locus-tag	class	description
S101392_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
S101392_RS00010	COG0592	DNA-directed DNA polymerase activity
S101392_RS00015	COG2501	S4 domain
S101392_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101392_RS00030	COG0187	DNA topoisomerase II activity
S101392_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101392_RS00070	COG0516	GMP reductase activity
S101392_RS00070	COG0517	IMP dehydrogenase activity
S101392_RS00075	COG1686	Belongs to the peptidase S11 family
S101392_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
S101392_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
S101392_RS00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
S101392_RS00105	COG1428	Deoxynucleoside kinase
S101392_RS00110	COG1428	Deoxynucleoside kinase
S101392_RS00115	COG1388	LysM domain
S101392_RS00115	COG3858	chitin binding
S101392_RS00120	COG1335	isochorismatase
S101392_RS00125	COG0590	tRNA wobble adenosine to inosine editing
S101392_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
S101392_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
S101392_RS00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
S101392_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
S101392_RS00195	COG3853	Toxic anion resistance protein (TelA)
S101392_RS00200	COG1982	Orn Lys Arg decarboxylase major
S101392_RS00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
S101392_RS00210	COG3870	Protein conserved in bacteria
S101392_RS00215	COG1728	Protein conserved in bacteria
S101392_RS00220	COG0470	DNA polymerase III
S101392_RS00225	COG1774	PSP1 C-terminal conserved region
S101392_RS00230	COG4467	Involved in initiation control of chromosome replication
S101392_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
S101392_RS00240	COG2827	Endonuclease containing a URI domain
S101392_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
S101392_RS00250	COG2002	toxin-antitoxin pair type II binding
S101392_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101392_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101392_RS00260	COG0084	hydrolase, TatD family'
S101392_RS00265	COG3584	3D domain protein
S101392_RS00265	COG3583	domain protein
S101392_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101392_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
S101392_RS00285	COG4466	Protein conserved in bacteria
S101392_RS00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
S101392_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101392_RS00305	COG0251	oxidation-reduction process
S101392_RS00310	COG2088	sporulation resulting in formation of a cellular spore
S101392_RS00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
S101392_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
S101392_RS00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
S101392_RS00330	COG0193	aminoacyl-tRNA hydrolase activity
S101392_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
S101392_RS00345	COG2002	toxin-antitoxin pair type II binding
S101392_RS00350	COG2244	polysaccharide biosynthetic process
S101392_RS00355	COG3956	TIGRFAM MazG family protein
S101392_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
S101392_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
S101392_RS00380	COG1098	S1 RNA binding domain
S101392_RS00395	COG2208	phosphoserine phosphatase activity
S101392_RS00400	COG2304	oxidoreductase activity
S101392_RS00405	COG0515	serine threonine protein kinase
S101392_RS00410	COG0037	tRNA processing
S101392_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
S101392_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101392_RS00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
S101392_RS00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
S101392_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101392_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101392_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101392_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
S101392_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101392_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
S101392_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
S101392_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
S101392_RS00475	COG1396	sequence-specific DNA binding
S101392_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101392_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
S101392_RS00565	COG4463	regulation of RNA biosynthetic process
S101392_RS00570	COG3880	PFAM UvrB UvrC protein
S101392_RS00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
S101392_RS00580	COG0542	response to heat
S101392_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
S101392_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
S101392_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
S101392_RS00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
S101392_RS00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
S101392_RS00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
S101392_RS00620	COG1045	serine acetyltransferase
S101392_RS00625	COG0215	cysteine-tRNA ligase activity
S101392_RS00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
S101392_RS00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101392_RS00640	COG3688	RNA-binding protein containing a PIN domain
S101392_RS00645	COG1595	DNA-templated transcription, initiation
S101392_RS00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101392_RS00660	COG0250	Participates in transcription elongation, termination and antitermination
S101392_RS00670	COG0081	regulation of translation
S101392_RS00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
S101392_RS00685	COG2813	Specifically methylates the guanine in position
S101392_RS00690	COG0085	RNA polymerase activity
S101392_RS00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
S101392_RS00700	COG1358	cellular component organization or biogenesis
S101392_RS00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
S101392_RS00710	COG0049	tRNA binding
S101392_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
S101392_RS00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
S101392_RS00725	COG0596	Alpha beta hydrolase
S101392_RS00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
S101392_RS00740	COG0088	Forms part of the polypeptide exit tunnel
S101392_RS00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
S101392_RS00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
S101392_RS00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
S101392_RS00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
S101392_RS00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
S101392_RS00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
S101392_RS00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
S101392_RS00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
S101392_RS00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
S101392_RS00830	COG0200	Binds to the 23S rRNA
S101392_RS00835	COG0201	protein transport
S101392_RS00840	COG0563	adenylate kinase activity
S101392_RS00845	COG0024	Methionine aminopeptidase
S101392_RS00850	COG2163	COG2163 Ribosomal protein L14E L6E L27E
S101392_RS00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
S101392_RS00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
S101392_RS00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
S101392_RS00875	COG0202	RNA polymerase activity
S101392_RS00880	COG0203	ribosomal protein L17
S101392_RS00885	COG1122	ATPase activity
S101392_RS00890	COG1122	ATPase activity
S101392_RS00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101392_RS00900	COG0101	tRNA pseudouridine synthase activity
S101392_RS00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
S101392_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
S101392_RS00915	COG2226	methyltransferase
S101392_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS00930	COG0489	protein tyrosine kinase activity
S101392_RS00940	COG2194	sulfuric ester hydrolase activity
S101392_RS00945	COG0726	polysaccharide deacetylase
S101392_RS00990	COG1395	domain, Protein
S101392_RS01080	COG5444	nuclease activity
S101392_RS01155	COG0659	secondary active sulfate transmembrane transporter activity
S101392_RS01160	COG0385	Bile acid
S101392_RS01165	COG2819	hydrolase of the alpha beta superfamily
S101392_RS01170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS01180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS01185	COG2207	Transcriptional regulator
S101392_RS01185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS01190	COG3876	Protein conserved in bacteria
S101392_RS01195	COG1472	Belongs to the glycosyl hydrolase 3 family
S101392_RS01200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101392_RS01205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS01205	COG1263	PTS System
S101392_RS01210	COG1737	Transcriptional regulator
S101392_RS01215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
S101392_RS01220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS01225	COG1683	Conserved Protein
S101392_RS01255	COG1595	DNA-templated transcription, initiation
S101392_RS01260	COG5662	AntiSigma factor
S101392_RS01265	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101392_RS01270	COG4856	YbbR-like protein
S101392_RS01275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101392_RS01280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
S101392_RS01290	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S101392_RS01295	COG2169	Transcriptional regulator
S101392_RS01300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101392_RS01305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101392_RS01310	COG3002	Belongs to the UPF0753 family
S101392_RS01315	COG0288	reversible hydration of carbon dioxide
S101392_RS01325	COG5609	conserved protein (DUF2294)
S101392_RS01330	COG0640	Transcriptional regulator
S101392_RS01335	COG2814	Major facilitator Superfamily
S101392_RS01350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
S101392_RS01355	COG0210	DNA helicase
S101392_RS01365	COG0596	Alpha beta hydrolase
S101392_RS01370	COG0745	RESPONSE REGULATOR receiver
S101392_RS01375	COG0642	Histidine kinase
S101392_RS01385	COG0515	serine threonine protein kinase
S101392_RS01400	COG1113	amino acid transport
S101392_RS01415	COG2602	Beta-lactamase
S101392_RS01420	COG2124	cytochrome p450
S101392_RS01430	COG0531	amino acid
S101392_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
S101392_RS01440	COG2271	Major facilitator Superfamily
S101392_RS01455	COG1846	Transcriptional regulator
S101392_RS01455	COG0456	acetyltransferase
S101392_RS01460	COG2271	Major facilitator Superfamily
S101392_RS01465	COG0697	spore germination
S101392_RS01470	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS01470	COG2207	Transcriptional regulator
S101392_RS01475	COG1397	ADP-ribosylglycohydrolase
S101392_RS01480	COG5444	nuclease activity
S101392_RS01485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
S101392_RS01490	COG3591	Belongs to the peptidase S1B family
S101392_RS01500	COG0596	Alpha beta hydrolase
S101392_RS01505	COG1183	phosphatidylcholine synthase activity
S101392_RS01510	COG0586	Pfam SNARE associated Golgi protein
S101392_RS01515	COG0688	phosphatidylethanolamine metabolic process
S101392_RS01525	COG1054	Belongs to the UPF0176 family
S101392_RS01530	COG1301	dicarboxylic acid transport
S101392_RS01535	COG2190	(PTS) system
S101392_RS01535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS01535	COG1263	PTS System
S101392_RS01540	COG0363	glucosamine-6-phosphate deaminase activity
S101392_RS01545	COG2188	Transcriptional regulator
S101392_RS01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101392_RS01560	COG0833	amino acid
S101392_RS01565	COG2040	homocysteine
S101392_RS01575	COG1115	amino acid carrier protein
S101392_RS01580	COG2066	Belongs to the glutaminase family
S101392_RS01585	COG4191	Histidine kinase
S101392_RS01590	COG0784	Response regulator, receiver
S101392_RS01595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101392_RS01600	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS01605	COG2271	Major facilitator Superfamily
S101392_RS01610	COG4948	Mandelate Racemase Muconate Lactonizing
S101392_RS01615	COG2186	Transcriptional regulator
S101392_RS01620	COG2721	sulfolactate sulfo-lyase activity
S101392_RS01625	COG3173	Aminoglycoside phosphotransferase
S101392_RS01635	COG0697	spore germination
S101392_RS01640	COG0745	RESPONSE REGULATOR receiver
S101392_RS01645	COG2205	protein histidine kinase activity
S101392_RS01650	COG1131	(ABC) transporter
S101392_RS01665	COG3773	Cell wall hydrolase
S101392_RS01670	COG2304	oxidoreductase activity
S101392_RS01680	COG3540	Alkaline phosphatase
S101392_RS01685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101392_RS01690	COG0805	protein transport
S101392_RS01695	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
S101392_RS01700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101392_RS01705	COG0477	Major facilitator Superfamily
S101392_RS01710	COG1309	transcriptional regulator
S101392_RS01715	COG0252	asparaginase activity
S101392_RS01720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101392_RS01725	COG1714	RDD family
S101392_RS01730	COG1405	negative regulation of cell septum assembly
S101392_RS01730	COG3012	SEC-C Motif Domain Protein
S101392_RS01735	COG3290	protein histidine kinase activity
S101392_RS01740	COG3279	Response regulator of the LytR AlgR family
S101392_RS01745	COG4555	ABC transporter
S101392_RS01750	COG1668	transmembrane transport
S101392_RS01755	COG0667	Aldo Keto reductase
S101392_RS01765	COG1595	DNA-templated transcription, initiation
S101392_RS01775	COG1595	DNA-templated transcription, initiation
S101392_RS01780	COG1876	peptidase activity
S101392_RS01785	COG0457	Tetratricopeptide repeat
S101392_RS01790	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS01795	COG0366	Alpha amylase catalytic
S101392_RS01800	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101392_RS01805	COG1121	(ABC) transporter
S101392_RS01810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101392_RS01815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS01820	COG2310	stress, protein
S101392_RS01825	COG2310	stress, protein
S101392_RS01830	COG2310	stress, protein
S101392_RS01835	COG0861	Integral membrane protein TerC family
S101392_RS01845	COG3853	Toxic anion resistance protein (TelA)
S101392_RS01850	COG0477	Major facilitator Superfamily
S101392_RS01855	COG2814	Major facilitator Superfamily
S101392_RS01860	COG0640	Transcriptional regulator
S101392_RS01865	COG0517	IMP dehydrogenase activity
S101392_RS01865	COG4175	Glycine betaine
S101392_RS01870	COG4176	ABC-type proline glycine betaine transport system permease component
S101392_RS01875	COG2113	Glycine betaine
S101392_RS01880	COG1473	amidohydrolase
S101392_RS01885	COG1288	antiporter activity
S101392_RS01895	COG0366	Alpha amylase catalytic
S101392_RS01900	COG0039	L-malate dehydrogenase activity
S101392_RS01905	COG1620	l-lactate permease
S101392_RS01910	COG2814	Major facilitator Superfamily
S101392_RS01915	COG1846	Transcriptional regulator
S101392_RS01920	COG1280	lysine exporter protein (LysE YggA)
S101392_RS01925	COG3403	YqcI/YcgG family
S101392_RS01930	COG1113	amino acid transport
S101392_RS01935	COG3665	Urea carboxylase-associated protein
S101392_RS01940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
S101392_RS01945	COG1660	Displays ATPase and GTPase activities
S101392_RS01950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
S101392_RS01955	COG2226	methyltransferase
S101392_RS01960	COG0583	DNA-binding transcription factor activity
S101392_RS01965	COG3458	cephalosporin-C deacetylase activity
S101392_RS01970	COG3541	Predicted nucleotidyltransferase
S101392_RS01975	COG0506	proline dehydrogenase activity
S101392_RS01980	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS01985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101392_RS01990	COG2508	Transcriptional regulator
S101392_RS01995	COG3689	TIGRFAM TIGR03943 family protein
S101392_RS02000	COG0701	Predicted permease
S101392_RS02005	COG2267	carboxylic ester hydrolase activity
S101392_RS02010	COG0492	ferredoxin-NADP+ reductase activity
S101392_RS02015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101392_RS02015	COG1587	Uroporphyrinogen-III synthase
S101392_RS02020	COG2146	nitrite reductase [NAD(P)H] activity
S101392_RS02025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101392_RS02030	COG0243	molybdopterin cofactor binding
S101392_RS02035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101392_RS02040	COG2223	nitrite transmembrane transporter activity
S101392_RS02045	COG1469	GTP cyclohydrolase I activity
S101392_RS02050	COG1376	ErfK ybiS ycfS ynhG family protein
S101392_RS02060	COG0523	cobalamin synthesis protein
S101392_RS02065	COG0765	amino acid transport
S101392_RS02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS02075	COG1714	RDD family
S101392_RS02085	COG2723	6-phospho-beta-galactosidase activity
S101392_RS02095	COG3209	COG3209 Rhs family protein
S101392_RS02100	COG3290	protein histidine kinase activity
S101392_RS02100	COG0840	transmembrane signaling receptor activity
S101392_RS02105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
S101392_RS02110	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
S101392_RS02115	COG1733	regulation of RNA biosynthetic process
S101392_RS02130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS02145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
S101392_RS02150	COG2814	Major facilitator Superfamily
S101392_RS02160	COG0697	spore germination
S101392_RS02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS02175	COG2364	Membrane
S101392_RS02180	COG1126	abc transporter atp-binding protein
S101392_RS02185	COG0765	amino acid transport
S101392_RS02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS02195	COG0583	DNA-binding transcription factor activity
S101392_RS02200	COG0163	prenyltransferase activity
