locus-tag	class	description
H8S71_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H8S71_RS00010	COG0592	DNA-directed DNA polymerase activity
H8S71_RS00015	COG2501	S4 domain
H8S71_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H8S71_RS00030	COG0187	DNA topoisomerase II activity
H8S71_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8S71_RS00070	COG0516	GMP reductase activity
H8S71_RS00070	COG0517	IMP dehydrogenase activity
H8S71_RS00075	COG1686	Belongs to the peptidase S11 family
H8S71_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H8S71_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H8S71_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H8S71_RS00100	COG1428	Deoxynucleoside kinase
H8S71_RS00105	COG1428	Deoxynucleoside kinase
H8S71_RS00110	COG3858	chitin binding
H8S71_RS00110	COG1388	LysM domain
H8S71_RS00115	COG1335	isochorismatase
H8S71_RS00120	COG0590	tRNA wobble adenosine to inosine editing
H8S71_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H8S71_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H8S71_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H8S71_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
H8S71_RS00190	COG3853	Toxic anion resistance protein (TelA)
H8S71_RS00195	COG1982	Orn Lys Arg decarboxylase major
H8S71_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H8S71_RS00205	COG3870	Protein conserved in bacteria
H8S71_RS00210	COG1728	Protein conserved in bacteria
H8S71_RS00215	COG0470	DNA polymerase III
H8S71_RS00220	COG1774	PSP1 C-terminal conserved region
H8S71_RS00225	COG4467	Involved in initiation control of chromosome replication
H8S71_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H8S71_RS00235	COG2827	Endonuclease containing a URI domain
H8S71_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H8S71_RS00245	COG2002	toxin-antitoxin pair type II binding
H8S71_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_RS00255	COG0084	hydrolase, TatD family'
H8S71_RS00260	COG3583	domain protein
H8S71_RS00260	COG3584	3D domain protein
H8S71_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H8S71_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H8S71_RS00280	COG4466	Protein conserved in bacteria
H8S71_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H8S71_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_RS00300	COG0251	oxidation-reduction process
H8S71_RS00305	COG2088	sporulation resulting in formation of a cellular spore
H8S71_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H8S71_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H8S71_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H8S71_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
H8S71_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H8S71_RS00340	COG2002	toxin-antitoxin pair type II binding
H8S71_RS00345	COG2244	polysaccharide biosynthetic process
H8S71_RS00350	COG3956	TIGRFAM MazG family protein
H8S71_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H8S71_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H8S71_RS00375	COG1098	S1 RNA binding domain
H8S71_RS00390	COG2208	phosphoserine phosphatase activity
H8S71_RS00395	COG2304	oxidoreductase activity
H8S71_RS00400	COG0515	serine threonine protein kinase
H8S71_RS00405	COG0037	tRNA processing
H8S71_RS00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H8S71_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H8S71_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H8S71_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H8S71_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8S71_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8S71_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
H8S71_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H8S71_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H8S71_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H8S71_RS00470	COG1396	sequence-specific DNA binding
H8S71_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8S71_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H8S71_RS00560	COG4463	regulation of RNA biosynthetic process
H8S71_RS00565	COG3880	PFAM UvrB UvrC protein
H8S71_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H8S71_RS00575	COG0542	response to heat
H8S71_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H8S71_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
H8S71_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
H8S71_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H8S71_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H8S71_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H8S71_RS00610	COG1045	serine acetyltransferase
H8S71_RS00615	COG0215	cysteine-tRNA ligase activity
H8S71_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H8S71_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8S71_RS00630	COG3688	RNA-binding protein containing a PIN domain
H8S71_RS00635	COG1595	DNA-templated transcription, initiation
H8S71_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8S71_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
H8S71_RS00660	COG0081	regulation of translation
H8S71_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H8S71_RS00675	COG2813	Specifically methylates the guanine in position
H8S71_RS00680	COG0085	RNA polymerase activity
H8S71_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H8S71_RS00690	COG1358	cellular component organization or biogenesis
H8S71_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H8S71_RS00700	COG0049	tRNA binding
H8S71_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H8S71_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H8S71_RS00715	COG0596	Alpha beta hydrolase
H8S71_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H8S71_RS00730	COG0088	Forms part of the polypeptide exit tunnel
H8S71_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H8S71_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H8S71_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H8S71_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H8S71_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H8S71_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H8S71_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H8S71_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H8S71_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H8S71_RS00820	COG0200	Binds to the 23S rRNA
H8S71_RS00825	COG0201	protein transport
H8S71_RS00830	COG0563	adenylate kinase activity
H8S71_RS00835	COG0024	Methionine aminopeptidase
H8S71_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H8S71_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H8S71_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H8S71_RS00865	COG0202	RNA polymerase activity
H8S71_RS00870	COG0203	ribosomal protein L17
H8S71_RS00875	COG1122	ATPase activity
H8S71_RS00880	COG1122	ATPase activity
H8S71_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8S71_RS00890	COG0101	tRNA pseudouridine synthase activity
H8S71_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H8S71_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H8S71_RS00905	COG2226	methyltransferase
H8S71_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS00920	COG0489	protein tyrosine kinase activity
H8S71_RS00930	COG2194	sulfuric ester hydrolase activity
H8S71_RS00935	COG0726	polysaccharide deacetylase
H8S71_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
H8S71_RS01025	COG0385	Bile acid
H8S71_RS01030	COG2819	hydrolase of the alpha beta superfamily
H8S71_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS01050	COG2207	Transcriptional regulator
H8S71_RS01055	COG3876	Protein conserved in bacteria
H8S71_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
H8S71_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_RS01070	COG1263	PTS System
H8S71_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS01075	COG1737	Transcriptional regulator
H8S71_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H8S71_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS01090	COG1683	Conserved Protein
H8S71_RS01120	COG1595	DNA-templated transcription, initiation
H8S71_RS01125	COG5662	AntiSigma factor
H8S71_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8S71_RS01135	COG4856	YbbR-like protein
H8S71_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8S71_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H8S71_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8S71_RS01160	COG2169	Transcriptional regulator
H8S71_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8S71_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8S71_RS01175	COG3002	Belongs to the UPF0753 family
H8S71_RS01180	COG0288	reversible hydration of carbon dioxide
H8S71_RS01190	COG5609	conserved protein (DUF2294)
H8S71_RS01195	COG0640	Transcriptional regulator
H8S71_RS01200	COG2814	Major facilitator Superfamily
H8S71_RS01215	COG1404	Belongs to the peptidase S8 family
H8S71_RS01235	COG1132	(ABC) transporter
H8S71_RS01240	COG0596	Alpha beta hydrolase
H8S71_RS01245	COG0745	RESPONSE REGULATOR receiver
H8S71_RS01250	COG0642	Histidine kinase
H8S71_RS01260	COG0515	serine threonine protein kinase
H8S71_RS01275	COG1113	amino acid transport
H8S71_RS01290	COG2602	Beta-lactamase
H8S71_RS01295	COG2124	cytochrome p450
H8S71_RS01305	COG0531	amino acid
H8S71_RS01315	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_RS01320	COG2271	Major facilitator Superfamily
H8S71_RS01330	COG0456	acetyltransferase
H8S71_RS01330	COG1846	Transcriptional regulator
H8S71_RS01335	COG2271	Major facilitator Superfamily
H8S71_RS01340	COG0697	spore germination
H8S71_RS01345	COG2207	Transcriptional regulator
H8S71_RS01345	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS01350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H8S71_RS01355	COG3591	Belongs to the peptidase S1B family
H8S71_RS01365	COG0596	Alpha beta hydrolase
H8S71_RS01370	COG1183	phosphatidylcholine synthase activity
H8S71_RS01375	COG0586	Pfam SNARE associated Golgi protein
H8S71_RS01380	COG0688	phosphatidylethanolamine metabolic process
H8S71_RS01390	COG2312	Erythromycin esterase
H8S71_RS01395	COG1054	Belongs to the UPF0176 family
H8S71_RS01400	COG1301	dicarboxylic acid transport
H8S71_RS01405	COG2190	(PTS) system
H8S71_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS01405	COG1263	PTS System
H8S71_RS01410	COG0363	glucosamine-6-phosphate deaminase activity
H8S71_RS01415	COG2188	Transcriptional regulator
H8S71_RS01425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_RS01430	COG0833	amino acid
H8S71_RS01435	COG2040	homocysteine
H8S71_RS01440	COG1115	amino acid carrier protein
H8S71_RS01445	COG2066	Belongs to the glutaminase family
H8S71_RS01450	COG4191	Histidine kinase
H8S71_RS01455	COG0784	Response regulator, receiver
H8S71_RS01460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8S71_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS01470	COG2271	Major facilitator Superfamily
H8S71_RS01475	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_RS01480	COG2186	Transcriptional regulator
H8S71_RS01485	COG2721	sulfolactate sulfo-lyase activity
H8S71_RS01490	COG3173	Aminoglycoside phosphotransferase
H8S71_RS01500	COG0697	spore germination
H8S71_RS01505	COG0745	RESPONSE REGULATOR receiver
H8S71_RS01510	COG2205	protein histidine kinase activity
H8S71_RS01515	COG1131	(ABC) transporter
H8S71_RS01535	COG3773	Cell wall hydrolase
H8S71_RS01540	COG2304	oxidoreductase activity
H8S71_RS01550	COG3540	Alkaline phosphatase
H8S71_RS01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_RS01560	COG0805	protein transport
H8S71_RS01565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H8S71_RS01570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8S71_RS01575	COG0477	Major facilitator Superfamily
H8S71_RS01580	COG1309	transcriptional regulator
H8S71_RS01585	COG0252	asparaginase activity
H8S71_RS01590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H8S71_RS01595	COG1714	RDD family
H8S71_RS01600	COG3012	SEC-C Motif Domain Protein
H8S71_RS01600	COG1405	negative regulation of cell septum assembly
H8S71_RS01605	COG3290	protein histidine kinase activity
H8S71_RS01610	COG3279	Response regulator of the LytR AlgR family
H8S71_RS01615	COG4555	ABC transporter
H8S71_RS01620	COG1668	transmembrane transport
H8S71_RS01625	COG0667	Aldo Keto reductase
H8S71_RS01640	COG1595	DNA-templated transcription, initiation
H8S71_RS01645	COG1595	DNA-templated transcription, initiation
H8S71_RS01650	COG1876	peptidase activity
H8S71_RS01655	COG0457	Tetratricopeptide repeat
H8S71_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS01665	COG0366	Alpha amylase catalytic
H8S71_RS01670	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8S71_RS01675	COG1121	(ABC) transporter
H8S71_RS01680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_RS01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS01690	COG2310	stress, protein
H8S71_RS01695	COG2310	stress, protein
H8S71_RS01700	COG2310	stress, protein
H8S71_RS01705	COG0861	Integral membrane protein TerC family
H8S71_RS01715	COG3853	Toxic anion resistance protein (TelA)
H8S71_RS01720	COG0477	Major facilitator Superfamily
H8S71_RS01725	COG2814	Major facilitator Superfamily
H8S71_RS01730	COG0640	Transcriptional regulator
H8S71_RS01735	COG0517	IMP dehydrogenase activity
H8S71_RS01735	COG4175	Glycine betaine
H8S71_RS01740	COG4176	ABC-type proline glycine betaine transport system permease component
H8S71_RS01745	COG2113	Glycine betaine
H8S71_RS01750	COG1473	amidohydrolase
H8S71_RS01755	COG1288	antiporter activity
H8S71_RS01765	COG0366	Alpha amylase catalytic
H8S71_RS01770	COG0039	L-malate dehydrogenase activity
H8S71_RS01775	COG1620	l-lactate permease
H8S71_RS01780	COG2814	Major facilitator Superfamily
H8S71_RS01785	COG1846	Transcriptional regulator
H8S71_RS01790	COG1280	lysine exporter protein (LysE YggA)
H8S71_RS01795	COG3403	YqcI/YcgG family
H8S71_RS01800	COG1113	amino acid transport
H8S71_RS01805	COG3665	Urea carboxylase-associated protein
H8S71_RS01810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H8S71_RS01815	COG1660	Displays ATPase and GTPase activities
H8S71_RS01820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H8S71_RS01825	COG2226	methyltransferase
H8S71_RS01830	COG0583	DNA-binding transcription factor activity
H8S71_RS01835	COG3458	cephalosporin-C deacetylase activity
H8S71_RS01840	COG3541	Predicted nucleotidyltransferase
H8S71_RS01845	COG0506	proline dehydrogenase activity
H8S71_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS01855	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_RS01860	COG2508	Transcriptional regulator
H8S71_RS01865	COG3689	TIGRFAM TIGR03943 family protein
H8S71_RS01870	COG0701	Predicted permease
H8S71_RS01875	COG2267	carboxylic ester hydrolase activity
H8S71_RS01880	COG0492	ferredoxin-NADP+ reductase activity
H8S71_RS01885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8S71_RS01885	COG1587	Uroporphyrinogen-III synthase
H8S71_RS01890	COG2146	nitrite reductase [NAD(P)H] activity
H8S71_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_RS01900	COG0243	molybdopterin cofactor binding
H8S71_RS01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_RS01910	COG2223	nitrite transmembrane transporter activity
H8S71_RS01915	COG1469	GTP cyclohydrolase I activity
H8S71_RS01920	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_RS01930	COG0523	cobalamin synthesis protein
H8S71_RS01935	COG0765	amino acid transport
H8S71_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS01950	COG1714	RDD family
H8S71_RS01960	COG1846	Transcriptional regulator
H8S71_RS01970	COG3842	ATPase activity
H8S71_RS01975	COG2723	6-phospho-beta-galactosidase activity
H8S71_RS01985	COG3209	COG3209 Rhs family protein
H8S71_RS01990	COG0840	transmembrane signaling receptor activity
H8S71_RS01990	COG3290	protein histidine kinase activity
H8S71_RS01995	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H8S71_RS02000	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H8S71_RS02005	COG1733	regulation of RNA biosynthetic process
H8S71_RS02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS02025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H8S71_RS02030	COG2814	Major facilitator Superfamily
H8S71_RS02040	COG0697	spore germination
H8S71_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS02055	COG2364	Membrane
H8S71_RS02060	COG1126	abc transporter atp-binding protein
H8S71_RS02065	COG0765	amino acid transport
H8S71_RS02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS02075	COG0583	DNA-binding transcription factor activity
H8S71_RS02080	COG0163	prenyltransferase activity
H8S71_RS02085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H8S71_RS02100	COG0596	Alpha beta hydrolase
H8S71_RS02105	COG3104	oligopeptide transport
H8S71_RS02110	COG5434	Belongs to the glycosyl hydrolase 28 family
H8S71_RS02120	COG0697	spore germination
H8S71_RS02130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H8S71_RS02135	COG1136	(ABC) transporter
H8S71_RS02140	COG0577	efflux transmembrane transporter activity
H8S71_RS02145	COG0745	RESPONSE REGULATOR receiver
H8S71_RS02150	COG3850	Histidine kinase
H8S71_RS02150	COG5002	protein histidine kinase activity
H8S71_RS02155	COG0457	Tetratricopeptide repeat
H8S71_RS02175	COG0527	aspartate kinase activity
H8S71_RS02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS02185	COG4605	iron ion homeostasis
H8S71_RS02190	COG4604	ABC transporter, ATP-binding protein
H8S71_RS02195	COG4607	ABC-type enterochelin transport system periplasmic component
H8S71_RS02200	COG2814	Major facilitator Superfamily
H8S71_RS02205	COG1309	transcriptional regulator
H8S71_RS02210	COG0778	Nitroreductase
H8S71_RS02215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8S71_RS02220	COG0640	Transcriptional regulator
H8S71_RS02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H8S71_RS02235	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS02240	COG4975	Glucose uptake
H8S71_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS02250	COG4549	nuclear export factor GLE1
H8S71_RS02255	COG2372	response to copper ion
H8S71_RS02255	COG1276	copper resistance
H8S71_RS02260	COG1349	DNA-binding transcription factor activity
H8S71_RS02270	COG2213	PTS system mannitol-specific
H8S71_RS02275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS02280	COG0246	Mannitol dehydrogenase
H8S71_RS02285	COG0473	3-isopropylmalate dehydrogenase activity
H8S71_RS02290	COG0681	Belongs to the peptidase S26 family
H8S71_RS02295	COG0412	Dienelactone hydrolase
H8S71_RS02300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8S71_RS02310	COG0561	phosphatase activity
H8S71_RS02315	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H8S71_RS02320	COG1914	H( )-stimulated, divalent metal cation uptake system
H8S71_RS02325	COG4336	lyase activity
H8S71_RS02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H8S71_RS02335	COG1984	allophanate hydrolase subunit 2
H8S71_RS02340	COG1414	Transcriptional regulator
H8S71_RS02345	COG2755	lipolytic protein G-D-S-L family
H8S71_RS02355	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_RS02360	COG0768	penicillin binding
H8S71_RS02365	COG4989	oxidoreductase activity
H8S71_RS02370	COG3711	transcriptional antiterminator
H8S71_RS02375	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS02380	COG2226	methyltransferase
H8S71_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS02390	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS02395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS02400	COG3871	stress protein (general stress protein 26)
H8S71_RS02410	COG2814	Major facilitator Superfamily
H8S71_RS02415	COG1522	sequence-specific DNA binding
H8S71_RS02420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8S71_RS02420	COG0551	DNA topoisomerase type I activity
H8S71_RS02425	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H8S71_RS02430	COG3706	GGDEF domain
H8S71_RS02435	COG5298	Protein conserved in bacteria
H8S71_RS02440	COG1215	transferase activity, transferring glycosyl groups
H8S71_RS02450	COG0531	amino acid
H8S71_RS02455	COG0494	nUDIX hydrolase
H8S71_RS02460	COG0028	Belongs to the TPP enzyme family
H8S71_RS02470	COG1914	H( )-stimulated, divalent metal cation uptake system
H8S71_RS02475	COG2261	transglycosylase associated protein
H8S71_RS02480	COG4876	unkown
H8S71_RS02485	COG2217	Heavy metal translocating P-type atpase
H8S71_RS02490	COG3729	General stress protein
H8S71_RS02495	COG0662	Cupin 2, conserved barrel domain protein
H8S71_RS02505	COG3546	catalase activity
H8S71_RS02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H8S71_RS02515	COG3290	protein histidine kinase activity
H8S71_RS02520	COG4565	transcriptional regulatory protein
H8S71_RS02525	COG1301	dicarboxylic acid transport
H8S71_RS02530	COG0628	permease
H8S71_RS02535	COG1131	(ABC) transporter
H8S71_RS02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_RS02550	COG1960	acyl-CoA dehydrogenase activity
H8S71_RS02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_RS02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
H8S71_RS02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H8S71_RS02585	COG0513	Belongs to the DEAD box helicase family
H8S71_RS02590	COG3402	PFAM membrane-flanked domain
H8S71_RS02595	COG3428	Bacterial PH domain
H8S71_RS02600	COG0705	Rhomboid family
H8S71_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
H8S71_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H8S71_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8S71_RS02620	COG0864	Transcriptional regulator
H8S71_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
H8S71_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS02640	COG2172	sigma factor antagonist activity
H8S71_RS02645	COG2208	phosphoserine phosphatase activity
H8S71_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS02655	COG2172	sigma factor antagonist activity
H8S71_RS02660	COG1191	sigma factor activity
H8S71_RS02665	COG2208	phosphoserine phosphatase activity
H8S71_RS02675	COG1673	EVE domain
H8S71_RS02680	COG1846	Transcriptional regulator
H8S71_RS02685	COG2183	response to ionizing radiation
H8S71_RS02695	COG3091	SprT-like family
H8S71_RS02755	COG1476	TRANSCRIPTIONal
H8S71_RS02780	COG0693	protein deglycase activity
H8S71_RS02785	COG1278	Cold shock
H8S71_RS02790	COG1329	Transcriptional regulator
H8S71_RS02795	COG0697	spore germination
H8S71_RS02800	COG2207	Transcriptional regulator
H8S71_RS02800	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS02805	COG0697	spore germination
H8S71_RS02810	COG2207	Transcriptional regulator
H8S71_RS02810	COG3708	Transcriptional regulator
H8S71_RS02815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS02820	COG0477	Major facilitator Superfamily
H8S71_RS02830	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
H8S71_RS02840	COG0697	spore germination
H8S71_RS02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS02850	COG2030	dehydratase
H8S71_RS02855	COG3545	Serine hydrolase
H8S71_RS02860	COG1733	regulation of RNA biosynthetic process
H8S71_RS02865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS02870	COG0640	Transcriptional regulator
H8S71_RS02875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8S71_RS02885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS02890	COG1316	TRANSCRIPTIONal
H8S71_RS02905	COG5002	protein histidine kinase activity
H8S71_RS02910	COG0745	RESPONSE REGULATOR receiver
H8S71_RS02915	COG0697	spore germination
H8S71_RS02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8S71_RS02935	COG0640	Transcriptional regulator
H8S71_RS02940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8S71_RS02955	COG4585	Histidine kinase
H8S71_RS02960	COG2197	response regulator
H8S71_RS02965	COG2409	Drug exporters of the RND superfamily
H8S71_RS02970	COG1811	Na channel or pump
H8S71_RS02975	COG4978	Transcriptional regulator
H8S71_RS02975	COG0789	Transcriptional regulator
H8S71_RS02980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_RS02985	COG0778	Nitroreductase
H8S71_RS02990	COG0346	lactoylglutathione lyase activity
H8S71_RS02995	COG2259	Doxx family
H8S71_RS03000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS03030	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_RS03045	COG1309	transcriptional regulator
H8S71_RS03055	COG0456	acetyltransferase
H8S71_RS03060	COG0488	(ABC) transporter
H8S71_RS03065	COG1113	amino acid transport
H8S71_RS03070	COG2318	DinB family
H8S71_RS03075	COG1846	Transcriptional regulator
H8S71_RS03080	COG2409	Drug exporters of the RND superfamily
H8S71_RS03080	COG1033	growth of symbiont in host cell
H8S71_RS03085	COG0778	Nitroreductase
H8S71_RS03090	COG1846	Transcriptional regulator
H8S71_RS03095	COG2814	Major facilitator Superfamily
H8S71_RS03100	COG0730	response to heat
H8S71_RS03105	COG1802	Transcriptional regulator
H8S71_RS03110	COG1388	LysM domain
H8S71_RS03110	COG3858	chitin binding
H8S71_RS03115	COG1819	glycosyl
H8S71_RS03125	COG1785	Belongs to the alkaline phosphatase family
H8S71_RS03130	COG5646	InterPro IPR014922
H8S71_RS03140	COG0454	-acetyltransferase
H8S71_RS03145	COG1078	dGTPase activity
H8S71_RS03150	COG1388	LysM domain
H8S71_RS03155	COG2814	Major facilitator Superfamily
H8S71_RS03160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_RS03165	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8S71_RS03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_RS03175	COG2723	6-phospho-beta-galactosidase activity
H8S71_RS03180	COG2188	Transcriptional regulator
H8S71_RS03185	COG1940	carbohydrate kinase activity
H8S71_RS03190	COG1482	cell wall glycoprotein biosynthetic process
H8S71_RS03195	COG4124	Belongs to the glycosyl hydrolase 26 family
H8S71_RS03240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H8S71_RS03245	COG0802	atpase or kinase
H8S71_RS03250	COG1214	PFAM Peptidase M22, glycoprotease
H8S71_RS03255	COG0456	acetyltransferase
H8S71_RS03260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H8S71_RS03265	COG0488	(ABC) transporter
H8S71_RS03270	COG0315	cyclic pyranopterin monophosphate synthase activity
H8S71_RS03275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H8S71_RS03280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_RS03285	COG0805	protein transport
H8S71_RS03295	COG1266	CAAX protease self-immunity
H8S71_RS03305	COG0459	protein refolding
H8S71_RS03310	COG1073	alpha beta
H8S71_RS03315	COG0457	Tetratricopeptide repeat
H8S71_RS03320	COG1063	alcohol dehydrogenase
H8S71_RS03325	COG2211	Major facilitator Superfamily
H8S71_RS03330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_RS03335	COG1842	Phage shock protein A
H8S71_RS03340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8S71_RS03345	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H8S71_RS03350	COG4260	virion core protein, lumpy skin disease virus
H8S71_RS03360	COG2814	Major facilitator Superfamily
H8S71_RS03365	COG1063	alcohol dehydrogenase
H8S71_RS03370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H8S71_RS03375	COG0823	Involved in the tonB-independent uptake of proteins
H8S71_RS03390	COG2267	carboxylic ester hydrolase activity
H8S71_RS03400	COG2132	Multicopper oxidase
H8S71_RS03405	COG1113	amino acid transport
H8S71_RS03415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H8S71_RS03420	COG0714	Associated with various cellular activities
H8S71_RS03425	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H8S71_RS03430	COG1305	Transglutaminase-like
H8S71_RS03435	COG0519	Catalyzes the synthesis of GMP from XMP
H8S71_RS03435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H8S71_RS03450	COG2252	PERMEase
H8S71_RS03455	COG3064	Membrane
H8S71_RS03465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H8S71_RS03475	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H8S71_RS03480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H8S71_RS03485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H8S71_RS03490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H8S71_RS03495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8S71_RS03500	COG0047	phosphoribosylformylglycinamidine synthase activity
H8S71_RS03505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H8S71_RS03510	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H8S71_RS03515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H8S71_RS03520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H8S71_RS03525	COG0138	bifunctional purine biosynthesis protein purh
H8S71_RS03530	COG0151	Belongs to the GarS family
H8S71_RS03535	COG1522	sequence-specific DNA binding
H8S71_RS03540	COG0531	amino acid
H8S71_RS03550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H8S71_RS03555	COG1470	cell adhesion involved in biofilm formation
H8S71_RS03560	COG4496	protein, YerC YecD
H8S71_RS03565	COG0069	glutamate synthase activity
H8S71_RS03570	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H8S71_RS03575	COG0210	DNA helicase
H8S71_RS03580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H8S71_RS03585	COG4851	CamS sex pheromone cAM373 precursor
H8S71_RS03590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_RS03595	COG1285	pathogenesis
H8S71_RS03600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_RS03605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8S71_RS03610	COG0154	amidase activity
H8S71_RS03615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H8S71_RS03620	COG1309	transcriptional regulator
H8S71_RS03625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H8S71_RS03630	COG1597	lipid kinase activity
H8S71_RS03635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8S71_RS03655	COG5444	nuclease activity
H8S71_RS03660	COG3391	amine dehydrogenase activity
H8S71_RS03665	COG0457	Tetratricopeptide repeat
H8S71_RS03675	COG0217	transcriptional regulatory protein
H8S71_RS03685	COG1309	transcriptional regulator
H8S71_RS03690	COG3631	Ketosteroid isomerase-related protein
H8S71_RS03695	COG0702	epimerase
H8S71_RS03710	COG3546	catalase activity
H8S71_RS03715	COG0454	-acetyltransferase
H8S71_RS03725	COG5578	integral membrane protein
H8S71_RS03730	COG2972	Histidine kinase
H8S71_RS03735	COG4753	response regulator
H8S71_RS03735	COG2207	Transcriptional regulator
H8S71_RS03740	COG1653	transport
H8S71_RS03745	COG1175	transmembrane transport
H8S71_RS03750	COG0395	ABC-type sugar transport system, permease component
H8S71_RS03755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H8S71_RS03760	COG2207	Transcriptional regulator
H8S71_RS03765	COG2755	lipolytic protein G-D-S-L family
H8S71_RS03775	COG5578	integral membrane protein
H8S71_RS03780	COG3401	FG-GAP repeat protein
H8S71_RS03785	COG3401	FG-GAP repeat protein
H8S71_RS03790	COG2755	lipolytic protein G-D-S-L family
H8S71_RS03795	COG1874	Beta-galactosidase
H8S71_RS03805	COG1653	transport
H8S71_RS03810	COG4209	transmembrane transport
H8S71_RS03815	COG0395	ABC-type sugar transport system, permease component
H8S71_RS03820	COG1486	melibiose metabolic process
H8S71_RS03825	COG2323	membrane
H8S71_RS03830	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_RS03835	COG0346	lactoylglutathione lyase activity
H8S71_RS03850	COG5583	Uncharacterized small protein (DUF2292)
H8S71_RS03855	COG0670	Belongs to the BI1 family
H8S71_RS03860	COG0697	spore germination
H8S71_RS03865	COG1846	Transcriptional regulator
H8S71_RS03870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8S71_RS03885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_RS03885	COG2124	cytochrome p450
H8S71_RS03890	COG1368	sulfuric ester hydrolase activity
H8S71_RS03895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H8S71_RS03900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_RS03905	COG1442	glycosyl transferase family 8
H8S71_RS03910	COG1216	Glycosyl transferase, family 2
H8S71_RS03915	COG1442	glycosyl transferase family 8
H8S71_RS03920	COG2223	nitrite transmembrane transporter activity
H8S71_RS03925	COG1011	Hydrolase
H8S71_RS03930	COG0531	amino acid
H8S71_RS03935	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS03940	COG0840	transmembrane signaling receptor activity
H8S71_RS03945	COG0488	(ABC) transporter
H8S71_RS03955	COG0789	Transcriptional regulator
H8S71_RS03960	COG2814	Major facilitator Superfamily
H8S71_RS03970	COG0488	(ABC) transporter
H8S71_RS03975	COG0513	Belongs to the DEAD box helicase family
H8S71_RS03980	COG0456	acetyltransferase
H8S71_RS03985	COG2130	NADP-dependent
H8S71_RS03990	COG2211	Major facilitator Superfamily
H8S71_RS03995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H8S71_RS04000	COG1120	ATPase activity
H8S71_RS04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS04010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS04015	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H8S71_RS04030	COG3866	Pectate lyase
H8S71_RS04035	COG0471	metal ion transport
H8S71_RS04040	COG3290	protein histidine kinase activity
H8S71_RS04045	COG4565	transcriptional regulatory protein
H8S71_RS04050	COG3181	Tripartite tricarboxylate transporter family receptor
H8S71_RS04055	COG2851	Citrate transporter
H8S71_RS04060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS04065	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H8S71_RS04070	COG1254	Belongs to the acylphosphatase family
H8S71_RS04075	COG2258	MOSC domain
H8S71_RS04095	COG0024	Methionine aminopeptidase
H8S71_RS04100	COG1263	PTS System
H8S71_RS04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS04105	COG1368	sulfuric ester hydrolase activity
H8S71_RS04120	COG1115	amino acid carrier protein
H8S71_RS04125	COG0531	amino acid
H8S71_RS04140	COG0697	spore germination
H8S71_RS04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS04145	COG1263	PTS System
H8S71_RS04150	COG0366	Alpha amylase catalytic
H8S71_RS04155	COG2188	Transcriptional regulator
H8S71_RS04160	COG0778	Nitroreductase
H8S71_RS04165	COG0737	Belongs to the 5'-nucleotidase family
H8S71_RS04170	COG0693	protein deglycase activity
H8S71_RS04175	COG2814	Major facilitator Superfamily
H8S71_RS04180	COG4840	Belongs to the UPF0435 family
H8S71_RS04185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8S71_RS04190	COG4980	gas vesicle protein
H8S71_RS04195	COG1295	ribonuclease BN
H8S71_RS04200	COG0477	Major facilitator Superfamily
H8S71_RS04205	COG0387	Pfam Sodium calcium exchanger
H8S71_RS04215	COG0668	transmembrane transport
H8S71_RS04220	COG0535	radical SAM domain protein
H8S71_RS04230	COG0726	polysaccharide deacetylase
H8S71_RS04235	COG2084	Dehydrogenase
H8S71_RS04240	COG0598	Magnesium transport protein CorA
H8S71_RS04245	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H8S71_RS04250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H8S71_RS04260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H8S71_RS04265	COG4637	Psort location Cytoplasmic, score
H8S71_RS04275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_RS04280	COG0022	dehydrogenase e1 component
H8S71_RS04285	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_RS04290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_RS04295	COG3284	Transcriptional regulator
H8S71_RS04305	COG1742	UPF0060 membrane protein
H8S71_RS04330	COG4842	Belongs to the WXG100 family
H8S71_RS04345	COG5444	nuclease activity
H8S71_RS04360	COG1486	melibiose metabolic process
H8S71_RS04365	COG1737	Transcriptional regulator
H8S71_RS04370	COG1263	PTS System
H8S71_RS04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS04375	COG1132	(ABC) transporter
H8S71_RS04380	COG1132	(ABC) transporter
H8S71_RS04385	COG2259	Doxx family
H8S71_RS04390	COG2514	catechol 2,3-dioxygenase activity
H8S71_RS04395	COG4585	Histidine kinase
H8S71_RS04400	COG2197	response regulator
H8S71_RS04405	COG1131	(ABC) transporter
H8S71_RS04410	COG1511	domain protein
H8S71_RS04410	COG0842	Transport permease protein
H8S71_RS04415	COG0842	Transport permease protein
H8S71_RS04420	COG1695	Transcriptional regulator
H8S71_RS04425	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H8S71_RS04430	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
H8S71_RS04435	COG1309	transcriptional regulator
H8S71_RS04440	COG2814	Major facilitator Superfamily
H8S71_RS04445	COG2318	DinB family
H8S71_RS04450	COG2814	Major facilitator Superfamily
H8S71_RS04455	COG1846	Transcriptional regulator
H8S71_RS04460	COG0392	lysyltransferase activity
H8S71_RS04460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H8S71_RS04465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS04470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS04475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS04480	COG0384	phenazine biosynthesis protein PhzF
H8S71_RS04485	COG0778	Nitroreductase
H8S71_RS04500	COG1090	epimerase
H8S71_RS04505	COG2137	regulation of response to DNA damage stimulus
H8S71_RS04515	COG2814	Major facilitator Superfamily
H8S71_RS04530	COG3103	Sh3 type 3 domain protein
H8S71_RS04535	COG5658	integral membrane protein
H8S71_RS04540	COG0596	Alpha beta hydrolase
H8S71_RS04545	COG0463	Glycosyl transferase, family 2
H8S71_RS04550	COG4485	Bacterial membrane protein, YfhO
H8S71_RS04555	COG1988	membrane-bound metal-dependent
H8S71_RS04560	COG1194	a g-specific adenine glycosylase
H8S71_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS04585	COG3557	Belongs to the UPF0374 family
H8S71_RS04590	COG1132	(ABC) transporter
H8S71_RS04595	COG4129	membrane
H8S71_RS04600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8S71_RS04605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H8S71_RS04610	COG0735	belongs to the Fur family
H8S71_RS04720	COG4326	sporulation control protein
H8S71_RS04730	COG5577	PFAM Coat F domain
H8S71_RS04735	COG3340	Belongs to the peptidase S51 family
H8S71_RS04740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H8S71_RS04750	COG0753	catalase activity
H8S71_RS04755	COG1116	anion transmembrane transporter activity
H8S71_RS04760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8S71_RS04765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8S71_RS04770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS04780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H8S71_RS04790	COG1476	TRANSCRIPTIONal
H8S71_RS04800	COG3382	B3 4 domain protein
H8S71_RS04805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H8S71_RS04815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H8S71_RS04820	COG0789	Transcriptional regulator
H8S71_RS04825	COG1664	Polymer-forming cytoskeletal
H8S71_RS04830	COG1664	Polymer-forming cytoskeletal
H8S71_RS04835	COG2766	serine protein kinase
H8S71_RS04840	COG2718	Belongs to the UPF0229 family
H8S71_RS04845	COG1846	Transcriptional regulator
H8S71_RS04850	COG1566	PFAM secretion protein HlyD family protein
H8S71_RS04855	COG2814	Major facilitator Superfamily
H8S71_RS04860	COG0655	NAD(P)H dehydrogenase (quinone) activity
H8S71_RS04880	COG1725	Transcriptional regulator
H8S71_RS04885	COG1131	(ABC) transporter
H8S71_RS04890	COG1131	(ABC) transporter
H8S71_RS04895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_RS04900	COG1278	Cold shock
H8S71_RS04905	COG1464	Belongs to the NlpA lipoprotein family
H8S71_RS04910	COG3706	GGDEF domain
H8S71_RS04915	COG1823	symporter activity
H8S71_RS04935	COG5577	PFAM Coat F domain
H8S71_RS04940	COG1525	nuclease
H8S71_RS04940	COG4085	toxin activity
H8S71_RS04940	COG0737	Belongs to the 5'-nucleotidase family
H8S71_RS04945	COG3764	Sortase (surface protein transpeptidase)
H8S71_RS04950	COG0564	pseudouridine synthase activity
H8S71_RS04960	COG0517	IMP dehydrogenase activity
H8S71_RS04965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8S71_RS04970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8S71_RS04970	COG3153	acetyltransferase
H8S71_RS04975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_RS04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H8S71_RS04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H8S71_RS04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H8S71_RS04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H8S71_RS05000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H8S71_RS05005	COG4585	Histidine kinase
H8S71_RS05005	COG2203	Gaf domain
H8S71_RS05010	COG2197	response regulator
H8S71_RS05015	COG0431	NADPH-dependent FMN reductase
H8S71_RS05030	COG0791	NLP P60 protein
H8S71_RS05030	COG1388	LysM domain
H8S71_RS05035	COG1959	2 iron, 2 sulfur cluster binding
H8S71_RS05040	COG0668	transmembrane transport
H8S71_RS05045	COG2719	SpoVR family
H8S71_RS05050	COG1785	Belongs to the alkaline phosphatase family
H8S71_RS05055	COG0791	NLP P60 protein
H8S71_RS05055	COG1388	LysM domain
H8S71_RS05060	COG0583	DNA-binding transcription factor activity
H8S71_RS05065	COG0372	Belongs to the citrate synthase family
H8S71_RS05070	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS05075	COG0531	amino acid
H8S71_RS05080	COG0733	neurotransmitter:sodium symporter activity
H8S71_RS05085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS05090	COG0456	acetyltransferase
H8S71_RS05105	COG1595	DNA-templated transcription, initiation
H8S71_RS05110	COG0667	Aldo Keto reductase
H8S71_RS05115	COG0204	Acyl-transferase
H8S71_RS05120	COG1253	flavin adenine dinucleotide binding
H8S71_RS05125	COG0789	Transcriptional regulator
H8S71_RS05130	COG0436	Aminotransferase
H8S71_RS05135	COG1253	flavin adenine dinucleotide binding
H8S71_RS05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8S71_RS05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H8S71_RS05150	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_RS05160	COG0668	transmembrane transport
H8S71_RS05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H8S71_RS05170	COG0726	polysaccharide deacetylase
H8S71_RS05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_RS05180	COG1757	Na H antiporter
H8S71_RS05185	COG0589	response to stress
H8S71_RS05195	COG1132	(ABC) transporter
H8S71_RS05200	COG1132	(ABC) transporter
H8S71_RS05205	COG0702	epimerase
H8S71_RS05225	COG0189	ligase activity
H8S71_RS05230	COG0189	ligase activity
H8S71_RS05235	COG4399	Belongs to the UPF0754 family
H8S71_RS05240	COG3679	Belongs to the UPF0342 family
H8S71_RS05245	COG4335	DNA alkylation repair
H8S71_RS05250	COG0561	phosphatase activity
H8S71_RS05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8S71_RS05260	COG0475	glutathione-regulated potassium exporter activity
H8S71_RS05265	COG0490	domain, Protein
H8S71_RS05275	COG1024	Enoyl-CoA hydratase
H8S71_RS05285	COG4152	abc transporter atp-binding protein
H8S71_RS05290	COG1668	transmembrane transport
H8S71_RS05295	COG0420	3'-5' exonuclease activity
H8S71_RS05300	COG4717	serine-type aminopeptidase activity
H8S71_RS05305	COG3481	metal-dependent phosphohydrolase, HD sub domain
H8S71_RS05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H8S71_RS05345	COG1846	Transcriptional regulator
H8S71_RS05350	COG4980	gas vesicle protein
H8S71_RS05365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H8S71_RS05370	COG0537	adenosine 5'-monophosphoramidase activity
H8S71_RS05375	COG1131	(ABC) transporter
H8S71_RS05380	COG4473	ABC transporter
H8S71_RS05390	COG1473	amidohydrolase
H8S71_RS05395	COG3069	C4-dicarboxylate transmembrane transporter activity
H8S71_RS05405	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_RS05410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_RS05415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H8S71_RS05420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H8S71_RS05425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H8S71_RS05430	COG1309	transcriptional regulator
H8S71_RS05435	COG1511	domain protein
H8S71_RS05440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_RS05445	COG4377	Putative membrane peptidase family (DUF2324)
H8S71_RS05455	COG1363	Peptidase, m42
H8S71_RS05460	COG4405	Protein conserved in bacteria
H8S71_RS05465	COG1301	dicarboxylic acid transport
H8S71_RS05475	COG1234	tRNA 3'-trailer cleavage
H8S71_RS05480	COG0095	Lipoate-protein ligase
H8S71_RS05485	COG0702	epimerase
H8S71_RS05490	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS05500	COG0501	Belongs to the peptidase M48B family
H8S71_RS05510	COG0456	acetyltransferase
H8S71_RS05515	COG0604	alcohol dehydrogenase
H8S71_RS05520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H8S71_RS05525	COG0406	alpha-ribazole phosphatase activity
H8S71_RS05530	COG0183	Belongs to the thiolase family
H8S71_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS05540	COG1268	BioY protein
H8S71_RS05545	COG0840	transmembrane signaling receptor activity
H8S71_RS05550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_RS05550	COG0723	plastoquinol--plastocyanin reductase activity
H8S71_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS05565	COG4903	ComK protein
H8S71_RS05570	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS05580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_RS05595	COG0398	Pfam SNARE associated Golgi protein
H8S71_RS05600	COG0681	Belongs to the peptidase S26 family
H8S71_RS05605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H8S71_RS05610	COG1846	Transcriptional regulator
H8S71_RS05620	COG0738	Major facilitator superfamily
H8S71_RS05625	COG0673	inositol 2-dehydrogenase activity
H8S71_RS05630	COG0561	phosphatase activity
H8S71_RS05635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_RS05640	COG1609	Transcriptional regulator
H8S71_RS05645	COG3180	Ammonia monooxygenase
H8S71_RS05650	COG0477	Major facilitator Superfamily
H8S71_RS05650	COG2814	Major facilitator Superfamily
H8S71_RS05655	COG4533	DNA binding
H8S71_RS05665	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H8S71_RS05670	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H8S71_RS05675	COG1074	ATP-dependent DNA helicase activity
H8S71_RS05680	COG0420	3'-5' exonuclease activity
H8S71_RS05685	COG0419	ATPase involved in DNA repair
H8S71_RS05690	COG1403	HNH endonuclease
H8S71_RS05730	COG5337	Spore coat protein CotH
H8S71_RS05735	COG0179	Fumarylacetoacetate (FAA) hydrolase
H8S71_RS05745	COG1404	Belongs to the peptidase S8 family
H8S71_RS05755	COG0367	asparagine synthase
H8S71_RS05760	COG2318	DinB family
H8S71_RS05765	COG1562	ergosterol biosynthetic process
H8S71_RS05770	COG0534	Mate efflux family protein
H8S71_RS05775	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS05775	COG2207	Transcriptional regulator
H8S71_RS05780	COG1609	Transcriptional regulator
H8S71_RS05785	COG0673	inositol 2-dehydrogenase activity
H8S71_RS05790	COG2318	DinB family
H8S71_RS05795	COG1279	arginine transmembrane transporter activity
H8S71_RS05800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H8S71_RS05805	COG1357	PFAM Pentapeptide repeats (8 copies)
H8S71_RS05810	COG2267	carboxylic ester hydrolase activity
H8S71_RS05815	COG0529	Catalyzes the synthesis of activated sulfate
H8S71_RS05820	COG2046	Belongs to the sulfate adenylyltransferase family
H8S71_RS05825	COG0175	sulfate reduction
H8S71_RS05830	COG2045	Belongs to the ComB family
H8S71_RS05835	COG1809	phosphosulfolactate synthase activity
H8S71_RS05840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS05845	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_RS05850	COG2814	Major facilitator Superfamily
H8S71_RS05855	COG0454	-acetyltransferase
H8S71_RS05860	COG2153	protein acetylation
H8S71_RS05865	COG0646	methionine synthase
H8S71_RS05865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H8S71_RS05870	COG1666	GTP binding
H8S71_RS05875	COG2996	Protein conserved in bacteria
H8S71_RS05895	COG1695	Transcriptional regulator
H8S71_RS05910	COG3227	Zinc metalloprotease (Elastase)
H8S71_RS05915	COG1307	EDD domain protein, DegV family
H8S71_RS05920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS05940	COG0561	phosphatase activity
H8S71_RS05945	COG1073	alpha beta
H8S71_RS05950	COG2151	metal-sulfur cluster biosynthetic enzyme
H8S71_RS05960	COG0277	FAD linked oxidase domain protein
H8S71_RS05965	COG2271	Major facilitator Superfamily
H8S71_RS05970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H8S71_RS05975	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H8S71_RS05985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8S71_RS05990	COG0505	Belongs to the CarA family
H8S71_RS05995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8S71_RS06000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H8S71_RS06015	COG2267	carboxylic ester hydrolase activity
H8S71_RS06025	COG1744	ABC transporter substrate-binding protein PnrA-like
H8S71_RS06040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_RS06045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8S71_RS06050	COG5504	Zn-dependent protease
H8S71_RS06055	COG0444	Belongs to the ABC transporter superfamily
H8S71_RS06060	COG4608	Belongs to the ABC transporter superfamily
H8S71_RS06070	COG0601	transmembrane transport
H8S71_RS06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_RS06085	COG0180	Tryptophanyl-tRNA synthetase
H8S71_RS06090	COG4166	transmembrane transport
H8S71_RS06095	COG0601	transmembrane transport
H8S71_RS06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_RS06105	COG0444	Belongs to the ABC transporter superfamily
H8S71_RS06110	COG4608	Belongs to the ABC transporter superfamily
H8S71_RS06115	COG2814	Major facilitator Superfamily
H8S71_RS06120	COG0456	acetyltransferase
H8S71_RS06125	COG1393	Belongs to the ArsC family
H8S71_RS06130	COG0861	Integral membrane protein TerC family
H8S71_RS06140	COG4862	establishment of competence for transformation
H8S71_RS06150	COG4469	Competence protein
H8S71_RS06155	COG1164	Oligoendopeptidase f
H8S71_RS06165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8S71_RS06170	COG2346	COG2346, Truncated hemoglobins
H8S71_RS06175	COG0741	lytic transglycosylase activity
H8S71_RS06180	COG4116	CYTH
H8S71_RS06190	COG2357	RelA SpoT domain protein
H8S71_RS06195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8S71_RS06200	COG0564	pseudouridine synthase activity
H8S71_RS06205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H8S71_RS06210	COG0475	glutathione-regulated potassium exporter activity
H8S71_RS06210	COG0569	domain protein
H8S71_RS06215	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H8S71_RS06220	COG0352	thiamine-phosphate diphosphorylase activity
H8S71_RS06225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_RS06230	COG2104	thiamine diphosphate biosynthetic process
H8S71_RS06235	COG2022	thiamine diphosphate biosynthetic process
H8S71_RS06240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8S71_RS06245	COG0351	phosphomethylpyrimidine kinase
H8S71_RS06250	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H8S71_RS06305	COG0210	DNA helicase
H8S71_RS06315	COG2153	protein acetylation
H8S71_RS06320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H8S71_RS06325	COG2382	esterase
H8S71_RS06330	COG0626	cystathionine gamma-synthase activity
H8S71_RS06335	COG0626	cystathionine gamma-synthase activity
H8S71_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS06345	COG5505	Protein of unknown function (DUF819)
H8S71_RS06425	COG5444	nuclease activity
H8S71_RS06455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H8S71_RS06460	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS06470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS06470	COG3711	transcriptional antiterminator
H8S71_RS06475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_RS06475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_RS06475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS06480	COG1482	cell wall glycoprotein biosynthetic process
H8S71_RS06490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS06500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H8S71_RS06515	COG0109	protoheme IX farnesyltransferase activity
H8S71_RS06525	COG0726	polysaccharide deacetylase
H8S71_RS06540	COG5504	Zn-dependent protease
H8S71_RS06545	COG2205	protein histidine kinase activity
H8S71_RS06555	COG3383	formate dehydrogenase (NAD+) activity
H8S71_RS06560	COG2427	Protein of unknown function (DUF1641)
H8S71_RS06570	COG1051	belongs to the nudix hydrolase family
H8S71_RS06580	COG2124	cytochrome p450
H8S71_RS06585	COG1819	glycosyl
H8S71_RS06595	COG1587	Uroporphyrinogen-III synthase
H8S71_RS06600	COG0390	transport system, permease component
H8S71_RS06605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_RS06610	COG0697	spore germination
H8S71_RS06615	COG4297	protein containing double-stranded beta helix domain
H8S71_RS06625	COG1252	NADH dehydrogenase
H8S71_RS06630	COG1904	glucuronate isomerase
H8S71_RS06635	COG2211	Major facilitator Superfamily
H8S71_RS06640	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H8S71_RS06645	COG1063	alcohol dehydrogenase
H8S71_RS06650	COG1312	Catalyzes the dehydration of D-mannonate
H8S71_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS06660	COG2271	Major facilitator Superfamily
H8S71_RS06665	COG1609	Transcriptional regulator
H8S71_RS06670	COG0246	Mannitol dehydrogenase
H8S71_RS06675	COG2721	sulfolactate sulfo-lyase activity
H8S71_RS06680	COG0730	response to heat
H8S71_RS06685	COG2318	DinB family
H8S71_RS06695	COG0457	Tetratricopeptide repeat
H8S71_RS06705	COG2350	Protein conserved in bacteria
H8S71_RS06710	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS06710	COG1388	LysM domain
H8S71_RS06710	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS06720	COG4195	phage-related replication protein
H8S71_RS06725	COG3546	catalase activity
H8S71_RS06730	COG2856	Zn peptidase
H8S71_RS06735	COG1396	sequence-specific DNA binding
H8S71_RS06745	COG1522	sequence-specific DNA binding
H8S71_RS06750	COG1484	DNA-dependent DNA replication
H8S71_RS06770	COG1595	DNA-templated transcription, initiation
H8S71_RS06775	COG5484	DNA packaging
H8S71_RS06775	COG3728	DNA packaging
H8S71_RS06780	COG1783	phage Terminase large subunit
H8S71_RS06785	COG5518	Phage portal protein
H8S71_RS06790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H8S71_RS06795	COG4653	Phage capsid family
H8S71_RS06845	COG3953	SLT domain
H8S71_RS06845	COG5412	phage tail tape measure protein
H8S71_RS06850	COG1652	LysM domain
H8S71_RS06855	COG4193	domain, Protein
H8S71_RS06865	COG3628	GPW Gp25 family protein
H8S71_RS06870	COG3299	homolog of phage Mu protein gp47
H8S71_RS06875	COG3778	Protein conserved in bacteria
H8S71_RS06915	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS06915	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS06935	COG0306	phosphate transporter
H8S71_RS06940	COG1392	Phosphate transport regulator
H8S71_RS06945	COG0531	amino acid
H8S71_RS06950	COG0346	lactoylglutathione lyase activity
H8S71_RS06955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8S71_RS06960	COG0463	Glycosyl transferase, family 2
H8S71_RS06970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_RS06975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_RS06980	COG2362	D-Aminopeptidase
H8S71_RS06985	COG0601	transmembrane transport
H8S71_RS06990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H8S71_RS06995	COG0444	Belongs to the ABC transporter superfamily
H8S71_RS07000	COG4166	transmembrane transport
H8S71_RS07005	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8S71_RS07010	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_RS07015	COG0791	NLP P60 protein
H8S71_RS07020	COG4608	Belongs to the ABC transporter superfamily
H8S71_RS07025	COG2706	6-phosphogluconolactonase activity
H8S71_RS07030	COG1834	amidinotransferase
H8S71_RS07035	COG1607	acyl-coa hydrolase
H8S71_RS07040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H8S71_RS07040	COG1017	nitric oxide dioxygenase activity
H8S71_RS07050	COG2323	membrane
H8S71_RS07055	COG2318	DinB family
H8S71_RS07060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS07065	COG2076	Multidrug Resistance protein
H8S71_RS07070	COG2076	Multidrug Resistance protein
H8S71_RS07075	COG0788	formyltetrahydrofolate deformylase activity
H8S71_RS07080	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8S71_RS07085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H8S71_RS07090	COG1764	response to oxidative stress
H8S71_RS07095	COG1846	Transcriptional regulator
H8S71_RS07100	COG1764	response to oxidative stress
H8S71_RS07110	COG0590	tRNA wobble adenosine to inosine editing
H8S71_RS07115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_RS07120	COG1404	Belongs to the peptidase S8 family
H8S71_RS07125	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS07130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H8S71_RS07135	COG1122	ATPase activity
H8S71_RS07140	COG4721	ABC-type cobalt transport system, permease component
H8S71_RS07150	COG0745	RESPONSE REGULATOR receiver
H8S71_RS07155	COG5002	protein histidine kinase activity
H8S71_RS07155	COG3850	Histidine kinase
H8S71_RS07160	COG3212	peptidase
H8S71_RS07165	COG3212	peptidase
H8S71_RS07175	COG2239	Acts as a magnesium transporter
H8S71_RS07180	COG0789	Transcriptional regulator
H8S71_RS07195	COG1846	Transcriptional regulator
H8S71_RS07200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_RS07205	COG0726	polysaccharide deacetylase
H8S71_RS07210	COG1408	metallophosphoesterase
H8S71_RS07220	COG0463	Glycosyl transferase, family 2
H8S71_RS07225	COG1793	dna ligase
H8S71_RS07225	COG3285	dna ligase
H8S71_RS07230	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H8S71_RS07240	COG0586	Pfam SNARE associated Golgi protein
H8S71_RS07245	COG0861	Integral membrane protein TerC family
H8S71_RS07250	COG1191	sigma factor activity
H8S71_RS07270	COG0501	Belongs to the peptidase M48B family
H8S71_RS07275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8S71_RS07290	COG3594	Acyltransferase
H8S71_RS07295	COG5002	protein histidine kinase activity
H8S71_RS07300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H8S71_RS07310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H8S71_RS07315	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
H8S71_RS07320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H8S71_RS07325	COG0436	Aminotransferase
H8S71_RS07330	COG1850	ribulose-bisphosphate carboxylase activity
H8S71_RS07335	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
H8S71_RS07340	COG0235	Class ii aldolase
H8S71_RS07345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H8S71_RS07350	COG3339	Conserved Protein
H8S71_RS07365	COG3852	Histidine kinase
H8S71_RS07370	COG1846	Transcriptional regulator
H8S71_RS07375	COG1360	Flagellar Motor Protein
H8S71_RS07380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8S71_RS07385	COG0542	response to heat
H8S71_RS07390	COG3949	Membrane
H8S71_RS07395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H8S71_RS07400	COG0720	synthase
H8S71_RS07405	COG0602	queuosine metabolic process
H8S71_RS07410	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H8S71_RS07415	COG1733	regulation of RNA biosynthetic process
H8S71_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS07425	COG4641	Protein conserved in bacteria
H8S71_RS07425	COG1388	LysM domain
H8S71_RS07430	COG1388	LysM domain
H8S71_RS07435	COG3858	chitin binding
H8S71_RS07445	COG4873	Protein conserved in bacteria
H8S71_RS07455	COG3773	Cell wall hydrolase
H8S71_RS07460	COG2244	polysaccharide biosynthetic process
H8S71_RS07465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS07470	COG2217	Heavy metal translocating P-type atpase
H8S71_RS07480	COG0006	proline dipeptidase activity
H8S71_RS07485	COG1609	Transcriptional regulator
H8S71_RS07490	COG3711	transcriptional antiterminator
H8S71_RS07495	COG1263	PTS System
H8S71_RS07495	COG2190	(PTS) system
H8S71_RS07495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS07500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS07505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H8S71_RS07515	COG1533	DNA photolyase activity
H8S71_RS07520	COG0456	acetyltransferase
H8S71_RS07525	COG0840	transmembrane signaling receptor activity
H8S71_RS07530	COG2084	Dehydrogenase
H8S71_RS07535	COG4257	antibiotic catabolic process
H8S71_RS07540	COG2340	Cysteine-rich secretory protein family
H8S71_RS07545	COG0768	penicillin binding
H8S71_RS07550	COG4191	Histidine kinase
H8S71_RS07555	COG0436	Aminotransferase
H8S71_RS07565	COG0784	Response regulator, receiver
H8S71_RS07565	COG0835	chemotaxis
H8S71_RS07575	COG2814	Major facilitator Superfamily
H8S71_RS07580	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_RS07585	COG1408	metallophosphoesterase
H8S71_RS07590	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS07595	COG2200	EAL domain
H8S71_RS07600	COG4703	Protein of unknown function (DUF1797)
H8S71_RS07605	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H8S71_RS07615	COG0517	IMP dehydrogenase activity
H8S71_RS07620	COG0583	DNA-binding transcription factor activity
H8S71_RS07625	COG0716	FMN binding
H8S71_RS07635	COG0716	FMN binding
H8S71_RS07640	COG2171	N-acyltransferase activity
H8S71_RS07645	COG1473	amidohydrolase
H8S71_RS07655	COG0668	transmembrane transport
H8S71_RS07660	COG0450	alkyl hydroperoxide reductase
H8S71_RS07665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS07680	COG0746	molybdenum cofactor guanylyltransferase activity
H8S71_RS07685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H8S71_RS07690	COG0303	'Molybdopterin
H8S71_RS07695	COG1763	Mo-molybdopterin cofactor biosynthetic process
H8S71_RS07700	COG0314	molybdopterin synthase activity
H8S71_RS07705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H8S71_RS07710	COG1132	(ABC) transporter
H8S71_RS07715	COG1132	(ABC) transporter
H8S71_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8S71_RS07730	COG1136	(ABC) transporter
H8S71_RS07735	COG0577	efflux transmembrane transporter activity
H8S71_RS07740	COG1349	DNA-binding transcription factor activity
H8S71_RS07745	COG1105	Belongs to the carbohydrate kinase PfkB family
H8S71_RS07750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_RS07750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS07750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H8S71_RS07755	COG0681	Belongs to the peptidase S26 family
H8S71_RS07765	COG0488	(ABC) transporter
H8S71_RS07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8S71_RS07775	COG2309	aminopeptidase activity
H8S71_RS07785	COG1077	Cell shape determining protein MreB Mrl
H8S71_RS07790	COG2002	toxin-antitoxin pair type II binding
H8S71_RS07795	COG3852	Histidine kinase
H8S71_RS07800	COG2105	PFAM AIG2 family protein
H8S71_RS07800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
H8S71_RS07805	COG0569	domain protein
H8S71_RS07810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H8S71_RS07815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8S71_RS07820	COG5503	Protein of unknown function (DUF1447)
H8S71_RS07825	COG0561	phosphatase activity
H8S71_RS07830	COG0242	peptide deformylase activity
H8S71_RS07840	COG0497	DNA recombination
H8S71_RS07845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_RS07850	COG0022	dehydrogenase e1 component
H8S71_RS07855	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_RS07860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_RS07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS07875	COG1982	Orn Lys Arg decarboxylase major
H8S71_RS07880	COG4476	Belongs to the UPF0223 family
H8S71_RS07885	COG4493	Belongs to the UPF0637 family
H8S71_RS07895	COG0483	inositol monophosphate 1-phosphatase activity
H8S71_RS07905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H8S71_RS07925	COG1595	DNA-templated transcription, initiation
H8S71_RS07945	COG1217	gtp-binding protein TYPA
H8S71_RS07955	COG4896	Protein conserved in bacteria
H8S71_RS07965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H8S71_RS07970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8S71_RS07975	COG2066	Belongs to the glutaminase family
H8S71_RS07980	COG4838	Belongs to the UPF0358 family
H8S71_RS07985	COG0772	Belongs to the SEDS family
H8S71_RS07990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H8S71_RS07995	COG1612	heme a metabolic process
H8S71_RS08000	COG0109	protoheme IX farnesyltransferase activity
H8S71_RS08005	COG2010	Cytochrome c
H8S71_RS08005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8S71_RS08010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8S71_RS08015	COG1845	cytochrome c oxidase, subunit III
H8S71_RS08020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8S71_RS08025	COG3336	cytochrome c oxidase
H8S71_RS08035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H8S71_RS08040	COG2340	Cysteine-rich secretory protein family
H8S71_RS08055	COG3679	Belongs to the UPF0342 family
H8S71_RS08060	COG4471	UPF0298 protein
H8S71_RS08065	COG0742	ribosomal rna small subunit methyltransferase
H8S71_RS08070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H8S71_RS08075	COG3314	Sporulation integral membrane protein YlbJ
H8S71_RS08080	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8S71_RS08085	COG3480	Lon protease (S16) C-terminal proteolytic domain
H8S71_RS08090	COG1323	Belongs to the UPF0348 family
H8S71_RS08100	COG1399	metal-binding, possibly nucleic acid-binding protein
H8S71_RS08115	COG0454	-acetyltransferase
H8S71_RS08120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H8S71_RS08125	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H8S71_RS08130	COG2001	Belongs to the MraZ family
H8S71_RS08135	COG0275	rRNA processing
H8S71_RS08140	COG4839	cell division protein FtsL
H8S71_RS08145	COG0768	penicillin binding
H8S71_RS08150	COG0768	penicillin binding
H8S71_RS08155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H8S71_RS08160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8S71_RS08165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8S71_RS08170	COG0772	Belongs to the SEDS family
H8S71_RS08175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_RS08180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H8S71_RS08185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H8S71_RS08190	COG3879	Bacterial protein of unknown function (DUF881)
H8S71_RS08195	COG3879	Bacterial protein of unknown function (DUF881)
H8S71_RS08200	COG3856	small basic protein
H8S71_RS08205	COG0849	cell division
H8S71_RS08210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H8S71_RS08215	COG4412	M6 family metalloprotease domain protein
H8S71_RS08215	COG1404	Belongs to the peptidase S8 family
H8S71_RS08225	COG1191	sigma factor activity
H8S71_RS08230	COG1191	sigma factor activity
H8S71_RS08235	COG1119	ATPase activity
H8S71_RS08240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_RS08245	COG1873	PFAM PRC-barrel domain
H8S71_RS08250	COG1496	oxidoreductase activity
H8S71_RS08255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H8S71_RS08260	COG1799	cell septum assembly
H8S71_RS08265	COG0762	integral membrane protein
H8S71_RS08270	COG2302	S4 RNA-binding domain
H8S71_RS08275	COG3599	regulation of cell shape
H8S71_RS08280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H8S71_RS08285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_RS08290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H8S71_RS08295	COG0564	pseudouridine synthase activity
H8S71_RS08300	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H8S71_RS08305	COG2233	PERMEase
H8S71_RS08310	COG0540	Belongs to the ATCase OTCase family
H8S71_RS08315	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8S71_RS08320	COG0505	Belongs to the CarA family
H8S71_RS08325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H8S71_RS08330	COG0543	2 iron, 2 sulfur cluster binding
H8S71_RS08335	COG0167	dihydroorotate dehydrogenase activity
H8S71_RS08340	COG0284	orotidine-5'-phosphate decarboxylase activity
H8S71_RS08345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H8S71_RS08350	COG0175	sulfate reduction
H8S71_RS08355	COG0306	phosphate transporter
H8S71_RS08360	COG2046	Belongs to the sulfate adenylyltransferase family
H8S71_RS08365	COG0529	Catalyzes the synthesis of activated sulfate
H8S71_RS08370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H8S71_RS08375	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
H8S71_RS08380	COG1648	precorrin-2 dehydrogenase activity
H8S71_RS08385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H8S71_RS08390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8S71_RS08395	COG1561	YicC-like family, N-terminal region
H8S71_RS08405	COG0194	GDP metabolic process
H8S71_RS08410	COG1758	RNA polymerase activity
H8S71_RS08415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8S71_RS08420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H8S71_RS08425	COG0242	peptide deformylase activity
H8S71_RS08430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H8S71_RS08435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H8S71_RS08435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8S71_RS08440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H8S71_RS08445	COG0631	protein serine/threonine phosphatase activity
H8S71_RS08450	COG0515	serine threonine protein kinase
H8S71_RS08450	COG2815	serine threonine protein kinase
H8S71_RS08455	COG1162	GTPase activity
H8S71_RS08460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H8S71_RS08465	COG1564	THIamine pyrophosphokinase
H8S71_RS08475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H8S71_RS08480	COG1302	Protein conserved in bacteria
H8S71_RS08485	COG1461	Dihydroxyacetone kinase
H8S71_RS08490	COG1760	l-serine dehydratase
H8S71_RS08495	COG1760	l-serine dehydratase
H8S71_RS08500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H8S71_RS08505	COG2050	protein possibly involved in aromatic compounds catabolism
H8S71_RS08505	COG1349	DNA-binding transcription factor activity
H8S71_RS08510	COG0416	fatty acid biosynthetic process
H8S71_RS08515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS08530	COG0571	ribonuclease III activity
H8S71_RS08535	COG1196	nuclear chromosome segregation
H8S71_RS08540	COG0552	protein localization to endoplasmic reticulum
H8S71_RS08550	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H8S71_RS08555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H8S71_RS08560	COG0228	four-way junction DNA binding
H8S71_RS08565	COG1837	Belongs to the UPF0109 family
H8S71_RS08575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H8S71_RS08580	COG0336	Belongs to the RNA methyltransferase TrmD family
H8S71_RS08585	COG0335	large ribosomal subunit rRNA binding
H8S71_RS08590	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H8S71_RS08595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8S71_RS08605	COG2257	FlhB HrpN YscU SpaS Family
H8S71_RS08610	COG0045	succinate-CoA ligase (ADP-forming) activity
H8S71_RS08615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H8S71_RS08620	COG0758	DNA mediated transformation
H8S71_RS08625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H8S71_RS08630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H8S71_RS08635	COG4974	Belongs to the 'phage' integrase family
H8S71_RS08640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H8S71_RS08645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H8S71_RS08650	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H8S71_RS08655	COG1815	bacterial-type flagellum-dependent cell motility
H8S71_RS08660	COG1558	bacterial-type flagellum-dependent cell motility
H8S71_RS08665	COG1677	Flagellar hook-basal body complex protein FliE
H8S71_RS08670	COG1766	The M ring may be actively involved in energy transduction
H8S71_RS08675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_RS08680	COG1317	bacterial-type flagellum organization
H8S71_RS08685	COG1157	protein secretion by the type III secretion system
H8S71_RS08690	COG2882	bacterial-type flagellum organization
H8S71_RS08695	COG3334	PFAM MgtE intracellular
H8S71_RS08700	COG3144	bacterial-type flagellum assembly
H8S71_RS08705	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H8S71_RS08710	COG4786	Flagellar basal body rod
H8S71_RS08715	COG1582	Flagellar protein (FlbD)
H8S71_RS08720	COG1580	Controls the rotational direction of flagella during chemotaxis
H8S71_RS08725	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_RS08730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H8S71_RS08730	COG1776	CheC inhibitor of MCP methylation
H8S71_RS08735	COG2201	protein-glutamate methylesterase activity
H8S71_RS08740	COG3190	flagellar
H8S71_RS08745	COG1338	Plays a role in the flagellum-specific transport system
H8S71_RS08750	COG1987	bacterial-type flagellum assembly
H8S71_RS08755	COG1684	flagellar biosynthetic protein fliR
H8S71_RS08760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8S71_RS08765	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H8S71_RS08770	COG1419	protein localization to endoplasmic reticulum
H8S71_RS08775	COG0455	bacterial-type flagellum organization
H8S71_RS08780	COG2201	protein-glutamate methylesterase activity
H8S71_RS08785	COG2198	Histidine kinase
H8S71_RS08785	COG0643	Histidine kinase
H8S71_RS08790	COG0835	chemotaxis
H8S71_RS08795	COG1776	CheC inhibitor of MCP methylation
H8S71_RS08800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H8S71_RS08805	COG1191	sigma factor activity
H8S71_RS08815	COG0052	Belongs to the universal ribosomal protein uS2 family
H8S71_RS08820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H8S71_RS08825	COG0528	UMP kinase activity
H8S71_RS08830	COG0233	cytoplasmic translational termination
H8S71_RS08835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H8S71_RS08840	COG4589	Belongs to the CDS family
H8S71_RS08845	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H8S71_RS08850	COG0750	zinc metalloprotease
H8S71_RS08855	COG0442	prolyl-tRNA aminoacylation
H8S71_RS08860	COG2176	DNA-directed DNA polymerase activity
H8S71_RS08865	COG0779	Required for maturation of 30S ribosomal subunits
H8S71_RS08870	COG0195	Participates in both transcription termination and antitermination
H8S71_RS08875	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H8S71_RS08880	COG1358	cellular component organization or biogenesis
H8S71_RS08885	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H8S71_RS08890	COG1550	Protein conserved in bacteria
H8S71_RS08895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H8S71_RS08900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H8S71_RS08905	COG0196	riboflavin kinase activity
H8S71_RS08910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H8S71_RS08915	COG1185	polyribonucleotide nucleotidyltransferase activity
H8S71_RS08920	COG0726	polysaccharide deacetylase
H8S71_RS08925	COG0612	Peptidase, M16
H8S71_RS08930	COG1873	PFAM PRC-barrel domain
H8S71_RS08935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8S71_RS08940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H8S71_RS08945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H8S71_RS08950	COG0527	aspartate kinase activity
H8S71_RS08955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H8S71_RS08960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H8S71_RS08965	COG0740	serine-type endopeptidase activity
H8S71_RS08975	COG4980	gas vesicle protein
H8S71_RS08975	COG1674	ftsk spoiiie
H8S71_RS08980	COG2188	Transcriptional regulator
H8S71_RS08985	COG2814	Major facilitator Superfamily
H8S71_RS08990	COG0612	Peptidase, M16
H8S71_RS08995	COG0612	Peptidase, M16
H8S71_RS09000	COG0300	oxidoreductase activity
H8S71_RS09015	COG1426	Protein conserved in bacteria
H8S71_RS09020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H8S71_RS09025	COG1546	Belongs to the CinA family
H8S71_RS09025	COG1058	Belongs to the CinA family
H8S71_RS09030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H8S71_RS09035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_RS09040	COG1418	mRNA catabolic process
H8S71_RS09045	COG1692	metallophosphoesterase
H8S71_RS09050	COG2359	stage V sporulation protein S
H8S71_RS09055	COG1063	alcohol dehydrogenase
H8S71_RS09060	COG0156	8-amino-7-oxononanoate synthase activity
H8S71_RS09065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8S71_RS09070	COG4550	Control of competence regulator ComK, YlbF/YmcA
H8S71_RS09080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H8S71_RS09085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H8S71_RS09100	COG3226	Transcriptional regulator
H8S71_RS09105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS09115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_RS09120	COG3321	synthase
H8S71_RS09125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H8S71_RS09125	COG2070	2-Nitropropane dioxygenase
H8S71_RS09130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_RS09135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H8S71_RS09140	COG3425	synthase
H8S71_RS09145	COG1024	Enoyl-CoA hydratase
H8S71_RS09150	COG1024	Enoyl-CoA hydratase
H8S71_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS09155	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS09155	COG0300	oxidoreductase activity
H8S71_RS09155	COG3321	synthase
H8S71_RS09155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09160	COG0300	oxidoreductase activity
H8S71_RS09160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_RS09160	COG3321	synthase
H8S71_RS09160	COG4221	oxidoreductase activity
H8S71_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS09165	COG3321	synthase
H8S71_RS09165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS09170	COG3321	synthase
H8S71_RS09170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09170	COG4221	oxidoreductase activity
H8S71_RS09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_RS09175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H8S71_RS09175	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H8S71_RS09175	COG3321	synthase
H8S71_RS09180	COG2124	cytochrome p450
H8S71_RS09190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS09195	COG1404	Belongs to the peptidase S8 family
H8S71_RS09205	COG4195	phage-related replication protein
H8S71_RS09210	COG1764	response to oxidative stress
H8S71_RS09215	COG2076	Multidrug Resistance protein
H8S71_RS09220	COG2076	Multidrug Resistance protein
H8S71_RS09235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H8S71_RS09240	COG1923	regulation of RNA biosynthetic process
H8S71_RS09255	COG1780	Probably involved in ribonucleotide reductase function
H8S71_RS09260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8S71_RS09265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H8S71_RS09270	COG4112	unkown
H8S71_RS09275	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS09280	COG0464	growth
H8S71_RS09285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H8S71_RS09290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H8S71_RS09295	COG0789	Transcriptional regulator
H8S71_RS09300	COG0174	glutamine synthetase
H8S71_RS09325	COG4282	regulation of fungal-type cell wall biogenesis
H8S71_RS09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS09345	COG0135	phosphoribosylanthranilate isomerase activity
H8S71_RS09350	COG2211	Major facilitator Superfamily
H8S71_RS09355	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_RS09360	COG1940	carbohydrate kinase activity
H8S71_RS09365	COG2115	Belongs to the xylose isomerase family
H8S71_RS09370	COG1070	Carbohydrate kinase
H8S71_RS09380	COG1525	nuclease
H8S71_RS09385	COG2814	Major facilitator Superfamily
H8S71_RS09390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H8S71_RS09400	COG0756	dUTP diphosphatase activity
H8S71_RS09440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H8S71_RS09455	COG3832	glyoxalase III activity
H8S71_RS09465	COG0697	spore germination
H8S71_RS09470	COG0531	amino acid
H8S71_RS09500	COG4195	phage-related replication protein
H8S71_RS09510	COG0346	lactoylglutathione lyase activity
H8S71_RS09515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H8S71_RS09520	COG1388	LysM domain
H8S71_RS09525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_RS09530	COG4224	UPF0291 protein
H8S71_RS09535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8S71_RS09545	COG3763	UPF0154 protein
H8S71_RS09555	COG0785	Cytochrome C biogenesis protein
H8S71_RS09560	COG2201	protein-glutamate methylesterase activity
H8S71_RS09565	COG4846	Membrane protein involved in cytochrome C biogenesis
H8S71_RS09575	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_RS09590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H8S71_RS09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS09615	COG0824	Thioesterase
H8S71_RS09625	COG4841	protein insertion into membrane
H8S71_RS09630	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H8S71_RS09635	COG1832	CoA-binding protein
H8S71_RS09640	COG0187	DNA topoisomerase II activity
H8S71_RS09645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H8S71_RS09655	COG1115	amino acid carrier protein
H8S71_RS09660	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
H8S71_RS09670	COG5520	Belongs to the glycosyl hydrolase 30 family
H8S71_RS09675	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_RS09680	COG2246	polysaccharide biosynthetic process
H8S71_RS09685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_RS09690	COG0586	Pfam SNARE associated Golgi protein
H8S71_RS09695	COG2404	hydrolase activity, acting on ester bonds
H8S71_RS09700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8S71_RS09705	COG1024	Enoyl-CoA hydratase
H8S71_RS09710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8S71_RS09715	COG0511	ligase activity, forming carbon-carbon bonds
H8S71_RS09720	COG0439	Biotin carboxylase
H8S71_RS09725	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS09730	COG1960	acyl-CoA dehydrogenase activity
H8S71_RS09740	COG1649	PFAM Uncharacterised BCR, COG1649
H8S71_RS09750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09750	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H8S71_RS09755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS09775	COG2027	D-alanyl-D-alanine carboxypeptidase
H8S71_RS09780	COG2017	converts alpha-aldose to the beta-anomer
H8S71_RS09785	COG0534	Mate efflux family protein
H8S71_RS09800	COG0582	viral genome integration into host DNA
H8S71_RS09805	COG0166	Belongs to the GPI family
H8S71_RS09810	COG0405	Gamma-glutamyltransferase
H8S71_RS09815	COG0583	DNA-binding transcription factor activity
H8S71_RS09820	COG0604	alcohol dehydrogenase
H8S71_RS09825	COG0493	'glutamate synthase
H8S71_RS09830	COG0070	glutamate synthase
H8S71_RS09830	COG0069	glutamate synthase activity
H8S71_RS09830	COG0067	glutamate synthase
H8S71_RS09835	COG0583	DNA-binding transcription factor activity
H8S71_RS09840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H8S71_RS09845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_RS09855	COG0300	oxidoreductase activity
H8S71_RS09860	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H8S71_RS09870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H8S71_RS09875	COG2814	Major facilitator Superfamily
H8S71_RS09880	COG1070	Carbohydrate kinase
H8S71_RS09885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8S71_RS09890	COG0243	molybdopterin cofactor binding
H8S71_RS09920	COG0840	transmembrane signaling receptor activity
H8S71_RS09920	COG5278	phosphoserine phosphatase activity
H8S71_RS09925	COG2368	4-hydroxyphenylacetate
H8S71_RS09930	COG4305	rare lipoprotein A
H8S71_RS09935	COG3619	membrane
H8S71_RS09940	COG3866	Pectate lyase
H8S71_RS09945	COG2135	peptidase activity
H8S71_RS09955	COG2140	Oxalate decarboxylase
H8S71_RS09985	COG2720	vancomycin resistance protein
H8S71_RS10000	COG3739	integral membrane protein
H8S71_RS10005	COG0583	DNA-binding transcription factor activity
H8S71_RS10010	COG0697	spore germination
H8S71_RS10020	COG0693	protein deglycase activity
H8S71_RS10025	COG2367	Beta-lactamase
H8S71_RS10040	COG0574	Belongs to the PEP-utilizing enzyme family
H8S71_RS10040	COG3848	Pyruvate phosphate dikinase
H8S71_RS10045	COG0726	polysaccharide deacetylase
H8S71_RS10050	COG1793	dna ligase
H8S71_RS10085	COG5444	nuclease activity
H8S71_RS10090	COG4282	regulation of fungal-type cell wall biogenesis
H8S71_RS10095	COG1231	oxidoreductase activity
H8S71_RS10105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_RS10110	COG0662	Cupin 2, conserved barrel domain protein
H8S71_RS10110	COG2207	Transcriptional regulator
H8S71_RS10115	COG0456	acetyltransferase
H8S71_RS10120	COG1309	transcriptional regulator
H8S71_RS10125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS10130	COG3708	Transcriptional regulator
H8S71_RS10135	COG2378	regulation of single-species biofilm formation
H8S71_RS10145	COG0640	Transcriptional regulator
H8S71_RS10150	COG0741	lytic transglycosylase activity
H8S71_RS10155	COG2322	membrane
H8S71_RS10170	COG1619	proteins homologs of microcin C7 resistance protein MccF
H8S71_RS10175	COG3239	Fatty acid desaturase
H8S71_RS10180	COG4585	Histidine kinase
H8S71_RS10185	COG2197	response regulator
H8S71_RS10190	COG3584	3D domain protein
H8S71_RS10190	COG1388	LysM domain
H8S71_RS10195	COG0514	ATP-dependent DNA helicase (RecQ)
H8S71_RS10205	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8S71_RS10210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_RS10225	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_RS10250	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS10255	COG1657	PFAM Prenyltransferase squalene oxidase
H8S71_RS10260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8S71_RS10265	COG0733	neurotransmitter:sodium symporter activity
H8S71_RS10270	COG0385	Bile acid
H8S71_RS10275	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_RS10280	COG0567	Dehydrogenase, E1 component
H8S71_RS10285	COG4548	von Willebrand factor, type A
H8S71_RS10290	COG0714	Associated with various cellular activities
H8S71_RS10295	COG2032	superoxide dismutase activity
H8S71_RS10300	COG0791	NLP P60 protein
H8S71_RS10300	COG1388	LysM domain
H8S71_RS10305	COG1819	glycosyl
H8S71_RS10310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H8S71_RS10315	COG0534	Mate efflux family protein
H8S71_RS10320	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS10325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_RS10330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_RS10340	COG2962	Rard protein
H8S71_RS10355	COG2610	gluconate transmembrane transporter activity
H8S71_RS10360	COG1942	4-Oxalocrotonate Tautomerase
H8S71_RS10365	COG1733	regulation of RNA biosynthetic process
H8S71_RS10370	COG0778	Nitroreductase
H8S71_RS10375	COG0400	carboxylic ester hydrolase activity
H8S71_RS10380	COG0346	lactoylglutathione lyase activity
H8S71_RS10390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_RS10395	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS10395	COG0793	Belongs to the peptidase S41A family
H8S71_RS10400	COG2226	methyltransferase
H8S71_RS10410	COG1876	peptidase activity
H8S71_RS10415	COG0813	purine-nucleoside phosphorylase activity
H8S71_RS10430	COG0671	phosphoesterase, PA-phosphatase related
H8S71_RS10450	COG4479	Belongs to the UPF0346 family
H8S71_RS10460	COG1509	lysine 2,3-aminomutase activity
H8S71_RS10465	COG0456	acetyltransferase
H8S71_RS10470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_RS10475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8S71_RS10480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8S71_RS10485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_RS10500	COG0456	acetyltransferase
H8S71_RS10505	COG0463	Glycosyl transferase, family 2
H8S71_RS10520	COG4641	Protein conserved in bacteria
H8S71_RS10525	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
H8S71_RS10530	COG1086	Polysaccharide biosynthesis protein
H8S71_RS10535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8S71_RS10540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H8S71_RS10545	COG1846	Transcriptional regulator
H8S71_RS10550	COG0534	Mate efflux family protein
H8S71_RS10560	COG4698	Protein conserved in bacteria
H8S71_RS10565	COG2755	lipolytic protein G-D-S-L family
H8S71_RS10570	COG1999	signal sequence binding
H8S71_RS10580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H8S71_RS10585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8S71_RS10590	COG1272	protein, Hemolysin III
H8S71_RS10595	COG0204	Acyl-transferase
H8S71_RS10600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_RS10605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8S71_RS10615	COG2136	Putative SAM-dependent methyltransferase
H8S71_RS10615	COG2521	methyltransferase
H8S71_RS10625	COG0129	dihydroxy-acid dehydratase activity
H8S71_RS10630	COG1413	lyase activity
H8S71_RS10635	COG1418	mRNA catabolic process
H8S71_RS10640	COG0386	Belongs to the glutathione peroxidase family
H8S71_RS10645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H8S71_RS10650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H8S71_RS10660	COG1278	Cold shock
H8S71_RS10680	COG0328	RNA-DNA hybrid ribonuclease activity
H8S71_RS10685	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H8S71_RS10690	COG0328	RNA-DNA hybrid ribonuclease activity
H8S71_RS10700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_RS10715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H8S71_RS10730	COG3424	synthase
H8S71_RS10735	COG2233	PERMEase
H8S71_RS10740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_RS10745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H8S71_RS10755	COG0800	Aldolase
H8S71_RS10760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_RS10765	COG1609	Transcriptional regulator
H8S71_RS10770	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H8S71_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS10780	COG1199	ATP-dependent helicase activity
H8S71_RS10795	COG0116	Belongs to the methyltransferase superfamily
H8S71_RS10810	COG4474	Belongs to the UPF0398 family
H8S71_RS10825	COG3359	exonuclease
H8S71_RS10830	COG1205	dead DEAH box helicase
H8S71_RS10830	COG1111	helicase
H8S71_RS10835	COG2190	(PTS) system
H8S71_RS10840	COG0071	Belongs to the small heat shock protein (HSP20) family
H8S71_RS10875	COG3331	DNA recombination
H8S71_RS10880	COG4499	WXG100 protein secretion system (Wss), protein YukC
H8S71_RS10880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_RS10890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H8S71_RS10895	COG3935	DnaD domain protein
H8S71_RS10900	COG0017	Asparaginyl-tRNA synthetase
H8S71_RS10905	COG0436	Aminotransferase
H8S71_RS10910	COG5353	protein conserved in bacteria
H8S71_RS10920	COG1199	ATP-dependent helicase activity
H8S71_RS10920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H8S71_RS10925	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H8S71_RS10930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H8S71_RS10935	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H8S71_RS10940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H8S71_RS10940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H8S71_RS10945	COG0617	tRNA 3'-terminal CCA addition
H8S71_RS10950	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H8S71_RS10960	COG1803	Methylglyoxal synthase
H8S71_RS10965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H8S71_RS10970	COG1694	Mazg nucleotide pyrophosphohydrolase
H8S71_RS10975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS10985	COG4347	Protein of unknown function (DUF1405)
H8S71_RS10990	COG2010	Cytochrome c
H8S71_RS10990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8S71_RS10995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H8S71_RS11000	COG0723	plastoquinol--plastocyanin reductase activity
H8S71_RS11010	COG5582	Belongs to the UPF0302 family
H8S71_RS11015	COG0457	Tetratricopeptide repeat
H8S71_RS11020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H8S71_RS11025	COG0287	Prephenate dehydrogenase
H8S71_RS11035	COG0159	tryptophan synthase activity
H8S71_RS11040	COG0133	tryptophan synthase activity
H8S71_RS11045	COG0135	phosphoribosylanthranilate isomerase activity
H8S71_RS11055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H8S71_RS11060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H8S71_RS11065	COG4401	Chorismate mutase type I
H8S71_RS11070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H8S71_RS11075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H8S71_RS11080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H8S71_RS11085	COG0105	UTP biosynthetic process
H8S71_RS11090	COG0142	geranyltranstransferase activity
H8S71_RS11095	COG2226	methyltransferase
H8S71_RS11100	COG0142	geranyltranstransferase activity
H8S71_RS11110	COG0302	gtp cyclohydrolase
H8S71_RS11115	COG0776	regulation of translation
H8S71_RS11120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H8S71_RS11135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H8S71_RS11140	COG1160	GTP binding
H8S71_RS11165	COG1304	FMN binding
H8S71_RS11170	COG0539	negative regulation of cytoplasmic translation
H8S71_RS11175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H8S71_RS11185	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H8S71_RS11190	COG2959	enzyme of heme biosynthesis
H8S71_RS11195	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS11195	COG3773	Cell wall hydrolase
H8S71_RS11200	COG2339	peptidase activity
H8S71_RS11205	COG0492	ferredoxin-NADP+ reductase activity
H8S71_RS11210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_RS11215	COG4862	establishment of competence for transformation
H8S71_RS11220	COG1408	metallophosphoesterase
H8S71_RS11230	COG1388	LysM domain
H8S71_RS11235	COG1266	CAAX protease self-immunity
H8S71_RS11240	COG0514	ATP-dependent DNA helicase (RecQ)
H8S71_RS11245	COG4955	Helix-turn-helix domain
H8S71_RS11250	COG1141	Ferredoxin
H8S71_RS11255	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H8S71_RS11260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H8S71_RS11265	COG0710	3-dehydroquinate dehydratase activity
H8S71_RS11275	COG1595	DNA-templated transcription, initiation
H8S71_RS11280	COG5002	protein histidine kinase activity
H8S71_RS11285	COG0745	RESPONSE REGULATOR receiver
H8S71_RS11290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8S71_RS11295	COG1333	cytochrome c biogenesis protein
H8S71_RS11300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS11305	COG1187	pseudouridine synthase activity
H8S71_RS11310	COG0700	Nucleoside recognition
H8S71_RS11315	COG2715	membrane protein required for spore maturation
H8S71_RS11320	COG1686	Belongs to the peptidase S11 family
H8S71_RS11330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H8S71_RS11335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H8S71_RS11340	COG1547	Domain of unknown function (DUF309)
H8S71_RS11345	COG0456	acetyltransferase
H8S71_RS11350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H8S71_RS11355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8S71_RS11355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H8S71_RS11360	COG0307	riboflavin synthase, alpha
H8S71_RS11365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8S71_RS11365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H8S71_RS11375	COG0681	Belongs to the peptidase S26 family
H8S71_RS11385	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
H8S71_RS11415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H8S71_RS11420	COG4086	secreted protein
H8S71_RS11425	COG0019	diaminopimelate decarboxylase activity
H8S71_RS11430	COG0697	spore germination
H8S71_RS11445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H8S71_RS11465	COG1191	sigma factor activity
H8S71_RS11470	COG2172	sigma factor antagonist activity
H8S71_RS11475	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS11480	COG1686	Belongs to the peptidase S11 family
H8S71_RS11485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H8S71_RS11490	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H8S71_RS11495	COG4974	Belongs to the 'phage' integrase family
H8S71_RS11505	COG0735	belongs to the Fur family
H8S71_RS11510	COG1300	Membrane
H8S71_RS11520	COG0281	malic enzyme
H8S71_RS11525	COG1757	Na H antiporter
H8S71_RS11530	COG1027	Aspartate ammonia-lyase
H8S71_RS11535	COG0252	asparaginase activity
H8S71_RS11540	COG1396	sequence-specific DNA binding
H8S71_RS11545	COG1379	DNA repair
H8S71_RS11550	COG0494	nUDIX hydrolase
H8S71_RS11560	COG0667	Aldo Keto reductase
H8S71_RS11570	COG1073	alpha beta
H8S71_RS11580	COG4918	Iron-sulphur cluster biosynthesis
H8S71_RS11585	COG0456	acetyltransferase
H8S71_RS11585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H8S71_RS11590	COG2329	Antibiotic biosynthesis monooxygenase
H8S71_RS11595	COG0456	acetyltransferase
H8S71_RS11605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8S71_RS11615	COG2211	Major facilitator Superfamily
H8S71_RS11625	COG0346	lactoylglutathione lyase activity
H8S71_RS11630	COG1072	(Pantothenic acid kinase))
H8S71_RS11635	COG3048	D-serine ammonia-lyase activity
H8S71_RS11640	COG0300	oxidoreductase activity
H8S71_RS11645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS11650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_RS11655	COG4187	Peptidase family M20/M25/M40
H8S71_RS11660	COG1902	pentaerythritol trinitrate reductase activity
H8S71_RS11665	COG0596	Alpha beta hydrolase
H8S71_RS11675	COG1234	tRNA 3'-trailer cleavage
H8S71_RS11680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H8S71_RS11685	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8S71_RS11690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H8S71_RS11700	COG0706	membrane insertase activity
H8S71_RS11705	COG3361	conserved protein (COG2071)
H8S71_RS11710	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8S71_RS11715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H8S71_RS11720	COG0346	lactoylglutathione lyase activity
H8S71_RS11730	COG1376	ErfK ybiS ycfS ynhG family protein
H8S71_RS11735	COG4129	membrane
H8S71_RS11740	COG1126	abc transporter atp-binding protein
H8S71_RS11745	COG0765	amino acid transport
H8S71_RS11750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS11760	COG1597	lipid kinase activity
H8S71_RS11765	COG2814	Major facilitator Superfamily
H8S71_RS11770	COG0789	Transcriptional regulator
H8S71_RS11770	COG4978	Transcriptional regulator
H8S71_RS11775	COG0508	dehydrogenase complex catalyzes the overall conversion of
H8S71_RS11780	COG0022	dehydrogenase e1 component
H8S71_RS11785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H8S71_RS11790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H8S71_RS11795	COG3426	butyrate kinase activity
H8S71_RS11800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_RS11805	COG0280	phosphate acetyltransferase
H8S71_RS11810	COG3829	transcription factor binding
H8S71_RS11810	COG3290	protein histidine kinase activity
H8S71_RS11820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H8S71_RS11825	COG2079	MmgE PrpD family protein
H8S71_RS11830	COG0372	Belongs to the citrate synthase family
H8S71_RS11835	COG1960	acyl-CoA dehydrogenase activity
H8S71_RS11840	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8S71_RS11845	COG0183	Belongs to the thiolase family
H8S71_RS11850	COG0584	glycerophosphoryl diester phosphodiesterase
H8S71_RS11855	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS11870	COG1902	pentaerythritol trinitrate reductase activity
H8S71_RS11875	COG0745	RESPONSE REGULATOR receiver
H8S71_RS11880	COG0750	zinc metalloprotease
H8S71_RS11885	COG0497	DNA recombination
H8S71_RS11890	COG1438	arginine binding
H8S71_RS11895	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H8S71_RS11900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H8S71_RS11905	COG0142	geranyltranstransferase activity
H8S71_RS11910	COG1722	exodeoxyribonuclease VII activity
H8S71_RS11915	COG1570	exodeoxyribonuclease VII activity
H8S71_RS11920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H8S71_RS11925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H8S71_RS11930	COG1302	Protein conserved in bacteria
H8S71_RS11935	COG0439	Biotin carboxylase
H8S71_RS11940	COG0511	ligase activity, forming carbon-carbon bonds
H8S71_RS11980	COG3854	ATPases associated with a variety of cellular activities
H8S71_RS11990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H8S71_RS11995	COG0006	proline dipeptidase activity
H8S71_RS12000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H8S71_RS12010	COG3872	metal-dependent enzyme
H8S71_RS12020	COG1752	Esterase of the alpha-beta hydrolase superfamily
H8S71_RS12025	COG1321	iron dependent repressor
H8S71_RS12030	COG0095	Lipoate-protein ligase
H8S71_RS12035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_RS12040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8S71_RS12045	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H8S71_RS12050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H8S71_RS12055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8S71_RS12070	COG1396	sequence-specific DNA binding
H8S71_RS12080	COG0681	Belongs to the peptidase S26 family
H8S71_RS12105	COG4940	Competence protein ComGF
H8S71_RS12115	COG4970	Tfp pilus assembly protein FimT
H8S71_RS12120	COG4537	Required for transformation and DNA binding
H8S71_RS12125	COG1459	type II secretion system
H8S71_RS12130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H8S71_RS12135	COG0598	Magnesium transport protein CorA
H8S71_RS12140	COG1253	flavin adenine dinucleotide binding
H8S71_RS12145	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS12155	COG1393	Belongs to the ArsC family
H8S71_RS12165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS12175	COG0011	TIGRFAM Protein of
H8S71_RS12185	COG2866	Carboxypeptidase
H8S71_RS12190	COG1368	sulfuric ester hydrolase activity
H8S71_RS12195	COG1940	carbohydrate kinase activity
H8S71_RS12200	COG4483	Protein conserved in bacteria
H8S71_RS12205	COG0457	Tetratricopeptide repeat
H8S71_RS12205	COG0705	Rhomboid family
H8S71_RS12215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H8S71_RS12225	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS12240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8S71_RS12245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_RS12250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H8S71_RS12255	COG0581	inorganic phosphate transmembrane transporter activity
H8S71_RS12260	COG0573	inorganic phosphate transmembrane transporter activity
H8S71_RS12265	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H8S71_RS12270	COG0768	penicillin binding
H8S71_RS12275	COG0477	Major facilitator Superfamily
H8S71_RS12280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H8S71_RS12285	COG2839	Protein conserved in bacteria
H8S71_RS12290	COG5521	maltodextrose utilization protein MalA
H8S71_RS12295	COG1388	LysM domain
H8S71_RS12300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H8S71_RS12305	COG4709	membrane
H8S71_RS12310	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
H8S71_RS12315	COG0735	belongs to the Fur family
H8S71_RS12320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS12330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H8S71_RS12335	COG0513	Belongs to the DEAD box helicase family
H8S71_RS12345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H8S71_RS12350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H8S71_RS12355	COG2384	SAM-dependent methyltransferase
H8S71_RS12360	COG2010	Cytochrome c
H8S71_RS12365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H8S71_RS12370	COG0358	DNA primase activity
H8S71_RS12375	COG1671	Belongs to the UPF0178 family
H8S71_RS12380	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H8S71_RS12385	COG0517	IMP dehydrogenase activity
H8S71_RS12390	COG0751	glycine-tRNA ligase activity
H8S71_RS12395	COG0752	glycyl-tRNA synthetase alpha subunit
H8S71_RS12400	COG1381	Involved in DNA repair and RecF pathway recombination
H8S71_RS12410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H8S71_RS12415	COG0295	cytidine deaminase activity
H8S71_RS12420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H8S71_RS12425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H8S71_RS12430	COG1480	7TM receptor with intracellular HD hydrolase
H8S71_RS12435	COG1702	phosphate starvation-inducible protein PhoH
H8S71_RS12440	COG0561	phosphatase activity
H8S71_RS12455	COG4864	UPF0365 protein
H8S71_RS12460	COG1030	water channel activity
H8S71_RS12465	COG1610	YqeY-like protein
H8S71_RS12475	COG1283	sodium-dependent phosphate transmembrane transporter activity
H8S71_RS12480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H8S71_RS12485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H8S71_RS12490	COG2264	protein methyltransferase activity
H8S71_RS12495	COG0484	heat shock protein binding
H8S71_RS12500	COG0443	Heat shock 70 kDa protein
H8S71_RS12505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H8S71_RS12510	COG1420	regulation of RNA biosynthetic process
H8S71_RS12515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H8S71_RS12520	COG0481	GTPase activity
H8S71_RS12530	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS12535	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H8S71_RS12540	COG0268	Binds directly to 16S ribosomal RNA
H8S71_RS12545	COG1466	dna polymerase III delta subunit
H8S71_RS12560	COG2333	competence protein COMEC
H8S71_RS12560	COG0658	competence protein
H8S71_RS12565	COG2131	deaminase
H8S71_RS12570	COG1555	photosystem II stabilization
H8S71_RS12570	COG1596	polysaccharide export
H8S71_RS12575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H8S71_RS12580	COG2226	methyltransferase
H8S71_RS12585	COG0799	negative regulation of ribosome biogenesis
H8S71_RS12590	COG1713	HD superfamily hydrolase involved in NAD metabolism
H8S71_RS12595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H8S71_RS12600	COG1534	Rna-binding protein
H8S71_RS12605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H8S71_RS12610	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H8S71_RS12615	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H8S71_RS12625	COG2755	lipolytic protein G-D-S-L family
H8S71_RS12630	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS12630	COG5632	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS12635	COG0398	Pfam SNARE associated Golgi protein
H8S71_RS12640	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H8S71_RS12650	COG3209	COG3209 Rhs family protein
H8S71_RS12665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_RS12670	COG3223	Belongs to the PsiE family
H8S71_RS12675	COG5002	protein histidine kinase activity
H8S71_RS12675	COG0642	Histidine kinase
H8S71_RS12680	COG0745	RESPONSE REGULATOR receiver
H8S71_RS12685	COG2311	Membrane
H8S71_RS12695	COG0454	-acetyltransferase
H8S71_RS12700	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8S71_RS12710	COG0730	response to heat
H8S71_RS12715	COG0425	Belongs to the sulfur carrier protein TusA family
H8S71_RS12720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS12720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_RS12730	COG0425	Belongs to the sulfur carrier protein TusA family
H8S71_RS12730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_RS12735	COG2210	Belongs to the sulfur carrier protein TusA family
H8S71_RS12740	COG1937	Protein conserved in bacteria
H8S71_RS12745	COG0662	Cupin 2, conserved barrel domain protein
H8S71_RS12755	COG4978	Transcriptional regulator
H8S71_RS12755	COG0789	Transcriptional regulator
H8S71_RS12760	COG2814	Major facilitator Superfamily
H8S71_RS12765	COG0456	acetyltransferase
H8S71_RS12770	COG1253	flavin adenine dinucleotide binding
H8S71_RS12780	COG0697	spore germination
H8S71_RS12785	COG0583	DNA-binding transcription factor activity
H8S71_RS12790	COG2072	flavoprotein involved in K transport
H8S71_RS12795	COG1230	cation diffusion facilitator family transporter
H8S71_RS12800	COG1942	4-Oxalocrotonate Tautomerase
H8S71_RS12805	COG0583	DNA-binding transcription factor activity
H8S71_RS12815	COG1114	Component of the transport system for branched-chain amino acids
H8S71_RS12820	COG1687	branched-chain amino acid
H8S71_RS12825	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H8S71_RS12830	COG1522	sequence-specific DNA binding
H8S71_RS12840	COG2124	cytochrome p450
H8S71_RS12855	COG1335	isochorismatase
H8S71_RS12870	COG2318	DinB family
H8S71_RS12880	COG2070	2-Nitropropane dioxygenase
H8S71_RS12885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8S71_RS12895	COG2186	Transcriptional regulator
H8S71_RS12910	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS12915	COG3958	Transketolase
H8S71_RS12920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H8S71_RS12925	COG0477	Major facilitator Superfamily
H8S71_RS12930	COG1846	Transcriptional regulator
H8S71_RS12935	COG3443	Belongs to the bacterial solute-binding protein 9 family
H8S71_RS12940	COG1595	DNA-templated transcription, initiation
H8S71_RS12945	COG0667	Aldo Keto reductase
H8S71_RS12950	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS12955	COG5566	PFAM Mor transcription activator
H8S71_RS12960	COG0596	Alpha beta hydrolase
H8S71_RS12965	COG4991	sh3 domain protein
H8S71_RS12970	COG4991	sh3 domain protein
H8S71_RS12980	COG0346	lactoylglutathione lyase activity
H8S71_RS12990	COG5577	PFAM Coat F domain
H8S71_RS12995	COG1063	alcohol dehydrogenase
H8S71_RS13005	COG5577	PFAM Coat F domain
H8S71_RS13010	COG0789	Transcriptional regulator
H8S71_RS13020	COG1064	alcohol dehydrogenase
H8S71_RS13025	COG0693	protein deglycase activity
H8S71_RS13030	COG1621	beta-fructofuranosidase activity
H8S71_RS13035	COG3716	PTS system mannose fructose sorbose family IID component
H8S71_RS13040	COG3715	PTS system
H8S71_RS13045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS13050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS13055	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H8S71_RS13055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H8S71_RS13065	COG1113	amino acid transport
H8S71_RS13070	COG1280	lysine exporter protein (LysE YggA)
H8S71_RS13075	COG1378	Sugar-specific transcriptional regulator TrmB
H8S71_RS13080	COG1595	DNA-templated transcription, initiation
H8S71_RS13090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H8S71_RS13090	COG2755	lipolytic protein G-D-S-L family
H8S71_RS13100	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_RS13100	COG2124	cytochrome p450
H8S71_RS13105	COG1309	transcriptional regulator
H8S71_RS13110	COG2226	methyltransferase
H8S71_RS13125	COG2116	formate transmembrane transporter activity
H8S71_RS13130	COG5609	conserved protein (DUF2294)
H8S71_RS13135	COG3383	formate dehydrogenase (NAD+) activity
H8S71_RS13140	COG2427	Protein of unknown function (DUF1641)
H8S71_RS13150	COG0626	cystathionine gamma-synthase activity
H8S71_RS13155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_RS13160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H8S71_RS13165	COG2226	methyltransferase
H8S71_RS13180	COG0768	penicillin binding
H8S71_RS13185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H8S71_RS13190	COG0572	uridine kinase
H8S71_RS13195	COG0826	peptidase U32
H8S71_RS13200	COG0826	peptidase U32
H8S71_RS13205	COG4122	O-methyltransferase activity
H8S71_RS13210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H8S71_RS13215	COG3906	Belongs to the UPF0473 family
H8S71_RS13220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H8S71_RS13225	COG4472	Bacterial protein of unknown function (DUF965)
H8S71_RS13230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H8S71_RS13235	COG0628	permease
H8S71_RS13240	COG1126	abc transporter atp-binding protein
H8S71_RS13245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS13250	COG0765	amino acid transport
H8S71_RS13255	COG0765	amino acid transport
H8S71_RS13270	COG3881	PFAM PRC-barrel domain
H8S71_RS13275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H8S71_RS13280	COG0457	Tetratricopeptide repeat
H8S71_RS13285	COG0482	sulfurtransferase activity
H8S71_RS13290	COG1104	cysteine desulfurase activity
H8S71_RS13295	COG1959	2 iron, 2 sulfur cluster binding
H8S71_RS13300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H8S71_RS13305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H8S71_RS13315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H8S71_RS13320	COG0124	histidyl-tRNA synthetase
H8S71_RS13330	COG4991	sh3 domain protein
H8S71_RS13330	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS13330	COG3103	Sh3 type 3 domain protein
H8S71_RS13335	COG1490	D-aminoacyl-tRNA deacylase activity
H8S71_RS13340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H8S71_RS13345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H8S71_RS13350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H8S71_RS13350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H8S71_RS13355	COG5416	Lipopolysaccharide assembly protein A domain
H8S71_RS13360	COG0490	domain, Protein
H8S71_RS13365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8S71_RS13365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H8S71_RS13375	COG2244	polysaccharide biosynthetic process
H8S71_RS13380	COG2323	membrane
H8S71_RS13390	COG1862	Preprotein translocase
H8S71_RS13395	COG0343	queuine tRNA-ribosyltransferase activity
H8S71_RS13400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H8S71_RS13410	COG2255	four-way junction helicase activity
H8S71_RS13415	COG0632	four-way junction helicase activity
H8S71_RS13425	COG2814	Major facilitator Superfamily
H8S71_RS13430	COG0673	inositol 2-dehydrogenase activity
H8S71_RS13435	COG2112	serine threonine protein kinase
H8S71_RS13455	COG1115	amino acid carrier protein
H8S71_RS13460	COG0217	transcriptional regulatory protein
H8S71_RS13470	COG1388	LysM domain
H8S71_RS13475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H8S71_RS13480	COG0157	Belongs to the NadC ModD family
H8S71_RS13485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H8S71_RS13490	COG1104	cysteine desulfurase activity
H8S71_RS13495	COG1827	regulation of RNA biosynthetic process
H8S71_RS13500	COG0077	Prephenate dehydratase
H8S71_RS13505	COG4492	Belongs to the UPF0735 family
H8S71_RS13510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H8S71_RS13515	COG3290	protein histidine kinase activity
H8S71_RS13525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H8S71_RS13530	COG2868	ribosomal protein
H8S71_RS13535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H8S71_RS13540	COG1994	Peptidase M50
H8S71_RS13545	COG0739	heme binding
H8S71_RS13550	COG2894	cell division
H8S71_RS13555	COG0850	regulation of cytokinetic process
H8S71_RS13560	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H8S71_RS13570	COG1077	Cell shape determining protein MreB Mrl
H8S71_RS13575	COG2003	Belongs to the UPF0758 family
H8S71_RS13580	COG0424	maF-like protein
H8S71_RS13590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H8S71_RS13595	COG0285	dihydrofolate synthase activity
H8S71_RS13600	COG0525	valine-tRNA ligase activity
H8S71_RS13610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_RS13615	COG1388	LysM domain
H8S71_RS13620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H8S71_RS13625	COG0113	porphobilinogen synthase activity
H8S71_RS13630	COG1587	Uroporphyrinogen-III synthase
H8S71_RS13635	COG0181	hydroxymethylbilane synthase activity
H8S71_RS13640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H8S71_RS13645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H8S71_RS13655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H8S71_RS13660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H8S71_RS13665	COG1067	ATP-dependent peptidase activity
H8S71_RS13665	COG0470	DNA polymerase III
H8S71_RS13670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H8S71_RS13675	COG0544	peptidyl-prolyl cis-trans isomerase activity
H8S71_RS13680	COG1477	protein flavinylation
H8S71_RS13680	COG0457	Tetratricopeptide repeat
H8S71_RS13685	COG0066	3-isopropylmalate dehydratase activity
H8S71_RS13690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H8S71_RS13695	COG0473	3-isopropylmalate dehydrogenase activity
H8S71_RS13700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H8S71_RS13705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H8S71_RS13710	COG0440	acetolactate synthase activity
H8S71_RS13715	COG0028	Belongs to the TPP enzyme family
H8S71_RS13725	COG0454	-acetyltransferase
H8S71_RS13735	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
H8S71_RS13765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H8S71_RS13785	COG0622	Phosphoesterase
H8S71_RS13790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H8S71_RS13795	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H8S71_RS13800	COG5401	PFAM Sporulation and spore germination
H8S71_RS13805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H8S71_RS13810	COG1846	Transcriptional regulator
H8S71_RS13815	COG2197	response regulator
H8S71_RS13820	COG0824	Thioesterase
H8S71_RS13825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H8S71_RS13830	COG1053	succinate dehydrogenase
H8S71_RS13835	COG2009	succinate dehydrogenase
H8S71_RS13840	COG1719	4-vinyl reductase, 4VR
H8S71_RS13845	COG0527	aspartate kinase activity
H8S71_RS13850	COG0322	excinuclease ABC activity
H8S71_RS13855	COG3118	belongs to the thioredoxin family
H8S71_RS13865	COG3534	alpha-L-arabinofuranosidase
H8S71_RS13870	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H8S71_RS13875	COG2086	electron transfer activity
H8S71_RS13880	COG1024	Enoyl-CoA hydratase
H8S71_RS13885	COG1309	transcriptional regulator
H8S71_RS13890	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS13895	COG3766	membrane
H8S71_RS13900	COG1193	negative regulation of DNA recombination
H8S71_RS13905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H8S71_RS13905	COG1796	DNA polymerase
H8S71_RS13910	COG1286	toxin biosynthetic process
H8S71_RS13915	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H8S71_RS13920	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H8S71_RS13925	COG0072	phenylalanine-tRNA ligase activity
H8S71_RS13925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_RS13930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H8S71_RS13940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H8S71_RS13950	COG3835	regulator
H8S71_RS13955	COG0277	FAD linked oxidase domain protein
H8S71_RS13960	COG0247	lactate metabolic process
H8S71_RS13965	COG0346	lactoylglutathione lyase activity
H8S71_RS13970	COG1966	Carbon starvation protein
H8S71_RS13975	COG3534	alpha-L-arabinofuranosidase
H8S71_RS13980	COG0395	ABC-type sugar transport system, permease component
H8S71_RS13985	COG1175	transmembrane transport
H8S71_RS13990	COG1653	transport
H8S71_RS13995	COG0371	Dehydrogenase
H8S71_RS14000	COG0647	UMP catabolic process
H8S71_RS14005	COG0235	Class ii aldolase
H8S71_RS14010	COG1069	ribulokinase activity
H8S71_RS14015	COG2160	L-arabinose isomerase activity
H8S71_RS14020	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_RS14025	COG1363	Peptidase, m42
H8S71_RS14035	COG3326	Membrane
H8S71_RS14040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H8S71_RS14045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H8S71_RS14050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H8S71_RS14060	COG1346	cytolysis
H8S71_RS14065	COG1380	Effector of murein hydrolase LrgA
H8S71_RS14070	COG3279	Response regulator of the LytR AlgR family
H8S71_RS14075	COG3275	phosphorelay sensor kinase activity
H8S71_RS14080	COG1011	Hydrolase
H8S71_RS14085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8S71_RS14095	COG0398	Pfam SNARE associated Golgi protein
H8S71_RS14100	COG1484	DNA-dependent DNA replication
H8S71_RS14105	COG3611	Membrane attachment protein
H8S71_RS14110	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H8S71_RS14115	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H8S71_RS14120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8S71_RS14125	COG1733	regulation of RNA biosynthetic process
H8S71_RS14130	COG2814	Major facilitator Superfamily
H8S71_RS14135	COG0656	L-ascorbic acid biosynthetic process
H8S71_RS14140	COG0237	dephospho-CoA kinase activity
H8S71_RS14145	COG1971	Probably functions as a manganese efflux pump
H8S71_RS14150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H8S71_RS14155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_RS14155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H8S71_RS14160	COG5002	protein histidine kinase activity
H8S71_RS14165	COG0745	RESPONSE REGULATOR receiver
H8S71_RS14170	COG0039	L-malate dehydrogenase activity
H8S71_RS14175	COG0538	isocitrate dehydrogenase activity
H8S71_RS14180	COG0372	Belongs to the citrate synthase family
H8S71_RS14185	COG2707	UPF0756 membrane protein
H8S71_RS14190	COG0628	permease
H8S71_RS14195	COG3030	protein affecting phage T7 exclusion by the F plasmid
H8S71_RS14200	COG0469	pyruvate kinase activity
H8S71_RS14205	COG0205	6-phosphofructokinase activity
H8S71_RS14210	COG0825	malonyl-CoA metabolic process
H8S71_RS14215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H8S71_RS14220	COG0281	malic enzyme
H8S71_RS14225	COG0587	DNA-directed DNA polymerase activity
H8S71_RS14245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H8S71_RS14255	COG4109	DRTGG domain
H8S71_RS14260	COG0730	response to heat
H8S71_RS14265	COG1473	amidohydrolase
H8S71_RS14270	COG0196	riboflavin kinase activity
H8S71_RS14275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS14280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H8S71_RS14285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS14290	COG1126	abc transporter atp-binding protein
H8S71_RS14295	COG0765	amino acid transport
H8S71_RS14300	COG0765	amino acid transport
H8S71_RS14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS14315	COG0454	-acetyltransferase
H8S71_RS14320	COG0583	DNA-binding transcription factor activity
H8S71_RS14325	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H8S71_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS14335	COG0165	Argininosuccinate lyase
H8S71_RS14340	COG0137	argininosuccinate synthase activity
H8S71_RS14345	COG0521	Mo-molybdopterin cofactor biosynthetic process
H8S71_RS14350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H8S71_RS14360	COG0827	DNA restriction-modification system
H8S71_RS14365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H8S71_RS14370	COG3874	Sporulation protein YtfJ
H8S71_RS14380	COG1714	RDD family
H8S71_RS14385	COG0616	signal peptide processing
H8S71_RS14390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H8S71_RS14395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H8S71_RS14400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8S71_RS14410	COG0301	tRNA thio-modification
H8S71_RS14415	COG1104	cysteine desulfurase activity
H8S71_RS14420	COG1114	Component of the transport system for branched-chain amino acids
H8S71_RS14425	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H8S71_RS14430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H8S71_RS14435	COG1309	transcriptional regulator
H8S71_RS14440	COG1956	GAF domain-containing protein
H8S71_RS14445	COG2199	diguanylate cyclase activity
H8S71_RS14445	COG2203	Gaf domain
H8S71_RS14450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H8S71_RS14455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8S71_RS14460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H8S71_RS14465	COG0454	-acetyltransferase
H8S71_RS14470	COG0517	IMP dehydrogenase activity
H8S71_RS14475	COG0123	including yeast histone deacetylase and acetoin utilization protein
H8S71_RS14480	COG1360	Flagellar Motor Protein
H8S71_RS14485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H8S71_RS14490	COG1609	Transcriptional regulator
H8S71_RS14495	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H8S71_RS14495	COG1605	Chorismate mutase
H8S71_RS14500	COG3118	belongs to the thioredoxin family
H8S71_RS14505	COG4980	gas vesicle protein
H8S71_RS14510	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H8S71_RS14515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H8S71_RS14520	COG1674	ftsk spoiiie
H8S71_RS14525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H8S71_RS14530	COG4848	Belongs to the UPF0354 family
H8S71_RS14535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS14550	COG1363	Peptidase, m42
H8S71_RS14555	COG5584	Small secreted protein
H8S71_RS14560	COG0281	malic enzyme
H8S71_RS14565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS14570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H8S71_RS14580	COG0510	thiamine kinase activity
H8S71_RS14585	COG1523	belongs to the glycosyl hydrolase 13 family
H8S71_RS14590	COG1597	lipid kinase activity
H8S71_RS14600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H8S71_RS14605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H8S71_RS14610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_RS14615	COG2252	PERMEase
H8S71_RS14620	COG4473	ABC transporter
H8S71_RS14625	COG1131	(ABC) transporter
H8S71_RS14630	COG1349	DNA-binding transcription factor activity
H8S71_RS14635	COG1187	pseudouridine synthase activity
H8S71_RS14640	COG2244	polysaccharide biosynthetic process
H8S71_RS14645	COG2081	HI0933 family
H8S71_RS14650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H8S71_RS14660	COG5578	integral membrane protein
H8S71_RS14665	COG0673	inositol 2-dehydrogenase activity
H8S71_RS14670	COG1653	transport
H8S71_RS14675	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H8S71_RS14680	COG4209	transmembrane transport
H8S71_RS14685	COG2207	Transcriptional regulator
H8S71_RS14690	COG1653	transport
H8S71_RS14695	COG0395	ABC-type sugar transport system, permease component
H8S71_RS14700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_RS14705	COG2124	cytochrome p450
H8S71_RS14710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H8S71_RS14720	COG0156	8-amino-7-oxononanoate synthase activity
H8S71_RS14725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H8S71_RS14735	COG1073	alpha beta
H8S71_RS14740	COG1609	Transcriptional regulator
H8S71_RS14745	COG1653	transport
H8S71_RS14750	COG1175	transmembrane transport
H8S71_RS14755	COG0395	ABC-type sugar transport system, permease component
H8S71_RS14760	COG1486	melibiose metabolic process
H8S71_RS14765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H8S71_RS14770	COG0495	leucyl-tRNA aminoacylation
H8S71_RS14780	COG2202	Pas domain
H8S71_RS14780	COG1366	Belongs to the anti-sigma-factor antagonist family
H8S71_RS14785	COG2814	Major facilitator Superfamily
H8S71_RS14790	COG2433	Pfam Transposase IS66
H8S71_RS14795	COG0577	efflux transmembrane transporter activity
H8S71_RS14800	COG1136	(ABC) transporter
H8S71_RS14805	COG2205	protein histidine kinase activity
H8S71_RS14810	COG0745	RESPONSE REGULATOR receiver
H8S71_RS14815	COG0577	efflux transmembrane transporter activity
H8S71_RS14820	COG1136	(ABC) transporter
H8S71_RS14835	COG1131	(ABC) transporter
H8S71_RS14840	COG1725	Transcriptional regulator
H8S71_RS14855	COG1242	4 iron, 4 sulfur cluster binding
H8S71_RS14860	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H8S71_RS14870	COG2267	carboxylic ester hydrolase activity
H8S71_RS14875	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H8S71_RS14880	COG1113	amino acid transport
H8S71_RS14885	COG0367	asparagine synthase
H8S71_RS14890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H8S71_RS14895	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H8S71_RS14905	COG1506	peptidase
H8S71_RS14910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H8S71_RS14915	COG1116	anion transmembrane transporter activity
H8S71_RS14920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H8S71_RS14925	COG0494	nUDIX hydrolase
H8S71_RS14930	COG4824	toxin secretion phage lysis holin
H8S71_RS14935	COG0783	Belongs to the Dps family
H8S71_RS14950	COG1854	S-ribosylhomocysteine lyase activity
H8S71_RS14955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H8S71_RS14960	COG0288	reversible hydration of carbon dioxide
H8S71_RS14965	COG0254	rRNA binding
H8S71_RS14970	COG1271	oxidase subunit
H8S71_RS14975	COG1294	oxidase, subunit
H8S71_RS14985	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_RS14990	COG1321	iron dependent repressor
H8S71_RS14990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H8S71_RS14995	COG1121	(ABC) transporter
H8S71_RS15000	COG0803	Belongs to the bacterial solute-binding protein 9 family
H8S71_RS15005	COG4948	Mandelate Racemase Muconate Lactonizing
H8S71_RS15010	COG0318	PFAM AMP-dependent synthetase and ligase
H8S71_RS15015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H8S71_RS15020	COG0596	Alpha beta hydrolase
H8S71_RS15025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H8S71_RS15030	COG1169	isochorismate synthase
H8S71_RS15035	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H8S71_RS15040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_RS15045	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_RS15050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H8S71_RS15055	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS15065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_RS15070	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS15075	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_RS15080	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
H8S71_RS15085	COG0058	SHG alpha-glucan phosphorylase activity
H8S71_RS15090	COG0297	glycogen (starch) synthase activity
H8S71_RS15095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8S71_RS15100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H8S71_RS15105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H8S71_RS15230	COG3859	Proton-coupled thiamine transporter YuaJ
H8S71_RS15235	COG1247	-acetyltransferase
H8S71_RS15240	COG2268	Band 7 protein
H8S71_RS15245	COG1585	Membrane protein implicated in regulation of membrane protease activity
H8S71_RS15250	COG2318	DinB family
H8S71_RS15260	COG1454	alcohol dehydrogenase
H8S71_RS15265	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS15270	COG1510	regulation of RNA biosynthetic process
H8S71_RS15280	COG0569	domain protein
H8S71_RS15285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H8S71_RS15290	COG4682	membrane
H8S71_RS15295	COG1705	Flagellar rod assembly protein muramidase FlgJ
H8S71_RS15300	COG0477	Major facilitator Superfamily
H8S71_RS15305	COG5553	Cysteine dioxygenase type I
H8S71_RS15315	COG1968	undecaprenyl-diphosphatase activity
H8S71_RS15320	COG0628	permease
H8S71_RS15325	COG0673	inositol 2-dehydrogenase activity
H8S71_RS15330	COG4806	L-rhamnose isomerase
H8S71_RS15335	COG3254	rhamnose metabolic process
H8S71_RS15340	COG1070	Carbohydrate kinase
H8S71_RS15345	COG1349	DNA-binding transcription factor activity
H8S71_RS15350	COG3347	Dehydrogenase
H8S71_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS15355	COG0840	transmembrane signaling receptor activity
H8S71_RS15360	COG0840	transmembrane signaling receptor activity
H8S71_RS15365	COG0840	transmembrane signaling receptor activity
H8S71_RS15370	COG0840	transmembrane signaling receptor activity
H8S71_RS15385	COG0432	Pfam Uncharacterised protein family UPF0047
H8S71_RS15395	COG0366	Alpha amylase catalytic
H8S71_RS15400	COG1253	flavin adenine dinucleotide binding
H8S71_RS15405	COG2738	Putative neutral zinc metallopeptidase
H8S71_RS15420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H8S71_RS15435	COG0166	Belongs to the GPI family
H8S71_RS15440	COG1979	alcohol dehydrogenase
H8S71_RS15445	COG1979	alcohol dehydrogenase
H8S71_RS15450	COG2155	Conserved Protein
H8S71_RS15455	COG1098	S1 RNA binding domain
H8S71_RS15460	COG0436	Aminotransferase
H8S71_RS15465	COG1522	sequence-specific DNA binding
H8S71_RS15470	COG2267	carboxylic ester hydrolase activity
H8S71_RS15480	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H8S71_RS15485	COG2205	protein histidine kinase activity
H8S71_RS15495	COG5018	Exonuclease
H8S71_RS15500	COG2814	Major facilitator Superfamily
H8S71_RS15505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_RS15510	COG3011	Protein conserved in bacteria
H8S71_RS15520	COG3290	protein histidine kinase activity
H8S71_RS15525	COG4565	transcriptional regulatory protein
H8S71_RS15530	COG1744	ABC transporter substrate-binding protein PnrA-like
H8S71_RS15535	COG3845	ABC transporter
H8S71_RS15540	COG4603	Belongs to the binding-protein-dependent transport system permease family
H8S71_RS15545	COG1079	Belongs to the binding-protein-dependent transport system permease family
H8S71_RS15550	COG3493	citrate carrier protein
H8S71_RS15560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H8S71_RS15560	COG2111	Na H antiporter
H8S71_RS15565	COG2111	Na H antiporter
H8S71_RS15570	COG1006	Multisubunit Na H antiporter MnhC subunit
H8S71_RS15575	COG0651	ATP synthesis coupled electron transport
H8S71_RS15580	COG1863	multisubunit Na H antiporter MnhE subunit
H8S71_RS15585	COG2212	antiporter activity
H8S71_RS15590	COG1320	monovalent cation:proton antiporter activity
H8S71_RS15595	COG2050	protein possibly involved in aromatic compounds catabolism
H8S71_RS15600	COG2197	response regulator
H8S71_RS15605	COG4585	Histidine kinase
H8S71_RS15615	COG0142	geranyltranstransferase activity
H8S71_RS15630	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H8S71_RS15635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H8S71_RS15640	COG1335	isochorismatase
H8S71_RS15645	COG5506	Protein of unknown function (DUF1694)
H8S71_RS15660	COG0628	permease
H8S71_RS15675	COG1418	mRNA catabolic process
H8S71_RS15680	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS15690	COG1511	domain protein
H8S71_RS15695	COG1674	ftsk spoiiie
H8S71_RS15695	COG0433	COG0433 Predicted ATPase
H8S71_RS15700	COG4499	WXG100 protein secretion system (Wss), protein YukC
H8S71_RS15705	COG5417	Belongs to the EsaB family
H8S71_RS15710	COG4842	Belongs to the WXG100 family
H8S71_RS15715	COG2508	Transcriptional regulator
H8S71_RS15715	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H8S71_RS15720	COG0686	Belongs to the AlaDH PNT family
H8S71_RS15725	COG5634	Uncharacterized conserved protein (DUF2278)
H8S71_RS15730	COG3251	PFAM MbtH domain protein
H8S71_RS15735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS15740	COG3433	isochorismatase activity
H8S71_RS15740	COG1535	isochorismatase
H8S71_RS15745	COG1021	2,3-dihydroxybenzoate-AMP ligase
H8S71_RS15750	COG1169	isochorismate synthase
H8S71_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS15760	COG2819	hydrolase of the alpha beta superfamily
H8S71_RS15765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H8S71_RS15770	COG1268	BioY protein
H8S71_RS15775	COG2056	Na+-H+ antiporter family
H8S71_RS15780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H8S71_RS15785	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H8S71_RS15790	COG3584	3D domain protein
H8S71_RS15805	COG1252	NADH dehydrogenase
H8S71_RS15810	COG0492	ferredoxin-NADP+ reductase activity
H8S71_RS15820	COG0516	GMP reductase activity
H8S71_RS15825	COG2808	Putative FMN-binding domain
H8S71_RS15830	COG0456	acetyltransferase
H8S71_RS15835	COG0316	Belongs to the HesB IscA family
H8S71_RS15840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H8S71_RS15845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_RS15850	COG4844	belongs to the
H8S71_RS15855	COG1252	NADH dehydrogenase
H8S71_RS15860	COG4837	Protein of unknown function (DUF1462)
H8S71_RS15865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H8S71_RS15870	COG4946	Tricorn protease homolog
H8S71_RS15870	COG1506	peptidase
H8S71_RS15870	COG0823	Involved in the tonB-independent uptake of proteins
H8S71_RS15875	COG0083	homoserine kinase activity
H8S71_RS15880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H8S71_RS15885	COG0460	homoserine dehydrogenase
H8S71_RS15890	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H8S71_RS15895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H8S71_RS15900	COG0647	UMP catabolic process
H8S71_RS15905	COG2445	Protein of unknown function DUF86
H8S71_RS15910	COG4470	Protein conserved in bacteria
H8S71_RS15920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H8S71_RS15925	COG0739	heme binding
H8S71_RS15935	COG3377	Domain of unknown function (DUF1805)
H8S71_RS15940	COG0737	Belongs to the 5'-nucleotidase family
H8S71_RS15945	COG0730	response to heat
H8S71_RS15950	COG1801	Protein of unknown function DUF72
H8S71_RS15960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H8S71_RS15965	COG2508	Transcriptional regulator
H8S71_RS15970	COG2233	PERMEase
H8S71_RS15975	COG2233	PERMEase
H8S71_RS15980	COG3648	Uricase
H8S71_RS15980	COG3195	allantoin biosynthetic process
H8S71_RS15985	COG2351	hydroxyisourate hydrolase activity
H8S71_RS15995	COG2080	2 iron, 2 sulfur cluster binding
H8S71_RS16000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H8S71_RS16005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H8S71_RS16010	COG2068	MobA-Related Protein
H8S71_RS16015	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H8S71_RS16020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H8S71_RS16025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H8S71_RS16035	COG2356	endonuclease I
H8S71_RS16040	COG3842	ATPase activity
H8S71_RS16045	COG2188	Transcriptional regulator
H8S71_RS16050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_RS16055	COG0395	ABC-type sugar transport system, permease component
H8S71_RS16060	COG1175	transmembrane transport
H8S71_RS16065	COG1653	transport
H8S71_RS16070	COG2222	sugar isomerase
H8S71_RS16075	COG0322	excinuclease ABC activity
H8S71_RS16080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H8S71_RS16095	COG0346	lactoylglutathione lyase activity
H8S71_RS16100	COG0640	Transcriptional regulator
H8S71_RS16105	COG0719	Fe-S assembly protein
H8S71_RS16110	COG0822	iron-sulfur transferase activity
H8S71_RS16115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H8S71_RS16120	COG0719	Fe-S assembly protein
H8S71_RS16125	COG0396	ATPase activity
H8S71_RS16135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H8S71_RS16140	COG1464	Belongs to the NlpA lipoprotein family
H8S71_RS16145	COG2011	ABC-type metal ion transport system permease component
H8S71_RS16150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H8S71_RS16160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H8S71_RS16165	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H8S71_RS16175	COG0509	glycine decarboxylation via glycine cleavage system
H8S71_RS16180	COG1393	Belongs to the ArsC family
H8S71_RS16185	COG1960	acyl-CoA dehydrogenase activity
H8S71_RS16190	COG0183	Belongs to the thiolase family
H8S71_RS16195	COG1024	Enoyl-CoA hydratase
H8S71_RS16195	COG1250	3-hydroxyacyl-CoA dehydrogenase
H8S71_RS16205	COG0506	proline dehydrogenase activity
H8S71_RS16215	COG5577	PFAM Coat F domain
H8S71_RS16220	COG1846	Transcriptional regulator
H8S71_RS16225	COG0477	Major facilitator Superfamily
H8S71_RS16230	COG1942	4-Oxalocrotonate Tautomerase
H8S71_RS16235	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS16240	COG0583	DNA-binding transcription factor activity
H8S71_RS16250	COG1120	ATPase activity
H8S71_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS16270	COG0783	Belongs to the Dps family
H8S71_RS16275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_RS16280	COG0745	RESPONSE REGULATOR receiver
H8S71_RS16285	COG2770	Histidine kinase
H8S71_RS16285	COG2205	protein histidine kinase activity
H8S71_RS16295	COG1309	transcriptional regulator
H8S71_RS16300	COG0114	fumarate hydratase activity
H8S71_RS16310	COG0697	spore germination
H8S71_RS16315	COG0814	amino acid
H8S71_RS16325	COG2197	response regulator
H8S71_RS16330	COG4585	Histidine kinase
H8S71_RS16335	COG4758	membrane
H8S71_RS16340	COG3595	metallopeptidase activity
H8S71_RS16345	COG1842	Phage shock protein A
H8S71_RS16350	COG4758	membrane
H8S71_RS16355	COG2814	Major facilitator Superfamily
H8S71_RS16360	COG2096	Adenosyltransferase
H8S71_RS16365	COG1120	ATPase activity
H8S71_RS16370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS16375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS16380	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS16385	COG3386	PFAM SMP-30 Gluconolaconase
H8S71_RS16390	COG2205	protein histidine kinase activity
H8S71_RS16395	COG0745	RESPONSE REGULATOR receiver
H8S71_RS16405	COG1191	sigma factor activity
H8S71_RS16415	COG2140	Oxalate decarboxylase
H8S71_RS16425	COG0577	efflux transmembrane transporter activity
H8S71_RS16430	COG1136	(ABC) transporter
H8S71_RS16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H8S71_RS16440	COG1120	ATPase activity
H8S71_RS16445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS16450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H8S71_RS16455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS16460	COG0531	amino acid
H8S71_RS16470	COG1988	membrane-bound metal-dependent
H8S71_RS16475	COG1368	sulfuric ester hydrolase activity
H8S71_RS16480	COG1910	domain protein
H8S71_RS16485	COG0725	ABC transporter, periplasmic molybdate-binding protein
H8S71_RS16490	COG4149	molybdate abc transporter
H8S71_RS16495	COG0656	L-ascorbic acid biosynthetic process
H8S71_RS16505	COG0025	NhaP-type Na H and K H
H8S71_RS16510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H8S71_RS16515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H8S71_RS16520	COG3973	AAA domain
H8S71_RS16530	COG2860	membrane
H8S71_RS16535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H8S71_RS16540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H8S71_RS16545	COG2217	Heavy metal translocating P-type atpase
H8S71_RS16550	COG2217	Heavy metal translocating P-type atpase
H8S71_RS16555	COG2608	mercury ion transmembrane transporter activity
H8S71_RS16560	COG1937	Protein conserved in bacteria
H8S71_RS16565	COG0673	inositol 2-dehydrogenase activity
H8S71_RS16570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H8S71_RS16575	COG1289	transmembrane transporter activity
H8S71_RS16585	COG2076	Multidrug Resistance protein
H8S71_RS16590	COG1309	transcriptional regulator
H8S71_RS16595	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS16605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H8S71_RS16610	COG0557	exoribonuclease II activity
H8S71_RS16615	COG1647	Serine aminopeptidase, S33
H8S71_RS16620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H8S71_RS16625	COG0596	Alpha beta hydrolase
H8S71_RS16630	COG1476	TRANSCRIPTIONal
H8S71_RS16635	COG1396	sequence-specific DNA binding
H8S71_RS16640	COG1396	sequence-specific DNA binding
H8S71_RS16645	COG1733	regulation of RNA biosynthetic process
H8S71_RS16650	COG0840	transmembrane signaling receptor activity
H8S71_RS16655	COG1174	glycine betaine transport
H8S71_RS16660	COG1732	Glycine betaine
H8S71_RS16665	COG1174	glycine betaine transport
H8S71_RS16670	COG0517	IMP dehydrogenase activity
H8S71_RS16670	COG1125	glycine betaine transport
H8S71_RS16675	COG1510	regulation of RNA biosynthetic process
H8S71_RS16680	COG1174	glycine betaine transport
H8S71_RS16685	COG1732	Glycine betaine
H8S71_RS16690	COG1174	glycine betaine transport
H8S71_RS16695	COG1125	glycine betaine transport
H8S71_RS16695	COG0517	IMP dehydrogenase activity
H8S71_RS16700	COG1510	regulation of RNA biosynthetic process
H8S71_RS16705	COG2095	MarC family integral membrane protein
H8S71_RS16715	COG3064	Membrane
H8S71_RS16720	COG4640	response to antibiotic
H8S71_RS16725	COG0456	acetyltransferase
H8S71_RS16730	COG0148	phosphopyruvate hydratase activity
H8S71_RS16735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H8S71_RS16740	COG0149	triose-phosphate isomerase activity
H8S71_RS16745	COG0126	phosphoglycerate kinase activity
H8S71_RS16750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H8S71_RS16755	COG2390	Transcriptional regulator
H8S71_RS16760	COG2814	Major facilitator Superfamily
H8S71_RS16765	COG1609	Transcriptional regulator
H8S71_RS16770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS16775	COG0583	DNA-binding transcription factor activity
H8S71_RS16780	COG0697	spore germination
H8S71_RS16785	COG1113	amino acid transport
H8S71_RS16790	COG3858	chitin binding
H8S71_RS16795	COG1556	Lactate utilization protein
H8S71_RS16800	COG1139	Iron-sulfur cluster binding protein
H8S71_RS16805	COG0247	lactate metabolic process
H8S71_RS16810	COG2197	response regulator
H8S71_RS16815	COG4585	Histidine kinase
H8S71_RS16820	COG0842	Transport permease protein
H8S71_RS16825	COG1131	(ABC) transporter
H8S71_RS16830	COG0596	Alpha beta hydrolase
H8S71_RS16835	COG2208	phosphoserine phosphatase activity
H8S71_RS16840	COG3867	Arabinogalactan endo-beta-1,4-galactanase
H8S71_RS16845	COG1874	Beta-galactosidase
H8S71_RS16850	COG3833	ABC-type maltose transport systems, permease component
H8S71_RS16855	COG1175	transmembrane transport
H8S71_RS16860	COG2182	Extracellular solute-binding protein
H8S71_RS16865	COG1609	Transcriptional regulator
H8S71_RS16870	COG2186	Transcriptional regulator
H8S71_RS16875	COG1620	l-lactate permease
H8S71_RS16880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H8S71_RS16890	COG5039	Polysaccharide pyruvyl transferase
H8S71_RS16895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_RS16900	COG0110	maltose O-acetyltransferase activity
H8S71_RS16905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H8S71_RS16910	COG2244	polysaccharide biosynthetic process
H8S71_RS16915	COG1216	Glycosyl transferase, family 2
H8S71_RS16920	COG5039	Polysaccharide pyruvyl transferase
H8S71_RS16925	COG1216	Glycosyl transferase, family 2
H8S71_RS16935	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS16940	COG1215	transferase activity, transferring glycosyl groups
H8S71_RS16945	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS16950	COG1086	Polysaccharide biosynthesis protein
H8S71_RS16955	COG0489	protein tyrosine kinase activity
H8S71_RS16960	COG3944	biosynthesis protein
H8S71_RS16965	COG1396	sequence-specific DNA binding
H8S71_RS16970	COG2272	Belongs to the type-B carboxylesterase lipase family
H8S71_RS16980	COG3479	Phenolic acid decarboxylase
H8S71_RS16990	COG1794	racemase activity, acting on amino acids and derivatives
H8S71_RS16995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H8S71_RS17005	COG1621	beta-fructofuranosidase activity
H8S71_RS17010	COG1621	beta-fructofuranosidase activity
H8S71_RS17015	COG0531	amino acid
H8S71_RS17020	COG1309	transcriptional regulator
H8S71_RS17025	COG2076	Multidrug Resistance protein
H8S71_RS17030	COG2076	Multidrug Resistance protein
H8S71_RS17045	COG0740	serine-type endopeptidase activity
H8S71_RS17050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H8S71_RS17055	COG0366	Alpha amylase catalytic
H8S71_RS17060	COG1554	hydrolase, family 65, central catalytic
H8S71_RS17065	COG5521	maltodextrose utilization protein MalA
H8S71_RS17070	COG3833	ABC-type maltose transport systems, permease component
H8S71_RS17075	COG1175	transmembrane transport
H8S71_RS17080	COG2182	Extracellular solute-binding protein
H8S71_RS17085	COG0366	Alpha amylase catalytic
H8S71_RS17090	COG1609	Transcriptional regulator
H8S71_RS17095	COG1611	Belongs to the LOG family
H8S71_RS17100	COG1694	Mazg nucleotide pyrophosphohydrolase
H8S71_RS17105	COG0659	secondary active sulfate transmembrane transporter activity
H8S71_RS17110	COG0288	reversible hydration of carbon dioxide
H8S71_RS17115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H8S71_RS17120	COG0577	efflux transmembrane transporter activity
H8S71_RS17125	COG1136	(ABC) transporter
H8S71_RS17130	COG5002	protein histidine kinase activity
H8S71_RS17135	COG0745	RESPONSE REGULATOR receiver
H8S71_RS17145	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H8S71_RS17150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS17155	COG1481	regulation of sporulation
H8S71_RS17160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H8S71_RS17165	COG1660	Displays ATPase and GTPase activities
H8S71_RS17170	COG1051	belongs to the nudix hydrolase family
H8S71_RS17175	COG0492	ferredoxin-NADP+ reductase activity
H8S71_RS17180	COG0791	NLP P60 protein
H8S71_RS17180	COG3883	PFAM NLP P60 protein
H8S71_RS17185	COG0457	Tetratricopeptide repeat
H8S71_RS17190	COG1132	(ABC) transporter
H8S71_RS17225	COG0140	phosphoribosyl-ATP diphosphatase activity
H8S71_RS17225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H8S71_RS17230	COG0107	imidazoleglycerol-phosphate synthase activity
H8S71_RS17235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H8S71_RS17240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H8S71_RS17245	COG0131	Imidazoleglycerol-phosphate dehydratase
H8S71_RS17250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H8S71_RS17255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H8S71_RS17260	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H8S71_RS17265	COG4990	cell redox homeostasis
H8S71_RS17270	COG5297	Belongs to the glycosyl hydrolase family 6
H8S71_RS17275	COG0110	maltose O-acetyltransferase activity
H8S71_RS17280	COG0546	phosphoglycolate phosphatase activity
H8S71_RS17285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H8S71_RS17290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H8S71_RS17295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H8S71_RS17300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H8S71_RS17305	COG0363	glucosamine-6-phosphate deaminase activity
H8S71_RS17310	COG2188	Transcriptional regulator
H8S71_RS17315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H8S71_RS17320	COG1950	PFAM Membrane protein of
H8S71_RS17325	COG1983	PspC domain protein
H8S71_RS17330	COG3595	metallopeptidase activity
H8S71_RS17345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_RS17350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H8S71_RS17355	COG0556	nucleotide-excision repair
H8S71_RS17360	COG4897	Protein conserved in bacteria
H8S71_RS17365	COG3848	Pyruvate phosphate dikinase
H8S71_RS17365	COG0574	Belongs to the PEP-utilizing enzyme family
H8S71_RS17370	COG1309	transcriptional regulator
H8S71_RS17375	COG2814	Major facilitator Superfamily
H8S71_RS17380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_RS17390	COG3409	Peptidoglycan-binding domain 1 protein
H8S71_RS17390	COG0793	Belongs to the peptidase S41A family
H8S71_RS17395	COG2177	Part of the ABC transporter FtsEX involved in
H8S71_RS17400	COG2884	Cell division ATP-binding protein ftsE
H8S71_RS17405	COG2010	Cytochrome c
H8S71_RS17410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS17420	COG0653	protein targeting
H8S71_RS17425	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H8S71_RS17440	COG1516	flagellar protein fliS
H8S71_RS17445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H8S71_RS17450	COG1334	flagellar protein FlaG
H8S71_RS17455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_RS17460	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H8S71_RS17465	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H8S71_RS17475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H8S71_RS17480	COG1256	bacterial-type flagellum assembly
H8S71_RS17480	COG4786	Flagellar basal body rod
H8S71_RS17485	COG3418	PFAM FlgN family protein
H8S71_RS17490	COG2747	anti-sigma28 factor FlgM
H8S71_RS17500	COG1040	competence protein
H8S71_RS17510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H8S71_RS17515	COG1307	EDD domain protein, DegV family
H8S71_RS17520	COG2197	response regulator
H8S71_RS17525	COG4585	Histidine kinase
H8S71_RS17530	COG1739	Uncharacterized protein family UPF0029
H8S71_RS17535	COG1316	TRANSCRIPTIONal
H8S71_RS17540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H8S71_RS17545	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS17550	COG1215	transferase activity, transferring glycosyl groups
H8S71_RS17555	COG3206	protein involved in exopolysaccharide biosynthesis
H8S71_RS17560	COG3307	-O-antigen
H8S71_RS17565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_RS17570	COG0297	glycogen (starch) synthase activity
H8S71_RS17570	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS17575	COG2244	polysaccharide biosynthetic process
H8S71_RS17585	COG0860	N-Acetylmuramoyl-L-alanine amidase
H8S71_RS17585	COG2247	cell wall binding repeat
H8S71_RS17590	COG2247	cell wall binding repeat
H8S71_RS17590	COG2385	sporulation resulting in formation of a cellular spore
H8S71_RS17600	COG1316	TRANSCRIPTIONal
H8S71_RS17605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H8S71_RS17610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H8S71_RS17615	COG1134	teichoic acid transport
H8S71_RS17620	COG1682	transport, permease protein
H8S71_RS17625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_RS17630	COG0438	transferase activity, transferring glycosyl groups
H8S71_RS17635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H8S71_RS17640	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H8S71_RS17645	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_RS17655	COG4193	domain, Protein
H8S71_RS17660	COG1482	cell wall glycoprotein biosynthetic process
H8S71_RS17665	COG0697	spore germination
H8S71_RS17670	COG0814	amino acid
H8S71_RS17680	COG2814	Major facilitator Superfamily
H8S71_RS17685	COG1316	TRANSCRIPTIONal
H8S71_RS17690	COG0561	phosphatase activity
H8S71_RS17695	COG0791	NLP P60 protein
H8S71_RS17705	COG2843	Capsule synthesis protein
H8S71_RS17715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H8S71_RS17720	COG1609	Transcriptional regulator
H8S71_RS17725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_RS17730	COG1869	D-ribose catabolic process
H8S71_RS17735	COG1129	ABC transporter
H8S71_RS17740	COG1172	Belongs to the binding-protein-dependent transport system permease family
H8S71_RS17745	COG1879	ABC-type sugar transport system periplasmic component
H8S71_RS17750	COG3103	Sh3 type 3 domain protein
H8S71_RS17760	COG2249	NAD(P)H dehydrogenase (quinone) activity
H8S71_RS17765	COG3527	Alpha-acetolactate decarboxylase
H8S71_RS17770	COG0028	Belongs to the TPP enzyme family
H8S71_RS17775	COG0583	DNA-binding transcription factor activity
H8S71_RS17780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H8S71_RS17795	COG5337	Spore coat protein CotH
H8S71_RS17805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H8S71_RS17815	COG0405	Gamma-glutamyltransferase
H8S71_RS17820	COG1522	sequence-specific DNA binding
H8S71_RS17825	COG2059	Chromate
H8S71_RS17830	COG2059	Chromate
H8S71_RS17840	COG0655	NAD(P)H dehydrogenase (quinone) activity
H8S71_RS17845	COG0583	DNA-binding transcription factor activity
H8S71_RS17865	COG5444	nuclease activity
H8S71_RS17885	COG3878	Protein conserved in bacteria
H8S71_RS17890	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H8S71_RS17895	COG4464	protein tyrosine phosphatase activity
H8S71_RS17900	COG0489	protein tyrosine kinase activity
H8S71_RS17905	COG3944	biosynthesis protein
H8S71_RS17915	COG4715	Zinc finger, swim domain protein
H8S71_RS17920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H8S71_RS17925	COG0561	phosphatase activity
H8S71_RS17930	COG1349	DNA-binding transcription factor activity
H8S71_RS17935	COG0629	single-stranded DNA binding
H8S71_RS17950	COG3764	Sortase (surface protein transpeptidase)
H8S71_RS17960	COG3279	Response regulator of the LytR AlgR family
H8S71_RS17965	COG0745	RESPONSE REGULATOR receiver
H8S71_RS17965	COG2972	Histidine kinase
H8S71_RS17970	COG1970	mechanosensitive ion channel activity
H8S71_RS17975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H8S71_RS17980	COG0457	Tetratricopeptide repeat
H8S71_RS17985	COG4786	Flagellar basal body rod
H8S71_RS17990	COG4786	Flagellar basal body rod
H8S71_RS17995	COG1077	Cell shape determining protein MreB Mrl
H8S71_RS18000	COG1609	Transcriptional regulator
H8S71_RS18010	COG1846	Transcriptional regulator
H8S71_RS18015	COG2814	Major facilitator Superfamily
H8S71_RS18020	COG3420	alginic acid biosynthetic process
H8S71_RS18025	COG1953	Uracil, thiamine, allantoin
H8S71_RS18030	COG0477	Major facilitator Superfamily
H8S71_RS18035	COG1335	isochorismatase
H8S71_RS18045	COG0004	ammonium transporteR
H8S71_RS18050	COG0347	Belongs to the P(II) protein family
H8S71_RS18055	COG0671	phosphoesterase, PA-phosphatase related
H8S71_RS18065	COG0739	heme binding
H8S71_RS18070	COG1247	-acetyltransferase
H8S71_RS18090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_RS18095	COG0789	Transcriptional regulator
H8S71_RS18105	COG2910	NAD(P)H-binding
H8S71_RS18110	COG1959	2 iron, 2 sulfur cluster binding
H8S71_RS18115	COG0804	urea catabolic process
H8S71_RS18120	COG0832	Belongs to the urease beta subunit family
H8S71_RS18125	COG0831	urea catabolic process
H8S71_RS18140	COG3237	CsbD-like
H8S71_RS18145	COG1994	Peptidase M50
H8S71_RS18150	COG0457	Tetratricopeptide repeat
H8S71_RS18155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H8S71_RS18160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H8S71_RS18170	COG2304	oxidoreductase activity
H8S71_RS18180	COG2304	oxidoreductase activity
H8S71_RS18185	COG2385	sporulation resulting in formation of a cellular spore
H8S71_RS18190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8S71_RS18200	COG4836	Membrane
H8S71_RS18210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H8S71_RS18215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H8S71_RS18220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H8S71_RS18225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H8S71_RS18230	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H8S71_RS18235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H8S71_RS18245	COG0356	it plays a direct role in the translocation of protons across the membrane
H8S71_RS18255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H8S71_RS18260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H8S71_RS18265	COG4475	Protein of unknown function (DUF436)
H8S71_RS18270	COG0698	ribose 5-phosphate isomerase
H8S71_RS18275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H8S71_RS18280	COG1971	Probably functions as a manganese efflux pump
H8S71_RS18285	COG0009	L-threonylcarbamoyladenylate synthase
H8S71_RS18290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H8S71_RS18310	COG2890	protein-(glutamine-N5) methyltransferase activity
H8S71_RS18315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H8S71_RS18320	COG0346	lactoylglutathione lyase activity
H8S71_RS18325	COG0789	Transcriptional regulator
H8S71_RS18330	COG0679	Auxin Efflux Carrier
H8S71_RS18335	COG0281	malic enzyme
H8S71_RS18340	COG1435	thymidine kinase activity
H8S71_RS18350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H8S71_RS18360	COG1494	fructose-1,6-bisphosphatase
H8S71_RS18365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H8S71_RS18370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H8S71_RS18375	COG0191	fructose-bisphosphate aldolase activity
H8S71_RS18380	COG2204	response regulator
H8S71_RS18385	COG4821	SIS domain
H8S71_RS18390	COG0504	CTP synthase activity
H8S71_RS18395	COG3343	RNA polymerase activity
H8S71_RS18400	COG1960	acyl-CoA dehydrogenase activity
H8S71_RS18405	COG2181	nitrate reductase activity
H8S71_RS18405	COG0247	lactate metabolic process
H8S71_RS18410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_RS18415	COG4294	response to UV
H8S71_RS18425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_RS18430	COG1132	(ABC) transporter
H8S71_RS18435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H8S71_RS18445	COG2181	nitrate reductase activity
H8S71_RS18450	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H8S71_RS18455	COG1140	nitrate reductase beta subunit
H8S71_RS18460	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H8S71_RS18465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8S71_RS18475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H8S71_RS18480	COG2223	nitrite transmembrane transporter activity
H8S71_RS18485	COG0018	arginyl-trna synthetase
H8S71_RS18490	COG4506	Protein conserved in bacteria
H8S71_RS18505	COG0535	radical SAM domain protein
H8S71_RS18515	COG1131	(ABC) transporter
H8S71_RS18520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H8S71_RS18525	COG0612	Peptidase, M16
H8S71_RS18530	COG0612	Peptidase, M16
H8S71_RS18540	COG3391	amine dehydrogenase activity
H8S71_RS18545	COG3391	amine dehydrogenase activity
H8S71_RS18550	COG0457	Tetratricopeptide repeat
H8S71_RS18580	COG1131	(ABC) transporter
H8S71_RS18590	COG0010	Belongs to the arginase family
H8S71_RS18595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H8S71_RS18600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H8S71_RS18615	COG1994	Peptidase M50
H8S71_RS18620	COG1942	4-Oxalocrotonate Tautomerase
H8S71_RS18625	COG1846	Transcriptional regulator
H8S71_RS18630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H8S71_RS18635	COG0477	Major facilitator Superfamily
H8S71_RS18640	COG1959	2 iron, 2 sulfur cluster binding
H8S71_RS18645	COG3465	dGTPase activity
H8S71_RS18650	COG1078	dGTPase activity
H8S71_RS18655	COG4844	belongs to the
H8S71_RS18665	COG0697	spore germination
H8S71_RS18670	COG0095	Lipoate-protein ligase
H8S71_RS18675	COG0583	DNA-binding transcription factor activity
H8S71_RS18680	COG0280	phosphate acetyltransferase
H8S71_RS18685	COG3253	May function as heme-dependent peroxidase
H8S71_RS18690	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS18695	COG0436	Aminotransferase
H8S71_RS18700	COG2814	Major facilitator Superfamily
H8S71_RS18705	COG0151	Belongs to the GarS family
H8S71_RS18710	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS18715	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS18720	COG0077	Prephenate dehydratase
H8S71_RS18725	COG2814	Major facilitator Superfamily
H8S71_RS18730	COG0833	amino acid
H8S71_RS18735	COG4187	Peptidase family M20/M25/M40
H8S71_RS18740	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS18745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H8S71_RS18755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
H8S71_RS18760	COG1091	dTDP-4-dehydrorhamnose reductase activity
H8S71_RS18765	COG1088	dTDP-glucose 4,6-dehydratase activity
H8S71_RS18770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H8S71_RS18775	COG3980	spore coat polysaccharide biosynthesis protein
H8S71_RS18780	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
H8S71_RS18785	COG2089	acid synthase
H8S71_RS18790	COG0456	acetyltransferase
H8S71_RS18795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H8S71_RS18800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H8S71_RS18805	COG0463	Glycosyl transferase, family 2
H8S71_RS18815	COG2363	Small membrane protein
H8S71_RS18820	COG2233	PERMEase
H8S71_RS18830	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS18835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H8S71_RS18840	COG1216	Glycosyl transferase, family 2
H8S71_RS18855	COG1695	Transcriptional regulator
H8S71_RS18860	COG0351	phosphomethylpyrimidine kinase
H8S71_RS18870	COG1621	beta-fructofuranosidase activity
H8S71_RS18875	COG1263	PTS System
H8S71_RS18875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS18880	COG2116	formate transmembrane transporter activity
H8S71_RS18885	COG3711	transcriptional antiterminator
H8S71_RS18895	COG1404	Belongs to the peptidase S8 family
H8S71_RS18900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS18905	COG0778	Nitroreductase
H8S71_RS18910	COG0772	Belongs to the SEDS family
H8S71_RS18925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H8S71_RS18930	COG1845	cytochrome c oxidase, subunit III
H8S71_RS18935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H8S71_RS18940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H8S71_RS18945	COG2261	transglycosylase associated protein
H8S71_RS18950	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H8S71_RS18955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H8S71_RS18960	COG2246	polysaccharide biosynthetic process
H8S71_RS18965	COG1309	transcriptional regulator
H8S71_RS18975	COG3162	membrane
H8S71_RS18980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H8S71_RS18985	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H8S71_RS18990	COG2837	iron assimilation
H8S71_RS18995	COG2822	iron ion transport
H8S71_RS19000	COG0672	)-iron permease
H8S71_RS19005	COG0352	thiamine-phosphate diphosphorylase activity
H8S71_RS19010	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H8S71_RS19015	COG0583	DNA-binding transcription factor activity
H8S71_RS19020	COG1380	Effector of murein hydrolase LrgA
H8S71_RS19025	COG1346	cytolysis
H8S71_RS19030	COG2814	Major facilitator Superfamily
H8S71_RS19035	COG4895	conserved protein (DUF2196)
H8S71_RS19040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H8S71_RS19045	COG0346	lactoylglutathione lyase activity
H8S71_RS19055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_RS19060	COG1404	Belongs to the peptidase S8 family
H8S71_RS19065	COG1263	PTS System
H8S71_RS19065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS19070	COG3711	transcriptional antiterminator
H8S71_RS19075	COG1442	glycosyl transferase family 8
H8S71_RS19080	COG5522	Integral membrane protein (intg_mem_TP0381)
H8S71_RS19085	COG1846	Transcriptional regulator
H8S71_RS19090	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H8S71_RS19095	COG2234	aminopeptidase activity
H8S71_RS19110	COG2814	Major facilitator Superfamily
H8S71_RS19115	COG2357	RelA SpoT domain protein
H8S71_RS19120	COG1575	Belongs to the MenA family. Type 1 subfamily
H8S71_RS19135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H8S71_RS19140	COG1696	Membrane protein involved in D-alanine export
H8S71_RS19145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H8S71_RS19150	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H8S71_RS19155	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
H8S71_RS19160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H8S71_RS19165	COG1486	melibiose metabolic process
H8S71_RS19170	COG1447	Phosphotransferase system cellobiose-specific component IIA
H8S71_RS19175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_RS19180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H8S71_RS19185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H8S71_RS19185	COG3711	transcriptional antiterminator
H8S71_RS19195	COG2094	Belongs to the DNA glycosylase MPG family
H8S71_RS19200	COG0753	catalase activity
H8S71_RS19205	COG2814	Major facilitator Superfamily
H8S71_RS19210	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H8S71_RS19215	COG1131	(ABC) transporter
H8S71_RS19235	COG1595	DNA-templated transcription, initiation
H8S71_RS19240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H8S71_RS19245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H8S71_RS19250	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H8S71_RS19255	COG4988	ABC transporter
H8S71_RS19260	COG1294	oxidase, subunit
H8S71_RS19265	COG1271	oxidase subunit
H8S71_RS19270	COG3493	citrate carrier protein
H8S71_RS19275	COG0501	Belongs to the peptidase M48B family
H8S71_RS19285	COG0726	polysaccharide deacetylase
H8S71_RS19300	COG3842	ATPase activity
H8S71_RS19305	COG2508	Transcriptional regulator
H8S71_RS19310	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS19315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H8S71_RS19325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H8S71_RS19335	COG4585	Histidine kinase
H8S71_RS19340	COG2197	response regulator
H8S71_RS19345	COG2195	Cleaves the N-terminal amino acid of tripeptides
H8S71_RS19355	COG4894	glucomannan catabolic process
H8S71_RS19360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_RS19365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H8S71_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS19375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H8S71_RS19380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H8S71_RS19385	COG2610	gluconate transmembrane transporter activity
H8S71_RS19390	COG0500	methyltransferase
H8S71_RS19395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_RS19410	COG0753	catalase activity
H8S71_RS19410	COG0693	protein deglycase activity
H8S71_RS19415	COG2851	Citrate transporter
H8S71_RS19420	COG2273	Hydrolase Family 16
H8S71_RS19425	COG3711	transcriptional antiterminator
H8S71_RS19435	COG2270	Major facilitator Superfamily
H8S71_RS19440	COG0513	Belongs to the DEAD box helicase family
H8S71_RS19445	COG3401	FG-GAP repeat protein
H8S71_RS19445	COG2755	lipolytic protein G-D-S-L family
H8S71_RS19475	COG0697	spore germination
H8S71_RS19480	COG0589	response to stress
H8S71_RS19485	COG2723	6-phospho-beta-galactosidase activity
H8S71_RS19490	COG1263	PTS System
H8S71_RS19490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H8S71_RS19490	COG2190	(PTS) system
H8S71_RS19525	COG0494	nUDIX hydrolase
H8S71_RS19530	COG3507	Belongs to the glycosyl hydrolase 43 family
H8S71_RS19545	COG2986	histidine ammonia-lyase
H8S71_RS19550	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H8S71_RS19555	COG1228	amidohydrolase
H8S71_RS19560	COG0010	Belongs to the arginase family
H8S71_RS19565	COG0833	amino acid
H8S71_RS19570	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H8S71_RS19575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H8S71_RS19580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H8S71_RS19585	COG2390	Transcriptional regulator
H8S71_RS19595	COG3192	ethanolamine utilization protein
H8S71_RS19600	COG2079	MmgE PrpD family protein
H8S71_RS19605	COG1473	amidohydrolase
H8S71_RS19610	COG1126	abc transporter atp-binding protein
H8S71_RS19615	COG0765	amino acid transport
H8S71_RS19620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H8S71_RS19625	COG0456	acetyltransferase
H8S71_RS19630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H8S71_RS19635	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H8S71_RS19640	COG0561	phosphatase activity
H8S71_RS19670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H8S71_RS19675	COG5294	Protein conserved in bacteria
H8S71_RS19680	COG0577	efflux transmembrane transporter activity
H8S71_RS19685	COG1136	(ABC) transporter
H8S71_RS19690	COG2205	protein histidine kinase activity
H8S71_RS19695	COG0745	RESPONSE REGULATOR receiver
H8S71_RS19700	COG0191	fructose-bisphosphate aldolase activity
H8S71_RS19705	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_RS19710	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_RS19715	COG0673	inositol 2-dehydrogenase activity
H8S71_RS19720	COG2814	Major facilitator Superfamily
H8S71_RS19725	COG1082	Xylose isomerase domain protein TIM barrel
H8S71_RS19730	COG3962	Belongs to the TPP enzyme family
H8S71_RS19735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H8S71_RS19745	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS19750	COG1349	DNA-binding transcription factor activity
H8S71_RS19755	COG0667	Aldo Keto reductase
H8S71_RS19770	COG2814	Major facilitator Superfamily
H8S71_RS19775	COG0326	Molecular chaperone. Has ATPase activity
H8S71_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS19790	COG1309	transcriptional regulator
H8S71_RS19795	COG1012	belongs to the aldehyde dehydrogenase family
H8S71_RS19805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H8S71_RS19815	COG1714	RDD family
H8S71_RS19820	COG2311	Membrane
H8S71_RS19825	COG1917	Cupin 2, conserved barrel domain protein
H8S71_RS19830	COG1309	transcriptional regulator
H8S71_RS19835	COG1028	Short-chain dehydrogenase reductase Sdr
H8S71_RS19840	COG1846	Transcriptional regulator
H8S71_RS19845	COG1380	Effector of murein hydrolase LrgA
H8S71_RS19850	COG1346	cytolysis
H8S71_RS19855	COG5039	Polysaccharide pyruvyl transferase
H8S71_RS19860	COG1929	Belongs to the glycerate kinase type-1 family
H8S71_RS19865	COG1802	Transcriptional regulator
H8S71_RS19870	COG1070	Carbohydrate kinase
H8S71_RS19875	COG2610	gluconate transmembrane transporter activity
H8S71_RS19880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H8S71_RS19885	COG0450	alkyl hydroperoxide reductase
H8S71_RS19890	COG3634	alkyl hydroperoxide reductase activity
H8S71_RS19895	COG2723	6-phospho-beta-galactosidase activity
H8S71_RS19905	COG2188	Transcriptional regulator
H8S71_RS19920	COG1131	(ABC) transporter
H8S71_RS19925	COG1994	Peptidase M50
H8S71_RS19930	COG0535	radical SAM domain protein
H8S71_RS19940	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H8S71_RS19975	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H8S71_RS19990	COG1063	alcohol dehydrogenase
H8S71_RS20010	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
H8S71_RS20015	COG0456	acetyltransferase
H8S71_RS20020	COG0457	Tetratricopeptide repeat
H8S71_RS20030	COG0010	Belongs to the arginase family
H8S71_RS20035	COG0833	amino acid
H8S71_RS20040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H8S71_RS20045	COG3829	transcription factor binding
H8S71_RS20060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H8S71_RS20065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H8S71_RS20070	COG4853	Protein conserved in bacteria
H8S71_RS20075	COG4863	YycH protein
H8S71_RS20080	COG5002	protein histidine kinase activity
H8S71_RS20085	COG0745	RESPONSE REGULATOR receiver
H8S71_RS20115	COG0346	lactoylglutathione lyase activity
H8S71_RS20120	COG0305	Participates in initiation and elongation during chromosome replication
H8S71_RS20135	COG3093	addiction module antidote protein HigA
H8S71_RS20140	COG2807	transmembrane transport
H8S71_RS20145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H8S71_RS20150	COG0359	binds to the 23S rRNA
H8S71_RS20155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H8S71_RS20160	COG4241	membrane
H8S71_RS20170	COG5577	PFAM Coat F domain
H8S71_RS20175	COG1733	regulation of RNA biosynthetic process
H8S71_RS20180	COG1227	inorganic diphosphatase activity
H8S71_RS20190	COG2271	Major facilitator Superfamily
H8S71_RS20195	COG0789	Transcriptional regulator
H8S71_RS20195	COG4978	Transcriptional regulator
H8S71_RS20205	COG4319	ketosteroid isomerase
H8S71_RS20210	COG1357	PFAM Pentapeptide repeats (8 copies)
H8S71_RS20215	COG2814	Major facilitator Superfamily
H8S71_RS20220	COG0583	DNA-binding transcription factor activity
H8S71_RS20225	COG2153	protein acetylation
H8S71_RS20235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H8S71_RS20240	COG1846	Transcriptional regulator
H8S71_RS20245	COG2153	protein acetylation
H8S71_RS20250	COG2364	Membrane
H8S71_RS20255	COG0456	acetyltransferase
H8S71_RS20260	COG2315	Protein conserved in bacteria
H8S71_RS20265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H8S71_RS20275	COG2814	Major facilitator Superfamily
H8S71_RS20285	COG1331	Highly conserved protein containing a thioredoxin domain
H8S71_RS20290	COG1266	CAAX protease self-immunity
H8S71_RS20295	COG2814	Major facilitator Superfamily
H8S71_RS20295	COG0477	Major facilitator Superfamily
H8S71_RS20300	COG0110	maltose O-acetyltransferase activity
H8S71_RS20305	COG0346	lactoylglutathione lyase activity
H8S71_RS20310	COG1609	Transcriptional regulator
H8S71_RS20315	COG0708	Exodeoxyribonuclease III
H8S71_RS20320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H8S71_RS20325	COG0629	single-stranded DNA binding
H8S71_RS20330	COG0360	Binds together with S18 to 16S ribosomal RNA
H8S71_RS20335	COG0012	GTP binding
H8S71_RS20340	COG0243	molybdopterin cofactor binding
H8S71_RS20345	COG4481	Protein conserved in bacteria
H8S71_RS20350	COG3949	Membrane
H8S71_RS20360	COG1475	DNA binding
H8S71_RS20365	COG1192	Involved in chromosome partitioning
H8S71_RS20375	COG1475	DNA binding
H8S71_RS20380	COG0357	Ribosomal RNA small subunit methyltransferase G
H8S71_RS20385	COG0445	tRNA wobble uridine modification
H8S71_RS20390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H8S71_RS20395	COG1847	R3H domain protein
H8S71_RS20400	COG0706	membrane insertase activity
H8S71_RS20405	COG0594	ribonuclease P activity