locus-tag	class	description
SD85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SD85_RS00010	COG0592	DNA-directed DNA polymerase activity
SD85_RS00015	COG2501	S4 domain
SD85_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SD85_RS00030	COG0187	DNA topoisomerase II activity
SD85_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD85_RS00070	COG0517	IMP dehydrogenase activity
SD85_RS00070	COG0516	GMP reductase activity
SD85_RS00075	COG1686	Belongs to the peptidase S11 family
SD85_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SD85_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SD85_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SD85_RS00100	COG1428	Deoxynucleoside kinase
SD85_RS00105	COG1428	Deoxynucleoside kinase
SD85_RS00110	COG3858	chitin binding
SD85_RS00110	COG1388	LysM domain
SD85_RS00115	COG1335	isochorismatase
SD85_RS00120	COG0590	tRNA wobble adenosine to inosine editing
SD85_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SD85_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SD85_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SD85_RS00180	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
SD85_RS00185	COG3853	Toxic anion resistance protein (TelA)
SD85_RS00190	COG1982	Orn Lys Arg decarboxylase major
SD85_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SD85_RS00200	COG3870	Protein conserved in bacteria
SD85_RS00205	COG1728	Protein conserved in bacteria
SD85_RS00210	COG0470	DNA polymerase III
SD85_RS00215	COG1774	PSP1 C-terminal conserved region
SD85_RS00220	COG4467	Involved in initiation control of chromosome replication
SD85_RS00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SD85_RS00230	COG2827	Endonuclease containing a URI domain
SD85_RS00235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SD85_RS00240	COG2002	toxin-antitoxin pair type II binding
SD85_RS00245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD85_RS00245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD85_RS00250	COG0084	hydrolase, TatD family'
SD85_RS00255	COG3584	3D domain protein
SD85_RS00255	COG3583	domain protein
SD85_RS00260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SD85_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SD85_RS00275	COG4466	Protein conserved in bacteria
SD85_RS00285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SD85_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SD85_RS00295	COG0251	oxidation-reduction process
SD85_RS00300	COG2088	sporulation resulting in formation of a cellular spore
SD85_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SD85_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SD85_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SD85_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
SD85_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SD85_RS00340	COG2002	toxin-antitoxin pair type II binding
SD85_RS00345	COG2244	polysaccharide biosynthetic process
SD85_RS00350	COG3956	TIGRFAM MazG family protein
SD85_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SD85_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
SD85_RS00375	COG1098	S1 RNA binding domain
SD85_RS00390	COG2208	phosphoserine phosphatase activity
SD85_RS00395	COG2304	oxidoreductase activity
SD85_RS00400	COG0515	serine threonine protein kinase
SD85_RS00405	COG0037	tRNA processing
SD85_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SD85_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD85_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SD85_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SD85_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SD85_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD85_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD85_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
SD85_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD85_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SD85_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SD85_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SD85_RS00470	COG1396	sequence-specific DNA binding
SD85_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SD85_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SD85_RS00505	COG4463	regulation of RNA biosynthetic process
SD85_RS00510	COG3880	PFAM UvrB UvrC protein
SD85_RS00515	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SD85_RS00520	COG0542	response to heat
SD85_RS00525	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SD85_RS00530	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SD85_RS00535	COG4956	integral membrane protein (PIN domain superfamily)
SD85_RS00540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SD85_RS00545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SD85_RS00550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SD85_RS00560	COG1045	serine acetyltransferase
SD85_RS00565	COG0215	cysteine-tRNA ligase activity
SD85_RS00570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SD85_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD85_RS00580	COG3688	RNA-binding protein containing a PIN domain
SD85_RS00585	COG1595	DNA-templated transcription, initiation
SD85_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SD85_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
SD85_RS00610	COG0081	regulation of translation
SD85_RS00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SD85_RS00625	COG2813	Specifically methylates the guanine in position
SD85_RS00630	COG0085	RNA polymerase activity
SD85_RS00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SD85_RS00640	COG1358	cellular component organization or biogenesis
SD85_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SD85_RS00650	COG0049	tRNA binding
SD85_RS00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SD85_RS00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SD85_RS00665	COG0596	Alpha beta hydrolase
SD85_RS00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SD85_RS00680	COG0088	Forms part of the polypeptide exit tunnel
SD85_RS00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SD85_RS00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SD85_RS00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SD85_RS00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SD85_RS00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SD85_RS00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SD85_RS00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SD85_RS00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SD85_RS00770	COG0200	Binds to the 23S rRNA
SD85_RS00775	COG0201	protein transport
SD85_RS00780	COG0563	adenylate kinase activity
SD85_RS00785	COG0024	Methionine aminopeptidase
SD85_RS00790	COG2163	COG2163 Ribosomal protein L14E L6E L27E
SD85_RS00800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SD85_RS00810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SD85_RS00815	COG0202	RNA polymerase activity
SD85_RS00820	COG0203	ribosomal protein L17
SD85_RS00825	COG1122	ATPase activity
SD85_RS00830	COG1122	ATPase activity
SD85_RS00835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SD85_RS00840	COG0101	tRNA pseudouridine synthase activity
SD85_RS00860	COG2226	methyltransferase
SD85_RS00870	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS00875	COG0489	protein tyrosine kinase activity
SD85_RS00885	COG2194	sulfuric ester hydrolase activity
SD85_RS00890	COG0726	polysaccharide deacetylase
SD85_RS00960	COG0659	secondary active sulfate transmembrane transporter activity
SD85_RS00965	COG0385	Bile acid
SD85_RS00970	COG2819	hydrolase of the alpha beta superfamily
SD85_RS00975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS00980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS00985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS00990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS00990	COG2207	Transcriptional regulator
SD85_RS00995	COG3876	Protein conserved in bacteria
SD85_RS01000	COG1472	Belongs to the glycosyl hydrolase 3 family
SD85_RS01005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD85_RS01010	COG1263	PTS System
SD85_RS01010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS01015	COG1737	Transcriptional regulator
SD85_RS01020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SD85_RS01025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS01030	COG1683	Conserved Protein
SD85_RS01060	COG1595	DNA-templated transcription, initiation
SD85_RS01065	COG5662	AntiSigma factor
SD85_RS01070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SD85_RS01075	COG4856	YbbR-like protein
SD85_RS01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD85_RS01090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SD85_RS01095	COG3002	Belongs to the UPF0753 family
SD85_RS01110	COG5609	conserved protein (DUF2294)
SD85_RS01115	COG0596	Alpha beta hydrolase
SD85_RS01120	COG0745	RESPONSE REGULATOR receiver
SD85_RS01125	COG0642	Histidine kinase
SD85_RS01135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SD85_RS01145	COG2211	Major facilitator Superfamily
SD85_RS01155	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
SD85_RS01155	COG0028	Belongs to the TPP enzyme family
SD85_RS01205	COG0515	serine threonine protein kinase
SD85_RS01220	COG1113	amino acid transport
SD85_RS01235	COG2602	Beta-lactamase
SD85_RS01240	COG2124	cytochrome p450
SD85_RS01250	COG1283	sodium-dependent phosphate transmembrane transporter activity
SD85_RS01255	COG0584	glycerophosphoryl diester phosphodiesterase
SD85_RS01260	COG2271	Major facilitator Superfamily
SD85_RS01270	COG1846	Transcriptional regulator
SD85_RS01270	COG0456	acetyltransferase
SD85_RS01275	COG2271	Major facilitator Superfamily
SD85_RS01290	COG0697	spore germination
SD85_RS01295	COG2207	Transcriptional regulator
SD85_RS01295	COG1917	Cupin 2, conserved barrel domain protein
SD85_RS01300	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SD85_RS01305	COG3591	Belongs to the peptidase S1B family
SD85_RS01315	COG0596	Alpha beta hydrolase
SD85_RS01320	COG1183	phosphatidylcholine synthase activity
SD85_RS01325	COG0586	Pfam SNARE associated Golgi protein
SD85_RS01330	COG0688	phosphatidylethanolamine metabolic process
SD85_RS01340	COG2312	Erythromycin esterase
SD85_RS01345	COG1054	Belongs to the UPF0176 family
SD85_RS01350	COG1301	dicarboxylic acid transport
SD85_RS01360	COG0363	glucosamine-6-phosphate deaminase activity
SD85_RS01365	COG2188	Transcriptional regulator
SD85_RS01375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD85_RS01380	COG0833	amino acid
SD85_RS01385	COG2040	homocysteine
SD85_RS01395	COG1115	amino acid carrier protein
SD85_RS01400	COG2066	Belongs to the glutaminase family
SD85_RS01405	COG4191	Histidine kinase
SD85_RS01410	COG0784	Response regulator, receiver
SD85_RS01415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD85_RS01420	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS01425	COG2271	Major facilitator Superfamily
SD85_RS01430	COG4948	Mandelate Racemase Muconate Lactonizing
SD85_RS01435	COG2186	Transcriptional regulator
SD85_RS01440	COG2721	sulfolactate sulfo-lyase activity
SD85_RS01445	COG3173	Aminoglycoside phosphotransferase
SD85_RS01455	COG0745	RESPONSE REGULATOR receiver
SD85_RS01460	COG2205	protein histidine kinase activity
SD85_RS01465	COG1131	(ABC) transporter
SD85_RS01485	COG3773	Cell wall hydrolase
SD85_RS01490	COG2304	oxidoreductase activity
SD85_RS01500	COG3540	Alkaline phosphatase
SD85_RS01505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD85_RS01510	COG0805	protein transport
SD85_RS01515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SD85_RS01520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SD85_RS01525	COG0477	Major facilitator Superfamily
SD85_RS01530	COG1309	transcriptional regulator
SD85_RS01535	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SD85_RS01540	COG1714	RDD family
SD85_RS01545	COG3012	SEC-C Motif Domain Protein
SD85_RS01545	COG1405	negative regulation of cell septum assembly
SD85_RS01550	COG3290	protein histidine kinase activity
SD85_RS01555	COG1668	transmembrane transport
SD85_RS01560	COG0667	Aldo Keto reductase
SD85_RS01570	COG1595	DNA-templated transcription, initiation
SD85_RS01575	COG1595	DNA-templated transcription, initiation
SD85_RS01585	COG2801	Transposase and inactivated derivatives
SD85_RS01590	COG1595	DNA-templated transcription, initiation
SD85_RS01595	COG1876	peptidase activity
SD85_RS01600	COG0457	Tetratricopeptide repeat
SD85_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS01610	COG0366	Alpha amylase catalytic
SD85_RS01615	COG0803	Belongs to the bacterial solute-binding protein 9 family
SD85_RS01620	COG1121	(ABC) transporter
SD85_RS01625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD85_RS01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD85_RS01635	COG2310	stress, protein
SD85_RS01640	COG2310	stress, protein
SD85_RS01645	COG2310	stress, protein
SD85_RS01650	COG0861	Integral membrane protein TerC family
SD85_RS01660	COG3853	Toxic anion resistance protein (TelA)
SD85_RS01665	COG0477	Major facilitator Superfamily
SD85_RS01670	COG0640	Transcriptional regulator
SD85_RS01675	COG0517	IMP dehydrogenase activity
SD85_RS01675	COG4175	Glycine betaine
SD85_RS01680	COG4176	ABC-type proline glycine betaine transport system permease component
SD85_RS01685	COG2113	Glycine betaine
SD85_RS01690	COG1473	amidohydrolase
SD85_RS01695	COG1288	antiporter activity
SD85_RS01710	COG0366	Alpha amylase catalytic
SD85_RS01715	COG0039	L-malate dehydrogenase activity
SD85_RS01720	COG1620	l-lactate permease
SD85_RS01725	COG2814	Major facilitator Superfamily
SD85_RS01730	COG1846	Transcriptional regulator
SD85_RS01735	COG1280	lysine exporter protein (LysE YggA)
SD85_RS01740	COG3403	YqcI/YcgG family
SD85_RS01745	COG1113	amino acid transport
SD85_RS01750	COG3665	Urea carboxylase-associated protein
SD85_RS01755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SD85_RS01760	COG1660	Displays ATPase and GTPase activities
SD85_RS01765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SD85_RS01770	COG2226	methyltransferase
SD85_RS01775	COG0583	DNA-binding transcription factor activity
SD85_RS01780	COG3458	cephalosporin-C deacetylase activity
SD85_RS01785	COG3541	Predicted nucleotidyltransferase
SD85_RS01790	COG0506	proline dehydrogenase activity
SD85_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS01800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS01805	COG2508	Transcriptional regulator
SD85_RS01810	COG3689	TIGRFAM TIGR03943 family protein
SD85_RS01815	COG0701	Predicted permease
SD85_RS01820	COG2267	carboxylic ester hydrolase activity
SD85_RS01825	COG0492	ferredoxin-NADP+ reductase activity
SD85_RS01830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD85_RS01830	COG1587	Uroporphyrinogen-III synthase
SD85_RS01835	COG2146	nitrite reductase [NAD(P)H] activity
SD85_RS01840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD85_RS01845	COG0243	molybdopterin cofactor binding
SD85_RS01850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD85_RS01855	COG2223	nitrite transmembrane transporter activity
SD85_RS01860	COG1469	GTP cyclohydrolase I activity
SD85_RS01865	COG1376	ErfK ybiS ycfS ynhG family protein
SD85_RS01865	COG1376	ErfK ybiS ycfS ynhG family protein
SD85_RS01875	COG0523	cobalamin synthesis protein
SD85_RS01880	COG0765	amino acid transport
SD85_RS01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD85_RS01895	COG1714	RDD family
SD85_RS01905	COG1846	Transcriptional regulator
SD85_RS01915	COG3842	ATPase activity
SD85_RS01920	COG2723	6-phospho-beta-galactosidase activity
SD85_RS01930	COG3209	COG3209 Rhs family protein
SD85_RS01935	COG0840	transmembrane signaling receptor activity
SD85_RS01935	COG3290	protein histidine kinase activity
SD85_RS01940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SD85_RS01945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SD85_RS01950	COG1733	regulation of RNA biosynthetic process
SD85_RS01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS01975	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SD85_RS01980	COG2814	Major facilitator Superfamily
SD85_RS01990	COG0697	spore germination
SD85_RS01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS02005	COG2364	Membrane
SD85_RS02010	COG1126	abc transporter atp-binding protein
SD85_RS02015	COG0765	amino acid transport
SD85_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD85_RS02025	COG0583	DNA-binding transcription factor activity
SD85_RS02030	COG0163	prenyltransferase activity
SD85_RS02035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SD85_RS02050	COG0596	Alpha beta hydrolase
SD85_RS02055	COG3104	oligopeptide transport
SD85_RS02060	COG5434	Belongs to the glycosyl hydrolase 28 family
SD85_RS02070	COG0697	spore germination
SD85_RS02080	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SD85_RS02085	COG1136	(ABC) transporter
SD85_RS02090	COG0577	efflux transmembrane transporter activity
SD85_RS02095	COG0745	RESPONSE REGULATOR receiver
SD85_RS02100	COG3850	Histidine kinase
SD85_RS02100	COG5002	protein histidine kinase activity
SD85_RS02105	COG0457	Tetratricopeptide repeat
SD85_RS02120	COG0527	aspartate kinase activity
SD85_RS02125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS02130	COG4605	iron ion homeostasis
SD85_RS02135	COG4604	ABC transporter, ATP-binding protein
SD85_RS02140	COG4607	ABC-type enterochelin transport system periplasmic component
SD85_RS02145	COG2814	Major facilitator Superfamily
SD85_RS02150	COG1309	transcriptional regulator
SD85_RS02155	COG0778	Nitroreductase
SD85_RS02160	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SD85_RS02165	COG0640	Transcriptional regulator
SD85_RS02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS02175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SD85_RS02180	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS02185	COG4975	Glucose uptake
SD85_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS02195	COG4549	nuclear export factor GLE1
SD85_RS02200	COG1276	copper resistance
SD85_RS02200	COG2372	response to copper ion
SD85_RS02205	COG1349	DNA-binding transcription factor activity
SD85_RS02215	COG2213	PTS system mannitol-specific
SD85_RS02220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS02225	COG0246	Mannitol dehydrogenase
SD85_RS02230	COG0473	3-isopropylmalate dehydrogenase activity
SD85_RS02235	COG0681	Belongs to the peptidase S26 family
SD85_RS02240	COG0412	Dienelactone hydrolase
SD85_RS02245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SD85_RS02255	COG0561	phosphatase activity
SD85_RS02260	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SD85_RS02265	COG1914	H( )-stimulated, divalent metal cation uptake system
SD85_RS02270	COG4336	lyase activity
SD85_RS02275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SD85_RS02280	COG1984	allophanate hydrolase subunit 2
SD85_RS02285	COG1414	Transcriptional regulator
SD85_RS02290	COG2755	lipolytic protein G-D-S-L family
SD85_RS02300	COG2329	Antibiotic biosynthesis monooxygenase
SD85_RS02305	COG0768	penicillin binding
SD85_RS02310	COG4989	oxidoreductase activity
SD85_RS02315	COG3711	transcriptional antiterminator
SD85_RS02320	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS02325	COG2226	methyltransferase
SD85_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS02335	COG1917	Cupin 2, conserved barrel domain protein
SD85_RS02340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS02345	COG3871	stress protein (general stress protein 26)
SD85_RS02355	COG2814	Major facilitator Superfamily
SD85_RS02360	COG1522	sequence-specific DNA binding
SD85_RS02365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SD85_RS02365	COG0551	DNA topoisomerase type I activity
SD85_RS02370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SD85_RS02375	COG3706	GGDEF domain
SD85_RS02380	COG5298	Protein conserved in bacteria
SD85_RS02385	COG1215	transferase activity, transferring glycosyl groups
SD85_RS02395	COG0531	amino acid
SD85_RS02400	COG0494	nUDIX hydrolase
SD85_RS02405	COG0028	Belongs to the TPP enzyme family
SD85_RS02415	COG1914	H( )-stimulated, divalent metal cation uptake system
SD85_RS02420	COG2261	transglycosylase associated protein
SD85_RS02425	COG4876	unkown
SD85_RS02430	COG2217	Heavy metal translocating P-type atpase
SD85_RS02435	COG3729	General stress protein
SD85_RS02445	COG2329	Antibiotic biosynthesis monooxygenase
SD85_RS02450	COG3546	catalase activity
SD85_RS02455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SD85_RS02460	COG3290	protein histidine kinase activity
SD85_RS02465	COG4565	transcriptional regulatory protein
SD85_RS02470	COG1301	dicarboxylic acid transport
SD85_RS02475	COG0628	permease
SD85_RS02480	COG1301	dicarboxylic acid transport
SD85_RS02485	COG1131	(ABC) transporter
SD85_RS02490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SD85_RS02500	COG1960	acyl-CoA dehydrogenase activity
SD85_RS02515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SD85_RS02520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS02525	COG1181	Belongs to the D-alanine--D-alanine ligase family
SD85_RS02530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SD85_RS02535	COG0513	Belongs to the DEAD box helicase family
SD85_RS02540	COG3402	PFAM membrane-flanked domain
SD85_RS02545	COG3428	Bacterial PH domain
SD85_RS02550	COG0705	Rhomboid family
SD85_RS02555	COG0736	holo-[acyl-carrier-protein] synthase activity
SD85_RS02560	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SD85_RS02565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SD85_RS02570	COG0864	Transcriptional regulator
SD85_RS02575	COG2337	Toxic component of a toxin-antitoxin (TA) module
SD85_RS02580	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS02585	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS02590	COG2172	sigma factor antagonist activity
SD85_RS02595	COG2208	phosphoserine phosphatase activity
SD85_RS02600	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS02605	COG2172	sigma factor antagonist activity
SD85_RS02610	COG1191	sigma factor activity
SD85_RS02615	COG2208	phosphoserine phosphatase activity
SD85_RS02620	COG2183	response to ionizing radiation
SD85_RS02630	COG3091	SprT-like family
SD85_RS02675	COG0789	Transcriptional regulator
SD85_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS02685	COG0667	Aldo Keto reductase
SD85_RS02690	COG4221	oxidoreductase activity
SD85_RS02695	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS02705	COG4221	oxidoreductase activity
SD85_RS02710	COG3239	Fatty acid desaturase
SD85_RS02715	COG1278	Cold shock
SD85_RS02720	COG1329	Transcriptional regulator
SD85_RS02730	COG1396	sequence-specific DNA binding
SD85_RS02735	COG3708	Transcriptional regulator
SD85_RS02735	COG2207	Transcriptional regulator
SD85_RS02745	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
SD85_RS02760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SD85_RS02765	COG1522	sequence-specific DNA binding
SD85_RS02770	COG0697	spore germination
SD85_RS02775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS02780	COG2030	dehydratase
SD85_RS02785	COG3545	Serine hydrolase
SD85_RS02790	COG1733	regulation of RNA biosynthetic process
SD85_RS02795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS02805	COG0640	Transcriptional regulator
SD85_RS02810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SD85_RS02815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD85_RS02820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS02825	COG0697	spore germination
SD85_RS02830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS02835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SD85_RS02840	COG0640	Transcriptional regulator
SD85_RS02845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD85_RS02860	COG4585	Histidine kinase
SD85_RS02865	COG2197	response regulator
SD85_RS02870	COG2409	Drug exporters of the RND superfamily
SD85_RS02880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SD85_RS02885	COG1114	Component of the transport system for branched-chain amino acids
SD85_RS02895	COG1811	Na channel or pump
SD85_RS02900	COG0789	Transcriptional regulator
SD85_RS02900	COG4978	Transcriptional regulator
SD85_RS02905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SD85_RS02910	COG0778	Nitroreductase
SD85_RS02915	COG0346	lactoylglutathione lyase activity
SD85_RS02920	COG2259	Doxx family
SD85_RS02925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS02945	COG4122	O-methyltransferase activity
SD85_RS02950	COG2323	membrane
SD85_RS02955	COG0071	Belongs to the small heat shock protein (HSP20) family
SD85_RS02970	COG1309	transcriptional regulator
SD85_RS02980	COG0456	acetyltransferase
SD85_RS02990	COG0673	inositol 2-dehydrogenase activity
SD85_RS02995	COG1609	Transcriptional regulator
SD85_RS03000	COG2814	Major facilitator Superfamily
SD85_RS03005	COG2814	Major facilitator Superfamily
SD85_RS03010	COG2814	Major facilitator Superfamily
SD85_RS03015	COG1082	Xylose isomerase domain protein TIM barrel
SD85_RS03020	COG2814	Major facilitator Superfamily
SD85_RS03030	COG0488	(ABC) transporter
SD85_RS03035	COG1113	amino acid transport
SD85_RS03040	COG2318	DinB family
SD85_RS03045	COG1846	Transcriptional regulator
SD85_RS03050	COG2409	Drug exporters of the RND superfamily
SD85_RS03050	COG1033	growth of symbiont in host cell
SD85_RS03055	COG0778	Nitroreductase
SD85_RS03060	COG1846	Transcriptional regulator
SD85_RS03065	COG1396	sequence-specific DNA binding
SD85_RS03080	COG2814	Major facilitator Superfamily
SD85_RS03085	COG0730	response to heat
SD85_RS03090	COG1802	Transcriptional regulator
SD85_RS03095	COG1388	LysM domain
SD85_RS03095	COG3858	chitin binding
SD85_RS03100	COG1819	glycosyl
SD85_RS03115	COG1785	Belongs to the alkaline phosphatase family
SD85_RS03125	COG0454	-acetyltransferase
SD85_RS03130	COG1078	dGTPase activity
SD85_RS03135	COG1388	LysM domain
SD85_RS03140	COG2814	Major facilitator Superfamily
SD85_RS03145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SD85_RS03150	COG1447	Phosphotransferase system cellobiose-specific component IIA
SD85_RS03155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SD85_RS03160	COG2723	6-phospho-beta-galactosidase activity
SD85_RS03165	COG2188	Transcriptional regulator
SD85_RS03170	COG1940	carbohydrate kinase activity
SD85_RS03175	COG1482	cell wall glycoprotein biosynthetic process
SD85_RS03180	COG4124	Belongs to the glycosyl hydrolase 26 family
SD85_RS03225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SD85_RS03230	COG0802	atpase or kinase
SD85_RS03235	COG1214	PFAM Peptidase M22, glycoprotease
SD85_RS03240	COG0456	acetyltransferase
SD85_RS03245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SD85_RS03250	COG0488	(ABC) transporter
SD85_RS03255	COG0315	cyclic pyranopterin monophosphate synthase activity
SD85_RS03260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SD85_RS03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SD85_RS03270	COG0805	protein transport
SD85_RS03280	COG1266	CAAX protease self-immunity
SD85_RS03290	COG0459	protein refolding
SD85_RS03295	COG1073	alpha beta
SD85_RS03300	COG0457	Tetratricopeptide repeat
SD85_RS03305	COG1063	alcohol dehydrogenase
SD85_RS03310	COG2211	Major facilitator Superfamily
SD85_RS03315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD85_RS03320	COG1842	Phage shock protein A
SD85_RS03325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SD85_RS03330	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SD85_RS03335	COG4260	virion core protein, lumpy skin disease virus
SD85_RS03345	COG2814	Major facilitator Superfamily
SD85_RS03350	COG1063	alcohol dehydrogenase
SD85_RS03355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SD85_RS03360	COG0823	Involved in the tonB-independent uptake of proteins
SD85_RS03370	COG2801	Transposase and inactivated derivatives
SD85_RS03385	COG2267	carboxylic ester hydrolase activity
SD85_RS03395	COG2132	Multicopper oxidase
SD85_RS03400	COG1113	amino acid transport
SD85_RS03410	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SD85_RS03415	COG0714	Associated with various cellular activities
SD85_RS03420	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
SD85_RS03425	COG1305	Transglutaminase-like
SD85_RS03430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SD85_RS03430	COG0519	Catalyzes the synthesis of GMP from XMP
SD85_RS03435	COG2252	PERMEase
SD85_RS03440	COG3064	Membrane
SD85_RS03450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SD85_RS03460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SD85_RS03465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SD85_RS03470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SD85_RS03475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SD85_RS03480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SD85_RS03485	COG0047	phosphoribosylformylglycinamidine synthase activity
SD85_RS03490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SD85_RS03495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SD85_RS03500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SD85_RS03505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SD85_RS03510	COG0138	bifunctional purine biosynthesis protein purh
SD85_RS03515	COG0151	Belongs to the GarS family
SD85_RS03520	COG1522	sequence-specific DNA binding
SD85_RS03525	COG0531	amino acid
SD85_RS03535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD85_RS03540	COG1470	cell adhesion involved in biofilm formation
SD85_RS03545	COG4496	protein, YerC YecD
SD85_RS03550	COG0069	glutamate synthase activity
SD85_RS03555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SD85_RS03560	COG0210	DNA helicase
SD85_RS03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SD85_RS03570	COG4851	CamS sex pheromone cAM373 precursor
SD85_RS03580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SD85_RS03585	COG1285	pathogenesis
SD85_RS03590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS03595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SD85_RS03600	COG0154	amidase activity
SD85_RS03605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SD85_RS03610	COG1309	transcriptional regulator
SD85_RS03615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SD85_RS03620	COG1597	lipid kinase activity
SD85_RS03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SD85_RS03630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SD85_RS03635	COG0732	type I restriction modification DNA specificity domain
SD85_RS03640	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SD85_RS03660	COG5444	nuclease activity
SD85_RS03665	COG3391	amine dehydrogenase activity
SD85_RS03670	COG0457	Tetratricopeptide repeat
SD85_RS03680	COG0217	transcriptional regulatory protein
SD85_RS03690	COG1309	transcriptional regulator
SD85_RS03695	COG3631	Ketosteroid isomerase-related protein
SD85_RS03700	COG0702	epimerase
SD85_RS03705	COG2159	amidohydrolase
SD85_RS03710	COG1309	transcriptional regulator
SD85_RS03725	COG3546	catalase activity
SD85_RS03730	COG0454	-acetyltransferase
SD85_RS03740	COG5578	integral membrane protein
SD85_RS03745	COG2972	Histidine kinase
SD85_RS03750	COG4753	response regulator
SD85_RS03750	COG2207	Transcriptional regulator
SD85_RS03755	COG1653	transport
SD85_RS03760	COG1175	transmembrane transport
SD85_RS03765	COG0395	ABC-type sugar transport system, permease component
SD85_RS03770	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SD85_RS03775	COG2207	Transcriptional regulator
SD85_RS03780	COG2755	lipolytic protein G-D-S-L family
SD85_RS03790	COG5578	integral membrane protein
SD85_RS03795	COG3401	FG-GAP repeat protein
SD85_RS03800	COG3401	FG-GAP repeat protein
SD85_RS03805	COG2755	lipolytic protein G-D-S-L family
SD85_RS03810	COG1874	Beta-galactosidase
SD85_RS03820	COG1653	transport
SD85_RS03825	COG4209	transmembrane transport
SD85_RS03830	COG0395	ABC-type sugar transport system, permease component
SD85_RS03835	COG1486	melibiose metabolic process
SD85_RS03840	COG2323	membrane
SD85_RS03845	COG2329	Antibiotic biosynthesis monooxygenase
SD85_RS03850	COG0346	lactoylglutathione lyase activity
SD85_RS03860	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS03865	COG5583	Uncharacterized small protein (DUF2292)
SD85_RS03870	COG0670	Belongs to the BI1 family
SD85_RS03875	COG1846	Transcriptional regulator
SD85_RS03880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD85_RS03890	COG2124	cytochrome p450
SD85_RS03890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SD85_RS03895	COG1368	sulfuric ester hydrolase activity
SD85_RS03900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SD85_RS03905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD85_RS03910	COG1442	glycosyl transferase family 8
SD85_RS03915	COG1216	Glycosyl transferase, family 2
SD85_RS03920	COG1442	glycosyl transferase family 8
SD85_RS03925	COG2223	nitrite transmembrane transporter activity
SD85_RS03930	COG1011	Hydrolase
SD85_RS03935	COG0531	amino acid
SD85_RS03940	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS03945	COG0840	transmembrane signaling receptor activity
SD85_RS03950	COG0488	(ABC) transporter
SD85_RS03960	COG0789	Transcriptional regulator
SD85_RS03965	COG2814	Major facilitator Superfamily
SD85_RS03980	COG0488	(ABC) transporter
SD85_RS03985	COG0513	Belongs to the DEAD box helicase family
SD85_RS03990	COG0456	acetyltransferase
SD85_RS03995	COG2130	NADP-dependent
SD85_RS04000	COG1120	ATPase activity
SD85_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS04015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SD85_RS04030	COG3866	Pectate lyase
SD85_RS04035	COG0471	metal ion transport
SD85_RS04040	COG3290	protein histidine kinase activity
SD85_RS04045	COG4565	transcriptional regulatory protein
SD85_RS04050	COG3181	Tripartite tricarboxylate transporter family receptor
SD85_RS04055	COG2851	Citrate transporter
SD85_RS04060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS04065	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SD85_RS04070	COG1254	Belongs to the acylphosphatase family
SD85_RS04075	COG2258	MOSC domain
SD85_RS04095	COG0024	Methionine aminopeptidase
SD85_RS04100	COG1263	PTS System
SD85_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS04105	COG1368	sulfuric ester hydrolase activity
SD85_RS04115	COG1115	amino acid carrier protein
SD85_RS04120	COG0531	amino acid
SD85_RS04135	COG0697	spore germination
SD85_RS04140	COG1263	PTS System
SD85_RS04140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS04145	COG0366	Alpha amylase catalytic
SD85_RS04150	COG2188	Transcriptional regulator
SD85_RS04155	COG0778	Nitroreductase
SD85_RS04160	COG0737	Belongs to the 5'-nucleotidase family
SD85_RS04165	COG0693	protein deglycase activity
SD85_RS04170	COG2814	Major facilitator Superfamily
SD85_RS04175	COG4840	Belongs to the UPF0435 family
SD85_RS04180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD85_RS04185	COG4980	gas vesicle protein
SD85_RS04190	COG1295	ribonuclease BN
SD85_RS04200	COG0477	Major facilitator Superfamily
SD85_RS04210	COG0387	Pfam Sodium calcium exchanger
SD85_RS04220	COG0668	transmembrane transport
SD85_RS04225	COG0535	radical SAM domain protein
SD85_RS04235	COG0726	polysaccharide deacetylase
SD85_RS04240	COG2084	Dehydrogenase
SD85_RS04245	COG0598	Magnesium transport protein CorA
SD85_RS04250	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SD85_RS04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SD85_RS04265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SD85_RS04275	COG4637	Psort location Cytoplasmic, score
SD85_RS04285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SD85_RS04290	COG0022	dehydrogenase e1 component
SD85_RS04295	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD85_RS04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD85_RS04305	COG3284	Transcriptional regulator
SD85_RS04315	COG1742	UPF0060 membrane protein
SD85_RS04335	COG4842	Belongs to the WXG100 family
SD85_RS04340	COG1486	melibiose metabolic process
SD85_RS04345	COG1737	Transcriptional regulator
SD85_RS04350	COG1263	PTS System
SD85_RS04350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS04355	COG1132	(ABC) transporter
SD85_RS04360	COG1132	(ABC) transporter
SD85_RS04365	COG2259	Doxx family
SD85_RS04370	COG2514	catechol 2,3-dioxygenase activity
SD85_RS04375	COG4585	Histidine kinase
SD85_RS04380	COG2197	response regulator
SD85_RS04385	COG1131	(ABC) transporter
SD85_RS04390	COG1511	domain protein
SD85_RS04390	COG0842	Transport permease protein
SD85_RS04395	COG0842	Transport permease protein
SD85_RS04405	COG1695	Transcriptional regulator
SD85_RS04410	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SD85_RS04415	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SD85_RS04420	COG2318	DinB family
SD85_RS04425	COG2814	Major facilitator Superfamily
SD85_RS04430	COG1846	Transcriptional regulator
SD85_RS04435	COG0392	lysyltransferase activity
SD85_RS04435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SD85_RS04440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS04460	COG0778	Nitroreductase
SD85_RS04475	COG1090	epimerase
SD85_RS04480	COG2137	regulation of response to DNA damage stimulus
SD85_RS04495	COG2814	Major facilitator Superfamily
SD85_RS04510	COG3103	Sh3 type 3 domain protein
SD85_RS04515	COG5658	integral membrane protein
SD85_RS04520	COG0596	Alpha beta hydrolase
SD85_RS04525	COG0463	Glycosyl transferase, family 2
SD85_RS04530	COG4485	Bacterial membrane protein, YfhO
SD85_RS04535	COG1988	membrane-bound metal-dependent
SD85_RS04540	COG1194	a g-specific adenine glycosylase
SD85_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS04565	COG3557	Belongs to the UPF0374 family
SD85_RS04570	COG1132	(ABC) transporter
SD85_RS04575	COG4129	membrane
SD85_RS04580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD85_RS04585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SD85_RS04590	COG0735	belongs to the Fur family
SD85_RS04710	COG4326	sporulation control protein
SD85_RS04720	COG5577	PFAM Coat F domain
SD85_RS04725	COG3340	Belongs to the peptidase S51 family
SD85_RS04730	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SD85_RS04740	COG0753	catalase activity
SD85_RS04745	COG1116	anion transmembrane transporter activity
SD85_RS04750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SD85_RS04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD85_RS04760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD85_RS04770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SD85_RS04780	COG1476	TRANSCRIPTIONal
SD85_RS04790	COG3382	B3 4 domain protein
SD85_RS04795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SD85_RS04805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SD85_RS04810	COG0789	Transcriptional regulator
SD85_RS04815	COG1664	Polymer-forming cytoskeletal
SD85_RS04820	COG1664	Polymer-forming cytoskeletal
SD85_RS04825	COG2766	serine protein kinase
SD85_RS04830	COG2718	Belongs to the UPF0229 family
SD85_RS04835	COG1846	Transcriptional regulator
SD85_RS04840	COG1566	PFAM secretion protein HlyD family protein
SD85_RS04845	COG2814	Major facilitator Superfamily
SD85_RS04850	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD85_RS04865	COG1725	Transcriptional regulator
SD85_RS04870	COG1131	(ABC) transporter
SD85_RS04875	COG1131	(ABC) transporter
SD85_RS04885	COG1278	Cold shock
SD85_RS04890	COG1464	Belongs to the NlpA lipoprotein family
SD85_RS04895	COG3706	GGDEF domain
SD85_RS04900	COG1823	symporter activity
SD85_RS04920	COG5577	PFAM Coat F domain
SD85_RS04925	COG4085	toxin activity
SD85_RS04925	COG1525	nuclease
SD85_RS04925	COG0737	Belongs to the 5'-nucleotidase family
SD85_RS04930	COG3764	Sortase (surface protein transpeptidase)
SD85_RS04935	COG0564	pseudouridine synthase activity
SD85_RS04945	COG0517	IMP dehydrogenase activity
SD85_RS04950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SD85_RS04955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD85_RS04955	COG3153	acetyltransferase
SD85_RS04965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD85_RS04970	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SD85_RS04975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SD85_RS04980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SD85_RS04985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SD85_RS04990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SD85_RS04995	COG2203	Gaf domain
SD85_RS04995	COG4585	Histidine kinase
SD85_RS05000	COG2197	response regulator
SD85_RS05005	COG0431	NADPH-dependent FMN reductase
SD85_RS05020	COG0791	NLP P60 protein
SD85_RS05020	COG1388	LysM domain
SD85_RS05025	COG1959	2 iron, 2 sulfur cluster binding
SD85_RS05030	COG0668	transmembrane transport
SD85_RS05035	COG2719	SpoVR family
SD85_RS05040	COG1785	Belongs to the alkaline phosphatase family
SD85_RS05045	COG0791	NLP P60 protein
SD85_RS05045	COG1388	LysM domain
SD85_RS05050	COG0583	DNA-binding transcription factor activity
SD85_RS05055	COG0372	Belongs to the citrate synthase family
SD85_RS05060	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS05065	COG0531	amino acid
SD85_RS05070	COG0733	neurotransmitter:sodium symporter activity
SD85_RS05075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS05080	COG0456	acetyltransferase
SD85_RS05095	COG1595	DNA-templated transcription, initiation
SD85_RS05100	COG0667	Aldo Keto reductase
SD85_RS05105	COG0204	Acyl-transferase
SD85_RS05110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD85_RS05120	COG1253	flavin adenine dinucleotide binding
SD85_RS05125	COG0789	Transcriptional regulator
SD85_RS05130	COG0436	Aminotransferase
SD85_RS05135	COG1253	flavin adenine dinucleotide binding
SD85_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD85_RS05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SD85_RS05150	COG0584	glycerophosphoryl diester phosphodiesterase
SD85_RS05160	COG0668	transmembrane transport
SD85_RS05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SD85_RS05170	COG0726	polysaccharide deacetylase
SD85_RS05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD85_RS05180	COG1757	Na H antiporter
SD85_RS05185	COG0589	response to stress
SD85_RS05195	COG1132	(ABC) transporter
SD85_RS05200	COG1132	(ABC) transporter
SD85_RS05205	COG0702	epimerase
SD85_RS05225	COG0189	ligase activity
SD85_RS05230	COG0189	ligase activity
SD85_RS05235	COG4399	Belongs to the UPF0754 family
SD85_RS05240	COG3679	Belongs to the UPF0342 family
SD85_RS05245	COG4335	DNA alkylation repair
SD85_RS05250	COG0561	phosphatase activity
SD85_RS05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SD85_RS05260	COG0475	glutathione-regulated potassium exporter activity
SD85_RS05265	COG0490	domain, Protein
SD85_RS05275	COG1024	Enoyl-CoA hydratase
SD85_RS05285	COG4152	abc transporter atp-binding protein
SD85_RS05290	COG1668	transmembrane transport
SD85_RS05295	COG0420	3'-5' exonuclease activity
SD85_RS05300	COG4717	serine-type aminopeptidase activity
SD85_RS05305	COG3481	metal-dependent phosphohydrolase, HD sub domain
SD85_RS05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SD85_RS05340	COG1846	Transcriptional regulator
SD85_RS05345	COG4980	gas vesicle protein
SD85_RS05360	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SD85_RS05365	COG0537	adenosine 5'-monophosphoramidase activity
SD85_RS05370	COG1131	(ABC) transporter
SD85_RS05375	COG4473	ABC transporter
SD85_RS05385	COG1473	amidohydrolase
SD85_RS05390	COG3069	C4-dicarboxylate transmembrane transporter activity
SD85_RS05400	COG2329	Antibiotic biosynthesis monooxygenase
SD85_RS05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD85_RS05410	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SD85_RS05415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SD85_RS05420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SD85_RS05425	COG1309	transcriptional regulator
SD85_RS05430	COG1511	domain protein
SD85_RS05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SD85_RS05440	COG4377	Putative membrane peptidase family (DUF2324)
SD85_RS05450	COG1363	Peptidase, m42
SD85_RS05455	COG4405	Protein conserved in bacteria
SD85_RS05460	COG1301	dicarboxylic acid transport
SD85_RS05470	COG1234	tRNA 3'-trailer cleavage
SD85_RS05475	COG0095	Lipoate-protein ligase
SD85_RS05480	COG0702	epimerase
SD85_RS05485	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS05495	COG0501	Belongs to the peptidase M48B family
SD85_RS05505	COG0456	acetyltransferase
SD85_RS05510	COG0604	alcohol dehydrogenase
SD85_RS05515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SD85_RS05520	COG0406	alpha-ribazole phosphatase activity
SD85_RS05525	COG0183	Belongs to the thiolase family
SD85_RS05530	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS05535	COG1268	BioY protein
SD85_RS05540	COG0840	transmembrane signaling receptor activity
SD85_RS05545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD85_RS05545	COG0723	plastoquinol--plastocyanin reductase activity
SD85_RS05550	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS05560	COG4903	ComK protein
SD85_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS05575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS05590	COG0398	Pfam SNARE associated Golgi protein
SD85_RS05595	COG0681	Belongs to the peptidase S26 family
SD85_RS05600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SD85_RS05605	COG1846	Transcriptional regulator
SD85_RS05615	COG0738	Major facilitator superfamily
SD85_RS05620	COG0673	inositol 2-dehydrogenase activity
SD85_RS05625	COG0561	phosphatase activity
SD85_RS05630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD85_RS05635	COG1609	Transcriptional regulator
SD85_RS05640	COG3180	Ammonia monooxygenase
SD85_RS05645	COG0477	Major facilitator Superfamily
SD85_RS05645	COG2814	Major facilitator Superfamily
SD85_RS05650	COG4533	DNA binding
SD85_RS05660	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SD85_RS05665	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SD85_RS05670	COG1074	ATP-dependent DNA helicase activity
SD85_RS05675	COG0420	3'-5' exonuclease activity
SD85_RS05680	COG0419	ATPase involved in DNA repair
SD85_RS05685	COG1403	HNH endonuclease
SD85_RS05725	COG5337	Spore coat protein CotH
SD85_RS05730	COG0179	Fumarylacetoacetate (FAA) hydrolase
SD85_RS05740	COG1404	Belongs to the peptidase S8 family
SD85_RS05750	COG0367	asparagine synthase
SD85_RS05755	COG2318	DinB family
SD85_RS05760	COG1562	ergosterol biosynthetic process
SD85_RS05765	COG0534	Mate efflux family protein
SD85_RS05770	COG1917	Cupin 2, conserved barrel domain protein
SD85_RS05770	COG2207	Transcriptional regulator
SD85_RS05775	COG1609	Transcriptional regulator
SD85_RS05780	COG0673	inositol 2-dehydrogenase activity
SD85_RS05785	COG2318	DinB family
SD85_RS05790	COG1279	arginine transmembrane transporter activity
SD85_RS05795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SD85_RS05800	COG1357	PFAM Pentapeptide repeats (8 copies)
SD85_RS05805	COG2267	carboxylic ester hydrolase activity
SD85_RS05810	COG0529	Catalyzes the synthesis of activated sulfate
SD85_RS05815	COG2046	Belongs to the sulfate adenylyltransferase family
SD85_RS05820	COG0175	sulfate reduction
SD85_RS05825	COG2045	Belongs to the ComB family
SD85_RS05830	COG1809	phosphosulfolactate synthase activity
SD85_RS05835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS05840	COG4948	Mandelate Racemase Muconate Lactonizing
SD85_RS05845	COG2814	Major facilitator Superfamily
SD85_RS05850	COG0454	-acetyltransferase
SD85_RS05855	COG2153	protein acetylation
SD85_RS05860	COG0646	methionine synthase
SD85_RS05860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SD85_RS05865	COG1666	GTP binding
SD85_RS05870	COG2996	Protein conserved in bacteria
SD85_RS05880	COG1307	EDD domain protein, DegV family
SD85_RS05885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS05905	COG0561	phosphatase activity
SD85_RS05910	COG1073	alpha beta
SD85_RS05915	COG2151	metal-sulfur cluster biosynthetic enzyme
SD85_RS05925	COG0277	FAD linked oxidase domain protein
SD85_RS05930	COG2271	Major facilitator Superfamily
SD85_RS05935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SD85_RS05940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SD85_RS05950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD85_RS05955	COG0505	Belongs to the CarA family
SD85_RS05960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD85_RS05965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SD85_RS05980	COG2267	carboxylic ester hydrolase activity
SD85_RS05990	COG1744	ABC transporter substrate-binding protein PnrA-like
SD85_RS06005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SD85_RS06010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD85_RS06015	COG5504	Zn-dependent protease
SD85_RS06020	COG0444	Belongs to the ABC transporter superfamily
SD85_RS06025	COG4608	Belongs to the ABC transporter superfamily
SD85_RS06035	COG0601	transmembrane transport
SD85_RS06040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD85_RS06050	COG0180	Tryptophanyl-tRNA synthetase
SD85_RS06055	COG4166	transmembrane transport
SD85_RS06060	COG0601	transmembrane transport
SD85_RS06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD85_RS06070	COG0444	Belongs to the ABC transporter superfamily
SD85_RS06075	COG4608	Belongs to the ABC transporter superfamily
SD85_RS06080	COG2814	Major facilitator Superfamily
SD85_RS06085	COG0456	acetyltransferase
SD85_RS06090	COG1393	Belongs to the ArsC family
SD85_RS06095	COG0861	Integral membrane protein TerC family
SD85_RS06100	COG4862	establishment of competence for transformation
SD85_RS06105	COG4469	Competence protein
SD85_RS06110	COG1164	Oligoendopeptidase f
SD85_RS06125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD85_RS06130	COG2346	COG2346, Truncated hemoglobins
SD85_RS06135	COG0741	lytic transglycosylase activity
SD85_RS06140	COG4116	CYTH
SD85_RS06150	COG2357	RelA SpoT domain protein
SD85_RS06155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SD85_RS06160	COG0564	pseudouridine synthase activity
SD85_RS06165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SD85_RS06170	COG0569	domain protein
SD85_RS06170	COG0475	glutathione-regulated potassium exporter activity
SD85_RS06175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SD85_RS06180	COG0352	thiamine-phosphate diphosphorylase activity
SD85_RS06185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD85_RS06190	COG2104	thiamine diphosphate biosynthetic process
SD85_RS06195	COG2022	thiamine diphosphate biosynthetic process
SD85_RS06200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SD85_RS06205	COG0351	phosphomethylpyrimidine kinase
SD85_RS06210	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SD85_RS06270	COG0210	DNA helicase
SD85_RS06280	COG2153	protein acetylation
SD85_RS06285	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SD85_RS06290	COG2382	esterase
SD85_RS06295	COG0626	cystathionine gamma-synthase activity
SD85_RS06300	COG0626	cystathionine gamma-synthase activity
SD85_RS06310	COG5505	Protein of unknown function (DUF819)
SD85_RS06320	COG5632	N-Acetylmuramoyl-L-alanine amidase
SD85_RS06320	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS06335	COG0457	Tetratricopeptide repeat
SD85_RS06365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS06365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SD85_RS06365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SD85_RS06370	COG1482	cell wall glycoprotein biosynthetic process
SD85_RS06390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SD85_RS06410	COG0109	protoheme IX farnesyltransferase activity
SD85_RS06420	COG0726	polysaccharide deacetylase
SD85_RS06440	COG5504	Zn-dependent protease
SD85_RS06445	COG2205	protein histidine kinase activity
SD85_RS06455	COG3383	formate dehydrogenase (NAD+) activity
SD85_RS06460	COG2427	Protein of unknown function (DUF1641)
SD85_RS06470	COG1051	belongs to the nudix hydrolase family
SD85_RS06480	COG2124	cytochrome p450
SD85_RS06485	COG1819	glycosyl
SD85_RS06495	COG1587	Uroporphyrinogen-III synthase
SD85_RS06500	COG0390	transport system, permease component
SD85_RS06505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SD85_RS06510	COG0697	spore germination
SD85_RS06515	COG4297	protein containing double-stranded beta helix domain
SD85_RS06525	COG1252	NADH dehydrogenase
SD85_RS06530	COG1904	glucuronate isomerase
SD85_RS06535	COG2211	Major facilitator Superfamily
SD85_RS06540	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SD85_RS06545	COG1063	alcohol dehydrogenase
SD85_RS06550	COG1312	Catalyzes the dehydration of D-mannonate
SD85_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS06560	COG2271	Major facilitator Superfamily
SD85_RS06565	COG1609	Transcriptional regulator
SD85_RS06570	COG0246	Mannitol dehydrogenase
SD85_RS06575	COG2721	sulfolactate sulfo-lyase activity
SD85_RS06580	COG0730	response to heat
SD85_RS06585	COG2318	DinB family
SD85_RS06590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SD85_RS06595	COG0457	Tetratricopeptide repeat
SD85_RS06605	COG2350	Protein conserved in bacteria
SD85_RS06610	COG1388	LysM domain
SD85_RS06610	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS06610	COG5632	N-Acetylmuramoyl-L-alanine amidase
SD85_RS06620	COG4195	phage-related replication protein
SD85_RS06625	COG3546	catalase activity
SD85_RS06630	COG2856	Zn peptidase
SD85_RS06635	COG1396	sequence-specific DNA binding
SD85_RS06645	COG1522	sequence-specific DNA binding
SD85_RS06650	COG1484	DNA-dependent DNA replication
SD85_RS06675	COG1595	DNA-templated transcription, initiation
SD85_RS06680	COG5484	DNA packaging
SD85_RS06680	COG3728	DNA packaging
SD85_RS06685	COG1783	phage Terminase large subunit
SD85_RS06690	COG5518	Phage portal protein
SD85_RS06695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SD85_RS06700	COG4653	Phage capsid family
SD85_RS06750	COG3953	SLT domain
SD85_RS06750	COG5412	phage tail tape measure protein
SD85_RS06750	COG3953	SLT domain
SD85_RS06750	COG5412	phage tail tape measure protein
SD85_RS06750	COG5412	phage tail tape measure protein
SD85_RS06750	COG3953	SLT domain
SD85_RS06755	COG1652	LysM domain
SD85_RS06760	COG4193	domain, Protein
SD85_RS06770	COG3628	GPW Gp25 family protein
SD85_RS06775	COG3299	homolog of phage Mu protein gp47
SD85_RS06780	COG3778	Protein conserved in bacteria
SD85_RS06820	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS06820	COG5632	N-Acetylmuramoyl-L-alanine amidase
SD85_RS06835	COG0306	phosphate transporter
SD85_RS06840	COG1392	Phosphate transport regulator
SD85_RS06845	COG0531	amino acid
SD85_RS06850	COG0346	lactoylglutathione lyase activity
SD85_RS06855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD85_RS06860	COG0463	Glycosyl transferase, family 2
SD85_RS06870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD85_RS06875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD85_RS06880	COG2362	D-Aminopeptidase
SD85_RS06885	COG0601	transmembrane transport
SD85_RS06890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SD85_RS06895	COG0444	Belongs to the ABC transporter superfamily
SD85_RS06900	COG4166	transmembrane transport
SD85_RS06905	COG1619	proteins homologs of microcin C7 resistance protein MccF
SD85_RS06910	COG4948	Mandelate Racemase Muconate Lactonizing
SD85_RS06915	COG0791	NLP P60 protein
SD85_RS06920	COG4608	Belongs to the ABC transporter superfamily
SD85_RS06925	COG2706	6-phosphogluconolactonase activity
SD85_RS06930	COG1834	amidinotransferase
SD85_RS06935	COG1607	acyl-coa hydrolase
SD85_RS06940	COG1017	nitric oxide dioxygenase activity
SD85_RS06940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SD85_RS06950	COG2323	membrane
SD85_RS06955	COG2318	DinB family
SD85_RS06960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS06965	COG2076	Multidrug Resistance protein
SD85_RS06970	COG2076	Multidrug Resistance protein
SD85_RS06975	COG0788	formyltetrahydrofolate deformylase activity
SD85_RS06980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SD85_RS06985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SD85_RS06990	COG1764	response to oxidative stress
SD85_RS06995	COG1846	Transcriptional regulator
SD85_RS07000	COG1764	response to oxidative stress
SD85_RS07005	COG0457	Tetratricopeptide repeat
SD85_RS07005	COG0463	Glycosyl transferase, family 2
SD85_RS07010	COG0590	tRNA wobble adenosine to inosine editing
SD85_RS07020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SD85_RS07025	COG1404	Belongs to the peptidase S8 family
SD85_RS07030	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS07035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SD85_RS07040	COG1122	ATPase activity
SD85_RS07045	COG4721	ABC-type cobalt transport system, permease component
SD85_RS07055	COG0745	RESPONSE REGULATOR receiver
SD85_RS07060	COG3850	Histidine kinase
SD85_RS07060	COG5002	protein histidine kinase activity
SD85_RS07065	COG3212	peptidase
SD85_RS07070	COG3212	peptidase
SD85_RS07085	COG2239	Acts as a magnesium transporter
SD85_RS07090	COG0789	Transcriptional regulator
SD85_RS07105	COG1846	Transcriptional regulator
SD85_RS07110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SD85_RS07115	COG0726	polysaccharide deacetylase
SD85_RS07120	COG1408	metallophosphoesterase
SD85_RS07130	COG0463	Glycosyl transferase, family 2
SD85_RS07135	COG1793	dna ligase
SD85_RS07135	COG3285	dna ligase
SD85_RS07140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SD85_RS07145	COG3300	MHYT domain
SD85_RS07145	COG5001	Diguanylate cyclase
SD85_RS07150	COG0586	Pfam SNARE associated Golgi protein
SD85_RS07155	COG0861	Integral membrane protein TerC family
SD85_RS07160	COG1191	sigma factor activity
SD85_RS07180	COG0501	Belongs to the peptidase M48B family
SD85_RS07185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SD85_RS07200	COG3594	Acyltransferase
SD85_RS07205	COG5002	protein histidine kinase activity
SD85_RS07210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SD85_RS07220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SD85_RS07225	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
SD85_RS07230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SD85_RS07235	COG0436	Aminotransferase
SD85_RS07240	COG1850	ribulose-bisphosphate carboxylase activity
SD85_RS07245	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
SD85_RS07250	COG0235	Class ii aldolase
SD85_RS07255	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SD85_RS07260	COG3339	Conserved Protein
SD85_RS07275	COG3852	Histidine kinase
SD85_RS07280	COG1846	Transcriptional regulator
SD85_RS07285	COG1360	Flagellar Motor Protein
SD85_RS07290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SD85_RS07295	COG0542	response to heat
SD85_RS07300	COG3949	Membrane
SD85_RS07305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SD85_RS07310	COG0720	synthase
SD85_RS07315	COG0602	queuosine metabolic process
SD85_RS07320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SD85_RS07335	COG4873	Protein conserved in bacteria
SD85_RS07350	COG3773	Cell wall hydrolase
SD85_RS07355	COG2244	polysaccharide biosynthetic process
SD85_RS07360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS07365	COG2217	Heavy metal translocating P-type atpase
SD85_RS07375	COG0006	proline dipeptidase activity
SD85_RS07385	COG1609	Transcriptional regulator
SD85_RS07390	COG3711	transcriptional antiterminator
SD85_RS07395	COG2190	(PTS) system
SD85_RS07395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS07395	COG1263	PTS System
SD85_RS07400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS07405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SD85_RS07415	COG1533	DNA photolyase activity
SD85_RS07420	COG0456	acetyltransferase
SD85_RS07425	COG0840	transmembrane signaling receptor activity
SD85_RS07430	COG2084	Dehydrogenase
SD85_RS07435	COG2340	Cysteine-rich secretory protein family
SD85_RS07440	COG0768	penicillin binding
SD85_RS07445	COG4191	Histidine kinase
SD85_RS07450	COG0436	Aminotransferase
SD85_RS07460	COG0835	chemotaxis
SD85_RS07460	COG0784	Response regulator, receiver
SD85_RS07470	COG2814	Major facilitator Superfamily
SD85_RS07475	COG1376	ErfK ybiS ycfS ynhG family protein
SD85_RS07480	COG1408	metallophosphoesterase
SD85_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS07490	COG2200	EAL domain
SD85_RS07500	COG4703	Protein of unknown function (DUF1797)
SD85_RS07505	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
SD85_RS07515	COG0517	IMP dehydrogenase activity
SD85_RS07520	COG0583	DNA-binding transcription factor activity
SD85_RS07525	COG0716	FMN binding
SD85_RS07535	COG0716	FMN binding
SD85_RS07540	COG2171	N-acyltransferase activity
SD85_RS07545	COG1473	amidohydrolase
SD85_RS07555	COG0668	transmembrane transport
SD85_RS07560	COG0450	alkyl hydroperoxide reductase
SD85_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS07580	COG0746	molybdenum cofactor guanylyltransferase activity
SD85_RS07585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SD85_RS07590	COG0303	'Molybdopterin
SD85_RS07595	COG1763	Mo-molybdopterin cofactor biosynthetic process
SD85_RS07600	COG0314	molybdopterin synthase activity
SD85_RS07605	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SD85_RS07610	COG1132	(ABC) transporter
SD85_RS07615	COG1132	(ABC) transporter
SD85_RS07625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SD85_RS07630	COG1136	(ABC) transporter
SD85_RS07635	COG0577	efflux transmembrane transporter activity
SD85_RS07640	COG1349	DNA-binding transcription factor activity
SD85_RS07645	COG1105	Belongs to the carbohydrate kinase PfkB family
SD85_RS07650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS07650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SD85_RS07650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SD85_RS07655	COG2801	Transposase and inactivated derivatives
SD85_RS07665	COG0681	Belongs to the peptidase S26 family
SD85_RS07675	COG0488	(ABC) transporter
SD85_RS07680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SD85_RS07685	COG2309	aminopeptidase activity
SD85_RS07695	COG1077	Cell shape determining protein MreB Mrl
SD85_RS07700	COG2002	toxin-antitoxin pair type II binding
SD85_RS07705	COG3852	Histidine kinase
SD85_RS07710	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SD85_RS07710	COG2105	PFAM AIG2 family protein
SD85_RS07715	COG0569	domain protein
SD85_RS07720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SD85_RS07725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SD85_RS07730	COG5503	Protein of unknown function (DUF1447)
SD85_RS07735	COG0561	phosphatase activity
SD85_RS07740	COG0242	peptide deformylase activity
SD85_RS07750	COG0497	DNA recombination
SD85_RS07755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SD85_RS07760	COG0022	dehydrogenase e1 component
SD85_RS07765	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD85_RS07770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD85_RS07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS07785	COG2801	Transposase and inactivated derivatives
SD85_RS07790	COG1982	Orn Lys Arg decarboxylase major
SD85_RS07795	COG4476	Belongs to the UPF0223 family
SD85_RS07800	COG4493	Belongs to the UPF0637 family
SD85_RS07810	COG0483	inositol monophosphate 1-phosphatase activity
SD85_RS07820	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SD85_RS07840	COG1595	DNA-templated transcription, initiation
SD85_RS07860	COG1217	gtp-binding protein TYPA
SD85_RS07870	COG4896	Protein conserved in bacteria
SD85_RS07880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SD85_RS07885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SD85_RS07890	COG2066	Belongs to the glutaminase family
SD85_RS07895	COG4838	Belongs to the UPF0358 family
SD85_RS07900	COG0772	Belongs to the SEDS family
SD85_RS07905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SD85_RS07910	COG1612	heme a metabolic process
SD85_RS07915	COG0109	protoheme IX farnesyltransferase activity
SD85_RS07920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SD85_RS07920	COG2010	Cytochrome c
SD85_RS07925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SD85_RS07930	COG1845	cytochrome c oxidase, subunit III
SD85_RS07935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SD85_RS07940	COG3336	cytochrome c oxidase
SD85_RS07950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SD85_RS07955	COG2340	Cysteine-rich secretory protein family
SD85_RS07970	COG3679	Belongs to the UPF0342 family
SD85_RS07975	COG4471	UPF0298 protein
SD85_RS07980	COG0742	ribosomal rna small subunit methyltransferase
SD85_RS07985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SD85_RS07990	COG3314	Sporulation integral membrane protein YlbJ
SD85_RS07995	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD85_RS08000	COG3480	Lon protease (S16) C-terminal proteolytic domain
SD85_RS08005	COG1323	Belongs to the UPF0348 family
SD85_RS08010	COG1399	metal-binding, possibly nucleic acid-binding protein
SD85_RS08025	COG0454	-acetyltransferase
SD85_RS08030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SD85_RS08035	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SD85_RS08040	COG2001	Belongs to the MraZ family
SD85_RS08045	COG0275	rRNA processing
SD85_RS08050	COG4839	cell division protein FtsL
SD85_RS08055	COG0768	penicillin binding
SD85_RS08065	COG0768	penicillin binding
SD85_RS08075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SD85_RS08085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD85_RS08090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SD85_RS08095	COG0772	Belongs to the SEDS family
SD85_RS08100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SD85_RS08105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SD85_RS08110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SD85_RS08115	COG3879	Bacterial protein of unknown function (DUF881)
SD85_RS08120	COG3879	Bacterial protein of unknown function (DUF881)
SD85_RS08125	COG3856	small basic protein
SD85_RS08130	COG0849	cell division
SD85_RS08135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SD85_RS08140	COG4412	M6 family metalloprotease domain protein
SD85_RS08140	COG1404	Belongs to the peptidase S8 family
SD85_RS08150	COG1191	sigma factor activity
SD85_RS08155	COG1191	sigma factor activity
SD85_RS08160	COG1119	ATPase activity
SD85_RS08165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD85_RS08170	COG1873	PFAM PRC-barrel domain
SD85_RS08175	COG1496	oxidoreductase activity
SD85_RS08180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SD85_RS08185	COG1799	cell septum assembly
SD85_RS08190	COG0762	integral membrane protein
SD85_RS08195	COG2302	S4 RNA-binding domain
SD85_RS08200	COG3599	regulation of cell shape
SD85_RS08205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SD85_RS08210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SD85_RS08215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SD85_RS08220	COG0564	pseudouridine synthase activity
SD85_RS08225	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SD85_RS08230	COG2233	PERMEase
SD85_RS08235	COG0540	Belongs to the ATCase OTCase family
SD85_RS08240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD85_RS08245	COG0505	Belongs to the CarA family
SD85_RS08250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SD85_RS08255	COG0543	2 iron, 2 sulfur cluster binding
SD85_RS08260	COG0167	dihydroorotate dehydrogenase activity
SD85_RS08265	COG0284	orotidine-5'-phosphate decarboxylase activity
SD85_RS08270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SD85_RS08280	COG0175	sulfate reduction
SD85_RS08285	COG0306	phosphate transporter
SD85_RS08290	COG2046	Belongs to the sulfate adenylyltransferase family
SD85_RS08295	COG0529	Catalyzes the synthesis of activated sulfate
SD85_RS08300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SD85_RS08305	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SD85_RS08310	COG1648	precorrin-2 dehydrogenase activity
SD85_RS08315	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SD85_RS08320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SD85_RS08325	COG1561	YicC-like family, N-terminal region
SD85_RS08335	COG0194	GDP metabolic process
SD85_RS08340	COG1758	RNA polymerase activity
SD85_RS08345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SD85_RS08350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SD85_RS08355	COG0242	peptide deformylase activity
SD85_RS08360	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SD85_RS08365	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SD85_RS08365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SD85_RS08370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SD85_RS08375	COG0631	protein serine/threonine phosphatase activity
SD85_RS08380	COG2815	serine threonine protein kinase
SD85_RS08380	COG0515	serine threonine protein kinase
SD85_RS08385	COG1162	GTPase activity
SD85_RS08390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SD85_RS08395	COG1564	THIamine pyrophosphokinase
SD85_RS08405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SD85_RS08410	COG1302	Protein conserved in bacteria
SD85_RS08415	COG1461	Dihydroxyacetone kinase
SD85_RS08420	COG1760	l-serine dehydratase
SD85_RS08425	COG1760	l-serine dehydratase
SD85_RS08430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SD85_RS08435	COG2050	protein possibly involved in aromatic compounds catabolism
SD85_RS08435	COG1349	DNA-binding transcription factor activity
SD85_RS08440	COG0416	fatty acid biosynthetic process
SD85_RS08445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SD85_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS08460	COG0571	ribonuclease III activity
SD85_RS08465	COG1196	nuclear chromosome segregation
SD85_RS08470	COG0552	protein localization to endoplasmic reticulum
SD85_RS08480	COG2801	Transposase and inactivated derivatives
SD85_RS08490	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SD85_RS08495	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SD85_RS08500	COG0228	four-way junction DNA binding
SD85_RS08505	COG1837	Belongs to the UPF0109 family
SD85_RS08515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SD85_RS08520	COG0336	Belongs to the RNA methyltransferase TrmD family
SD85_RS08525	COG0335	large ribosomal subunit rRNA binding
SD85_RS08535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SD85_RS08545	COG2257	FlhB HrpN YscU SpaS Family
SD85_RS08550	COG0045	succinate-CoA ligase (ADP-forming) activity
SD85_RS08555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SD85_RS08560	COG0758	DNA mediated transformation
SD85_RS08565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SD85_RS08570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SD85_RS08575	COG4974	Belongs to the 'phage' integrase family
SD85_RS08580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SD85_RS08590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD85_RS08595	COG1815	bacterial-type flagellum-dependent cell motility
SD85_RS08600	COG1558	bacterial-type flagellum-dependent cell motility
SD85_RS08605	COG1677	Flagellar hook-basal body complex protein FliE
SD85_RS08610	COG1766	The M ring may be actively involved in energy transduction
SD85_RS08615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SD85_RS08620	COG1317	bacterial-type flagellum organization
SD85_RS08625	COG1157	protein secretion by the type III secretion system
SD85_RS08630	COG2882	bacterial-type flagellum organization
SD85_RS08635	COG3334	PFAM MgtE intracellular
SD85_RS08640	COG3144	bacterial-type flagellum assembly
SD85_RS08645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SD85_RS08650	COG4786	Flagellar basal body rod
SD85_RS08655	COG1582	Flagellar protein (FlbD)
SD85_RS08660	COG1580	Controls the rotational direction of flagella during chemotaxis
SD85_RS08665	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SD85_RS08670	COG1776	CheC inhibitor of MCP methylation
SD85_RS08670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SD85_RS08675	COG2201	protein-glutamate methylesterase activity
SD85_RS08680	COG3190	flagellar
SD85_RS08685	COG1338	Plays a role in the flagellum-specific transport system
SD85_RS08690	COG1987	bacterial-type flagellum assembly
SD85_RS08695	COG1684	flagellar biosynthetic protein fliR
SD85_RS08700	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SD85_RS08705	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SD85_RS08710	COG1419	protein localization to endoplasmic reticulum
SD85_RS08715	COG0455	bacterial-type flagellum organization
SD85_RS08720	COG2201	protein-glutamate methylesterase activity
SD85_RS08725	COG0643	Histidine kinase
SD85_RS08725	COG2198	Histidine kinase
SD85_RS08730	COG0835	chemotaxis
SD85_RS08735	COG1776	CheC inhibitor of MCP methylation
SD85_RS08740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SD85_RS08745	COG1191	sigma factor activity
SD85_RS08755	COG0052	Belongs to the universal ribosomal protein uS2 family
SD85_RS08760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SD85_RS08765	COG0528	UMP kinase activity
SD85_RS08770	COG0233	cytoplasmic translational termination
SD85_RS08775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SD85_RS08780	COG4589	Belongs to the CDS family
SD85_RS08785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SD85_RS08790	COG0750	zinc metalloprotease
SD85_RS08795	COG0442	prolyl-tRNA aminoacylation
SD85_RS08800	COG2176	DNA-directed DNA polymerase activity
SD85_RS08805	COG0779	Required for maturation of 30S ribosomal subunits
SD85_RS08810	COG0195	Participates in both transcription termination and antitermination
SD85_RS08815	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SD85_RS08820	COG1358	cellular component organization or biogenesis
SD85_RS08825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SD85_RS08830	COG1550	Protein conserved in bacteria
SD85_RS08835	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SD85_RS08840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SD85_RS08845	COG0196	riboflavin kinase activity
SD85_RS08850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SD85_RS08855	COG1185	polyribonucleotide nucleotidyltransferase activity
SD85_RS08860	COG0726	polysaccharide deacetylase
SD85_RS08865	COG0612	Peptidase, M16
SD85_RS08870	COG1873	PFAM PRC-barrel domain
SD85_RS08875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SD85_RS08880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SD85_RS08885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SD85_RS08890	COG0527	aspartate kinase activity
SD85_RS08895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SD85_RS08900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SD85_RS08905	COG0740	serine-type endopeptidase activity
SD85_RS08915	COG4980	gas vesicle protein
SD85_RS08915	COG1674	ftsk spoiiie
SD85_RS08920	COG2188	Transcriptional regulator
SD85_RS08925	COG2814	Major facilitator Superfamily
SD85_RS08930	COG0612	Peptidase, M16
SD85_RS08935	COG0612	Peptidase, M16
SD85_RS08940	COG0300	oxidoreductase activity
SD85_RS08955	COG1426	Protein conserved in bacteria
SD85_RS08960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SD85_RS08965	COG1058	Belongs to the CinA family
SD85_RS08965	COG1546	Belongs to the CinA family
SD85_RS08970	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SD85_RS08975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD85_RS08980	COG1418	mRNA catabolic process
SD85_RS08985	COG1692	metallophosphoesterase
SD85_RS08990	COG2359	stage V sporulation protein S
SD85_RS08995	COG1063	alcohol dehydrogenase
SD85_RS09000	COG0156	8-amino-7-oxononanoate synthase activity
SD85_RS09005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD85_RS09010	COG4550	Control of competence regulator ComK, YlbF/YmcA
SD85_RS09020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SD85_RS09025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SD85_RS09050	COG3226	Transcriptional regulator
SD85_RS09055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS09065	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SD85_RS09070	COG3321	synthase
SD85_RS09075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SD85_RS09075	COG2070	2-Nitropropane dioxygenase
SD85_RS09080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD85_RS09085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SD85_RS09090	COG3425	synthase
SD85_RS09095	COG1024	Enoyl-CoA hydratase
SD85_RS09100	COG1024	Enoyl-CoA hydratase
SD85_RS09105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS09105	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS09105	COG0300	oxidoreductase activity
SD85_RS09105	COG3321	synthase
SD85_RS09105	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS09110	COG0300	oxidoreductase activity
SD85_RS09110	COG4221	oxidoreductase activity
SD85_RS09110	COG3321	synthase
SD85_RS09110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD85_RS09115	COG3321	synthase
SD85_RS09115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS09115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD85_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD85_RS09120	COG4221	oxidoreductase activity
SD85_RS09120	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS09120	COG3321	synthase
SD85_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS09125	COG3321	synthase
SD85_RS09125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD85_RS09125	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SD85_RS09125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SD85_RS09130	COG2124	cytochrome p450
SD85_RS09140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS09145	COG1404	Belongs to the peptidase S8 family
SD85_RS09155	COG4195	phage-related replication protein
SD85_RS09160	COG1764	response to oxidative stress
SD85_RS09185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SD85_RS09190	COG1923	regulation of RNA biosynthetic process
SD85_RS09205	COG1780	Probably involved in ribonucleotide reductase function
SD85_RS09210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD85_RS09215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SD85_RS09220	COG4112	unkown
SD85_RS09225	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS09235	COG0464	growth
SD85_RS09245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SD85_RS09250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SD85_RS09255	COG0789	Transcriptional regulator
SD85_RS09260	COG0174	glutamine synthetase
SD85_RS09275	COG2211	Major facilitator Superfamily
SD85_RS09280	COG3507	Belongs to the glycosyl hydrolase 43 family
SD85_RS09295	COG1070	Carbohydrate kinase
SD85_RS09310	COG2814	Major facilitator Superfamily
SD85_RS09315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SD85_RS09325	COG0756	dUTP diphosphatase activity
SD85_RS09375	COG3832	glyoxalase III activity
SD85_RS09390	COG2059	Chromate
SD85_RS09395	COG0697	spore germination
SD85_RS09420	COG4195	phage-related replication protein
SD85_RS09430	COG0346	lactoylglutathione lyase activity
SD85_RS09445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SD85_RS09450	COG1388	LysM domain
SD85_RS09455	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SD85_RS09460	COG4224	UPF0291 protein
SD85_RS09465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SD85_RS09475	COG3763	UPF0154 protein
SD85_RS09485	COG0785	Cytochrome C biogenesis protein
SD85_RS09490	COG2201	protein-glutamate methylesterase activity
SD85_RS09495	COG4846	Membrane protein involved in cytochrome C biogenesis
SD85_RS09505	COG0071	Belongs to the small heat shock protein (HSP20) family
SD85_RS09520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SD85_RS09525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS09545	COG0824	Thioesterase
SD85_RS09555	COG4841	protein insertion into membrane
SD85_RS09560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SD85_RS09565	COG1832	CoA-binding protein
SD85_RS09570	COG0187	DNA topoisomerase II activity
SD85_RS09575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SD85_RS09590	COG1115	amino acid carrier protein
SD85_RS09595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SD85_RS09605	COG2246	polysaccharide biosynthetic process
SD85_RS09610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SD85_RS09615	COG0586	Pfam SNARE associated Golgi protein
SD85_RS09635	COG2404	hydrolase activity, acting on ester bonds
SD85_RS09640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD85_RS09645	COG1024	Enoyl-CoA hydratase
SD85_RS09650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SD85_RS09655	COG0511	ligase activity, forming carbon-carbon bonds
SD85_RS09660	COG0439	Biotin carboxylase
SD85_RS09665	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS09670	COG1960	acyl-CoA dehydrogenase activity
SD85_RS09685	COG1649	PFAM Uncharacterised BCR, COG1649
SD85_RS09715	COG2027	D-alanyl-D-alanine carboxypeptidase
SD85_RS09720	COG2017	converts alpha-aldose to the beta-anomer
SD85_RS09725	COG0534	Mate efflux family protein
SD85_RS09750	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS09750	COG1388	LysM domain
SD85_RS09750	COG5632	N-Acetylmuramoyl-L-alanine amidase
SD85_RS09785	COG1705	Flagellar rod assembly protein muramidase FlgJ
SD85_RS09785	COG3942	CHAP domain
SD85_RS09900	COG0582	viral genome integration into host DNA
SD85_RS09995	COG0582	viral genome integration into host DNA
SD85_RS10000	COG0166	Belongs to the GPI family
SD85_RS10005	COG0405	Gamma-glutamyltransferase
SD85_RS10010	COG0583	DNA-binding transcription factor activity
SD85_RS10020	COG0493	'glutamate synthase
SD85_RS10025	COG0070	glutamate synthase
SD85_RS10025	COG0069	glutamate synthase activity
SD85_RS10025	COG0067	glutamate synthase
SD85_RS10030	COG0583	DNA-binding transcription factor activity
SD85_RS10035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SD85_RS10055	COG0300	oxidoreductase activity
SD85_RS10060	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SD85_RS10070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS10085	COG1131	(ABC) transporter
SD85_RS10095	COG2814	Major facilitator Superfamily
SD85_RS10100	COG1070	Carbohydrate kinase
SD85_RS10105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD85_RS10110	COG0243	molybdopterin cofactor binding
SD85_RS10140	COG0840	transmembrane signaling receptor activity
SD85_RS10140	COG5278	phosphoserine phosphatase activity
SD85_RS10145	COG2368	4-hydroxyphenylacetate
SD85_RS10150	COG4305	rare lipoprotein A
SD85_RS10155	COG3619	membrane
SD85_RS10165	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS10180	COG2135	peptidase activity
SD85_RS10220	COG2720	vancomycin resistance protein
SD85_RS10230	COG3655	Transcriptional regulator
SD85_RS10235	COG3739	integral membrane protein
SD85_RS10240	COG0583	DNA-binding transcription factor activity
SD85_RS10245	COG0697	spore germination
SD85_RS10270	COG0693	protein deglycase activity
SD85_RS10275	COG2367	Beta-lactamase
SD85_RS10285	COG3397	chitin binding
SD85_RS10290	COG2318	DinB family
SD85_RS10295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SD85_RS10300	COG0457	Tetratricopeptide repeat
SD85_RS10310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD85_RS10315	COG1215	transferase activity, transferring glycosyl groups
SD85_RS10320	COG0463	Glycosyl transferase, family 2
SD85_RS10355	COG4974	Belongs to the 'phage' integrase family
SD85_RS10370	COG2273	Hydrolase Family 16
SD85_RS10375	COG4282	regulation of fungal-type cell wall biogenesis
SD85_RS10380	COG1231	oxidoreductase activity
SD85_RS10385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD85_RS10390	COG2207	Transcriptional regulator
SD85_RS10390	COG0662	Cupin 2, conserved barrel domain protein
SD85_RS10395	COG0456	acetyltransferase
SD85_RS10405	COG1309	transcriptional regulator
SD85_RS10415	COG3708	Transcriptional regulator
SD85_RS10420	COG2378	regulation of single-species biofilm formation
SD85_RS10430	COG0640	Transcriptional regulator
SD85_RS10435	COG0741	lytic transglycosylase activity
SD85_RS10440	COG2322	membrane
SD85_RS10455	COG1619	proteins homologs of microcin C7 resistance protein MccF
SD85_RS10460	COG3239	Fatty acid desaturase
SD85_RS10465	COG4585	Histidine kinase
SD85_RS10470	COG2197	response regulator
SD85_RS10475	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS10480	COG1388	LysM domain
SD85_RS10480	COG3584	3D domain protein
SD85_RS10485	COG0514	ATP-dependent DNA helicase (RecQ)
SD85_RS10490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD85_RS10495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SD85_RS10510	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS10515	COG1657	PFAM Prenyltransferase squalene oxidase
SD85_RS10520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SD85_RS10525	COG0733	neurotransmitter:sodium symporter activity
SD85_RS10530	COG0385	Bile acid
SD85_RS10535	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD85_RS10540	COG0567	Dehydrogenase, E1 component
SD85_RS10545	COG4548	von Willebrand factor, type A
SD85_RS10550	COG0714	Associated with various cellular activities
SD85_RS10555	COG2032	superoxide dismutase activity
SD85_RS10560	COG1388	LysM domain
SD85_RS10560	COG0791	NLP P60 protein
SD85_RS10565	COG1819	glycosyl
SD85_RS10570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SD85_RS10575	COG0534	Mate efflux family protein
SD85_RS10580	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS10585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD85_RS10590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD85_RS10600	COG2962	Rard protein
SD85_RS10615	COG1942	4-Oxalocrotonate Tautomerase
SD85_RS10620	COG1733	regulation of RNA biosynthetic process
SD85_RS10625	COG0778	Nitroreductase
SD85_RS10630	COG0400	carboxylic ester hydrolase activity
SD85_RS10645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS10650	COG0793	Belongs to the peptidase S41A family
SD85_RS10650	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS10655	COG2226	methyltransferase
SD85_RS10665	COG1876	peptidase activity
SD85_RS10670	COG0813	purine-nucleoside phosphorylase activity
SD85_RS10685	COG0671	phosphoesterase, PA-phosphatase related
SD85_RS10705	COG4479	Belongs to the UPF0346 family
SD85_RS10715	COG1509	lysine 2,3-aminomutase activity
SD85_RS10720	COG0456	acetyltransferase
SD85_RS10725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD85_RS10730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SD85_RS10735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SD85_RS10740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD85_RS10755	COG0456	acetyltransferase
SD85_RS10760	COG0463	Glycosyl transferase, family 2
SD85_RS10775	COG4641	Protein conserved in bacteria
SD85_RS10780	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
SD85_RS10785	COG1086	Polysaccharide biosynthesis protein
SD85_RS10790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD85_RS10795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SD85_RS10800	COG1846	Transcriptional regulator
SD85_RS10805	COG0534	Mate efflux family protein
SD85_RS10815	COG4698	Protein conserved in bacteria
SD85_RS10820	COG2755	lipolytic protein G-D-S-L family
SD85_RS10825	COG1999	signal sequence binding
SD85_RS10840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SD85_RS10845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SD85_RS10850	COG1272	protein, Hemolysin III
SD85_RS10855	COG0204	Acyl-transferase
SD85_RS10860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SD85_RS10870	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SD85_RS10880	COG2136	Putative SAM-dependent methyltransferase
SD85_RS10880	COG2521	methyltransferase
SD85_RS10890	COG0129	dihydroxy-acid dehydratase activity
SD85_RS10895	COG1413	lyase activity
SD85_RS10900	COG1418	mRNA catabolic process
SD85_RS10905	COG0386	Belongs to the glutathione peroxidase family
SD85_RS10910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SD85_RS10915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SD85_RS10920	COG1278	Cold shock
SD85_RS10940	COG0328	RNA-DNA hybrid ribonuclease activity
SD85_RS10945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SD85_RS10950	COG0328	RNA-DNA hybrid ribonuclease activity
SD85_RS10960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SD85_RS10975	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SD85_RS10980	COG1755	Isoprenylcysteine carboxyl methyltransferase
SD85_RS10985	COG3424	synthase
SD85_RS10990	COG2233	PERMEase
SD85_RS10995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SD85_RS11000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SD85_RS11010	COG0800	Aldolase
SD85_RS11015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD85_RS11020	COG1609	Transcriptional regulator
SD85_RS11025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SD85_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS11035	COG1199	ATP-dependent helicase activity
SD85_RS11045	COG0116	Belongs to the methyltransferase superfamily
SD85_RS11055	COG4474	Belongs to the UPF0398 family
SD85_RS11070	COG3359	exonuclease
SD85_RS11075	COG1111	helicase
SD85_RS11075	COG1205	dead DEAH box helicase
SD85_RS11080	COG2190	(PTS) system
SD85_RS11085	COG0071	Belongs to the small heat shock protein (HSP20) family
SD85_RS11120	COG3331	DNA recombination
SD85_RS11125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD85_RS11125	COG4499	WXG100 protein secretion system (Wss), protein YukC
SD85_RS11135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SD85_RS11140	COG3935	DnaD domain protein
SD85_RS11145	COG0017	Asparaginyl-tRNA synthetase
SD85_RS11150	COG0436	Aminotransferase
SD85_RS11155	COG5353	protein conserved in bacteria
SD85_RS11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SD85_RS11165	COG1199	ATP-dependent helicase activity
SD85_RS11170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SD85_RS11175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SD85_RS11180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SD85_RS11190	COG0617	tRNA 3'-terminal CCA addition
SD85_RS11195	COG0438	transferase activity, transferring glycosyl groups
SD85_RS11200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SD85_RS11205	COG1803	Methylglyoxal synthase
SD85_RS11210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SD85_RS11215	COG1694	Mazg nucleotide pyrophosphohydrolase
SD85_RS11220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS11230	COG4347	Protein of unknown function (DUF1405)
SD85_RS11235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SD85_RS11235	COG2010	Cytochrome c
SD85_RS11240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SD85_RS11245	COG0723	plastoquinol--plastocyanin reductase activity
SD85_RS11255	COG5582	Belongs to the UPF0302 family
SD85_RS11260	COG0457	Tetratricopeptide repeat
SD85_RS11265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SD85_RS11270	COG0287	Prephenate dehydrogenase
SD85_RS11275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SD85_RS11280	COG0159	tryptophan synthase activity
SD85_RS11285	COG0133	tryptophan synthase activity
SD85_RS11290	COG0135	phosphoribosylanthranilate isomerase activity
SD85_RS11300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SD85_RS11305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SD85_RS11310	COG4401	Chorismate mutase type I
SD85_RS11315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SD85_RS11320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SD85_RS11325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SD85_RS11335	COG0105	UTP biosynthetic process
SD85_RS11340	COG0142	geranyltranstransferase activity
SD85_RS11345	COG2226	methyltransferase
SD85_RS11350	COG0142	geranyltranstransferase activity
SD85_RS11360	COG0302	gtp cyclohydrolase
SD85_RS11365	COG0776	regulation of translation
SD85_RS11370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SD85_RS11385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SD85_RS11390	COG1160	GTP binding
SD85_RS11415	COG1304	FMN binding
SD85_RS11420	COG0539	negative regulation of cytoplasmic translation
SD85_RS11425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SD85_RS11435	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SD85_RS11440	COG2959	enzyme of heme biosynthesis
SD85_RS11445	COG3773	Cell wall hydrolase
SD85_RS11445	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS11450	COG2339	peptidase activity
SD85_RS11455	COG0492	ferredoxin-NADP+ reductase activity
SD85_RS11460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SD85_RS11465	COG4862	establishment of competence for transformation
SD85_RS11470	COG1408	metallophosphoesterase
SD85_RS11480	COG1388	LysM domain
SD85_RS11485	COG1266	CAAX protease self-immunity
SD85_RS11490	COG0514	ATP-dependent DNA helicase (RecQ)
SD85_RS11495	COG4955	Helix-turn-helix domain
SD85_RS11500	COG1141	Ferredoxin
SD85_RS11505	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SD85_RS11515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SD85_RS11520	COG0710	3-dehydroquinate dehydratase activity
SD85_RS11530	COG1595	DNA-templated transcription, initiation
SD85_RS11535	COG5002	protein histidine kinase activity
SD85_RS11540	COG0745	RESPONSE REGULATOR receiver
SD85_RS11545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SD85_RS11550	COG1333	cytochrome c biogenesis protein
SD85_RS11555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS11560	COG1187	pseudouridine synthase activity
SD85_RS11565	COG0700	Nucleoside recognition
SD85_RS11570	COG2715	membrane protein required for spore maturation
SD85_RS11575	COG1686	Belongs to the peptidase S11 family
SD85_RS11585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SD85_RS11590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SD85_RS11595	COG1547	Domain of unknown function (DUF309)
SD85_RS11600	COG0456	acetyltransferase
SD85_RS11605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SD85_RS11610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD85_RS11610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SD85_RS11615	COG0307	riboflavin synthase, alpha
SD85_RS11620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD85_RS11620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SD85_RS11630	COG0681	Belongs to the peptidase S26 family
SD85_RS11635	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
SD85_RS11645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SD85_RS11655	COG4086	secreted protein
SD85_RS11660	COG0019	diaminopimelate decarboxylase activity
SD85_RS11665	COG0697	spore germination
SD85_RS11680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SD85_RS11700	COG1191	sigma factor activity
SD85_RS11705	COG2172	sigma factor antagonist activity
SD85_RS11710	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS11715	COG1686	Belongs to the peptidase S11 family
SD85_RS11720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SD85_RS11725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SD85_RS11730	COG4974	Belongs to the 'phage' integrase family
SD85_RS11740	COG0735	belongs to the Fur family
SD85_RS11745	COG1300	Membrane
SD85_RS11755	COG0281	malic enzyme
SD85_RS11760	COG1757	Na H antiporter
SD85_RS11765	COG1027	Aspartate ammonia-lyase
SD85_RS11770	COG0252	asparaginase activity
SD85_RS11775	COG1396	sequence-specific DNA binding
SD85_RS11785	COG2801	Transposase and inactivated derivatives
SD85_RS11790	COG1379	DNA repair
SD85_RS11795	COG0494	nUDIX hydrolase
SD85_RS11805	COG0667	Aldo Keto reductase
SD85_RS11815	COG1073	alpha beta
SD85_RS11820	COG0772	Belongs to the SEDS family
SD85_RS11825	COG0772	Belongs to the SEDS family
SD85_RS11830	COG3339	Conserved Protein
SD85_RS11840	COG4918	Iron-sulphur cluster biosynthesis
SD85_RS11845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SD85_RS11845	COG0456	acetyltransferase
SD85_RS11850	COG2329	Antibiotic biosynthesis monooxygenase
SD85_RS11855	COG0456	acetyltransferase
SD85_RS11865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD85_RS11880	COG2211	Major facilitator Superfamily
SD85_RS11890	COG0346	lactoylglutathione lyase activity
SD85_RS11895	COG1072	(Pantothenic acid kinase))
SD85_RS11900	COG3048	D-serine ammonia-lyase activity
SD85_RS11905	COG0300	oxidoreductase activity
SD85_RS11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS11915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD85_RS11920	COG4187	Peptidase family M20/M25/M40
SD85_RS11925	COG1902	pentaerythritol trinitrate reductase activity
SD85_RS11930	COG0596	Alpha beta hydrolase
SD85_RS11950	COG1234	tRNA 3'-trailer cleavage
SD85_RS11955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SD85_RS11960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SD85_RS11965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SD85_RS11975	COG0706	membrane insertase activity
SD85_RS11980	COG3361	conserved protein (COG2071)
SD85_RS11985	COG2195	Cleaves the N-terminal amino acid of tripeptides
SD85_RS11990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SD85_RS11995	COG0346	lactoylglutathione lyase activity
SD85_RS12005	COG1376	ErfK ybiS ycfS ynhG family protein
SD85_RS12010	COG4129	membrane
SD85_RS12015	COG1126	abc transporter atp-binding protein
SD85_RS12020	COG0765	amino acid transport
SD85_RS12025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD85_RS12035	COG1597	lipid kinase activity
SD85_RS12040	COG2814	Major facilitator Superfamily
SD85_RS12045	COG4978	Transcriptional regulator
SD85_RS12045	COG0789	Transcriptional regulator
SD85_RS12050	COG0508	dehydrogenase complex catalyzes the overall conversion of
SD85_RS12055	COG0022	dehydrogenase e1 component
SD85_RS12060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SD85_RS12065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SD85_RS12070	COG3426	butyrate kinase activity
SD85_RS12075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SD85_RS12080	COG0280	phosphate acetyltransferase
SD85_RS12085	COG3829	transcription factor binding
SD85_RS12085	COG3290	protein histidine kinase activity
SD85_RS12095	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SD85_RS12100	COG2079	MmgE PrpD family protein
SD85_RS12105	COG0372	Belongs to the citrate synthase family
SD85_RS12110	COG1960	acyl-CoA dehydrogenase activity
SD85_RS12115	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD85_RS12120	COG0183	Belongs to the thiolase family
SD85_RS12125	COG0584	glycerophosphoryl diester phosphodiesterase
SD85_RS12130	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS12145	COG1902	pentaerythritol trinitrate reductase activity
SD85_RS12155	COG0745	RESPONSE REGULATOR receiver
SD85_RS12165	COG0750	zinc metalloprotease
SD85_RS12170	COG0497	DNA recombination
SD85_RS12175	COG1438	arginine binding
SD85_RS12180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SD85_RS12185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SD85_RS12190	COG0142	geranyltranstransferase activity
SD85_RS12195	COG1722	exodeoxyribonuclease VII activity
SD85_RS12200	COG1570	exodeoxyribonuclease VII activity
SD85_RS12205	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SD85_RS12210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SD85_RS12215	COG1302	Protein conserved in bacteria
SD85_RS12220	COG0439	Biotin carboxylase
SD85_RS12225	COG0511	ligase activity, forming carbon-carbon bonds
SD85_RS12265	COG3854	ATPases associated with a variety of cellular activities
SD85_RS12275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SD85_RS12280	COG0006	proline dipeptidase activity
SD85_RS12285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SD85_RS12295	COG3872	metal-dependent enzyme
SD85_RS12305	COG1752	Esterase of the alpha-beta hydrolase superfamily
SD85_RS12310	COG1321	iron dependent repressor
SD85_RS12315	COG0095	Lipoate-protein ligase
SD85_RS12320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SD85_RS12325	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD85_RS12330	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SD85_RS12335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SD85_RS12340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD85_RS12355	COG1396	sequence-specific DNA binding
SD85_RS12365	COG0681	Belongs to the peptidase S26 family
SD85_RS12390	COG4940	Competence protein ComGF
SD85_RS12400	COG4970	Tfp pilus assembly protein FimT
SD85_RS12405	COG4537	Required for transformation and DNA binding
SD85_RS12410	COG1459	type II secretion system
SD85_RS12415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SD85_RS12420	COG0517	IMP dehydrogenase activity
SD85_RS12425	COG0598	Magnesium transport protein CorA
SD85_RS12430	COG1253	flavin adenine dinucleotide binding
SD85_RS12435	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS12445	COG1393	Belongs to the ArsC family
SD85_RS12455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS12465	COG0011	TIGRFAM Protein of
SD85_RS12475	COG2866	Carboxypeptidase
SD85_RS12480	COG1368	sulfuric ester hydrolase activity
SD85_RS12485	COG1940	carbohydrate kinase activity
SD85_RS12490	COG4483	Protein conserved in bacteria
SD85_RS12495	COG0457	Tetratricopeptide repeat
SD85_RS12495	COG0705	Rhomboid family
SD85_RS12505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SD85_RS12515	COG0438	transferase activity, transferring glycosyl groups
SD85_RS12530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SD85_RS12535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SD85_RS12540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SD85_RS12545	COG0581	inorganic phosphate transmembrane transporter activity
SD85_RS12550	COG0573	inorganic phosphate transmembrane transporter activity
SD85_RS12555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SD85_RS12560	COG0768	penicillin binding
SD85_RS12565	COG0477	Major facilitator Superfamily
SD85_RS12570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SD85_RS12575	COG2839	Protein conserved in bacteria
SD85_RS12580	COG5521	maltodextrose utilization protein MalA
SD85_RS12585	COG1388	LysM domain
SD85_RS12590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SD85_RS12595	COG4709	membrane
SD85_RS12600	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
SD85_RS12605	COG0735	belongs to the Fur family
SD85_RS12610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS12620	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SD85_RS12625	COG0513	Belongs to the DEAD box helicase family
SD85_RS12635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SD85_RS12640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SD85_RS12645	COG2384	SAM-dependent methyltransferase
SD85_RS12650	COG2010	Cytochrome c
SD85_RS12655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SD85_RS12660	COG0358	DNA primase activity
SD85_RS12665	COG1671	Belongs to the UPF0178 family
SD85_RS12670	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SD85_RS12675	COG0517	IMP dehydrogenase activity
SD85_RS12680	COG0751	glycine-tRNA ligase activity
SD85_RS12685	COG0752	glycyl-tRNA synthetase alpha subunit
SD85_RS12690	COG1381	Involved in DNA repair and RecF pathway recombination
SD85_RS12700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SD85_RS12705	COG0295	cytidine deaminase activity
SD85_RS12710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SD85_RS12715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SD85_RS12720	COG1480	7TM receptor with intracellular HD hydrolase
SD85_RS12730	COG1702	phosphate starvation-inducible protein PhoH
SD85_RS12735	COG0561	phosphatase activity
SD85_RS12750	COG4864	UPF0365 protein
SD85_RS12755	COG1030	water channel activity
SD85_RS12760	COG1610	YqeY-like protein
SD85_RS12770	COG1283	sodium-dependent phosphate transmembrane transporter activity
SD85_RS12775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SD85_RS12780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SD85_RS12785	COG2264	protein methyltransferase activity
SD85_RS12790	COG0484	heat shock protein binding
SD85_RS12800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SD85_RS12805	COG1420	regulation of RNA biosynthetic process
SD85_RS12810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SD85_RS12815	COG0481	GTPase activity
SD85_RS12825	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS12830	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SD85_RS12835	COG0268	Binds directly to 16S ribosomal RNA
SD85_RS12840	COG1466	dna polymerase III delta subunit
SD85_RS12850	COG2333	competence protein COMEC
SD85_RS12850	COG0658	competence protein
SD85_RS12855	COG2131	deaminase
SD85_RS12860	COG1596	polysaccharide export
SD85_RS12860	COG1555	photosystem II stabilization
SD85_RS12865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SD85_RS12870	COG2226	methyltransferase
SD85_RS12875	COG0799	negative regulation of ribosome biogenesis
SD85_RS12880	COG1713	HD superfamily hydrolase involved in NAD metabolism
SD85_RS12885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SD85_RS12890	COG1534	Rna-binding protein
SD85_RS12895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SD85_RS12900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SD85_RS12905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SD85_RS12920	COG2755	lipolytic protein G-D-S-L family
SD85_RS12930	COG5632	N-Acetylmuramoyl-L-alanine amidase
SD85_RS12930	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS12935	COG0398	Pfam SNARE associated Golgi protein
SD85_RS12940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SD85_RS12950	COG3209	COG3209 Rhs family protein
SD85_RS12960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SD85_RS12965	COG0114	fumarate hydratase activity
SD85_RS12970	COG0583	DNA-binding transcription factor activity
SD85_RS12990	COG2070	2-Nitropropane dioxygenase
SD85_RS12995	COG1846	Transcriptional regulator
SD85_RS13005	COG1733	regulation of RNA biosynthetic process
SD85_RS13015	COG2207	Transcriptional regulator
SD85_RS13025	COG4221	oxidoreductase activity
SD85_RS13030	COG0456	acetyltransferase
SD85_RS13035	COG0789	Transcriptional regulator
SD85_RS13035	COG4978	Transcriptional regulator
SD85_RS13040	COG2814	Major facilitator Superfamily
SD85_RS13045	COG1183	phosphatidylcholine synthase activity
SD85_RS13055	COG2186	Transcriptional regulator
SD85_RS13060	COG0205	6-phosphofructokinase activity
SD85_RS13070	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS13075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SD85_RS13080	COG3959	Transketolase, thiamine diphosphate binding domain
SD85_RS13095	COG0640	Transcriptional regulator
SD85_RS13100	COG1115	amino acid carrier protein
SD85_RS13105	COG2315	Protein conserved in bacteria
SD85_RS13120	COG3443	Belongs to the bacterial solute-binding protein 9 family
SD85_RS13125	COG4991	sh3 domain protein
SD85_RS13130	COG4991	sh3 domain protein
SD85_RS13140	COG5577	PFAM Coat F domain
SD85_RS13145	COG1063	alcohol dehydrogenase
SD85_RS13155	COG5577	PFAM Coat F domain
SD85_RS13165	COG0667	Aldo Keto reductase
SD85_RS13170	COG2207	Transcriptional regulator
SD85_RS13175	COG0789	Transcriptional regulator
SD85_RS13180	COG0789	Transcriptional regulator
SD85_RS13185	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
SD85_RS13190	COG1064	alcohol dehydrogenase
SD85_RS13195	COG0693	protein deglycase activity
SD85_RS13200	COG1621	beta-fructofuranosidase activity
SD85_RS13205	COG3716	PTS system mannose fructose sorbose family IID component
SD85_RS13210	COG3715	PTS system
SD85_RS13215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS13220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS13225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SD85_RS13225	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SD85_RS13240	COG1113	amino acid transport
SD85_RS13245	COG1280	lysine exporter protein (LysE YggA)
SD85_RS13250	COG1378	Sugar-specific transcriptional regulator TrmB
SD85_RS13255	COG1595	DNA-templated transcription, initiation
SD85_RS13265	COG2755	lipolytic protein G-D-S-L family
SD85_RS13265	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SD85_RS13275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SD85_RS13275	COG2124	cytochrome p450
SD85_RS13280	COG1309	transcriptional regulator
SD85_RS13285	COG2226	methyltransferase
SD85_RS13305	COG2116	formate transmembrane transporter activity
SD85_RS13310	COG5609	conserved protein (DUF2294)
SD85_RS13315	COG3383	formate dehydrogenase (NAD+) activity
SD85_RS13320	COG2427	Protein of unknown function (DUF1641)
SD85_RS13330	COG0626	cystathionine gamma-synthase activity
SD85_RS13335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD85_RS13340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SD85_RS13345	COG2226	methyltransferase
SD85_RS13360	COG0768	penicillin binding
SD85_RS13365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SD85_RS13370	COG0572	uridine kinase
SD85_RS13375	COG0826	peptidase U32
SD85_RS13380	COG0826	peptidase U32
SD85_RS13385	COG4122	O-methyltransferase activity
SD85_RS13390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SD85_RS13395	COG3906	Belongs to the UPF0473 family
SD85_RS13400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SD85_RS13405	COG4472	Bacterial protein of unknown function (DUF965)
SD85_RS13410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SD85_RS13415	COG0628	permease
SD85_RS13430	COG3881	PFAM PRC-barrel domain
SD85_RS13435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SD85_RS13440	COG0457	Tetratricopeptide repeat
SD85_RS13445	COG0482	sulfurtransferase activity
SD85_RS13450	COG1104	cysteine desulfurase activity
SD85_RS13455	COG1959	2 iron, 2 sulfur cluster binding
SD85_RS13460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SD85_RS13475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SD85_RS13485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SD85_RS13490	COG0124	histidyl-tRNA synthetase
SD85_RS13505	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS13505	COG4991	sh3 domain protein
SD85_RS13505	COG3103	Sh3 type 3 domain protein
SD85_RS13510	COG1490	D-aminoacyl-tRNA deacylase activity
SD85_RS13515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SD85_RS13520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SD85_RS13525	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SD85_RS13525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SD85_RS13530	COG5416	Lipopolysaccharide assembly protein A domain
SD85_RS13535	COG0490	domain, Protein
SD85_RS13540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD85_RS13540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SD85_RS13550	COG2244	polysaccharide biosynthetic process
SD85_RS13555	COG2323	membrane
SD85_RS13565	COG1862	Preprotein translocase
SD85_RS13570	COG0343	queuine tRNA-ribosyltransferase activity
SD85_RS13575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SD85_RS13585	COG2255	four-way junction helicase activity
SD85_RS13590	COG0632	four-way junction helicase activity
SD85_RS13600	COG2814	Major facilitator Superfamily
SD85_RS13605	COG0673	inositol 2-dehydrogenase activity
SD85_RS13610	COG2112	serine threonine protein kinase
SD85_RS13620	COG1115	amino acid carrier protein
SD85_RS13625	COG0217	transcriptional regulatory protein
SD85_RS13635	COG1388	LysM domain
SD85_RS13640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SD85_RS13645	COG0157	Belongs to the NadC ModD family
SD85_RS13650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SD85_RS13655	COG1104	cysteine desulfurase activity
SD85_RS13660	COG1827	regulation of RNA biosynthetic process
SD85_RS13665	COG0077	Prephenate dehydratase
SD85_RS13670	COG4492	Belongs to the UPF0735 family
SD85_RS13675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SD85_RS13680	COG3290	protein histidine kinase activity
SD85_RS13690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SD85_RS13695	COG2868	ribosomal protein
SD85_RS13700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SD85_RS13705	COG1994	Peptidase M50
SD85_RS13710	COG0739	heme binding
SD85_RS13715	COG2894	cell division
SD85_RS13720	COG0850	regulation of cytokinetic process
SD85_RS13725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SD85_RS13735	COG1077	Cell shape determining protein MreB Mrl
SD85_RS13740	COG2003	Belongs to the UPF0758 family
SD85_RS13745	COG0424	maF-like protein
SD85_RS13755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SD85_RS13760	COG0285	dihydrofolate synthase activity
SD85_RS13765	COG0525	valine-tRNA ligase activity
SD85_RS13775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SD85_RS13780	COG1388	LysM domain
SD85_RS13785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SD85_RS13790	COG0113	porphobilinogen synthase activity
SD85_RS13795	COG1587	Uroporphyrinogen-III synthase
SD85_RS13800	COG0181	hydroxymethylbilane synthase activity
SD85_RS13805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SD85_RS13810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SD85_RS13820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SD85_RS13825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SD85_RS13830	COG1067	ATP-dependent peptidase activity
SD85_RS13830	COG0470	DNA polymerase III
SD85_RS13835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SD85_RS13840	COG0544	peptidyl-prolyl cis-trans isomerase activity
SD85_RS13845	COG1477	protein flavinylation
SD85_RS13845	COG0457	Tetratricopeptide repeat
SD85_RS13850	COG0066	3-isopropylmalate dehydratase activity
SD85_RS13855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SD85_RS13860	COG0473	3-isopropylmalate dehydrogenase activity
SD85_RS13865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SD85_RS13870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SD85_RS13875	COG0440	acetolactate synthase activity
SD85_RS13880	COG0028	Belongs to the TPP enzyme family
SD85_RS13890	COG0454	-acetyltransferase
SD85_RS13900	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
SD85_RS13910	COG0622	Phosphoesterase
SD85_RS13915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SD85_RS13920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SD85_RS13925	COG5401	PFAM Sporulation and spore germination
SD85_RS13930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SD85_RS13935	COG1846	Transcriptional regulator
SD85_RS13940	COG2197	response regulator
SD85_RS13945	COG0824	Thioesterase
SD85_RS13950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SD85_RS13955	COG1053	succinate dehydrogenase
SD85_RS13960	COG2009	succinate dehydrogenase
SD85_RS13970	COG1719	4-vinyl reductase, 4VR
SD85_RS13975	COG0527	aspartate kinase activity
SD85_RS13980	COG0322	excinuclease ABC activity
SD85_RS13985	COG3118	belongs to the thioredoxin family
SD85_RS13990	COG3534	alpha-L-arabinofuranosidase
SD85_RS13995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SD85_RS14000	COG2086	electron transfer activity
SD85_RS14005	COG1024	Enoyl-CoA hydratase
SD85_RS14010	COG1309	transcriptional regulator
SD85_RS14015	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS14020	COG3766	membrane
SD85_RS14025	COG1193	negative regulation of DNA recombination
SD85_RS14030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SD85_RS14030	COG1796	DNA polymerase
SD85_RS14035	COG1286	toxin biosynthetic process
SD85_RS14040	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SD85_RS14045	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SD85_RS14050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD85_RS14050	COG0072	phenylalanine-tRNA ligase activity
SD85_RS14055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SD85_RS14060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SD85_RS14070	COG0584	glycerophosphoryl diester phosphodiesterase
SD85_RS14075	COG0277	FAD linked oxidase domain protein
SD85_RS14080	COG0247	lactate metabolic process
SD85_RS14085	COG0346	lactoylglutathione lyase activity
SD85_RS14090	COG1966	Carbon starvation protein
SD85_RS14105	COG1695	Transcriptional regulator
SD85_RS14110	COG3534	alpha-L-arabinofuranosidase
SD85_RS14115	COG0395	ABC-type sugar transport system, permease component
SD85_RS14120	COG1175	transmembrane transport
SD85_RS14125	COG1653	transport
SD85_RS14130	COG0371	Dehydrogenase
SD85_RS14135	COG0647	UMP catabolic process
SD85_RS14140	COG0235	Class ii aldolase
SD85_RS14145	COG1069	ribulokinase activity
SD85_RS14150	COG2160	L-arabinose isomerase activity
SD85_RS14155	COG3507	Belongs to the glycosyl hydrolase 43 family
SD85_RS14160	COG1363	Peptidase, m42
SD85_RS14170	COG3326	Membrane
SD85_RS14175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SD85_RS14180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SD85_RS14185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SD85_RS14200	COG1346	cytolysis
SD85_RS14205	COG1380	Effector of murein hydrolase LrgA
SD85_RS14210	COG3279	Response regulator of the LytR AlgR family
SD85_RS14215	COG3275	phosphorelay sensor kinase activity
SD85_RS14220	COG1011	Hydrolase
SD85_RS14225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SD85_RS14235	COG0398	Pfam SNARE associated Golgi protein
SD85_RS14240	COG1484	DNA-dependent DNA replication
SD85_RS14245	COG3611	Membrane attachment protein
SD85_RS14250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SD85_RS14255	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SD85_RS14260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SD85_RS14265	COG1733	regulation of RNA biosynthetic process
SD85_RS14270	COG2814	Major facilitator Superfamily
SD85_RS14275	COG0656	L-ascorbic acid biosynthetic process
SD85_RS14280	COG0237	dephospho-CoA kinase activity
SD85_RS14295	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SD85_RS14300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SD85_RS14300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SD85_RS14305	COG5002	protein histidine kinase activity
SD85_RS14310	COG0745	RESPONSE REGULATOR receiver
SD85_RS14315	COG0039	L-malate dehydrogenase activity
SD85_RS14320	COG0538	isocitrate dehydrogenase activity
SD85_RS14325	COG0372	Belongs to the citrate synthase family
SD85_RS14330	COG2707	UPF0756 membrane protein
SD85_RS14335	COG0628	permease
SD85_RS14340	COG3030	protein affecting phage T7 exclusion by the F plasmid
SD85_RS14345	COG0469	pyruvate kinase activity
SD85_RS14350	COG0205	6-phosphofructokinase activity
SD85_RS14355	COG0825	malonyl-CoA metabolic process
SD85_RS14360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SD85_RS14365	COG0281	malic enzyme
SD85_RS14370	COG0587	DNA-directed DNA polymerase activity
SD85_RS14390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SD85_RS14400	COG4109	DRTGG domain
SD85_RS14405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SD85_RS14410	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS14420	COG0165	Argininosuccinate lyase
SD85_RS14425	COG0137	argininosuccinate synthase activity
SD85_RS14430	COG0521	Mo-molybdopterin cofactor biosynthetic process
SD85_RS14435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SD85_RS14440	COG0827	DNA restriction-modification system
SD85_RS14445	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SD85_RS14450	COG3874	Sporulation protein YtfJ
SD85_RS14460	COG1714	RDD family
SD85_RS14465	COG0616	signal peptide processing
SD85_RS14470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SD85_RS14475	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SD85_RS14480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD85_RS14490	COG0301	tRNA thio-modification
SD85_RS14495	COG1104	cysteine desulfurase activity
SD85_RS14500	COG1114	Component of the transport system for branched-chain amino acids
SD85_RS14505	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SD85_RS14510	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SD85_RS14515	COG1309	transcriptional regulator
SD85_RS14520	COG1956	GAF domain-containing protein
SD85_RS14525	COG2203	Gaf domain
SD85_RS14525	COG2199	diguanylate cyclase activity
SD85_RS14530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SD85_RS14540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SD85_RS14545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SD85_RS14550	COG0454	-acetyltransferase
SD85_RS14555	COG0517	IMP dehydrogenase activity
SD85_RS14560	COG0123	including yeast histone deacetylase and acetoin utilization protein
SD85_RS14565	COG1360	Flagellar Motor Protein
SD85_RS14570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SD85_RS14575	COG1609	Transcriptional regulator
SD85_RS14580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SD85_RS14580	COG1605	Chorismate mutase
SD85_RS14585	COG3118	belongs to the thioredoxin family
SD85_RS14590	COG4980	gas vesicle protein
SD85_RS14595	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SD85_RS14600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SD85_RS14605	COG1674	ftsk spoiiie
SD85_RS14610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SD85_RS14615	COG4848	Belongs to the UPF0354 family
SD85_RS14620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS14630	COG1363	Peptidase, m42
SD85_RS14635	COG5584	Small secreted protein
SD85_RS14640	COG0281	malic enzyme
SD85_RS14645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS14650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SD85_RS14660	COG0510	thiamine kinase activity
SD85_RS14665	COG1523	belongs to the glycosyl hydrolase 13 family
SD85_RS14670	COG1597	lipid kinase activity
SD85_RS14680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SD85_RS14685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SD85_RS14690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD85_RS14695	COG2252	PERMEase
SD85_RS14700	COG4473	ABC transporter
SD85_RS14705	COG1131	(ABC) transporter
SD85_RS14710	COG1349	DNA-binding transcription factor activity
SD85_RS14715	COG1187	pseudouridine synthase activity
SD85_RS14720	COG2244	polysaccharide biosynthetic process
SD85_RS14725	COG2081	HI0933 family
SD85_RS14730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SD85_RS14740	COG5578	integral membrane protein
SD85_RS14745	COG0673	inositol 2-dehydrogenase activity
SD85_RS14750	COG1653	transport
SD85_RS14755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SD85_RS14760	COG4209	transmembrane transport
SD85_RS14765	COG2207	Transcriptional regulator
SD85_RS14770	COG1653	transport
SD85_RS14775	COG0395	ABC-type sugar transport system, permease component
SD85_RS14780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD85_RS14785	COG2124	cytochrome p450
SD85_RS14790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SD85_RS14800	COG0156	8-amino-7-oxononanoate synthase activity
SD85_RS14805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SD85_RS14820	COG1073	alpha beta
SD85_RS14825	COG1609	Transcriptional regulator
SD85_RS14830	COG1653	transport
SD85_RS14835	COG1175	transmembrane transport
SD85_RS14840	COG0395	ABC-type sugar transport system, permease component
SD85_RS14845	COG1486	melibiose metabolic process
SD85_RS14850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SD85_RS14855	COG0495	leucyl-tRNA aminoacylation
SD85_RS14865	COG2202	Pas domain
SD85_RS14865	COG1366	Belongs to the anti-sigma-factor antagonist family
SD85_RS14870	COG2814	Major facilitator Superfamily
SD85_RS14875	COG2433	Pfam Transposase IS66
SD85_RS14880	COG0577	efflux transmembrane transporter activity
SD85_RS14885	COG1136	(ABC) transporter
SD85_RS14890	COG2205	protein histidine kinase activity
SD85_RS14895	COG0745	RESPONSE REGULATOR receiver
SD85_RS14900	COG0577	efflux transmembrane transporter activity
SD85_RS14905	COG1136	(ABC) transporter
SD85_RS14920	COG1131	(ABC) transporter
SD85_RS14925	COG1725	Transcriptional regulator
SD85_RS14940	COG1242	4 iron, 4 sulfur cluster binding
SD85_RS14945	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SD85_RS14955	COG2267	carboxylic ester hydrolase activity
SD85_RS14960	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SD85_RS14965	COG1113	amino acid transport
SD85_RS14970	COG0367	asparagine synthase
SD85_RS14975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SD85_RS14980	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SD85_RS14990	COG1506	peptidase
SD85_RS14995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SD85_RS15000	COG1116	anion transmembrane transporter activity
SD85_RS15005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SD85_RS15010	COG2801	Transposase and inactivated derivatives
SD85_RS15020	COG0494	nUDIX hydrolase
SD85_RS15025	COG4824	toxin secretion phage lysis holin
SD85_RS15030	COG0783	Belongs to the Dps family
SD85_RS15045	COG1854	S-ribosylhomocysteine lyase activity
SD85_RS15050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SD85_RS15055	COG0288	reversible hydration of carbon dioxide
SD85_RS15060	COG0254	rRNA binding
SD85_RS15065	COG1271	oxidase subunit
SD85_RS15070	COG1294	oxidase, subunit
SD85_RS15080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD85_RS15085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SD85_RS15085	COG1321	iron dependent repressor
SD85_RS15090	COG1121	(ABC) transporter
SD85_RS15095	COG0803	Belongs to the bacterial solute-binding protein 9 family
SD85_RS15100	COG4948	Mandelate Racemase Muconate Lactonizing
SD85_RS15105	COG0318	PFAM AMP-dependent synthetase and ligase
SD85_RS15110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SD85_RS15115	COG0596	Alpha beta hydrolase
SD85_RS15120	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SD85_RS15125	COG1169	isochorismate synthase
SD85_RS15130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SD85_RS15135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SD85_RS15140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD85_RS15145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SD85_RS15150	COG0438	transferase activity, transferring glycosyl groups
SD85_RS15160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SD85_RS15165	COG0438	transferase activity, transferring glycosyl groups
SD85_RS15170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SD85_RS15175	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SD85_RS15180	COG0058	SHG alpha-glucan phosphorylase activity
SD85_RS15185	COG0297	glycogen (starch) synthase activity
SD85_RS15190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SD85_RS15195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SD85_RS15200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SD85_RS15330	COG3859	Proton-coupled thiamine transporter YuaJ
SD85_RS15335	COG1247	-acetyltransferase
SD85_RS15340	COG2268	Band 7 protein
SD85_RS15345	COG1585	Membrane protein implicated in regulation of membrane protease activity
SD85_RS15350	COG2318	DinB family
SD85_RS15360	COG1454	alcohol dehydrogenase
SD85_RS15365	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS15370	COG1510	regulation of RNA biosynthetic process
SD85_RS15380	COG0569	domain protein
SD85_RS15385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SD85_RS15390	COG4682	membrane
SD85_RS15395	COG1705	Flagellar rod assembly protein muramidase FlgJ
SD85_RS15400	COG0477	Major facilitator Superfamily
SD85_RS15405	COG5553	Cysteine dioxygenase type I
SD85_RS15415	COG1968	undecaprenyl-diphosphatase activity
SD85_RS15420	COG0628	permease
SD85_RS15425	COG0673	inositol 2-dehydrogenase activity
SD85_RS15430	COG4806	L-rhamnose isomerase
SD85_RS15435	COG3254	rhamnose metabolic process
SD85_RS15440	COG1070	Carbohydrate kinase
SD85_RS15445	COG1349	DNA-binding transcription factor activity
SD85_RS15450	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS15450	COG3347	Dehydrogenase
SD85_RS15455	COG0840	transmembrane signaling receptor activity
SD85_RS15460	COG0840	transmembrane signaling receptor activity
SD85_RS15465	COG0840	transmembrane signaling receptor activity
SD85_RS15470	COG0840	transmembrane signaling receptor activity
SD85_RS15485	COG2070	2-Nitropropane dioxygenase
SD85_RS15490	COG0432	Pfam Uncharacterised protein family UPF0047
SD85_RS15495	COG0366	Alpha amylase catalytic
SD85_RS15505	COG2801	Transposase and inactivated derivatives
SD85_RS15510	COG1253	flavin adenine dinucleotide binding
SD85_RS15515	COG2738	Putative neutral zinc metallopeptidase
SD85_RS15530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SD85_RS15545	COG0166	Belongs to the GPI family
SD85_RS15550	COG1979	alcohol dehydrogenase
SD85_RS15555	COG1979	alcohol dehydrogenase
SD85_RS15560	COG2155	Conserved Protein
SD85_RS15565	COG1098	S1 RNA binding domain
SD85_RS15570	COG0436	Aminotransferase
SD85_RS15575	COG1522	sequence-specific DNA binding
SD85_RS15580	COG2267	carboxylic ester hydrolase activity
SD85_RS15590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SD85_RS15595	COG2205	protein histidine kinase activity
SD85_RS15605	COG5018	Exonuclease
SD85_RS15615	COG2814	Major facilitator Superfamily
SD85_RS15620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD85_RS15625	COG3011	Protein conserved in bacteria
SD85_RS15635	COG3290	protein histidine kinase activity
SD85_RS15640	COG4565	transcriptional regulatory protein
SD85_RS15645	COG3493	citrate carrier protein
SD85_RS15655	COG2111	Na H antiporter
SD85_RS15655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SD85_RS15660	COG2111	Na H antiporter
SD85_RS15665	COG1006	Multisubunit Na H antiporter MnhC subunit
SD85_RS15670	COG0651	ATP synthesis coupled electron transport
SD85_RS15675	COG1863	multisubunit Na H antiporter MnhE subunit
SD85_RS15680	COG2212	antiporter activity
SD85_RS15685	COG1320	monovalent cation:proton antiporter activity
SD85_RS15690	COG2050	protein possibly involved in aromatic compounds catabolism
SD85_RS15695	COG2197	response regulator
SD85_RS15700	COG4585	Histidine kinase
SD85_RS15710	COG0142	geranyltranstransferase activity
SD85_RS15725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
SD85_RS15730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SD85_RS15735	COG1335	isochorismatase
SD85_RS15740	COG5506	Protein of unknown function (DUF1694)
SD85_RS15755	COG0628	permease
SD85_RS15770	COG1418	mRNA catabolic process
SD85_RS15775	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS15785	COG1511	domain protein
SD85_RS15790	COG1674	ftsk spoiiie
SD85_RS15790	COG0433	COG0433 Predicted ATPase
SD85_RS15795	COG4499	WXG100 protein secretion system (Wss), protein YukC
SD85_RS15800	COG5417	Belongs to the EsaB family
SD85_RS15805	COG4842	Belongs to the WXG100 family
SD85_RS15810	COG2508	Transcriptional regulator
SD85_RS15810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SD85_RS15815	COG0686	Belongs to the AlaDH PNT family
SD85_RS15820	COG5634	Uncharacterized conserved protein (DUF2278)
SD85_RS15825	COG3251	PFAM MbtH domain protein
SD85_RS15830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS15835	COG1535	isochorismatase
SD85_RS15835	COG3433	isochorismatase activity
SD85_RS15840	COG1021	2,3-dihydroxybenzoate-AMP ligase
SD85_RS15845	COG1169	isochorismate synthase
SD85_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS15855	COG2819	hydrolase of the alpha beta superfamily
SD85_RS15860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SD85_RS15865	COG1268	BioY protein
SD85_RS15870	COG2056	Na+-H+ antiporter family
SD85_RS15875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SD85_RS15880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SD85_RS15885	COG3584	3D domain protein
SD85_RS15900	COG1252	NADH dehydrogenase
SD85_RS15905	COG0492	ferredoxin-NADP+ reductase activity
SD85_RS15915	COG0516	GMP reductase activity
SD85_RS15930	COG1131	(ABC) transporter
SD85_RS15950	COG0456	acetyltransferase
SD85_RS15960	COG0316	Belongs to the HesB IscA family
SD85_RS15965	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SD85_RS15970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SD85_RS15975	COG4844	belongs to the
SD85_RS15980	COG1252	NADH dehydrogenase
SD85_RS15985	COG4837	Protein of unknown function (DUF1462)
SD85_RS15990	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SD85_RS15995	COG0823	Involved in the tonB-independent uptake of proteins
SD85_RS15995	COG4946	Tricorn protease homolog
SD85_RS15995	COG1506	peptidase
SD85_RS16000	COG0083	homoserine kinase activity
SD85_RS16005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SD85_RS16010	COG0460	homoserine dehydrogenase
SD85_RS16015	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SD85_RS16020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SD85_RS16025	COG0647	UMP catabolic process
SD85_RS16030	COG2445	Protein of unknown function DUF86
SD85_RS16035	COG4470	Protein conserved in bacteria
SD85_RS16045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SD85_RS16050	COG0739	heme binding
SD85_RS16060	COG3377	Domain of unknown function (DUF1805)
SD85_RS16065	COG0737	Belongs to the 5'-nucleotidase family
SD85_RS16070	COG0730	response to heat
SD85_RS16075	COG1801	Protein of unknown function DUF72
SD85_RS16085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SD85_RS16090	COG2508	Transcriptional regulator
SD85_RS16095	COG2233	PERMEase
SD85_RS16100	COG2233	PERMEase
SD85_RS16105	COG3648	Uricase
SD85_RS16105	COG3195	allantoin biosynthetic process
SD85_RS16110	COG2351	hydroxyisourate hydrolase activity
SD85_RS16125	COG2080	2 iron, 2 sulfur cluster binding
SD85_RS16130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SD85_RS16135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SD85_RS16140	COG2068	MobA-Related Protein
SD85_RS16145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SD85_RS16150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SD85_RS16155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SD85_RS16170	COG2356	endonuclease I
SD85_RS16175	COG3842	ATPase activity
SD85_RS16180	COG2188	Transcriptional regulator
SD85_RS16185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD85_RS16190	COG0395	ABC-type sugar transport system, permease component
SD85_RS16195	COG1175	transmembrane transport
SD85_RS16200	COG1653	transport
SD85_RS16205	COG2222	sugar isomerase
SD85_RS16210	COG0322	excinuclease ABC activity
SD85_RS16215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SD85_RS16230	COG0346	lactoylglutathione lyase activity
SD85_RS16235	COG0640	Transcriptional regulator
SD85_RS16240	COG0719	Fe-S assembly protein
SD85_RS16245	COG0822	iron-sulfur transferase activity
SD85_RS16250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SD85_RS16255	COG0719	Fe-S assembly protein
SD85_RS16260	COG0396	ATPase activity
SD85_RS16270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SD85_RS16275	COG1464	Belongs to the NlpA lipoprotein family
SD85_RS16280	COG2011	ABC-type metal ion transport system permease component
SD85_RS16285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SD85_RS16295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SD85_RS16300	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SD85_RS16310	COG0509	glycine decarboxylation via glycine cleavage system
SD85_RS16315	COG1393	Belongs to the ArsC family
SD85_RS16320	COG1960	acyl-CoA dehydrogenase activity
SD85_RS16325	COG0183	Belongs to the thiolase family
SD85_RS16330	COG1024	Enoyl-CoA hydratase
SD85_RS16330	COG1250	3-hydroxyacyl-CoA dehydrogenase
SD85_RS16340	COG0506	proline dehydrogenase activity
SD85_RS16350	COG5577	PFAM Coat F domain
SD85_RS16355	COG1846	Transcriptional regulator
SD85_RS16360	COG0477	Major facilitator Superfamily
SD85_RS16365	COG1942	4-Oxalocrotonate Tautomerase
SD85_RS16370	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS16375	COG0583	DNA-binding transcription factor activity
SD85_RS16385	COG1120	ATPase activity
SD85_RS16400	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS16405	COG0783	Belongs to the Dps family
SD85_RS16410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD85_RS16415	COG0745	RESPONSE REGULATOR receiver
SD85_RS16420	COG2770	Histidine kinase
SD85_RS16420	COG2205	protein histidine kinase activity
SD85_RS16430	COG1309	transcriptional regulator
SD85_RS16435	COG0114	fumarate hydratase activity
SD85_RS16445	COG0697	spore germination
SD85_RS16450	COG0814	amino acid
SD85_RS16460	COG2197	response regulator
SD85_RS16465	COG4585	Histidine kinase
SD85_RS16470	COG4758	membrane
SD85_RS16475	COG3595	metallopeptidase activity
SD85_RS16480	COG1842	Phage shock protein A
SD85_RS16485	COG4758	membrane
SD85_RS16490	COG2814	Major facilitator Superfamily
SD85_RS16495	COG2096	Adenosyltransferase
SD85_RS16500	COG1120	ATPase activity
SD85_RS16505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS16510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS16520	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS16525	COG3386	PFAM SMP-30 Gluconolaconase
SD85_RS16530	COG2205	protein histidine kinase activity
SD85_RS16535	COG0745	RESPONSE REGULATOR receiver
SD85_RS16545	COG1191	sigma factor activity
SD85_RS16555	COG2140	Oxalate decarboxylase
SD85_RS16565	COG0577	efflux transmembrane transporter activity
SD85_RS16570	COG1136	(ABC) transporter
SD85_RS16575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SD85_RS16580	COG1120	ATPase activity
SD85_RS16585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS16590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SD85_RS16595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS16610	COG0531	amino acid
SD85_RS16620	COG1988	membrane-bound metal-dependent
SD85_RS16625	COG1368	sulfuric ester hydrolase activity
SD85_RS16630	COG1910	domain protein
SD85_RS16635	COG0725	ABC transporter, periplasmic molybdate-binding protein
SD85_RS16640	COG4149	molybdate abc transporter
SD85_RS16645	COG0656	L-ascorbic acid biosynthetic process
SD85_RS16655	COG0025	NhaP-type Na H and K H
SD85_RS16660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SD85_RS16665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SD85_RS16670	COG3973	AAA domain
SD85_RS16675	COG2860	membrane
SD85_RS16680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SD85_RS16685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SD85_RS16690	COG2217	Heavy metal translocating P-type atpase
SD85_RS16695	COG2217	Heavy metal translocating P-type atpase
SD85_RS16700	COG2608	mercury ion transmembrane transporter activity
SD85_RS16705	COG1937	Protein conserved in bacteria
SD85_RS16710	COG0673	inositol 2-dehydrogenase activity
SD85_RS16715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SD85_RS16720	COG1289	transmembrane transporter activity
SD85_RS16725	COG1802	Transcriptional regulator
SD85_RS16730	COG0697	spore germination
SD85_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS16760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SD85_RS16765	COG0557	exoribonuclease II activity
SD85_RS16770	COG1647	Serine aminopeptidase, S33
SD85_RS16775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SD85_RS16780	COG0596	Alpha beta hydrolase
SD85_RS16785	COG1476	TRANSCRIPTIONal
SD85_RS16790	COG1396	sequence-specific DNA binding
SD85_RS16795	COG1396	sequence-specific DNA binding
SD85_RS16800	COG1733	regulation of RNA biosynthetic process
SD85_RS16825	COG1131	(ABC) transporter
SD85_RS16855	COG1174	glycine betaine transport
SD85_RS16860	COG1732	Glycine betaine
SD85_RS16865	COG1174	glycine betaine transport
SD85_RS16870	COG1125	glycine betaine transport
SD85_RS16870	COG0517	IMP dehydrogenase activity
SD85_RS16875	COG1510	regulation of RNA biosynthetic process
SD85_RS16880	COG2801	Transposase and inactivated derivatives
SD85_RS16890	COG1174	glycine betaine transport
SD85_RS16895	COG1732	Glycine betaine
SD85_RS16900	COG1174	glycine betaine transport
SD85_RS16905	COG1125	glycine betaine transport
SD85_RS16905	COG0517	IMP dehydrogenase activity
SD85_RS16910	COG1510	regulation of RNA biosynthetic process
SD85_RS16920	COG3064	Membrane
SD85_RS16925	COG4640	response to antibiotic
SD85_RS16930	COG0456	acetyltransferase
SD85_RS16940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SD85_RS16945	COG0149	triose-phosphate isomerase activity
SD85_RS16950	COG0126	phosphoglycerate kinase activity
SD85_RS16960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SD85_RS16965	COG2390	Transcriptional regulator
SD85_RS16970	COG2814	Major facilitator Superfamily
SD85_RS16975	COG1609	Transcriptional regulator
SD85_RS16980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD85_RS16985	COG0697	spore germination
SD85_RS16990	COG1113	amino acid transport
SD85_RS16995	COG3858	chitin binding
SD85_RS17000	COG1556	Lactate utilization protein
SD85_RS17005	COG1139	Iron-sulfur cluster binding protein
SD85_RS17010	COG0247	lactate metabolic process
SD85_RS17025	COG2197	response regulator
SD85_RS17030	COG4585	Histidine kinase
SD85_RS17035	COG0842	Transport permease protein
SD85_RS17040	COG1131	(ABC) transporter
SD85_RS17045	COG0596	Alpha beta hydrolase
SD85_RS17050	COG2208	phosphoserine phosphatase activity
SD85_RS17060	COG1874	Beta-galactosidase
SD85_RS17065	COG3833	ABC-type maltose transport systems, permease component
SD85_RS17070	COG1175	transmembrane transport
SD85_RS17075	COG2182	Extracellular solute-binding protein
SD85_RS17080	COG1609	Transcriptional regulator
SD85_RS17085	COG2186	Transcriptional regulator
SD85_RS17090	COG1620	l-lactate permease
SD85_RS17095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SD85_RS17105	COG5039	Polysaccharide pyruvyl transferase
SD85_RS17110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD85_RS17115	COG0110	maltose O-acetyltransferase activity
SD85_RS17120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SD85_RS17125	COG2244	polysaccharide biosynthetic process
SD85_RS17130	COG1216	Glycosyl transferase, family 2
SD85_RS17135	COG5039	Polysaccharide pyruvyl transferase
SD85_RS17140	COG1216	Glycosyl transferase, family 2
SD85_RS17150	COG0438	transferase activity, transferring glycosyl groups
SD85_RS17155	COG1215	transferase activity, transferring glycosyl groups
SD85_RS17160	COG0438	transferase activity, transferring glycosyl groups
SD85_RS17165	COG1086	Polysaccharide biosynthesis protein
SD85_RS17170	COG0489	protein tyrosine kinase activity
SD85_RS17175	COG3944	biosynthesis protein
SD85_RS17180	COG1396	sequence-specific DNA binding
SD85_RS17185	COG2272	Belongs to the type-B carboxylesterase lipase family
SD85_RS17195	COG3479	Phenolic acid decarboxylase
SD85_RS17205	COG1794	racemase activity, acting on amino acids and derivatives
SD85_RS17210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SD85_RS17215	COG1621	beta-fructofuranosidase activity
SD85_RS17220	COG1621	beta-fructofuranosidase activity
SD85_RS17225	COG0531	amino acid
SD85_RS17230	COG1309	transcriptional regulator
SD85_RS17235	COG2076	Multidrug Resistance protein
SD85_RS17240	COG2076	Multidrug Resistance protein
SD85_RS17260	COG1611	Belongs to the LOG family
SD85_RS17265	COG1694	Mazg nucleotide pyrophosphohydrolase
SD85_RS17270	COG0659	secondary active sulfate transmembrane transporter activity
SD85_RS17275	COG0288	reversible hydration of carbon dioxide
SD85_RS17280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SD85_RS17285	COG0577	efflux transmembrane transporter activity
SD85_RS17290	COG1136	(ABC) transporter
SD85_RS17295	COG5002	protein histidine kinase activity
SD85_RS17300	COG0745	RESPONSE REGULATOR receiver
SD85_RS17310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SD85_RS17315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS17320	COG1481	regulation of sporulation
SD85_RS17325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SD85_RS17330	COG1660	Displays ATPase and GTPase activities
SD85_RS17335	COG1051	belongs to the nudix hydrolase family
SD85_RS17340	COG0492	ferredoxin-NADP+ reductase activity
SD85_RS17345	COG3883	PFAM NLP P60 protein
SD85_RS17345	COG0791	NLP P60 protein
SD85_RS17350	COG0457	Tetratricopeptide repeat
SD85_RS17355	COG1132	(ABC) transporter
SD85_RS17375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SD85_RS17375	COG0140	phosphoribosyl-ATP diphosphatase activity
SD85_RS17380	COG0107	imidazoleglycerol-phosphate synthase activity
SD85_RS17385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SD85_RS17390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SD85_RS17395	COG0131	Imidazoleglycerol-phosphate dehydratase
SD85_RS17400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SD85_RS17405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SD85_RS17410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SD85_RS17415	COG4990	cell redox homeostasis
SD85_RS17420	COG5297	Belongs to the glycosyl hydrolase family 6
SD85_RS17425	COG0110	maltose O-acetyltransferase activity
SD85_RS17430	COG0546	phosphoglycolate phosphatase activity
SD85_RS17435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SD85_RS17440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SD85_RS17445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SD85_RS17450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SD85_RS17455	COG0363	glucosamine-6-phosphate deaminase activity
SD85_RS17460	COG2188	Transcriptional regulator
SD85_RS17465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SD85_RS17470	COG1846	Transcriptional regulator
SD85_RS17475	COG2124	cytochrome p450
SD85_RS17485	COG1846	Transcriptional regulator
SD85_RS17490	COG2814	Major facilitator Superfamily
SD85_RS17495	COG1950	PFAM Membrane protein of
SD85_RS17500	COG1983	PspC domain protein
SD85_RS17505	COG3595	metallopeptidase activity
SD85_RS17520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SD85_RS17530	COG4897	Protein conserved in bacteria
SD85_RS17535	COG3848	Pyruvate phosphate dikinase
SD85_RS17535	COG0574	Belongs to the PEP-utilizing enzyme family
SD85_RS17540	COG1309	transcriptional regulator
SD85_RS17545	COG2814	Major facilitator Superfamily
SD85_RS17550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD85_RS17560	COG3409	Peptidoglycan-binding domain 1 protein
SD85_RS17560	COG0793	Belongs to the peptidase S41A family
SD85_RS17565	COG2177	Part of the ABC transporter FtsEX involved in
SD85_RS17570	COG2884	Cell division ATP-binding protein ftsE
SD85_RS17575	COG2010	Cytochrome c
SD85_RS17580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS17585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SD85_RS17590	COG0653	protein targeting
SD85_RS17595	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SD85_RS17610	COG1516	flagellar protein fliS
SD85_RS17615	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SD85_RS17620	COG1334	flagellar protein FlaG
SD85_RS17625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SD85_RS17630	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SD85_RS17635	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
SD85_RS17645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SD85_RS17650	COG4786	Flagellar basal body rod
SD85_RS17650	COG1256	bacterial-type flagellum assembly
SD85_RS17655	COG3418	PFAM FlgN family protein
SD85_RS17660	COG2747	anti-sigma28 factor FlgM
SD85_RS17670	COG1040	competence protein
SD85_RS17680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SD85_RS17685	COG1307	EDD domain protein, DegV family
SD85_RS17690	COG2197	response regulator
SD85_RS17695	COG4585	Histidine kinase
SD85_RS17700	COG1739	Uncharacterized protein family UPF0029
SD85_RS17705	COG1316	TRANSCRIPTIONal
SD85_RS17710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SD85_RS17715	COG0438	transferase activity, transferring glycosyl groups
SD85_RS17720	COG1215	transferase activity, transferring glycosyl groups
SD85_RS17725	COG3206	protein involved in exopolysaccharide biosynthesis
SD85_RS17730	COG3307	-O-antigen
SD85_RS17735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD85_RS17740	COG0438	transferase activity, transferring glycosyl groups
SD85_RS17740	COG0297	glycogen (starch) synthase activity
SD85_RS17745	COG2244	polysaccharide biosynthetic process
SD85_RS17760	COG2247	cell wall binding repeat
SD85_RS17760	COG0860	N-Acetylmuramoyl-L-alanine amidase
SD85_RS17765	COG2247	cell wall binding repeat
SD85_RS17765	COG2385	sporulation resulting in formation of a cellular spore
SD85_RS17775	COG1316	TRANSCRIPTIONal
SD85_RS17780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SD85_RS17800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SD85_RS17805	COG1134	teichoic acid transport
SD85_RS17810	COG1682	transport, permease protein
SD85_RS17825	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SD85_RS17825	COG1215	transferase activity, transferring glycosyl groups
SD85_RS17830	COG0463	Glycosyl transferase, family 2
SD85_RS17875	COG4193	domain, Protein
SD85_RS17880	COG1482	cell wall glycoprotein biosynthetic process
SD85_RS17890	COG0697	spore germination
SD85_RS17895	COG0814	amino acid
SD85_RS17905	COG2814	Major facilitator Superfamily
SD85_RS17910	COG1316	TRANSCRIPTIONal
SD85_RS17915	COG0561	phosphatase activity
SD85_RS17920	COG0791	NLP P60 protein
SD85_RS17930	COG2843	Capsule synthesis protein
SD85_RS17940	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SD85_RS17945	COG1609	Transcriptional regulator
SD85_RS17950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD85_RS17955	COG1869	D-ribose catabolic process
SD85_RS17960	COG1129	ABC transporter
SD85_RS17965	COG1172	Belongs to the binding-protein-dependent transport system permease family
SD85_RS17970	COG1879	ABC-type sugar transport system periplasmic component
SD85_RS17975	COG3103	Sh3 type 3 domain protein
SD85_RS17985	COG2249	NAD(P)H dehydrogenase (quinone) activity
SD85_RS17990	COG3527	Alpha-acetolactate decarboxylase
SD85_RS17995	COG0028	Belongs to the TPP enzyme family
SD85_RS18000	COG0583	DNA-binding transcription factor activity
SD85_RS18005	COG5337	Spore coat protein CotH
SD85_RS18015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SD85_RS18025	COG0405	Gamma-glutamyltransferase
SD85_RS18030	COG1522	sequence-specific DNA binding
SD85_RS18035	COG2059	Chromate
SD85_RS18040	COG2059	Chromate
SD85_RS18050	COG0655	NAD(P)H dehydrogenase (quinone) activity
SD85_RS18055	COG0583	DNA-binding transcription factor activity
SD85_RS18065	COG2207	Transcriptional regulator
SD85_RS18065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS18095	COG5444	nuclease activity
SD85_RS18110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SD85_RS18115	COG4464	protein tyrosine phosphatase activity
SD85_RS18120	COG0489	protein tyrosine kinase activity
SD85_RS18125	COG3944	biosynthesis protein
SD85_RS18135	COG4715	Zinc finger, swim domain protein
SD85_RS18140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SD85_RS18145	COG0561	phosphatase activity
SD85_RS18150	COG1349	DNA-binding transcription factor activity
SD85_RS18155	COG0629	single-stranded DNA binding
SD85_RS18170	COG3764	Sortase (surface protein transpeptidase)
SD85_RS18180	COG3279	Response regulator of the LytR AlgR family
SD85_RS18185	COG0745	RESPONSE REGULATOR receiver
SD85_RS18185	COG2972	Histidine kinase
SD85_RS18190	COG1970	mechanosensitive ion channel activity
SD85_RS18195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SD85_RS18200	COG0457	Tetratricopeptide repeat
SD85_RS18205	COG4786	Flagellar basal body rod
SD85_RS18210	COG4786	Flagellar basal body rod
SD85_RS18215	COG1077	Cell shape determining protein MreB Mrl
SD85_RS18220	COG1609	Transcriptional regulator
SD85_RS18225	COG1846	Transcriptional regulator
SD85_RS18230	COG2814	Major facilitator Superfamily
SD85_RS18235	COG3420	alginic acid biosynthetic process
SD85_RS18240	COG1953	Uracil, thiamine, allantoin
SD85_RS18245	COG0477	Major facilitator Superfamily
SD85_RS18250	COG1335	isochorismatase
SD85_RS18260	COG0004	ammonium transporteR
SD85_RS18265	COG0347	Belongs to the P(II) protein family
SD85_RS18270	COG0671	phosphoesterase, PA-phosphatase related
SD85_RS18280	COG0739	heme binding
SD85_RS18285	COG1247	-acetyltransferase
SD85_RS18305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SD85_RS18310	COG0789	Transcriptional regulator
SD85_RS18320	COG2910	NAD(P)H-binding
SD85_RS18325	COG1959	2 iron, 2 sulfur cluster binding
SD85_RS18330	COG0804	urea catabolic process
SD85_RS18335	COG0832	Belongs to the urease beta subunit family
SD85_RS18340	COG0831	urea catabolic process
SD85_RS18370	COG3237	CsbD-like
SD85_RS18375	COG1994	Peptidase M50
SD85_RS18380	COG0457	Tetratricopeptide repeat
SD85_RS18385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SD85_RS18390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SD85_RS18400	COG2304	oxidoreductase activity
SD85_RS18410	COG2304	oxidoreductase activity
SD85_RS18415	COG2385	sporulation resulting in formation of a cellular spore
SD85_RS18420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SD85_RS18430	COG4836	Membrane
SD85_RS18445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SD85_RS18450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SD85_RS18455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SD85_RS18460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SD85_RS18465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SD85_RS18480	COG0356	it plays a direct role in the translocation of protons across the membrane
SD85_RS18490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SD85_RS18495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SD85_RS18500	COG4475	Protein of unknown function (DUF436)
SD85_RS18505	COG0698	ribose 5-phosphate isomerase
SD85_RS18510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SD85_RS18515	COG1971	Probably functions as a manganese efflux pump
SD85_RS18520	COG0009	L-threonylcarbamoyladenylate synthase
SD85_RS18525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SD85_RS18545	COG2890	protein-(glutamine-N5) methyltransferase activity
SD85_RS18550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SD85_RS18555	COG0346	lactoylglutathione lyase activity
SD85_RS18560	COG0789	Transcriptional regulator
SD85_RS18565	COG0679	Auxin Efflux Carrier
SD85_RS18570	COG0281	malic enzyme
SD85_RS18575	COG1435	thymidine kinase activity
SD85_RS18585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SD85_RS18595	COG1494	fructose-1,6-bisphosphatase
SD85_RS18600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SD85_RS18605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SD85_RS18610	COG0191	fructose-bisphosphate aldolase activity
SD85_RS18615	COG2204	response regulator
SD85_RS18620	COG4821	SIS domain
SD85_RS18625	COG0504	CTP synthase activity
SD85_RS18630	COG3343	RNA polymerase activity
SD85_RS18635	COG1960	acyl-CoA dehydrogenase activity
SD85_RS18640	COG0247	lactate metabolic process
SD85_RS18640	COG2181	nitrate reductase activity
SD85_RS18645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SD85_RS18650	COG4294	response to UV
SD85_RS18660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SD85_RS18665	COG1132	(ABC) transporter
SD85_RS18670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SD85_RS18680	COG2181	nitrate reductase activity
SD85_RS18685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SD85_RS18690	COG1140	nitrate reductase beta subunit
SD85_RS18695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SD85_RS18700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD85_RS18710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SD85_RS18715	COG2223	nitrite transmembrane transporter activity
SD85_RS18720	COG0018	arginyl-trna synthetase
SD85_RS18725	COG4506	Protein conserved in bacteria
SD85_RS18735	COG0535	radical SAM domain protein
SD85_RS18745	COG1131	(ABC) transporter
SD85_RS18770	COG3391	amine dehydrogenase activity
SD85_RS18780	COG0457	Tetratricopeptide repeat
SD85_RS18790	COG0010	Belongs to the arginase family
SD85_RS18795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SD85_RS18800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SD85_RS18810	COG1994	Peptidase M50
SD85_RS18815	COG1942	4-Oxalocrotonate Tautomerase
SD85_RS18820	COG1846	Transcriptional regulator
SD85_RS18825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SD85_RS18835	COG3465	dGTPase activity
SD85_RS18840	COG1078	dGTPase activity
SD85_RS18845	COG4844	belongs to the
SD85_RS18855	COG0697	spore germination
SD85_RS18860	COG0095	Lipoate-protein ligase
SD85_RS18865	COG0583	DNA-binding transcription factor activity
SD85_RS18870	COG0280	phosphate acetyltransferase
SD85_RS18875	COG3253	May function as heme-dependent peroxidase
SD85_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS18885	COG0436	Aminotransferase
SD85_RS18890	COG2814	Major facilitator Superfamily
SD85_RS18895	COG0151	Belongs to the GarS family
SD85_RS18900	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS18905	COG1917	Cupin 2, conserved barrel domain protein
SD85_RS18910	COG0077	Prephenate dehydratase
SD85_RS18915	COG2814	Major facilitator Superfamily
SD85_RS18920	COG0833	amino acid
SD85_RS18925	COG4187	Peptidase family M20/M25/M40
SD85_RS18930	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS18935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SD85_RS18945	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SD85_RS18950	COG1091	dTDP-4-dehydrorhamnose reductase activity
SD85_RS18955	COG1088	dTDP-glucose 4,6-dehydratase activity
SD85_RS18960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SD85_RS18965	COG3980	spore coat polysaccharide biosynthesis protein
SD85_RS18970	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
SD85_RS18975	COG2089	acid synthase
SD85_RS18980	COG0456	acetyltransferase
SD85_RS18985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SD85_RS18990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SD85_RS18995	COG0463	Glycosyl transferase, family 2
SD85_RS19010	COG2363	Small membrane protein
SD85_RS19015	COG2233	PERMEase
SD85_RS19025	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS19030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SD85_RS19035	COG1216	Glycosyl transferase, family 2
SD85_RS19050	COG1695	Transcriptional regulator
SD85_RS19055	COG0351	phosphomethylpyrimidine kinase
SD85_RS19065	COG1621	beta-fructofuranosidase activity
SD85_RS19070	COG1263	PTS System
SD85_RS19070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS19075	COG2116	formate transmembrane transporter activity
SD85_RS19080	COG3711	transcriptional antiterminator
SD85_RS19090	COG1404	Belongs to the peptidase S8 family
SD85_RS19095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD85_RS19100	COG0778	Nitroreductase
SD85_RS19105	COG0772	Belongs to the SEDS family
SD85_RS19150	COG2261	transglycosylase associated protein
SD85_RS19155	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SD85_RS19160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SD85_RS19165	COG2246	polysaccharide biosynthetic process
SD85_RS19170	COG1309	transcriptional regulator
SD85_RS19180	COG3162	membrane
SD85_RS19185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SD85_RS19190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SD85_RS19195	COG2837	iron assimilation
SD85_RS19200	COG2822	iron ion transport
SD85_RS19205	COG0352	thiamine-phosphate diphosphorylase activity
SD85_RS19210	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SD85_RS19215	COG0583	DNA-binding transcription factor activity
SD85_RS19220	COG1380	Effector of murein hydrolase LrgA
SD85_RS19225	COG1346	cytolysis
SD85_RS19230	COG1131	(ABC) transporter
SD85_RS19255	COG1346	cytolysis
SD85_RS19260	COG2814	Major facilitator Superfamily
SD85_RS19265	COG4895	conserved protein (DUF2196)
SD85_RS19270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SD85_RS19275	COG0346	lactoylglutathione lyase activity
SD85_RS19285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SD85_RS19290	COG1404	Belongs to the peptidase S8 family
SD85_RS19295	COG1263	PTS System
SD85_RS19295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS19300	COG3711	transcriptional antiterminator
SD85_RS19305	COG1442	glycosyl transferase family 8
SD85_RS19310	COG5522	Integral membrane protein (intg_mem_TP0381)
SD85_RS19315	COG1846	Transcriptional regulator
SD85_RS19320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SD85_RS19325	COG2234	aminopeptidase activity
SD85_RS19330	COG2357	RelA SpoT domain protein
SD85_RS19340	COG1575	Belongs to the MenA family. Type 1 subfamily
SD85_RS19355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SD85_RS19360	COG1696	Membrane protein involved in D-alanine export
SD85_RS19365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SD85_RS19370	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SD85_RS19375	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SD85_RS19380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SD85_RS19385	COG1486	melibiose metabolic process
SD85_RS19390	COG1447	Phosphotransferase system cellobiose-specific component IIA
SD85_RS19395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SD85_RS19400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SD85_RS19405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SD85_RS19405	COG3711	transcriptional antiterminator
SD85_RS19410	COG2094	Belongs to the DNA glycosylase MPG family
SD85_RS19415	COG0753	catalase activity
SD85_RS19420	COG2814	Major facilitator Superfamily
SD85_RS19425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SD85_RS19430	COG1131	(ABC) transporter
SD85_RS19450	COG1595	DNA-templated transcription, initiation
SD85_RS19455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SD85_RS19460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SD85_RS19465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SD85_RS19470	COG4988	ABC transporter
SD85_RS19475	COG1294	oxidase, subunit
SD85_RS19480	COG1271	oxidase subunit
SD85_RS19485	COG3493	citrate carrier protein
SD85_RS19490	COG0501	Belongs to the peptidase M48B family
SD85_RS19500	COG0726	polysaccharide deacetylase
SD85_RS19515	COG3842	ATPase activity
SD85_RS19520	COG2508	Transcriptional regulator
SD85_RS19525	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS19530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SD85_RS19540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SD85_RS19550	COG2195	Cleaves the N-terminal amino acid of tripeptides
SD85_RS19565	COG4894	glucomannan catabolic process
SD85_RS19570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SD85_RS19575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SD85_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS19585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SD85_RS19590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SD85_RS19595	COG2610	gluconate transmembrane transporter activity
SD85_RS19605	COG0500	methyltransferase
SD85_RS19610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SD85_RS19625	COG0693	protein deglycase activity
SD85_RS19625	COG0753	catalase activity
SD85_RS19630	COG2851	Citrate transporter
SD85_RS19635	COG2323	membrane
SD85_RS19645	COG2723	6-phospho-beta-galactosidase activity
SD85_RS19650	COG2190	(PTS) system
SD85_RS19650	COG1263	PTS System
SD85_RS19650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS19655	COG3711	transcriptional antiterminator
SD85_RS19665	COG2270	Major facilitator Superfamily
SD85_RS19670	COG0513	Belongs to the DEAD box helicase family
SD85_RS19675	COG2755	lipolytic protein G-D-S-L family
SD85_RS19675	COG3401	FG-GAP repeat protein
SD85_RS19785	COG0697	spore germination
SD85_RS19795	COG0861	Integral membrane protein TerC family
SD85_RS19800	COG0589	response to stress
SD85_RS19805	COG2723	6-phospho-beta-galactosidase activity
SD85_RS19810	COG2190	(PTS) system
SD85_RS19810	COG1263	PTS System
SD85_RS19810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SD85_RS19845	COG5444	nuclease activity
SD85_RS19860	COG3507	Belongs to the glycosyl hydrolase 43 family
SD85_RS19865	COG0673	inositol 2-dehydrogenase activity
SD85_RS19875	COG2986	histidine ammonia-lyase
SD85_RS19880	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SD85_RS19885	COG1228	amidohydrolase
SD85_RS19890	COG0010	Belongs to the arginase family
SD85_RS19895	COG0833	amino acid
SD85_RS19900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SD85_RS19905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SD85_RS19910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SD85_RS19915	COG2390	Transcriptional regulator
SD85_RS19925	COG3192	ethanolamine utilization protein
SD85_RS19930	COG2079	MmgE PrpD family protein
SD85_RS19935	COG1473	amidohydrolase
SD85_RS19940	COG1126	abc transporter atp-binding protein
SD85_RS19945	COG0765	amino acid transport
SD85_RS19950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SD85_RS19955	COG0456	acetyltransferase
SD85_RS19960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SD85_RS19970	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SD85_RS19975	COG0561	phosphatase activity
SD85_RS20005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SD85_RS20010	COG5294	Protein conserved in bacteria
SD85_RS20015	COG0577	efflux transmembrane transporter activity
SD85_RS20020	COG1136	(ABC) transporter
SD85_RS20025	COG2205	protein histidine kinase activity
SD85_RS20030	COG0745	RESPONSE REGULATOR receiver
SD85_RS20035	COG0191	fructose-bisphosphate aldolase activity
SD85_RS20040	COG1082	Xylose isomerase domain protein TIM barrel
SD85_RS20045	COG1082	Xylose isomerase domain protein TIM barrel
SD85_RS20050	COG0673	inositol 2-dehydrogenase activity
SD85_RS20055	COG2814	Major facilitator Superfamily
SD85_RS20060	COG1082	Xylose isomerase domain protein TIM barrel
SD85_RS20065	COG3962	Belongs to the TPP enzyme family
SD85_RS20070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SD85_RS20080	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS20085	COG1349	DNA-binding transcription factor activity
SD85_RS20090	COG0667	Aldo Keto reductase
SD85_RS20105	COG2814	Major facilitator Superfamily
SD85_RS20110	COG0326	Molecular chaperone. Has ATPase activity
SD85_RS20120	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS20125	COG1309	transcriptional regulator
SD85_RS20130	COG1012	belongs to the aldehyde dehydrogenase family
SD85_RS20140	COG1714	RDD family
SD85_RS20145	COG2311	Membrane
SD85_RS20150	COG1917	Cupin 2, conserved barrel domain protein
SD85_RS20155	COG1309	transcriptional regulator
SD85_RS20160	COG1028	Short-chain dehydrogenase reductase Sdr
SD85_RS20165	COG1846	Transcriptional regulator
SD85_RS20170	COG1380	Effector of murein hydrolase LrgA
SD85_RS20175	COG1346	cytolysis
SD85_RS20185	COG5039	Polysaccharide pyruvyl transferase
SD85_RS20190	COG1929	Belongs to the glycerate kinase type-1 family
SD85_RS20195	COG1802	Transcriptional regulator
SD85_RS20200	COG1070	Carbohydrate kinase
SD85_RS20205	COG2610	gluconate transmembrane transporter activity
SD85_RS20210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SD85_RS20215	COG0450	alkyl hydroperoxide reductase
SD85_RS20220	COG3634	alkyl hydroperoxide reductase activity
SD85_RS20230	COG2723	6-phospho-beta-galactosidase activity
SD85_RS20240	COG2188	Transcriptional regulator
SD85_RS20250	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SD85_RS20255	COG0270	DNA (cytosine-5-)-methyltransferase activity
SD85_RS20280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SD85_RS20305	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
SD85_RS20310	COG0456	acetyltransferase
SD85_RS20315	COG0457	Tetratricopeptide repeat
SD85_RS20325	COG0010	Belongs to the arginase family
SD85_RS20330	COG0833	amino acid
SD85_RS20335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SD85_RS20340	COG3829	transcription factor binding
SD85_RS20350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SD85_RS20355	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SD85_RS20360	COG4853	Protein conserved in bacteria
SD85_RS20365	COG4863	YycH protein
SD85_RS20370	COG5002	protein histidine kinase activity
SD85_RS20375	COG0745	RESPONSE REGULATOR receiver
SD85_RS20405	COG0346	lactoylglutathione lyase activity
SD85_RS20410	COG0305	Participates in initiation and elongation during chromosome replication
SD85_RS20430	COG3093	addiction module antidote protein HigA
SD85_RS20435	COG2807	transmembrane transport
SD85_RS20440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SD85_RS20445	COG0359	binds to the 23S rRNA
SD85_RS20450	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SD85_RS20455	COG4241	membrane
SD85_RS20465	COG5577	PFAM Coat F domain
SD85_RS20470	COG1733	regulation of RNA biosynthetic process
SD85_RS20475	COG1227	inorganic diphosphatase activity
SD85_RS20490	COG2271	Major facilitator Superfamily
SD85_RS20505	COG2814	Major facilitator Superfamily
SD85_RS20510	COG0583	DNA-binding transcription factor activity
SD85_RS20515	COG2153	protein acetylation
SD85_RS20525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SD85_RS20530	COG1733	regulation of RNA biosynthetic process
SD85_RS20540	COG1846	Transcriptional regulator
SD85_RS20545	COG2153	protein acetylation
SD85_RS20550	COG2364	Membrane
SD85_RS20555	COG1331	Highly conserved protein containing a thioredoxin domain
SD85_RS20560	COG1266	CAAX protease self-immunity
SD85_RS20565	COG0477	Major facilitator Superfamily
SD85_RS20565	COG2814	Major facilitator Superfamily
SD85_RS20570	COG0110	maltose O-acetyltransferase activity
SD85_RS20575	COG0346	lactoylglutathione lyase activity
SD85_RS20580	COG1609	Transcriptional regulator
SD85_RS20585	COG0708	Exodeoxyribonuclease III
SD85_RS20590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SD85_RS20595	COG0629	single-stranded DNA binding
SD85_RS20600	COG0360	Binds together with S18 to 16S ribosomal RNA
SD85_RS20605	COG0012	GTP binding
SD85_RS20610	COG0243	molybdopterin cofactor binding
SD85_RS20615	COG4481	Protein conserved in bacteria
SD85_RS20620	COG3949	Membrane
SD85_RS20630	COG1475	DNA binding
SD85_RS20635	COG1192	Involved in chromosome partitioning
SD85_RS20645	COG1475	DNA binding
SD85_RS20650	COG0357	Ribosomal RNA small subunit methyltransferase G
SD85_RS20655	COG0445	tRNA wobble uridine modification
SD85_RS20660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SD85_RS20665	COG1847	R3H domain protein
SD85_RS20670	COG0706	membrane insertase activity
SD85_RS20675	COG0594	ribonuclease P activity
SD85_RS20705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria