locus-tag	class	description
IMZ18_RS00005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IMZ18_RS00010	COG1481	regulation of sporulation
IMZ18_RS00015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS00020	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IMZ18_RS00030	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS00035	COG5002	protein histidine kinase activity
IMZ18_RS00040	COG1136	(ABC) transporter
IMZ18_RS00045	COG0577	efflux transmembrane transporter activity
IMZ18_RS00050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IMZ18_RS00055	COG0288	reversible hydration of carbon dioxide
IMZ18_RS00060	COG0659	secondary active sulfate transmembrane transporter activity
IMZ18_RS00070	COG1611	Belongs to the LOG family
IMZ18_RS00075	COG1609	Transcriptional regulator
IMZ18_RS00085	COG2182	Extracellular solute-binding protein
IMZ18_RS00090	COG1175	transmembrane transport
IMZ18_RS00095	COG3833	ABC-type maltose transport systems, permease component
IMZ18_RS00100	COG5521	maltodextrose utilization protein MalA
IMZ18_RS00105	COG1554	hydrolase, family 65, central catalytic
IMZ18_RS00110	COG0366	Alpha amylase catalytic
IMZ18_RS00115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IMZ18_RS00120	COG0740	serine-type endopeptidase activity
IMZ18_RS00130	COG4974	Belongs to the 'phage' integrase family
IMZ18_RS00240	COG0582	viral genome integration into host DNA
IMZ18_RS00320	COG1705	Flagellar rod assembly protein muramidase FlgJ
IMZ18_RS00355	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS00355	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS00355	COG1388	LysM domain
IMZ18_RS00375	COG1674	ftsk spoiiie
IMZ18_RS00395	COG2076	Multidrug Resistance protein
IMZ18_RS00400	COG2076	Multidrug Resistance protein
IMZ18_RS00405	COG1309	transcriptional regulator
IMZ18_RS00410	COG0531	amino acid
IMZ18_RS00415	COG1621	beta-fructofuranosidase activity
IMZ18_RS00420	COG1621	beta-fructofuranosidase activity
IMZ18_RS00430	COG1794	racemase activity, acting on amino acids and derivatives
IMZ18_RS00445	COG3479	Phenolic acid decarboxylase
IMZ18_RS00455	COG2272	Belongs to the type-B carboxylesterase lipase family
IMZ18_RS00460	COG1396	sequence-specific DNA binding
IMZ18_RS00465	COG3944	biosynthesis protein
IMZ18_RS00470	COG0489	protein tyrosine kinase activity
IMZ18_RS00475	COG1086	Polysaccharide biosynthesis protein
IMZ18_RS00480	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS00485	COG1215	transferase activity, transferring glycosyl groups
IMZ18_RS00490	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS00500	COG1216	Glycosyl transferase, family 2
IMZ18_RS00505	COG5039	Polysaccharide pyruvyl transferase
IMZ18_RS00510	COG1216	Glycosyl transferase, family 2
IMZ18_RS00515	COG2244	polysaccharide biosynthetic process
IMZ18_RS00520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IMZ18_RS00525	COG0110	maltose O-acetyltransferase activity
IMZ18_RS00530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ18_RS00535	COG5039	Polysaccharide pyruvyl transferase
IMZ18_RS00545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IMZ18_RS00550	COG1620	l-lactate permease
IMZ18_RS00555	COG2186	Transcriptional regulator
IMZ18_RS00560	COG1609	Transcriptional regulator
IMZ18_RS00565	COG2182	Extracellular solute-binding protein
IMZ18_RS00570	COG1175	transmembrane transport
IMZ18_RS00575	COG3833	ABC-type maltose transport systems, permease component
IMZ18_RS00580	COG1874	Beta-galactosidase
IMZ18_RS00585	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IMZ18_RS00590	COG2208	phosphoserine phosphatase activity
IMZ18_RS00595	COG0596	Alpha beta hydrolase
IMZ18_RS00615	COG1131	(ABC) transporter
IMZ18_RS00620	COG0842	Transport permease protein
IMZ18_RS00625	COG4585	Histidine kinase
IMZ18_RS00630	COG2197	response regulator
IMZ18_RS00635	COG0247	lactate metabolic process
IMZ18_RS00640	COG1139	Iron-sulfur cluster binding protein
IMZ18_RS00645	COG1556	Lactate utilization protein
IMZ18_RS00655	COG1113	amino acid transport
IMZ18_RS00660	COG0697	spore germination
IMZ18_RS00665	COG0583	DNA-binding transcription factor activity
IMZ18_RS00670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IMZ18_RS00675	COG1609	Transcriptional regulator
IMZ18_RS00680	COG2814	Major facilitator Superfamily
IMZ18_RS00685	COG2390	Transcriptional regulator
IMZ18_RS00690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMZ18_RS00695	COG0126	phosphoglycerate kinase activity
IMZ18_RS00700	COG0149	triose-phosphate isomerase activity
IMZ18_RS00705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IMZ18_RS00710	COG0148	phosphopyruvate hydratase activity
IMZ18_RS00715	COG0456	acetyltransferase
IMZ18_RS00720	COG4640	response to antibiotic
IMZ18_RS00725	COG3064	Membrane
IMZ18_RS00735	COG2095	MarC family integral membrane protein
IMZ18_RS00740	COG1510	regulation of RNA biosynthetic process
IMZ18_RS00745	COG1125	glycine betaine transport
IMZ18_RS00745	COG0517	IMP dehydrogenase activity
IMZ18_RS00750	COG1174	glycine betaine transport
IMZ18_RS00755	COG1732	Glycine betaine
IMZ18_RS00760	COG1174	glycine betaine transport
IMZ18_RS00765	COG1510	regulation of RNA biosynthetic process
IMZ18_RS00770	COG0517	IMP dehydrogenase activity
IMZ18_RS00770	COG1125	glycine betaine transport
IMZ18_RS00780	COG1732	Glycine betaine
IMZ18_RS00785	COG1174	glycine betaine transport
IMZ18_RS00790	COG0840	transmembrane signaling receptor activity
IMZ18_RS00795	COG1733	regulation of RNA biosynthetic process
IMZ18_RS00800	COG1396	sequence-specific DNA binding
IMZ18_RS00805	COG1396	sequence-specific DNA binding
IMZ18_RS00810	COG1476	TRANSCRIPTIONal
IMZ18_RS00815	COG0596	Alpha beta hydrolase
IMZ18_RS00820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IMZ18_RS00825	COG1647	Serine aminopeptidase, S33
IMZ18_RS00830	COG0557	exoribonuclease II activity
IMZ18_RS00835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IMZ18_RS01075	COG3942	CHAP domain
IMZ18_RS01075	COG1705	Flagellar rod assembly protein muramidase FlgJ
IMZ18_RS01100	COG4824	toxin secretion phage lysis holin
IMZ18_RS01105	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS01105	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS01120	COG5444	nuclease activity
IMZ18_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS01135	COG1309	transcriptional regulator
IMZ18_RS01140	COG2076	Multidrug Resistance protein
IMZ18_RS01150	COG1289	transmembrane transporter activity
IMZ18_RS01160	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS01165	COG1937	Protein conserved in bacteria
IMZ18_RS01170	COG2608	mercury ion transmembrane transporter activity
IMZ18_RS01175	COG2217	Heavy metal translocating P-type atpase
IMZ18_RS01180	COG2217	Heavy metal translocating P-type atpase
IMZ18_RS01185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IMZ18_RS01190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IMZ18_RS01195	COG2860	membrane
IMZ18_RS01205	COG3973	AAA domain
IMZ18_RS01210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IMZ18_RS01215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IMZ18_RS01220	COG0025	NhaP-type Na H and K H
IMZ18_RS01230	COG0656	L-ascorbic acid biosynthetic process
IMZ18_RS01235	COG4149	molybdate abc transporter
IMZ18_RS01240	COG0725	ABC transporter, periplasmic molybdate-binding protein
IMZ18_RS01245	COG1910	domain protein
IMZ18_RS01250	COG1368	sulfuric ester hydrolase activity
IMZ18_RS01255	COG1988	membrane-bound metal-dependent
IMZ18_RS01265	COG0531	amino acid
IMZ18_RS01270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS01275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS01280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS01285	COG1120	ATPase activity
IMZ18_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IMZ18_RS01295	COG1136	(ABC) transporter
IMZ18_RS01300	COG0577	efflux transmembrane transporter activity
IMZ18_RS01310	COG2140	Oxalate decarboxylase
IMZ18_RS01330	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS01335	COG2205	protein histidine kinase activity
IMZ18_RS01340	COG3386	PFAM SMP-30 Gluconolaconase
IMZ18_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS01350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS01360	COG1120	ATPase activity
IMZ18_RS01365	COG2096	Adenosyltransferase
IMZ18_RS01370	COG2814	Major facilitator Superfamily
IMZ18_RS01375	COG4758	membrane
IMZ18_RS01380	COG1842	Phage shock protein A
IMZ18_RS01385	COG3595	metallopeptidase activity
IMZ18_RS01390	COG4758	membrane
IMZ18_RS01395	COG4585	Histidine kinase
IMZ18_RS01400	COG2197	response regulator
IMZ18_RS01410	COG0814	amino acid
IMZ18_RS01415	COG0697	spore germination
IMZ18_RS01425	COG0114	fumarate hydratase activity
IMZ18_RS01435	COG1309	transcriptional regulator
IMZ18_RS01445	COG2770	Histidine kinase
IMZ18_RS01445	COG2205	protein histidine kinase activity
IMZ18_RS01450	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS01455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ18_RS01460	COG0783	Belongs to the Dps family
IMZ18_RS01505	COG1131	(ABC) transporter
IMZ18_RS01525	COG1120	ATPase activity
IMZ18_RS01535	COG0583	DNA-binding transcription factor activity
IMZ18_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS01545	COG1942	4-Oxalocrotonate Tautomerase
IMZ18_RS01550	COG0477	Major facilitator Superfamily
IMZ18_RS01555	COG1846	Transcriptional regulator
IMZ18_RS01560	COG5577	PFAM Coat F domain
IMZ18_RS01580	COG1250	3-hydroxyacyl-CoA dehydrogenase
IMZ18_RS01580	COG1024	Enoyl-CoA hydratase
IMZ18_RS01585	COG0183	Belongs to the thiolase family
IMZ18_RS01590	COG1960	acyl-CoA dehydrogenase activity
IMZ18_RS01595	COG1393	Belongs to the ArsC family
IMZ18_RS01600	COG0509	glycine decarboxylation via glycine cleavage system
IMZ18_RS01610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IMZ18_RS01615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS01625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IMZ18_RS01630	COG2011	ABC-type metal ion transport system permease component
IMZ18_RS01635	COG1464	Belongs to the NlpA lipoprotein family
IMZ18_RS01650	COG0396	ATPase activity
IMZ18_RS01655	COG0719	Fe-S assembly protein
IMZ18_RS01660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IMZ18_RS01665	COG0822	iron-sulfur transferase activity
IMZ18_RS01670	COG0719	Fe-S assembly protein
IMZ18_RS01675	COG0640	Transcriptional regulator
IMZ18_RS01680	COG0346	lactoylglutathione lyase activity
IMZ18_RS01695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IMZ18_RS01700	COG0322	excinuclease ABC activity
IMZ18_RS01705	COG2222	sugar isomerase
IMZ18_RS01710	COG1653	transport
IMZ18_RS01715	COG1175	transmembrane transport
IMZ18_RS01725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMZ18_RS01730	COG2188	Transcriptional regulator
IMZ18_RS01735	COG3842	ATPase activity
IMZ18_RS01740	COG2356	endonuclease I
IMZ18_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMZ18_RS01755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IMZ18_RS01760	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IMZ18_RS01765	COG2068	MobA-Related Protein
IMZ18_RS01770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IMZ18_RS01775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IMZ18_RS01780	COG2080	2 iron, 2 sulfur cluster binding
IMZ18_RS01790	COG2351	hydroxyisourate hydrolase activity
IMZ18_RS01795	COG3648	Uricase
IMZ18_RS01795	COG3195	allantoin biosynthetic process
IMZ18_RS01800	COG2233	PERMEase
IMZ18_RS01805	COG2233	PERMEase
IMZ18_RS01810	COG2508	Transcriptional regulator
IMZ18_RS01825	COG1801	Protein of unknown function DUF72
IMZ18_RS01830	COG0730	response to heat
IMZ18_RS01835	COG0737	Belongs to the 5'-nucleotidase family
IMZ18_RS01840	COG3377	Domain of unknown function (DUF1805)
IMZ18_RS01850	COG0739	heme binding
IMZ18_RS01855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IMZ18_RS01865	COG4470	Protein conserved in bacteria
IMZ18_RS01870	COG2445	Protein of unknown function DUF86
IMZ18_RS01875	COG0647	UMP catabolic process
IMZ18_RS01880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IMZ18_RS01885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IMZ18_RS01890	COG0460	homoserine dehydrogenase
IMZ18_RS01895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IMZ18_RS01900	COG0083	homoserine kinase activity
IMZ18_RS01905	COG4946	Tricorn protease homolog
IMZ18_RS01905	COG1506	peptidase
IMZ18_RS01905	COG0823	Involved in the tonB-independent uptake of proteins
IMZ18_RS01910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IMZ18_RS01915	COG4837	Protein of unknown function (DUF1462)
IMZ18_RS01920	COG1252	NADH dehydrogenase
IMZ18_RS01925	COG4844	belongs to the
IMZ18_RS01930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IMZ18_RS01935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IMZ18_RS01940	COG0316	Belongs to the HesB IscA family
IMZ18_RS01945	COG4974	Belongs to the 'phage' integrase family
IMZ18_RS01955	COG0582	viral genome integration into host DNA
IMZ18_RS02065	COG0456	acetyltransferase
IMZ18_RS02070	COG2808	Putative FMN-binding domain
IMZ18_RS02075	COG0516	GMP reductase activity
IMZ18_RS02085	COG0492	ferredoxin-NADP+ reductase activity
IMZ18_RS02090	COG1252	NADH dehydrogenase
IMZ18_RS02105	COG3584	3D domain protein
IMZ18_RS02110	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IMZ18_RS02115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IMZ18_RS02120	COG2056	Na+-H+ antiporter family
IMZ18_RS02125	COG1268	BioY protein
IMZ18_RS02130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IMZ18_RS02135	COG2819	hydrolase of the alpha beta superfamily
IMZ18_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS02145	COG1169	isochorismate synthase
IMZ18_RS02150	COG1021	2,3-dihydroxybenzoate-AMP ligase
IMZ18_RS02155	COG3433	isochorismatase activity
IMZ18_RS02155	COG1535	isochorismatase
IMZ18_RS02160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IMZ18_RS02165	COG3251	PFAM MbtH domain protein
IMZ18_RS02170	COG5634	Uncharacterized conserved protein (DUF2278)
IMZ18_RS02175	COG0686	Belongs to the AlaDH PNT family
IMZ18_RS02180	COG2508	Transcriptional regulator
IMZ18_RS02180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IMZ18_RS02185	COG4842	Belongs to the WXG100 family
IMZ18_RS02190	COG5417	Belongs to the EsaB family
IMZ18_RS02195	COG4499	WXG100 protein secretion system (Wss), protein YukC
IMZ18_RS02200	COG0433	COG0433 Predicted ATPase
IMZ18_RS02200	COG1674	ftsk spoiiie
IMZ18_RS02205	COG1511	domain protein
IMZ18_RS02215	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS02220	COG1418	mRNA catabolic process
IMZ18_RS02235	COG0628	permease
IMZ18_RS02250	COG5506	Protein of unknown function (DUF1694)
IMZ18_RS02255	COG1335	isochorismatase
IMZ18_RS02260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IMZ18_RS02265	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IMZ18_RS02285	COG0142	geranyltranstransferase activity
IMZ18_RS02295	COG4585	Histidine kinase
IMZ18_RS02300	COG2197	response regulator
IMZ18_RS02305	COG2050	protein possibly involved in aromatic compounds catabolism
IMZ18_RS02310	COG1320	monovalent cation:proton antiporter activity
IMZ18_RS02315	COG2212	antiporter activity
IMZ18_RS02320	COG1863	multisubunit Na H antiporter MnhE subunit
IMZ18_RS02325	COG0651	ATP synthesis coupled electron transport
IMZ18_RS02330	COG1006	Multisubunit Na H antiporter MnhC subunit
IMZ18_RS02335	COG2111	Na H antiporter
IMZ18_RS02340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IMZ18_RS02340	COG2111	Na H antiporter
IMZ18_RS02350	COG3493	citrate carrier protein
IMZ18_RS02355	COG1079	Belongs to the binding-protein-dependent transport system permease family
IMZ18_RS02360	COG4603	Belongs to the binding-protein-dependent transport system permease family
IMZ18_RS02365	COG3845	ABC transporter
IMZ18_RS02370	COG1744	ABC transporter substrate-binding protein PnrA-like
IMZ18_RS02375	COG4565	transcriptional regulatory protein
IMZ18_RS02380	COG3290	protein histidine kinase activity
IMZ18_RS02390	COG3011	Protein conserved in bacteria
IMZ18_RS02395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IMZ18_RS02400	COG2814	Major facilitator Superfamily
IMZ18_RS02405	COG5018	Exonuclease
IMZ18_RS02415	COG2205	protein histidine kinase activity
IMZ18_RS02420	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IMZ18_RS02430	COG2267	carboxylic ester hydrolase activity
IMZ18_RS02435	COG1522	sequence-specific DNA binding
IMZ18_RS02440	COG0436	Aminotransferase
IMZ18_RS02445	COG1098	S1 RNA binding domain
IMZ18_RS02450	COG2155	Conserved Protein
IMZ18_RS02455	COG1979	alcohol dehydrogenase
IMZ18_RS02460	COG1979	alcohol dehydrogenase
IMZ18_RS02465	COG0166	Belongs to the GPI family
IMZ18_RS02480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IMZ18_RS02495	COG2738	Putative neutral zinc metallopeptidase
IMZ18_RS02500	COG1253	flavin adenine dinucleotide binding
IMZ18_RS02505	COG0366	Alpha amylase catalytic
IMZ18_RS02515	COG0432	Pfam Uncharacterised protein family UPF0047
IMZ18_RS02540	COG0840	transmembrane signaling receptor activity
IMZ18_RS02550	COG3347	Dehydrogenase
IMZ18_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS02555	COG1349	DNA-binding transcription factor activity
IMZ18_RS02560	COG1070	Carbohydrate kinase
IMZ18_RS02565	COG3254	rhamnose metabolic process
IMZ18_RS02570	COG4806	L-rhamnose isomerase
IMZ18_RS02575	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS02580	COG0628	permease
IMZ18_RS02585	COG1968	undecaprenyl-diphosphatase activity
IMZ18_RS02600	COG5553	Cysteine dioxygenase type I
IMZ18_RS02605	COG0477	Major facilitator Superfamily
IMZ18_RS02610	COG1705	Flagellar rod assembly protein muramidase FlgJ
IMZ18_RS02615	COG4682	membrane
IMZ18_RS02620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IMZ18_RS02625	COG0569	domain protein
IMZ18_RS02635	COG1510	regulation of RNA biosynthetic process
IMZ18_RS02640	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS02645	COG1454	alcohol dehydrogenase
IMZ18_RS02655	COG2318	DinB family
IMZ18_RS02660	COG1585	Membrane protein implicated in regulation of membrane protease activity
IMZ18_RS02665	COG2268	Band 7 protein
IMZ18_RS02670	COG1247	-acetyltransferase
IMZ18_RS02675	COG3859	Proton-coupled thiamine transporter YuaJ
IMZ18_RS02800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IMZ18_RS02805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IMZ18_RS02810	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IMZ18_RS02815	COG0297	glycogen (starch) synthase activity
IMZ18_RS02825	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IMZ18_RS02830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IMZ18_RS02835	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS02840	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IMZ18_RS02850	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS02855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMZ18_RS02860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IMZ18_RS02870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IMZ18_RS02875	COG1169	isochorismate synthase
IMZ18_RS02885	COG0596	Alpha beta hydrolase
IMZ18_RS02890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IMZ18_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ18_RS02900	COG4948	Mandelate Racemase Muconate Lactonizing
IMZ18_RS02905	COG0803	Belongs to the bacterial solute-binding protein 9 family
IMZ18_RS02910	COG1121	(ABC) transporter
IMZ18_RS02915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IMZ18_RS02915	COG1321	iron dependent repressor
IMZ18_RS02920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IMZ18_RS02930	COG1294	oxidase, subunit
IMZ18_RS02935	COG1271	oxidase subunit
IMZ18_RS02940	COG0254	rRNA binding
IMZ18_RS02945	COG0288	reversible hydration of carbon dioxide
IMZ18_RS02950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IMZ18_RS02955	COG1854	S-ribosylhomocysteine lyase activity
IMZ18_RS02970	COG0783	Belongs to the Dps family
IMZ18_RS02975	COG4824	toxin secretion phage lysis holin
IMZ18_RS02980	COG0494	nUDIX hydrolase
IMZ18_RS02985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IMZ18_RS02990	COG1116	anion transmembrane transporter activity
IMZ18_RS02995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IMZ18_RS03000	COG1506	peptidase
IMZ18_RS03010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IMZ18_RS03015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IMZ18_RS03020	COG0367	asparagine synthase
IMZ18_RS03025	COG1113	amino acid transport
IMZ18_RS03030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IMZ18_RS03035	COG2267	carboxylic ester hydrolase activity
IMZ18_RS03045	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IMZ18_RS03050	COG1242	4 iron, 4 sulfur cluster binding
IMZ18_RS03070	COG1725	Transcriptional regulator
IMZ18_RS03075	COG1131	(ABC) transporter
IMZ18_RS03090	COG1136	(ABC) transporter
IMZ18_RS03095	COG0577	efflux transmembrane transporter activity
IMZ18_RS03100	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS03105	COG2205	protein histidine kinase activity
IMZ18_RS03110	COG1136	(ABC) transporter
IMZ18_RS03115	COG0577	efflux transmembrane transporter activity
IMZ18_RS03120	COG2433	Pfam Transposase IS66
IMZ18_RS03125	COG2814	Major facilitator Superfamily
IMZ18_RS03130	COG2202	Pas domain
IMZ18_RS03130	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS03140	COG0495	leucyl-tRNA aminoacylation
IMZ18_RS03145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IMZ18_RS03150	COG1486	melibiose metabolic process
IMZ18_RS03155	COG0395	ABC-type sugar transport system, permease component
IMZ18_RS03160	COG1175	transmembrane transport
IMZ18_RS03165	COG1653	transport
IMZ18_RS03175	COG1073	alpha beta
IMZ18_RS03185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IMZ18_RS03205	COG2124	cytochrome p450
IMZ18_RS03210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMZ18_RS03215	COG0395	ABC-type sugar transport system, permease component
IMZ18_RS03220	COG1653	transport
IMZ18_RS03230	COG4209	transmembrane transport
IMZ18_RS03235	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IMZ18_RS03240	COG1653	transport
IMZ18_RS03260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IMZ18_RS03265	COG2081	HI0933 family
IMZ18_RS03270	COG2244	polysaccharide biosynthetic process
IMZ18_RS03275	COG1187	pseudouridine synthase activity
IMZ18_RS03280	COG1349	DNA-binding transcription factor activity
IMZ18_RS03285	COG1131	(ABC) transporter
IMZ18_RS03290	COG4473	ABC transporter
IMZ18_RS03295	COG2252	PERMEase
IMZ18_RS03300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMZ18_RS03305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IMZ18_RS03310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IMZ18_RS03320	COG1597	lipid kinase activity
IMZ18_RS03325	COG1523	belongs to the glycosyl hydrolase 13 family
IMZ18_RS03330	COG0510	thiamine kinase activity
IMZ18_RS03340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IMZ18_RS03345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS03350	COG0281	malic enzyme
IMZ18_RS03355	COG5584	Small secreted protein
IMZ18_RS03360	COG1363	Peptidase, m42
IMZ18_RS03375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS03380	COG4848	Belongs to the UPF0354 family
IMZ18_RS03385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ18_RS03390	COG1674	ftsk spoiiie
IMZ18_RS03395	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IMZ18_RS03400	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IMZ18_RS03405	COG4980	gas vesicle protein
IMZ18_RS03410	COG3118	belongs to the thioredoxin family
IMZ18_RS03415	COG1605	Chorismate mutase
IMZ18_RS03415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IMZ18_RS03420	COG1609	Transcriptional regulator
IMZ18_RS03425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IMZ18_RS03430	COG1360	Flagellar Motor Protein
IMZ18_RS03435	COG0123	including yeast histone deacetylase and acetoin utilization protein
IMZ18_RS03440	COG0517	IMP dehydrogenase activity
IMZ18_RS03445	COG0454	-acetyltransferase
IMZ18_RS03450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IMZ18_RS03455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IMZ18_RS03460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IMZ18_RS03465	COG2203	Gaf domain
IMZ18_RS03465	COG2199	diguanylate cyclase activity
IMZ18_RS03470	COG1956	GAF domain-containing protein
IMZ18_RS03475	COG1309	transcriptional regulator
IMZ18_RS03480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IMZ18_RS03485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IMZ18_RS03490	COG1114	Component of the transport system for branched-chain amino acids
IMZ18_RS03495	COG1104	cysteine desulfurase activity
IMZ18_RS03500	COG0301	tRNA thio-modification
IMZ18_RS03510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IMZ18_RS03515	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IMZ18_RS03520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IMZ18_RS03525	COG0616	signal peptide processing
IMZ18_RS03530	COG1714	RDD family
IMZ18_RS03540	COG3874	Sporulation protein YtfJ
IMZ18_RS03545	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IMZ18_RS03550	COG0827	DNA restriction-modification system
IMZ18_RS03560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IMZ18_RS03565	COG0521	Mo-molybdopterin cofactor biosynthetic process
IMZ18_RS03570	COG0137	argininosuccinate synthase activity
IMZ18_RS03575	COG0165	Argininosuccinate lyase
IMZ18_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS03585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IMZ18_RS03595	COG4109	DRTGG domain
IMZ18_RS03605	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IMZ18_RS03625	COG0587	DNA-directed DNA polymerase activity
IMZ18_RS03630	COG0281	malic enzyme
IMZ18_RS03635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IMZ18_RS03640	COG0825	malonyl-CoA metabolic process
IMZ18_RS03645	COG0205	6-phosphofructokinase activity
IMZ18_RS03650	COG0469	pyruvate kinase activity
IMZ18_RS03655	COG3030	protein affecting phage T7 exclusion by the F plasmid
IMZ18_RS03660	COG0628	permease
IMZ18_RS03665	COG2707	UPF0756 membrane protein
IMZ18_RS03670	COG0372	Belongs to the citrate synthase family
IMZ18_RS03675	COG0538	isocitrate dehydrogenase activity
IMZ18_RS03680	COG0039	L-malate dehydrogenase activity
IMZ18_RS03685	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS03690	COG5002	protein histidine kinase activity
IMZ18_RS03695	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMZ18_RS03695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMZ18_RS03700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IMZ18_RS03705	COG1971	Probably functions as a manganese efflux pump
IMZ18_RS03710	COG0237	dephospho-CoA kinase activity
IMZ18_RS03715	COG0656	L-ascorbic acid biosynthetic process
IMZ18_RS03720	COG2814	Major facilitator Superfamily
IMZ18_RS03725	COG1733	regulation of RNA biosynthetic process
IMZ18_RS03730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IMZ18_RS03735	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IMZ18_RS03740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IMZ18_RS03745	COG3611	Membrane attachment protein
IMZ18_RS03750	COG1484	DNA-dependent DNA replication
IMZ18_RS03755	COG0398	Pfam SNARE associated Golgi protein
IMZ18_RS03765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IMZ18_RS03770	COG1011	Hydrolase
IMZ18_RS03775	COG3275	phosphorelay sensor kinase activity
IMZ18_RS03780	COG3279	Response regulator of the LytR AlgR family
IMZ18_RS03785	COG1380	Effector of murein hydrolase LrgA
IMZ18_RS03790	COG1346	cytolysis
IMZ18_RS03800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IMZ18_RS03805	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IMZ18_RS03810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IMZ18_RS03815	COG3326	Membrane
IMZ18_RS03825	COG1363	Peptidase, m42
IMZ18_RS03835	COG2160	L-arabinose isomerase activity
IMZ18_RS03840	COG1069	ribulokinase activity
IMZ18_RS03845	COG0235	Class ii aldolase
IMZ18_RS03850	COG0647	UMP catabolic process
IMZ18_RS03855	COG0371	Dehydrogenase
IMZ18_RS03860	COG1653	transport
IMZ18_RS03865	COG1175	transmembrane transport
IMZ18_RS03870	COG0395	ABC-type sugar transport system, permease component
IMZ18_RS03875	COG3534	alpha-L-arabinofuranosidase
IMZ18_RS03880	COG1966	Carbon starvation protein
IMZ18_RS03885	COG0346	lactoylglutathione lyase activity
IMZ18_RS03890	COG0247	lactate metabolic process
IMZ18_RS03900	COG3835	regulator
IMZ18_RS03910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ18_RS03920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IMZ18_RS03925	COG0072	phenylalanine-tRNA ligase activity
IMZ18_RS03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ18_RS03930	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IMZ18_RS03935	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IMZ18_RS03940	COG1286	toxin biosynthetic process
IMZ18_RS03945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IMZ18_RS03945	COG1796	DNA polymerase
IMZ18_RS03950	COG1193	negative regulation of DNA recombination
IMZ18_RS03955	COG3766	membrane
IMZ18_RS03960	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ18_RS03965	COG1309	transcriptional regulator
IMZ18_RS03970	COG1024	Enoyl-CoA hydratase
IMZ18_RS03975	COG2086	electron transfer activity
IMZ18_RS03980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IMZ18_RS03985	COG3534	alpha-L-arabinofuranosidase
IMZ18_RS03990	COG3118	belongs to the thioredoxin family
IMZ18_RS03995	COG0322	excinuclease ABC activity
IMZ18_RS04000	COG0527	aspartate kinase activity
IMZ18_RS04005	COG1719	4-vinyl reductase, 4VR
IMZ18_RS04010	COG2009	succinate dehydrogenase
IMZ18_RS04015	COG1053	succinate dehydrogenase
IMZ18_RS04020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IMZ18_RS04025	COG0824	Thioesterase
IMZ18_RS04030	COG2197	response regulator
IMZ18_RS04035	COG1846	Transcriptional regulator
IMZ18_RS04040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IMZ18_RS04045	COG5401	PFAM Sporulation and spore germination
IMZ18_RS04050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IMZ18_RS04055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IMZ18_RS04060	COG0622	Phosphoesterase
IMZ18_RS04090	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IMZ18_RS04115	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
IMZ18_RS04130	COG0028	Belongs to the TPP enzyme family
IMZ18_RS04135	COG0440	acetolactate synthase activity
IMZ18_RS04140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IMZ18_RS04145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IMZ18_RS04150	COG0473	3-isopropylmalate dehydrogenase activity
IMZ18_RS04155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IMZ18_RS04160	COG0066	3-isopropylmalate dehydratase activity
IMZ18_RS04165	COG0457	Tetratricopeptide repeat
IMZ18_RS04165	COG1477	protein flavinylation
IMZ18_RS04170	COG0544	peptidyl-prolyl cis-trans isomerase activity
IMZ18_RS04175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IMZ18_RS04180	COG1067	ATP-dependent peptidase activity
IMZ18_RS04180	COG0470	DNA polymerase III
IMZ18_RS04185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IMZ18_RS04190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IMZ18_RS04200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IMZ18_RS04205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IMZ18_RS04210	COG0181	hydroxymethylbilane synthase activity
IMZ18_RS04215	COG1587	Uroporphyrinogen-III synthase
IMZ18_RS04220	COG0113	porphobilinogen synthase activity
IMZ18_RS04225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMZ18_RS04230	COG1388	LysM domain
IMZ18_RS04235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IMZ18_RS04245	COG0525	valine-tRNA ligase activity
IMZ18_RS04255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IMZ18_RS04265	COG0424	maF-like protein
IMZ18_RS04270	COG2003	Belongs to the UPF0758 family
IMZ18_RS04275	COG1077	Cell shape determining protein MreB Mrl
IMZ18_RS04285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IMZ18_RS04290	COG0850	regulation of cytokinetic process
IMZ18_RS04295	COG2894	cell division
IMZ18_RS04300	COG0739	heme binding
IMZ18_RS04305	COG1994	Peptidase M50
IMZ18_RS04310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IMZ18_RS04315	COG2868	ribosomal protein
IMZ18_RS04320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IMZ18_RS04330	COG3290	protein histidine kinase activity
IMZ18_RS04335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IMZ18_RS04340	COG4492	Belongs to the UPF0735 family
IMZ18_RS04345	COG0077	Prephenate dehydratase
IMZ18_RS04350	COG1827	regulation of RNA biosynthetic process
IMZ18_RS04355	COG1104	cysteine desulfurase activity
IMZ18_RS04360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IMZ18_RS04365	COG0157	Belongs to the NadC ModD family
IMZ18_RS04370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IMZ18_RS04375	COG1388	LysM domain
IMZ18_RS04385	COG0217	transcriptional regulatory protein
IMZ18_RS04390	COG1115	amino acid carrier protein
IMZ18_RS04410	COG2112	serine threonine protein kinase
IMZ18_RS04415	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS04420	COG2814	Major facilitator Superfamily
IMZ18_RS04430	COG0632	four-way junction helicase activity
IMZ18_RS04435	COG2255	four-way junction helicase activity
IMZ18_RS04445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IMZ18_RS04450	COG0343	queuine tRNA-ribosyltransferase activity
IMZ18_RS04465	COG2323	membrane
IMZ18_RS04470	COG2244	polysaccharide biosynthetic process
IMZ18_RS04480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMZ18_RS04480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IMZ18_RS04485	COG0490	domain, Protein
IMZ18_RS04490	COG5416	Lipopolysaccharide assembly protein A domain
IMZ18_RS04495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IMZ18_RS04495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IMZ18_RS04500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IMZ18_RS04505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IMZ18_RS04510	COG1490	D-aminoacyl-tRNA deacylase activity
IMZ18_RS04515	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS04515	COG4991	sh3 domain protein
IMZ18_RS04515	COG3103	Sh3 type 3 domain protein
IMZ18_RS04525	COG0124	histidyl-tRNA synthetase
IMZ18_RS04530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IMZ18_RS04540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IMZ18_RS04550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IMZ18_RS04555	COG1959	2 iron, 2 sulfur cluster binding
IMZ18_RS04560	COG1104	cysteine desulfurase activity
IMZ18_RS04565	COG0482	sulfurtransferase activity
IMZ18_RS04570	COG0457	Tetratricopeptide repeat
IMZ18_RS04575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IMZ18_RS04580	COG3881	PFAM PRC-barrel domain
IMZ18_RS04595	COG0765	amino acid transport
IMZ18_RS04600	COG0765	amino acid transport
IMZ18_RS04605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMZ18_RS04610	COG1126	abc transporter atp-binding protein
IMZ18_RS04615	COG0628	permease
IMZ18_RS04620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IMZ18_RS04625	COG4472	Bacterial protein of unknown function (DUF965)
IMZ18_RS04630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IMZ18_RS04635	COG3906	Belongs to the UPF0473 family
IMZ18_RS04640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IMZ18_RS04645	COG4122	O-methyltransferase activity
IMZ18_RS04650	COG0826	peptidase U32
IMZ18_RS04655	COG0826	peptidase U32
IMZ18_RS04660	COG0572	uridine kinase
IMZ18_RS04665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IMZ18_RS04670	COG0768	penicillin binding
IMZ18_RS04685	COG2226	methyltransferase
IMZ18_RS04690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IMZ18_RS04695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IMZ18_RS04700	COG0626	cystathionine gamma-synthase activity
IMZ18_RS04715	COG2427	Protein of unknown function (DUF1641)
IMZ18_RS04720	COG3383	formate dehydrogenase (NAD+) activity
IMZ18_RS04725	COG5609	conserved protein (DUF2294)
IMZ18_RS04730	COG2116	formate transmembrane transporter activity
IMZ18_RS04745	COG2226	methyltransferase
IMZ18_RS04750	COG1309	transcriptional regulator
IMZ18_RS04775	COG1595	DNA-templated transcription, initiation
IMZ18_RS04780	COG1378	Sugar-specific transcriptional regulator TrmB
IMZ18_RS04785	COG1280	lysine exporter protein (LysE YggA)
IMZ18_RS04790	COG1113	amino acid transport
IMZ18_RS04800	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IMZ18_RS04800	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IMZ18_RS04805	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS04810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS04815	COG3715	PTS system
IMZ18_RS04820	COG3716	PTS system mannose fructose sorbose family IID component
IMZ18_RS04825	COG1621	beta-fructofuranosidase activity
IMZ18_RS04830	COG0693	protein deglycase activity
IMZ18_RS04835	COG1064	alcohol dehydrogenase
IMZ18_RS04845	COG0789	Transcriptional regulator
IMZ18_RS04850	COG5577	PFAM Coat F domain
IMZ18_RS04860	COG1063	alcohol dehydrogenase
IMZ18_RS04865	COG5577	PFAM Coat F domain
IMZ18_RS04875	COG0346	lactoylglutathione lyase activity
IMZ18_RS04885	COG4991	sh3 domain protein
IMZ18_RS04890	COG4991	sh3 domain protein
IMZ18_RS04900	COG5566	PFAM Mor transcription activator
IMZ18_RS04905	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS04910	COG0667	Aldo Keto reductase
IMZ18_RS04915	COG1595	DNA-templated transcription, initiation
IMZ18_RS04920	COG3443	Belongs to the bacterial solute-binding protein 9 family
IMZ18_RS04940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IMZ18_RS04945	COG2070	2-Nitropropane dioxygenase
IMZ18_RS04955	COG2318	DinB family
IMZ18_RS04975	COG1335	isochorismatase
IMZ18_RS04990	COG2124	cytochrome p450
IMZ18_RS04995	COG2732	(Barnase) inhibitor
IMZ18_RS05000	COG1522	sequence-specific DNA binding
IMZ18_RS05015	COG1114	Component of the transport system for branched-chain amino acids
IMZ18_RS05025	COG1230	cation diffusion facilitator family transporter
IMZ18_RS05030	COG2072	flavoprotein involved in K transport
IMZ18_RS05035	COG0583	DNA-binding transcription factor activity
IMZ18_RS05040	COG0697	spore germination
IMZ18_RS05050	COG1253	flavin adenine dinucleotide binding
IMZ18_RS05055	COG0456	acetyltransferase
IMZ18_RS05060	COG2814	Major facilitator Superfamily
IMZ18_RS05065	COG0789	Transcriptional regulator
IMZ18_RS05065	COG4978	Transcriptional regulator
IMZ18_RS05190	COG0457	Tetratricopeptide repeat
IMZ18_RS05200	COG0583	DNA-binding transcription factor activity
IMZ18_RS05205	COG0114	fumarate hydratase activity
IMZ18_RS05225	COG3209	COG3209 Rhs family protein
IMZ18_RS05235	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IMZ18_RS05240	COG0398	Pfam SNARE associated Golgi protein
IMZ18_RS05245	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS05245	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS05250	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS05260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IMZ18_RS05265	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IMZ18_RS05270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IMZ18_RS05275	COG1534	Rna-binding protein
IMZ18_RS05280	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IMZ18_RS05285	COG1713	HD superfamily hydrolase involved in NAD metabolism
IMZ18_RS05290	COG0799	negative regulation of ribosome biogenesis
IMZ18_RS05295	COG2226	methyltransferase
IMZ18_RS05300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IMZ18_RS05305	COG1555	photosystem II stabilization
IMZ18_RS05305	COG1596	polysaccharide export
IMZ18_RS05310	COG2131	deaminase
IMZ18_RS05315	COG2333	competence protein COMEC
IMZ18_RS05315	COG0658	competence protein
IMZ18_RS05330	COG1466	dna polymerase III delta subunit
IMZ18_RS05335	COG0268	Binds directly to 16S ribosomal RNA
IMZ18_RS05340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IMZ18_RS05345	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS05355	COG0481	GTPase activity
IMZ18_RS05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IMZ18_RS05365	COG1420	regulation of RNA biosynthetic process
IMZ18_RS05370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IMZ18_RS05380	COG0484	heat shock protein binding
IMZ18_RS05385	COG2264	protein methyltransferase activity
IMZ18_RS05390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IMZ18_RS05395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMZ18_RS05400	COG1283	sodium-dependent phosphate transmembrane transporter activity
IMZ18_RS05410	COG1610	YqeY-like protein
IMZ18_RS05415	COG1030	water channel activity
IMZ18_RS05420	COG4864	UPF0365 protein
IMZ18_RS05435	COG0561	phosphatase activity
IMZ18_RS05440	COG1702	phosphate starvation-inducible protein PhoH
IMZ18_RS05445	COG1480	7TM receptor with intracellular HD hydrolase
IMZ18_RS05450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IMZ18_RS05455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IMZ18_RS05460	COG0295	cytidine deaminase activity
IMZ18_RS05465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IMZ18_RS05475	COG1381	Involved in DNA repair and RecF pathway recombination
IMZ18_RS05480	COG0752	glycyl-tRNA synthetase alpha subunit
IMZ18_RS05485	COG0751	glycine-tRNA ligase activity
IMZ18_RS05490	COG0517	IMP dehydrogenase activity
IMZ18_RS05495	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IMZ18_RS05500	COG1671	Belongs to the UPF0178 family
IMZ18_RS05505	COG0358	DNA primase activity
IMZ18_RS05510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IMZ18_RS05515	COG2010	Cytochrome c
IMZ18_RS05520	COG2384	SAM-dependent methyltransferase
IMZ18_RS05525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IMZ18_RS05530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IMZ18_RS05540	COG0513	Belongs to the DEAD box helicase family
IMZ18_RS05545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IMZ18_RS05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS05560	COG0735	belongs to the Fur family
IMZ18_RS05565	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IMZ18_RS05570	COG4709	membrane
IMZ18_RS05575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IMZ18_RS05580	COG1388	LysM domain
IMZ18_RS05585	COG5521	maltodextrose utilization protein MalA
IMZ18_RS05590	COG2839	Protein conserved in bacteria
IMZ18_RS05595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IMZ18_RS05600	COG0477	Major facilitator Superfamily
IMZ18_RS05605	COG0768	penicillin binding
IMZ18_RS05610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IMZ18_RS05615	COG0573	inorganic phosphate transmembrane transporter activity
IMZ18_RS05620	COG0581	inorganic phosphate transmembrane transporter activity
IMZ18_RS05625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IMZ18_RS05630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IMZ18_RS05635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IMZ18_RS05650	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS05660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IMZ18_RS05670	COG0457	Tetratricopeptide repeat
IMZ18_RS05670	COG0705	Rhomboid family
IMZ18_RS05675	COG4483	Protein conserved in bacteria
IMZ18_RS05680	COG1940	carbohydrate kinase activity
IMZ18_RS05685	COG1368	sulfuric ester hydrolase activity
IMZ18_RS05690	COG2866	Carboxypeptidase
IMZ18_RS05700	COG0011	TIGRFAM Protein of
IMZ18_RS05710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS05720	COG1393	Belongs to the ArsC family
IMZ18_RS05730	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS05735	COG1253	flavin adenine dinucleotide binding
IMZ18_RS05740	COG0598	Magnesium transport protein CorA
IMZ18_RS05745	COG0517	IMP dehydrogenase activity
IMZ18_RS05750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IMZ18_RS05755	COG1459	type II secretion system
IMZ18_RS05760	COG4537	Required for transformation and DNA binding
IMZ18_RS05765	COG4970	Tfp pilus assembly protein FimT
IMZ18_RS05775	COG4940	Competence protein ComGF
IMZ18_RS05800	COG0681	Belongs to the peptidase S26 family
IMZ18_RS05810	COG1396	sequence-specific DNA binding
IMZ18_RS05825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IMZ18_RS05830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IMZ18_RS05835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IMZ18_RS05840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IMZ18_RS05845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IMZ18_RS05850	COG0095	Lipoate-protein ligase
IMZ18_RS05855	COG1321	iron dependent repressor
IMZ18_RS05860	COG1752	Esterase of the alpha-beta hydrolase superfamily
IMZ18_RS05870	COG3872	metal-dependent enzyme
IMZ18_RS05880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IMZ18_RS05885	COG0006	proline dipeptidase activity
IMZ18_RS05890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IMZ18_RS05900	COG3854	ATPases associated with a variety of cellular activities
IMZ18_RS05945	COG0511	ligase activity, forming carbon-carbon bonds
IMZ18_RS05950	COG0439	Biotin carboxylase
IMZ18_RS05955	COG1302	Protein conserved in bacteria
IMZ18_RS05960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IMZ18_RS05965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IMZ18_RS05970	COG1570	exodeoxyribonuclease VII activity
IMZ18_RS05975	COG1722	exodeoxyribonuclease VII activity
IMZ18_RS05980	COG0142	geranyltranstransferase activity
IMZ18_RS05985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IMZ18_RS05990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IMZ18_RS05995	COG1438	arginine binding
IMZ18_RS06000	COG0497	DNA recombination
IMZ18_RS06005	COG0750	zinc metalloprotease
IMZ18_RS06010	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS06015	COG1902	pentaerythritol trinitrate reductase activity
IMZ18_RS06030	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS06035	COG0584	glycerophosphoryl diester phosphodiesterase
IMZ18_RS06045	COG1250	3-hydroxyacyl-CoA dehydrogenase
IMZ18_RS06050	COG1960	acyl-CoA dehydrogenase activity
IMZ18_RS06055	COG0372	Belongs to the citrate synthase family
IMZ18_RS06060	COG2079	MmgE PrpD family protein
IMZ18_RS06065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IMZ18_RS06075	COG3290	protein histidine kinase activity
IMZ18_RS06075	COG3829	transcription factor binding
IMZ18_RS06080	COG0280	phosphate acetyltransferase
IMZ18_RS06085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IMZ18_RS06090	COG3426	butyrate kinase activity
IMZ18_RS06095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IMZ18_RS06100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IMZ18_RS06105	COG0022	dehydrogenase e1 component
IMZ18_RS06110	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMZ18_RS06115	COG0789	Transcriptional regulator
IMZ18_RS06115	COG4978	Transcriptional regulator
IMZ18_RS06125	COG1597	lipid kinase activity
IMZ18_RS06135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMZ18_RS06140	COG0765	amino acid transport
IMZ18_RS06145	COG1126	abc transporter atp-binding protein
IMZ18_RS06150	COG4129	membrane
IMZ18_RS06155	COG1376	ErfK ybiS ycfS ynhG family protein
IMZ18_RS06165	COG0346	lactoylglutathione lyase activity
IMZ18_RS06175	COG2195	Cleaves the N-terminal amino acid of tripeptides
IMZ18_RS06180	COG3361	conserved protein (COG2071)
IMZ18_RS06185	COG0706	membrane insertase activity
IMZ18_RS06195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IMZ18_RS06200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IMZ18_RS06205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IMZ18_RS06210	COG1234	tRNA 3'-trailer cleavage
IMZ18_RS06220	COG0596	Alpha beta hydrolase
IMZ18_RS06230	COG1902	pentaerythritol trinitrate reductase activity
IMZ18_RS06240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IMZ18_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS06250	COG0300	oxidoreductase activity
IMZ18_RS06255	COG3048	D-serine ammonia-lyase activity
IMZ18_RS06260	COG1072	(Pantothenic acid kinase))
IMZ18_RS06265	COG0346	lactoylglutathione lyase activity
IMZ18_RS06275	COG2211	Major facilitator Superfamily
IMZ18_RS06285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IMZ18_RS06295	COG0456	acetyltransferase
IMZ18_RS06300	COG2329	Antibiotic biosynthesis monooxygenase
IMZ18_RS06305	COG0456	acetyltransferase
IMZ18_RS06305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IMZ18_RS06310	COG4918	Iron-sulphur cluster biosynthesis
IMZ18_RS06320	COG1073	alpha beta
IMZ18_RS06330	COG0667	Aldo Keto reductase
IMZ18_RS06340	COG0494	nUDIX hydrolase
IMZ18_RS06345	COG1379	DNA repair
IMZ18_RS06350	COG1396	sequence-specific DNA binding
IMZ18_RS06355	COG0252	asparaginase activity
IMZ18_RS06360	COG1027	Aspartate ammonia-lyase
IMZ18_RS06365	COG1757	Na H antiporter
IMZ18_RS06370	COG0281	malic enzyme
IMZ18_RS06380	COG1300	Membrane
IMZ18_RS06385	COG0735	belongs to the Fur family
IMZ18_RS06395	COG4974	Belongs to the 'phage' integrase family
IMZ18_RS06400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IMZ18_RS06405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IMZ18_RS06410	COG1686	Belongs to the peptidase S11 family
IMZ18_RS06415	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS06420	COG2172	sigma factor antagonist activity
IMZ18_RS06425	COG1191	sigma factor activity
IMZ18_RS06445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IMZ18_RS06460	COG0697	spore germination
IMZ18_RS06465	COG0019	diaminopimelate decarboxylase activity
IMZ18_RS06470	COG4086	secreted protein
IMZ18_RS06480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IMZ18_RS06530	COG3328	transposase activity
IMZ18_RS06585	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IMZ18_RS06595	COG0681	Belongs to the peptidase S26 family
IMZ18_RS06605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IMZ18_RS06605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IMZ18_RS06610	COG0307	riboflavin synthase, alpha
IMZ18_RS06615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMZ18_RS06615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IMZ18_RS06620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IMZ18_RS06625	COG0456	acetyltransferase
IMZ18_RS06630	COG1547	Domain of unknown function (DUF309)
IMZ18_RS06635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IMZ18_RS06640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IMZ18_RS06655	COG1686	Belongs to the peptidase S11 family
IMZ18_RS06660	COG2715	membrane protein required for spore maturation
IMZ18_RS06665	COG0700	Nucleoside recognition
IMZ18_RS06670	COG1187	pseudouridine synthase activity
IMZ18_RS06675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS06680	COG1333	cytochrome c biogenesis protein
IMZ18_RS06685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IMZ18_RS06690	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS06695	COG5002	protein histidine kinase activity
IMZ18_RS06700	COG1595	DNA-templated transcription, initiation
IMZ18_RS06710	COG0710	3-dehydroquinate dehydratase activity
IMZ18_RS06715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IMZ18_RS06720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IMZ18_RS06730	COG1141	Ferredoxin
IMZ18_RS06735	COG4955	Helix-turn-helix domain
IMZ18_RS06745	COG1266	CAAX protease self-immunity
IMZ18_RS06750	COG1388	LysM domain
IMZ18_RS06760	COG1408	metallophosphoesterase
IMZ18_RS06765	COG4862	establishment of competence for transformation
IMZ18_RS06770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IMZ18_RS06775	COG0492	ferredoxin-NADP+ reductase activity
IMZ18_RS06780	COG2339	peptidase activity
IMZ18_RS06785	COG3773	Cell wall hydrolase
IMZ18_RS06785	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS06790	COG2959	enzyme of heme biosynthesis
IMZ18_RS06795	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IMZ18_RS06805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IMZ18_RS06810	COG0539	negative regulation of cytoplasmic translation
IMZ18_RS06815	COG1304	FMN binding
IMZ18_RS06840	COG1160	GTP binding
IMZ18_RS06845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IMZ18_RS06860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IMZ18_RS06865	COG0776	regulation of translation
IMZ18_RS06870	COG0302	gtp cyclohydrolase
IMZ18_RS06880	COG0142	geranyltranstransferase activity
IMZ18_RS06885	COG2226	methyltransferase
IMZ18_RS06890	COG0142	geranyltranstransferase activity
IMZ18_RS06895	COG0105	UTP biosynthetic process
IMZ18_RS06900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IMZ18_RS06905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IMZ18_RS06910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IMZ18_RS06915	COG4401	Chorismate mutase type I
IMZ18_RS06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMZ18_RS06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IMZ18_RS06935	COG0135	phosphoribosylanthranilate isomerase activity
IMZ18_RS06940	COG0133	tryptophan synthase activity
IMZ18_RS06955	COG0287	Prephenate dehydrogenase
IMZ18_RS06960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IMZ18_RS06965	COG0457	Tetratricopeptide repeat
IMZ18_RS06970	COG5582	Belongs to the UPF0302 family
IMZ18_RS06980	COG0723	plastoquinol--plastocyanin reductase activity
IMZ18_RS06985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IMZ18_RS06990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IMZ18_RS06990	COG2010	Cytochrome c
IMZ18_RS06995	COG4347	Protein of unknown function (DUF1405)
IMZ18_RS07005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS07010	COG1694	Mazg nucleotide pyrophosphohydrolase
IMZ18_RS07015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IMZ18_RS07020	COG1803	Methylglyoxal synthase
IMZ18_RS07025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IMZ18_RS07030	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS07035	COG0617	tRNA 3'-terminal CCA addition
IMZ18_RS07040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IMZ18_RS07040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IMZ18_RS07045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IMZ18_RS07050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IMZ18_RS07055	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IMZ18_RS07060	COG1199	ATP-dependent helicase activity
IMZ18_RS07060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IMZ18_RS07070	COG5353	protein conserved in bacteria
IMZ18_RS07075	COG0436	Aminotransferase
IMZ18_RS07080	COG0017	Asparaginyl-tRNA synthetase
IMZ18_RS07085	COG3935	DnaD domain protein
IMZ18_RS07090	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IMZ18_RS07100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IMZ18_RS07100	COG4499	WXG100 protein secretion system (Wss), protein YukC
IMZ18_RS07105	COG3331	DNA recombination
IMZ18_RS07140	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ18_RS07145	COG2190	(PTS) system
IMZ18_RS07150	COG1205	dead DEAH box helicase
IMZ18_RS07150	COG1111	helicase
IMZ18_RS07155	COG3359	exonuclease
IMZ18_RS07170	COG4474	Belongs to the UPF0398 family
IMZ18_RS07185	COG0116	Belongs to the methyltransferase superfamily
IMZ18_RS07200	COG1199	ATP-dependent helicase activity
IMZ18_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS07210	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IMZ18_RS07215	COG1609	Transcriptional regulator
IMZ18_RS07220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMZ18_RS07235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IMZ18_RS07240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IMZ18_RS07245	COG2233	PERMEase
IMZ18_RS07250	COG3424	synthase
IMZ18_RS07255	COG1755	Isoprenylcysteine carboxyl methyltransferase
IMZ18_RS07265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IMZ18_RS07280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IMZ18_RS07290	COG0328	RNA-DNA hybrid ribonuclease activity
IMZ18_RS07295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IMZ18_RS07300	COG0328	RNA-DNA hybrid ribonuclease activity
IMZ18_RS07320	COG1278	Cold shock
IMZ18_RS07330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMZ18_RS07335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IMZ18_RS07340	COG0386	Belongs to the glutathione peroxidase family
IMZ18_RS07345	COG1418	mRNA catabolic process
IMZ18_RS07350	COG1413	lyase activity
IMZ18_RS07355	COG0129	dihydroxy-acid dehydratase activity
IMZ18_RS07365	COG2136	Putative SAM-dependent methyltransferase
IMZ18_RS07365	COG2521	methyltransferase
IMZ18_RS07375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IMZ18_RS07380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IMZ18_RS07385	COG0204	Acyl-transferase
IMZ18_RS07390	COG1272	protein, Hemolysin III
IMZ18_RS07395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IMZ18_RS07400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IMZ18_RS07410	COG1999	signal sequence binding
IMZ18_RS07415	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS07420	COG4698	Protein conserved in bacteria
IMZ18_RS07430	COG0534	Mate efflux family protein
IMZ18_RS07435	COG1846	Transcriptional regulator
IMZ18_RS07440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ18_RS07445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IMZ18_RS07450	COG1086	Polysaccharide biosynthesis protein
IMZ18_RS07455	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
IMZ18_RS07460	COG4641	Protein conserved in bacteria
IMZ18_RS07475	COG0463	Glycosyl transferase, family 2
IMZ18_RS07480	COG0456	acetyltransferase
IMZ18_RS07500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IMZ18_RS07505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IMZ18_RS07510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IMZ18_RS07515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMZ18_RS07520	COG0456	acetyltransferase
IMZ18_RS07525	COG1509	lysine 2,3-aminomutase activity
IMZ18_RS07535	COG4479	Belongs to the UPF0346 family
IMZ18_RS07555	COG0671	phosphoesterase, PA-phosphatase related
IMZ18_RS07570	COG0813	purine-nucleoside phosphorylase activity
IMZ18_RS07575	COG1876	peptidase activity
IMZ18_RS07585	COG2226	methyltransferase
IMZ18_RS07590	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS07590	COG0793	Belongs to the peptidase S41A family
IMZ18_RS07595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ18_RS07610	COG0400	carboxylic ester hydrolase activity
IMZ18_RS07620	COG0778	Nitroreductase
IMZ18_RS07625	COG1733	regulation of RNA biosynthetic process
IMZ18_RS07630	COG1942	4-Oxalocrotonate Tautomerase
IMZ18_RS07650	COG2962	Rard protein
IMZ18_RS07660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IMZ18_RS07665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IMZ18_RS07670	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS07675	COG0534	Mate efflux family protein
IMZ18_RS07680	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IMZ18_RS07685	COG1819	glycosyl
IMZ18_RS07690	COG1388	LysM domain
IMZ18_RS07690	COG0791	NLP P60 protein
IMZ18_RS07695	COG2032	superoxide dismutase activity
IMZ18_RS07700	COG0714	Associated with various cellular activities
IMZ18_RS07705	COG4548	von Willebrand factor, type A
IMZ18_RS07710	COG0567	Dehydrogenase, E1 component
IMZ18_RS07715	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMZ18_RS07720	COG0385	Bile acid
IMZ18_RS07725	COG0733	neurotransmitter:sodium symporter activity
IMZ18_RS07730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IMZ18_RS07735	COG1657	PFAM Prenyltransferase squalene oxidase
IMZ18_RS07740	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS07765	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ18_RS07780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IMZ18_RS07785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IMZ18_RS07795	COG0514	ATP-dependent DNA helicase (RecQ)
IMZ18_RS07800	COG1388	LysM domain
IMZ18_RS07800	COG3584	3D domain protein
IMZ18_RS07805	COG2197	response regulator
IMZ18_RS07810	COG4585	Histidine kinase
IMZ18_RS07815	COG3239	Fatty acid desaturase
IMZ18_RS07820	COG1619	proteins homologs of microcin C7 resistance protein MccF
IMZ18_RS07835	COG2322	membrane
IMZ18_RS07840	COG0741	lytic transglycosylase activity
IMZ18_RS07845	COG0640	Transcriptional regulator
IMZ18_RS07855	COG2378	regulation of single-species biofilm formation
IMZ18_RS07860	COG3708	Transcriptional regulator
IMZ18_RS07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS07870	COG1309	transcriptional regulator
IMZ18_RS07875	COG0456	acetyltransferase
IMZ18_RS07880	COG2207	Transcriptional regulator
IMZ18_RS07880	COG0662	Cupin 2, conserved barrel domain protein
IMZ18_RS07885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ18_RS07890	COG1231	oxidoreductase activity
IMZ18_RS07895	COG4282	regulation of fungal-type cell wall biogenesis
IMZ18_RS07900	COG5444	nuclease activity
IMZ18_RS07920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS07950	COG3328	transposase activity
IMZ18_RS07955	COG2211	Major facilitator Superfamily
IMZ18_RS07960	COG2226	methyltransferase
IMZ18_RS07965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IMZ18_RS08020	COG3328	transposase activity
IMZ18_RS08050	COG3328	transposase activity
IMZ18_RS08055	COG2814	Major facilitator Superfamily
IMZ18_RS08065	COG1131	(ABC) transporter
IMZ18_RS08080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS08090	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IMZ18_RS08095	COG0300	oxidoreductase activity
IMZ18_RS08125	COG0583	DNA-binding transcription factor activity
IMZ18_RS08130	COG0067	glutamate synthase
IMZ18_RS08130	COG0069	glutamate synthase activity
IMZ18_RS08130	COG0070	glutamate synthase
IMZ18_RS08135	COG0493	'glutamate synthase
IMZ18_RS08140	COG0604	alcohol dehydrogenase
IMZ18_RS08145	COG0583	DNA-binding transcription factor activity
IMZ18_RS08150	COG0405	Gamma-glutamyltransferase
IMZ18_RS08155	COG0166	Belongs to the GPI family
IMZ18_RS08160	COG0582	viral genome integration into host DNA
IMZ18_RS08180	COG0534	Mate efflux family protein
IMZ18_RS08185	COG2017	converts alpha-aldose to the beta-anomer
IMZ18_RS08190	COG2027	D-alanyl-D-alanine carboxypeptidase
IMZ18_RS08210	COG1649	PFAM Uncharacterised BCR, COG1649
IMZ18_RS08220	COG1960	acyl-CoA dehydrogenase activity
IMZ18_RS08230	COG0439	Biotin carboxylase
IMZ18_RS08235	COG0511	ligase activity, forming carbon-carbon bonds
IMZ18_RS08240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IMZ18_RS08245	COG1024	Enoyl-CoA hydratase
IMZ18_RS08250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IMZ18_RS08255	COG2404	hydrolase activity, acting on ester bonds
IMZ18_RS08265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IMZ18_RS08270	COG2246	polysaccharide biosynthetic process
IMZ18_RS08290	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IMZ18_RS08295	COG1115	amino acid carrier protein
IMZ18_RS08305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IMZ18_RS08315	COG1832	CoA-binding protein
IMZ18_RS08320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IMZ18_RS08325	COG4841	protein insertion into membrane
IMZ18_RS08340	COG0824	Thioesterase
IMZ18_RS08360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS08365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IMZ18_RS08380	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ18_RS08390	COG4846	Membrane protein involved in cytochrome C biogenesis
IMZ18_RS08395	COG2201	protein-glutamate methylesterase activity
IMZ18_RS08400	COG0785	Cytochrome C biogenesis protein
IMZ18_RS08410	COG3763	UPF0154 protein
IMZ18_RS08420	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IMZ18_RS08425	COG4224	UPF0291 protein
IMZ18_RS08430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IMZ18_RS08435	COG1388	LysM domain
IMZ18_RS08440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IMZ18_RS08445	COG0346	lactoylglutathione lyase activity
IMZ18_RS08455	COG4195	phage-related replication protein
IMZ18_RS08500	COG3832	glyoxalase III activity
IMZ18_RS08515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMZ18_RS08560	COG0756	dUTP diphosphatase activity
IMZ18_RS08575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IMZ18_RS08580	COG2814	Major facilitator Superfamily
IMZ18_RS08585	COG1525	nuclease
IMZ18_RS08590	COG3328	transposase activity
IMZ18_RS08600	COG1070	Carbohydrate kinase
IMZ18_RS08605	COG2115	Belongs to the xylose isomerase family
IMZ18_RS08610	COG1940	carbohydrate kinase activity
IMZ18_RS08615	COG3507	Belongs to the glycosyl hydrolase 43 family
IMZ18_RS08630	COG2211	Major facilitator Superfamily
IMZ18_RS08635	COG0135	phosphoribosylanthranilate isomerase activity
IMZ18_RS08660	COG3655	Transcriptional regulator
IMZ18_RS08675	COG3328	transposase activity
IMZ18_RS08695	COG4282	regulation of fungal-type cell wall biogenesis
IMZ18_RS08730	COG5444	nuclease activity
IMZ18_RS08740	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS08740	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS08740	COG1388	LysM domain
IMZ18_RS08785	COG3953	SLT domain
IMZ18_RS08785	COG5412	phage tail tape measure protein
IMZ18_RS08930	COG3645	SOS response
IMZ18_RS08930	COG3646	Phage regulatory protein
IMZ18_RS08950	COG4974	Belongs to the 'phage' integrase family
IMZ18_RS08955	COG0174	glutamine synthetase
IMZ18_RS08960	COG0789	Transcriptional regulator
IMZ18_RS08965	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IMZ18_RS08970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IMZ18_RS08975	COG0464	growth
IMZ18_RS08980	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS08985	COG4112	unkown
IMZ18_RS08990	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IMZ18_RS08995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IMZ18_RS09000	COG1780	Probably involved in ribonucleotide reductase function
IMZ18_RS09015	COG1923	regulation of RNA biosynthetic process
IMZ18_RS09020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IMZ18_RS09035	COG2076	Multidrug Resistance protein
IMZ18_RS09040	COG2076	Multidrug Resistance protein
IMZ18_RS09045	COG1764	response to oxidative stress
IMZ18_RS09050	COG4195	phage-related replication protein
IMZ18_RS09060	COG1404	Belongs to the peptidase S8 family
IMZ18_RS09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS09075	COG3226	Transcriptional regulator
IMZ18_RS09090	COG3328	transposase activity
IMZ18_RS09180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IMZ18_RS09185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IMZ18_RS09195	COG4550	Control of competence regulator ComK, YlbF/YmcA
IMZ18_RS09200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IMZ18_RS09205	COG0156	8-amino-7-oxononanoate synthase activity
IMZ18_RS09210	COG1063	alcohol dehydrogenase
IMZ18_RS09215	COG2359	stage V sporulation protein S
IMZ18_RS09220	COG1692	metallophosphoesterase
IMZ18_RS09225	COG1418	mRNA catabolic process
IMZ18_RS09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IMZ18_RS09235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IMZ18_RS09245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IMZ18_RS09250	COG1426	Protein conserved in bacteria
IMZ18_RS09265	COG0300	oxidoreductase activity
IMZ18_RS09270	COG0612	Peptidase, M16
IMZ18_RS09275	COG0612	Peptidase, M16
IMZ18_RS09280	COG2814	Major facilitator Superfamily
IMZ18_RS09285	COG2188	Transcriptional regulator
IMZ18_RS09290	COG4980	gas vesicle protein
IMZ18_RS09290	COG1674	ftsk spoiiie
IMZ18_RS09300	COG0740	serine-type endopeptidase activity
IMZ18_RS09305	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IMZ18_RS09310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IMZ18_RS09315	COG0527	aspartate kinase activity
IMZ18_RS09320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IMZ18_RS09325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IMZ18_RS09330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IMZ18_RS09335	COG1873	PFAM PRC-barrel domain
IMZ18_RS09340	COG0612	Peptidase, M16
IMZ18_RS09345	COG0726	polysaccharide deacetylase
IMZ18_RS09350	COG1185	polyribonucleotide nucleotidyltransferase activity
IMZ18_RS09355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IMZ18_RS09360	COG0196	riboflavin kinase activity
IMZ18_RS09365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IMZ18_RS09370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IMZ18_RS09375	COG1550	Protein conserved in bacteria
IMZ18_RS09380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IMZ18_RS09385	COG1358	cellular component organization or biogenesis
IMZ18_RS09390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IMZ18_RS09395	COG0195	Participates in both transcription termination and antitermination
IMZ18_RS09400	COG0779	Required for maturation of 30S ribosomal subunits
IMZ18_RS09410	COG0442	prolyl-tRNA aminoacylation
IMZ18_RS09415	COG0750	zinc metalloprotease
IMZ18_RS09420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IMZ18_RS09425	COG4589	Belongs to the CDS family
IMZ18_RS09430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IMZ18_RS09435	COG0233	cytoplasmic translational termination
IMZ18_RS09440	COG0528	UMP kinase activity
IMZ18_RS09445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IMZ18_RS09450	COG0052	Belongs to the universal ribosomal protein uS2 family
IMZ18_RS09460	COG1191	sigma factor activity
IMZ18_RS09465	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IMZ18_RS09475	COG0835	chemotaxis
IMZ18_RS09480	COG0643	Histidine kinase
IMZ18_RS09480	COG2198	Histidine kinase
IMZ18_RS09485	COG2201	protein-glutamate methylesterase activity
IMZ18_RS09490	COG0455	bacterial-type flagellum organization
IMZ18_RS09495	COG1419	protein localization to endoplasmic reticulum
IMZ18_RS09500	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IMZ18_RS09505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IMZ18_RS09510	COG1684	flagellar biosynthetic protein fliR
IMZ18_RS09515	COG1987	bacterial-type flagellum assembly
IMZ18_RS09520	COG1338	Plays a role in the flagellum-specific transport system
IMZ18_RS09525	COG3190	flagellar
IMZ18_RS09530	COG2201	protein-glutamate methylesterase activity
IMZ18_RS09535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IMZ18_RS09535	COG1776	CheC inhibitor of MCP methylation
IMZ18_RS09540	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IMZ18_RS09545	COG1580	Controls the rotational direction of flagella during chemotaxis
IMZ18_RS09550	COG1582	Flagellar protein (FlbD)
IMZ18_RS09555	COG4786	Flagellar basal body rod
IMZ18_RS09560	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IMZ18_RS09565	COG3144	bacterial-type flagellum assembly
IMZ18_RS09570	COG3334	PFAM MgtE intracellular
IMZ18_RS09575	COG2882	bacterial-type flagellum organization
IMZ18_RS09580	COG1157	protein secretion by the type III secretion system
IMZ18_RS09585	COG1317	bacterial-type flagellum organization
IMZ18_RS09590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IMZ18_RS09600	COG1677	Flagellar hook-basal body complex protein FliE
IMZ18_RS09605	COG1558	bacterial-type flagellum-dependent cell motility
IMZ18_RS09610	COG1815	bacterial-type flagellum-dependent cell motility
IMZ18_RS09615	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IMZ18_RS09620	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IMZ18_RS09625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IMZ18_RS09630	COG4974	Belongs to the 'phage' integrase family
IMZ18_RS09635	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IMZ18_RS09640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IMZ18_RS09645	COG0758	DNA mediated transformation
IMZ18_RS09650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IMZ18_RS09655	COG0045	succinate-CoA ligase (ADP-forming) activity
IMZ18_RS09660	COG2257	FlhB HrpN YscU SpaS Family
IMZ18_RS09670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IMZ18_RS09675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IMZ18_RS09680	COG0335	large ribosomal subunit rRNA binding
IMZ18_RS09685	COG0336	Belongs to the RNA methyltransferase TrmD family
IMZ18_RS09690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IMZ18_RS09700	COG1837	Belongs to the UPF0109 family
IMZ18_RS09705	COG0228	four-way junction DNA binding
IMZ18_RS09710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IMZ18_RS09715	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IMZ18_RS09725	COG0552	protein localization to endoplasmic reticulum
IMZ18_RS09730	COG1196	nuclear chromosome segregation
IMZ18_RS09735	COG0571	ribonuclease III activity
IMZ18_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS09750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IMZ18_RS09755	COG0416	fatty acid biosynthetic process
IMZ18_RS09760	COG1349	DNA-binding transcription factor activity
IMZ18_RS09760	COG2050	protein possibly involved in aromatic compounds catabolism
IMZ18_RS09765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IMZ18_RS09770	COG1760	l-serine dehydratase
IMZ18_RS09775	COG1760	l-serine dehydratase
IMZ18_RS09780	COG1461	Dihydroxyacetone kinase
IMZ18_RS09785	COG1302	Protein conserved in bacteria
IMZ18_RS09790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IMZ18_RS09800	COG1564	THIamine pyrophosphokinase
IMZ18_RS09805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IMZ18_RS09810	COG1162	GTPase activity
IMZ18_RS09820	COG0631	protein serine/threonine phosphatase activity
IMZ18_RS09825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IMZ18_RS09830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IMZ18_RS09830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IMZ18_RS09835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IMZ18_RS09840	COG0242	peptide deformylase activity
IMZ18_RS09845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IMZ18_RS09850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IMZ18_RS09855	COG1758	RNA polymerase activity
IMZ18_RS09860	COG0194	GDP metabolic process
IMZ18_RS09870	COG1561	YicC-like family, N-terminal region
IMZ18_RS09885	COG1648	precorrin-2 dehydrogenase activity
IMZ18_RS09890	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IMZ18_RS09895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IMZ18_RS09900	COG0529	Catalyzes the synthesis of activated sulfate
IMZ18_RS09905	COG2046	Belongs to the sulfate adenylyltransferase family
IMZ18_RS09910	COG0306	phosphate transporter
IMZ18_RS09915	COG0175	sulfate reduction
IMZ18_RS09920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IMZ18_RS09925	COG0284	orotidine-5'-phosphate decarboxylase activity
IMZ18_RS09930	COG0167	dihydroorotate dehydrogenase activity
IMZ18_RS09935	COG0543	2 iron, 2 sulfur cluster binding
IMZ18_RS09940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IMZ18_RS09945	COG0505	Belongs to the CarA family
IMZ18_RS09950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IMZ18_RS09955	COG0540	Belongs to the ATCase OTCase family
IMZ18_RS09960	COG2233	PERMEase
IMZ18_RS09965	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IMZ18_RS09970	COG0564	pseudouridine synthase activity
IMZ18_RS09975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IMZ18_RS09980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IMZ18_RS09985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IMZ18_RS09990	COG3599	regulation of cell shape
IMZ18_RS09995	COG2302	S4 RNA-binding domain
IMZ18_RS10000	COG0762	integral membrane protein
IMZ18_RS10005	COG1799	cell septum assembly
IMZ18_RS10010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IMZ18_RS10015	COG1496	oxidoreductase activity
IMZ18_RS10020	COG1873	PFAM PRC-barrel domain
IMZ18_RS10025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IMZ18_RS10030	COG1119	ATPase activity
IMZ18_RS10035	COG1191	sigma factor activity
IMZ18_RS10040	COG1191	sigma factor activity
IMZ18_RS10050	COG1404	Belongs to the peptidase S8 family
IMZ18_RS10050	COG4412	M6 family metalloprotease domain protein
IMZ18_RS10055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IMZ18_RS10065	COG3856	small basic protein
IMZ18_RS10070	COG3879	Bacterial protein of unknown function (DUF881)
IMZ18_RS10075	COG3879	Bacterial protein of unknown function (DUF881)
IMZ18_RS10080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IMZ18_RS10085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IMZ18_RS10090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMZ18_RS10095	COG0772	Belongs to the SEDS family
IMZ18_RS10100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IMZ18_RS10105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMZ18_RS10110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IMZ18_RS10115	COG0768	penicillin binding
IMZ18_RS10120	COG0768	penicillin binding
IMZ18_RS10125	COG4839	cell division protein FtsL
IMZ18_RS10130	COG0275	rRNA processing
IMZ18_RS10135	COG2001	Belongs to the MraZ family
IMZ18_RS10140	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IMZ18_RS10145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IMZ18_RS10150	COG0454	-acetyltransferase
IMZ18_RS10165	COG1399	metal-binding, possibly nucleic acid-binding protein
IMZ18_RS10175	COG1323	Belongs to the UPF0348 family
IMZ18_RS10180	COG3480	Lon protease (S16) C-terminal proteolytic domain
IMZ18_RS10185	COG1752	Esterase of the alpha-beta hydrolase superfamily
IMZ18_RS10190	COG3314	Sporulation integral membrane protein YlbJ
IMZ18_RS10195	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IMZ18_RS10200	COG0742	ribosomal rna small subunit methyltransferase
IMZ18_RS10205	COG4471	UPF0298 protein
IMZ18_RS10210	COG3679	Belongs to the UPF0342 family
IMZ18_RS10225	COG2340	Cysteine-rich secretory protein family
IMZ18_RS10230	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IMZ18_RS10240	COG3336	cytochrome c oxidase
IMZ18_RS10245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IMZ18_RS10250	COG1845	cytochrome c oxidase, subunit III
IMZ18_RS10260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IMZ18_RS10260	COG2010	Cytochrome c
IMZ18_RS10265	COG0109	protoheme IX farnesyltransferase activity
IMZ18_RS10270	COG1612	heme a metabolic process
IMZ18_RS10275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IMZ18_RS10280	COG0772	Belongs to the SEDS family
IMZ18_RS10285	COG4838	Belongs to the UPF0358 family
IMZ18_RS10290	COG2066	Belongs to the glutaminase family
IMZ18_RS10295	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IMZ18_RS10300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IMZ18_RS10310	COG4896	Protein conserved in bacteria
IMZ18_RS10320	COG1217	gtp-binding protein TYPA
IMZ18_RS10360	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IMZ18_RS10375	COG0483	inositol monophosphate 1-phosphatase activity
IMZ18_RS10385	COG4493	Belongs to the UPF0637 family
IMZ18_RS10390	COG4476	Belongs to the UPF0223 family
IMZ18_RS10395	COG1982	Orn Lys Arg decarboxylase major
IMZ18_RS10405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS10410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IMZ18_RS10415	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMZ18_RS10420	COG0022	dehydrogenase e1 component
IMZ18_RS10425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IMZ18_RS10440	COG0242	peptide deformylase activity
IMZ18_RS10445	COG0561	phosphatase activity
IMZ18_RS10450	COG5503	Protein of unknown function (DUF1447)
IMZ18_RS10455	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IMZ18_RS10460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IMZ18_RS10465	COG0569	domain protein
IMZ18_RS10470	COG2105	PFAM AIG2 family protein
IMZ18_RS10470	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IMZ18_RS10475	COG3852	Histidine kinase
IMZ18_RS10480	COG2002	toxin-antitoxin pair type II binding
IMZ18_RS10485	COG1077	Cell shape determining protein MreB Mrl
IMZ18_RS10495	COG2309	aminopeptidase activity
IMZ18_RS10500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IMZ18_RS10505	COG0488	(ABC) transporter
IMZ18_RS10515	COG0681	Belongs to the peptidase S26 family
IMZ18_RS10520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IMZ18_RS10520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS10520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IMZ18_RS10525	COG1105	Belongs to the carbohydrate kinase PfkB family
IMZ18_RS10530	COG1349	DNA-binding transcription factor activity
IMZ18_RS10535	COG0577	efflux transmembrane transporter activity
IMZ18_RS10540	COG1136	(ABC) transporter
IMZ18_RS10545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IMZ18_RS10555	COG1132	(ABC) transporter
IMZ18_RS10565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IMZ18_RS10570	COG0314	molybdopterin synthase activity
IMZ18_RS10575	COG1763	Mo-molybdopterin cofactor biosynthetic process
IMZ18_RS10580	COG0303	'Molybdopterin
IMZ18_RS10585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IMZ18_RS10590	COG0746	molybdenum cofactor guanylyltransferase activity
IMZ18_RS10610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS10615	COG0450	alkyl hydroperoxide reductase
IMZ18_RS10620	COG0668	transmembrane transport
IMZ18_RS10630	COG1473	amidohydrolase
IMZ18_RS10635	COG2171	N-acyltransferase activity
IMZ18_RS10640	COG0716	FMN binding
IMZ18_RS10650	COG0716	FMN binding
IMZ18_RS10655	COG0583	DNA-binding transcription factor activity
IMZ18_RS10660	COG0517	IMP dehydrogenase activity
IMZ18_RS10670	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IMZ18_RS10675	COG4703	Protein of unknown function (DUF1797)
IMZ18_RS10680	COG2200	EAL domain
IMZ18_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS10695	COG1408	metallophosphoesterase
IMZ18_RS10700	COG1376	ErfK ybiS ycfS ynhG family protein
IMZ18_RS10705	COG2814	Major facilitator Superfamily
IMZ18_RS10715	COG0784	Response regulator, receiver
IMZ18_RS10715	COG0835	chemotaxis
IMZ18_RS10725	COG0436	Aminotransferase
IMZ18_RS10735	COG0768	penicillin binding
IMZ18_RS10740	COG2340	Cysteine-rich secretory protein family
IMZ18_RS10745	COG3328	transposase activity
IMZ18_RS10750	COG2084	Dehydrogenase
IMZ18_RS10755	COG0840	transmembrane signaling receptor activity
IMZ18_RS10760	COG0456	acetyltransferase
IMZ18_RS10765	COG1533	DNA photolyase activity
IMZ18_RS10775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IMZ18_RS10780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS10785	COG2190	(PTS) system
IMZ18_RS10785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS10785	COG1263	PTS System
IMZ18_RS10790	COG3711	transcriptional antiterminator
IMZ18_RS10795	COG1609	Transcriptional regulator
IMZ18_RS10800	COG0006	proline dipeptidase activity
IMZ18_RS10810	COG2217	Heavy metal translocating P-type atpase
IMZ18_RS10815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS10820	COG2244	polysaccharide biosynthetic process
IMZ18_RS10825	COG3773	Cell wall hydrolase
IMZ18_RS10835	COG4873	Protein conserved in bacteria
IMZ18_RS10845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IMZ18_RS10850	COG0602	queuosine metabolic process
IMZ18_RS10855	COG0720	synthase
IMZ18_RS10860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IMZ18_RS10865	COG3949	Membrane
IMZ18_RS10870	COG0542	response to heat
IMZ18_RS10875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IMZ18_RS10880	COG1360	Flagellar Motor Protein
IMZ18_RS10885	COG1846	Transcriptional regulator
IMZ18_RS10890	COG3852	Histidine kinase
IMZ18_RS10910	COG3339	Conserved Protein
IMZ18_RS10915	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IMZ18_RS10920	COG0235	Class ii aldolase
IMZ18_RS10925	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IMZ18_RS10930	COG1850	ribulose-bisphosphate carboxylase activity
IMZ18_RS10935	COG0436	Aminotransferase
IMZ18_RS10940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IMZ18_RS10945	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IMZ18_RS10950	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IMZ18_RS10960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IMZ18_RS10965	COG5002	protein histidine kinase activity
IMZ18_RS10970	COG3594	Acyltransferase
IMZ18_RS10985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IMZ18_RS10990	COG0501	Belongs to the peptidase M48B family
IMZ18_RS11010	COG1191	sigma factor activity
IMZ18_RS11015	COG0861	Integral membrane protein TerC family
IMZ18_RS11020	COG0586	Pfam SNARE associated Golgi protein
IMZ18_RS11025	COG3300	MHYT domain
IMZ18_RS11025	COG5001	Diguanylate cyclase
IMZ18_RS11030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IMZ18_RS11035	COG3285	dna ligase
IMZ18_RS11035	COG1793	dna ligase
IMZ18_RS11040	COG0463	Glycosyl transferase, family 2
IMZ18_RS11050	COG1408	metallophosphoesterase
IMZ18_RS11055	COG0726	polysaccharide deacetylase
IMZ18_RS11060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IMZ18_RS11065	COG1846	Transcriptional regulator
IMZ18_RS11080	COG0789	Transcriptional regulator
IMZ18_RS11085	COG2239	Acts as a magnesium transporter
IMZ18_RS11095	COG3212	peptidase
IMZ18_RS11100	COG3212	peptidase
IMZ18_RS11105	COG3850	Histidine kinase
IMZ18_RS11105	COG5002	protein histidine kinase activity
IMZ18_RS11110	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS11120	COG4721	ABC-type cobalt transport system, permease component
IMZ18_RS11125	COG1122	ATPase activity
IMZ18_RS11130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IMZ18_RS11135	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS11140	COG1404	Belongs to the peptidase S8 family
IMZ18_RS11145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IMZ18_RS11150	COG0590	tRNA wobble adenosine to inosine editing
IMZ18_RS11160	COG1764	response to oxidative stress
IMZ18_RS11165	COG1846	Transcriptional regulator
IMZ18_RS11170	COG1764	response to oxidative stress
IMZ18_RS11175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IMZ18_RS11180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IMZ18_RS11185	COG0788	formyltetrahydrofolate deformylase activity
IMZ18_RS11190	COG2076	Multidrug Resistance protein
IMZ18_RS11195	COG2076	Multidrug Resistance protein
IMZ18_RS11200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS11205	COG2318	DinB family
IMZ18_RS11210	COG2323	membrane
IMZ18_RS11220	COG1017	nitric oxide dioxygenase activity
IMZ18_RS11220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IMZ18_RS11225	COG1607	acyl-coa hydrolase
IMZ18_RS11235	COG2706	6-phosphogluconolactonase activity
IMZ18_RS11240	COG4608	Belongs to the ABC transporter superfamily
IMZ18_RS11245	COG0791	NLP P60 protein
IMZ18_RS11250	COG4948	Mandelate Racemase Muconate Lactonizing
IMZ18_RS11255	COG1619	proteins homologs of microcin C7 resistance protein MccF
IMZ18_RS11260	COG4166	transmembrane transport
IMZ18_RS11265	COG0444	Belongs to the ABC transporter superfamily
IMZ18_RS11270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IMZ18_RS11275	COG0601	transmembrane transport
IMZ18_RS11280	COG2362	D-Aminopeptidase
IMZ18_RS11285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IMZ18_RS11290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ18_RS11295	COG0463	Glycosyl transferase, family 2
IMZ18_RS11300	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IMZ18_RS11305	COG0346	lactoylglutathione lyase activity
IMZ18_RS11310	COG0531	amino acid
IMZ18_RS11315	COG1392	Phosphate transport regulator
IMZ18_RS11320	COG0306	phosphate transporter
IMZ18_RS11340	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS11340	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS11380	COG3778	Protein conserved in bacteria
IMZ18_RS11385	COG3299	homolog of phage Mu protein gp47
IMZ18_RS11390	COG3628	GPW Gp25 family protein
IMZ18_RS11400	COG4193	domain, Protein
IMZ18_RS11405	COG1652	LysM domain
IMZ18_RS11460	COG4653	Phage capsid family
IMZ18_RS11465	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IMZ18_RS11470	COG5518	Phage portal protein
IMZ18_RS11475	COG1783	phage Terminase large subunit
IMZ18_RS11480	COG5484	DNA packaging
IMZ18_RS11480	COG3728	DNA packaging
IMZ18_RS11485	COG1595	DNA-templated transcription, initiation
IMZ18_RS11505	COG1484	DNA-dependent DNA replication
IMZ18_RS11510	COG1522	sequence-specific DNA binding
IMZ18_RS11520	COG1396	sequence-specific DNA binding
IMZ18_RS11525	COG2856	Zn peptidase
IMZ18_RS11530	COG3546	catalase activity
IMZ18_RS11535	COG4195	phage-related replication protein
IMZ18_RS11545	COG5632	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS11545	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS11545	COG1388	LysM domain
IMZ18_RS11560	COG0457	Tetratricopeptide repeat
IMZ18_RS11580	COG2318	DinB family
IMZ18_RS11585	COG0730	response to heat
IMZ18_RS11590	COG2721	sulfolactate sulfo-lyase activity
IMZ18_RS11595	COG0246	Mannitol dehydrogenase
IMZ18_RS11600	COG1609	Transcriptional regulator
IMZ18_RS11605	COG2271	Major facilitator Superfamily
IMZ18_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS11615	COG1312	Catalyzes the dehydration of D-mannonate
IMZ18_RS11620	COG1063	alcohol dehydrogenase
IMZ18_RS11625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IMZ18_RS11630	COG2211	Major facilitator Superfamily
IMZ18_RS11640	COG1252	NADH dehydrogenase
IMZ18_RS11655	COG0697	spore germination
IMZ18_RS11660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IMZ18_RS11665	COG0390	transport system, permease component
IMZ18_RS11670	COG1587	Uroporphyrinogen-III synthase
IMZ18_RS11680	COG1819	glycosyl
IMZ18_RS11685	COG2124	cytochrome p450
IMZ18_RS11695	COG1051	belongs to the nudix hydrolase family
IMZ18_RS11705	COG2427	Protein of unknown function (DUF1641)
IMZ18_RS11720	COG2205	protein histidine kinase activity
IMZ18_RS11725	COG5504	Zn-dependent protease
IMZ18_RS11740	COG0726	polysaccharide deacetylase
IMZ18_RS11750	COG0109	protoheme IX farnesyltransferase activity
IMZ18_RS11765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IMZ18_RS11775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS11790	COG1482	cell wall glycoprotein biosynthetic process
IMZ18_RS11795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IMZ18_RS11795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS11795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IMZ18_RS11800	COG3711	transcriptional antiterminator
IMZ18_RS11800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS11810	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IMZ18_RS11860	COG3328	transposase activity
IMZ18_RS11870	COG5444	nuclease activity
IMZ18_RS11875	COG0457	Tetratricopeptide repeat
IMZ18_RS11950	COG1396	sequence-specific DNA binding
IMZ18_RS11980	COG5505	Protein of unknown function (DUF819)
IMZ18_RS11985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS11990	COG0626	cystathionine gamma-synthase activity
IMZ18_RS11995	COG0626	cystathionine gamma-synthase activity
IMZ18_RS12000	COG2382	esterase
IMZ18_RS12005	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IMZ18_RS12010	COG2153	protein acetylation
IMZ18_RS12020	COG0210	DNA helicase
IMZ18_RS12075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IMZ18_RS12080	COG0351	phosphomethylpyrimidine kinase
IMZ18_RS12085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IMZ18_RS12090	COG2022	thiamine diphosphate biosynthetic process
IMZ18_RS12095	COG2104	thiamine diphosphate biosynthetic process
IMZ18_RS12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IMZ18_RS12105	COG0352	thiamine-phosphate diphosphorylase activity
IMZ18_RS12110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IMZ18_RS12115	COG0475	glutathione-regulated potassium exporter activity
IMZ18_RS12115	COG0569	domain protein
IMZ18_RS12120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IMZ18_RS12125	COG0564	pseudouridine synthase activity
IMZ18_RS12130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IMZ18_RS12135	COG2357	RelA SpoT domain protein
IMZ18_RS12145	COG4116	CYTH
IMZ18_RS12150	COG0741	lytic transglycosylase activity
IMZ18_RS12155	COG2346	COG2346, Truncated hemoglobins
IMZ18_RS12160	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IMZ18_RS12175	COG4469	Competence protein
IMZ18_RS12185	COG4862	establishment of competence for transformation
IMZ18_RS12195	COG0861	Integral membrane protein TerC family
IMZ18_RS12200	COG1393	Belongs to the ArsC family
IMZ18_RS12205	COG0456	acetyltransferase
IMZ18_RS12210	COG2814	Major facilitator Superfamily
IMZ18_RS12215	COG4608	Belongs to the ABC transporter superfamily
IMZ18_RS12220	COG0444	Belongs to the ABC transporter superfamily
IMZ18_RS12225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IMZ18_RS12230	COG0601	transmembrane transport
IMZ18_RS12235	COG4166	transmembrane transport
IMZ18_RS12240	COG0180	Tryptophanyl-tRNA synthetase
IMZ18_RS12250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IMZ18_RS12255	COG0601	transmembrane transport
IMZ18_RS12265	COG4608	Belongs to the ABC transporter superfamily
IMZ18_RS12270	COG0444	Belongs to the ABC transporter superfamily
IMZ18_RS12275	COG5504	Zn-dependent protease
IMZ18_RS12280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IMZ18_RS12285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IMZ18_RS12300	COG1744	ABC transporter substrate-binding protein PnrA-like
IMZ18_RS12310	COG2267	carboxylic ester hydrolase activity
IMZ18_RS12330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IMZ18_RS12335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IMZ18_RS12340	COG0505	Belongs to the CarA family
IMZ18_RS12345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IMZ18_RS12355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IMZ18_RS12360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IMZ18_RS12380	COG2151	metal-sulfur cluster biosynthetic enzyme
IMZ18_RS12385	COG1073	alpha beta
IMZ18_RS12390	COG0561	phosphatase activity
IMZ18_RS12410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS12415	COG1307	EDD domain protein, DegV family
IMZ18_RS12430	COG2996	Protein conserved in bacteria
IMZ18_RS12435	COG1666	GTP binding
IMZ18_RS12440	COG0646	methionine synthase
IMZ18_RS12440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IMZ18_RS12445	COG2153	protein acetylation
IMZ18_RS12455	COG2267	carboxylic ester hydrolase activity
IMZ18_RS12460	COG1357	PFAM Pentapeptide repeats (8 copies)
IMZ18_RS12465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS12470	COG1279	arginine transmembrane transporter activity
IMZ18_RS12475	COG2318	DinB family
IMZ18_RS12480	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS12485	COG1609	Transcriptional regulator
IMZ18_RS12490	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS12490	COG2207	Transcriptional regulator
IMZ18_RS12495	COG0534	Mate efflux family protein
IMZ18_RS12500	COG1562	ergosterol biosynthetic process
IMZ18_RS12505	COG0367	asparagine synthase
IMZ18_RS12515	COG1404	Belongs to the peptidase S8 family
IMZ18_RS12525	COG0179	Fumarylacetoacetate (FAA) hydrolase
IMZ18_RS12530	COG5337	Spore coat protein CotH
IMZ18_RS12570	COG1403	HNH endonuclease
IMZ18_RS12575	COG0419	ATPase involved in DNA repair
IMZ18_RS12580	COG0420	3'-5' exonuclease activity
IMZ18_RS12585	COG1074	ATP-dependent DNA helicase activity
IMZ18_RS12590	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IMZ18_RS12595	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IMZ18_RS12610	COG4533	DNA binding
IMZ18_RS12615	COG0477	Major facilitator Superfamily
IMZ18_RS12615	COG2814	Major facilitator Superfamily
IMZ18_RS12620	COG3180	Ammonia monooxygenase
IMZ18_RS12625	COG1609	Transcriptional regulator
IMZ18_RS12630	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ18_RS12635	COG0561	phosphatase activity
IMZ18_RS12640	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS12645	COG0738	Major facilitator superfamily
IMZ18_RS12660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IMZ18_RS12665	COG0681	Belongs to the peptidase S26 family
IMZ18_RS12670	COG0398	Pfam SNARE associated Golgi protein
IMZ18_RS12685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ18_RS12695	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS12700	COG4903	ComK protein
IMZ18_RS12710	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS12720	COG0840	transmembrane signaling receptor activity
IMZ18_RS12725	COG1268	BioY protein
IMZ18_RS12730	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ18_RS12735	COG0183	Belongs to the thiolase family
IMZ18_RS12740	COG0406	alpha-ribazole phosphatase activity
IMZ18_RS12745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IMZ18_RS12750	COG0604	alcohol dehydrogenase
IMZ18_RS12755	COG0456	acetyltransferase
IMZ18_RS12765	COG0501	Belongs to the peptidase M48B family
IMZ18_RS12775	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ18_RS12780	COG0702	epimerase
IMZ18_RS12785	COG0095	Lipoate-protein ligase
IMZ18_RS12790	COG1234	tRNA 3'-trailer cleavage
IMZ18_RS12805	COG4405	Protein conserved in bacteria
IMZ18_RS12810	COG1363	Peptidase, m42
IMZ18_RS12820	COG4377	Putative membrane peptidase family (DUF2324)
IMZ18_RS12825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IMZ18_RS12830	COG1511	domain protein
IMZ18_RS12835	COG1309	transcriptional regulator
IMZ18_RS12840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IMZ18_RS12845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IMZ18_RS12850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IMZ18_RS12855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IMZ18_RS12860	COG2329	Antibiotic biosynthesis monooxygenase
IMZ18_RS12870	COG3069	C4-dicarboxylate transmembrane transporter activity
IMZ18_RS12875	COG1473	amidohydrolase
IMZ18_RS12885	COG4473	ABC transporter
IMZ18_RS12890	COG1131	(ABC) transporter
IMZ18_RS12895	COG0537	adenosine 5'-monophosphoramidase activity
IMZ18_RS12900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IMZ18_RS12915	COG4980	gas vesicle protein
IMZ18_RS12920	COG1846	Transcriptional regulator
IMZ18_RS12950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IMZ18_RS12960	COG3481	metal-dependent phosphohydrolase, HD sub domain
IMZ18_RS12965	COG4717	serine-type aminopeptidase activity
IMZ18_RS12970	COG0420	3'-5' exonuclease activity
IMZ18_RS12975	COG1668	transmembrane transport
IMZ18_RS12980	COG4152	abc transporter atp-binding protein
IMZ18_RS12990	COG1024	Enoyl-CoA hydratase
IMZ18_RS13005	COG0475	glutathione-regulated potassium exporter activity
IMZ18_RS13010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IMZ18_RS13015	COG0561	phosphatase activity
IMZ18_RS13025	COG3679	Belongs to the UPF0342 family
IMZ18_RS13030	COG4399	Belongs to the UPF0754 family
IMZ18_RS13040	COG0189	ligase activity
IMZ18_RS13065	COG0702	epimerase
IMZ18_RS13070	COG1132	(ABC) transporter
IMZ18_RS13075	COG1132	(ABC) transporter
IMZ18_RS13085	COG0589	response to stress
IMZ18_RS13090	COG1757	Na H antiporter
IMZ18_RS13095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMZ18_RS13100	COG0726	polysaccharide deacetylase
IMZ18_RS13105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IMZ18_RS13110	COG0668	transmembrane transport
IMZ18_RS13120	COG0584	glycerophosphoryl diester phosphodiesterase
IMZ18_RS13130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IMZ18_RS13135	COG1253	flavin adenine dinucleotide binding
IMZ18_RS13145	COG0789	Transcriptional regulator
IMZ18_RS13150	COG1253	flavin adenine dinucleotide binding
IMZ18_RS13155	COG0204	Acyl-transferase
IMZ18_RS13160	COG0667	Aldo Keto reductase
IMZ18_RS13165	COG1595	DNA-templated transcription, initiation
IMZ18_RS13180	COG0456	acetyltransferase
IMZ18_RS13185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS13190	COG0733	neurotransmitter:sodium symporter activity
IMZ18_RS13195	COG0531	amino acid
IMZ18_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS13205	COG0372	Belongs to the citrate synthase family
IMZ18_RS13210	COG0583	DNA-binding transcription factor activity
IMZ18_RS13215	COG1388	LysM domain
IMZ18_RS13215	COG0791	NLP P60 protein
IMZ18_RS13220	COG1785	Belongs to the alkaline phosphatase family
IMZ18_RS13225	COG2719	SpoVR family
IMZ18_RS13230	COG0668	transmembrane transport
IMZ18_RS13235	COG1959	2 iron, 2 sulfur cluster binding
IMZ18_RS13240	COG1388	LysM domain
IMZ18_RS13240	COG0791	NLP P60 protein
IMZ18_RS13255	COG0431	NADPH-dependent FMN reductase
IMZ18_RS13260	COG2197	response regulator
IMZ18_RS13265	COG4585	Histidine kinase
IMZ18_RS13265	COG2203	Gaf domain
IMZ18_RS13270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMZ18_RS13275	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IMZ18_RS13280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IMZ18_RS13285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IMZ18_RS13290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IMZ18_RS13295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IMZ18_RS13300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IMZ18_RS13300	COG3153	acetyltransferase
IMZ18_RS13305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IMZ18_RS13310	COG0517	IMP dehydrogenase activity
IMZ18_RS13320	COG0564	pseudouridine synthase activity
IMZ18_RS13325	COG3764	Sortase (surface protein transpeptidase)
IMZ18_RS13330	COG4085	toxin activity
IMZ18_RS13330	COG1525	nuclease
IMZ18_RS13330	COG0737	Belongs to the 5'-nucleotidase family
IMZ18_RS13355	COG0457	Tetratricopeptide repeat
IMZ18_RS13375	COG0791	NLP P60 protein
IMZ18_RS13375	COG0741	lytic transglycosylase activity
IMZ18_RS13380	COG5644	endopeptidase inhibitor activity
IMZ18_RS13435	COG2946	Replication initiation factor
IMZ18_RS13440	COG0582	viral genome integration into host DNA
IMZ18_RS13465	COG5444	nuclease activity
IMZ18_RS13470	COG1823	symporter activity
IMZ18_RS13475	COG3706	GGDEF domain
IMZ18_RS13480	COG1464	Belongs to the NlpA lipoprotein family
IMZ18_RS13485	COG1278	Cold shock
IMZ18_RS13490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IMZ18_RS13495	COG1131	(ABC) transporter
IMZ18_RS13500	COG1131	(ABC) transporter
IMZ18_RS13505	COG1725	Transcriptional regulator
IMZ18_RS13525	COG0655	NAD(P)H dehydrogenase (quinone) activity
IMZ18_RS13530	COG2814	Major facilitator Superfamily
IMZ18_RS13535	COG1566	PFAM secretion protein HlyD family protein
IMZ18_RS13540	COG1846	Transcriptional regulator
IMZ18_RS13545	COG2718	Belongs to the UPF0229 family
IMZ18_RS13550	COG2766	serine protein kinase
IMZ18_RS13555	COG1664	Polymer-forming cytoskeletal
IMZ18_RS13560	COG1664	Polymer-forming cytoskeletal
IMZ18_RS13565	COG0789	Transcriptional regulator
IMZ18_RS13570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IMZ18_RS13580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IMZ18_RS13585	COG3382	B3 4 domain protein
IMZ18_RS13595	COG1476	TRANSCRIPTIONal
IMZ18_RS13605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IMZ18_RS13615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IMZ18_RS13620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IMZ18_RS13625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IMZ18_RS13630	COG1116	anion transmembrane transporter activity
IMZ18_RS13635	COG0753	catalase activity
IMZ18_RS13650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IMZ18_RS13655	COG3340	Belongs to the peptidase S51 family
IMZ18_RS13660	COG5577	PFAM Coat F domain
IMZ18_RS13670	COG4326	sporulation control protein
IMZ18_RS13780	COG0735	belongs to the Fur family
IMZ18_RS13785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IMZ18_RS13790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IMZ18_RS13795	COG4129	membrane
IMZ18_RS13800	COG1132	(ABC) transporter
IMZ18_RS13805	COG3557	Belongs to the UPF0374 family
IMZ18_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS13830	COG1194	a g-specific adenine glycosylase
IMZ18_RS13835	COG1988	membrane-bound metal-dependent
IMZ18_RS13840	COG4485	Bacterial membrane protein, YfhO
IMZ18_RS13845	COG0463	Glycosyl transferase, family 2
IMZ18_RS13850	COG0596	Alpha beta hydrolase
IMZ18_RS13855	COG5658	integral membrane protein
IMZ18_RS13860	COG3103	Sh3 type 3 domain protein
IMZ18_RS13875	COG2814	Major facilitator Superfamily
IMZ18_RS13885	COG2137	regulation of response to DNA damage stimulus
IMZ18_RS13890	COG1090	epimerase
IMZ18_RS13905	COG0778	Nitroreductase
IMZ18_RS13910	COG0384	phenazine biosynthesis protein PhzF
IMZ18_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS13920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS13925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS13930	COG0392	lysyltransferase activity
IMZ18_RS13930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IMZ18_RS13935	COG1846	Transcriptional regulator
IMZ18_RS13945	COG2318	DinB family
IMZ18_RS13950	COG2814	Major facilitator Superfamily
IMZ18_RS13955	COG1309	transcriptional regulator
IMZ18_RS13960	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
IMZ18_RS13965	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IMZ18_RS13970	COG1695	Transcriptional regulator
IMZ18_RS13975	COG0842	Transport permease protein
IMZ18_RS13980	COG0842	Transport permease protein
IMZ18_RS13980	COG1511	domain protein
IMZ18_RS13985	COG1131	(ABC) transporter
IMZ18_RS13990	COG2197	response regulator
IMZ18_RS13995	COG4585	Histidine kinase
IMZ18_RS14005	COG1082	Xylose isomerase domain protein TIM barrel
IMZ18_RS14010	COG2814	Major facilitator Superfamily
IMZ18_RS14015	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS14015	COG4977	sequence-specific DNA binding
IMZ18_RS14020	COG2514	catechol 2,3-dioxygenase activity
IMZ18_RS14025	COG2259	Doxx family
IMZ18_RS14030	COG1132	(ABC) transporter
IMZ18_RS14035	COG1132	(ABC) transporter
IMZ18_RS14040	COG5434	Belongs to the glycosyl hydrolase 28 family
IMZ18_RS14045	COG1263	PTS System
IMZ18_RS14045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS14050	COG1737	Transcriptional regulator
IMZ18_RS14055	COG1486	melibiose metabolic process
IMZ18_RS14065	COG4842	Belongs to the WXG100 family
IMZ18_RS14090	COG1742	UPF0060 membrane protein
IMZ18_RS14100	COG3284	Transcriptional regulator
IMZ18_RS14105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IMZ18_RS14110	COG0508	dehydrogenase complex catalyzes the overall conversion of
IMZ18_RS14115	COG0022	dehydrogenase e1 component
IMZ18_RS14120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IMZ18_RS14130	COG4637	Psort location Cytoplasmic, score
IMZ18_RS14135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IMZ18_RS14145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IMZ18_RS14150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IMZ18_RS14155	COG0598	Magnesium transport protein CorA
IMZ18_RS14160	COG2084	Dehydrogenase
IMZ18_RS14165	COG0726	polysaccharide deacetylase
IMZ18_RS14175	COG0535	radical SAM domain protein
IMZ18_RS14180	COG0668	transmembrane transport
IMZ18_RS14190	COG0387	Pfam Sodium calcium exchanger
IMZ18_RS14195	COG0477	Major facilitator Superfamily
IMZ18_RS14200	COG1295	ribonuclease BN
IMZ18_RS14205	COG4980	gas vesicle protein
IMZ18_RS14210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IMZ18_RS14215	COG4840	Belongs to the UPF0435 family
IMZ18_RS14220	COG2814	Major facilitator Superfamily
IMZ18_RS14230	COG0693	protein deglycase activity
IMZ18_RS14235	COG0737	Belongs to the 5'-nucleotidase family
IMZ18_RS14250	COG0778	Nitroreductase
IMZ18_RS14255	COG2188	Transcriptional regulator
IMZ18_RS14260	COG0366	Alpha amylase catalytic
IMZ18_RS14265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS14265	COG1263	PTS System
IMZ18_RS14270	COG0697	spore germination
IMZ18_RS14285	COG1115	amino acid carrier protein
IMZ18_RS14300	COG1368	sulfuric ester hydrolase activity
IMZ18_RS14305	COG1263	PTS System
IMZ18_RS14305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS14310	COG0024	Methionine aminopeptidase
IMZ18_RS14330	COG2258	MOSC domain
IMZ18_RS14335	COG1254	Belongs to the acylphosphatase family
IMZ18_RS14340	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IMZ18_RS14345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IMZ18_RS14350	COG2851	Citrate transporter
IMZ18_RS14355	COG3181	Tripartite tricarboxylate transporter family receptor
IMZ18_RS14360	COG4565	transcriptional regulatory protein
IMZ18_RS14365	COG3290	protein histidine kinase activity
IMZ18_RS14370	COG0471	metal ion transport
IMZ18_RS14375	COG3866	Pectate lyase
IMZ18_RS14385	COG0513	Belongs to the DEAD box helicase family
IMZ18_RS14390	COG0488	(ABC) transporter
IMZ18_RS14405	COG2814	Major facilitator Superfamily
IMZ18_RS14410	COG0789	Transcriptional regulator
IMZ18_RS14420	COG0488	(ABC) transporter
IMZ18_RS14425	COG0840	transmembrane signaling receptor activity
IMZ18_RS14430	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS14435	COG0531	amino acid
IMZ18_RS14440	COG1011	Hydrolase
IMZ18_RS14445	COG2223	nitrite transmembrane transporter activity
IMZ18_RS14450	COG1442	glycosyl transferase family 8
IMZ18_RS14455	COG1216	Glycosyl transferase, family 2
IMZ18_RS14460	COG1442	glycosyl transferase family 8
IMZ18_RS14465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IMZ18_RS14470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IMZ18_RS14475	COG1368	sulfuric ester hydrolase activity
IMZ18_RS14480	COG2124	cytochrome p450
IMZ18_RS14480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IMZ18_RS14495	COG3328	transposase activity
IMZ18_RS14505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IMZ18_RS14510	COG0670	Belongs to the BI1 family
IMZ18_RS14515	COG5583	Uncharacterized small protein (DUF2292)
IMZ18_RS14530	COG0346	lactoylglutathione lyase activity
IMZ18_RS14535	COG2329	Antibiotic biosynthesis monooxygenase
IMZ18_RS14540	COG2323	membrane
IMZ18_RS14545	COG1486	melibiose metabolic process
IMZ18_RS14550	COG0395	ABC-type sugar transport system, permease component
IMZ18_RS14555	COG4209	transmembrane transport
IMZ18_RS14560	COG1653	transport
IMZ18_RS14575	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS14580	COG3401	FG-GAP repeat protein
IMZ18_RS14585	COG3401	FG-GAP repeat protein
IMZ18_RS14590	COG5578	integral membrane protein
IMZ18_RS14600	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS14605	COG2207	Transcriptional regulator
IMZ18_RS14610	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IMZ18_RS14615	COG0395	ABC-type sugar transport system, permease component
IMZ18_RS14620	COG1175	transmembrane transport
IMZ18_RS14625	COG1653	transport
IMZ18_RS14635	COG2972	Histidine kinase
IMZ18_RS14640	COG5578	integral membrane protein
IMZ18_RS14650	COG0454	-acetyltransferase
IMZ18_RS14655	COG3546	catalase activity
IMZ18_RS14670	COG1309	transcriptional regulator
IMZ18_RS14680	COG0217	transcriptional regulatory protein
IMZ18_RS14690	COG0457	Tetratricopeptide repeat
IMZ18_RS14700	COG5444	nuclease activity
IMZ18_RS14730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IMZ18_RS14735	COG1597	lipid kinase activity
IMZ18_RS14740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IMZ18_RS14745	COG1309	transcriptional regulator
IMZ18_RS14755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMZ18_RS14760	COG0154	amidase activity
IMZ18_RS14765	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IMZ18_RS14770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ18_RS14775	COG1285	pathogenesis
IMZ18_RS14780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IMZ18_RS14795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IMZ18_RS14800	COG0210	DNA helicase
IMZ18_RS14805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IMZ18_RS14810	COG0069	glutamate synthase activity
IMZ18_RS14815	COG4496	protein, YerC YecD
IMZ18_RS14820	COG1470	cell adhesion involved in biofilm formation
IMZ18_RS14825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IMZ18_RS14835	COG0531	amino acid
IMZ18_RS14840	COG1522	sequence-specific DNA binding
IMZ18_RS14845	COG0151	Belongs to the GarS family
IMZ18_RS14855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IMZ18_RS14860	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IMZ18_RS14865	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IMZ18_RS14870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMZ18_RS14875	COG0047	phosphoribosylformylglycinamidine synthase activity
IMZ18_RS14880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IMZ18_RS14885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IMZ18_RS14890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IMZ18_RS14895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IMZ18_RS14900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IMZ18_RS14910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IMZ18_RS14920	COG3064	Membrane
IMZ18_RS14925	COG2252	PERMEase
IMZ18_RS14935	COG0519	Catalyzes the synthesis of GMP from XMP
IMZ18_RS14935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IMZ18_RS14940	COG1305	Transglutaminase-like
IMZ18_RS14945	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
IMZ18_RS14950	COG0714	Associated with various cellular activities
IMZ18_RS14955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IMZ18_RS14965	COG1113	amino acid transport
IMZ18_RS14970	COG2132	Multicopper oxidase
IMZ18_RS14980	COG2267	carboxylic ester hydrolase activity
IMZ18_RS15000	COG0823	Involved in the tonB-independent uptake of proteins
IMZ18_RS15005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IMZ18_RS15010	COG1063	alcohol dehydrogenase
IMZ18_RS15015	COG2814	Major facilitator Superfamily
IMZ18_RS15025	COG4260	virion core protein, lumpy skin disease virus
IMZ18_RS15030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IMZ18_RS15035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IMZ18_RS15045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMZ18_RS15050	COG2211	Major facilitator Superfamily
IMZ18_RS15055	COG1063	alcohol dehydrogenase
IMZ18_RS15060	COG0457	Tetratricopeptide repeat
IMZ18_RS15075	COG0459	protein refolding
IMZ18_RS15085	COG1266	CAAX protease self-immunity
IMZ18_RS15095	COG0805	protein transport
IMZ18_RS15100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMZ18_RS15105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IMZ18_RS15110	COG0315	cyclic pyranopterin monophosphate synthase activity
IMZ18_RS15115	COG0488	(ABC) transporter
IMZ18_RS15120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IMZ18_RS15125	COG0456	acetyltransferase
IMZ18_RS15130	COG1214	PFAM Peptidase M22, glycoprotease
IMZ18_RS15135	COG0802	atpase or kinase
IMZ18_RS15140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IMZ18_RS15185	COG4124	Belongs to the glycosyl hydrolase 26 family
IMZ18_RS15195	COG1940	carbohydrate kinase activity
IMZ18_RS15200	COG2188	Transcriptional regulator
IMZ18_RS15205	COG2723	6-phospho-beta-galactosidase activity
IMZ18_RS15220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IMZ18_RS15225	COG2814	Major facilitator Superfamily
IMZ18_RS15230	COG1388	LysM domain
IMZ18_RS15235	COG1078	dGTPase activity
IMZ18_RS15240	COG0454	-acetyltransferase
IMZ18_RS15250	COG5646	InterPro IPR014922
IMZ18_RS15255	COG1785	Belongs to the alkaline phosphatase family
IMZ18_RS15265	COG1819	glycosyl
IMZ18_RS15270	COG1388	LysM domain
IMZ18_RS15270	COG3858	chitin binding
IMZ18_RS15275	COG1802	Transcriptional regulator
IMZ18_RS15280	COG0730	response to heat
IMZ18_RS15285	COG2814	Major facilitator Superfamily
IMZ18_RS15290	COG1846	Transcriptional regulator
IMZ18_RS15295	COG0778	Nitroreductase
IMZ18_RS15300	COG2409	Drug exporters of the RND superfamily
IMZ18_RS15300	COG1033	growth of symbiont in host cell
IMZ18_RS15305	COG1846	Transcriptional regulator
IMZ18_RS15310	COG2318	DinB family
IMZ18_RS15315	COG1113	amino acid transport
IMZ18_RS15320	COG0488	(ABC) transporter
IMZ18_RS15325	COG0456	acetyltransferase
IMZ18_RS15335	COG1309	transcriptional regulator
IMZ18_RS15350	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ18_RS15355	COG2323	membrane
IMZ18_RS15380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS15385	COG2259	Doxx family
IMZ18_RS15390	COG0346	lactoylglutathione lyase activity
IMZ18_RS15395	COG0778	Nitroreductase
IMZ18_RS15400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IMZ18_RS15405	COG0789	Transcriptional regulator
IMZ18_RS15405	COG4978	Transcriptional regulator
IMZ18_RS15420	COG2409	Drug exporters of the RND superfamily
IMZ18_RS15425	COG2197	response regulator
IMZ18_RS15430	COG4585	Histidine kinase
IMZ18_RS15445	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IMZ18_RS15450	COG0640	Transcriptional regulator
IMZ18_RS15455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IMZ18_RS15460	COG0076	glutamate decarboxylase activity
IMZ18_RS15465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS15470	COG0697	spore germination
IMZ18_RS15475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS15485	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IMZ18_RS15490	COG0640	Transcriptional regulator
IMZ18_RS15495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS15505	COG3545	Serine hydrolase
IMZ18_RS15510	COG2030	dehydratase
IMZ18_RS15515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS15520	COG0697	spore germination
IMZ18_RS15525	COG1309	transcriptional regulator
IMZ18_RS15530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS15545	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IMZ18_RS15565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS15570	COG2207	Transcriptional regulator
IMZ18_RS15570	COG3708	Transcriptional regulator
IMZ18_RS15580	COG2207	Transcriptional regulator
IMZ18_RS15580	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS15585	COG0697	spore germination
IMZ18_RS15590	COG1329	Transcriptional regulator
IMZ18_RS15595	COG1278	Cold shock
IMZ18_RS15600	COG0693	protein deglycase activity
IMZ18_RS15620	COG1476	TRANSCRIPTIONal
IMZ18_RS15625	COG5444	nuclease activity
IMZ18_RS15635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS15640	COG0583	DNA-binding transcription factor activity
IMZ18_RS15670	COG0457	Tetratricopeptide repeat
IMZ18_RS15685	COG0741	lytic transglycosylase activity
IMZ18_RS15685	COG0791	NLP P60 protein
IMZ18_RS15695	COG5644	endopeptidase inhibitor activity
IMZ18_RS15705	COG0433	COG0433 Predicted ATPase
IMZ18_RS15745	COG2946	Replication initiation factor
IMZ18_RS15750	COG1674	ftsk spoiiie
IMZ18_RS15780	COG1396	sequence-specific DNA binding
IMZ18_RS15785	COG2856	Zn peptidase
IMZ18_RS15790	COG0582	viral genome integration into host DNA
IMZ18_RS15830	COG3091	SprT-like family
IMZ18_RS15840	COG2183	response to ionizing radiation
IMZ18_RS15845	COG1846	Transcriptional regulator
IMZ18_RS15850	COG1673	EVE domain
IMZ18_RS15865	COG2208	phosphoserine phosphatase activity
IMZ18_RS15870	COG1191	sigma factor activity
IMZ18_RS15875	COG2172	sigma factor antagonist activity
IMZ18_RS15880	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS15885	COG2208	phosphoserine phosphatase activity
IMZ18_RS15890	COG2172	sigma factor antagonist activity
IMZ18_RS15895	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS15900	COG1366	Belongs to the anti-sigma-factor antagonist family
IMZ18_RS15905	COG2337	Toxic component of a toxin-antitoxin (TA) module
IMZ18_RS15910	COG0864	Transcriptional regulator
IMZ18_RS15915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IMZ18_RS15920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IMZ18_RS15925	COG0736	holo-[acyl-carrier-protein] synthase activity
IMZ18_RS15930	COG0705	Rhomboid family
IMZ18_RS15935	COG3428	Bacterial PH domain
IMZ18_RS15940	COG3402	PFAM membrane-flanked domain
IMZ18_RS15945	COG0513	Belongs to the DEAD box helicase family
IMZ18_RS15950	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IMZ18_RS15955	COG1181	Belongs to the D-alanine--D-alanine ligase family
IMZ18_RS15960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IMZ18_RS15965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IMZ18_RS15980	COG1960	acyl-CoA dehydrogenase activity
IMZ18_RS15990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IMZ18_RS15995	COG1131	(ABC) transporter
IMZ18_RS16005	COG0628	permease
IMZ18_RS16010	COG1301	dicarboxylic acid transport
IMZ18_RS16015	COG4565	transcriptional regulatory protein
IMZ18_RS16020	COG3290	protein histidine kinase activity
IMZ18_RS16025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IMZ18_RS16030	COG3546	catalase activity
IMZ18_RS16035	COG2329	Antibiotic biosynthesis monooxygenase
IMZ18_RS16040	COG0662	Cupin 2, conserved barrel domain protein
IMZ18_RS16045	COG3729	General stress protein
IMZ18_RS16050	COG2217	Heavy metal translocating P-type atpase
IMZ18_RS16055	COG4876	unkown
IMZ18_RS16060	COG2261	transglycosylase associated protein
IMZ18_RS16065	COG1914	H( )-stimulated, divalent metal cation uptake system
IMZ18_RS16090	COG0028	Belongs to the TPP enzyme family
IMZ18_RS16095	COG0494	nUDIX hydrolase
IMZ18_RS16100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IMZ18_RS16100	COG0551	DNA topoisomerase type I activity
IMZ18_RS16105	COG1522	sequence-specific DNA binding
IMZ18_RS16110	COG2814	Major facilitator Superfamily
IMZ18_RS16120	COG3871	stress protein (general stress protein 26)
IMZ18_RS16125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS16140	COG2226	methyltransferase
IMZ18_RS16145	COG0318	PFAM AMP-dependent synthetase and ligase
IMZ18_RS16150	COG3711	transcriptional antiterminator
IMZ18_RS16155	COG4989	oxidoreductase activity
IMZ18_RS16160	COG0768	penicillin binding
IMZ18_RS16165	COG2329	Antibiotic biosynthesis monooxygenase
IMZ18_RS16175	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS16180	COG1414	Transcriptional regulator
IMZ18_RS16185	COG1984	allophanate hydrolase subunit 2
IMZ18_RS16190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IMZ18_RS16195	COG4336	lyase activity
IMZ18_RS16200	COG1914	H( )-stimulated, divalent metal cation uptake system
IMZ18_RS16205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IMZ18_RS16210	COG0561	phosphatase activity
IMZ18_RS16220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IMZ18_RS16230	COG0681	Belongs to the peptidase S26 family
IMZ18_RS16235	COG0473	3-isopropylmalate dehydrogenase activity
IMZ18_RS16240	COG0246	Mannitol dehydrogenase
IMZ18_RS16255	COG1349	DNA-binding transcription factor activity
IMZ18_RS16260	COG1276	copper resistance
IMZ18_RS16260	COG2372	response to copper ion
IMZ18_RS16265	COG4549	nuclear export factor GLE1
IMZ18_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS16280	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS16285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IMZ18_RS16290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS16295	COG0640	Transcriptional regulator
IMZ18_RS16300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IMZ18_RS16305	COG0778	Nitroreductase
IMZ18_RS16310	COG1309	transcriptional regulator
IMZ18_RS16315	COG2814	Major facilitator Superfamily
IMZ18_RS16325	COG4607	ABC-type enterochelin transport system periplasmic component
IMZ18_RS16330	COG4604	ABC transporter, ATP-binding protein
IMZ18_RS16335	COG4605	iron ion homeostasis
IMZ18_RS16340	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS16345	COG0527	aspartate kinase activity
IMZ18_RS16365	COG0457	Tetratricopeptide repeat
IMZ18_RS16370	COG3850	Histidine kinase
IMZ18_RS16370	COG5002	protein histidine kinase activity
IMZ18_RS16375	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS16380	COG0577	efflux transmembrane transporter activity
IMZ18_RS16385	COG1136	(ABC) transporter
IMZ18_RS16390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IMZ18_RS16410	COG5434	Belongs to the glycosyl hydrolase 28 family
IMZ18_RS16415	COG3104	oligopeptide transport
IMZ18_RS16420	COG0596	Alpha beta hydrolase
IMZ18_RS16435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IMZ18_RS16440	COG0163	prenyltransferase activity
IMZ18_RS16445	COG0583	DNA-binding transcription factor activity
IMZ18_RS16450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMZ18_RS16455	COG0765	amino acid transport
IMZ18_RS16460	COG1126	abc transporter atp-binding protein
IMZ18_RS16465	COG2364	Membrane
IMZ18_RS16475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IMZ18_RS16480	COG0697	spore germination
IMZ18_RS16495	COG2814	Major facilitator Superfamily
IMZ18_RS16500	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IMZ18_RS16510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IMZ18_RS16515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IMZ18_RS16520	COG1733	regulation of RNA biosynthetic process
IMZ18_RS16525	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IMZ18_RS16530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IMZ18_RS16540	COG3209	COG3209 Rhs family protein
IMZ18_RS16550	COG2723	6-phospho-beta-galactosidase activity
IMZ18_RS16565	COG1846	Transcriptional regulator
IMZ18_RS16575	COG1714	RDD family
IMZ18_RS16585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMZ18_RS16590	COG0765	amino acid transport
IMZ18_RS16605	COG1376	ErfK ybiS ycfS ynhG family protein
IMZ18_RS16615	COG2223	nitrite transmembrane transporter activity
IMZ18_RS16620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IMZ18_RS16625	COG0243	molybdopterin cofactor binding
IMZ18_RS16630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IMZ18_RS16635	COG2146	nitrite reductase [NAD(P)H] activity
IMZ18_RS16640	COG1587	Uroporphyrinogen-III synthase
IMZ18_RS16640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IMZ18_RS16645	COG0492	ferredoxin-NADP+ reductase activity
IMZ18_RS16650	COG2267	carboxylic ester hydrolase activity
IMZ18_RS16655	COG0701	Predicted permease
IMZ18_RS16660	COG3689	TIGRFAM TIGR03943 family protein
IMZ18_RS16665	COG2508	Transcriptional regulator
IMZ18_RS16670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ18_RS16675	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS16680	COG0506	proline dehydrogenase activity
IMZ18_RS16685	COG3541	Predicted nucleotidyltransferase
IMZ18_RS16690	COG3458	cephalosporin-C deacetylase activity
IMZ18_RS16695	COG0583	DNA-binding transcription factor activity
IMZ18_RS16700	COG2226	methyltransferase
IMZ18_RS16710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IMZ18_RS16715	COG1660	Displays ATPase and GTPase activities
IMZ18_RS16720	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IMZ18_RS16735	COG3403	YqcI/YcgG family
IMZ18_RS16750	COG0039	L-malate dehydrogenase activity
IMZ18_RS16765	COG1288	antiporter activity
IMZ18_RS16770	COG1473	amidohydrolase
IMZ18_RS16775	COG2113	Glycine betaine
IMZ18_RS16780	COG4176	ABC-type proline glycine betaine transport system permease component
IMZ18_RS16785	COG0517	IMP dehydrogenase activity
IMZ18_RS16785	COG4175	Glycine betaine
IMZ18_RS16790	COG0640	Transcriptional regulator
IMZ18_RS16795	COG2814	Major facilitator Superfamily
IMZ18_RS16800	COG0477	Major facilitator Superfamily
IMZ18_RS16810	COG3853	Toxic anion resistance protein (TelA)
IMZ18_RS16820	COG0861	Integral membrane protein TerC family
IMZ18_RS16825	COG2310	stress, protein
IMZ18_RS16830	COG2310	stress, protein
IMZ18_RS16835	COG2310	stress, protein
IMZ18_RS16845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IMZ18_RS16850	COG1121	(ABC) transporter
IMZ18_RS16855	COG0803	Belongs to the bacterial solute-binding protein 9 family
IMZ18_RS16860	COG0366	Alpha amylase catalytic
IMZ18_RS16865	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS16875	COG1876	peptidase activity
IMZ18_RS16880	COG1595	DNA-templated transcription, initiation
IMZ18_RS16885	COG1595	DNA-templated transcription, initiation
IMZ18_RS16905	COG0667	Aldo Keto reductase
IMZ18_RS16910	COG1668	transmembrane transport
IMZ18_RS16920	COG3279	Response regulator of the LytR AlgR family
IMZ18_RS16930	COG1405	negative regulation of cell septum assembly
IMZ18_RS16930	COG3012	SEC-C Motif Domain Protein
IMZ18_RS16935	COG1714	RDD family
IMZ18_RS16940	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IMZ18_RS16945	COG0252	asparaginase activity
IMZ18_RS16950	COG1309	transcriptional regulator
IMZ18_RS16955	COG0477	Major facilitator Superfamily
IMZ18_RS16960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IMZ18_RS16965	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IMZ18_RS16970	COG0805	protein transport
IMZ18_RS16975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IMZ18_RS16980	COG3540	Alkaline phosphatase
IMZ18_RS16990	COG2304	oxidoreductase activity
IMZ18_RS16995	COG3773	Cell wall hydrolase
IMZ18_RS17015	COG1131	(ABC) transporter
IMZ18_RS17020	COG2205	protein histidine kinase activity
IMZ18_RS17025	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS17030	COG0697	spore germination
IMZ18_RS17040	COG3173	Aminoglycoside phosphotransferase
IMZ18_RS17045	COG2721	sulfolactate sulfo-lyase activity
IMZ18_RS17050	COG2186	Transcriptional regulator
IMZ18_RS17055	COG4948	Mandelate Racemase Muconate Lactonizing
IMZ18_RS17060	COG2271	Major facilitator Superfamily
IMZ18_RS17065	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS17070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IMZ18_RS17075	COG0784	Response regulator, receiver
IMZ18_RS17080	COG4191	Histidine kinase
IMZ18_RS17085	COG2066	Belongs to the glutaminase family
IMZ18_RS17095	COG2040	homocysteine
IMZ18_RS17100	COG0833	amino acid
IMZ18_RS17105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMZ18_RS17115	COG2188	Transcriptional regulator
IMZ18_RS17120	COG0363	glucosamine-6-phosphate deaminase activity
IMZ18_RS17125	COG2190	(PTS) system
IMZ18_RS17125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS17125	COG1263	PTS System
IMZ18_RS17130	COG1301	dicarboxylic acid transport
IMZ18_RS17140	COG1054	Belongs to the UPF0176 family
IMZ18_RS17145	COG2207	Transcriptional regulator
IMZ18_RS17150	COG2312	Erythromycin esterase
IMZ18_RS17160	COG0688	phosphatidylethanolamine metabolic process
IMZ18_RS17165	COG0586	Pfam SNARE associated Golgi protein
IMZ18_RS17170	COG1183	phosphatidylcholine synthase activity
IMZ18_RS17175	COG0596	Alpha beta hydrolase
IMZ18_RS17185	COG3591	Belongs to the peptidase S1B family
IMZ18_RS17190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IMZ18_RS17215	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS17215	COG2207	Transcriptional regulator
IMZ18_RS17220	COG0697	spore germination
IMZ18_RS17225	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS17240	COG0456	acetyltransferase
IMZ18_RS17240	COG1846	Transcriptional regulator
IMZ18_RS17250	COG2271	Major facilitator Superfamily
IMZ18_RS17255	COG0584	glycerophosphoryl diester phosphodiesterase
IMZ18_RS17260	COG0531	amino acid
IMZ18_RS17270	COG2124	cytochrome p450
IMZ18_RS17275	COG2602	Beta-lactamase
IMZ18_RS17290	COG1113	amino acid transport
IMZ18_RS17305	COG0515	serine threonine protein kinase
IMZ18_RS17315	COG0642	Histidine kinase
IMZ18_RS17325	COG5609	conserved protein (DUF2294)
IMZ18_RS17335	COG0288	reversible hydration of carbon dioxide
IMZ18_RS17340	COG3002	Belongs to the UPF0753 family
IMZ18_RS17345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IMZ18_RS17350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IMZ18_RS17355	COG2169	Transcriptional regulator
IMZ18_RS17370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IMZ18_RS17375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IMZ18_RS17380	COG4856	YbbR-like protein
IMZ18_RS17385	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IMZ18_RS17390	COG5662	AntiSigma factor
IMZ18_RS17395	COG1595	DNA-templated transcription, initiation
IMZ18_RS17425	COG1683	Conserved Protein
IMZ18_RS17430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IMZ18_RS17435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IMZ18_RS17440	COG1737	Transcriptional regulator
IMZ18_RS17445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS17445	COG1263	PTS System
IMZ18_RS17450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IMZ18_RS17455	COG1472	Belongs to the glycosyl hydrolase 3 family
IMZ18_RS17460	COG3876	Protein conserved in bacteria
IMZ18_RS17465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS17465	COG2207	Transcriptional regulator
IMZ18_RS17470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS17475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS17480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IMZ18_RS17485	COG2819	hydrolase of the alpha beta superfamily
IMZ18_RS17490	COG0385	Bile acid
IMZ18_RS17495	COG0659	secondary active sulfate transmembrane transporter activity
IMZ18_RS17575	COG0726	polysaccharide deacetylase
IMZ18_RS17580	COG2194	sulfuric ester hydrolase activity
IMZ18_RS17590	COG0489	protein tyrosine kinase activity
IMZ18_RS17595	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS17605	COG2226	methyltransferase
IMZ18_RS17610	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IMZ18_RS17615	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IMZ18_RS17620	COG0101	tRNA pseudouridine synthase activity
IMZ18_RS17625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IMZ18_RS17630	COG1122	ATPase activity
IMZ18_RS17635	COG1122	ATPase activity
IMZ18_RS17640	COG0203	ribosomal protein L17
IMZ18_RS17645	COG0202	RNA polymerase activity
IMZ18_RS17650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IMZ18_RS17655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IMZ18_RS17660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IMZ18_RS17675	COG0024	Methionine aminopeptidase
IMZ18_RS17680	COG0563	adenylate kinase activity
IMZ18_RS17685	COG0201	protein transport
IMZ18_RS17690	COG0200	Binds to the 23S rRNA
IMZ18_RS17700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IMZ18_RS17705	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IMZ18_RS17710	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IMZ18_RS17715	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IMZ18_RS17725	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IMZ18_RS17735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IMZ18_RS17740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IMZ18_RS17750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IMZ18_RS17755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IMZ18_RS17770	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IMZ18_RS17780	COG0088	Forms part of the polypeptide exit tunnel
IMZ18_RS17785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IMZ18_RS17795	COG0596	Alpha beta hydrolase
IMZ18_RS17800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IMZ18_RS17805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IMZ18_RS17810	COG0049	tRNA binding
IMZ18_RS17815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IMZ18_RS17820	COG1358	cellular component organization or biogenesis
IMZ18_RS17825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IMZ18_RS17830	COG0085	RNA polymerase activity
IMZ18_RS17835	COG2813	Specifically methylates the guanine in position
IMZ18_RS17845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IMZ18_RS17850	COG0081	regulation of translation
IMZ18_RS17860	COG0250	Participates in transcription elongation, termination and antitermination
IMZ18_RS17865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IMZ18_RS17875	COG1595	DNA-templated transcription, initiation
IMZ18_RS17880	COG3688	RNA-binding protein containing a PIN domain
IMZ18_RS17885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IMZ18_RS17890	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IMZ18_RS17895	COG0215	cysteine-tRNA ligase activity
IMZ18_RS17900	COG1045	serine acetyltransferase
IMZ18_RS17905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IMZ18_RS17910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IMZ18_RS17915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IMZ18_RS17920	COG4956	integral membrane protein (PIN domain superfamily)
IMZ18_RS17925	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IMZ18_RS17930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IMZ18_RS17935	COG0542	response to heat
IMZ18_RS17940	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IMZ18_RS17945	COG3880	PFAM UvrB UvrC protein
IMZ18_RS17950	COG4463	regulation of RNA biosynthetic process
IMZ18_RS18025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IMZ18_RS18030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IMZ18_RS18035	COG1396	sequence-specific DNA binding
IMZ18_RS18040	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IMZ18_RS18045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IMZ18_RS18050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IMZ18_RS18055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMZ18_RS18065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IMZ18_RS18070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IMZ18_RS18075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IMZ18_RS18080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IMZ18_RS18085	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IMZ18_RS18090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IMZ18_RS18095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IMZ18_RS18100	COG0037	tRNA processing
IMZ18_RS18110	COG2304	oxidoreductase activity
IMZ18_RS18115	COG2208	phosphoserine phosphatase activity
IMZ18_RS18130	COG1098	S1 RNA binding domain
IMZ18_RS18135	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IMZ18_RS18150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IMZ18_RS18155	COG3956	TIGRFAM MazG family protein
IMZ18_RS18160	COG2244	polysaccharide biosynthetic process
IMZ18_RS18165	COG2002	toxin-antitoxin pair type II binding
IMZ18_RS18170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IMZ18_RS18180	COG0193	aminoacyl-tRNA hydrolase activity
IMZ18_RS18185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IMZ18_RS18190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IMZ18_RS18195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IMZ18_RS18200	COG2088	sporulation resulting in formation of a cellular spore
IMZ18_RS18205	COG0251	oxidation-reduction process
IMZ18_RS18210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IMZ18_RS18215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IMZ18_RS18225	COG4466	Protein conserved in bacteria
IMZ18_RS18235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IMZ18_RS18240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IMZ18_RS18245	COG3584	3D domain protein
IMZ18_RS18245	COG3583	domain protein
IMZ18_RS18250	COG0084	hydrolase, TatD family'
IMZ18_RS18255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ18_RS18255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IMZ18_RS18260	COG2002	toxin-antitoxin pair type II binding
IMZ18_RS18265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IMZ18_RS18270	COG2827	Endonuclease containing a URI domain
IMZ18_RS18275	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IMZ18_RS18280	COG4467	Involved in initiation control of chromosome replication
IMZ18_RS18285	COG1774	PSP1 C-terminal conserved region
IMZ18_RS18290	COG0470	DNA polymerase III
IMZ18_RS18295	COG1728	Protein conserved in bacteria
IMZ18_RS18300	COG3870	Protein conserved in bacteria
IMZ18_RS18305	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IMZ18_RS18310	COG1982	Orn Lys Arg decarboxylase major
IMZ18_RS18315	COG3853	Toxic anion resistance protein (TelA)
IMZ18_RS18320	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IMZ18_RS18365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IMZ18_RS18370	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IMZ18_RS18375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IMZ18_RS18385	COG0590	tRNA wobble adenosine to inosine editing
IMZ18_RS18390	COG1335	isochorismatase
IMZ18_RS18395	COG1388	LysM domain
IMZ18_RS18395	COG3858	chitin binding
IMZ18_RS18400	COG1428	Deoxynucleoside kinase
IMZ18_RS18405	COG1428	Deoxynucleoside kinase
IMZ18_RS18415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IMZ18_RS18420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IMZ18_RS18425	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IMZ18_RS18430	COG1686	Belongs to the peptidase S11 family
IMZ18_RS18435	COG0516	GMP reductase activity
IMZ18_RS18435	COG0517	IMP dehydrogenase activity
IMZ18_RS18475	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IMZ18_RS18480	COG0187	DNA topoisomerase II activity
IMZ18_RS18490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IMZ18_RS18495	COG2501	S4 domain
IMZ18_RS18500	COG0592	DNA-directed DNA polymerase activity
IMZ18_RS18505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IMZ18_RS18515	COG0594	ribonuclease P activity
IMZ18_RS18520	COG0706	membrane insertase activity
IMZ18_RS18525	COG1847	R3H domain protein
IMZ18_RS18530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IMZ18_RS18535	COG0445	tRNA wobble uridine modification
IMZ18_RS18540	COG0357	Ribosomal RNA small subunit methyltransferase G
IMZ18_RS18545	COG1475	DNA binding
IMZ18_RS18555	COG1192	Involved in chromosome partitioning
IMZ18_RS18560	COG1475	DNA binding
IMZ18_RS18570	COG3949	Membrane
IMZ18_RS18575	COG4481	Protein conserved in bacteria
IMZ18_RS18580	COG0243	molybdopterin cofactor binding
IMZ18_RS18585	COG0012	GTP binding
IMZ18_RS18590	COG0360	Binds together with S18 to 16S ribosomal RNA
IMZ18_RS18595	COG0629	single-stranded DNA binding
IMZ18_RS18600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IMZ18_RS18605	COG0708	Exodeoxyribonuclease III
IMZ18_RS18620	COG0542	response to heat
IMZ18_RS18625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IMZ18_RS18630	COG0346	lactoylglutathione lyase activity
IMZ18_RS18635	COG2814	Major facilitator Superfamily
IMZ18_RS18635	COG0477	Major facilitator Superfamily
IMZ18_RS18640	COG1266	CAAX protease self-immunity
IMZ18_RS18650	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IMZ18_RS18655	COG1331	Highly conserved protein containing a thioredoxin domain
IMZ18_RS18660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IMZ18_RS18665	COG2315	Protein conserved in bacteria
IMZ18_RS18670	COG0456	acetyltransferase
IMZ18_RS18675	COG2364	Membrane
IMZ18_RS18680	COG2153	protein acetylation
IMZ18_RS18685	COG1846	Transcriptional regulator
IMZ18_RS18700	COG1357	PFAM Pentapeptide repeats (8 copies)
IMZ18_RS18705	COG4319	ketosteroid isomerase
IMZ18_RS18715	COG4978	Transcriptional regulator
IMZ18_RS18715	COG0789	Transcriptional regulator
IMZ18_RS18720	COG2271	Major facilitator Superfamily
IMZ18_RS18740	COG1227	inorganic diphosphatase activity
IMZ18_RS18745	COG1733	regulation of RNA biosynthetic process
IMZ18_RS18760	COG4241	membrane
IMZ18_RS18765	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IMZ18_RS18770	COG0359	binds to the 23S rRNA
IMZ18_RS18775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IMZ18_RS18780	COG2807	transmembrane transport
IMZ18_RS18785	COG3093	addiction module antidote protein HigA
IMZ18_RS18800	COG0305	Participates in initiation and elongation during chromosome replication
IMZ18_RS18805	COG0346	lactoylglutathione lyase activity
IMZ18_RS18835	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS18840	COG5002	protein histidine kinase activity
IMZ18_RS18845	COG4863	YycH protein
IMZ18_RS18850	COG4853	Protein conserved in bacteria
IMZ18_RS18855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IMZ18_RS18860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ18_RS18875	COG3829	transcription factor binding
IMZ18_RS18880	COG0640	Transcriptional regulator
IMZ18_RS18885	COG5658	integral membrane protein
IMZ18_RS18905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IMZ18_RS18910	COG0833	amino acid
IMZ18_RS18915	COG0010	Belongs to the arginase family
IMZ18_RS18925	COG0457	Tetratricopeptide repeat
IMZ18_RS18930	COG0456	acetyltransferase
IMZ18_RS18935	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IMZ18_RS18955	COG1063	alcohol dehydrogenase
IMZ18_RS18970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IMZ18_RS19005	COG2963	transposase activity
IMZ18_RS19035	COG0210	DNA helicase
IMZ18_RS19065	COG0071	Belongs to the small heat shock protein (HSP20) family
IMZ18_RS19080	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IMZ18_RS19085	COG1131	(ABC) transporter
IMZ18_RS19095	COG2188	Transcriptional regulator
IMZ18_RS19105	COG2723	6-phospho-beta-galactosidase activity
IMZ18_RS19110	COG3634	alkyl hydroperoxide reductase activity
IMZ18_RS19115	COG0450	alkyl hydroperoxide reductase
IMZ18_RS19120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IMZ18_RS19130	COG1070	Carbohydrate kinase
IMZ18_RS19135	COG1802	Transcriptional regulator
IMZ18_RS19140	COG1929	Belongs to the glycerate kinase type-1 family
IMZ18_RS19145	COG5039	Polysaccharide pyruvyl transferase
IMZ18_RS19150	COG1346	cytolysis
IMZ18_RS19155	COG1380	Effector of murein hydrolase LrgA
IMZ18_RS19160	COG1846	Transcriptional regulator
IMZ18_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS19170	COG1309	transcriptional regulator
IMZ18_RS19175	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS19230	COG0326	Molecular chaperone. Has ATPase activity
IMZ18_RS19260	COG0667	Aldo Keto reductase
IMZ18_RS19265	COG1349	DNA-binding transcription factor activity
IMZ18_RS19285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMZ18_RS19290	COG3962	Belongs to the TPP enzyme family
IMZ18_RS19295	COG1082	Xylose isomerase domain protein TIM barrel
IMZ18_RS19300	COG2814	Major facilitator Superfamily
IMZ18_RS19305	COG0673	inositol 2-dehydrogenase activity
IMZ18_RS19310	COG1082	Xylose isomerase domain protein TIM barrel
IMZ18_RS19315	COG1082	Xylose isomerase domain protein TIM barrel
IMZ18_RS19320	COG0191	fructose-bisphosphate aldolase activity
IMZ18_RS19325	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS19330	COG2205	protein histidine kinase activity
IMZ18_RS19345	COG5294	Protein conserved in bacteria
IMZ18_RS19350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IMZ18_RS19380	COG0561	phosphatase activity
IMZ18_RS19385	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
IMZ18_RS19390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IMZ18_RS19395	COG0456	acetyltransferase
IMZ18_RS19400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IMZ18_RS19405	COG0765	amino acid transport
IMZ18_RS19410	COG1126	abc transporter atp-binding protein
IMZ18_RS19415	COG1473	amidohydrolase
IMZ18_RS19420	COG2079	MmgE PrpD family protein
IMZ18_RS19425	COG3192	ethanolamine utilization protein
IMZ18_RS19435	COG2390	Transcriptional regulator
IMZ18_RS19440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IMZ18_RS19445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IMZ18_RS19450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IMZ18_RS19465	COG3507	Belongs to the glycosyl hydrolase 43 family
IMZ18_RS19470	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
IMZ18_RS19475	COG0494	nUDIX hydrolase
IMZ18_RS19495	COG5444	nuclease activity
IMZ18_RS19525	COG0589	response to stress
IMZ18_RS19540	COG0697	spore germination
IMZ18_RS19655	COG3401	FG-GAP repeat protein
IMZ18_RS19655	COG2755	lipolytic protein G-D-S-L family
IMZ18_RS19660	COG0513	Belongs to the DEAD box helicase family
IMZ18_RS19665	COG2270	Major facilitator Superfamily
IMZ18_RS19675	COG3711	transcriptional antiterminator
IMZ18_RS19680	COG2273	Hydrolase Family 16
IMZ18_RS19685	COG2851	Citrate transporter
IMZ18_RS19690	COG0693	protein deglycase activity
IMZ18_RS19690	COG0753	catalase activity
IMZ18_RS19705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IMZ18_RS19710	COG0500	methyltransferase
IMZ18_RS19715	COG2610	gluconate transmembrane transporter activity
IMZ18_RS19720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IMZ18_RS19725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IMZ18_RS19730	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS19735	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IMZ18_RS19740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IMZ18_RS19745	COG4894	glucomannan catabolic process
IMZ18_RS19755	COG2195	Cleaves the N-terminal amino acid of tripeptides
IMZ18_RS19760	COG2197	response regulator
IMZ18_RS19765	COG4585	Histidine kinase
IMZ18_RS19775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IMZ18_RS19780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS19785	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS19790	COG2508	Transcriptional regulator
IMZ18_RS19795	COG3842	ATPase activity
IMZ18_RS19810	COG0726	polysaccharide deacetylase
IMZ18_RS19820	COG0501	Belongs to the peptidase M48B family
IMZ18_RS19825	COG3493	citrate carrier protein
IMZ18_RS19830	COG1271	oxidase subunit
IMZ18_RS19835	COG1294	oxidase, subunit
IMZ18_RS19840	COG4988	ABC transporter
IMZ18_RS19845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IMZ18_RS19850	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IMZ18_RS19855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IMZ18_RS19860	COG1595	DNA-templated transcription, initiation
IMZ18_RS19880	COG1131	(ABC) transporter
IMZ18_RS19885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IMZ18_RS19890	COG2814	Major facilitator Superfamily
IMZ18_RS19895	COG0753	catalase activity
IMZ18_RS19900	COG2094	Belongs to the DNA glycosylase MPG family
IMZ18_RS19910	COG3711	transcriptional antiterminator
IMZ18_RS19910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IMZ18_RS19915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IMZ18_RS19920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IMZ18_RS19925	COG1447	Phosphotransferase system cellobiose-specific component IIA
IMZ18_RS19930	COG1486	melibiose metabolic process
IMZ18_RS19935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IMZ18_RS19945	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IMZ18_RS19950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IMZ18_RS19955	COG1696	Membrane protein involved in D-alanine export
IMZ18_RS19960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IMZ18_RS19975	COG1575	Belongs to the MenA family. Type 1 subfamily
IMZ18_RS19985	COG2357	RelA SpoT domain protein
IMZ18_RS19995	COG2234	aminopeptidase activity
IMZ18_RS20000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IMZ18_RS20005	COG1846	Transcriptional regulator
IMZ18_RS20010	COG5522	Integral membrane protein (intg_mem_TP0381)
IMZ18_RS20015	COG1442	glycosyl transferase family 8
IMZ18_RS20025	COG3711	transcriptional antiterminator
IMZ18_RS20030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS20030	COG1263	PTS System
IMZ18_RS20040	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IMZ18_RS20050	COG0346	lactoylglutathione lyase activity
IMZ18_RS20055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IMZ18_RS20060	COG4895	conserved protein (DUF2196)
IMZ18_RS20065	COG2814	Major facilitator Superfamily
IMZ18_RS20070	COG1346	cytolysis
IMZ18_RS20075	COG1380	Effector of murein hydrolase LrgA
IMZ18_RS20080	COG0583	DNA-binding transcription factor activity
IMZ18_RS20085	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IMZ18_RS20090	COG0352	thiamine-phosphate diphosphorylase activity
IMZ18_RS20095	COG0672	)-iron permease
IMZ18_RS20100	COG2822	iron ion transport
IMZ18_RS20105	COG2837	iron assimilation
IMZ18_RS20110	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IMZ18_RS20120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IMZ18_RS20125	COG3162	membrane
IMZ18_RS20135	COG1309	transcriptional regulator
IMZ18_RS20140	COG2246	polysaccharide biosynthetic process
IMZ18_RS20145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IMZ18_RS20150	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IMZ18_RS20155	COG2261	transglycosylase associated protein
IMZ18_RS20160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IMZ18_RS20165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IMZ18_RS20170	COG1845	cytochrome c oxidase, subunit III
IMZ18_RS20175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IMZ18_RS20190	COG0772	Belongs to the SEDS family
IMZ18_RS20195	COG0778	Nitroreductase
IMZ18_RS20200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IMZ18_RS20205	COG1404	Belongs to the peptidase S8 family
IMZ18_RS20220	COG2116	formate transmembrane transporter activity
IMZ18_RS20225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IMZ18_RS20225	COG1263	PTS System
IMZ18_RS20230	COG1621	beta-fructofuranosidase activity
IMZ18_RS20240	COG0351	phosphomethylpyrimidine kinase
IMZ18_RS20245	COG1216	Glycosyl transferase, family 2
IMZ18_RS20250	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IMZ18_RS20255	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS20265	COG2233	PERMEase
IMZ18_RS20270	COG2363	Small membrane protein
IMZ18_RS20280	COG0463	Glycosyl transferase, family 2
IMZ18_RS20285	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IMZ18_RS20290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IMZ18_RS20295	COG0456	acetyltransferase
IMZ18_RS20300	COG2089	acid synthase
IMZ18_RS20305	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
IMZ18_RS20310	COG3980	spore coat polysaccharide biosynthesis protein
IMZ18_RS20315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IMZ18_RS20320	COG1088	dTDP-glucose 4,6-dehydratase activity
IMZ18_RS20325	COG1091	dTDP-4-dehydrorhamnose reductase activity
IMZ18_RS20330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IMZ18_RS20340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IMZ18_RS20345	COG1012	belongs to the aldehyde dehydrogenase family
IMZ18_RS20350	COG4187	Peptidase family M20/M25/M40
IMZ18_RS20355	COG0833	amino acid
IMZ18_RS20360	COG2814	Major facilitator Superfamily
IMZ18_RS20365	COG0077	Prephenate dehydratase
IMZ18_RS20370	COG1917	Cupin 2, conserved barrel domain protein
IMZ18_RS20375	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS20380	COG0151	Belongs to the GarS family
IMZ18_RS20385	COG2814	Major facilitator Superfamily
IMZ18_RS20390	COG0436	Aminotransferase
IMZ18_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
IMZ18_RS20400	COG3253	May function as heme-dependent peroxidase
IMZ18_RS20405	COG0280	phosphate acetyltransferase
IMZ18_RS20410	COG0583	DNA-binding transcription factor activity
IMZ18_RS20415	COG0095	Lipoate-protein ligase
IMZ18_RS20420	COG0697	spore germination
IMZ18_RS20430	COG4844	belongs to the
IMZ18_RS20435	COG1078	dGTPase activity
IMZ18_RS20440	COG3465	dGTPase activity
IMZ18_RS20445	COG1959	2 iron, 2 sulfur cluster binding
IMZ18_RS20450	COG0477	Major facilitator Superfamily
IMZ18_RS20460	COG1846	Transcriptional regulator
IMZ18_RS20465	COG1942	4-Oxalocrotonate Tautomerase
IMZ18_RS20470	COG1994	Peptidase M50
IMZ18_RS20485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IMZ18_RS20490	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IMZ18_RS20495	COG0010	Belongs to the arginase family
IMZ18_RS20500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IMZ18_RS20510	COG0457	Tetratricopeptide repeat
IMZ18_RS20515	COG3391	amine dehydrogenase activity
IMZ18_RS20520	COG3391	amine dehydrogenase activity
IMZ18_RS20530	COG0612	Peptidase, M16
IMZ18_RS20535	COG0612	Peptidase, M16
IMZ18_RS20540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IMZ18_RS20545	COG1131	(ABC) transporter
IMZ18_RS20555	COG0535	radical SAM domain protein
IMZ18_RS20570	COG4506	Protein conserved in bacteria
IMZ18_RS20575	COG0018	arginyl-trna synthetase
IMZ18_RS20580	COG2223	nitrite transmembrane transporter activity
IMZ18_RS20585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IMZ18_RS20595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IMZ18_RS20605	COG1140	nitrate reductase beta subunit
IMZ18_RS20610	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IMZ18_RS20615	COG2181	nitrate reductase activity
IMZ18_RS20625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IMZ18_RS20635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IMZ18_RS20645	COG4294	response to UV
IMZ18_RS20650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IMZ18_RS20655	COG2181	nitrate reductase activity
IMZ18_RS20655	COG0247	lactate metabolic process
IMZ18_RS20665	COG3343	RNA polymerase activity
IMZ18_RS20670	COG0504	CTP synthase activity
IMZ18_RS20675	COG4821	SIS domain
IMZ18_RS20680	COG2204	response regulator
IMZ18_RS20685	COG0191	fructose-bisphosphate aldolase activity
IMZ18_RS20690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IMZ18_RS20700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IMZ18_RS20705	COG1494	fructose-1,6-bisphosphatase
IMZ18_RS20715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IMZ18_RS20725	COG1435	thymidine kinase activity
IMZ18_RS20730	COG0281	malic enzyme
IMZ18_RS20735	COG0679	Auxin Efflux Carrier
IMZ18_RS20740	COG0789	Transcriptional regulator
IMZ18_RS20745	COG0346	lactoylglutathione lyase activity
IMZ18_RS20750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IMZ18_RS20755	COG2890	protein-(glutamine-N5) methyltransferase activity
IMZ18_RS20775	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IMZ18_RS20780	COG0009	L-threonylcarbamoyladenylate synthase
IMZ18_RS20785	COG1971	Probably functions as a manganese efflux pump
IMZ18_RS20790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IMZ18_RS20795	COG0698	ribose 5-phosphate isomerase
IMZ18_RS20800	COG4475	Protein of unknown function (DUF436)
IMZ18_RS20805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IMZ18_RS20810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IMZ18_RS20820	COG0356	it plays a direct role in the translocation of protons across the membrane
IMZ18_RS20830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IMZ18_RS20835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IMZ18_RS20840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IMZ18_RS20845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IMZ18_RS20850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IMZ18_RS20855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IMZ18_RS20865	COG4836	Membrane
IMZ18_RS20875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IMZ18_RS20880	COG2385	sporulation resulting in formation of a cellular spore
IMZ18_RS20885	COG2304	oxidoreductase activity
IMZ18_RS20895	COG2304	oxidoreductase activity
IMZ18_RS20905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IMZ18_RS20910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IMZ18_RS20915	COG0457	Tetratricopeptide repeat
IMZ18_RS20920	COG1994	Peptidase M50
IMZ18_RS20925	COG3237	CsbD-like
IMZ18_RS20945	COG0832	Belongs to the urease beta subunit family
IMZ18_RS20950	COG0804	urea catabolic process
IMZ18_RS20955	COG1959	2 iron, 2 sulfur cluster binding
IMZ18_RS20960	COG2910	NAD(P)H-binding
IMZ18_RS20970	COG0789	Transcriptional regulator
IMZ18_RS20975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IMZ18_RS20985	COG2089	acid synthase
IMZ18_RS20995	COG1247	-acetyltransferase
IMZ18_RS21000	COG0739	heme binding
IMZ18_RS21010	COG0671	phosphoesterase, PA-phosphatase related
IMZ18_RS21015	COG0347	Belongs to the P(II) protein family
IMZ18_RS21020	COG0004	ammonium transporteR
IMZ18_RS21030	COG1335	isochorismatase
IMZ18_RS21035	COG0477	Major facilitator Superfamily
IMZ18_RS21040	COG1953	Uracil, thiamine, allantoin
IMZ18_RS21045	COG3420	alginic acid biosynthetic process
IMZ18_RS21050	COG2814	Major facilitator Superfamily
IMZ18_RS21055	COG1846	Transcriptional regulator
IMZ18_RS21065	COG1609	Transcriptional regulator
IMZ18_RS21070	COG1077	Cell shape determining protein MreB Mrl
IMZ18_RS21075	COG4786	Flagellar basal body rod
IMZ18_RS21080	COG4786	Flagellar basal body rod
IMZ18_RS21085	COG0457	Tetratricopeptide repeat
IMZ18_RS21090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IMZ18_RS21095	COG1970	mechanosensitive ion channel activity
IMZ18_RS21100	COG2972	Histidine kinase
IMZ18_RS21100	COG0745	RESPONSE REGULATOR receiver
IMZ18_RS21110	COG3764	Sortase (surface protein transpeptidase)
IMZ18_RS21125	COG0629	single-stranded DNA binding
IMZ18_RS21130	COG1349	DNA-binding transcription factor activity
IMZ18_RS21135	COG0561	phosphatase activity
IMZ18_RS21140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IMZ18_RS21145	COG4715	Zinc finger, swim domain protein
IMZ18_RS21155	COG3944	biosynthesis protein
IMZ18_RS21160	COG0489	protein tyrosine kinase activity
IMZ18_RS21165	COG4464	protein tyrosine phosphatase activity
IMZ18_RS21170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IMZ18_RS21195	COG5444	nuclease activity
IMZ18_RS21225	COG0583	DNA-binding transcription factor activity
IMZ18_RS21230	COG0655	NAD(P)H dehydrogenase (quinone) activity
IMZ18_RS21240	COG2059	Chromate
IMZ18_RS21245	COG2059	Chromate
IMZ18_RS21250	COG1522	sequence-specific DNA binding
IMZ18_RS21255	COG0405	Gamma-glutamyltransferase
IMZ18_RS21265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IMZ18_RS21275	COG5337	Spore coat protein CotH
IMZ18_RS21290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IMZ18_RS21295	COG0583	DNA-binding transcription factor activity
IMZ18_RS21300	COG0028	Belongs to the TPP enzyme family
IMZ18_RS21305	COG3527	Alpha-acetolactate decarboxylase
IMZ18_RS21315	COG2249	NAD(P)H dehydrogenase (quinone) activity
IMZ18_RS21330	COG3103	Sh3 type 3 domain protein
IMZ18_RS21335	COG1879	ABC-type sugar transport system periplasmic component
IMZ18_RS21340	COG1172	Belongs to the binding-protein-dependent transport system permease family
IMZ18_RS21345	COG1129	ABC transporter
IMZ18_RS21350	COG1869	D-ribose catabolic process
IMZ18_RS21355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IMZ18_RS21360	COG1609	Transcriptional regulator
IMZ18_RS21365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IMZ18_RS21375	COG2843	Capsule synthesis protein
IMZ18_RS21385	COG0791	NLP P60 protein
IMZ18_RS21390	COG0561	phosphatase activity
IMZ18_RS21395	COG1316	TRANSCRIPTIONal
IMZ18_RS21410	COG0814	amino acid
IMZ18_RS21415	COG0697	spore germination
IMZ18_RS21420	COG1482	cell wall glycoprotein biosynthetic process
IMZ18_RS21425	COG4193	domain, Protein
IMZ18_RS21430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IMZ18_RS21435	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IMZ18_RS21440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IMZ18_RS21445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IMZ18_RS21450	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IMZ18_RS21450	COG0463	Glycosyl transferase, family 2
IMZ18_RS21465	COG1682	transport, permease protein
IMZ18_RS21470	COG1134	teichoic acid transport
IMZ18_RS21480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IMZ18_RS21485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IMZ18_RS21505	COG2385	sporulation resulting in formation of a cellular spore
IMZ18_RS21505	COG2247	cell wall binding repeat
IMZ18_RS21510	COG0860	N-Acetylmuramoyl-L-alanine amidase
IMZ18_RS21510	COG2247	cell wall binding repeat
IMZ18_RS21525	COG2244	polysaccharide biosynthetic process
IMZ18_RS21530	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS21530	COG0297	glycogen (starch) synthase activity
IMZ18_RS21535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IMZ18_RS21540	COG3307	-O-antigen
IMZ18_RS21545	COG3206	protein involved in exopolysaccharide biosynthesis
IMZ18_RS21550	COG1215	transferase activity, transferring glycosyl groups
IMZ18_RS21555	COG0438	transferase activity, transferring glycosyl groups
IMZ18_RS21560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IMZ18_RS21570	COG1131	(ABC) transporter
IMZ18_RS21600	COG1316	TRANSCRIPTIONal
IMZ18_RS21605	COG1739	Uncharacterized protein family UPF0029
IMZ18_RS21610	COG4585	Histidine kinase
IMZ18_RS21615	COG2197	response regulator
IMZ18_RS21620	COG1307	EDD domain protein, DegV family
IMZ18_RS21625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IMZ18_RS21635	COG1040	competence protein
IMZ18_RS21645	COG2747	anti-sigma28 factor FlgM
IMZ18_RS21650	COG3418	PFAM FlgN family protein
IMZ18_RS21655	COG4786	Flagellar basal body rod
IMZ18_RS21655	COG1256	bacterial-type flagellum assembly
IMZ18_RS21660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IMZ18_RS21670	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IMZ18_RS21675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IMZ18_RS21680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IMZ18_RS21685	COG1334	flagellar protein FlaG
IMZ18_RS21690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IMZ18_RS21695	COG1516	flagellar protein fliS
IMZ18_RS21710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IMZ18_RS21715	COG0653	protein targeting
IMZ18_RS21725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IMZ18_RS21730	COG2010	Cytochrome c
IMZ18_RS21735	COG2884	Cell division ATP-binding protein ftsE
IMZ18_RS21740	COG2177	Part of the ABC transporter FtsEX involved in
IMZ18_RS21745	COG3409	Peptidoglycan-binding domain 1 protein
IMZ18_RS21745	COG0793	Belongs to the peptidase S41A family
IMZ18_RS21755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IMZ18_RS21760	COG2814	Major facilitator Superfamily
IMZ18_RS21765	COG1309	transcriptional regulator
IMZ18_RS21770	COG3848	Pyruvate phosphate dikinase
IMZ18_RS21770	COG0574	Belongs to the PEP-utilizing enzyme family
IMZ18_RS21775	COG4897	Protein conserved in bacteria
IMZ18_RS21780	COG0556	nucleotide-excision repair
IMZ18_RS21785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IMZ18_RS21790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IMZ18_RS21805	COG3595	metallopeptidase activity
IMZ18_RS21810	COG1983	PspC domain protein
IMZ18_RS21815	COG1950	PFAM Membrane protein of
IMZ18_RS21825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IMZ18_RS21830	COG2188	Transcriptional regulator
IMZ18_RS21835	COG0363	glucosamine-6-phosphate deaminase activity
IMZ18_RS21840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IMZ18_RS21845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IMZ18_RS21850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IMZ18_RS21855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IMZ18_RS21860	COG0546	phosphoglycolate phosphatase activity
IMZ18_RS21875	COG5297	Belongs to the glycosyl hydrolase family 6
IMZ18_RS21880	COG4990	cell redox homeostasis
IMZ18_RS21885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IMZ18_RS21890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IMZ18_RS21895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IMZ18_RS21900	COG0131	Imidazoleglycerol-phosphate dehydratase
IMZ18_RS21905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IMZ18_RS21910	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IMZ18_RS21915	COG0107	imidazoleglycerol-phosphate synthase activity
IMZ18_RS21920	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IMZ18_RS21920	COG0140	phosphoribosyl-ATP diphosphatase activity
IMZ18_RS21940	COG1132	(ABC) transporter
IMZ18_RS21945	COG0457	Tetratricopeptide repeat
IMZ18_RS21950	COG3883	PFAM NLP P60 protein
IMZ18_RS21950	COG0791	NLP P60 protein
IMZ18_RS21955	COG0492	ferredoxin-NADP+ reductase activity
IMZ18_RS21960	COG1051	belongs to the nudix hydrolase family
IMZ18_RS21965	COG1660	Displays ATPase and GTPase activities
IMZ18_RS22020	COG0457	Tetratricopeptide repeat
IMZ18_RS22065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IMZ18_RS22140	COG1525	nuclease
IMZ18_RS22155	COG1793	dna ligase
IMZ18_RS22185	COG0582	viral genome integration into host DNA
IMZ18_RS22200	COG0629	single-stranded DNA binding
IMZ18_RS22260	COG3883	PFAM NLP P60 protein
IMZ18_RS22260	COG0791	NLP P60 protein