locus-tag	class	description
S100333_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S100333_RS00010	COG0592	DNA-directed DNA polymerase activity
S100333_RS00015	COG2501	S4 domain
S100333_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S100333_RS00030	COG0187	DNA topoisomerase II activity
S100333_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100333_RS00070	COG0516	GMP reductase activity
S100333_RS00070	COG0517	IMP dehydrogenase activity
S100333_RS00075	COG1686	Belongs to the peptidase S11 family
S100333_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S100333_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S100333_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S100333_RS00100	COG1428	Deoxynucleoside kinase
S100333_RS00105	COG1428	Deoxynucleoside kinase
S100333_RS00110	COG1388	LysM domain
S100333_RS00110	COG3858	chitin binding
S100333_RS00115	COG1335	isochorismatase
S100333_RS00120	COG0590	tRNA wobble adenosine to inosine editing
S100333_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S100333_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S100333_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S100333_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S100333_RS00190	COG3853	Toxic anion resistance protein (TelA)
S100333_RS00195	COG1982	Orn Lys Arg decarboxylase major
S100333_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S100333_RS00205	COG3870	Protein conserved in bacteria
S100333_RS00210	COG1728	Protein conserved in bacteria
S100333_RS00215	COG0470	DNA polymerase III
S100333_RS00220	COG1774	PSP1 C-terminal conserved region
S100333_RS00225	COG4467	Involved in initiation control of chromosome replication
S100333_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S100333_RS00235	COG2827	Endonuclease containing a URI domain
S100333_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S100333_RS00250	COG2002	toxin-antitoxin pair type II binding
S100333_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_RS00260	COG0084	hydrolase, TatD family'
S100333_RS00265	COG3584	3D domain protein
S100333_RS00265	COG3583	domain protein
S100333_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100333_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S100333_RS00285	COG4466	Protein conserved in bacteria
S100333_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S100333_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_RS00305	COG0251	oxidation-reduction process
S100333_RS00310	COG2088	sporulation resulting in formation of a cellular spore
S100333_RS00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S100333_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S100333_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S100333_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
S100333_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S100333_RS00345	COG2002	toxin-antitoxin pair type II binding
S100333_RS00350	COG2244	polysaccharide biosynthetic process
S100333_RS00355	COG3956	TIGRFAM MazG family protein
S100333_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S100333_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S100333_RS00380	COG1098	S1 RNA binding domain
S100333_RS00395	COG2208	phosphoserine phosphatase activity
S100333_RS00400	COG2304	oxidoreductase activity
S100333_RS00405	COG0515	serine threonine protein kinase
S100333_RS00410	COG0037	tRNA processing
S100333_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S100333_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100333_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S100333_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S100333_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100333_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100333_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100333_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
S100333_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S100333_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S100333_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S100333_RS00475	COG1396	sequence-specific DNA binding
S100333_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100333_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S100333_RS00565	COG4463	regulation of RNA biosynthetic process
S100333_RS00570	COG3880	PFAM UvrB UvrC protein
S100333_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S100333_RS00580	COG0542	response to heat
S100333_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S100333_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S100333_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
S100333_RS00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S100333_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S100333_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S100333_RS00620	COG1045	serine acetyltransferase
S100333_RS00625	COG0215	cysteine-tRNA ligase activity
S100333_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S100333_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100333_RS00640	COG3688	RNA-binding protein containing a PIN domain
S100333_RS00645	COG1595	DNA-templated transcription, initiation
S100333_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100333_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
S100333_RS00670	COG0081	regulation of translation
S100333_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S100333_RS00685	COG2813	Specifically methylates the guanine in position
S100333_RS00690	COG0085	RNA polymerase activity
S100333_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S100333_RS00700	COG1358	cellular component organization or biogenesis
S100333_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S100333_RS00710	COG0049	tRNA binding
S100333_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S100333_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S100333_RS00725	COG0596	Alpha beta hydrolase
S100333_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S100333_RS00740	COG0088	Forms part of the polypeptide exit tunnel
S100333_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S100333_RS00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
S100333_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S100333_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S100333_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S100333_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S100333_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S100333_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S100333_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S100333_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S100333_RS00830	COG0200	Binds to the 23S rRNA
S100333_RS00835	COG0201	protein transport
S100333_RS00840	COG0563	adenylate kinase activity
S100333_RS00845	COG0024	Methionine aminopeptidase
S100333_RS00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S100333_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S100333_RS00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S100333_RS00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S100333_RS00875	COG0202	RNA polymerase activity
S100333_RS00880	COG0203	ribosomal protein L17
S100333_RS00885	COG1122	ATPase activity
S100333_RS00890	COG1122	ATPase activity
S100333_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100333_RS00900	COG0101	tRNA pseudouridine synthase activity
S100333_RS00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S100333_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S100333_RS00920	COG2226	methyltransferase
S100333_RS00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS00935	COG0489	protein tyrosine kinase activity
S100333_RS00945	COG2194	sulfuric ester hydrolase activity
S100333_RS00950	COG0726	polysaccharide deacetylase
S100333_RS01035	COG0659	secondary active sulfate transmembrane transporter activity
S100333_RS01045	COG0385	Bile acid
S100333_RS01050	COG2819	hydrolase of the alpha beta superfamily
S100333_RS01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS01070	COG2207	Transcriptional regulator
S100333_RS01075	COG3876	Protein conserved in bacteria
S100333_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
S100333_RS01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_RS01090	COG1263	PTS System
S100333_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS01100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S100333_RS01105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS01110	COG1683	Conserved Protein
S100333_RS01140	COG1595	DNA-templated transcription, initiation
S100333_RS01145	COG5662	AntiSigma factor
S100333_RS01150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100333_RS01155	COG4856	YbbR-like protein
S100333_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100333_RS01170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S100333_RS01180	COG2169	Transcriptional regulator
S100333_RS01185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100333_RS01190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100333_RS01195	COG3002	Belongs to the UPF0753 family
S100333_RS01200	COG0288	reversible hydration of carbon dioxide
S100333_RS01210	COG5609	conserved protein (DUF2294)
S100333_RS01215	COG0745	RESPONSE REGULATOR receiver
S100333_RS01220	COG0642	Histidine kinase
S100333_RS01230	COG0515	serine threonine protein kinase
S100333_RS01245	COG1113	amino acid transport
S100333_RS01265	COG2602	Beta-lactamase
S100333_RS01270	COG2124	cytochrome p450
S100333_RS01280	COG0531	amino acid
S100333_RS01285	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_RS01290	COG2271	Major facilitator Superfamily
S100333_RS01305	COG0456	acetyltransferase
S100333_RS01305	COG1846	Transcriptional regulator
S100333_RS01325	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS01330	COG0697	spore germination
S100333_RS01335	COG2207	Transcriptional regulator
S100333_RS01335	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS01350	COG3942	CHAP domain
S100333_RS01350	COG1388	LysM domain
S100333_RS01360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S100333_RS01365	COG3591	Belongs to the peptidase S1B family
S100333_RS01375	COG0596	Alpha beta hydrolase
S100333_RS01380	COG1183	phosphatidylcholine synthase activity
S100333_RS01385	COG0586	Pfam SNARE associated Golgi protein
S100333_RS01390	COG0688	phosphatidylethanolamine metabolic process
S100333_RS01400	COG1054	Belongs to the UPF0176 family
S100333_RS01405	COG1301	dicarboxylic acid transport
S100333_RS01410	COG2190	(PTS) system
S100333_RS01410	COG1263	PTS System
S100333_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS01415	COG0363	glucosamine-6-phosphate deaminase activity
S100333_RS01420	COG2188	Transcriptional regulator
S100333_RS01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_RS01435	COG0833	amino acid
S100333_RS01440	COG2040	homocysteine
S100333_RS01455	COG2066	Belongs to the glutaminase family
S100333_RS01460	COG4191	Histidine kinase
S100333_RS01475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100333_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS01485	COG2271	Major facilitator Superfamily
S100333_RS01490	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_RS01495	COG2186	Transcriptional regulator
S100333_RS01500	COG2721	sulfolactate sulfo-lyase activity
S100333_RS01505	COG3173	Aminoglycoside phosphotransferase
S100333_RS01515	COG0697	spore germination
S100333_RS01520	COG0745	RESPONSE REGULATOR receiver
S100333_RS01525	COG2205	protein histidine kinase activity
S100333_RS01530	COG1131	(ABC) transporter
S100333_RS01545	COG3773	Cell wall hydrolase
S100333_RS01550	COG2304	oxidoreductase activity
S100333_RS01560	COG3540	Alkaline phosphatase
S100333_RS01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_RS01570	COG0805	protein transport
S100333_RS01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S100333_RS01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100333_RS01585	COG0477	Major facilitator Superfamily
S100333_RS01590	COG1309	transcriptional regulator
S100333_RS01595	COG0252	asparaginase activity
S100333_RS01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100333_RS01605	COG1714	RDD family
S100333_RS01610	COG3012	SEC-C Motif Domain Protein
S100333_RS01610	COG1405	negative regulation of cell septum assembly
S100333_RS01615	COG3290	protein histidine kinase activity
S100333_RS01625	COG4555	ABC transporter
S100333_RS01630	COG1668	transmembrane transport
S100333_RS01635	COG0667	Aldo Keto reductase
S100333_RS01645	COG1595	DNA-templated transcription, initiation
S100333_RS01655	COG1595	DNA-templated transcription, initiation
S100333_RS01660	COG1876	peptidase activity
S100333_RS01670	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100333_RS01685	COG1121	(ABC) transporter
S100333_RS01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_RS01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_RS01700	COG2310	stress, protein
S100333_RS01705	COG2310	stress, protein
S100333_RS01710	COG2310	stress, protein
S100333_RS01715	COG0861	Integral membrane protein TerC family
S100333_RS01725	COG3853	Toxic anion resistance protein (TelA)
S100333_RS01735	COG0477	Major facilitator Superfamily
S100333_RS01740	COG2814	Major facilitator Superfamily
S100333_RS01745	COG0640	Transcriptional regulator
S100333_RS01750	COG4175	Glycine betaine
S100333_RS01750	COG0517	IMP dehydrogenase activity
S100333_RS01755	COG4176	ABC-type proline glycine betaine transport system permease component
S100333_RS01760	COG2113	Glycine betaine
S100333_RS01765	COG1473	amidohydrolase
S100333_RS01770	COG1288	antiporter activity
S100333_RS01785	COG0039	L-malate dehydrogenase activity
S100333_RS01795	COG2814	Major facilitator Superfamily
S100333_RS01800	COG3403	YqcI/YcgG family
S100333_RS01815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S100333_RS01820	COG1660	Displays ATPase and GTPase activities
S100333_RS01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S100333_RS01840	COG2226	methyltransferase
S100333_RS01845	COG0583	DNA-binding transcription factor activity
S100333_RS01850	COG3458	cephalosporin-C deacetylase activity
S100333_RS01855	COG3541	Predicted nucleotidyltransferase
S100333_RS01860	COG0506	proline dehydrogenase activity
S100333_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS01870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_RS01875	COG2508	Transcriptional regulator
S100333_RS01880	COG3689	TIGRFAM TIGR03943 family protein
S100333_RS01885	COG0701	Predicted permease
S100333_RS01890	COG2267	carboxylic ester hydrolase activity
S100333_RS01895	COG0492	ferredoxin-NADP+ reductase activity
S100333_RS01900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S100333_RS01900	COG1587	Uroporphyrinogen-III synthase
S100333_RS01905	COG2146	nitrite reductase [NAD(P)H] activity
S100333_RS01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_RS01915	COG0243	molybdopterin cofactor binding
S100333_RS01920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_RS01925	COG2223	nitrite transmembrane transporter activity
S100333_RS01930	COG1469	GTP cyclohydrolase I activity
S100333_RS01935	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_RS01950	COG0765	amino acid transport
S100333_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_RS01965	COG1714	RDD family
S100333_RS01975	COG1846	Transcriptional regulator
S100333_RS02000	COG3209	COG3209 Rhs family protein
S100333_RS02010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S100333_RS02015	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S100333_RS02020	COG1733	regulation of RNA biosynthetic process
S100333_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS02040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S100333_RS02045	COG2814	Major facilitator Superfamily
S100333_RS02055	COG0697	spore germination
S100333_RS02065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS02075	COG2364	Membrane
S100333_RS02080	COG1126	abc transporter atp-binding protein
S100333_RS02085	COG0765	amino acid transport
S100333_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_RS02095	COG0583	DNA-binding transcription factor activity
S100333_RS02100	COG0596	Alpha beta hydrolase
S100333_RS02105	COG3104	oligopeptide transport
S100333_RS02110	COG5434	Belongs to the glycosyl hydrolase 28 family
S100333_RS02120	COG0697	spore germination
S100333_RS02130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100333_RS02135	COG1136	(ABC) transporter
S100333_RS02150	COG3850	Histidine kinase
S100333_RS02150	COG5002	protein histidine kinase activity
S100333_RS02155	COG0457	Tetratricopeptide repeat
S100333_RS02175	COG0527	aspartate kinase activity
S100333_RS02180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS02185	COG4605	iron ion homeostasis
S100333_RS02190	COG4604	ABC transporter, ATP-binding protein
S100333_RS02195	COG4607	ABC-type enterochelin transport system periplasmic component
S100333_RS02205	COG2814	Major facilitator Superfamily
S100333_RS02210	COG1309	transcriptional regulator
S100333_RS02215	COG0778	Nitroreductase
S100333_RS02220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100333_RS02225	COG0640	Transcriptional regulator
S100333_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS02235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S100333_RS02240	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS02255	COG4549	nuclear export factor GLE1
S100333_RS02260	COG2372	response to copper ion
S100333_RS02260	COG1276	copper resistance
S100333_RS02265	COG1349	DNA-binding transcription factor activity
S100333_RS02275	COG2213	PTS system mannitol-specific
S100333_RS02280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS02285	COG0246	Mannitol dehydrogenase
S100333_RS02290	COG0473	3-isopropylmalate dehydrogenase activity
S100333_RS02295	COG0681	Belongs to the peptidase S26 family
S100333_RS02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100333_RS02315	COG0561	phosphatase activity
S100333_RS02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S100333_RS02325	COG1914	H( )-stimulated, divalent metal cation uptake system
S100333_RS02330	COG4336	lyase activity
S100333_RS02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S100333_RS02340	COG1984	allophanate hydrolase subunit 2
S100333_RS02345	COG1414	Transcriptional regulator
S100333_RS02350	COG2755	lipolytic protein G-D-S-L family
S100333_RS02360	COG2329	Antibiotic biosynthesis monooxygenase
S100333_RS02365	COG0768	penicillin binding
S100333_RS02370	COG4989	oxidoreductase activity
S100333_RS02375	COG3711	transcriptional antiterminator
S100333_RS02380	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS02385	COG2226	methyltransferase
S100333_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS02395	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS02400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS02405	COG3871	stress protein (general stress protein 26)
S100333_RS02415	COG2814	Major facilitator Superfamily
S100333_RS02420	COG1522	sequence-specific DNA binding
S100333_RS02425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100333_RS02425	COG0551	DNA topoisomerase type I activity
S100333_RS02430	COG0494	nUDIX hydrolase
S100333_RS02435	COG0028	Belongs to the TPP enzyme family
S100333_RS02460	COG1914	H( )-stimulated, divalent metal cation uptake system
S100333_RS02465	COG2261	transglycosylase associated protein
S100333_RS02470	COG4876	unkown
S100333_RS02475	COG2217	Heavy metal translocating P-type atpase
S100333_RS02480	COG3729	General stress protein
S100333_RS02485	COG0662	Cupin 2, conserved barrel domain protein
S100333_RS02490	COG2329	Antibiotic biosynthesis monooxygenase
S100333_RS02495	COG3546	catalase activity
S100333_RS02500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S100333_RS02505	COG3290	protein histidine kinase activity
S100333_RS02510	COG4565	transcriptional regulatory protein
S100333_RS02515	COG1301	dicarboxylic acid transport
S100333_RS02520	COG0628	permease
S100333_RS02525	COG1131	(ABC) transporter
S100333_RS02530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_RS02540	COG1960	acyl-CoA dehydrogenase activity
S100333_RS02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
S100333_RS02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S100333_RS02585	COG0513	Belongs to the DEAD box helicase family
S100333_RS02590	COG3402	PFAM membrane-flanked domain
S100333_RS02595	COG3428	Bacterial PH domain
S100333_RS02600	COG0705	Rhomboid family
S100333_RS02605	COG0736	holo-[acyl-carrier-protein] synthase activity
S100333_RS02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S100333_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100333_RS02620	COG0864	Transcriptional regulator
S100333_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
S100333_RS02630	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS02640	COG2172	sigma factor antagonist activity
S100333_RS02645	COG2208	phosphoserine phosphatase activity
S100333_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS02655	COG2172	sigma factor antagonist activity
S100333_RS02660	COG1191	sigma factor activity
S100333_RS02665	COG2208	phosphoserine phosphatase activity
S100333_RS02670	COG2183	response to ionizing radiation
S100333_RS02680	COG3091	SprT-like family
S100333_RS02725	COG0583	DNA-binding transcription factor activity
S100333_RS02730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS02740	COG5444	nuclease activity
S100333_RS02755	COG5444	nuclease activity
S100333_RS02760	COG1476	TRANSCRIPTIONal
S100333_RS02785	COG0693	protein deglycase activity
S100333_RS02790	COG1278	Cold shock
S100333_RS02795	COG1329	Transcriptional regulator
S100333_RS02810	COG0697	spore germination
S100333_RS02815	COG2207	Transcriptional regulator
S100333_RS02815	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS02820	COG0697	spore germination
S100333_RS02825	COG3708	Transcriptional regulator
S100333_RS02825	COG2207	Transcriptional regulator
S100333_RS02830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS02845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S100333_RS02860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS02865	COG1309	transcriptional regulator
S100333_RS02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS02880	COG2030	dehydratase
S100333_RS02885	COG3545	Serine hydrolase
S100333_RS02890	COG1733	regulation of RNA biosynthetic process
S100333_RS02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS02900	COG0640	Transcriptional regulator
S100333_RS02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100333_RS02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS02920	COG0697	spore germination
S100333_RS02925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS02930	COG0076	glutamate decarboxylase activity
S100333_RS02935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100333_RS02940	COG0640	Transcriptional regulator
S100333_RS02945	COG2197	response regulator
S100333_RS02950	COG2409	Drug exporters of the RND superfamily
S100333_RS02955	COG0596	Alpha beta hydrolase
S100333_RS02960	COG1811	Na channel or pump
S100333_RS02965	COG0789	Transcriptional regulator
S100333_RS02965	COG4978	Transcriptional regulator
S100333_RS02970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_RS02975	COG0778	Nitroreductase
S100333_RS02980	COG0346	lactoylglutathione lyase activity
S100333_RS02985	COG2259	Doxx family
S100333_RS02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS03005	COG2323	membrane
S100333_RS03010	COG2323	membrane
S100333_RS03015	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_RS03030	COG1309	transcriptional regulator
S100333_RS03040	COG0456	acetyltransferase
S100333_RS03045	COG0488	(ABC) transporter
S100333_RS03050	COG1113	amino acid transport
S100333_RS03055	COG2318	DinB family
S100333_RS03060	COG1846	Transcriptional regulator
S100333_RS03065	COG2409	Drug exporters of the RND superfamily
S100333_RS03065	COG1033	growth of symbiont in host cell
S100333_RS03070	COG0778	Nitroreductase
S100333_RS03075	COG1846	Transcriptional regulator
S100333_RS03080	COG2814	Major facilitator Superfamily
S100333_RS03085	COG0730	response to heat
S100333_RS03090	COG1802	Transcriptional regulator
S100333_RS03095	COG1388	LysM domain
S100333_RS03095	COG3858	chitin binding
S100333_RS03100	COG1819	glycosyl
S100333_RS03110	COG1785	Belongs to the alkaline phosphatase family
S100333_RS03115	COG5646	InterPro IPR014922
S100333_RS03125	COG0454	-acetyltransferase
S100333_RS03130	COG1078	dGTPase activity
S100333_RS03135	COG1388	LysM domain
S100333_RS03140	COG2814	Major facilitator Superfamily
S100333_RS03145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_RS03160	COG2723	6-phospho-beta-galactosidase activity
S100333_RS03165	COG2188	Transcriptional regulator
S100333_RS03170	COG1940	carbohydrate kinase activity
S100333_RS03175	COG1482	cell wall glycoprotein biosynthetic process
S100333_RS03180	COG4124	Belongs to the glycosyl hydrolase 26 family
S100333_RS03225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S100333_RS03230	COG0802	atpase or kinase
S100333_RS03235	COG1214	PFAM Peptidase M22, glycoprotease
S100333_RS03240	COG0456	acetyltransferase
S100333_RS03245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S100333_RS03250	COG0488	(ABC) transporter
S100333_RS03255	COG0315	cyclic pyranopterin monophosphate synthase activity
S100333_RS03260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S100333_RS03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_RS03270	COG0805	protein transport
S100333_RS03285	COG1266	CAAX protease self-immunity
S100333_RS03295	COG0459	protein refolding
S100333_RS03300	COG0745	RESPONSE REGULATOR receiver
S100333_RS03310	COG3290	protein histidine kinase activity
S100333_RS03390	COG1063	alcohol dehydrogenase
S100333_RS03395	COG2211	Major facilitator Superfamily
S100333_RS03400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_RS03405	COG1842	Phage shock protein A
S100333_RS03410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100333_RS03420	COG4260	virion core protein, lumpy skin disease virus
S100333_RS03430	COG2814	Major facilitator Superfamily
S100333_RS03435	COG1063	alcohol dehydrogenase
S100333_RS03440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S100333_RS03445	COG0823	Involved in the tonB-independent uptake of proteins
S100333_RS03465	COG2267	carboxylic ester hydrolase activity
S100333_RS03475	COG2132	Multicopper oxidase
S100333_RS03480	COG1113	amino acid transport
S100333_RS03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S100333_RS03495	COG0714	Associated with various cellular activities
S100333_RS03500	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S100333_RS03505	COG1305	Transglutaminase-like
S100333_RS03510	COG0519	Catalyzes the synthesis of GMP from XMP
S100333_RS03510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S100333_RS03525	COG2252	PERMEase
S100333_RS03530	COG3064	Membrane
S100333_RS03540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S100333_RS03550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S100333_RS03555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S100333_RS03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S100333_RS03565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S100333_RS03570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100333_RS03575	COG0047	phosphoribosylformylglycinamidine synthase activity
S100333_RS03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S100333_RS03585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S100333_RS03590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S100333_RS03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S100333_RS03600	COG0138	bifunctional purine biosynthesis protein purh
S100333_RS03605	COG0151	Belongs to the GarS family
S100333_RS03610	COG1522	sequence-specific DNA binding
S100333_RS03615	COG0531	amino acid
S100333_RS03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100333_RS03630	COG1470	cell adhesion involved in biofilm formation
S100333_RS03635	COG4496	protein, YerC YecD
S100333_RS03640	COG0069	glutamate synthase activity
S100333_RS03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S100333_RS03650	COG0210	DNA helicase
S100333_RS03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S100333_RS03660	COG4851	CamS sex pheromone cAM373 precursor
S100333_RS03670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_RS03675	COG1285	pathogenesis
S100333_RS03680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_RS03685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100333_RS03690	COG0154	amidase activity
S100333_RS03695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S100333_RS03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S100333_RS03710	COG1597	lipid kinase activity
S100333_RS03715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100333_RS03780	COG5444	nuclease activity
S100333_RS03785	COG3391	amine dehydrogenase activity
S100333_RS03790	COG0457	Tetratricopeptide repeat
S100333_RS03800	COG0217	transcriptional regulatory protein
S100333_RS03810	COG1309	transcriptional regulator
S100333_RS03825	COG3546	catalase activity
S100333_RS03830	COG0454	-acetyltransferase
S100333_RS03840	COG5578	integral membrane protein
S100333_RS03845	COG2972	Histidine kinase
S100333_RS03855	COG1653	transport
S100333_RS03860	COG1175	transmembrane transport
S100333_RS03865	COG0395	ABC-type sugar transport system, permease component
S100333_RS03870	COG3401	FG-GAP repeat protein
S100333_RS03875	COG3401	FG-GAP repeat protein
S100333_RS03880	COG2755	lipolytic protein G-D-S-L family
S100333_RS03895	COG1653	transport
S100333_RS03900	COG4209	transmembrane transport
S100333_RS03905	COG0395	ABC-type sugar transport system, permease component
S100333_RS03910	COG1486	melibiose metabolic process
S100333_RS03915	COG2323	membrane
S100333_RS03925	COG3328	transposase activity
S100333_RS03930	COG2801	Transposase and inactivated derivatives
S100333_RS03935	COG2329	Antibiotic biosynthesis monooxygenase
S100333_RS03955	COG5583	Uncharacterized small protein (DUF2292)
S100333_RS03960	COG0670	Belongs to the BI1 family
S100333_RS03965	COG0697	spore germination
S100333_RS03970	COG1846	Transcriptional regulator
S100333_RS03990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_RS03990	COG2124	cytochrome p450
S100333_RS03995	COG1368	sulfuric ester hydrolase activity
S100333_RS04000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S100333_RS04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_RS04010	COG1442	glycosyl transferase family 8
S100333_RS04015	COG1216	Glycosyl transferase, family 2
S100333_RS04020	COG1442	glycosyl transferase family 8
S100333_RS04025	COG2223	nitrite transmembrane transporter activity
S100333_RS04030	COG1011	Hydrolase
S100333_RS04035	COG0531	amino acid
S100333_RS04040	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS04045	COG0840	transmembrane signaling receptor activity
S100333_RS04050	COG0488	(ABC) transporter
S100333_RS04060	COG0789	Transcriptional regulator
S100333_RS04065	COG2814	Major facilitator Superfamily
S100333_RS04080	COG0488	(ABC) transporter
S100333_RS04085	COG0513	Belongs to the DEAD box helicase family
S100333_RS04090	COG0456	acetyltransferase
S100333_RS04095	COG3328	transposase activity
S100333_RS04100	COG2130	NADP-dependent
S100333_RS04105	COG1120	ATPase activity
S100333_RS04110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS04115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS04120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100333_RS04140	COG3866	Pectate lyase
S100333_RS04145	COG0471	metal ion transport
S100333_RS04150	COG3290	protein histidine kinase activity
S100333_RS04155	COG4565	transcriptional regulatory protein
S100333_RS04160	COG3181	Tripartite tricarboxylate transporter family receptor
S100333_RS04165	COG2851	Citrate transporter
S100333_RS04170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS04175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S100333_RS04180	COG1254	Belongs to the acylphosphatase family
S100333_RS04185	COG2258	MOSC domain
S100333_RS04205	COG0024	Methionine aminopeptidase
S100333_RS04210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS04210	COG1263	PTS System
S100333_RS04215	COG1368	sulfuric ester hydrolase activity
S100333_RS04230	COG1115	amino acid carrier protein
S100333_RS04240	COG0697	spore germination
S100333_RS04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS04245	COG1263	PTS System
S100333_RS04250	COG0366	Alpha amylase catalytic
S100333_RS04255	COG2188	Transcriptional regulator
S100333_RS04260	COG0778	Nitroreductase
S100333_RS04265	COG0737	Belongs to the 5'-nucleotidase family
S100333_RS04270	COG0693	protein deglycase activity
S100333_RS04275	COG2814	Major facilitator Superfamily
S100333_RS04280	COG4840	Belongs to the UPF0435 family
S100333_RS04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100333_RS04290	COG4980	gas vesicle protein
S100333_RS04295	COG1295	ribonuclease BN
S100333_RS04300	COG0477	Major facilitator Superfamily
S100333_RS04305	COG0387	Pfam Sodium calcium exchanger
S100333_RS04315	COG0668	transmembrane transport
S100333_RS04320	COG0535	radical SAM domain protein
S100333_RS04330	COG0726	polysaccharide deacetylase
S100333_RS04335	COG2084	Dehydrogenase
S100333_RS04340	COG0598	Magnesium transport protein CorA
S100333_RS04345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S100333_RS04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S100333_RS04370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S100333_RS04375	COG4637	Psort location Cytoplasmic, score
S100333_RS04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_RS04390	COG0022	dehydrogenase e1 component
S100333_RS04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_RS04405	COG3284	Transcriptional regulator
S100333_RS04415	COG1742	UPF0060 membrane protein
S100333_RS04440	COG4842	Belongs to the WXG100 family
S100333_RS04445	COG1486	melibiose metabolic process
S100333_RS04450	COG1737	Transcriptional regulator
S100333_RS04460	COG5434	Belongs to the glycosyl hydrolase 28 family
S100333_RS04465	COG1132	(ABC) transporter
S100333_RS04470	COG1132	(ABC) transporter
S100333_RS04475	COG2259	Doxx family
S100333_RS04480	COG2514	catechol 2,3-dioxygenase activity
S100333_RS04485	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS04485	COG4977	sequence-specific DNA binding
S100333_RS04490	COG2814	Major facilitator Superfamily
S100333_RS04495	COG1082	Xylose isomerase domain protein TIM barrel
S100333_RS04505	COG4585	Histidine kinase
S100333_RS04510	COG2197	response regulator
S100333_RS04515	COG1131	(ABC) transporter
S100333_RS04520	COG1511	domain protein
S100333_RS04520	COG0842	Transport permease protein
S100333_RS04525	COG0842	Transport permease protein
S100333_RS04535	COG1695	Transcriptional regulator
S100333_RS04540	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S100333_RS04545	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S100333_RS04550	COG1309	transcriptional regulator
S100333_RS04555	COG2814	Major facilitator Superfamily
S100333_RS04560	COG2318	DinB family
S100333_RS04570	COG1846	Transcriptional regulator
S100333_RS04575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S100333_RS04575	COG0392	lysyltransferase activity
S100333_RS04580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS04585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS04590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS04595	COG0384	phenazine biosynthesis protein PhzF
S100333_RS04600	COG0778	Nitroreductase
S100333_RS04615	COG1090	epimerase
S100333_RS04620	COG2137	regulation of response to DNA damage stimulus
S100333_RS04630	COG2814	Major facilitator Superfamily
S100333_RS04650	COG3103	Sh3 type 3 domain protein
S100333_RS04655	COG5658	integral membrane protein
S100333_RS04660	COG0596	Alpha beta hydrolase
S100333_RS04665	COG0463	Glycosyl transferase, family 2
S100333_RS04670	COG4485	Bacterial membrane protein, YfhO
S100333_RS04675	COG1988	membrane-bound metal-dependent
S100333_RS04680	COG1194	a g-specific adenine glycosylase
S100333_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS04705	COG3557	Belongs to the UPF0374 family
S100333_RS04710	COG1132	(ABC) transporter
S100333_RS04715	COG4129	membrane
S100333_RS04720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100333_RS04725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S100333_RS04730	COG0735	belongs to the Fur family
S100333_RS04840	COG4326	sporulation control protein
S100333_RS04850	COG5577	PFAM Coat F domain
S100333_RS04855	COG3340	Belongs to the peptidase S51 family
S100333_RS04860	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S100333_RS04875	COG0753	catalase activity
S100333_RS04880	COG1116	anion transmembrane transporter activity
S100333_RS04885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100333_RS04890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100333_RS04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_RS04905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S100333_RS04915	COG1476	TRANSCRIPTIONal
S100333_RS04925	COG3382	B3 4 domain protein
S100333_RS04930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S100333_RS04940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S100333_RS04945	COG0789	Transcriptional regulator
S100333_RS04950	COG1664	Polymer-forming cytoskeletal
S100333_RS04955	COG1664	Polymer-forming cytoskeletal
S100333_RS04960	COG2766	serine protein kinase
S100333_RS04965	COG2718	Belongs to the UPF0229 family
S100333_RS04975	COG1566	PFAM secretion protein HlyD family protein
S100333_RS04980	COG2814	Major facilitator Superfamily
S100333_RS04985	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100333_RS05005	COG1725	Transcriptional regulator
S100333_RS05010	COG1131	(ABC) transporter
S100333_RS05015	COG1131	(ABC) transporter
S100333_RS05020	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_RS05025	COG1278	Cold shock
S100333_RS05035	COG1464	Belongs to the NlpA lipoprotein family
S100333_RS05045	COG1823	symporter activity
S100333_RS05050	COG5444	nuclease activity
S100333_RS05075	COG0582	viral genome integration into host DNA
S100333_RS05080	COG2946	Replication initiation factor
S100333_RS05130	COG5644	endopeptidase inhibitor activity
S100333_RS05135	COG0791	NLP P60 protein
S100333_RS05135	COG0741	lytic transglycosylase activity
S100333_RS05155	COG0457	Tetratricopeptide repeat
S100333_RS05180	COG5577	PFAM Coat F domain
S100333_RS05185	COG4085	toxin activity
S100333_RS05185	COG0737	Belongs to the 5'-nucleotidase family
S100333_RS05185	COG1525	nuclease
S100333_RS05190	COG3764	Sortase (surface protein transpeptidase)
S100333_RS05195	COG0564	pseudouridine synthase activity
S100333_RS05205	COG0517	IMP dehydrogenase activity
S100333_RS05210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100333_RS05215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100333_RS05215	COG3153	acetyltransferase
S100333_RS05220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_RS05225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S100333_RS05230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S100333_RS05235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S100333_RS05240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S100333_RS05245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S100333_RS05250	COG4585	Histidine kinase
S100333_RS05250	COG2203	Gaf domain
S100333_RS05255	COG2197	response regulator
S100333_RS05260	COG0431	NADPH-dependent FMN reductase
S100333_RS05275	COG0791	NLP P60 protein
S100333_RS05275	COG1388	LysM domain
S100333_RS05280	COG1959	2 iron, 2 sulfur cluster binding
S100333_RS05285	COG0668	transmembrane transport
S100333_RS05290	COG2719	SpoVR family
S100333_RS05295	COG1785	Belongs to the alkaline phosphatase family
S100333_RS05300	COG1388	LysM domain
S100333_RS05300	COG0791	NLP P60 protein
S100333_RS05305	COG0583	DNA-binding transcription factor activity
S100333_RS05310	COG0372	Belongs to the citrate synthase family
S100333_RS05315	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS05320	COG0531	amino acid
S100333_RS05325	COG0733	neurotransmitter:sodium symporter activity
S100333_RS05330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS05335	COG0456	acetyltransferase
S100333_RS05350	COG1595	DNA-templated transcription, initiation
S100333_RS05355	COG0667	Aldo Keto reductase
S100333_RS05360	COG0204	Acyl-transferase
S100333_RS05365	COG1253	flavin adenine dinucleotide binding
S100333_RS05370	COG0789	Transcriptional regulator
S100333_RS05380	COG1253	flavin adenine dinucleotide binding
S100333_RS05385	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100333_RS05390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S100333_RS05395	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_RS05405	COG0668	transmembrane transport
S100333_RS05410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S100333_RS05415	COG0726	polysaccharide deacetylase
S100333_RS05420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_RS05425	COG1757	Na H antiporter
S100333_RS05430	COG0589	response to stress
S100333_RS05440	COG1132	(ABC) transporter
S100333_RS05445	COG1132	(ABC) transporter
S100333_RS05450	COG0702	epimerase
S100333_RS05470	COG0189	ligase activity
S100333_RS05475	COG0189	ligase activity
S100333_RS05480	COG4399	Belongs to the UPF0754 family
S100333_RS05485	COG3679	Belongs to the UPF0342 family
S100333_RS05490	COG4335	DNA alkylation repair
S100333_RS05495	COG0561	phosphatase activity
S100333_RS05500	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100333_RS05505	COG0475	glutathione-regulated potassium exporter activity
S100333_RS05510	COG0490	domain, Protein
S100333_RS05520	COG1024	Enoyl-CoA hydratase
S100333_RS05530	COG4152	abc transporter atp-binding protein
S100333_RS05535	COG1668	transmembrane transport
S100333_RS05540	COG0420	3'-5' exonuclease activity
S100333_RS05545	COG4717	serine-type aminopeptidase activity
S100333_RS05550	COG3481	metal-dependent phosphohydrolase, HD sub domain
S100333_RS05560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S100333_RS05590	COG1846	Transcriptional regulator
S100333_RS05595	COG4980	gas vesicle protein
S100333_RS05610	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S100333_RS05615	COG0537	adenosine 5'-monophosphoramidase activity
S100333_RS05620	COG1131	(ABC) transporter
S100333_RS05625	COG4473	ABC transporter
S100333_RS05635	COG1473	amidohydrolase
S100333_RS05640	COG3069	C4-dicarboxylate transmembrane transporter activity
S100333_RS05650	COG2329	Antibiotic biosynthesis monooxygenase
S100333_RS05655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_RS05660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S100333_RS05665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S100333_RS05670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S100333_RS05675	COG1309	transcriptional regulator
S100333_RS05680	COG1511	domain protein
S100333_RS05685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_RS05690	COG4377	Putative membrane peptidase family (DUF2324)
S100333_RS05700	COG1363	Peptidase, m42
S100333_RS05705	COG4405	Protein conserved in bacteria
S100333_RS05710	COG1301	dicarboxylic acid transport
S100333_RS05720	COG1234	tRNA 3'-trailer cleavage
S100333_RS05725	COG0095	Lipoate-protein ligase
S100333_RS05730	COG0702	epimerase
S100333_RS05735	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS05745	COG0501	Belongs to the peptidase M48B family
S100333_RS05755	COG0456	acetyltransferase
S100333_RS05760	COG0604	alcohol dehydrogenase
S100333_RS05765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S100333_RS05770	COG0406	alpha-ribazole phosphatase activity
S100333_RS05775	COG0183	Belongs to the thiolase family
S100333_RS05780	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS05785	COG1268	BioY protein
S100333_RS05790	COG0840	transmembrane signaling receptor activity
S100333_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS05815	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS05825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_RS05840	COG0398	Pfam SNARE associated Golgi protein
S100333_RS05845	COG0681	Belongs to the peptidase S26 family
S100333_RS05855	COG1846	Transcriptional regulator
S100333_RS05860	COG0738	Major facilitator superfamily
S100333_RS05865	COG0673	inositol 2-dehydrogenase activity
S100333_RS05870	COG0561	phosphatase activity
S100333_RS05875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_RS05880	COG1609	Transcriptional regulator
S100333_RS05885	COG3180	Ammonia monooxygenase
S100333_RS05890	COG2814	Major facilitator Superfamily
S100333_RS05890	COG0477	Major facilitator Superfamily
S100333_RS05895	COG4533	DNA binding
S100333_RS05905	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S100333_RS05910	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S100333_RS05915	COG1074	ATP-dependent DNA helicase activity
S100333_RS05920	COG0420	3'-5' exonuclease activity
S100333_RS05925	COG0419	ATPase involved in DNA repair
S100333_RS05930	COG1403	HNH endonuclease
S100333_RS05970	COG5337	Spore coat protein CotH
S100333_RS05975	COG0179	Fumarylacetoacetate (FAA) hydrolase
S100333_RS05985	COG1404	Belongs to the peptidase S8 family
S100333_RS05995	COG0367	asparagine synthase
S100333_RS06005	COG0534	Mate efflux family protein
S100333_RS06010	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS06010	COG2207	Transcriptional regulator
S100333_RS06015	COG1609	Transcriptional regulator
S100333_RS06020	COG0673	inositol 2-dehydrogenase activity
S100333_RS06025	COG2318	DinB family
S100333_RS06030	COG1279	arginine transmembrane transporter activity
S100333_RS06035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S100333_RS06040	COG1357	PFAM Pentapeptide repeats (8 copies)
S100333_RS06045	COG2267	carboxylic ester hydrolase activity
S100333_RS06050	COG0454	-acetyltransferase
S100333_RS06055	COG2153	protein acetylation
S100333_RS06060	COG0646	methionine synthase
S100333_RS06060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S100333_RS06065	COG1666	GTP binding
S100333_RS06070	COG2996	Protein conserved in bacteria
S100333_RS06090	COG1695	Transcriptional regulator
S100333_RS06105	COG3227	Zinc metalloprotease (Elastase)
S100333_RS06110	COG1307	EDD domain protein, DegV family
S100333_RS06115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS06130	COG0561	phosphatase activity
S100333_RS06135	COG1073	alpha beta
S100333_RS06140	COG2151	metal-sulfur cluster biosynthetic enzyme
S100333_RS06150	COG0277	FAD linked oxidase domain protein
S100333_RS06160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S100333_RS06165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S100333_RS06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100333_RS06180	COG0505	Belongs to the CarA family
S100333_RS06185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100333_RS06190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S100333_RS06210	COG2267	carboxylic ester hydrolase activity
S100333_RS06220	COG1744	ABC transporter substrate-binding protein PnrA-like
S100333_RS06235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_RS06240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S100333_RS06245	COG5504	Zn-dependent protease
S100333_RS06250	COG0444	Belongs to the ABC transporter superfamily
S100333_RS06255	COG4608	Belongs to the ABC transporter superfamily
S100333_RS06265	COG0601	transmembrane transport
S100333_RS06270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_RS06280	COG0180	Tryptophanyl-tRNA synthetase
S100333_RS06285	COG4166	transmembrane transport
S100333_RS06290	COG0601	transmembrane transport
S100333_RS06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_RS06300	COG0444	Belongs to the ABC transporter superfamily
S100333_RS06305	COG4608	Belongs to the ABC transporter superfamily
S100333_RS06310	COG2814	Major facilitator Superfamily
S100333_RS06315	COG0456	acetyltransferase
S100333_RS06320	COG1393	Belongs to the ArsC family
S100333_RS06325	COG0861	Integral membrane protein TerC family
S100333_RS06330	COG4862	establishment of competence for transformation
S100333_RS06335	COG4469	Competence protein
S100333_RS06340	COG1164	Oligoendopeptidase f
S100333_RS06355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100333_RS06360	COG2346	COG2346, Truncated hemoglobins
S100333_RS06365	COG0741	lytic transglycosylase activity
S100333_RS06370	COG4116	CYTH
S100333_RS06380	COG2357	RelA SpoT domain protein
S100333_RS06385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100333_RS06390	COG0564	pseudouridine synthase activity
S100333_RS06395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S100333_RS06400	COG0475	glutathione-regulated potassium exporter activity
S100333_RS06400	COG0569	domain protein
S100333_RS06405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S100333_RS06410	COG0352	thiamine-phosphate diphosphorylase activity
S100333_RS06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_RS06420	COG2104	thiamine diphosphate biosynthetic process
S100333_RS06425	COG2022	thiamine diphosphate biosynthetic process
S100333_RS06430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_RS06435	COG0351	phosphomethylpyrimidine kinase
S100333_RS06440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S100333_RS06495	COG0210	DNA helicase
S100333_RS06510	COG2153	protein acetylation
S100333_RS06515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100333_RS06520	COG2382	esterase
S100333_RS06525	COG0626	cystathionine gamma-synthase activity
S100333_RS06530	COG0626	cystathionine gamma-synthase activity
S100333_RS06535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS06540	COG5505	Protein of unknown function (DUF819)
S100333_RS06575	COG1396	sequence-specific DNA binding
S100333_RS06650	COG5444	nuclease activity
S100333_RS06660	COG3328	transposase activity
S100333_RS06720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S100333_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS06735	COG3711	transcriptional antiterminator
S100333_RS06735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS06745	COG1482	cell wall glycoprotein biosynthetic process
S100333_RS06760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS06770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S100333_RS06790	COG0109	protoheme IX farnesyltransferase activity
S100333_RS06800	COG0726	polysaccharide deacetylase
S100333_RS06815	COG5504	Zn-dependent protease
S100333_RS06820	COG2205	protein histidine kinase activity
S100333_RS06835	COG2427	Protein of unknown function (DUF1641)
S100333_RS06845	COG1051	belongs to the nudix hydrolase family
S100333_RS06855	COG2124	cytochrome p450
S100333_RS06860	COG1819	glycosyl
S100333_RS06870	COG1587	Uroporphyrinogen-III synthase
S100333_RS06875	COG0390	transport system, permease component
S100333_RS06880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_RS06885	COG0697	spore germination
S100333_RS06900	COG1252	NADH dehydrogenase
S100333_RS06905	COG1904	glucuronate isomerase
S100333_RS06910	COG2211	Major facilitator Superfamily
S100333_RS06915	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S100333_RS06920	COG1063	alcohol dehydrogenase
S100333_RS06925	COG1312	Catalyzes the dehydration of D-mannonate
S100333_RS06930	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS06935	COG2271	Major facilitator Superfamily
S100333_RS06940	COG1609	Transcriptional regulator
S100333_RS06950	COG2721	sulfolactate sulfo-lyase activity
S100333_RS06955	COG0730	response to heat
S100333_RS06965	COG2318	DinB family
S100333_RS06980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S100333_RS06985	COG0457	Tetratricopeptide repeat
S100333_RS07000	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_RS07000	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS07000	COG1388	LysM domain
S100333_RS07010	COG4195	phage-related replication protein
S100333_RS07015	COG3546	catalase activity
S100333_RS07020	COG2856	Zn peptidase
S100333_RS07025	COG1396	sequence-specific DNA binding
S100333_RS07035	COG1522	sequence-specific DNA binding
S100333_RS07040	COG1484	DNA-dependent DNA replication
S100333_RS07060	COG1595	DNA-templated transcription, initiation
S100333_RS07065	COG5484	DNA packaging
S100333_RS07065	COG3728	DNA packaging
S100333_RS07070	COG1783	phage Terminase large subunit
S100333_RS07075	COG5518	Phage portal protein
S100333_RS07080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S100333_RS07085	COG4653	Phage capsid family
S100333_RS07135	COG5412	phage tail tape measure protein
S100333_RS07135	COG3953	SLT domain
S100333_RS07135	COG5412	phage tail tape measure protein
S100333_RS07135	COG5412	phage tail tape measure protein
S100333_RS07135	COG3953	SLT domain
S100333_RS07135	COG3953	SLT domain
S100333_RS07140	COG1652	LysM domain
S100333_RS07145	COG4193	domain, Protein
S100333_RS07155	COG3628	GPW Gp25 family protein
S100333_RS07160	COG3299	homolog of phage Mu protein gp47
S100333_RS07165	COG3778	Protein conserved in bacteria
S100333_RS07205	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_RS07205	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS07220	COG0306	phosphate transporter
S100333_RS07225	COG1392	Phosphate transport regulator
S100333_RS07230	COG0531	amino acid
S100333_RS07235	COG0346	lactoylglutathione lyase activity
S100333_RS07240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100333_RS07245	COG0463	Glycosyl transferase, family 2
S100333_RS07250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_RS07255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_RS07260	COG2362	D-Aminopeptidase
S100333_RS07265	COG0601	transmembrane transport
S100333_RS07270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S100333_RS07275	COG0444	Belongs to the ABC transporter superfamily
S100333_RS07280	COG4166	transmembrane transport
S100333_RS07285	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100333_RS07290	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_RS07295	COG0791	NLP P60 protein
S100333_RS07300	COG4608	Belongs to the ABC transporter superfamily
S100333_RS07305	COG2706	6-phosphogluconolactonase activity
S100333_RS07315	COG1607	acyl-coa hydrolase
S100333_RS07320	COG1017	nitric oxide dioxygenase activity
S100333_RS07320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S100333_RS07330	COG2323	membrane
S100333_RS07335	COG2318	DinB family
S100333_RS07340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS07345	COG2076	Multidrug Resistance protein
S100333_RS07350	COG2076	Multidrug Resistance protein
S100333_RS07355	COG0788	formyltetrahydrofolate deformylase activity
S100333_RS07360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100333_RS07365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S100333_RS07370	COG1764	response to oxidative stress
S100333_RS07375	COG1846	Transcriptional regulator
S100333_RS07380	COG1764	response to oxidative stress
S100333_RS07390	COG0590	tRNA wobble adenosine to inosine editing
S100333_RS07395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_RS07400	COG1404	Belongs to the peptidase S8 family
S100333_RS07405	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS07410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S100333_RS07415	COG1122	ATPase activity
S100333_RS07420	COG4721	ABC-type cobalt transport system, permease component
S100333_RS07430	COG0745	RESPONSE REGULATOR receiver
S100333_RS07440	COG3212	peptidase
S100333_RS07445	COG3212	peptidase
S100333_RS07460	COG2239	Acts as a magnesium transporter
S100333_RS07465	COG0789	Transcriptional regulator
S100333_RS07480	COG1846	Transcriptional regulator
S100333_RS07485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_RS07490	COG0726	polysaccharide deacetylase
S100333_RS07495	COG1408	metallophosphoesterase
S100333_RS07505	COG0463	Glycosyl transferase, family 2
S100333_RS07510	COG1793	dna ligase
S100333_RS07510	COG3285	dna ligase
S100333_RS07515	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S100333_RS07520	COG5001	Diguanylate cyclase
S100333_RS07520	COG3300	MHYT domain
S100333_RS07525	COG0586	Pfam SNARE associated Golgi protein
S100333_RS07530	COG0861	Integral membrane protein TerC family
S100333_RS07535	COG1191	sigma factor activity
S100333_RS07555	COG0501	Belongs to the peptidase M48B family
S100333_RS07560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100333_RS07575	COG3594	Acyltransferase
S100333_RS07580	COG5002	protein histidine kinase activity
S100333_RS07585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S100333_RS07590	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S100333_RS07595	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S100333_RS07600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S100333_RS07605	COG0436	Aminotransferase
S100333_RS07610	COG1850	ribulose-bisphosphate carboxylase activity
S100333_RS07615	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S100333_RS07620	COG0235	Class ii aldolase
S100333_RS07625	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S100333_RS07630	COG3339	Conserved Protein
S100333_RS07645	COG3852	Histidine kinase
S100333_RS07650	COG1846	Transcriptional regulator
S100333_RS07655	COG1360	Flagellar Motor Protein
S100333_RS07660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S100333_RS07665	COG0542	response to heat
S100333_RS07670	COG3949	Membrane
S100333_RS07675	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S100333_RS07680	COG0720	synthase
S100333_RS07685	COG0602	queuosine metabolic process
S100333_RS07690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S100333_RS07700	COG4873	Protein conserved in bacteria
S100333_RS07710	COG3773	Cell wall hydrolase
S100333_RS07715	COG2244	polysaccharide biosynthetic process
S100333_RS07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS07725	COG2217	Heavy metal translocating P-type atpase
S100333_RS07735	COG0006	proline dipeptidase activity
S100333_RS07740	COG1609	Transcriptional regulator
S100333_RS07745	COG3711	transcriptional antiterminator
S100333_RS07750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS07750	COG2190	(PTS) system
S100333_RS07750	COG1263	PTS System
S100333_RS07755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS07760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S100333_RS07770	COG1533	DNA photolyase activity
S100333_RS07775	COG0456	acetyltransferase
S100333_RS07780	COG0840	transmembrane signaling receptor activity
S100333_RS07785	COG2084	Dehydrogenase
S100333_RS07790	COG3328	transposase activity
S100333_RS07795	COG2340	Cysteine-rich secretory protein family
S100333_RS07800	COG0768	penicillin binding
S100333_RS07805	COG4191	Histidine kinase
S100333_RS07810	COG0436	Aminotransferase
S100333_RS07820	COG0835	chemotaxis
S100333_RS07820	COG0784	Response regulator, receiver
S100333_RS07830	COG2814	Major facilitator Superfamily
S100333_RS07835	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_RS07840	COG1408	metallophosphoesterase
S100333_RS07845	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS07850	COG2200	EAL domain
S100333_RS07855	COG4703	Protein of unknown function (DUF1797)
S100333_RS07860	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S100333_RS07870	COG0517	IMP dehydrogenase activity
S100333_RS07875	COG0583	DNA-binding transcription factor activity
S100333_RS07890	COG0716	FMN binding
S100333_RS07895	COG2171	N-acyltransferase activity
S100333_RS07900	COG1473	amidohydrolase
S100333_RS07910	COG0668	transmembrane transport
S100333_RS07915	COG0450	alkyl hydroperoxide reductase
S100333_RS07920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS07940	COG0746	molybdenum cofactor guanylyltransferase activity
S100333_RS07945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_RS07950	COG0303	'Molybdopterin
S100333_RS07955	COG1763	Mo-molybdopterin cofactor biosynthetic process
S100333_RS07960	COG0314	molybdopterin synthase activity
S100333_RS07965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S100333_RS07975	COG1132	(ABC) transporter
S100333_RS07985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100333_RS07990	COG1136	(ABC) transporter
S100333_RS07995	COG0577	efflux transmembrane transporter activity
S100333_RS08000	COG1349	DNA-binding transcription factor activity
S100333_RS08005	COG1105	Belongs to the carbohydrate kinase PfkB family
S100333_RS08010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_RS08010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S100333_RS08010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS08015	COG0681	Belongs to the peptidase S26 family
S100333_RS08025	COG0488	(ABC) transporter
S100333_RS08030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100333_RS08035	COG2309	aminopeptidase activity
S100333_RS08045	COG1077	Cell shape determining protein MreB Mrl
S100333_RS08050	COG2002	toxin-antitoxin pair type II binding
S100333_RS08055	COG3852	Histidine kinase
S100333_RS08060	COG2105	PFAM AIG2 family protein
S100333_RS08060	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S100333_RS08065	COG0569	domain protein
S100333_RS08070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S100333_RS08075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100333_RS08080	COG5503	Protein of unknown function (DUF1447)
S100333_RS08085	COG0561	phosphatase activity
S100333_RS08090	COG0242	peptide deformylase activity
S100333_RS08100	COG0497	DNA recombination
S100333_RS08105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_RS08110	COG0022	dehydrogenase e1 component
S100333_RS08115	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_RS08120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S100333_RS08125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS08135	COG1982	Orn Lys Arg decarboxylase major
S100333_RS08140	COG4476	Belongs to the UPF0223 family
S100333_RS08145	COG4493	Belongs to the UPF0637 family
S100333_RS08155	COG0483	inositol monophosphate 1-phosphatase activity
S100333_RS08165	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S100333_RS08210	COG1217	gtp-binding protein TYPA
S100333_RS08220	COG4896	Protein conserved in bacteria
S100333_RS08230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S100333_RS08235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100333_RS08240	COG2066	Belongs to the glutaminase family
S100333_RS08245	COG4838	Belongs to the UPF0358 family
S100333_RS08250	COG0772	Belongs to the SEDS family
S100333_RS08255	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S100333_RS08260	COG1612	heme a metabolic process
S100333_RS08265	COG0109	protoheme IX farnesyltransferase activity
S100333_RS08270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S100333_RS08270	COG2010	Cytochrome c
S100333_RS08280	COG1845	cytochrome c oxidase, subunit III
S100333_RS08285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100333_RS08290	COG3336	cytochrome c oxidase
S100333_RS08300	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S100333_RS08305	COG2340	Cysteine-rich secretory protein family
S100333_RS08320	COG3679	Belongs to the UPF0342 family
S100333_RS08325	COG4471	UPF0298 protein
S100333_RS08330	COG0742	ribosomal rna small subunit methyltransferase
S100333_RS08335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S100333_RS08340	COG3314	Sporulation integral membrane protein YlbJ
S100333_RS08345	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100333_RS08350	COG3480	Lon protease (S16) C-terminal proteolytic domain
S100333_RS08355	COG1323	Belongs to the UPF0348 family
S100333_RS08365	COG1399	metal-binding, possibly nucleic acid-binding protein
S100333_RS08380	COG0454	-acetyltransferase
S100333_RS08385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S100333_RS08390	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S100333_RS08395	COG2001	Belongs to the MraZ family
S100333_RS08400	COG0275	rRNA processing
S100333_RS08405	COG4839	cell division protein FtsL
S100333_RS08410	COG0768	penicillin binding
S100333_RS08415	COG0768	penicillin binding
S100333_RS08420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S100333_RS08425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100333_RS08430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100333_RS08435	COG0772	Belongs to the SEDS family
S100333_RS08440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_RS08445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S100333_RS08450	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S100333_RS08455	COG3879	Bacterial protein of unknown function (DUF881)
S100333_RS08460	COG3879	Bacterial protein of unknown function (DUF881)
S100333_RS08465	COG3856	small basic protein
S100333_RS08470	COG0849	cell division
S100333_RS08475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S100333_RS08480	COG1404	Belongs to the peptidase S8 family
S100333_RS08480	COG4412	M6 family metalloprotease domain protein
S100333_RS08490	COG1191	sigma factor activity
S100333_RS08495	COG1191	sigma factor activity
S100333_RS08500	COG1119	ATPase activity
S100333_RS08505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_RS08510	COG1873	PFAM PRC-barrel domain
S100333_RS08515	COG1496	oxidoreductase activity
S100333_RS08520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S100333_RS08525	COG1799	cell septum assembly
S100333_RS08530	COG0762	integral membrane protein
S100333_RS08535	COG2302	S4 RNA-binding domain
S100333_RS08540	COG3599	regulation of cell shape
S100333_RS08545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S100333_RS08550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_RS08555	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S100333_RS08560	COG0564	pseudouridine synthase activity
S100333_RS08565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S100333_RS08570	COG2233	PERMEase
S100333_RS08575	COG0540	Belongs to the ATCase OTCase family
S100333_RS08580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100333_RS08585	COG0505	Belongs to the CarA family
S100333_RS08590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S100333_RS08595	COG0543	2 iron, 2 sulfur cluster binding
S100333_RS08600	COG0167	dihydroorotate dehydrogenase activity
S100333_RS08605	COG0284	orotidine-5'-phosphate decarboxylase activity
S100333_RS08610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S100333_RS08615	COG0175	sulfate reduction
S100333_RS08620	COG0306	phosphate transporter
S100333_RS08625	COG2046	Belongs to the sulfate adenylyltransferase family
S100333_RS08630	COG0529	Catalyzes the synthesis of activated sulfate
S100333_RS08640	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S100333_RS08645	COG1648	precorrin-2 dehydrogenase activity
S100333_RS08650	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S100333_RS08655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100333_RS08660	COG1561	YicC-like family, N-terminal region
S100333_RS08670	COG0194	GDP metabolic process
S100333_RS08675	COG1758	RNA polymerase activity
S100333_RS08680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100333_RS08685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S100333_RS08690	COG0242	peptide deformylase activity
S100333_RS08695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S100333_RS08700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100333_RS08700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S100333_RS08705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S100333_RS08710	COG0631	protein serine/threonine phosphatase activity
S100333_RS08715	COG2815	serine threonine protein kinase
S100333_RS08715	COG0515	serine threonine protein kinase
S100333_RS08720	COG1162	GTPase activity
S100333_RS08725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S100333_RS08730	COG1564	THIamine pyrophosphokinase
S100333_RS08740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S100333_RS08745	COG1302	Protein conserved in bacteria
S100333_RS08750	COG1461	Dihydroxyacetone kinase
S100333_RS08755	COG1760	l-serine dehydratase
S100333_RS08760	COG1760	l-serine dehydratase
S100333_RS08765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S100333_RS08770	COG1349	DNA-binding transcription factor activity
S100333_RS08770	COG2050	protein possibly involved in aromatic compounds catabolism
S100333_RS08775	COG0416	fatty acid biosynthetic process
S100333_RS08780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S100333_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS08795	COG0571	ribonuclease III activity
S100333_RS08800	COG1196	nuclear chromosome segregation
S100333_RS08805	COG0552	protein localization to endoplasmic reticulum
S100333_RS08820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S100333_RS08825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S100333_RS08830	COG0228	four-way junction DNA binding
S100333_RS08835	COG1837	Belongs to the UPF0109 family
S100333_RS08845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S100333_RS08850	COG0336	Belongs to the RNA methyltransferase TrmD family
S100333_RS08855	COG0335	large ribosomal subunit rRNA binding
S100333_RS08860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100333_RS08865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100333_RS08875	COG2257	FlhB HrpN YscU SpaS Family
S100333_RS08880	COG0045	succinate-CoA ligase (ADP-forming) activity
S100333_RS08885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S100333_RS08890	COG0758	DNA mediated transformation
S100333_RS08895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S100333_RS08900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S100333_RS08905	COG4974	Belongs to the 'phage' integrase family
S100333_RS08910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S100333_RS08915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S100333_RS08920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100333_RS08925	COG1815	bacterial-type flagellum-dependent cell motility
S100333_RS08930	COG1558	bacterial-type flagellum-dependent cell motility
S100333_RS08935	COG1677	Flagellar hook-basal body complex protein FliE
S100333_RS08940	COG1766	The M ring may be actively involved in energy transduction
S100333_RS08945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_RS08950	COG1317	bacterial-type flagellum organization
S100333_RS08955	COG1157	protein secretion by the type III secretion system
S100333_RS08960	COG2882	bacterial-type flagellum organization
S100333_RS08965	COG3334	PFAM MgtE intracellular
S100333_RS08970	COG3144	bacterial-type flagellum assembly
S100333_RS08975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S100333_RS08980	COG4786	Flagellar basal body rod
S100333_RS08985	COG1582	Flagellar protein (FlbD)
S100333_RS08990	COG1580	Controls the rotational direction of flagella during chemotaxis
S100333_RS08995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_RS09000	COG1776	CheC inhibitor of MCP methylation
S100333_RS09000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S100333_RS09005	COG2201	protein-glutamate methylesterase activity
S100333_RS09010	COG3190	flagellar
S100333_RS09015	COG1338	Plays a role in the flagellum-specific transport system
S100333_RS09020	COG1987	bacterial-type flagellum assembly
S100333_RS09025	COG1684	flagellar biosynthetic protein fliR
S100333_RS09030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100333_RS09035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S100333_RS09040	COG1419	protein localization to endoplasmic reticulum
S100333_RS09045	COG0455	bacterial-type flagellum organization
S100333_RS09050	COG2201	protein-glutamate methylesterase activity
S100333_RS09055	COG2198	Histidine kinase
S100333_RS09055	COG0643	Histidine kinase
S100333_RS09060	COG0835	chemotaxis
S100333_RS09065	COG1776	CheC inhibitor of MCP methylation
S100333_RS09070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S100333_RS09075	COG1191	sigma factor activity
S100333_RS09085	COG0052	Belongs to the universal ribosomal protein uS2 family
S100333_RS09090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S100333_RS09095	COG0528	UMP kinase activity
S100333_RS09100	COG0233	cytoplasmic translational termination
S100333_RS09105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S100333_RS09110	COG4589	Belongs to the CDS family
S100333_RS09115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S100333_RS09120	COG0750	zinc metalloprotease
S100333_RS09125	COG0442	prolyl-tRNA aminoacylation
S100333_RS09130	COG2176	DNA-directed DNA polymerase activity
S100333_RS09135	COG0779	Required for maturation of 30S ribosomal subunits
S100333_RS09140	COG0195	Participates in both transcription termination and antitermination
S100333_RS09145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S100333_RS09150	COG1358	cellular component organization or biogenesis
S100333_RS09155	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
S100333_RS09160	COG1550	Protein conserved in bacteria
S100333_RS09165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S100333_RS09170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S100333_RS09175	COG0196	riboflavin kinase activity
S100333_RS09180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S100333_RS09185	COG1185	polyribonucleotide nucleotidyltransferase activity
S100333_RS09190	COG0726	polysaccharide deacetylase
S100333_RS09195	COG0612	Peptidase, M16
S100333_RS09200	COG1873	PFAM PRC-barrel domain
S100333_RS09205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100333_RS09210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S100333_RS09215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S100333_RS09220	COG0527	aspartate kinase activity
S100333_RS09225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S100333_RS09230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S100333_RS09245	COG4980	gas vesicle protein
S100333_RS09245	COG1674	ftsk spoiiie
S100333_RS09250	COG2188	Transcriptional regulator
S100333_RS09260	COG0612	Peptidase, M16
S100333_RS09265	COG0612	Peptidase, M16
S100333_RS09270	COG0300	oxidoreductase activity
S100333_RS09285	COG1426	Protein conserved in bacteria
S100333_RS09290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S100333_RS09295	COG1058	Belongs to the CinA family
S100333_RS09295	COG1546	Belongs to the CinA family
S100333_RS09300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S100333_RS09305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_RS09310	COG1418	mRNA catabolic process
S100333_RS09315	COG1692	metallophosphoesterase
S100333_RS09320	COG2359	stage V sporulation protein S
S100333_RS09325	COG1063	alcohol dehydrogenase
S100333_RS09330	COG0156	8-amino-7-oxononanoate synthase activity
S100333_RS09335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100333_RS09340	COG4550	Control of competence regulator ComK, YlbF/YmcA
S100333_RS09350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S100333_RS09355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S100333_RS09370	COG3226	Transcriptional regulator
S100333_RS09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS09385	COG1404	Belongs to the peptidase S8 family
S100333_RS09395	COG4195	phage-related replication protein
S100333_RS09400	COG1764	response to oxidative stress
S100333_RS09405	COG2076	Multidrug Resistance protein
S100333_RS09410	COG2076	Multidrug Resistance protein
S100333_RS09425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S100333_RS09430	COG1923	regulation of RNA biosynthetic process
S100333_RS09445	COG1780	Probably involved in ribonucleotide reductase function
S100333_RS09450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100333_RS09455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S100333_RS09460	COG4112	unkown
S100333_RS09465	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS09475	COG0464	growth
S100333_RS09480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S100333_RS09485	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S100333_RS09490	COG0789	Transcriptional regulator
S100333_RS09495	COG0174	glutamine synthetase
S100333_RS09500	COG4974	Belongs to the 'phage' integrase family
S100333_RS09520	COG3645	SOS response
S100333_RS09520	COG3646	Phage regulatory protein
S100333_RS09695	COG5280	Phage tail tape measure protein TP901
S100333_RS09695	COG3953	SLT domain
S100333_RS09705	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_RS09740	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_RS09740	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS09740	COG1388	LysM domain
S100333_RS09750	COG5444	nuclease activity
S100333_RS09790	COG4282	regulation of fungal-type cell wall biogenesis
S100333_RS09800	COG3328	transposase activity
S100333_RS09810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS09825	COG3655	Transcriptional regulator
S100333_RS09850	COG0135	phosphoribosylanthranilate isomerase activity
S100333_RS09855	COG2211	Major facilitator Superfamily
S100333_RS09860	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_RS09865	COG1940	carbohydrate kinase activity
S100333_RS09870	COG2115	Belongs to the xylose isomerase family
S100333_RS09875	COG1070	Carbohydrate kinase
S100333_RS09885	COG3328	transposase activity
S100333_RS09890	COG1525	nuclease
S100333_RS09895	COG2814	Major facilitator Superfamily
S100333_RS09900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S100333_RS09915	COG0756	dUTP diphosphatase activity
S100333_RS09960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S100333_RS09970	COG3832	glyoxalase III activity
S100333_RS10015	COG4195	phage-related replication protein
S100333_RS10025	COG0346	lactoylglutathione lyase activity
S100333_RS10035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S100333_RS10040	COG1388	LysM domain
S100333_RS10045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S100333_RS10050	COG4224	UPF0291 protein
S100333_RS10055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S100333_RS10065	COG3763	UPF0154 protein
S100333_RS10075	COG0785	Cytochrome C biogenesis protein
S100333_RS10080	COG2201	protein-glutamate methylesterase activity
S100333_RS10085	COG4846	Membrane protein involved in cytochrome C biogenesis
S100333_RS10095	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_RS10110	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S100333_RS10115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS10135	COG0824	Thioesterase
S100333_RS10145	COG4841	protein insertion into membrane
S100333_RS10150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S100333_RS10155	COG1832	CoA-binding protein
S100333_RS10160	COG0187	DNA topoisomerase II activity
S100333_RS10165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S100333_RS10175	COG1115	amino acid carrier protein
S100333_RS10180	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S100333_RS10190	COG5520	Belongs to the glycosyl hydrolase 30 family
S100333_RS10200	COG2246	polysaccharide biosynthetic process
S100333_RS10210	COG0586	Pfam SNARE associated Golgi protein
S100333_RS10215	COG2404	hydrolase activity, acting on ester bonds
S100333_RS10220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100333_RS10225	COG1024	Enoyl-CoA hydratase
S100333_RS10235	COG0511	ligase activity, forming carbon-carbon bonds
S100333_RS10240	COG0439	Biotin carboxylase
S100333_RS10245	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS10250	COG1960	acyl-CoA dehydrogenase activity
S100333_RS10260	COG1649	PFAM Uncharacterised BCR, COG1649
S100333_RS10275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS10280	COG2027	D-alanyl-D-alanine carboxypeptidase
S100333_RS10285	COG2017	converts alpha-aldose to the beta-anomer
S100333_RS10290	COG0534	Mate efflux family protein
S100333_RS10305	COG0582	viral genome integration into host DNA
S100333_RS10310	COG0166	Belongs to the GPI family
S100333_RS10315	COG0405	Gamma-glutamyltransferase
S100333_RS10320	COG0583	DNA-binding transcription factor activity
S100333_RS10325	COG0604	alcohol dehydrogenase
S100333_RS10330	COG0493	'glutamate synthase
S100333_RS10335	COG0067	glutamate synthase
S100333_RS10335	COG0069	glutamate synthase activity
S100333_RS10335	COG0070	glutamate synthase
S100333_RS10340	COG0583	DNA-binding transcription factor activity
S100333_RS10345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S100333_RS10350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_RS10360	COG0300	oxidoreductase activity
S100333_RS10365	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100333_RS10375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS10390	COG1131	(ABC) transporter
S100333_RS10400	COG2814	Major facilitator Superfamily
S100333_RS10410	COG2323	membrane
S100333_RS10415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_RS10425	COG2323	membrane
S100333_RS10440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_RS10460	COG3546	catalase activity
S100333_RS10480	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS10500	COG0840	transmembrane signaling receptor activity
S100333_RS10500	COG5278	phosphoserine phosphatase activity
S100333_RS10505	COG2368	4-hydroxyphenylacetate
S100333_RS10515	COG3619	membrane
S100333_RS10560	COG2720	vancomycin resistance protein
S100333_RS10575	COG3739	integral membrane protein
S100333_RS10580	COG0583	DNA-binding transcription factor activity
S100333_RS10585	COG0697	spore germination
S100333_RS10595	COG0693	protein deglycase activity
S100333_RS10600	COG2367	Beta-lactamase
S100333_RS10605	COG4282	regulation of fungal-type cell wall biogenesis
S100333_RS10625	COG0574	Belongs to the PEP-utilizing enzyme family
S100333_RS10625	COG3848	Pyruvate phosphate dikinase
S100333_RS10630	COG0726	polysaccharide deacetylase
S100333_RS10640	COG2314	TM2 domain
S100333_RS10645	COG1396	sequence-specific DNA binding
S100333_RS10650	COG3328	transposase activity
S100333_RS10720	COG3655	Transcriptional regulator
S100333_RS10775	COG0457	Tetratricopeptide repeat
S100333_RS10780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS10790	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_RS10795	COG2226	methyltransferase
S100333_RS10800	COG2211	Major facilitator Superfamily
S100333_RS10805	COG3328	transposase activity
S100333_RS10835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S100333_RS10860	COG4282	regulation of fungal-type cell wall biogenesis
S100333_RS10865	COG1231	oxidoreductase activity
S100333_RS10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_RS10875	COG0662	Cupin 2, conserved barrel domain protein
S100333_RS10875	COG2207	Transcriptional regulator
S100333_RS10885	COG1309	transcriptional regulator
S100333_RS10890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS10895	COG3708	Transcriptional regulator
S100333_RS10900	COG2378	regulation of single-species biofilm formation
S100333_RS10910	COG0640	Transcriptional regulator
S100333_RS10915	COG0741	lytic transglycosylase activity
S100333_RS10920	COG2322	membrane
S100333_RS10935	COG1619	proteins homologs of microcin C7 resistance protein MccF
S100333_RS10940	COG3239	Fatty acid desaturase
S100333_RS10945	COG4585	Histidine kinase
S100333_RS10950	COG2197	response regulator
S100333_RS10955	COG3584	3D domain protein
S100333_RS10955	COG1388	LysM domain
S100333_RS10960	COG0514	ATP-dependent DNA helicase (RecQ)
S100333_RS10975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S100333_RS10995	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_RS11020	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS11030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100333_RS11035	COG0733	neurotransmitter:sodium symporter activity
S100333_RS11040	COG0385	Bile acid
S100333_RS11045	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_RS11050	COG0567	Dehydrogenase, E1 component
S100333_RS11055	COG4548	von Willebrand factor, type A
S100333_RS11060	COG0714	Associated with various cellular activities
S100333_RS11065	COG2032	superoxide dismutase activity
S100333_RS11070	COG0791	NLP P60 protein
S100333_RS11070	COG1388	LysM domain
S100333_RS11075	COG1819	glycosyl
S100333_RS11080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S100333_RS11085	COG0534	Mate efflux family protein
S100333_RS11090	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS11095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_RS11100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_RS11110	COG2962	Rard protein
S100333_RS11130	COG1942	4-Oxalocrotonate Tautomerase
S100333_RS11135	COG1733	regulation of RNA biosynthetic process
S100333_RS11140	COG0778	Nitroreductase
S100333_RS11145	COG0400	carboxylic ester hydrolase activity
S100333_RS11150	COG0346	lactoylglutathione lyase activity
S100333_RS11160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_RS11165	COG0793	Belongs to the peptidase S41A family
S100333_RS11165	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS11170	COG2226	methyltransferase
S100333_RS11180	COG1876	peptidase activity
S100333_RS11185	COG0813	purine-nucleoside phosphorylase activity
S100333_RS11200	COG0671	phosphoesterase, PA-phosphatase related
S100333_RS11225	COG4479	Belongs to the UPF0346 family
S100333_RS11235	COG1509	lysine 2,3-aminomutase activity
S100333_RS11240	COG0456	acetyltransferase
S100333_RS11245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_RS11250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100333_RS11255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100333_RS11260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_RS11270	COG0456	acetyltransferase
S100333_RS11275	COG0463	Glycosyl transferase, family 2
S100333_RS11290	COG4641	Protein conserved in bacteria
S100333_RS11295	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S100333_RS11300	COG1086	Polysaccharide biosynthesis protein
S100333_RS11305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100333_RS11310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S100333_RS11315	COG1846	Transcriptional regulator
S100333_RS11320	COG0534	Mate efflux family protein
S100333_RS11330	COG4698	Protein conserved in bacteria
S100333_RS11335	COG2755	lipolytic protein G-D-S-L family
S100333_RS11340	COG1999	signal sequence binding
S100333_RS11350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S100333_RS11355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100333_RS11360	COG1272	protein, Hemolysin III
S100333_RS11365	COG0204	Acyl-transferase
S100333_RS11370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100333_RS11375	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100333_RS11385	COG2521	methyltransferase
S100333_RS11385	COG2136	Putative SAM-dependent methyltransferase
S100333_RS11395	COG0129	dihydroxy-acid dehydratase activity
S100333_RS11400	COG1413	lyase activity
S100333_RS11405	COG1418	mRNA catabolic process
S100333_RS11410	COG0386	Belongs to the glutathione peroxidase family
S100333_RS11415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S100333_RS11420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S100333_RS11425	COG1278	Cold shock
S100333_RS11445	COG0328	RNA-DNA hybrid ribonuclease activity
S100333_RS11450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S100333_RS11455	COG0328	RNA-DNA hybrid ribonuclease activity
S100333_RS11465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_RS11480	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100333_RS11485	COG1755	Isoprenylcysteine carboxyl methyltransferase
S100333_RS11495	COG2233	PERMEase
S100333_RS11500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_RS11505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S100333_RS11515	COG0800	Aldolase
S100333_RS11520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_RS11525	COG1609	Transcriptional regulator
S100333_RS11530	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S100333_RS11535	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS11540	COG1199	ATP-dependent helicase activity
S100333_RS11555	COG0116	Belongs to the methyltransferase superfamily
S100333_RS11570	COG4474	Belongs to the UPF0398 family
S100333_RS11580	COG3359	exonuclease
S100333_RS11585	COG1111	helicase
S100333_RS11585	COG1205	dead DEAH box helicase
S100333_RS11590	COG2190	(PTS) system
S100333_RS11595	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_RS11630	COG3331	DNA recombination
S100333_RS11635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_RS11635	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100333_RS11645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S100333_RS11650	COG3935	DnaD domain protein
S100333_RS11655	COG0017	Asparaginyl-tRNA synthetase
S100333_RS11660	COG0436	Aminotransferase
S100333_RS11665	COG5353	protein conserved in bacteria
S100333_RS11675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S100333_RS11675	COG1199	ATP-dependent helicase activity
S100333_RS11680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S100333_RS11685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S100333_RS11690	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S100333_RS11695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S100333_RS11695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S100333_RS11700	COG0617	tRNA 3'-terminal CCA addition
S100333_RS11705	COG0438	transferase activity, transferring glycosyl groups
S100333_RS11710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S100333_RS11715	COG1803	Methylglyoxal synthase
S100333_RS11720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S100333_RS11725	COG1694	Mazg nucleotide pyrophosphohydrolase
S100333_RS11730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS11740	COG4347	Protein of unknown function (DUF1405)
S100333_RS11745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100333_RS11745	COG2010	Cytochrome c
S100333_RS11750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S100333_RS11755	COG0723	plastoquinol--plastocyanin reductase activity
S100333_RS11765	COG5582	Belongs to the UPF0302 family
S100333_RS11770	COG0457	Tetratricopeptide repeat
S100333_RS11775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S100333_RS11780	COG0287	Prephenate dehydrogenase
S100333_RS11790	COG0159	tryptophan synthase activity
S100333_RS11795	COG0133	tryptophan synthase activity
S100333_RS11800	COG0135	phosphoribosylanthranilate isomerase activity
S100333_RS11810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S100333_RS11815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S100333_RS11820	COG4401	Chorismate mutase type I
S100333_RS11825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S100333_RS11830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S100333_RS11835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S100333_RS11840	COG0105	UTP biosynthetic process
S100333_RS11845	COG0142	geranyltranstransferase activity
S100333_RS11850	COG2226	methyltransferase
S100333_RS11855	COG0142	geranyltranstransferase activity
S100333_RS11865	COG0302	gtp cyclohydrolase
S100333_RS11870	COG0776	regulation of translation
S100333_RS11875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S100333_RS11890	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S100333_RS11895	COG1160	GTP binding
S100333_RS11925	COG1304	FMN binding
S100333_RS11930	COG0539	negative regulation of cytoplasmic translation
S100333_RS11935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S100333_RS11945	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S100333_RS11950	COG2959	enzyme of heme biosynthesis
S100333_RS11955	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS11955	COG3773	Cell wall hydrolase
S100333_RS11960	COG2339	peptidase activity
S100333_RS11965	COG0492	ferredoxin-NADP+ reductase activity
S100333_RS11970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_RS11975	COG4862	establishment of competence for transformation
S100333_RS11990	COG1388	LysM domain
S100333_RS11995	COG1266	CAAX protease self-immunity
S100333_RS12000	COG0514	ATP-dependent DNA helicase (RecQ)
S100333_RS12005	COG4955	Helix-turn-helix domain
S100333_RS12010	COG1141	Ferredoxin
S100333_RS12015	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S100333_RS12020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S100333_RS12025	COG0710	3-dehydroquinate dehydratase activity
S100333_RS12035	COG1595	DNA-templated transcription, initiation
S100333_RS12040	COG5002	protein histidine kinase activity
S100333_RS12045	COG0745	RESPONSE REGULATOR receiver
S100333_RS12050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100333_RS12055	COG1333	cytochrome c biogenesis protein
S100333_RS12060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS12065	COG1187	pseudouridine synthase activity
S100333_RS12070	COG0700	Nucleoside recognition
S100333_RS12075	COG2715	membrane protein required for spore maturation
S100333_RS12080	COG1686	Belongs to the peptidase S11 family
S100333_RS12090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S100333_RS12095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S100333_RS12100	COG1547	Domain of unknown function (DUF309)
S100333_RS12105	COG0456	acetyltransferase
S100333_RS12110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S100333_RS12115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100333_RS12115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S100333_RS12120	COG0307	riboflavin synthase, alpha
S100333_RS12125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100333_RS12125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S100333_RS12135	COG0681	Belongs to the peptidase S26 family
S100333_RS12145	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S100333_RS12155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_RS12160	COG0739	heme binding
S100333_RS12160	COG0741	lytic transglycosylase activity
S100333_RS12160	COG1196	nuclear chromosome segregation
S100333_RS12195	COG3328	transposase activity
S100333_RS12200	COG3012	SEC-C Motif Domain Protein
S100333_RS12210	COG0457	Tetratricopeptide repeat
S100333_RS12215	COG5444	nuclease activity
S100333_RS12225	COG3328	transposase activity
S100333_RS12275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_RS12280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S100333_RS12290	COG4086	secreted protein
S100333_RS12295	COG0019	diaminopimelate decarboxylase activity
S100333_RS12300	COG0697	spore germination
S100333_RS12315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S100333_RS12335	COG1191	sigma factor activity
S100333_RS12340	COG2172	sigma factor antagonist activity
S100333_RS12345	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS12350	COG1686	Belongs to the peptidase S11 family
S100333_RS12355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S100333_RS12360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S100333_RS12365	COG4974	Belongs to the 'phage' integrase family
S100333_RS12375	COG0735	belongs to the Fur family
S100333_RS12380	COG1300	Membrane
S100333_RS12390	COG0281	malic enzyme
S100333_RS12395	COG1757	Na H antiporter
S100333_RS12400	COG1027	Aspartate ammonia-lyase
S100333_RS12405	COG0252	asparaginase activity
S100333_RS12410	COG1396	sequence-specific DNA binding
S100333_RS12415	COG1379	DNA repair
S100333_RS12420	COG0494	nUDIX hydrolase
S100333_RS12430	COG0667	Aldo Keto reductase
S100333_RS12440	COG1073	alpha beta
S100333_RS12450	COG4918	Iron-sulphur cluster biosynthesis
S100333_RS12455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S100333_RS12455	COG0456	acetyltransferase
S100333_RS12460	COG2329	Antibiotic biosynthesis monooxygenase
S100333_RS12465	COG0456	acetyltransferase
S100333_RS12475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_RS12485	COG2211	Major facilitator Superfamily
S100333_RS12495	COG0346	lactoylglutathione lyase activity
S100333_RS12500	COG1072	(Pantothenic acid kinase))
S100333_RS12505	COG3048	D-serine ammonia-lyase activity
S100333_RS12510	COG0300	oxidoreductase activity
S100333_RS12515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS12520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_RS12525	COG4187	Peptidase family M20/M25/M40
S100333_RS12530	COG1902	pentaerythritol trinitrate reductase activity
S100333_RS12535	COG0596	Alpha beta hydrolase
S100333_RS12545	COG1234	tRNA 3'-trailer cleavage
S100333_RS12550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S100333_RS12555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100333_RS12560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S100333_RS12570	COG0706	membrane insertase activity
S100333_RS12575	COG3361	conserved protein (COG2071)
S100333_RS12580	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100333_RS12585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S100333_RS12590	COG0346	lactoylglutathione lyase activity
S100333_RS12595	COG1376	ErfK ybiS ycfS ynhG family protein
S100333_RS12600	COG4129	membrane
S100333_RS12605	COG1126	abc transporter atp-binding protein
S100333_RS12610	COG0765	amino acid transport
S100333_RS12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_RS12625	COG1597	lipid kinase activity
S100333_RS12635	COG4978	Transcriptional regulator
S100333_RS12635	COG0789	Transcriptional regulator
S100333_RS12640	COG0508	dehydrogenase complex catalyzes the overall conversion of
S100333_RS12645	COG0022	dehydrogenase e1 component
S100333_RS12650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S100333_RS12660	COG3426	butyrate kinase activity
S100333_RS12665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_RS12670	COG0280	phosphate acetyltransferase
S100333_RS12675	COG3829	transcription factor binding
S100333_RS12675	COG3290	protein histidine kinase activity
S100333_RS12685	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S100333_RS12690	COG2079	MmgE PrpD family protein
S100333_RS12695	COG0372	Belongs to the citrate synthase family
S100333_RS12705	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100333_RS12710	COG0183	Belongs to the thiolase family
S100333_RS12715	COG0584	glycerophosphoryl diester phosphodiesterase
S100333_RS12720	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS12730	COG1902	pentaerythritol trinitrate reductase activity
S100333_RS12735	COG0745	RESPONSE REGULATOR receiver
S100333_RS12745	COG0750	zinc metalloprotease
S100333_RS12750	COG0497	DNA recombination
S100333_RS12755	COG1438	arginine binding
S100333_RS12760	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S100333_RS12765	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S100333_RS12770	COG0142	geranyltranstransferase activity
S100333_RS12775	COG1722	exodeoxyribonuclease VII activity
S100333_RS12780	COG1570	exodeoxyribonuclease VII activity
S100333_RS12785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S100333_RS12790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S100333_RS12795	COG1302	Protein conserved in bacteria
S100333_RS12800	COG0439	Biotin carboxylase
S100333_RS12805	COG0511	ligase activity, forming carbon-carbon bonds
S100333_RS12850	COG3854	ATPases associated with a variety of cellular activities
S100333_RS12860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S100333_RS12865	COG0006	proline dipeptidase activity
S100333_RS12870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S100333_RS12880	COG3872	metal-dependent enzyme
S100333_RS12890	COG1752	Esterase of the alpha-beta hydrolase superfamily
S100333_RS12895	COG1321	iron dependent repressor
S100333_RS12900	COG0095	Lipoate-protein ligase
S100333_RS12905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100333_RS12910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100333_RS12915	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S100333_RS12920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S100333_RS12925	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100333_RS12940	COG1396	sequence-specific DNA binding
S100333_RS12950	COG0681	Belongs to the peptidase S26 family
S100333_RS12975	COG4940	Competence protein ComGF
S100333_RS12985	COG4970	Tfp pilus assembly protein FimT
S100333_RS12990	COG4537	Required for transformation and DNA binding
S100333_RS12995	COG1459	type II secretion system
S100333_RS13000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S100333_RS13005	COG0517	IMP dehydrogenase activity
S100333_RS13010	COG0598	Magnesium transport protein CorA
S100333_RS13015	COG1253	flavin adenine dinucleotide binding
S100333_RS13020	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS13030	COG1393	Belongs to the ArsC family
S100333_RS13040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS13050	COG0011	TIGRFAM Protein of
S100333_RS13060	COG2866	Carboxypeptidase
S100333_RS13065	COG1368	sulfuric ester hydrolase activity
S100333_RS13070	COG1940	carbohydrate kinase activity
S100333_RS13075	COG4483	Protein conserved in bacteria
S100333_RS13080	COG0705	Rhomboid family
S100333_RS13080	COG0457	Tetratricopeptide repeat
S100333_RS13090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S100333_RS13100	COG0438	transferase activity, transferring glycosyl groups
S100333_RS13115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100333_RS13120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_RS13125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S100333_RS13130	COG0581	inorganic phosphate transmembrane transporter activity
S100333_RS13135	COG0573	inorganic phosphate transmembrane transporter activity
S100333_RS13140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S100333_RS13145	COG0768	penicillin binding
S100333_RS13150	COG0477	Major facilitator Superfamily
S100333_RS13155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S100333_RS13160	COG2839	Protein conserved in bacteria
S100333_RS13165	COG5521	maltodextrose utilization protein MalA
S100333_RS13170	COG1388	LysM domain
S100333_RS13175	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S100333_RS13180	COG4709	membrane
S100333_RS13185	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S100333_RS13190	COG0735	belongs to the Fur family
S100333_RS13195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS13205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S100333_RS13210	COG0513	Belongs to the DEAD box helicase family
S100333_RS13220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S100333_RS13225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S100333_RS13230	COG2384	SAM-dependent methyltransferase
S100333_RS13235	COG2010	Cytochrome c
S100333_RS13245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S100333_RS13250	COG0358	DNA primase activity
S100333_RS13255	COG1671	Belongs to the UPF0178 family
S100333_RS13260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S100333_RS13265	COG0517	IMP dehydrogenase activity
S100333_RS13270	COG0751	glycine-tRNA ligase activity
S100333_RS13275	COG0752	glycyl-tRNA synthetase alpha subunit
S100333_RS13280	COG1381	Involved in DNA repair and RecF pathway recombination
S100333_RS13290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S100333_RS13295	COG0295	cytidine deaminase activity
S100333_RS13300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S100333_RS13305	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S100333_RS13310	COG1480	7TM receptor with intracellular HD hydrolase
S100333_RS13315	COG1702	phosphate starvation-inducible protein PhoH
S100333_RS13320	COG0561	phosphatase activity
S100333_RS13335	COG4864	UPF0365 protein
S100333_RS13340	COG1030	water channel activity
S100333_RS13345	COG1610	YqeY-like protein
S100333_RS13355	COG1283	sodium-dependent phosphate transmembrane transporter activity
S100333_RS13360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S100333_RS13365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S100333_RS13370	COG2264	protein methyltransferase activity
S100333_RS13375	COG0484	heat shock protein binding
S100333_RS13380	COG0443	Heat shock 70 kDa protein
S100333_RS13385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S100333_RS13390	COG1420	regulation of RNA biosynthetic process
S100333_RS13395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S100333_RS13400	COG0481	GTPase activity
S100333_RS13410	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS13415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S100333_RS13420	COG0268	Binds directly to 16S ribosomal RNA
S100333_RS13425	COG1466	dna polymerase III delta subunit
S100333_RS13435	COG2333	competence protein COMEC
S100333_RS13435	COG0658	competence protein
S100333_RS13440	COG2131	deaminase
S100333_RS13445	COG1555	photosystem II stabilization
S100333_RS13445	COG1596	polysaccharide export
S100333_RS13450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S100333_RS13455	COG2226	methyltransferase
S100333_RS13460	COG0799	negative regulation of ribosome biogenesis
S100333_RS13465	COG1713	HD superfamily hydrolase involved in NAD metabolism
S100333_RS13470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S100333_RS13475	COG1534	Rna-binding protein
S100333_RS13480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S100333_RS13485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S100333_RS13490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S100333_RS13500	COG2755	lipolytic protein G-D-S-L family
S100333_RS13505	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_RS13505	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS13510	COG0398	Pfam SNARE associated Golgi protein
S100333_RS13515	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S100333_RS13525	COG3209	COG3209 Rhs family protein
S100333_RS13540	COG0114	fumarate hydratase activity
S100333_RS13545	COG0583	DNA-binding transcription factor activity
S100333_RS13560	COG0457	Tetratricopeptide repeat
S100333_RS13660	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S100333_RS13665	COG1484	DNA-dependent DNA replication
S100333_RS13680	COG4978	Transcriptional regulator
S100333_RS13680	COG0789	Transcriptional regulator
S100333_RS13685	COG2814	Major facilitator Superfamily
S100333_RS13690	COG0456	acetyltransferase
S100333_RS13695	COG3328	transposase activity
S100333_RS13700	COG1253	flavin adenine dinucleotide binding
S100333_RS13715	COG0583	DNA-binding transcription factor activity
S100333_RS13720	COG2072	flavoprotein involved in K transport
S100333_RS13725	COG1230	cation diffusion facilitator family transporter
S100333_RS13730	COG1942	4-Oxalocrotonate Tautomerase
S100333_RS13735	COG1114	Component of the transport system for branched-chain amino acids
S100333_RS13740	COG1687	branched-chain amino acid
S100333_RS13750	COG1522	sequence-specific DNA binding
S100333_RS13755	COG2732	(Barnase) inhibitor
S100333_RS13760	COG2124	cytochrome p450
S100333_RS13770	COG1335	isochorismatase
S100333_RS13780	COG2318	DinB family
S100333_RS13790	COG2070	2-Nitropropane dioxygenase
S100333_RS13805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100333_RS13820	COG3443	Belongs to the bacterial solute-binding protein 9 family
S100333_RS13825	COG1595	DNA-templated transcription, initiation
S100333_RS13830	COG0667	Aldo Keto reductase
S100333_RS13835	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS13840	COG5566	PFAM Mor transcription activator
S100333_RS13845	COG0596	Alpha beta hydrolase
S100333_RS13850	COG4991	sh3 domain protein
S100333_RS13855	COG4991	sh3 domain protein
S100333_RS13860	COG0346	lactoylglutathione lyase activity
S100333_RS13870	COG5577	PFAM Coat F domain
S100333_RS13875	COG1063	alcohol dehydrogenase
S100333_RS13885	COG5577	PFAM Coat F domain
S100333_RS13890	COG0789	Transcriptional regulator
S100333_RS13900	COG1064	alcohol dehydrogenase
S100333_RS13905	COG0693	protein deglycase activity
S100333_RS13910	COG1621	beta-fructofuranosidase activity
S100333_RS13915	COG3716	PTS system mannose fructose sorbose family IID component
S100333_RS13920	COG3715	PTS system
S100333_RS13925	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS13930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS13935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S100333_RS13935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S100333_RS13940	COG1113	amino acid transport
S100333_RS13945	COG1280	lysine exporter protein (LysE YggA)
S100333_RS13950	COG1378	Sugar-specific transcriptional regulator TrmB
S100333_RS13975	COG2124	cytochrome p450
S100333_RS13975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_RS13980	COG1309	transcriptional regulator
S100333_RS13985	COG2226	methyltransferase
S100333_RS13995	COG2116	formate transmembrane transporter activity
S100333_RS14000	COG5609	conserved protein (DUF2294)
S100333_RS14005	COG3383	formate dehydrogenase (NAD+) activity
S100333_RS14010	COG2427	Protein of unknown function (DUF1641)
S100333_RS14020	COG0626	cystathionine gamma-synthase activity
S100333_RS14025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S100333_RS14030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S100333_RS14035	COG2226	methyltransferase
S100333_RS14050	COG0768	penicillin binding
S100333_RS14055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S100333_RS14060	COG0572	uridine kinase
S100333_RS14065	COG0826	peptidase U32
S100333_RS14070	COG0826	peptidase U32
S100333_RS14075	COG4122	O-methyltransferase activity
S100333_RS14080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S100333_RS14085	COG3906	Belongs to the UPF0473 family
S100333_RS14090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S100333_RS14095	COG4472	Bacterial protein of unknown function (DUF965)
S100333_RS14100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S100333_RS14105	COG0628	permease
S100333_RS14110	COG1126	abc transporter atp-binding protein
S100333_RS14115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_RS14120	COG0765	amino acid transport
S100333_RS14125	COG0765	amino acid transport
S100333_RS14140	COG3881	PFAM PRC-barrel domain
S100333_RS14145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S100333_RS14150	COG0457	Tetratricopeptide repeat
S100333_RS14155	COG0482	sulfurtransferase activity
S100333_RS14160	COG1104	cysteine desulfurase activity
S100333_RS14165	COG1959	2 iron, 2 sulfur cluster binding
S100333_RS14170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S100333_RS14175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S100333_RS14185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S100333_RS14190	COG0124	histidyl-tRNA synthetase
S100333_RS14200	COG4991	sh3 domain protein
S100333_RS14200	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS14200	COG3103	Sh3 type 3 domain protein
S100333_RS14205	COG1490	D-aminoacyl-tRNA deacylase activity
S100333_RS14210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S100333_RS14215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S100333_RS14220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S100333_RS14220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S100333_RS14225	COG5416	Lipopolysaccharide assembly protein A domain
S100333_RS14230	COG0490	domain, Protein
S100333_RS14235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100333_RS14235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S100333_RS14245	COG2244	polysaccharide biosynthetic process
S100333_RS14250	COG2323	membrane
S100333_RS14260	COG1862	Preprotein translocase
S100333_RS14265	COG0343	queuine tRNA-ribosyltransferase activity
S100333_RS14270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S100333_RS14280	COG2255	four-way junction helicase activity
S100333_RS14285	COG0632	four-way junction helicase activity
S100333_RS14295	COG2814	Major facilitator Superfamily
S100333_RS14300	COG0673	inositol 2-dehydrogenase activity
S100333_RS14320	COG1115	amino acid carrier protein
S100333_RS14325	COG0217	transcriptional regulatory protein
S100333_RS14335	COG1388	LysM domain
S100333_RS14340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S100333_RS14345	COG0157	Belongs to the NadC ModD family
S100333_RS14350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S100333_RS14355	COG1104	cysteine desulfurase activity
S100333_RS14360	COG1827	regulation of RNA biosynthetic process
S100333_RS14365	COG0077	Prephenate dehydratase
S100333_RS14370	COG4492	Belongs to the UPF0735 family
S100333_RS14375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S100333_RS14380	COG3290	protein histidine kinase activity
S100333_RS14385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S100333_RS14390	COG2868	ribosomal protein
S100333_RS14395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S100333_RS14400	COG1994	Peptidase M50
S100333_RS14405	COG0739	heme binding
S100333_RS14410	COG2894	cell division
S100333_RS14415	COG0850	regulation of cytokinetic process
S100333_RS14420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S100333_RS14430	COG1077	Cell shape determining protein MreB Mrl
S100333_RS14435	COG2003	Belongs to the UPF0758 family
S100333_RS14440	COG0424	maF-like protein
S100333_RS14450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S100333_RS14455	COG0285	dihydrofolate synthase activity
S100333_RS14460	COG0525	valine-tRNA ligase activity
S100333_RS14470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_RS14475	COG1388	LysM domain
S100333_RS14480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S100333_RS14485	COG0113	porphobilinogen synthase activity
S100333_RS14490	COG1587	Uroporphyrinogen-III synthase
S100333_RS14495	COG0181	hydroxymethylbilane synthase activity
S100333_RS14500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S100333_RS14505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S100333_RS14515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S100333_RS14520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S100333_RS14530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S100333_RS14535	COG0544	peptidyl-prolyl cis-trans isomerase activity
S100333_RS14540	COG0457	Tetratricopeptide repeat
S100333_RS14540	COG1477	protein flavinylation
S100333_RS14545	COG0066	3-isopropylmalate dehydratase activity
S100333_RS14550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S100333_RS14555	COG0473	3-isopropylmalate dehydrogenase activity
S100333_RS14560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S100333_RS14565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S100333_RS14570	COG0440	acetolactate synthase activity
S100333_RS14575	COG0028	Belongs to the TPP enzyme family
S100333_RS14590	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S100333_RS14620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
S100333_RS14645	COG0622	Phosphoesterase
S100333_RS14650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S100333_RS14655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S100333_RS14660	COG5401	PFAM Sporulation and spore germination
S100333_RS14665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S100333_RS14670	COG1846	Transcriptional regulator
S100333_RS14675	COG2197	response regulator
S100333_RS14680	COG0824	Thioesterase
S100333_RS14685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S100333_RS14690	COG1053	succinate dehydrogenase
S100333_RS14695	COG2009	succinate dehydrogenase
S100333_RS14700	COG1719	4-vinyl reductase, 4VR
S100333_RS14705	COG0527	aspartate kinase activity
S100333_RS14715	COG0322	excinuclease ABC activity
S100333_RS14720	COG3118	belongs to the thioredoxin family
S100333_RS14725	COG3534	alpha-L-arabinofuranosidase
S100333_RS14730	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S100333_RS14735	COG2086	electron transfer activity
S100333_RS14740	COG1024	Enoyl-CoA hydratase
S100333_RS14745	COG1309	transcriptional regulator
S100333_RS14750	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS14755	COG3766	membrane
S100333_RS14760	COG1193	negative regulation of DNA recombination
S100333_RS14765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100333_RS14765	COG1796	DNA polymerase
S100333_RS14770	COG1286	toxin biosynthetic process
S100333_RS14775	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S100333_RS14780	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S100333_RS14785	COG0072	phenylalanine-tRNA ligase activity
S100333_RS14785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_RS14790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S100333_RS14800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S100333_RS14810	COG3835	regulator
S100333_RS14815	COG0277	FAD linked oxidase domain protein
S100333_RS14820	COG0247	lactate metabolic process
S100333_RS14825	COG0346	lactoylglutathione lyase activity
S100333_RS14830	COG1966	Carbon starvation protein
S100333_RS14835	COG3534	alpha-L-arabinofuranosidase
S100333_RS14840	COG0395	ABC-type sugar transport system, permease component
S100333_RS14845	COG1175	transmembrane transport
S100333_RS14850	COG1653	transport
S100333_RS14855	COG0371	Dehydrogenase
S100333_RS14860	COG0647	UMP catabolic process
S100333_RS14865	COG0235	Class ii aldolase
S100333_RS14870	COG1069	ribulokinase activity
S100333_RS14875	COG2160	L-arabinose isomerase activity
S100333_RS14880	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_RS14885	COG1363	Peptidase, m42
S100333_RS14895	COG3326	Membrane
S100333_RS14900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S100333_RS14905	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S100333_RS14910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S100333_RS14920	COG1346	cytolysis
S100333_RS14925	COG1380	Effector of murein hydrolase LrgA
S100333_RS14930	COG3279	Response regulator of the LytR AlgR family
S100333_RS14935	COG3275	phosphorelay sensor kinase activity
S100333_RS14940	COG1011	Hydrolase
S100333_RS14945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100333_RS14955	COG0398	Pfam SNARE associated Golgi protein
S100333_RS14960	COG1484	DNA-dependent DNA replication
S100333_RS14965	COG3611	Membrane attachment protein
S100333_RS14970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S100333_RS14975	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S100333_RS14980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100333_RS14985	COG1733	regulation of RNA biosynthetic process
S100333_RS14990	COG2814	Major facilitator Superfamily
S100333_RS14995	COG0656	L-ascorbic acid biosynthetic process
S100333_RS15000	COG0237	dephospho-CoA kinase activity
S100333_RS15005	COG1971	Probably functions as a manganese efflux pump
S100333_RS15010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S100333_RS15015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_RS15015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S100333_RS15025	COG0745	RESPONSE REGULATOR receiver
S100333_RS15030	COG0039	L-malate dehydrogenase activity
S100333_RS15035	COG0538	isocitrate dehydrogenase activity
S100333_RS15040	COG0372	Belongs to the citrate synthase family
S100333_RS15045	COG2707	UPF0756 membrane protein
S100333_RS15050	COG0628	permease
S100333_RS15055	COG3030	protein affecting phage T7 exclusion by the F plasmid
S100333_RS15060	COG0469	pyruvate kinase activity
S100333_RS15065	COG0205	6-phosphofructokinase activity
S100333_RS15070	COG0825	malonyl-CoA metabolic process
S100333_RS15075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S100333_RS15080	COG0281	malic enzyme
S100333_RS15085	COG0587	DNA-directed DNA polymerase activity
S100333_RS15105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S100333_RS15115	COG4109	DRTGG domain
S100333_RS15120	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S100333_RS15125	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS15135	COG0165	Argininosuccinate lyase
S100333_RS15140	COG0137	argininosuccinate synthase activity
S100333_RS15145	COG0521	Mo-molybdopterin cofactor biosynthetic process
S100333_RS15150	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S100333_RS15160	COG0827	DNA restriction-modification system
S100333_RS15165	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S100333_RS15170	COG3874	Sporulation protein YtfJ
S100333_RS15180	COG1714	RDD family
S100333_RS15185	COG0616	signal peptide processing
S100333_RS15190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S100333_RS15195	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S100333_RS15200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100333_RS15210	COG0301	tRNA thio-modification
S100333_RS15215	COG1104	cysteine desulfurase activity
S100333_RS15220	COG1114	Component of the transport system for branched-chain amino acids
S100333_RS15225	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S100333_RS15230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S100333_RS15235	COG1309	transcriptional regulator
S100333_RS15240	COG1956	GAF domain-containing protein
S100333_RS15260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S100333_RS15265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100333_RS15275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S100333_RS15280	COG0454	-acetyltransferase
S100333_RS15285	COG0517	IMP dehydrogenase activity
S100333_RS15290	COG0123	including yeast histone deacetylase and acetoin utilization protein
S100333_RS15295	COG1360	Flagellar Motor Protein
S100333_RS15305	COG1609	Transcriptional regulator
S100333_RS15310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S100333_RS15310	COG1605	Chorismate mutase
S100333_RS15315	COG3118	belongs to the thioredoxin family
S100333_RS15320	COG4980	gas vesicle protein
S100333_RS15325	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S100333_RS15330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S100333_RS15335	COG1674	ftsk spoiiie
S100333_RS15340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S100333_RS15345	COG4848	Belongs to the UPF0354 family
S100333_RS15350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS15360	COG1363	Peptidase, m42
S100333_RS15365	COG5584	Small secreted protein
S100333_RS15370	COG0281	malic enzyme
S100333_RS15375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S100333_RS15380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S100333_RS15390	COG0510	thiamine kinase activity
S100333_RS15395	COG1523	belongs to the glycosyl hydrolase 13 family
S100333_RS15410	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S100333_RS15425	COG2252	PERMEase
S100333_RS15430	COG4473	ABC transporter
S100333_RS15435	COG1131	(ABC) transporter
S100333_RS15440	COG1349	DNA-binding transcription factor activity
S100333_RS15445	COG1187	pseudouridine synthase activity
S100333_RS15455	COG2081	HI0933 family
S100333_RS15460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S100333_RS15470	COG5578	integral membrane protein
S100333_RS15480	COG1653	transport
S100333_RS15485	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S100333_RS15490	COG4209	transmembrane transport
S100333_RS15495	COG2207	Transcriptional regulator
S100333_RS15500	COG1653	transport
S100333_RS15505	COG0395	ABC-type sugar transport system, permease component
S100333_RS15510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_RS15515	COG2124	cytochrome p450
S100333_RS15520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S100333_RS15530	COG0156	8-amino-7-oxononanoate synthase activity
S100333_RS15535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S100333_RS15540	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
S100333_RS15545	COG1073	alpha beta
S100333_RS15550	COG1609	Transcriptional regulator
S100333_RS15555	COG1653	transport
S100333_RS15560	COG1175	transmembrane transport
S100333_RS15565	COG0395	ABC-type sugar transport system, permease component
S100333_RS15570	COG1486	melibiose metabolic process
S100333_RS15575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S100333_RS15580	COG0495	leucyl-tRNA aminoacylation
S100333_RS15590	COG1366	Belongs to the anti-sigma-factor antagonist family
S100333_RS15590	COG2202	Pas domain
S100333_RS15595	COG2814	Major facilitator Superfamily
S100333_RS15600	COG2433	Pfam Transposase IS66
S100333_RS15605	COG0577	efflux transmembrane transporter activity
S100333_RS15610	COG1136	(ABC) transporter
S100333_RS15615	COG2205	protein histidine kinase activity
S100333_RS15620	COG0745	RESPONSE REGULATOR receiver
S100333_RS15625	COG0577	efflux transmembrane transporter activity
S100333_RS15630	COG1136	(ABC) transporter
S100333_RS15645	COG1131	(ABC) transporter
S100333_RS15650	COG1725	Transcriptional regulator
S100333_RS15660	COG1242	4 iron, 4 sulfur cluster binding
S100333_RS15665	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S100333_RS15675	COG2267	carboxylic ester hydrolase activity
S100333_RS15680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S100333_RS15685	COG1113	amino acid transport
S100333_RS15690	COG0367	asparagine synthase
S100333_RS15695	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S100333_RS15700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S100333_RS15710	COG1506	peptidase
S100333_RS15715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S100333_RS15720	COG1116	anion transmembrane transporter activity
S100333_RS15725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S100333_RS15730	COG0494	nUDIX hydrolase
S100333_RS15735	COG4824	toxin secretion phage lysis holin
S100333_RS15740	COG0783	Belongs to the Dps family
S100333_RS15755	COG1854	S-ribosylhomocysteine lyase activity
S100333_RS15760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S100333_RS15765	COG0288	reversible hydration of carbon dioxide
S100333_RS15770	COG0254	rRNA binding
S100333_RS15775	COG1271	oxidase subunit
S100333_RS15780	COG1294	oxidase, subunit
S100333_RS15790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_RS15795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S100333_RS15795	COG1321	iron dependent repressor
S100333_RS15800	COG1121	(ABC) transporter
S100333_RS15805	COG0803	Belongs to the bacterial solute-binding protein 9 family
S100333_RS15810	COG4948	Mandelate Racemase Muconate Lactonizing
S100333_RS15815	COG0318	PFAM AMP-dependent synthetase and ligase
S100333_RS15820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S100333_RS15825	COG0596	Alpha beta hydrolase
S100333_RS15830	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S100333_RS15835	COG1169	isochorismate synthase
S100333_RS15840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S100333_RS15845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_RS15850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_RS15855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S100333_RS15860	COG0438	transferase activity, transferring glycosyl groups
S100333_RS15870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_RS15875	COG0438	transferase activity, transferring glycosyl groups
S100333_RS15880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S100333_RS15885	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S100333_RS15890	COG0058	SHG alpha-glucan phosphorylase activity
S100333_RS15895	COG0297	glycogen (starch) synthase activity
S100333_RS15900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100333_RS15905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S100333_RS15910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S100333_RS16035	COG3859	Proton-coupled thiamine transporter YuaJ
S100333_RS16040	COG1247	-acetyltransferase
S100333_RS16045	COG2268	Band 7 protein
S100333_RS16050	COG1585	Membrane protein implicated in regulation of membrane protease activity
S100333_RS16060	COG2318	DinB family
S100333_RS16070	COG1454	alcohol dehydrogenase
S100333_RS16075	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS16080	COG1510	regulation of RNA biosynthetic process
S100333_RS16095	COG0569	domain protein
S100333_RS16100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S100333_RS16105	COG4682	membrane
S100333_RS16110	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_RS16115	COG0477	Major facilitator Superfamily
S100333_RS16120	COG5553	Cysteine dioxygenase type I
S100333_RS16130	COG1968	undecaprenyl-diphosphatase activity
S100333_RS16135	COG0628	permease
S100333_RS16140	COG0673	inositol 2-dehydrogenase activity
S100333_RS16145	COG4806	L-rhamnose isomerase
S100333_RS16150	COG3254	rhamnose metabolic process
S100333_RS16155	COG1070	Carbohydrate kinase
S100333_RS16160	COG1349	DNA-binding transcription factor activity
S100333_RS16165	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS16165	COG3347	Dehydrogenase
S100333_RS16180	COG0840	transmembrane signaling receptor activity
S100333_RS16185	COG0840	transmembrane signaling receptor activity
S100333_RS16205	COG0432	Pfam Uncharacterised protein family UPF0047
S100333_RS16210	COG0366	Alpha amylase catalytic
S100333_RS16215	COG1253	flavin adenine dinucleotide binding
S100333_RS16220	COG2738	Putative neutral zinc metallopeptidase
S100333_RS16235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S100333_RS16250	COG0166	Belongs to the GPI family
S100333_RS16255	COG1979	alcohol dehydrogenase
S100333_RS16260	COG1979	alcohol dehydrogenase
S100333_RS16265	COG2155	Conserved Protein
S100333_RS16270	COG1098	S1 RNA binding domain
S100333_RS16275	COG0436	Aminotransferase
S100333_RS16280	COG1522	sequence-specific DNA binding
S100333_RS16285	COG2267	carboxylic ester hydrolase activity
S100333_RS16295	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S100333_RS16300	COG2205	protein histidine kinase activity
S100333_RS16310	COG5018	Exonuclease
S100333_RS16320	COG2814	Major facilitator Superfamily
S100333_RS16325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_RS16330	COG3011	Protein conserved in bacteria
S100333_RS16340	COG3290	protein histidine kinase activity
S100333_RS16345	COG4565	transcriptional regulatory protein
S100333_RS16350	COG1744	ABC transporter substrate-binding protein PnrA-like
S100333_RS16355	COG3845	ABC transporter
S100333_RS16360	COG4603	Belongs to the binding-protein-dependent transport system permease family
S100333_RS16365	COG1079	Belongs to the binding-protein-dependent transport system permease family
S100333_RS16370	COG3493	citrate carrier protein
S100333_RS16380	COG2111	Na H antiporter
S100333_RS16380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S100333_RS16385	COG2111	Na H antiporter
S100333_RS16390	COG1006	Multisubunit Na H antiporter MnhC subunit
S100333_RS16395	COG0651	ATP synthesis coupled electron transport
S100333_RS16400	COG1863	multisubunit Na H antiporter MnhE subunit
S100333_RS16405	COG2212	antiporter activity
S100333_RS16410	COG1320	monovalent cation:proton antiporter activity
S100333_RS16415	COG2050	protein possibly involved in aromatic compounds catabolism
S100333_RS16420	COG2197	response regulator
S100333_RS16425	COG4585	Histidine kinase
S100333_RS16435	COG0142	geranyltranstransferase activity
S100333_RS16450	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S100333_RS16455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S100333_RS16460	COG1335	isochorismatase
S100333_RS16465	COG5506	Protein of unknown function (DUF1694)
S100333_RS16480	COG0628	permease
S100333_RS16495	COG1418	mRNA catabolic process
S100333_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS16510	COG1511	domain protein
S100333_RS16515	COG0433	COG0433 Predicted ATPase
S100333_RS16515	COG1674	ftsk spoiiie
S100333_RS16520	COG4499	WXG100 protein secretion system (Wss), protein YukC
S100333_RS16525	COG5417	Belongs to the EsaB family
S100333_RS16530	COG4842	Belongs to the WXG100 family
S100333_RS16540	COG2508	Transcriptional regulator
S100333_RS16540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S100333_RS16545	COG0686	Belongs to the AlaDH PNT family
S100333_RS16550	COG5634	Uncharacterized conserved protein (DUF2278)
S100333_RS16555	COG3251	PFAM MbtH domain protein
S100333_RS16560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS16565	COG1535	isochorismatase
S100333_RS16565	COG3433	isochorismatase activity
S100333_RS16570	COG1021	2,3-dihydroxybenzoate-AMP ligase
S100333_RS16575	COG1169	isochorismate synthase
S100333_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS16585	COG2819	hydrolase of the alpha beta superfamily
S100333_RS16590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S100333_RS16595	COG1268	BioY protein
S100333_RS16600	COG2056	Na+-H+ antiporter family
S100333_RS16605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S100333_RS16610	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S100333_RS16615	COG3584	3D domain protein
S100333_RS16630	COG1252	NADH dehydrogenase
S100333_RS16635	COG0492	ferredoxin-NADP+ reductase activity
S100333_RS16645	COG0516	GMP reductase activity
S100333_RS16655	COG0456	acetyltransferase
S100333_RS16660	COG0316	Belongs to the HesB IscA family
S100333_RS16665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S100333_RS16670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_RS16675	COG4844	belongs to the
S100333_RS16680	COG1252	NADH dehydrogenase
S100333_RS16685	COG4837	Protein of unknown function (DUF1462)
S100333_RS16690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S100333_RS16695	COG0823	Involved in the tonB-independent uptake of proteins
S100333_RS16695	COG1506	peptidase
S100333_RS16695	COG4946	Tricorn protease homolog
S100333_RS16700	COG0083	homoserine kinase activity
S100333_RS16705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S100333_RS16710	COG0460	homoserine dehydrogenase
S100333_RS16720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S100333_RS16725	COG0647	UMP catabolic process
S100333_RS16730	COG2445	Protein of unknown function DUF86
S100333_RS16735	COG4470	Protein conserved in bacteria
S100333_RS16745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S100333_RS16750	COG0739	heme binding
S100333_RS16760	COG3377	Domain of unknown function (DUF1805)
S100333_RS16765	COG0737	Belongs to the 5'-nucleotidase family
S100333_RS16770	COG0730	response to heat
S100333_RS16775	COG1801	Protein of unknown function DUF72
S100333_RS16785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S100333_RS16790	COG2508	Transcriptional regulator
S100333_RS16795	COG2233	PERMEase
S100333_RS16800	COG2233	PERMEase
S100333_RS16805	COG3195	allantoin biosynthetic process
S100333_RS16805	COG3648	Uricase
S100333_RS16810	COG2351	hydroxyisourate hydrolase activity
S100333_RS16825	COG2080	2 iron, 2 sulfur cluster binding
S100333_RS16830	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S100333_RS16835	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S100333_RS16840	COG2068	MobA-Related Protein
S100333_RS16845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S100333_RS16850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S100333_RS16855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S100333_RS16860	COG2356	endonuclease I
S100333_RS16865	COG3842	ATPase activity
S100333_RS16870	COG2188	Transcriptional regulator
S100333_RS16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_RS16885	COG1175	transmembrane transport
S100333_RS16895	COG2222	sugar isomerase
S100333_RS16900	COG0322	excinuclease ABC activity
S100333_RS16905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S100333_RS16925	COG0346	lactoylglutathione lyase activity
S100333_RS16930	COG0640	Transcriptional regulator
S100333_RS16935	COG0719	Fe-S assembly protein
S100333_RS16940	COG0822	iron-sulfur transferase activity
S100333_RS16945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S100333_RS16950	COG0719	Fe-S assembly protein
S100333_RS16955	COG0396	ATPase activity
S100333_RS16970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S100333_RS16975	COG1464	Belongs to the NlpA lipoprotein family
S100333_RS16980	COG2011	ABC-type metal ion transport system permease component
S100333_RS16985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S100333_RS16995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S100333_RS17000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S100333_RS17010	COG0509	glycine decarboxylation via glycine cleavage system
S100333_RS17015	COG1393	Belongs to the ArsC family
S100333_RS17020	COG1960	acyl-CoA dehydrogenase activity
S100333_RS17025	COG0183	Belongs to the thiolase family
S100333_RS17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
S100333_RS17030	COG1024	Enoyl-CoA hydratase
S100333_RS17050	COG5577	PFAM Coat F domain
S100333_RS17055	COG1846	Transcriptional regulator
S100333_RS17060	COG0477	Major facilitator Superfamily
S100333_RS17065	COG1942	4-Oxalocrotonate Tautomerase
S100333_RS17070	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS17075	COG0583	DNA-binding transcription factor activity
S100333_RS17085	COG1120	ATPase activity
S100333_RS17100	COG3328	transposase activity
S100333_RS17115	COG3328	transposase activity
S100333_RS17130	COG1131	(ABC) transporter
S100333_RS17175	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS17180	COG0783	Belongs to the Dps family
S100333_RS17185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_RS17190	COG0745	RESPONSE REGULATOR receiver
S100333_RS17195	COG2205	protein histidine kinase activity
S100333_RS17195	COG2770	Histidine kinase
S100333_RS17205	COG1309	transcriptional regulator
S100333_RS17210	COG0114	fumarate hydratase activity
S100333_RS17220	COG0697	spore germination
S100333_RS17225	COG0814	amino acid
S100333_RS17235	COG2197	response regulator
S100333_RS17240	COG4585	Histidine kinase
S100333_RS17245	COG4758	membrane
S100333_RS17250	COG3595	metallopeptidase activity
S100333_RS17255	COG1842	Phage shock protein A
S100333_RS17260	COG4758	membrane
S100333_RS17265	COG2814	Major facilitator Superfamily
S100333_RS17270	COG2096	Adenosyltransferase
S100333_RS17275	COG1120	ATPase activity
S100333_RS17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS17285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS17290	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS17300	COG3386	PFAM SMP-30 Gluconolaconase
S100333_RS17305	COG2205	protein histidine kinase activity
S100333_RS17310	COG0745	RESPONSE REGULATOR receiver
S100333_RS17320	COG1191	sigma factor activity
S100333_RS17330	COG2140	Oxalate decarboxylase
S100333_RS17340	COG0577	efflux transmembrane transporter activity
S100333_RS17345	COG1136	(ABC) transporter
S100333_RS17350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S100333_RS17355	COG1120	ATPase activity
S100333_RS17360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS17365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S100333_RS17370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS17380	COG0531	amino acid
S100333_RS17395	COG1988	membrane-bound metal-dependent
S100333_RS17400	COG1368	sulfuric ester hydrolase activity
S100333_RS17405	COG1910	domain protein
S100333_RS17410	COG0725	ABC transporter, periplasmic molybdate-binding protein
S100333_RS17415	COG4149	molybdate abc transporter
S100333_RS17420	COG0656	L-ascorbic acid biosynthetic process
S100333_RS17430	COG0025	NhaP-type Na H and K H
S100333_RS17435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S100333_RS17440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S100333_RS17445	COG3973	AAA domain
S100333_RS17450	COG2860	membrane
S100333_RS17455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S100333_RS17460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S100333_RS17465	COG2217	Heavy metal translocating P-type atpase
S100333_RS17470	COG2217	Heavy metal translocating P-type atpase
S100333_RS17475	COG2608	mercury ion transmembrane transporter activity
S100333_RS17480	COG1937	Protein conserved in bacteria
S100333_RS17485	COG0673	inositol 2-dehydrogenase activity
S100333_RS17505	COG2076	Multidrug Resistance protein
S100333_RS17510	COG1309	transcriptional regulator
S100333_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS17525	COG5444	nuclease activity
S100333_RS17540	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS17540	COG5632	N-Acetylmuramoyl-L-alanine amidase
S100333_RS17545	COG4824	toxin secretion phage lysis holin
S100333_RS17570	COG1705	Flagellar rod assembly protein muramidase FlgJ
S100333_RS17570	COG3942	CHAP domain
S100333_RS17690	COG0582	viral genome integration into host DNA
S100333_RS17805	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S100333_RS17810	COG0557	exoribonuclease II activity
S100333_RS17815	COG1647	Serine aminopeptidase, S33
S100333_RS17820	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S100333_RS17825	COG0596	Alpha beta hydrolase
S100333_RS17830	COG1476	TRANSCRIPTIONal
S100333_RS17835	COG1396	sequence-specific DNA binding
S100333_RS17840	COG1396	sequence-specific DNA binding
S100333_RS17845	COG1733	regulation of RNA biosynthetic process
S100333_RS17850	COG0840	transmembrane signaling receptor activity
S100333_RS17855	COG0840	transmembrane signaling receptor activity
S100333_RS17860	COG1174	glycine betaine transport
S100333_RS17865	COG1732	Glycine betaine
S100333_RS17870	COG1174	glycine betaine transport
S100333_RS17880	COG1510	regulation of RNA biosynthetic process
S100333_RS17885	COG1174	glycine betaine transport
S100333_RS17890	COG1732	Glycine betaine
S100333_RS17895	COG1174	glycine betaine transport
S100333_RS17900	COG1125	glycine betaine transport
S100333_RS17900	COG0517	IMP dehydrogenase activity
S100333_RS17905	COG1510	regulation of RNA biosynthetic process
S100333_RS17910	COG2095	MarC family integral membrane protein
S100333_RS17920	COG3064	Membrane
S100333_RS17925	COG4640	response to antibiotic
S100333_RS17930	COG0456	acetyltransferase
S100333_RS17935	COG0148	phosphopyruvate hydratase activity
S100333_RS17940	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S100333_RS17945	COG0149	triose-phosphate isomerase activity
S100333_RS17950	COG0126	phosphoglycerate kinase activity
S100333_RS17955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S100333_RS17960	COG2390	Transcriptional regulator
S100333_RS17965	COG2814	Major facilitator Superfamily
S100333_RS17970	COG1609	Transcriptional regulator
S100333_RS17975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_RS17985	COG0583	DNA-binding transcription factor activity
S100333_RS17995	COG1113	amino acid transport
S100333_RS18005	COG1556	Lactate utilization protein
S100333_RS18010	COG1139	Iron-sulfur cluster binding protein
S100333_RS18015	COG0247	lactate metabolic process
S100333_RS18020	COG2197	response regulator
S100333_RS18025	COG4585	Histidine kinase
S100333_RS18030	COG0842	Transport permease protein
S100333_RS18035	COG1131	(ABC) transporter
S100333_RS18055	COG0596	Alpha beta hydrolase
S100333_RS18060	COG2208	phosphoserine phosphatase activity
S100333_RS18065	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S100333_RS18070	COG1874	Beta-galactosidase
S100333_RS18075	COG3833	ABC-type maltose transport systems, permease component
S100333_RS18080	COG1175	transmembrane transport
S100333_RS18085	COG2182	Extracellular solute-binding protein
S100333_RS18090	COG1609	Transcriptional regulator
S100333_RS18095	COG2186	Transcriptional regulator
S100333_RS18100	COG1620	l-lactate permease
S100333_RS18105	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S100333_RS18115	COG5039	Polysaccharide pyruvyl transferase
S100333_RS18120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_RS18125	COG0110	maltose O-acetyltransferase activity
S100333_RS18130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S100333_RS18135	COG2244	polysaccharide biosynthetic process
S100333_RS18140	COG1216	Glycosyl transferase, family 2
S100333_RS18145	COG5039	Polysaccharide pyruvyl transferase
S100333_RS18150	COG1216	Glycosyl transferase, family 2
S100333_RS18160	COG0438	transferase activity, transferring glycosyl groups
S100333_RS18165	COG1215	transferase activity, transferring glycosyl groups
S100333_RS18170	COG0438	transferase activity, transferring glycosyl groups
S100333_RS18175	COG1086	Polysaccharide biosynthesis protein
S100333_RS18180	COG0489	protein tyrosine kinase activity
S100333_RS18185	COG3944	biosynthesis protein
S100333_RS18190	COG1396	sequence-specific DNA binding
S100333_RS18195	COG2272	Belongs to the type-B carboxylesterase lipase family
S100333_RS18205	COG3479	Phenolic acid decarboxylase
S100333_RS18220	COG1794	racemase activity, acting on amino acids and derivatives
S100333_RS18225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S100333_RS18230	COG1621	beta-fructofuranosidase activity
S100333_RS18235	COG1621	beta-fructofuranosidase activity
S100333_RS18240	COG0531	amino acid
S100333_RS18245	COG1309	transcriptional regulator
S100333_RS18250	COG2076	Multidrug Resistance protein
S100333_RS18255	COG2076	Multidrug Resistance protein
S100333_RS18270	COG0740	serine-type endopeptidase activity
S100333_RS18275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S100333_RS18280	COG0366	Alpha amylase catalytic
S100333_RS18285	COG1554	hydrolase, family 65, central catalytic
S100333_RS18290	COG3833	ABC-type maltose transport systems, permease component
S100333_RS18295	COG1175	transmembrane transport
S100333_RS18300	COG2182	Extracellular solute-binding protein
S100333_RS18305	COG0366	Alpha amylase catalytic
S100333_RS18310	COG1609	Transcriptional regulator
S100333_RS18315	COG1611	Belongs to the LOG family
S100333_RS18325	COG0659	secondary active sulfate transmembrane transporter activity
S100333_RS18330	COG0288	reversible hydration of carbon dioxide
S100333_RS18335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S100333_RS18340	COG0577	efflux transmembrane transporter activity
S100333_RS18345	COG1136	(ABC) transporter
S100333_RS18350	COG5002	protein histidine kinase activity
S100333_RS18355	COG0745	RESPONSE REGULATOR receiver
S100333_RS18365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S100333_RS18370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS18375	COG1481	regulation of sporulation
S100333_RS18380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S100333_RS18385	COG1660	Displays ATPase and GTPase activities
S100333_RS18395	COG0492	ferredoxin-NADP+ reductase activity
S100333_RS18400	COG0791	NLP P60 protein
S100333_RS18400	COG3883	PFAM NLP P60 protein
S100333_RS18405	COG0457	Tetratricopeptide repeat
S100333_RS18410	COG1132	(ABC) transporter
S100333_RS18430	COG0140	phosphoribosyl-ATP diphosphatase activity
S100333_RS18430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S100333_RS18435	COG0107	imidazoleglycerol-phosphate synthase activity
S100333_RS18440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S100333_RS18445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S100333_RS18450	COG0131	Imidazoleglycerol-phosphate dehydratase
S100333_RS18455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S100333_RS18460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S100333_RS18465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S100333_RS18470	COG4990	cell redox homeostasis
S100333_RS18475	COG5297	Belongs to the glycosyl hydrolase family 6
S100333_RS18485	COG0110	maltose O-acetyltransferase activity
S100333_RS18490	COG0546	phosphoglycolate phosphatase activity
S100333_RS18495	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S100333_RS18500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S100333_RS18505	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S100333_RS18510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S100333_RS18515	COG0363	glucosamine-6-phosphate deaminase activity
S100333_RS18520	COG2188	Transcriptional regulator
S100333_RS18525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S100333_RS18530	COG1950	PFAM Membrane protein of
S100333_RS18535	COG1983	PspC domain protein
S100333_RS18540	COG3595	metallopeptidase activity
S100333_RS18555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_RS18560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S100333_RS18565	COG0556	nucleotide-excision repair
S100333_RS18570	COG4897	Protein conserved in bacteria
S100333_RS18575	COG0574	Belongs to the PEP-utilizing enzyme family
S100333_RS18575	COG3848	Pyruvate phosphate dikinase
S100333_RS18580	COG1309	transcriptional regulator
S100333_RS18585	COG2814	Major facilitator Superfamily
S100333_RS18590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_RS18600	COG3409	Peptidoglycan-binding domain 1 protein
S100333_RS18600	COG0793	Belongs to the peptidase S41A family
S100333_RS18605	COG2177	Part of the ABC transporter FtsEX involved in
S100333_RS18610	COG2884	Cell division ATP-binding protein ftsE
S100333_RS18615	COG2010	Cytochrome c
S100333_RS18620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS18630	COG0653	protein targeting
S100333_RS18640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S100333_RS18655	COG1516	flagellar protein fliS
S100333_RS18660	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S100333_RS18665	COG1334	flagellar protein FlaG
S100333_RS18670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_RS18675	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S100333_RS18680	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S100333_RS18690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S100333_RS18695	COG4786	Flagellar basal body rod
S100333_RS18695	COG1256	bacterial-type flagellum assembly
S100333_RS18700	COG3418	PFAM FlgN family protein
S100333_RS18705	COG2747	anti-sigma28 factor FlgM
S100333_RS18715	COG1040	competence protein
S100333_RS18725	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S100333_RS18730	COG1307	EDD domain protein, DegV family
S100333_RS18735	COG2197	response regulator
S100333_RS18740	COG4585	Histidine kinase
S100333_RS18745	COG1739	Uncharacterized protein family UPF0029
S100333_RS18785	COG1131	(ABC) transporter
S100333_RS18795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S100333_RS18800	COG0438	transferase activity, transferring glycosyl groups
S100333_RS18805	COG1215	transferase activity, transferring glycosyl groups
S100333_RS18810	COG3206	protein involved in exopolysaccharide biosynthesis
S100333_RS18815	COG3307	-O-antigen
S100333_RS18825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_RS18835	COG2244	polysaccharide biosynthetic process
S100333_RS18845	COG0860	N-Acetylmuramoyl-L-alanine amidase
S100333_RS18845	COG2247	cell wall binding repeat
S100333_RS18850	COG2385	sporulation resulting in formation of a cellular spore
S100333_RS18850	COG2247	cell wall binding repeat
S100333_RS18865	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S100333_RS18870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S100333_RS18880	COG1134	teichoic acid transport
S100333_RS18885	COG1682	transport, permease protein
S100333_RS18900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_RS18900	COG0463	Glycosyl transferase, family 2
S100333_RS18905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_RS18910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
S100333_RS18915	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
S100333_RS18920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_RS18925	COG4193	domain, Protein
S100333_RS18930	COG1482	cell wall glycoprotein biosynthetic process
S100333_RS18935	COG0697	spore germination
S100333_RS18950	COG2814	Major facilitator Superfamily
S100333_RS18955	COG1316	TRANSCRIPTIONal
S100333_RS18960	COG0561	phosphatase activity
S100333_RS18965	COG0791	NLP P60 protein
S100333_RS18975	COG2843	Capsule synthesis protein
S100333_RS18985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S100333_RS18995	COG1609	Transcriptional regulator
S100333_RS19000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_RS19005	COG1869	D-ribose catabolic process
S100333_RS19010	COG1129	ABC transporter
S100333_RS19015	COG1172	Belongs to the binding-protein-dependent transport system permease family
S100333_RS19025	COG3103	Sh3 type 3 domain protein
S100333_RS19035	COG2249	NAD(P)H dehydrogenase (quinone) activity
S100333_RS19040	COG3527	Alpha-acetolactate decarboxylase
S100333_RS19045	COG0028	Belongs to the TPP enzyme family
S100333_RS19050	COG0583	DNA-binding transcription factor activity
S100333_RS19055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S100333_RS19070	COG5337	Spore coat protein CotH
S100333_RS19080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S100333_RS19090	COG0405	Gamma-glutamyltransferase
S100333_RS19095	COG1522	sequence-specific DNA binding
S100333_RS19100	COG2059	Chromate
S100333_RS19105	COG2059	Chromate
S100333_RS19115	COG0655	NAD(P)H dehydrogenase (quinone) activity
S100333_RS19120	COG0583	DNA-binding transcription factor activity
S100333_RS19150	COG5444	nuclease activity
S100333_RS19170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S100333_RS19175	COG4464	protein tyrosine phosphatase activity
S100333_RS19180	COG0489	protein tyrosine kinase activity
S100333_RS19185	COG3944	biosynthesis protein
S100333_RS19195	COG4715	Zinc finger, swim domain protein
S100333_RS19200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S100333_RS19210	COG0561	phosphatase activity
S100333_RS19215	COG1349	DNA-binding transcription factor activity
S100333_RS19220	COG0629	single-stranded DNA binding
S100333_RS19235	COG3764	Sortase (surface protein transpeptidase)
S100333_RS19240	COG0745	RESPONSE REGULATOR receiver
S100333_RS19240	COG2972	Histidine kinase
S100333_RS19245	COG1970	mechanosensitive ion channel activity
S100333_RS19250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S100333_RS19255	COG0457	Tetratricopeptide repeat
S100333_RS19260	COG4786	Flagellar basal body rod
S100333_RS19265	COG4786	Flagellar basal body rod
S100333_RS19270	COG1077	Cell shape determining protein MreB Mrl
S100333_RS19275	COG1609	Transcriptional regulator
S100333_RS19285	COG1846	Transcriptional regulator
S100333_RS19290	COG2814	Major facilitator Superfamily
S100333_RS19295	COG3420	alginic acid biosynthetic process
S100333_RS19300	COG1953	Uracil, thiamine, allantoin
S100333_RS19305	COG0477	Major facilitator Superfamily
S100333_RS19310	COG1335	isochorismatase
S100333_RS19320	COG0004	ammonium transporteR
S100333_RS19325	COG0347	Belongs to the P(II) protein family
S100333_RS19330	COG0671	phosphoesterase, PA-phosphatase related
S100333_RS19340	COG0739	heme binding
S100333_RS19345	COG1247	-acetyltransferase
S100333_RS19355	COG2089	acid synthase
S100333_RS19365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_RS19370	COG0789	Transcriptional regulator
S100333_RS19385	COG1959	2 iron, 2 sulfur cluster binding
S100333_RS19390	COG0804	urea catabolic process
S100333_RS19395	COG0832	Belongs to the urease beta subunit family
S100333_RS19400	COG0831	urea catabolic process
S100333_RS19415	COG3237	CsbD-like
S100333_RS19420	COG1994	Peptidase M50
S100333_RS19425	COG0457	Tetratricopeptide repeat
S100333_RS19435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S100333_RS19440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S100333_RS19450	COG2304	oxidoreductase activity
S100333_RS19460	COG2304	oxidoreductase activity
S100333_RS19465	COG2385	sporulation resulting in formation of a cellular spore
S100333_RS19470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100333_RS19480	COG4836	Membrane
S100333_RS19490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S100333_RS19495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S100333_RS19500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S100333_RS19505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S100333_RS19510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S100333_RS19515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S100333_RS19525	COG0356	it plays a direct role in the translocation of protons across the membrane
S100333_RS19535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S100333_RS19540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S100333_RS19545	COG4475	Protein of unknown function (DUF436)
S100333_RS19550	COG0698	ribose 5-phosphate isomerase
S100333_RS19555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S100333_RS19560	COG1971	Probably functions as a manganese efflux pump
S100333_RS19565	COG0009	L-threonylcarbamoyladenylate synthase
S100333_RS19570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S100333_RS19590	COG2890	protein-(glutamine-N5) methyltransferase activity
S100333_RS19595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S100333_RS19600	COG0346	lactoylglutathione lyase activity
S100333_RS19605	COG0789	Transcriptional regulator
S100333_RS19610	COG0679	Auxin Efflux Carrier
S100333_RS19615	COG0281	malic enzyme
S100333_RS19620	COG1435	thymidine kinase activity
S100333_RS19630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S100333_RS19635	COG1494	fructose-1,6-bisphosphatase
S100333_RS19640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S100333_RS19645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S100333_RS19650	COG0191	fructose-bisphosphate aldolase activity
S100333_RS19655	COG2204	response regulator
S100333_RS19660	COG4821	SIS domain
S100333_RS19670	COG0504	CTP synthase activity
S100333_RS19675	COG3343	RNA polymerase activity
S100333_RS19680	COG1960	acyl-CoA dehydrogenase activity
S100333_RS19685	COG0247	lactate metabolic process
S100333_RS19685	COG2181	nitrate reductase activity
S100333_RS19690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S100333_RS19695	COG4294	response to UV
S100333_RS19710	COG0018	arginyl-trna synthetase
S100333_RS19715	COG4506	Protein conserved in bacteria
S100333_RS19730	COG0535	radical SAM domain protein
S100333_RS19740	COG1131	(ABC) transporter
S100333_RS19745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S100333_RS19750	COG0612	Peptidase, M16
S100333_RS19755	COG0612	Peptidase, M16
S100333_RS19765	COG3391	amine dehydrogenase activity
S100333_RS19780	COG0457	Tetratricopeptide repeat
S100333_RS19800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S100333_RS19805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S100333_RS19820	COG1994	Peptidase M50
S100333_RS19825	COG1942	4-Oxalocrotonate Tautomerase
S100333_RS19830	COG1846	Transcriptional regulator
S100333_RS19835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S100333_RS19840	COG0477	Major facilitator Superfamily
S100333_RS19845	COG1959	2 iron, 2 sulfur cluster binding
S100333_RS19850	COG3465	dGTPase activity
S100333_RS19855	COG1078	dGTPase activity
S100333_RS19860	COG4844	belongs to the
S100333_RS19870	COG0697	spore germination
S100333_RS19875	COG0095	Lipoate-protein ligase
S100333_RS19880	COG0583	DNA-binding transcription factor activity
S100333_RS19885	COG0280	phosphate acetyltransferase
S100333_RS19890	COG3253	May function as heme-dependent peroxidase
S100333_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS19900	COG2814	Major facilitator Superfamily
S100333_RS19905	COG0833	amino acid
S100333_RS19910	COG4187	Peptidase family M20/M25/M40
S100333_RS19915	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS19920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S100333_RS19930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S100333_RS19935	COG1091	dTDP-4-dehydrorhamnose reductase activity
S100333_RS19940	COG1088	dTDP-glucose 4,6-dehydratase activity
S100333_RS19945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S100333_RS19950	COG3980	spore coat polysaccharide biosynthesis protein
S100333_RS19955	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S100333_RS19960	COG2089	acid synthase
S100333_RS19965	COG0456	acetyltransferase
S100333_RS19970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S100333_RS19975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S100333_RS19980	COG0463	Glycosyl transferase, family 2
S100333_RS19995	COG2363	Small membrane protein
S100333_RS20000	COG2233	PERMEase
S100333_RS20010	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS20015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S100333_RS20020	COG1216	Glycosyl transferase, family 2
S100333_RS20025	COG0351	phosphomethylpyrimidine kinase
S100333_RS20035	COG1621	beta-fructofuranosidase activity
S100333_RS20040	COG1263	PTS System
S100333_RS20040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS20045	COG2116	formate transmembrane transporter activity
S100333_RS20050	COG3711	transcriptional antiterminator
S100333_RS20060	COG1404	Belongs to the peptidase S8 family
S100333_RS20065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_RS20070	COG0778	Nitroreductase
S100333_RS20075	COG0772	Belongs to the SEDS family
S100333_RS20090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S100333_RS20095	COG1845	cytochrome c oxidase, subunit III
S100333_RS20100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S100333_RS20110	COG2261	transglycosylase associated protein
S100333_RS20115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S100333_RS20120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S100333_RS20125	COG2246	polysaccharide biosynthetic process
S100333_RS20130	COG1309	transcriptional regulator
S100333_RS20140	COG3162	membrane
S100333_RS20145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S100333_RS20150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S100333_RS20155	COG2837	iron assimilation
S100333_RS20160	COG2822	iron ion transport
S100333_RS20165	COG0672	)-iron permease
S100333_RS20170	COG0352	thiamine-phosphate diphosphorylase activity
S100333_RS20175	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S100333_RS20180	COG0583	DNA-binding transcription factor activity
S100333_RS20185	COG1380	Effector of murein hydrolase LrgA
S100333_RS20190	COG1346	cytolysis
S100333_RS20195	COG2814	Major facilitator Superfamily
S100333_RS20200	COG4895	conserved protein (DUF2196)
S100333_RS20205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S100333_RS20210	COG0346	lactoylglutathione lyase activity
S100333_RS20220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_RS20230	COG1263	PTS System
S100333_RS20230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S100333_RS20235	COG3711	transcriptional antiterminator
S100333_RS20240	COG1442	glycosyl transferase family 8
S100333_RS20245	COG5522	Integral membrane protein (intg_mem_TP0381)
S100333_RS20250	COG1846	Transcriptional regulator
S100333_RS20255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S100333_RS20260	COG2234	aminopeptidase activity
S100333_RS20265	COG2357	RelA SpoT domain protein
S100333_RS20275	COG1575	Belongs to the MenA family. Type 1 subfamily
S100333_RS20290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S100333_RS20295	COG1696	Membrane protein involved in D-alanine export
S100333_RS20300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S100333_RS20305	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S100333_RS20315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S100333_RS20320	COG1486	melibiose metabolic process
S100333_RS20325	COG1447	Phosphotransferase system cellobiose-specific component IIA
S100333_RS20330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_RS20335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S100333_RS20340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S100333_RS20340	COG3711	transcriptional antiterminator
S100333_RS20350	COG2094	Belongs to the DNA glycosylase MPG family
S100333_RS20355	COG0753	catalase activity
S100333_RS20360	COG2814	Major facilitator Superfamily
S100333_RS20365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S100333_RS20370	COG1131	(ABC) transporter
S100333_RS20390	COG1595	DNA-templated transcription, initiation
S100333_RS20395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S100333_RS20400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S100333_RS20405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S100333_RS20410	COG4988	ABC transporter
S100333_RS20415	COG1294	oxidase, subunit
S100333_RS20420	COG1271	oxidase subunit
S100333_RS20425	COG3493	citrate carrier protein
S100333_RS20430	COG0501	Belongs to the peptidase M48B family
S100333_RS20440	COG0726	polysaccharide deacetylase
S100333_RS20445	COG3842	ATPase activity
S100333_RS20450	COG2508	Transcriptional regulator
S100333_RS20455	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS20460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S100333_RS20470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S100333_RS20480	COG4585	Histidine kinase
S100333_RS20485	COG2197	response regulator
S100333_RS20490	COG2195	Cleaves the N-terminal amino acid of tripeptides
S100333_RS20500	COG4894	glucomannan catabolic process
S100333_RS20505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_RS20510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S100333_RS20515	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS20520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S100333_RS20525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S100333_RS20530	COG2610	gluconate transmembrane transporter activity
S100333_RS20535	COG0500	methyltransferase
S100333_RS20540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_RS20555	COG0753	catalase activity
S100333_RS20555	COG0693	protein deglycase activity
S100333_RS20560	COG2851	Citrate transporter
S100333_RS20565	COG2273	Hydrolase Family 16
S100333_RS20570	COG3711	transcriptional antiterminator
S100333_RS20585	COG2270	Major facilitator Superfamily
S100333_RS20590	COG0513	Belongs to the DEAD box helicase family
S100333_RS20595	COG2755	lipolytic protein G-D-S-L family
S100333_RS20595	COG3401	FG-GAP repeat protein
S100333_RS20680	COG3209	COG3209 Rhs family protein
S100333_RS20710	COG0589	response to stress
S100333_RS20730	COG5444	nuclease activity
S100333_RS20740	COG5444	nuclease activity
S100333_RS20755	COG3507	Belongs to the glycosyl hydrolase 43 family
S100333_RS20765	COG0833	amino acid
S100333_RS20770	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S100333_RS20775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S100333_RS20780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S100333_RS20785	COG2390	Transcriptional regulator
S100333_RS20795	COG3192	ethanolamine utilization protein
S100333_RS20800	COG2079	MmgE PrpD family protein
S100333_RS20805	COG1473	amidohydrolase
S100333_RS20810	COG1126	abc transporter atp-binding protein
S100333_RS20815	COG0765	amino acid transport
S100333_RS20820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S100333_RS20825	COG0456	acetyltransferase
S100333_RS20830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S100333_RS20835	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S100333_RS20840	COG0561	phosphatase activity
S100333_RS20870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S100333_RS20875	COG5294	Protein conserved in bacteria
S100333_RS20880	COG0577	efflux transmembrane transporter activity
S100333_RS20885	COG1136	(ABC) transporter
S100333_RS20890	COG2205	protein histidine kinase activity
S100333_RS20895	COG0745	RESPONSE REGULATOR receiver
S100333_RS20900	COG0191	fructose-bisphosphate aldolase activity
S100333_RS20905	COG1082	Xylose isomerase domain protein TIM barrel
S100333_RS20910	COG1082	Xylose isomerase domain protein TIM barrel
S100333_RS20915	COG0673	inositol 2-dehydrogenase activity
S100333_RS20920	COG2814	Major facilitator Superfamily
S100333_RS20925	COG1082	Xylose isomerase domain protein TIM barrel
S100333_RS20930	COG3962	Belongs to the TPP enzyme family
S100333_RS20935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S100333_RS20945	COG1012	belongs to the aldehyde dehydrogenase family
S100333_RS20950	COG1349	DNA-binding transcription factor activity
S100333_RS20955	COG0667	Aldo Keto reductase
S100333_RS20975	COG0326	Molecular chaperone. Has ATPase activity
S100333_RS21030	COG3328	transposase activity
S100333_RS21040	COG1917	Cupin 2, conserved barrel domain protein
S100333_RS21045	COG1309	transcriptional regulator
S100333_RS21050	COG1028	Short-chain dehydrogenase reductase Sdr
S100333_RS21060	COG1846	Transcriptional regulator
S100333_RS21065	COG1380	Effector of murein hydrolase LrgA
S100333_RS21070	COG1346	cytolysis
S100333_RS21075	COG5039	Polysaccharide pyruvyl transferase
S100333_RS21080	COG1929	Belongs to the glycerate kinase type-1 family
S100333_RS21085	COG1802	Transcriptional regulator
S100333_RS21090	COG1070	Carbohydrate kinase
S100333_RS21095	COG2610	gluconate transmembrane transporter activity
S100333_RS21100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S100333_RS21105	COG0450	alkyl hydroperoxide reductase
S100333_RS21110	COG3634	alkyl hydroperoxide reductase activity
S100333_RS21115	COG2723	6-phospho-beta-galactosidase activity
S100333_RS21120	COG2190	(PTS) system
S100333_RS21125	COG2188	Transcriptional regulator
S100333_RS21135	COG1131	(ABC) transporter
S100333_RS21140	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S100333_RS21155	COG0071	Belongs to the small heat shock protein (HSP20) family
S100333_RS21165	COG3773	Cell wall hydrolase
S100333_RS21190	COG0210	DNA helicase
S100333_RS21235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S100333_RS21250	COG1063	alcohol dehydrogenase
S100333_RS21270	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S100333_RS21275	COG0456	acetyltransferase
S100333_RS21290	COG0010	Belongs to the arginase family
S100333_RS21295	COG0833	amino acid
S100333_RS21300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S100333_RS21320	COG5658	integral membrane protein
S100333_RS21325	COG0640	Transcriptional regulator
S100333_RS21335	COG5002	protein histidine kinase activity
S100333_RS21340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S100333_RS21345	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S100333_RS21350	COG4853	Protein conserved in bacteria
S100333_RS21355	COG4863	YycH protein
S100333_RS21360	COG5002	protein histidine kinase activity
S100333_RS21365	COG0745	RESPONSE REGULATOR receiver
S100333_RS21395	COG0346	lactoylglutathione lyase activity
S100333_RS21400	COG0305	Participates in initiation and elongation during chromosome replication
S100333_RS21415	COG3093	addiction module antidote protein HigA
S100333_RS21420	COG2807	transmembrane transport
S100333_RS21425	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S100333_RS21430	COG0359	binds to the 23S rRNA
S100333_RS21435	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S100333_RS21455	COG1733	regulation of RNA biosynthetic process
S100333_RS21460	COG1227	inorganic diphosphatase activity
S100333_RS21475	COG2271	Major facilitator Superfamily
S100333_RS21480	COG0789	Transcriptional regulator
S100333_RS21480	COG4978	Transcriptional regulator
S100333_RS21490	COG4319	ketosteroid isomerase
S100333_RS21495	COG1357	PFAM Pentapeptide repeats (8 copies)
S100333_RS21500	COG2814	Major facilitator Superfamily
S100333_RS21510	COG1846	Transcriptional regulator
S100333_RS21515	COG2153	protein acetylation
S100333_RS21520	COG2364	Membrane
S100333_RS21525	COG0456	acetyltransferase
S100333_RS21530	COG2315	Protein conserved in bacteria
S100333_RS21535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S100333_RS21540	COG1331	Highly conserved protein containing a thioredoxin domain
S100333_RS21545	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
S100333_RS21550	COG1331	Highly conserved protein containing a thioredoxin domain
S100333_RS21555	COG1266	CAAX protease self-immunity
S100333_RS21560	COG2814	Major facilitator Superfamily
S100333_RS21560	COG0477	Major facilitator Superfamily
S100333_RS21565	COG0346	lactoylglutathione lyase activity
S100333_RS21570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S100333_RS21575	COG0542	response to heat
S100333_RS21585	COG1609	Transcriptional regulator
S100333_RS21590	COG0708	Exodeoxyribonuclease III
S100333_RS21595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S100333_RS21600	COG0629	single-stranded DNA binding
S100333_RS21605	COG0360	Binds together with S18 to 16S ribosomal RNA
S100333_RS21610	COG0012	GTP binding
S100333_RS21615	COG0243	molybdopterin cofactor binding
S100333_RS21620	COG4481	Protein conserved in bacteria
S100333_RS21625	COG3949	Membrane
S100333_RS21635	COG1475	DNA binding
S100333_RS21640	COG1192	Involved in chromosome partitioning
S100333_RS21650	COG1475	DNA binding
S100333_RS21655	COG0357	Ribosomal RNA small subunit methyltransferase G
S100333_RS21660	COG0445	tRNA wobble uridine modification
S100333_RS21665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S100333_RS21670	COG1847	R3H domain protein
S100333_RS21675	COG0706	membrane insertase activity
S100333_RS21680	COG0594	ribonuclease P activity
S100333_RS21745	COG0457	Tetratricopeptide repeat
S100333_RS21885	COG3883	PFAM NLP P60 protein
S100333_RS21885	COG0791	NLP P60 protein
S100333_RS21940	COG0629	single-stranded DNA binding
S100333_RS21955	COG0582	viral genome integration into host DNA
S100333_RS21985	COG1793	dna ligase
S100333_RS22000	COG1525	nuclease
S100333_RS22110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII