutamate synthase activity
MID01_RS03550	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MID01_RS03555	COG0210	DNA helicase
MID01_RS03560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MID01_RS03565	COG4851	CamS sex pheromone cAM373 precursor
MID01_RS03570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID01_RS03575	COG1285	pathogenesis
MID01_RS03580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID01_RS03585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MID01_RS03590	COG0154	amidase activity
MID01_RS03595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MID01_RS03605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MID01_RS03610	COG1597	lipid kinase activity
MID01_RS03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MID01_RS03630	COG5444	nuclease activity
MID01_RS03635	COG3391	amine dehydrogenase activity
MID01_RS03640	COG0457	Tetratricopeptide repeat
MID01_RS03650	COG0217	transcriptional regulatory protein
MID01_RS03660	COG1309	transcriptional regulator
MID01_RS03665	COG3631	Ketosteroid isomerase-related protein
MID01_RS03685	COG3546	catalase activity
MID01_RS03690	COG0454	-acetyltransferase
MID01_RS03700	COG5578	integral membrane protein
MID01_RS03705	COG2972	Histidine kinase
MID01_RS03710	COG4753	response regulator
MID01_RS03710	COG2207	Transcriptional regulator
MID01_RS03715	COG1653	transport
MID01_RS03720	COG1175	transmembrane transport
MID01_RS03725	COG0395	ABC-type sugar transport system, permease component
MID01_RS03730	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MID01_RS03735	COG2207	Transcriptional regulator
MID01_RS03740	COG2755	lipolytic protein G-D-S-L family
MID01_RS03750	COG5578	integral membrane protein
MID01_RS03755	COG3401	FG-GAP repeat protein
MID01_RS03760	COG3401	FG-GAP repeat protein
MID01_RS03765	COG2755	lipolytic protein G-D-S-L family
MID01_RS03770	COG1874	Beta-galactosidase
MID01_RS03780	COG1653	transport
MID01_RS03785	COG4209	transmembrane transport
MID01_RS03790	COG0395	ABC-type sugar transport system, permease component
MID01_RS03795	COG1486	melibiose metabolic process
MID01_RS03800	COG2323	membrane
MID01_RS03805	COG2329	Antibiotic biosynthesis monooxygenase
MID01_RS03810	COG0346	lactoylglutathione lyase activity
MID01_RS03825	COG5583	Uncharacterized small protein (DUF2292)
MID01_RS03830	COG0670	Belongs to the BI1 family
MID01_RS03835	COG0697	spore germination
MID01_RS03840	COG1846	Transcriptional regulator
MID01_RS03845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID01_RS03865	COG1368	sulfuric ester hydrolase activity
MID01_RS03870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MID01_RS03875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID01_RS03880	COG1442	glycosyl transferase family 8
MID01_RS03885	COG1216	Glycosyl transferase, family 2
MID01_RS03890	COG1442	glycosyl transferase family 8
MID01_RS03895	COG2223	nitrite transmembrane transporter activity
MID01_RS03900	COG1011	Hydrolase
MID01_RS03905	COG0531	amino acid
MID01_RS03910	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS03915	COG0840	transmembrane signaling receptor activity
MID01_RS03920	COG0488	(ABC) transporter
MID01_RS03930	COG0789	Transcriptional regulator
MID01_RS03935	COG2814	Major facilitator Superfamily
MID01_RS03940	COG1404	Belongs to the peptidase S8 family
MID01_RS03960	COG0488	(ABC) transporter
MID01_RS03965	COG0513	Belongs to the DEAD box helicase family
MID01_RS03970	COG0456	acetyltransferase
MID01_RS03975	COG2130	NADP-dependent
MID01_RS03980	COG1120	ATPase activity
MID01_RS03985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS03995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MID01_RS04010	COG3866	Pectate lyase
MID01_RS04015	COG0471	metal ion transport
MID01_RS04020	COG3290	protein histidine kinase activity
MID01_RS04025	COG4565	transcriptional regulatory protein
MID01_RS04030	COG3181	Tripartite tricarboxylate transporter family receptor
MID01_RS04035	COG2851	Citrate transporter
MID01_RS04040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS04045	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MID01_RS04050	COG1254	Belongs to the acylphosphatase family
MID01_RS04055	COG2258	MOSC domain
MID01_RS04075	COG0024	Methionine aminopeptidase
MID01_RS04080	COG1263	PTS System
MID01_RS04080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS04085	COG1368	sulfuric ester hydrolase activity
MID01_RS04100	COG1115	amino acid carrier protein
MID01_RS04105	COG0531	amino acid
MID01_RS04120	COG0697	spore germination
MID01_RS04125	COG1263	PTS System
MID01_RS04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS04130	COG0366	Alpha amylase catalytic
MID01_RS04135	COG2188	Transcriptional regulator
MID01_RS04140	COG0778	Nitroreductase
MID01_RS04145	COG0737	Belongs to the 5'-nucleotidase family
MID01_RS04150	COG0693	protein deglycase activity
MID01_RS04155	COG2814	Major facilitator Superfamily
MID01_RS04160	COG4840	Belongs to the UPF0435 family
MID01_RS04165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MID01_RS04170	COG4980	gas vesicle protein
MID01_RS04175	COG1295	ribonuclease BN
MID01_RS04180	COG0477	Major facilitator Superfamily
MID01_RS04185	COG0387	Pfam Sodium calcium exchanger
MID01_RS04195	COG0668	transmembrane transport
MID01_RS04200	COG0535	radical SAM domain protein
MID01_RS04210	COG0726	polysaccharide deacetylase
MID01_RS04215	COG2084	Dehydrogenase
MID01_RS04220	COG0598	Magnesium transport protein CorA
MID01_RS04225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MID01_RS04230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MID01_RS04240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MID01_RS04245	COG4637	Psort location Cytoplasmic, score
MID01_RS04255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MID01_RS04260	COG0022	dehydrogenase e1 component
MID01_RS04265	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID01_RS04270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID01_RS04275	COG3284	Transcriptional regulator
MID01_RS04285	COG1742	UPF0060 membrane protein
MID01_RS04310	COG4842	Belongs to the WXG100 family
MID01_RS04315	COG1486	melibiose metabolic process
MID01_RS04320	COG1737	Transcriptional regulator
MID01_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS04325	COG1263	PTS System
MID01_RS04330	COG5434	Belongs to the glycosyl hydrolase 28 family
MID01_RS04335	COG1132	(ABC) transporter
MID01_RS04340	COG1132	(ABC) transporter
MID01_RS04345	COG2259	Doxx family
MID01_RS04350	COG2514	catechol 2,3-dioxygenase activity
MID01_RS04355	COG4585	Histidine kinase
MID01_RS04360	COG2197	response regulator
MID01_RS04365	COG1131	(ABC) transporter
MID01_RS04370	COG0842	Transport permease protein
MID01_RS04370	COG1511	domain protein
MID01_RS04375	COG0842	Transport permease protein
MID01_RS04380	COG1695	Transcriptional regulator
MID01_RS04385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MID01_RS04390	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MID01_RS04395	COG2318	DinB family
MID01_RS04400	COG2814	Major facilitator Superfamily
MID01_RS04405	COG1846	Transcriptional regulator
MID01_RS04410	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MID01_RS04410	COG0392	lysyltransferase activity
MID01_RS04415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS04420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS04425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS04430	COG0384	phenazine biosynthesis protein PhzF
MID01_RS04435	COG0778	Nitroreductase
MID01_RS04450	COG1090	epimerase
MID01_RS04455	COG2137	regulation of response to DNA damage stimulus
MID01_RS04465	COG2814	Major facilitator Superfamily
MID01_RS04480	COG3103	Sh3 type 3 domain protein
MID01_RS04485	COG5658	integral membrane protein
MID01_RS04490	COG0596	Alpha beta hydrolase
MID01_RS04495	COG0463	Glycosyl transferase, family 2
MID01_RS04500	COG4485	Bacterial membrane protein, YfhO
MID01_RS04505	COG1988	membrane-bound metal-dependent
MID01_RS04510	COG1194	a g-specific adenine glycosylase
MID01_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS04535	COG3557	Belongs to the UPF0374 family
MID01_RS04540	COG1132	(ABC) transporter
MID01_RS04545	COG4129	membrane
MID01_RS04550	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MID01_RS04555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MID01_RS04560	COG0735	belongs to the Fur family
MID01_RS04670	COG4326	sporulation control protein
MID01_RS04680	COG5577	PFAM Coat F domain
MID01_RS04690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MID01_RS04705	COG0753	catalase activity
MID01_RS04710	COG1116	anion transmembrane transporter activity
MID01_RS04715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MID01_RS04720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID01_RS04725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS04735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MID01_RS04745	COG1476	TRANSCRIPTIONal
MID01_RS04755	COG3382	B3 4 domain protein
MID01_RS04760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MID01_RS04770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MID01_RS04775	COG0789	Transcriptional regulator
MID01_RS04780	COG1664	Polymer-forming cytoskeletal
MID01_RS04785	COG1664	Polymer-forming cytoskeletal
MID01_RS04790	COG2766	serine protein kinase
MID01_RS04795	COG2718	Belongs to the UPF0229 family
MID01_RS04800	COG1846	Transcriptional regulator
MID01_RS04805	COG1566	PFAM secretion protein HlyD family protein
MID01_RS04810	COG2814	Major facilitator Superfamily
MID01_RS04815	COG0655	NAD(P)H dehydrogenase (quinone) activity
MID01_RS04835	COG1725	Transcriptional regulator
MID01_RS04840	COG1131	(ABC) transporter
MID01_RS04845	COG1131	(ABC) transporter
MID01_RS04850	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MID01_RS04855	COG1278	Cold shock
MID01_RS04860	COG1464	Belongs to the NlpA lipoprotein family
MID01_RS04865	COG3706	GGDEF domain
MID01_RS04870	COG1823	symporter activity
MID01_RS04900	COG5577	PFAM Coat F domain
MID01_RS04905	COG0737	Belongs to the 5'-nucleotidase family
MID01_RS04905	COG1525	nuclease
MID01_RS04905	COG4085	toxin activity
MID01_RS04910	COG3764	Sortase (surface protein transpeptidase)
MID01_RS04915	COG0564	pseudouridine synthase activity
MID01_RS04925	COG0517	IMP dehydrogenase activity
MID01_RS04930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID01_RS04935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID01_RS04935	COG3153	acetyltransferase
MID01_RS04940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MID01_RS04945	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MID01_RS04950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MID01_RS04955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MID01_RS04960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MID01_RS04965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MID01_RS04970	COG2203	Gaf domain
MID01_RS04970	COG4585	Histidine kinase
MID01_RS04975	COG2197	response regulator
MID01_RS04980	COG0431	NADPH-dependent FMN reductase
MID01_RS04995	COG0791	NLP P60 protein
MID01_RS04995	COG1388	LysM domain
MID01_RS05000	COG1959	2 iron, 2 sulfur cluster binding
MID01_RS05005	COG0668	transmembrane transport
MID01_RS05010	COG2719	SpoVR family
MID01_RS05015	COG1785	Belongs to the alkaline phosphatase family
MID01_RS05020	COG0791	NLP P60 protein
MID01_RS05020	COG1388	LysM domain
MID01_RS05025	COG0583	DNA-binding transcription factor activity
MID01_RS05030	COG0372	Belongs to the citrate synthase family
MID01_RS05035	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS05040	COG0531	amino acid
MID01_RS05045	COG0733	neurotransmitter:sodium symporter activity
MID01_RS05050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS05055	COG0456	acetyltransferase
MID01_RS05070	COG1595	DNA-templated transcription, initiation
MID01_RS05075	COG0667	Aldo Keto reductase
MID01_RS05080	COG0204	Acyl-transferase
MID01_RS05085	COG1253	flavin adenine dinucleotide binding
MID01_RS05090	COG0789	Transcriptional regulator
MID01_RS05095	COG0436	Aminotransferase
MID01_RS05100	COG1253	flavin adenine dinucleotide binding
MID01_RS05105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MID01_RS05110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MID01_RS05115	COG0584	glycerophosphoryl diester phosphodiesterase
MID01_RS05125	COG0668	transmembrane transport
MID01_RS05130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MID01_RS05135	COG0726	polysaccharide deacetylase
MID01_RS05140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MID01_RS05145	COG1757	Na H antiporter
MID01_RS05150	COG0589	response to stress
MID01_RS05160	COG1132	(ABC) transporter
MID01_RS05165	COG1132	(ABC) transporter
MID01_RS05170	COG0702	epimerase
MID01_RS05190	COG0189	ligase activity
MID01_RS05195	COG0189	ligase activity
MID01_RS05200	COG4399	Belongs to the UPF0754 family
MID01_RS05205	COG3679	Belongs to the UPF0342 family
MID01_RS05210	COG4335	DNA alkylation repair
MID01_RS05215	COG0561	phosphatase activity
MID01_RS05220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MID01_RS05225	COG0475	glutathione-regulated potassium exporter activity
MID01_RS05230	COG0490	domain, Protein
MID01_RS05240	COG1024	Enoyl-CoA hydratase
MID01_RS05250	COG4152	abc transporter atp-binding protein
MID01_RS05255	COG1668	transmembrane transport
MID01_RS05260	COG0420	3'-5' exonuclease activity
MID01_RS05265	COG4717	serine-type aminopeptidase activity
MID01_RS05270	COG3481	metal-dependent phosphohydrolase, HD sub domain
MID01_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MID01_RS05310	COG1846	Transcriptional regulator
MID01_RS05315	COG4980	gas vesicle protein
MID01_RS05330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MID01_RS05335	COG0537	adenosine 5'-monophosphoramidase activity
MID01_RS05340	COG1131	(ABC) transporter
MID01_RS05345	COG4473	ABC transporter
MID01_RS05355	COG1473	amidohydrolase
MID01_RS05360	COG3069	C4-dicarboxylate transmembrane transporter activity
MID01_RS05370	COG2329	Antibiotic biosynthesis monooxygenase
MID01_RS05375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID01_RS05380	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MID01_RS05385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MID01_RS05390	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MID01_RS05395	COG1309	transcriptional regulator
MID01_RS05400	COG1511	domain protein
MID01_RS05405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MID01_RS05410	COG4377	Putative membrane peptidase family (DUF2324)
MID01_RS05420	COG1363	Peptidase, m42
MID01_RS05425	COG4405	Protein conserved in bacteria
MID01_RS05430	COG1301	dicarboxylic acid transport
MID01_RS05440	COG1234	tRNA 3'-trailer cleavage
MID01_RS05445	COG0095	Lipoate-protein ligase
MID01_RS05450	COG0702	epimerase
MID01_RS05455	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS05465	COG0501	Belongs to the peptidase M48B family
MID01_RS05475	COG0456	acetyltransferase
MID01_RS05480	COG0604	alcohol dehydrogenase
MID01_RS05485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MID01_RS05490	COG0406	alpha-ribazole phosphatase activity
MID01_RS05495	COG0183	Belongs to the thiolase family
MID01_RS05500	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS05505	COG1268	BioY protein
MID01_RS05510	COG0840	transmembrane signaling receptor activity
MID01_RS05515	COG0723	plastoquinol--plastocyanin reductase activity
MID01_RS05515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID01_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS05530	COG4903	ComK protein
MID01_RS05535	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS05545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID01_RS05560	COG0398	Pfam SNARE associated Golgi protein
MID01_RS05565	COG0681	Belongs to the peptidase S26 family
MID01_RS05570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MID01_RS05575	COG1846	Transcriptional regulator
MID01_RS05585	COG0738	Major facilitator superfamily
MID01_RS05590	COG0673	inositol 2-dehydrogenase activity
MID01_RS05595	COG0561	phosphatase activity
MID01_RS05600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MID01_RS05605	COG1609	Transcriptional regulator
MID01_RS05610	COG3180	Ammonia monooxygenase
MID01_RS05615	COG0477	Major facilitator Superfamily
MID01_RS05615	COG2814	Major facilitator Superfamily
MID01_RS05620	COG4533	DNA binding
MID01_RS05630	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MID01_RS05635	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MID01_RS05640	COG1074	ATP-dependent DNA helicase activity
MID01_RS05645	COG0420	3'-5' exonuclease activity
MID01_RS05650	COG0419	ATPase involved in DNA repair
MID01_RS05655	COG1403	HNH endonuclease
MID01_RS05695	COG5337	Spore coat protein CotH
MID01_RS05700	COG0179	Fumarylacetoacetate (FAA) hydrolase
MID01_RS05710	COG1404	Belongs to the peptidase S8 family
MID01_RS05720	COG0367	asparagine synthase
MID01_RS05725	COG2318	DinB family
MID01_RS05735	COG0534	Mate efflux family protein
MID01_RS05740	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS05740	COG2207	Transcriptional regulator
MID01_RS05745	COG1609	Transcriptional regulator
MID01_RS05750	COG0673	inositol 2-dehydrogenase activity
MID01_RS05755	COG2318	DinB family
MID01_RS05760	COG1279	arginine transmembrane transporter activity
MID01_RS05765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MID01_RS05770	COG1357	PFAM Pentapeptide repeats (8 copies)
MID01_RS05775	COG2267	carboxylic ester hydrolase activity
MID01_RS05780	COG0529	Catalyzes the synthesis of activated sulfate
MID01_RS05785	COG2046	Belongs to the sulfate adenylyltransferase family
MID01_RS05790	COG0175	sulfate reduction
MID01_RS05795	COG2045	Belongs to the ComB family
MID01_RS05800	COG1809	phosphosulfolactate synthase activity
MID01_RS05805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS05810	COG4948	Mandelate Racemase Muconate Lactonizing
MID01_RS05815	COG2814	Major facilitator Superfamily
MID01_RS05820	COG0454	-acetyltransferase
MID01_RS05825	COG2153	protein acetylation
MID01_RS05830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MID01_RS05830	COG0646	methionine synthase
MID01_RS05835	COG1666	GTP binding
MID01_RS05860	COG1695	Transcriptional regulator
MID01_RS05875	COG3227	Zinc metalloprotease (Elastase)
MID01_RS05880	COG1307	EDD domain protein, DegV family
MID01_RS05885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS05905	COG0561	phosphatase activity
MID01_RS05910	COG1073	alpha beta
MID01_RS05915	COG2151	metal-sulfur cluster biosynthetic enzyme
MID01_RS05925	COG0277	FAD linked oxidase domain protein
MID01_RS05930	COG2271	Major facilitator Superfamily
MID01_RS05935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MID01_RS05940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MID01_RS05950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MID01_RS05955	COG0505	Belongs to the CarA family
MID01_RS05960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MID01_RS05965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MID01_RS05980	COG2267	carboxylic ester hydrolase activity
MID01_RS05990	COG1744	ABC transporter substrate-binding protein PnrA-like
MID01_RS06005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MID01_RS06010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MID01_RS06015	COG5504	Zn-dependent protease
MID01_RS06020	COG0444	Belongs to the ABC transporter superfamily
MID01_RS06025	COG4608	Belongs to the ABC transporter superfamily
MID01_RS06035	COG0601	transmembrane transport
MID01_RS06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID01_RS06050	COG0180	Tryptophanyl-tRNA synthetase
MID01_RS06055	COG4166	transmembrane transport
MID01_RS06060	COG0601	transmembrane transport
MID01_RS06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID01_RS06070	COG0444	Belongs to the ABC transporter superfamily
MID01_RS06075	COG4608	Belongs to the ABC transporter superfamily
MID01_RS06080	COG2814	Major facilitator Superfamily
MID01_RS06085	COG0456	acetyltransferase
MID01_RS06090	COG1393	Belongs to the ArsC family
MID01_RS06095	COG0861	Integral membrane protein TerC family
MID01_RS06105	COG4862	establishment of competence for transformation
MID01_RS06115	COG4469	Competence protein
MID01_RS06120	COG1164	Oligoendopeptidase f
MID01_RS06130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MID01_RS06135	COG2346	COG2346, Truncated hemoglobins
MID01_RS06140	COG0741	lytic transglycosylase activity
MID01_RS06145	COG4116	CYTH
MID01_RS06155	COG2357	RelA SpoT domain protein
MID01_RS06160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MID01_RS06165	COG0564	pseudouridine synthase activity
MID01_RS06170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MID01_RS06175	COG0569	domain protein
MID01_RS06175	COG0475	glutathione-regulated potassium exporter activity
MID01_RS06180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MID01_RS06185	COG0352	thiamine-phosphate diphosphorylase activity
MID01_RS06190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID01_RS06195	COG2104	thiamine diphosphate biosynthetic process
MID01_RS06200	COG2022	thiamine diphosphate biosynthetic process
MID01_RS06205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MID01_RS06210	COG0351	phosphomethylpyrimidine kinase
MID01_RS06215	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MID01_RS06270	COG0210	DNA helicase
MID01_RS06280	COG2153	protein acetylation
MID01_RS06285	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MID01_RS06290	COG2382	esterase
MID01_RS06295	COG0626	cystathionine gamma-synthase activity
MID01_RS06300	COG0626	cystathionine gamma-synthase activity
MID01_RS06305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS06310	COG5505	Protein of unknown function (DUF819)
MID01_RS06325	COG5444	nuclease activity
MID01_RS06375	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MID01_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS06390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS06390	COG3711	transcriptional antiterminator
MID01_RS06395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS06395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MID01_RS06395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MID01_RS06400	COG1482	cell wall glycoprotein biosynthetic process
MID01_RS06410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS06420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MID01_RS06435	COG0109	protoheme IX farnesyltransferase activity
MID01_RS06445	COG0726	polysaccharide deacetylase
MID01_RS06460	COG5504	Zn-dependent protease
MID01_RS06465	COG2205	protein histidine kinase activity
MID01_RS06475	COG3383	formate dehydrogenase (NAD+) activity
MID01_RS06480	COG2427	Protein of unknown function (DUF1641)
MID01_RS06490	COG1051	belongs to the nudix hydrolase family
MID01_RS06500	COG2124	cytochrome p450
MID01_RS06505	COG1819	glycosyl
MID01_RS06525	COG1587	Uroporphyrinogen-III synthase
MID01_RS06530	COG0390	transport system, permease component
MID01_RS06535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MID01_RS06540	COG0697	spore germination
MID01_RS06545	COG4297	protein containing double-stranded beta helix domain
MID01_RS06555	COG1252	NADH dehydrogenase
MID01_RS06560	COG1904	glucuronate isomerase
MID01_RS06565	COG2211	Major facilitator Superfamily
MID01_RS06570	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MID01_RS06575	COG1063	alcohol dehydrogenase
MID01_RS06580	COG1312	Catalyzes the dehydration of D-mannonate
MID01_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS06590	COG2271	Major facilitator Superfamily
MID01_RS06595	COG1609	Transcriptional regulator
MID01_RS06600	COG0246	Mannitol dehydrogenase
MID01_RS06605	COG2721	sulfolactate sulfo-lyase activity
MID01_RS06610	COG0730	response to heat
MID01_RS06615	COG2318	DinB family
MID01_RS06620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MID01_RS06625	COG0457	Tetratricopeptide repeat
MID01_RS06635	COG2350	Protein conserved in bacteria
MID01_RS06640	COG5632	N-Acetylmuramoyl-L-alanine amidase
MID01_RS06640	COG1388	LysM domain
MID01_RS06640	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS06650	COG4195	phage-related replication protein
MID01_RS06655	COG3546	catalase activity
MID01_RS06660	COG2856	Zn peptidase
MID01_RS06665	COG1396	sequence-specific DNA binding
MID01_RS06675	COG1522	sequence-specific DNA binding
MID01_RS06680	COG1484	DNA-dependent DNA replication
MID01_RS06700	COG1595	DNA-templated transcription, initiation
MID01_RS06705	COG5484	DNA packaging
MID01_RS06705	COG3728	DNA packaging
MID01_RS06710	COG1783	phage Terminase large subunit
MID01_RS06715	COG5518	Phage portal protein
MID01_RS06720	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MID01_RS06725	COG4653	Phage capsid family
MID01_RS06775	COG5412	phage tail tape measure protein
MID01_RS06775	COG3953	SLT domain
MID01_RS06780	COG1652	LysM domain
MID01_RS06785	COG4193	domain, Protein
MID01_RS06795	COG3628	GPW Gp25 family protein
MID01_RS06800	COG3299	homolog of phage Mu protein gp47
MID01_RS06805	COG3778	Protein conserved in bacteria
MID01_RS06845	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS06845	COG5632	N-Acetylmuramoyl-L-alanine amidase
MID01_RS06865	COG0306	phosphate transporter
MID01_RS06870	COG1392	Phosphate transport regulator
MID01_RS06875	COG0531	amino acid
MID01_RS06880	COG0346	lactoylglutathione lyase activity
MID01_RS06890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MID01_RS06895	COG0463	Glycosyl transferase, family 2
MID01_RS06905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID01_RS06910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MID01_RS06915	COG2362	D-Aminopeptidase
MID01_RS06920	COG0601	transmembrane transport
MID01_RS06925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MID01_RS06930	COG0444	Belongs to the ABC transporter superfamily
MID01_RS06935	COG4166	transmembrane transport
MID01_RS06940	COG1619	proteins homologs of microcin C7 resistance protein MccF
MID01_RS06945	COG4948	Mandelate Racemase Muconate Lactonizing
MID01_RS06950	COG0791	NLP P60 protein
MID01_RS06955	COG4608	Belongs to the ABC transporter superfamily
MID01_RS06960	COG2706	6-phosphogluconolactonase activity
MID01_RS06965	COG1834	amidinotransferase
MID01_RS06970	COG1607	acyl-coa hydrolase
MID01_RS06975	COG1017	nitric oxide dioxygenase activity
MID01_RS06975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MID01_RS06985	COG2323	membrane
MID01_RS06990	COG2318	DinB family
MID01_RS06995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS07000	COG2076	Multidrug Resistance protein
MID01_RS07005	COG2076	Multidrug Resistance protein
MID01_RS07010	COG0788	formyltetrahydrofolate deformylase activity
MID01_RS07015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MID01_RS07020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MID01_RS07025	COG1764	response to oxidative stress
MID01_RS07030	COG1846	Transcriptional regulator
MID01_RS07035	COG1764	response to oxidative stress
MID01_RS07045	COG0590	tRNA wobble adenosine to inosine editing
MID01_RS07050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MID01_RS07055	COG1404	Belongs to the peptidase S8 family
MID01_RS07060	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS07065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MID01_RS07070	COG1122	ATPase activity
MID01_RS07075	COG4721	ABC-type cobalt transport system, permease component
MID01_RS07085	COG0745	RESPONSE REGULATOR receiver
MID01_RS07090	COG5002	protein histidine kinase activity
MID01_RS07090	COG3850	Histidine kinase
MID01_RS07095	COG3212	peptidase
MID01_RS07100	COG3212	peptidase
MID01_RS07110	COG2239	Acts as a magnesium transporter
MID01_RS07115	COG0789	Transcriptional regulator
MID01_RS07130	COG1846	Transcriptional regulator
MID01_RS07135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MID01_RS07140	COG0726	polysaccharide deacetylase
MID01_RS07145	COG1408	metallophosphoesterase
MID01_RS07155	COG0463	Glycosyl transferase, family 2
MID01_RS07160	COG1793	dna ligase
MID01_RS07160	COG3285	dna ligase
MID01_RS07165	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MID01_RS07170	COG5001	Diguanylate cyclase
MID01_RS07170	COG3300	MHYT domain
MID01_RS07175	COG0586	Pfam SNARE associated Golgi protein
MID01_RS07180	COG0861	Integral membrane protein TerC family
MID01_RS07185	COG1191	sigma factor activity
MID01_RS07205	COG0501	Belongs to the peptidase M48B family
MID01_RS07210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MID01_RS07225	COG3594	Acyltransferase
MID01_RS07230	COG5002	protein histidine kinase activity
MID01_RS07235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MID01_RS07245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MID01_RS07250	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MID01_RS07255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MID01_RS07260	COG0436	Aminotransferase
MID01_RS07265	COG1850	ribulose-bisphosphate carboxylase activity
MID01_RS07270	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MID01_RS07275	COG0235	Class ii aldolase
MID01_RS07280	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MID01_RS07285	COG3339	Conserved Protein
MID01_RS07300	COG3852	Histidine kinase
MID01_RS07305	COG1846	Transcriptional regulator
MID01_RS07310	COG1360	Flagellar Motor Protein
MID01_RS07315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MID01_RS07320	COG0542	response to heat
MID01_RS07325	COG3949	Membrane
MID01_RS07330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MID01_RS07335	COG0720	synthase
MID01_RS07340	COG0602	queuosine metabolic process
MID01_RS07345	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MID01_RS07350	COG1733	regulation of RNA biosynthetic process
MID01_RS07355	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS07360	COG4641	Protein conserved in bacteria
MID01_RS07360	COG1388	LysM domain
MID01_RS07365	COG1388	LysM domain
MID01_RS07370	COG3858	chitin binding
MID01_RS07380	COG4873	Protein conserved in bacteria
MID01_RS07390	COG3773	Cell wall hydrolase
MID01_RS07395	COG2244	polysaccharide biosynthetic process
MID01_RS07400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS07405	COG2217	Heavy metal translocating P-type atpase
MID01_RS07415	COG0006	proline dipeptidase activity
MID01_RS07420	COG1609	Transcriptional regulator
MID01_RS07425	COG3711	transcriptional antiterminator
MID01_RS07430	COG2190	(PTS) system
MID01_RS07430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS07430	COG1263	PTS System
MID01_RS07435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS07440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MID01_RS07450	COG1533	DNA photolyase activity
MID01_RS07455	COG0456	acetyltransferase
MID01_RS07460	COG0840	transmembrane signaling receptor activity
MID01_RS07465	COG2084	Dehydrogenase
MID01_RS07470	COG4257	antibiotic catabolic process
MID01_RS07475	COG2340	Cysteine-rich secretory protein family
MID01_RS07480	COG0768	penicillin binding
MID01_RS07485	COG4191	Histidine kinase
MID01_RS07490	COG0436	Aminotransferase
MID01_RS07500	COG0784	Response regulator, receiver
MID01_RS07500	COG0835	chemotaxis
MID01_RS07510	COG2814	Major facilitator Superfamily
MID01_RS07515	COG1376	ErfK ybiS ycfS ynhG family protein
MID01_RS07520	COG1408	metallophosphoesterase
MID01_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS07530	COG2200	EAL domain
MID01_RS07535	COG4703	Protein of unknown function (DUF1797)
MID01_RS07540	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MID01_RS07550	COG0517	IMP dehydrogenase activity
MID01_RS07555	COG0583	DNA-binding transcription factor activity
MID01_RS07560	COG0716	FMN binding
MID01_RS07570	COG0716	FMN binding
MID01_RS07575	COG2171	N-acyltransferase activity
MID01_RS07580	COG1473	amidohydrolase
MID01_RS07590	COG0668	transmembrane transport
MID01_RS07595	COG0450	alkyl hydroperoxide reductase
MID01_RS07600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS07615	COG0746	molybdenum cofactor guanylyltransferase activity
MID01_RS07620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MID01_RS07625	COG0303	'Molybdopterin
MID01_RS07630	COG1763	Mo-molybdopterin cofactor biosynthetic process
MID01_RS07635	COG0314	molybdopterin synthase activity
MID01_RS07640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MID01_RS07645	COG1132	(ABC) transporter
MID01_RS07650	COG1132	(ABC) transporter
MID01_RS07660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID01_RS07665	COG1136	(ABC) transporter
MID01_RS07670	COG0577	efflux transmembrane transporter activity
MID01_RS07675	COG1349	DNA-binding transcription factor activity
MID01_RS07680	COG1105	Belongs to the carbohydrate kinase PfkB family
MID01_RS07685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS07685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MID01_RS07685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MID01_RS07690	COG0681	Belongs to the peptidase S26 family
MID01_RS07700	COG0488	(ABC) transporter
MID01_RS07705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MID01_RS07710	COG2309	aminopeptidase activity
MID01_RS07720	COG1077	Cell shape determining protein MreB Mrl
MID01_RS07725	COG2002	toxin-antitoxin pair type II binding
MID01_RS07730	COG3852	Histidine kinase
MID01_RS07735	COG2105	PFAM AIG2 family protein
MID01_RS07735	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MID01_RS07740	COG0569	domain protein
MID01_RS07745	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MID01_RS07750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MID01_RS07755	COG5503	Protein of unknown function (DUF1447)
MID01_RS07760	COG0561	phosphatase activity
MID01_RS07765	COG0242	peptide deformylase activity
MID01_RS07775	COG0497	DNA recombination
MID01_RS07780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MID01_RS07785	COG0022	dehydrogenase e1 component
MID01_RS07790	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID01_RS07795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID01_RS07800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS07810	COG1982	Orn Lys Arg decarboxylase major
MID01_RS07815	COG4476	Belongs to the UPF0223 family
MID01_RS07820	COG4493	Belongs to the UPF0637 family
MID01_RS07830	COG0483	inositol monophosphate 1-phosphatase activity
MID01_RS07840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MID01_RS07880	COG1217	gtp-binding protein TYPA
MID01_RS07890	COG4896	Protein conserved in bacteria
MID01_RS07900	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MID01_RS07905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MID01_RS07910	COG2066	Belongs to the glutaminase family
MID01_RS07915	COG4838	Belongs to the UPF0358 family
MID01_RS07920	COG0772	Belongs to the SEDS family
MID01_RS07925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MID01_RS07930	COG1612	heme a metabolic process
MID01_RS07935	COG0109	protoheme IX farnesyltransferase activity
MID01_RS07940	COG2010	Cytochrome c
MID01_RS07940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MID01_RS07945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MID01_RS07950	COG1845	cytochrome c oxidase, subunit III
MID01_RS07955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MID01_RS07960	COG3336	cytochrome c oxidase
MID01_RS07970	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MID01_RS07975	COG2340	Cysteine-rich secretory protein family
MID01_RS07990	COG3679	Belongs to the UPF0342 family
MID01_RS07995	COG4471	UPF0298 protein
MID01_RS08000	COG0742	ribosomal rna small subunit methyltransferase
MID01_RS08005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MID01_RS08010	COG3314	Sporulation integral membrane protein YlbJ
MID01_RS08015	COG1752	Esterase of the alpha-beta hydrolase superfamily
MID01_RS08020	COG3480	Lon protease (S16) C-terminal proteolytic domain
MID01_RS08025	COG1323	Belongs to the UPF0348 family
MID01_RS08035	COG1399	metal-binding, possibly nucleic acid-binding protein
MID01_RS08050	COG0454	-acetyltransferase
MID01_RS08055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MID01_RS08060	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MID01_RS08065	COG2001	Belongs to the MraZ family
MID01_RS08070	COG0275	rRNA processing
MID01_RS08075	COG4839	cell division protein FtsL
MID01_RS08080	COG0768	penicillin binding
MID01_RS08085	COG0768	penicillin binding
MID01_RS08090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MID01_RS08095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MID01_RS08100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MID01_RS08105	COG0772	Belongs to the SEDS family
MID01_RS08110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MID01_RS08115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MID01_RS08120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MID01_RS08125	COG3879	Bacterial protein of unknown function (DUF881)
MID01_RS08130	COG3879	Bacterial protein of unknown function (DUF881)
MID01_RS08135	COG3856	small basic protein
MID01_RS08140	COG0849	cell division
MID01_RS08145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MID01_RS08150	COG1404	Belongs to the peptidase S8 family
MID01_RS08150	COG4412	M6 family metalloprotease domain protein
MID01_RS08160	COG1191	sigma factor activity
MID01_RS08165	COG1191	sigma factor activity
MID01_RS08170	COG1119	ATPase activity
MID01_RS08175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID01_RS08180	COG1873	PFAM PRC-barrel domain
MID01_RS08185	COG1496	oxidoreductase activity
MID01_RS08190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MID01_RS08195	COG1799	cell septum assembly
MID01_RS08200	COG0762	integral membrane protein
MID01_RS08205	COG2302	S4 RNA-binding domain
MID01_RS08210	COG3599	regulation of cell shape
MID01_RS08215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MID01_RS08220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MID01_RS08225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MID01_RS08230	COG0564	pseudouridine synthase activity
MID01_RS08235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MID01_RS08240	COG2233	PERMEase
MID01_RS08245	COG0540	Belongs to the ATCase OTCase family
MID01_RS08250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MID01_RS08255	COG0505	Belongs to the CarA family
MID01_RS08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MID01_RS08265	COG0543	2 iron, 2 sulfur cluster binding
MID01_RS08270	COG0167	dihydroorotate dehydrogenase activity
MID01_RS08275	COG0284	orotidine-5'-phosphate decarboxylase activity
MID01_RS08280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MID01_RS08285	COG0175	sulfate reduction
MID01_RS08290	COG0306	phosphate transporter
MID01_RS08295	COG2046	Belongs to the sulfate adenylyltransferase family
MID01_RS08300	COG0529	Catalyzes the synthesis of activated sulfate
MID01_RS08305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MID01_RS08310	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
MID01_RS08315	COG1648	precorrin-2 dehydrogenase activity
MID01_RS08320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MID01_RS08325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MID01_RS08330	COG1561	YicC-like family, N-terminal region
MID01_RS08340	COG0194	GDP metabolic process
MID01_RS08345	COG1758	RNA polymerase activity
MID01_RS08350	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MID01_RS08355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MID01_RS08360	COG0242	peptide deformylase activity
MID01_RS08365	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MID01_RS08370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MID01_RS08370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MID01_RS08375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MID01_RS08380	COG0631	protein serine/threonine phosphatase activity
MID01_RS08385	COG2815	serine threonine protein kinase
MID01_RS08385	COG0515	serine threonine protein kinase
MID01_RS08390	COG1162	GTPase activity
MID01_RS08395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MID01_RS08400	COG1564	THIamine pyrophosphokinase
MID01_RS08410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MID01_RS08415	COG1302	Protein conserved in bacteria
MID01_RS08420	COG1461	Dihydroxyacetone kinase
MID01_RS08425	COG1760	l-serine dehydratase
MID01_RS08430	COG1760	l-serine dehydratase
MID01_RS08435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MID01_RS08440	COG2050	protein possibly involved in aromatic compounds catabolism
MID01_RS08440	COG1349	DNA-binding transcription factor activity
MID01_RS08445	COG0416	fatty acid biosynthetic process
MID01_RS08450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MID01_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS08465	COG0571	ribonuclease III activity
MID01_RS08470	COG1196	nuclear chromosome segregation
MID01_RS08475	COG0552	protein localization to endoplasmic reticulum
MID01_RS08485	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MID01_RS08490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MID01_RS08495	COG0228	four-way junction DNA binding
MID01_RS08500	COG1837	Belongs to the UPF0109 family
MID01_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MID01_RS08515	COG0336	Belongs to the RNA methyltransferase TrmD family
MID01_RS08520	COG0335	large ribosomal subunit rRNA binding
MID01_RS08525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MID01_RS08530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MID01_RS08540	COG2257	FlhB HrpN YscU SpaS Family
MID01_RS08545	COG0045	succinate-CoA ligase (ADP-forming) activity
MID01_RS08550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MID01_RS08555	COG0758	DNA mediated transformation
MID01_RS08560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MID01_RS08565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MID01_RS08570	COG4974	Belongs to the 'phage' integrase family
MID01_RS08575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MID01_RS08580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MID01_RS08585	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MID01_RS08590	COG1815	bacterial-type flagellum-dependent cell motility
MID01_RS08595	COG1558	bacterial-type flagellum-dependent cell motility
MID01_RS08600	COG1677	Flagellar hook-basal body complex protein FliE
MID01_RS08605	COG1766	The M ring may be actively involved in energy transduction
MID01_RS08610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MID01_RS08615	COG1317	bacterial-type flagellum organization
MID01_RS08620	COG1157	protein secretion by the type III secretion system
MID01_RS08625	COG2882	bacterial-type flagellum organization
MID01_RS08630	COG3334	PFAM MgtE intracellular
MID01_RS08635	COG3144	bacterial-type flagellum assembly
MID01_RS08640	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MID01_RS08645	COG4786	Flagellar basal body rod
MID01_RS08650	COG1582	Flagellar protein (FlbD)
MID01_RS08655	COG1580	Controls the rotational direction of flagella during chemotaxis
MID01_RS08660	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MID01_RS08670	COG2201	protein-glutamate methylesterase activity
MID01_RS08675	COG3190	flagellar
MID01_RS08680	COG1338	Plays a role in the flagellum-specific transport system
MID01_RS08685	COG1987	bacterial-type flagellum assembly
MID01_RS08690	COG1684	flagellar biosynthetic protein fliR
MID01_RS08695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MID01_RS08700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MID01_RS08705	COG1419	protein localization to endoplasmic reticulum
MID01_RS08710	COG0455	bacterial-type flagellum organization
MID01_RS08715	COG2201	protein-glutamate methylesterase activity
MID01_RS08720	COG0643	Histidine kinase
MID01_RS08720	COG2198	Histidine kinase
MID01_RS08725	COG0835	chemotaxis
MID01_RS08730	COG1776	CheC inhibitor of MCP methylation
MID01_RS08735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MID01_RS08740	COG1191	sigma factor activity
MID01_RS08750	COG0052	Belongs to the universal ribosomal protein uS2 family
MID01_RS08755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MID01_RS08760	COG0528	UMP kinase activity
MID01_RS08765	COG0233	cytoplasmic translational termination
MID01_RS08770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MID01_RS08775	COG4589	Belongs to the CDS family
MID01_RS08780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MID01_RS08785	COG0750	zinc metalloprotease
MID01_RS08790	COG0442	prolyl-tRNA aminoacylation
MID01_RS08795	COG2176	DNA-directed DNA polymerase activity
MID01_RS08820	COG0779	Required for maturation of 30S ribosomal subunits
MID01_RS08825	COG0195	Participates in both transcription termination and antitermination
MID01_RS08830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MID01_RS08835	COG1358	cellular component organization or biogenesis
MID01_RS08840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MID01_RS08845	COG1550	Protein conserved in bacteria
MID01_RS08850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MID01_RS08855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MID01_RS08860	COG0196	riboflavin kinase activity
MID01_RS08865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MID01_RS08870	COG1185	polyribonucleotide nucleotidyltransferase activity
MID01_RS08875	COG0726	polysaccharide deacetylase
MID01_RS08880	COG0612	Peptidase, M16
MID01_RS08885	COG1873	PFAM PRC-barrel domain
MID01_RS08890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MID01_RS08895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MID01_RS08900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MID01_RS08905	COG0527	aspartate kinase activity
MID01_RS08910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MID01_RS08915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MID01_RS08920	COG0740	serine-type endopeptidase activity
MID01_RS08930	COG1674	ftsk spoiiie
MID01_RS08930	COG4980	gas vesicle protein
MID01_RS08935	COG2188	Transcriptional regulator
MID01_RS08940	COG2814	Major facilitator Superfamily
MID01_RS08945	COG0612	Peptidase, M16
MID01_RS08950	COG0612	Peptidase, M16
MID01_RS08955	COG0300	oxidoreductase activity
MID01_RS08970	COG1426	Protein conserved in bacteria
MID01_RS08975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MID01_RS08980	COG1546	Belongs to the CinA family
MID01_RS08980	COG1058	Belongs to the CinA family
MID01_RS08985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MID01_RS08990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MID01_RS08995	COG1418	mRNA catabolic process
MID01_RS09000	COG1692	metallophosphoesterase
MID01_RS09005	COG2359	stage V sporulation protein S
MID01_RS09010	COG1063	alcohol dehydrogenase
MID01_RS09015	COG0156	8-amino-7-oxononanoate synthase activity
MID01_RS09020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MID01_RS09025	COG4550	Control of competence regulator ComK, YlbF/YmcA
MID01_RS09035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MID01_RS09040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MID01_RS09055	COG3226	Transcriptional regulator
MID01_RS09060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS09070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MID01_RS09075	COG3321	synthase
MID01_RS09080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MID01_RS09080	COG2070	2-Nitropropane dioxygenase
MID01_RS09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID01_RS09090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MID01_RS09095	COG3425	synthase
MID01_RS09100	COG1024	Enoyl-CoA hydratase
MID01_RS09105	COG1024	Enoyl-CoA hydratase
MID01_RS09110	COG3321	synthase
MID01_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS09110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09110	COG0300	oxidoreductase activity
MID01_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS09115	COG0300	oxidoreductase activity
MID01_RS09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID01_RS09115	COG4221	oxidoreductase activity
MID01_RS09115	COG3321	synthase
MID01_RS09120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID01_RS09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID01_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS09120	COG3321	synthase
MID01_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS09125	COG3321	synthase
MID01_RS09125	COG4221	oxidoreductase activity
MID01_RS09130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID01_RS09130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MID01_RS09130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MID01_RS09130	COG3321	synthase
MID01_RS09135	COG2124	cytochrome p450
MID01_RS09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS09150	COG1404	Belongs to the peptidase S8 family
MID01_RS09160	COG4195	phage-related replication protein
MID01_RS09165	COG1764	response to oxidative stress
MID01_RS09170	COG2076	Multidrug Resistance protein
MID01_RS09175	COG2076	Multidrug Resistance protein
MID01_RS09190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MID01_RS09195	COG1923	regulation of RNA biosynthetic process
MID01_RS09210	COG1780	Probably involved in ribonucleotide reductase function
MID01_RS09215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MID01_RS09220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MID01_RS09225	COG4112	unkown
MID01_RS09230	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS09235	COG0464	growth
MID01_RS09240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MID01_RS09245	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MID01_RS09250	COG0789	Transcriptional regulator
MID01_RS09255	COG0174	glutamine synthetase
MID01_RS09280	COG4282	regulation of fungal-type cell wall biogenesis
MID01_RS09290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS09320	COG0135	phosphoribosylanthranilate isomerase activity
MID01_RS09325	COG2211	Major facilitator Superfamily
MID01_RS09330	COG3507	Belongs to the glycosyl hydrolase 43 family
MID01_RS09335	COG1940	carbohydrate kinase activity
MID01_RS09340	COG2115	Belongs to the xylose isomerase family
MID01_RS09345	COG1070	Carbohydrate kinase
MID01_RS09360	COG2814	Major facilitator Superfamily
MID01_RS09365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MID01_RS09380	COG0756	dUTP diphosphatase activity
MID01_RS09420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MID01_RS09435	COG3832	glyoxalase III activity
MID01_RS09445	COG0697	spore germination
MID01_RS09450	COG0531	amino acid
MID01_RS09480	COG4195	phage-related replication protein
MID01_RS09490	COG0346	lactoylglutathione lyase activity
MID01_RS09500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MID01_RS09505	COG1388	LysM domain
MID01_RS09510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MID01_RS09515	COG4224	UPF0291 protein
MID01_RS09520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MID01_RS09530	COG3763	UPF0154 protein
MID01_RS09540	COG0785	Cytochrome C biogenesis protein
MID01_RS09545	COG2201	protein-glutamate methylesterase activity
MID01_RS09550	COG4846	Membrane protein involved in cytochrome C biogenesis
MID01_RS09560	COG0071	Belongs to the small heat shock protein (HSP20) family
MID01_RS09575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MID01_RS09580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS09600	COG0824	Thioesterase
MID01_RS09610	COG4841	protein insertion into membrane
MID01_RS09615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MID01_RS09620	COG1832	CoA-binding protein
MID01_RS09625	COG0187	DNA topoisomerase II activity
MID01_RS09630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MID01_RS09640	COG1115	amino acid carrier protein
MID01_RS09645	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MID01_RS09655	COG5520	Belongs to the glycosyl hydrolase 30 family
MID01_RS09660	COG3507	Belongs to the glycosyl hydrolase 43 family
MID01_RS09665	COG2246	polysaccharide biosynthetic process
MID01_RS09670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MID01_RS09675	COG0586	Pfam SNARE associated Golgi protein
MID01_RS09680	COG2404	hydrolase activity, acting on ester bonds
MID01_RS09685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MID01_RS09690	COG1024	Enoyl-CoA hydratase
MID01_RS09695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MID01_RS09700	COG0511	ligase activity, forming carbon-carbon bonds
MID01_RS09705	COG0439	Biotin carboxylase
MID01_RS09710	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS09715	COG1960	acyl-CoA dehydrogenase activity
MID01_RS09725	COG1649	PFAM Uncharacterised BCR, COG1649
MID01_RS09735	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MID01_RS09735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS09760	COG2027	D-alanyl-D-alanine carboxypeptidase
MID01_RS09765	COG2017	converts alpha-aldose to the beta-anomer
MID01_RS09770	COG0534	Mate efflux family protein
MID01_RS09785	COG0582	viral genome integration into host DNA
MID01_RS09790	COG0166	Belongs to the GPI family
MID01_RS09795	COG0405	Gamma-glutamyltransferase
MID01_RS09800	COG0583	DNA-binding transcription factor activity
MID01_RS09810	COG0493	'glutamate synthase
MID01_RS09815	COG0067	glutamate synthase
MID01_RS09815	COG0069	glutamate synthase activity
MID01_RS09815	COG0070	glutamate synthase
MID01_RS09820	COG0583	DNA-binding transcription factor activity
MID01_RS09825	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MID01_RS09830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MID01_RS09840	COG0300	oxidoreductase activity
MID01_RS09845	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MID01_RS09855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MID01_RS09870	COG1131	(ABC) transporter
MID01_RS09880	COG2814	Major facilitator Superfamily
MID01_RS09885	COG1070	Carbohydrate kinase
MID01_RS09890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MID01_RS09895	COG0243	molybdopterin cofactor binding
MID01_RS09905	COG2814	Major facilitator Superfamily
MID01_RS09910	COG0673	inositol 2-dehydrogenase activity
MID01_RS09915	COG1082	Xylose isomerase domain protein TIM barrel
MID01_RS09920	COG1609	Transcriptional regulator
MID01_RS09935	COG5278	phosphoserine phosphatase activity
MID01_RS09935	COG0840	transmembrane signaling receptor activity
MID01_RS09940	COG2368	4-hydroxyphenylacetate
MID01_RS09945	COG4305	rare lipoprotein A
MID01_RS09950	COG3619	membrane
MID01_RS09955	COG3866	Pectate lyase
MID01_RS09960	COG2135	peptidase activity
MID01_RS09970	COG2140	Oxalate decarboxylase
MID01_RS09995	COG2720	vancomycin resistance protein
MID01_RS10010	COG3739	integral membrane protein
MID01_RS10015	COG0583	DNA-binding transcription factor activity
MID01_RS10020	COG0697	spore germination
MID01_RS10030	COG0693	protein deglycase activity
MID01_RS10035	COG2367	Beta-lactamase
MID01_RS10055	COG3848	Pyruvate phosphate dikinase
MID01_RS10055	COG0574	Belongs to the PEP-utilizing enzyme family
MID01_RS10060	COG0726	polysaccharide deacetylase
MID01_RS10065	COG2314	TM2 domain
MID01_RS10120	COG0457	Tetratricopeptide repeat
MID01_RS10145	COG4282	regulation of fungal-type cell wall biogenesis
MID01_RS10150	COG1231	oxidoreductase activity
MID01_RS10155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID01_RS10160	COG0662	Cupin 2, conserved barrel domain protein
MID01_RS10160	COG2207	Transcriptional regulator
MID01_RS10165	COG0456	acetyltransferase
MID01_RS10170	COG1309	transcriptional regulator
MID01_RS10175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS10180	COG3708	Transcriptional regulator
MID01_RS10185	COG2378	regulation of single-species biofilm formation
MID01_RS10195	COG0640	Transcriptional regulator
MID01_RS10200	COG0741	lytic transglycosylase activity
MID01_RS10205	COG2322	membrane
MID01_RS10220	COG1619	proteins homologs of microcin C7 resistance protein MccF
MID01_RS10225	COG3239	Fatty acid desaturase
MID01_RS10230	COG4585	Histidine kinase
MID01_RS10235	COG2197	response regulator
MID01_RS10240	COG1388	LysM domain
MID01_RS10240	COG3584	3D domain protein
MID01_RS10245	COG0514	ATP-dependent DNA helicase (RecQ)
MID01_RS10255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MID01_RS10260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MID01_RS10275	COG0071	Belongs to the small heat shock protein (HSP20) family
MID01_RS10300	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS10305	COG1657	PFAM Prenyltransferase squalene oxidase
MID01_RS10310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MID01_RS10315	COG0733	neurotransmitter:sodium symporter activity
MID01_RS10320	COG0385	Bile acid
MID01_RS10325	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID01_RS10330	COG0567	Dehydrogenase, E1 component
MID01_RS10335	COG4548	von Willebrand factor, type A
MID01_RS10340	COG0714	Associated with various cellular activities
MID01_RS10345	COG2032	superoxide dismutase activity
MID01_RS10350	COG1388	LysM domain
MID01_RS10350	COG0791	NLP P60 protein
MID01_RS10355	COG1819	glycosyl
MID01_RS10360	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MID01_RS10365	COG0534	Mate efflux family protein
MID01_RS10370	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS10375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MID01_RS10380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MID01_RS10390	COG2962	Rard protein
MID01_RS10405	COG2610	gluconate transmembrane transporter activity
MID01_RS10410	COG1942	4-Oxalocrotonate Tautomerase
MID01_RS10415	COG1733	regulation of RNA biosynthetic process
MID01_RS10420	COG0778	Nitroreductase
MID01_RS10425	COG0400	carboxylic ester hydrolase activity
MID01_RS10430	COG0346	lactoylglutathione lyase activity
MID01_RS10440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID01_RS10445	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS10445	COG0793	Belongs to the peptidase S41A family
MID01_RS10450	COG2226	methyltransferase
MID01_RS10460	COG1876	peptidase activity
MID01_RS10465	COG0813	purine-nucleoside phosphorylase activity
MID01_RS10480	COG0671	phosphoesterase, PA-phosphatase related
MID01_RS10500	COG4479	Belongs to the UPF0346 family
MID01_RS10510	COG1509	lysine 2,3-aminomutase activity
MID01_RS10515	COG0456	acetyltransferase
MID01_RS10520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID01_RS10525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MID01_RS10530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MID01_RS10535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MID01_RS10550	COG0456	acetyltransferase
MID01_RS10555	COG0463	Glycosyl transferase, family 2
MID01_RS10570	COG4641	Protein conserved in bacteria
MID01_RS10575	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
MID01_RS10580	COG1086	Polysaccharide biosynthesis protein
MID01_RS10590	COG3331	DNA recombination
MID01_RS10640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MID01_RS10675	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MID01_RS10680	COG0756	dUTP diphosphatase activity
MID01_RS10685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS10715	COG1780	Probably involved in ribonucleotide reductase function
MID01_RS10800	COG0270	DNA (cytosine-5-)-methyltransferase activity
MID01_RS10815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MID01_RS10840	COG3584	3D domain protein
MID01_RS10845	COG0587	DNA-directed DNA polymerase activity
MID01_RS10850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MID01_RS10855	COG0358	DNA primase activity
MID01_RS10860	COG0305	Participates in initiation and elongation during chromosome replication
MID01_RS10870	COG2887	Belongs to the helicase family. UvrD subfamily
MID01_RS10905	COG2135	peptidase activity
MID01_RS10910	COG1793	dna ligase
MID01_RS10950	COG1388	LysM domain
MID01_RS11010	COG3655	Transcriptional regulator
MID01_RS11025	COG0582	viral genome integration into host DNA
MID01_RS11085	COG3655	Transcriptional regulator
MID01_RS11160	COG0776	regulation of translation
MID01_RS11200	COG4373	Mu-like prophage FluMu protein gp28
MID01_RS11300	COG0582	viral genome integration into host DNA
MID01_RS11320	COG0741	lytic transglycosylase activity
MID01_RS11320	COG0739	heme binding
MID01_RS11320	COG1196	nuclear chromosome segregation
MID01_RS11330	COG2433	Pfam Transposase IS66
MID01_RS11340	COG4632	Exopolysaccharide biosynthesis protein
MID01_RS11340	COG5434	Belongs to the glycosyl hydrolase 28 family
MID01_RS11345	COG5632	N-Acetylmuramoyl-L-alanine amidase
MID01_RS11360	COG0457	Tetratricopeptide repeat
MID01_RS11400	COG5444	nuclease activity
MID01_RS11405	COG4282	regulation of fungal-type cell wall biogenesis
MID01_RS11415	COG1525	nuclease
MID01_RS11430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MID01_RS11435	COG1086	Polysaccharide biosynthesis protein
MID01_RS11440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MID01_RS11445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MID01_RS11450	COG1846	Transcriptional regulator
MID01_RS11455	COG0534	Mate efflux family protein
MID01_RS11465	COG4698	Protein conserved in bacteria
MID01_RS11470	COG2755	lipolytic protein G-D-S-L family
MID01_RS11475	COG1999	signal sequence binding
MID01_RS11485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MID01_RS11490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MID01_RS11495	COG1272	protein, Hemolysin III
MID01_RS11500	COG0204	Acyl-transferase
MID01_RS11505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MID01_RS11510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MID01_RS11520	COG2136	Putative SAM-dependent methyltransferase
MID01_RS11520	COG2521	methyltransferase
MID01_RS11530	COG0129	dihydroxy-acid dehydratase activity
MID01_RS11535	COG1413	lyase activity
MID01_RS11540	COG1418	mRNA catabolic process
MID01_RS11545	COG0386	Belongs to the glutathione peroxidase family
MID01_RS11550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MID01_RS11555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MID01_RS11565	COG1278	Cold shock
MID01_RS11585	COG0328	RNA-DNA hybrid ribonuclease activity
MID01_RS11590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MID01_RS11595	COG0328	RNA-DNA hybrid ribonuclease activity
MID01_RS11605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MID01_RS11620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MID01_RS11630	COG1755	Isoprenylcysteine carboxyl methyltransferase
MID01_RS11635	COG3424	synthase
MID01_RS11640	COG2233	PERMEase
MID01_RS11645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MID01_RS11650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MID01_RS11660	COG0800	Aldolase
MID01_RS11665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID01_RS11670	COG1609	Transcriptional regulator
MID01_RS11675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MID01_RS11680	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS11685	COG1199	ATP-dependent helicase activity
MID01_RS11700	COG0116	Belongs to the methyltransferase superfamily
MID01_RS11715	COG4474	Belongs to the UPF0398 family
MID01_RS11730	COG3359	exonuclease
MID01_RS11735	COG1205	dead DEAH box helicase
MID01_RS11735	COG1111	helicase
MID01_RS11740	COG2190	(PTS) system
MID01_RS11745	COG0071	Belongs to the small heat shock protein (HSP20) family
MID01_RS11780	COG3331	DNA recombination
MID01_RS11785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID01_RS11785	COG4499	WXG100 protein secretion system (Wss), protein YukC
MID01_RS11795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MID01_RS11800	COG3935	DnaD domain protein
MID01_RS11805	COG0017	Asparaginyl-tRNA synthetase
MID01_RS11810	COG0436	Aminotransferase
MID01_RS11815	COG5353	protein conserved in bacteria
MID01_RS11825	COG1199	ATP-dependent helicase activity
MID01_RS11825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MID01_RS11830	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MID01_RS11835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MID01_RS11840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MID01_RS11845	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MID01_RS11845	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MID01_RS11850	COG0617	tRNA 3'-terminal CCA addition
MID01_RS11855	COG0438	transferase activity, transferring glycosyl groups
MID01_RS11860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MID01_RS11865	COG1803	Methylglyoxal synthase
MID01_RS11870	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MID01_RS11875	COG1694	Mazg nucleotide pyrophosphohydrolase
MID01_RS11880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS11890	COG4347	Protein of unknown function (DUF1405)
MID01_RS11895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MID01_RS11895	COG2010	Cytochrome c
MID01_RS11900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MID01_RS11905	COG0723	plastoquinol--plastocyanin reductase activity
MID01_RS11915	COG5582	Belongs to the UPF0302 family
MID01_RS11920	COG0457	Tetratricopeptide repeat
MID01_RS11925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MID01_RS11930	COG0287	Prephenate dehydrogenase
MID01_RS11935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MID01_RS11945	COG0133	tryptophan synthase activity
MID01_RS11950	COG0135	phosphoribosylanthranilate isomerase activity
MID01_RS11960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MID01_RS11965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MID01_RS11970	COG4401	Chorismate mutase type I
MID01_RS11975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MID01_RS11980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MID01_RS11985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MID01_RS11990	COG0105	UTP biosynthetic process
MID01_RS11995	COG0142	geranyltranstransferase activity
MID01_RS12000	COG2226	methyltransferase
MID01_RS12005	COG0142	geranyltranstransferase activity
MID01_RS12015	COG0302	gtp cyclohydrolase
MID01_RS12020	COG0776	regulation of translation
MID01_RS12025	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MID01_RS12040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MID01_RS12045	COG1160	GTP binding
MID01_RS12070	COG1304	FMN binding
MID01_RS12075	COG0539	negative regulation of cytoplasmic translation
MID01_RS12080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MID01_RS12090	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MID01_RS12095	COG2959	enzyme of heme biosynthesis
MID01_RS12100	COG3773	Cell wall hydrolase
MID01_RS12100	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS12105	COG2339	peptidase activity
MID01_RS12110	COG0492	ferredoxin-NADP+ reductase activity
MID01_RS12115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MID01_RS12120	COG4862	establishment of competence for transformation
MID01_RS12125	COG1408	metallophosphoesterase
MID01_RS12135	COG1388	LysM domain
MID01_RS12140	COG1266	CAAX protease self-immunity
MID01_RS12145	COG0514	ATP-dependent DNA helicase (RecQ)
MID01_RS12150	COG4955	Helix-turn-helix domain
MID01_RS12155	COG1141	Ferredoxin
MID01_RS12160	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MID01_RS12165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MID01_RS12170	COG0710	3-dehydroquinate dehydratase activity
MID01_RS12180	COG1595	DNA-templated transcription, initiation
MID01_RS12185	COG5002	protein histidine kinase activity
MID01_RS12190	COG0745	RESPONSE REGULATOR receiver
MID01_RS12195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MID01_RS12200	COG1333	cytochrome c biogenesis protein
MID01_RS12205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS12210	COG1187	pseudouridine synthase activity
MID01_RS12215	COG0700	Nucleoside recognition
MID01_RS12220	COG2715	membrane protein required for spore maturation
MID01_RS12225	COG1686	Belongs to the peptidase S11 family
MID01_RS12235	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MID01_RS12240	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MID01_RS12245	COG1547	Domain of unknown function (DUF309)
MID01_RS12250	COG0456	acetyltransferase
MID01_RS12255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MID01_RS12260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MID01_RS12260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MID01_RS12265	COG0307	riboflavin synthase, alpha
MID01_RS12270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MID01_RS12270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MID01_RS12280	COG0681	Belongs to the peptidase S26 family
MID01_RS12300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MID01_RS12305	COG4086	secreted protein
MID01_RS12310	COG0019	diaminopimelate decarboxylase activity
MID01_RS12315	COG0697	spore germination
MID01_RS12330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MID01_RS12350	COG1191	sigma factor activity
MID01_RS12355	COG2172	sigma factor antagonist activity
MID01_RS12360	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS12365	COG1686	Belongs to the peptidase S11 family
MID01_RS12370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MID01_RS12375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MID01_RS12380	COG4974	Belongs to the 'phage' integrase family
MID01_RS12390	COG0735	belongs to the Fur family
MID01_RS12395	COG1300	Membrane
MID01_RS12405	COG0281	malic enzyme
MID01_RS12410	COG1757	Na H antiporter
MID01_RS12415	COG1027	Aspartate ammonia-lyase
MID01_RS12420	COG0252	asparaginase activity
MID01_RS12425	COG1396	sequence-specific DNA binding
MID01_RS12430	COG1379	DNA repair
MID01_RS12435	COG0494	nUDIX hydrolase
MID01_RS12445	COG0667	Aldo Keto reductase
MID01_RS12455	COG1073	alpha beta
MID01_RS12465	COG4918	Iron-sulphur cluster biosynthesis
MID01_RS12470	COG0456	acetyltransferase
MID01_RS12470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MID01_RS12475	COG2329	Antibiotic biosynthesis monooxygenase
MID01_RS12480	COG0456	acetyltransferase
MID01_RS12490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MID01_RS12500	COG2211	Major facilitator Superfamily
MID01_RS12510	COG0346	lactoylglutathione lyase activity
MID01_RS12515	COG1072	(Pantothenic acid kinase))
MID01_RS12520	COG3048	D-serine ammonia-lyase activity
MID01_RS12525	COG0300	oxidoreductase activity
MID01_RS12530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS12535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MID01_RS12540	COG4187	Peptidase family M20/M25/M40
MID01_RS12545	COG1902	pentaerythritol trinitrate reductase activity
MID01_RS12550	COG0596	Alpha beta hydrolase
MID01_RS12560	COG1234	tRNA 3'-trailer cleavage
MID01_RS12565	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MID01_RS12570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MID01_RS12575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MID01_RS12585	COG0706	membrane insertase activity
MID01_RS12590	COG3361	conserved protein (COG2071)
MID01_RS12595	COG2195	Cleaves the N-terminal amino acid of tripeptides
MID01_RS12600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MID01_RS12605	COG0346	lactoylglutathione lyase activity
MID01_RS12615	COG1376	ErfK ybiS ycfS ynhG family protein
MID01_RS12620	COG4129	membrane
MID01_RS12625	COG1126	abc transporter atp-binding protein
MID01_RS12630	COG0765	amino acid transport
MID01_RS12635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS12645	COG1597	lipid kinase activity
MID01_RS12650	COG2814	Major facilitator Superfamily
MID01_RS12655	COG4978	Transcriptional regulator
MID01_RS12655	COG0789	Transcriptional regulator
MID01_RS12660	COG0508	dehydrogenase complex catalyzes the overall conversion of
MID01_RS12665	COG0022	dehydrogenase e1 component
MID01_RS12670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MID01_RS12675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MID01_RS12680	COG3426	butyrate kinase activity
MID01_RS12685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MID01_RS12690	COG0280	phosphate acetyltransferase
MID01_RS12695	COG3829	transcription factor binding
MID01_RS12695	COG3290	protein histidine kinase activity
MID01_RS12705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MID01_RS12710	COG2079	MmgE PrpD family protein
MID01_RS12715	COG0372	Belongs to the citrate synthase family
MID01_RS12720	COG1960	acyl-CoA dehydrogenase activity
MID01_RS12725	COG1250	3-hydroxyacyl-CoA dehydrogenase
MID01_RS12730	COG0183	Belongs to the thiolase family
MID01_RS12735	COG0584	glycerophosphoryl diester phosphodiesterase
MID01_RS12740	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS12755	COG1902	pentaerythritol trinitrate reductase activity
MID01_RS12760	COG0745	RESPONSE REGULATOR receiver
MID01_RS12765	COG0750	zinc metalloprotease
MID01_RS12770	COG0497	DNA recombination
MID01_RS12775	COG1438	arginine binding
MID01_RS12780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MID01_RS12785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MID01_RS12790	COG0142	geranyltranstransferase activity
MID01_RS12795	COG1722	exodeoxyribonuclease VII activity
MID01_RS12800	COG1570	exodeoxyribonuclease VII activity
MID01_RS12805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MID01_RS12810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MID01_RS12815	COG1302	Protein conserved in bacteria
MID01_RS12820	COG0439	Biotin carboxylase
MID01_RS12825	COG0511	ligase activity, forming carbon-carbon bonds
MID01_RS12865	COG3854	ATPases associated with a variety of cellular activities
MID01_RS12875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MID01_RS12880	COG0006	proline dipeptidase activity
MID01_RS12885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MID01_RS12895	COG3872	metal-dependent enzyme
MID01_RS12905	COG1752	Esterase of the alpha-beta hydrolase superfamily
MID01_RS12910	COG1321	iron dependent repressor
MID01_RS12915	COG0095	Lipoate-protein ligase
MID01_RS12920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID01_RS12925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MID01_RS12930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MID01_RS12935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MID01_RS12940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MID01_RS12955	COG1396	sequence-specific DNA binding
MID01_RS12965	COG0681	Belongs to the peptidase S26 family
MID01_RS12990	COG4940	Competence protein ComGF
MID01_RS13000	COG4970	Tfp pilus assembly protein FimT
MID01_RS13005	COG4537	Required for transformation and DNA binding
MID01_RS13010	COG1459	type II secretion system
MID01_RS13015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MID01_RS13020	COG0598	Magnesium transport protein CorA
MID01_RS13025	COG1253	flavin adenine dinucleotide binding
MID01_RS13030	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS13040	COG1393	Belongs to the ArsC family
MID01_RS13050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS13060	COG0011	TIGRFAM Protein of
MID01_RS13070	COG2866	Carboxypeptidase
MID01_RS13075	COG1368	sulfuric ester hydrolase activity
MID01_RS13080	COG1940	carbohydrate kinase activity
MID01_RS13085	COG4483	Protein conserved in bacteria
MID01_RS13090	COG0457	Tetratricopeptide repeat
MID01_RS13090	COG0705	Rhomboid family
MID01_RS13100	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MID01_RS13110	COG0438	transferase activity, transferring glycosyl groups
MID01_RS13125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MID01_RS13130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MID01_RS13135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MID01_RS13140	COG0581	inorganic phosphate transmembrane transporter activity
MID01_RS13145	COG0573	inorganic phosphate transmembrane transporter activity
MID01_RS13150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MID01_RS13155	COG0768	penicillin binding
MID01_RS13160	COG0477	Major facilitator Superfamily
MID01_RS13165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MID01_RS13170	COG2839	Protein conserved in bacteria
MID01_RS13175	COG5521	maltodextrose utilization protein MalA
MID01_RS13180	COG1388	LysM domain
MID01_RS13185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MID01_RS13190	COG4709	membrane
MID01_RS13195	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MID01_RS13200	COG0735	belongs to the Fur family
MID01_RS13205	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS13215	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MID01_RS13220	COG0513	Belongs to the DEAD box helicase family
MID01_RS13230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MID01_RS13235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MID01_RS13240	COG2384	SAM-dependent methyltransferase
MID01_RS13245	COG2010	Cytochrome c
MID01_RS13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MID01_RS13255	COG0358	DNA primase activity
MID01_RS13260	COG1671	Belongs to the UPF0178 family
MID01_RS13265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MID01_RS13270	COG0517	IMP dehydrogenase activity
MID01_RS13275	COG0751	glycine-tRNA ligase activity
MID01_RS13280	COG0752	glycyl-tRNA synthetase alpha subunit
MID01_RS13285	COG1381	Involved in DNA repair and RecF pathway recombination
MID01_RS13295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MID01_RS13300	COG0295	cytidine deaminase activity
MID01_RS13305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MID01_RS13310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MID01_RS13315	COG1480	7TM receptor with intracellular HD hydrolase
MID01_RS13320	COG1702	phosphate starvation-inducible protein PhoH
MID01_RS13325	COG0561	phosphatase activity
MID01_RS13340	COG4864	UPF0365 protein
MID01_RS13345	COG1030	water channel activity
MID01_RS13350	COG1610	YqeY-like protein
MID01_RS13360	COG1283	sodium-dependent phosphate transmembrane transporter activity
MID01_RS13365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MID01_RS13370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MID01_RS13375	COG2264	protein methyltransferase activity
MID01_RS13380	COG0484	heat shock protein binding
MID01_RS13385	COG0443	Heat shock 70 kDa protein
MID01_RS13390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MID01_RS13395	COG1420	regulation of RNA biosynthetic process
MID01_RS13400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MID01_RS13405	COG0481	GTPase activity
MID01_RS13415	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS13420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MID01_RS13425	COG0268	Binds directly to 16S ribosomal RNA
MID01_RS13430	COG1466	dna polymerase III delta subunit
MID01_RS13445	COG0658	competence protein
MID01_RS13445	COG2333	competence protein COMEC
MID01_RS13450	COG2131	deaminase
MID01_RS13455	COG1555	photosystem II stabilization
MID01_RS13455	COG1596	polysaccharide export
MID01_RS13460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MID01_RS13465	COG2226	methyltransferase
MID01_RS13470	COG0799	negative regulation of ribosome biogenesis
MID01_RS13475	COG1713	HD superfamily hydrolase involved in NAD metabolism
MID01_RS13480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MID01_RS13485	COG1534	Rna-binding protein
MID01_RS13490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MID01_RS13495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MID01_RS13500	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MID01_RS13510	COG2755	lipolytic protein G-D-S-L family
MID01_RS13515	COG5632	N-Acetylmuramoyl-L-alanine amidase
MID01_RS13515	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS13520	COG0398	Pfam SNARE associated Golgi protein
MID01_RS13525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MID01_RS13535	COG3209	COG3209 Rhs family protein
MID01_RS13545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MID01_RS13555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MID01_RS13560	COG0798	PFAM Bile acid sodium symporter
MID01_RS13565	COG0346	lactoylglutathione lyase activity
MID01_RS13570	COG0640	Transcriptional regulator
MID01_RS13575	COG3403	YqcI/YcgG family
MID01_RS13580	COG0457	Tetratricopeptide repeat
MID01_RS13595	COG5444	nuclease activity
MID01_RS13620	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS13620	COG5632	N-Acetylmuramoyl-L-alanine amidase
MID01_RS13625	COG4824	toxin secretion phage lysis holin
MID01_RS13655	COG3778	Protein conserved in bacteria
MID01_RS13660	COG3299	homolog of phage Mu protein gp47
MID01_RS13665	COG3628	GPW Gp25 family protein
MID01_RS13675	COG4193	domain, Protein
MID01_RS13680	COG1652	LysM domain
MID01_RS13685	COG5280	Phage tail tape measure protein TP901
MID01_RS13685	COG3953	SLT domain
MID01_RS13750	COG4653	Phage capsid family
MID01_RS13755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MID01_RS13765	COG2369	cell adhesion
MID01_RS13770	COG5518	Phage portal protein
MID01_RS13775	COG1783	phage Terminase large subunit
MID01_RS13780	COG5484	DNA packaging
MID01_RS13790	COG3677	Transposase
MID01_RS13805	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
MID01_RS13815	COG1484	DNA-dependent DNA replication
MID01_RS13820	COG3935	DnaD domain protein
MID01_RS13825	COG3723	Recombinational DNA repair protein, rece pathway
MID01_RS13830	COG5377	YqaJ viral recombinase family
MID01_RS13860	COG1476	TRANSCRIPTIONal
MID01_RS13865	COG3620	sequence-specific DNA binding
MID01_RS13875	COG0563	adenylate kinase activity
MID01_RS13880	COG2856	Zn peptidase
MID01_RS13905	COG3223	Belongs to the PsiE family
MID01_RS13910	COG5002	protein histidine kinase activity
MID01_RS13910	COG0642	Histidine kinase
MID01_RS13915	COG0745	RESPONSE REGULATOR receiver
MID01_RS13920	COG2311	Membrane
MID01_RS13930	COG0454	-acetyltransferase
MID01_RS13935	COG2249	NAD(P)H dehydrogenase (quinone) activity
MID01_RS13945	COG0730	response to heat
MID01_RS13950	COG0425	Belongs to the sulfur carrier protein TusA family
MID01_RS13965	COG0425	Belongs to the sulfur carrier protein TusA family
MID01_RS13965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID01_RS13975	COG2210	Belongs to the sulfur carrier protein TusA family
MID01_RS13980	COG1937	Protein conserved in bacteria
MID01_RS13990	COG0662	Cupin 2, conserved barrel domain protein
MID01_RS14005	COG0789	Transcriptional regulator
MID01_RS14005	COG4978	Transcriptional regulator
MID01_RS14010	COG2814	Major facilitator Superfamily
MID01_RS14015	COG0456	acetyltransferase
MID01_RS14020	COG1253	flavin adenine dinucleotide binding
MID01_RS14030	COG0697	spore germination
MID01_RS14035	COG0583	DNA-binding transcription factor activity
MID01_RS14040	COG2072	flavoprotein involved in K transport
MID01_RS14045	COG1230	cation diffusion facilitator family transporter
MID01_RS14050	COG1942	4-Oxalocrotonate Tautomerase
MID01_RS14055	COG0583	DNA-binding transcription factor activity
MID01_RS14065	COG1114	Component of the transport system for branched-chain amino acids
MID01_RS14070	COG1687	branched-chain amino acid
MID01_RS14075	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MID01_RS14080	COG1522	sequence-specific DNA binding
MID01_RS14085	COG2732	(Barnase) inhibitor
MID01_RS14090	COG2124	cytochrome p450
MID01_RS14100	COG1335	isochorismatase
MID01_RS14115	COG2318	DinB family
MID01_RS14125	COG2070	2-Nitropropane dioxygenase
MID01_RS14130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MID01_RS14140	COG2186	Transcriptional regulator
MID01_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS14160	COG3958	Transketolase
MID01_RS14165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MID01_RS14170	COG0477	Major facilitator Superfamily
MID01_RS14175	COG1846	Transcriptional regulator
MID01_RS14180	COG3443	Belongs to the bacterial solute-binding protein 9 family
MID01_RS14185	COG1595	DNA-templated transcription, initiation
MID01_RS14190	COG0667	Aldo Keto reductase
MID01_RS14195	COG2851	Citrate transporter
MID01_RS14200	COG0583	DNA-binding transcription factor activity
MID01_RS14205	COG2828	Protein conserved in bacteria
MID01_RS14210	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS14215	COG5566	PFAM Mor transcription activator
MID01_RS14220	COG0596	Alpha beta hydrolase
MID01_RS14225	COG4991	sh3 domain protein
MID01_RS14230	COG4991	sh3 domain protein
MID01_RS14240	COG0346	lactoylglutathione lyase activity
MID01_RS14250	COG5577	PFAM Coat F domain
MID01_RS14255	COG1063	alcohol dehydrogenase
MID01_RS14265	COG5577	PFAM Coat F domain
MID01_RS14270	COG0789	Transcriptional regulator
MID01_RS14280	COG1064	alcohol dehydrogenase
MID01_RS14285	COG0693	protein deglycase activity
MID01_RS14290	COG1621	beta-fructofuranosidase activity
MID01_RS14300	COG3716	PTS system mannose fructose sorbose family IID component
MID01_RS14305	COG3715	PTS system
MID01_RS14310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS14315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS14320	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MID01_RS14320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MID01_RS14330	COG1113	amino acid transport
MID01_RS14335	COG1280	lysine exporter protein (LysE YggA)
MID01_RS14340	COG1378	Sugar-specific transcriptional regulator TrmB
MID01_RS14345	COG1595	DNA-templated transcription, initiation
MID01_RS14355	COG2755	lipolytic protein G-D-S-L family
MID01_RS14355	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MID01_RS14365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MID01_RS14365	COG2124	cytochrome p450
MID01_RS14370	COG1309	transcriptional regulator
MID01_RS14375	COG2226	methyltransferase
MID01_RS14390	COG2116	formate transmembrane transporter activity
MID01_RS14395	COG5609	conserved protein (DUF2294)
MID01_RS14400	COG3383	formate dehydrogenase (NAD+) activity
MID01_RS14405	COG2427	Protein of unknown function (DUF1641)
MID01_RS14415	COG0626	cystathionine gamma-synthase activity
MID01_RS14420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MID01_RS14425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MID01_RS14430	COG2226	methyltransferase
MID01_RS14445	COG0768	penicillin binding
MID01_RS14450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MID01_RS14455	COG0572	uridine kinase
MID01_RS14460	COG0826	peptidase U32
MID01_RS14465	COG0826	peptidase U32
MID01_RS14470	COG4122	O-methyltransferase activity
MID01_RS14475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MID01_RS14480	COG3906	Belongs to the UPF0473 family
MID01_RS14485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MID01_RS14490	COG4472	Bacterial protein of unknown function (DUF965)
MID01_RS14495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MID01_RS14500	COG0628	permease
MID01_RS14505	COG1126	abc transporter atp-binding protein
MID01_RS14510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS14515	COG0765	amino acid transport
MID01_RS14520	COG0765	amino acid transport
MID01_RS14535	COG3881	PFAM PRC-barrel domain
MID01_RS14540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MID01_RS14545	COG0457	Tetratricopeptide repeat
MID01_RS14550	COG0482	sulfurtransferase activity
MID01_RS14555	COG1104	cysteine desulfurase activity
MID01_RS14560	COG1959	2 iron, 2 sulfur cluster binding
MID01_RS14565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MID01_RS14570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MID01_RS14580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MID01_RS14585	COG0124	histidyl-tRNA synthetase
MID01_RS14595	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS14595	COG4991	sh3 domain protein
MID01_RS14595	COG3103	Sh3 type 3 domain protein
MID01_RS14600	COG1490	D-aminoacyl-tRNA deacylase activity
MID01_RS14605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MID01_RS14610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MID01_RS14615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MID01_RS14615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MID01_RS14620	COG5416	Lipopolysaccharide assembly protein A domain
MID01_RS14625	COG0490	domain, Protein
MID01_RS14630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MID01_RS14630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MID01_RS14640	COG2244	polysaccharide biosynthetic process
MID01_RS14645	COG2323	membrane
MID01_RS14655	COG1862	Preprotein translocase
MID01_RS14660	COG0343	queuine tRNA-ribosyltransferase activity
MID01_RS14665	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MID01_RS14675	COG2255	four-way junction helicase activity
MID01_RS14680	COG0632	four-way junction helicase activity
MID01_RS14690	COG2814	Major facilitator Superfamily
MID01_RS14695	COG0673	inositol 2-dehydrogenase activity
MID01_RS14700	COG2112	serine threonine protein kinase
MID01_RS14720	COG1115	amino acid carrier protein
MID01_RS14725	COG0217	transcriptional regulatory protein
MID01_RS14735	COG1388	LysM domain
MID01_RS14740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MID01_RS14745	COG0157	Belongs to the NadC ModD family
MID01_RS14750	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MID01_RS14755	COG1104	cysteine desulfurase activity
MID01_RS14760	COG1827	regulation of RNA biosynthetic process
MID01_RS14765	COG0077	Prephenate dehydratase
MID01_RS14770	COG4492	Belongs to the UPF0735 family
MID01_RS14775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MID01_RS14780	COG3290	protein histidine kinase activity
MID01_RS14790	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MID01_RS14795	COG2868	ribosomal protein
MID01_RS14800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MID01_RS14805	COG1994	Peptidase M50
MID01_RS14810	COG0739	heme binding
MID01_RS14815	COG2894	cell division
MID01_RS14820	COG0850	regulation of cytokinetic process
MID01_RS14825	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MID01_RS14835	COG1077	Cell shape determining protein MreB Mrl
MID01_RS14840	COG2003	Belongs to the UPF0758 family
MID01_RS14845	COG0424	maF-like protein
MID01_RS14855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MID01_RS14860	COG0285	dihydrofolate synthase activity
MID01_RS14865	COG0525	valine-tRNA ligase activity
MID01_RS14875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID01_RS14880	COG1388	LysM domain
MID01_RS14885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MID01_RS14890	COG0113	porphobilinogen synthase activity
MID01_RS14895	COG1587	Uroporphyrinogen-III synthase
MID01_RS14900	COG0181	hydroxymethylbilane synthase activity
MID01_RS14905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MID01_RS14910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MID01_RS14920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MID01_RS14925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MID01_RS14930	COG1067	ATP-dependent peptidase activity
MID01_RS14930	COG0470	DNA polymerase III
MID01_RS14935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MID01_RS14940	COG0544	peptidyl-prolyl cis-trans isomerase activity
MID01_RS14945	COG0457	Tetratricopeptide repeat
MID01_RS14945	COG1477	protein flavinylation
MID01_RS14950	COG0066	3-isopropylmalate dehydratase activity
MID01_RS14955	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MID01_RS14960	COG0473	3-isopropylmalate dehydrogenase activity
MID01_RS14965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MID01_RS14970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MID01_RS14975	COG0440	acetolactate synthase activity
MID01_RS14980	COG0028	Belongs to the TPP enzyme family
MID01_RS14990	COG0454	-acetyltransferase
MID01_RS14995	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MID01_RS15020	COG1674	ftsk spoiiie
MID01_RS15080	COG5280	Phage tail tape measure protein TP901
MID01_RS15080	COG3953	SLT domain
MID01_RS15130	COG0740	serine-type endopeptidase activity
MID01_RS15185	COG1216	Glycosyl transferase, family 2
MID01_RS15195	COG4195	phage-related replication protein
MID01_RS15200	COG5434	Belongs to the glycosyl hydrolase 28 family
MID01_RS15200	COG3420	alginic acid biosynthetic process
MID01_RS15225	COG1793	dna ligase
MID01_RS15270	COG1388	LysM domain
MID01_RS15270	COG3584	3D domain protein
MID01_RS15275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MID01_RS15285	COG0756	dUTP diphosphatase activity
MID01_RS15290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MID01_RS15315	COG1780	Probably involved in ribonucleotide reductase function
MID01_RS15335	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MID01_RS15480	COG0622	Phosphoesterase
MID01_RS15485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MID01_RS15490	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MID01_RS15495	COG5401	PFAM Sporulation and spore germination
MID01_RS15500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MID01_RS15505	COG1846	Transcriptional regulator
MID01_RS15510	COG2197	response regulator
MID01_RS15515	COG0824	Thioesterase
MID01_RS15520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MID01_RS15525	COG1053	succinate dehydrogenase
MID01_RS15530	COG2009	succinate dehydrogenase
MID01_RS15535	COG1719	4-vinyl reductase, 4VR
MID01_RS15540	COG0527	aspartate kinase activity
MID01_RS15545	COG0322	excinuclease ABC activity
MID01_RS15550	COG3118	belongs to the thioredoxin family
MID01_RS15555	COG3534	alpha-L-arabinofuranosidase
MID01_RS15560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MID01_RS15565	COG2086	electron transfer activity
MID01_RS15570	COG1024	Enoyl-CoA hydratase
MID01_RS15575	COG1309	transcriptional regulator
MID01_RS15580	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS15585	COG3766	membrane
MID01_RS15590	COG1193	negative regulation of DNA recombination
MID01_RS15595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MID01_RS15595	COG1796	DNA polymerase
MID01_RS15600	COG1286	toxin biosynthetic process
MID01_RS15605	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MID01_RS15610	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MID01_RS15615	COG0072	phenylalanine-tRNA ligase activity
MID01_RS15615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID01_RS15620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MID01_RS15630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MID01_RS15640	COG3835	regulator
MID01_RS15645	COG0277	FAD linked oxidase domain protein
MID01_RS15650	COG0247	lactate metabolic process
MID01_RS15655	COG0346	lactoylglutathione lyase activity
MID01_RS15665	COG1966	Carbon starvation protein
MID01_RS15670	COG3534	alpha-L-arabinofuranosidase
MID01_RS15675	COG0395	ABC-type sugar transport system, permease component
MID01_RS15680	COG1175	transmembrane transport
MID01_RS15685	COG1653	transport
MID01_RS15690	COG0371	Dehydrogenase
MID01_RS15695	COG0647	UMP catabolic process
MID01_RS15700	COG0235	Class ii aldolase
MID01_RS15705	COG1069	ribulokinase activity
MID01_RS15710	COG2160	L-arabinose isomerase activity
MID01_RS15715	COG3507	Belongs to the glycosyl hydrolase 43 family
MID01_RS15720	COG1363	Peptidase, m42
MID01_RS15730	COG3326	Membrane
MID01_RS15735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MID01_RS15740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MID01_RS15745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MID01_RS15755	COG1346	cytolysis
MID01_RS15760	COG1380	Effector of murein hydrolase LrgA
MID01_RS15765	COG3279	Response regulator of the LytR AlgR family
MID01_RS15770	COG3275	phosphorelay sensor kinase activity
MID01_RS15775	COG1011	Hydrolase
MID01_RS15780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MID01_RS15790	COG0398	Pfam SNARE associated Golgi protein
MID01_RS15795	COG1484	DNA-dependent DNA replication
MID01_RS15800	COG3611	Membrane attachment protein
MID01_RS15805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MID01_RS15810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MID01_RS15815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MID01_RS15820	COG1733	regulation of RNA biosynthetic process
MID01_RS15825	COG2814	Major facilitator Superfamily
MID01_RS15830	COG0656	L-ascorbic acid biosynthetic process
MID01_RS15835	COG0237	dephospho-CoA kinase activity
MID01_RS15840	COG1971	Probably functions as a manganese efflux pump
MID01_RS15845	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MID01_RS15850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MID01_RS15850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MID01_RS15855	COG5002	protein histidine kinase activity
MID01_RS15860	COG0745	RESPONSE REGULATOR receiver
MID01_RS15865	COG0039	L-malate dehydrogenase activity
MID01_RS15870	COG0538	isocitrate dehydrogenase activity
MID01_RS15875	COG0372	Belongs to the citrate synthase family
MID01_RS15880	COG2707	UPF0756 membrane protein
MID01_RS15885	COG0628	permease
MID01_RS15890	COG3030	protein affecting phage T7 exclusion by the F plasmid
MID01_RS15895	COG0469	pyruvate kinase activity
MID01_RS15900	COG0205	6-phosphofructokinase activity
MID01_RS15905	COG0825	malonyl-CoA metabolic process
MID01_RS15910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MID01_RS15915	COG0281	malic enzyme
MID01_RS15920	COG0587	DNA-directed DNA polymerase activity
MID01_RS15940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MID01_RS15950	COG4109	DRTGG domain
MID01_RS15955	COG0730	response to heat
MID01_RS15960	COG1473	amidohydrolase
MID01_RS15965	COG0196	riboflavin kinase activity
MID01_RS15970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS15975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MID01_RS15980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS15985	COG1126	abc transporter atp-binding protein
MID01_RS15990	COG0765	amino acid transport
MID01_RS15995	COG0765	amino acid transport
MID01_RS16000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS16010	COG0454	-acetyltransferase
MID01_RS16015	COG0583	DNA-binding transcription factor activity
MID01_RS16020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MID01_RS16025	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS16030	COG0165	Argininosuccinate lyase
MID01_RS16035	COG0137	argininosuccinate synthase activity
MID01_RS16040	COG0521	Mo-molybdopterin cofactor biosynthetic process
MID01_RS16045	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MID01_RS16055	COG0827	DNA restriction-modification system
MID01_RS16060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MID01_RS16065	COG3874	Sporulation protein YtfJ
MID01_RS16075	COG1714	RDD family
MID01_RS16080	COG0616	signal peptide processing
MID01_RS16085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MID01_RS16090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MID01_RS16095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MID01_RS16105	COG0301	tRNA thio-modification
MID01_RS16110	COG1104	cysteine desulfurase activity
MID01_RS16115	COG1114	Component of the transport system for branched-chain amino acids
MID01_RS16120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MID01_RS16125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MID01_RS16130	COG1309	transcriptional regulator
MID01_RS16135	COG1956	GAF domain-containing protein
MID01_RS16140	COG2199	diguanylate cyclase activity
MID01_RS16140	COG2203	Gaf domain
MID01_RS16145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MID01_RS16150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MID01_RS16155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MID01_RS16160	COG0454	-acetyltransferase
MID01_RS16165	COG0517	IMP dehydrogenase activity
MID01_RS16170	COG0123	including yeast histone deacetylase and acetoin utilization protein
MID01_RS16175	COG1360	Flagellar Motor Protein
MID01_RS16180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MID01_RS16185	COG1609	Transcriptional regulator
MID01_RS16190	COG1605	Chorismate mutase
MID01_RS16190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MID01_RS16195	COG3118	belongs to the thioredoxin family
MID01_RS16200	COG4980	gas vesicle protein
MID01_RS16205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MID01_RS16210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MID01_RS16215	COG1674	ftsk spoiiie
MID01_RS16220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MID01_RS16225	COG4848	Belongs to the UPF0354 family
MID01_RS16230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS16245	COG1363	Peptidase, m42
MID01_RS16250	COG5584	Small secreted protein
MID01_RS16255	COG0281	malic enzyme
MID01_RS16260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS16265	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MID01_RS16275	COG0510	thiamine kinase activity
MID01_RS16280	COG1523	belongs to the glycosyl hydrolase 13 family
MID01_RS16285	COG1597	lipid kinase activity
MID01_RS16295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MID01_RS16300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MID01_RS16305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID01_RS16310	COG2252	PERMEase
MID01_RS16315	COG4473	ABC transporter
MID01_RS16320	COG1131	(ABC) transporter
MID01_RS16325	COG1349	DNA-binding transcription factor activity
MID01_RS16330	COG1187	pseudouridine synthase activity
MID01_RS16335	COG2244	polysaccharide biosynthetic process
MID01_RS16340	COG2081	HI0933 family
MID01_RS16345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MID01_RS16355	COG5578	integral membrane protein
MID01_RS16360	COG0673	inositol 2-dehydrogenase activity
MID01_RS16365	COG1653	transport
MID01_RS16370	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MID01_RS16375	COG4209	transmembrane transport
MID01_RS16380	COG2207	Transcriptional regulator
MID01_RS16385	COG1653	transport
MID01_RS16390	COG0395	ABC-type sugar transport system, permease component
MID01_RS16395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID01_RS16400	COG2124	cytochrome p450
MID01_RS16405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MID01_RS16415	COG0156	8-amino-7-oxononanoate synthase activity
MID01_RS16420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MID01_RS16430	COG1073	alpha beta
MID01_RS16435	COG1609	Transcriptional regulator
MID01_RS16440	COG1653	transport
MID01_RS16445	COG1175	transmembrane transport
MID01_RS16450	COG0395	ABC-type sugar transport system, permease component
MID01_RS16455	COG1486	melibiose metabolic process
MID01_RS16460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MID01_RS16465	COG0495	leucyl-tRNA aminoacylation
MID01_RS16475	COG2202	Pas domain
MID01_RS16475	COG1366	Belongs to the anti-sigma-factor antagonist family
MID01_RS16480	COG2814	Major facilitator Superfamily
MID01_RS16485	COG2433	Pfam Transposase IS66
MID01_RS16490	COG0577	efflux transmembrane transporter activity
MID01_RS16495	COG1136	(ABC) transporter
MID01_RS16500	COG2205	protein histidine kinase activity
MID01_RS16505	COG0745	RESPONSE REGULATOR receiver
MID01_RS16510	COG0577	efflux transmembrane transporter activity
MID01_RS16515	COG1136	(ABC) transporter
MID01_RS16530	COG1131	(ABC) transporter
MID01_RS16535	COG1725	Transcriptional regulator
MID01_RS16550	COG1242	4 iron, 4 sulfur cluster binding
MID01_RS16555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MID01_RS16565	COG2267	carboxylic ester hydrolase activity
MID01_RS16570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MID01_RS16575	COG1113	amino acid transport
MID01_RS16580	COG0367	asparagine synthase
MID01_RS16585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MID01_RS16590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MID01_RS16600	COG1506	peptidase
MID01_RS16605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MID01_RS16610	COG1116	anion transmembrane transporter activity
MID01_RS16615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MID01_RS16620	COG0494	nUDIX hydrolase
MID01_RS16625	COG4824	toxin secretion phage lysis holin
MID01_RS16630	COG0783	Belongs to the Dps family
MID01_RS16645	COG1854	S-ribosylhomocysteine lyase activity
MID01_RS16650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MID01_RS16655	COG0288	reversible hydration of carbon dioxide
MID01_RS16660	COG0254	rRNA binding
MID01_RS16665	COG1271	oxidase subunit
MID01_RS16670	COG1294	oxidase, subunit
MID01_RS16680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MID01_RS16685	COG1321	iron dependent repressor
MID01_RS16685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MID01_RS16690	COG1121	(ABC) transporter
MID01_RS16695	COG0803	Belongs to the bacterial solute-binding protein 9 family
MID01_RS16700	COG4948	Mandelate Racemase Muconate Lactonizing
MID01_RS16705	COG0318	PFAM AMP-dependent synthetase and ligase
MID01_RS16710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MID01_RS16715	COG0596	Alpha beta hydrolase
MID01_RS16720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MID01_RS16725	COG1169	isochorismate synthase
MID01_RS16730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MID01_RS16735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MID01_RS16740	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MID01_RS16745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MID01_RS16750	COG0438	transferase activity, transferring glycosyl groups
MID01_RS16760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID01_RS16765	COG0438	transferase activity, transferring glycosyl groups
MID01_RS16770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID01_RS16775	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MID01_RS16780	COG0058	SHG alpha-glucan phosphorylase activity
MID01_RS16785	COG0297	glycogen (starch) synthase activity
MID01_RS16790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MID01_RS16795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MID01_RS16800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MID01_RS16925	COG3859	Proton-coupled thiamine transporter YuaJ
MID01_RS16930	COG1247	-acetyltransferase
MID01_RS16935	COG2268	Band 7 protein
MID01_RS16940	COG1585	Membrane protein implicated in regulation of membrane protease activity
MID01_RS16945	COG2318	DinB family
MID01_RS16955	COG1454	alcohol dehydrogenase
MID01_RS16960	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS16965	COG1510	regulation of RNA biosynthetic process
MID01_RS16975	COG0569	domain protein
MID01_RS16980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MID01_RS16985	COG4682	membrane
MID01_RS16990	COG1705	Flagellar rod assembly protein muramidase FlgJ
MID01_RS16995	COG0477	Major facilitator Superfamily
MID01_RS17010	COG1968	undecaprenyl-diphosphatase activity
MID01_RS17015	COG0628	permease
MID01_RS17020	COG0673	inositol 2-dehydrogenase activity
MID01_RS17025	COG4806	L-rhamnose isomerase
MID01_RS17030	COG3254	rhamnose metabolic process
MID01_RS17035	COG1070	Carbohydrate kinase
MID01_RS17040	COG1349	DNA-binding transcription factor activity
MID01_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS17045	COG3347	Dehydrogenase
MID01_RS17050	COG0840	transmembrane signaling receptor activity
MID01_RS17055	COG0840	transmembrane signaling receptor activity
MID01_RS17060	COG0840	transmembrane signaling receptor activity
MID01_RS17065	COG0840	transmembrane signaling receptor activity
MID01_RS17080	COG0432	Pfam Uncharacterised protein family UPF0047
MID01_RS17090	COG0366	Alpha amylase catalytic
MID01_RS17095	COG1253	flavin adenine dinucleotide binding
MID01_RS17100	COG2738	Putative neutral zinc metallopeptidase
MID01_RS17115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MID01_RS17130	COG0166	Belongs to the GPI family
MID01_RS17135	COG1979	alcohol dehydrogenase
MID01_RS17140	COG1979	alcohol dehydrogenase
MID01_RS17145	COG2155	Conserved Protein
MID01_RS17150	COG1098	S1 RNA binding domain
MID01_RS17155	COG0436	Aminotransferase
MID01_RS17160	COG1522	sequence-specific DNA binding
MID01_RS17165	COG2267	carboxylic ester hydrolase activity
MID01_RS17175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MID01_RS17180	COG2205	protein histidine kinase activity
MID01_RS17190	COG5018	Exonuclease
MID01_RS17200	COG2814	Major facilitator Superfamily
MID01_RS17205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID01_RS17210	COG3011	Protein conserved in bacteria
MID01_RS17220	COG3290	protein histidine kinase activity
MID01_RS17225	COG4565	transcriptional regulatory protein
MID01_RS17230	COG1744	ABC transporter substrate-binding protein PnrA-like
MID01_RS17235	COG3845	ABC transporter
MID01_RS17240	COG4603	Belongs to the binding-protein-dependent transport system permease family
MID01_RS17245	COG1079	Belongs to the binding-protein-dependent transport system permease family
MID01_RS17250	COG3493	citrate carrier protein
MID01_RS17260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MID01_RS17260	COG2111	Na H antiporter
MID01_RS17265	COG2111	Na H antiporter
MID01_RS17270	COG1006	Multisubunit Na H antiporter MnhC subunit
MID01_RS17275	COG0651	ATP synthesis coupled electron transport
MID01_RS17280	COG1863	multisubunit Na H antiporter MnhE subunit
MID01_RS17285	COG2212	antiporter activity
MID01_RS17290	COG1320	monovalent cation:proton antiporter activity
MID01_RS17295	COG2050	protein possibly involved in aromatic compounds catabolism
MID01_RS17305	COG4585	Histidine kinase
MID01_RS17315	COG0142	geranyltranstransferase activity
MID01_RS17335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MID01_RS17340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MID01_RS17345	COG1335	isochorismatase
MID01_RS17350	COG5506	Protein of unknown function (DUF1694)
MID01_RS17365	COG0628	permease
MID01_RS17380	COG1418	mRNA catabolic process
MID01_RS17385	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS17395	COG1511	domain protein
MID01_RS17400	COG0433	COG0433 Predicted ATPase
MID01_RS17400	COG1674	ftsk spoiiie
MID01_RS17405	COG4499	WXG100 protein secretion system (Wss), protein YukC
MID01_RS17410	COG5417	Belongs to the EsaB family
MID01_RS17415	COG4842	Belongs to the WXG100 family
MID01_RS17420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MID01_RS17420	COG2508	Transcriptional regulator
MID01_RS17425	COG0686	Belongs to the AlaDH PNT family
MID01_RS17430	COG5634	Uncharacterized conserved protein (DUF2278)
MID01_RS17435	COG3251	PFAM MbtH domain protein
MID01_RS17440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS17445	COG1535	isochorismatase
MID01_RS17445	COG3433	isochorismatase activity
MID01_RS17450	COG1021	2,3-dihydroxybenzoate-AMP ligase
MID01_RS17455	COG1169	isochorismate synthase
MID01_RS17460	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS17465	COG2819	hydrolase of the alpha beta superfamily
MID01_RS17470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MID01_RS17475	COG1268	BioY protein
MID01_RS17480	COG2056	Na+-H+ antiporter family
MID01_RS17485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MID01_RS17490	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MID01_RS17495	COG3584	3D domain protein
MID01_RS17510	COG1252	NADH dehydrogenase
MID01_RS17515	COG0492	ferredoxin-NADP+ reductase activity
MID01_RS17525	COG0516	GMP reductase activity
MID01_RS17530	COG2808	Putative FMN-binding domain
MID01_RS17535	COG0456	acetyltransferase
MID01_RS17540	COG0316	Belongs to the HesB IscA family
MID01_RS17545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MID01_RS17550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MID01_RS17555	COG4844	belongs to the
MID01_RS17560	COG1252	NADH dehydrogenase
MID01_RS17565	COG4837	Protein of unknown function (DUF1462)
MID01_RS17570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MID01_RS17575	COG4946	Tricorn protease homolog
MID01_RS17575	COG1506	peptidase
MID01_RS17575	COG0823	Involved in the tonB-independent uptake of proteins
MID01_RS17580	COG0083	homoserine kinase activity
MID01_RS17585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MID01_RS17590	COG0460	homoserine dehydrogenase
MID01_RS17595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MID01_RS17600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MID01_RS17605	COG0647	UMP catabolic process
MID01_RS17610	COG2445	Protein of unknown function DUF86
MID01_RS17615	COG4470	Protein conserved in bacteria
MID01_RS17625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MID01_RS17630	COG0739	heme binding
MID01_RS17640	COG3377	Domain of unknown function (DUF1805)
MID01_RS17645	COG0737	Belongs to the 5'-nucleotidase family
MID01_RS17650	COG0730	response to heat
MID01_RS17655	COG1801	Protein of unknown function DUF72
MID01_RS17665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MID01_RS17670	COG2508	Transcriptional regulator
MID01_RS17675	COG2233	PERMEase
MID01_RS17680	COG2233	PERMEase
MID01_RS17685	COG3648	Uricase
MID01_RS17685	COG3195	allantoin biosynthetic process
MID01_RS17690	COG2351	hydroxyisourate hydrolase activity
MID01_RS17700	COG2080	2 iron, 2 sulfur cluster binding
MID01_RS17705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MID01_RS17710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MID01_RS17715	COG2068	MobA-Related Protein
MID01_RS17720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MID01_RS17725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MID01_RS17730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MID01_RS17740	COG2356	endonuclease I
MID01_RS17745	COG3842	ATPase activity
MID01_RS17750	COG2188	Transcriptional regulator
MID01_RS17755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID01_RS17760	COG0395	ABC-type sugar transport system, permease component
MID01_RS17765	COG1175	transmembrane transport
MID01_RS17770	COG1653	transport
MID01_RS17775	COG2222	sugar isomerase
MID01_RS17780	COG0322	excinuclease ABC activity
MID01_RS17785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MID01_RS17800	COG0346	lactoylglutathione lyase activity
MID01_RS17805	COG0640	Transcriptional regulator
MID01_RS17810	COG0719	Fe-S assembly protein
MID01_RS17815	COG0822	iron-sulfur transferase activity
MID01_RS17820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MID01_RS17825	COG0719	Fe-S assembly protein
MID01_RS17830	COG0396	ATPase activity
MID01_RS17840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MID01_RS17845	COG1464	Belongs to the NlpA lipoprotein family
MID01_RS17850	COG2011	ABC-type metal ion transport system permease component
MID01_RS17855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MID01_RS17865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MID01_RS17870	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MID01_RS17880	COG0509	glycine decarboxylation via glycine cleavage system
MID01_RS17885	COG1393	Belongs to the ArsC family
MID01_RS17890	COG1960	acyl-CoA dehydrogenase activity
MID01_RS17895	COG0183	Belongs to the thiolase family
MID01_RS17900	COG1024	Enoyl-CoA hydratase
MID01_RS17900	COG1250	3-hydroxyacyl-CoA dehydrogenase
MID01_RS17910	COG0506	proline dehydrogenase activity
MID01_RS17920	COG5577	PFAM Coat F domain
MID01_RS17925	COG1846	Transcriptional regulator
MID01_RS17930	COG0477	Major facilitator Superfamily
MID01_RS17935	COG1942	4-Oxalocrotonate Tautomerase
MID01_RS17945	COG0583	DNA-binding transcription factor activity
MID01_RS17955	COG1120	ATPase activity
MID01_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS17975	COG0783	Belongs to the Dps family
MID01_RS17980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID01_RS17985	COG0745	RESPONSE REGULATOR receiver
MID01_RS17990	COG2205	protein histidine kinase activity
MID01_RS17990	COG2770	Histidine kinase
MID01_RS18000	COG1309	transcriptional regulator
MID01_RS18005	COG0114	fumarate hydratase activity
MID01_RS18015	COG0697	spore germination
MID01_RS18020	COG0814	amino acid
MID01_RS18030	COG2197	response regulator
MID01_RS18035	COG4585	Histidine kinase
MID01_RS18040	COG4758	membrane
MID01_RS18045	COG3595	metallopeptidase activity
MID01_RS18050	COG1842	Phage shock protein A
MID01_RS18055	COG4758	membrane
MID01_RS18060	COG2814	Major facilitator Superfamily
MID01_RS18065	COG2096	Adenosyltransferase
MID01_RS18070	COG1120	ATPase activity
MID01_RS18075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS18080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS18090	COG3386	PFAM SMP-30 Gluconolaconase
MID01_RS18095	COG2205	protein histidine kinase activity
MID01_RS18100	COG0745	RESPONSE REGULATOR receiver
MID01_RS18110	COG1191	sigma factor activity
MID01_RS18120	COG2140	Oxalate decarboxylase
MID01_RS18130	COG0577	efflux transmembrane transporter activity
MID01_RS18135	COG1136	(ABC) transporter
MID01_RS18140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MID01_RS18145	COG1120	ATPase activity
MID01_RS18150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS18155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MID01_RS18160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS18165	COG0531	amino acid
MID01_RS18175	COG1988	membrane-bound metal-dependent
MID01_RS18180	COG1368	sulfuric ester hydrolase activity
MID01_RS18185	COG1910	domain protein
MID01_RS18190	COG0725	ABC transporter, periplasmic molybdate-binding protein
MID01_RS18195	COG4149	molybdate abc transporter
MID01_RS18200	COG0656	L-ascorbic acid biosynthetic process
MID01_RS18210	COG0025	NhaP-type Na H and K H
MID01_RS18215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MID01_RS18220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MID01_RS18225	COG3973	AAA domain
MID01_RS18235	COG2860	membrane
MID01_RS18240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MID01_RS18245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MID01_RS18250	COG2217	Heavy metal translocating P-type atpase
MID01_RS18255	COG2217	Heavy metal translocating P-type atpase
MID01_RS18260	COG2608	mercury ion transmembrane transporter activity
MID01_RS18265	COG1937	Protein conserved in bacteria
MID01_RS18270	COG0673	inositol 2-dehydrogenase activity
MID01_RS18275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MID01_RS18280	COG1289	transmembrane transporter activity
MID01_RS18290	COG2076	Multidrug Resistance protein
MID01_RS18295	COG1309	transcriptional regulator
MID01_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS18325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MID01_RS18330	COG0557	exoribonuclease II activity
MID01_RS18335	COG1647	Serine aminopeptidase, S33
MID01_RS18340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MID01_RS18345	COG0596	Alpha beta hydrolase
MID01_RS18350	COG1476	TRANSCRIPTIONal
MID01_RS18355	COG1396	sequence-specific DNA binding
MID01_RS18360	COG1396	sequence-specific DNA binding
MID01_RS18365	COG1733	regulation of RNA biosynthetic process
MID01_RS18370	COG0840	transmembrane signaling receptor activity
MID01_RS18395	COG1131	(ABC) transporter
MID01_RS18425	COG1174	glycine betaine transport
MID01_RS18430	COG1732	Glycine betaine
MID01_RS18435	COG1174	glycine betaine transport
MID01_RS18440	COG0517	IMP dehydrogenase activity
MID01_RS18440	COG1125	glycine betaine transport
MID01_RS18445	COG1510	regulation of RNA biosynthetic process
MID01_RS18450	COG1174	glycine betaine transport
MID01_RS18455	COG1732	Glycine betaine
MID01_RS18460	COG1174	glycine betaine transport
MID01_RS18465	COG0517	IMP dehydrogenase activity
MID01_RS18465	COG1125	glycine betaine transport
MID01_RS18470	COG1510	regulation of RNA biosynthetic process
MID01_RS18475	COG2095	MarC family integral membrane protein
MID01_RS18485	COG3064	Membrane
MID01_RS18490	COG4640	response to antibiotic
MID01_RS18495	COG0456	acetyltransferase
MID01_RS18500	COG0148	phosphopyruvate hydratase activity
MID01_RS18505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MID01_RS18510	COG0149	triose-phosphate isomerase activity
MID01_RS18515	COG0126	phosphoglycerate kinase activity
MID01_RS18520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MID01_RS18525	COG2390	Transcriptional regulator
MID01_RS18530	COG2814	Major facilitator Superfamily
MID01_RS18535	COG1609	Transcriptional regulator
MID01_RS18540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS18545	COG0583	DNA-binding transcription factor activity
MID01_RS18550	COG0697	spore germination
MID01_RS18555	COG1113	amino acid transport
MID01_RS18560	COG3858	chitin binding
MID01_RS18565	COG1556	Lactate utilization protein
MID01_RS18570	COG1139	Iron-sulfur cluster binding protein
MID01_RS18575	COG0247	lactate metabolic process
MID01_RS18580	COG2197	response regulator
MID01_RS18585	COG4585	Histidine kinase
MID01_RS18590	COG0842	Transport permease protein
MID01_RS18595	COG1131	(ABC) transporter
MID01_RS18600	COG0596	Alpha beta hydrolase
MID01_RS18605	COG2208	phosphoserine phosphatase activity
MID01_RS18610	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MID01_RS18615	COG1874	Beta-galactosidase
MID01_RS18620	COG3833	ABC-type maltose transport systems, permease component
MID01_RS18625	COG1175	transmembrane transport
MID01_RS18630	COG2182	Extracellular solute-binding protein
MID01_RS18635	COG1609	Transcriptional regulator
MID01_RS18640	COG2186	Transcriptional regulator
MID01_RS18645	COG1620	l-lactate permease
MID01_RS18650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MID01_RS18655	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MID01_RS18665	COG5039	Polysaccharide pyruvyl transferase
MID01_RS18670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MID01_RS18675	COG0110	maltose O-acetyltransferase activity
MID01_RS18680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MID01_RS18685	COG2244	polysaccharide biosynthetic process
MID01_RS18690	COG1216	Glycosyl transferase, family 2
MID01_RS18695	COG5039	Polysaccharide pyruvyl transferase
MID01_RS18700	COG1216	Glycosyl transferase, family 2
MID01_RS18710	COG0438	transferase activity, transferring glycosyl groups
MID01_RS18715	COG1215	transferase activity, transferring glycosyl groups
MID01_RS18720	COG0438	transferase activity, transferring glycosyl groups
MID01_RS18725	COG1086	Polysaccharide biosynthesis protein
MID01_RS18730	COG0489	protein tyrosine kinase activity
MID01_RS18740	COG1396	sequence-specific DNA binding
MID01_RS18745	COG2272	Belongs to the type-B carboxylesterase lipase family
MID01_RS18755	COG3479	Phenolic acid decarboxylase
MID01_RS18765	COG1794	racemase activity, acting on amino acids and derivatives
MID01_RS18770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MID01_RS18775	COG1621	beta-fructofuranosidase activity
MID01_RS18780	COG1621	beta-fructofuranosidase activity
MID01_RS18785	COG0531	amino acid
MID01_RS18790	COG1309	transcriptional regulator
MID01_RS18795	COG2076	Multidrug Resistance protein
MID01_RS18800	COG2076	Multidrug Resistance protein
MID01_RS18815	COG0740	serine-type endopeptidase activity
MID01_RS18820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MID01_RS18825	COG0366	Alpha amylase catalytic
MID01_RS18830	COG1554	hydrolase, family 65, central catalytic
MID01_RS18835	COG5521	maltodextrose utilization protein MalA
MID01_RS18840	COG3833	ABC-type maltose transport systems, permease component
MID01_RS18845	COG1175	transmembrane transport
MID01_RS18850	COG2182	Extracellular solute-binding protein
MID01_RS18855	COG0366	Alpha amylase catalytic
MID01_RS18860	COG1609	Transcriptional regulator
MID01_RS18865	COG1611	Belongs to the LOG family
MID01_RS18870	COG1694	Mazg nucleotide pyrophosphohydrolase
MID01_RS18875	COG0659	secondary active sulfate transmembrane transporter activity
MID01_RS18880	COG0288	reversible hydration of carbon dioxide
MID01_RS18885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MID01_RS18890	COG0577	efflux transmembrane transporter activity
MID01_RS18895	COG1136	(ABC) transporter
MID01_RS18900	COG5002	protein histidine kinase activity
MID01_RS18905	COG0745	RESPONSE REGULATOR receiver
MID01_RS18920	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MID01_RS18925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS18930	COG1481	regulation of sporulation
MID01_RS18935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MID01_RS18940	COG1660	Displays ATPase and GTPase activities
MID01_RS18945	COG1051	belongs to the nudix hydrolase family
MID01_RS18950	COG0492	ferredoxin-NADP+ reductase activity
MID01_RS18955	COG3883	PFAM NLP P60 protein
MID01_RS18955	COG0791	NLP P60 protein
MID01_RS18960	COG0457	Tetratricopeptide repeat
MID01_RS18965	COG1132	(ABC) transporter
MID01_RS18985	COG0140	phosphoribosyl-ATP diphosphatase activity
MID01_RS18985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MID01_RS18990	COG0107	imidazoleglycerol-phosphate synthase activity
MID01_RS18995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MID01_RS19000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MID01_RS19005	COG0131	Imidazoleglycerol-phosphate dehydratase
MID01_RS19010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MID01_RS19015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MID01_RS19020	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MID01_RS19025	COG4990	cell redox homeostasis
MID01_RS19030	COG5297	Belongs to the glycosyl hydrolase family 6
MID01_RS19035	COG0110	maltose O-acetyltransferase activity
MID01_RS19040	COG0546	phosphoglycolate phosphatase activity
MID01_RS19045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MID01_RS19050	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MID01_RS19055	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MID01_RS19060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MID01_RS19065	COG0363	glucosamine-6-phosphate deaminase activity
MID01_RS19070	COG2188	Transcriptional regulator
MID01_RS19075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MID01_RS19080	COG1846	Transcriptional regulator
MID01_RS19095	COG1846	Transcriptional regulator
MID01_RS19100	COG2814	Major facilitator Superfamily
MID01_RS19105	COG1950	PFAM Membrane protein of
MID01_RS19110	COG1983	PspC domain protein
MID01_RS19115	COG3595	metallopeptidase activity
MID01_RS19135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MID01_RS19140	COG0556	nucleotide-excision repair
MID01_RS19145	COG4897	Protein conserved in bacteria
MID01_RS19150	COG0574	Belongs to the PEP-utilizing enzyme family
MID01_RS19150	COG3848	Pyruvate phosphate dikinase
MID01_RS19155	COG1309	transcriptional regulator
MID01_RS19160	COG2814	Major facilitator Superfamily
MID01_RS19165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID01_RS19175	COG3409	Peptidoglycan-binding domain 1 protein
MID01_RS19175	COG0793	Belongs to the peptidase S41A family
MID01_RS19180	COG2177	Part of the ABC transporter FtsEX involved in
MID01_RS19185	COG2884	Cell division ATP-binding protein ftsE
MID01_RS19190	COG2010	Cytochrome c
MID01_RS19195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS19205	COG0653	protein targeting
MID01_RS19210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MID01_RS19225	COG1516	flagellar protein fliS
MID01_RS19230	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MID01_RS19235	COG1334	flagellar protein FlaG
MID01_RS19240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MID01_RS19245	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MID01_RS19250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MID01_RS19260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MID01_RS19265	COG4786	Flagellar basal body rod
MID01_RS19265	COG1256	bacterial-type flagellum assembly
MID01_RS19270	COG3418	PFAM FlgN family protein
MID01_RS19275	COG2747	anti-sigma28 factor FlgM
MID01_RS19285	COG1040	competence protein
MID01_RS19295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MID01_RS19300	COG1307	EDD domain protein, DegV family
MID01_RS19305	COG2197	response regulator
MID01_RS19310	COG4585	Histidine kinase
MID01_RS19315	COG1739	Uncharacterized protein family UPF0029
MID01_RS19320	COG1316	TRANSCRIPTIONal
MID01_RS19325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MID01_RS19330	COG0438	transferase activity, transferring glycosyl groups
MID01_RS19335	COG1215	transferase activity, transferring glycosyl groups
MID01_RS19340	COG3206	protein involved in exopolysaccharide biosynthesis
MID01_RS19345	COG3307	-O-antigen
MID01_RS19350	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MID01_RS19355	COG0297	glycogen (starch) synthase activity
MID01_RS19355	COG0438	transferase activity, transferring glycosyl groups
MID01_RS19360	COG2244	polysaccharide biosynthetic process
MID01_RS19375	COG2247	cell wall binding repeat
MID01_RS19375	COG0860	N-Acetylmuramoyl-L-alanine amidase
MID01_RS19380	COG2247	cell wall binding repeat
MID01_RS19380	COG2385	sporulation resulting in formation of a cellular spore
MID01_RS19390	COG1316	TRANSCRIPTIONal
MID01_RS19395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MID01_RS19415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MID01_RS19420	COG1134	teichoic acid transport
MID01_RS19425	COG1682	transport, permease protein
MID01_RS19430	COG1215	transferase activity, transferring glycosyl groups
MID01_RS19430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MID01_RS19435	COG0463	Glycosyl transferase, family 2
MID01_RS19480	COG4193	domain, Protein
MID01_RS19485	COG1482	cell wall glycoprotein biosynthetic process
MID01_RS19490	COG0697	spore germination
MID01_RS19495	COG0814	amino acid
MID01_RS19505	COG2814	Major facilitator Superfamily
MID01_RS19510	COG1316	TRANSCRIPTIONal
MID01_RS19515	COG0561	phosphatase activity
MID01_RS19520	COG0791	NLP P60 protein
MID01_RS19530	COG2843	Capsule synthesis protein
MID01_RS19540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MID01_RS19545	COG1609	Transcriptional regulator
MID01_RS19550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID01_RS19555	COG1869	D-ribose catabolic process
MID01_RS19560	COG1129	ABC transporter
MID01_RS19565	COG1172	Belongs to the binding-protein-dependent transport system permease family
MID01_RS19570	COG1879	ABC-type sugar transport system periplasmic component
MID01_RS19575	COG3103	Sh3 type 3 domain protein
MID01_RS19585	COG2249	NAD(P)H dehydrogenase (quinone) activity
MID01_RS19590	COG3527	Alpha-acetolactate decarboxylase
MID01_RS19595	COG0028	Belongs to the TPP enzyme family
MID01_RS19600	COG0583	DNA-binding transcription factor activity
MID01_RS19605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MID01_RS19620	COG5337	Spore coat protein CotH
MID01_RS19640	COG0405	Gamma-glutamyltransferase
MID01_RS19645	COG1522	sequence-specific DNA binding
MID01_RS19650	COG2059	Chromate
MID01_RS19655	COG2059	Chromate
MID01_RS19670	COG5444	nuclease activity
MID01_RS19690	COG3878	Protein conserved in bacteria
MID01_RS19695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MID01_RS19700	COG4464	protein tyrosine phosphatase activity
MID01_RS19705	COG0489	protein tyrosine kinase activity
MID01_RS19710	COG3944	biosynthesis protein
MID01_RS19720	COG4715	Zinc finger, swim domain protein
MID01_RS19725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MID01_RS19730	COG0561	phosphatase activity
MID01_RS19735	COG1349	DNA-binding transcription factor activity
MID01_RS19740	COG0629	single-stranded DNA binding
MID01_RS19755	COG3764	Sortase (surface protein transpeptidase)
MID01_RS19765	COG3279	Response regulator of the LytR AlgR family
MID01_RS19775	COG0745	RESPONSE REGULATOR receiver
MID01_RS19775	COG2972	Histidine kinase
MID01_RS19780	COG1970	mechanosensitive ion channel activity
MID01_RS19785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MID01_RS19790	COG0457	Tetratricopeptide repeat
MID01_RS19795	COG4786	Flagellar basal body rod
MID01_RS19800	COG4786	Flagellar basal body rod
MID01_RS19805	COG1077	Cell shape determining protein MreB Mrl
MID01_RS19810	COG1609	Transcriptional regulator
MID01_RS19820	COG1846	Transcriptional regulator
MID01_RS19825	COG2814	Major facilitator Superfamily
MID01_RS19830	COG3420	alginic acid biosynthetic process
MID01_RS19835	COG1953	Uracil, thiamine, allantoin
MID01_RS19840	COG0477	Major facilitator Superfamily
MID01_RS19845	COG1335	isochorismatase
MID01_RS19855	COG0004	ammonium transporteR
MID01_RS19860	COG0347	Belongs to the P(II) protein family
MID01_RS19865	COG0671	phosphoesterase, PA-phosphatase related
MID01_RS19875	COG0739	heme binding
MID01_RS19880	COG1247	-acetyltransferase
MID01_RS19900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MID01_RS19905	COG0789	Transcriptional regulator
MID01_RS19915	COG2910	NAD(P)H-binding
MID01_RS19920	COG1959	2 iron, 2 sulfur cluster binding
MID01_RS19925	COG0804	urea catabolic process
MID01_RS19930	COG0832	Belongs to the urease beta subunit family
MID01_RS19935	COG0831	urea catabolic process
MID01_RS19950	COG3237	CsbD-like
MID01_RS19955	COG1994	Peptidase M50
MID01_RS19960	COG0457	Tetratricopeptide repeat
MID01_RS19965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MID01_RS19970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MID01_RS19980	COG2304	oxidoreductase activity
MID01_RS19990	COG2304	oxidoreductase activity
MID01_RS19995	COG2385	sporulation resulting in formation of a cellular spore
MID01_RS20000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MID01_RS20010	COG4836	Membrane
MID01_RS20020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MID01_RS20025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MID01_RS20030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MID01_RS20035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MID01_RS20040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MID01_RS20045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MID01_RS20055	COG0356	it plays a direct role in the translocation of protons across the membrane
MID01_RS20065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MID01_RS20070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MID01_RS20075	COG4475	Protein of unknown function (DUF436)
MID01_RS20080	COG0698	ribose 5-phosphate isomerase
MID01_RS20085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MID01_RS20090	COG1971	Probably functions as a manganese efflux pump
MID01_RS20095	COG0009	L-threonylcarbamoyladenylate synthase
MID01_RS20100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MID01_RS20120	COG2890	protein-(glutamine-N5) methyltransferase activity
MID01_RS20125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MID01_RS20130	COG0346	lactoylglutathione lyase activity
MID01_RS20135	COG0789	Transcriptional regulator
MID01_RS20140	COG0679	Auxin Efflux Carrier
MID01_RS20145	COG0281	malic enzyme
MID01_RS20150	COG1435	thymidine kinase activity
MID01_RS20160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MID01_RS20170	COG1494	fructose-1,6-bisphosphatase
MID01_RS20175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MID01_RS20180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MID01_RS20185	COG0191	fructose-bisphosphate aldolase activity
MID01_RS20190	COG2204	response regulator
MID01_RS20195	COG4821	SIS domain
MID01_RS20200	COG0504	CTP synthase activity
MID01_RS20205	COG3343	RNA polymerase activity
MID01_RS20210	COG1960	acyl-CoA dehydrogenase activity
MID01_RS20215	COG2181	nitrate reductase activity
MID01_RS20215	COG0247	lactate metabolic process
MID01_RS20220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MID01_RS20225	COG4294	response to UV
MID01_RS20235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MID01_RS20240	COG1132	(ABC) transporter
MID01_RS20245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MID01_RS20255	COG2181	nitrate reductase activity
MID01_RS20260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MID01_RS20265	COG1140	nitrate reductase beta subunit
MID01_RS20270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MID01_RS20275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MID01_RS20285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MID01_RS20290	COG2223	nitrite transmembrane transporter activity
MID01_RS20295	COG0018	arginyl-trna synthetase
MID01_RS20300	COG4506	Protein conserved in bacteria
MID01_RS20315	COG0535	radical SAM domain protein
MID01_RS20325	COG1131	(ABC) transporter
MID01_RS20330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MID01_RS20335	COG0612	Peptidase, M16
MID01_RS20340	COG0612	Peptidase, M16
MID01_RS20350	COG3391	amine dehydrogenase activity
MID01_RS20355	COG3391	amine dehydrogenase activity
MID01_RS20360	COG0457	Tetratricopeptide repeat
MID01_RS20390	COG1131	(ABC) transporter
MID01_RS20400	COG0010	Belongs to the arginase family
MID01_RS20405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MID01_RS20410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MID01_RS20425	COG1994	Peptidase M50
MID01_RS20430	COG1942	4-Oxalocrotonate Tautomerase
MID01_RS20435	COG1846	Transcriptional regulator
MID01_RS20440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MID01_RS20445	COG0477	Major facilitator Superfamily
MID01_RS20450	COG1959	2 iron, 2 sulfur cluster binding
MID01_RS20455	COG3465	dGTPase activity
MID01_RS20460	COG1078	dGTPase activity
MID01_RS20465	COG4844	belongs to the
MID01_RS20475	COG0697	spore germination
MID01_RS20480	COG0095	Lipoate-protein ligase
MID01_RS20485	COG0583	DNA-binding transcription factor activity
MID01_RS20490	COG0280	phosphate acetyltransferase
MID01_RS20495	COG3253	May function as heme-dependent peroxidase
MID01_RS20500	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS20505	COG0436	Aminotransferase
MID01_RS20510	COG2814	Major facilitator Superfamily
MID01_RS20515	COG0151	Belongs to the GarS family
MID01_RS20520	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS20525	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS20530	COG0077	Prephenate dehydratase
MID01_RS20535	COG2814	Major facilitator Superfamily
MID01_RS20540	COG0833	amino acid
MID01_RS20545	COG4187	Peptidase family M20/M25/M40
MID01_RS20550	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS20555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MID01_RS20565	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MID01_RS20570	COG1091	dTDP-4-dehydrorhamnose reductase activity
MID01_RS20575	COG1088	dTDP-glucose 4,6-dehydratase activity
MID01_RS20580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MID01_RS20585	COG3980	spore coat polysaccharide biosynthesis protein
MID01_RS20590	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MID01_RS20595	COG2089	acid synthase
MID01_RS20600	COG0456	acetyltransferase
MID01_RS20605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MID01_RS20610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MID01_RS20615	COG0463	Glycosyl transferase, family 2
MID01_RS20625	COG2363	Small membrane protein
MID01_RS20630	COG2233	PERMEase
MID01_RS20640	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS20645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MID01_RS20650	COG1216	Glycosyl transferase, family 2
MID01_RS20665	COG1695	Transcriptional regulator
MID01_RS20670	COG0351	phosphomethylpyrimidine kinase
MID01_RS20680	COG1621	beta-fructofuranosidase activity
MID01_RS20685	COG1263	PTS System
MID01_RS20685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS20690	COG2116	formate transmembrane transporter activity
MID01_RS20695	COG3711	transcriptional antiterminator
MID01_RS20705	COG1404	Belongs to the peptidase S8 family
MID01_RS20710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS20715	COG0778	Nitroreductase
MID01_RS20720	COG0772	Belongs to the SEDS family
MID01_RS20730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MID01_RS20735	COG1845	cytochrome c oxidase, subunit III
MID01_RS20740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MID01_RS20745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MID01_RS20750	COG2261	transglycosylase associated protein
MID01_RS20755	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MID01_RS20760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MID01_RS20765	COG2246	polysaccharide biosynthetic process
MID01_RS20770	COG1309	transcriptional regulator
MID01_RS20780	COG3162	membrane
MID01_RS20785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MID01_RS20790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MID01_RS20795	COG2837	iron assimilation
MID01_RS20800	COG2822	iron ion transport
MID01_RS20805	COG0672	)-iron permease
MID01_RS20810	COG0352	thiamine-phosphate diphosphorylase activity
MID01_RS20815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MID01_RS20820	COG0583	DNA-binding transcription factor activity
MID01_RS20825	COG1380	Effector of murein hydrolase LrgA
MID01_RS20830	COG1346	cytolysis
MID01_RS20835	COG2814	Major facilitator Superfamily
MID01_RS20840	COG4895	conserved protein (DUF2196)
MID01_RS20845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MID01_RS20850	COG0346	lactoylglutathione lyase activity
MID01_RS20875	COG1404	Belongs to the peptidase S8 family
MID01_RS20880	COG1263	PTS System
MID01_RS20880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS20885	COG3711	transcriptional antiterminator
MID01_RS20890	COG1442	glycosyl transferase family 8
MID01_RS20895	COG5522	Integral membrane protein (intg_mem_TP0381)
MID01_RS20900	COG1846	Transcriptional regulator
MID01_RS20905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MID01_RS20910	COG2234	aminopeptidase activity
MID01_RS20925	COG2814	Major facilitator Superfamily
MID01_RS20930	COG2357	RelA SpoT domain protein
MID01_RS20935	COG1575	Belongs to the MenA family. Type 1 subfamily
MID01_RS20950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MID01_RS20955	COG1696	Membrane protein involved in D-alanine export
MID01_RS20960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MID01_RS20965	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MID01_RS20970	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MID01_RS20975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MID01_RS20980	COG1486	melibiose metabolic process
MID01_RS20985	COG1447	Phosphotransferase system cellobiose-specific component IIA
MID01_RS20990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MID01_RS20995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MID01_RS21000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MID01_RS21000	COG3711	transcriptional antiterminator
MID01_RS21010	COG2094	Belongs to the DNA glycosylase MPG family
MID01_RS21015	COG0753	catalase activity
MID01_RS21020	COG2814	Major facilitator Superfamily
MID01_RS21025	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MID01_RS21030	COG1131	(ABC) transporter
MID01_RS21050	COG1595	DNA-templated transcription, initiation
MID01_RS21055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MID01_RS21060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MID01_RS21065	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MID01_RS21070	COG4988	ABC transporter
MID01_RS21075	COG1294	oxidase, subunit
MID01_RS21080	COG1271	oxidase subunit
MID01_RS21085	COG3493	citrate carrier protein
MID01_RS21090	COG0501	Belongs to the peptidase M48B family
MID01_RS21100	COG0726	polysaccharide deacetylase
MID01_RS21115	COG3842	ATPase activity
MID01_RS21120	COG2508	Transcriptional regulator
MID01_RS21125	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS21130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MID01_RS21140	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MID01_RS21145	COG1881	PFAM PEBP family protein
MID01_RS21150	COG0583	DNA-binding transcription factor activity
MID01_RS21160	COG4585	Histidine kinase
MID01_RS21165	COG2197	response regulator
MID01_RS21170	COG2195	Cleaves the N-terminal amino acid of tripeptides
MID01_RS21180	COG4894	glucomannan catabolic process
MID01_RS21185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MID01_RS21190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MID01_RS21195	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS21200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MID01_RS21205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MID01_RS21210	COG2610	gluconate transmembrane transporter activity
MID01_RS21215	COG0500	methyltransferase
MID01_RS21220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MID01_RS21235	COG0693	protein deglycase activity
MID01_RS21235	COG0753	catalase activity
MID01_RS21240	COG2851	Citrate transporter
MID01_RS21245	COG2273	Hydrolase Family 16
MID01_RS21250	COG3711	transcriptional antiterminator
MID01_RS21260	COG2270	Major facilitator Superfamily
MID01_RS21265	COG0513	Belongs to the DEAD box helicase family
MID01_RS21270	COG2755	lipolytic protein G-D-S-L family
MID01_RS21270	COG3401	FG-GAP repeat protein
MID01_RS21315	COG3209	COG3209 Rhs family protein
MID01_RS21320	COG0697	spore germination
MID01_RS21325	COG0589	response to stress
MID01_RS21330	COG2723	6-phospho-beta-galactosidase activity
MID01_RS21335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS21335	COG2190	(PTS) system
MID01_RS21335	COG1263	PTS System
MID01_RS21380	COG3507	Belongs to the glycosyl hydrolase 43 family
MID01_RS21395	COG2986	histidine ammonia-lyase
MID01_RS21400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MID01_RS21405	COG1228	amidohydrolase
MID01_RS21410	COG0010	Belongs to the arginase family
MID01_RS21415	COG0833	amino acid
MID01_RS21420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MID01_RS21425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MID01_RS21430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MID01_RS21435	COG2390	Transcriptional regulator
MID01_RS21445	COG3192	ethanolamine utilization protein
MID01_RS21450	COG2079	MmgE PrpD family protein
MID01_RS21455	COG1473	amidohydrolase
MID01_RS21460	COG1126	abc transporter atp-binding protein
MID01_RS21465	COG0765	amino acid transport
MID01_RS21470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MID01_RS21475	COG0456	acetyltransferase
MID01_RS21480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MID01_RS21485	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MID01_RS21490	COG0561	phosphatase activity
MID01_RS21520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MID01_RS21525	COG5294	Protein conserved in bacteria
MID01_RS21530	COG0577	efflux transmembrane transporter activity
MID01_RS21535	COG1136	(ABC) transporter
MID01_RS21540	COG2205	protein histidine kinase activity
MID01_RS21545	COG0745	RESPONSE REGULATOR receiver
MID01_RS21550	COG0191	fructose-bisphosphate aldolase activity
MID01_RS21555	COG1082	Xylose isomerase domain protein TIM barrel
MID01_RS21560	COG1082	Xylose isomerase domain protein TIM barrel
MID01_RS21565	COG0673	inositol 2-dehydrogenase activity
MID01_RS21570	COG2814	Major facilitator Superfamily
MID01_RS21575	COG1082	Xylose isomerase domain protein TIM barrel
MID01_RS21580	COG3962	Belongs to the TPP enzyme family
MID01_RS21585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MID01_RS21595	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS21600	COG1349	DNA-binding transcription factor activity
MID01_RS21605	COG0667	Aldo Keto reductase
MID01_RS21620	COG2814	Major facilitator Superfamily
MID01_RS21625	COG0326	Molecular chaperone. Has ATPase activity
MID01_RS21635	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS21660	COG1309	transcriptional regulator
MID01_RS21665	COG1012	belongs to the aldehyde dehydrogenase family
MID01_RS21670	COG1714	RDD family
MID01_RS21675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MID01_RS21685	COG1714	RDD family
MID01_RS21690	COG2311	Membrane
MID01_RS21695	COG1917	Cupin 2, conserved barrel domain protein
MID01_RS21700	COG1309	transcriptional regulator
MID01_RS21705	COG1028	Short-chain dehydrogenase reductase Sdr
MID01_RS21710	COG1846	Transcriptional regulator
MID01_RS21715	COG1380	Effector of murein hydrolase LrgA
MID01_RS21720	COG1346	cytolysis
MID01_RS21725	COG5039	Polysaccharide pyruvyl transferase
MID01_RS21730	COG1929	Belongs to the glycerate kinase type-1 family
MID01_RS21735	COG1802	Transcriptional regulator
MID01_RS21740	COG1070	Carbohydrate kinase
MID01_RS21745	COG2610	gluconate transmembrane transporter activity
MID01_RS21750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MID01_RS21755	COG0450	alkyl hydroperoxide reductase
MID01_RS21760	COG3634	alkyl hydroperoxide reductase activity
MID01_RS21780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MID01_RS21780	COG1263	PTS System
MID01_RS21785	COG2188	Transcriptional regulator
MID01_RS21800	COG1131	(ABC) transporter
MID01_RS21805	COG1994	Peptidase M50
MID01_RS21810	COG0535	radical SAM domain protein
MID01_RS21820	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MID01_RS21830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MID01_RS21845	COG1063	alcohol dehydrogenase
MID01_RS21865	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MID01_RS21870	COG0456	acetyltransferase
MID01_RS21875	COG0457	Tetratricopeptide repeat
MID01_RS21885	COG0010	Belongs to the arginase family
MID01_RS21890	COG0833	amino acid
MID01_RS21895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MID01_RS21900	COG3829	transcription factor binding
MID01_RS21915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MID01_RS21920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MID01_RS21925	COG4853	Protein conserved in bacteria
MID01_RS21930	COG4863	YycH protein
MID01_RS21935	COG5002	protein histidine kinase activity
MID01_RS21940	COG0745	RESPONSE REGULATOR receiver
MID01_RS21970	COG0346	lactoylglutathione lyase activity
MID01_RS21975	COG0305	Participates in initiation and elongation during chromosome replication
MID01_RS21990	COG3093	addiction module antidote protein HigA
MID01_RS21995	COG2807	transmembrane transport
MID01_RS22000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MID01_RS22005	COG0359	binds to the 23S rRNA
MID01_RS22010	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MID01_RS22015	COG4241	membrane
MID01_RS22025	COG5577	PFAM Coat F domain
MID01_RS22030	COG1733	regulation of RNA biosynthetic process
MID01_RS22035	COG1227	inorganic diphosphatase activity
MID01_RS22050	COG2271	Major facilitator Superfamily
MID01_RS22055	COG4978	Transcriptional regulator
MID01_RS22055	COG0789	Transcriptional regulator
MID01_RS22075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MID01_RS22080	COG1846	Transcriptional regulator
MID01_RS22085	COG2153	protein acetylation
MID01_RS22090	COG2364	Membrane
MID01_RS22095	COG0456	acetyltransferase
MID01_RS22100	COG2315	Protein conserved in bacteria
MID01_RS22105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MID01_RS22125	COG0789	Transcriptional regulator
MID01_RS22130	COG0697	spore germination
MID01_RS22135	COG1331	Highly conserved protein containing a thioredoxin domain
MID01_RS22140	COG1266	CAAX protease self-immunity
MID01_RS22150	COG0110	maltose O-acetyltransferase activity
MID01_RS22155	COG0346	lactoylglutathione lyase activity
MID01_RS22160	COG1609	Transcriptional regulator
MID01_RS22165	COG0708	Exodeoxyribonuclease III
MID01_RS22170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MID01_RS22175	COG0629	single-stranded DNA binding
MID01_RS22180	COG0360	Binds together with S18 to 16S ribosomal RNA
MID01_RS22185	COG0012	GTP binding
MID01_RS22190	COG0243	molybdopterin cofactor binding
MID01_RS22195	COG4481	Protein conserved in bacteria
MID01_RS22200	COG3949	Membrane
MID01_RS22210	COG1475	DNA binding
MID01_RS22215	COG1192	Involved in chromosome partitioning
MID01_RS22225	COG1475	DNA binding
MID01_RS22230	COG0357	Ribosomal RNA small subunit methyltransferase G
MID01_RS22235	COG0445	tRNA wobble uridine modification
MID01_RS22240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MID01_RS22245	COG1847	R3H domain protein
MID01_RS22250	COG0706	membrane insertase activity
MID01_RS22255	COG0594	ribonuclease P activity