locus-tag	class	description
D9C16_RS00015	COG1595	DNA-templated transcription, initiation
D9C16_RS00020	COG1378	Sugar-specific transcriptional regulator TrmB
D9C16_RS00025	COG1280	lysine exporter protein (LysE YggA)
D9C16_RS00030	COG1113	amino acid transport
D9C16_RS00040	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D9C16_RS00040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9C16_RS00045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS00050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS00055	COG3715	PTS system
D9C16_RS00060	COG3716	PTS system mannose fructose sorbose family IID component
D9C16_RS00065	COG1621	beta-fructofuranosidase activity
D9C16_RS00070	COG0693	protein deglycase activity
D9C16_RS00075	COG1064	alcohol dehydrogenase
D9C16_RS00085	COG0789	Transcriptional regulator
D9C16_RS00090	COG5577	PFAM Coat F domain
D9C16_RS00100	COG1063	alcohol dehydrogenase
D9C16_RS00105	COG5577	PFAM Coat F domain
D9C16_RS00115	COG0346	lactoylglutathione lyase activity
D9C16_RS00125	COG4991	sh3 domain protein
D9C16_RS00130	COG4991	sh3 domain protein
D9C16_RS00140	COG5566	PFAM Mor transcription activator
D9C16_RS00145	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS00150	COG0667	Aldo Keto reductase
D9C16_RS00155	COG1595	DNA-templated transcription, initiation
D9C16_RS00160	COG3443	Belongs to the bacterial solute-binding protein 9 family
D9C16_RS00180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9C16_RS00195	COG2070	2-Nitropropane dioxygenase
D9C16_RS00205	COG2318	DinB family
D9C16_RS00220	COG1335	isochorismatase
D9C16_RS00230	COG2124	cytochrome p450
D9C16_RS00235	COG2732	(Barnase) inhibitor
D9C16_RS00240	COG1522	sequence-specific DNA binding
D9C16_RS00250	COG1687	branched-chain amino acid
D9C16_RS00255	COG1114	Component of the transport system for branched-chain amino acids
D9C16_RS00265	COG1230	cation diffusion facilitator family transporter
D9C16_RS00270	COG2072	flavoprotein involved in K transport
D9C16_RS00275	COG0583	DNA-binding transcription factor activity
D9C16_RS00280	COG0697	spore germination
D9C16_RS00290	COG1253	flavin adenine dinucleotide binding
D9C16_RS00295	COG0456	acetyltransferase
D9C16_RS00300	COG2814	Major facilitator Superfamily
D9C16_RS00305	COG4978	Transcriptional regulator
D9C16_RS00305	COG0789	Transcriptional regulator
D9C16_RS00430	COG0457	Tetratricopeptide repeat
D9C16_RS00445	COG0583	DNA-binding transcription factor activity
D9C16_RS00470	COG3209	COG3209 Rhs family protein
D9C16_RS00485	COG0398	Pfam SNARE associated Golgi protein
D9C16_RS00490	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS00490	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS00495	COG2755	lipolytic protein G-D-S-L family
D9C16_RS00505	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D9C16_RS00510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9C16_RS00515	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9C16_RS00520	COG1534	Rna-binding protein
D9C16_RS00525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9C16_RS00530	COG1713	HD superfamily hydrolase involved in NAD metabolism
D9C16_RS00535	COG0799	negative regulation of ribosome biogenesis
D9C16_RS00540	COG2226	methyltransferase
D9C16_RS00545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C16_RS00550	COG1555	photosystem II stabilization
D9C16_RS00550	COG1596	polysaccharide export
D9C16_RS00555	COG2131	deaminase
D9C16_RS00560	COG2333	competence protein COMEC
D9C16_RS00560	COG0658	competence protein
D9C16_RS00575	COG1466	dna polymerase III delta subunit
D9C16_RS00580	COG0268	Binds directly to 16S ribosomal RNA
D9C16_RS00585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D9C16_RS00590	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS00600	COG0481	GTPase activity
D9C16_RS00605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9C16_RS00610	COG1420	regulation of RNA biosynthetic process
D9C16_RS00615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9C16_RS00620	COG0443	Heat shock 70 kDa protein
D9C16_RS00625	COG0484	heat shock protein binding
D9C16_RS00630	COG2264	protein methyltransferase activity
D9C16_RS00635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9C16_RS00640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9C16_RS00645	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9C16_RS00655	COG1610	YqeY-like protein
D9C16_RS00660	COG1030	water channel activity
D9C16_RS00665	COG4864	UPF0365 protein
D9C16_RS00680	COG0561	phosphatase activity
D9C16_RS00685	COG1702	phosphate starvation-inducible protein PhoH
D9C16_RS00695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9C16_RS00700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D9C16_RS00705	COG0295	cytidine deaminase activity
D9C16_RS00710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9C16_RS00720	COG1381	Involved in DNA repair and RecF pathway recombination
D9C16_RS00725	COG0752	glycyl-tRNA synthetase alpha subunit
D9C16_RS00730	COG0751	glycine-tRNA ligase activity
D9C16_RS00735	COG0517	IMP dehydrogenase activity
D9C16_RS00740	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9C16_RS00745	COG1671	Belongs to the UPF0178 family
D9C16_RS00750	COG0358	DNA primase activity
D9C16_RS00755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9C16_RS00765	COG2010	Cytochrome c
D9C16_RS00770	COG2384	SAM-dependent methyltransferase
D9C16_RS00775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9C16_RS00780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9C16_RS00790	COG0513	Belongs to the DEAD box helicase family
D9C16_RS00795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D9C16_RS00805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS00810	COG0735	belongs to the Fur family
D9C16_RS00815	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D9C16_RS00820	COG4709	membrane
D9C16_RS00825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9C16_RS00830	COG1388	LysM domain
D9C16_RS00835	COG5521	maltodextrose utilization protein MalA
D9C16_RS00840	COG2839	Protein conserved in bacteria
D9C16_RS00845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9C16_RS00850	COG0477	Major facilitator Superfamily
D9C16_RS00855	COG0768	penicillin binding
D9C16_RS00860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9C16_RS00865	COG0573	inorganic phosphate transmembrane transporter activity
D9C16_RS00870	COG0581	inorganic phosphate transmembrane transporter activity
D9C16_RS00875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C16_RS00880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C16_RS00885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9C16_RS00900	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS00910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9C16_RS00920	COG0457	Tetratricopeptide repeat
D9C16_RS00920	COG0705	Rhomboid family
D9C16_RS00925	COG4483	Protein conserved in bacteria
D9C16_RS00930	COG1940	carbohydrate kinase activity
D9C16_RS00935	COG1368	sulfuric ester hydrolase activity
D9C16_RS00940	COG2866	Carboxypeptidase
D9C16_RS00950	COG0011	TIGRFAM Protein of
D9C16_RS00960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS00970	COG1393	Belongs to the ArsC family
D9C16_RS00980	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS00985	COG1253	flavin adenine dinucleotide binding
D9C16_RS00990	COG0598	Magnesium transport protein CorA
D9C16_RS00995	COG0517	IMP dehydrogenase activity
D9C16_RS01000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9C16_RS01005	COG1459	type II secretion system
D9C16_RS01010	COG4537	Required for transformation and DNA binding
D9C16_RS01015	COG4970	Tfp pilus assembly protein FimT
D9C16_RS01025	COG4940	Competence protein ComGF
D9C16_RS01050	COG0681	Belongs to the peptidase S26 family
D9C16_RS01060	COG1396	sequence-specific DNA binding
D9C16_RS01075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9C16_RS01080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9C16_RS01085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9C16_RS01090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9C16_RS01095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9C16_RS01100	COG0095	Lipoate-protein ligase
D9C16_RS01105	COG1321	iron dependent repressor
D9C16_RS01110	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9C16_RS01120	COG3872	metal-dependent enzyme
D9C16_RS01130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9C16_RS01135	COG0006	proline dipeptidase activity
D9C16_RS01140	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9C16_RS01150	COG3854	ATPases associated with a variety of cellular activities
D9C16_RS01195	COG0511	ligase activity, forming carbon-carbon bonds
D9C16_RS01200	COG0439	Biotin carboxylase
D9C16_RS01205	COG1302	Protein conserved in bacteria
D9C16_RS01210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9C16_RS01215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9C16_RS01220	COG1570	exodeoxyribonuclease VII activity
D9C16_RS01225	COG1722	exodeoxyribonuclease VII activity
D9C16_RS01230	COG0142	geranyltranstransferase activity
D9C16_RS01235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9C16_RS01240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D9C16_RS01245	COG1438	arginine binding
D9C16_RS01250	COG0497	DNA recombination
D9C16_RS01255	COG0750	zinc metalloprotease
D9C16_RS01265	COG0745	RESPONSE REGULATOR receiver
D9C16_RS01270	COG1902	pentaerythritol trinitrate reductase activity
D9C16_RS01285	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS01290	COG0584	glycerophosphoryl diester phosphodiesterase
D9C16_RS01295	COG0183	Belongs to the thiolase family
D9C16_RS01300	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9C16_RS01305	COG1960	acyl-CoA dehydrogenase activity
D9C16_RS01310	COG0372	Belongs to the citrate synthase family
D9C16_RS01315	COG2079	MmgE PrpD family protein
D9C16_RS01320	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9C16_RS01330	COG3290	protein histidine kinase activity
D9C16_RS01330	COG3829	transcription factor binding
D9C16_RS01335	COG0280	phosphate acetyltransferase
D9C16_RS01340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C16_RS01345	COG3426	butyrate kinase activity
D9C16_RS01350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C16_RS01355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C16_RS01360	COG0022	dehydrogenase e1 component
D9C16_RS01365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C16_RS01370	COG0789	Transcriptional regulator
D9C16_RS01370	COG4978	Transcriptional regulator
D9C16_RS01380	COG1597	lipid kinase activity
D9C16_RS01390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C16_RS01395	COG0765	amino acid transport
D9C16_RS01400	COG1126	abc transporter atp-binding protein
D9C16_RS01405	COG4129	membrane
D9C16_RS01410	COG1376	ErfK ybiS ycfS ynhG family protein
D9C16_RS01415	COG0346	lactoylglutathione lyase activity
D9C16_RS01425	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9C16_RS01430	COG3361	conserved protein (COG2071)
D9C16_RS01435	COG0706	membrane insertase activity
D9C16_RS01445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9C16_RS01450	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9C16_RS01455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9C16_RS01460	COG1234	tRNA 3'-trailer cleavage
D9C16_RS01470	COG0596	Alpha beta hydrolase
D9C16_RS01485	COG1902	pentaerythritol trinitrate reductase activity
D9C16_RS01490	COG4187	Peptidase family M20/M25/M40
D9C16_RS01495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C16_RS01500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS01505	COG0300	oxidoreductase activity
D9C16_RS01510	COG3048	D-serine ammonia-lyase activity
D9C16_RS01515	COG1072	(Pantothenic acid kinase))
D9C16_RS01520	COG0346	lactoylglutathione lyase activity
D9C16_RS01525	COG2211	Major facilitator Superfamily
D9C16_RS01535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9C16_RS01545	COG0456	acetyltransferase
D9C16_RS01550	COG2329	Antibiotic biosynthesis monooxygenase
D9C16_RS01555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D9C16_RS01555	COG0456	acetyltransferase
D9C16_RS01560	COG4918	Iron-sulphur cluster biosynthesis
D9C16_RS01570	COG1073	alpha beta
D9C16_RS01580	COG0667	Aldo Keto reductase
D9C16_RS01590	COG0494	nUDIX hydrolase
D9C16_RS01595	COG1379	DNA repair
D9C16_RS01600	COG1396	sequence-specific DNA binding
D9C16_RS01605	COG0252	asparaginase activity
D9C16_RS01610	COG1027	Aspartate ammonia-lyase
D9C16_RS01615	COG1757	Na H antiporter
D9C16_RS01620	COG0281	malic enzyme
D9C16_RS01630	COG1300	Membrane
D9C16_RS01635	COG0735	belongs to the Fur family
D9C16_RS01645	COG4974	Belongs to the 'phage' integrase family
D9C16_RS01650	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D9C16_RS01655	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9C16_RS01660	COG1686	Belongs to the peptidase S11 family
D9C16_RS01665	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS01670	COG2172	sigma factor antagonist activity
D9C16_RS01675	COG1191	sigma factor activity
D9C16_RS01695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9C16_RS01710	COG0697	spore germination
D9C16_RS01715	COG0019	diaminopimelate decarboxylase activity
D9C16_RS01720	COG4086	secreted protein
D9C16_RS01735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9C16_RS01790	COG3328	transposase activity
D9C16_RS01840	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D9C16_RS01850	COG0681	Belongs to the peptidase S26 family
D9C16_RS01860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9C16_RS01860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9C16_RS01865	COG0307	riboflavin synthase, alpha
D9C16_RS01870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9C16_RS01870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9C16_RS01875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9C16_RS01880	COG0456	acetyltransferase
D9C16_RS01885	COG1547	Domain of unknown function (DUF309)
D9C16_RS01890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D9C16_RS01895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9C16_RS01905	COG1686	Belongs to the peptidase S11 family
D9C16_RS01910	COG2715	membrane protein required for spore maturation
D9C16_RS01915	COG0700	Nucleoside recognition
D9C16_RS01920	COG1187	pseudouridine synthase activity
D9C16_RS01925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS01930	COG1333	cytochrome c biogenesis protein
D9C16_RS01935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9C16_RS01940	COG0745	RESPONSE REGULATOR receiver
D9C16_RS01945	COG5002	protein histidine kinase activity
D9C16_RS01950	COG1595	DNA-templated transcription, initiation
D9C16_RS01960	COG0710	3-dehydroquinate dehydratase activity
D9C16_RS01965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9C16_RS01970	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D9C16_RS01975	COG1141	Ferredoxin
D9C16_RS01980	COG4955	Helix-turn-helix domain
D9C16_RS01985	COG0514	ATP-dependent DNA helicase (RecQ)
D9C16_RS01990	COG1266	CAAX protease self-immunity
D9C16_RS01995	COG1388	LysM domain
D9C16_RS02010	COG4862	establishment of competence for transformation
D9C16_RS02015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C16_RS02020	COG0492	ferredoxin-NADP+ reductase activity
D9C16_RS02025	COG2339	peptidase activity
D9C16_RS02030	COG3773	Cell wall hydrolase
D9C16_RS02030	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS02035	COG2959	enzyme of heme biosynthesis
D9C16_RS02040	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D9C16_RS02050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9C16_RS02055	COG0539	negative regulation of cytoplasmic translation
D9C16_RS02060	COG1304	FMN binding
D9C16_RS02085	COG1160	GTP binding
D9C16_RS02090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9C16_RS02105	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9C16_RS02110	COG0776	regulation of translation
D9C16_RS02115	COG0302	gtp cyclohydrolase
D9C16_RS02125	COG0142	geranyltranstransferase activity
D9C16_RS02130	COG2226	methyltransferase
D9C16_RS02135	COG0142	geranyltranstransferase activity
D9C16_RS02140	COG0105	UTP biosynthetic process
D9C16_RS02145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9C16_RS02150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9C16_RS02155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9C16_RS02160	COG4401	Chorismate mutase type I
D9C16_RS02165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9C16_RS02180	COG0135	phosphoribosylanthranilate isomerase activity
D9C16_RS02185	COG0133	tryptophan synthase activity
D9C16_RS02200	COG0287	Prephenate dehydrogenase
D9C16_RS02205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9C16_RS02210	COG0457	Tetratricopeptide repeat
D9C16_RS02215	COG5582	Belongs to the UPF0302 family
D9C16_RS02225	COG0723	plastoquinol--plastocyanin reductase activity
D9C16_RS02230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9C16_RS02235	COG2010	Cytochrome c
D9C16_RS02235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9C16_RS02240	COG4347	Protein of unknown function (DUF1405)
D9C16_RS02250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS02255	COG1694	Mazg nucleotide pyrophosphohydrolase
D9C16_RS02260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9C16_RS02265	COG1803	Methylglyoxal synthase
D9C16_RS02270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C16_RS02275	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS02280	COG0617	tRNA 3'-terminal CCA addition
D9C16_RS02285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D9C16_RS02285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D9C16_RS02290	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9C16_RS02295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9C16_RS02300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9C16_RS02305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9C16_RS02305	COG1199	ATP-dependent helicase activity
D9C16_RS02315	COG5353	protein conserved in bacteria
D9C16_RS02320	COG0436	Aminotransferase
D9C16_RS02325	COG0017	Asparaginyl-tRNA synthetase
D9C16_RS02330	COG3935	DnaD domain protein
D9C16_RS02335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9C16_RS02345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C16_RS02345	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9C16_RS02385	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C16_RS02390	COG2190	(PTS) system
D9C16_RS02395	COG1205	dead DEAH box helicase
D9C16_RS02395	COG1111	helicase
D9C16_RS02400	COG3359	exonuclease
D9C16_RS02415	COG4474	Belongs to the UPF0398 family
D9C16_RS02430	COG0116	Belongs to the methyltransferase superfamily
D9C16_RS02445	COG1199	ATP-dependent helicase activity
D9C16_RS02450	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS02455	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D9C16_RS02460	COG1609	Transcriptional regulator
D9C16_RS02465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C16_RS02470	COG0800	Aldolase
D9C16_RS02480	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D9C16_RS02485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C16_RS02490	COG2233	PERMEase
D9C16_RS02495	COG3424	synthase
D9C16_RS02500	COG1755	Isoprenylcysteine carboxyl methyltransferase
D9C16_RS02510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9C16_RS02525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C16_RS02535	COG0328	RNA-DNA hybrid ribonuclease activity
D9C16_RS02540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D9C16_RS02545	COG0328	RNA-DNA hybrid ribonuclease activity
D9C16_RS02565	COG1278	Cold shock
D9C16_RS02575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C16_RS02580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9C16_RS02585	COG0386	Belongs to the glutathione peroxidase family
D9C16_RS02590	COG1418	mRNA catabolic process
D9C16_RS02595	COG1413	lyase activity
D9C16_RS02600	COG0129	dihydroxy-acid dehydratase activity
D9C16_RS02610	COG2136	Putative SAM-dependent methyltransferase
D9C16_RS02610	COG2521	methyltransferase
D9C16_RS02620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9C16_RS02625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C16_RS02630	COG0204	Acyl-transferase
D9C16_RS02635	COG1272	protein, Hemolysin III
D9C16_RS02640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9C16_RS02645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9C16_RS02655	COG1999	signal sequence binding
D9C16_RS02660	COG2755	lipolytic protein G-D-S-L family
D9C16_RS02665	COG4698	Protein conserved in bacteria
D9C16_RS02675	COG0534	Mate efflux family protein
D9C16_RS02680	COG1846	Transcriptional regulator
D9C16_RS02685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9C16_RS02690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9C16_RS02695	COG1086	Polysaccharide biosynthesis protein
D9C16_RS02700	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D9C16_RS02705	COG4641	Protein conserved in bacteria
D9C16_RS02720	COG0463	Glycosyl transferase, family 2
D9C16_RS02725	COG0456	acetyltransferase
D9C16_RS02740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C16_RS02750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9C16_RS02755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C16_RS02760	COG0456	acetyltransferase
D9C16_RS02765	COG1509	lysine 2,3-aminomutase activity
D9C16_RS02775	COG4479	Belongs to the UPF0346 family
D9C16_RS02800	COG0671	phosphoesterase, PA-phosphatase related
D9C16_RS02815	COG0813	purine-nucleoside phosphorylase activity
D9C16_RS02820	COG1876	peptidase activity
D9C16_RS02830	COG2226	methyltransferase
D9C16_RS02835	COG0793	Belongs to the peptidase S41A family
D9C16_RS02835	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS02840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C16_RS02855	COG0400	carboxylic ester hydrolase activity
D9C16_RS02865	COG0778	Nitroreductase
D9C16_RS02870	COG1733	regulation of RNA biosynthetic process
D9C16_RS02875	COG1942	4-Oxalocrotonate Tautomerase
D9C16_RS02895	COG2962	Rard protein
D9C16_RS02905	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C16_RS02910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C16_RS02915	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS02920	COG0534	Mate efflux family protein
D9C16_RS02925	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9C16_RS02930	COG1819	glycosyl
D9C16_RS02935	COG1388	LysM domain
D9C16_RS02935	COG0791	NLP P60 protein
D9C16_RS02940	COG2032	superoxide dismutase activity
D9C16_RS02945	COG0714	Associated with various cellular activities
D9C16_RS02950	COG4548	von Willebrand factor, type A
D9C16_RS02955	COG0567	Dehydrogenase, E1 component
D9C16_RS02960	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C16_RS02965	COG0385	Bile acid
D9C16_RS02970	COG0733	neurotransmitter:sodium symporter activity
D9C16_RS02975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9C16_RS02980	COG1657	PFAM Prenyltransferase squalene oxidase
D9C16_RS02985	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS03010	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C16_RS03025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C16_RS03030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9C16_RS03045	COG0514	ATP-dependent DNA helicase (RecQ)
D9C16_RS03050	COG3584	3D domain protein
D9C16_RS03050	COG1388	LysM domain
D9C16_RS03055	COG2197	response regulator
D9C16_RS03060	COG4585	Histidine kinase
D9C16_RS03065	COG3239	Fatty acid desaturase
D9C16_RS03070	COG1619	proteins homologs of microcin C7 resistance protein MccF
D9C16_RS03085	COG2322	membrane
D9C16_RS03090	COG0741	lytic transglycosylase activity
D9C16_RS03095	COG0640	Transcriptional regulator
D9C16_RS03105	COG2378	regulation of single-species biofilm formation
D9C16_RS03110	COG3708	Transcriptional regulator
D9C16_RS03115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS03120	COG1309	transcriptional regulator
D9C16_RS03125	COG0456	acetyltransferase
D9C16_RS03130	COG2207	Transcriptional regulator
D9C16_RS03130	COG0662	Cupin 2, conserved barrel domain protein
D9C16_RS03135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C16_RS03140	COG1231	oxidoreductase activity
D9C16_RS03145	COG4282	regulation of fungal-type cell wall biogenesis
D9C16_RS03150	COG5444	nuclease activity
D9C16_RS03170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS03200	COG3328	transposase activity
D9C16_RS03210	COG2814	Major facilitator Superfamily
D9C16_RS03220	COG1131	(ABC) transporter
D9C16_RS03235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS03245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D9C16_RS03250	COG0300	oxidoreductase activity
D9C16_RS03280	COG0583	DNA-binding transcription factor activity
D9C16_RS03285	COG0070	glutamate synthase
D9C16_RS03285	COG0069	glutamate synthase activity
D9C16_RS03285	COG0067	glutamate synthase
D9C16_RS03290	COG0493	'glutamate synthase
D9C16_RS03295	COG0604	alcohol dehydrogenase
D9C16_RS03300	COG0583	DNA-binding transcription factor activity
D9C16_RS03305	COG0405	Gamma-glutamyltransferase
D9C16_RS03310	COG0166	Belongs to the GPI family
D9C16_RS03315	COG0582	viral genome integration into host DNA
D9C16_RS03335	COG0534	Mate efflux family protein
D9C16_RS03340	COG2017	converts alpha-aldose to the beta-anomer
D9C16_RS03345	COG2027	D-alanyl-D-alanine carboxypeptidase
D9C16_RS03350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS03365	COG1649	PFAM Uncharacterised BCR, COG1649
D9C16_RS03375	COG1960	acyl-CoA dehydrogenase activity
D9C16_RS03380	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS03385	COG0439	Biotin carboxylase
D9C16_RS03390	COG0511	ligase activity, forming carbon-carbon bonds
D9C16_RS03395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9C16_RS03400	COG1024	Enoyl-CoA hydratase
D9C16_RS03405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9C16_RS03410	COG2404	hydrolase activity, acting on ester bonds
D9C16_RS03415	COG0586	Pfam SNARE associated Golgi protein
D9C16_RS03420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C16_RS03425	COG2246	polysaccharide biosynthetic process
D9C16_RS03445	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9C16_RS03450	COG1115	amino acid carrier protein
D9C16_RS03460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9C16_RS03465	COG0187	DNA topoisomerase II activity
D9C16_RS03470	COG1832	CoA-binding protein
D9C16_RS03475	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9C16_RS03480	COG4841	protein insertion into membrane
D9C16_RS03490	COG0824	Thioesterase
D9C16_RS03510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS03515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9C16_RS03530	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C16_RS03540	COG4846	Membrane protein involved in cytochrome C biogenesis
D9C16_RS03545	COG2201	protein-glutamate methylesterase activity
D9C16_RS03550	COG0785	Cytochrome C biogenesis protein
D9C16_RS03560	COG3763	UPF0154 protein
D9C16_RS03570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9C16_RS03575	COG4224	UPF0291 protein
D9C16_RS03580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9C16_RS03585	COG1388	LysM domain
D9C16_RS03590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9C16_RS03600	COG0346	lactoylglutathione lyase activity
D9C16_RS03610	COG4195	phage-related replication protein
D9C16_RS03655	COG3832	glyoxalase III activity
D9C16_RS03670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C16_RS03715	COG0756	dUTP diphosphatase activity
D9C16_RS03730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9C16_RS03735	COG2814	Major facilitator Superfamily
D9C16_RS03740	COG1525	nuclease
D9C16_RS03745	COG3328	transposase activity
D9C16_RS03770	COG1070	Carbohydrate kinase
D9C16_RS03775	COG2115	Belongs to the xylose isomerase family
D9C16_RS03780	COG1940	carbohydrate kinase activity
D9C16_RS03785	COG3507	Belongs to the glycosyl hydrolase 43 family
D9C16_RS03800	COG2211	Major facilitator Superfamily
D9C16_RS03805	COG0135	phosphoribosylanthranilate isomerase activity
D9C16_RS03830	COG3655	Transcriptional regulator
D9C16_RS03845	COG3328	transposase activity
D9C16_RS03870	COG4282	regulation of fungal-type cell wall biogenesis
D9C16_RS03910	COG5444	nuclease activity
D9C16_RS03920	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS03920	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS03920	COG1388	LysM domain
D9C16_RS03965	COG3953	SLT domain
D9C16_RS03965	COG5412	phage tail tape measure protein
D9C16_RS04110	COG3646	Phage regulatory protein
D9C16_RS04110	COG3645	SOS response
D9C16_RS04130	COG4974	Belongs to the 'phage' integrase family
D9C16_RS04135	COG0174	glutamine synthetase
D9C16_RS04140	COG0789	Transcriptional regulator
D9C16_RS04145	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D9C16_RS04150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9C16_RS04155	COG0464	growth
D9C16_RS04165	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS04170	COG4112	unkown
D9C16_RS04175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9C16_RS04180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9C16_RS04185	COG1780	Probably involved in ribonucleotide reductase function
D9C16_RS04200	COG1923	regulation of RNA biosynthetic process
D9C16_RS04205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9C16_RS04220	COG2076	Multidrug Resistance protein
D9C16_RS04225	COG2076	Multidrug Resistance protein
D9C16_RS04230	COG1764	response to oxidative stress
D9C16_RS04235	COG4195	phage-related replication protein
D9C16_RS04245	COG1404	Belongs to the peptidase S8 family
D9C16_RS04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS04260	COG3226	Transcriptional regulator
D9C16_RS04280	COG3328	transposase activity
D9C16_RS04355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9C16_RS04360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9C16_RS04370	COG4550	Control of competence regulator ComK, YlbF/YmcA
D9C16_RS04375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9C16_RS04380	COG0156	8-amino-7-oxononanoate synthase activity
D9C16_RS04385	COG1063	alcohol dehydrogenase
D9C16_RS04390	COG2359	stage V sporulation protein S
D9C16_RS04395	COG1692	metallophosphoesterase
D9C16_RS04400	COG1418	mRNA catabolic process
D9C16_RS04405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9C16_RS04410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D9C16_RS04415	COG1058	Belongs to the CinA family
D9C16_RS04415	COG1546	Belongs to the CinA family
D9C16_RS04420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9C16_RS04425	COG1426	Protein conserved in bacteria
D9C16_RS04440	COG0300	oxidoreductase activity
D9C16_RS04445	COG0612	Peptidase, M16
D9C16_RS04450	COG0612	Peptidase, M16
D9C16_RS04455	COG2814	Major facilitator Superfamily
D9C16_RS04460	COG2188	Transcriptional regulator
D9C16_RS04465	COG1674	ftsk spoiiie
D9C16_RS04465	COG4980	gas vesicle protein
D9C16_RS04475	COG0740	serine-type endopeptidase activity
D9C16_RS04480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9C16_RS04485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9C16_RS04490	COG0527	aspartate kinase activity
D9C16_RS04495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9C16_RS04500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9C16_RS04505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9C16_RS04510	COG1873	PFAM PRC-barrel domain
D9C16_RS04515	COG0612	Peptidase, M16
D9C16_RS04520	COG0726	polysaccharide deacetylase
D9C16_RS04525	COG1185	polyribonucleotide nucleotidyltransferase activity
D9C16_RS04530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9C16_RS04535	COG0196	riboflavin kinase activity
D9C16_RS04540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9C16_RS04545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9C16_RS04550	COG1550	Protein conserved in bacteria
D9C16_RS04555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9C16_RS04560	COG1358	cellular component organization or biogenesis
D9C16_RS04565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D9C16_RS04570	COG0195	Participates in both transcription termination and antitermination
D9C16_RS04575	COG0779	Required for maturation of 30S ribosomal subunits
D9C16_RS04580	COG2176	DNA-directed DNA polymerase activity
D9C16_RS04585	COG0442	prolyl-tRNA aminoacylation
D9C16_RS04590	COG0750	zinc metalloprotease
D9C16_RS04595	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9C16_RS04600	COG4589	Belongs to the CDS family
D9C16_RS04605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9C16_RS04610	COG0233	cytoplasmic translational termination
D9C16_RS04615	COG0528	UMP kinase activity
D9C16_RS04620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9C16_RS04625	COG0052	Belongs to the universal ribosomal protein uS2 family
D9C16_RS04635	COG1191	sigma factor activity
D9C16_RS04640	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9C16_RS04650	COG0835	chemotaxis
D9C16_RS04655	COG0643	Histidine kinase
D9C16_RS04655	COG2198	Histidine kinase
D9C16_RS04660	COG2201	protein-glutamate methylesterase activity
D9C16_RS04665	COG0455	bacterial-type flagellum organization
D9C16_RS04670	COG1419	protein localization to endoplasmic reticulum
D9C16_RS04675	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9C16_RS04680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9C16_RS04685	COG1684	flagellar biosynthetic protein fliR
D9C16_RS04690	COG1987	bacterial-type flagellum assembly
D9C16_RS04695	COG1338	Plays a role in the flagellum-specific transport system
D9C16_RS04700	COG3190	flagellar
D9C16_RS04705	COG2201	protein-glutamate methylesterase activity
D9C16_RS04710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C16_RS04710	COG1776	CheC inhibitor of MCP methylation
D9C16_RS04715	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C16_RS04720	COG1580	Controls the rotational direction of flagella during chemotaxis
D9C16_RS04725	COG1582	Flagellar protein (FlbD)
D9C16_RS04730	COG4786	Flagellar basal body rod
D9C16_RS04735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9C16_RS04740	COG3144	bacterial-type flagellum assembly
D9C16_RS04745	COG3334	PFAM MgtE intracellular
D9C16_RS04750	COG2882	bacterial-type flagellum organization
D9C16_RS04755	COG1157	protein secretion by the type III secretion system
D9C16_RS04760	COG1317	bacterial-type flagellum organization
D9C16_RS04765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C16_RS04775	COG1677	Flagellar hook-basal body complex protein FliE
D9C16_RS04780	COG1558	bacterial-type flagellum-dependent cell motility
D9C16_RS04785	COG1815	bacterial-type flagellum-dependent cell motility
D9C16_RS04790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9C16_RS04795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9C16_RS04800	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9C16_RS04805	COG4974	Belongs to the 'phage' integrase family
D9C16_RS04810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D9C16_RS04815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9C16_RS04820	COG0758	DNA mediated transformation
D9C16_RS04825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9C16_RS04830	COG0045	succinate-CoA ligase (ADP-forming) activity
D9C16_RS04835	COG2257	FlhB HrpN YscU SpaS Family
D9C16_RS04845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9C16_RS04850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9C16_RS04855	COG0335	large ribosomal subunit rRNA binding
D9C16_RS04860	COG0336	Belongs to the RNA methyltransferase TrmD family
D9C16_RS04865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9C16_RS04875	COG1837	Belongs to the UPF0109 family
D9C16_RS04880	COG0228	four-way junction DNA binding
D9C16_RS04885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9C16_RS04890	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D9C16_RS04900	COG0552	protein localization to endoplasmic reticulum
D9C16_RS04905	COG1196	nuclear chromosome segregation
D9C16_RS04910	COG0571	ribonuclease III activity
D9C16_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS04925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9C16_RS04930	COG0416	fatty acid biosynthetic process
D9C16_RS04935	COG2050	protein possibly involved in aromatic compounds catabolism
D9C16_RS04935	COG1349	DNA-binding transcription factor activity
D9C16_RS04940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9C16_RS04945	COG1760	l-serine dehydratase
D9C16_RS04950	COG1760	l-serine dehydratase
D9C16_RS04955	COG1461	Dihydroxyacetone kinase
D9C16_RS04960	COG1302	Protein conserved in bacteria
D9C16_RS04965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9C16_RS04975	COG1564	THIamine pyrophosphokinase
D9C16_RS04980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9C16_RS04985	COG1162	GTPase activity
D9C16_RS04990	COG2815	serine threonine protein kinase
D9C16_RS04990	COG0515	serine threonine protein kinase
D9C16_RS04995	COG0631	protein serine/threonine phosphatase activity
D9C16_RS05000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9C16_RS05005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9C16_RS05005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9C16_RS05010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9C16_RS05015	COG0242	peptide deformylase activity
D9C16_RS05020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9C16_RS05025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9C16_RS05030	COG1758	RNA polymerase activity
D9C16_RS05035	COG0194	GDP metabolic process
D9C16_RS05045	COG1561	YicC-like family, N-terminal region
D9C16_RS05050	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9C16_RS05060	COG1648	precorrin-2 dehydrogenase activity
D9C16_RS05065	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D9C16_RS05070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9C16_RS05075	COG0529	Catalyzes the synthesis of activated sulfate
D9C16_RS05080	COG2046	Belongs to the sulfate adenylyltransferase family
D9C16_RS05085	COG0306	phosphate transporter
D9C16_RS05090	COG0175	sulfate reduction
D9C16_RS05095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9C16_RS05100	COG0284	orotidine-5'-phosphate decarboxylase activity
D9C16_RS05105	COG0167	dihydroorotate dehydrogenase activity
D9C16_RS05110	COG0543	2 iron, 2 sulfur cluster binding
D9C16_RS05115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9C16_RS05120	COG0505	Belongs to the CarA family
D9C16_RS05125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9C16_RS05130	COG0540	Belongs to the ATCase OTCase family
D9C16_RS05135	COG2233	PERMEase
D9C16_RS05140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D9C16_RS05145	COG0564	pseudouridine synthase activity
D9C16_RS05150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9C16_RS05155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C16_RS05160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9C16_RS05165	COG3599	regulation of cell shape
D9C16_RS05170	COG2302	S4 RNA-binding domain
D9C16_RS05175	COG0762	integral membrane protein
D9C16_RS05180	COG1799	cell septum assembly
D9C16_RS05185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D9C16_RS05190	COG1496	oxidoreductase activity
D9C16_RS05195	COG1873	PFAM PRC-barrel domain
D9C16_RS05200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C16_RS05205	COG1119	ATPase activity
D9C16_RS05210	COG1191	sigma factor activity
D9C16_RS05215	COG1191	sigma factor activity
D9C16_RS05225	COG1404	Belongs to the peptidase S8 family
D9C16_RS05225	COG4412	M6 family metalloprotease domain protein
D9C16_RS05230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9C16_RS05235	COG0849	cell division
D9C16_RS05240	COG3856	small basic protein
D9C16_RS05245	COG3879	Bacterial protein of unknown function (DUF881)
D9C16_RS05250	COG3879	Bacterial protein of unknown function (DUF881)
D9C16_RS05255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9C16_RS05260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9C16_RS05265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C16_RS05270	COG0772	Belongs to the SEDS family
D9C16_RS05275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9C16_RS05280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9C16_RS05285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9C16_RS05290	COG0768	penicillin binding
D9C16_RS05295	COG0768	penicillin binding
D9C16_RS05300	COG4839	cell division protein FtsL
D9C16_RS05305	COG0275	rRNA processing
D9C16_RS05310	COG2001	Belongs to the MraZ family
D9C16_RS05315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D9C16_RS05320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9C16_RS05325	COG0454	-acetyltransferase
D9C16_RS05340	COG1399	metal-binding, possibly nucleic acid-binding protein
D9C16_RS05350	COG1323	Belongs to the UPF0348 family
D9C16_RS05355	COG3480	Lon protease (S16) C-terminal proteolytic domain
D9C16_RS05360	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9C16_RS05365	COG3314	Sporulation integral membrane protein YlbJ
D9C16_RS05370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9C16_RS05375	COG0742	ribosomal rna small subunit methyltransferase
D9C16_RS05380	COG4471	UPF0298 protein
D9C16_RS05385	COG3679	Belongs to the UPF0342 family
D9C16_RS05400	COG2340	Cysteine-rich secretory protein family
D9C16_RS05405	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D9C16_RS05415	COG3336	cytochrome c oxidase
D9C16_RS05420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9C16_RS05425	COG1845	cytochrome c oxidase, subunit III
D9C16_RS05430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9C16_RS05435	COG2010	Cytochrome c
D9C16_RS05435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9C16_RS05440	COG0109	protoheme IX farnesyltransferase activity
D9C16_RS05445	COG1612	heme a metabolic process
D9C16_RS05450	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D9C16_RS05455	COG0772	Belongs to the SEDS family
D9C16_RS05460	COG4838	Belongs to the UPF0358 family
D9C16_RS05465	COG2066	Belongs to the glutaminase family
D9C16_RS05470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9C16_RS05475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9C16_RS05485	COG4896	Protein conserved in bacteria
D9C16_RS05495	COG1217	gtp-binding protein TYPA
D9C16_RS05540	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D9C16_RS05555	COG0483	inositol monophosphate 1-phosphatase activity
D9C16_RS05565	COG4493	Belongs to the UPF0637 family
D9C16_RS05570	COG4476	Belongs to the UPF0223 family
D9C16_RS05575	COG1982	Orn Lys Arg decarboxylase major
D9C16_RS05585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS05590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C16_RS05595	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C16_RS05600	COG0022	dehydrogenase e1 component
D9C16_RS05605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C16_RS05620	COG0242	peptide deformylase activity
D9C16_RS05625	COG0561	phosphatase activity
D9C16_RS05630	COG5503	Protein of unknown function (DUF1447)
D9C16_RS05635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9C16_RS05640	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9C16_RS05645	COG0569	domain protein
D9C16_RS05650	COG2105	PFAM AIG2 family protein
D9C16_RS05650	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D9C16_RS05655	COG3852	Histidine kinase
D9C16_RS05660	COG2002	toxin-antitoxin pair type II binding
D9C16_RS05665	COG1077	Cell shape determining protein MreB Mrl
D9C16_RS05675	COG2309	aminopeptidase activity
D9C16_RS05680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9C16_RS05685	COG0488	(ABC) transporter
D9C16_RS05695	COG0681	Belongs to the peptidase S26 family
D9C16_RS05700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C16_RS05700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C16_RS05700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS05705	COG1105	Belongs to the carbohydrate kinase PfkB family
D9C16_RS05710	COG1349	DNA-binding transcription factor activity
D9C16_RS05715	COG0577	efflux transmembrane transporter activity
D9C16_RS05720	COG1136	(ABC) transporter
D9C16_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9C16_RS05735	COG1132	(ABC) transporter
D9C16_RS05745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9C16_RS05750	COG0314	molybdopterin synthase activity
D9C16_RS05755	COG1763	Mo-molybdopterin cofactor biosynthetic process
D9C16_RS05760	COG0303	'Molybdopterin
D9C16_RS05765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C16_RS05770	COG0746	molybdenum cofactor guanylyltransferase activity
D9C16_RS05790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS05795	COG0450	alkyl hydroperoxide reductase
D9C16_RS05800	COG0668	transmembrane transport
D9C16_RS05810	COG1473	amidohydrolase
D9C16_RS05815	COG2171	N-acyltransferase activity
D9C16_RS05820	COG0716	FMN binding
D9C16_RS05830	COG0716	FMN binding
D9C16_RS05835	COG0583	DNA-binding transcription factor activity
D9C16_RS05840	COG0517	IMP dehydrogenase activity
D9C16_RS05850	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D9C16_RS05855	COG4703	Protein of unknown function (DUF1797)
D9C16_RS05860	COG2200	EAL domain
D9C16_RS05865	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS05870	COG1408	metallophosphoesterase
D9C16_RS05875	COG1376	ErfK ybiS ycfS ynhG family protein
D9C16_RS05880	COG2814	Major facilitator Superfamily
D9C16_RS05890	COG0784	Response regulator, receiver
D9C16_RS05890	COG0835	chemotaxis
D9C16_RS05900	COG0436	Aminotransferase
D9C16_RS05905	COG4191	Histidine kinase
D9C16_RS05910	COG0768	penicillin binding
D9C16_RS05915	COG2340	Cysteine-rich secretory protein family
D9C16_RS05925	COG3328	transposase activity
D9C16_RS05930	COG2084	Dehydrogenase
D9C16_RS05935	COG0840	transmembrane signaling receptor activity
D9C16_RS05940	COG0456	acetyltransferase
D9C16_RS05945	COG1533	DNA photolyase activity
D9C16_RS05955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9C16_RS05960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS05965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS05965	COG2190	(PTS) system
D9C16_RS05965	COG1263	PTS System
D9C16_RS05970	COG3711	transcriptional antiterminator
D9C16_RS05975	COG1609	Transcriptional regulator
D9C16_RS05980	COG0006	proline dipeptidase activity
D9C16_RS05990	COG2217	Heavy metal translocating P-type atpase
D9C16_RS05995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS06000	COG2244	polysaccharide biosynthetic process
D9C16_RS06005	COG3773	Cell wall hydrolase
D9C16_RS06015	COG4873	Protein conserved in bacteria
D9C16_RS06025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9C16_RS06030	COG0602	queuosine metabolic process
D9C16_RS06035	COG0720	synthase
D9C16_RS06040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9C16_RS06045	COG3949	Membrane
D9C16_RS06050	COG0542	response to heat
D9C16_RS06055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9C16_RS06060	COG1360	Flagellar Motor Protein
D9C16_RS06065	COG1846	Transcriptional regulator
D9C16_RS06070	COG3852	Histidine kinase
D9C16_RS06085	COG3339	Conserved Protein
D9C16_RS06090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9C16_RS06095	COG0235	Class ii aldolase
D9C16_RS06100	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D9C16_RS06105	COG1850	ribulose-bisphosphate carboxylase activity
D9C16_RS06110	COG0436	Aminotransferase
D9C16_RS06115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9C16_RS06120	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D9C16_RS06125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9C16_RS06135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9C16_RS06140	COG5002	protein histidine kinase activity
D9C16_RS06145	COG3594	Acyltransferase
D9C16_RS06165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9C16_RS06170	COG0501	Belongs to the peptidase M48B family
D9C16_RS06190	COG1191	sigma factor activity
D9C16_RS06195	COG0861	Integral membrane protein TerC family
D9C16_RS06200	COG0586	Pfam SNARE associated Golgi protein
D9C16_RS06205	COG3300	MHYT domain
D9C16_RS06205	COG5001	Diguanylate cyclase
D9C16_RS06210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D9C16_RS06215	COG1793	dna ligase
D9C16_RS06215	COG3285	dna ligase
D9C16_RS06220	COG0463	Glycosyl transferase, family 2
D9C16_RS06230	COG1408	metallophosphoesterase
D9C16_RS06235	COG0726	polysaccharide deacetylase
D9C16_RS06240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C16_RS06245	COG1846	Transcriptional regulator
D9C16_RS06260	COG0789	Transcriptional regulator
D9C16_RS06265	COG2239	Acts as a magnesium transporter
D9C16_RS06280	COG3212	peptidase
D9C16_RS06285	COG3212	peptidase
D9C16_RS06290	COG5002	protein histidine kinase activity
D9C16_RS06290	COG3850	Histidine kinase
D9C16_RS06295	COG0745	RESPONSE REGULATOR receiver
D9C16_RS06305	COG4721	ABC-type cobalt transport system, permease component
D9C16_RS06310	COG1122	ATPase activity
D9C16_RS06315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D9C16_RS06320	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS06325	COG1404	Belongs to the peptidase S8 family
D9C16_RS06330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C16_RS06335	COG0590	tRNA wobble adenosine to inosine editing
D9C16_RS06345	COG1764	response to oxidative stress
D9C16_RS06350	COG1846	Transcriptional regulator
D9C16_RS06355	COG1764	response to oxidative stress
D9C16_RS06360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9C16_RS06365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9C16_RS06370	COG0788	formyltetrahydrofolate deformylase activity
D9C16_RS06375	COG2076	Multidrug Resistance protein
D9C16_RS06380	COG2076	Multidrug Resistance protein
D9C16_RS06385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS06390	COG2318	DinB family
D9C16_RS06395	COG2323	membrane
D9C16_RS06405	COG1017	nitric oxide dioxygenase activity
D9C16_RS06405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9C16_RS06410	COG1607	acyl-coa hydrolase
D9C16_RS06420	COG2706	6-phosphogluconolactonase activity
D9C16_RS06425	COG4608	Belongs to the ABC transporter superfamily
D9C16_RS06430	COG0791	NLP P60 protein
D9C16_RS06435	COG4948	Mandelate Racemase Muconate Lactonizing
D9C16_RS06440	COG1619	proteins homologs of microcin C7 resistance protein MccF
D9C16_RS06445	COG4166	transmembrane transport
D9C16_RS06450	COG0444	Belongs to the ABC transporter superfamily
D9C16_RS06455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C16_RS06460	COG0601	transmembrane transport
D9C16_RS06465	COG2362	D-Aminopeptidase
D9C16_RS06470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C16_RS06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C16_RS06480	COG0463	Glycosyl transferase, family 2
D9C16_RS06485	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D9C16_RS06490	COG0346	lactoylglutathione lyase activity
D9C16_RS06495	COG0531	amino acid
D9C16_RS06500	COG1392	Phosphate transport regulator
D9C16_RS06505	COG0306	phosphate transporter
D9C16_RS06565	COG3778	Protein conserved in bacteria
D9C16_RS06570	COG3299	homolog of phage Mu protein gp47
D9C16_RS06575	COG3628	GPW Gp25 family protein
D9C16_RS06585	COG4193	domain, Protein
D9C16_RS06590	COG1652	LysM domain
D9C16_RS06645	COG4653	Phage capsid family
D9C16_RS06650	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D9C16_RS06655	COG5518	Phage portal protein
D9C16_RS06660	COG1783	phage Terminase large subunit
D9C16_RS06665	COG3728	DNA packaging
D9C16_RS06665	COG5484	DNA packaging
D9C16_RS06670	COG1595	DNA-templated transcription, initiation
D9C16_RS06690	COG1484	DNA-dependent DNA replication
D9C16_RS06695	COG1522	sequence-specific DNA binding
D9C16_RS06705	COG1396	sequence-specific DNA binding
D9C16_RS06710	COG2856	Zn peptidase
D9C16_RS06715	COG3546	catalase activity
D9C16_RS06720	COG4195	phage-related replication protein
D9C16_RS06730	COG1388	LysM domain
D9C16_RS06730	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS06730	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS06745	COG0457	Tetratricopeptide repeat
D9C16_RS06765	COG2318	DinB family
D9C16_RS06770	COG0730	response to heat
D9C16_RS06775	COG2721	sulfolactate sulfo-lyase activity
D9C16_RS06785	COG1609	Transcriptional regulator
D9C16_RS06790	COG2271	Major facilitator Superfamily
D9C16_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS06800	COG1312	Catalyzes the dehydration of D-mannonate
D9C16_RS06805	COG1063	alcohol dehydrogenase
D9C16_RS06810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9C16_RS06815	COG2211	Major facilitator Superfamily
D9C16_RS06820	COG1904	glucuronate isomerase
D9C16_RS06825	COG1252	NADH dehydrogenase
D9C16_RS06840	COG0697	spore germination
D9C16_RS06845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C16_RS06850	COG0390	transport system, permease component
D9C16_RS06855	COG1587	Uroporphyrinogen-III synthase
D9C16_RS06865	COG1819	glycosyl
D9C16_RS06870	COG2124	cytochrome p450
D9C16_RS06880	COG1051	belongs to the nudix hydrolase family
D9C16_RS06890	COG2427	Protein of unknown function (DUF1641)
D9C16_RS06905	COG2205	protein histidine kinase activity
D9C16_RS06910	COG5504	Zn-dependent protease
D9C16_RS06925	COG0726	polysaccharide deacetylase
D9C16_RS06935	COG0109	protoheme IX farnesyltransferase activity
D9C16_RS06955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9C16_RS06965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS06970	COG3328	transposase activity
D9C16_RS06985	COG1482	cell wall glycoprotein biosynthetic process
D9C16_RS06995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS06995	COG3711	transcriptional antiterminator
D9C16_RS07005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D9C16_RS07065	COG3328	transposase activity
D9C16_RS07080	COG5444	nuclease activity
D9C16_RS07085	COG0457	Tetratricopeptide repeat
D9C16_RS07150	COG1396	sequence-specific DNA binding
D9C16_RS07185	COG5505	Protein of unknown function (DUF819)
D9C16_RS07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS07195	COG0626	cystathionine gamma-synthase activity
D9C16_RS07200	COG0626	cystathionine gamma-synthase activity
D9C16_RS07205	COG2382	esterase
D9C16_RS07210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9C16_RS07215	COG2153	protein acetylation
D9C16_RS07225	COG0210	DNA helicase
D9C16_RS07280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9C16_RS07285	COG0351	phosphomethylpyrimidine kinase
D9C16_RS07290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C16_RS07295	COG2022	thiamine diphosphate biosynthetic process
D9C16_RS07300	COG2104	thiamine diphosphate biosynthetic process
D9C16_RS07305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9C16_RS07310	COG0352	thiamine-phosphate diphosphorylase activity
D9C16_RS07315	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D9C16_RS07320	COG0475	glutathione-regulated potassium exporter activity
D9C16_RS07320	COG0569	domain protein
D9C16_RS07325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9C16_RS07330	COG0564	pseudouridine synthase activity
D9C16_RS07335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9C16_RS07340	COG2357	RelA SpoT domain protein
D9C16_RS07350	COG4116	CYTH
D9C16_RS07355	COG0741	lytic transglycosylase activity
D9C16_RS07360	COG2346	COG2346, Truncated hemoglobins
D9C16_RS07365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9C16_RS07380	COG1164	Oligoendopeptidase f
D9C16_RS07385	COG4469	Competence protein
D9C16_RS07395	COG4862	establishment of competence for transformation
D9C16_RS07405	COG0861	Integral membrane protein TerC family
D9C16_RS07410	COG1393	Belongs to the ArsC family
D9C16_RS07415	COG0456	acetyltransferase
D9C16_RS07420	COG2814	Major facilitator Superfamily
D9C16_RS07425	COG4608	Belongs to the ABC transporter superfamily
D9C16_RS07435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C16_RS07440	COG0601	transmembrane transport
D9C16_RS07445	COG4166	transmembrane transport
D9C16_RS07450	COG0180	Tryptophanyl-tRNA synthetase
D9C16_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C16_RS07465	COG0601	transmembrane transport
D9C16_RS07475	COG4608	Belongs to the ABC transporter superfamily
D9C16_RS07480	COG0444	Belongs to the ABC transporter superfamily
D9C16_RS07485	COG5504	Zn-dependent protease
D9C16_RS07490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9C16_RS07495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9C16_RS07510	COG1744	ABC transporter substrate-binding protein PnrA-like
D9C16_RS07520	COG2267	carboxylic ester hydrolase activity
D9C16_RS07540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9C16_RS07545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9C16_RS07550	COG0505	Belongs to the CarA family
D9C16_RS07555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9C16_RS07565	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9C16_RS07570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9C16_RS07590	COG2151	metal-sulfur cluster biosynthetic enzyme
D9C16_RS07595	COG1073	alpha beta
D9C16_RS07600	COG0561	phosphatase activity
D9C16_RS07615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS07620	COG1307	EDD domain protein, DegV family
D9C16_RS07630	COG2996	Protein conserved in bacteria
D9C16_RS07635	COG1666	GTP binding
D9C16_RS07640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9C16_RS07640	COG0646	methionine synthase
D9C16_RS07645	COG2153	protein acetylation
D9C16_RS07655	COG2267	carboxylic ester hydrolase activity
D9C16_RS07660	COG1357	PFAM Pentapeptide repeats (8 copies)
D9C16_RS07665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS07670	COG1279	arginine transmembrane transporter activity
D9C16_RS07675	COG2318	DinB family
D9C16_RS07680	COG0673	inositol 2-dehydrogenase activity
D9C16_RS07685	COG1609	Transcriptional regulator
D9C16_RS07690	COG2207	Transcriptional regulator
D9C16_RS07690	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS07695	COG0534	Mate efflux family protein
D9C16_RS07700	COG1562	ergosterol biosynthetic process
D9C16_RS07705	COG0367	asparagine synthase
D9C16_RS07715	COG1404	Belongs to the peptidase S8 family
D9C16_RS07725	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9C16_RS07730	COG5337	Spore coat protein CotH
D9C16_RS07770	COG1403	HNH endonuclease
D9C16_RS07775	COG0419	ATPase involved in DNA repair
D9C16_RS07780	COG0420	3'-5' exonuclease activity
D9C16_RS07785	COG1074	ATP-dependent DNA helicase activity
D9C16_RS07790	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D9C16_RS07795	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D9C16_RS07815	COG4533	DNA binding
D9C16_RS07820	COG0477	Major facilitator Superfamily
D9C16_RS07820	COG2814	Major facilitator Superfamily
D9C16_RS07825	COG3180	Ammonia monooxygenase
D9C16_RS07830	COG1609	Transcriptional regulator
D9C16_RS07835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C16_RS07840	COG0561	phosphatase activity
D9C16_RS07845	COG0673	inositol 2-dehydrogenase activity
D9C16_RS07850	COG0738	Major facilitator superfamily
D9C16_RS07865	COG1846	Transcriptional regulator
D9C16_RS07870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9C16_RS07875	COG0681	Belongs to the peptidase S26 family
D9C16_RS07880	COG0398	Pfam SNARE associated Golgi protein
D9C16_RS07895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C16_RS07905	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS07910	COG4903	ComK protein
D9C16_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS07930	COG0840	transmembrane signaling receptor activity
D9C16_RS07935	COG1268	BioY protein
D9C16_RS07940	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS07945	COG0183	Belongs to the thiolase family
D9C16_RS07950	COG0406	alpha-ribazole phosphatase activity
D9C16_RS07955	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D9C16_RS07960	COG0604	alcohol dehydrogenase
D9C16_RS07965	COG0456	acetyltransferase
D9C16_RS07975	COG0501	Belongs to the peptidase M48B family
D9C16_RS07985	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS07990	COG0702	epimerase
D9C16_RS07995	COG0095	Lipoate-protein ligase
D9C16_RS08000	COG1234	tRNA 3'-trailer cleavage
D9C16_RS08010	COG1301	dicarboxylic acid transport
D9C16_RS08015	COG4405	Protein conserved in bacteria
D9C16_RS08020	COG1363	Peptidase, m42
D9C16_RS08030	COG4377	Putative membrane peptidase family (DUF2324)
D9C16_RS08035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9C16_RS08040	COG1511	domain protein
D9C16_RS08045	COG1309	transcriptional regulator
D9C16_RS08050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D9C16_RS08055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9C16_RS08060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9C16_RS08065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C16_RS08070	COG2329	Antibiotic biosynthesis monooxygenase
D9C16_RS08085	COG1473	amidohydrolase
D9C16_RS08095	COG4473	ABC transporter
D9C16_RS08100	COG1131	(ABC) transporter
D9C16_RS08105	COG0537	adenosine 5'-monophosphoramidase activity
D9C16_RS08110	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9C16_RS08125	COG4980	gas vesicle protein
D9C16_RS08130	COG1846	Transcriptional regulator
D9C16_RS08160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9C16_RS08170	COG3481	metal-dependent phosphohydrolase, HD sub domain
D9C16_RS08175	COG4717	serine-type aminopeptidase activity
D9C16_RS08180	COG0420	3'-5' exonuclease activity
D9C16_RS08185	COG1668	transmembrane transport
D9C16_RS08190	COG4152	abc transporter atp-binding protein
D9C16_RS08200	COG1024	Enoyl-CoA hydratase
D9C16_RS08210	COG0490	domain, Protein
D9C16_RS08215	COG0475	glutathione-regulated potassium exporter activity
D9C16_RS08220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9C16_RS08225	COG0561	phosphatase activity
D9C16_RS08235	COG3679	Belongs to the UPF0342 family
D9C16_RS08240	COG4399	Belongs to the UPF0754 family
D9C16_RS08245	COG0189	ligase activity
D9C16_RS08250	COG0189	ligase activity
D9C16_RS08275	COG0702	epimerase
D9C16_RS08280	COG1132	(ABC) transporter
D9C16_RS08285	COG1132	(ABC) transporter
D9C16_RS08295	COG0589	response to stress
D9C16_RS08300	COG1757	Na H antiporter
D9C16_RS08305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C16_RS08310	COG0726	polysaccharide deacetylase
D9C16_RS08315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9C16_RS08320	COG0668	transmembrane transport
D9C16_RS08330	COG0584	glycerophosphoryl diester phosphodiesterase
D9C16_RS08335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9C16_RS08340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9C16_RS08345	COG1253	flavin adenine dinucleotide binding
D9C16_RS08355	COG0789	Transcriptional regulator
D9C16_RS08360	COG1253	flavin adenine dinucleotide binding
D9C16_RS08365	COG0204	Acyl-transferase
D9C16_RS08370	COG0667	Aldo Keto reductase
D9C16_RS08375	COG1595	DNA-templated transcription, initiation
D9C16_RS08390	COG0456	acetyltransferase
D9C16_RS08395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS08400	COG0733	neurotransmitter:sodium symporter activity
D9C16_RS08405	COG0531	amino acid
D9C16_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS08415	COG0372	Belongs to the citrate synthase family
D9C16_RS08420	COG0583	DNA-binding transcription factor activity
D9C16_RS08425	COG0791	NLP P60 protein
D9C16_RS08425	COG1388	LysM domain
D9C16_RS08430	COG1785	Belongs to the alkaline phosphatase family
D9C16_RS08435	COG2719	SpoVR family
D9C16_RS08440	COG0668	transmembrane transport
D9C16_RS08445	COG1959	2 iron, 2 sulfur cluster binding
D9C16_RS08450	COG0791	NLP P60 protein
D9C16_RS08450	COG1388	LysM domain
D9C16_RS08465	COG0431	NADPH-dependent FMN reductase
D9C16_RS08470	COG2197	response regulator
D9C16_RS08475	COG2203	Gaf domain
D9C16_RS08475	COG4585	Histidine kinase
D9C16_RS08485	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9C16_RS08490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9C16_RS08495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D9C16_RS08500	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D9C16_RS08505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C16_RS08510	COG3153	acetyltransferase
D9C16_RS08510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9C16_RS08515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9C16_RS08520	COG0517	IMP dehydrogenase activity
D9C16_RS08530	COG0564	pseudouridine synthase activity
D9C16_RS08535	COG3764	Sortase (surface protein transpeptidase)
D9C16_RS08540	COG4085	toxin activity
D9C16_RS08540	COG0737	Belongs to the 5'-nucleotidase family
D9C16_RS08540	COG1525	nuclease
D9C16_RS08565	COG0457	Tetratricopeptide repeat
D9C16_RS08585	COG0791	NLP P60 protein
D9C16_RS08585	COG0741	lytic transglycosylase activity
D9C16_RS08590	COG5644	endopeptidase inhibitor activity
D9C16_RS08640	COG2946	Replication initiation factor
D9C16_RS08645	COG0582	viral genome integration into host DNA
D9C16_RS08670	COG5444	nuclease activity
D9C16_RS08675	COG1823	symporter activity
D9C16_RS08680	COG3706	GGDEF domain
D9C16_RS08685	COG1464	Belongs to the NlpA lipoprotein family
D9C16_RS08695	COG1278	Cold shock
D9C16_RS08700	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C16_RS08705	COG1131	(ABC) transporter
D9C16_RS08710	COG1131	(ABC) transporter
D9C16_RS08715	COG1725	Transcriptional regulator
D9C16_RS08735	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9C16_RS08740	COG2814	Major facilitator Superfamily
D9C16_RS08745	COG1566	PFAM secretion protein HlyD family protein
D9C16_RS08750	COG1846	Transcriptional regulator
D9C16_RS08755	COG2718	Belongs to the UPF0229 family
D9C16_RS08760	COG2766	serine protein kinase
D9C16_RS08765	COG1664	Polymer-forming cytoskeletal
D9C16_RS08770	COG1664	Polymer-forming cytoskeletal
D9C16_RS08775	COG0789	Transcriptional regulator
D9C16_RS08780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9C16_RS08790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D9C16_RS08795	COG3382	B3 4 domain protein
D9C16_RS08805	COG1476	TRANSCRIPTIONal
D9C16_RS08815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9C16_RS08825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C16_RS08830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9C16_RS08835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9C16_RS08840	COG1116	anion transmembrane transporter activity
D9C16_RS08845	COG0753	catalase activity
D9C16_RS08860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9C16_RS08870	COG5577	PFAM Coat F domain
D9C16_RS08880	COG4326	sporulation control protein
D9C16_RS08990	COG0735	belongs to the Fur family
D9C16_RS08995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9C16_RS09000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9C16_RS09005	COG4129	membrane
D9C16_RS09010	COG1132	(ABC) transporter
D9C16_RS09015	COG3557	Belongs to the UPF0374 family
D9C16_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS09040	COG1194	a g-specific adenine glycosylase
D9C16_RS09045	COG1988	membrane-bound metal-dependent
D9C16_RS09050	COG4485	Bacterial membrane protein, YfhO
D9C16_RS09055	COG0463	Glycosyl transferase, family 2
D9C16_RS09060	COG0596	Alpha beta hydrolase
D9C16_RS09065	COG5658	integral membrane protein
D9C16_RS09070	COG3103	Sh3 type 3 domain protein
D9C16_RS09085	COG2814	Major facilitator Superfamily
D9C16_RS09095	COG2137	regulation of response to DNA damage stimulus
D9C16_RS09100	COG1090	epimerase
D9C16_RS09115	COG0778	Nitroreductase
D9C16_RS09125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS09130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS09135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS09140	COG0392	lysyltransferase activity
D9C16_RS09140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D9C16_RS09145	COG1846	Transcriptional regulator
D9C16_RS09155	COG2318	DinB family
D9C16_RS09160	COG2814	Major facilitator Superfamily
D9C16_RS09165	COG1309	transcriptional regulator
D9C16_RS09170	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D9C16_RS09175	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D9C16_RS09180	COG1695	Transcriptional regulator
D9C16_RS09185	COG0842	Transport permease protein
D9C16_RS09190	COG0842	Transport permease protein
D9C16_RS09190	COG1511	domain protein
D9C16_RS09195	COG1131	(ABC) transporter
D9C16_RS09200	COG2197	response regulator
D9C16_RS09205	COG4585	Histidine kinase
D9C16_RS09215	COG1082	Xylose isomerase domain protein TIM barrel
D9C16_RS09220	COG2814	Major facilitator Superfamily
D9C16_RS09225	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS09225	COG4977	sequence-specific DNA binding
D9C16_RS09230	COG2514	catechol 2,3-dioxygenase activity
D9C16_RS09235	COG2259	Doxx family
D9C16_RS09240	COG1132	(ABC) transporter
D9C16_RS09245	COG1132	(ABC) transporter
D9C16_RS09250	COG5434	Belongs to the glycosyl hydrolase 28 family
D9C16_RS09255	COG1263	PTS System
D9C16_RS09255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS09260	COG1737	Transcriptional regulator
D9C16_RS09265	COG1486	melibiose metabolic process
D9C16_RS09270	COG4842	Belongs to the WXG100 family
D9C16_RS09295	COG1742	UPF0060 membrane protein
D9C16_RS09305	COG3284	Transcriptional regulator
D9C16_RS09310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C16_RS09315	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C16_RS09320	COG0022	dehydrogenase e1 component
D9C16_RS09325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C16_RS09335	COG4637	Psort location Cytoplasmic, score
D9C16_RS09340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9C16_RS09350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9C16_RS09355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D9C16_RS09360	COG0598	Magnesium transport protein CorA
D9C16_RS09365	COG2084	Dehydrogenase
D9C16_RS09370	COG0726	polysaccharide deacetylase
D9C16_RS09380	COG0535	radical SAM domain protein
D9C16_RS09385	COG0668	transmembrane transport
D9C16_RS09395	COG0387	Pfam Sodium calcium exchanger
D9C16_RS09400	COG0477	Major facilitator Superfamily
D9C16_RS09405	COG1295	ribonuclease BN
D9C16_RS09410	COG4980	gas vesicle protein
D9C16_RS09415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9C16_RS09420	COG4840	Belongs to the UPF0435 family
D9C16_RS09425	COG2814	Major facilitator Superfamily
D9C16_RS09435	COG0693	protein deglycase activity
D9C16_RS09440	COG0737	Belongs to the 5'-nucleotidase family
D9C16_RS09445	COG0778	Nitroreductase
D9C16_RS09450	COG2188	Transcriptional regulator
D9C16_RS09455	COG0366	Alpha amylase catalytic
D9C16_RS09460	COG1263	PTS System
D9C16_RS09460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS09465	COG0697	spore germination
D9C16_RS09480	COG1115	amino acid carrier protein
D9C16_RS09495	COG1368	sulfuric ester hydrolase activity
D9C16_RS09500	COG1263	PTS System
D9C16_RS09500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS09505	COG0024	Methionine aminopeptidase
D9C16_RS09525	COG2258	MOSC domain
D9C16_RS09530	COG1254	Belongs to the acylphosphatase family
D9C16_RS09535	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D9C16_RS09540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS09545	COG2851	Citrate transporter
D9C16_RS09550	COG3181	Tripartite tricarboxylate transporter family receptor
D9C16_RS09555	COG4565	transcriptional regulatory protein
D9C16_RS09560	COG3290	protein histidine kinase activity
D9C16_RS09565	COG0471	metal ion transport
D9C16_RS09570	COG3866	Pectate lyase
D9C16_RS09580	COG0513	Belongs to the DEAD box helicase family
D9C16_RS09585	COG0488	(ABC) transporter
D9C16_RS09605	COG2814	Major facilitator Superfamily
D9C16_RS09610	COG0789	Transcriptional regulator
D9C16_RS09620	COG0488	(ABC) transporter
D9C16_RS09625	COG0840	transmembrane signaling receptor activity
D9C16_RS09630	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS09635	COG0531	amino acid
D9C16_RS09640	COG1011	Hydrolase
D9C16_RS09645	COG2223	nitrite transmembrane transporter activity
D9C16_RS09650	COG1442	glycosyl transferase family 8
D9C16_RS09655	COG1216	Glycosyl transferase, family 2
D9C16_RS09660	COG1442	glycosyl transferase family 8
D9C16_RS09665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C16_RS09670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9C16_RS09675	COG1368	sulfuric ester hydrolase activity
D9C16_RS09685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9C16_RS09685	COG2124	cytochrome p450
D9C16_RS09695	COG3328	transposase activity
D9C16_RS09710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9C16_RS09715	COG0670	Belongs to the BI1 family
D9C16_RS09720	COG5583	Uncharacterized small protein (DUF2292)
D9C16_RS09735	COG0346	lactoylglutathione lyase activity
D9C16_RS09740	COG2329	Antibiotic biosynthesis monooxygenase
D9C16_RS09745	COG2323	membrane
D9C16_RS09750	COG1486	melibiose metabolic process
D9C16_RS09755	COG0395	ABC-type sugar transport system, permease component
D9C16_RS09760	COG4209	transmembrane transport
D9C16_RS09765	COG1653	transport
D9C16_RS09780	COG2755	lipolytic protein G-D-S-L family
D9C16_RS09785	COG3401	FG-GAP repeat protein
D9C16_RS09790	COG3401	FG-GAP repeat protein
D9C16_RS09795	COG5578	integral membrane protein
D9C16_RS09805	COG2755	lipolytic protein G-D-S-L family
D9C16_RS09810	COG2207	Transcriptional regulator
D9C16_RS09815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9C16_RS09820	COG0395	ABC-type sugar transport system, permease component
D9C16_RS09825	COG1175	transmembrane transport
D9C16_RS09830	COG1653	transport
D9C16_RS09840	COG2972	Histidine kinase
D9C16_RS09845	COG5578	integral membrane protein
D9C16_RS09855	COG0454	-acetyltransferase
D9C16_RS09860	COG3546	catalase activity
D9C16_RS09875	COG1309	transcriptional regulator
D9C16_RS09885	COG0217	transcriptional regulatory protein
D9C16_RS09895	COG0457	Tetratricopeptide repeat
D9C16_RS09905	COG5444	nuclease activity
D9C16_RS09940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9C16_RS09945	COG1597	lipid kinase activity
D9C16_RS09950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9C16_RS09955	COG1309	transcriptional regulator
D9C16_RS09960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9C16_RS09965	COG0154	amidase activity
D9C16_RS09970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9C16_RS09975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C16_RS09980	COG1285	pathogenesis
D9C16_RS09985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C16_RS09995	COG4851	CamS sex pheromone cAM373 precursor
D9C16_RS10005	COG0210	DNA helicase
D9C16_RS10010	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D9C16_RS10015	COG0069	glutamate synthase activity
D9C16_RS10020	COG4496	protein, YerC YecD
D9C16_RS10025	COG1470	cell adhesion involved in biofilm formation
D9C16_RS10030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9C16_RS10040	COG0531	amino acid
D9C16_RS10045	COG1522	sequence-specific DNA binding
D9C16_RS10050	COG0151	Belongs to the GarS family
D9C16_RS10055	COG0138	bifunctional purine biosynthesis protein purh
D9C16_RS10060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9C16_RS10065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9C16_RS10070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9C16_RS10075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9C16_RS10080	COG0047	phosphoribosylformylglycinamidine synthase activity
D9C16_RS10085	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9C16_RS10090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9C16_RS10095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9C16_RS10100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9C16_RS10105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D9C16_RS10115	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D9C16_RS10125	COG3064	Membrane
D9C16_RS10130	COG2252	PERMEase
D9C16_RS10140	COG0519	Catalyzes the synthesis of GMP from XMP
D9C16_RS10140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9C16_RS10145	COG1305	Transglutaminase-like
D9C16_RS10150	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D9C16_RS10155	COG0714	Associated with various cellular activities
D9C16_RS10160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C16_RS10170	COG1113	amino acid transport
D9C16_RS10175	COG2132	Multicopper oxidase
D9C16_RS10185	COG2267	carboxylic ester hydrolase activity
D9C16_RS10205	COG0823	Involved in the tonB-independent uptake of proteins
D9C16_RS10210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9C16_RS10215	COG1063	alcohol dehydrogenase
D9C16_RS10220	COG2814	Major facilitator Superfamily
D9C16_RS10230	COG4260	virion core protein, lumpy skin disease virus
D9C16_RS10235	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D9C16_RS10240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9C16_RS10250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C16_RS10255	COG2211	Major facilitator Superfamily
D9C16_RS10260	COG1063	alcohol dehydrogenase
D9C16_RS10265	COG0457	Tetratricopeptide repeat
D9C16_RS10280	COG0459	protein refolding
D9C16_RS10290	COG1266	CAAX protease self-immunity
D9C16_RS10305	COG0805	protein transport
D9C16_RS10310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C16_RS10315	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D9C16_RS10320	COG0315	cyclic pyranopterin monophosphate synthase activity
D9C16_RS10325	COG0488	(ABC) transporter
D9C16_RS10335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9C16_RS10340	COG0456	acetyltransferase
D9C16_RS10345	COG1214	PFAM Peptidase M22, glycoprotease
D9C16_RS10350	COG0802	atpase or kinase
D9C16_RS10355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9C16_RS10400	COG4124	Belongs to the glycosyl hydrolase 26 family
D9C16_RS10410	COG1940	carbohydrate kinase activity
D9C16_RS10415	COG2188	Transcriptional regulator
D9C16_RS10420	COG2723	6-phospho-beta-galactosidase activity
D9C16_RS10435	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C16_RS10440	COG2814	Major facilitator Superfamily
D9C16_RS10445	COG1388	LysM domain
D9C16_RS10450	COG1078	dGTPase activity
D9C16_RS10455	COG0454	-acetyltransferase
D9C16_RS10465	COG5646	InterPro IPR014922
D9C16_RS10470	COG1785	Belongs to the alkaline phosphatase family
D9C16_RS10480	COG1819	glycosyl
D9C16_RS10485	COG1388	LysM domain
D9C16_RS10485	COG3858	chitin binding
D9C16_RS10490	COG1802	Transcriptional regulator
D9C16_RS10495	COG0730	response to heat
D9C16_RS10500	COG2814	Major facilitator Superfamily
D9C16_RS10505	COG1846	Transcriptional regulator
D9C16_RS10510	COG0778	Nitroreductase
D9C16_RS10515	COG1033	growth of symbiont in host cell
D9C16_RS10515	COG2409	Drug exporters of the RND superfamily
D9C16_RS10520	COG1846	Transcriptional regulator
D9C16_RS10525	COG2318	DinB family
D9C16_RS10530	COG1113	amino acid transport
D9C16_RS10535	COG0488	(ABC) transporter
D9C16_RS10540	COG0456	acetyltransferase
D9C16_RS10550	COG1309	transcriptional regulator
D9C16_RS10565	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C16_RS10570	COG2323	membrane
D9C16_RS10595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS10600	COG2259	Doxx family
D9C16_RS10605	COG0346	lactoylglutathione lyase activity
D9C16_RS10610	COG0778	Nitroreductase
D9C16_RS10615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C16_RS10620	COG0789	Transcriptional regulator
D9C16_RS10620	COG4978	Transcriptional regulator
D9C16_RS10625	COG1811	Na channel or pump
D9C16_RS10630	COG0596	Alpha beta hydrolase
D9C16_RS10635	COG2409	Drug exporters of the RND superfamily
D9C16_RS10640	COG2197	response regulator
D9C16_RS10645	COG4585	Histidine kinase
D9C16_RS10660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9C16_RS10665	COG0640	Transcriptional regulator
D9C16_RS10670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9C16_RS10675	COG0076	glutamate decarboxylase activity
D9C16_RS10680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS10685	COG0697	spore germination
D9C16_RS10690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS10700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9C16_RS10705	COG0640	Transcriptional regulator
D9C16_RS10710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS10720	COG3545	Serine hydrolase
D9C16_RS10725	COG2030	dehydratase
D9C16_RS10730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS10735	COG0697	spore germination
D9C16_RS10740	COG1309	transcriptional regulator
D9C16_RS10745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS10760	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D9C16_RS10775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS10780	COG2207	Transcriptional regulator
D9C16_RS10780	COG3708	Transcriptional regulator
D9C16_RS10790	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS10790	COG2207	Transcriptional regulator
D9C16_RS10795	COG0697	spore germination
D9C16_RS10805	COG1329	Transcriptional regulator
D9C16_RS10810	COG1278	Cold shock
D9C16_RS10815	COG0693	protein deglycase activity
D9C16_RS10840	COG1476	TRANSCRIPTIONal
D9C16_RS10850	COG5444	nuclease activity
D9C16_RS10860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS10865	COG0583	DNA-binding transcription factor activity
D9C16_RS10900	COG0457	Tetratricopeptide repeat
D9C16_RS10915	COG0741	lytic transglycosylase activity
D9C16_RS10915	COG0791	NLP P60 protein
D9C16_RS10925	COG5644	endopeptidase inhibitor activity
D9C16_RS10935	COG0433	COG0433 Predicted ATPase
D9C16_RS10975	COG2946	Replication initiation factor
D9C16_RS10980	COG1674	ftsk spoiiie
D9C16_RS11010	COG1396	sequence-specific DNA binding
D9C16_RS11015	COG2856	Zn peptidase
D9C16_RS11020	COG0582	viral genome integration into host DNA
D9C16_RS11060	COG3091	SprT-like family
D9C16_RS11070	COG2183	response to ionizing radiation
D9C16_RS11075	COG1846	Transcriptional regulator
D9C16_RS11080	COG1673	EVE domain
D9C16_RS11095	COG2208	phosphoserine phosphatase activity
D9C16_RS11100	COG1191	sigma factor activity
D9C16_RS11105	COG2172	sigma factor antagonist activity
D9C16_RS11110	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS11115	COG2208	phosphoserine phosphatase activity
D9C16_RS11120	COG2172	sigma factor antagonist activity
D9C16_RS11125	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS11130	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS11135	COG2337	Toxic component of a toxin-antitoxin (TA) module
D9C16_RS11140	COG0864	Transcriptional regulator
D9C16_RS11145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9C16_RS11150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9C16_RS11155	COG0736	holo-[acyl-carrier-protein] synthase activity
D9C16_RS11160	COG0705	Rhomboid family
D9C16_RS11165	COG3428	Bacterial PH domain
D9C16_RS11170	COG3402	PFAM membrane-flanked domain
D9C16_RS11175	COG0513	Belongs to the DEAD box helicase family
D9C16_RS11185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9C16_RS11190	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9C16_RS11195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS11200	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C16_RS11215	COG1960	acyl-CoA dehydrogenase activity
D9C16_RS11225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C16_RS11230	COG1131	(ABC) transporter
D9C16_RS11235	COG0628	permease
D9C16_RS11240	COG1301	dicarboxylic acid transport
D9C16_RS11245	COG4565	transcriptional regulatory protein
D9C16_RS11250	COG3290	protein histidine kinase activity
D9C16_RS11255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9C16_RS11260	COG3546	catalase activity
D9C16_RS11265	COG2329	Antibiotic biosynthesis monooxygenase
D9C16_RS11270	COG0662	Cupin 2, conserved barrel domain protein
D9C16_RS11275	COG3729	General stress protein
D9C16_RS11280	COG2217	Heavy metal translocating P-type atpase
D9C16_RS11285	COG4876	unkown
D9C16_RS11290	COG2261	transglycosylase associated protein
D9C16_RS11295	COG1914	H( )-stimulated, divalent metal cation uptake system
D9C16_RS11325	COG0028	Belongs to the TPP enzyme family
D9C16_RS11330	COG0494	nUDIX hydrolase
D9C16_RS11335	COG0551	DNA topoisomerase type I activity
D9C16_RS11335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9C16_RS11340	COG1522	sequence-specific DNA binding
D9C16_RS11345	COG2814	Major facilitator Superfamily
D9C16_RS11355	COG3871	stress protein (general stress protein 26)
D9C16_RS11360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS11370	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS11375	COG2226	methyltransferase
D9C16_RS11380	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS11385	COG3711	transcriptional antiterminator
D9C16_RS11390	COG4989	oxidoreductase activity
D9C16_RS11395	COG0768	penicillin binding
D9C16_RS11400	COG2329	Antibiotic biosynthesis monooxygenase
D9C16_RS11410	COG2755	lipolytic protein G-D-S-L family
D9C16_RS11415	COG1414	Transcriptional regulator
D9C16_RS11420	COG1984	allophanate hydrolase subunit 2
D9C16_RS11425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9C16_RS11430	COG4336	lyase activity
D9C16_RS11435	COG1914	H( )-stimulated, divalent metal cation uptake system
D9C16_RS11440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9C16_RS11445	COG0561	phosphatase activity
D9C16_RS11455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9C16_RS11465	COG0681	Belongs to the peptidase S26 family
D9C16_RS11470	COG0473	3-isopropylmalate dehydrogenase activity
D9C16_RS11475	COG0246	Mannitol dehydrogenase
D9C16_RS11480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS11485	COG2213	PTS system mannitol-specific
D9C16_RS11495	COG1349	DNA-binding transcription factor activity
D9C16_RS11500	COG2372	response to copper ion
D9C16_RS11500	COG1276	copper resistance
D9C16_RS11505	COG4549	nuclear export factor GLE1
D9C16_RS11510	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS11520	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS11525	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9C16_RS11530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS11535	COG0640	Transcriptional regulator
D9C16_RS11540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D9C16_RS11545	COG0778	Nitroreductase
D9C16_RS11550	COG1309	transcriptional regulator
D9C16_RS11555	COG2814	Major facilitator Superfamily
D9C16_RS11565	COG4607	ABC-type enterochelin transport system periplasmic component
D9C16_RS11570	COG4604	ABC transporter, ATP-binding protein
D9C16_RS11575	COG4605	iron ion homeostasis
D9C16_RS11580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS11585	COG0527	aspartate kinase activity
D9C16_RS11605	COG0457	Tetratricopeptide repeat
D9C16_RS11610	COG5002	protein histidine kinase activity
D9C16_RS11610	COG3850	Histidine kinase
D9C16_RS11615	COG0745	RESPONSE REGULATOR receiver
D9C16_RS11620	COG0577	efflux transmembrane transporter activity
D9C16_RS11625	COG1136	(ABC) transporter
D9C16_RS11630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D9C16_RS11640	COG0697	spore germination
D9C16_RS11650	COG5434	Belongs to the glycosyl hydrolase 28 family
D9C16_RS11655	COG3104	oligopeptide transport
D9C16_RS11660	COG0596	Alpha beta hydrolase
D9C16_RS11675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9C16_RS11680	COG0163	prenyltransferase activity
D9C16_RS11685	COG0583	DNA-binding transcription factor activity
D9C16_RS11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C16_RS11695	COG0765	amino acid transport
D9C16_RS11700	COG1126	abc transporter atp-binding protein
D9C16_RS11705	COG2364	Membrane
D9C16_RS11715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C16_RS11720	COG0697	spore germination
D9C16_RS11730	COG2814	Major facilitator Superfamily
D9C16_RS11735	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D9C16_RS11740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS11745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS11750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS11755	COG1733	regulation of RNA biosynthetic process
D9C16_RS11760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D9C16_RS11765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9C16_RS11775	COG3209	COG3209 Rhs family protein
D9C16_RS11785	COG2723	6-phospho-beta-galactosidase activity
D9C16_RS11800	COG1846	Transcriptional regulator
D9C16_RS11810	COG1714	RDD family
D9C16_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C16_RS11825	COG0765	amino acid transport
D9C16_RS11840	COG1376	ErfK ybiS ycfS ynhG family protein
D9C16_RS11855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C16_RS11860	COG0243	molybdopterin cofactor binding
D9C16_RS11865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C16_RS11870	COG2146	nitrite reductase [NAD(P)H] activity
D9C16_RS11875	COG1587	Uroporphyrinogen-III synthase
D9C16_RS11875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9C16_RS11880	COG0492	ferredoxin-NADP+ reductase activity
D9C16_RS11885	COG2267	carboxylic ester hydrolase activity
D9C16_RS11890	COG0701	Predicted permease
D9C16_RS11895	COG3689	TIGRFAM TIGR03943 family protein
D9C16_RS11900	COG2508	Transcriptional regulator
D9C16_RS11905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C16_RS11910	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS11915	COG0506	proline dehydrogenase activity
D9C16_RS11920	COG3541	Predicted nucleotidyltransferase
D9C16_RS11925	COG3458	cephalosporin-C deacetylase activity
D9C16_RS11930	COG0583	DNA-binding transcription factor activity
D9C16_RS11935	COG2226	methyltransferase
D9C16_RS11945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D9C16_RS11955	COG1660	Displays ATPase and GTPase activities
D9C16_RS11960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9C16_RS11975	COG3403	YqcI/YcgG family
D9C16_RS11990	COG0039	L-malate dehydrogenase activity
D9C16_RS12005	COG1288	antiporter activity
D9C16_RS12010	COG1473	amidohydrolase
D9C16_RS12015	COG2113	Glycine betaine
D9C16_RS12020	COG4176	ABC-type proline glycine betaine transport system permease component
D9C16_RS12025	COG4175	Glycine betaine
D9C16_RS12025	COG0517	IMP dehydrogenase activity
D9C16_RS12030	COG0640	Transcriptional regulator
D9C16_RS12035	COG2814	Major facilitator Superfamily
D9C16_RS12040	COG0477	Major facilitator Superfamily
D9C16_RS12050	COG3853	Toxic anion resistance protein (TelA)
D9C16_RS12060	COG0861	Integral membrane protein TerC family
D9C16_RS12065	COG2310	stress, protein
D9C16_RS12070	COG2310	stress, protein
D9C16_RS12075	COG2310	stress, protein
D9C16_RS12085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C16_RS12090	COG1121	(ABC) transporter
D9C16_RS12095	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9C16_RS12100	COG0366	Alpha amylase catalytic
D9C16_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS12115	COG1876	peptidase activity
D9C16_RS12120	COG1595	DNA-templated transcription, initiation
D9C16_RS12125	COG1595	DNA-templated transcription, initiation
D9C16_RS12140	COG0667	Aldo Keto reductase
D9C16_RS12145	COG1668	transmembrane transport
D9C16_RS12155	COG3279	Response regulator of the LytR AlgR family
D9C16_RS12165	COG1405	negative regulation of cell septum assembly
D9C16_RS12165	COG3012	SEC-C Motif Domain Protein
D9C16_RS12170	COG1714	RDD family
D9C16_RS12175	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D9C16_RS12180	COG0252	asparaginase activity
D9C16_RS12185	COG1309	transcriptional regulator
D9C16_RS12190	COG0477	Major facilitator Superfamily
D9C16_RS12195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9C16_RS12200	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D9C16_RS12205	COG0805	protein transport
D9C16_RS12210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C16_RS12215	COG3540	Alkaline phosphatase
D9C16_RS12225	COG2304	oxidoreductase activity
D9C16_RS12230	COG3773	Cell wall hydrolase
D9C16_RS12250	COG1131	(ABC) transporter
D9C16_RS12255	COG2205	protein histidine kinase activity
D9C16_RS12260	COG0745	RESPONSE REGULATOR receiver
D9C16_RS12275	COG3173	Aminoglycoside phosphotransferase
D9C16_RS12280	COG2721	sulfolactate sulfo-lyase activity
D9C16_RS12285	COG2186	Transcriptional regulator
D9C16_RS12290	COG4948	Mandelate Racemase Muconate Lactonizing
D9C16_RS12295	COG2271	Major facilitator Superfamily
D9C16_RS12300	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS12305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9C16_RS12315	COG0784	Response regulator, receiver
D9C16_RS12320	COG4191	Histidine kinase
D9C16_RS12325	COG2066	Belongs to the glutaminase family
D9C16_RS12340	COG2040	homocysteine
D9C16_RS12345	COG0833	amino acid
D9C16_RS12350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C16_RS12360	COG2188	Transcriptional regulator
D9C16_RS12365	COG0363	glucosamine-6-phosphate deaminase activity
D9C16_RS12370	COG1263	PTS System
D9C16_RS12370	COG2190	(PTS) system
D9C16_RS12370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS12375	COG1301	dicarboxylic acid transport
D9C16_RS12380	COG1054	Belongs to the UPF0176 family
D9C16_RS12385	COG2207	Transcriptional regulator
D9C16_RS12390	COG2312	Erythromycin esterase
D9C16_RS12400	COG0688	phosphatidylethanolamine metabolic process
D9C16_RS12405	COG0586	Pfam SNARE associated Golgi protein
D9C16_RS12410	COG1183	phosphatidylcholine synthase activity
D9C16_RS12415	COG0596	Alpha beta hydrolase
D9C16_RS12425	COG3591	Belongs to the peptidase S1B family
D9C16_RS12430	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9C16_RS12455	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS12455	COG2207	Transcriptional regulator
D9C16_RS12460	COG0697	spore germination
D9C16_RS12465	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS12485	COG1846	Transcriptional regulator
D9C16_RS12485	COG0456	acetyltransferase
D9C16_RS12500	COG2271	Major facilitator Superfamily
D9C16_RS12505	COG0584	glycerophosphoryl diester phosphodiesterase
D9C16_RS12510	COG0531	amino acid
D9C16_RS12520	COG2124	cytochrome p450
D9C16_RS12525	COG2602	Beta-lactamase
D9C16_RS12540	COG1113	amino acid transport
D9C16_RS12555	COG0515	serine threonine protein kinase
D9C16_RS12565	COG0642	Histidine kinase
D9C16_RS12575	COG5609	conserved protein (DUF2294)
D9C16_RS12585	COG0288	reversible hydration of carbon dioxide
D9C16_RS12590	COG3002	Belongs to the UPF0753 family
D9C16_RS12595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9C16_RS12600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9C16_RS12605	COG2169	Transcriptional regulator
D9C16_RS12620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9C16_RS12630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9C16_RS12635	COG4856	YbbR-like protein
D9C16_RS12640	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9C16_RS12645	COG5662	AntiSigma factor
D9C16_RS12650	COG1595	DNA-templated transcription, initiation
D9C16_RS12680	COG1683	Conserved Protein
D9C16_RS12685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C16_RS12690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D9C16_RS12695	COG1737	Transcriptional regulator
D9C16_RS12700	COG1263	PTS System
D9C16_RS12700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS12705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9C16_RS12710	COG1472	Belongs to the glycosyl hydrolase 3 family
D9C16_RS12715	COG3876	Protein conserved in bacteria
D9C16_RS12720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS12720	COG2207	Transcriptional regulator
D9C16_RS12725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS12730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS12735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS12740	COG2819	hydrolase of the alpha beta superfamily
D9C16_RS12745	COG0385	Bile acid
D9C16_RS12750	COG0659	secondary active sulfate transmembrane transporter activity
D9C16_RS12835	COG0726	polysaccharide deacetylase
D9C16_RS12840	COG2194	sulfuric ester hydrolase activity
D9C16_RS12850	COG0489	protein tyrosine kinase activity
D9C16_RS12855	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS12865	COG2226	methyltransferase
D9C16_RS12875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9C16_RS12880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9C16_RS12885	COG0101	tRNA pseudouridine synthase activity
D9C16_RS12890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D9C16_RS12895	COG1122	ATPase activity
D9C16_RS12900	COG1122	ATPase activity
D9C16_RS12905	COG0203	ribosomal protein L17
D9C16_RS12910	COG0202	RNA polymerase activity
D9C16_RS12915	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D9C16_RS12920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9C16_RS12925	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9C16_RS12935	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D9C16_RS12940	COG0024	Methionine aminopeptidase
D9C16_RS12945	COG0563	adenylate kinase activity
D9C16_RS12950	COG0201	protein transport
D9C16_RS12965	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9C16_RS12970	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D9C16_RS12975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9C16_RS12980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9C16_RS12990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9C16_RS13000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9C16_RS13005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9C16_RS13015	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9C16_RS13020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9C16_RS13035	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9C16_RS13045	COG0088	Forms part of the polypeptide exit tunnel
D9C16_RS13050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9C16_RS13065	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9C16_RS13070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9C16_RS13075	COG0049	tRNA binding
D9C16_RS13080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9C16_RS13085	COG1358	cellular component organization or biogenesis
D9C16_RS13090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9C16_RS13095	COG0085	RNA polymerase activity
D9C16_RS13100	COG2813	Specifically methylates the guanine in position
D9C16_RS13110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9C16_RS13115	COG0081	regulation of translation
D9C16_RS13125	COG0250	Participates in transcription elongation, termination and antitermination
D9C16_RS13130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9C16_RS13140	COG1595	DNA-templated transcription, initiation
D9C16_RS13145	COG3688	RNA-binding protein containing a PIN domain
D9C16_RS13150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9C16_RS13155	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D9C16_RS13165	COG1045	serine acetyltransferase
D9C16_RS13175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9C16_RS13180	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D9C16_RS13185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D9C16_RS13190	COG4956	integral membrane protein (PIN domain superfamily)
D9C16_RS13195	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D9C16_RS13200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D9C16_RS13205	COG0542	response to heat
D9C16_RS13210	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D9C16_RS13215	COG3880	PFAM UvrB UvrC protein
D9C16_RS13220	COG4463	regulation of RNA biosynthetic process
D9C16_RS13300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9C16_RS13305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9C16_RS13310	COG1396	sequence-specific DNA binding
D9C16_RS13315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9C16_RS13320	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9C16_RS13325	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9C16_RS13330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C16_RS13335	COG0512	Glutamine amidotransferase of anthranilate synthase
D9C16_RS13340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9C16_RS13345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C16_RS13350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9C16_RS13355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9C16_RS13360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9C16_RS13365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9C16_RS13370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D9C16_RS13375	COG0037	tRNA processing
D9C16_RS13385	COG2304	oxidoreductase activity
D9C16_RS13390	COG2208	phosphoserine phosphatase activity
D9C16_RS13405	COG1098	S1 RNA binding domain
D9C16_RS13410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9C16_RS13425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9C16_RS13430	COG3956	TIGRFAM MazG family protein
D9C16_RS13435	COG2244	polysaccharide biosynthetic process
D9C16_RS13440	COG2002	toxin-antitoxin pair type II binding
D9C16_RS13445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9C16_RS13455	COG0193	aminoacyl-tRNA hydrolase activity
D9C16_RS13460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9C16_RS13465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9C16_RS13470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9C16_RS13475	COG2088	sporulation resulting in formation of a cellular spore
D9C16_RS13480	COG0251	oxidation-reduction process
D9C16_RS13485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C16_RS13490	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9C16_RS13500	COG4466	Protein conserved in bacteria
D9C16_RS13510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9C16_RS13515	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D9C16_RS13520	COG3584	3D domain protein
D9C16_RS13520	COG3583	domain protein
D9C16_RS13525	COG0084	hydrolase, TatD family'
D9C16_RS13530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C16_RS13530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C16_RS13535	COG2002	toxin-antitoxin pair type II binding
D9C16_RS13540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9C16_RS13545	COG2827	Endonuclease containing a URI domain
D9C16_RS13550	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D9C16_RS13555	COG4467	Involved in initiation control of chromosome replication
D9C16_RS13560	COG1774	PSP1 C-terminal conserved region
D9C16_RS13565	COG0470	DNA polymerase III
D9C16_RS13570	COG1728	Protein conserved in bacteria
D9C16_RS13575	COG3870	Protein conserved in bacteria
D9C16_RS13580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9C16_RS13585	COG1982	Orn Lys Arg decarboxylase major
D9C16_RS13590	COG3853	Toxic anion resistance protein (TelA)
D9C16_RS13595	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D9C16_RS13640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9C16_RS13645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9C16_RS13650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9C16_RS13660	COG0590	tRNA wobble adenosine to inosine editing
D9C16_RS13665	COG1335	isochorismatase
D9C16_RS13670	COG3858	chitin binding
D9C16_RS13670	COG1388	LysM domain
D9C16_RS13675	COG1428	Deoxynucleoside kinase
D9C16_RS13680	COG1428	Deoxynucleoside kinase
D9C16_RS13690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9C16_RS13695	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D9C16_RS13700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D9C16_RS13705	COG1686	Belongs to the peptidase S11 family
D9C16_RS13710	COG0517	IMP dehydrogenase activity
D9C16_RS13710	COG0516	GMP reductase activity
D9C16_RS13745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9C16_RS13750	COG0187	DNA topoisomerase II activity
D9C16_RS13760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9C16_RS13765	COG2501	S4 domain
D9C16_RS13770	COG0592	DNA-directed DNA polymerase activity
D9C16_RS13775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9C16_RS13785	COG0594	ribonuclease P activity
D9C16_RS13790	COG0706	membrane insertase activity
D9C16_RS13795	COG1847	R3H domain protein
D9C16_RS13800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9C16_RS13805	COG0445	tRNA wobble uridine modification
D9C16_RS13810	COG0357	Ribosomal RNA small subunit methyltransferase G
D9C16_RS13815	COG1475	DNA binding
D9C16_RS13825	COG1192	Involved in chromosome partitioning
D9C16_RS13830	COG1475	DNA binding
D9C16_RS13840	COG3949	Membrane
D9C16_RS13845	COG4481	Protein conserved in bacteria
D9C16_RS13850	COG0243	molybdopterin cofactor binding
D9C16_RS13855	COG0012	GTP binding
D9C16_RS13860	COG0360	Binds together with S18 to 16S ribosomal RNA
D9C16_RS13865	COG0629	single-stranded DNA binding
D9C16_RS13870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9C16_RS13875	COG0708	Exodeoxyribonuclease III
D9C16_RS13890	COG0542	response to heat
D9C16_RS13895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C16_RS13900	COG0346	lactoylglutathione lyase activity
D9C16_RS13905	COG2814	Major facilitator Superfamily
D9C16_RS13905	COG0477	Major facilitator Superfamily
D9C16_RS13910	COG1266	CAAX protease self-immunity
D9C16_RS13915	COG1331	Highly conserved protein containing a thioredoxin domain
D9C16_RS13920	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D9C16_RS13925	COG1331	Highly conserved protein containing a thioredoxin domain
D9C16_RS13930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C16_RS13935	COG2315	Protein conserved in bacteria
D9C16_RS13940	COG0456	acetyltransferase
D9C16_RS13945	COG2364	Membrane
D9C16_RS13950	COG2153	protein acetylation
D9C16_RS13960	COG1846	Transcriptional regulator
D9C16_RS13975	COG1357	PFAM Pentapeptide repeats (8 copies)
D9C16_RS13980	COG4319	ketosteroid isomerase
D9C16_RS13990	COG4978	Transcriptional regulator
D9C16_RS13990	COG0789	Transcriptional regulator
D9C16_RS13995	COG2271	Major facilitator Superfamily
D9C16_RS14010	COG1227	inorganic diphosphatase activity
D9C16_RS14015	COG1733	regulation of RNA biosynthetic process
D9C16_RS14030	COG4241	membrane
D9C16_RS14035	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D9C16_RS14040	COG0359	binds to the 23S rRNA
D9C16_RS14045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D9C16_RS14050	COG2807	transmembrane transport
D9C16_RS14055	COG3093	addiction module antidote protein HigA
D9C16_RS14070	COG0305	Participates in initiation and elongation during chromosome replication
D9C16_RS14075	COG0346	lactoylglutathione lyase activity
D9C16_RS14105	COG0745	RESPONSE REGULATOR receiver
D9C16_RS14110	COG5002	protein histidine kinase activity
D9C16_RS14115	COG4863	YycH protein
D9C16_RS14120	COG4853	Protein conserved in bacteria
D9C16_RS14125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9C16_RS14130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C16_RS14145	COG3829	transcription factor binding
D9C16_RS14150	COG0640	Transcriptional regulator
D9C16_RS14155	COG5658	integral membrane protein
D9C16_RS14175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9C16_RS14180	COG0833	amino acid
D9C16_RS14185	COG0010	Belongs to the arginase family
D9C16_RS14195	COG0457	Tetratricopeptide repeat
D9C16_RS14200	COG0456	acetyltransferase
D9C16_RS14205	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
D9C16_RS14225	COG1063	alcohol dehydrogenase
D9C16_RS14240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9C16_RS14280	COG2963	transposase activity
D9C16_RS14310	COG0210	DNA helicase
D9C16_RS14345	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C16_RS14360	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D9C16_RS14365	COG1131	(ABC) transporter
D9C16_RS14375	COG2188	Transcriptional regulator
D9C16_RS14390	COG2723	6-phospho-beta-galactosidase activity
D9C16_RS14395	COG3634	alkyl hydroperoxide reductase activity
D9C16_RS14400	COG0450	alkyl hydroperoxide reductase
D9C16_RS14405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9C16_RS14410	COG2610	gluconate transmembrane transporter activity
D9C16_RS14415	COG1070	Carbohydrate kinase
D9C16_RS14420	COG1802	Transcriptional regulator
D9C16_RS14425	COG1929	Belongs to the glycerate kinase type-1 family
D9C16_RS14430	COG5039	Polysaccharide pyruvyl transferase
D9C16_RS14435	COG1346	cytolysis
D9C16_RS14440	COG1380	Effector of murein hydrolase LrgA
D9C16_RS14445	COG1846	Transcriptional regulator
D9C16_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS14455	COG1309	transcriptional regulator
D9C16_RS14460	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS14525	COG0326	Molecular chaperone. Has ATPase activity
D9C16_RS14555	COG0667	Aldo Keto reductase
D9C16_RS14560	COG1349	DNA-binding transcription factor activity
D9C16_RS14580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C16_RS14585	COG3962	Belongs to the TPP enzyme family
D9C16_RS14590	COG1082	Xylose isomerase domain protein TIM barrel
D9C16_RS14595	COG2814	Major facilitator Superfamily
D9C16_RS14600	COG0673	inositol 2-dehydrogenase activity
D9C16_RS14605	COG1082	Xylose isomerase domain protein TIM barrel
D9C16_RS14610	COG1082	Xylose isomerase domain protein TIM barrel
D9C16_RS14615	COG0191	fructose-bisphosphate aldolase activity
D9C16_RS14620	COG0745	RESPONSE REGULATOR receiver
D9C16_RS14625	COG2205	protein histidine kinase activity
D9C16_RS14640	COG5294	Protein conserved in bacteria
D9C16_RS14645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS14675	COG0561	phosphatase activity
D9C16_RS14680	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D9C16_RS14685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C16_RS14690	COG0456	acetyltransferase
D9C16_RS14695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C16_RS14700	COG0765	amino acid transport
D9C16_RS14705	COG1126	abc transporter atp-binding protein
D9C16_RS14710	COG1473	amidohydrolase
D9C16_RS14720	COG3192	ethanolamine utilization protein
D9C16_RS14730	COG2390	Transcriptional regulator
D9C16_RS14735	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9C16_RS14740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C16_RS14745	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D9C16_RS14760	COG3507	Belongs to the glycosyl hydrolase 43 family
D9C16_RS14765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D9C16_RS14770	COG0494	nUDIX hydrolase
D9C16_RS14790	COG5444	nuclease activity
D9C16_RS14810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS14810	COG1263	PTS System
D9C16_RS14810	COG2190	(PTS) system
D9C16_RS14820	COG0589	response to stress
D9C16_RS14835	COG0697	spore germination
D9C16_RS14955	COG2755	lipolytic protein G-D-S-L family
D9C16_RS14955	COG3401	FG-GAP repeat protein
D9C16_RS14960	COG0513	Belongs to the DEAD box helicase family
D9C16_RS14965	COG2270	Major facilitator Superfamily
D9C16_RS14975	COG3711	transcriptional antiterminator
D9C16_RS14980	COG2273	Hydrolase Family 16
D9C16_RS14985	COG2851	Citrate transporter
D9C16_RS14990	COG0753	catalase activity
D9C16_RS14990	COG0693	protein deglycase activity
D9C16_RS15005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C16_RS15010	COG0500	methyltransferase
D9C16_RS15015	COG2610	gluconate transmembrane transporter activity
D9C16_RS15020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9C16_RS15025	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9C16_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS15035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C16_RS15040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C16_RS15045	COG4894	glucomannan catabolic process
D9C16_RS15055	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9C16_RS15060	COG2197	response regulator
D9C16_RS15065	COG4585	Histidine kinase
D9C16_RS15075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9C16_RS15085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS15090	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS15095	COG2508	Transcriptional regulator
D9C16_RS15100	COG3842	ATPase activity
D9C16_RS15105	COG0726	polysaccharide deacetylase
D9C16_RS15115	COG0501	Belongs to the peptidase M48B family
D9C16_RS15120	COG3493	citrate carrier protein
D9C16_RS15125	COG1271	oxidase subunit
D9C16_RS15130	COG1294	oxidase, subunit
D9C16_RS15135	COG4988	ABC transporter
D9C16_RS15140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D9C16_RS15145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9C16_RS15150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D9C16_RS15155	COG1595	DNA-templated transcription, initiation
D9C16_RS15175	COG1131	(ABC) transporter
D9C16_RS15180	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C16_RS15185	COG2814	Major facilitator Superfamily
D9C16_RS15190	COG0753	catalase activity
D9C16_RS15195	COG2094	Belongs to the DNA glycosylase MPG family
D9C16_RS15205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS15205	COG3711	transcriptional antiterminator
D9C16_RS15210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C16_RS15215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C16_RS15220	COG1447	Phosphotransferase system cellobiose-specific component IIA
D9C16_RS15225	COG1486	melibiose metabolic process
D9C16_RS15230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C16_RS15240	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D9C16_RS15245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9C16_RS15250	COG1696	Membrane protein involved in D-alanine export
D9C16_RS15255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS15275	COG1575	Belongs to the MenA family. Type 1 subfamily
D9C16_RS15285	COG2357	RelA SpoT domain protein
D9C16_RS15290	COG2234	aminopeptidase activity
D9C16_RS15295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9C16_RS15300	COG1846	Transcriptional regulator
D9C16_RS15305	COG5522	Integral membrane protein (intg_mem_TP0381)
D9C16_RS15310	COG1442	glycosyl transferase family 8
D9C16_RS15315	COG3711	transcriptional antiterminator
D9C16_RS15320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS15320	COG1263	PTS System
D9C16_RS15330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C16_RS15340	COG0346	lactoylglutathione lyase activity
D9C16_RS15345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9C16_RS15350	COG4895	conserved protein (DUF2196)
D9C16_RS15355	COG2814	Major facilitator Superfamily
D9C16_RS15360	COG1346	cytolysis
D9C16_RS15365	COG1380	Effector of murein hydrolase LrgA
D9C16_RS15370	COG0583	DNA-binding transcription factor activity
D9C16_RS15375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D9C16_RS15380	COG0352	thiamine-phosphate diphosphorylase activity
D9C16_RS15385	COG0672	)-iron permease
D9C16_RS15390	COG2822	iron ion transport
D9C16_RS15395	COG2837	iron assimilation
D9C16_RS15400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9C16_RS15405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C16_RS15410	COG3162	membrane
D9C16_RS15420	COG1309	transcriptional regulator
D9C16_RS15425	COG2246	polysaccharide biosynthetic process
D9C16_RS15430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D9C16_RS15435	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D9C16_RS15440	COG2261	transglycosylase associated protein
D9C16_RS15445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9C16_RS15450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9C16_RS15455	COG1845	cytochrome c oxidase, subunit III
D9C16_RS15460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9C16_RS15475	COG0772	Belongs to the SEDS family
D9C16_RS15480	COG0778	Nitroreductase
D9C16_RS15490	COG1404	Belongs to the peptidase S8 family
D9C16_RS15505	COG2116	formate transmembrane transporter activity
D9C16_RS15510	COG1263	PTS System
D9C16_RS15510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C16_RS15515	COG1621	beta-fructofuranosidase activity
D9C16_RS15525	COG0351	phosphomethylpyrimidine kinase
D9C16_RS15530	COG1216	Glycosyl transferase, family 2
D9C16_RS15535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9C16_RS15540	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS15550	COG2233	PERMEase
D9C16_RS15555	COG2363	Small membrane protein
D9C16_RS15570	COG0463	Glycosyl transferase, family 2
D9C16_RS15575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C16_RS15580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C16_RS15585	COG0456	acetyltransferase
D9C16_RS15590	COG2089	acid synthase
D9C16_RS15595	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9C16_RS15600	COG3980	spore coat polysaccharide biosynthesis protein
D9C16_RS15605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D9C16_RS15610	COG1088	dTDP-glucose 4,6-dehydratase activity
D9C16_RS15615	COG1091	dTDP-4-dehydrorhamnose reductase activity
D9C16_RS15620	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D9C16_RS15630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C16_RS15635	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS15640	COG4187	Peptidase family M20/M25/M40
D9C16_RS15645	COG0833	amino acid
D9C16_RS15650	COG2814	Major facilitator Superfamily
D9C16_RS15655	COG0077	Prephenate dehydratase
D9C16_RS15660	COG1917	Cupin 2, conserved barrel domain protein
D9C16_RS15665	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS15670	COG0151	Belongs to the GarS family
D9C16_RS15675	COG2814	Major facilitator Superfamily
D9C16_RS15680	COG0436	Aminotransferase
D9C16_RS15685	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS15690	COG3253	May function as heme-dependent peroxidase
D9C16_RS15695	COG0280	phosphate acetyltransferase
D9C16_RS15700	COG0583	DNA-binding transcription factor activity
D9C16_RS15705	COG0095	Lipoate-protein ligase
D9C16_RS15710	COG0697	spore germination
D9C16_RS15720	COG4844	belongs to the
D9C16_RS15725	COG1078	dGTPase activity
D9C16_RS15730	COG3465	dGTPase activity
D9C16_RS15735	COG1959	2 iron, 2 sulfur cluster binding
D9C16_RS15740	COG0477	Major facilitator Superfamily
D9C16_RS15750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9C16_RS15755	COG1846	Transcriptional regulator
D9C16_RS15760	COG1942	4-Oxalocrotonate Tautomerase
D9C16_RS15765	COG1994	Peptidase M50
D9C16_RS15780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C16_RS15785	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9C16_RS15790	COG0010	Belongs to the arginase family
D9C16_RS15795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9C16_RS15805	COG0457	Tetratricopeptide repeat
D9C16_RS15815	COG3391	amine dehydrogenase activity
D9C16_RS15820	COG3391	amine dehydrogenase activity
D9C16_RS15830	COG0612	Peptidase, M16
D9C16_RS15835	COG0612	Peptidase, M16
D9C16_RS15840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9C16_RS15845	COG1131	(ABC) transporter
D9C16_RS15855	COG0535	radical SAM domain protein
D9C16_RS15870	COG4506	Protein conserved in bacteria
D9C16_RS15875	COG0018	arginyl-trna synthetase
D9C16_RS15880	COG2223	nitrite transmembrane transporter activity
D9C16_RS15885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9C16_RS15895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9C16_RS15905	COG1140	nitrate reductase beta subunit
D9C16_RS15910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D9C16_RS15915	COG2181	nitrate reductase activity
D9C16_RS15925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C16_RS15935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C16_RS15945	COG4294	response to UV
D9C16_RS15950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C16_RS15955	COG0247	lactate metabolic process
D9C16_RS15955	COG2181	nitrate reductase activity
D9C16_RS15960	COG1960	acyl-CoA dehydrogenase activity
D9C16_RS15965	COG3343	RNA polymerase activity
D9C16_RS15970	COG0504	CTP synthase activity
D9C16_RS15975	COG4821	SIS domain
D9C16_RS15980	COG2204	response regulator
D9C16_RS15985	COG0191	fructose-bisphosphate aldolase activity
D9C16_RS15990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D9C16_RS15995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9C16_RS16000	COG1494	fructose-1,6-bisphosphatase
D9C16_RS16010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9C16_RS16020	COG1435	thymidine kinase activity
D9C16_RS16025	COG0281	malic enzyme
D9C16_RS16030	COG0679	Auxin Efflux Carrier
D9C16_RS16035	COG0789	Transcriptional regulator
D9C16_RS16040	COG0346	lactoylglutathione lyase activity
D9C16_RS16045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9C16_RS16050	COG2890	protein-(glutamine-N5) methyltransferase activity
D9C16_RS16070	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9C16_RS16075	COG0009	L-threonylcarbamoyladenylate synthase
D9C16_RS16080	COG1971	Probably functions as a manganese efflux pump
D9C16_RS16085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9C16_RS16090	COG0698	ribose 5-phosphate isomerase
D9C16_RS16095	COG4475	Protein of unknown function (DUF436)
D9C16_RS16100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9C16_RS16105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9C16_RS16115	COG0356	it plays a direct role in the translocation of protons across the membrane
D9C16_RS16125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9C16_RS16130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9C16_RS16135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9C16_RS16140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9C16_RS16145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9C16_RS16150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9C16_RS16160	COG4836	Membrane
D9C16_RS16170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9C16_RS16175	COG2385	sporulation resulting in formation of a cellular spore
D9C16_RS16180	COG2304	oxidoreductase activity
D9C16_RS16190	COG2304	oxidoreductase activity
D9C16_RS16200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9C16_RS16205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9C16_RS16215	COG0457	Tetratricopeptide repeat
D9C16_RS16220	COG1994	Peptidase M50
D9C16_RS16225	COG3237	CsbD-like
D9C16_RS16240	COG0831	urea catabolic process
D9C16_RS16245	COG0832	Belongs to the urease beta subunit family
D9C16_RS16250	COG0804	urea catabolic process
D9C16_RS16255	COG1959	2 iron, 2 sulfur cluster binding
D9C16_RS16260	COG2910	NAD(P)H-binding
D9C16_RS16270	COG0789	Transcriptional regulator
D9C16_RS16275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C16_RS16285	COG2089	acid synthase
D9C16_RS16295	COG1247	-acetyltransferase
D9C16_RS16300	COG0739	heme binding
D9C16_RS16310	COG0671	phosphoesterase, PA-phosphatase related
D9C16_RS16315	COG0347	Belongs to the P(II) protein family
D9C16_RS16320	COG0004	ammonium transporteR
D9C16_RS16330	COG1335	isochorismatase
D9C16_RS16335	COG0477	Major facilitator Superfamily
D9C16_RS16340	COG1953	Uracil, thiamine, allantoin
D9C16_RS16345	COG3420	alginic acid biosynthetic process
D9C16_RS16350	COG2814	Major facilitator Superfamily
D9C16_RS16355	COG1846	Transcriptional regulator
D9C16_RS16365	COG1609	Transcriptional regulator
D9C16_RS16370	COG1077	Cell shape determining protein MreB Mrl
D9C16_RS16375	COG4786	Flagellar basal body rod
D9C16_RS16380	COG4786	Flagellar basal body rod
D9C16_RS16385	COG0457	Tetratricopeptide repeat
D9C16_RS16390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9C16_RS16395	COG1970	mechanosensitive ion channel activity
D9C16_RS16400	COG0745	RESPONSE REGULATOR receiver
D9C16_RS16400	COG2972	Histidine kinase
D9C16_RS16410	COG3764	Sortase (surface protein transpeptidase)
D9C16_RS16425	COG0629	single-stranded DNA binding
D9C16_RS16430	COG1349	DNA-binding transcription factor activity
D9C16_RS16435	COG0561	phosphatase activity
D9C16_RS16445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9C16_RS16450	COG4715	Zinc finger, swim domain protein
D9C16_RS16460	COG3944	biosynthesis protein
D9C16_RS16465	COG0489	protein tyrosine kinase activity
D9C16_RS16470	COG4464	protein tyrosine phosphatase activity
D9C16_RS16475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C16_RS16500	COG5444	nuclease activity
D9C16_RS16530	COG0583	DNA-binding transcription factor activity
D9C16_RS16535	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9C16_RS16545	COG2059	Chromate
D9C16_RS16550	COG2059	Chromate
D9C16_RS16555	COG1522	sequence-specific DNA binding
D9C16_RS16560	COG0405	Gamma-glutamyltransferase
D9C16_RS16570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9C16_RS16580	COG5337	Spore coat protein CotH
D9C16_RS16595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9C16_RS16600	COG0583	DNA-binding transcription factor activity
D9C16_RS16605	COG0028	Belongs to the TPP enzyme family
D9C16_RS16610	COG3527	Alpha-acetolactate decarboxylase
D9C16_RS16615	COG2249	NAD(P)H dehydrogenase (quinone) activity
D9C16_RS16625	COG3103	Sh3 type 3 domain protein
D9C16_RS16630	COG1879	ABC-type sugar transport system periplasmic component
D9C16_RS16635	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9C16_RS16640	COG1129	ABC transporter
D9C16_RS16645	COG1869	D-ribose catabolic process
D9C16_RS16650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C16_RS16655	COG1609	Transcriptional regulator
D9C16_RS16665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9C16_RS16675	COG2843	Capsule synthesis protein
D9C16_RS16685	COG0791	NLP P60 protein
D9C16_RS16690	COG0561	phosphatase activity
D9C16_RS16695	COG1316	TRANSCRIPTIONal
D9C16_RS16710	COG0814	amino acid
D9C16_RS16715	COG0697	spore germination
D9C16_RS16720	COG1482	cell wall glycoprotein biosynthetic process
D9C16_RS16725	COG4193	domain, Protein
D9C16_RS16730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C16_RS16735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9C16_RS16740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9C16_RS16745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C16_RS16750	COG0463	Glycosyl transferase, family 2
D9C16_RS16750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C16_RS16765	COG1682	transport, permease protein
D9C16_RS16770	COG1134	teichoic acid transport
D9C16_RS16780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C16_RS16785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D9C16_RS16795	COG1950	PFAM Membrane protein of
D9C16_RS16800	COG1983	PspC domain protein
D9C16_RS16805	COG3595	metallopeptidase activity
D9C16_RS16820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C16_RS16825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9C16_RS16830	COG0556	nucleotide-excision repair
D9C16_RS16835	COG4897	Protein conserved in bacteria
D9C16_RS16840	COG0574	Belongs to the PEP-utilizing enzyme family
D9C16_RS16840	COG3848	Pyruvate phosphate dikinase
D9C16_RS16845	COG1309	transcriptional regulator
D9C16_RS16850	COG2814	Major facilitator Superfamily
D9C16_RS16855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C16_RS16865	COG0793	Belongs to the peptidase S41A family
D9C16_RS16865	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS16870	COG2177	Part of the ABC transporter FtsEX involved in
D9C16_RS16875	COG2884	Cell division ATP-binding protein ftsE
D9C16_RS16880	COG2010	Cytochrome c
D9C16_RS16885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C16_RS16900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9C16_RS16915	COG1516	flagellar protein fliS
D9C16_RS16920	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9C16_RS16925	COG1334	flagellar protein FlaG
D9C16_RS16930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C16_RS16935	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9C16_RS16940	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D9C16_RS16950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C16_RS16955	COG4786	Flagellar basal body rod
D9C16_RS16955	COG1256	bacterial-type flagellum assembly
D9C16_RS16960	COG3418	PFAM FlgN family protein
D9C16_RS16965	COG2747	anti-sigma28 factor FlgM
D9C16_RS16975	COG1040	competence protein
D9C16_RS16985	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D9C16_RS16990	COG1307	EDD domain protein, DegV family
D9C16_RS16995	COG2197	response regulator
D9C16_RS17000	COG4585	Histidine kinase
D9C16_RS17005	COG1739	Uncharacterized protein family UPF0029
D9C16_RS17010	COG1316	TRANSCRIPTIONal
D9C16_RS17045	COG1131	(ABC) transporter
D9C16_RS17055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9C16_RS17060	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS17065	COG1215	transferase activity, transferring glycosyl groups
D9C16_RS17070	COG3206	protein involved in exopolysaccharide biosynthesis
D9C16_RS17075	COG3307	-O-antigen
D9C16_RS17085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C16_RS17090	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS17090	COG0297	glycogen (starch) synthase activity
D9C16_RS17095	COG2244	polysaccharide biosynthetic process
D9C16_RS17110	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS17110	COG2247	cell wall binding repeat
D9C16_RS17115	COG2247	cell wall binding repeat
D9C16_RS17115	COG2385	sporulation resulting in formation of a cellular spore
D9C16_RS17150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9C16_RS17155	COG2188	Transcriptional regulator
D9C16_RS17160	COG0363	glucosamine-6-phosphate deaminase activity
D9C16_RS17165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9C16_RS17170	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D9C16_RS17175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9C16_RS17180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D9C16_RS17185	COG0546	phosphoglycolate phosphatase activity
D9C16_RS17200	COG5297	Belongs to the glycosyl hydrolase family 6
D9C16_RS17205	COG4990	cell redox homeostasis
D9C16_RS17210	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9C16_RS17215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9C16_RS17220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9C16_RS17225	COG0131	Imidazoleglycerol-phosphate dehydratase
D9C16_RS17230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9C16_RS17235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9C16_RS17240	COG0107	imidazoleglycerol-phosphate synthase activity
D9C16_RS17245	COG0140	phosphoribosyl-ATP diphosphatase activity
D9C16_RS17245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9C16_RS17265	COG1132	(ABC) transporter
D9C16_RS17270	COG0457	Tetratricopeptide repeat
D9C16_RS17275	COG0791	NLP P60 protein
D9C16_RS17275	COG3883	PFAM NLP P60 protein
D9C16_RS17280	COG0492	ferredoxin-NADP+ reductase activity
D9C16_RS17285	COG1051	belongs to the nudix hydrolase family
D9C16_RS17290	COG1660	Displays ATPase and GTPase activities
D9C16_RS17295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D9C16_RS17300	COG1481	regulation of sporulation
D9C16_RS17305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C16_RS17310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D9C16_RS17320	COG0745	RESPONSE REGULATOR receiver
D9C16_RS17325	COG5002	protein histidine kinase activity
D9C16_RS17330	COG1136	(ABC) transporter
D9C16_RS17335	COG0577	efflux transmembrane transporter activity
D9C16_RS17345	COG0288	reversible hydration of carbon dioxide
D9C16_RS17350	COG0659	secondary active sulfate transmembrane transporter activity
D9C16_RS17360	COG1611	Belongs to the LOG family
D9C16_RS17365	COG1609	Transcriptional regulator
D9C16_RS17375	COG2182	Extracellular solute-binding protein
D9C16_RS17380	COG1175	transmembrane transport
D9C16_RS17385	COG3833	ABC-type maltose transport systems, permease component
D9C16_RS17390	COG5521	maltodextrose utilization protein MalA
D9C16_RS17395	COG1554	hydrolase, family 65, central catalytic
D9C16_RS17400	COG0366	Alpha amylase catalytic
D9C16_RS17405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9C16_RS17410	COG0740	serine-type endopeptidase activity
D9C16_RS17420	COG4974	Belongs to the 'phage' integrase family
D9C16_RS17520	COG0582	viral genome integration into host DNA
D9C16_RS17600	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C16_RS17635	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS17635	COG1388	LysM domain
D9C16_RS17635	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS17655	COG1674	ftsk spoiiie
D9C16_RS17675	COG2076	Multidrug Resistance protein
D9C16_RS17680	COG2076	Multidrug Resistance protein
D9C16_RS17685	COG1309	transcriptional regulator
D9C16_RS17690	COG0531	amino acid
D9C16_RS17695	COG1621	beta-fructofuranosidase activity
D9C16_RS17700	COG1621	beta-fructofuranosidase activity
D9C16_RS17710	COG1794	racemase activity, acting on amino acids and derivatives
D9C16_RS17725	COG3479	Phenolic acid decarboxylase
D9C16_RS17735	COG2272	Belongs to the type-B carboxylesterase lipase family
D9C16_RS17740	COG1396	sequence-specific DNA binding
D9C16_RS17745	COG3944	biosynthesis protein
D9C16_RS17750	COG0489	protein tyrosine kinase activity
D9C16_RS17755	COG1086	Polysaccharide biosynthesis protein
D9C16_RS17760	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS17765	COG1215	transferase activity, transferring glycosyl groups
D9C16_RS17770	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS17780	COG1216	Glycosyl transferase, family 2
D9C16_RS17785	COG5039	Polysaccharide pyruvyl transferase
D9C16_RS17790	COG1216	Glycosyl transferase, family 2
D9C16_RS17795	COG2244	polysaccharide biosynthetic process
D9C16_RS17800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9C16_RS17805	COG0110	maltose O-acetyltransferase activity
D9C16_RS17810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C16_RS17815	COG5039	Polysaccharide pyruvyl transferase
D9C16_RS17825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9C16_RS17830	COG1620	l-lactate permease
D9C16_RS17835	COG2186	Transcriptional regulator
D9C16_RS17840	COG1609	Transcriptional regulator
D9C16_RS17845	COG2182	Extracellular solute-binding protein
D9C16_RS17850	COG1175	transmembrane transport
D9C16_RS17855	COG3833	ABC-type maltose transport systems, permease component
D9C16_RS17860	COG1874	Beta-galactosidase
D9C16_RS17865	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D9C16_RS17870	COG2208	phosphoserine phosphatase activity
D9C16_RS17875	COG0596	Alpha beta hydrolase
D9C16_RS17895	COG1131	(ABC) transporter
D9C16_RS17900	COG0842	Transport permease protein
D9C16_RS17905	COG4585	Histidine kinase
D9C16_RS17910	COG2197	response regulator
D9C16_RS17915	COG0247	lactate metabolic process
D9C16_RS17920	COG1139	Iron-sulfur cluster binding protein
D9C16_RS17925	COG1556	Lactate utilization protein
D9C16_RS17935	COG1113	amino acid transport
D9C16_RS17940	COG0697	spore germination
D9C16_RS17945	COG0583	DNA-binding transcription factor activity
D9C16_RS17955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C16_RS17960	COG1609	Transcriptional regulator
D9C16_RS17965	COG2814	Major facilitator Superfamily
D9C16_RS17970	COG2390	Transcriptional regulator
D9C16_RS17975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9C16_RS17980	COG0126	phosphoglycerate kinase activity
D9C16_RS17985	COG0149	triose-phosphate isomerase activity
D9C16_RS17990	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9C16_RS17995	COG0148	phosphopyruvate hydratase activity
D9C16_RS18000	COG0456	acetyltransferase
D9C16_RS18005	COG4640	response to antibiotic
D9C16_RS18010	COG3064	Membrane
D9C16_RS18020	COG2095	MarC family integral membrane protein
D9C16_RS18025	COG1510	regulation of RNA biosynthetic process
D9C16_RS18030	COG0517	IMP dehydrogenase activity
D9C16_RS18030	COG1125	glycine betaine transport
D9C16_RS18035	COG1174	glycine betaine transport
D9C16_RS18040	COG1732	Glycine betaine
D9C16_RS18045	COG1174	glycine betaine transport
D9C16_RS18050	COG1510	regulation of RNA biosynthetic process
D9C16_RS18055	COG1125	glycine betaine transport
D9C16_RS18055	COG0517	IMP dehydrogenase activity
D9C16_RS18060	COG1174	glycine betaine transport
D9C16_RS18065	COG1732	Glycine betaine
D9C16_RS18070	COG1174	glycine betaine transport
D9C16_RS18075	COG0840	transmembrane signaling receptor activity
D9C16_RS18080	COG1733	regulation of RNA biosynthetic process
D9C16_RS18085	COG1396	sequence-specific DNA binding
D9C16_RS18090	COG1396	sequence-specific DNA binding
D9C16_RS18095	COG1476	TRANSCRIPTIONal
D9C16_RS18100	COG0596	Alpha beta hydrolase
D9C16_RS18105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9C16_RS18110	COG1647	Serine aminopeptidase, S33
D9C16_RS18115	COG0557	exoribonuclease II activity
D9C16_RS18120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9C16_RS18345	COG3942	CHAP domain
D9C16_RS18345	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C16_RS18370	COG4824	toxin secretion phage lysis holin
D9C16_RS18375	COG3409	Peptidoglycan-binding domain 1 protein
D9C16_RS18375	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS18390	COG5444	nuclease activity
D9C16_RS18400	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS18405	COG1309	transcriptional regulator
D9C16_RS18410	COG2076	Multidrug Resistance protein
D9C16_RS18420	COG1289	transmembrane transporter activity
D9C16_RS18435	COG0673	inositol 2-dehydrogenase activity
D9C16_RS18440	COG1937	Protein conserved in bacteria
D9C16_RS18445	COG2608	mercury ion transmembrane transporter activity
D9C16_RS18450	COG2217	Heavy metal translocating P-type atpase
D9C16_RS18455	COG2217	Heavy metal translocating P-type atpase
D9C16_RS18460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9C16_RS18465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D9C16_RS18470	COG2860	membrane
D9C16_RS18480	COG3973	AAA domain
D9C16_RS18485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9C16_RS18490	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C16_RS18495	COG0025	NhaP-type Na H and K H
D9C16_RS18505	COG0656	L-ascorbic acid biosynthetic process
D9C16_RS18510	COG4149	molybdate abc transporter
D9C16_RS18515	COG0725	ABC transporter, periplasmic molybdate-binding protein
D9C16_RS18520	COG1910	domain protein
D9C16_RS18525	COG1368	sulfuric ester hydrolase activity
D9C16_RS18530	COG1988	membrane-bound metal-dependent
D9C16_RS18545	COG0531	amino acid
D9C16_RS18555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS18560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS18570	COG1120	ATPase activity
D9C16_RS18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9C16_RS18580	COG1136	(ABC) transporter
D9C16_RS18585	COG0577	efflux transmembrane transporter activity
D9C16_RS18595	COG2140	Oxalate decarboxylase
D9C16_RS18615	COG0745	RESPONSE REGULATOR receiver
D9C16_RS18620	COG2205	protein histidine kinase activity
D9C16_RS18625	COG3386	PFAM SMP-30 Gluconolaconase
D9C16_RS18630	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS18635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C16_RS18640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C16_RS18645	COG1120	ATPase activity
D9C16_RS18650	COG2096	Adenosyltransferase
D9C16_RS18655	COG2814	Major facilitator Superfamily
D9C16_RS18660	COG4758	membrane
D9C16_RS18665	COG1842	Phage shock protein A
D9C16_RS18670	COG3595	metallopeptidase activity
D9C16_RS18675	COG4758	membrane
D9C16_RS18680	COG4585	Histidine kinase
D9C16_RS18685	COG2197	response regulator
D9C16_RS18695	COG0814	amino acid
D9C16_RS18700	COG0697	spore germination
D9C16_RS18710	COG0114	fumarate hydratase activity
D9C16_RS18715	COG1309	transcriptional regulator
D9C16_RS18725	COG2770	Histidine kinase
D9C16_RS18725	COG2205	protein histidine kinase activity
D9C16_RS18730	COG0745	RESPONSE REGULATOR receiver
D9C16_RS18735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C16_RS18740	COG0783	Belongs to the Dps family
D9C16_RS18790	COG1131	(ABC) transporter
D9C16_RS18810	COG1120	ATPase activity
D9C16_RS18820	COG0583	DNA-binding transcription factor activity
D9C16_RS18825	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS18830	COG1942	4-Oxalocrotonate Tautomerase
D9C16_RS18835	COG0477	Major facilitator Superfamily
D9C16_RS18840	COG1846	Transcriptional regulator
D9C16_RS18845	COG5577	PFAM Coat F domain
D9C16_RS18865	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9C16_RS18865	COG1024	Enoyl-CoA hydratase
D9C16_RS18870	COG0183	Belongs to the thiolase family
D9C16_RS18875	COG1960	acyl-CoA dehydrogenase activity
D9C16_RS18880	COG1393	Belongs to the ArsC family
D9C16_RS18885	COG0509	glycine decarboxylation via glycine cleavage system
D9C16_RS18895	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D9C16_RS18900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS18910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9C16_RS18915	COG2011	ABC-type metal ion transport system permease component
D9C16_RS18920	COG1464	Belongs to the NlpA lipoprotein family
D9C16_RS18940	COG0396	ATPase activity
D9C16_RS18945	COG0719	Fe-S assembly protein
D9C16_RS18950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9C16_RS18955	COG0822	iron-sulfur transferase activity
D9C16_RS18960	COG0719	Fe-S assembly protein
D9C16_RS18965	COG0640	Transcriptional regulator
D9C16_RS18970	COG0346	lactoylglutathione lyase activity
D9C16_RS18985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9C16_RS18990	COG0322	excinuclease ABC activity
D9C16_RS18995	COG2222	sugar isomerase
D9C16_RS19005	COG1175	transmembrane transport
D9C16_RS19015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C16_RS19020	COG2188	Transcriptional regulator
D9C16_RS19025	COG3842	ATPase activity
D9C16_RS19030	COG2356	endonuclease I
D9C16_RS19040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C16_RS19045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D9C16_RS19050	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9C16_RS19055	COG2068	MobA-Related Protein
D9C16_RS19060	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9C16_RS19065	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9C16_RS19070	COG2080	2 iron, 2 sulfur cluster binding
D9C16_RS19080	COG2351	hydroxyisourate hydrolase activity
D9C16_RS19085	COG3195	allantoin biosynthetic process
D9C16_RS19085	COG3648	Uricase
D9C16_RS19090	COG2233	PERMEase
D9C16_RS19095	COG2233	PERMEase
D9C16_RS19100	COG2508	Transcriptional regulator
D9C16_RS19105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9C16_RS19115	COG1801	Protein of unknown function DUF72
D9C16_RS19120	COG0730	response to heat
D9C16_RS19125	COG0737	Belongs to the 5'-nucleotidase family
D9C16_RS19130	COG3377	Domain of unknown function (DUF1805)
D9C16_RS19140	COG0739	heme binding
D9C16_RS19145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9C16_RS19155	COG4470	Protein conserved in bacteria
D9C16_RS19160	COG2445	Protein of unknown function DUF86
D9C16_RS19165	COG0647	UMP catabolic process
D9C16_RS19170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9C16_RS19175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C16_RS19180	COG0460	homoserine dehydrogenase
D9C16_RS19185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9C16_RS19190	COG0083	homoserine kinase activity
D9C16_RS19195	COG0823	Involved in the tonB-independent uptake of proteins
D9C16_RS19195	COG1506	peptidase
D9C16_RS19195	COG4946	Tricorn protease homolog
D9C16_RS19200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9C16_RS19205	COG4837	Protein of unknown function (DUF1462)
D9C16_RS19210	COG1252	NADH dehydrogenase
D9C16_RS19215	COG4844	belongs to the
D9C16_RS19220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C16_RS19225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9C16_RS19230	COG0316	Belongs to the HesB IscA family
D9C16_RS19235	COG4974	Belongs to the 'phage' integrase family
D9C16_RS19245	COG0582	viral genome integration into host DNA
D9C16_RS19345	COG0456	acetyltransferase
D9C16_RS19350	COG2808	Putative FMN-binding domain
D9C16_RS19355	COG0516	GMP reductase activity
D9C16_RS19365	COG0492	ferredoxin-NADP+ reductase activity
D9C16_RS19370	COG1252	NADH dehydrogenase
D9C16_RS19385	COG3584	3D domain protein
D9C16_RS19390	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D9C16_RS19395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9C16_RS19400	COG2056	Na+-H+ antiporter family
D9C16_RS19405	COG1268	BioY protein
D9C16_RS19410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9C16_RS19415	COG2819	hydrolase of the alpha beta superfamily
D9C16_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS19425	COG1169	isochorismate synthase
D9C16_RS19430	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9C16_RS19435	COG1535	isochorismatase
D9C16_RS19435	COG3433	isochorismatase activity
D9C16_RS19440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C16_RS19445	COG3251	PFAM MbtH domain protein
D9C16_RS19450	COG5634	Uncharacterized conserved protein (DUF2278)
D9C16_RS19455	COG0686	Belongs to the AlaDH PNT family
D9C16_RS19460	COG2508	Transcriptional regulator
D9C16_RS19460	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9C16_RS19470	COG4842	Belongs to the WXG100 family
D9C16_RS19475	COG5417	Belongs to the EsaB family
D9C16_RS19480	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9C16_RS19485	COG1674	ftsk spoiiie
D9C16_RS19485	COG0433	COG0433 Predicted ATPase
D9C16_RS19490	COG1511	domain protein
D9C16_RS19500	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS19505	COG1418	mRNA catabolic process
D9C16_RS19520	COG0628	permease
D9C16_RS19535	COG5506	Protein of unknown function (DUF1694)
D9C16_RS19540	COG1335	isochorismatase
D9C16_RS19545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D9C16_RS19550	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9C16_RS19570	COG0142	geranyltranstransferase activity
D9C16_RS19580	COG4585	Histidine kinase
D9C16_RS19585	COG2197	response regulator
D9C16_RS19590	COG2050	protein possibly involved in aromatic compounds catabolism
D9C16_RS19595	COG1320	monovalent cation:proton antiporter activity
D9C16_RS19600	COG2212	antiporter activity
D9C16_RS19605	COG1863	multisubunit Na H antiporter MnhE subunit
D9C16_RS19610	COG0651	ATP synthesis coupled electron transport
D9C16_RS19615	COG1006	Multisubunit Na H antiporter MnhC subunit
D9C16_RS19620	COG2111	Na H antiporter
D9C16_RS19625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9C16_RS19625	COG2111	Na H antiporter
D9C16_RS19635	COG3493	citrate carrier protein
D9C16_RS19640	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9C16_RS19645	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9C16_RS19650	COG3845	ABC transporter
D9C16_RS19655	COG1744	ABC transporter substrate-binding protein PnrA-like
D9C16_RS19660	COG4565	transcriptional regulatory protein
D9C16_RS19665	COG3290	protein histidine kinase activity
D9C16_RS19675	COG3011	Protein conserved in bacteria
D9C16_RS19680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C16_RS19685	COG2814	Major facilitator Superfamily
D9C16_RS19695	COG5018	Exonuclease
D9C16_RS19705	COG2205	protein histidine kinase activity
D9C16_RS19710	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D9C16_RS19720	COG2267	carboxylic ester hydrolase activity
D9C16_RS19725	COG1522	sequence-specific DNA binding
D9C16_RS19730	COG0436	Aminotransferase
D9C16_RS19735	COG1098	S1 RNA binding domain
D9C16_RS19740	COG2155	Conserved Protein
D9C16_RS19745	COG1979	alcohol dehydrogenase
D9C16_RS19750	COG1979	alcohol dehydrogenase
D9C16_RS19755	COG0166	Belongs to the GPI family
D9C16_RS19770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9C16_RS19785	COG2738	Putative neutral zinc metallopeptidase
D9C16_RS19790	COG1253	flavin adenine dinucleotide binding
D9C16_RS19795	COG0366	Alpha amylase catalytic
D9C16_RS19805	COG0432	Pfam Uncharacterised protein family UPF0047
D9C16_RS19830	COG0840	transmembrane signaling receptor activity
D9C16_RS19845	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS19845	COG3347	Dehydrogenase
D9C16_RS19850	COG1349	DNA-binding transcription factor activity
D9C16_RS19855	COG1070	Carbohydrate kinase
D9C16_RS19860	COG3254	rhamnose metabolic process
D9C16_RS19865	COG4806	L-rhamnose isomerase
D9C16_RS19870	COG0673	inositol 2-dehydrogenase activity
D9C16_RS19875	COG0628	permease
D9C16_RS19880	COG1968	undecaprenyl-diphosphatase activity
D9C16_RS19890	COG5553	Cysteine dioxygenase type I
D9C16_RS19895	COG0477	Major facilitator Superfamily
D9C16_RS19900	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C16_RS19905	COG4682	membrane
D9C16_RS19910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9C16_RS19915	COG0569	domain protein
D9C16_RS19925	COG1510	regulation of RNA biosynthetic process
D9C16_RS19930	COG1012	belongs to the aldehyde dehydrogenase family
D9C16_RS19935	COG1454	alcohol dehydrogenase
D9C16_RS19945	COG2318	DinB family
D9C16_RS19950	COG1585	Membrane protein implicated in regulation of membrane protease activity
D9C16_RS19955	COG2268	Band 7 protein
D9C16_RS19960	COG1247	-acetyltransferase
D9C16_RS19965	COG3859	Proton-coupled thiamine transporter YuaJ
D9C16_RS20090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9C16_RS20095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9C16_RS20100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9C16_RS20105	COG0297	glycogen (starch) synthase activity
D9C16_RS20110	COG0058	SHG alpha-glucan phosphorylase activity
D9C16_RS20115	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D9C16_RS20120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C16_RS20125	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS20130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C16_RS20140	COG0438	transferase activity, transferring glycosyl groups
D9C16_RS20145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C16_RS20150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C16_RS20155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C16_RS20160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C16_RS20170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D9C16_RS20175	COG0596	Alpha beta hydrolase
D9C16_RS20180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9C16_RS20185	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS20190	COG4948	Mandelate Racemase Muconate Lactonizing
D9C16_RS20195	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9C16_RS20200	COG1121	(ABC) transporter
D9C16_RS20205	COG1321	iron dependent repressor
D9C16_RS20205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C16_RS20210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C16_RS20220	COG1294	oxidase, subunit
D9C16_RS20225	COG1271	oxidase subunit
D9C16_RS20230	COG0254	rRNA binding
D9C16_RS20235	COG0288	reversible hydration of carbon dioxide
D9C16_RS20240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9C16_RS20245	COG1854	S-ribosylhomocysteine lyase activity
D9C16_RS20260	COG0783	Belongs to the Dps family
D9C16_RS20265	COG4824	toxin secretion phage lysis holin
D9C16_RS20270	COG0494	nUDIX hydrolase
D9C16_RS20275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9C16_RS20280	COG1116	anion transmembrane transporter activity
D9C16_RS20285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9C16_RS20290	COG1506	peptidase
D9C16_RS20300	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D9C16_RS20305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9C16_RS20310	COG0367	asparagine synthase
D9C16_RS20315	COG1113	amino acid transport
D9C16_RS20320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9C16_RS20325	COG2267	carboxylic ester hydrolase activity
D9C16_RS20335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D9C16_RS20340	COG1242	4 iron, 4 sulfur cluster binding
D9C16_RS20355	COG1725	Transcriptional regulator
D9C16_RS20360	COG1131	(ABC) transporter
D9C16_RS20375	COG1136	(ABC) transporter
D9C16_RS20380	COG0577	efflux transmembrane transporter activity
D9C16_RS20385	COG0745	RESPONSE REGULATOR receiver
D9C16_RS20390	COG2205	protein histidine kinase activity
D9C16_RS20395	COG1136	(ABC) transporter
D9C16_RS20400	COG0577	efflux transmembrane transporter activity
D9C16_RS20405	COG2433	Pfam Transposase IS66
D9C16_RS20410	COG2814	Major facilitator Superfamily
D9C16_RS20415	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C16_RS20415	COG2202	Pas domain
D9C16_RS20425	COG0495	leucyl-tRNA aminoacylation
D9C16_RS20430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9C16_RS20435	COG1486	melibiose metabolic process
D9C16_RS20440	COG0395	ABC-type sugar transport system, permease component
D9C16_RS20445	COG1175	transmembrane transport
D9C16_RS20450	COG1653	transport
D9C16_RS20455	COG1609	Transcriptional regulator
D9C16_RS20460	COG1073	alpha beta
D9C16_RS20470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C16_RS20490	COG2124	cytochrome p450
D9C16_RS20495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C16_RS20500	COG0395	ABC-type sugar transport system, permease component
D9C16_RS20505	COG1653	transport
D9C16_RS20515	COG4209	transmembrane transport
D9C16_RS20520	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9C16_RS20525	COG1653	transport
D9C16_RS20545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9C16_RS20550	COG2081	HI0933 family
D9C16_RS20555	COG2244	polysaccharide biosynthetic process
D9C16_RS20560	COG1187	pseudouridine synthase activity
D9C16_RS20565	COG1349	DNA-binding transcription factor activity
D9C16_RS20570	COG1131	(ABC) transporter
D9C16_RS20575	COG4473	ABC transporter
D9C16_RS20580	COG2252	PERMEase
D9C16_RS20585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C16_RS20590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C16_RS20595	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9C16_RS20605	COG1597	lipid kinase activity
D9C16_RS20610	COG1523	belongs to the glycosyl hydrolase 13 family
D9C16_RS20615	COG0510	thiamine kinase activity
D9C16_RS20625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9C16_RS20630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C16_RS20635	COG0281	malic enzyme
D9C16_RS20640	COG5584	Small secreted protein
D9C16_RS20645	COG1363	Peptidase, m42
D9C16_RS20660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C16_RS20665	COG4848	Belongs to the UPF0354 family
D9C16_RS20670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C16_RS20675	COG1674	ftsk spoiiie
D9C16_RS20680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9C16_RS20685	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D9C16_RS20690	COG4980	gas vesicle protein
D9C16_RS20695	COG3118	belongs to the thioredoxin family
D9C16_RS20700	COG1605	Chorismate mutase
D9C16_RS20700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D9C16_RS20705	COG1609	Transcriptional regulator
D9C16_RS20710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9C16_RS20715	COG1360	Flagellar Motor Protein
D9C16_RS20720	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9C16_RS20725	COG0517	IMP dehydrogenase activity
D9C16_RS20730	COG0454	-acetyltransferase
D9C16_RS20735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9C16_RS20740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9C16_RS20745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9C16_RS20755	COG2203	Gaf domain
D9C16_RS20755	COG2199	diguanylate cyclase activity
D9C16_RS20760	COG1956	GAF domain-containing protein
D9C16_RS20765	COG1309	transcriptional regulator
D9C16_RS20770	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9C16_RS20775	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D9C16_RS20780	COG1114	Component of the transport system for branched-chain amino acids
D9C16_RS20785	COG1104	cysteine desulfurase activity
D9C16_RS20790	COG0301	tRNA thio-modification
D9C16_RS20800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9C16_RS20805	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D9C16_RS20810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9C16_RS20815	COG0616	signal peptide processing
D9C16_RS20820	COG1714	RDD family
D9C16_RS20830	COG3874	Sporulation protein YtfJ
D9C16_RS20835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D9C16_RS20840	COG0827	DNA restriction-modification system
D9C16_RS20850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9C16_RS20855	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9C16_RS20860	COG0137	argininosuccinate synthase activity
D9C16_RS20865	COG0165	Argininosuccinate lyase
D9C16_RS20875	COG1028	Short-chain dehydrogenase reductase Sdr
D9C16_RS20880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D9C16_RS20890	COG4109	DRTGG domain
D9C16_RS20900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D9C16_RS20920	COG0587	DNA-directed DNA polymerase activity
D9C16_RS20925	COG0281	malic enzyme
D9C16_RS20930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9C16_RS20935	COG0825	malonyl-CoA metabolic process
D9C16_RS20940	COG0205	6-phosphofructokinase activity
D9C16_RS20945	COG0469	pyruvate kinase activity
D9C16_RS20950	COG3030	protein affecting phage T7 exclusion by the F plasmid
D9C16_RS20960	COG2707	UPF0756 membrane protein
D9C16_RS20965	COG0372	Belongs to the citrate synthase family
D9C16_RS20970	COG0538	isocitrate dehydrogenase activity
D9C16_RS20975	COG0039	L-malate dehydrogenase activity
D9C16_RS20980	COG0745	RESPONSE REGULATOR receiver
D9C16_RS20985	COG5002	protein histidine kinase activity
D9C16_RS20990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C16_RS20990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C16_RS20995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9C16_RS21000	COG1971	Probably functions as a manganese efflux pump
D9C16_RS21005	COG0237	dephospho-CoA kinase activity
D9C16_RS21010	COG0656	L-ascorbic acid biosynthetic process
D9C16_RS21015	COG2814	Major facilitator Superfamily
D9C16_RS21020	COG1733	regulation of RNA biosynthetic process
D9C16_RS21025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9C16_RS21030	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9C16_RS21035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9C16_RS21040	COG3611	Membrane attachment protein
D9C16_RS21045	COG1484	DNA-dependent DNA replication
D9C16_RS21050	COG0398	Pfam SNARE associated Golgi protein
D9C16_RS21060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9C16_RS21065	COG1011	Hydrolase
D9C16_RS21070	COG3275	phosphorelay sensor kinase activity
D9C16_RS21075	COG3279	Response regulator of the LytR AlgR family
D9C16_RS21080	COG1380	Effector of murein hydrolase LrgA
D9C16_RS21085	COG1346	cytolysis
D9C16_RS21095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9C16_RS21100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9C16_RS21105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9C16_RS21110	COG3326	Membrane
D9C16_RS21120	COG1363	Peptidase, m42
D9C16_RS21130	COG2160	L-arabinose isomerase activity
D9C16_RS21135	COG1069	ribulokinase activity
D9C16_RS21140	COG0235	Class ii aldolase
D9C16_RS21145	COG0647	UMP catabolic process
D9C16_RS21150	COG0371	Dehydrogenase
D9C16_RS21155	COG1653	transport
D9C16_RS21160	COG1175	transmembrane transport
D9C16_RS21165	COG0395	ABC-type sugar transport system, permease component
D9C16_RS21170	COG3534	alpha-L-arabinofuranosidase
D9C16_RS21175	COG1966	Carbon starvation protein
D9C16_RS21180	COG0346	lactoylglutathione lyase activity
D9C16_RS21185	COG0247	lactate metabolic process
D9C16_RS21190	COG0277	FAD linked oxidase domain protein
D9C16_RS21195	COG3835	regulator
D9C16_RS21205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9C16_RS21215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9C16_RS21220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C16_RS21220	COG0072	phenylalanine-tRNA ligase activity
D9C16_RS21225	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9C16_RS21230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D9C16_RS21235	COG1286	toxin biosynthetic process
D9C16_RS21240	COG1796	DNA polymerase
D9C16_RS21240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9C16_RS21245	COG1193	negative regulation of DNA recombination
D9C16_RS21250	COG3766	membrane
D9C16_RS21255	COG0318	PFAM AMP-dependent synthetase and ligase
D9C16_RS21260	COG1309	transcriptional regulator
D9C16_RS21265	COG1024	Enoyl-CoA hydratase
D9C16_RS21270	COG2086	electron transfer activity
D9C16_RS21275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9C16_RS21280	COG3534	alpha-L-arabinofuranosidase
D9C16_RS21285	COG3118	belongs to the thioredoxin family
D9C16_RS21290	COG0322	excinuclease ABC activity
D9C16_RS21300	COG0527	aspartate kinase activity
D9C16_RS21305	COG1719	4-vinyl reductase, 4VR
D9C16_RS21310	COG2009	succinate dehydrogenase
D9C16_RS21315	COG1053	succinate dehydrogenase
D9C16_RS21320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D9C16_RS21325	COG0824	Thioesterase
D9C16_RS21330	COG2197	response regulator
D9C16_RS21335	COG1846	Transcriptional regulator
D9C16_RS21340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9C16_RS21345	COG5401	PFAM Sporulation and spore germination
D9C16_RS21350	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9C16_RS21355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9C16_RS21360	COG0622	Phosphoesterase
D9C16_RS21385	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D9C16_RS21415	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D9C16_RS21430	COG0028	Belongs to the TPP enzyme family
D9C16_RS21435	COG0440	acetolactate synthase activity
D9C16_RS21440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9C16_RS21445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9C16_RS21450	COG0473	3-isopropylmalate dehydrogenase activity
D9C16_RS21455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9C16_RS21460	COG0066	3-isopropylmalate dehydratase activity
D9C16_RS21465	COG0457	Tetratricopeptide repeat
D9C16_RS21465	COG1477	protein flavinylation
D9C16_RS21470	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9C16_RS21475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9C16_RS21480	COG0470	DNA polymerase III
D9C16_RS21480	COG1067	ATP-dependent peptidase activity
D9C16_RS21485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9C16_RS21490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9C16_RS21500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9C16_RS21505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9C16_RS21510	COG0181	hydroxymethylbilane synthase activity
D9C16_RS21515	COG1587	Uroporphyrinogen-III synthase
D9C16_RS21520	COG0113	porphobilinogen synthase activity
D9C16_RS21525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9C16_RS21530	COG1388	LysM domain
D9C16_RS21535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C16_RS21545	COG0525	valine-tRNA ligase activity
D9C16_RS21550	COG0285	dihydrofolate synthase activity
D9C16_RS21555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D9C16_RS21565	COG0424	maF-like protein
D9C16_RS21570	COG2003	Belongs to the UPF0758 family
D9C16_RS21575	COG1077	Cell shape determining protein MreB Mrl
D9C16_RS21585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D9C16_RS21590	COG0850	regulation of cytokinetic process
D9C16_RS21595	COG2894	cell division
D9C16_RS21600	COG0739	heme binding
D9C16_RS21605	COG1994	Peptidase M50
D9C16_RS21610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9C16_RS21615	COG2868	ribosomal protein
D9C16_RS21620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D9C16_RS21630	COG3290	protein histidine kinase activity
D9C16_RS21635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9C16_RS21640	COG4492	Belongs to the UPF0735 family
D9C16_RS21645	COG0077	Prephenate dehydratase
D9C16_RS21650	COG1827	regulation of RNA biosynthetic process
D9C16_RS21655	COG1104	cysteine desulfurase activity
D9C16_RS21660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9C16_RS21665	COG0157	Belongs to the NadC ModD family
D9C16_RS21670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D9C16_RS21675	COG1388	LysM domain
D9C16_RS21685	COG0217	transcriptional regulatory protein
D9C16_RS21690	COG1115	amino acid carrier protein
D9C16_RS21710	COG2112	serine threonine protein kinase
D9C16_RS21715	COG0673	inositol 2-dehydrogenase activity
D9C16_RS21720	COG2814	Major facilitator Superfamily
D9C16_RS21730	COG0632	four-way junction helicase activity
D9C16_RS21735	COG2255	four-way junction helicase activity
D9C16_RS21745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9C16_RS21750	COG0343	queuine tRNA-ribosyltransferase activity
D9C16_RS21755	COG1862	Preprotein translocase
D9C16_RS21765	COG2323	membrane
D9C16_RS21770	COG2244	polysaccharide biosynthetic process
D9C16_RS21780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9C16_RS21780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9C16_RS21785	COG0490	domain, Protein
D9C16_RS21790	COG5416	Lipopolysaccharide assembly protein A domain
D9C16_RS21795	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D9C16_RS21795	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D9C16_RS21800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C16_RS21805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9C16_RS21810	COG1490	D-aminoacyl-tRNA deacylase activity
D9C16_RS21815	COG4991	sh3 domain protein
D9C16_RS21815	COG3103	Sh3 type 3 domain protein
D9C16_RS21815	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C16_RS21825	COG0124	histidyl-tRNA synthetase
D9C16_RS21830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9C16_RS21840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9C16_RS21845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9C16_RS21850	COG1959	2 iron, 2 sulfur cluster binding
D9C16_RS21855	COG1104	cysteine desulfurase activity
D9C16_RS21860	COG0482	sulfurtransferase activity
D9C16_RS21865	COG0457	Tetratricopeptide repeat
D9C16_RS21870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9C16_RS21875	COG3881	PFAM PRC-barrel domain
D9C16_RS21890	COG0765	amino acid transport
D9C16_RS21895	COG0765	amino acid transport
D9C16_RS21900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C16_RS21905	COG1126	abc transporter atp-binding protein
D9C16_RS21910	COG0628	permease
D9C16_RS21915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9C16_RS21920	COG4472	Bacterial protein of unknown function (DUF965)
D9C16_RS21925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9C16_RS21930	COG3906	Belongs to the UPF0473 family
D9C16_RS21935	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9C16_RS21940	COG4122	O-methyltransferase activity
D9C16_RS21945	COG0826	peptidase U32
D9C16_RS21950	COG0826	peptidase U32
D9C16_RS21955	COG0572	uridine kinase
D9C16_RS21960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9C16_RS21965	COG0768	penicillin binding
D9C16_RS21980	COG2226	methyltransferase
D9C16_RS21985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9C16_RS21990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C16_RS21995	COG0626	cystathionine gamma-synthase activity
D9C16_RS22010	COG2427	Protein of unknown function (DUF1641)
D9C16_RS22015	COG3383	formate dehydrogenase (NAD+) activity
D9C16_RS22020	COG5609	conserved protein (DUF2294)
D9C16_RS22025	COG2116	formate transmembrane transporter activity
D9C16_RS22040	COG2226	methyltransferase
D9C16_RS22045	COG1309	transcriptional regulator
D9C16_RS22105	COG0457	Tetratricopeptide repeat
D9C16_RS22240	COG0791	NLP P60 protein
D9C16_RS22240	COG3883	PFAM NLP P60 protein
D9C16_RS22295	COG0629	single-stranded DNA binding
D9C16_RS22310	COG0582	viral genome integration into host DNA
D9C16_RS22340	COG1793	dna ligase
D9C16_RS22355	COG1525	nuclease
D9C16_RS22465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII