locus-tag	class	description
D9C18_RS00035	COG3832	glyoxalase III activity
D9C18_RS00050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C18_RS00095	COG0756	dUTP diphosphatase activity
D9C18_RS00110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9C18_RS00115	COG2814	Major facilitator Superfamily
D9C18_RS00120	COG1525	nuclease
D9C18_RS00125	COG3328	transposase activity
D9C18_RS00140	COG1070	Carbohydrate kinase
D9C18_RS00145	COG2115	Belongs to the xylose isomerase family
D9C18_RS00150	COG1940	carbohydrate kinase activity
D9C18_RS00155	COG3507	Belongs to the glycosyl hydrolase 43 family
D9C18_RS00170	COG2211	Major facilitator Superfamily
D9C18_RS00175	COG0135	phosphoribosylanthranilate isomerase activity
D9C18_RS00200	COG3655	Transcriptional regulator
D9C18_RS00215	COG3328	transposase activity
D9C18_RS00240	COG4282	regulation of fungal-type cell wall biogenesis
D9C18_RS00280	COG5444	nuclease activity
D9C18_RS00290	COG1388	LysM domain
D9C18_RS00290	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS00290	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS00335	COG5412	phage tail tape measure protein
D9C18_RS00335	COG3953	SLT domain
D9C18_RS00480	COG3646	Phage regulatory protein
D9C18_RS00480	COG3645	SOS response
D9C18_RS00500	COG4974	Belongs to the 'phage' integrase family
D9C18_RS00505	COG0174	glutamine synthetase
D9C18_RS00510	COG0789	Transcriptional regulator
D9C18_RS00515	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D9C18_RS00520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9C18_RS00525	COG0464	growth
D9C18_RS00535	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS00540	COG4112	unkown
D9C18_RS00545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9C18_RS00550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9C18_RS00555	COG1780	Probably involved in ribonucleotide reductase function
D9C18_RS00570	COG1923	regulation of RNA biosynthetic process
D9C18_RS00575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9C18_RS00590	COG2076	Multidrug Resistance protein
D9C18_RS00595	COG2076	Multidrug Resistance protein
D9C18_RS00600	COG1764	response to oxidative stress
D9C18_RS00605	COG4195	phage-related replication protein
D9C18_RS00615	COG1404	Belongs to the peptidase S8 family
D9C18_RS00620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS00630	COG3226	Transcriptional regulator
D9C18_RS00650	COG3328	transposase activity
D9C18_RS00720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9C18_RS00725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9C18_RS00735	COG4550	Control of competence regulator ComK, YlbF/YmcA
D9C18_RS00740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9C18_RS00745	COG0156	8-amino-7-oxononanoate synthase activity
D9C18_RS00750	COG1063	alcohol dehydrogenase
D9C18_RS00755	COG2359	stage V sporulation protein S
D9C18_RS00760	COG1692	metallophosphoesterase
D9C18_RS00765	COG1418	mRNA catabolic process
D9C18_RS00770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9C18_RS00775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D9C18_RS00780	COG1058	Belongs to the CinA family
D9C18_RS00780	COG1546	Belongs to the CinA family
D9C18_RS00785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9C18_RS00790	COG1426	Protein conserved in bacteria
D9C18_RS00805	COG0300	oxidoreductase activity
D9C18_RS00810	COG0612	Peptidase, M16
D9C18_RS00815	COG0612	Peptidase, M16
D9C18_RS00820	COG2814	Major facilitator Superfamily
D9C18_RS00825	COG2188	Transcriptional regulator
D9C18_RS00830	COG4980	gas vesicle protein
D9C18_RS00830	COG1674	ftsk spoiiie
D9C18_RS00840	COG0740	serine-type endopeptidase activity
D9C18_RS00845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9C18_RS00850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9C18_RS00855	COG0527	aspartate kinase activity
D9C18_RS00860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9C18_RS00865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9C18_RS00870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9C18_RS00875	COG1873	PFAM PRC-barrel domain
D9C18_RS00880	COG0612	Peptidase, M16
D9C18_RS00885	COG0726	polysaccharide deacetylase
D9C18_RS00890	COG1185	polyribonucleotide nucleotidyltransferase activity
D9C18_RS00895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9C18_RS00900	COG0196	riboflavin kinase activity
D9C18_RS00905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9C18_RS00910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9C18_RS00915	COG1550	Protein conserved in bacteria
D9C18_RS00920	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9C18_RS00925	COG1358	cellular component organization or biogenesis
D9C18_RS00930	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D9C18_RS00935	COG0195	Participates in both transcription termination and antitermination
D9C18_RS00940	COG0779	Required for maturation of 30S ribosomal subunits
D9C18_RS00945	COG2176	DNA-directed DNA polymerase activity
D9C18_RS00950	COG0442	prolyl-tRNA aminoacylation
D9C18_RS00955	COG0750	zinc metalloprotease
D9C18_RS00960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9C18_RS00965	COG4589	Belongs to the CDS family
D9C18_RS00970	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9C18_RS00975	COG0233	cytoplasmic translational termination
D9C18_RS00980	COG0528	UMP kinase activity
D9C18_RS00985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9C18_RS00990	COG0052	Belongs to the universal ribosomal protein uS2 family
D9C18_RS01000	COG1191	sigma factor activity
D9C18_RS01005	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9C18_RS01015	COG0835	chemotaxis
D9C18_RS01020	COG2198	Histidine kinase
D9C18_RS01020	COG0643	Histidine kinase
D9C18_RS01025	COG2201	protein-glutamate methylesterase activity
D9C18_RS01030	COG0455	bacterial-type flagellum organization
D9C18_RS01035	COG1419	protein localization to endoplasmic reticulum
D9C18_RS01040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9C18_RS01045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9C18_RS01050	COG1684	flagellar biosynthetic protein fliR
D9C18_RS01055	COG1987	bacterial-type flagellum assembly
D9C18_RS01060	COG1338	Plays a role in the flagellum-specific transport system
D9C18_RS01065	COG3190	flagellar
D9C18_RS01070	COG2201	protein-glutamate methylesterase activity
D9C18_RS01075	COG1776	CheC inhibitor of MCP methylation
D9C18_RS01075	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C18_RS01080	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C18_RS01085	COG1580	Controls the rotational direction of flagella during chemotaxis
D9C18_RS01090	COG1582	Flagellar protein (FlbD)
D9C18_RS01095	COG4786	Flagellar basal body rod
D9C18_RS01100	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9C18_RS01105	COG3144	bacterial-type flagellum assembly
D9C18_RS01110	COG3334	PFAM MgtE intracellular
D9C18_RS01115	COG2882	bacterial-type flagellum organization
D9C18_RS01120	COG1157	protein secretion by the type III secretion system
D9C18_RS01125	COG1317	bacterial-type flagellum organization
D9C18_RS01130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9C18_RS01140	COG1677	Flagellar hook-basal body complex protein FliE
D9C18_RS01145	COG1558	bacterial-type flagellum-dependent cell motility
D9C18_RS01150	COG1815	bacterial-type flagellum-dependent cell motility
D9C18_RS01155	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9C18_RS01160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9C18_RS01165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9C18_RS01170	COG4974	Belongs to the 'phage' integrase family
D9C18_RS01175	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D9C18_RS01180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9C18_RS01185	COG0758	DNA mediated transformation
D9C18_RS01190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9C18_RS01195	COG0045	succinate-CoA ligase (ADP-forming) activity
D9C18_RS01200	COG2257	FlhB HrpN YscU SpaS Family
D9C18_RS01215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9C18_RS01220	COG0335	large ribosomal subunit rRNA binding
D9C18_RS01225	COG0336	Belongs to the RNA methyltransferase TrmD family
D9C18_RS01230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9C18_RS01240	COG1837	Belongs to the UPF0109 family
D9C18_RS01245	COG0228	four-way junction DNA binding
D9C18_RS01250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9C18_RS01255	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D9C18_RS01265	COG0552	protein localization to endoplasmic reticulum
D9C18_RS01270	COG1196	nuclear chromosome segregation
D9C18_RS01275	COG0571	ribonuclease III activity
D9C18_RS01285	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS01290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9C18_RS01295	COG0416	fatty acid biosynthetic process
D9C18_RS01300	COG1349	DNA-binding transcription factor activity
D9C18_RS01300	COG2050	protein possibly involved in aromatic compounds catabolism
D9C18_RS01305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9C18_RS01310	COG1760	l-serine dehydratase
D9C18_RS01315	COG1760	l-serine dehydratase
D9C18_RS01320	COG1461	Dihydroxyacetone kinase
D9C18_RS01325	COG1302	Protein conserved in bacteria
D9C18_RS01330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9C18_RS01340	COG1564	THIamine pyrophosphokinase
D9C18_RS01345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9C18_RS01350	COG1162	GTPase activity
D9C18_RS01355	COG2815	serine threonine protein kinase
D9C18_RS01355	COG0515	serine threonine protein kinase
D9C18_RS01360	COG0631	protein serine/threonine phosphatase activity
D9C18_RS01365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9C18_RS01370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9C18_RS01370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9C18_RS01375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9C18_RS01380	COG0242	peptide deformylase activity
D9C18_RS01385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9C18_RS01390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9C18_RS01395	COG1758	RNA polymerase activity
D9C18_RS01400	COG0194	GDP metabolic process
D9C18_RS01410	COG1561	YicC-like family, N-terminal region
D9C18_RS01415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9C18_RS01425	COG1648	precorrin-2 dehydrogenase activity
D9C18_RS01430	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D9C18_RS01435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9C18_RS01440	COG0529	Catalyzes the synthesis of activated sulfate
D9C18_RS01445	COG2046	Belongs to the sulfate adenylyltransferase family
D9C18_RS01450	COG0306	phosphate transporter
D9C18_RS01455	COG0175	sulfate reduction
D9C18_RS01460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9C18_RS01465	COG0284	orotidine-5'-phosphate decarboxylase activity
D9C18_RS01470	COG0167	dihydroorotate dehydrogenase activity
D9C18_RS01475	COG0543	2 iron, 2 sulfur cluster binding
D9C18_RS01480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9C18_RS01485	COG0505	Belongs to the CarA family
D9C18_RS01490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9C18_RS01495	COG0540	Belongs to the ATCase OTCase family
D9C18_RS01500	COG2233	PERMEase
D9C18_RS01505	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D9C18_RS01510	COG0564	pseudouridine synthase activity
D9C18_RS01515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9C18_RS01520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C18_RS01525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9C18_RS01530	COG3599	regulation of cell shape
D9C18_RS01535	COG2302	S4 RNA-binding domain
D9C18_RS01540	COG0762	integral membrane protein
D9C18_RS01545	COG1799	cell septum assembly
D9C18_RS01550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D9C18_RS01555	COG1496	oxidoreductase activity
D9C18_RS01560	COG1873	PFAM PRC-barrel domain
D9C18_RS01565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C18_RS01570	COG1119	ATPase activity
D9C18_RS01575	COG1191	sigma factor activity
D9C18_RS01580	COG1191	sigma factor activity
D9C18_RS01590	COG4412	M6 family metalloprotease domain protein
D9C18_RS01590	COG1404	Belongs to the peptidase S8 family
D9C18_RS01595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9C18_RS01600	COG0849	cell division
D9C18_RS01605	COG3856	small basic protein
D9C18_RS01610	COG3879	Bacterial protein of unknown function (DUF881)
D9C18_RS01615	COG3879	Bacterial protein of unknown function (DUF881)
D9C18_RS01620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9C18_RS01625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9C18_RS01630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C18_RS01635	COG0772	Belongs to the SEDS family
D9C18_RS01640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9C18_RS01645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9C18_RS01650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9C18_RS01655	COG0768	penicillin binding
D9C18_RS01660	COG0768	penicillin binding
D9C18_RS01665	COG4839	cell division protein FtsL
D9C18_RS01670	COG0275	rRNA processing
D9C18_RS01675	COG2001	Belongs to the MraZ family
D9C18_RS01680	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D9C18_RS01685	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9C18_RS01690	COG0454	-acetyltransferase
D9C18_RS01705	COG1399	metal-binding, possibly nucleic acid-binding protein
D9C18_RS01715	COG1323	Belongs to the UPF0348 family
D9C18_RS01720	COG3480	Lon protease (S16) C-terminal proteolytic domain
D9C18_RS01725	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9C18_RS01730	COG3314	Sporulation integral membrane protein YlbJ
D9C18_RS01735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9C18_RS01740	COG0742	ribosomal rna small subunit methyltransferase
D9C18_RS01745	COG4471	UPF0298 protein
D9C18_RS01750	COG3679	Belongs to the UPF0342 family
D9C18_RS01765	COG2340	Cysteine-rich secretory protein family
D9C18_RS01770	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D9C18_RS01780	COG3336	cytochrome c oxidase
D9C18_RS01785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9C18_RS01790	COG1845	cytochrome c oxidase, subunit III
D9C18_RS01795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9C18_RS01800	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9C18_RS01800	COG2010	Cytochrome c
D9C18_RS01805	COG0109	protoheme IX farnesyltransferase activity
D9C18_RS01810	COG1612	heme a metabolic process
D9C18_RS01815	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D9C18_RS01820	COG0772	Belongs to the SEDS family
D9C18_RS01825	COG4838	Belongs to the UPF0358 family
D9C18_RS01835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9C18_RS01840	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9C18_RS01850	COG4896	Protein conserved in bacteria
D9C18_RS01860	COG1217	gtp-binding protein TYPA
D9C18_RS01905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D9C18_RS01920	COG0483	inositol monophosphate 1-phosphatase activity
D9C18_RS01930	COG4493	Belongs to the UPF0637 family
D9C18_RS01935	COG4476	Belongs to the UPF0223 family
D9C18_RS01940	COG1982	Orn Lys Arg decarboxylase major
D9C18_RS01950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS01955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C18_RS01960	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C18_RS01965	COG0022	dehydrogenase e1 component
D9C18_RS01970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C18_RS01985	COG0242	peptide deformylase activity
D9C18_RS01990	COG0561	phosphatase activity
D9C18_RS01995	COG5503	Protein of unknown function (DUF1447)
D9C18_RS02000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D9C18_RS02005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9C18_RS02010	COG0569	domain protein
D9C18_RS02015	COG2105	PFAM AIG2 family protein
D9C18_RS02015	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D9C18_RS02020	COG3852	Histidine kinase
D9C18_RS02025	COG2002	toxin-antitoxin pair type II binding
D9C18_RS02030	COG1077	Cell shape determining protein MreB Mrl
D9C18_RS02040	COG2309	aminopeptidase activity
D9C18_RS02045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9C18_RS02050	COG0488	(ABC) transporter
D9C18_RS02060	COG0681	Belongs to the peptidase S26 family
D9C18_RS02065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C18_RS02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS02065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C18_RS02070	COG1105	Belongs to the carbohydrate kinase PfkB family
D9C18_RS02075	COG1349	DNA-binding transcription factor activity
D9C18_RS02080	COG0577	efflux transmembrane transporter activity
D9C18_RS02085	COG1136	(ABC) transporter
D9C18_RS02090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9C18_RS02100	COG1132	(ABC) transporter
D9C18_RS02110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9C18_RS02115	COG0314	molybdopterin synthase activity
D9C18_RS02120	COG1763	Mo-molybdopterin cofactor biosynthetic process
D9C18_RS02125	COG0303	'Molybdopterin
D9C18_RS02130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C18_RS02135	COG0746	molybdenum cofactor guanylyltransferase activity
D9C18_RS02155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS02160	COG0450	alkyl hydroperoxide reductase
D9C18_RS02165	COG0668	transmembrane transport
D9C18_RS02175	COG1473	amidohydrolase
D9C18_RS02180	COG2171	N-acyltransferase activity
D9C18_RS02185	COG0716	FMN binding
D9C18_RS02195	COG0716	FMN binding
D9C18_RS02200	COG0583	DNA-binding transcription factor activity
D9C18_RS02205	COG0517	IMP dehydrogenase activity
D9C18_RS02215	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D9C18_RS02220	COG4703	Protein of unknown function (DUF1797)
D9C18_RS02225	COG2200	EAL domain
D9C18_RS02230	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS02235	COG1408	metallophosphoesterase
D9C18_RS02240	COG1376	ErfK ybiS ycfS ynhG family protein
D9C18_RS02245	COG2814	Major facilitator Superfamily
D9C18_RS02255	COG0835	chemotaxis
D9C18_RS02255	COG0784	Response regulator, receiver
D9C18_RS02265	COG0436	Aminotransferase
D9C18_RS02270	COG4191	Histidine kinase
D9C18_RS02275	COG0768	penicillin binding
D9C18_RS02280	COG2340	Cysteine-rich secretory protein family
D9C18_RS02290	COG3328	transposase activity
D9C18_RS02295	COG2084	Dehydrogenase
D9C18_RS02300	COG0840	transmembrane signaling receptor activity
D9C18_RS02305	COG0456	acetyltransferase
D9C18_RS02310	COG1533	DNA photolyase activity
D9C18_RS02320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9C18_RS02325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS02330	COG2190	(PTS) system
D9C18_RS02330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS02330	COG1263	PTS System
D9C18_RS02335	COG3711	transcriptional antiterminator
D9C18_RS02340	COG1609	Transcriptional regulator
D9C18_RS02345	COG0006	proline dipeptidase activity
D9C18_RS02355	COG2217	Heavy metal translocating P-type atpase
D9C18_RS02360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS02365	COG2244	polysaccharide biosynthetic process
D9C18_RS02370	COG3773	Cell wall hydrolase
D9C18_RS02380	COG4873	Protein conserved in bacteria
D9C18_RS02390	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9C18_RS02395	COG0602	queuosine metabolic process
D9C18_RS02400	COG0720	synthase
D9C18_RS02405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9C18_RS02410	COG3949	Membrane
D9C18_RS02415	COG0542	response to heat
D9C18_RS02420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9C18_RS02425	COG1360	Flagellar Motor Protein
D9C18_RS02430	COG1846	Transcriptional regulator
D9C18_RS02435	COG3852	Histidine kinase
D9C18_RS02450	COG3339	Conserved Protein
D9C18_RS02455	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9C18_RS02460	COG0235	Class ii aldolase
D9C18_RS02465	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D9C18_RS02470	COG1850	ribulose-bisphosphate carboxylase activity
D9C18_RS02475	COG0436	Aminotransferase
D9C18_RS02480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9C18_RS02485	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D9C18_RS02490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9C18_RS02500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9C18_RS02505	COG5002	protein histidine kinase activity
D9C18_RS02510	COG3594	Acyltransferase
D9C18_RS02530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9C18_RS02535	COG0501	Belongs to the peptidase M48B family
D9C18_RS02555	COG1191	sigma factor activity
D9C18_RS02560	COG0861	Integral membrane protein TerC family
D9C18_RS02565	COG0586	Pfam SNARE associated Golgi protein
D9C18_RS02570	COG5001	Diguanylate cyclase
D9C18_RS02570	COG3300	MHYT domain
D9C18_RS02575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D9C18_RS02580	COG1793	dna ligase
D9C18_RS02580	COG3285	dna ligase
D9C18_RS02585	COG0463	Glycosyl transferase, family 2
D9C18_RS02595	COG1408	metallophosphoesterase
D9C18_RS02600	COG0726	polysaccharide deacetylase
D9C18_RS02605	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C18_RS02610	COG1846	Transcriptional regulator
D9C18_RS02625	COG0789	Transcriptional regulator
D9C18_RS02630	COG2239	Acts as a magnesium transporter
D9C18_RS02645	COG3212	peptidase
D9C18_RS02650	COG3212	peptidase
D9C18_RS02655	COG3850	Histidine kinase
D9C18_RS02655	COG5002	protein histidine kinase activity
D9C18_RS02660	COG0745	RESPONSE REGULATOR receiver
D9C18_RS02670	COG4721	ABC-type cobalt transport system, permease component
D9C18_RS02675	COG1122	ATPase activity
D9C18_RS02680	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D9C18_RS02685	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS02690	COG1404	Belongs to the peptidase S8 family
D9C18_RS02695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C18_RS02705	COG0590	tRNA wobble adenosine to inosine editing
D9C18_RS02715	COG1764	response to oxidative stress
D9C18_RS02720	COG1846	Transcriptional regulator
D9C18_RS02725	COG1764	response to oxidative stress
D9C18_RS02730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9C18_RS02735	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9C18_RS02740	COG0788	formyltetrahydrofolate deformylase activity
D9C18_RS02745	COG2076	Multidrug Resistance protein
D9C18_RS02750	COG2076	Multidrug Resistance protein
D9C18_RS02755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS02760	COG2318	DinB family
D9C18_RS02765	COG2323	membrane
D9C18_RS02775	COG1017	nitric oxide dioxygenase activity
D9C18_RS02775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9C18_RS02780	COG1607	acyl-coa hydrolase
D9C18_RS02790	COG2706	6-phosphogluconolactonase activity
D9C18_RS02795	COG4608	Belongs to the ABC transporter superfamily
D9C18_RS02800	COG0791	NLP P60 protein
D9C18_RS02805	COG4948	Mandelate Racemase Muconate Lactonizing
D9C18_RS02810	COG1619	proteins homologs of microcin C7 resistance protein MccF
D9C18_RS02815	COG4166	transmembrane transport
D9C18_RS02820	COG0444	Belongs to the ABC transporter superfamily
D9C18_RS02825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C18_RS02830	COG0601	transmembrane transport
D9C18_RS02835	COG2362	D-Aminopeptidase
D9C18_RS02840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C18_RS02845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C18_RS02850	COG0463	Glycosyl transferase, family 2
D9C18_RS02855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D9C18_RS02860	COG0346	lactoylglutathione lyase activity
D9C18_RS02865	COG0531	amino acid
D9C18_RS02870	COG1392	Phosphate transport regulator
D9C18_RS02875	COG0306	phosphate transporter
D9C18_RS02895	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS02895	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS02935	COG3778	Protein conserved in bacteria
D9C18_RS02940	COG3299	homolog of phage Mu protein gp47
D9C18_RS02945	COG3628	GPW Gp25 family protein
D9C18_RS02955	COG4193	domain, Protein
D9C18_RS02960	COG1652	LysM domain
D9C18_RS02965	COG3953	SLT domain
D9C18_RS02965	COG5412	phage tail tape measure protein
D9C18_RS02965	COG5412	phage tail tape measure protein
D9C18_RS02965	COG3953	SLT domain
D9C18_RS02965	COG3953	SLT domain
D9C18_RS02965	COG5412	phage tail tape measure protein
D9C18_RS03015	COG4653	Phage capsid family
D9C18_RS03020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D9C18_RS03025	COG5518	Phage portal protein
D9C18_RS03030	COG1783	phage Terminase large subunit
D9C18_RS03035	COG5484	DNA packaging
D9C18_RS03035	COG3728	DNA packaging
D9C18_RS03040	COG1595	DNA-templated transcription, initiation
D9C18_RS03060	COG1484	DNA-dependent DNA replication
D9C18_RS03065	COG1522	sequence-specific DNA binding
D9C18_RS03075	COG1396	sequence-specific DNA binding
D9C18_RS03080	COG2856	Zn peptidase
D9C18_RS03090	COG4195	phage-related replication protein
D9C18_RS03100	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS03100	COG1388	LysM domain
D9C18_RS03100	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS03115	COG0457	Tetratricopeptide repeat
D9C18_RS03135	COG2318	DinB family
D9C18_RS03140	COG0730	response to heat
D9C18_RS03145	COG2721	sulfolactate sulfo-lyase activity
D9C18_RS03150	COG0246	Mannitol dehydrogenase
D9C18_RS03155	COG1609	Transcriptional regulator
D9C18_RS03160	COG2271	Major facilitator Superfamily
D9C18_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS03170	COG1312	Catalyzes the dehydration of D-mannonate
D9C18_RS03175	COG1063	alcohol dehydrogenase
D9C18_RS03180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9C18_RS03185	COG2211	Major facilitator Superfamily
D9C18_RS03190	COG1904	glucuronate isomerase
D9C18_RS03195	COG1252	NADH dehydrogenase
D9C18_RS03210	COG0697	spore germination
D9C18_RS03215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C18_RS03220	COG0390	transport system, permease component
D9C18_RS03225	COG1587	Uroporphyrinogen-III synthase
D9C18_RS03235	COG1819	glycosyl
D9C18_RS03240	COG2124	cytochrome p450
D9C18_RS03250	COG1051	belongs to the nudix hydrolase family
D9C18_RS03260	COG2427	Protein of unknown function (DUF1641)
D9C18_RS03275	COG2205	protein histidine kinase activity
D9C18_RS03280	COG5504	Zn-dependent protease
D9C18_RS03295	COG0726	polysaccharide deacetylase
D9C18_RS03305	COG0109	protoheme IX farnesyltransferase activity
D9C18_RS03325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9C18_RS03335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS03340	COG3328	transposase activity
D9C18_RS03355	COG1482	cell wall glycoprotein biosynthetic process
D9C18_RS03360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C18_RS03360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9C18_RS03360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS03365	COG3711	transcriptional antiterminator
D9C18_RS03365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS03375	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D9C18_RS03435	COG3328	transposase activity
D9C18_RS03450	COG5444	nuclease activity
D9C18_RS03455	COG0457	Tetratricopeptide repeat
D9C18_RS03520	COG1396	sequence-specific DNA binding
D9C18_RS03555	COG5505	Protein of unknown function (DUF819)
D9C18_RS03560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS03565	COG0626	cystathionine gamma-synthase activity
D9C18_RS03570	COG0626	cystathionine gamma-synthase activity
D9C18_RS03575	COG2382	esterase
D9C18_RS03580	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9C18_RS03585	COG2153	protein acetylation
D9C18_RS03595	COG0210	DNA helicase
D9C18_RS03650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9C18_RS03655	COG0351	phosphomethylpyrimidine kinase
D9C18_RS03660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C18_RS03665	COG2022	thiamine diphosphate biosynthetic process
D9C18_RS03670	COG2104	thiamine diphosphate biosynthetic process
D9C18_RS03675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9C18_RS03680	COG0352	thiamine-phosphate diphosphorylase activity
D9C18_RS03685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D9C18_RS03690	COG0475	glutathione-regulated potassium exporter activity
D9C18_RS03690	COG0569	domain protein
D9C18_RS03695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9C18_RS03700	COG0564	pseudouridine synthase activity
D9C18_RS03705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9C18_RS03710	COG2357	RelA SpoT domain protein
D9C18_RS03720	COG4116	CYTH
D9C18_RS03725	COG0741	lytic transglycosylase activity
D9C18_RS03730	COG2346	COG2346, Truncated hemoglobins
D9C18_RS03735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9C18_RS03750	COG1164	Oligoendopeptidase f
D9C18_RS03755	COG4469	Competence protein
D9C18_RS03765	COG4862	establishment of competence for transformation
D9C18_RS03775	COG0861	Integral membrane protein TerC family
D9C18_RS03780	COG1393	Belongs to the ArsC family
D9C18_RS03785	COG0456	acetyltransferase
D9C18_RS03790	COG2814	Major facilitator Superfamily
D9C18_RS03795	COG4608	Belongs to the ABC transporter superfamily
D9C18_RS03800	COG0444	Belongs to the ABC transporter superfamily
D9C18_RS03805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C18_RS03810	COG0601	transmembrane transport
D9C18_RS03815	COG4166	transmembrane transport
D9C18_RS03820	COG0180	Tryptophanyl-tRNA synthetase
D9C18_RS03830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9C18_RS03835	COG0601	transmembrane transport
D9C18_RS03845	COG4608	Belongs to the ABC transporter superfamily
D9C18_RS03850	COG0444	Belongs to the ABC transporter superfamily
D9C18_RS03855	COG5504	Zn-dependent protease
D9C18_RS03860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9C18_RS03865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9C18_RS03880	COG1744	ABC transporter substrate-binding protein PnrA-like
D9C18_RS03890	COG2267	carboxylic ester hydrolase activity
D9C18_RS03910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9C18_RS03915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9C18_RS03920	COG0505	Belongs to the CarA family
D9C18_RS03925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9C18_RS03935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9C18_RS03940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9C18_RS03960	COG2151	metal-sulfur cluster biosynthetic enzyme
D9C18_RS03965	COG1073	alpha beta
D9C18_RS03970	COG0561	phosphatase activity
D9C18_RS03985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS03990	COG1307	EDD domain protein, DegV family
D9C18_RS04000	COG2996	Protein conserved in bacteria
D9C18_RS04005	COG1666	GTP binding
D9C18_RS04010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9C18_RS04010	COG0646	methionine synthase
D9C18_RS04015	COG2153	protein acetylation
D9C18_RS04025	COG2267	carboxylic ester hydrolase activity
D9C18_RS04030	COG1357	PFAM Pentapeptide repeats (8 copies)
D9C18_RS04035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS04040	COG1279	arginine transmembrane transporter activity
D9C18_RS04045	COG2318	DinB family
D9C18_RS04050	COG0673	inositol 2-dehydrogenase activity
D9C18_RS04055	COG1609	Transcriptional regulator
D9C18_RS04060	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS04060	COG2207	Transcriptional regulator
D9C18_RS04065	COG0534	Mate efflux family protein
D9C18_RS04070	COG1562	ergosterol biosynthetic process
D9C18_RS04075	COG0367	asparagine synthase
D9C18_RS04085	COG1404	Belongs to the peptidase S8 family
D9C18_RS04095	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9C18_RS04100	COG5337	Spore coat protein CotH
D9C18_RS04140	COG1403	HNH endonuclease
D9C18_RS04145	COG0419	ATPase involved in DNA repair
D9C18_RS04150	COG0420	3'-5' exonuclease activity
D9C18_RS04155	COG1074	ATP-dependent DNA helicase activity
D9C18_RS04160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D9C18_RS04165	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D9C18_RS04185	COG4533	DNA binding
D9C18_RS04190	COG2814	Major facilitator Superfamily
D9C18_RS04190	COG0477	Major facilitator Superfamily
D9C18_RS04195	COG3180	Ammonia monooxygenase
D9C18_RS04200	COG1609	Transcriptional regulator
D9C18_RS04205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C18_RS04210	COG0561	phosphatase activity
D9C18_RS04215	COG0673	inositol 2-dehydrogenase activity
D9C18_RS04220	COG0738	Major facilitator superfamily
D9C18_RS04235	COG1846	Transcriptional regulator
D9C18_RS04240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9C18_RS04245	COG0681	Belongs to the peptidase S26 family
D9C18_RS04250	COG0398	Pfam SNARE associated Golgi protein
D9C18_RS04265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C18_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS04280	COG4903	ComK protein
D9C18_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS04300	COG0840	transmembrane signaling receptor activity
D9C18_RS04305	COG1268	BioY protein
D9C18_RS04310	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS04315	COG0183	Belongs to the thiolase family
D9C18_RS04320	COG0406	alpha-ribazole phosphatase activity
D9C18_RS04325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D9C18_RS04330	COG0604	alcohol dehydrogenase
D9C18_RS04335	COG0456	acetyltransferase
D9C18_RS04345	COG0501	Belongs to the peptidase M48B family
D9C18_RS04355	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS04360	COG0702	epimerase
D9C18_RS04365	COG0095	Lipoate-protein ligase
D9C18_RS04370	COG1234	tRNA 3'-trailer cleavage
D9C18_RS04380	COG1301	dicarboxylic acid transport
D9C18_RS04385	COG4405	Protein conserved in bacteria
D9C18_RS04390	COG1363	Peptidase, m42
D9C18_RS04400	COG4377	Putative membrane peptidase family (DUF2324)
D9C18_RS04405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9C18_RS04410	COG1511	domain protein
D9C18_RS04415	COG1309	transcriptional regulator
D9C18_RS04420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D9C18_RS04425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9C18_RS04430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9C18_RS04435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C18_RS04440	COG2329	Antibiotic biosynthesis monooxygenase
D9C18_RS04450	COG3069	C4-dicarboxylate transmembrane transporter activity
D9C18_RS04455	COG1473	amidohydrolase
D9C18_RS04465	COG4473	ABC transporter
D9C18_RS04470	COG1131	(ABC) transporter
D9C18_RS04475	COG0537	adenosine 5'-monophosphoramidase activity
D9C18_RS04480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9C18_RS04495	COG4980	gas vesicle protein
D9C18_RS04500	COG1846	Transcriptional regulator
D9C18_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9C18_RS04540	COG3481	metal-dependent phosphohydrolase, HD sub domain
D9C18_RS04545	COG4717	serine-type aminopeptidase activity
D9C18_RS04550	COG0420	3'-5' exonuclease activity
D9C18_RS04555	COG1668	transmembrane transport
D9C18_RS04560	COG4152	abc transporter atp-binding protein
D9C18_RS04570	COG1024	Enoyl-CoA hydratase
D9C18_RS04580	COG0490	domain, Protein
D9C18_RS04585	COG0475	glutathione-regulated potassium exporter activity
D9C18_RS04590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9C18_RS04595	COG0561	phosphatase activity
D9C18_RS04605	COG3679	Belongs to the UPF0342 family
D9C18_RS04610	COG4399	Belongs to the UPF0754 family
D9C18_RS04615	COG0189	ligase activity
D9C18_RS04620	COG0189	ligase activity
D9C18_RS04645	COG0702	epimerase
D9C18_RS04650	COG1132	(ABC) transporter
D9C18_RS04655	COG1132	(ABC) transporter
D9C18_RS04665	COG0589	response to stress
D9C18_RS04670	COG1757	Na H antiporter
D9C18_RS04675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C18_RS04680	COG0726	polysaccharide deacetylase
D9C18_RS04685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9C18_RS04690	COG0668	transmembrane transport
D9C18_RS04700	COG0584	glycerophosphoryl diester phosphodiesterase
D9C18_RS04705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9C18_RS04710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9C18_RS04715	COG1253	flavin adenine dinucleotide binding
D9C18_RS04725	COG0789	Transcriptional regulator
D9C18_RS04730	COG1253	flavin adenine dinucleotide binding
D9C18_RS04735	COG0204	Acyl-transferase
D9C18_RS04740	COG0667	Aldo Keto reductase
D9C18_RS04745	COG1595	DNA-templated transcription, initiation
D9C18_RS04760	COG0456	acetyltransferase
D9C18_RS04765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS04770	COG0733	neurotransmitter:sodium symporter activity
D9C18_RS04775	COG0531	amino acid
D9C18_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS04785	COG0372	Belongs to the citrate synthase family
D9C18_RS04790	COG0583	DNA-binding transcription factor activity
D9C18_RS04795	COG0791	NLP P60 protein
D9C18_RS04795	COG1388	LysM domain
D9C18_RS04800	COG1785	Belongs to the alkaline phosphatase family
D9C18_RS04805	COG2719	SpoVR family
D9C18_RS04810	COG0668	transmembrane transport
D9C18_RS04815	COG1959	2 iron, 2 sulfur cluster binding
D9C18_RS04820	COG0791	NLP P60 protein
D9C18_RS04820	COG1388	LysM domain
D9C18_RS04835	COG0431	NADPH-dependent FMN reductase
D9C18_RS04840	COG2197	response regulator
D9C18_RS04845	COG4585	Histidine kinase
D9C18_RS04845	COG2203	Gaf domain
D9C18_RS04850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9C18_RS04855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9C18_RS04860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9C18_RS04865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D9C18_RS04870	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D9C18_RS04875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C18_RS04880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9C18_RS04880	COG3153	acetyltransferase
D9C18_RS04885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9C18_RS04890	COG0517	IMP dehydrogenase activity
D9C18_RS04900	COG0564	pseudouridine synthase activity
D9C18_RS04905	COG3764	Sortase (surface protein transpeptidase)
D9C18_RS04910	COG4085	toxin activity
D9C18_RS04910	COG1525	nuclease
D9C18_RS04910	COG0737	Belongs to the 5'-nucleotidase family
D9C18_RS04935	COG0457	Tetratricopeptide repeat
D9C18_RS04955	COG0791	NLP P60 protein
D9C18_RS04955	COG0741	lytic transglycosylase activity
D9C18_RS04960	COG5644	endopeptidase inhibitor activity
D9C18_RS05010	COG2946	Replication initiation factor
D9C18_RS05015	COG0582	viral genome integration into host DNA
D9C18_RS05040	COG5444	nuclease activity
D9C18_RS05045	COG1823	symporter activity
D9C18_RS05050	COG3706	GGDEF domain
D9C18_RS05055	COG1464	Belongs to the NlpA lipoprotein family
D9C18_RS05065	COG1278	Cold shock
D9C18_RS05070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C18_RS05075	COG1131	(ABC) transporter
D9C18_RS05080	COG1131	(ABC) transporter
D9C18_RS05085	COG1725	Transcriptional regulator
D9C18_RS05105	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9C18_RS05110	COG2814	Major facilitator Superfamily
D9C18_RS05115	COG1566	PFAM secretion protein HlyD family protein
D9C18_RS05120	COG1846	Transcriptional regulator
D9C18_RS05125	COG2718	Belongs to the UPF0229 family
D9C18_RS05130	COG2766	serine protein kinase
D9C18_RS05135	COG1664	Polymer-forming cytoskeletal
D9C18_RS05140	COG1664	Polymer-forming cytoskeletal
D9C18_RS05145	COG0789	Transcriptional regulator
D9C18_RS05150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9C18_RS05160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D9C18_RS05165	COG3382	B3 4 domain protein
D9C18_RS05175	COG1476	TRANSCRIPTIONal
D9C18_RS05185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9C18_RS05195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C18_RS05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9C18_RS05205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9C18_RS05210	COG1116	anion transmembrane transporter activity
D9C18_RS05215	COG0753	catalase activity
D9C18_RS05230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9C18_RS05235	COG3340	Belongs to the peptidase S51 family
D9C18_RS05240	COG5577	PFAM Coat F domain
D9C18_RS05250	COG4326	sporulation control protein
D9C18_RS05360	COG0735	belongs to the Fur family
D9C18_RS05365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9C18_RS05370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9C18_RS05375	COG4129	membrane
D9C18_RS05380	COG1132	(ABC) transporter
D9C18_RS05385	COG3557	Belongs to the UPF0374 family
D9C18_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS05410	COG1194	a g-specific adenine glycosylase
D9C18_RS05415	COG1988	membrane-bound metal-dependent
D9C18_RS05420	COG4485	Bacterial membrane protein, YfhO
D9C18_RS05425	COG0463	Glycosyl transferase, family 2
D9C18_RS05430	COG0596	Alpha beta hydrolase
D9C18_RS05435	COG5658	integral membrane protein
D9C18_RS05440	COG3103	Sh3 type 3 domain protein
D9C18_RS05455	COG2814	Major facilitator Superfamily
D9C18_RS05465	COG2137	regulation of response to DNA damage stimulus
D9C18_RS05470	COG1090	epimerase
D9C18_RS05485	COG0778	Nitroreductase
D9C18_RS05490	COG0384	phenazine biosynthesis protein PhzF
D9C18_RS05495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS05500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS05505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS05510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D9C18_RS05510	COG0392	lysyltransferase activity
D9C18_RS05515	COG1846	Transcriptional regulator
D9C18_RS05525	COG2318	DinB family
D9C18_RS05530	COG2814	Major facilitator Superfamily
D9C18_RS05535	COG1309	transcriptional regulator
D9C18_RS05540	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D9C18_RS05545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D9C18_RS05550	COG1695	Transcriptional regulator
D9C18_RS05555	COG0842	Transport permease protein
D9C18_RS05560	COG1511	domain protein
D9C18_RS05560	COG0842	Transport permease protein
D9C18_RS05565	COG1131	(ABC) transporter
D9C18_RS05570	COG2197	response regulator
D9C18_RS05575	COG4585	Histidine kinase
D9C18_RS05585	COG1082	Xylose isomerase domain protein TIM barrel
D9C18_RS05590	COG2814	Major facilitator Superfamily
D9C18_RS05595	COG4977	sequence-specific DNA binding
D9C18_RS05595	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS05600	COG2514	catechol 2,3-dioxygenase activity
D9C18_RS05605	COG2259	Doxx family
D9C18_RS05610	COG1132	(ABC) transporter
D9C18_RS05615	COG1132	(ABC) transporter
D9C18_RS05620	COG5434	Belongs to the glycosyl hydrolase 28 family
D9C18_RS05625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS05625	COG1263	PTS System
D9C18_RS05630	COG1737	Transcriptional regulator
D9C18_RS05635	COG1486	melibiose metabolic process
D9C18_RS05640	COG4842	Belongs to the WXG100 family
D9C18_RS05665	COG1742	UPF0060 membrane protein
D9C18_RS05675	COG3284	Transcriptional regulator
D9C18_RS05680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C18_RS05685	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C18_RS05690	COG0022	dehydrogenase e1 component
D9C18_RS05695	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C18_RS05705	COG4637	Psort location Cytoplasmic, score
D9C18_RS05720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9C18_RS05725	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D9C18_RS05730	COG0598	Magnesium transport protein CorA
D9C18_RS05735	COG2084	Dehydrogenase
D9C18_RS05740	COG0726	polysaccharide deacetylase
D9C18_RS05750	COG0535	radical SAM domain protein
D9C18_RS05755	COG0668	transmembrane transport
D9C18_RS05765	COG0387	Pfam Sodium calcium exchanger
D9C18_RS05770	COG0477	Major facilitator Superfamily
D9C18_RS05775	COG1295	ribonuclease BN
D9C18_RS05780	COG4980	gas vesicle protein
D9C18_RS05785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9C18_RS05790	COG4840	Belongs to the UPF0435 family
D9C18_RS05795	COG2814	Major facilitator Superfamily
D9C18_RS05805	COG0693	protein deglycase activity
D9C18_RS05810	COG0737	Belongs to the 5'-nucleotidase family
D9C18_RS05815	COG0778	Nitroreductase
D9C18_RS05820	COG2188	Transcriptional regulator
D9C18_RS05825	COG0366	Alpha amylase catalytic
D9C18_RS05830	COG1263	PTS System
D9C18_RS05830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS05835	COG0697	spore germination
D9C18_RS05850	COG1115	amino acid carrier protein
D9C18_RS05865	COG1368	sulfuric ester hydrolase activity
D9C18_RS05870	COG1263	PTS System
D9C18_RS05870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS05875	COG0024	Methionine aminopeptidase
D9C18_RS05895	COG2258	MOSC domain
D9C18_RS05900	COG1254	Belongs to the acylphosphatase family
D9C18_RS05905	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D9C18_RS05910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS05915	COG2851	Citrate transporter
D9C18_RS05920	COG3181	Tripartite tricarboxylate transporter family receptor
D9C18_RS05925	COG4565	transcriptional regulatory protein
D9C18_RS05930	COG3290	protein histidine kinase activity
D9C18_RS05935	COG0471	metal ion transport
D9C18_RS05940	COG3866	Pectate lyase
D9C18_RS05950	COG0513	Belongs to the DEAD box helicase family
D9C18_RS05955	COG0488	(ABC) transporter
D9C18_RS05975	COG2814	Major facilitator Superfamily
D9C18_RS05980	COG0789	Transcriptional regulator
D9C18_RS05990	COG0488	(ABC) transporter
D9C18_RS05995	COG0840	transmembrane signaling receptor activity
D9C18_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS06005	COG0531	amino acid
D9C18_RS06010	COG1011	Hydrolase
D9C18_RS06015	COG2223	nitrite transmembrane transporter activity
D9C18_RS06020	COG1442	glycosyl transferase family 8
D9C18_RS06025	COG1216	Glycosyl transferase, family 2
D9C18_RS06030	COG1442	glycosyl transferase family 8
D9C18_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C18_RS06040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9C18_RS06045	COG1368	sulfuric ester hydrolase activity
D9C18_RS06055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9C18_RS06055	COG2124	cytochrome p450
D9C18_RS06065	COG3328	transposase activity
D9C18_RS06080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9C18_RS06085	COG0670	Belongs to the BI1 family
D9C18_RS06090	COG5583	Uncharacterized small protein (DUF2292)
D9C18_RS06105	COG0346	lactoylglutathione lyase activity
D9C18_RS06110	COG2329	Antibiotic biosynthesis monooxygenase
D9C18_RS06115	COG2323	membrane
D9C18_RS06120	COG1486	melibiose metabolic process
D9C18_RS06125	COG0395	ABC-type sugar transport system, permease component
D9C18_RS06130	COG4209	transmembrane transport
D9C18_RS06135	COG1653	transport
D9C18_RS06150	COG2755	lipolytic protein G-D-S-L family
D9C18_RS06155	COG3401	FG-GAP repeat protein
D9C18_RS06160	COG3401	FG-GAP repeat protein
D9C18_RS06165	COG5578	integral membrane protein
D9C18_RS06175	COG2755	lipolytic protein G-D-S-L family
D9C18_RS06180	COG2207	Transcriptional regulator
D9C18_RS06185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9C18_RS06190	COG0395	ABC-type sugar transport system, permease component
D9C18_RS06195	COG1175	transmembrane transport
D9C18_RS06200	COG1653	transport
D9C18_RS06210	COG2972	Histidine kinase
D9C18_RS06215	COG5578	integral membrane protein
D9C18_RS06225	COG0454	-acetyltransferase
D9C18_RS06230	COG3546	catalase activity
D9C18_RS06245	COG1309	transcriptional regulator
D9C18_RS06255	COG0217	transcriptional regulatory protein
D9C18_RS06265	COG0457	Tetratricopeptide repeat
D9C18_RS06275	COG5444	nuclease activity
D9C18_RS06310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9C18_RS06315	COG1597	lipid kinase activity
D9C18_RS06320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9C18_RS06325	COG1309	transcriptional regulator
D9C18_RS06330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9C18_RS06335	COG0154	amidase activity
D9C18_RS06340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9C18_RS06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C18_RS06350	COG1285	pathogenesis
D9C18_RS06355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C18_RS06365	COG4851	CamS sex pheromone cAM373 precursor
D9C18_RS06370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9C18_RS06375	COG0210	DNA helicase
D9C18_RS06380	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D9C18_RS06385	COG0069	glutamate synthase activity
D9C18_RS06390	COG4496	protein, YerC YecD
D9C18_RS06395	COG1470	cell adhesion involved in biofilm formation
D9C18_RS06400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9C18_RS06410	COG0531	amino acid
D9C18_RS06415	COG1522	sequence-specific DNA binding
D9C18_RS06420	COG0151	Belongs to the GarS family
D9C18_RS06425	COG0138	bifunctional purine biosynthesis protein purh
D9C18_RS06430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9C18_RS06435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9C18_RS06440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9C18_RS06445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9C18_RS06450	COG0047	phosphoribosylformylglycinamidine synthase activity
D9C18_RS06455	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9C18_RS06460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9C18_RS06465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9C18_RS06470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9C18_RS06475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D9C18_RS06485	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D9C18_RS06495	COG3064	Membrane
D9C18_RS06500	COG2252	PERMEase
D9C18_RS06510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9C18_RS06510	COG0519	Catalyzes the synthesis of GMP from XMP
D9C18_RS06515	COG1305	Transglutaminase-like
D9C18_RS06520	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D9C18_RS06525	COG0714	Associated with various cellular activities
D9C18_RS06530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C18_RS06540	COG1113	amino acid transport
D9C18_RS06545	COG2132	Multicopper oxidase
D9C18_RS06555	COG2267	carboxylic ester hydrolase activity
D9C18_RS06575	COG0823	Involved in the tonB-independent uptake of proteins
D9C18_RS06580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9C18_RS06585	COG1063	alcohol dehydrogenase
D9C18_RS06590	COG2814	Major facilitator Superfamily
D9C18_RS06600	COG4260	virion core protein, lumpy skin disease virus
D9C18_RS06605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D9C18_RS06610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9C18_RS06620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C18_RS06625	COG2211	Major facilitator Superfamily
D9C18_RS06630	COG1063	alcohol dehydrogenase
D9C18_RS06635	COG0457	Tetratricopeptide repeat
D9C18_RS06650	COG0459	protein refolding
D9C18_RS06660	COG1266	CAAX protease self-immunity
D9C18_RS06675	COG0805	protein transport
D9C18_RS06680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C18_RS06685	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D9C18_RS06690	COG0315	cyclic pyranopterin monophosphate synthase activity
D9C18_RS06695	COG0488	(ABC) transporter
D9C18_RS06705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9C18_RS06710	COG0456	acetyltransferase
D9C18_RS06715	COG1214	PFAM Peptidase M22, glycoprotease
D9C18_RS06720	COG0802	atpase or kinase
D9C18_RS06725	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9C18_RS06770	COG4124	Belongs to the glycosyl hydrolase 26 family
D9C18_RS06780	COG1940	carbohydrate kinase activity
D9C18_RS06785	COG2188	Transcriptional regulator
D9C18_RS06790	COG2723	6-phospho-beta-galactosidase activity
D9C18_RS06805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C18_RS06810	COG2814	Major facilitator Superfamily
D9C18_RS06815	COG1388	LysM domain
D9C18_RS06820	COG1078	dGTPase activity
D9C18_RS06825	COG0454	-acetyltransferase
D9C18_RS06835	COG5646	InterPro IPR014922
D9C18_RS06840	COG1785	Belongs to the alkaline phosphatase family
D9C18_RS06850	COG1819	glycosyl
D9C18_RS06855	COG1388	LysM domain
D9C18_RS06855	COG3858	chitin binding
D9C18_RS06860	COG1802	Transcriptional regulator
D9C18_RS06865	COG0730	response to heat
D9C18_RS06870	COG2814	Major facilitator Superfamily
D9C18_RS06875	COG1846	Transcriptional regulator
D9C18_RS06880	COG0778	Nitroreductase
D9C18_RS06885	COG2409	Drug exporters of the RND superfamily
D9C18_RS06885	COG1033	growth of symbiont in host cell
D9C18_RS06890	COG1846	Transcriptional regulator
D9C18_RS06895	COG2318	DinB family
D9C18_RS06900	COG1113	amino acid transport
D9C18_RS06905	COG0488	(ABC) transporter
D9C18_RS06910	COG0456	acetyltransferase
D9C18_RS06920	COG1309	transcriptional regulator
D9C18_RS06935	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C18_RS06940	COG2323	membrane
D9C18_RS06965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS06970	COG2259	Doxx family
D9C18_RS06975	COG0346	lactoylglutathione lyase activity
D9C18_RS06980	COG0778	Nitroreductase
D9C18_RS06985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C18_RS06990	COG0789	Transcriptional regulator
D9C18_RS06990	COG4978	Transcriptional regulator
D9C18_RS06995	COG1811	Na channel or pump
D9C18_RS07000	COG0596	Alpha beta hydrolase
D9C18_RS07005	COG2409	Drug exporters of the RND superfamily
D9C18_RS07010	COG2197	response regulator
D9C18_RS07015	COG4585	Histidine kinase
D9C18_RS07030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9C18_RS07035	COG0640	Transcriptional regulator
D9C18_RS07040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9C18_RS07045	COG0076	glutamate decarboxylase activity
D9C18_RS07050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS07055	COG0697	spore germination
D9C18_RS07060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS07070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9C18_RS07075	COG0640	Transcriptional regulator
D9C18_RS07080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS07090	COG3545	Serine hydrolase
D9C18_RS07095	COG2030	dehydratase
D9C18_RS07100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS07105	COG0697	spore germination
D9C18_RS07110	COG1309	transcriptional regulator
D9C18_RS07115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS07130	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D9C18_RS07145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS07150	COG3708	Transcriptional regulator
D9C18_RS07150	COG2207	Transcriptional regulator
D9C18_RS07160	COG2207	Transcriptional regulator
D9C18_RS07160	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS07165	COG0697	spore germination
D9C18_RS07175	COG1329	Transcriptional regulator
D9C18_RS07180	COG1278	Cold shock
D9C18_RS07185	COG0693	protein deglycase activity
D9C18_RS07210	COG1476	TRANSCRIPTIONal
D9C18_RS07220	COG5444	nuclease activity
D9C18_RS07230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS07235	COG0583	DNA-binding transcription factor activity
D9C18_RS07270	COG0457	Tetratricopeptide repeat
D9C18_RS07285	COG0791	NLP P60 protein
D9C18_RS07285	COG0741	lytic transglycosylase activity
D9C18_RS07295	COG5644	endopeptidase inhibitor activity
D9C18_RS07305	COG0433	COG0433 Predicted ATPase
D9C18_RS07345	COG2946	Replication initiation factor
D9C18_RS07350	COG1674	ftsk spoiiie
D9C18_RS07380	COG1396	sequence-specific DNA binding
D9C18_RS07385	COG2856	Zn peptidase
D9C18_RS07390	COG0582	viral genome integration into host DNA
D9C18_RS07430	COG3091	SprT-like family
D9C18_RS07440	COG2183	response to ionizing radiation
D9C18_RS07445	COG1846	Transcriptional regulator
D9C18_RS07450	COG1673	EVE domain
D9C18_RS07465	COG2208	phosphoserine phosphatase activity
D9C18_RS07470	COG1191	sigma factor activity
D9C18_RS07475	COG2172	sigma factor antagonist activity
D9C18_RS07480	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS07485	COG2208	phosphoserine phosphatase activity
D9C18_RS07490	COG2172	sigma factor antagonist activity
D9C18_RS07495	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS07500	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS07505	COG2337	Toxic component of a toxin-antitoxin (TA) module
D9C18_RS07510	COG0864	Transcriptional regulator
D9C18_RS07515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9C18_RS07520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9C18_RS07525	COG0736	holo-[acyl-carrier-protein] synthase activity
D9C18_RS07530	COG0705	Rhomboid family
D9C18_RS07535	COG3428	Bacterial PH domain
D9C18_RS07540	COG3402	PFAM membrane-flanked domain
D9C18_RS07545	COG0513	Belongs to the DEAD box helicase family
D9C18_RS07555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9C18_RS07560	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9C18_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS07570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D9C18_RS07585	COG1960	acyl-CoA dehydrogenase activity
D9C18_RS07595	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C18_RS07600	COG1131	(ABC) transporter
D9C18_RS07605	COG0628	permease
D9C18_RS07610	COG1301	dicarboxylic acid transport
D9C18_RS07615	COG4565	transcriptional regulatory protein
D9C18_RS07620	COG3290	protein histidine kinase activity
D9C18_RS07625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9C18_RS07630	COG3546	catalase activity
D9C18_RS07635	COG2329	Antibiotic biosynthesis monooxygenase
D9C18_RS07640	COG0662	Cupin 2, conserved barrel domain protein
D9C18_RS07645	COG3729	General stress protein
D9C18_RS07650	COG2217	Heavy metal translocating P-type atpase
D9C18_RS07655	COG4876	unkown
D9C18_RS07660	COG2261	transglycosylase associated protein
D9C18_RS07665	COG1914	H( )-stimulated, divalent metal cation uptake system
D9C18_RS07695	COG0028	Belongs to the TPP enzyme family
D9C18_RS07700	COG0494	nUDIX hydrolase
D9C18_RS07705	COG0551	DNA topoisomerase type I activity
D9C18_RS07705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9C18_RS07710	COG1522	sequence-specific DNA binding
D9C18_RS07715	COG2814	Major facilitator Superfamily
D9C18_RS07725	COG3871	stress protein (general stress protein 26)
D9C18_RS07730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS07735	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS07740	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS07745	COG2226	methyltransferase
D9C18_RS07750	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS07755	COG3711	transcriptional antiterminator
D9C18_RS07760	COG4989	oxidoreductase activity
D9C18_RS07765	COG0768	penicillin binding
D9C18_RS07770	COG2329	Antibiotic biosynthesis monooxygenase
D9C18_RS07780	COG2755	lipolytic protein G-D-S-L family
D9C18_RS07785	COG1414	Transcriptional regulator
D9C18_RS07790	COG1984	allophanate hydrolase subunit 2
D9C18_RS07795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9C18_RS07800	COG4336	lyase activity
D9C18_RS07805	COG1914	H( )-stimulated, divalent metal cation uptake system
D9C18_RS07810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9C18_RS07815	COG0561	phosphatase activity
D9C18_RS07825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9C18_RS07835	COG0681	Belongs to the peptidase S26 family
D9C18_RS07840	COG0473	3-isopropylmalate dehydrogenase activity
D9C18_RS07845	COG0246	Mannitol dehydrogenase
D9C18_RS07850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS07855	COG2213	PTS system mannitol-specific
D9C18_RS07865	COG1349	DNA-binding transcription factor activity
D9C18_RS07870	COG1276	copper resistance
D9C18_RS07870	COG2372	response to copper ion
D9C18_RS07875	COG4549	nuclear export factor GLE1
D9C18_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS07885	COG4975	Glucose uptake
D9C18_RS07890	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS07895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9C18_RS07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS07905	COG0640	Transcriptional regulator
D9C18_RS07910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D9C18_RS07915	COG0778	Nitroreductase
D9C18_RS07920	COG1309	transcriptional regulator
D9C18_RS07925	COG2814	Major facilitator Superfamily
D9C18_RS07935	COG4607	ABC-type enterochelin transport system periplasmic component
D9C18_RS07940	COG4604	ABC transporter, ATP-binding protein
D9C18_RS07945	COG4605	iron ion homeostasis
D9C18_RS07950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS07955	COG0527	aspartate kinase activity
D9C18_RS07975	COG0457	Tetratricopeptide repeat
D9C18_RS07980	COG3850	Histidine kinase
D9C18_RS07980	COG5002	protein histidine kinase activity
D9C18_RS07985	COG0745	RESPONSE REGULATOR receiver
D9C18_RS07990	COG0577	efflux transmembrane transporter activity
D9C18_RS07995	COG1136	(ABC) transporter
D9C18_RS08000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D9C18_RS08010	COG0697	spore germination
D9C18_RS08020	COG5434	Belongs to the glycosyl hydrolase 28 family
D9C18_RS08025	COG3104	oligopeptide transport
D9C18_RS08030	COG0596	Alpha beta hydrolase
D9C18_RS08045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9C18_RS08050	COG0163	prenyltransferase activity
D9C18_RS08055	COG0583	DNA-binding transcription factor activity
D9C18_RS08060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C18_RS08065	COG0765	amino acid transport
D9C18_RS08070	COG1126	abc transporter atp-binding protein
D9C18_RS08075	COG2364	Membrane
D9C18_RS08085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9C18_RS08090	COG0697	spore germination
D9C18_RS08100	COG2814	Major facilitator Superfamily
D9C18_RS08105	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D9C18_RS08110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS08115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS08120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS08125	COG1733	regulation of RNA biosynthetic process
D9C18_RS08130	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D9C18_RS08135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D9C18_RS08145	COG3209	COG3209 Rhs family protein
D9C18_RS08155	COG2723	6-phospho-beta-galactosidase activity
D9C18_RS08170	COG1846	Transcriptional regulator
D9C18_RS08180	COG1714	RDD family
D9C18_RS08190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C18_RS08195	COG0765	amino acid transport
D9C18_RS08210	COG1376	ErfK ybiS ycfS ynhG family protein
D9C18_RS08220	COG2223	nitrite transmembrane transporter activity
D9C18_RS08225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C18_RS08230	COG0243	molybdopterin cofactor binding
D9C18_RS08235	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C18_RS08240	COG2146	nitrite reductase [NAD(P)H] activity
D9C18_RS08245	COG1587	Uroporphyrinogen-III synthase
D9C18_RS08245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9C18_RS08250	COG0492	ferredoxin-NADP+ reductase activity
D9C18_RS08255	COG2267	carboxylic ester hydrolase activity
D9C18_RS08260	COG0701	Predicted permease
D9C18_RS08265	COG3689	TIGRFAM TIGR03943 family protein
D9C18_RS08270	COG2508	Transcriptional regulator
D9C18_RS08275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C18_RS08280	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS08285	COG0506	proline dehydrogenase activity
D9C18_RS08290	COG3541	Predicted nucleotidyltransferase
D9C18_RS08295	COG3458	cephalosporin-C deacetylase activity
D9C18_RS08300	COG0583	DNA-binding transcription factor activity
D9C18_RS08305	COG2226	methyltransferase
D9C18_RS08315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D9C18_RS08325	COG1660	Displays ATPase and GTPase activities
D9C18_RS08330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9C18_RS08345	COG3403	YqcI/YcgG family
D9C18_RS08360	COG0039	L-malate dehydrogenase activity
D9C18_RS08375	COG1288	antiporter activity
D9C18_RS08380	COG1473	amidohydrolase
D9C18_RS08385	COG2113	Glycine betaine
D9C18_RS08390	COG4176	ABC-type proline glycine betaine transport system permease component
D9C18_RS08395	COG4175	Glycine betaine
D9C18_RS08395	COG0517	IMP dehydrogenase activity
D9C18_RS08400	COG0640	Transcriptional regulator
D9C18_RS08405	COG2814	Major facilitator Superfamily
D9C18_RS08410	COG0477	Major facilitator Superfamily
D9C18_RS08420	COG3853	Toxic anion resistance protein (TelA)
D9C18_RS08430	COG0861	Integral membrane protein TerC family
D9C18_RS08435	COG2310	stress, protein
D9C18_RS08440	COG2310	stress, protein
D9C18_RS08445	COG2310	stress, protein
D9C18_RS08455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C18_RS08460	COG1121	(ABC) transporter
D9C18_RS08465	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9C18_RS08470	COG0366	Alpha amylase catalytic
D9C18_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS08485	COG1876	peptidase activity
D9C18_RS08490	COG1595	DNA-templated transcription, initiation
D9C18_RS08495	COG1595	DNA-templated transcription, initiation
D9C18_RS08510	COG0667	Aldo Keto reductase
D9C18_RS08515	COG1668	transmembrane transport
D9C18_RS08525	COG3279	Response regulator of the LytR AlgR family
D9C18_RS08535	COG1405	negative regulation of cell septum assembly
D9C18_RS08535	COG3012	SEC-C Motif Domain Protein
D9C18_RS08540	COG1714	RDD family
D9C18_RS08545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D9C18_RS08550	COG0252	asparaginase activity
D9C18_RS08555	COG1309	transcriptional regulator
D9C18_RS08560	COG0477	Major facilitator Superfamily
D9C18_RS08565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9C18_RS08570	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D9C18_RS08575	COG0805	protein transport
D9C18_RS08580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9C18_RS08585	COG3540	Alkaline phosphatase
D9C18_RS08595	COG2304	oxidoreductase activity
D9C18_RS08600	COG3773	Cell wall hydrolase
D9C18_RS08620	COG1131	(ABC) transporter
D9C18_RS08625	COG2205	protein histidine kinase activity
D9C18_RS08630	COG0745	RESPONSE REGULATOR receiver
D9C18_RS08635	COG0697	spore germination
D9C18_RS08645	COG3173	Aminoglycoside phosphotransferase
D9C18_RS08650	COG2721	sulfolactate sulfo-lyase activity
D9C18_RS08655	COG2186	Transcriptional regulator
D9C18_RS08660	COG4948	Mandelate Racemase Muconate Lactonizing
D9C18_RS08665	COG2271	Major facilitator Superfamily
D9C18_RS08670	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS08675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9C18_RS08685	COG0784	Response regulator, receiver
D9C18_RS08690	COG4191	Histidine kinase
D9C18_RS08695	COG2066	Belongs to the glutaminase family
D9C18_RS08710	COG2040	homocysteine
D9C18_RS08715	COG0833	amino acid
D9C18_RS08720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C18_RS08730	COG2188	Transcriptional regulator
D9C18_RS08735	COG0363	glucosamine-6-phosphate deaminase activity
D9C18_RS08740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS08740	COG1263	PTS System
D9C18_RS08740	COG2190	(PTS) system
D9C18_RS08745	COG1301	dicarboxylic acid transport
D9C18_RS08750	COG1054	Belongs to the UPF0176 family
D9C18_RS08755	COG2207	Transcriptional regulator
D9C18_RS08760	COG2312	Erythromycin esterase
D9C18_RS08770	COG0688	phosphatidylethanolamine metabolic process
D9C18_RS08775	COG0586	Pfam SNARE associated Golgi protein
D9C18_RS08780	COG1183	phosphatidylcholine synthase activity
D9C18_RS08785	COG0596	Alpha beta hydrolase
D9C18_RS08795	COG3591	Belongs to the peptidase S1B family
D9C18_RS08800	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9C18_RS08825	COG2207	Transcriptional regulator
D9C18_RS08825	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS08830	COG0697	spore germination
D9C18_RS08835	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS08855	COG0456	acetyltransferase
D9C18_RS08855	COG1846	Transcriptional regulator
D9C18_RS08870	COG2271	Major facilitator Superfamily
D9C18_RS08875	COG0584	glycerophosphoryl diester phosphodiesterase
D9C18_RS08880	COG0531	amino acid
D9C18_RS08890	COG2124	cytochrome p450
D9C18_RS08895	COG2602	Beta-lactamase
D9C18_RS08910	COG1113	amino acid transport
D9C18_RS08925	COG0515	serine threonine protein kinase
D9C18_RS08935	COG0642	Histidine kinase
D9C18_RS08945	COG5609	conserved protein (DUF2294)
D9C18_RS08955	COG0288	reversible hydration of carbon dioxide
D9C18_RS08960	COG3002	Belongs to the UPF0753 family
D9C18_RS08965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9C18_RS08970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9C18_RS08975	COG2169	Transcriptional regulator
D9C18_RS08990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9C18_RS09000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9C18_RS09005	COG4856	YbbR-like protein
D9C18_RS09010	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9C18_RS09015	COG5662	AntiSigma factor
D9C18_RS09020	COG1595	DNA-templated transcription, initiation
D9C18_RS09050	COG1683	Conserved Protein
D9C18_RS09055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS09060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D9C18_RS09065	COG1737	Transcriptional regulator
D9C18_RS09070	COG1263	PTS System
D9C18_RS09070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS09075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9C18_RS09080	COG1472	Belongs to the glycosyl hydrolase 3 family
D9C18_RS09085	COG3876	Protein conserved in bacteria
D9C18_RS09090	COG2207	Transcriptional regulator
D9C18_RS09090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS09095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS09100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS09110	COG2819	hydrolase of the alpha beta superfamily
D9C18_RS09115	COG0385	Bile acid
D9C18_RS09120	COG0659	secondary active sulfate transmembrane transporter activity
D9C18_RS09205	COG0726	polysaccharide deacetylase
D9C18_RS09210	COG2194	sulfuric ester hydrolase activity
D9C18_RS09220	COG0489	protein tyrosine kinase activity
D9C18_RS09225	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS09235	COG2226	methyltransferase
D9C18_RS09245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9C18_RS09250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9C18_RS09255	COG0101	tRNA pseudouridine synthase activity
D9C18_RS09260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D9C18_RS09265	COG1122	ATPase activity
D9C18_RS09270	COG1122	ATPase activity
D9C18_RS09275	COG0203	ribosomal protein L17
D9C18_RS09280	COG0202	RNA polymerase activity
D9C18_RS09285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D9C18_RS09290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9C18_RS09295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9C18_RS09305	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D9C18_RS09310	COG0024	Methionine aminopeptidase
D9C18_RS09315	COG0563	adenylate kinase activity
D9C18_RS09320	COG0201	protein transport
D9C18_RS09325	COG0200	Binds to the 23S rRNA
D9C18_RS09335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9C18_RS09340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D9C18_RS09345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9C18_RS09350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9C18_RS09360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9C18_RS09370	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9C18_RS09375	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9C18_RS09385	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9C18_RS09390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9C18_RS09405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9C18_RS09415	COG0088	Forms part of the polypeptide exit tunnel
D9C18_RS09420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9C18_RS09430	COG0596	Alpha beta hydrolase
D9C18_RS09435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9C18_RS09440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9C18_RS09445	COG0049	tRNA binding
D9C18_RS09450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9C18_RS09455	COG1358	cellular component organization or biogenesis
D9C18_RS09460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9C18_RS09465	COG0085	RNA polymerase activity
D9C18_RS09470	COG2813	Specifically methylates the guanine in position
D9C18_RS09480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9C18_RS09485	COG0081	regulation of translation
D9C18_RS09495	COG0250	Participates in transcription elongation, termination and antitermination
D9C18_RS09500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9C18_RS09510	COG1595	DNA-templated transcription, initiation
D9C18_RS09515	COG3688	RNA-binding protein containing a PIN domain
D9C18_RS09520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9C18_RS09525	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D9C18_RS09530	COG0215	cysteine-tRNA ligase activity
D9C18_RS09535	COG1045	serine acetyltransferase
D9C18_RS09545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9C18_RS09550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D9C18_RS09555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D9C18_RS09560	COG4956	integral membrane protein (PIN domain superfamily)
D9C18_RS09565	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D9C18_RS09570	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D9C18_RS09575	COG0542	response to heat
D9C18_RS09580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D9C18_RS09585	COG3880	PFAM UvrB UvrC protein
D9C18_RS09590	COG4463	regulation of RNA biosynthetic process
D9C18_RS09670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9C18_RS09675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9C18_RS09680	COG1396	sequence-specific DNA binding
D9C18_RS09685	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9C18_RS09690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9C18_RS09695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9C18_RS09700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C18_RS09705	COG0512	Glutamine amidotransferase of anthranilate synthase
D9C18_RS09710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9C18_RS09715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C18_RS09720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9C18_RS09725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9C18_RS09730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9C18_RS09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9C18_RS09740	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D9C18_RS09745	COG0037	tRNA processing
D9C18_RS09755	COG2304	oxidoreductase activity
D9C18_RS09760	COG2208	phosphoserine phosphatase activity
D9C18_RS09775	COG1098	S1 RNA binding domain
D9C18_RS09780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9C18_RS09795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9C18_RS09800	COG3956	TIGRFAM MazG family protein
D9C18_RS09805	COG2244	polysaccharide biosynthetic process
D9C18_RS09810	COG2002	toxin-antitoxin pair type II binding
D9C18_RS09815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9C18_RS09825	COG0193	aminoacyl-tRNA hydrolase activity
D9C18_RS09830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9C18_RS09835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9C18_RS09840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9C18_RS09845	COG2088	sporulation resulting in formation of a cellular spore
D9C18_RS09850	COG0251	oxidation-reduction process
D9C18_RS09855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C18_RS09860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9C18_RS09870	COG4466	Protein conserved in bacteria
D9C18_RS09880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9C18_RS09885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D9C18_RS09890	COG3583	domain protein
D9C18_RS09890	COG3584	3D domain protein
D9C18_RS09895	COG0084	hydrolase, TatD family'
D9C18_RS09900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C18_RS09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C18_RS09905	COG2002	toxin-antitoxin pair type II binding
D9C18_RS09910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9C18_RS09915	COG2827	Endonuclease containing a URI domain
D9C18_RS09920	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D9C18_RS09925	COG4467	Involved in initiation control of chromosome replication
D9C18_RS09930	COG1774	PSP1 C-terminal conserved region
D9C18_RS09935	COG0470	DNA polymerase III
D9C18_RS09940	COG1728	Protein conserved in bacteria
D9C18_RS09945	COG3870	Protein conserved in bacteria
D9C18_RS09950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9C18_RS09955	COG1982	Orn Lys Arg decarboxylase major
D9C18_RS09960	COG3853	Toxic anion resistance protein (TelA)
D9C18_RS09965	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D9C18_RS10010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9C18_RS10015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9C18_RS10020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9C18_RS10030	COG0590	tRNA wobble adenosine to inosine editing
D9C18_RS10035	COG1335	isochorismatase
D9C18_RS10040	COG1388	LysM domain
D9C18_RS10040	COG3858	chitin binding
D9C18_RS10045	COG1428	Deoxynucleoside kinase
D9C18_RS10050	COG1428	Deoxynucleoside kinase
D9C18_RS10060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9C18_RS10065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D9C18_RS10070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D9C18_RS10075	COG1686	Belongs to the peptidase S11 family
D9C18_RS10080	COG0517	IMP dehydrogenase activity
D9C18_RS10080	COG0516	GMP reductase activity
D9C18_RS10115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9C18_RS10120	COG0187	DNA topoisomerase II activity
D9C18_RS10130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9C18_RS10135	COG2501	S4 domain
D9C18_RS10140	COG0592	DNA-directed DNA polymerase activity
D9C18_RS10145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9C18_RS10155	COG0594	ribonuclease P activity
D9C18_RS10160	COG0706	membrane insertase activity
D9C18_RS10165	COG1847	R3H domain protein
D9C18_RS10170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9C18_RS10175	COG0445	tRNA wobble uridine modification
D9C18_RS10180	COG0357	Ribosomal RNA small subunit methyltransferase G
D9C18_RS10185	COG1475	DNA binding
D9C18_RS10195	COG1192	Involved in chromosome partitioning
D9C18_RS10200	COG1475	DNA binding
D9C18_RS10210	COG3949	Membrane
D9C18_RS10215	COG4481	Protein conserved in bacteria
D9C18_RS10220	COG0243	molybdopterin cofactor binding
D9C18_RS10225	COG0012	GTP binding
D9C18_RS10230	COG0360	Binds together with S18 to 16S ribosomal RNA
D9C18_RS10235	COG0629	single-stranded DNA binding
D9C18_RS10240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9C18_RS10245	COG0708	Exodeoxyribonuclease III
D9C18_RS10260	COG0542	response to heat
D9C18_RS10265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C18_RS10270	COG0346	lactoylglutathione lyase activity
D9C18_RS10275	COG2814	Major facilitator Superfamily
D9C18_RS10275	COG0477	Major facilitator Superfamily
D9C18_RS10280	COG1266	CAAX protease self-immunity
D9C18_RS10285	COG1331	Highly conserved protein containing a thioredoxin domain
D9C18_RS10290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D9C18_RS10295	COG1331	Highly conserved protein containing a thioredoxin domain
D9C18_RS10300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C18_RS10305	COG2315	Protein conserved in bacteria
D9C18_RS10310	COG0456	acetyltransferase
D9C18_RS10315	COG2364	Membrane
D9C18_RS10320	COG2153	protein acetylation
D9C18_RS10325	COG1846	Transcriptional regulator
D9C18_RS10340	COG1357	PFAM Pentapeptide repeats (8 copies)
D9C18_RS10345	COG4319	ketosteroid isomerase
D9C18_RS10355	COG4978	Transcriptional regulator
D9C18_RS10355	COG0789	Transcriptional regulator
D9C18_RS10360	COG2271	Major facilitator Superfamily
D9C18_RS10375	COG1227	inorganic diphosphatase activity
D9C18_RS10380	COG1733	regulation of RNA biosynthetic process
D9C18_RS10400	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D9C18_RS10405	COG0359	binds to the 23S rRNA
D9C18_RS10410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D9C18_RS10415	COG2807	transmembrane transport
D9C18_RS10420	COG3093	addiction module antidote protein HigA
D9C18_RS10435	COG0305	Participates in initiation and elongation during chromosome replication
D9C18_RS10440	COG0346	lactoylglutathione lyase activity
D9C18_RS10470	COG0745	RESPONSE REGULATOR receiver
D9C18_RS10475	COG5002	protein histidine kinase activity
D9C18_RS10480	COG4863	YycH protein
D9C18_RS10485	COG4853	Protein conserved in bacteria
D9C18_RS10490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9C18_RS10495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C18_RS10510	COG3829	transcription factor binding
D9C18_RS10515	COG0640	Transcriptional regulator
D9C18_RS10520	COG5658	integral membrane protein
D9C18_RS10540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9C18_RS10545	COG0833	amino acid
D9C18_RS10550	COG0010	Belongs to the arginase family
D9C18_RS10560	COG0457	Tetratricopeptide repeat
D9C18_RS10565	COG0456	acetyltransferase
D9C18_RS10570	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
D9C18_RS10590	COG1063	alcohol dehydrogenase
D9C18_RS10605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9C18_RS10660	COG2963	transposase activity
D9C18_RS10690	COG0210	DNA helicase
D9C18_RS10725	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C18_RS10740	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D9C18_RS10745	COG1131	(ABC) transporter
D9C18_RS10755	COG2188	Transcriptional regulator
D9C18_RS10770	COG2723	6-phospho-beta-galactosidase activity
D9C18_RS10775	COG3634	alkyl hydroperoxide reductase activity
D9C18_RS10780	COG0450	alkyl hydroperoxide reductase
D9C18_RS10785	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9C18_RS10790	COG2610	gluconate transmembrane transporter activity
D9C18_RS10795	COG1070	Carbohydrate kinase
D9C18_RS10800	COG1802	Transcriptional regulator
D9C18_RS10805	COG1929	Belongs to the glycerate kinase type-1 family
D9C18_RS10810	COG5039	Polysaccharide pyruvyl transferase
D9C18_RS10815	COG1346	cytolysis
D9C18_RS10820	COG1380	Effector of murein hydrolase LrgA
D9C18_RS10825	COG1846	Transcriptional regulator
D9C18_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS10835	COG1309	transcriptional regulator
D9C18_RS10840	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS10905	COG0326	Molecular chaperone. Has ATPase activity
D9C18_RS10935	COG0667	Aldo Keto reductase
D9C18_RS10940	COG1349	DNA-binding transcription factor activity
D9C18_RS10960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C18_RS10965	COG3962	Belongs to the TPP enzyme family
D9C18_RS10970	COG1082	Xylose isomerase domain protein TIM barrel
D9C18_RS10975	COG2814	Major facilitator Superfamily
D9C18_RS10980	COG0673	inositol 2-dehydrogenase activity
D9C18_RS10985	COG1082	Xylose isomerase domain protein TIM barrel
D9C18_RS10990	COG1082	Xylose isomerase domain protein TIM barrel
D9C18_RS10995	COG0191	fructose-bisphosphate aldolase activity
D9C18_RS11000	COG0745	RESPONSE REGULATOR receiver
D9C18_RS11005	COG2205	protein histidine kinase activity
D9C18_RS11020	COG5294	Protein conserved in bacteria
D9C18_RS11025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS11055	COG0561	phosphatase activity
D9C18_RS11060	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D9C18_RS11065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C18_RS11070	COG0456	acetyltransferase
D9C18_RS11075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C18_RS11080	COG0765	amino acid transport
D9C18_RS11085	COG1126	abc transporter atp-binding protein
D9C18_RS11090	COG1473	amidohydrolase
D9C18_RS11095	COG2079	MmgE PrpD family protein
D9C18_RS11100	COG3192	ethanolamine utilization protein
D9C18_RS11110	COG2390	Transcriptional regulator
D9C18_RS11115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9C18_RS11120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C18_RS11125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D9C18_RS11140	COG3507	Belongs to the glycosyl hydrolase 43 family
D9C18_RS11145	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D9C18_RS11150	COG0494	nUDIX hydrolase
D9C18_RS11170	COG5444	nuclease activity
D9C18_RS11190	COG2190	(PTS) system
D9C18_RS11190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS11190	COG1263	PTS System
D9C18_RS11200	COG0589	response to stress
D9C18_RS11215	COG0697	spore germination
D9C18_RS11335	COG2755	lipolytic protein G-D-S-L family
D9C18_RS11335	COG3401	FG-GAP repeat protein
D9C18_RS11340	COG0513	Belongs to the DEAD box helicase family
D9C18_RS11345	COG2270	Major facilitator Superfamily
D9C18_RS11360	COG3711	transcriptional antiterminator
D9C18_RS11365	COG2273	Hydrolase Family 16
D9C18_RS11370	COG2851	Citrate transporter
D9C18_RS11375	COG0693	protein deglycase activity
D9C18_RS11375	COG0753	catalase activity
D9C18_RS11390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C18_RS11395	COG0500	methyltransferase
D9C18_RS11400	COG2610	gluconate transmembrane transporter activity
D9C18_RS11405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9C18_RS11410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9C18_RS11415	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS11420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C18_RS11425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9C18_RS11430	COG4894	glucomannan catabolic process
D9C18_RS11440	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9C18_RS11445	COG2197	response regulator
D9C18_RS11450	COG4585	Histidine kinase
D9C18_RS11460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9C18_RS11470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS11475	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS11480	COG2508	Transcriptional regulator
D9C18_RS11485	COG3842	ATPase activity
D9C18_RS11490	COG0726	polysaccharide deacetylase
D9C18_RS11500	COG0501	Belongs to the peptidase M48B family
D9C18_RS11505	COG3493	citrate carrier protein
D9C18_RS11510	COG1271	oxidase subunit
D9C18_RS11515	COG1294	oxidase, subunit
D9C18_RS11520	COG4988	ABC transporter
D9C18_RS11525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D9C18_RS11530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9C18_RS11535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D9C18_RS11540	COG1595	DNA-templated transcription, initiation
D9C18_RS11560	COG1131	(ABC) transporter
D9C18_RS11565	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9C18_RS11570	COG2814	Major facilitator Superfamily
D9C18_RS11575	COG0753	catalase activity
D9C18_RS11580	COG2094	Belongs to the DNA glycosylase MPG family
D9C18_RS11590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS11590	COG3711	transcriptional antiterminator
D9C18_RS11595	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C18_RS11600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C18_RS11605	COG1447	Phosphotransferase system cellobiose-specific component IIA
D9C18_RS11615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9C18_RS11625	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D9C18_RS11630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9C18_RS11635	COG1696	Membrane protein involved in D-alanine export
D9C18_RS11640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS11660	COG1575	Belongs to the MenA family. Type 1 subfamily
D9C18_RS11670	COG2357	RelA SpoT domain protein
D9C18_RS11675	COG2234	aminopeptidase activity
D9C18_RS11680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9C18_RS11685	COG1846	Transcriptional regulator
D9C18_RS11690	COG5522	Integral membrane protein (intg_mem_TP0381)
D9C18_RS11695	COG1442	glycosyl transferase family 8
D9C18_RS11700	COG3711	transcriptional antiterminator
D9C18_RS11705	COG1263	PTS System
D9C18_RS11705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS11715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D9C18_RS11725	COG0346	lactoylglutathione lyase activity
D9C18_RS11730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9C18_RS11735	COG4895	conserved protein (DUF2196)
D9C18_RS11740	COG2814	Major facilitator Superfamily
D9C18_RS11745	COG1346	cytolysis
D9C18_RS11750	COG1380	Effector of murein hydrolase LrgA
D9C18_RS11755	COG0583	DNA-binding transcription factor activity
D9C18_RS11760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D9C18_RS11765	COG0352	thiamine-phosphate diphosphorylase activity
D9C18_RS11770	COG0672	)-iron permease
D9C18_RS11775	COG2822	iron ion transport
D9C18_RS11780	COG2837	iron assimilation
D9C18_RS11785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D9C18_RS11790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C18_RS11795	COG3162	membrane
D9C18_RS11805	COG1309	transcriptional regulator
D9C18_RS11810	COG2246	polysaccharide biosynthetic process
D9C18_RS11815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D9C18_RS11820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D9C18_RS11825	COG2261	transglycosylase associated protein
D9C18_RS11830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9C18_RS11835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9C18_RS11840	COG1845	cytochrome c oxidase, subunit III
D9C18_RS11845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9C18_RS11860	COG0772	Belongs to the SEDS family
D9C18_RS11865	COG0778	Nitroreductase
D9C18_RS11870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C18_RS11875	COG1404	Belongs to the peptidase S8 family
D9C18_RS11890	COG2116	formate transmembrane transporter activity
D9C18_RS11895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS11895	COG1263	PTS System
D9C18_RS11900	COG1621	beta-fructofuranosidase activity
D9C18_RS11910	COG0351	phosphomethylpyrimidine kinase
D9C18_RS11915	COG1216	Glycosyl transferase, family 2
D9C18_RS11920	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9C18_RS11925	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS11935	COG2233	PERMEase
D9C18_RS11940	COG2363	Small membrane protein
D9C18_RS11955	COG0463	Glycosyl transferase, family 2
D9C18_RS11960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C18_RS11965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C18_RS11970	COG0456	acetyltransferase
D9C18_RS11975	COG2089	acid synthase
D9C18_RS11980	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9C18_RS11985	COG3980	spore coat polysaccharide biosynthesis protein
D9C18_RS11990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D9C18_RS11995	COG1088	dTDP-glucose 4,6-dehydratase activity
D9C18_RS12000	COG1091	dTDP-4-dehydrorhamnose reductase activity
D9C18_RS12005	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D9C18_RS12015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C18_RS12020	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS12025	COG4187	Peptidase family M20/M25/M40
D9C18_RS12030	COG0833	amino acid
D9C18_RS12035	COG2814	Major facilitator Superfamily
D9C18_RS12040	COG0077	Prephenate dehydratase
D9C18_RS12045	COG1917	Cupin 2, conserved barrel domain protein
D9C18_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS12055	COG0151	Belongs to the GarS family
D9C18_RS12060	COG2814	Major facilitator Superfamily
D9C18_RS12065	COG0436	Aminotransferase
D9C18_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS12075	COG3253	May function as heme-dependent peroxidase
D9C18_RS12080	COG0280	phosphate acetyltransferase
D9C18_RS12085	COG0583	DNA-binding transcription factor activity
D9C18_RS12090	COG0095	Lipoate-protein ligase
D9C18_RS12095	COG0697	spore germination
D9C18_RS12105	COG4844	belongs to the
D9C18_RS12110	COG1078	dGTPase activity
D9C18_RS12115	COG3465	dGTPase activity
D9C18_RS12120	COG1959	2 iron, 2 sulfur cluster binding
D9C18_RS12125	COG0477	Major facilitator Superfamily
D9C18_RS12135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9C18_RS12140	COG1846	Transcriptional regulator
D9C18_RS12145	COG1942	4-Oxalocrotonate Tautomerase
D9C18_RS12150	COG1994	Peptidase M50
D9C18_RS12165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C18_RS12170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9C18_RS12175	COG0010	Belongs to the arginase family
D9C18_RS12180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9C18_RS12190	COG0457	Tetratricopeptide repeat
D9C18_RS12200	COG3391	amine dehydrogenase activity
D9C18_RS12205	COG3391	amine dehydrogenase activity
D9C18_RS12215	COG0612	Peptidase, M16
D9C18_RS12220	COG0612	Peptidase, M16
D9C18_RS12225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D9C18_RS12230	COG1131	(ABC) transporter
D9C18_RS12240	COG0535	radical SAM domain protein
D9C18_RS12255	COG4506	Protein conserved in bacteria
D9C18_RS12260	COG0018	arginyl-trna synthetase
D9C18_RS12265	COG2223	nitrite transmembrane transporter activity
D9C18_RS12270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9C18_RS12280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9C18_RS12285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D9C18_RS12290	COG1140	nitrate reductase beta subunit
D9C18_RS12295	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D9C18_RS12300	COG2181	nitrate reductase activity
D9C18_RS12310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C18_RS12320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C18_RS12330	COG4294	response to UV
D9C18_RS12335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C18_RS12340	COG0247	lactate metabolic process
D9C18_RS12340	COG2181	nitrate reductase activity
D9C18_RS12345	COG1960	acyl-CoA dehydrogenase activity
D9C18_RS12350	COG3343	RNA polymerase activity
D9C18_RS12355	COG0504	CTP synthase activity
D9C18_RS12360	COG4821	SIS domain
D9C18_RS12365	COG2204	response regulator
D9C18_RS12370	COG0191	fructose-bisphosphate aldolase activity
D9C18_RS12375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D9C18_RS12380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9C18_RS12385	COG1494	fructose-1,6-bisphosphatase
D9C18_RS12395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9C18_RS12405	COG1435	thymidine kinase activity
D9C18_RS12410	COG0281	malic enzyme
D9C18_RS12415	COG0679	Auxin Efflux Carrier
D9C18_RS12420	COG0789	Transcriptional regulator
D9C18_RS12425	COG0346	lactoylglutathione lyase activity
D9C18_RS12430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9C18_RS12435	COG2890	protein-(glutamine-N5) methyltransferase activity
D9C18_RS12455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9C18_RS12460	COG0009	L-threonylcarbamoyladenylate synthase
D9C18_RS12465	COG1971	Probably functions as a manganese efflux pump
D9C18_RS12470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9C18_RS12475	COG0698	ribose 5-phosphate isomerase
D9C18_RS12480	COG4475	Protein of unknown function (DUF436)
D9C18_RS12485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9C18_RS12490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9C18_RS12500	COG0356	it plays a direct role in the translocation of protons across the membrane
D9C18_RS12510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9C18_RS12515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9C18_RS12520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9C18_RS12525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9C18_RS12530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9C18_RS12535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9C18_RS12545	COG4836	Membrane
D9C18_RS12555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9C18_RS12560	COG2385	sporulation resulting in formation of a cellular spore
D9C18_RS12565	COG2304	oxidoreductase activity
D9C18_RS12575	COG2304	oxidoreductase activity
D9C18_RS12585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9C18_RS12590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9C18_RS12600	COG0457	Tetratricopeptide repeat
D9C18_RS12605	COG1994	Peptidase M50
D9C18_RS12610	COG3237	CsbD-like
D9C18_RS12625	COG0831	urea catabolic process
D9C18_RS12630	COG0832	Belongs to the urease beta subunit family
D9C18_RS12635	COG0804	urea catabolic process
D9C18_RS12640	COG1959	2 iron, 2 sulfur cluster binding
D9C18_RS12645	COG2910	NAD(P)H-binding
D9C18_RS12655	COG0789	Transcriptional regulator
D9C18_RS12660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9C18_RS12670	COG2089	acid synthase
D9C18_RS12680	COG1247	-acetyltransferase
D9C18_RS12685	COG0739	heme binding
D9C18_RS12695	COG0671	phosphoesterase, PA-phosphatase related
D9C18_RS12700	COG0347	Belongs to the P(II) protein family
D9C18_RS12705	COG0004	ammonium transporteR
D9C18_RS12715	COG1335	isochorismatase
D9C18_RS12720	COG0477	Major facilitator Superfamily
D9C18_RS12725	COG1953	Uracil, thiamine, allantoin
D9C18_RS12730	COG3420	alginic acid biosynthetic process
D9C18_RS12735	COG2814	Major facilitator Superfamily
D9C18_RS12740	COG1846	Transcriptional regulator
D9C18_RS12750	COG1609	Transcriptional regulator
D9C18_RS12755	COG1077	Cell shape determining protein MreB Mrl
D9C18_RS12760	COG4786	Flagellar basal body rod
D9C18_RS12765	COG4786	Flagellar basal body rod
D9C18_RS12770	COG0457	Tetratricopeptide repeat
D9C18_RS12775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9C18_RS12780	COG1970	mechanosensitive ion channel activity
D9C18_RS12785	COG0745	RESPONSE REGULATOR receiver
D9C18_RS12785	COG2972	Histidine kinase
D9C18_RS12795	COG3764	Sortase (surface protein transpeptidase)
D9C18_RS12810	COG0629	single-stranded DNA binding
D9C18_RS12815	COG1349	DNA-binding transcription factor activity
D9C18_RS12820	COG0561	phosphatase activity
D9C18_RS12830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9C18_RS12835	COG4715	Zinc finger, swim domain protein
D9C18_RS12845	COG3944	biosynthesis protein
D9C18_RS12850	COG0489	protein tyrosine kinase activity
D9C18_RS12855	COG4464	protein tyrosine phosphatase activity
D9C18_RS12860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C18_RS12885	COG5444	nuclease activity
D9C18_RS12915	COG0583	DNA-binding transcription factor activity
D9C18_RS12920	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9C18_RS12930	COG2059	Chromate
D9C18_RS12935	COG2059	Chromate
D9C18_RS12940	COG1522	sequence-specific DNA binding
D9C18_RS12945	COG0405	Gamma-glutamyltransferase
D9C18_RS12955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9C18_RS12965	COG5337	Spore coat protein CotH
D9C18_RS12980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9C18_RS12985	COG0583	DNA-binding transcription factor activity
D9C18_RS12990	COG0028	Belongs to the TPP enzyme family
D9C18_RS12995	COG3527	Alpha-acetolactate decarboxylase
D9C18_RS13000	COG2249	NAD(P)H dehydrogenase (quinone) activity
D9C18_RS13010	COG3103	Sh3 type 3 domain protein
D9C18_RS13015	COG1879	ABC-type sugar transport system periplasmic component
D9C18_RS13020	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9C18_RS13025	COG1129	ABC transporter
D9C18_RS13030	COG1869	D-ribose catabolic process
D9C18_RS13035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C18_RS13040	COG1609	Transcriptional regulator
D9C18_RS13050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9C18_RS13060	COG2843	Capsule synthesis protein
D9C18_RS13070	COG0791	NLP P60 protein
D9C18_RS13075	COG0561	phosphatase activity
D9C18_RS13080	COG1316	TRANSCRIPTIONal
D9C18_RS13095	COG0814	amino acid
D9C18_RS13100	COG0697	spore germination
D9C18_RS13105	COG1482	cell wall glycoprotein biosynthetic process
D9C18_RS13110	COG4193	domain, Protein
D9C18_RS13115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C18_RS13120	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9C18_RS13125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9C18_RS13130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C18_RS13135	COG0463	Glycosyl transferase, family 2
D9C18_RS13135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D9C18_RS13150	COG1682	transport, permease protein
D9C18_RS13155	COG1134	teichoic acid transport
D9C18_RS13165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C18_RS13170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D9C18_RS13200	COG2247	cell wall binding repeat
D9C18_RS13200	COG2385	sporulation resulting in formation of a cellular spore
D9C18_RS13205	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS13205	COG2247	cell wall binding repeat
D9C18_RS13220	COG2244	polysaccharide biosynthetic process
D9C18_RS13225	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS13225	COG0297	glycogen (starch) synthase activity
D9C18_RS13230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C18_RS13240	COG3307	-O-antigen
D9C18_RS13245	COG3206	protein involved in exopolysaccharide biosynthesis
D9C18_RS13250	COG1215	transferase activity, transferring glycosyl groups
D9C18_RS13255	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS13260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9C18_RS13270	COG1131	(ABC) transporter
D9C18_RS13305	COG1316	TRANSCRIPTIONal
D9C18_RS13310	COG1739	Uncharacterized protein family UPF0029
D9C18_RS13315	COG4585	Histidine kinase
D9C18_RS13320	COG2197	response regulator
D9C18_RS13325	COG1307	EDD domain protein, DegV family
D9C18_RS13330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D9C18_RS13340	COG1040	competence protein
D9C18_RS13350	COG2747	anti-sigma28 factor FlgM
D9C18_RS13355	COG3418	PFAM FlgN family protein
D9C18_RS13360	COG4786	Flagellar basal body rod
D9C18_RS13360	COG1256	bacterial-type flagellum assembly
D9C18_RS13365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C18_RS13375	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D9C18_RS13380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9C18_RS13385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C18_RS13390	COG1334	flagellar protein FlaG
D9C18_RS13395	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9C18_RS13400	COG1516	flagellar protein fliS
D9C18_RS13415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9C18_RS13420	COG0653	protein targeting
D9C18_RS13430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS13435	COG2010	Cytochrome c
D9C18_RS13440	COG2884	Cell division ATP-binding protein ftsE
D9C18_RS13445	COG2177	Part of the ABC transporter FtsEX involved in
D9C18_RS13450	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS13450	COG0793	Belongs to the peptidase S41A family
D9C18_RS13460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C18_RS13465	COG2814	Major facilitator Superfamily
D9C18_RS13470	COG1309	transcriptional regulator
D9C18_RS13475	COG3848	Pyruvate phosphate dikinase
D9C18_RS13475	COG0574	Belongs to the PEP-utilizing enzyme family
D9C18_RS13480	COG4897	Protein conserved in bacteria
D9C18_RS13485	COG0556	nucleotide-excision repair
D9C18_RS13490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9C18_RS13495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9C18_RS13510	COG3595	metallopeptidase activity
D9C18_RS13515	COG1983	PspC domain protein
D9C18_RS13520	COG1950	PFAM Membrane protein of
D9C18_RS13535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9C18_RS13540	COG2188	Transcriptional regulator
D9C18_RS13545	COG0363	glucosamine-6-phosphate deaminase activity
D9C18_RS13550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9C18_RS13555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D9C18_RS13560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9C18_RS13565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D9C18_RS13570	COG0546	phosphoglycolate phosphatase activity
D9C18_RS13585	COG5297	Belongs to the glycosyl hydrolase family 6
D9C18_RS13590	COG4990	cell redox homeostasis
D9C18_RS13595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9C18_RS13600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9C18_RS13605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9C18_RS13610	COG0131	Imidazoleglycerol-phosphate dehydratase
D9C18_RS13615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9C18_RS13620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9C18_RS13625	COG0107	imidazoleglycerol-phosphate synthase activity
D9C18_RS13630	COG0140	phosphoribosyl-ATP diphosphatase activity
D9C18_RS13630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9C18_RS13650	COG1132	(ABC) transporter
D9C18_RS13655	COG0457	Tetratricopeptide repeat
D9C18_RS13660	COG0791	NLP P60 protein
D9C18_RS13660	COG3883	PFAM NLP P60 protein
D9C18_RS13665	COG0492	ferredoxin-NADP+ reductase activity
D9C18_RS13670	COG1051	belongs to the nudix hydrolase family
D9C18_RS13675	COG1660	Displays ATPase and GTPase activities
D9C18_RS13680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D9C18_RS13685	COG1481	regulation of sporulation
D9C18_RS13690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS13695	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D9C18_RS13705	COG0745	RESPONSE REGULATOR receiver
D9C18_RS13710	COG5002	protein histidine kinase activity
D9C18_RS13715	COG1136	(ABC) transporter
D9C18_RS13720	COG0577	efflux transmembrane transporter activity
D9C18_RS13725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9C18_RS13730	COG0288	reversible hydration of carbon dioxide
D9C18_RS13735	COG0659	secondary active sulfate transmembrane transporter activity
D9C18_RS13745	COG1611	Belongs to the LOG family
D9C18_RS13750	COG1609	Transcriptional regulator
D9C18_RS13760	COG2182	Extracellular solute-binding protein
D9C18_RS13765	COG1175	transmembrane transport
D9C18_RS13770	COG3833	ABC-type maltose transport systems, permease component
D9C18_RS13775	COG5521	maltodextrose utilization protein MalA
D9C18_RS13780	COG1554	hydrolase, family 65, central catalytic
D9C18_RS13785	COG0366	Alpha amylase catalytic
D9C18_RS13790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9C18_RS13795	COG0740	serine-type endopeptidase activity
D9C18_RS13805	COG4974	Belongs to the 'phage' integrase family
D9C18_RS13905	COG0582	viral genome integration into host DNA
D9C18_RS13985	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C18_RS14020	COG1388	LysM domain
D9C18_RS14020	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS14020	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS14040	COG1674	ftsk spoiiie
D9C18_RS14060	COG2076	Multidrug Resistance protein
D9C18_RS14065	COG2076	Multidrug Resistance protein
D9C18_RS14070	COG1309	transcriptional regulator
D9C18_RS14075	COG0531	amino acid
D9C18_RS14080	COG1621	beta-fructofuranosidase activity
D9C18_RS14085	COG1621	beta-fructofuranosidase activity
D9C18_RS14095	COG1794	racemase activity, acting on amino acids and derivatives
D9C18_RS14110	COG3479	Phenolic acid decarboxylase
D9C18_RS14120	COG2272	Belongs to the type-B carboxylesterase lipase family
D9C18_RS14125	COG1396	sequence-specific DNA binding
D9C18_RS14130	COG3944	biosynthesis protein
D9C18_RS14135	COG0489	protein tyrosine kinase activity
D9C18_RS14140	COG1086	Polysaccharide biosynthesis protein
D9C18_RS14145	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS14150	COG1215	transferase activity, transferring glycosyl groups
D9C18_RS14155	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS14165	COG1216	Glycosyl transferase, family 2
D9C18_RS14170	COG5039	Polysaccharide pyruvyl transferase
D9C18_RS14175	COG1216	Glycosyl transferase, family 2
D9C18_RS14180	COG2244	polysaccharide biosynthetic process
D9C18_RS14185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9C18_RS14190	COG0110	maltose O-acetyltransferase activity
D9C18_RS14195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9C18_RS14200	COG5039	Polysaccharide pyruvyl transferase
D9C18_RS14210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9C18_RS14215	COG1620	l-lactate permease
D9C18_RS14220	COG2186	Transcriptional regulator
D9C18_RS14225	COG1609	Transcriptional regulator
D9C18_RS14230	COG2182	Extracellular solute-binding protein
D9C18_RS14235	COG1175	transmembrane transport
D9C18_RS14240	COG3833	ABC-type maltose transport systems, permease component
D9C18_RS14245	COG1874	Beta-galactosidase
D9C18_RS14250	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D9C18_RS14255	COG2208	phosphoserine phosphatase activity
D9C18_RS14260	COG0596	Alpha beta hydrolase
D9C18_RS14280	COG1131	(ABC) transporter
D9C18_RS14285	COG0842	Transport permease protein
D9C18_RS14290	COG4585	Histidine kinase
D9C18_RS14295	COG2197	response regulator
D9C18_RS14300	COG0247	lactate metabolic process
D9C18_RS14305	COG1139	Iron-sulfur cluster binding protein
D9C18_RS14310	COG1556	Lactate utilization protein
D9C18_RS14320	COG1113	amino acid transport
D9C18_RS14325	COG0697	spore germination
D9C18_RS14330	COG0583	DNA-binding transcription factor activity
D9C18_RS14340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9C18_RS14345	COG1609	Transcriptional regulator
D9C18_RS14350	COG2814	Major facilitator Superfamily
D9C18_RS14355	COG2390	Transcriptional regulator
D9C18_RS14360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9C18_RS14365	COG0126	phosphoglycerate kinase activity
D9C18_RS14370	COG0149	triose-phosphate isomerase activity
D9C18_RS14375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9C18_RS14380	COG0148	phosphopyruvate hydratase activity
D9C18_RS14385	COG0456	acetyltransferase
D9C18_RS14390	COG4640	response to antibiotic
D9C18_RS14395	COG3064	Membrane
D9C18_RS14405	COG2095	MarC family integral membrane protein
D9C18_RS14410	COG1510	regulation of RNA biosynthetic process
D9C18_RS14415	COG1125	glycine betaine transport
D9C18_RS14415	COG0517	IMP dehydrogenase activity
D9C18_RS14420	COG1174	glycine betaine transport
D9C18_RS14425	COG1732	Glycine betaine
D9C18_RS14430	COG1174	glycine betaine transport
D9C18_RS14435	COG1510	regulation of RNA biosynthetic process
D9C18_RS14445	COG1174	glycine betaine transport
D9C18_RS14450	COG1732	Glycine betaine
D9C18_RS14455	COG1174	glycine betaine transport
D9C18_RS14460	COG0840	transmembrane signaling receptor activity
D9C18_RS14465	COG1733	regulation of RNA biosynthetic process
D9C18_RS14470	COG1396	sequence-specific DNA binding
D9C18_RS14475	COG1396	sequence-specific DNA binding
D9C18_RS14480	COG1476	TRANSCRIPTIONal
D9C18_RS14485	COG0596	Alpha beta hydrolase
D9C18_RS14490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9C18_RS14495	COG1647	Serine aminopeptidase, S33
D9C18_RS14500	COG0557	exoribonuclease II activity
D9C18_RS14505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9C18_RS14730	COG3942	CHAP domain
D9C18_RS14730	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C18_RS14755	COG4824	toxin secretion phage lysis holin
D9C18_RS14760	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS14760	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS14775	COG5444	nuclease activity
D9C18_RS14785	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS14790	COG1309	transcriptional regulator
D9C18_RS14795	COG2076	Multidrug Resistance protein
D9C18_RS14805	COG1289	transmembrane transporter activity
D9C18_RS14815	COG0673	inositol 2-dehydrogenase activity
D9C18_RS14820	COG1937	Protein conserved in bacteria
D9C18_RS14825	COG2608	mercury ion transmembrane transporter activity
D9C18_RS14830	COG2217	Heavy metal translocating P-type atpase
D9C18_RS14835	COG2217	Heavy metal translocating P-type atpase
D9C18_RS14840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9C18_RS14845	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D9C18_RS14850	COG2860	membrane
D9C18_RS14860	COG3973	AAA domain
D9C18_RS14865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9C18_RS14870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9C18_RS14875	COG0025	NhaP-type Na H and K H
D9C18_RS14885	COG0656	L-ascorbic acid biosynthetic process
D9C18_RS14890	COG4149	molybdate abc transporter
D9C18_RS14895	COG0725	ABC transporter, periplasmic molybdate-binding protein
D9C18_RS14900	COG1910	domain protein
D9C18_RS14905	COG1368	sulfuric ester hydrolase activity
D9C18_RS14910	COG1988	membrane-bound metal-dependent
D9C18_RS14925	COG0531	amino acid
D9C18_RS14935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS14940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS14945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS14950	COG1120	ATPase activity
D9C18_RS14955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9C18_RS14960	COG1136	(ABC) transporter
D9C18_RS14965	COG0577	efflux transmembrane transporter activity
D9C18_RS14975	COG2140	Oxalate decarboxylase
D9C18_RS14995	COG0745	RESPONSE REGULATOR receiver
D9C18_RS15000	COG2205	protein histidine kinase activity
D9C18_RS15005	COG3386	PFAM SMP-30 Gluconolaconase
D9C18_RS15010	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS15015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9C18_RS15020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9C18_RS15025	COG1120	ATPase activity
D9C18_RS15030	COG2096	Adenosyltransferase
D9C18_RS15035	COG2814	Major facilitator Superfamily
D9C18_RS15040	COG4758	membrane
D9C18_RS15045	COG1842	Phage shock protein A
D9C18_RS15050	COG3595	metallopeptidase activity
D9C18_RS15055	COG4758	membrane
D9C18_RS15060	COG4585	Histidine kinase
D9C18_RS15065	COG2197	response regulator
D9C18_RS15075	COG0814	amino acid
D9C18_RS15080	COG0697	spore germination
D9C18_RS15090	COG0114	fumarate hydratase activity
D9C18_RS15095	COG1309	transcriptional regulator
D9C18_RS15105	COG2205	protein histidine kinase activity
D9C18_RS15105	COG2770	Histidine kinase
D9C18_RS15110	COG0745	RESPONSE REGULATOR receiver
D9C18_RS15115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9C18_RS15120	COG0783	Belongs to the Dps family
D9C18_RS15170	COG1131	(ABC) transporter
D9C18_RS15190	COG1120	ATPase activity
D9C18_RS15200	COG0583	DNA-binding transcription factor activity
D9C18_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS15210	COG1942	4-Oxalocrotonate Tautomerase
D9C18_RS15215	COG0477	Major facilitator Superfamily
D9C18_RS15220	COG1846	Transcriptional regulator
D9C18_RS15225	COG5577	PFAM Coat F domain
D9C18_RS15245	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9C18_RS15245	COG1024	Enoyl-CoA hydratase
D9C18_RS15250	COG0183	Belongs to the thiolase family
D9C18_RS15255	COG1960	acyl-CoA dehydrogenase activity
D9C18_RS15260	COG1393	Belongs to the ArsC family
D9C18_RS15265	COG0509	glycine decarboxylation via glycine cleavage system
D9C18_RS15275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D9C18_RS15280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS15290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9C18_RS15295	COG2011	ABC-type metal ion transport system permease component
D9C18_RS15300	COG1464	Belongs to the NlpA lipoprotein family
D9C18_RS15320	COG0396	ATPase activity
D9C18_RS15325	COG0719	Fe-S assembly protein
D9C18_RS15330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9C18_RS15335	COG0822	iron-sulfur transferase activity
D9C18_RS15340	COG0719	Fe-S assembly protein
D9C18_RS15345	COG0640	Transcriptional regulator
D9C18_RS15350	COG0346	lactoylglutathione lyase activity
D9C18_RS15365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9C18_RS15370	COG0322	excinuclease ABC activity
D9C18_RS15375	COG2222	sugar isomerase
D9C18_RS15380	COG1653	transport
D9C18_RS15385	COG1175	transmembrane transport
D9C18_RS15395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C18_RS15400	COG2188	Transcriptional regulator
D9C18_RS15405	COG3842	ATPase activity
D9C18_RS15410	COG2356	endonuclease I
D9C18_RS15420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C18_RS15425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D9C18_RS15430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9C18_RS15435	COG2068	MobA-Related Protein
D9C18_RS15440	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9C18_RS15445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9C18_RS15450	COG2080	2 iron, 2 sulfur cluster binding
D9C18_RS15460	COG2351	hydroxyisourate hydrolase activity
D9C18_RS15465	COG3195	allantoin biosynthetic process
D9C18_RS15465	COG3648	Uricase
D9C18_RS15470	COG2233	PERMEase
D9C18_RS15475	COG2233	PERMEase
D9C18_RS15480	COG2508	Transcriptional regulator
D9C18_RS15485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9C18_RS15495	COG1801	Protein of unknown function DUF72
D9C18_RS15500	COG0730	response to heat
D9C18_RS15505	COG0737	Belongs to the 5'-nucleotidase family
D9C18_RS15510	COG3377	Domain of unknown function (DUF1805)
D9C18_RS15520	COG0739	heme binding
D9C18_RS15525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9C18_RS15535	COG4470	Protein conserved in bacteria
D9C18_RS15540	COG2445	Protein of unknown function DUF86
D9C18_RS15545	COG0647	UMP catabolic process
D9C18_RS15550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9C18_RS15555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C18_RS15560	COG0460	homoserine dehydrogenase
D9C18_RS15565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9C18_RS15570	COG0083	homoserine kinase activity
D9C18_RS15575	COG1506	peptidase
D9C18_RS15575	COG0823	Involved in the tonB-independent uptake of proteins
D9C18_RS15575	COG4946	Tricorn protease homolog
D9C18_RS15580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9C18_RS15585	COG4837	Protein of unknown function (DUF1462)
D9C18_RS15590	COG1252	NADH dehydrogenase
D9C18_RS15595	COG4844	belongs to the
D9C18_RS15600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D9C18_RS15605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9C18_RS15610	COG0316	Belongs to the HesB IscA family
D9C18_RS15615	COG4974	Belongs to the 'phage' integrase family
D9C18_RS15625	COG0582	viral genome integration into host DNA
D9C18_RS15725	COG0456	acetyltransferase
D9C18_RS15730	COG2808	Putative FMN-binding domain
D9C18_RS15735	COG0516	GMP reductase activity
D9C18_RS15745	COG0492	ferredoxin-NADP+ reductase activity
D9C18_RS15750	COG1252	NADH dehydrogenase
D9C18_RS15765	COG3584	3D domain protein
D9C18_RS15770	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D9C18_RS15775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9C18_RS15780	COG2056	Na+-H+ antiporter family
D9C18_RS15785	COG1268	BioY protein
D9C18_RS15790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9C18_RS15795	COG2819	hydrolase of the alpha beta superfamily
D9C18_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS15805	COG1169	isochorismate synthase
D9C18_RS15810	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9C18_RS15815	COG1535	isochorismatase
D9C18_RS15815	COG3433	isochorismatase activity
D9C18_RS15820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS15825	COG3251	PFAM MbtH domain protein
D9C18_RS15830	COG5634	Uncharacterized conserved protein (DUF2278)
D9C18_RS15835	COG0686	Belongs to the AlaDH PNT family
D9C18_RS15840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D9C18_RS15840	COG2508	Transcriptional regulator
D9C18_RS15850	COG4842	Belongs to the WXG100 family
D9C18_RS15855	COG5417	Belongs to the EsaB family
D9C18_RS15860	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9C18_RS15865	COG1674	ftsk spoiiie
D9C18_RS15865	COG0433	COG0433 Predicted ATPase
D9C18_RS15870	COG1511	domain protein
D9C18_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS15885	COG1418	mRNA catabolic process
D9C18_RS15900	COG0628	permease
D9C18_RS15915	COG5506	Protein of unknown function (DUF1694)
D9C18_RS15920	COG1335	isochorismatase
D9C18_RS15925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D9C18_RS15930	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D9C18_RS15950	COG0142	geranyltranstransferase activity
D9C18_RS15960	COG4585	Histidine kinase
D9C18_RS15965	COG2197	response regulator
D9C18_RS15970	COG2050	protein possibly involved in aromatic compounds catabolism
D9C18_RS15975	COG1320	monovalent cation:proton antiporter activity
D9C18_RS15980	COG2212	antiporter activity
D9C18_RS15985	COG1863	multisubunit Na H antiporter MnhE subunit
D9C18_RS15990	COG0651	ATP synthesis coupled electron transport
D9C18_RS15995	COG1006	Multisubunit Na H antiporter MnhC subunit
D9C18_RS16000	COG2111	Na H antiporter
D9C18_RS16005	COG2111	Na H antiporter
D9C18_RS16005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9C18_RS16015	COG3493	citrate carrier protein
D9C18_RS16020	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9C18_RS16025	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9C18_RS16030	COG3845	ABC transporter
D9C18_RS16035	COG1744	ABC transporter substrate-binding protein PnrA-like
D9C18_RS16040	COG4565	transcriptional regulatory protein
D9C18_RS16045	COG3290	protein histidine kinase activity
D9C18_RS16055	COG3011	Protein conserved in bacteria
D9C18_RS16060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C18_RS16065	COG2814	Major facilitator Superfamily
D9C18_RS16075	COG5018	Exonuclease
D9C18_RS16085	COG2205	protein histidine kinase activity
D9C18_RS16090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D9C18_RS16100	COG2267	carboxylic ester hydrolase activity
D9C18_RS16105	COG1522	sequence-specific DNA binding
D9C18_RS16110	COG0436	Aminotransferase
D9C18_RS16115	COG1098	S1 RNA binding domain
D9C18_RS16120	COG2155	Conserved Protein
D9C18_RS16125	COG1979	alcohol dehydrogenase
D9C18_RS16130	COG1979	alcohol dehydrogenase
D9C18_RS16135	COG0166	Belongs to the GPI family
D9C18_RS16150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9C18_RS16165	COG2738	Putative neutral zinc metallopeptidase
D9C18_RS16170	COG1253	flavin adenine dinucleotide binding
D9C18_RS16175	COG0366	Alpha amylase catalytic
D9C18_RS16185	COG0432	Pfam Uncharacterised protein family UPF0047
D9C18_RS16200	COG0840	transmembrane signaling receptor activity
D9C18_RS16210	COG0840	transmembrane signaling receptor activity
D9C18_RS16225	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS16225	COG3347	Dehydrogenase
D9C18_RS16230	COG1349	DNA-binding transcription factor activity
D9C18_RS16235	COG1070	Carbohydrate kinase
D9C18_RS16240	COG3254	rhamnose metabolic process
D9C18_RS16245	COG4806	L-rhamnose isomerase
D9C18_RS16250	COG0673	inositol 2-dehydrogenase activity
D9C18_RS16255	COG0628	permease
D9C18_RS16260	COG1968	undecaprenyl-diphosphatase activity
D9C18_RS16270	COG5553	Cysteine dioxygenase type I
D9C18_RS16275	COG0477	Major facilitator Superfamily
D9C18_RS16280	COG1705	Flagellar rod assembly protein muramidase FlgJ
D9C18_RS16285	COG4682	membrane
D9C18_RS16290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9C18_RS16295	COG0569	domain protein
D9C18_RS16305	COG1510	regulation of RNA biosynthetic process
D9C18_RS16310	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS16315	COG1454	alcohol dehydrogenase
D9C18_RS16325	COG2318	DinB family
D9C18_RS16330	COG1585	Membrane protein implicated in regulation of membrane protease activity
D9C18_RS16335	COG2268	Band 7 protein
D9C18_RS16340	COG1247	-acetyltransferase
D9C18_RS16345	COG3859	Proton-coupled thiamine transporter YuaJ
D9C18_RS16470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9C18_RS16475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9C18_RS16480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9C18_RS16485	COG0297	glycogen (starch) synthase activity
D9C18_RS16490	COG0058	SHG alpha-glucan phosphorylase activity
D9C18_RS16495	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D9C18_RS16500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C18_RS16505	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS16510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C18_RS16520	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS16525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C18_RS16530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9C18_RS16535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C18_RS16540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C18_RS16545	COG1169	isochorismate synthase
D9C18_RS16550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D9C18_RS16555	COG0596	Alpha beta hydrolase
D9C18_RS16560	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9C18_RS16565	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS16570	COG4948	Mandelate Racemase Muconate Lactonizing
D9C18_RS16575	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9C18_RS16580	COG1121	(ABC) transporter
D9C18_RS16585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C18_RS16585	COG1321	iron dependent repressor
D9C18_RS16590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9C18_RS16600	COG1294	oxidase, subunit
D9C18_RS16605	COG1271	oxidase subunit
D9C18_RS16610	COG0254	rRNA binding
D9C18_RS16615	COG0288	reversible hydration of carbon dioxide
D9C18_RS16620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9C18_RS16625	COG1854	S-ribosylhomocysteine lyase activity
D9C18_RS16640	COG0783	Belongs to the Dps family
D9C18_RS16645	COG4824	toxin secretion phage lysis holin
D9C18_RS16650	COG0494	nUDIX hydrolase
D9C18_RS16655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9C18_RS16660	COG1116	anion transmembrane transporter activity
D9C18_RS16665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9C18_RS16670	COG1506	peptidase
D9C18_RS16680	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D9C18_RS16685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9C18_RS16690	COG0367	asparagine synthase
D9C18_RS16695	COG1113	amino acid transport
D9C18_RS16700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9C18_RS16705	COG2267	carboxylic ester hydrolase activity
D9C18_RS16715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D9C18_RS16720	COG1242	4 iron, 4 sulfur cluster binding
D9C18_RS16735	COG1725	Transcriptional regulator
D9C18_RS16740	COG1131	(ABC) transporter
D9C18_RS16755	COG1136	(ABC) transporter
D9C18_RS16760	COG0577	efflux transmembrane transporter activity
D9C18_RS16765	COG0745	RESPONSE REGULATOR receiver
D9C18_RS16770	COG2205	protein histidine kinase activity
D9C18_RS16775	COG1136	(ABC) transporter
D9C18_RS16780	COG0577	efflux transmembrane transporter activity
D9C18_RS16785	COG2433	Pfam Transposase IS66
D9C18_RS16790	COG2814	Major facilitator Superfamily
D9C18_RS16795	COG2202	Pas domain
D9C18_RS16795	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS16805	COG0495	leucyl-tRNA aminoacylation
D9C18_RS16810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9C18_RS16815	COG1486	melibiose metabolic process
D9C18_RS16820	COG0395	ABC-type sugar transport system, permease component
D9C18_RS16825	COG1175	transmembrane transport
D9C18_RS16830	COG1653	transport
D9C18_RS16835	COG1609	Transcriptional regulator
D9C18_RS16840	COG1073	alpha beta
D9C18_RS16850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C18_RS16870	COG2124	cytochrome p450
D9C18_RS16875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9C18_RS16880	COG0395	ABC-type sugar transport system, permease component
D9C18_RS16885	COG1653	transport
D9C18_RS16895	COG4209	transmembrane transport
D9C18_RS16900	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D9C18_RS16905	COG1653	transport
D9C18_RS16925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9C18_RS16930	COG2081	HI0933 family
D9C18_RS16935	COG2244	polysaccharide biosynthetic process
D9C18_RS16940	COG1187	pseudouridine synthase activity
D9C18_RS16945	COG1349	DNA-binding transcription factor activity
D9C18_RS16950	COG1131	(ABC) transporter
D9C18_RS16955	COG4473	ABC transporter
D9C18_RS16960	COG2252	PERMEase
D9C18_RS16965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C18_RS16970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C18_RS16975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9C18_RS16985	COG1597	lipid kinase activity
D9C18_RS16990	COG1523	belongs to the glycosyl hydrolase 13 family
D9C18_RS16995	COG0510	thiamine kinase activity
D9C18_RS17005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9C18_RS17010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS17015	COG0281	malic enzyme
D9C18_RS17020	COG5584	Small secreted protein
D9C18_RS17025	COG1363	Peptidase, m42
D9C18_RS17040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS17045	COG4848	Belongs to the UPF0354 family
D9C18_RS17050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C18_RS17055	COG1674	ftsk spoiiie
D9C18_RS17060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9C18_RS17065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D9C18_RS17070	COG4980	gas vesicle protein
D9C18_RS17075	COG3118	belongs to the thioredoxin family
D9C18_RS17080	COG1605	Chorismate mutase
D9C18_RS17080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D9C18_RS17085	COG1609	Transcriptional regulator
D9C18_RS17090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9C18_RS17095	COG1360	Flagellar Motor Protein
D9C18_RS17100	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9C18_RS17105	COG0517	IMP dehydrogenase activity
D9C18_RS17110	COG0454	-acetyltransferase
D9C18_RS17115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9C18_RS17120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9C18_RS17125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9C18_RS17135	COG2203	Gaf domain
D9C18_RS17135	COG2199	diguanylate cyclase activity
D9C18_RS17140	COG1956	GAF domain-containing protein
D9C18_RS17145	COG1309	transcriptional regulator
D9C18_RS17150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9C18_RS17155	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D9C18_RS17160	COG1114	Component of the transport system for branched-chain amino acids
D9C18_RS17165	COG1104	cysteine desulfurase activity
D9C18_RS17170	COG0301	tRNA thio-modification
D9C18_RS17180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9C18_RS17185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D9C18_RS17190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9C18_RS17195	COG0616	signal peptide processing
D9C18_RS17200	COG1714	RDD family
D9C18_RS17210	COG3874	Sporulation protein YtfJ
D9C18_RS17215	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D9C18_RS17220	COG0827	DNA restriction-modification system
D9C18_RS17230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9C18_RS17235	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9C18_RS17240	COG0137	argininosuccinate synthase activity
D9C18_RS17245	COG0165	Argininosuccinate lyase
D9C18_RS17255	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS17260	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D9C18_RS17270	COG4109	DRTGG domain
D9C18_RS17280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D9C18_RS17300	COG0587	DNA-directed DNA polymerase activity
D9C18_RS17305	COG0281	malic enzyme
D9C18_RS17310	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9C18_RS17315	COG0825	malonyl-CoA metabolic process
D9C18_RS17320	COG0205	6-phosphofructokinase activity
D9C18_RS17325	COG0469	pyruvate kinase activity
D9C18_RS17330	COG3030	protein affecting phage T7 exclusion by the F plasmid
D9C18_RS17335	COG0628	permease
D9C18_RS17340	COG2707	UPF0756 membrane protein
D9C18_RS17345	COG0372	Belongs to the citrate synthase family
D9C18_RS17350	COG0538	isocitrate dehydrogenase activity
D9C18_RS17355	COG0039	L-malate dehydrogenase activity
D9C18_RS17360	COG0745	RESPONSE REGULATOR receiver
D9C18_RS17365	COG5002	protein histidine kinase activity
D9C18_RS17370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C18_RS17370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C18_RS17375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9C18_RS17380	COG1971	Probably functions as a manganese efflux pump
D9C18_RS17385	COG0237	dephospho-CoA kinase activity
D9C18_RS17390	COG0656	L-ascorbic acid biosynthetic process
D9C18_RS17395	COG2814	Major facilitator Superfamily
D9C18_RS17400	COG1733	regulation of RNA biosynthetic process
D9C18_RS17405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9C18_RS17410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9C18_RS17415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9C18_RS17420	COG3611	Membrane attachment protein
D9C18_RS17425	COG1484	DNA-dependent DNA replication
D9C18_RS17430	COG0398	Pfam SNARE associated Golgi protein
D9C18_RS17440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9C18_RS17445	COG1011	Hydrolase
D9C18_RS17450	COG3275	phosphorelay sensor kinase activity
D9C18_RS17455	COG3279	Response regulator of the LytR AlgR family
D9C18_RS17460	COG1380	Effector of murein hydrolase LrgA
D9C18_RS17465	COG1346	cytolysis
D9C18_RS17475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9C18_RS17480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9C18_RS17485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9C18_RS17490	COG3326	Membrane
D9C18_RS17500	COG1363	Peptidase, m42
D9C18_RS17510	COG2160	L-arabinose isomerase activity
D9C18_RS17515	COG1069	ribulokinase activity
D9C18_RS17520	COG0235	Class ii aldolase
D9C18_RS17525	COG0647	UMP catabolic process
D9C18_RS17530	COG0371	Dehydrogenase
D9C18_RS17535	COG1653	transport
D9C18_RS17540	COG1175	transmembrane transport
D9C18_RS17545	COG0395	ABC-type sugar transport system, permease component
D9C18_RS17550	COG3534	alpha-L-arabinofuranosidase
D9C18_RS17555	COG1966	Carbon starvation protein
D9C18_RS17560	COG0346	lactoylglutathione lyase activity
D9C18_RS17565	COG0247	lactate metabolic process
D9C18_RS17570	COG0277	FAD linked oxidase domain protein
D9C18_RS17575	COG3835	regulator
D9C18_RS17585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9C18_RS17595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9C18_RS17600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C18_RS17600	COG0072	phenylalanine-tRNA ligase activity
D9C18_RS17605	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9C18_RS17610	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D9C18_RS17615	COG1286	toxin biosynthetic process
D9C18_RS17620	COG1796	DNA polymerase
D9C18_RS17620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D9C18_RS17625	COG1193	negative regulation of DNA recombination
D9C18_RS17630	COG3766	membrane
D9C18_RS17635	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS17640	COG1309	transcriptional regulator
D9C18_RS17645	COG1024	Enoyl-CoA hydratase
D9C18_RS17650	COG2086	electron transfer activity
D9C18_RS17655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9C18_RS17660	COG3534	alpha-L-arabinofuranosidase
D9C18_RS17665	COG3118	belongs to the thioredoxin family
D9C18_RS17670	COG0322	excinuclease ABC activity
D9C18_RS17680	COG0527	aspartate kinase activity
D9C18_RS17685	COG1719	4-vinyl reductase, 4VR
D9C18_RS17690	COG2009	succinate dehydrogenase
D9C18_RS17695	COG1053	succinate dehydrogenase
D9C18_RS17700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D9C18_RS17705	COG0824	Thioesterase
D9C18_RS17710	COG2197	response regulator
D9C18_RS17715	COG1846	Transcriptional regulator
D9C18_RS17720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9C18_RS17725	COG5401	PFAM Sporulation and spore germination
D9C18_RS17730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9C18_RS17735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9C18_RS17740	COG0622	Phosphoesterase
D9C18_RS17765	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
D9C18_RS17795	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D9C18_RS17810	COG0028	Belongs to the TPP enzyme family
D9C18_RS17815	COG0440	acetolactate synthase activity
D9C18_RS17820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9C18_RS17825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9C18_RS17830	COG0473	3-isopropylmalate dehydrogenase activity
D9C18_RS17835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9C18_RS17840	COG0066	3-isopropylmalate dehydratase activity
D9C18_RS17845	COG1477	protein flavinylation
D9C18_RS17845	COG0457	Tetratricopeptide repeat
D9C18_RS17850	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9C18_RS17855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9C18_RS17860	COG1067	ATP-dependent peptidase activity
D9C18_RS17860	COG0470	DNA polymerase III
D9C18_RS17865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9C18_RS17870	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9C18_RS17880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9C18_RS17885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9C18_RS17890	COG0181	hydroxymethylbilane synthase activity
D9C18_RS17895	COG1587	Uroporphyrinogen-III synthase
D9C18_RS17900	COG0113	porphobilinogen synthase activity
D9C18_RS17905	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9C18_RS17910	COG1388	LysM domain
D9C18_RS17915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9C18_RS17925	COG0525	valine-tRNA ligase activity
D9C18_RS17930	COG0285	dihydrofolate synthase activity
D9C18_RS17935	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D9C18_RS17945	COG0424	maF-like protein
D9C18_RS17950	COG2003	Belongs to the UPF0758 family
D9C18_RS17955	COG1077	Cell shape determining protein MreB Mrl
D9C18_RS17965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D9C18_RS17970	COG0850	regulation of cytokinetic process
D9C18_RS17975	COG2894	cell division
D9C18_RS17980	COG0739	heme binding
D9C18_RS17985	COG1994	Peptidase M50
D9C18_RS17990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9C18_RS17995	COG2868	ribosomal protein
D9C18_RS18000	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D9C18_RS18010	COG3290	protein histidine kinase activity
D9C18_RS18015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9C18_RS18020	COG4492	Belongs to the UPF0735 family
D9C18_RS18025	COG0077	Prephenate dehydratase
D9C18_RS18030	COG1827	regulation of RNA biosynthetic process
D9C18_RS18035	COG1104	cysteine desulfurase activity
D9C18_RS18040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9C18_RS18045	COG0157	Belongs to the NadC ModD family
D9C18_RS18050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D9C18_RS18055	COG1388	LysM domain
D9C18_RS18065	COG0217	transcriptional regulatory protein
D9C18_RS18070	COG1115	amino acid carrier protein
D9C18_RS18090	COG2112	serine threonine protein kinase
D9C18_RS18095	COG0673	inositol 2-dehydrogenase activity
D9C18_RS18100	COG2814	Major facilitator Superfamily
D9C18_RS18110	COG0632	four-way junction helicase activity
D9C18_RS18115	COG2255	four-way junction helicase activity
D9C18_RS18125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9C18_RS18130	COG0343	queuine tRNA-ribosyltransferase activity
D9C18_RS18135	COG1862	Preprotein translocase
D9C18_RS18145	COG2323	membrane
D9C18_RS18150	COG2244	polysaccharide biosynthetic process
D9C18_RS18160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9C18_RS18160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D9C18_RS18165	COG0490	domain, Protein
D9C18_RS18170	COG5416	Lipopolysaccharide assembly protein A domain
D9C18_RS18175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D9C18_RS18175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D9C18_RS18180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C18_RS18185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9C18_RS18190	COG1490	D-aminoacyl-tRNA deacylase activity
D9C18_RS18195	COG4991	sh3 domain protein
D9C18_RS18195	COG3103	Sh3 type 3 domain protein
D9C18_RS18195	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS18205	COG0124	histidyl-tRNA synthetase
D9C18_RS18210	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9C18_RS18220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9C18_RS18225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9C18_RS18230	COG1959	2 iron, 2 sulfur cluster binding
D9C18_RS18235	COG1104	cysteine desulfurase activity
D9C18_RS18240	COG0482	sulfurtransferase activity
D9C18_RS18245	COG0457	Tetratricopeptide repeat
D9C18_RS18250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9C18_RS18255	COG3881	PFAM PRC-barrel domain
D9C18_RS18270	COG0765	amino acid transport
D9C18_RS18275	COG0765	amino acid transport
D9C18_RS18280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C18_RS18285	COG1126	abc transporter atp-binding protein
D9C18_RS18290	COG0628	permease
D9C18_RS18295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9C18_RS18300	COG4472	Bacterial protein of unknown function (DUF965)
D9C18_RS18305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9C18_RS18310	COG3906	Belongs to the UPF0473 family
D9C18_RS18315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9C18_RS18320	COG4122	O-methyltransferase activity
D9C18_RS18325	COG0826	peptidase U32
D9C18_RS18330	COG0826	peptidase U32
D9C18_RS18335	COG0572	uridine kinase
D9C18_RS18340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9C18_RS18345	COG0768	penicillin binding
D9C18_RS18360	COG2226	methyltransferase
D9C18_RS18365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9C18_RS18370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9C18_RS18375	COG0626	cystathionine gamma-synthase activity
D9C18_RS18390	COG2427	Protein of unknown function (DUF1641)
D9C18_RS18395	COG3383	formate dehydrogenase (NAD+) activity
D9C18_RS18400	COG5609	conserved protein (DUF2294)
D9C18_RS18405	COG2116	formate transmembrane transporter activity
D9C18_RS18420	COG2226	methyltransferase
D9C18_RS18425	COG1309	transcriptional regulator
D9C18_RS18450	COG1595	DNA-templated transcription, initiation
D9C18_RS18455	COG1378	Sugar-specific transcriptional regulator TrmB
D9C18_RS18460	COG1280	lysine exporter protein (LysE YggA)
D9C18_RS18465	COG1113	amino acid transport
D9C18_RS18475	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9C18_RS18475	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D9C18_RS18480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9C18_RS18485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9C18_RS18490	COG3715	PTS system
D9C18_RS18495	COG3716	PTS system mannose fructose sorbose family IID component
D9C18_RS18500	COG1621	beta-fructofuranosidase activity
D9C18_RS18505	COG0693	protein deglycase activity
D9C18_RS18510	COG1064	alcohol dehydrogenase
D9C18_RS18520	COG0789	Transcriptional regulator
D9C18_RS18525	COG5577	PFAM Coat F domain
D9C18_RS18535	COG1063	alcohol dehydrogenase
D9C18_RS18540	COG5577	PFAM Coat F domain
D9C18_RS18550	COG0346	lactoylglutathione lyase activity
D9C18_RS18560	COG4991	sh3 domain protein
D9C18_RS18565	COG4991	sh3 domain protein
D9C18_RS18575	COG5566	PFAM Mor transcription activator
D9C18_RS18580	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS18585	COG0667	Aldo Keto reductase
D9C18_RS18590	COG1595	DNA-templated transcription, initiation
D9C18_RS18595	COG3443	Belongs to the bacterial solute-binding protein 9 family
D9C18_RS18615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9C18_RS18630	COG2070	2-Nitropropane dioxygenase
D9C18_RS18640	COG2318	DinB family
D9C18_RS18655	COG1335	isochorismatase
D9C18_RS18665	COG2124	cytochrome p450
D9C18_RS18670	COG2732	(Barnase) inhibitor
D9C18_RS18675	COG1522	sequence-specific DNA binding
D9C18_RS18685	COG1687	branched-chain amino acid
D9C18_RS18690	COG1114	Component of the transport system for branched-chain amino acids
D9C18_RS18700	COG1230	cation diffusion facilitator family transporter
D9C18_RS18705	COG2072	flavoprotein involved in K transport
D9C18_RS18710	COG0583	DNA-binding transcription factor activity
D9C18_RS18715	COG0697	spore germination
D9C18_RS18725	COG1253	flavin adenine dinucleotide binding
D9C18_RS18730	COG0456	acetyltransferase
D9C18_RS18735	COG2814	Major facilitator Superfamily
D9C18_RS18740	COG0789	Transcriptional regulator
D9C18_RS18740	COG4978	Transcriptional regulator
D9C18_RS18865	COG0457	Tetratricopeptide repeat
D9C18_RS18880	COG0583	DNA-binding transcription factor activity
D9C18_RS18885	COG0114	fumarate hydratase activity
D9C18_RS18905	COG3209	COG3209 Rhs family protein
D9C18_RS18915	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D9C18_RS18920	COG0398	Pfam SNARE associated Golgi protein
D9C18_RS18925	COG5632	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS18925	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS18930	COG2755	lipolytic protein G-D-S-L family
D9C18_RS18940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D9C18_RS18945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D9C18_RS18950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9C18_RS18955	COG1534	Rna-binding protein
D9C18_RS18960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9C18_RS18965	COG1713	HD superfamily hydrolase involved in NAD metabolism
D9C18_RS18970	COG0799	negative regulation of ribosome biogenesis
D9C18_RS18975	COG2226	methyltransferase
D9C18_RS18980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C18_RS18985	COG1596	polysaccharide export
D9C18_RS18985	COG1555	photosystem II stabilization
D9C18_RS18990	COG2131	deaminase
D9C18_RS18995	COG0658	competence protein
D9C18_RS18995	COG2333	competence protein COMEC
D9C18_RS19010	COG1466	dna polymerase III delta subunit
D9C18_RS19015	COG0268	Binds directly to 16S ribosomal RNA
D9C18_RS19020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D9C18_RS19025	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS19035	COG0481	GTPase activity
D9C18_RS19040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9C18_RS19045	COG1420	regulation of RNA biosynthetic process
D9C18_RS19050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9C18_RS19055	COG0443	Heat shock 70 kDa protein
D9C18_RS19060	COG0484	heat shock protein binding
D9C18_RS19065	COG2264	protein methyltransferase activity
D9C18_RS19070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9C18_RS19075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9C18_RS19080	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9C18_RS19090	COG1610	YqeY-like protein
D9C18_RS19095	COG1030	water channel activity
D9C18_RS19100	COG4864	UPF0365 protein
D9C18_RS19115	COG0561	phosphatase activity
D9C18_RS19120	COG1702	phosphate starvation-inducible protein PhoH
D9C18_RS19125	COG1480	7TM receptor with intracellular HD hydrolase
D9C18_RS19130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9C18_RS19135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D9C18_RS19140	COG0295	cytidine deaminase activity
D9C18_RS19145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9C18_RS19155	COG1381	Involved in DNA repair and RecF pathway recombination
D9C18_RS19160	COG0752	glycyl-tRNA synthetase alpha subunit
D9C18_RS19165	COG0751	glycine-tRNA ligase activity
D9C18_RS19170	COG0517	IMP dehydrogenase activity
D9C18_RS19175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9C18_RS19180	COG1671	Belongs to the UPF0178 family
D9C18_RS19185	COG0358	DNA primase activity
D9C18_RS19190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9C18_RS19200	COG2010	Cytochrome c
D9C18_RS19205	COG2384	SAM-dependent methyltransferase
D9C18_RS19210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9C18_RS19215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9C18_RS19225	COG0513	Belongs to the DEAD box helicase family
D9C18_RS19230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D9C18_RS19240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS19245	COG0735	belongs to the Fur family
D9C18_RS19250	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D9C18_RS19255	COG4709	membrane
D9C18_RS19260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9C18_RS19265	COG1388	LysM domain
D9C18_RS19270	COG5521	maltodextrose utilization protein MalA
D9C18_RS19275	COG2839	Protein conserved in bacteria
D9C18_RS19280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9C18_RS19285	COG0477	Major facilitator Superfamily
D9C18_RS19290	COG0768	penicillin binding
D9C18_RS19295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9C18_RS19300	COG0573	inorganic phosphate transmembrane transporter activity
D9C18_RS19305	COG0581	inorganic phosphate transmembrane transporter activity
D9C18_RS19310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C18_RS19315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9C18_RS19320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9C18_RS19335	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS19345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9C18_RS19355	COG0705	Rhomboid family
D9C18_RS19355	COG0457	Tetratricopeptide repeat
D9C18_RS19360	COG4483	Protein conserved in bacteria
D9C18_RS19365	COG1940	carbohydrate kinase activity
D9C18_RS19370	COG1368	sulfuric ester hydrolase activity
D9C18_RS19375	COG2866	Carboxypeptidase
D9C18_RS19385	COG0011	TIGRFAM Protein of
D9C18_RS19395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS19405	COG1393	Belongs to the ArsC family
D9C18_RS19415	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS19420	COG1253	flavin adenine dinucleotide binding
D9C18_RS19425	COG0598	Magnesium transport protein CorA
D9C18_RS19430	COG0517	IMP dehydrogenase activity
D9C18_RS19435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9C18_RS19440	COG1459	type II secretion system
D9C18_RS19445	COG4537	Required for transformation and DNA binding
D9C18_RS19450	COG4970	Tfp pilus assembly protein FimT
D9C18_RS19460	COG4940	Competence protein ComGF
D9C18_RS19485	COG0681	Belongs to the peptidase S26 family
D9C18_RS19495	COG1396	sequence-specific DNA binding
D9C18_RS19510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9C18_RS19515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9C18_RS19520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9C18_RS19525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9C18_RS19530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9C18_RS19535	COG0095	Lipoate-protein ligase
D9C18_RS19540	COG1321	iron dependent repressor
D9C18_RS19545	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9C18_RS19555	COG3872	metal-dependent enzyme
D9C18_RS19565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9C18_RS19570	COG0006	proline dipeptidase activity
D9C18_RS19575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9C18_RS19585	COG3854	ATPases associated with a variety of cellular activities
D9C18_RS19630	COG0511	ligase activity, forming carbon-carbon bonds
D9C18_RS19635	COG0439	Biotin carboxylase
D9C18_RS19640	COG1302	Protein conserved in bacteria
D9C18_RS19645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9C18_RS19650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9C18_RS19655	COG1570	exodeoxyribonuclease VII activity
D9C18_RS19660	COG1722	exodeoxyribonuclease VII activity
D9C18_RS19665	COG0142	geranyltranstransferase activity
D9C18_RS19670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9C18_RS19675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D9C18_RS19680	COG1438	arginine binding
D9C18_RS19685	COG0497	DNA recombination
D9C18_RS19690	COG0750	zinc metalloprotease
D9C18_RS19700	COG0745	RESPONSE REGULATOR receiver
D9C18_RS19705	COG1902	pentaerythritol trinitrate reductase activity
D9C18_RS19720	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9C18_RS19725	COG0584	glycerophosphoryl diester phosphodiesterase
D9C18_RS19730	COG0183	Belongs to the thiolase family
D9C18_RS19735	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9C18_RS19740	COG1960	acyl-CoA dehydrogenase activity
D9C18_RS19745	COG0372	Belongs to the citrate synthase family
D9C18_RS19750	COG2079	MmgE PrpD family protein
D9C18_RS19755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9C18_RS19765	COG3829	transcription factor binding
D9C18_RS19765	COG3290	protein histidine kinase activity
D9C18_RS19770	COG0280	phosphate acetyltransferase
D9C18_RS19775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C18_RS19780	COG3426	butyrate kinase activity
D9C18_RS19785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9C18_RS19790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9C18_RS19795	COG0022	dehydrogenase e1 component
D9C18_RS19800	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C18_RS19805	COG0789	Transcriptional regulator
D9C18_RS19805	COG4978	Transcriptional regulator
D9C18_RS19815	COG1597	lipid kinase activity
D9C18_RS19825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9C18_RS19830	COG0765	amino acid transport
D9C18_RS19835	COG1126	abc transporter atp-binding protein
D9C18_RS19840	COG4129	membrane
D9C18_RS19845	COG1376	ErfK ybiS ycfS ynhG family protein
D9C18_RS19850	COG0346	lactoylglutathione lyase activity
D9C18_RS19860	COG2195	Cleaves the N-terminal amino acid of tripeptides
D9C18_RS19870	COG0706	membrane insertase activity
D9C18_RS19880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9C18_RS19885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9C18_RS19890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9C18_RS19895	COG1234	tRNA 3'-trailer cleavage
D9C18_RS19905	COG0596	Alpha beta hydrolase
D9C18_RS19920	COG1902	pentaerythritol trinitrate reductase activity
D9C18_RS19925	COG4187	Peptidase family M20/M25/M40
D9C18_RS19930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D9C18_RS19935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS19940	COG0300	oxidoreductase activity
D9C18_RS19945	COG3048	D-serine ammonia-lyase activity
D9C18_RS19950	COG1072	(Pantothenic acid kinase))
D9C18_RS19955	COG0346	lactoylglutathione lyase activity
D9C18_RS19960	COG2211	Major facilitator Superfamily
D9C18_RS19970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9C18_RS19980	COG0456	acetyltransferase
D9C18_RS19985	COG2329	Antibiotic biosynthesis monooxygenase
D9C18_RS19990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D9C18_RS19990	COG0456	acetyltransferase
D9C18_RS19995	COG4918	Iron-sulphur cluster biosynthesis
D9C18_RS20005	COG1073	alpha beta
D9C18_RS20015	COG0667	Aldo Keto reductase
D9C18_RS20025	COG0494	nUDIX hydrolase
D9C18_RS20030	COG1379	DNA repair
D9C18_RS20035	COG1396	sequence-specific DNA binding
D9C18_RS20040	COG0252	asparaginase activity
D9C18_RS20045	COG1027	Aspartate ammonia-lyase
D9C18_RS20050	COG1757	Na H antiporter
D9C18_RS20055	COG0281	malic enzyme
D9C18_RS20065	COG1300	Membrane
D9C18_RS20070	COG0735	belongs to the Fur family
D9C18_RS20080	COG4974	Belongs to the 'phage' integrase family
D9C18_RS20085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D9C18_RS20090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9C18_RS20095	COG1686	Belongs to the peptidase S11 family
D9C18_RS20100	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS20105	COG2172	sigma factor antagonist activity
D9C18_RS20110	COG1191	sigma factor activity
D9C18_RS20145	COG0697	spore germination
D9C18_RS20150	COG0019	diaminopimelate decarboxylase activity
D9C18_RS20155	COG4086	secreted protein
D9C18_RS20170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9C18_RS20225	COG3328	transposase activity
D9C18_RS20275	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D9C18_RS20285	COG0681	Belongs to the peptidase S26 family
D9C18_RS20295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9C18_RS20295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9C18_RS20300	COG0307	riboflavin synthase, alpha
D9C18_RS20305	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9C18_RS20305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9C18_RS20310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9C18_RS20315	COG0456	acetyltransferase
D9C18_RS20320	COG1547	Domain of unknown function (DUF309)
D9C18_RS20325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D9C18_RS20330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9C18_RS20340	COG1686	Belongs to the peptidase S11 family
D9C18_RS20345	COG2715	membrane protein required for spore maturation
D9C18_RS20350	COG0700	Nucleoside recognition
D9C18_RS20355	COG1187	pseudouridine synthase activity
D9C18_RS20360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS20365	COG1333	cytochrome c biogenesis protein
D9C18_RS20370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9C18_RS20375	COG0745	RESPONSE REGULATOR receiver
D9C18_RS20380	COG5002	protein histidine kinase activity
D9C18_RS20385	COG1595	DNA-templated transcription, initiation
D9C18_RS20395	COG0710	3-dehydroquinate dehydratase activity
D9C18_RS20400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9C18_RS20405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D9C18_RS20410	COG1141	Ferredoxin
D9C18_RS20415	COG4955	Helix-turn-helix domain
D9C18_RS20420	COG0514	ATP-dependent DNA helicase (RecQ)
D9C18_RS20425	COG1266	CAAX protease self-immunity
D9C18_RS20430	COG1388	LysM domain
D9C18_RS20440	COG1408	metallophosphoesterase
D9C18_RS20445	COG4862	establishment of competence for transformation
D9C18_RS20450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9C18_RS20455	COG0492	ferredoxin-NADP+ reductase activity
D9C18_RS20460	COG2339	peptidase activity
D9C18_RS20465	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS20465	COG3773	Cell wall hydrolase
D9C18_RS20470	COG2959	enzyme of heme biosynthesis
D9C18_RS20475	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D9C18_RS20485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9C18_RS20490	COG0539	negative regulation of cytoplasmic translation
D9C18_RS20495	COG1304	FMN binding
D9C18_RS20520	COG1160	GTP binding
D9C18_RS20525	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9C18_RS20540	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9C18_RS20545	COG0776	regulation of translation
D9C18_RS20550	COG0302	gtp cyclohydrolase
D9C18_RS20560	COG0142	geranyltranstransferase activity
D9C18_RS20565	COG2226	methyltransferase
D9C18_RS20570	COG0142	geranyltranstransferase activity
D9C18_RS20575	COG0105	UTP biosynthetic process
D9C18_RS20580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9C18_RS20585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9C18_RS20590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9C18_RS20595	COG4401	Chorismate mutase type I
D9C18_RS20600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9C18_RS20605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9C18_RS20615	COG0135	phosphoribosylanthranilate isomerase activity
D9C18_RS20620	COG0133	tryptophan synthase activity
D9C18_RS20635	COG0287	Prephenate dehydrogenase
D9C18_RS20640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9C18_RS20645	COG0457	Tetratricopeptide repeat
D9C18_RS20650	COG5582	Belongs to the UPF0302 family
D9C18_RS20660	COG0723	plastoquinol--plastocyanin reductase activity
D9C18_RS20665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9C18_RS20670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9C18_RS20670	COG2010	Cytochrome c
D9C18_RS20675	COG4347	Protein of unknown function (DUF1405)
D9C18_RS20685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D9C18_RS20690	COG1694	Mazg nucleotide pyrophosphohydrolase
D9C18_RS20695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9C18_RS20700	COG1803	Methylglyoxal synthase
D9C18_RS20705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C18_RS20710	COG0438	transferase activity, transferring glycosyl groups
D9C18_RS20715	COG0617	tRNA 3'-terminal CCA addition
D9C18_RS20720	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D9C18_RS20720	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D9C18_RS20725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9C18_RS20730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9C18_RS20735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9C18_RS20740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9C18_RS20740	COG1199	ATP-dependent helicase activity
D9C18_RS20750	COG5353	protein conserved in bacteria
D9C18_RS20755	COG0436	Aminotransferase
D9C18_RS20760	COG0017	Asparaginyl-tRNA synthetase
D9C18_RS20765	COG3935	DnaD domain protein
D9C18_RS20770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9C18_RS20780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9C18_RS20780	COG4499	WXG100 protein secretion system (Wss), protein YukC
D9C18_RS20785	COG3331	DNA recombination
D9C18_RS20820	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C18_RS20825	COG2190	(PTS) system
D9C18_RS20830	COG1205	dead DEAH box helicase
D9C18_RS20830	COG1111	helicase
D9C18_RS20835	COG3359	exonuclease
D9C18_RS20850	COG4474	Belongs to the UPF0398 family
D9C18_RS20865	COG0116	Belongs to the methyltransferase superfamily
D9C18_RS20880	COG1199	ATP-dependent helicase activity
D9C18_RS20885	COG1028	Short-chain dehydrogenase reductase Sdr
D9C18_RS20890	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D9C18_RS20895	COG1609	Transcriptional regulator
D9C18_RS20900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9C18_RS20905	COG0800	Aldolase
D9C18_RS20915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D9C18_RS20920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9C18_RS20925	COG2233	PERMEase
D9C18_RS20930	COG3424	synthase
D9C18_RS20935	COG1755	Isoprenylcysteine carboxyl methyltransferase
D9C18_RS20945	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D9C18_RS20960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9C18_RS20970	COG0328	RNA-DNA hybrid ribonuclease activity
D9C18_RS20975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D9C18_RS20980	COG0328	RNA-DNA hybrid ribonuclease activity
D9C18_RS21000	COG1278	Cold shock
D9C18_RS21010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9C18_RS21015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9C18_RS21020	COG0386	Belongs to the glutathione peroxidase family
D9C18_RS21025	COG1418	mRNA catabolic process
D9C18_RS21030	COG1413	lyase activity
D9C18_RS21035	COG0129	dihydroxy-acid dehydratase activity
D9C18_RS21045	COG2521	methyltransferase
D9C18_RS21045	COG2136	Putative SAM-dependent methyltransferase
D9C18_RS21055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D9C18_RS21060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9C18_RS21065	COG0204	Acyl-transferase
D9C18_RS21070	COG1272	protein, Hemolysin III
D9C18_RS21075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9C18_RS21080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9C18_RS21090	COG1999	signal sequence binding
D9C18_RS21095	COG2755	lipolytic protein G-D-S-L family
D9C18_RS21100	COG4698	Protein conserved in bacteria
D9C18_RS21115	COG1846	Transcriptional regulator
D9C18_RS21120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9C18_RS21125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9C18_RS21130	COG1086	Polysaccharide biosynthesis protein
D9C18_RS21135	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D9C18_RS21140	COG4641	Protein conserved in bacteria
D9C18_RS21155	COG0463	Glycosyl transferase, family 2
D9C18_RS21160	COG0456	acetyltransferase
D9C18_RS21175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9C18_RS21180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9C18_RS21185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9C18_RS21190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9C18_RS21195	COG0456	acetyltransferase
D9C18_RS21200	COG1509	lysine 2,3-aminomutase activity
D9C18_RS21210	COG4479	Belongs to the UPF0346 family
D9C18_RS21235	COG0671	phosphoesterase, PA-phosphatase related
D9C18_RS21250	COG0813	purine-nucleoside phosphorylase activity
D9C18_RS21255	COG1876	peptidase activity
D9C18_RS21265	COG2226	methyltransferase
D9C18_RS21270	COG3409	Peptidoglycan-binding domain 1 protein
D9C18_RS21270	COG0793	Belongs to the peptidase S41A family
D9C18_RS21275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9C18_RS21290	COG0400	carboxylic ester hydrolase activity
D9C18_RS21300	COG0778	Nitroreductase
D9C18_RS21305	COG1733	regulation of RNA biosynthetic process
D9C18_RS21310	COG1942	4-Oxalocrotonate Tautomerase
D9C18_RS21330	COG2962	Rard protein
D9C18_RS21340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C18_RS21345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9C18_RS21350	COG1366	Belongs to the anti-sigma-factor antagonist family
D9C18_RS21355	COG0534	Mate efflux family protein
D9C18_RS21360	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D9C18_RS21365	COG1819	glycosyl
D9C18_RS21370	COG1388	LysM domain
D9C18_RS21370	COG0791	NLP P60 protein
D9C18_RS21375	COG2032	superoxide dismutase activity
D9C18_RS21380	COG0714	Associated with various cellular activities
D9C18_RS21385	COG4548	von Willebrand factor, type A
D9C18_RS21390	COG0567	Dehydrogenase, E1 component
D9C18_RS21395	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9C18_RS21400	COG0385	Bile acid
D9C18_RS21405	COG0733	neurotransmitter:sodium symporter activity
D9C18_RS21410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D9C18_RS21415	COG1657	PFAM Prenyltransferase squalene oxidase
D9C18_RS21420	COG1012	belongs to the aldehyde dehydrogenase family
D9C18_RS21445	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C18_RS21460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9C18_RS21465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9C18_RS21480	COG0514	ATP-dependent DNA helicase (RecQ)
D9C18_RS21485	COG3584	3D domain protein
D9C18_RS21485	COG1388	LysM domain
D9C18_RS21490	COG2197	response regulator
D9C18_RS21495	COG4585	Histidine kinase
D9C18_RS21500	COG3239	Fatty acid desaturase
D9C18_RS21505	COG1619	proteins homologs of microcin C7 resistance protein MccF
D9C18_RS21520	COG2322	membrane
D9C18_RS21525	COG0741	lytic transglycosylase activity
D9C18_RS21530	COG0640	Transcriptional regulator
D9C18_RS21540	COG2378	regulation of single-species biofilm formation
D9C18_RS21545	COG3708	Transcriptional regulator
D9C18_RS21550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9C18_RS21555	COG1309	transcriptional regulator
D9C18_RS21560	COG0456	acetyltransferase
D9C18_RS21565	COG0662	Cupin 2, conserved barrel domain protein
D9C18_RS21565	COG2207	Transcriptional regulator
D9C18_RS21570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9C18_RS21575	COG1231	oxidoreductase activity
D9C18_RS21580	COG4282	regulation of fungal-type cell wall biogenesis
D9C18_RS21585	COG5444	nuclease activity
D9C18_RS21605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS21635	COG3328	transposase activity
D9C18_RS21640	COG2211	Major facilitator Superfamily
D9C18_RS21645	COG2226	methyltransferase
D9C18_RS21650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9C18_RS21710	COG3328	transposase activity
D9C18_RS21750	COG3328	transposase activity
D9C18_RS21760	COG2814	Major facilitator Superfamily
D9C18_RS21770	COG1131	(ABC) transporter
D9C18_RS21785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9C18_RS21795	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D9C18_RS21800	COG0300	oxidoreductase activity
D9C18_RS21830	COG0583	DNA-binding transcription factor activity
D9C18_RS21835	COG0067	glutamate synthase
D9C18_RS21835	COG0069	glutamate synthase activity
D9C18_RS21835	COG0070	glutamate synthase
D9C18_RS21840	COG0493	'glutamate synthase
D9C18_RS21845	COG0604	alcohol dehydrogenase
D9C18_RS21850	COG0583	DNA-binding transcription factor activity
D9C18_RS21855	COG0405	Gamma-glutamyltransferase
D9C18_RS21860	COG0166	Belongs to the GPI family
D9C18_RS21865	COG0582	viral genome integration into host DNA
D9C18_RS21885	COG0534	Mate efflux family protein
D9C18_RS21890	COG2017	converts alpha-aldose to the beta-anomer
D9C18_RS21895	COG2027	D-alanyl-D-alanine carboxypeptidase
D9C18_RS21900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9C18_RS21915	COG1649	PFAM Uncharacterised BCR, COG1649
D9C18_RS21925	COG1960	acyl-CoA dehydrogenase activity
D9C18_RS21930	COG0318	PFAM AMP-dependent synthetase and ligase
D9C18_RS21935	COG0439	Biotin carboxylase
D9C18_RS21940	COG0511	ligase activity, forming carbon-carbon bonds
D9C18_RS21945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9C18_RS21950	COG1024	Enoyl-CoA hydratase
D9C18_RS21955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9C18_RS21960	COG2404	hydrolase activity, acting on ester bonds
D9C18_RS21965	COG0586	Pfam SNARE associated Golgi protein
D9C18_RS21970	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D9C18_RS21975	COG2246	polysaccharide biosynthetic process
D9C18_RS21985	COG5520	Belongs to the glycosyl hydrolase 30 family
D9C18_RS21995	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9C18_RS22000	COG1115	amino acid carrier protein
D9C18_RS22010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9C18_RS22015	COG0187	DNA topoisomerase II activity
D9C18_RS22020	COG1832	CoA-binding protein
D9C18_RS22025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9C18_RS22030	COG4841	protein insertion into membrane
D9C18_RS22040	COG0824	Thioesterase
D9C18_RS22060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9C18_RS22065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9C18_RS22080	COG0071	Belongs to the small heat shock protein (HSP20) family
D9C18_RS22090	COG4846	Membrane protein involved in cytochrome C biogenesis
D9C18_RS22095	COG2201	protein-glutamate methylesterase activity
D9C18_RS22100	COG0785	Cytochrome C biogenesis protein
D9C18_RS22110	COG3763	UPF0154 protein
D9C18_RS22120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9C18_RS22125	COG4224	UPF0291 protein
D9C18_RS22130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9C18_RS22135	COG1388	LysM domain
D9C18_RS22140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9C18_RS22150	COG0346	lactoylglutathione lyase activity
D9C18_RS22160	COG4195	phage-related replication protein
D9C18_RS22220	COG0629	single-stranded DNA binding
D9C18_RS22235	COG0582	viral genome integration into host DNA
D9C18_RS22265	COG1793	dna ligase
D9C18_RS22280	COG1525	nuclease
D9C18_RS22390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9C18_RS22440	COG0457	Tetratricopeptide repeat
D9C18_RS22575	COG3883	PFAM NLP P60 protein
D9C18_RS22575	COG0791	NLP P60 protein