locus-tag	class	description
F8M43_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F8M43_RS00010	COG0592	DNA-directed DNA polymerase activity
F8M43_RS00015	COG2501	S4 domain
F8M43_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F8M43_RS00030	COG0187	DNA topoisomerase II activity
F8M43_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8M43_RS00070	COG0516	GMP reductase activity
F8M43_RS00070	COG0517	IMP dehydrogenase activity
F8M43_RS00075	COG1686	Belongs to the peptidase S11 family
F8M43_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
F8M43_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
F8M43_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F8M43_RS00100	COG1428	Deoxynucleoside kinase
F8M43_RS00105	COG1428	Deoxynucleoside kinase
F8M43_RS00110	COG1388	LysM domain
F8M43_RS00110	COG3858	chitin binding
F8M43_RS00115	COG1335	isochorismatase
F8M43_RS00120	COG0590	tRNA wobble adenosine to inosine editing
F8M43_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F8M43_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F8M43_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F8M43_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
F8M43_RS00190	COG3853	Toxic anion resistance protein (TelA)
F8M43_RS00195	COG1982	Orn Lys Arg decarboxylase major
F8M43_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F8M43_RS00205	COG3870	Protein conserved in bacteria
F8M43_RS00210	COG1728	Protein conserved in bacteria
F8M43_RS00215	COG0470	DNA polymerase III
F8M43_RS00220	COG1774	PSP1 C-terminal conserved region
F8M43_RS00225	COG4467	Involved in initiation control of chromosome replication
F8M43_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F8M43_RS00235	COG2827	Endonuclease containing a URI domain
F8M43_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F8M43_RS00245	COG2002	toxin-antitoxin pair type II binding
F8M43_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M43_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M43_RS00255	COG0084	hydrolase, TatD family'
F8M43_RS00260	COG3583	domain protein
F8M43_RS00260	COG3584	3D domain protein
F8M43_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F8M43_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F8M43_RS00280	COG4466	Protein conserved in bacteria
F8M43_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F8M43_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F8M43_RS00300	COG0251	oxidation-reduction process
F8M43_RS00305	COG2088	sporulation resulting in formation of a cellular spore
F8M43_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F8M43_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F8M43_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F8M43_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
F8M43_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F8M43_RS00340	COG2002	toxin-antitoxin pair type II binding
F8M43_RS00345	COG2244	polysaccharide biosynthetic process
F8M43_RS00350	COG3956	TIGRFAM MazG family protein
F8M43_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F8M43_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F8M43_RS00375	COG1098	S1 RNA binding domain
F8M43_RS00390	COG2208	phosphoserine phosphatase activity
F8M43_RS00395	COG2304	oxidoreductase activity
F8M43_RS00400	COG0515	serine threonine protein kinase
F8M43_RS00405	COG0037	tRNA processing
F8M43_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F8M43_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8M43_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F8M43_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F8M43_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8M43_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F8M43_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F8M43_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
F8M43_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8M43_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F8M43_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F8M43_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F8M43_RS00470	COG1396	sequence-specific DNA binding
F8M43_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F8M43_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F8M43_RS00560	COG4463	regulation of RNA biosynthetic process
F8M43_RS00565	COG3880	PFAM UvrB UvrC protein
F8M43_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
F8M43_RS00575	COG0542	response to heat
F8M43_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F8M43_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
F8M43_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
F8M43_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F8M43_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F8M43_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F8M43_RS00610	COG1045	serine acetyltransferase
F8M43_RS00615	COG0215	cysteine-tRNA ligase activity
F8M43_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
F8M43_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M43_RS00630	COG3688	RNA-binding protein containing a PIN domain
F8M43_RS00635	COG1595	DNA-templated transcription, initiation
F8M43_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8M43_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
F8M43_RS00660	COG0081	regulation of translation
F8M43_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F8M43_RS00675	COG2813	Specifically methylates the guanine in position
F8M43_RS00680	COG0085	RNA polymerase activity
F8M43_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F8M43_RS00690	COG1358	cellular component organization or biogenesis
F8M43_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F8M43_RS00700	COG0049	tRNA binding
F8M43_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F8M43_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F8M43_RS00715	COG0596	Alpha beta hydrolase
F8M43_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F8M43_RS00730	COG0088	Forms part of the polypeptide exit tunnel
F8M43_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F8M43_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F8M43_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F8M43_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F8M43_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F8M43_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F8M43_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F8M43_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F8M43_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F8M43_RS00820	COG0200	Binds to the 23S rRNA
F8M43_RS00825	COG0201	protein transport
F8M43_RS00830	COG0563	adenylate kinase activity
F8M43_RS00835	COG0024	Methionine aminopeptidase
F8M43_RS00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
F8M43_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F8M43_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F8M43_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F8M43_RS00865	COG0202	RNA polymerase activity
F8M43_RS00870	COG0203	ribosomal protein L17
F8M43_RS00875	COG1122	ATPase activity
F8M43_RS00880	COG1122	ATPase activity
F8M43_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F8M43_RS00890	COG0101	tRNA pseudouridine synthase activity
F8M43_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F8M43_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F8M43_RS00905	COG2226	methyltransferase
F8M43_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS00920	COG0489	protein tyrosine kinase activity
F8M43_RS00930	COG2194	sulfuric ester hydrolase activity
F8M43_RS00935	COG0726	polysaccharide deacetylase
F8M43_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
F8M43_RS01025	COG0385	Bile acid
F8M43_RS01030	COG2819	hydrolase of the alpha beta superfamily
F8M43_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS01050	COG2207	Transcriptional regulator
F8M43_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS01055	COG3876	Protein conserved in bacteria
F8M43_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
F8M43_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8M43_RS01070	COG1263	PTS System
F8M43_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS01075	COG1737	Transcriptional regulator
F8M43_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
F8M43_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS01090	COG1683	Conserved Protein
F8M43_RS01120	COG1595	DNA-templated transcription, initiation
F8M43_RS01125	COG5662	AntiSigma factor
F8M43_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F8M43_RS01135	COG4856	YbbR-like protein
F8M43_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8M43_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F8M43_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F8M43_RS01160	COG2169	Transcriptional regulator
F8M43_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8M43_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8M43_RS01175	COG3002	Belongs to the UPF0753 family
F8M43_RS01180	COG0288	reversible hydration of carbon dioxide
F8M43_RS01190	COG5609	conserved protein (DUF2294)
F8M43_RS01195	COG0640	Transcriptional regulator
F8M43_RS01200	COG2814	Major facilitator Superfamily
F8M43_RS01215	COG1404	Belongs to the peptidase S8 family
F8M43_RS01235	COG1132	(ABC) transporter
F8M43_RS01240	COG0596	Alpha beta hydrolase
F8M43_RS01245	COG0745	RESPONSE REGULATOR receiver
F8M43_RS01250	COG0642	Histidine kinase
F8M43_RS01260	COG0515	serine threonine protein kinase
F8M43_RS01275	COG1113	amino acid transport
F8M43_RS01290	COG2602	Beta-lactamase
F8M43_RS01295	COG2124	cytochrome p450
F8M43_RS01305	COG0531	amino acid
F8M43_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
F8M43_RS01315	COG2271	Major facilitator Superfamily
F8M43_RS01330	COG0456	acetyltransferase
F8M43_RS01330	COG1846	Transcriptional regulator
F8M43_RS01335	COG2271	Major facilitator Superfamily
F8M43_RS01345	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS01350	COG0697	spore germination
F8M43_RS01355	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS01355	COG2207	Transcriptional regulator
F8M43_RS01360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
F8M43_RS01365	COG3591	Belongs to the peptidase S1B family
F8M43_RS01375	COG0596	Alpha beta hydrolase
F8M43_RS01380	COG1183	phosphatidylcholine synthase activity
F8M43_RS01385	COG0586	Pfam SNARE associated Golgi protein
F8M43_RS01390	COG0688	phosphatidylethanolamine metabolic process
F8M43_RS01400	COG1054	Belongs to the UPF0176 family
F8M43_RS01405	COG1301	dicarboxylic acid transport
F8M43_RS01410	COG2190	(PTS) system
F8M43_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS01410	COG1263	PTS System
F8M43_RS01415	COG0363	glucosamine-6-phosphate deaminase activity
F8M43_RS01420	COG2188	Transcriptional regulator
F8M43_RS01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8M43_RS01435	COG0833	amino acid
F8M43_RS01440	COG2040	homocysteine
F8M43_RS01450	COG1115	amino acid carrier protein
F8M43_RS01455	COG2066	Belongs to the glutaminase family
F8M43_RS01460	COG4191	Histidine kinase
F8M43_RS01465	COG0784	Response regulator, receiver
F8M43_RS01475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8M43_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS01485	COG2271	Major facilitator Superfamily
F8M43_RS01490	COG4948	Mandelate Racemase Muconate Lactonizing
F8M43_RS01495	COG2186	Transcriptional regulator
F8M43_RS01500	COG2721	sulfolactate sulfo-lyase activity
F8M43_RS01505	COG3173	Aminoglycoside phosphotransferase
F8M43_RS01515	COG0697	spore germination
F8M43_RS01520	COG0745	RESPONSE REGULATOR receiver
F8M43_RS01525	COG2205	protein histidine kinase activity
F8M43_RS01530	COG1131	(ABC) transporter
F8M43_RS01550	COG3773	Cell wall hydrolase
F8M43_RS01555	COG2304	oxidoreductase activity
F8M43_RS01565	COG3540	Alkaline phosphatase
F8M43_RS01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8M43_RS01575	COG0805	protein transport
F8M43_RS01580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
F8M43_RS01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8M43_RS01590	COG0477	Major facilitator Superfamily
F8M43_RS01595	COG1309	transcriptional regulator
F8M43_RS01600	COG0252	asparaginase activity
F8M43_RS01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F8M43_RS01610	COG1714	RDD family
F8M43_RS01615	COG3012	SEC-C Motif Domain Protein
F8M43_RS01615	COG1405	negative regulation of cell septum assembly
F8M43_RS01620	COG3290	protein histidine kinase activity
F8M43_RS01625	COG3279	Response regulator of the LytR AlgR family
F8M43_RS01630	COG4555	ABC transporter
F8M43_RS01635	COG1668	transmembrane transport
F8M43_RS01640	COG0667	Aldo Keto reductase
F8M43_RS01655	COG1595	DNA-templated transcription, initiation
F8M43_RS01660	COG1595	DNA-templated transcription, initiation
F8M43_RS01665	COG1876	peptidase activity
F8M43_RS01670	COG0457	Tetratricopeptide repeat
F8M43_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS01680	COG0366	Alpha amylase catalytic
F8M43_RS01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8M43_RS01690	COG1121	(ABC) transporter
F8M43_RS01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8M43_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS01705	COG2310	stress, protein
F8M43_RS01710	COG2310	stress, protein
F8M43_RS01715	COG2310	stress, protein
F8M43_RS01720	COG0861	Integral membrane protein TerC family
F8M43_RS01730	COG3853	Toxic anion resistance protein (TelA)
F8M43_RS01735	COG0477	Major facilitator Superfamily
F8M43_RS01745	COG2814	Major facilitator Superfamily
F8M43_RS01750	COG0640	Transcriptional regulator
F8M43_RS01755	COG4175	Glycine betaine
F8M43_RS01755	COG0517	IMP dehydrogenase activity
F8M43_RS01760	COG4176	ABC-type proline glycine betaine transport system permease component
F8M43_RS01765	COG2113	Glycine betaine
F8M43_RS01770	COG1473	amidohydrolase
F8M43_RS01775	COG1288	antiporter activity
F8M43_RS01785	COG0366	Alpha amylase catalytic
F8M43_RS01790	COG0039	L-malate dehydrogenase activity
F8M43_RS01795	COG1620	l-lactate permease
F8M43_RS01800	COG2814	Major facilitator Superfamily
F8M43_RS01805	COG1846	Transcriptional regulator
F8M43_RS01810	COG1280	lysine exporter protein (LysE YggA)
F8M43_RS01815	COG3403	YqcI/YcgG family
F8M43_RS01820	COG1113	amino acid transport
F8M43_RS01825	COG3665	Urea carboxylase-associated protein
F8M43_RS01830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F8M43_RS01835	COG1660	Displays ATPase and GTPase activities
F8M43_RS01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F8M43_RS01845	COG2226	methyltransferase
F8M43_RS01850	COG0583	DNA-binding transcription factor activity
F8M43_RS01855	COG3458	cephalosporin-C deacetylase activity
F8M43_RS01860	COG3541	Predicted nucleotidyltransferase
F8M43_RS01865	COG0506	proline dehydrogenase activity
F8M43_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M43_RS01880	COG2508	Transcriptional regulator
F8M43_RS01885	COG3689	TIGRFAM TIGR03943 family protein
F8M43_RS01890	COG0701	Predicted permease
F8M43_RS01895	COG2267	carboxylic ester hydrolase activity
F8M43_RS01900	COG0492	ferredoxin-NADP+ reductase activity
F8M43_RS01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8M43_RS01905	COG1587	Uroporphyrinogen-III synthase
F8M43_RS01910	COG2146	nitrite reductase [NAD(P)H] activity
F8M43_RS01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8M43_RS01920	COG0243	molybdopterin cofactor binding
F8M43_RS01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8M43_RS01930	COG2223	nitrite transmembrane transporter activity
F8M43_RS01935	COG1469	GTP cyclohydrolase I activity
F8M43_RS01940	COG1376	ErfK ybiS ycfS ynhG family protein
F8M43_RS01950	COG0523	cobalamin synthesis protein
F8M43_RS01955	COG0765	amino acid transport
F8M43_RS01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS01970	COG1714	RDD family
F8M43_RS01980	COG2723	6-phospho-beta-galactosidase activity
F8M43_RS01990	COG3209	COG3209 Rhs family protein
F8M43_RS01995	COG0840	transmembrane signaling receptor activity
F8M43_RS01995	COG3290	protein histidine kinase activity
F8M43_RS02000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F8M43_RS02005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
F8M43_RS02010	COG1733	regulation of RNA biosynthetic process
F8M43_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS02030	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
F8M43_RS02035	COG2814	Major facilitator Superfamily
F8M43_RS02045	COG0697	spore germination
F8M43_RS02060	COG2364	Membrane
F8M43_RS02065	COG1126	abc transporter atp-binding protein
F8M43_RS02070	COG0765	amino acid transport
F8M43_RS02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS02080	COG0583	DNA-binding transcription factor activity
F8M43_RS02085	COG0163	prenyltransferase activity
F8M43_RS02090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F8M43_RS02105	COG0596	Alpha beta hydrolase
F8M43_RS02110	COG3104	oligopeptide transport
F8M43_RS02115	COG5434	Belongs to the glycosyl hydrolase 28 family
F8M43_RS02125	COG0697	spore germination
F8M43_RS02135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8M43_RS02140	COG1136	(ABC) transporter
F8M43_RS02145	COG0577	efflux transmembrane transporter activity
F8M43_RS02150	COG0745	RESPONSE REGULATOR receiver
F8M43_RS02155	COG5002	protein histidine kinase activity
F8M43_RS02155	COG3850	Histidine kinase
F8M43_RS02160	COG0457	Tetratricopeptide repeat
F8M43_RS02180	COG0527	aspartate kinase activity
F8M43_RS02185	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS02190	COG4605	iron ion homeostasis
F8M43_RS02195	COG4604	ABC transporter, ATP-binding protein
F8M43_RS02200	COG4607	ABC-type enterochelin transport system periplasmic component
F8M43_RS02205	COG2814	Major facilitator Superfamily
F8M43_RS02210	COG1309	transcriptional regulator
F8M43_RS02215	COG0778	Nitroreductase
F8M43_RS02220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F8M43_RS02225	COG0640	Transcriptional regulator
F8M43_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS02235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
F8M43_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS02245	COG4975	Glucose uptake
F8M43_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS02255	COG4549	nuclear export factor GLE1
F8M43_RS02260	COG2372	response to copper ion
F8M43_RS02260	COG1276	copper resistance
F8M43_RS02265	COG1349	DNA-binding transcription factor activity
F8M43_RS02275	COG2213	PTS system mannitol-specific
F8M43_RS02280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS02285	COG0246	Mannitol dehydrogenase
F8M43_RS02290	COG0473	3-isopropylmalate dehydrogenase activity
F8M43_RS02295	COG0681	Belongs to the peptidase S26 family
F8M43_RS02300	COG0412	Dienelactone hydrolase
F8M43_RS02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8M43_RS02315	COG0561	phosphatase activity
F8M43_RS02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F8M43_RS02325	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M43_RS02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F8M43_RS02340	COG1984	allophanate hydrolase subunit 2
F8M43_RS02345	COG1414	Transcriptional regulator
F8M43_RS02350	COG2755	lipolytic protein G-D-S-L family
F8M43_RS02360	COG2329	Antibiotic biosynthesis monooxygenase
F8M43_RS02365	COG0768	penicillin binding
F8M43_RS02370	COG4989	oxidoreductase activity
F8M43_RS02375	COG3711	transcriptional antiterminator
F8M43_RS02380	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS02385	COG2226	methyltransferase
F8M43_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS02395	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS02400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS02405	COG3871	stress protein (general stress protein 26)
F8M43_RS02415	COG2814	Major facilitator Superfamily
F8M43_RS02420	COG1522	sequence-specific DNA binding
F8M43_RS02425	COG0551	DNA topoisomerase type I activity
F8M43_RS02425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M43_RS02430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
F8M43_RS02435	COG3706	GGDEF domain
F8M43_RS02440	COG5298	Protein conserved in bacteria
F8M43_RS02445	COG1215	transferase activity, transferring glycosyl groups
F8M43_RS02455	COG0531	amino acid
F8M43_RS02460	COG0494	nUDIX hydrolase
F8M43_RS02465	COG0028	Belongs to the TPP enzyme family
F8M43_RS02480	COG1914	H( )-stimulated, divalent metal cation uptake system
F8M43_RS02485	COG2261	transglycosylase associated protein
F8M43_RS02490	COG4876	unkown
F8M43_RS02495	COG2217	Heavy metal translocating P-type atpase
F8M43_RS02500	COG3729	General stress protein
F8M43_RS02505	COG0662	Cupin 2, conserved barrel domain protein
F8M43_RS02510	COG2329	Antibiotic biosynthesis monooxygenase
F8M43_RS02515	COG3546	catalase activity
F8M43_RS02520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F8M43_RS02525	COG3290	protein histidine kinase activity
F8M43_RS02530	COG4565	transcriptional regulatory protein
F8M43_RS02535	COG1301	dicarboxylic acid transport
F8M43_RS02540	COG0628	permease
F8M43_RS02545	COG1131	(ABC) transporter
F8M43_RS02550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F8M43_RS02560	COG1960	acyl-CoA dehydrogenase activity
F8M43_RS02575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F8M43_RS02580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS02585	COG1181	Belongs to the D-alanine--D-alanine ligase family
F8M43_RS02590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F8M43_RS02600	COG0513	Belongs to the DEAD box helicase family
F8M43_RS02605	COG3402	PFAM membrane-flanked domain
F8M43_RS02610	COG3428	Bacterial PH domain
F8M43_RS02615	COG0705	Rhomboid family
F8M43_RS02620	COG0736	holo-[acyl-carrier-protein] synthase activity
F8M43_RS02625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F8M43_RS02630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8M43_RS02635	COG0864	Transcriptional regulator
F8M43_RS02640	COG2337	Toxic component of a toxin-antitoxin (TA) module
F8M43_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS02655	COG2172	sigma factor antagonist activity
F8M43_RS02660	COG2208	phosphoserine phosphatase activity
F8M43_RS02665	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS02670	COG2172	sigma factor antagonist activity
F8M43_RS02675	COG1191	sigma factor activity
F8M43_RS02680	COG2208	phosphoserine phosphatase activity
F8M43_RS02685	COG2183	response to ionizing radiation
F8M43_RS02695	COG3091	SprT-like family
F8M43_RS02740	COG1476	TRANSCRIPTIONal
F8M43_RS02765	COG0693	protein deglycase activity
F8M43_RS02770	COG1278	Cold shock
F8M43_RS02775	COG1329	Transcriptional regulator
F8M43_RS02785	COG0697	spore germination
F8M43_RS02790	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS02790	COG2207	Transcriptional regulator
F8M43_RS02800	COG2207	Transcriptional regulator
F8M43_RS02800	COG3708	Transcriptional regulator
F8M43_RS02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS02810	COG0477	Major facilitator Superfamily
F8M43_RS02820	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
F8M43_RS02835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS02840	COG1309	transcriptional regulator
F8M43_RS02845	COG0697	spore germination
F8M43_RS02850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS02855	COG2030	dehydratase
F8M43_RS02860	COG3545	Serine hydrolase
F8M43_RS02865	COG1733	regulation of RNA biosynthetic process
F8M43_RS02870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS02875	COG2814	Major facilitator Superfamily
F8M43_RS02880	COG1309	transcriptional regulator
F8M43_RS02890	COG0640	Transcriptional regulator
F8M43_RS02895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F8M43_RS02905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS02910	COG0697	spore germination
F8M43_RS02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS02920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8M43_RS02925	COG0640	Transcriptional regulator
F8M43_RS02930	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8M43_RS02945	COG4585	Histidine kinase
F8M43_RS02950	COG2197	response regulator
F8M43_RS02955	COG2409	Drug exporters of the RND superfamily
F8M43_RS02960	COG0596	Alpha beta hydrolase
F8M43_RS02965	COG1811	Na channel or pump
F8M43_RS02970	COG0789	Transcriptional regulator
F8M43_RS02970	COG4978	Transcriptional regulator
F8M43_RS02975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F8M43_RS02980	COG0778	Nitroreductase
F8M43_RS02985	COG0346	lactoylglutathione lyase activity
F8M43_RS02990	COG2259	Doxx family
F8M43_RS02995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS03010	COG2323	membrane
F8M43_RS03015	COG2323	membrane
F8M43_RS03020	COG0071	Belongs to the small heat shock protein (HSP20) family
F8M43_RS03035	COG1309	transcriptional regulator
F8M43_RS03045	COG0456	acetyltransferase
F8M43_RS03050	COG0488	(ABC) transporter
F8M43_RS03055	COG1113	amino acid transport
F8M43_RS03060	COG2318	DinB family
F8M43_RS03065	COG1846	Transcriptional regulator
F8M43_RS03070	COG2409	Drug exporters of the RND superfamily
F8M43_RS03070	COG1033	growth of symbiont in host cell
F8M43_RS03075	COG0778	Nitroreductase
F8M43_RS03080	COG1846	Transcriptional regulator
F8M43_RS03085	COG2814	Major facilitator Superfamily
F8M43_RS03090	COG0730	response to heat
F8M43_RS03095	COG1802	Transcriptional regulator
F8M43_RS03100	COG1388	LysM domain
F8M43_RS03100	COG3858	chitin binding
F8M43_RS03105	COG1819	glycosyl
F8M43_RS03115	COG1785	Belongs to the alkaline phosphatase family
F8M43_RS03120	COG5646	InterPro IPR014922
F8M43_RS03130	COG0454	-acetyltransferase
F8M43_RS03135	COG1078	dGTPase activity
F8M43_RS03140	COG1388	LysM domain
F8M43_RS03145	COG2814	Major facilitator Superfamily
F8M43_RS03150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M43_RS03155	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M43_RS03160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M43_RS03165	COG2723	6-phospho-beta-galactosidase activity
F8M43_RS03170	COG2188	Transcriptional regulator
F8M43_RS03175	COG1940	carbohydrate kinase activity
F8M43_RS03180	COG1482	cell wall glycoprotein biosynthetic process
F8M43_RS03185	COG4124	Belongs to the glycosyl hydrolase 26 family
F8M43_RS03230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F8M43_RS03235	COG0802	atpase or kinase
F8M43_RS03240	COG1214	PFAM Peptidase M22, glycoprotease
F8M43_RS03245	COG0456	acetyltransferase
F8M43_RS03250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F8M43_RS03255	COG0488	(ABC) transporter
F8M43_RS03260	COG0315	cyclic pyranopterin monophosphate synthase activity
F8M43_RS03265	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F8M43_RS03270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8M43_RS03275	COG0805	protein transport
F8M43_RS03290	COG1266	CAAX protease self-immunity
F8M43_RS03300	COG0459	protein refolding
F8M43_RS03310	COG1073	alpha beta
F8M43_RS03315	COG0457	Tetratricopeptide repeat
F8M43_RS03320	COG1063	alcohol dehydrogenase
F8M43_RS03325	COG2211	Major facilitator Superfamily
F8M43_RS03330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M43_RS03335	COG1842	Phage shock protein A
F8M43_RS03340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F8M43_RS03345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F8M43_RS03350	COG4260	virion core protein, lumpy skin disease virus
F8M43_RS03365	COG2814	Major facilitator Superfamily
F8M43_RS03370	COG1063	alcohol dehydrogenase
F8M43_RS03375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F8M43_RS03380	COG0823	Involved in the tonB-independent uptake of proteins
F8M43_RS03395	COG2267	carboxylic ester hydrolase activity
F8M43_RS03405	COG2132	Multicopper oxidase
F8M43_RS03410	COG1113	amino acid transport
F8M43_RS03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F8M43_RS03425	COG0714	Associated with various cellular activities
F8M43_RS03430	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
F8M43_RS03435	COG1305	Transglutaminase-like
F8M43_RS03440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
F8M43_RS03440	COG0519	Catalyzes the synthesis of GMP from XMP
F8M43_RS03445	COG2252	PERMEase
F8M43_RS03450	COG3064	Membrane
F8M43_RS03460	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
F8M43_RS03470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F8M43_RS03475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F8M43_RS03480	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F8M43_RS03485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F8M43_RS03490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8M43_RS03495	COG0047	phosphoribosylformylglycinamidine synthase activity
F8M43_RS03500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F8M43_RS03505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F8M43_RS03510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F8M43_RS03515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F8M43_RS03520	COG0138	bifunctional purine biosynthesis protein purh
F8M43_RS03525	COG0151	Belongs to the GarS family
F8M43_RS03530	COG1522	sequence-specific DNA binding
F8M43_RS03535	COG0531	amino acid
F8M43_RS03545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8M43_RS03550	COG1470	cell adhesion involved in biofilm formation
F8M43_RS03555	COG4496	protein, YerC YecD
F8M43_RS03560	COG0069	glutamate synthase activity
F8M43_RS03565	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
F8M43_RS03570	COG0210	DNA helicase
F8M43_RS03575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F8M43_RS03580	COG4851	CamS sex pheromone cAM373 precursor
F8M43_RS03585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8M43_RS03590	COG1285	pathogenesis
F8M43_RS03595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M43_RS03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8M43_RS03605	COG0154	amidase activity
F8M43_RS03610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F8M43_RS03615	COG1309	transcriptional regulator
F8M43_RS03620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F8M43_RS03625	COG1597	lipid kinase activity
F8M43_RS03630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8M43_RS03640	COG0457	Tetratricopeptide repeat
F8M43_RS03655	COG5444	nuclease activity
F8M43_RS03660	COG3391	amine dehydrogenase activity
F8M43_RS03665	COG0457	Tetratricopeptide repeat
F8M43_RS03675	COG0217	transcriptional regulatory protein
F8M43_RS03685	COG1309	transcriptional regulator
F8M43_RS03690	COG3631	Ketosteroid isomerase-related protein
F8M43_RS03695	COG0702	epimerase
F8M43_RS03710	COG3546	catalase activity
F8M43_RS03715	COG0454	-acetyltransferase
F8M43_RS03725	COG5578	integral membrane protein
F8M43_RS03730	COG2972	Histidine kinase
F8M43_RS03735	COG2207	Transcriptional regulator
F8M43_RS03735	COG4753	response regulator
F8M43_RS03740	COG1653	transport
F8M43_RS03745	COG1175	transmembrane transport
F8M43_RS03750	COG0395	ABC-type sugar transport system, permease component
F8M43_RS03755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F8M43_RS03760	COG2207	Transcriptional regulator
F8M43_RS03765	COG2755	lipolytic protein G-D-S-L family
F8M43_RS03775	COG5578	integral membrane protein
F8M43_RS03780	COG3401	FG-GAP repeat protein
F8M43_RS03785	COG3401	FG-GAP repeat protein
F8M43_RS03790	COG2755	lipolytic protein G-D-S-L family
F8M43_RS03795	COG1874	Beta-galactosidase
F8M43_RS03805	COG1653	transport
F8M43_RS03810	COG4209	transmembrane transport
F8M43_RS03815	COG0395	ABC-type sugar transport system, permease component
F8M43_RS03820	COG1486	melibiose metabolic process
F8M43_RS03825	COG2323	membrane
F8M43_RS03830	COG2329	Antibiotic biosynthesis monooxygenase
F8M43_RS03835	COG0346	lactoylglutathione lyase activity
F8M43_RS03850	COG5583	Uncharacterized small protein (DUF2292)
F8M43_RS03855	COG0670	Belongs to the BI1 family
F8M43_RS03860	COG0697	spore germination
F8M43_RS03865	COG1846	Transcriptional regulator
F8M43_RS03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8M43_RS03885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F8M43_RS03885	COG2124	cytochrome p450
F8M43_RS03900	COG1368	sulfuric ester hydrolase activity
F8M43_RS03905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F8M43_RS03910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M43_RS03915	COG1442	glycosyl transferase family 8
F8M43_RS03920	COG1216	Glycosyl transferase, family 2
F8M43_RS03925	COG1442	glycosyl transferase family 8
F8M43_RS03930	COG2223	nitrite transmembrane transporter activity
F8M43_RS03935	COG1011	Hydrolase
F8M43_RS03940	COG0531	amino acid
F8M43_RS03945	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS03950	COG0840	transmembrane signaling receptor activity
F8M43_RS03955	COG0488	(ABC) transporter
F8M43_RS03965	COG0789	Transcriptional regulator
F8M43_RS03970	COG2814	Major facilitator Superfamily
F8M43_RS03975	COG0488	(ABC) transporter
F8M43_RS03980	COG0513	Belongs to the DEAD box helicase family
F8M43_RS03985	COG0456	acetyltransferase
F8M43_RS03990	COG2130	NADP-dependent
F8M43_RS04000	COG2211	Major facilitator Superfamily
F8M43_RS04005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
F8M43_RS04010	COG1120	ATPase activity
F8M43_RS04015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS04020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS04025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F8M43_RS04040	COG3866	Pectate lyase
F8M43_RS04045	COG0471	metal ion transport
F8M43_RS04050	COG3290	protein histidine kinase activity
F8M43_RS04055	COG4565	transcriptional regulatory protein
F8M43_RS04060	COG3181	Tripartite tricarboxylate transporter family receptor
F8M43_RS04065	COG2851	Citrate transporter
F8M43_RS04070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS04075	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
F8M43_RS04080	COG1254	Belongs to the acylphosphatase family
F8M43_RS04085	COG2258	MOSC domain
F8M43_RS04105	COG0024	Methionine aminopeptidase
F8M43_RS04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS04110	COG1263	PTS System
F8M43_RS04115	COG1368	sulfuric ester hydrolase activity
F8M43_RS04130	COG1115	amino acid carrier protein
F8M43_RS04135	COG0531	amino acid
F8M43_RS04150	COG0697	spore germination
F8M43_RS04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS04155	COG1263	PTS System
F8M43_RS04160	COG0366	Alpha amylase catalytic
F8M43_RS04165	COG2188	Transcriptional regulator
F8M43_RS04170	COG0778	Nitroreductase
F8M43_RS04175	COG0737	Belongs to the 5'-nucleotidase family
F8M43_RS04180	COG0693	protein deglycase activity
F8M43_RS04185	COG2814	Major facilitator Superfamily
F8M43_RS04190	COG4840	Belongs to the UPF0435 family
F8M43_RS04195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8M43_RS04200	COG4980	gas vesicle protein
F8M43_RS04205	COG1295	ribonuclease BN
F8M43_RS04210	COG0477	Major facilitator Superfamily
F8M43_RS04215	COG0387	Pfam Sodium calcium exchanger
F8M43_RS04225	COG0668	transmembrane transport
F8M43_RS04230	COG0535	radical SAM domain protein
F8M43_RS04240	COG0726	polysaccharide deacetylase
F8M43_RS04245	COG2084	Dehydrogenase
F8M43_RS04250	COG0598	Magnesium transport protein CorA
F8M43_RS04255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
F8M43_RS04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F8M43_RS04270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F8M43_RS04275	COG4637	Psort location Cytoplasmic, score
F8M43_RS04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F8M43_RS04285	COG0022	dehydrogenase e1 component
F8M43_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8M43_RS04295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8M43_RS04300	COG3284	Transcriptional regulator
F8M43_RS04310	COG1742	UPF0060 membrane protein
F8M43_RS04330	COG4842	Belongs to the WXG100 family
F8M43_RS04335	COG1486	melibiose metabolic process
F8M43_RS04340	COG1737	Transcriptional regulator
F8M43_RS04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS04345	COG1263	PTS System
F8M43_RS04350	COG5434	Belongs to the glycosyl hydrolase 28 family
F8M43_RS04355	COG1132	(ABC) transporter
F8M43_RS04360	COG1132	(ABC) transporter
F8M43_RS04365	COG2259	Doxx family
F8M43_RS04370	COG2514	catechol 2,3-dioxygenase activity
F8M43_RS04375	COG4585	Histidine kinase
F8M43_RS04380	COG2197	response regulator
F8M43_RS04385	COG1131	(ABC) transporter
F8M43_RS04390	COG1511	domain protein
F8M43_RS04390	COG0842	Transport permease protein
F8M43_RS04395	COG0842	Transport permease protein
F8M43_RS04400	COG1695	Transcriptional regulator
F8M43_RS04405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
F8M43_RS04410	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
F8M43_RS04415	COG2318	DinB family
F8M43_RS04420	COG2814	Major facilitator Superfamily
F8M43_RS04425	COG1846	Transcriptional regulator
F8M43_RS04430	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F8M43_RS04430	COG0392	lysyltransferase activity
F8M43_RS04435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS04450	COG0384	phenazine biosynthesis protein PhzF
F8M43_RS04455	COG0778	Nitroreductase
F8M43_RS04470	COG1090	epimerase
F8M43_RS04475	COG2137	regulation of response to DNA damage stimulus
F8M43_RS04485	COG2814	Major facilitator Superfamily
F8M43_RS04500	COG3103	Sh3 type 3 domain protein
F8M43_RS04505	COG5658	integral membrane protein
F8M43_RS04510	COG0596	Alpha beta hydrolase
F8M43_RS04515	COG0463	Glycosyl transferase, family 2
F8M43_RS04520	COG4485	Bacterial membrane protein, YfhO
F8M43_RS04525	COG1988	membrane-bound metal-dependent
F8M43_RS04530	COG1194	a g-specific adenine glycosylase
F8M43_RS04540	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS04555	COG3557	Belongs to the UPF0374 family
F8M43_RS04560	COG1132	(ABC) transporter
F8M43_RS04565	COG4129	membrane
F8M43_RS04570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8M43_RS04575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F8M43_RS04580	COG0735	belongs to the Fur family
F8M43_RS04690	COG4326	sporulation control protein
F8M43_RS04700	COG5577	PFAM Coat F domain
F8M43_RS04705	COG3340	Belongs to the peptidase S51 family
F8M43_RS04710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F8M43_RS04715	COG0277	FAD linked oxidase domain protein
F8M43_RS04725	COG0753	catalase activity
F8M43_RS04730	COG1116	anion transmembrane transporter activity
F8M43_RS04735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8M43_RS04740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M43_RS04745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS04755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F8M43_RS04765	COG1476	TRANSCRIPTIONal
F8M43_RS04775	COG3382	B3 4 domain protein
F8M43_RS04780	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F8M43_RS04790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F8M43_RS04795	COG0789	Transcriptional regulator
F8M43_RS04800	COG1664	Polymer-forming cytoskeletal
F8M43_RS04805	COG1664	Polymer-forming cytoskeletal
F8M43_RS04810	COG2766	serine protein kinase
F8M43_RS04815	COG2718	Belongs to the UPF0229 family
F8M43_RS04820	COG1846	Transcriptional regulator
F8M43_RS04825	COG1566	PFAM secretion protein HlyD family protein
F8M43_RS04830	COG2814	Major facilitator Superfamily
F8M43_RS04835	COG0655	NAD(P)H dehydrogenase (quinone) activity
F8M43_RS04855	COG1725	Transcriptional regulator
F8M43_RS04860	COG1131	(ABC) transporter
F8M43_RS04865	COG1131	(ABC) transporter
F8M43_RS04870	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F8M43_RS04875	COG1278	Cold shock
F8M43_RS04885	COG1464	Belongs to the NlpA lipoprotein family
F8M43_RS04890	COG3706	GGDEF domain
F8M43_RS04895	COG1823	symporter activity
F8M43_RS04915	COG5577	PFAM Coat F domain
F8M43_RS04920	COG0737	Belongs to the 5'-nucleotidase family
F8M43_RS04920	COG1525	nuclease
F8M43_RS04920	COG4085	toxin activity
F8M43_RS04925	COG3764	Sortase (surface protein transpeptidase)
F8M43_RS04930	COG0564	pseudouridine synthase activity
F8M43_RS04940	COG0517	IMP dehydrogenase activity
F8M43_RS04945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8M43_RS04950	COG3153	acetyltransferase
F8M43_RS04950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8M43_RS04960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8M43_RS04965	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
F8M43_RS04970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F8M43_RS04975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F8M43_RS04980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F8M43_RS04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F8M43_RS04990	COG4585	Histidine kinase
F8M43_RS04990	COG2203	Gaf domain
F8M43_RS04995	COG2197	response regulator
F8M43_RS05000	COG0431	NADPH-dependent FMN reductase
F8M43_RS05015	COG1388	LysM domain
F8M43_RS05015	COG0791	NLP P60 protein
F8M43_RS05020	COG1959	2 iron, 2 sulfur cluster binding
F8M43_RS05025	COG0668	transmembrane transport
F8M43_RS05030	COG2719	SpoVR family
F8M43_RS05035	COG1785	Belongs to the alkaline phosphatase family
F8M43_RS05040	COG0791	NLP P60 protein
F8M43_RS05040	COG1388	LysM domain
F8M43_RS05045	COG0583	DNA-binding transcription factor activity
F8M43_RS05050	COG0372	Belongs to the citrate synthase family
F8M43_RS05055	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS05060	COG0531	amino acid
F8M43_RS05065	COG0733	neurotransmitter:sodium symporter activity
F8M43_RS05070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS05090	COG1595	DNA-templated transcription, initiation
F8M43_RS05095	COG0667	Aldo Keto reductase
F8M43_RS05100	COG0204	Acyl-transferase
F8M43_RS05105	COG1253	flavin adenine dinucleotide binding
F8M43_RS05110	COG0789	Transcriptional regulator
F8M43_RS05115	COG0436	Aminotransferase
F8M43_RS05120	COG1253	flavin adenine dinucleotide binding
F8M43_RS05125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8M43_RS05130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F8M43_RS05135	COG0584	glycerophosphoryl diester phosphodiesterase
F8M43_RS05145	COG0668	transmembrane transport
F8M43_RS05150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F8M43_RS05155	COG0726	polysaccharide deacetylase
F8M43_RS05160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8M43_RS05165	COG1757	Na H antiporter
F8M43_RS05170	COG0589	response to stress
F8M43_RS05180	COG1132	(ABC) transporter
F8M43_RS05185	COG1132	(ABC) transporter
F8M43_RS05190	COG0702	epimerase
F8M43_RS05210	COG0189	ligase activity
F8M43_RS05215	COG0189	ligase activity
F8M43_RS05220	COG4399	Belongs to the UPF0754 family
F8M43_RS05225	COG3679	Belongs to the UPF0342 family
F8M43_RS05230	COG4335	DNA alkylation repair
F8M43_RS05235	COG0561	phosphatase activity
F8M43_RS05240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8M43_RS05245	COG0475	glutathione-regulated potassium exporter activity
F8M43_RS05250	COG0490	domain, Protein
F8M43_RS05260	COG1024	Enoyl-CoA hydratase
F8M43_RS05270	COG4152	abc transporter atp-binding protein
F8M43_RS05275	COG1668	transmembrane transport
F8M43_RS05280	COG0420	3'-5' exonuclease activity
F8M43_RS05285	COG4717	serine-type aminopeptidase activity
F8M43_RS05290	COG3481	metal-dependent phosphohydrolase, HD sub domain
F8M43_RS05300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F8M43_RS05330	COG1846	Transcriptional regulator
F8M43_RS05335	COG4980	gas vesicle protein
F8M43_RS05350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
F8M43_RS05355	COG0537	adenosine 5'-monophosphoramidase activity
F8M43_RS05360	COG1131	(ABC) transporter
F8M43_RS05365	COG4473	ABC transporter
F8M43_RS05375	COG1473	amidohydrolase
F8M43_RS05380	COG3069	C4-dicarboxylate transmembrane transporter activity
F8M43_RS05390	COG2329	Antibiotic biosynthesis monooxygenase
F8M43_RS05395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M43_RS05400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F8M43_RS05405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
F8M43_RS05410	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F8M43_RS05415	COG1309	transcriptional regulator
F8M43_RS05420	COG1511	domain protein
F8M43_RS05425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8M43_RS05430	COG4377	Putative membrane peptidase family (DUF2324)
F8M43_RS05440	COG1363	Peptidase, m42
F8M43_RS05445	COG4405	Protein conserved in bacteria
F8M43_RS05450	COG1301	dicarboxylic acid transport
F8M43_RS05460	COG1234	tRNA 3'-trailer cleavage
F8M43_RS05465	COG0095	Lipoate-protein ligase
F8M43_RS05470	COG0702	epimerase
F8M43_RS05475	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS05485	COG0501	Belongs to the peptidase M48B family
F8M43_RS05490	COG1404	Belongs to the peptidase S8 family
F8M43_RS05500	COG0604	alcohol dehydrogenase
F8M43_RS05505	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F8M43_RS05510	COG0406	alpha-ribazole phosphatase activity
F8M43_RS05515	COG0183	Belongs to the thiolase family
F8M43_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS05525	COG1268	BioY protein
F8M43_RS05530	COG0840	transmembrane signaling receptor activity
F8M43_RS05535	COG0723	plastoquinol--plastocyanin reductase activity
F8M43_RS05535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8M43_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS05550	COG4903	ComK protein
F8M43_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS05565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M43_RS05580	COG0398	Pfam SNARE associated Golgi protein
F8M43_RS05585	COG0681	Belongs to the peptidase S26 family
F8M43_RS05590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F8M43_RS05595	COG1846	Transcriptional regulator
F8M43_RS05600	COG0738	Major facilitator superfamily
F8M43_RS05605	COG0673	inositol 2-dehydrogenase activity
F8M43_RS05610	COG0561	phosphatase activity
F8M43_RS05615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M43_RS05620	COG1609	Transcriptional regulator
F8M43_RS05625	COG3180	Ammonia monooxygenase
F8M43_RS05630	COG0477	Major facilitator Superfamily
F8M43_RS05630	COG2814	Major facilitator Superfamily
F8M43_RS05635	COG4533	DNA binding
F8M43_RS05645	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
F8M43_RS05650	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
F8M43_RS05655	COG1074	ATP-dependent DNA helicase activity
F8M43_RS05660	COG0420	3'-5' exonuclease activity
F8M43_RS05665	COG0419	ATPase involved in DNA repair
F8M43_RS05670	COG1403	HNH endonuclease
F8M43_RS05710	COG5337	Spore coat protein CotH
F8M43_RS05715	COG0179	Fumarylacetoacetate (FAA) hydrolase
F8M43_RS05725	COG1404	Belongs to the peptidase S8 family
F8M43_RS05735	COG0367	asparagine synthase
F8M43_RS05740	COG2318	DinB family
F8M43_RS05745	COG1562	ergosterol biosynthetic process
F8M43_RS05750	COG0534	Mate efflux family protein
F8M43_RS05755	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS05755	COG2207	Transcriptional regulator
F8M43_RS05760	COG1609	Transcriptional regulator
F8M43_RS05765	COG0673	inositol 2-dehydrogenase activity
F8M43_RS05770	COG2318	DinB family
F8M43_RS05775	COG1279	arginine transmembrane transporter activity
F8M43_RS05780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F8M43_RS05785	COG1357	PFAM Pentapeptide repeats (8 copies)
F8M43_RS05790	COG2267	carboxylic ester hydrolase activity
F8M43_RS05795	COG0529	Catalyzes the synthesis of activated sulfate
F8M43_RS05800	COG2046	Belongs to the sulfate adenylyltransferase family
F8M43_RS05805	COG0175	sulfate reduction
F8M43_RS05810	COG2045	Belongs to the ComB family
F8M43_RS05815	COG1809	phosphosulfolactate synthase activity
F8M43_RS05820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS05825	COG4948	Mandelate Racemase Muconate Lactonizing
F8M43_RS05830	COG2814	Major facilitator Superfamily
F8M43_RS05835	COG0454	-acetyltransferase
F8M43_RS05840	COG2153	protein acetylation
F8M43_RS05845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
F8M43_RS05845	COG0646	methionine synthase
F8M43_RS05850	COG1666	GTP binding
F8M43_RS05855	COG2996	Protein conserved in bacteria
F8M43_RS05875	COG1695	Transcriptional regulator
F8M43_RS05890	COG3227	Zinc metalloprotease (Elastase)
F8M43_RS05895	COG1307	EDD domain protein, DegV family
F8M43_RS05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS05915	COG0561	phosphatase activity
F8M43_RS05920	COG1073	alpha beta
F8M43_RS05925	COG2151	metal-sulfur cluster biosynthetic enzyme
F8M43_RS05935	COG0277	FAD linked oxidase domain protein
F8M43_RS05940	COG2271	Major facilitator Superfamily
F8M43_RS05945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F8M43_RS05950	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F8M43_RS05960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8M43_RS05965	COG0505	Belongs to the CarA family
F8M43_RS05970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8M43_RS05975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F8M43_RS05990	COG2267	carboxylic ester hydrolase activity
F8M43_RS06000	COG1744	ABC transporter substrate-binding protein PnrA-like
F8M43_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8M43_RS06020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8M43_RS06025	COG5504	Zn-dependent protease
F8M43_RS06030	COG0444	Belongs to the ABC transporter superfamily
F8M43_RS06035	COG4608	Belongs to the ABC transporter superfamily
F8M43_RS06045	COG0601	transmembrane transport
F8M43_RS06050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M43_RS06060	COG0180	Tryptophanyl-tRNA synthetase
F8M43_RS06065	COG4166	transmembrane transport
F8M43_RS06070	COG0601	transmembrane transport
F8M43_RS06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M43_RS06080	COG0444	Belongs to the ABC transporter superfamily
F8M43_RS06085	COG4608	Belongs to the ABC transporter superfamily
F8M43_RS06090	COG2814	Major facilitator Superfamily
F8M43_RS06095	COG0456	acetyltransferase
F8M43_RS06100	COG1393	Belongs to the ArsC family
F8M43_RS06105	COG0861	Integral membrane protein TerC family
F8M43_RS06115	COG4862	establishment of competence for transformation
F8M43_RS06125	COG4469	Competence protein
F8M43_RS06130	COG1164	Oligoendopeptidase f
F8M43_RS06145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F8M43_RS06150	COG2346	COG2346, Truncated hemoglobins
F8M43_RS06155	COG0741	lytic transglycosylase activity
F8M43_RS06160	COG4116	CYTH
F8M43_RS06170	COG2357	RelA SpoT domain protein
F8M43_RS06175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8M43_RS06180	COG0564	pseudouridine synthase activity
F8M43_RS06185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F8M43_RS06190	COG0475	glutathione-regulated potassium exporter activity
F8M43_RS06190	COG0569	domain protein
F8M43_RS06195	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F8M43_RS06200	COG0352	thiamine-phosphate diphosphorylase activity
F8M43_RS06205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8M43_RS06210	COG2104	thiamine diphosphate biosynthetic process
F8M43_RS06215	COG2022	thiamine diphosphate biosynthetic process
F8M43_RS06220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F8M43_RS06225	COG0351	phosphomethylpyrimidine kinase
F8M43_RS06230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F8M43_RS06285	COG0210	DNA helicase
F8M43_RS06295	COG2153	protein acetylation
F8M43_RS06300	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F8M43_RS06305	COG2382	esterase
F8M43_RS06310	COG0626	cystathionine gamma-synthase activity
F8M43_RS06315	COG0626	cystathionine gamma-synthase activity
F8M43_RS06325	COG5505	Protein of unknown function (DUF819)
F8M43_RS06350	COG5444	nuclease activity
F8M43_RS06400	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
F8M43_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS06415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS06415	COG3711	transcriptional antiterminator
F8M43_RS06420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M43_RS06420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M43_RS06420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS06425	COG1482	cell wall glycoprotein biosynthetic process
F8M43_RS06435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS06445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F8M43_RS06465	COG0109	protoheme IX farnesyltransferase activity
F8M43_RS06475	COG0726	polysaccharide deacetylase
F8M43_RS06490	COG5504	Zn-dependent protease
F8M43_RS06495	COG2205	protein histidine kinase activity
F8M43_RS06505	COG3383	formate dehydrogenase (NAD+) activity
F8M43_RS06510	COG2427	Protein of unknown function (DUF1641)
F8M43_RS06520	COG1051	belongs to the nudix hydrolase family
F8M43_RS06530	COG2124	cytochrome p450
F8M43_RS06535	COG1819	glycosyl
F8M43_RS06545	COG1587	Uroporphyrinogen-III synthase
F8M43_RS06550	COG0390	transport system, permease component
F8M43_RS06555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M43_RS06560	COG0697	spore germination
F8M43_RS06565	COG4297	protein containing double-stranded beta helix domain
F8M43_RS06575	COG1252	NADH dehydrogenase
F8M43_RS06580	COG1904	glucuronate isomerase
F8M43_RS06585	COG2211	Major facilitator Superfamily
F8M43_RS06590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F8M43_RS06595	COG1063	alcohol dehydrogenase
F8M43_RS06600	COG1312	Catalyzes the dehydration of D-mannonate
F8M43_RS06605	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS06610	COG2271	Major facilitator Superfamily
F8M43_RS06615	COG1609	Transcriptional regulator
F8M43_RS06620	COG0246	Mannitol dehydrogenase
F8M43_RS06625	COG2721	sulfolactate sulfo-lyase activity
F8M43_RS06630	COG0730	response to heat
F8M43_RS06635	COG2318	DinB family
F8M43_RS06640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F8M43_RS06645	COG0457	Tetratricopeptide repeat
F8M43_RS06655	COG2350	Protein conserved in bacteria
F8M43_RS06660	COG5632	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS06660	COG1388	LysM domain
F8M43_RS06660	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS06670	COG4195	phage-related replication protein
F8M43_RS06675	COG3546	catalase activity
F8M43_RS06680	COG2856	Zn peptidase
F8M43_RS06685	COG1396	sequence-specific DNA binding
F8M43_RS06695	COG1522	sequence-specific DNA binding
F8M43_RS06700	COG1484	DNA-dependent DNA replication
F8M43_RS06720	COG1595	DNA-templated transcription, initiation
F8M43_RS06725	COG5484	DNA packaging
F8M43_RS06725	COG3728	DNA packaging
F8M43_RS06730	COG1783	phage Terminase large subunit
F8M43_RS06735	COG5518	Phage portal protein
F8M43_RS06740	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F8M43_RS06745	COG4653	Phage capsid family
F8M43_RS06795	COG3953	SLT domain
F8M43_RS06795	COG5412	phage tail tape measure protein
F8M43_RS06795	COG3953	SLT domain
F8M43_RS06795	COG5412	phage tail tape measure protein
F8M43_RS06800	COG1652	LysM domain
F8M43_RS06805	COG4193	domain, Protein
F8M43_RS06815	COG3628	GPW Gp25 family protein
F8M43_RS06820	COG3299	homolog of phage Mu protein gp47
F8M43_RS06825	COG3778	Protein conserved in bacteria
F8M43_RS06865	COG5632	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS06865	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS06885	COG0306	phosphate transporter
F8M43_RS06890	COG1392	Phosphate transport regulator
F8M43_RS06895	COG0531	amino acid
F8M43_RS06900	COG0346	lactoylglutathione lyase activity
F8M43_RS06905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8M43_RS06910	COG0463	Glycosyl transferase, family 2
F8M43_RS06915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M43_RS06920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M43_RS06925	COG2362	D-Aminopeptidase
F8M43_RS06930	COG0601	transmembrane transport
F8M43_RS06935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F8M43_RS06940	COG0444	Belongs to the ABC transporter superfamily
F8M43_RS06945	COG4166	transmembrane transport
F8M43_RS06950	COG1619	proteins homologs of microcin C7 resistance protein MccF
F8M43_RS06955	COG4948	Mandelate Racemase Muconate Lactonizing
F8M43_RS06960	COG0791	NLP P60 protein
F8M43_RS06965	COG4608	Belongs to the ABC transporter superfamily
F8M43_RS06970	COG2706	6-phosphogluconolactonase activity
F8M43_RS06975	COG1834	amidinotransferase
F8M43_RS06980	COG1607	acyl-coa hydrolase
F8M43_RS06985	COG1017	nitric oxide dioxygenase activity
F8M43_RS06985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F8M43_RS06995	COG2323	membrane
F8M43_RS07000	COG2318	DinB family
F8M43_RS07005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS07010	COG2076	Multidrug Resistance protein
F8M43_RS07015	COG2076	Multidrug Resistance protein
F8M43_RS07020	COG0788	formyltetrahydrofolate deformylase activity
F8M43_RS07025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8M43_RS07030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F8M43_RS07035	COG1764	response to oxidative stress
F8M43_RS07040	COG1846	Transcriptional regulator
F8M43_RS07045	COG1764	response to oxidative stress
F8M43_RS07055	COG0590	tRNA wobble adenosine to inosine editing
F8M43_RS07060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M43_RS07065	COG1404	Belongs to the peptidase S8 family
F8M43_RS07070	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS07075	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F8M43_RS07080	COG1122	ATPase activity
F8M43_RS07085	COG4721	ABC-type cobalt transport system, permease component
F8M43_RS07095	COG0745	RESPONSE REGULATOR receiver
F8M43_RS07100	COG5002	protein histidine kinase activity
F8M43_RS07100	COG3850	Histidine kinase
F8M43_RS07105	COG3212	peptidase
F8M43_RS07110	COG3212	peptidase
F8M43_RS07125	COG2239	Acts as a magnesium transporter
F8M43_RS07130	COG0789	Transcriptional regulator
F8M43_RS07145	COG1846	Transcriptional regulator
F8M43_RS07150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M43_RS07155	COG0726	polysaccharide deacetylase
F8M43_RS07160	COG1408	metallophosphoesterase
F8M43_RS07170	COG0463	Glycosyl transferase, family 2
F8M43_RS07175	COG1793	dna ligase
F8M43_RS07175	COG3285	dna ligase
F8M43_RS07180	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
F8M43_RS07185	COG3300	MHYT domain
F8M43_RS07185	COG5001	Diguanylate cyclase
F8M43_RS07190	COG0586	Pfam SNARE associated Golgi protein
F8M43_RS07195	COG0861	Integral membrane protein TerC family
F8M43_RS07200	COG1191	sigma factor activity
F8M43_RS07220	COG0501	Belongs to the peptidase M48B family
F8M43_RS07225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F8M43_RS07240	COG3594	Acyltransferase
F8M43_RS07245	COG5002	protein histidine kinase activity
F8M43_RS07250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F8M43_RS07260	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F8M43_RS07265	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
F8M43_RS07270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F8M43_RS07275	COG0436	Aminotransferase
F8M43_RS07280	COG1850	ribulose-bisphosphate carboxylase activity
F8M43_RS07285	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
F8M43_RS07290	COG0235	Class ii aldolase
F8M43_RS07295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
F8M43_RS07300	COG3339	Conserved Protein
F8M43_RS07315	COG3852	Histidine kinase
F8M43_RS07325	COG1846	Transcriptional regulator
F8M43_RS07330	COG1360	Flagellar Motor Protein
F8M43_RS07335	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F8M43_RS07340	COG0542	response to heat
F8M43_RS07345	COG3949	Membrane
F8M43_RS07350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F8M43_RS07355	COG0720	synthase
F8M43_RS07360	COG0602	queuosine metabolic process
F8M43_RS07365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F8M43_RS07370	COG1733	regulation of RNA biosynthetic process
F8M43_RS07375	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS07380	COG4641	Protein conserved in bacteria
F8M43_RS07380	COG1388	LysM domain
F8M43_RS07385	COG1388	LysM domain
F8M43_RS07390	COG3858	chitin binding
F8M43_RS07400	COG4873	Protein conserved in bacteria
F8M43_RS07415	COG3773	Cell wall hydrolase
F8M43_RS07420	COG2244	polysaccharide biosynthetic process
F8M43_RS07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS07430	COG2217	Heavy metal translocating P-type atpase
F8M43_RS07440	COG0006	proline dipeptidase activity
F8M43_RS07445	COG1609	Transcriptional regulator
F8M43_RS07450	COG3711	transcriptional antiterminator
F8M43_RS07455	COG2190	(PTS) system
F8M43_RS07455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS07455	COG1263	PTS System
F8M43_RS07460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS07465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F8M43_RS07475	COG1533	DNA photolyase activity
F8M43_RS07480	COG0456	acetyltransferase
F8M43_RS07485	COG0840	transmembrane signaling receptor activity
F8M43_RS07490	COG2084	Dehydrogenase
F8M43_RS07495	COG2340	Cysteine-rich secretory protein family
F8M43_RS07500	COG0768	penicillin binding
F8M43_RS07505	COG4191	Histidine kinase
F8M43_RS07510	COG0436	Aminotransferase
F8M43_RS07520	COG0784	Response regulator, receiver
F8M43_RS07520	COG0835	chemotaxis
F8M43_RS07530	COG2814	Major facilitator Superfamily
F8M43_RS07535	COG1376	ErfK ybiS ycfS ynhG family protein
F8M43_RS07540	COG1408	metallophosphoesterase
F8M43_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS07550	COG2200	EAL domain
F8M43_RS07555	COG4703	Protein of unknown function (DUF1797)
F8M43_RS07560	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
F8M43_RS07570	COG0517	IMP dehydrogenase activity
F8M43_RS07575	COG0583	DNA-binding transcription factor activity
F8M43_RS07580	COG0716	FMN binding
F8M43_RS07590	COG0716	FMN binding
F8M43_RS07595	COG2171	N-acyltransferase activity
F8M43_RS07600	COG1473	amidohydrolase
F8M43_RS07610	COG0668	transmembrane transport
F8M43_RS07615	COG0450	alkyl hydroperoxide reductase
F8M43_RS07620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS07635	COG0746	molybdenum cofactor guanylyltransferase activity
F8M43_RS07640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F8M43_RS07645	COG0303	'Molybdopterin
F8M43_RS07650	COG1763	Mo-molybdopterin cofactor biosynthetic process
F8M43_RS07655	COG0314	molybdopterin synthase activity
F8M43_RS07660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F8M43_RS07665	COG1132	(ABC) transporter
F8M43_RS07670	COG1132	(ABC) transporter
F8M43_RS07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M43_RS07685	COG1136	(ABC) transporter
F8M43_RS07690	COG0577	efflux transmembrane transporter activity
F8M43_RS07695	COG1349	DNA-binding transcription factor activity
F8M43_RS07700	COG1105	Belongs to the carbohydrate kinase PfkB family
F8M43_RS07705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M43_RS07705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS07705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F8M43_RS07710	COG0681	Belongs to the peptidase S26 family
F8M43_RS07720	COG0488	(ABC) transporter
F8M43_RS07725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8M43_RS07730	COG2309	aminopeptidase activity
F8M43_RS07740	COG1077	Cell shape determining protein MreB Mrl
F8M43_RS07745	COG2002	toxin-antitoxin pair type II binding
F8M43_RS07750	COG3852	Histidine kinase
F8M43_RS07755	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F8M43_RS07755	COG2105	PFAM AIG2 family protein
F8M43_RS07760	COG0569	domain protein
F8M43_RS07765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F8M43_RS07770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F8M43_RS07775	COG5503	Protein of unknown function (DUF1447)
F8M43_RS07780	COG0561	phosphatase activity
F8M43_RS07785	COG0242	peptide deformylase activity
F8M43_RS07795	COG0497	DNA recombination
F8M43_RS07800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F8M43_RS07805	COG0022	dehydrogenase e1 component
F8M43_RS07810	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8M43_RS07815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8M43_RS07820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS07830	COG1982	Orn Lys Arg decarboxylase major
F8M43_RS07835	COG4476	Belongs to the UPF0223 family
F8M43_RS07840	COG4493	Belongs to the UPF0637 family
F8M43_RS07850	COG0483	inositol monophosphate 1-phosphatase activity
F8M43_RS07860	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
F8M43_RS07880	COG1595	DNA-templated transcription, initiation
F8M43_RS07900	COG1217	gtp-binding protein TYPA
F8M43_RS07910	COG4896	Protein conserved in bacteria
F8M43_RS07920	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
F8M43_RS07925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F8M43_RS07930	COG2066	Belongs to the glutaminase family
F8M43_RS07935	COG4838	Belongs to the UPF0358 family
F8M43_RS07940	COG0772	Belongs to the SEDS family
F8M43_RS07945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F8M43_RS07950	COG1612	heme a metabolic process
F8M43_RS07955	COG0109	protoheme IX farnesyltransferase activity
F8M43_RS07960	COG2010	Cytochrome c
F8M43_RS07960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8M43_RS07965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8M43_RS07970	COG1845	cytochrome c oxidase, subunit III
F8M43_RS07975	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F8M43_RS07980	COG3336	cytochrome c oxidase
F8M43_RS07990	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F8M43_RS07995	COG2340	Cysteine-rich secretory protein family
F8M43_RS08015	COG4471	UPF0298 protein
F8M43_RS08020	COG0742	ribosomal rna small subunit methyltransferase
F8M43_RS08025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F8M43_RS08030	COG3314	Sporulation integral membrane protein YlbJ
F8M43_RS08035	COG1752	Esterase of the alpha-beta hydrolase superfamily
F8M43_RS08040	COG3480	Lon protease (S16) C-terminal proteolytic domain
F8M43_RS08045	COG1323	Belongs to the UPF0348 family
F8M43_RS08055	COG1399	metal-binding, possibly nucleic acid-binding protein
F8M43_RS08070	COG0454	-acetyltransferase
F8M43_RS08075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F8M43_RS08080	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
F8M43_RS08085	COG2001	Belongs to the MraZ family
F8M43_RS08090	COG0275	rRNA processing
F8M43_RS08095	COG4839	cell division protein FtsL
F8M43_RS08100	COG0768	penicillin binding
F8M43_RS08105	COG0768	penicillin binding
F8M43_RS08110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F8M43_RS08115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8M43_RS08120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8M43_RS08125	COG0772	Belongs to the SEDS family
F8M43_RS08130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M43_RS08135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F8M43_RS08140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F8M43_RS08145	COG3879	Bacterial protein of unknown function (DUF881)
F8M43_RS08150	COG3879	Bacterial protein of unknown function (DUF881)
F8M43_RS08155	COG3856	small basic protein
F8M43_RS08160	COG0849	cell division
F8M43_RS08165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F8M43_RS08170	COG1404	Belongs to the peptidase S8 family
F8M43_RS08170	COG4412	M6 family metalloprotease domain protein
F8M43_RS08180	COG1191	sigma factor activity
F8M43_RS08185	COG1191	sigma factor activity
F8M43_RS08190	COG1119	ATPase activity
F8M43_RS08195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M43_RS08200	COG1873	PFAM PRC-barrel domain
F8M43_RS08205	COG1496	oxidoreductase activity
F8M43_RS08210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F8M43_RS08215	COG1799	cell septum assembly
F8M43_RS08220	COG0762	integral membrane protein
F8M43_RS08225	COG2302	S4 RNA-binding domain
F8M43_RS08230	COG3599	regulation of cell shape
F8M43_RS08235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F8M43_RS08240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F8M43_RS08245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F8M43_RS08250	COG0564	pseudouridine synthase activity
F8M43_RS08255	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
F8M43_RS08260	COG2233	PERMEase
F8M43_RS08265	COG0540	Belongs to the ATCase OTCase family
F8M43_RS08270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8M43_RS08275	COG0505	Belongs to the CarA family
F8M43_RS08280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F8M43_RS08285	COG0543	2 iron, 2 sulfur cluster binding
F8M43_RS08290	COG0167	dihydroorotate dehydrogenase activity
F8M43_RS08295	COG0284	orotidine-5'-phosphate decarboxylase activity
F8M43_RS08300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F8M43_RS08305	COG0175	sulfate reduction
F8M43_RS08310	COG0306	phosphate transporter
F8M43_RS08315	COG2046	Belongs to the sulfate adenylyltransferase family
F8M43_RS08320	COG0529	Catalyzes the synthesis of activated sulfate
F8M43_RS08325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F8M43_RS08330	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
F8M43_RS08335	COG1648	precorrin-2 dehydrogenase activity
F8M43_RS08340	COG1293	RNA-binding protein homologous to eukaryotic snRNP
F8M43_RS08345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M43_RS08350	COG1561	YicC-like family, N-terminal region
F8M43_RS08360	COG0194	GDP metabolic process
F8M43_RS08365	COG1758	RNA polymerase activity
F8M43_RS08370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F8M43_RS08375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F8M43_RS08380	COG0242	peptide deformylase activity
F8M43_RS08385	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F8M43_RS08390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F8M43_RS08390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8M43_RS08395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F8M43_RS08400	COG0631	protein serine/threonine phosphatase activity
F8M43_RS08405	COG2815	serine threonine protein kinase
F8M43_RS08405	COG0515	serine threonine protein kinase
F8M43_RS08410	COG1162	GTPase activity
F8M43_RS08415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F8M43_RS08420	COG1564	THIamine pyrophosphokinase
F8M43_RS08430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F8M43_RS08435	COG1302	Protein conserved in bacteria
F8M43_RS08440	COG1461	Dihydroxyacetone kinase
F8M43_RS08445	COG1760	l-serine dehydratase
F8M43_RS08450	COG1760	l-serine dehydratase
F8M43_RS08455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F8M43_RS08460	COG1349	DNA-binding transcription factor activity
F8M43_RS08460	COG2050	protein possibly involved in aromatic compounds catabolism
F8M43_RS08465	COG0416	fatty acid biosynthetic process
F8M43_RS08470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F8M43_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS08485	COG0571	ribonuclease III activity
F8M43_RS08490	COG1196	nuclear chromosome segregation
F8M43_RS08495	COG0552	protein localization to endoplasmic reticulum
F8M43_RS08505	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
F8M43_RS08510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F8M43_RS08515	COG0228	four-way junction DNA binding
F8M43_RS08520	COG1837	Belongs to the UPF0109 family
F8M43_RS08530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F8M43_RS08535	COG0336	Belongs to the RNA methyltransferase TrmD family
F8M43_RS08540	COG0335	large ribosomal subunit rRNA binding
F8M43_RS08545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F8M43_RS08550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F8M43_RS08560	COG2257	FlhB HrpN YscU SpaS Family
F8M43_RS08565	COG0045	succinate-CoA ligase (ADP-forming) activity
F8M43_RS08570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F8M43_RS08575	COG0758	DNA mediated transformation
F8M43_RS08580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F8M43_RS08585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F8M43_RS08590	COG4974	Belongs to the 'phage' integrase family
F8M43_RS08595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F8M43_RS08600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F8M43_RS08605	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F8M43_RS08610	COG1815	bacterial-type flagellum-dependent cell motility
F8M43_RS08615	COG1558	bacterial-type flagellum-dependent cell motility
F8M43_RS08620	COG1677	Flagellar hook-basal body complex protein FliE
F8M43_RS08625	COG1766	The M ring may be actively involved in energy transduction
F8M43_RS08630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M43_RS08635	COG1317	bacterial-type flagellum organization
F8M43_RS08640	COG1157	protein secretion by the type III secretion system
F8M43_RS08645	COG2882	bacterial-type flagellum organization
F8M43_RS08650	COG3334	PFAM MgtE intracellular
F8M43_RS08655	COG3144	bacterial-type flagellum assembly
F8M43_RS08660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F8M43_RS08665	COG4786	Flagellar basal body rod
F8M43_RS08670	COG1582	Flagellar protein (FlbD)
F8M43_RS08675	COG1580	Controls the rotational direction of flagella during chemotaxis
F8M43_RS08680	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M43_RS08685	COG1776	CheC inhibitor of MCP methylation
F8M43_RS08685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F8M43_RS08690	COG2201	protein-glutamate methylesterase activity
F8M43_RS08695	COG3190	flagellar
F8M43_RS08700	COG1338	Plays a role in the flagellum-specific transport system
F8M43_RS08705	COG1987	bacterial-type flagellum assembly
F8M43_RS08710	COG1684	flagellar biosynthetic protein fliR
F8M43_RS08715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8M43_RS08720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F8M43_RS08725	COG1419	protein localization to endoplasmic reticulum
F8M43_RS08730	COG0455	bacterial-type flagellum organization
F8M43_RS08735	COG2201	protein-glutamate methylesterase activity
F8M43_RS08740	COG2198	Histidine kinase
F8M43_RS08740	COG0643	Histidine kinase
F8M43_RS08745	COG0835	chemotaxis
F8M43_RS08750	COG1776	CheC inhibitor of MCP methylation
F8M43_RS08755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F8M43_RS08760	COG1191	sigma factor activity
F8M43_RS08770	COG0052	Belongs to the universal ribosomal protein uS2 family
F8M43_RS08775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F8M43_RS08780	COG0528	UMP kinase activity
F8M43_RS08785	COG0233	cytoplasmic translational termination
F8M43_RS08790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F8M43_RS08795	COG4589	Belongs to the CDS family
F8M43_RS08800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F8M43_RS08805	COG0750	zinc metalloprotease
F8M43_RS08810	COG0442	prolyl-tRNA aminoacylation
F8M43_RS08815	COG2176	DNA-directed DNA polymerase activity
F8M43_RS08820	COG0779	Required for maturation of 30S ribosomal subunits
F8M43_RS08825	COG0195	Participates in both transcription termination and antitermination
F8M43_RS08830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
F8M43_RS08835	COG1358	cellular component organization or biogenesis
F8M43_RS08840	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F8M43_RS08845	COG1550	Protein conserved in bacteria
F8M43_RS08850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F8M43_RS08855	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F8M43_RS08860	COG0196	riboflavin kinase activity
F8M43_RS08865	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F8M43_RS08870	COG1185	polyribonucleotide nucleotidyltransferase activity
F8M43_RS08875	COG0726	polysaccharide deacetylase
F8M43_RS08880	COG0612	Peptidase, M16
F8M43_RS08885	COG1873	PFAM PRC-barrel domain
F8M43_RS08890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M43_RS08895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F8M43_RS08900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F8M43_RS08905	COG0527	aspartate kinase activity
F8M43_RS08910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F8M43_RS08915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
F8M43_RS08920	COG0740	serine-type endopeptidase activity
F8M43_RS08930	COG4980	gas vesicle protein
F8M43_RS08930	COG1674	ftsk spoiiie
F8M43_RS08935	COG2188	Transcriptional regulator
F8M43_RS08940	COG2814	Major facilitator Superfamily
F8M43_RS08945	COG0612	Peptidase, M16
F8M43_RS08950	COG0612	Peptidase, M16
F8M43_RS08955	COG0300	oxidoreductase activity
F8M43_RS08970	COG1426	Protein conserved in bacteria
F8M43_RS08975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F8M43_RS08980	COG1546	Belongs to the CinA family
F8M43_RS08980	COG1058	Belongs to the CinA family
F8M43_RS08985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F8M43_RS08990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8M43_RS08995	COG1418	mRNA catabolic process
F8M43_RS09000	COG1692	metallophosphoesterase
F8M43_RS09005	COG2359	stage V sporulation protein S
F8M43_RS09010	COG1063	alcohol dehydrogenase
F8M43_RS09015	COG0156	8-amino-7-oxononanoate synthase activity
F8M43_RS09020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8M43_RS09025	COG4550	Control of competence regulator ComK, YlbF/YmcA
F8M43_RS09035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F8M43_RS09040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F8M43_RS09055	COG3226	Transcriptional regulator
F8M43_RS09060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS09070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F8M43_RS09075	COG3321	synthase
F8M43_RS09080	COG2070	2-Nitropropane dioxygenase
F8M43_RS09080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F8M43_RS09085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M43_RS09090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F8M43_RS09095	COG3425	synthase
F8M43_RS09100	COG1024	Enoyl-CoA hydratase
F8M43_RS09105	COG1024	Enoyl-CoA hydratase
F8M43_RS09110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS09110	COG0300	oxidoreductase activity
F8M43_RS09110	COG3321	synthase
F8M43_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M43_RS09115	COG4221	oxidoreductase activity
F8M43_RS09115	COG3321	synthase
F8M43_RS09115	COG0300	oxidoreductase activity
F8M43_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS09120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M43_RS09120	COG3321	synthase
F8M43_RS09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M43_RS09125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS09125	COG3321	synthase
F8M43_RS09125	COG4221	oxidoreductase activity
F8M43_RS09130	COG3321	synthase
F8M43_RS09130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F8M43_RS09130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M43_RS09130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F8M43_RS09135	COG2124	cytochrome p450
F8M43_RS09145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS09150	COG1404	Belongs to the peptidase S8 family
F8M43_RS09160	COG4195	phage-related replication protein
F8M43_RS09165	COG1764	response to oxidative stress
F8M43_RS09170	COG2076	Multidrug Resistance protein
F8M43_RS09175	COG2076	Multidrug Resistance protein
F8M43_RS09190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F8M43_RS09195	COG1923	regulation of RNA biosynthetic process
F8M43_RS09210	COG1780	Probably involved in ribonucleotide reductase function
F8M43_RS09215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8M43_RS09220	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F8M43_RS09225	COG4112	unkown
F8M43_RS09230	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS09240	COG0464	growth
F8M43_RS09245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F8M43_RS09250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
F8M43_RS09255	COG0789	Transcriptional regulator
F8M43_RS09260	COG0174	glutamine synthetase
F8M43_RS09265	COG4974	Belongs to the 'phage' integrase family
F8M43_RS09285	COG3645	SOS response
F8M43_RS09285	COG3646	Phage regulatory protein
F8M43_RS09465	COG3953	SLT domain
F8M43_RS09465	COG5280	Phage tail tape measure protein TP901
F8M43_RS09475	COG1705	Flagellar rod assembly protein muramidase FlgJ
F8M43_RS09515	COG1388	LysM domain
F8M43_RS09515	COG5632	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS09515	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS09525	COG5444	nuclease activity
F8M43_RS09580	COG1598	PFAM Uncharacterised protein family UPF0150
F8M43_RS09670	COG0463	Glycosyl transferase, family 2
F8M43_RS09685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS09700	COG3655	Transcriptional regulator
F8M43_RS09715	COG0135	phosphoribosylanthranilate isomerase activity
F8M43_RS09735	COG2211	Major facilitator Superfamily
F8M43_RS09740	COG3507	Belongs to the glycosyl hydrolase 43 family
F8M43_RS09745	COG1940	carbohydrate kinase activity
F8M43_RS09750	COG2115	Belongs to the xylose isomerase family
F8M43_RS09755	COG1070	Carbohydrate kinase
F8M43_RS09765	COG1525	nuclease
F8M43_RS09770	COG2814	Major facilitator Superfamily
F8M43_RS09775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F8M43_RS09785	COG0756	dUTP diphosphatase activity
F8M43_RS09820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F8M43_RS09830	COG3832	glyoxalase III activity
F8M43_RS09875	COG4195	phage-related replication protein
F8M43_RS09885	COG0346	lactoylglutathione lyase activity
F8M43_RS09895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F8M43_RS09900	COG1388	LysM domain
F8M43_RS09905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F8M43_RS09910	COG4224	UPF0291 protein
F8M43_RS09915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F8M43_RS09925	COG3763	UPF0154 protein
F8M43_RS09935	COG0785	Cytochrome C biogenesis protein
F8M43_RS09940	COG2201	protein-glutamate methylesterase activity
F8M43_RS09945	COG4846	Membrane protein involved in cytochrome C biogenesis
F8M43_RS09955	COG0071	Belongs to the small heat shock protein (HSP20) family
F8M43_RS09970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F8M43_RS09975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS09995	COG0824	Thioesterase
F8M43_RS10005	COG4841	protein insertion into membrane
F8M43_RS10010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F8M43_RS10015	COG1832	CoA-binding protein
F8M43_RS10020	COG0187	DNA topoisomerase II activity
F8M43_RS10025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F8M43_RS10035	COG1115	amino acid carrier protein
F8M43_RS10050	COG5520	Belongs to the glycosyl hydrolase 30 family
F8M43_RS10055	COG3507	Belongs to the glycosyl hydrolase 43 family
F8M43_RS10065	COG2246	polysaccharide biosynthetic process
F8M43_RS10070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8M43_RS10075	COG0586	Pfam SNARE associated Golgi protein
F8M43_RS10080	COG2404	hydrolase activity, acting on ester bonds
F8M43_RS10085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8M43_RS10090	COG1024	Enoyl-CoA hydratase
F8M43_RS10095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8M43_RS10100	COG0511	ligase activity, forming carbon-carbon bonds
F8M43_RS10105	COG0439	Biotin carboxylase
F8M43_RS10110	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS10115	COG1960	acyl-CoA dehydrogenase activity
F8M43_RS10130	COG1649	PFAM Uncharacterised BCR, COG1649
F8M43_RS10140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS10140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F8M43_RS10145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS10155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS10160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS10165	COG2027	D-alanyl-D-alanine carboxypeptidase
F8M43_RS10170	COG2017	converts alpha-aldose to the beta-anomer
F8M43_RS10175	COG0534	Mate efflux family protein
F8M43_RS10190	COG0582	viral genome integration into host DNA
F8M43_RS10195	COG0166	Belongs to the GPI family
F8M43_RS10200	COG0405	Gamma-glutamyltransferase
F8M43_RS10205	COG0583	DNA-binding transcription factor activity
F8M43_RS10210	COG0604	alcohol dehydrogenase
F8M43_RS10215	COG0493	'glutamate synthase
F8M43_RS10220	COG0069	glutamate synthase activity
F8M43_RS10220	COG0070	glutamate synthase
F8M43_RS10220	COG0067	glutamate synthase
F8M43_RS10225	COG0583	DNA-binding transcription factor activity
F8M43_RS10230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F8M43_RS10235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M43_RS10245	COG0300	oxidoreductase activity
F8M43_RS10250	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F8M43_RS10260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F8M43_RS10275	COG2814	Major facilitator Superfamily
F8M43_RS10280	COG1070	Carbohydrate kinase
F8M43_RS10285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M43_RS10290	COG0243	molybdopterin cofactor binding
F8M43_RS10320	COG0840	transmembrane signaling receptor activity
F8M43_RS10320	COG5278	phosphoserine phosphatase activity
F8M43_RS10325	COG2368	4-hydroxyphenylacetate
F8M43_RS10330	COG4305	rare lipoprotein A
F8M43_RS10335	COG3619	membrane
F8M43_RS10340	COG3866	Pectate lyase
F8M43_RS10345	COG2135	peptidase activity
F8M43_RS10355	COG2140	Oxalate decarboxylase
F8M43_RS10365	COG0456	acetyltransferase
F8M43_RS10385	COG2720	vancomycin resistance protein
F8M43_RS10395	COG3655	Transcriptional regulator
F8M43_RS10400	COG3739	integral membrane protein
F8M43_RS10405	COG0583	DNA-binding transcription factor activity
F8M43_RS10410	COG0697	spore germination
F8M43_RS10420	COG0693	protein deglycase activity
F8M43_RS10425	COG2367	Beta-lactamase
F8M43_RS10450	COG3848	Pyruvate phosphate dikinase
F8M43_RS10450	COG0574	Belongs to the PEP-utilizing enzyme family
F8M43_RS10455	COG0726	polysaccharide deacetylase
F8M43_RS10465	COG2314	TM2 domain
F8M43_RS10470	COG1396	sequence-specific DNA binding
F8M43_RS10590	COG0457	Tetratricopeptide repeat
F8M43_RS10625	COG4282	regulation of fungal-type cell wall biogenesis
F8M43_RS10630	COG1231	oxidoreductase activity
F8M43_RS10635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M43_RS10640	COG2207	Transcriptional regulator
F8M43_RS10640	COG0662	Cupin 2, conserved barrel domain protein
F8M43_RS10645	COG0456	acetyltransferase
F8M43_RS10650	COG1309	transcriptional regulator
F8M43_RS10655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS10660	COG3708	Transcriptional regulator
F8M43_RS10665	COG2378	regulation of single-species biofilm formation
F8M43_RS10675	COG0640	Transcriptional regulator
F8M43_RS10680	COG0741	lytic transglycosylase activity
F8M43_RS10685	COG2322	membrane
F8M43_RS10700	COG1619	proteins homologs of microcin C7 resistance protein MccF
F8M43_RS10705	COG3239	Fatty acid desaturase
F8M43_RS10710	COG4585	Histidine kinase
F8M43_RS10715	COG2197	response regulator
F8M43_RS10720	COG3584	3D domain protein
F8M43_RS10720	COG1388	LysM domain
F8M43_RS10725	COG0514	ATP-dependent DNA helicase (RecQ)
F8M43_RS10740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F8M43_RS10745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F8M43_RS10760	COG0071	Belongs to the small heat shock protein (HSP20) family
F8M43_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS10790	COG1657	PFAM Prenyltransferase squalene oxidase
F8M43_RS10795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F8M43_RS10800	COG0733	neurotransmitter:sodium symporter activity
F8M43_RS10805	COG0385	Bile acid
F8M43_RS10810	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8M43_RS10815	COG0567	Dehydrogenase, E1 component
F8M43_RS10820	COG4548	von Willebrand factor, type A
F8M43_RS10825	COG0714	Associated with various cellular activities
F8M43_RS10830	COG2032	superoxide dismutase activity
F8M43_RS10835	COG0791	NLP P60 protein
F8M43_RS10835	COG1388	LysM domain
F8M43_RS10840	COG1819	glycosyl
F8M43_RS10845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F8M43_RS10850	COG0534	Mate efflux family protein
F8M43_RS10855	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS10860	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8M43_RS10865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8M43_RS10875	COG2962	Rard protein
F8M43_RS10890	COG2610	gluconate transmembrane transporter activity
F8M43_RS10895	COG1942	4-Oxalocrotonate Tautomerase
F8M43_RS10900	COG1733	regulation of RNA biosynthetic process
F8M43_RS10905	COG0778	Nitroreductase
F8M43_RS10910	COG0400	carboxylic ester hydrolase activity
F8M43_RS10915	COG0346	lactoylglutathione lyase activity
F8M43_RS10925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M43_RS10930	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS10930	COG0793	Belongs to the peptidase S41A family
F8M43_RS10935	COG2226	methyltransferase
F8M43_RS10945	COG1876	peptidase activity
F8M43_RS10950	COG0813	purine-nucleoside phosphorylase activity
F8M43_RS10965	COG0671	phosphoesterase, PA-phosphatase related
F8M43_RS10990	COG4479	Belongs to the UPF0346 family
F8M43_RS11000	COG1509	lysine 2,3-aminomutase activity
F8M43_RS11005	COG0456	acetyltransferase
F8M43_RS11010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M43_RS11015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8M43_RS11020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F8M43_RS11025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8M43_RS11040	COG0456	acetyltransferase
F8M43_RS11045	COG0463	Glycosyl transferase, family 2
F8M43_RS11060	COG4641	Protein conserved in bacteria
F8M43_RS11065	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
F8M43_RS11070	COG1086	Polysaccharide biosynthesis protein
F8M43_RS11075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M43_RS11080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F8M43_RS11085	COG1846	Transcriptional regulator
F8M43_RS11090	COG0534	Mate efflux family protein
F8M43_RS11100	COG4698	Protein conserved in bacteria
F8M43_RS11105	COG2755	lipolytic protein G-D-S-L family
F8M43_RS11110	COG1999	signal sequence binding
F8M43_RS11120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F8M43_RS11125	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M43_RS11130	COG1272	protein, Hemolysin III
F8M43_RS11135	COG0204	Acyl-transferase
F8M43_RS11140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8M43_RS11145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
F8M43_RS11150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F8M43_RS11160	COG2136	Putative SAM-dependent methyltransferase
F8M43_RS11160	COG2521	methyltransferase
F8M43_RS11170	COG0129	dihydroxy-acid dehydratase activity
F8M43_RS11175	COG1413	lyase activity
F8M43_RS11180	COG1418	mRNA catabolic process
F8M43_RS11185	COG0386	Belongs to the glutathione peroxidase family
F8M43_RS11190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
F8M43_RS11195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F8M43_RS11205	COG1278	Cold shock
F8M43_RS11225	COG0328	RNA-DNA hybrid ribonuclease activity
F8M43_RS11230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F8M43_RS11235	COG0328	RNA-DNA hybrid ribonuclease activity
F8M43_RS11245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8M43_RS11260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F8M43_RS11270	COG1755	Isoprenylcysteine carboxyl methyltransferase
F8M43_RS11275	COG3424	synthase
F8M43_RS11280	COG2233	PERMEase
F8M43_RS11285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F8M43_RS11290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
F8M43_RS11300	COG0800	Aldolase
F8M43_RS11305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M43_RS11310	COG1609	Transcriptional regulator
F8M43_RS11315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
F8M43_RS11320	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS11325	COG1199	ATP-dependent helicase activity
F8M43_RS11340	COG0116	Belongs to the methyltransferase superfamily
F8M43_RS11355	COG4474	Belongs to the UPF0398 family
F8M43_RS11370	COG3359	exonuclease
F8M43_RS11375	COG1111	helicase
F8M43_RS11375	COG1205	dead DEAH box helicase
F8M43_RS11380	COG2190	(PTS) system
F8M43_RS11385	COG0071	Belongs to the small heat shock protein (HSP20) family
F8M43_RS11420	COG3331	DNA recombination
F8M43_RS11425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M43_RS11425	COG4499	WXG100 protein secretion system (Wss), protein YukC
F8M43_RS11435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F8M43_RS11440	COG3935	DnaD domain protein
F8M43_RS11445	COG0017	Asparaginyl-tRNA synthetase
F8M43_RS11450	COG0436	Aminotransferase
F8M43_RS11455	COG5353	protein conserved in bacteria
F8M43_RS11465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F8M43_RS11465	COG1199	ATP-dependent helicase activity
F8M43_RS11470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F8M43_RS11475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F8M43_RS11480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F8M43_RS11485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F8M43_RS11485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F8M43_RS11490	COG0617	tRNA 3'-terminal CCA addition
F8M43_RS11495	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS11500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F8M43_RS11505	COG1803	Methylglyoxal synthase
F8M43_RS11510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F8M43_RS11515	COG1694	Mazg nucleotide pyrophosphohydrolase
F8M43_RS11520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS11530	COG4347	Protein of unknown function (DUF1405)
F8M43_RS11535	COG2010	Cytochrome c
F8M43_RS11535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F8M43_RS11540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F8M43_RS11545	COG0723	plastoquinol--plastocyanin reductase activity
F8M43_RS11555	COG5582	Belongs to the UPF0302 family
F8M43_RS11560	COG0457	Tetratricopeptide repeat
F8M43_RS11565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F8M43_RS11570	COG0287	Prephenate dehydrogenase
F8M43_RS11575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F8M43_RS11580	COG0159	tryptophan synthase activity
F8M43_RS11585	COG0133	tryptophan synthase activity
F8M43_RS11590	COG0135	phosphoribosylanthranilate isomerase activity
F8M43_RS11600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F8M43_RS11605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F8M43_RS11610	COG4401	Chorismate mutase type I
F8M43_RS11615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F8M43_RS11620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F8M43_RS11625	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F8M43_RS11630	COG0105	UTP biosynthetic process
F8M43_RS11635	COG0142	geranyltranstransferase activity
F8M43_RS11640	COG2226	methyltransferase
F8M43_RS11645	COG0142	geranyltranstransferase activity
F8M43_RS11655	COG0302	gtp cyclohydrolase
F8M43_RS11660	COG0776	regulation of translation
F8M43_RS11665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F8M43_RS11680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F8M43_RS11685	COG1160	GTP binding
F8M43_RS11710	COG1304	FMN binding
F8M43_RS11715	COG0539	negative regulation of cytoplasmic translation
F8M43_RS11720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F8M43_RS11730	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
F8M43_RS11735	COG2959	enzyme of heme biosynthesis
F8M43_RS11740	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS11740	COG3773	Cell wall hydrolase
F8M43_RS11745	COG2339	peptidase activity
F8M43_RS11750	COG0492	ferredoxin-NADP+ reductase activity
F8M43_RS11755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F8M43_RS11760	COG4862	establishment of competence for transformation
F8M43_RS11765	COG1408	metallophosphoesterase
F8M43_RS11775	COG1388	LysM domain
F8M43_RS11780	COG1266	CAAX protease self-immunity
F8M43_RS11785	COG0514	ATP-dependent DNA helicase (RecQ)
F8M43_RS11790	COG4955	Helix-turn-helix domain
F8M43_RS11795	COG1141	Ferredoxin
F8M43_RS11800	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
F8M43_RS11805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F8M43_RS11810	COG0710	3-dehydroquinate dehydratase activity
F8M43_RS11820	COG1595	DNA-templated transcription, initiation
F8M43_RS11825	COG5002	protein histidine kinase activity
F8M43_RS11830	COG0745	RESPONSE REGULATOR receiver
F8M43_RS11835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8M43_RS11840	COG1333	cytochrome c biogenesis protein
F8M43_RS11845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS11850	COG1187	pseudouridine synthase activity
F8M43_RS11855	COG0700	Nucleoside recognition
F8M43_RS11860	COG2715	membrane protein required for spore maturation
F8M43_RS11865	COG1686	Belongs to the peptidase S11 family
F8M43_RS11875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F8M43_RS11880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F8M43_RS11885	COG1547	Domain of unknown function (DUF309)
F8M43_RS11890	COG0456	acetyltransferase
F8M43_RS11895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F8M43_RS11900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8M43_RS11900	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F8M43_RS11905	COG0307	riboflavin synthase, alpha
F8M43_RS11910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8M43_RS11910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F8M43_RS11920	COG0681	Belongs to the peptidase S26 family
F8M43_RS11930	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
F8M43_RS11950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
F8M43_RS11960	COG4086	secreted protein
F8M43_RS11965	COG0019	diaminopimelate decarboxylase activity
F8M43_RS11970	COG0697	spore germination
F8M43_RS11985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F8M43_RS12005	COG1191	sigma factor activity
F8M43_RS12010	COG2172	sigma factor antagonist activity
F8M43_RS12015	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS12020	COG1686	Belongs to the peptidase S11 family
F8M43_RS12025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F8M43_RS12030	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
F8M43_RS12035	COG4974	Belongs to the 'phage' integrase family
F8M43_RS12045	COG0735	belongs to the Fur family
F8M43_RS12050	COG1300	Membrane
F8M43_RS12060	COG0281	malic enzyme
F8M43_RS12065	COG1757	Na H antiporter
F8M43_RS12070	COG1027	Aspartate ammonia-lyase
F8M43_RS12075	COG0252	asparaginase activity
F8M43_RS12080	COG1396	sequence-specific DNA binding
F8M43_RS12085	COG1379	DNA repair
F8M43_RS12090	COG0494	nUDIX hydrolase
F8M43_RS12100	COG0667	Aldo Keto reductase
F8M43_RS12110	COG1073	alpha beta
F8M43_RS12120	COG4918	Iron-sulphur cluster biosynthesis
F8M43_RS12125	COG0456	acetyltransferase
F8M43_RS12125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
F8M43_RS12130	COG2329	Antibiotic biosynthesis monooxygenase
F8M43_RS12135	COG0456	acetyltransferase
F8M43_RS12145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8M43_RS12155	COG2211	Major facilitator Superfamily
F8M43_RS12160	COG0346	lactoylglutathione lyase activity
F8M43_RS12165	COG1072	(Pantothenic acid kinase))
F8M43_RS12170	COG3048	D-serine ammonia-lyase activity
F8M43_RS12175	COG0300	oxidoreductase activity
F8M43_RS12180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS12185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M43_RS12190	COG4187	Peptidase family M20/M25/M40
F8M43_RS12195	COG1902	pentaerythritol trinitrate reductase activity
F8M43_RS12200	COG0596	Alpha beta hydrolase
F8M43_RS12210	COG1234	tRNA 3'-trailer cleavage
F8M43_RS12215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F8M43_RS12220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8M43_RS12225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F8M43_RS12235	COG0706	membrane insertase activity
F8M43_RS12240	COG3361	conserved protein (COG2071)
F8M43_RS12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8M43_RS12250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F8M43_RS12255	COG0346	lactoylglutathione lyase activity
F8M43_RS12265	COG1376	ErfK ybiS ycfS ynhG family protein
F8M43_RS12270	COG4129	membrane
F8M43_RS12275	COG1126	abc transporter atp-binding protein
F8M43_RS12280	COG0765	amino acid transport
F8M43_RS12285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS12295	COG1597	lipid kinase activity
F8M43_RS12300	COG2814	Major facilitator Superfamily
F8M43_RS12305	COG0789	Transcriptional regulator
F8M43_RS12305	COG4978	Transcriptional regulator
F8M43_RS12310	COG0508	dehydrogenase complex catalyzes the overall conversion of
F8M43_RS12315	COG0022	dehydrogenase e1 component
F8M43_RS12320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F8M43_RS12325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F8M43_RS12330	COG3426	butyrate kinase activity
F8M43_RS12335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F8M43_RS12340	COG0280	phosphate acetyltransferase
F8M43_RS12345	COG3290	protein histidine kinase activity
F8M43_RS12345	COG3829	transcription factor binding
F8M43_RS12355	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F8M43_RS12360	COG2079	MmgE PrpD family protein
F8M43_RS12365	COG0372	Belongs to the citrate synthase family
F8M43_RS12370	COG1960	acyl-CoA dehydrogenase activity
F8M43_RS12375	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8M43_RS12380	COG0183	Belongs to the thiolase family
F8M43_RS12385	COG0584	glycerophosphoryl diester phosphodiesterase
F8M43_RS12390	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS12405	COG1902	pentaerythritol trinitrate reductase activity
F8M43_RS12410	COG0745	RESPONSE REGULATOR receiver
F8M43_RS12415	COG0750	zinc metalloprotease
F8M43_RS12420	COG0497	DNA recombination
F8M43_RS12425	COG1438	arginine binding
F8M43_RS12430	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F8M43_RS12435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M43_RS12440	COG0142	geranyltranstransferase activity
F8M43_RS12445	COG1722	exodeoxyribonuclease VII activity
F8M43_RS12450	COG1570	exodeoxyribonuclease VII activity
F8M43_RS12455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F8M43_RS12460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F8M43_RS12465	COG1302	Protein conserved in bacteria
F8M43_RS12470	COG0439	Biotin carboxylase
F8M43_RS12475	COG0511	ligase activity, forming carbon-carbon bonds
F8M43_RS12515	COG3854	ATPases associated with a variety of cellular activities
F8M43_RS12525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F8M43_RS12530	COG0006	proline dipeptidase activity
F8M43_RS12535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F8M43_RS12545	COG3872	metal-dependent enzyme
F8M43_RS12555	COG1752	Esterase of the alpha-beta hydrolase superfamily
F8M43_RS12560	COG1321	iron dependent repressor
F8M43_RS12565	COG0095	Lipoate-protein ligase
F8M43_RS12570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M43_RS12575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8M43_RS12580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F8M43_RS12585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F8M43_RS12590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8M43_RS12605	COG1396	sequence-specific DNA binding
F8M43_RS12615	COG0681	Belongs to the peptidase S26 family
F8M43_RS12640	COG4940	Competence protein ComGF
F8M43_RS12650	COG4970	Tfp pilus assembly protein FimT
F8M43_RS12655	COG4537	Required for transformation and DNA binding
F8M43_RS12660	COG1459	type II secretion system
F8M43_RS12665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F8M43_RS12670	COG0517	IMP dehydrogenase activity
F8M43_RS12675	COG0598	Magnesium transport protein CorA
F8M43_RS12680	COG1253	flavin adenine dinucleotide binding
F8M43_RS12685	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS12695	COG1393	Belongs to the ArsC family
F8M43_RS12705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS12715	COG0011	TIGRFAM Protein of
F8M43_RS12725	COG2866	Carboxypeptidase
F8M43_RS12730	COG1368	sulfuric ester hydrolase activity
F8M43_RS12735	COG1940	carbohydrate kinase activity
F8M43_RS12740	COG4483	Protein conserved in bacteria
F8M43_RS12745	COG0705	Rhomboid family
F8M43_RS12745	COG0457	Tetratricopeptide repeat
F8M43_RS12755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F8M43_RS12765	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS12780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F8M43_RS12785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M43_RS12790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F8M43_RS12795	COG0581	inorganic phosphate transmembrane transporter activity
F8M43_RS12800	COG0573	inorganic phosphate transmembrane transporter activity
F8M43_RS12805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F8M43_RS12810	COG0768	penicillin binding
F8M43_RS12815	COG0477	Major facilitator Superfamily
F8M43_RS12820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F8M43_RS12825	COG2839	Protein conserved in bacteria
F8M43_RS12830	COG5521	maltodextrose utilization protein MalA
F8M43_RS12835	COG1388	LysM domain
F8M43_RS12840	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F8M43_RS12845	COG4709	membrane
F8M43_RS12850	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
F8M43_RS12855	COG0735	belongs to the Fur family
F8M43_RS12860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS12870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
F8M43_RS12875	COG0513	Belongs to the DEAD box helicase family
F8M43_RS12885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F8M43_RS12890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F8M43_RS12895	COG2384	SAM-dependent methyltransferase
F8M43_RS12900	COG2010	Cytochrome c
F8M43_RS12910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F8M43_RS12915	COG0358	DNA primase activity
F8M43_RS12920	COG1671	Belongs to the UPF0178 family
F8M43_RS12925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F8M43_RS12930	COG0517	IMP dehydrogenase activity
F8M43_RS12935	COG0751	glycine-tRNA ligase activity
F8M43_RS12940	COG0752	glycyl-tRNA synthetase alpha subunit
F8M43_RS12945	COG1381	Involved in DNA repair and RecF pathway recombination
F8M43_RS12955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F8M43_RS12960	COG0295	cytidine deaminase activity
F8M43_RS12965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F8M43_RS12970	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F8M43_RS12975	COG1480	7TM receptor with intracellular HD hydrolase
F8M43_RS12980	COG1702	phosphate starvation-inducible protein PhoH
F8M43_RS12985	COG0561	phosphatase activity
F8M43_RS13000	COG4864	UPF0365 protein
F8M43_RS13005	COG1030	water channel activity
F8M43_RS13010	COG1610	YqeY-like protein
F8M43_RS13020	COG1283	sodium-dependent phosphate transmembrane transporter activity
F8M43_RS13025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F8M43_RS13030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F8M43_RS13035	COG2264	protein methyltransferase activity
F8M43_RS13040	COG0484	heat shock protein binding
F8M43_RS13045	COG0443	Heat shock 70 kDa protein
F8M43_RS13050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F8M43_RS13055	COG1420	regulation of RNA biosynthetic process
F8M43_RS13060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F8M43_RS13065	COG0481	GTPase activity
F8M43_RS13075	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS13080	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F8M43_RS13085	COG0268	Binds directly to 16S ribosomal RNA
F8M43_RS13090	COG1466	dna polymerase III delta subunit
F8M43_RS13105	COG0658	competence protein
F8M43_RS13105	COG2333	competence protein COMEC
F8M43_RS13110	COG2131	deaminase
F8M43_RS13115	COG1596	polysaccharide export
F8M43_RS13115	COG1555	photosystem II stabilization
F8M43_RS13120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F8M43_RS13125	COG2226	methyltransferase
F8M43_RS13130	COG0799	negative regulation of ribosome biogenesis
F8M43_RS13135	COG1713	HD superfamily hydrolase involved in NAD metabolism
F8M43_RS13140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F8M43_RS13145	COG1534	Rna-binding protein
F8M43_RS13150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F8M43_RS13155	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
F8M43_RS13160	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
F8M43_RS13170	COG2755	lipolytic protein G-D-S-L family
F8M43_RS13175	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS13175	COG5632	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS13180	COG0398	Pfam SNARE associated Golgi protein
F8M43_RS13195	COG3209	COG3209 Rhs family protein
F8M43_RS13205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F8M43_RS13215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8M43_RS13220	COG0798	PFAM Bile acid sodium symporter
F8M43_RS13225	COG0346	lactoylglutathione lyase activity
F8M43_RS13230	COG0640	Transcriptional regulator
F8M43_RS13235	COG3403	YqcI/YcgG family
F8M43_RS13255	COG0604	alcohol dehydrogenase
F8M43_RS13280	COG0457	Tetratricopeptide repeat
F8M43_RS13295	COG5444	nuclease activity
F8M43_RS13320	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS13320	COG5632	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS13325	COG4824	toxin secretion phage lysis holin
F8M43_RS13355	COG3778	Protein conserved in bacteria
F8M43_RS13360	COG3299	homolog of phage Mu protein gp47
F8M43_RS13365	COG3628	GPW Gp25 family protein
F8M43_RS13375	COG4193	domain, Protein
F8M43_RS13380	COG1652	LysM domain
F8M43_RS13385	COG3953	SLT domain
F8M43_RS13385	COG5280	Phage tail tape measure protein TP901
F8M43_RS13445	COG4653	Phage capsid family
F8M43_RS13450	COG0338	D12 class N6 adenine-specific DNA methyltransferase
F8M43_RS13460	COG2369	cell adhesion
F8M43_RS13465	COG5518	Phage portal protein
F8M43_RS13470	COG1783	phage Terminase large subunit
F8M43_RS13475	COG5484	DNA packaging
F8M43_RS13490	COG3677	Transposase
F8M43_RS13510	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
F8M43_RS13520	COG1484	DNA-dependent DNA replication
F8M43_RS13525	COG3935	DnaD domain protein
F8M43_RS13530	COG3723	Recombinational DNA repair protein, rece pathway
F8M43_RS13535	COG5377	YqaJ viral recombinase family
F8M43_RS13570	COG3620	sequence-specific DNA binding
F8M43_RS13580	COG0563	adenylate kinase activity
F8M43_RS13585	COG2856	Zn peptidase
F8M43_RS13595	COG5002	protein histidine kinase activity
F8M43_RS13595	COG0642	Histidine kinase
F8M43_RS13600	COG0745	RESPONSE REGULATOR receiver
F8M43_RS13605	COG2311	Membrane
F8M43_RS13615	COG0454	-acetyltransferase
F8M43_RS13620	COG2249	NAD(P)H dehydrogenase (quinone) activity
F8M43_RS13630	COG0730	response to heat
F8M43_RS13635	COG0425	Belongs to the sulfur carrier protein TusA family
F8M43_RS13640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS13640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M43_RS13650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M43_RS13650	COG0425	Belongs to the sulfur carrier protein TusA family
F8M43_RS13660	COG1937	Protein conserved in bacteria
F8M43_RS13675	COG0662	Cupin 2, conserved barrel domain protein
F8M43_RS13690	COG0789	Transcriptional regulator
F8M43_RS13690	COG4978	Transcriptional regulator
F8M43_RS13695	COG2814	Major facilitator Superfamily
F8M43_RS13700	COG0456	acetyltransferase
F8M43_RS13705	COG1253	flavin adenine dinucleotide binding
F8M43_RS13715	COG0697	spore germination
F8M43_RS13720	COG0583	DNA-binding transcription factor activity
F8M43_RS13725	COG2072	flavoprotein involved in K transport
F8M43_RS13730	COG1230	cation diffusion facilitator family transporter
F8M43_RS13735	COG1942	4-Oxalocrotonate Tautomerase
F8M43_RS13740	COG0583	DNA-binding transcription factor activity
F8M43_RS13750	COG1114	Component of the transport system for branched-chain amino acids
F8M43_RS13755	COG1687	branched-chain amino acid
F8M43_RS13760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F8M43_RS13765	COG1522	sequence-specific DNA binding
F8M43_RS13775	COG2124	cytochrome p450
F8M43_RS13785	COG1335	isochorismatase
F8M43_RS13800	COG2318	DinB family
F8M43_RS13810	COG2070	2-Nitropropane dioxygenase
F8M43_RS13825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8M43_RS13835	COG2186	Transcriptional regulator
F8M43_RS13850	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS13855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F8M43_RS13860	COG3959	Transketolase, thiamine diphosphate binding domain
F8M43_RS13875	COG0789	Transcriptional regulator
F8M43_RS13875	COG4978	Transcriptional regulator
F8M43_RS13880	COG2315	Protein conserved in bacteria
F8M43_RS13890	COG3443	Belongs to the bacterial solute-binding protein 9 family
F8M43_RS13895	COG1595	DNA-templated transcription, initiation
F8M43_RS13900	COG0667	Aldo Keto reductase
F8M43_RS13905	COG2851	Citrate transporter
F8M43_RS13910	COG0583	DNA-binding transcription factor activity
F8M43_RS13915	COG2828	Protein conserved in bacteria
F8M43_RS13920	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS13925	COG5566	PFAM Mor transcription activator
F8M43_RS13930	COG0596	Alpha beta hydrolase
F8M43_RS13935	COG4991	sh3 domain protein
F8M43_RS13940	COG4991	sh3 domain protein
F8M43_RS13950	COG0346	lactoylglutathione lyase activity
F8M43_RS13960	COG5577	PFAM Coat F domain
F8M43_RS13965	COG1063	alcohol dehydrogenase
F8M43_RS13975	COG5577	PFAM Coat F domain
F8M43_RS13980	COG0789	Transcriptional regulator
F8M43_RS13990	COG1064	alcohol dehydrogenase
F8M43_RS13995	COG0693	protein deglycase activity
F8M43_RS14000	COG1621	beta-fructofuranosidase activity
F8M43_RS14005	COG3716	PTS system mannose fructose sorbose family IID component
F8M43_RS14010	COG3715	PTS system
F8M43_RS14015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS14020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS14025	COG3933	PFAM sigma-54 factor interaction domain-containing protein
F8M43_RS14025	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F8M43_RS14035	COG1113	amino acid transport
F8M43_RS14040	COG1280	lysine exporter protein (LysE YggA)
F8M43_RS14045	COG1378	Sugar-specific transcriptional regulator TrmB
F8M43_RS14050	COG1595	DNA-templated transcription, initiation
F8M43_RS14070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F8M43_RS14070	COG2124	cytochrome p450
F8M43_RS14075	COG1309	transcriptional regulator
F8M43_RS14080	COG2226	methyltransferase
F8M43_RS14095	COG2116	formate transmembrane transporter activity
F8M43_RS14100	COG5609	conserved protein (DUF2294)
F8M43_RS14105	COG3383	formate dehydrogenase (NAD+) activity
F8M43_RS14110	COG2427	Protein of unknown function (DUF1641)
F8M43_RS14120	COG0626	cystathionine gamma-synthase activity
F8M43_RS14125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F8M43_RS14130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F8M43_RS14135	COG2226	methyltransferase
F8M43_RS14150	COG0768	penicillin binding
F8M43_RS14155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F8M43_RS14160	COG0572	uridine kinase
F8M43_RS14165	COG0826	peptidase U32
F8M43_RS14170	COG0826	peptidase U32
F8M43_RS14175	COG4122	O-methyltransferase activity
F8M43_RS14180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F8M43_RS14185	COG3906	Belongs to the UPF0473 family
F8M43_RS14190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F8M43_RS14195	COG4472	Bacterial protein of unknown function (DUF965)
F8M43_RS14200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F8M43_RS14205	COG0628	permease
F8M43_RS14210	COG1126	abc transporter atp-binding protein
F8M43_RS14215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS14220	COG0765	amino acid transport
F8M43_RS14225	COG0765	amino acid transport
F8M43_RS14240	COG3881	PFAM PRC-barrel domain
F8M43_RS14245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F8M43_RS14250	COG0457	Tetratricopeptide repeat
F8M43_RS14255	COG0482	sulfurtransferase activity
F8M43_RS14260	COG1104	cysteine desulfurase activity
F8M43_RS14265	COG1959	2 iron, 2 sulfur cluster binding
F8M43_RS14270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F8M43_RS14275	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
F8M43_RS14285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F8M43_RS14290	COG0124	histidyl-tRNA synthetase
F8M43_RS14300	COG3103	Sh3 type 3 domain protein
F8M43_RS14300	COG4991	sh3 domain protein
F8M43_RS14300	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS14305	COG1490	D-aminoacyl-tRNA deacylase activity
F8M43_RS14310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
F8M43_RS14315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F8M43_RS14320	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F8M43_RS14320	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F8M43_RS14325	COG5416	Lipopolysaccharide assembly protein A domain
F8M43_RS14330	COG0490	domain, Protein
F8M43_RS14335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8M43_RS14335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F8M43_RS14345	COG2244	polysaccharide biosynthetic process
F8M43_RS14350	COG2323	membrane
F8M43_RS14360	COG1862	Preprotein translocase
F8M43_RS14365	COG0343	queuine tRNA-ribosyltransferase activity
F8M43_RS14370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F8M43_RS14380	COG2255	four-way junction helicase activity
F8M43_RS14385	COG0632	four-way junction helicase activity
F8M43_RS14395	COG2814	Major facilitator Superfamily
F8M43_RS14400	COG0673	inositol 2-dehydrogenase activity
F8M43_RS14405	COG2112	serine threonine protein kinase
F8M43_RS14425	COG1115	amino acid carrier protein
F8M43_RS14430	COG0217	transcriptional regulatory protein
F8M43_RS14440	COG1388	LysM domain
F8M43_RS14445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F8M43_RS14450	COG0157	Belongs to the NadC ModD family
F8M43_RS14455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F8M43_RS14460	COG1104	cysteine desulfurase activity
F8M43_RS14465	COG1827	regulation of RNA biosynthetic process
F8M43_RS14470	COG0077	Prephenate dehydratase
F8M43_RS14475	COG4492	Belongs to the UPF0735 family
F8M43_RS14480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F8M43_RS14485	COG3290	protein histidine kinase activity
F8M43_RS14495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F8M43_RS14500	COG2868	ribosomal protein
F8M43_RS14505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F8M43_RS14510	COG1994	Peptidase M50
F8M43_RS14515	COG0739	heme binding
F8M43_RS14520	COG2894	cell division
F8M43_RS14525	COG0850	regulation of cytokinetic process
F8M43_RS14530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
F8M43_RS14540	COG1077	Cell shape determining protein MreB Mrl
F8M43_RS14545	COG2003	Belongs to the UPF0758 family
F8M43_RS14550	COG0424	maF-like protein
F8M43_RS14560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
F8M43_RS14565	COG0285	dihydrofolate synthase activity
F8M43_RS14570	COG0525	valine-tRNA ligase activity
F8M43_RS14580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8M43_RS14585	COG1388	LysM domain
F8M43_RS14590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F8M43_RS14595	COG0113	porphobilinogen synthase activity
F8M43_RS14600	COG1587	Uroporphyrinogen-III synthase
F8M43_RS14605	COG0181	hydroxymethylbilane synthase activity
F8M43_RS14610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F8M43_RS14615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F8M43_RS14625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F8M43_RS14630	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F8M43_RS14635	COG1067	ATP-dependent peptidase activity
F8M43_RS14635	COG0470	DNA polymerase III
F8M43_RS14640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F8M43_RS14645	COG0544	peptidyl-prolyl cis-trans isomerase activity
F8M43_RS14650	COG1477	protein flavinylation
F8M43_RS14650	COG0457	Tetratricopeptide repeat
F8M43_RS14655	COG0066	3-isopropylmalate dehydratase activity
F8M43_RS14660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F8M43_RS14665	COG0473	3-isopropylmalate dehydrogenase activity
F8M43_RS14670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F8M43_RS14675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F8M43_RS14680	COG0440	acetolactate synthase activity
F8M43_RS14685	COG0028	Belongs to the TPP enzyme family
F8M43_RS14695	COG0454	-acetyltransferase
F8M43_RS14700	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
F8M43_RS14710	COG0622	Phosphoesterase
F8M43_RS14715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F8M43_RS14720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F8M43_RS14725	COG5401	PFAM Sporulation and spore germination
F8M43_RS14730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F8M43_RS14735	COG1846	Transcriptional regulator
F8M43_RS14740	COG2197	response regulator
F8M43_RS14745	COG0824	Thioesterase
F8M43_RS14750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
F8M43_RS14755	COG1053	succinate dehydrogenase
F8M43_RS14760	COG2009	succinate dehydrogenase
F8M43_RS14765	COG1719	4-vinyl reductase, 4VR
F8M43_RS14770	COG0527	aspartate kinase activity
F8M43_RS14780	COG0322	excinuclease ABC activity
F8M43_RS14785	COG3118	belongs to the thioredoxin family
F8M43_RS14795	COG3534	alpha-L-arabinofuranosidase
F8M43_RS14800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F8M43_RS14805	COG2086	electron transfer activity
F8M43_RS14810	COG1024	Enoyl-CoA hydratase
F8M43_RS14815	COG1309	transcriptional regulator
F8M43_RS14820	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS14825	COG3766	membrane
F8M43_RS14830	COG1193	negative regulation of DNA recombination
F8M43_RS14835	COG1796	DNA polymerase
F8M43_RS14835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8M43_RS14840	COG1286	toxin biosynthetic process
F8M43_RS14845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
F8M43_RS14850	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F8M43_RS14855	COG0072	phenylalanine-tRNA ligase activity
F8M43_RS14855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M43_RS14860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F8M43_RS14870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F8M43_RS14880	COG3835	regulator
F8M43_RS14885	COG0277	FAD linked oxidase domain protein
F8M43_RS14890	COG0247	lactate metabolic process
F8M43_RS14895	COG0346	lactoylglutathione lyase activity
F8M43_RS14905	COG1966	Carbon starvation protein
F8M43_RS14910	COG3534	alpha-L-arabinofuranosidase
F8M43_RS14915	COG0395	ABC-type sugar transport system, permease component
F8M43_RS14920	COG1175	transmembrane transport
F8M43_RS14925	COG1653	transport
F8M43_RS14930	COG0371	Dehydrogenase
F8M43_RS14935	COG0647	UMP catabolic process
F8M43_RS14940	COG0235	Class ii aldolase
F8M43_RS14945	COG1069	ribulokinase activity
F8M43_RS14950	COG2160	L-arabinose isomerase activity
F8M43_RS14955	COG3507	Belongs to the glycosyl hydrolase 43 family
F8M43_RS14960	COG1363	Peptidase, m42
F8M43_RS14970	COG3326	Membrane
F8M43_RS14975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F8M43_RS14980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F8M43_RS14985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F8M43_RS14995	COG1346	cytolysis
F8M43_RS15000	COG1380	Effector of murein hydrolase LrgA
F8M43_RS15005	COG3279	Response regulator of the LytR AlgR family
F8M43_RS15010	COG3275	phosphorelay sensor kinase activity
F8M43_RS15015	COG1011	Hydrolase
F8M43_RS15020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8M43_RS15030	COG0398	Pfam SNARE associated Golgi protein
F8M43_RS15035	COG1484	DNA-dependent DNA replication
F8M43_RS15040	COG3611	Membrane attachment protein
F8M43_RS15045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F8M43_RS15050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F8M43_RS15055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F8M43_RS15060	COG1733	regulation of RNA biosynthetic process
F8M43_RS15065	COG2814	Major facilitator Superfamily
F8M43_RS15070	COG0656	L-ascorbic acid biosynthetic process
F8M43_RS15075	COG0237	dephospho-CoA kinase activity
F8M43_RS15080	COG1971	Probably functions as a manganese efflux pump
F8M43_RS15085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F8M43_RS15090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8M43_RS15090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F8M43_RS15095	COG5002	protein histidine kinase activity
F8M43_RS15100	COG0745	RESPONSE REGULATOR receiver
F8M43_RS15105	COG0039	L-malate dehydrogenase activity
F8M43_RS15110	COG0538	isocitrate dehydrogenase activity
F8M43_RS15115	COG0372	Belongs to the citrate synthase family
F8M43_RS15120	COG2707	UPF0756 membrane protein
F8M43_RS15125	COG0628	permease
F8M43_RS15130	COG3030	protein affecting phage T7 exclusion by the F plasmid
F8M43_RS15135	COG0469	pyruvate kinase activity
F8M43_RS15140	COG0205	6-phosphofructokinase activity
F8M43_RS15145	COG0825	malonyl-CoA metabolic process
F8M43_RS15150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F8M43_RS15155	COG0281	malic enzyme
F8M43_RS15160	COG0587	DNA-directed DNA polymerase activity
F8M43_RS15180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
F8M43_RS15190	COG4109	DRTGG domain
F8M43_RS15195	COG0730	response to heat
F8M43_RS15200	COG1473	amidohydrolase
F8M43_RS15205	COG0196	riboflavin kinase activity
F8M43_RS15210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS15215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F8M43_RS15220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS15225	COG1126	abc transporter atp-binding protein
F8M43_RS15230	COG0765	amino acid transport
F8M43_RS15235	COG0765	amino acid transport
F8M43_RS15240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS15245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS15250	COG0454	-acetyltransferase
F8M43_RS15255	COG0583	DNA-binding transcription factor activity
F8M43_RS15260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F8M43_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS15275	COG0165	Argininosuccinate lyase
F8M43_RS15280	COG0137	argininosuccinate synthase activity
F8M43_RS15285	COG0521	Mo-molybdopterin cofactor biosynthetic process
F8M43_RS15290	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F8M43_RS15300	COG0827	DNA restriction-modification system
F8M43_RS15305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
F8M43_RS15310	COG3874	Sporulation protein YtfJ
F8M43_RS15320	COG1714	RDD family
F8M43_RS15325	COG0616	signal peptide processing
F8M43_RS15330	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F8M43_RS15335	COG1574	metal-dependent hydrolase with the TIM-barrel fold
F8M43_RS15340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8M43_RS15350	COG0301	tRNA thio-modification
F8M43_RS15355	COG1104	cysteine desulfurase activity
F8M43_RS15360	COG1114	Component of the transport system for branched-chain amino acids
F8M43_RS15365	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
F8M43_RS15370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F8M43_RS15375	COG1309	transcriptional regulator
F8M43_RS15380	COG1956	GAF domain-containing protein
F8M43_RS15385	COG2203	Gaf domain
F8M43_RS15385	COG2199	diguanylate cyclase activity
F8M43_RS15395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F8M43_RS15400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8M43_RS15405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F8M43_RS15410	COG0454	-acetyltransferase
F8M43_RS15415	COG0517	IMP dehydrogenase activity
F8M43_RS15420	COG0123	including yeast histone deacetylase and acetoin utilization protein
F8M43_RS15425	COG1360	Flagellar Motor Protein
F8M43_RS15430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F8M43_RS15435	COG1609	Transcriptional regulator
F8M43_RS15440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F8M43_RS15440	COG1605	Chorismate mutase
F8M43_RS15445	COG3118	belongs to the thioredoxin family
F8M43_RS15450	COG4980	gas vesicle protein
F8M43_RS15455	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
F8M43_RS15460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F8M43_RS15465	COG1674	ftsk spoiiie
F8M43_RS15470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F8M43_RS15475	COG4848	Belongs to the UPF0354 family
F8M43_RS15480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS15495	COG1363	Peptidase, m42
F8M43_RS15500	COG5584	Small secreted protein
F8M43_RS15505	COG0281	malic enzyme
F8M43_RS15510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS15515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F8M43_RS15525	COG0510	thiamine kinase activity
F8M43_RS15530	COG1523	belongs to the glycosyl hydrolase 13 family
F8M43_RS15535	COG1597	lipid kinase activity
F8M43_RS15545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F8M43_RS15550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F8M43_RS15555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M43_RS15560	COG2252	PERMEase
F8M43_RS15565	COG4473	ABC transporter
F8M43_RS15570	COG1131	(ABC) transporter
F8M43_RS15575	COG1349	DNA-binding transcription factor activity
F8M43_RS15580	COG1187	pseudouridine synthase activity
F8M43_RS15585	COG2244	polysaccharide biosynthetic process
F8M43_RS15590	COG2081	HI0933 family
F8M43_RS15595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
F8M43_RS15605	COG5578	integral membrane protein
F8M43_RS15610	COG0673	inositol 2-dehydrogenase activity
F8M43_RS15615	COG1653	transport
F8M43_RS15620	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
F8M43_RS15625	COG4209	transmembrane transport
F8M43_RS15630	COG2207	Transcriptional regulator
F8M43_RS15635	COG1653	transport
F8M43_RS15640	COG0395	ABC-type sugar transport system, permease component
F8M43_RS15645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M43_RS15650	COG2124	cytochrome p450
F8M43_RS15655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F8M43_RS15665	COG0156	8-amino-7-oxononanoate synthase activity
F8M43_RS15670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F8M43_RS15680	COG1073	alpha beta
F8M43_RS15685	COG1609	Transcriptional regulator
F8M43_RS15690	COG1653	transport
F8M43_RS15695	COG1175	transmembrane transport
F8M43_RS15700	COG0395	ABC-type sugar transport system, permease component
F8M43_RS15705	COG1486	melibiose metabolic process
F8M43_RS15710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F8M43_RS15715	COG0495	leucyl-tRNA aminoacylation
F8M43_RS15725	COG1366	Belongs to the anti-sigma-factor antagonist family
F8M43_RS15725	COG2202	Pas domain
F8M43_RS15730	COG2814	Major facilitator Superfamily
F8M43_RS15735	COG2433	Pfam Transposase IS66
F8M43_RS15740	COG0577	efflux transmembrane transporter activity
F8M43_RS15745	COG1136	(ABC) transporter
F8M43_RS15750	COG2205	protein histidine kinase activity
F8M43_RS15755	COG0745	RESPONSE REGULATOR receiver
F8M43_RS15760	COG0577	efflux transmembrane transporter activity
F8M43_RS15765	COG1136	(ABC) transporter
F8M43_RS15780	COG1131	(ABC) transporter
F8M43_RS15785	COG1725	Transcriptional regulator
F8M43_RS15800	COG1242	4 iron, 4 sulfur cluster binding
F8M43_RS15805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F8M43_RS15815	COG2267	carboxylic ester hydrolase activity
F8M43_RS15820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F8M43_RS15825	COG1113	amino acid transport
F8M43_RS15830	COG0367	asparagine synthase
F8M43_RS15835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F8M43_RS15840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F8M43_RS15850	COG1506	peptidase
F8M43_RS15855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F8M43_RS15860	COG1116	anion transmembrane transporter activity
F8M43_RS15865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F8M43_RS15870	COG0494	nUDIX hydrolase
F8M43_RS15875	COG4824	toxin secretion phage lysis holin
F8M43_RS15880	COG0783	Belongs to the Dps family
F8M43_RS15895	COG1854	S-ribosylhomocysteine lyase activity
F8M43_RS15900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F8M43_RS15905	COG0288	reversible hydration of carbon dioxide
F8M43_RS15910	COG0254	rRNA binding
F8M43_RS15915	COG1271	oxidase subunit
F8M43_RS15920	COG1294	oxidase, subunit
F8M43_RS15930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8M43_RS15935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F8M43_RS15935	COG1321	iron dependent repressor
F8M43_RS15940	COG1121	(ABC) transporter
F8M43_RS15945	COG0803	Belongs to the bacterial solute-binding protein 9 family
F8M43_RS15950	COG4948	Mandelate Racemase Muconate Lactonizing
F8M43_RS15955	COG0318	PFAM AMP-dependent synthetase and ligase
F8M43_RS15960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F8M43_RS15965	COG0596	Alpha beta hydrolase
F8M43_RS15970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
F8M43_RS15975	COG1169	isochorismate synthase
F8M43_RS15985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
F8M43_RS15990	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8M43_RS15995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8M43_RS16000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F8M43_RS16005	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS16015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8M43_RS16020	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS16025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8M43_RS16030	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F8M43_RS16035	COG0058	SHG alpha-glucan phosphorylase activity
F8M43_RS16040	COG0297	glycogen (starch) synthase activity
F8M43_RS16045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8M43_RS16050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F8M43_RS16055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F8M43_RS16180	COG3859	Proton-coupled thiamine transporter YuaJ
F8M43_RS16185	COG1247	-acetyltransferase
F8M43_RS16190	COG2268	Band 7 protein
F8M43_RS16195	COG1585	Membrane protein implicated in regulation of membrane protease activity
F8M43_RS16200	COG2318	DinB family
F8M43_RS16210	COG1454	alcohol dehydrogenase
F8M43_RS16215	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS16220	COG1510	regulation of RNA biosynthetic process
F8M43_RS16230	COG0569	domain protein
F8M43_RS16235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F8M43_RS16240	COG4682	membrane
F8M43_RS16245	COG1705	Flagellar rod assembly protein muramidase FlgJ
F8M43_RS16250	COG0477	Major facilitator Superfamily
F8M43_RS16255	COG5553	Cysteine dioxygenase type I
F8M43_RS16265	COG1968	undecaprenyl-diphosphatase activity
F8M43_RS16270	COG0628	permease
F8M43_RS16275	COG0673	inositol 2-dehydrogenase activity
F8M43_RS16280	COG4806	L-rhamnose isomerase
F8M43_RS16285	COG3254	rhamnose metabolic process
F8M43_RS16290	COG1070	Carbohydrate kinase
F8M43_RS16295	COG1349	DNA-binding transcription factor activity
F8M43_RS16300	COG3347	Dehydrogenase
F8M43_RS16300	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS16310	COG0840	transmembrane signaling receptor activity
F8M43_RS16315	COG0840	transmembrane signaling receptor activity
F8M43_RS16320	COG0840	transmembrane signaling receptor activity
F8M43_RS16325	COG0840	transmembrane signaling receptor activity
F8M43_RS16340	COG0432	Pfam Uncharacterised protein family UPF0047
F8M43_RS16350	COG0366	Alpha amylase catalytic
F8M43_RS16355	COG1253	flavin adenine dinucleotide binding
F8M43_RS16360	COG2738	Putative neutral zinc metallopeptidase
F8M43_RS16375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F8M43_RS16390	COG0166	Belongs to the GPI family
F8M43_RS16395	COG1979	alcohol dehydrogenase
F8M43_RS16400	COG1979	alcohol dehydrogenase
F8M43_RS16405	COG2155	Conserved Protein
F8M43_RS16410	COG1098	S1 RNA binding domain
F8M43_RS16415	COG0436	Aminotransferase
F8M43_RS16420	COG1522	sequence-specific DNA binding
F8M43_RS16425	COG2267	carboxylic ester hydrolase activity
F8M43_RS16435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
F8M43_RS16440	COG2205	protein histidine kinase activity
F8M43_RS16450	COG5018	Exonuclease
F8M43_RS16460	COG2814	Major facilitator Superfamily
F8M43_RS16465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M43_RS16470	COG3011	Protein conserved in bacteria
F8M43_RS16480	COG3290	protein histidine kinase activity
F8M43_RS16485	COG4565	transcriptional regulatory protein
F8M43_RS16490	COG1744	ABC transporter substrate-binding protein PnrA-like
F8M43_RS16495	COG3845	ABC transporter
F8M43_RS16500	COG4603	Belongs to the binding-protein-dependent transport system permease family
F8M43_RS16505	COG1079	Belongs to the binding-protein-dependent transport system permease family
F8M43_RS16510	COG3493	citrate carrier protein
F8M43_RS16520	COG2111	Na H antiporter
F8M43_RS16520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F8M43_RS16525	COG2111	Na H antiporter
F8M43_RS16530	COG1006	Multisubunit Na H antiporter MnhC subunit
F8M43_RS16535	COG0651	ATP synthesis coupled electron transport
F8M43_RS16540	COG1863	multisubunit Na H antiporter MnhE subunit
F8M43_RS16545	COG2212	antiporter activity
F8M43_RS16550	COG1320	monovalent cation:proton antiporter activity
F8M43_RS16555	COG2050	protein possibly involved in aromatic compounds catabolism
F8M43_RS16560	COG2197	response regulator
F8M43_RS16565	COG4585	Histidine kinase
F8M43_RS16575	COG0142	geranyltranstransferase activity
F8M43_RS16595	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
F8M43_RS16600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
F8M43_RS16605	COG1335	isochorismatase
F8M43_RS16610	COG5506	Protein of unknown function (DUF1694)
F8M43_RS16625	COG0628	permease
F8M43_RS16640	COG1418	mRNA catabolic process
F8M43_RS16645	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS16655	COG1511	domain protein
F8M43_RS16660	COG1674	ftsk spoiiie
F8M43_RS16660	COG0433	COG0433 Predicted ATPase
F8M43_RS16665	COG4499	WXG100 protein secretion system (Wss), protein YukC
F8M43_RS16670	COG5417	Belongs to the EsaB family
F8M43_RS16675	COG4842	Belongs to the WXG100 family
F8M43_RS16680	COG2508	Transcriptional regulator
F8M43_RS16680	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
F8M43_RS16685	COG0686	Belongs to the AlaDH PNT family
F8M43_RS16690	COG5634	Uncharacterized conserved protein (DUF2278)
F8M43_RS16695	COG3251	PFAM MbtH domain protein
F8M43_RS16700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS16705	COG1535	isochorismatase
F8M43_RS16705	COG3433	isochorismatase activity
F8M43_RS16710	COG1021	2,3-dihydroxybenzoate-AMP ligase
F8M43_RS16715	COG1169	isochorismate synthase
F8M43_RS16720	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS16725	COG2819	hydrolase of the alpha beta superfamily
F8M43_RS16730	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F8M43_RS16735	COG1268	BioY protein
F8M43_RS16740	COG2056	Na+-H+ antiporter family
F8M43_RS16745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F8M43_RS16750	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
F8M43_RS16755	COG3584	3D domain protein
F8M43_RS16770	COG1252	NADH dehydrogenase
F8M43_RS16775	COG0492	ferredoxin-NADP+ reductase activity
F8M43_RS16785	COG0516	GMP reductase activity
F8M43_RS16790	COG2808	Putative FMN-binding domain
F8M43_RS16795	COG0456	acetyltransferase
F8M43_RS16800	COG0316	Belongs to the HesB IscA family
F8M43_RS16805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F8M43_RS16810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F8M43_RS16815	COG4844	belongs to the
F8M43_RS16820	COG1252	NADH dehydrogenase
F8M43_RS16825	COG4837	Protein of unknown function (DUF1462)
F8M43_RS16830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F8M43_RS16835	COG1506	peptidase
F8M43_RS16835	COG0823	Involved in the tonB-independent uptake of proteins
F8M43_RS16835	COG4946	Tricorn protease homolog
F8M43_RS16840	COG0083	homoserine kinase activity
F8M43_RS16845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
F8M43_RS16850	COG0460	homoserine dehydrogenase
F8M43_RS16855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F8M43_RS16860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F8M43_RS16865	COG0647	UMP catabolic process
F8M43_RS16870	COG2445	Protein of unknown function DUF86
F8M43_RS16875	COG4470	Protein conserved in bacteria
F8M43_RS16885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F8M43_RS16890	COG0739	heme binding
F8M43_RS16900	COG3377	Domain of unknown function (DUF1805)
F8M43_RS16905	COG0737	Belongs to the 5'-nucleotidase family
F8M43_RS16910	COG0730	response to heat
F8M43_RS16915	COG1801	Protein of unknown function DUF72
F8M43_RS16925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F8M43_RS16930	COG2508	Transcriptional regulator
F8M43_RS16935	COG2233	PERMEase
F8M43_RS16940	COG2233	PERMEase
F8M43_RS16945	COG3195	allantoin biosynthetic process
F8M43_RS16945	COG3648	Uricase
F8M43_RS16950	COG2351	hydroxyisourate hydrolase activity
F8M43_RS16960	COG2080	2 iron, 2 sulfur cluster binding
F8M43_RS16965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F8M43_RS16970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
F8M43_RS16975	COG2068	MobA-Related Protein
F8M43_RS16980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F8M43_RS16985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F8M43_RS16990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F8M43_RS17000	COG2356	endonuclease I
F8M43_RS17005	COG3842	ATPase activity
F8M43_RS17010	COG2188	Transcriptional regulator
F8M43_RS17015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M43_RS17020	COG0395	ABC-type sugar transport system, permease component
F8M43_RS17025	COG1175	transmembrane transport
F8M43_RS17030	COG1653	transport
F8M43_RS17035	COG2222	sugar isomerase
F8M43_RS17040	COG0322	excinuclease ABC activity
F8M43_RS17045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F8M43_RS17060	COG0346	lactoylglutathione lyase activity
F8M43_RS17065	COG0640	Transcriptional regulator
F8M43_RS17070	COG0719	Fe-S assembly protein
F8M43_RS17075	COG0822	iron-sulfur transferase activity
F8M43_RS17080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F8M43_RS17085	COG0719	Fe-S assembly protein
F8M43_RS17090	COG0396	ATPase activity
F8M43_RS17105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F8M43_RS17110	COG1464	Belongs to the NlpA lipoprotein family
F8M43_RS17115	COG2011	ABC-type metal ion transport system permease component
F8M43_RS17120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F8M43_RS17130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F8M43_RS17135	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
F8M43_RS17145	COG0509	glycine decarboxylation via glycine cleavage system
F8M43_RS17150	COG1393	Belongs to the ArsC family
F8M43_RS17155	COG1960	acyl-CoA dehydrogenase activity
F8M43_RS17160	COG0183	Belongs to the thiolase family
F8M43_RS17165	COG1250	3-hydroxyacyl-CoA dehydrogenase
F8M43_RS17165	COG1024	Enoyl-CoA hydratase
F8M43_RS17175	COG0506	proline dehydrogenase activity
F8M43_RS17185	COG5577	PFAM Coat F domain
F8M43_RS17190	COG1846	Transcriptional regulator
F8M43_RS17195	COG0477	Major facilitator Superfamily
F8M43_RS17200	COG1942	4-Oxalocrotonate Tautomerase
F8M43_RS17205	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS17210	COG0583	DNA-binding transcription factor activity
F8M43_RS17220	COG1120	ATPase activity
F8M43_RS17235	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS17240	COG0783	Belongs to the Dps family
F8M43_RS17245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M43_RS17250	COG0745	RESPONSE REGULATOR receiver
F8M43_RS17255	COG2205	protein histidine kinase activity
F8M43_RS17255	COG2770	Histidine kinase
F8M43_RS17265	COG1309	transcriptional regulator
F8M43_RS17270	COG0114	fumarate hydratase activity
F8M43_RS17280	COG0697	spore germination
F8M43_RS17285	COG0814	amino acid
F8M43_RS17295	COG2197	response regulator
F8M43_RS17300	COG4585	Histidine kinase
F8M43_RS17305	COG4758	membrane
F8M43_RS17310	COG3595	metallopeptidase activity
F8M43_RS17315	COG1842	Phage shock protein A
F8M43_RS17320	COG4758	membrane
F8M43_RS17325	COG2814	Major facilitator Superfamily
F8M43_RS17330	COG2096	Adenosyltransferase
F8M43_RS17335	COG1120	ATPase activity
F8M43_RS17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS17345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS17350	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS17355	COG3386	PFAM SMP-30 Gluconolaconase
F8M43_RS17360	COG2205	protein histidine kinase activity
F8M43_RS17365	COG0745	RESPONSE REGULATOR receiver
F8M43_RS17375	COG1191	sigma factor activity
F8M43_RS17385	COG2140	Oxalate decarboxylase
F8M43_RS17395	COG0577	efflux transmembrane transporter activity
F8M43_RS17400	COG1136	(ABC) transporter
F8M43_RS17405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F8M43_RS17410	COG1120	ATPase activity
F8M43_RS17415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS17420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F8M43_RS17425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS17435	COG0531	amino acid
F8M43_RS17450	COG1988	membrane-bound metal-dependent
F8M43_RS17455	COG1368	sulfuric ester hydrolase activity
F8M43_RS17460	COG1910	domain protein
F8M43_RS17465	COG0725	ABC transporter, periplasmic molybdate-binding protein
F8M43_RS17470	COG4149	molybdate abc transporter
F8M43_RS17475	COG0656	L-ascorbic acid biosynthetic process
F8M43_RS17485	COG0025	NhaP-type Na H and K H
F8M43_RS17490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F8M43_RS17495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
F8M43_RS17500	COG3973	AAA domain
F8M43_RS17510	COG2860	membrane
F8M43_RS17515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
F8M43_RS17520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F8M43_RS17525	COG2217	Heavy metal translocating P-type atpase
F8M43_RS17530	COG2217	Heavy metal translocating P-type atpase
F8M43_RS17535	COG2608	mercury ion transmembrane transporter activity
F8M43_RS17540	COG1937	Protein conserved in bacteria
F8M43_RS17545	COG0673	inositol 2-dehydrogenase activity
F8M43_RS17550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
F8M43_RS17555	COG1289	transmembrane transporter activity
F8M43_RS17565	COG2076	Multidrug Resistance protein
F8M43_RS17570	COG1309	transcriptional regulator
F8M43_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS17585	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F8M43_RS17590	COG0557	exoribonuclease II activity
F8M43_RS17595	COG1647	Serine aminopeptidase, S33
F8M43_RS17600	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F8M43_RS17605	COG0596	Alpha beta hydrolase
F8M43_RS17610	COG1476	TRANSCRIPTIONal
F8M43_RS17615	COG1396	sequence-specific DNA binding
F8M43_RS17620	COG1396	sequence-specific DNA binding
F8M43_RS17625	COG1733	regulation of RNA biosynthetic process
F8M43_RS17630	COG0840	transmembrane signaling receptor activity
F8M43_RS17635	COG1174	glycine betaine transport
F8M43_RS17640	COG1732	Glycine betaine
F8M43_RS17645	COG1174	glycine betaine transport
F8M43_RS17650	COG1125	glycine betaine transport
F8M43_RS17650	COG0517	IMP dehydrogenase activity
F8M43_RS17655	COG1510	regulation of RNA biosynthetic process
F8M43_RS17660	COG1174	glycine betaine transport
F8M43_RS17665	COG1732	Glycine betaine
F8M43_RS17670	COG1174	glycine betaine transport
F8M43_RS17675	COG0517	IMP dehydrogenase activity
F8M43_RS17675	COG1125	glycine betaine transport
F8M43_RS17680	COG1510	regulation of RNA biosynthetic process
F8M43_RS17685	COG2095	MarC family integral membrane protein
F8M43_RS17695	COG3064	Membrane
F8M43_RS17700	COG4640	response to antibiotic
F8M43_RS17705	COG0456	acetyltransferase
F8M43_RS17710	COG0148	phosphopyruvate hydratase activity
F8M43_RS17715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F8M43_RS17720	COG0149	triose-phosphate isomerase activity
F8M43_RS17725	COG0126	phosphoglycerate kinase activity
F8M43_RS17730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F8M43_RS17735	COG2390	Transcriptional regulator
F8M43_RS17740	COG2814	Major facilitator Superfamily
F8M43_RS17745	COG1609	Transcriptional regulator
F8M43_RS17750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS17760	COG0583	DNA-binding transcription factor activity
F8M43_RS17765	COG0697	spore germination
F8M43_RS17770	COG1113	amino acid transport
F8M43_RS17775	COG3858	chitin binding
F8M43_RS17780	COG1556	Lactate utilization protein
F8M43_RS17785	COG1139	Iron-sulfur cluster binding protein
F8M43_RS17790	COG0247	lactate metabolic process
F8M43_RS17795	COG2197	response regulator
F8M43_RS17800	COG4585	Histidine kinase
F8M43_RS17805	COG0842	Transport permease protein
F8M43_RS17810	COG1131	(ABC) transporter
F8M43_RS17815	COG0596	Alpha beta hydrolase
F8M43_RS17820	COG2208	phosphoserine phosphatase activity
F8M43_RS17825	COG3867	Arabinogalactan endo-beta-1,4-galactanase
F8M43_RS17830	COG1874	Beta-galactosidase
F8M43_RS17835	COG3833	ABC-type maltose transport systems, permease component
F8M43_RS17840	COG1175	transmembrane transport
F8M43_RS17845	COG2182	Extracellular solute-binding protein
F8M43_RS17850	COG1609	Transcriptional regulator
F8M43_RS17855	COG2186	Transcriptional regulator
F8M43_RS17860	COG1620	l-lactate permease
F8M43_RS17865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F8M43_RS17875	COG5039	Polysaccharide pyruvyl transferase
F8M43_RS17880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M43_RS17885	COG0110	maltose O-acetyltransferase activity
F8M43_RS17890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F8M43_RS17895	COG2244	polysaccharide biosynthetic process
F8M43_RS17900	COG1216	Glycosyl transferase, family 2
F8M43_RS17905	COG5039	Polysaccharide pyruvyl transferase
F8M43_RS17910	COG1216	Glycosyl transferase, family 2
F8M43_RS17920	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS17925	COG1215	transferase activity, transferring glycosyl groups
F8M43_RS17930	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS17935	COG1086	Polysaccharide biosynthesis protein
F8M43_RS17940	COG0489	protein tyrosine kinase activity
F8M43_RS17945	COG3944	biosynthesis protein
F8M43_RS17950	COG1396	sequence-specific DNA binding
F8M43_RS17955	COG2272	Belongs to the type-B carboxylesterase lipase family
F8M43_RS17965	COG3479	Phenolic acid decarboxylase
F8M43_RS17975	COG1794	racemase activity, acting on amino acids and derivatives
F8M43_RS17980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F8M43_RS17985	COG1621	beta-fructofuranosidase activity
F8M43_RS17990	COG1621	beta-fructofuranosidase activity
F8M43_RS17995	COG0531	amino acid
F8M43_RS18000	COG1309	transcriptional regulator
F8M43_RS18005	COG2076	Multidrug Resistance protein
F8M43_RS18010	COG2076	Multidrug Resistance protein
F8M43_RS18020	COG0277	FAD linked oxidase domain protein
F8M43_RS18025	COG3621	Patatin-like phospholipase
F8M43_RS18035	COG0740	serine-type endopeptidase activity
F8M43_RS18040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F8M43_RS18045	COG0366	Alpha amylase catalytic
F8M43_RS18050	COG1554	hydrolase, family 65, central catalytic
F8M43_RS18055	COG5521	maltodextrose utilization protein MalA
F8M43_RS18060	COG3833	ABC-type maltose transport systems, permease component
F8M43_RS18065	COG1175	transmembrane transport
F8M43_RS18070	COG2182	Extracellular solute-binding protein
F8M43_RS18075	COG0366	Alpha amylase catalytic
F8M43_RS18080	COG1609	Transcriptional regulator
F8M43_RS18085	COG1611	Belongs to the LOG family
F8M43_RS18090	COG1694	Mazg nucleotide pyrophosphohydrolase
F8M43_RS18095	COG0659	secondary active sulfate transmembrane transporter activity
F8M43_RS18100	COG0288	reversible hydration of carbon dioxide
F8M43_RS18105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F8M43_RS18110	COG0577	efflux transmembrane transporter activity
F8M43_RS18115	COG1136	(ABC) transporter
F8M43_RS18120	COG5002	protein histidine kinase activity
F8M43_RS18125	COG0745	RESPONSE REGULATOR receiver
F8M43_RS18135	COG2162	N-hydroxyarylamine O-acetyltransferase activity
F8M43_RS18140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS18145	COG1481	regulation of sporulation
F8M43_RS18150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
F8M43_RS18155	COG1660	Displays ATPase and GTPase activities
F8M43_RS18160	COG1051	belongs to the nudix hydrolase family
F8M43_RS18165	COG0492	ferredoxin-NADP+ reductase activity
F8M43_RS18170	COG3883	PFAM NLP P60 protein
F8M43_RS18170	COG0791	NLP P60 protein
F8M43_RS18175	COG0457	Tetratricopeptide repeat
F8M43_RS18180	COG1132	(ABC) transporter
F8M43_RS18200	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F8M43_RS18200	COG0140	phosphoribosyl-ATP diphosphatase activity
F8M43_RS18205	COG0107	imidazoleglycerol-phosphate synthase activity
F8M43_RS18210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F8M43_RS18215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F8M43_RS18220	COG0131	Imidazoleglycerol-phosphate dehydratase
F8M43_RS18225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F8M43_RS18230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F8M43_RS18235	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F8M43_RS18240	COG4990	cell redox homeostasis
F8M43_RS18245	COG5297	Belongs to the glycosyl hydrolase family 6
F8M43_RS18250	COG0110	maltose O-acetyltransferase activity
F8M43_RS18255	COG0546	phosphoglycolate phosphatase activity
F8M43_RS18260	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F8M43_RS18265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F8M43_RS18270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F8M43_RS18275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F8M43_RS18280	COG0363	glucosamine-6-phosphate deaminase activity
F8M43_RS18285	COG2188	Transcriptional regulator
F8M43_RS18290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F8M43_RS18295	COG1846	Transcriptional regulator
F8M43_RS18310	COG1846	Transcriptional regulator
F8M43_RS18315	COG2814	Major facilitator Superfamily
F8M43_RS18320	COG1950	PFAM Membrane protein of
F8M43_RS18325	COG1983	PspC domain protein
F8M43_RS18330	COG3595	metallopeptidase activity
F8M43_RS18345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8M43_RS18350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F8M43_RS18355	COG0556	nucleotide-excision repair
F8M43_RS18360	COG4897	Protein conserved in bacteria
F8M43_RS18365	COG3848	Pyruvate phosphate dikinase
F8M43_RS18365	COG0574	Belongs to the PEP-utilizing enzyme family
F8M43_RS18370	COG1309	transcriptional regulator
F8M43_RS18375	COG2814	Major facilitator Superfamily
F8M43_RS18380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M43_RS18390	COG3409	Peptidoglycan-binding domain 1 protein
F8M43_RS18390	COG0793	Belongs to the peptidase S41A family
F8M43_RS18395	COG2177	Part of the ABC transporter FtsEX involved in
F8M43_RS18400	COG2884	Cell division ATP-binding protein ftsE
F8M43_RS18405	COG2010	Cytochrome c
F8M43_RS18410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS18420	COG0653	protein targeting
F8M43_RS18425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
F8M43_RS18440	COG1516	flagellar protein fliS
F8M43_RS18445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F8M43_RS18450	COG1334	flagellar protein FlaG
F8M43_RS18455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8M43_RS18460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
F8M43_RS18465	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
F8M43_RS18475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F8M43_RS18480	COG4786	Flagellar basal body rod
F8M43_RS18480	COG1256	bacterial-type flagellum assembly
F8M43_RS18485	COG3418	PFAM FlgN family protein
F8M43_RS18490	COG2747	anti-sigma28 factor FlgM
F8M43_RS18500	COG1040	competence protein
F8M43_RS18510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
F8M43_RS18515	COG1307	EDD domain protein, DegV family
F8M43_RS18520	COG2197	response regulator
F8M43_RS18525	COG4585	Histidine kinase
F8M43_RS18530	COG1739	Uncharacterized protein family UPF0029
F8M43_RS18535	COG1316	TRANSCRIPTIONal
F8M43_RS18540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F8M43_RS18545	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS18550	COG1215	transferase activity, transferring glycosyl groups
F8M43_RS18555	COG3206	protein involved in exopolysaccharide biosynthesis
F8M43_RS18560	COG3307	-O-antigen
F8M43_RS18565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8M43_RS18570	COG0438	transferase activity, transferring glycosyl groups
F8M43_RS18570	COG0297	glycogen (starch) synthase activity
F8M43_RS18575	COG2244	polysaccharide biosynthetic process
F8M43_RS18590	COG0860	N-Acetylmuramoyl-L-alanine amidase
F8M43_RS18590	COG2247	cell wall binding repeat
F8M43_RS18595	COG2247	cell wall binding repeat
F8M43_RS18595	COG2385	sporulation resulting in formation of a cellular spore
F8M43_RS18605	COG1316	TRANSCRIPTIONal
F8M43_RS18610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F8M43_RS18630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F8M43_RS18635	COG1134	teichoic acid transport
F8M43_RS18640	COG1682	transport, permease protein
F8M43_RS18655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F8M43_RS18655	COG1215	transferase activity, transferring glycosyl groups
F8M43_RS18660	COG0463	Glycosyl transferase, family 2
F8M43_RS18705	COG4193	domain, Protein
F8M43_RS18710	COG1482	cell wall glycoprotein biosynthetic process
F8M43_RS18715	COG0697	spore germination
F8M43_RS18720	COG0814	amino acid
F8M43_RS18730	COG2814	Major facilitator Superfamily
F8M43_RS18735	COG1316	TRANSCRIPTIONal
F8M43_RS18740	COG0561	phosphatase activity
F8M43_RS18745	COG0791	NLP P60 protein
F8M43_RS18755	COG2843	Capsule synthesis protein
F8M43_RS18765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F8M43_RS18770	COG1609	Transcriptional regulator
F8M43_RS18775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M43_RS18780	COG1869	D-ribose catabolic process
F8M43_RS18785	COG1129	ABC transporter
F8M43_RS18790	COG1172	Belongs to the binding-protein-dependent transport system permease family
F8M43_RS18795	COG1879	ABC-type sugar transport system periplasmic component
F8M43_RS18800	COG3103	Sh3 type 3 domain protein
F8M43_RS18810	COG2249	NAD(P)H dehydrogenase (quinone) activity
F8M43_RS18815	COG3527	Alpha-acetolactate decarboxylase
F8M43_RS18820	COG0028	Belongs to the TPP enzyme family
F8M43_RS18825	COG0583	DNA-binding transcription factor activity
F8M43_RS18830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
F8M43_RS18845	COG5337	Spore coat protein CotH
F8M43_RS18855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F8M43_RS18865	COG0405	Gamma-glutamyltransferase
F8M43_RS18870	COG1522	sequence-specific DNA binding
F8M43_RS18875	COG2059	Chromate
F8M43_RS18880	COG2059	Chromate
F8M43_RS18890	COG0655	NAD(P)H dehydrogenase (quinone) activity
F8M43_RS18895	COG0583	DNA-binding transcription factor activity
F8M43_RS18925	COG5444	nuclease activity
F8M43_RS18945	COG3878	Protein conserved in bacteria
F8M43_RS18950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F8M43_RS18955	COG4464	protein tyrosine phosphatase activity
F8M43_RS18960	COG0489	protein tyrosine kinase activity
F8M43_RS18965	COG3944	biosynthesis protein
F8M43_RS18975	COG4715	Zinc finger, swim domain protein
F8M43_RS18980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F8M43_RS18985	COG0561	phosphatase activity
F8M43_RS18990	COG1349	DNA-binding transcription factor activity
F8M43_RS18995	COG0629	single-stranded DNA binding
F8M43_RS19010	COG3764	Sortase (surface protein transpeptidase)
F8M43_RS19015	COG0745	RESPONSE REGULATOR receiver
F8M43_RS19015	COG2972	Histidine kinase
F8M43_RS19020	COG1970	mechanosensitive ion channel activity
F8M43_RS19025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F8M43_RS19030	COG0457	Tetratricopeptide repeat
F8M43_RS19035	COG4786	Flagellar basal body rod
F8M43_RS19040	COG4786	Flagellar basal body rod
F8M43_RS19045	COG1077	Cell shape determining protein MreB Mrl
F8M43_RS19050	COG1609	Transcriptional regulator
F8M43_RS19060	COG1846	Transcriptional regulator
F8M43_RS19065	COG2814	Major facilitator Superfamily
F8M43_RS19070	COG3420	alginic acid biosynthetic process
F8M43_RS19075	COG1953	Uracil, thiamine, allantoin
F8M43_RS19080	COG0477	Major facilitator Superfamily
F8M43_RS19085	COG1335	isochorismatase
F8M43_RS19095	COG0004	ammonium transporteR
F8M43_RS19100	COG0347	Belongs to the P(II) protein family
F8M43_RS19105	COG0671	phosphoesterase, PA-phosphatase related
F8M43_RS19115	COG0739	heme binding
F8M43_RS19120	COG1247	-acetyltransferase
F8M43_RS19140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M43_RS19145	COG0789	Transcriptional regulator
F8M43_RS19155	COG2910	NAD(P)H-binding
F8M43_RS19160	COG1959	2 iron, 2 sulfur cluster binding
F8M43_RS19165	COG0804	urea catabolic process
F8M43_RS19170	COG0832	Belongs to the urease beta subunit family
F8M43_RS19175	COG0831	urea catabolic process
F8M43_RS19190	COG3237	CsbD-like
F8M43_RS19195	COG1994	Peptidase M50
F8M43_RS19200	COG0457	Tetratricopeptide repeat
F8M43_RS19205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F8M43_RS19210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F8M43_RS19220	COG2304	oxidoreductase activity
F8M43_RS19230	COG2304	oxidoreductase activity
F8M43_RS19235	COG2385	sporulation resulting in formation of a cellular spore
F8M43_RS19240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8M43_RS19250	COG4836	Membrane
F8M43_RS19260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F8M43_RS19265	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F8M43_RS19270	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F8M43_RS19275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F8M43_RS19280	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F8M43_RS19285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F8M43_RS19295	COG0356	it plays a direct role in the translocation of protons across the membrane
F8M43_RS19305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F8M43_RS19310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F8M43_RS19315	COG4475	Protein of unknown function (DUF436)
F8M43_RS19320	COG0698	ribose 5-phosphate isomerase
F8M43_RS19325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F8M43_RS19330	COG1971	Probably functions as a manganese efflux pump
F8M43_RS19335	COG0009	L-threonylcarbamoyladenylate synthase
F8M43_RS19340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
F8M43_RS19360	COG2890	protein-(glutamine-N5) methyltransferase activity
F8M43_RS19365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F8M43_RS19370	COG0346	lactoylglutathione lyase activity
F8M43_RS19375	COG0789	Transcriptional regulator
F8M43_RS19380	COG0679	Auxin Efflux Carrier
F8M43_RS19385	COG0281	malic enzyme
F8M43_RS19390	COG1435	thymidine kinase activity
F8M43_RS19400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F8M43_RS19410	COG1494	fructose-1,6-bisphosphatase
F8M43_RS19415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F8M43_RS19420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F8M43_RS19425	COG0191	fructose-bisphosphate aldolase activity
F8M43_RS19430	COG2204	response regulator
F8M43_RS19435	COG4821	SIS domain
F8M43_RS19440	COG0504	CTP synthase activity
F8M43_RS19445	COG3343	RNA polymerase activity
F8M43_RS19450	COG1960	acyl-CoA dehydrogenase activity
F8M43_RS19455	COG0247	lactate metabolic process
F8M43_RS19455	COG2181	nitrate reductase activity
F8M43_RS19460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M43_RS19465	COG4294	response to UV
F8M43_RS19475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8M43_RS19480	COG1132	(ABC) transporter
F8M43_RS19485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F8M43_RS19500	COG2181	nitrate reductase activity
F8M43_RS19505	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F8M43_RS19510	COG1140	nitrate reductase beta subunit
F8M43_RS19515	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F8M43_RS19520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8M43_RS19530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F8M43_RS19535	COG2223	nitrite transmembrane transporter activity
F8M43_RS19540	COG0018	arginyl-trna synthetase
F8M43_RS19545	COG4506	Protein conserved in bacteria
F8M43_RS19560	COG0535	radical SAM domain protein
F8M43_RS19570	COG1131	(ABC) transporter
F8M43_RS19575	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F8M43_RS19580	COG0612	Peptidase, M16
F8M43_RS19585	COG0612	Peptidase, M16
F8M43_RS19595	COG3391	amine dehydrogenase activity
F8M43_RS19600	COG3391	amine dehydrogenase activity
F8M43_RS19610	COG0457	Tetratricopeptide repeat
F8M43_RS19640	COG1131	(ABC) transporter
F8M43_RS19650	COG0010	Belongs to the arginase family
F8M43_RS19655	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F8M43_RS19660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F8M43_RS19675	COG1994	Peptidase M50
F8M43_RS19680	COG1942	4-Oxalocrotonate Tautomerase
F8M43_RS19685	COG1846	Transcriptional regulator
F8M43_RS19690	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F8M43_RS19695	COG0477	Major facilitator Superfamily
F8M43_RS19700	COG1959	2 iron, 2 sulfur cluster binding
F8M43_RS19705	COG3465	dGTPase activity
F8M43_RS19710	COG1078	dGTPase activity
F8M43_RS19715	COG4844	belongs to the
F8M43_RS19725	COG0697	spore germination
F8M43_RS19730	COG0095	Lipoate-protein ligase
F8M43_RS19735	COG0583	DNA-binding transcription factor activity
F8M43_RS19740	COG0280	phosphate acetyltransferase
F8M43_RS19745	COG3253	May function as heme-dependent peroxidase
F8M43_RS19750	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS19755	COG0436	Aminotransferase
F8M43_RS19760	COG2814	Major facilitator Superfamily
F8M43_RS19765	COG0151	Belongs to the GarS family
F8M43_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS19775	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS19780	COG0077	Prephenate dehydratase
F8M43_RS19785	COG2814	Major facilitator Superfamily
F8M43_RS19790	COG0833	amino acid
F8M43_RS19795	COG4187	Peptidase family M20/M25/M40
F8M43_RS19800	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS19805	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F8M43_RS19815	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
F8M43_RS19820	COG1091	dTDP-4-dehydrorhamnose reductase activity
F8M43_RS19825	COG1088	dTDP-glucose 4,6-dehydratase activity
F8M43_RS19830	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
F8M43_RS19835	COG3980	spore coat polysaccharide biosynthesis protein
F8M43_RS19840	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
F8M43_RS19845	COG2089	acid synthase
F8M43_RS19850	COG0456	acetyltransferase
F8M43_RS19855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F8M43_RS19860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
F8M43_RS19865	COG0463	Glycosyl transferase, family 2
F8M43_RS19880	COG2363	Small membrane protein
F8M43_RS19885	COG2233	PERMEase
F8M43_RS19895	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS19900	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
F8M43_RS19905	COG1216	Glycosyl transferase, family 2
F8M43_RS19910	COG0351	phosphomethylpyrimidine kinase
F8M43_RS19920	COG1621	beta-fructofuranosidase activity
F8M43_RS19925	COG1263	PTS System
F8M43_RS19925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS19930	COG2116	formate transmembrane transporter activity
F8M43_RS19935	COG3711	transcriptional antiterminator
F8M43_RS19945	COG1404	Belongs to the peptidase S8 family
F8M43_RS19950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS19955	COG0778	Nitroreductase
F8M43_RS19960	COG0772	Belongs to the SEDS family
F8M43_RS19970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F8M43_RS19975	COG1845	cytochrome c oxidase, subunit III
F8M43_RS19980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F8M43_RS19985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F8M43_RS19990	COG2261	transglycosylase associated protein
F8M43_RS19995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
F8M43_RS20000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
F8M43_RS20005	COG2246	polysaccharide biosynthetic process
F8M43_RS20010	COG1309	transcriptional regulator
F8M43_RS20020	COG3162	membrane
F8M43_RS20025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F8M43_RS20030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
F8M43_RS20035	COG2837	iron assimilation
F8M43_RS20040	COG2822	iron ion transport
F8M43_RS20045	COG0672	)-iron permease
F8M43_RS20050	COG0352	thiamine-phosphate diphosphorylase activity
F8M43_RS20055	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
F8M43_RS20060	COG0583	DNA-binding transcription factor activity
F8M43_RS20065	COG1380	Effector of murein hydrolase LrgA
F8M43_RS20070	COG1346	cytolysis
F8M43_RS20075	COG2814	Major facilitator Superfamily
F8M43_RS20080	COG4895	conserved protein (DUF2196)
F8M43_RS20085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F8M43_RS20090	COG0346	lactoylglutathione lyase activity
F8M43_RS20095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M43_RS20100	COG1404	Belongs to the peptidase S8 family
F8M43_RS20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS20105	COG1263	PTS System
F8M43_RS20110	COG3711	transcriptional antiterminator
F8M43_RS20115	COG1442	glycosyl transferase family 8
F8M43_RS20120	COG5522	Integral membrane protein (intg_mem_TP0381)
F8M43_RS20125	COG1846	Transcriptional regulator
F8M43_RS20130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F8M43_RS20135	COG2234	aminopeptidase activity
F8M43_RS20155	COG2357	RelA SpoT domain protein
F8M43_RS20160	COG1575	Belongs to the MenA family. Type 1 subfamily
F8M43_RS20180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F8M43_RS20185	COG1696	Membrane protein involved in D-alanine export
F8M43_RS20190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F8M43_RS20195	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
F8M43_RS20200	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
F8M43_RS20205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F8M43_RS20210	COG1486	melibiose metabolic process
F8M43_RS20215	COG1447	Phosphotransferase system cellobiose-specific component IIA
F8M43_RS20220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M43_RS20225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
F8M43_RS20230	COG3711	transcriptional antiterminator
F8M43_RS20230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F8M43_RS20240	COG2094	Belongs to the DNA glycosylase MPG family
F8M43_RS20245	COG0753	catalase activity
F8M43_RS20255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
F8M43_RS20260	COG1131	(ABC) transporter
F8M43_RS20280	COG1595	DNA-templated transcription, initiation
F8M43_RS20285	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
F8M43_RS20290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F8M43_RS20295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F8M43_RS20300	COG4988	ABC transporter
F8M43_RS20305	COG1294	oxidase, subunit
F8M43_RS20310	COG1271	oxidase subunit
F8M43_RS20315	COG3493	citrate carrier protein
F8M43_RS20320	COG0501	Belongs to the peptidase M48B family
F8M43_RS20330	COG0726	polysaccharide deacetylase
F8M43_RS20335	COG3842	ATPase activity
F8M43_RS20340	COG2508	Transcriptional regulator
F8M43_RS20345	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS20350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
F8M43_RS20360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F8M43_RS20365	COG1881	PFAM PEBP family protein
F8M43_RS20370	COG0583	DNA-binding transcription factor activity
F8M43_RS20380	COG4585	Histidine kinase
F8M43_RS20385	COG2197	response regulator
F8M43_RS20390	COG2195	Cleaves the N-terminal amino acid of tripeptides
F8M43_RS20400	COG4894	glucomannan catabolic process
F8M43_RS20405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M43_RS20410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F8M43_RS20415	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS20420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F8M43_RS20425	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F8M43_RS20430	COG2610	gluconate transmembrane transporter activity
F8M43_RS20435	COG0500	methyltransferase
F8M43_RS20440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F8M43_RS20455	COG0693	protein deglycase activity
F8M43_RS20455	COG0753	catalase activity
F8M43_RS20460	COG2851	Citrate transporter
F8M43_RS20465	COG2273	Hydrolase Family 16
F8M43_RS20470	COG3711	transcriptional antiterminator
F8M43_RS20480	COG2270	Major facilitator Superfamily
F8M43_RS20485	COG0513	Belongs to the DEAD box helicase family
F8M43_RS20490	COG3401	FG-GAP repeat protein
F8M43_RS20490	COG2755	lipolytic protein G-D-S-L family
F8M43_RS20540	COG3209	COG3209 Rhs family protein
F8M43_RS20545	COG0697	spore germination
F8M43_RS20555	COG0789	Transcriptional regulator
F8M43_RS20575	COG0589	response to stress
F8M43_RS20580	COG2723	6-phospho-beta-galactosidase activity
F8M43_RS20585	COG2190	(PTS) system
F8M43_RS20585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS20585	COG1263	PTS System
F8M43_RS20635	COG3507	Belongs to the glycosyl hydrolase 43 family
F8M43_RS20650	COG2986	histidine ammonia-lyase
F8M43_RS20655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F8M43_RS20660	COG1228	amidohydrolase
F8M43_RS20665	COG0010	Belongs to the arginase family
F8M43_RS20670	COG0833	amino acid
F8M43_RS20675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
F8M43_RS20680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
F8M43_RS20685	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F8M43_RS20690	COG2390	Transcriptional regulator
F8M43_RS20700	COG3192	ethanolamine utilization protein
F8M43_RS20705	COG2079	MmgE PrpD family protein
F8M43_RS20710	COG1473	amidohydrolase
F8M43_RS20715	COG1126	abc transporter atp-binding protein
F8M43_RS20720	COG0765	amino acid transport
F8M43_RS20725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F8M43_RS20730	COG0456	acetyltransferase
F8M43_RS20735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F8M43_RS20745	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F8M43_RS20750	COG0561	phosphatase activity
F8M43_RS20780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F8M43_RS20785	COG5294	Protein conserved in bacteria
F8M43_RS20790	COG0577	efflux transmembrane transporter activity
F8M43_RS20795	COG1136	(ABC) transporter
F8M43_RS20800	COG2205	protein histidine kinase activity
F8M43_RS20805	COG0745	RESPONSE REGULATOR receiver
F8M43_RS20810	COG0191	fructose-bisphosphate aldolase activity
F8M43_RS20815	COG1082	Xylose isomerase domain protein TIM barrel
F8M43_RS20820	COG1082	Xylose isomerase domain protein TIM barrel
F8M43_RS20825	COG0673	inositol 2-dehydrogenase activity
F8M43_RS20830	COG2814	Major facilitator Superfamily
F8M43_RS20835	COG1082	Xylose isomerase domain protein TIM barrel
F8M43_RS20840	COG3962	Belongs to the TPP enzyme family
F8M43_RS20845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F8M43_RS20855	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS20860	COG1349	DNA-binding transcription factor activity
F8M43_RS20865	COG0667	Aldo Keto reductase
F8M43_RS20880	COG2814	Major facilitator Superfamily
F8M43_RS20885	COG0326	Molecular chaperone. Has ATPase activity
F8M43_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS20900	COG1309	transcriptional regulator
F8M43_RS20905	COG1012	belongs to the aldehyde dehydrogenase family
F8M43_RS20915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F8M43_RS20925	COG1714	RDD family
F8M43_RS20930	COG2311	Membrane
F8M43_RS20935	COG1917	Cupin 2, conserved barrel domain protein
F8M43_RS20940	COG1309	transcriptional regulator
F8M43_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
F8M43_RS20950	COG1846	Transcriptional regulator
F8M43_RS20955	COG1380	Effector of murein hydrolase LrgA
F8M43_RS20960	COG1346	cytolysis
F8M43_RS20965	COG5039	Polysaccharide pyruvyl transferase
F8M43_RS20970	COG1929	Belongs to the glycerate kinase type-1 family
F8M43_RS20975	COG1802	Transcriptional regulator
F8M43_RS20980	COG1070	Carbohydrate kinase
F8M43_RS20985	COG2610	gluconate transmembrane transporter activity
F8M43_RS20990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
F8M43_RS20995	COG0450	alkyl hydroperoxide reductase
F8M43_RS21000	COG3634	alkyl hydroperoxide reductase activity
F8M43_RS21010	COG2723	6-phospho-beta-galactosidase activity
F8M43_RS21015	COG2190	(PTS) system
F8M43_RS21020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F8M43_RS21020	COG1263	PTS System
F8M43_RS21020	COG2190	(PTS) system
F8M43_RS21025	COG2188	Transcriptional regulator
F8M43_RS21035	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
F8M43_RS21070	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F8M43_RS21085	COG1063	alcohol dehydrogenase
F8M43_RS21105	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
F8M43_RS21110	COG0456	acetyltransferase
F8M43_RS21115	COG0457	Tetratricopeptide repeat
F8M43_RS21125	COG0010	Belongs to the arginase family
F8M43_RS21130	COG0833	amino acid
F8M43_RS21135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F8M43_RS21140	COG3829	transcription factor binding
F8M43_RS21145	COG5002	protein histidine kinase activity
F8M43_RS21150	COG0745	RESPONSE REGULATOR receiver
F8M43_RS21170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F8M43_RS21175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F8M43_RS21180	COG4853	Protein conserved in bacteria
F8M43_RS21185	COG4863	YycH protein
F8M43_RS21190	COG5002	protein histidine kinase activity
F8M43_RS21195	COG0745	RESPONSE REGULATOR receiver
F8M43_RS21225	COG0346	lactoylglutathione lyase activity
F8M43_RS21230	COG0305	Participates in initiation and elongation during chromosome replication
F8M43_RS21245	COG3093	addiction module antidote protein HigA
F8M43_RS21250	COG2807	transmembrane transport
F8M43_RS21255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F8M43_RS21260	COG0359	binds to the 23S rRNA
F8M43_RS21265	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
F8M43_RS21270	COG4241	membrane
F8M43_RS21280	COG5577	PFAM Coat F domain
F8M43_RS21285	COG1733	regulation of RNA biosynthetic process
F8M43_RS21290	COG1227	inorganic diphosphatase activity
F8M43_RS21300	COG2271	Major facilitator Superfamily
F8M43_RS21305	COG0789	Transcriptional regulator
F8M43_RS21305	COG4978	Transcriptional regulator
F8M43_RS21315	COG4319	ketosteroid isomerase
F8M43_RS21320	COG1357	PFAM Pentapeptide repeats (8 copies)
F8M43_RS21325	COG2814	Major facilitator Superfamily
F8M43_RS21330	COG0583	DNA-binding transcription factor activity
F8M43_RS21335	COG2153	protein acetylation
F8M43_RS21350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F8M43_RS21355	COG1846	Transcriptional regulator
F8M43_RS21360	COG2153	protein acetylation
F8M43_RS21365	COG2364	Membrane
F8M43_RS21370	COG0456	acetyltransferase
F8M43_RS21375	COG2315	Protein conserved in bacteria
F8M43_RS21380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
F8M43_RS21390	COG2814	Major facilitator Superfamily
F8M43_RS21400	COG1331	Highly conserved protein containing a thioredoxin domain
F8M43_RS21405	COG1266	CAAX protease self-immunity
F8M43_RS21410	COG0477	Major facilitator Superfamily
F8M43_RS21410	COG2814	Major facilitator Superfamily
F8M43_RS21415	COG0110	maltose O-acetyltransferase activity
F8M43_RS21420	COG0346	lactoylglutathione lyase activity
F8M43_RS21425	COG1609	Transcriptional regulator
F8M43_RS21430	COG0708	Exodeoxyribonuclease III
F8M43_RS21435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F8M43_RS21440	COG0629	single-stranded DNA binding
F8M43_RS21445	COG0360	Binds together with S18 to 16S ribosomal RNA
F8M43_RS21450	COG0012	GTP binding
F8M43_RS21455	COG0243	molybdopterin cofactor binding
F8M43_RS21460	COG4481	Protein conserved in bacteria
F8M43_RS21465	COG3949	Membrane
F8M43_RS21475	COG1475	DNA binding
F8M43_RS21480	COG1192	Involved in chromosome partitioning
F8M43_RS21490	COG1475	DNA binding
F8M43_RS21495	COG0357	Ribosomal RNA small subunit methyltransferase G
F8M43_RS21500	COG0445	tRNA wobble uridine modification
F8M43_RS21505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F8M43_RS21510	COG1847	R3H domain protein
F8M43_RS21515	COG0706	membrane insertase activity
F8M43_RS21520	COG0594	ribonuclease P activity