S101392_RS02205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
S101392_RS02220	COG0596	Alpha beta hydrolase
S101392_RS02225	COG3104	oligopeptide transport
S101392_RS02230	COG5434	Belongs to the glycosyl hydrolase 28 family
S101392_RS02240	COG0697	spore germination
S101392_RS02250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101392_RS02255	COG1136	(ABC) transporter
S101392_RS02260	COG0577	efflux transmembrane transporter activity
S101392_RS02265	COG0745	RESPONSE REGULATOR receiver
S101392_RS02270	COG5002	protein histidine kinase activity
S101392_RS02270	COG3850	Histidine kinase
S101392_RS02275	COG0457	Tetratricopeptide repeat
S101392_RS02295	COG0527	aspartate kinase activity
S101392_RS02300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS02305	COG4605	iron ion homeostasis
S101392_RS02310	COG4604	ABC transporter, ATP-binding protein
S101392_RS02315	COG4607	ABC-type enterochelin transport system periplasmic component
S101392_RS02320	COG2814	Major facilitator Superfamily
S101392_RS02325	COG1309	transcriptional regulator
S101392_RS02330	COG0778	Nitroreductase
S101392_RS02335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101392_RS02340	COG0640	Transcriptional regulator
S101392_RS02345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS02350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
S101392_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS02360	COG4975	Glucose uptake
S101392_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS02370	COG4549	nuclear export factor GLE1
S101392_RS02375	COG2372	response to copper ion
S101392_RS02375	COG1276	copper resistance
S101392_RS02380	COG1349	DNA-binding transcription factor activity
S101392_RS02390	COG2213	PTS system mannitol-specific
S101392_RS02395	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS02400	COG0246	Mannitol dehydrogenase
S101392_RS02405	COG0473	3-isopropylmalate dehydrogenase activity
S101392_RS02410	COG0681	Belongs to the peptidase S26 family
S101392_RS02415	COG0412	Dienelactone hydrolase
S101392_RS02420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101392_RS02430	COG0561	phosphatase activity
S101392_RS02435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
S101392_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
S101392_RS02445	COG4336	lyase activity
S101392_RS02450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
S101392_RS02455	COG1984	allophanate hydrolase subunit 2
S101392_RS02460	COG1414	Transcriptional regulator
S101392_RS02465	COG2755	lipolytic protein G-D-S-L family
S101392_RS02475	COG2329	Antibiotic biosynthesis monooxygenase
S101392_RS02480	COG0768	penicillin binding
S101392_RS02485	COG4989	oxidoreductase activity
S101392_RS02490	COG3711	transcriptional antiterminator
S101392_RS02495	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS02500	COG2226	methyltransferase
S101392_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS02510	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS02515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS02520	COG3871	stress protein (general stress protein 26)
S101392_RS02530	COG2814	Major facilitator Superfamily
S101392_RS02535	COG1522	sequence-specific DNA binding
S101392_RS02540	COG0551	DNA topoisomerase type I activity
S101392_RS02540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101392_RS02545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
S101392_RS02550	COG3706	GGDEF domain
S101392_RS02555	COG5298	Protein conserved in bacteria
S101392_RS02560	COG1215	transferase activity, transferring glycosyl groups
S101392_RS02570	COG0531	amino acid
S101392_RS02580	COG0028	Belongs to the TPP enzyme family
S101392_RS02590	COG1914	H( )-stimulated, divalent metal cation uptake system
S101392_RS02595	COG2261	transglycosylase associated protein
S101392_RS02600	COG4876	unkown
S101392_RS02605	COG2217	Heavy metal translocating P-type atpase
S101392_RS02610	COG3729	General stress protein
S101392_RS02615	COG0662	Cupin 2, conserved barrel domain protein
S101392_RS02620	COG2329	Antibiotic biosynthesis monooxygenase
S101392_RS02625	COG3546	catalase activity
S101392_RS02630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
S101392_RS02635	COG3290	protein histidine kinase activity
S101392_RS02640	COG4565	transcriptional regulatory protein
S101392_RS02645	COG1301	dicarboxylic acid transport
S101392_RS02650	COG0628	permease
S101392_RS02655	COG1131	(ABC) transporter
S101392_RS02660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101392_RS02670	COG1960	acyl-CoA dehydrogenase activity
S101392_RS02685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101392_RS02690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS02695	COG1181	Belongs to the D-alanine--D-alanine ligase family
S101392_RS02700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
S101392_RS02710	COG0513	Belongs to the DEAD box helicase family
S101392_RS02715	COG3402	PFAM membrane-flanked domain
S101392_RS02720	COG3428	Bacterial PH domain
S101392_RS02725	COG0705	Rhomboid family
S101392_RS02730	COG0736	holo-[acyl-carrier-protein] synthase activity
S101392_RS02735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
S101392_RS02740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101392_RS02745	COG0864	Transcriptional regulator
S101392_RS02750	COG2337	Toxic component of a toxin-antitoxin (TA) module
S101392_RS02755	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS02760	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS02765	COG2172	sigma factor antagonist activity
S101392_RS02770	COG2208	phosphoserine phosphatase activity
S101392_RS02775	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS02780	COG2172	sigma factor antagonist activity
S101392_RS02785	COG1191	sigma factor activity
S101392_RS02790	COG2208	phosphoserine phosphatase activity
S101392_RS02795	COG2183	response to ionizing radiation
S101392_RS02805	COG3091	SprT-like family
S101392_RS02850	COG0515	serine threonine protein kinase
S101392_RS02855	COG0515	serine threonine protein kinase
S101392_RS02860	COG1132	(ABC) transporter
S101392_RS02880	COG1476	TRANSCRIPTIONal
S101392_RS02895	COG1278	Cold shock
S101392_RS02900	COG1329	Transcriptional regulator
S101392_RS02910	COG0697	spore germination
S101392_RS02915	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS02915	COG2207	Transcriptional regulator
S101392_RS02920	COG0697	spore germination
S101392_RS02925	COG2207	Transcriptional regulator
S101392_RS02925	COG3708	Transcriptional regulator
S101392_RS02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS02935	COG0477	Major facilitator Superfamily
S101392_RS02945	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
S101392_RS02960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS02965	COG1309	transcriptional regulator
S101392_RS02970	COG0697	spore germination
S101392_RS02975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS02980	COG2030	dehydratase
S101392_RS02985	COG3545	Serine hydrolase
S101392_RS02990	COG1733	regulation of RNA biosynthetic process
S101392_RS02995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS03000	COG2814	Major facilitator Superfamily
S101392_RS03005	COG1309	transcriptional regulator
S101392_RS03010	COG0640	Transcriptional regulator
S101392_RS03015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101392_RS03030	COG0697	spore germination
S101392_RS03035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS03040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101392_RS03045	COG0640	Transcriptional regulator
S101392_RS03050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101392_RS03065	COG4585	Histidine kinase
S101392_RS03070	COG2197	response regulator
S101392_RS03075	COG2409	Drug exporters of the RND superfamily
S101392_RS03080	COG0596	Alpha beta hydrolase
S101392_RS03085	COG1811	Na channel or pump
S101392_RS03090	COG4978	Transcriptional regulator
S101392_RS03090	COG0789	Transcriptional regulator
S101392_RS03095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101392_RS03100	COG0778	Nitroreductase
S101392_RS03105	COG0346	lactoylglutathione lyase activity
S101392_RS03110	COG2259	Doxx family
S101392_RS03115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS03130	COG2323	membrane
S101392_RS03135	COG2323	membrane
S101392_RS03140	COG0071	Belongs to the small heat shock protein (HSP20) family
S101392_RS03155	COG1309	transcriptional regulator
S101392_RS03165	COG0456	acetyltransferase
S101392_RS03170	COG0488	(ABC) transporter
S101392_RS03175	COG1113	amino acid transport
S101392_RS03180	COG2318	DinB family
S101392_RS03185	COG1846	Transcriptional regulator
S101392_RS03190	COG1033	growth of symbiont in host cell
S101392_RS03190	COG2409	Drug exporters of the RND superfamily
S101392_RS03195	COG0778	Nitroreductase
S101392_RS03200	COG1846	Transcriptional regulator
S101392_RS03205	COG2814	Major facilitator Superfamily
S101392_RS03210	COG0730	response to heat
S101392_RS03215	COG1802	Transcriptional regulator
S101392_RS03220	COG3858	chitin binding
S101392_RS03220	COG1388	LysM domain
S101392_RS03225	COG1819	glycosyl
S101392_RS03235	COG1785	Belongs to the alkaline phosphatase family
S101392_RS03240	COG5646	InterPro IPR014922
S101392_RS03250	COG0454	-acetyltransferase
S101392_RS03255	COG1078	dGTPase activity
S101392_RS03260	COG1388	LysM domain
S101392_RS03265	COG2814	Major facilitator Superfamily
S101392_RS03270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101392_RS03275	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101392_RS03280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101392_RS03285	COG2723	6-phospho-beta-galactosidase activity
S101392_RS03290	COG2188	Transcriptional regulator
S101392_RS03295	COG1940	carbohydrate kinase activity
S101392_RS03300	COG1482	cell wall glycoprotein biosynthetic process
S101392_RS03305	COG4124	Belongs to the glycosyl hydrolase 26 family
S101392_RS03350	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
S101392_RS03355	COG0802	atpase or kinase
S101392_RS03360	COG1214	PFAM Peptidase M22, glycoprotease
S101392_RS03365	COG0456	acetyltransferase
S101392_RS03370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
S101392_RS03375	COG0488	(ABC) transporter
S101392_RS03380	COG0315	cyclic pyranopterin monophosphate synthase activity
S101392_RS03385	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
S101392_RS03390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101392_RS03395	COG0805	protein transport
S101392_RS03410	COG1266	CAAX protease self-immunity
S101392_RS03420	COG0459	protein refolding
S101392_RS03430	COG1073	alpha beta
S101392_RS03435	COG0457	Tetratricopeptide repeat
S101392_RS03440	COG1063	alcohol dehydrogenase
S101392_RS03445	COG2211	Major facilitator Superfamily
S101392_RS03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101392_RS03455	COG1842	Phage shock protein A
S101392_RS03460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101392_RS03465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
S101392_RS03470	COG4260	virion core protein, lumpy skin disease virus
S101392_RS03480	COG2814	Major facilitator Superfamily
S101392_RS03485	COG1063	alcohol dehydrogenase
S101392_RS03490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
S101392_RS03495	COG0823	Involved in the tonB-independent uptake of proteins
S101392_RS03510	COG2267	carboxylic ester hydrolase activity
S101392_RS03520	COG2132	Multicopper oxidase
S101392_RS03525	COG1113	amino acid transport
S101392_RS03535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
S101392_RS03540	COG0714	Associated with various cellular activities
S101392_RS03545	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
S101392_RS03550	COG1305	Transglutaminase-like
S101392_RS03555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
S101392_RS03555	COG0519	Catalyzes the synthesis of GMP from XMP
S101392_RS03570	COG2252	PERMEase
S101392_RS03575	COG3064	Membrane
S101392_RS03585	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
S101392_RS03595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
S101392_RS03600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
S101392_RS03605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
S101392_RS03610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
S101392_RS03615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101392_RS03620	COG0047	phosphoribosylformylglycinamidine synthase activity
S101392_RS03625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
S101392_RS03630	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
S101392_RS03635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
S101392_RS03640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
S101392_RS03645	COG0138	bifunctional purine biosynthesis protein purh
S101392_RS03650	COG0151	Belongs to the GarS family
S101392_RS03655	COG1522	sequence-specific DNA binding
S101392_RS03660	COG0531	amino acid
S101392_RS03670	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101392_RS03675	COG1470	cell adhesion involved in biofilm formation
S101392_RS03680	COG4496	protein, YerC YecD
S101392_RS03685	COG0069	glutamate synthase activity
S101392_RS03690	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
S101392_RS03695	COG0210	DNA helicase
S101392_RS03700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
S101392_RS03705	COG4851	CamS sex pheromone cAM373 precursor
S101392_RS03710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101392_RS03715	COG1285	pathogenesis
S101392_RS03720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101392_RS03725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101392_RS03730	COG0154	amidase activity
S101392_RS03735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
S101392_RS03740	COG1309	transcriptional regulator
S101392_RS03745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
S101392_RS03750	COG1597	lipid kinase activity
S101392_RS03755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101392_RS03780	COG5444	nuclease activity
S101392_RS03790	COG3586	endonuclease activity
S101392_RS03800	COG0457	Tetratricopeptide repeat
S101392_RS03810	COG0217	transcriptional regulatory protein
S101392_RS03820	COG1309	transcriptional regulator
S101392_RS03825	COG3631	Ketosteroid isomerase-related protein
S101392_RS03845	COG3546	catalase activity
S101392_RS03850	COG0454	-acetyltransferase
S101392_RS03860	COG5578	integral membrane protein
S101392_RS03865	COG2972	Histidine kinase
S101392_RS03870	COG4753	response regulator
S101392_RS03870	COG2207	Transcriptional regulator
S101392_RS03875	COG1653	transport
S101392_RS03880	COG1175	transmembrane transport
S101392_RS03885	COG0395	ABC-type sugar transport system, permease component
S101392_RS03890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101392_RS03895	COG2207	Transcriptional regulator
S101392_RS03900	COG2755	lipolytic protein G-D-S-L family
S101392_RS03910	COG5578	integral membrane protein
S101392_RS03915	COG3401	FG-GAP repeat protein
S101392_RS03920	COG3401	FG-GAP repeat protein
S101392_RS03925	COG2755	lipolytic protein G-D-S-L family
S101392_RS03930	COG1874	Beta-galactosidase
S101392_RS03940	COG1653	transport
S101392_RS03945	COG4209	transmembrane transport
S101392_RS03950	COG0395	ABC-type sugar transport system, permease component
S101392_RS03955	COG1486	melibiose metabolic process
S101392_RS03960	COG2323	membrane
S101392_RS03965	COG2329	Antibiotic biosynthesis monooxygenase
S101392_RS03970	COG0346	lactoylglutathione lyase activity
S101392_RS03985	COG5583	Uncharacterized small protein (DUF2292)
S101392_RS03990	COG0670	Belongs to the BI1 family
S101392_RS03995	COG0697	spore germination
S101392_RS04000	COG1846	Transcriptional regulator
S101392_RS04005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101392_RS04015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101392_RS04015	COG2124	cytochrome p450
S101392_RS04020	COG1368	sulfuric ester hydrolase activity
S101392_RS04025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
S101392_RS04030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101392_RS04035	COG1442	glycosyl transferase family 8
S101392_RS04040	COG1216	Glycosyl transferase, family 2
S101392_RS04045	COG1442	glycosyl transferase family 8
S101392_RS04050	COG2223	nitrite transmembrane transporter activity
S101392_RS04055	COG1011	Hydrolase
S101392_RS04060	COG0531	amino acid
S101392_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS04070	COG0840	transmembrane signaling receptor activity
S101392_RS04075	COG0488	(ABC) transporter
S101392_RS04085	COG0789	Transcriptional regulator
S101392_RS04090	COG2814	Major facilitator Superfamily
S101392_RS04100	COG0488	(ABC) transporter
S101392_RS04105	COG0513	Belongs to the DEAD box helicase family
S101392_RS04110	COG0456	acetyltransferase
S101392_RS04115	COG2130	NADP-dependent
S101392_RS04125	COG2211	Major facilitator Superfamily
S101392_RS04130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
S101392_RS04135	COG1120	ATPase activity
S101392_RS04140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS04145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS04150	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101392_RS04170	COG3866	Pectate lyase
S101392_RS04175	COG0471	metal ion transport
S101392_RS04180	COG3290	protein histidine kinase activity
S101392_RS04185	COG4565	transcriptional regulatory protein
S101392_RS04190	COG3181	Tripartite tricarboxylate transporter family receptor
S101392_RS04195	COG2851	Citrate transporter
S101392_RS04200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS04205	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
S101392_RS04210	COG1254	Belongs to the acylphosphatase family
S101392_RS04215	COG2258	MOSC domain
S101392_RS04235	COG0024	Methionine aminopeptidase
S101392_RS04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS04240	COG1263	PTS System
S101392_RS04245	COG1368	sulfuric ester hydrolase activity
S101392_RS04260	COG1115	amino acid carrier protein
S101392_RS04265	COG0531	amino acid
S101392_RS04280	COG0697	spore germination
S101392_RS04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS04285	COG1263	PTS System
S101392_RS04290	COG0366	Alpha amylase catalytic
S101392_RS04295	COG2188	Transcriptional regulator
S101392_RS04300	COG0778	Nitroreductase
S101392_RS04305	COG0737	Belongs to the 5'-nucleotidase family
S101392_RS04310	COG0693	protein deglycase activity
S101392_RS04315	COG2814	Major facilitator Superfamily
S101392_RS04320	COG4840	Belongs to the UPF0435 family
S101392_RS04325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101392_RS04330	COG4980	gas vesicle protein
S101392_RS04335	COG1295	ribonuclease BN
S101392_RS04340	COG0477	Major facilitator Superfamily
S101392_RS04345	COG0387	Pfam Sodium calcium exchanger
S101392_RS04355	COG0668	transmembrane transport
S101392_RS04360	COG0535	radical SAM domain protein
S101392_RS04370	COG0726	polysaccharide deacetylase
S101392_RS04375	COG2084	Dehydrogenase
S101392_RS04380	COG0598	Magnesium transport protein CorA
S101392_RS04385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
S101392_RS04390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
S101392_RS04405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
S101392_RS04410	COG4637	Psort location Cytoplasmic, score
S101392_RS04415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101392_RS04420	COG0022	dehydrogenase e1 component
S101392_RS04425	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101392_RS04435	COG3284	Transcriptional regulator
S101392_RS04445	COG1742	UPF0060 membrane protein
S101392_RS04465	COG4842	Belongs to the WXG100 family
S101392_RS04470	COG1486	melibiose metabolic process
S101392_RS04475	COG1737	Transcriptional regulator
S101392_RS04480	COG1263	PTS System
S101392_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS04485	COG1132	(ABC) transporter
S101392_RS04490	COG1132	(ABC) transporter
S101392_RS04495	COG2259	Doxx family
S101392_RS04500	COG2514	catechol 2,3-dioxygenase activity
S101392_RS04505	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS04505	COG4977	sequence-specific DNA binding
S101392_RS04510	COG2814	Major facilitator Superfamily
S101392_RS04515	COG1082	Xylose isomerase domain protein TIM barrel
S101392_RS04520	COG0673	inositol 2-dehydrogenase activity
S101392_RS04525	COG4585	Histidine kinase
S101392_RS04530	COG2197	response regulator
S101392_RS04535	COG1131	(ABC) transporter
S101392_RS04540	COG0842	Transport permease protein
S101392_RS04540	COG1511	domain protein
S101392_RS04545	COG0842	Transport permease protein
S101392_RS04550	COG1695	Transcriptional regulator
S101392_RS04555	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
S101392_RS04560	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
S101392_RS04565	COG1309	transcriptional regulator
S101392_RS04570	COG2814	Major facilitator Superfamily
S101392_RS04575	COG2318	DinB family
S101392_RS04580	COG2814	Major facilitator Superfamily
S101392_RS04585	COG1846	Transcriptional regulator
S101392_RS04590	COG0392	lysyltransferase activity
S101392_RS04590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
S101392_RS04595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS04600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS04605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS04610	COG0384	phenazine biosynthesis protein PhzF
S101392_RS04615	COG0778	Nitroreductase
S101392_RS04630	COG1090	epimerase
S101392_RS04635	COG2137	regulation of response to DNA damage stimulus
S101392_RS04645	COG2814	Major facilitator Superfamily
S101392_RS04660	COG3103	Sh3 type 3 domain protein
S101392_RS04665	COG5658	integral membrane protein
S101392_RS04670	COG0596	Alpha beta hydrolase
S101392_RS04675	COG0463	Glycosyl transferase, family 2
S101392_RS04680	COG4485	Bacterial membrane protein, YfhO
S101392_RS04685	COG1988	membrane-bound metal-dependent
S101392_RS04690	COG1194	a g-specific adenine glycosylase
S101392_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS04715	COG3557	Belongs to the UPF0374 family
S101392_RS04720	COG1132	(ABC) transporter
S101392_RS04725	COG4129	membrane
S101392_RS04730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101392_RS04735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
S101392_RS04740	COG0735	belongs to the Fur family
S101392_RS04850	COG4326	sporulation control protein
S101392_RS04860	COG5577	PFAM Coat F domain
S101392_RS04865	COG3340	Belongs to the peptidase S51 family
S101392_RS04870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
S101392_RS04875	COG0277	FAD linked oxidase domain protein
S101392_RS04885	COG0753	catalase activity
S101392_RS04890	COG1116	anion transmembrane transporter activity
S101392_RS04895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101392_RS04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101392_RS04905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS04915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
S101392_RS04925	COG1476	TRANSCRIPTIONal
S101392_RS04935	COG3382	B3 4 domain protein
S101392_RS04940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
S101392_RS04950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
S101392_RS04955	COG0789	Transcriptional regulator
S101392_RS04960	COG1664	Polymer-forming cytoskeletal
S101392_RS04965	COG1664	Polymer-forming cytoskeletal
S101392_RS04970	COG2766	serine protein kinase
S101392_RS04975	COG2718	Belongs to the UPF0229 family
S101392_RS04980	COG1846	Transcriptional regulator
S101392_RS04985	COG1566	PFAM secretion protein HlyD family protein
S101392_RS04990	COG2814	Major facilitator Superfamily
S101392_RS04995	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101392_RS05015	COG1725	Transcriptional regulator
S101392_RS05020	COG1131	(ABC) transporter
S101392_RS05025	COG1131	(ABC) transporter
S101392_RS05030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101392_RS05035	COG1278	Cold shock
S101392_RS05045	COG1464	Belongs to the NlpA lipoprotein family
S101392_RS05050	COG3706	GGDEF domain
S101392_RS05055	COG1823	symporter activity
S101392_RS05075	COG5577	PFAM Coat F domain
S101392_RS05080	COG1525	nuclease
S101392_RS05080	COG4085	toxin activity
S101392_RS05080	COG0737	Belongs to the 5'-nucleotidase family
S101392_RS05085	COG3764	Sortase (surface protein transpeptidase)
S101392_RS05090	COG0564	pseudouridine synthase activity
S101392_RS05100	COG0517	IMP dehydrogenase activity
S101392_RS05105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101392_RS05110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101392_RS05110	COG3153	acetyltransferase
S101392_RS05115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101392_RS05120	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
S101392_RS05125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
S101392_RS05130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
S101392_RS05135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
S101392_RS05140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
S101392_RS05145	COG2203	Gaf domain
S101392_RS05145	COG4585	Histidine kinase
S101392_RS05150	COG2197	response regulator
S101392_RS05155	COG0431	NADPH-dependent FMN reductase
S101392_RS05170	COG0791	NLP P60 protein
S101392_RS05170	COG1388	LysM domain
S101392_RS05175	COG1959	2 iron, 2 sulfur cluster binding
S101392_RS05180	COG0668	transmembrane transport
S101392_RS05185	COG2719	SpoVR family
S101392_RS05190	COG1785	Belongs to the alkaline phosphatase family
S101392_RS05195	COG1388	LysM domain
S101392_RS05195	COG0791	NLP P60 protein
S101392_RS05200	COG0583	DNA-binding transcription factor activity
S101392_RS05205	COG0372	Belongs to the citrate synthase family
S101392_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS05215	COG0531	amino acid
S101392_RS05220	COG0733	neurotransmitter:sodium symporter activity
S101392_RS05225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS05230	COG0456	acetyltransferase
S101392_RS05245	COG1595	DNA-templated transcription, initiation
S101392_RS05250	COG0667	Aldo Keto reductase
S101392_RS05255	COG0204	Acyl-transferase
S101392_RS05260	COG1253	flavin adenine dinucleotide binding
S101392_RS05265	COG0789	Transcriptional regulator
S101392_RS05270	COG0436	Aminotransferase
S101392_RS05275	COG1253	flavin adenine dinucleotide binding
S101392_RS05280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101392_RS05285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
S101392_RS05290	COG0584	glycerophosphoryl diester phosphodiesterase
S101392_RS05300	COG0668	transmembrane transport
S101392_RS05305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
S101392_RS05310	COG0726	polysaccharide deacetylase
S101392_RS05315	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101392_RS05320	COG1757	Na H antiporter
S101392_RS05325	COG0589	response to stress
S101392_RS05335	COG1132	(ABC) transporter
S101392_RS05340	COG1132	(ABC) transporter
S101392_RS05345	COG0702	epimerase
S101392_RS05365	COG0189	ligase activity
S101392_RS05370	COG0189	ligase activity
S101392_RS05375	COG4399	Belongs to the UPF0754 family
S101392_RS05380	COG3679	Belongs to the UPF0342 family
S101392_RS05385	COG4335	DNA alkylation repair
S101392_RS05390	COG0561	phosphatase activity
S101392_RS05395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101392_RS05400	COG0475	glutathione-regulated potassium exporter activity
S101392_RS05405	COG0490	domain, Protein
S101392_RS05415	COG1024	Enoyl-CoA hydratase
S101392_RS05425	COG4152	abc transporter atp-binding protein
S101392_RS05430	COG1668	transmembrane transport
S101392_RS05435	COG0420	3'-5' exonuclease activity
S101392_RS05440	COG4717	serine-type aminopeptidase activity
S101392_RS05445	COG3481	metal-dependent phosphohydrolase, HD sub domain
S101392_RS05455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
S101392_RS05485	COG1846	Transcriptional regulator
S101392_RS05490	COG4980	gas vesicle protein
S101392_RS05505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
S101392_RS05510	COG0537	adenosine 5'-monophosphoramidase activity
S101392_RS05515	COG1131	(ABC) transporter
S101392_RS05520	COG4473	ABC transporter
S101392_RS05530	COG1473	amidohydrolase
S101392_RS05535	COG3069	C4-dicarboxylate transmembrane transporter activity
S101392_RS05545	COG2329	Antibiotic biosynthesis monooxygenase
S101392_RS05550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101392_RS05555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
S101392_RS05560	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
S101392_RS05565	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
S101392_RS05570	COG1309	transcriptional regulator
S101392_RS05575	COG1511	domain protein
S101392_RS05580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101392_RS05585	COG4377	Putative membrane peptidase family (DUF2324)
S101392_RS05595	COG1363	Peptidase, m42
S101392_RS05600	COG4405	Protein conserved in bacteria
S101392_RS05605	COG1301	dicarboxylic acid transport
S101392_RS05615	COG1234	tRNA 3'-trailer cleavage
S101392_RS05620	COG0095	Lipoate-protein ligase
S101392_RS05625	COG0702	epimerase
S101392_RS05630	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS05640	COG0501	Belongs to the peptidase M48B family
S101392_RS05650	COG0456	acetyltransferase
S101392_RS05655	COG0604	alcohol dehydrogenase
S101392_RS05660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
S101392_RS05665	COG0406	alpha-ribazole phosphatase activity
S101392_RS05670	COG0183	Belongs to the thiolase family
S101392_RS05675	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS05680	COG1268	BioY protein
S101392_RS05685	COG0840	transmembrane signaling receptor activity
S101392_RS05690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101392_RS05690	COG0723	plastoquinol--plastocyanin reductase activity
S101392_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS05705	COG4903	ComK protein
S101392_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS05720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101392_RS05735	COG0398	Pfam SNARE associated Golgi protein
S101392_RS05740	COG0681	Belongs to the peptidase S26 family
S101392_RS05745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
S101392_RS05750	COG1846	Transcriptional regulator
S101392_RS05755	COG0738	Major facilitator superfamily
S101392_RS05760	COG0673	inositol 2-dehydrogenase activity
S101392_RS05765	COG0561	phosphatase activity
S101392_RS05770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101392_RS05775	COG1609	Transcriptional regulator
S101392_RS05780	COG3180	Ammonia monooxygenase
S101392_RS05785	COG0477	Major facilitator Superfamily
S101392_RS05785	COG2814	Major facilitator Superfamily
S101392_RS05790	COG4533	DNA binding
S101392_RS05800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
S101392_RS05805	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
S101392_RS05810	COG1074	ATP-dependent DNA helicase activity
S101392_RS05815	COG0420	3'-5' exonuclease activity
S101392_RS05820	COG0419	ATPase involved in DNA repair
S101392_RS05825	COG1403	HNH endonuclease
S101392_RS05865	COG5337	Spore coat protein CotH
S101392_RS05870	COG0179	Fumarylacetoacetate (FAA) hydrolase
S101392_RS05880	COG1404	Belongs to the peptidase S8 family
S101392_RS05890	COG0367	asparagine synthase
S101392_RS05895	COG2318	DinB family
S101392_RS05900	COG1562	ergosterol biosynthetic process
S101392_RS05905	COG0534	Mate efflux family protein
S101392_RS05910	COG2207	Transcriptional regulator
S101392_RS05910	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS05915	COG1609	Transcriptional regulator
S101392_RS05920	COG0673	inositol 2-dehydrogenase activity
S101392_RS05925	COG2318	DinB family
S101392_RS05930	COG1279	arginine transmembrane transporter activity
S101392_RS05935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
S101392_RS05940	COG1357	PFAM Pentapeptide repeats (8 copies)
S101392_RS05945	COG2267	carboxylic ester hydrolase activity
S101392_RS05950	COG0529	Catalyzes the synthesis of activated sulfate
S101392_RS05955	COG2046	Belongs to the sulfate adenylyltransferase family
S101392_RS05960	COG0175	sulfate reduction
S101392_RS05965	COG2045	Belongs to the ComB family
S101392_RS05970	COG1809	phosphosulfolactate synthase activity
S101392_RS05975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS05980	COG4948	Mandelate Racemase Muconate Lactonizing
S101392_RS05985	COG2814	Major facilitator Superfamily
S101392_RS05990	COG0454	-acetyltransferase
S101392_RS05995	COG2153	protein acetylation
S101392_RS06000	COG0646	methionine synthase
S101392_RS06000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
S101392_RS06005	COG1666	GTP binding
S101392_RS06010	COG2996	Protein conserved in bacteria
S101392_RS06030	COG1695	Transcriptional regulator
S101392_RS06045	COG3227	Zinc metalloprotease (Elastase)
S101392_RS06050	COG1307	EDD domain protein, DegV family
S101392_RS06055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS06070	COG0561	phosphatase activity
S101392_RS06075	COG1073	alpha beta
S101392_RS06080	COG2151	metal-sulfur cluster biosynthetic enzyme
S101392_RS06090	COG0277	FAD linked oxidase domain protein
S101392_RS06095	COG2271	Major facilitator Superfamily
S101392_RS06100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
S101392_RS06105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
S101392_RS06115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101392_RS06120	COG0505	Belongs to the CarA family
S101392_RS06125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101392_RS06130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
S101392_RS06145	COG2267	carboxylic ester hydrolase activity
S101392_RS06155	COG1744	ABC transporter substrate-binding protein PnrA-like
S101392_RS06170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101392_RS06175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101392_RS06180	COG5504	Zn-dependent protease
S101392_RS06185	COG0444	Belongs to the ABC transporter superfamily
S101392_RS06190	COG4608	Belongs to the ABC transporter superfamily
S101392_RS06200	COG0601	transmembrane transport
S101392_RS06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101392_RS06215	COG0180	Tryptophanyl-tRNA synthetase
S101392_RS06220	COG4166	transmembrane transport
S101392_RS06225	COG0601	transmembrane transport
S101392_RS06230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101392_RS06235	COG0444	Belongs to the ABC transporter superfamily
S101392_RS06240	COG4608	Belongs to the ABC transporter superfamily
S101392_RS06245	COG2814	Major facilitator Superfamily
S101392_RS06250	COG0456	acetyltransferase
S101392_RS06255	COG1393	Belongs to the ArsC family
S101392_RS06260	COG0861	Integral membrane protein TerC family
S101392_RS06265	COG4862	establishment of competence for transformation
S101392_RS06270	COG4469	Competence protein
S101392_RS06275	COG1164	Oligoendopeptidase f
S101392_RS06290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101392_RS06295	COG2346	COG2346, Truncated hemoglobins
S101392_RS06300	COG0741	lytic transglycosylase activity
S101392_RS06305	COG4116	CYTH
S101392_RS06315	COG2357	RelA SpoT domain protein
S101392_RS06320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101392_RS06325	COG0564	pseudouridine synthase activity
S101392_RS06330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
S101392_RS06335	COG0475	glutathione-regulated potassium exporter activity
S101392_RS06335	COG0569	domain protein
S101392_RS06340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
S101392_RS06345	COG0352	thiamine-phosphate diphosphorylase activity
S101392_RS06350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101392_RS06355	COG2104	thiamine diphosphate biosynthetic process
S101392_RS06360	COG2022	thiamine diphosphate biosynthetic process
S101392_RS06365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101392_RS06370	COG0351	phosphomethylpyrimidine kinase
S101392_RS06375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
S101392_RS06430	COG0210	DNA helicase
S101392_RS06440	COG2153	protein acetylation
S101392_RS06445	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101392_RS06450	COG2382	esterase
S101392_RS06455	COG0626	cystathionine gamma-synthase activity
S101392_RS06460	COG0626	cystathionine gamma-synthase activity
S101392_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS06470	COG5505	Protein of unknown function (DUF819)
S101392_RS06490	COG5444	nuclease activity
S101392_RS06515	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
S101392_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS06530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS06530	COG3711	transcriptional antiterminator
S101392_RS06535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101392_RS06535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101392_RS06535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS06540	COG1482	cell wall glycoprotein biosynthetic process
S101392_RS06550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS06555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
S101392_RS06575	COG0109	protoheme IX farnesyltransferase activity
S101392_RS06585	COG0726	polysaccharide deacetylase
S101392_RS06600	COG5504	Zn-dependent protease
S101392_RS06605	COG2205	protein histidine kinase activity
S101392_RS06615	COG3383	formate dehydrogenase (NAD+) activity
S101392_RS06620	COG2427	Protein of unknown function (DUF1641)
S101392_RS06630	COG1051	belongs to the nudix hydrolase family
S101392_RS06640	COG2124	cytochrome p450
S101392_RS06645	COG1819	glycosyl
S101392_RS06655	COG1587	Uroporphyrinogen-III synthase
S101392_RS06660	COG0390	transport system, permease component
S101392_RS06665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101392_RS06670	COG0697	spore germination
S101392_RS06675	COG4297	protein containing double-stranded beta helix domain
S101392_RS06685	COG1252	NADH dehydrogenase
S101392_RS06690	COG1904	glucuronate isomerase
S101392_RS06695	COG2211	Major facilitator Superfamily
S101392_RS06700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
S101392_RS06705	COG1063	alcohol dehydrogenase
S101392_RS06710	COG1312	Catalyzes the dehydration of D-mannonate
S101392_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS06720	COG2271	Major facilitator Superfamily
S101392_RS06725	COG1609	Transcriptional regulator
S101392_RS06730	COG0246	Mannitol dehydrogenase
S101392_RS06735	COG2721	sulfolactate sulfo-lyase activity
S101392_RS06740	COG0730	response to heat
S101392_RS06745	COG2318	DinB family
S101392_RS06750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
S101392_RS06755	COG0457	Tetratricopeptide repeat
S101392_RS06765	COG2350	Protein conserved in bacteria
S101392_RS06770	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS06770	COG1388	LysM domain
S101392_RS06770	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS06780	COG4195	phage-related replication protein
S101392_RS06785	COG3546	catalase activity
S101392_RS06790	COG2856	Zn peptidase
S101392_RS06795	COG1396	sequence-specific DNA binding
S101392_RS06805	COG1522	sequence-specific DNA binding
S101392_RS06810	COG1484	DNA-dependent DNA replication
S101392_RS06830	COG1595	DNA-templated transcription, initiation
S101392_RS06835	COG5484	DNA packaging
S101392_RS06835	COG3728	DNA packaging
S101392_RS06840	COG1783	phage Terminase large subunit
S101392_RS06845	COG5518	Phage portal protein
S101392_RS06850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
S101392_RS06855	COG4653	Phage capsid family
S101392_RS06905	COG5412	phage tail tape measure protein
S101392_RS06905	COG3953	SLT domain
S101392_RS06910	COG1652	LysM domain
S101392_RS06915	COG4193	domain, Protein
S101392_RS06925	COG3628	GPW Gp25 family protein
S101392_RS06930	COG3299	homolog of phage Mu protein gp47
S101392_RS06935	COG3778	Protein conserved in bacteria
S101392_RS06975	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS06975	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS06990	COG0306	phosphate transporter
S101392_RS06995	COG1392	Phosphate transport regulator
S101392_RS07000	COG0531	amino acid
S101392_RS07005	COG0346	lactoylglutathione lyase activity
S101392_RS07010	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101392_RS07015	COG0463	Glycosyl transferase, family 2
S101392_RS07020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101392_RS07025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101392_RS07030	COG2362	D-Aminopeptidase
S101392_RS07035	COG0601	transmembrane transport
S101392_RS07040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
S101392_RS07045	COG0444	Belongs to the ABC transporter superfamily
S101392_RS07050	COG4166	transmembrane transport
S101392_RS07055	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101392_RS07060	COG4948	Mandelate Racemase Muconate Lactonizing
S101392_RS07065	COG0791	NLP P60 protein
S101392_RS07070	COG4608	Belongs to the ABC transporter superfamily
S101392_RS07075	COG2706	6-phosphogluconolactonase activity
S101392_RS07080	COG1834	amidinotransferase
S101392_RS07085	COG1607	acyl-coa hydrolase
S101392_RS07090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
S101392_RS07090	COG1017	nitric oxide dioxygenase activity
S101392_RS07100	COG2323	membrane
S101392_RS07105	COG2318	DinB family
S101392_RS07110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS07115	COG2076	Multidrug Resistance protein
S101392_RS07120	COG2076	Multidrug Resistance protein
S101392_RS07125	COG0788	formyltetrahydrofolate deformylase activity
S101392_RS07130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101392_RS07135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
S101392_RS07140	COG1764	response to oxidative stress
S101392_RS07145	COG1846	Transcriptional regulator
S101392_RS07150	COG1764	response to oxidative stress
S101392_RS07160	COG0590	tRNA wobble adenosine to inosine editing
S101392_RS07165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101392_RS07170	COG1404	Belongs to the peptidase S8 family
S101392_RS07175	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS07180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
S101392_RS07185	COG1122	ATPase activity
S101392_RS07190	COG4721	ABC-type cobalt transport system, permease component
S101392_RS07200	COG0745	RESPONSE REGULATOR receiver
S101392_RS07205	COG5002	protein histidine kinase activity
S101392_RS07205	COG3850	Histidine kinase
S101392_RS07210	COG3212	peptidase
S101392_RS07215	COG3212	peptidase
S101392_RS07230	COG2239	Acts as a magnesium transporter
S101392_RS07235	COG0789	Transcriptional regulator
S101392_RS07250	COG1846	Transcriptional regulator
S101392_RS07255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101392_RS07260	COG0726	polysaccharide deacetylase
S101392_RS07265	COG1408	metallophosphoesterase
S101392_RS07275	COG0463	Glycosyl transferase, family 2
S101392_RS07280	COG3285	dna ligase
S101392_RS07280	COG1793	dna ligase
S101392_RS07285	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
S101392_RS07290	COG3300	MHYT domain
S101392_RS07290	COG5001	Diguanylate cyclase
S101392_RS07295	COG0586	Pfam SNARE associated Golgi protein
S101392_RS07300	COG0861	Integral membrane protein TerC family
S101392_RS07305	COG1191	sigma factor activity
S101392_RS07325	COG0501	Belongs to the peptidase M48B family
S101392_RS07330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101392_RS07345	COG3594	Acyltransferase
S101392_RS07350	COG5002	protein histidine kinase activity
S101392_RS07355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
S101392_RS07360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
S101392_RS07365	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
S101392_RS07370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
S101392_RS07375	COG0436	Aminotransferase
S101392_RS07380	COG1850	ribulose-bisphosphate carboxylase activity
S101392_RS07385	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
S101392_RS07390	COG0235	Class ii aldolase
S101392_RS07395	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
S101392_RS07400	COG3339	Conserved Protein
S101392_RS07415	COG3852	Histidine kinase
S101392_RS07425	COG1846	Transcriptional regulator
S101392_RS07430	COG1360	Flagellar Motor Protein
S101392_RS07435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101392_RS07445	COG0542	response to heat
S101392_RS07450	COG3949	Membrane
S101392_RS07455	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
S101392_RS07460	COG0720	synthase
S101392_RS07465	COG0602	queuosine metabolic process
S101392_RS07470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
S101392_RS07475	COG1733	regulation of RNA biosynthetic process
S101392_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS07485	COG1388	LysM domain
S101392_RS07485	COG4641	Protein conserved in bacteria
S101392_RS07490	COG1388	LysM domain
S101392_RS07495	COG3858	chitin binding
S101392_RS07505	COG4873	Protein conserved in bacteria
S101392_RS07515	COG3773	Cell wall hydrolase
S101392_RS07520	COG2244	polysaccharide biosynthetic process
S101392_RS07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS07530	COG2217	Heavy metal translocating P-type atpase
S101392_RS07540	COG0006	proline dipeptidase activity
S101392_RS07545	COG1609	Transcriptional regulator
S101392_RS07550	COG3711	transcriptional antiterminator
S101392_RS07555	COG1263	PTS System
S101392_RS07555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS07555	COG2190	(PTS) system
S101392_RS07560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS07565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
S101392_RS07575	COG1533	DNA photolyase activity
S101392_RS07580	COG0456	acetyltransferase
S101392_RS07585	COG0840	transmembrane signaling receptor activity
S101392_RS07590	COG2084	Dehydrogenase
S101392_RS07595	COG2340	Cysteine-rich secretory protein family
S101392_RS07600	COG0768	penicillin binding
S101392_RS07605	COG4191	Histidine kinase
S101392_RS07610	COG0436	Aminotransferase
S101392_RS07620	COG0835	chemotaxis
S101392_RS07620	COG0784	Response regulator, receiver
S101392_RS07630	COG2814	Major facilitator Superfamily
S101392_RS07635	COG1376	ErfK ybiS ycfS ynhG family protein
S101392_RS07640	COG1408	metallophosphoesterase
S101392_RS07645	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS07650	COG2200	EAL domain
S101392_RS07655	COG4703	Protein of unknown function (DUF1797)
S101392_RS07660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
S101392_RS07670	COG0517	IMP dehydrogenase activity
S101392_RS07675	COG0583	DNA-binding transcription factor activity
S101392_RS07680	COG0716	FMN binding
S101392_RS07690	COG0716	FMN binding
S101392_RS07695	COG2171	N-acyltransferase activity
S101392_RS07700	COG1473	amidohydrolase
S101392_RS07710	COG0668	transmembrane transport
S101392_RS07715	COG0450	alkyl hydroperoxide reductase
S101392_RS07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS07735	COG0746	molybdenum cofactor guanylyltransferase activity
S101392_RS07740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
S101392_RS07745	COG0303	'Molybdopterin
S101392_RS07750	COG1763	Mo-molybdopterin cofactor biosynthetic process
S101392_RS07755	COG0314	molybdopterin synthase activity
S101392_RS07760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
S101392_RS07765	COG1132	(ABC) transporter
S101392_RS07770	COG1132	(ABC) transporter
S101392_RS07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101392_RS07785	COG1136	(ABC) transporter
S101392_RS07790	COG0577	efflux transmembrane transporter activity
S101392_RS07795	COG1349	DNA-binding transcription factor activity
S101392_RS07800	COG1105	Belongs to the carbohydrate kinase PfkB family
S101392_RS07805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS07805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101392_RS07805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
S101392_RS07810	COG0681	Belongs to the peptidase S26 family
S101392_RS07820	COG0488	(ABC) transporter
S101392_RS07825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101392_RS07830	COG2309	aminopeptidase activity
S101392_RS07840	COG1077	Cell shape determining protein MreB Mrl
S101392_RS07845	COG2002	toxin-antitoxin pair type II binding
S101392_RS07850	COG3852	Histidine kinase
S101392_RS07855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
S101392_RS07855	COG2105	PFAM AIG2 family protein
S101392_RS07860	COG0569	domain protein
S101392_RS07865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
S101392_RS07870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101392_RS07875	COG5503	Protein of unknown function (DUF1447)
S101392_RS07880	COG0561	phosphatase activity
S101392_RS07885	COG0242	peptide deformylase activity
S101392_RS07895	COG0497	DNA recombination
S101392_RS07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101392_RS07905	COG0022	dehydrogenase e1 component
S101392_RS07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101392_RS07915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101392_RS07920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS07930	COG1982	Orn Lys Arg decarboxylase major
S101392_RS07935	COG4476	Belongs to the UPF0223 family
S101392_RS07940	COG4493	Belongs to the UPF0637 family
S101392_RS07950	COG0483	inositol monophosphate 1-phosphatase activity
S101392_RS07960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
S101392_RS07980	COG1595	DNA-templated transcription, initiation
S101392_RS08000	COG1217	gtp-binding protein TYPA
S101392_RS08010	COG4896	Protein conserved in bacteria
S101392_RS08020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
S101392_RS08025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101392_RS08030	COG2066	Belongs to the glutaminase family
S101392_RS08035	COG4838	Belongs to the UPF0358 family
S101392_RS08040	COG0772	Belongs to the SEDS family
S101392_RS08045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
S101392_RS08050	COG1612	heme a metabolic process
S101392_RS08055	COG0109	protoheme IX farnesyltransferase activity
S101392_RS08060	COG2010	Cytochrome c
S101392_RS08060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101392_RS08065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101392_RS08070	COG1845	cytochrome c oxidase, subunit III
S101392_RS08075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101392_RS08080	COG3336	cytochrome c oxidase
S101392_RS08090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
S101392_RS08095	COG2340	Cysteine-rich secretory protein family
S101392_RS08110	COG3679	Belongs to the UPF0342 family
S101392_RS08115	COG4471	UPF0298 protein
S101392_RS08120	COG0742	ribosomal rna small subunit methyltransferase
S101392_RS08125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
S101392_RS08130	COG3314	Sporulation integral membrane protein YlbJ
S101392_RS08135	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101392_RS08140	COG3480	Lon protease (S16) C-terminal proteolytic domain
S101392_RS08145	COG1323	Belongs to the UPF0348 family
S101392_RS08155	COG1399	metal-binding, possibly nucleic acid-binding protein
S101392_RS08170	COG0454	-acetyltransferase
S101392_RS08175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
S101392_RS08180	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
S101392_RS08185	COG2001	Belongs to the MraZ family
S101392_RS08190	COG0275	rRNA processing
S101392_RS08195	COG4839	cell division protein FtsL
S101392_RS08200	COG0768	penicillin binding
S101392_RS08205	COG0768	penicillin binding
S101392_RS08210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
S101392_RS08215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101392_RS08220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101392_RS08225	COG0772	Belongs to the SEDS family
S101392_RS08230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101392_RS08235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
S101392_RS08240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
S101392_RS08245	COG3879	Bacterial protein of unknown function (DUF881)
S101392_RS08250	COG3879	Bacterial protein of unknown function (DUF881)
S101392_RS08255	COG3856	small basic protein
S101392_RS08260	COG0849	cell division
S101392_RS08265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
S101392_RS08270	COG1404	Belongs to the peptidase S8 family
S101392_RS08270	COG4412	M6 family metalloprotease domain protein
S101392_RS08280	COG1191	sigma factor activity
S101392_RS08285	COG1191	sigma factor activity
S101392_RS08290	COG1119	ATPase activity
S101392_RS08295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101392_RS08300	COG1873	PFAM PRC-barrel domain
S101392_RS08305	COG1496	oxidoreductase activity
S101392_RS08310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
S101392_RS08315	COG1799	cell septum assembly
S101392_RS08320	COG0762	integral membrane protein
S101392_RS08325	COG2302	S4 RNA-binding domain
S101392_RS08330	COG3599	regulation of cell shape
S101392_RS08335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
S101392_RS08340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101392_RS08345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
S101392_RS08350	COG0564	pseudouridine synthase activity
S101392_RS08355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
S101392_RS08360	COG2233	PERMEase
S101392_RS08365	COG0540	Belongs to the ATCase OTCase family
S101392_RS08370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101392_RS08375	COG0505	Belongs to the CarA family
S101392_RS08380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
S101392_RS08385	COG0543	2 iron, 2 sulfur cluster binding
S101392_RS08390	COG0167	dihydroorotate dehydrogenase activity
S101392_RS08395	COG0284	orotidine-5'-phosphate decarboxylase activity
S101392_RS08400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
S101392_RS08405	COG0175	sulfate reduction
S101392_RS08410	COG0306	phosphate transporter
S101392_RS08415	COG2046	Belongs to the sulfate adenylyltransferase family
S101392_RS08420	COG0529	Catalyzes the synthesis of activated sulfate
S101392_RS08425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
S101392_RS08430	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
S101392_RS08435	COG1648	precorrin-2 dehydrogenase activity
S101392_RS08440	COG1293	RNA-binding protein homologous to eukaryotic snRNP
S101392_RS08445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101392_RS08450	COG1561	YicC-like family, N-terminal region
S101392_RS08460	COG0194	GDP metabolic process
S101392_RS08465	COG1758	RNA polymerase activity
S101392_RS08470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101392_RS08475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
S101392_RS08480	COG0242	peptide deformylase activity
S101392_RS08485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
S101392_RS08490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
S101392_RS08490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101392_RS08495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
S101392_RS08500	COG0631	protein serine/threonine phosphatase activity
S101392_RS08505	COG2815	serine threonine protein kinase
S101392_RS08505	COG0515	serine threonine protein kinase
S101392_RS08510	COG1162	GTPase activity
S101392_RS08515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
S101392_RS08520	COG1564	THIamine pyrophosphokinase
S101392_RS08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
S101392_RS08535	COG1302	Protein conserved in bacteria
S101392_RS08540	COG1461	Dihydroxyacetone kinase
S101392_RS08545	COG1760	l-serine dehydratase
S101392_RS08550	COG1760	l-serine dehydratase
S101392_RS08555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
S101392_RS08560	COG2050	protein possibly involved in aromatic compounds catabolism
S101392_RS08560	COG1349	DNA-binding transcription factor activity
S101392_RS08565	COG0416	fatty acid biosynthetic process
S101392_RS08570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101392_RS08575	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS08585	COG0571	ribonuclease III activity
S101392_RS08590	COG1196	nuclear chromosome segregation
S101392_RS08595	COG0552	protein localization to endoplasmic reticulum
S101392_RS08605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
S101392_RS08610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
S101392_RS08615	COG0228	four-way junction DNA binding
S101392_RS08620	COG1837	Belongs to the UPF0109 family
S101392_RS08630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
S101392_RS08635	COG0336	Belongs to the RNA methyltransferase TrmD family
S101392_RS08640	COG0335	large ribosomal subunit rRNA binding
S101392_RS08645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
S101392_RS08650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101392_RS08660	COG2257	FlhB HrpN YscU SpaS Family
S101392_RS08665	COG0045	succinate-CoA ligase (ADP-forming) activity
S101392_RS08670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
S101392_RS08675	COG0758	DNA mediated transformation
S101392_RS08680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
S101392_RS08685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
S101392_RS08690	COG4974	Belongs to the 'phage' integrase family
S101392_RS08695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
S101392_RS08700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
S101392_RS08705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101392_RS08710	COG1815	bacterial-type flagellum-dependent cell motility
S101392_RS08715	COG1558	bacterial-type flagellum-dependent cell motility
S101392_RS08720	COG1677	Flagellar hook-basal body complex protein FliE
S101392_RS08725	COG1766	The M ring may be actively involved in energy transduction
S101392_RS08730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101392_RS08735	COG1317	bacterial-type flagellum organization
S101392_RS08740	COG1157	protein secretion by the type III secretion system
S101392_RS08745	COG2882	bacterial-type flagellum organization
S101392_RS08750	COG3334	PFAM MgtE intracellular
S101392_RS08755	COG3144	bacterial-type flagellum assembly
S101392_RS08760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
S101392_RS08765	COG4786	Flagellar basal body rod
S101392_RS08770	COG1582	Flagellar protein (FlbD)
S101392_RS08775	COG1580	Controls the rotational direction of flagella during chemotaxis
S101392_RS08780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101392_RS08785	COG1776	CheC inhibitor of MCP methylation
S101392_RS08785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
S101392_RS08790	COG2201	protein-glutamate methylesterase activity
S101392_RS08795	COG3190	flagellar
S101392_RS08800	COG1338	Plays a role in the flagellum-specific transport system
S101392_RS08805	COG1987	bacterial-type flagellum assembly
S101392_RS08810	COG1684	flagellar biosynthetic protein fliR
S101392_RS08815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101392_RS08820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
S101392_RS08825	COG1419	protein localization to endoplasmic reticulum
S101392_RS08830	COG0455	bacterial-type flagellum organization
S101392_RS08835	COG2201	protein-glutamate methylesterase activity
S101392_RS08840	COG2198	Histidine kinase
S101392_RS08840	COG0643	Histidine kinase
S101392_RS08845	COG0835	chemotaxis
S101392_RS08850	COG1776	CheC inhibitor of MCP methylation
S101392_RS08855	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
S101392_RS08860	COG1191	sigma factor activity
S101392_RS08870	COG0052	Belongs to the universal ribosomal protein uS2 family
S101392_RS08875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
S101392_RS08880	COG0528	UMP kinase activity
S101392_RS08885	COG0233	cytoplasmic translational termination
S101392_RS08890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
S101392_RS08895	COG4589	Belongs to the CDS family
S101392_RS08900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
S101392_RS08905	COG0750	zinc metalloprotease
S101392_RS08910	COG0442	prolyl-tRNA aminoacylation
S101392_RS08915	COG2176	DNA-directed DNA polymerase activity
S101392_RS08920	COG0779	Required for maturation of 30S ribosomal subunits
S101392_RS08925	COG0195	Participates in both transcription termination and antitermination
S101392_RS08930	COG2740	Nucleic-acid-binding protein implicated in transcription termination
S101392_RS08935	COG1358	cellular component organization or biogenesis
S101392_RS08945	COG1550	Protein conserved in bacteria
S101392_RS08950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
S101392_RS08955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
S101392_RS08960	COG0196	riboflavin kinase activity
S101392_RS08965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
S101392_RS08970	COG1185	polyribonucleotide nucleotidyltransferase activity
S101392_RS08975	COG0726	polysaccharide deacetylase
S101392_RS08980	COG0612	Peptidase, M16
S101392_RS08985	COG1873	PFAM PRC-barrel domain
S101392_RS08990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101392_RS08995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
S101392_RS09000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
S101392_RS09005	COG0527	aspartate kinase activity
S101392_RS09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
S101392_RS09015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
S101392_RS09020	COG0740	serine-type endopeptidase activity
S101392_RS09030	COG4980	gas vesicle protein
S101392_RS09030	COG1674	ftsk spoiiie
S101392_RS09035	COG2188	Transcriptional regulator
S101392_RS09040	COG2814	Major facilitator Superfamily
S101392_RS09045	COG0612	Peptidase, M16
S101392_RS09050	COG0612	Peptidase, M16
S101392_RS09055	COG0300	oxidoreductase activity
S101392_RS09070	COG1426	Protein conserved in bacteria
S101392_RS09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
S101392_RS09080	COG1058	Belongs to the CinA family
S101392_RS09080	COG1546	Belongs to the CinA family
S101392_RS09085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
S101392_RS09090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101392_RS09095	COG1418	mRNA catabolic process
S101392_RS09100	COG1692	metallophosphoesterase
S101392_RS09105	COG2359	stage V sporulation protein S
S101392_RS09110	COG1063	alcohol dehydrogenase
S101392_RS09115	COG0156	8-amino-7-oxononanoate synthase activity
S101392_RS09120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101392_RS09125	COG4550	Control of competence regulator ComK, YlbF/YmcA
S101392_RS09135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
S101392_RS09140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
S101392_RS09155	COG3226	Transcriptional regulator
S101392_RS09160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS09170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101392_RS09175	COG3321	synthase
S101392_RS09180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
S101392_RS09180	COG2070	2-Nitropropane dioxygenase
S101392_RS09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS09190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
S101392_RS09195	COG3425	synthase
S101392_RS09200	COG1024	Enoyl-CoA hydratase
S101392_RS09205	COG1024	Enoyl-CoA hydratase
S101392_RS09210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS09210	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS09210	COG3321	synthase
S101392_RS09210	COG0300	oxidoreductase activity
S101392_RS09210	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS09215	COG4221	oxidoreductase activity
S101392_RS09215	COG0300	oxidoreductase activity
S101392_RS09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS09215	COG3321	synthase
S101392_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101392_RS09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS09220	COG3321	synthase
S101392_RS09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS09225	COG4221	oxidoreductase activity
S101392_RS09225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS09225	COG3321	synthase
S101392_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS09230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S101392_RS09230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
S101392_RS09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS09230	COG3321	synthase
S101392_RS09235	COG2124	cytochrome p450
S101392_RS09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS09250	COG1404	Belongs to the peptidase S8 family
S101392_RS09260	COG4195	phage-related replication protein
S101392_RS09265	COG1764	response to oxidative stress
S101392_RS09270	COG2076	Multidrug Resistance protein
S101392_RS09275	COG2076	Multidrug Resistance protein
S101392_RS09290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
S101392_RS09295	COG1923	regulation of RNA biosynthetic process
S101392_RS09310	COG1780	Probably involved in ribonucleotide reductase function
S101392_RS09315	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101392_RS09320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
S101392_RS09325	COG4112	unkown
S101392_RS09330	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS09340	COG0464	growth
S101392_RS09345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
S101392_RS09350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
S101392_RS09355	COG0789	Transcriptional regulator
S101392_RS09360	COG0174	glutamine synthetase
S101392_RS09375	COG1396	sequence-specific DNA binding
S101392_RS09395	COG3646	Phage regulatory protein
S101392_RS09395	COG3645	SOS response
S101392_RS09420	COG0305	Participates in initiation and elongation during chromosome replication
S101392_RS09445	COG0582	viral genome integration into host DNA
S101392_RS09555	COG5280	Phage tail tape measure protein TP901
S101392_RS09555	COG3953	SLT domain
S101392_RS09565	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101392_RS09595	COG4824	toxin secretion phage lysis holin
S101392_RS09600	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS09600	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS09600	COG1388	LysM domain
S101392_RS09610	COG5444	nuclease activity
S101392_RS09615	COG0457	Tetratricopeptide repeat
S101392_RS09625	COG4974	Belongs to the 'phage' integrase family
S101392_RS09635	COG1396	sequence-specific DNA binding
S101392_RS09640	COG1396	sequence-specific DNA binding
S101392_RS09640	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS09700	COG0582	viral genome integration into host DNA
S101392_RS09800	COG5412	phage tail tape measure protein
S101392_RS09800	COG3953	SLT domain
S101392_RS09835	COG4824	toxin secretion phage lysis holin
S101392_RS09840	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS09840	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS09840	COG1388	LysM domain
S101392_RS09890	COG0463	Glycosyl transferase, family 2
S101392_RS09910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS09925	COG3655	Transcriptional regulator
S101392_RS09940	COG0135	phosphoribosylanthranilate isomerase activity
S101392_RS09945	COG2211	Major facilitator Superfamily
S101392_RS09950	COG3507	Belongs to the glycosyl hydrolase 43 family
S101392_RS09955	COG1940	carbohydrate kinase activity
S101392_RS09960	COG2115	Belongs to the xylose isomerase family
S101392_RS09965	COG1070	Carbohydrate kinase
S101392_RS09975	COG1525	nuclease
S101392_RS09980	COG2814	Major facilitator Superfamily
S101392_RS09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
S101392_RS09995	COG0756	dUTP diphosphatase activity
S101392_RS10030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
S101392_RS10045	COG3832	glyoxalase III activity
S101392_RS10060	COG0697	spore germination
S101392_RS10065	COG0531	amino acid
S101392_RS10095	COG4195	phage-related replication protein
S101392_RS10105	COG0346	lactoylglutathione lyase activity
S101392_RS10115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
S101392_RS10120	COG1388	LysM domain
S101392_RS10125	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101392_RS10130	COG4224	UPF0291 protein
S101392_RS10135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
S101392_RS10145	COG3763	UPF0154 protein
S101392_RS10155	COG0785	Cytochrome C biogenesis protein
S101392_RS10160	COG2201	protein-glutamate methylesterase activity
S101392_RS10165	COG4846	Membrane protein involved in cytochrome C biogenesis
S101392_RS10175	COG0071	Belongs to the small heat shock protein (HSP20) family
S101392_RS10190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
S101392_RS10195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS10215	COG0824	Thioesterase
S101392_RS10225	COG4841	protein insertion into membrane
S101392_RS10230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
S101392_RS10235	COG1832	CoA-binding protein
S101392_RS10240	COG0187	DNA topoisomerase II activity
S101392_RS10245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
S101392_RS10255	COG1115	amino acid carrier protein
S101392_RS10260	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
S101392_RS10270	COG5520	Belongs to the glycosyl hydrolase 30 family
S101392_RS10275	COG3507	Belongs to the glycosyl hydrolase 43 family
S101392_RS10280	COG2246	polysaccharide biosynthetic process
S101392_RS10285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101392_RS10290	COG0586	Pfam SNARE associated Golgi protein
S101392_RS10295	COG2404	hydrolase activity, acting on ester bonds
S101392_RS10300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101392_RS10305	COG1024	Enoyl-CoA hydratase
S101392_RS10310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101392_RS10315	COG0511	ligase activity, forming carbon-carbon bonds
S101392_RS10320	COG0439	Biotin carboxylase
S101392_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS10330	COG1960	acyl-CoA dehydrogenase activity
S101392_RS10340	COG1649	PFAM Uncharacterised BCR, COG1649
S101392_RS10350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS10350	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
S101392_RS10355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS10360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS10365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS10370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS10375	COG2027	D-alanyl-D-alanine carboxypeptidase
S101392_RS10380	COG2017	converts alpha-aldose to the beta-anomer
S101392_RS10385	COG0534	Mate efflux family protein
S101392_RS10400	COG0582	viral genome integration into host DNA
S101392_RS10405	COG0166	Belongs to the GPI family
S101392_RS10410	COG0405	Gamma-glutamyltransferase
S101392_RS10415	COG0583	DNA-binding transcription factor activity
S101392_RS10420	COG0604	alcohol dehydrogenase
S101392_RS10425	COG0493	'glutamate synthase
S101392_RS10430	COG0069	glutamate synthase activity
S101392_RS10430	COG0070	glutamate synthase
S101392_RS10430	COG0067	glutamate synthase
S101392_RS10435	COG0583	DNA-binding transcription factor activity
S101392_RS10440	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
S101392_RS10445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101392_RS10455	COG0300	oxidoreductase activity
S101392_RS10460	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101392_RS10470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
S101392_RS10475	COG2814	Major facilitator Superfamily
S101392_RS10480	COG1070	Carbohydrate kinase
S101392_RS10485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101392_RS10490	COG0243	molybdopterin cofactor binding
S101392_RS10515	COG5278	phosphoserine phosphatase activity
S101392_RS10515	COG0840	transmembrane signaling receptor activity
S101392_RS10520	COG2368	4-hydroxyphenylacetate
S101392_RS10525	COG4305	rare lipoprotein A
S101392_RS10530	COG3619	membrane
S101392_RS10535	COG3866	Pectate lyase
S101392_RS10540	COG2135	peptidase activity
S101392_RS10550	COG2140	Oxalate decarboxylase
S101392_RS10560	COG0456	acetyltransferase
S101392_RS10580	COG2720	vancomycin resistance protein
S101392_RS10590	COG3655	Transcriptional regulator
S101392_RS10595	COG3739	integral membrane protein
S101392_RS10600	COG0583	DNA-binding transcription factor activity
S101392_RS10605	COG0697	spore germination
S101392_RS10615	COG0693	protein deglycase activity
S101392_RS10620	COG2367	Beta-lactamase
S101392_RS10625	COG4282	regulation of fungal-type cell wall biogenesis
S101392_RS10645	COG0574	Belongs to the PEP-utilizing enzyme family
S101392_RS10645	COG3848	Pyruvate phosphate dikinase
S101392_RS10650	COG0726	polysaccharide deacetylase
S101392_RS10660	COG2314	TM2 domain
S101392_RS10665	COG1396	sequence-specific DNA binding
S101392_RS10700	COG1793	dna ligase
S101392_RS10740	COG1388	LysM domain
S101392_RS10770	COG0457	Tetratricopeptide repeat
S101392_RS10780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101392_RS10815	COG4282	regulation of fungal-type cell wall biogenesis
S101392_RS10820	COG1231	oxidoreductase activity
S101392_RS10825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101392_RS10830	COG2207	Transcriptional regulator
S101392_RS10830	COG0662	Cupin 2, conserved barrel domain protein
S101392_RS10835	COG0456	acetyltransferase
S101392_RS10840	COG1309	transcriptional regulator
S101392_RS10845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS10850	COG3708	Transcriptional regulator
S101392_RS10855	COG2378	regulation of single-species biofilm formation
S101392_RS10865	COG0640	Transcriptional regulator
S101392_RS10870	COG0741	lytic transglycosylase activity
S101392_RS10875	COG2322	membrane
S101392_RS10890	COG1619	proteins homologs of microcin C7 resistance protein MccF
S101392_RS10895	COG3239	Fatty acid desaturase
S101392_RS10900	COG4585	Histidine kinase
S101392_RS10905	COG2197	response regulator
S101392_RS10910	COG1388	LysM domain
S101392_RS10910	COG3584	3D domain protein
S101392_RS10915	COG0514	ATP-dependent DNA helicase (RecQ)
S101392_RS10930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101392_RS10935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101392_RS10950	COG0071	Belongs to the small heat shock protein (HSP20) family
S101392_RS10975	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS10980	COG1657	PFAM Prenyltransferase squalene oxidase
S101392_RS10985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101392_RS10990	COG0733	neurotransmitter:sodium symporter activity
S101392_RS10995	COG0385	Bile acid
S101392_RS11000	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101392_RS11005	COG0567	Dehydrogenase, E1 component
S101392_RS11010	COG4548	von Willebrand factor, type A
S101392_RS11015	COG0714	Associated with various cellular activities
S101392_RS11020	COG2032	superoxide dismutase activity
S101392_RS11025	COG0791	NLP P60 protein
S101392_RS11025	COG1388	LysM domain
S101392_RS11030	COG1819	glycosyl
S101392_RS11035	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
S101392_RS11040	COG0534	Mate efflux family protein
S101392_RS11045	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS11050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101392_RS11055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101392_RS11065	COG2962	Rard protein
S101392_RS11080	COG2610	gluconate transmembrane transporter activity
S101392_RS11085	COG1942	4-Oxalocrotonate Tautomerase
S101392_RS11095	COG1733	regulation of RNA biosynthetic process
S101392_RS11100	COG0778	Nitroreductase
S101392_RS11105	COG0400	carboxylic ester hydrolase activity
S101392_RS11110	COG0346	lactoylglutathione lyase activity
S101392_RS11120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101392_RS11125	COG0793	Belongs to the peptidase S41A family
S101392_RS11125	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS11130	COG2226	methyltransferase
S101392_RS11140	COG1876	peptidase activity
S101392_RS11145	COG0813	purine-nucleoside phosphorylase activity
S101392_RS11160	COG0671	phosphoesterase, PA-phosphatase related
S101392_RS11185	COG4479	Belongs to the UPF0346 family
S101392_RS11195	COG1509	lysine 2,3-aminomutase activity
S101392_RS11200	COG0456	acetyltransferase
S101392_RS11205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101392_RS11210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101392_RS11215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101392_RS11220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101392_RS11230	COG0456	acetyltransferase
S101392_RS11235	COG0463	Glycosyl transferase, family 2
S101392_RS11250	COG4641	Protein conserved in bacteria
S101392_RS11255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
S101392_RS11260	COG1086	Polysaccharide biosynthesis protein
S101392_RS11265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101392_RS11270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
S101392_RS11275	COG1846	Transcriptional regulator
S101392_RS11280	COG0534	Mate efflux family protein
S101392_RS11290	COG4698	Protein conserved in bacteria
S101392_RS11295	COG2755	lipolytic protein G-D-S-L family
S101392_RS11300	COG1999	signal sequence binding
S101392_RS11310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
S101392_RS11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101392_RS11320	COG1272	protein, Hemolysin III
S101392_RS11325	COG0204	Acyl-transferase
S101392_RS11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101392_RS11335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
S101392_RS11340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101392_RS11350	COG2521	methyltransferase
S101392_RS11350	COG2136	Putative SAM-dependent methyltransferase
S101392_RS11360	COG0129	dihydroxy-acid dehydratase activity
S101392_RS11365	COG1413	lyase activity
S101392_RS11370	COG1418	mRNA catabolic process
S101392_RS11375	COG0386	Belongs to the glutathione peroxidase family
S101392_RS11380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
S101392_RS11385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
S101392_RS11390	COG1278	Cold shock
S101392_RS11410	COG0328	RNA-DNA hybrid ribonuclease activity
S101392_RS11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
S101392_RS11420	COG0328	RNA-DNA hybrid ribonuclease activity
S101392_RS11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101392_RS11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101392_RS11450	COG1755	Isoprenylcysteine carboxyl methyltransferase
S101392_RS11455	COG3424	synthase
S101392_RS11460	COG2233	PERMEase
S101392_RS11465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101392_RS11470	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
S101392_RS11480	COG0800	Aldolase
S101392_RS11485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101392_RS11490	COG1609	Transcriptional regulator
S101392_RS11495	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
S101392_RS11500	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS11505	COG1199	ATP-dependent helicase activity
S101392_RS11520	COG0116	Belongs to the methyltransferase superfamily
S101392_RS11535	COG4474	Belongs to the UPF0398 family
S101392_RS11545	COG3359	exonuclease
S101392_RS11550	COG1205	dead DEAH box helicase
S101392_RS11550	COG1111	helicase
S101392_RS11555	COG2190	(PTS) system
S101392_RS11560	COG0071	Belongs to the small heat shock protein (HSP20) family
S101392_RS11595	COG3331	DNA recombination
S101392_RS11600	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101392_RS11600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101392_RS11610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
S101392_RS11615	COG3935	DnaD domain protein
S101392_RS11620	COG0017	Asparaginyl-tRNA synthetase
S101392_RS11625	COG0436	Aminotransferase
S101392_RS11630	COG5353	protein conserved in bacteria
S101392_RS11640	COG1199	ATP-dependent helicase activity
S101392_RS11640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
S101392_RS11645	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
S101392_RS11650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
S101392_RS11655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
S101392_RS11660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
S101392_RS11660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
S101392_RS11665	COG0617	tRNA 3'-terminal CCA addition
S101392_RS11670	COG0438	transferase activity, transferring glycosyl groups
S101392_RS11675	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101392_RS11680	COG1803	Methylglyoxal synthase
S101392_RS11685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
S101392_RS11690	COG1694	Mazg nucleotide pyrophosphohydrolase
S101392_RS11695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS11705	COG4347	Protein of unknown function (DUF1405)
S101392_RS11710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101392_RS11710	COG2010	Cytochrome c
S101392_RS11715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
S101392_RS11720	COG0723	plastoquinol--plastocyanin reductase activity
S101392_RS11730	COG5582	Belongs to the UPF0302 family
S101392_RS11735	COG0457	Tetratricopeptide repeat
S101392_RS11740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
S101392_RS11745	COG0287	Prephenate dehydrogenase
S101392_RS11750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
S101392_RS11755	COG0159	tryptophan synthase activity
S101392_RS11760	COG0133	tryptophan synthase activity
S101392_RS11765	COG0135	phosphoribosylanthranilate isomerase activity
S101392_RS11775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
S101392_RS11780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
S101392_RS11785	COG4401	Chorismate mutase type I
S101392_RS11790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
S101392_RS11795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
S101392_RS11800	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
S101392_RS11805	COG0105	UTP biosynthetic process
S101392_RS11810	COG0142	geranyltranstransferase activity
S101392_RS11815	COG2226	methyltransferase
S101392_RS11820	COG0142	geranyltranstransferase activity
S101392_RS11830	COG0302	gtp cyclohydrolase
S101392_RS11835	COG0776	regulation of translation
S101392_RS11840	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
S101392_RS11855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
S101392_RS11860	COG1160	GTP binding
S101392_RS11885	COG1304	FMN binding
S101392_RS11890	COG0539	negative regulation of cytoplasmic translation
S101392_RS11895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
S101392_RS11905	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
S101392_RS11910	COG2959	enzyme of heme biosynthesis
S101392_RS11915	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS11915	COG3773	Cell wall hydrolase
S101392_RS11920	COG2339	peptidase activity
S101392_RS11925	COG0492	ferredoxin-NADP+ reductase activity
S101392_RS11930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101392_RS11935	COG4862	establishment of competence for transformation
S101392_RS11940	COG1408	metallophosphoesterase
S101392_RS11950	COG1388	LysM domain
S101392_RS11955	COG1266	CAAX protease self-immunity
S101392_RS11960	COG0514	ATP-dependent DNA helicase (RecQ)
S101392_RS11965	COG4955	Helix-turn-helix domain
S101392_RS11970	COG1141	Ferredoxin
S101392_RS11975	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
S101392_RS11980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
S101392_RS11985	COG0710	3-dehydroquinate dehydratase activity
S101392_RS11995	COG1595	DNA-templated transcription, initiation
S101392_RS12000	COG5002	protein histidine kinase activity
S101392_RS12005	COG0745	RESPONSE REGULATOR receiver
S101392_RS12010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101392_RS12015	COG1333	cytochrome c biogenesis protein
S101392_RS12020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS12025	COG1187	pseudouridine synthase activity
S101392_RS12030	COG0700	Nucleoside recognition
S101392_RS12035	COG2715	membrane protein required for spore maturation
S101392_RS12040	COG1686	Belongs to the peptidase S11 family
S101392_RS12050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
S101392_RS12055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
S101392_RS12060	COG1547	Domain of unknown function (DUF309)
S101392_RS12065	COG0456	acetyltransferase
S101392_RS12070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
S101392_RS12075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101392_RS12075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
S101392_RS12080	COG0307	riboflavin synthase, alpha
S101392_RS12085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101392_RS12085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
S101392_RS12095	COG0681	Belongs to the peptidase S26 family
S101392_RS12105	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
S101392_RS12135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
S101392_RS12145	COG4086	secreted protein
S101392_RS12150	COG0019	diaminopimelate decarboxylase activity
S101392_RS12155	COG0697	spore germination
S101392_RS12170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
S101392_RS12190	COG1191	sigma factor activity
S101392_RS12195	COG2172	sigma factor antagonist activity
S101392_RS12200	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS12205	COG1686	Belongs to the peptidase S11 family
S101392_RS12210	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
S101392_RS12215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
S101392_RS12220	COG4974	Belongs to the 'phage' integrase family
S101392_RS12230	COG0735	belongs to the Fur family
S101392_RS12235	COG1300	Membrane
S101392_RS12245	COG0281	malic enzyme
S101392_RS12250	COG1757	Na H antiporter
S101392_RS12255	COG1027	Aspartate ammonia-lyase
S101392_RS12260	COG0252	asparaginase activity
S101392_RS12265	COG1396	sequence-specific DNA binding
S101392_RS12270	COG1379	DNA repair
S101392_RS12275	COG0494	nUDIX hydrolase
S101392_RS12285	COG0667	Aldo Keto reductase
S101392_RS12295	COG1073	alpha beta
S101392_RS12305	COG4918	Iron-sulphur cluster biosynthesis
S101392_RS12310	COG0456	acetyltransferase
S101392_RS12310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
S101392_RS12315	COG2329	Antibiotic biosynthesis monooxygenase
S101392_RS12320	COG0456	acetyltransferase
S101392_RS12330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101392_RS12340	COG2211	Major facilitator Superfamily
S101392_RS12350	COG0346	lactoylglutathione lyase activity
S101392_RS12355	COG1072	(Pantothenic acid kinase))
S101392_RS12360	COG3048	D-serine ammonia-lyase activity
S101392_RS12365	COG0300	oxidoreductase activity
S101392_RS12370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS12375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101392_RS12380	COG4187	Peptidase family M20/M25/M40
S101392_RS12385	COG1902	pentaerythritol trinitrate reductase activity
S101392_RS12390	COG0596	Alpha beta hydrolase
S101392_RS12400	COG1234	tRNA 3'-trailer cleavage
S101392_RS12405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
S101392_RS12410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101392_RS12415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
S101392_RS12425	COG0706	membrane insertase activity
S101392_RS12450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS12455	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS12460	COG2986	histidine ammonia-lyase
S101392_RS12470	COG0109	protoheme IX farnesyltransferase activity
S101392_RS12475	COG3361	conserved protein (COG2071)
S101392_RS12480	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101392_RS12485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
S101392_RS12490	COG0346	lactoylglutathione lyase activity
S101392_RS12495	COG1376	ErfK ybiS ycfS ynhG family protein
S101392_RS12500	COG4129	membrane
S101392_RS12505	COG1126	abc transporter atp-binding protein
S101392_RS12510	COG0765	amino acid transport
S101392_RS12515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS12525	COG1597	lipid kinase activity
S101392_RS12530	COG2814	Major facilitator Superfamily
S101392_RS12535	COG4978	Transcriptional regulator
S101392_RS12535	COG0789	Transcriptional regulator
S101392_RS12540	COG0508	dehydrogenase complex catalyzes the overall conversion of
S101392_RS12545	COG0022	dehydrogenase e1 component
S101392_RS12550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
S101392_RS12555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
S101392_RS12560	COG3426	butyrate kinase activity
S101392_RS12565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101392_RS12570	COG0280	phosphate acetyltransferase
S101392_RS12575	COG3290	protein histidine kinase activity
S101392_RS12575	COG3829	transcription factor binding
S101392_RS12585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
S101392_RS12590	COG2079	MmgE PrpD family protein
S101392_RS12595	COG0372	Belongs to the citrate synthase family
S101392_RS12600	COG1960	acyl-CoA dehydrogenase activity
S101392_RS12605	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101392_RS12610	COG0183	Belongs to the thiolase family
S101392_RS12615	COG0584	glycerophosphoryl diester phosphodiesterase
S101392_RS12620	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS12630	COG1902	pentaerythritol trinitrate reductase activity
S101392_RS12635	COG0745	RESPONSE REGULATOR receiver
S101392_RS12640	COG0750	zinc metalloprotease
S101392_RS12645	COG0497	DNA recombination
S101392_RS12650	COG1438	arginine binding
S101392_RS12655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
S101392_RS12660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
S101392_RS12665	COG0142	geranyltranstransferase activity
S101392_RS12670	COG1722	exodeoxyribonuclease VII activity
S101392_RS12675	COG1570	exodeoxyribonuclease VII activity
S101392_RS12680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
S101392_RS12685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
S101392_RS12690	COG1302	Protein conserved in bacteria
S101392_RS12695	COG0439	Biotin carboxylase
S101392_RS12700	COG0511	ligase activity, forming carbon-carbon bonds
S101392_RS12740	COG3854	ATPases associated with a variety of cellular activities
S101392_RS12750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
S101392_RS12755	COG0006	proline dipeptidase activity
S101392_RS12760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
S101392_RS12770	COG3872	metal-dependent enzyme
S101392_RS12780	COG1752	Esterase of the alpha-beta hydrolase superfamily
S101392_RS12785	COG1321	iron dependent repressor
S101392_RS12790	COG0095	Lipoate-protein ligase
S101392_RS12795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101392_RS12800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101392_RS12805	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
S101392_RS12810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
S101392_RS12815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101392_RS12830	COG1396	sequence-specific DNA binding
S101392_RS12840	COG0681	Belongs to the peptidase S26 family
S101392_RS12865	COG4940	Competence protein ComGF
S101392_RS12875	COG4970	Tfp pilus assembly protein FimT
S101392_RS12880	COG4537	Required for transformation and DNA binding
S101392_RS12885	COG1459	type II secretion system
S101392_RS12890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
S101392_RS12900	COG0598	Magnesium transport protein CorA
S101392_RS12905	COG1253	flavin adenine dinucleotide binding
S101392_RS12910	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS12920	COG1393	Belongs to the ArsC family
S101392_RS12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS12940	COG0011	TIGRFAM Protein of
S101392_RS12950	COG2866	Carboxypeptidase
S101392_RS12955	COG1368	sulfuric ester hydrolase activity
S101392_RS12960	COG1940	carbohydrate kinase activity
S101392_RS12965	COG4483	Protein conserved in bacteria
S101392_RS12970	COG0705	Rhomboid family
S101392_RS12970	COG0457	Tetratricopeptide repeat
S101392_RS12980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
S101392_RS12990	COG0438	transferase activity, transferring glycosyl groups
S101392_RS13005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101392_RS13010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101392_RS13015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
S101392_RS13020	COG0581	inorganic phosphate transmembrane transporter activity
S101392_RS13025	COG0573	inorganic phosphate transmembrane transporter activity
S101392_RS13030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
S101392_RS13035	COG0768	penicillin binding
S101392_RS13040	COG0477	Major facilitator Superfamily
S101392_RS13045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
S101392_RS13050	COG2839	Protein conserved in bacteria
S101392_RS13055	COG5521	maltodextrose utilization protein MalA
S101392_RS13060	COG1388	LysM domain
S101392_RS13065	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
S101392_RS13070	COG4709	membrane
S101392_RS13075	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
S101392_RS13080	COG0735	belongs to the Fur family
S101392_RS13085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS13095	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
S101392_RS13100	COG0513	Belongs to the DEAD box helicase family
S101392_RS13110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
S101392_RS13115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
S101392_RS13120	COG2384	SAM-dependent methyltransferase
S101392_RS13125	COG2010	Cytochrome c
S101392_RS13135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
S101392_RS13140	COG0358	DNA primase activity
S101392_RS13145	COG1671	Belongs to the UPF0178 family
S101392_RS13150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
S101392_RS13155	COG0517	IMP dehydrogenase activity
S101392_RS13160	COG0751	glycine-tRNA ligase activity
S101392_RS13165	COG0752	glycyl-tRNA synthetase alpha subunit
S101392_RS13170	COG1381	Involved in DNA repair and RecF pathway recombination
S101392_RS13180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
S101392_RS13185	COG0295	cytidine deaminase activity
S101392_RS13190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
S101392_RS13195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
S101392_RS13200	COG1480	7TM receptor with intracellular HD hydrolase
S101392_RS13205	COG1702	phosphate starvation-inducible protein PhoH
S101392_RS13210	COG0561	phosphatase activity
S101392_RS13225	COG4864	UPF0365 protein
S101392_RS13230	COG1030	water channel activity
S101392_RS13235	COG1610	YqeY-like protein
S101392_RS13245	COG1283	sodium-dependent phosphate transmembrane transporter activity
S101392_RS13250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
S101392_RS13255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
S101392_RS13260	COG2264	protein methyltransferase activity
S101392_RS13265	COG0484	heat shock protein binding
S101392_RS13270	COG0443	Heat shock 70 kDa protein
S101392_RS13275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
S101392_RS13280	COG1420	regulation of RNA biosynthetic process
S101392_RS13285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
S101392_RS13290	COG0481	GTPase activity
S101392_RS13300	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS13305	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
S101392_RS13310	COG0268	Binds directly to 16S ribosomal RNA
S101392_RS13325	COG2333	competence protein COMEC
S101392_RS13325	COG0658	competence protein
S101392_RS13330	COG2131	deaminase
S101392_RS13335	COG1596	polysaccharide export
S101392_RS13335	COG1555	photosystem II stabilization
S101392_RS13340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
S101392_RS13350	COG0799	negative regulation of ribosome biogenesis
S101392_RS13355	COG1713	HD superfamily hydrolase involved in NAD metabolism
S101392_RS13360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
S101392_RS13365	COG1534	Rna-binding protein
S101392_RS13370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
S101392_RS13380	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
S101392_RS13390	COG2755	lipolytic protein G-D-S-L family
S101392_RS13395	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS13395	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS13405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
S101392_RS13415	COG3209	COG3209 Rhs family protein
S101392_RS13430	COG0477	Major facilitator Superfamily
S101392_RS13435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
S101392_RS13445	COG4124	Belongs to the glycosyl hydrolase 26 family
S101392_RS13460	COG0457	Tetratricopeptide repeat
S101392_RS13480	COG5444	nuclease activity
S101392_RS13495	COG1388	LysM domain
S101392_RS13495	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS13495	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS13500	COG5632	N-Acetylmuramoyl-L-alanine amidase
S101392_RS13500	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS13505	COG4824	toxin secretion phage lysis holin
S101392_RS13510	COG1783	phage Terminase large subunit
S101392_RS13555	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
S101392_RS13565	COG1484	DNA-dependent DNA replication
S101392_RS13585	COG0563	adenylate kinase activity
S101392_RS13610	COG4124	Belongs to the glycosyl hydrolase 26 family
S101392_RS13615	COG0730	response to heat
S101392_RS13620	COG0425	Belongs to the sulfur carrier protein TusA family
S101392_RS13635	COG0425	Belongs to the sulfur carrier protein TusA family
S101392_RS13635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101392_RS13650	COG1937	Protein conserved in bacteria
S101392_RS13665	COG0662	Cupin 2, conserved barrel domain protein
S101392_RS13680	COG0789	Transcriptional regulator
S101392_RS13680	COG4978	Transcriptional regulator
S101392_RS13685	COG2814	Major facilitator Superfamily
S101392_RS13690	COG0456	acetyltransferase
S101392_RS13695	COG1253	flavin adenine dinucleotide binding
S101392_RS13705	COG0697	spore germination
S101392_RS13710	COG0583	DNA-binding transcription factor activity
S101392_RS13715	COG2072	flavoprotein involved in K transport
S101392_RS13720	COG1230	cation diffusion facilitator family transporter
S101392_RS13725	COG1942	4-Oxalocrotonate Tautomerase
S101392_RS13730	COG0583	DNA-binding transcription factor activity
S101392_RS13750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
S101392_RS13755	COG1522	sequence-specific DNA binding
S101392_RS13765	COG2124	cytochrome p450
S101392_RS13775	COG1335	isochorismatase
S101392_RS13785	COG2318	DinB family
S101392_RS13795	COG2070	2-Nitropropane dioxygenase
S101392_RS13810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101392_RS13825	COG3443	Belongs to the bacterial solute-binding protein 9 family
S101392_RS13830	COG1595	DNA-templated transcription, initiation
S101392_RS13835	COG0667	Aldo Keto reductase
S101392_RS13840	COG2851	Citrate transporter
S101392_RS13845	COG0583	DNA-binding transcription factor activity
S101392_RS13850	COG2828	Protein conserved in bacteria
S101392_RS13855	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS13860	COG5566	PFAM Mor transcription activator
S101392_RS13865	COG0596	Alpha beta hydrolase
S101392_RS13870	COG4991	sh3 domain protein
S101392_RS13875	COG4991	sh3 domain protein
S101392_RS13880	COG0346	lactoylglutathione lyase activity
S101392_RS13890	COG5577	PFAM Coat F domain
S101392_RS13895	COG1063	alcohol dehydrogenase
S101392_RS13905	COG5577	PFAM Coat F domain
S101392_RS13910	COG0789	Transcriptional regulator
S101392_RS13920	COG1064	alcohol dehydrogenase
S101392_RS13925	COG0693	protein deglycase activity
S101392_RS13930	COG1621	beta-fructofuranosidase activity
S101392_RS13935	COG3716	PTS system mannose fructose sorbose family IID component
S101392_RS13940	COG3715	PTS system
S101392_RS13945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS13950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS13955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
S101392_RS13955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
S101392_RS13960	COG1113	amino acid transport
S101392_RS13965	COG1280	lysine exporter protein (LysE YggA)
S101392_RS13970	COG1378	Sugar-specific transcriptional regulator TrmB
S101392_RS13975	COG1595	DNA-templated transcription, initiation
S101392_RS13985	COG2755	lipolytic protein G-D-S-L family
S101392_RS13985	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
S101392_RS13995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101392_RS13995	COG2124	cytochrome p450
S101392_RS14000	COG1309	transcriptional regulator
S101392_RS14005	COG2226	methyltransferase
S101392_RS14015	COG2116	formate transmembrane transporter activity
S101392_RS14020	COG5609	conserved protein (DUF2294)
S101392_RS14025	COG3383	formate dehydrogenase (NAD+) activity
S101392_RS14030	COG2427	Protein of unknown function (DUF1641)
S101392_RS14040	COG0626	cystathionine gamma-synthase activity
S101392_RS14045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101392_RS14050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
S101392_RS14055	COG2226	methyltransferase
S101392_RS14070	COG0768	penicillin binding
S101392_RS14075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
S101392_RS14080	COG0572	uridine kinase
S101392_RS14085	COG0826	peptidase U32
S101392_RS14090	COG0826	peptidase U32
S101392_RS14095	COG4122	O-methyltransferase activity
S101392_RS14100	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
S101392_RS14105	COG3906	Belongs to the UPF0473 family
S101392_RS14110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
S101392_RS14115	COG4472	Bacterial protein of unknown function (DUF965)
S101392_RS14120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
S101392_RS14125	COG0628	permease
S101392_RS14130	COG1126	abc transporter atp-binding protein
S101392_RS14135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS14140	COG0765	amino acid transport
S101392_RS14145	COG0765	amino acid transport
S101392_RS14160	COG3881	PFAM PRC-barrel domain
S101392_RS14165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
S101392_RS14170	COG0457	Tetratricopeptide repeat
S101392_RS14175	COG0482	sulfurtransferase activity
S101392_RS14180	COG1104	cysteine desulfurase activity
S101392_RS14185	COG1959	2 iron, 2 sulfur cluster binding
S101392_RS14190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
S101392_RS14195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
S101392_RS14205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
S101392_RS14210	COG0124	histidyl-tRNA synthetase
S101392_RS14220	COG4991	sh3 domain protein
S101392_RS14220	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS14220	COG3103	Sh3 type 3 domain protein
S101392_RS14225	COG1490	D-aminoacyl-tRNA deacylase activity
S101392_RS14230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
S101392_RS14235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
S101392_RS14240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
S101392_RS14240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
S101392_RS14245	COG5416	Lipopolysaccharide assembly protein A domain
S101392_RS14250	COG0490	domain, Protein
S101392_RS14255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101392_RS14255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
S101392_RS14265	COG2244	polysaccharide biosynthetic process
S101392_RS14270	COG2323	membrane
S101392_RS14280	COG1862	Preprotein translocase
S101392_RS14285	COG0343	queuine tRNA-ribosyltransferase activity
S101392_RS14290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
S101392_RS14300	COG2255	four-way junction helicase activity
S101392_RS14305	COG0632	four-way junction helicase activity
S101392_RS14315	COG2814	Major facilitator Superfamily
S101392_RS14320	COG0673	inositol 2-dehydrogenase activity
S101392_RS14325	COG2112	serine threonine protein kinase
S101392_RS14340	COG1115	amino acid carrier protein
S101392_RS14345	COG0217	transcriptional regulatory protein
S101392_RS14355	COG1388	LysM domain
S101392_RS14360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
S101392_RS14365	COG0157	Belongs to the NadC ModD family
S101392_RS14370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
S101392_RS14375	COG1104	cysteine desulfurase activity
S101392_RS14380	COG1827	regulation of RNA biosynthetic process
S101392_RS14385	COG0077	Prephenate dehydratase
S101392_RS14390	COG4492	Belongs to the UPF0735 family
S101392_RS14395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
S101392_RS14400	COG3290	protein histidine kinase activity
S101392_RS14405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
S101392_RS14410	COG2868	ribosomal protein
S101392_RS14415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
S101392_RS14420	COG1994	Peptidase M50
S101392_RS14425	COG0739	heme binding
S101392_RS14430	COG2894	cell division
S101392_RS14435	COG0850	regulation of cytokinetic process
S101392_RS14440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
S101392_RS14450	COG1077	Cell shape determining protein MreB Mrl
S101392_RS14455	COG2003	Belongs to the UPF0758 family
S101392_RS14460	COG0424	maF-like protein
S101392_RS14470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
S101392_RS14475	COG0285	dihydrofolate synthase activity
S101392_RS14480	COG0525	valine-tRNA ligase activity
S101392_RS14490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101392_RS14495	COG1388	LysM domain
S101392_RS14500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
S101392_RS14505	COG0113	porphobilinogen synthase activity
S101392_RS14510	COG1587	Uroporphyrinogen-III synthase
S101392_RS14515	COG0181	hydroxymethylbilane synthase activity
S101392_RS14520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
S101392_RS14525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
S101392_RS14535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
S101392_RS14540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
S101392_RS14545	COG0470	DNA polymerase III
S101392_RS14545	COG1067	ATP-dependent peptidase activity
S101392_RS14550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
S101392_RS14555	COG0544	peptidyl-prolyl cis-trans isomerase activity
S101392_RS14560	COG1477	protein flavinylation
S101392_RS14560	COG0457	Tetratricopeptide repeat
S101392_RS14565	COG0066	3-isopropylmalate dehydratase activity
S101392_RS14570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
S101392_RS14575	COG0473	3-isopropylmalate dehydrogenase activity
S101392_RS14580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
S101392_RS14585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
S101392_RS14590	COG0440	acetolactate synthase activity
S101392_RS14595	COG0028	Belongs to the TPP enzyme family
S101392_RS14610	COG0454	-acetyltransferase
S101392_RS14615	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
S101392_RS14625	COG0622	Phosphoesterase
S101392_RS14630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
S101392_RS14635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
S101392_RS14640	COG5401	PFAM Sporulation and spore germination
S101392_RS14645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
S101392_RS14650	COG1846	Transcriptional regulator
S101392_RS14655	COG2197	response regulator
S101392_RS14660	COG0824	Thioesterase
S101392_RS14665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
S101392_RS14670	COG1053	succinate dehydrogenase
S101392_RS14675	COG2009	succinate dehydrogenase
S101392_RS14680	COG1719	4-vinyl reductase, 4VR
S101392_RS14685	COG0527	aspartate kinase activity
S101392_RS14695	COG0322	excinuclease ABC activity
S101392_RS14700	COG3118	belongs to the thioredoxin family
S101392_RS14710	COG3534	alpha-L-arabinofuranosidase
S101392_RS14715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
S101392_RS14720	COG2086	electron transfer activity
S101392_RS14725	COG1024	Enoyl-CoA hydratase
S101392_RS14730	COG1309	transcriptional regulator
S101392_RS14735	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS14745	COG3766	membrane
S101392_RS14750	COG1193	negative regulation of DNA recombination
S101392_RS14755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101392_RS14755	COG1796	DNA polymerase
S101392_RS14760	COG1286	toxin biosynthetic process
S101392_RS14765	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
S101392_RS14770	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
S101392_RS14775	COG0072	phenylalanine-tRNA ligase activity
S101392_RS14775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101392_RS14780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
S101392_RS14790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
S101392_RS14800	COG3835	regulator
S101392_RS14805	COG0277	FAD linked oxidase domain protein
S101392_RS14810	COG0247	lactate metabolic process
S101392_RS14815	COG0346	lactoylglutathione lyase activity
S101392_RS14825	COG1966	Carbon starvation protein
S101392_RS14830	COG3534	alpha-L-arabinofuranosidase
S101392_RS14835	COG0395	ABC-type sugar transport system, permease component
S101392_RS14840	COG1175	transmembrane transport
S101392_RS14845	COG1653	transport
S101392_RS14850	COG0371	Dehydrogenase
S101392_RS14855	COG0647	UMP catabolic process
S101392_RS14860	COG0235	Class ii aldolase
S101392_RS14865	COG1069	ribulokinase activity
S101392_RS14870	COG2160	L-arabinose isomerase activity
S101392_RS14875	COG3507	Belongs to the glycosyl hydrolase 43 family
S101392_RS14880	COG1363	Peptidase, m42
S101392_RS14890	COG3326	Membrane
S101392_RS14895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
S101392_RS14900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
S101392_RS14905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
S101392_RS14915	COG1346	cytolysis
S101392_RS14920	COG1380	Effector of murein hydrolase LrgA
S101392_RS14925	COG3279	Response regulator of the LytR AlgR family
S101392_RS14930	COG3275	phosphorelay sensor kinase activity
S101392_RS14935	COG1011	Hydrolase
S101392_RS14940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101392_RS14950	COG0398	Pfam SNARE associated Golgi protein
S101392_RS14955	COG1484	DNA-dependent DNA replication
S101392_RS14960	COG3611	Membrane attachment protein
S101392_RS14965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
S101392_RS14970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
S101392_RS14975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101392_RS14980	COG1733	regulation of RNA biosynthetic process
S101392_RS14985	COG2814	Major facilitator Superfamily
S101392_RS14990	COG0656	L-ascorbic acid biosynthetic process
S101392_RS14995	COG0237	dephospho-CoA kinase activity
S101392_RS15000	COG1971	Probably functions as a manganese efflux pump
S101392_RS15005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
S101392_RS15010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101392_RS15010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
S101392_RS15015	COG5002	protein histidine kinase activity
S101392_RS15020	COG0745	RESPONSE REGULATOR receiver
S101392_RS15030	COG0039	L-malate dehydrogenase activity
S101392_RS15035	COG0538	isocitrate dehydrogenase activity
S101392_RS15040	COG0372	Belongs to the citrate synthase family
S101392_RS15045	COG2707	UPF0756 membrane protein
S101392_RS15050	COG0628	permease
S101392_RS15055	COG3030	protein affecting phage T7 exclusion by the F plasmid
S101392_RS15060	COG0469	pyruvate kinase activity
S101392_RS15065	COG0205	6-phosphofructokinase activity
S101392_RS15070	COG0825	malonyl-CoA metabolic process
S101392_RS15075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
S101392_RS15080	COG0281	malic enzyme
S101392_RS15085	COG0587	DNA-directed DNA polymerase activity
S101392_RS15105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
S101392_RS15115	COG4109	DRTGG domain
S101392_RS15120	COG0730	response to heat
S101392_RS15125	COG1473	amidohydrolase
S101392_RS15130	COG0196	riboflavin kinase activity
S101392_RS15135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS15140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
S101392_RS15145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS15150	COG1126	abc transporter atp-binding protein
S101392_RS15155	COG0765	amino acid transport
S101392_RS15160	COG0765	amino acid transport
S101392_RS15165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS15170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS15175	COG0454	-acetyltransferase
S101392_RS15180	COG0583	DNA-binding transcription factor activity
S101392_RS15185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
S101392_RS15190	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS15200	COG0165	Argininosuccinate lyase
S101392_RS15205	COG0137	argininosuccinate synthase activity
S101392_RS15210	COG0521	Mo-molybdopterin cofactor biosynthetic process
S101392_RS15215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
S101392_RS15225	COG0827	DNA restriction-modification system
S101392_RS15230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
S101392_RS15235	COG3874	Sporulation protein YtfJ
S101392_RS15245	COG1714	RDD family
S101392_RS15250	COG0616	signal peptide processing
S101392_RS15255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
S101392_RS15260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
S101392_RS15265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101392_RS15275	COG0301	tRNA thio-modification
S101392_RS15280	COG1104	cysteine desulfurase activity
S101392_RS15285	COG1114	Component of the transport system for branched-chain amino acids
S101392_RS15290	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
S101392_RS15295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
S101392_RS15300	COG1309	transcriptional regulator
S101392_RS15305	COG1956	GAF domain-containing protein
S101392_RS15310	COG2199	diguanylate cyclase activity
S101392_RS15310	COG2203	Gaf domain
S101392_RS15320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
S101392_RS15325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101392_RS15335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
S101392_RS15340	COG0454	-acetyltransferase
S101392_RS15345	COG0517	IMP dehydrogenase activity
S101392_RS15350	COG0123	including yeast histone deacetylase and acetoin utilization protein
S101392_RS15355	COG1360	Flagellar Motor Protein
S101392_RS15360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
S101392_RS15365	COG1609	Transcriptional regulator
S101392_RS15370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
S101392_RS15370	COG1605	Chorismate mutase
S101392_RS15375	COG3118	belongs to the thioredoxin family
S101392_RS15380	COG4980	gas vesicle protein
S101392_RS15385	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
S101392_RS15390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
S101392_RS15395	COG1674	ftsk spoiiie
S101392_RS15400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
S101392_RS15405	COG4848	Belongs to the UPF0354 family
S101392_RS15410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS15420	COG1363	Peptidase, m42
S101392_RS15425	COG5584	Small secreted protein
S101392_RS15430	COG0281	malic enzyme
S101392_RS15435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS15440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
S101392_RS15450	COG0510	thiamine kinase activity
S101392_RS15455	COG1523	belongs to the glycosyl hydrolase 13 family
S101392_RS15460	COG1597	lipid kinase activity
S101392_RS15470	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
S101392_RS15475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
S101392_RS15480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101392_RS15485	COG2252	PERMEase
S101392_RS15490	COG4473	ABC transporter
S101392_RS15495	COG1131	(ABC) transporter
S101392_RS15500	COG1349	DNA-binding transcription factor activity
S101392_RS15505	COG1187	pseudouridine synthase activity
S101392_RS15510	COG2244	polysaccharide biosynthetic process
S101392_RS15515	COG2081	HI0933 family
S101392_RS15520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
S101392_RS15530	COG5578	integral membrane protein
S101392_RS15535	COG0673	inositol 2-dehydrogenase activity
S101392_RS15540	COG1653	transport
S101392_RS15545	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
S101392_RS15550	COG4209	transmembrane transport
S101392_RS15555	COG2207	Transcriptional regulator
S101392_RS15560	COG1653	transport
S101392_RS15565	COG0395	ABC-type sugar transport system, permease component
S101392_RS15570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101392_RS15575	COG2124	cytochrome p450
S101392_RS15580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
S101392_RS15590	COG0156	8-amino-7-oxononanoate synthase activity
S101392_RS15595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
S101392_RS15605	COG1073	alpha beta
S101392_RS15610	COG1609	Transcriptional regulator
S101392_RS15615	COG1653	transport
S101392_RS15620	COG1175	transmembrane transport
S101392_RS15625	COG0395	ABC-type sugar transport system, permease component
S101392_RS15630	COG1486	melibiose metabolic process
S101392_RS15635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
S101392_RS15640	COG0495	leucyl-tRNA aminoacylation
S101392_RS15650	COG2202	Pas domain
S101392_RS15650	COG1366	Belongs to the anti-sigma-factor antagonist family
S101392_RS15655	COG2814	Major facilitator Superfamily
S101392_RS15660	COG2433	Pfam Transposase IS66
S101392_RS15665	COG0577	efflux transmembrane transporter activity
S101392_RS15670	COG1136	(ABC) transporter
S101392_RS15675	COG2205	protein histidine kinase activity
S101392_RS15680	COG0745	RESPONSE REGULATOR receiver
S101392_RS15685	COG0577	efflux transmembrane transporter activity
S101392_RS15690	COG1136	(ABC) transporter
S101392_RS15705	COG1131	(ABC) transporter
S101392_RS15710	COG1725	Transcriptional regulator
S101392_RS15720	COG1242	4 iron, 4 sulfur cluster binding
S101392_RS15725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
S101392_RS15735	COG2267	carboxylic ester hydrolase activity
S101392_RS15740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
S101392_RS15745	COG1113	amino acid transport
S101392_RS15750	COG0367	asparagine synthase
S101392_RS15755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
S101392_RS15760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
S101392_RS15770	COG1506	peptidase
S101392_RS15775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
S101392_RS15780	COG1116	anion transmembrane transporter activity
S101392_RS15785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
S101392_RS15790	COG0494	nUDIX hydrolase
S101392_RS15795	COG4824	toxin secretion phage lysis holin
S101392_RS15800	COG0783	Belongs to the Dps family
S101392_RS15815	COG1854	S-ribosylhomocysteine lyase activity
S101392_RS15820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
S101392_RS15825	COG0288	reversible hydration of carbon dioxide
S101392_RS15830	COG0254	rRNA binding
S101392_RS15835	COG1271	oxidase subunit
S101392_RS15840	COG1294	oxidase, subunit
S101392_RS15850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101392_RS15855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
S101392_RS15855	COG1321	iron dependent repressor
S101392_RS15860	COG1121	(ABC) transporter
S101392_RS15865	COG0803	Belongs to the bacterial solute-binding protein 9 family
S101392_RS15870	COG4948	Mandelate Racemase Muconate Lactonizing
S101392_RS15875	COG0318	PFAM AMP-dependent synthetase and ligase
S101392_RS15880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
S101392_RS15885	COG0596	Alpha beta hydrolase
S101392_RS15890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
S101392_RS15895	COG1169	isochorismate synthase
S101392_RS15900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
S101392_RS15905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101392_RS15910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101392_RS15915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101392_RS15920	COG0438	transferase activity, transferring glycosyl groups
S101392_RS15930	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101392_RS15935	COG0438	transferase activity, transferring glycosyl groups
S101392_RS15940	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101392_RS15945	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
S101392_RS15950	COG0058	SHG alpha-glucan phosphorylase activity
S101392_RS15955	COG0297	glycogen (starch) synthase activity
S101392_RS15960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101392_RS15965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
S101392_RS15970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
S101392_RS16095	COG3859	Proton-coupled thiamine transporter YuaJ
S101392_RS16100	COG1247	-acetyltransferase
S101392_RS16105	COG2268	Band 7 protein
S101392_RS16110	COG1585	Membrane protein implicated in regulation of membrane protease activity
S101392_RS16115	COG2318	DinB family
S101392_RS16125	COG1454	alcohol dehydrogenase
S101392_RS16130	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS16135	COG1510	regulation of RNA biosynthetic process
S101392_RS16145	COG0569	domain protein
S101392_RS16150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
S101392_RS16155	COG4682	membrane
S101392_RS16160	COG1705	Flagellar rod assembly protein muramidase FlgJ
S101392_RS16165	COG0477	Major facilitator Superfamily
S101392_RS16170	COG5553	Cysteine dioxygenase type I
S101392_RS16180	COG1968	undecaprenyl-diphosphatase activity
S101392_RS16185	COG0628	permease
S101392_RS16190	COG0673	inositol 2-dehydrogenase activity
S101392_RS16195	COG4806	L-rhamnose isomerase
S101392_RS16200	COG3254	rhamnose metabolic process
S101392_RS16205	COG1070	Carbohydrate kinase
S101392_RS16210	COG1349	DNA-binding transcription factor activity
S101392_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS16215	COG3347	Dehydrogenase
S101392_RS16225	COG0840	transmembrane signaling receptor activity
S101392_RS16230	COG0840	transmembrane signaling receptor activity
S101392_RS16235	COG0840	transmembrane signaling receptor activity
S101392_RS16240	COG0840	transmembrane signaling receptor activity
S101392_RS16255	COG0432	Pfam Uncharacterised protein family UPF0047
S101392_RS16260	COG0366	Alpha amylase catalytic
S101392_RS16265	COG1253	flavin adenine dinucleotide binding
S101392_RS16270	COG2738	Putative neutral zinc metallopeptidase
S101392_RS16285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
S101392_RS16300	COG0166	Belongs to the GPI family
S101392_RS16305	COG1979	alcohol dehydrogenase
S101392_RS16310	COG1979	alcohol dehydrogenase
S101392_RS16315	COG2155	Conserved Protein
S101392_RS16320	COG1098	S1 RNA binding domain
S101392_RS16325	COG0436	Aminotransferase
S101392_RS16330	COG1522	sequence-specific DNA binding
S101392_RS16335	COG2267	carboxylic ester hydrolase activity
S101392_RS16345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
S101392_RS16350	COG2205	protein histidine kinase activity
S101392_RS16360	COG5018	Exonuclease
S101392_RS16370	COG2814	Major facilitator Superfamily
S101392_RS16375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101392_RS16380	COG3011	Protein conserved in bacteria
S101392_RS16390	COG3290	protein histidine kinase activity
S101392_RS16395	COG4565	transcriptional regulatory protein
S101392_RS16400	COG1744	ABC transporter substrate-binding protein PnrA-like
S101392_RS16405	COG3845	ABC transporter
S101392_RS16410	COG4603	Belongs to the binding-protein-dependent transport system permease family
S101392_RS16415	COG1079	Belongs to the binding-protein-dependent transport system permease family
S101392_RS16420	COG3493	citrate carrier protein
S101392_RS16430	COG2111	Na H antiporter
S101392_RS16430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
S101392_RS16435	COG2111	Na H antiporter
S101392_RS16440	COG1006	Multisubunit Na H antiporter MnhC subunit
S101392_RS16445	COG0651	ATP synthesis coupled electron transport
S101392_RS16450	COG1863	multisubunit Na H antiporter MnhE subunit
S101392_RS16455	COG2212	antiporter activity
S101392_RS16460	COG1320	monovalent cation:proton antiporter activity
S101392_RS16465	COG2050	protein possibly involved in aromatic compounds catabolism
S101392_RS16470	COG2197	response regulator
S101392_RS16475	COG4585	Histidine kinase
S101392_RS16485	COG0142	geranyltranstransferase activity
S101392_RS16500	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
S101392_RS16505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
S101392_RS16510	COG1335	isochorismatase
S101392_RS16515	COG5506	Protein of unknown function (DUF1694)
S101392_RS16530	COG0628	permease
S101392_RS16545	COG1418	mRNA catabolic process
S101392_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS16560	COG1511	domain protein
S101392_RS16565	COG0433	COG0433 Predicted ATPase
S101392_RS16565	COG1674	ftsk spoiiie
S101392_RS16570	COG4499	WXG100 protein secretion system (Wss), protein YukC
S101392_RS16575	COG5417	Belongs to the EsaB family
S101392_RS16580	COG4842	Belongs to the WXG100 family
S101392_RS16590	COG2508	Transcriptional regulator
S101392_RS16590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
S101392_RS16595	COG0686	Belongs to the AlaDH PNT family
S101392_RS16600	COG5634	Uncharacterized conserved protein (DUF2278)
S101392_RS16605	COG3251	PFAM MbtH domain protein
S101392_RS16610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS16615	COG1535	isochorismatase
S101392_RS16615	COG3433	isochorismatase activity
S101392_RS16620	COG1021	2,3-dihydroxybenzoate-AMP ligase
S101392_RS16625	COG1169	isochorismate synthase
S101392_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS16635	COG2819	hydrolase of the alpha beta superfamily
S101392_RS16640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
S101392_RS16645	COG1268	BioY protein
S101392_RS16650	COG2056	Na+-H+ antiporter family
S101392_RS16655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
S101392_RS16660	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
S101392_RS16665	COG3584	3D domain protein
S101392_RS16680	COG1252	NADH dehydrogenase
S101392_RS16685	COG0492	ferredoxin-NADP+ reductase activity
S101392_RS16695	COG0516	GMP reductase activity
S101392_RS16700	COG2808	Putative FMN-binding domain
S101392_RS16705	COG0456	acetyltransferase
S101392_RS16710	COG0316	Belongs to the HesB IscA family
S101392_RS16715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
S101392_RS16720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101392_RS16725	COG4844	belongs to the
S101392_RS16730	COG1252	NADH dehydrogenase
S101392_RS16735	COG4837	Protein of unknown function (DUF1462)
S101392_RS16740	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
S101392_RS16745	COG1506	peptidase
S101392_RS16745	COG0823	Involved in the tonB-independent uptake of proteins
S101392_RS16745	COG4946	Tricorn protease homolog
S101392_RS16750	COG0083	homoserine kinase activity
S101392_RS16755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
S101392_RS16760	COG0460	homoserine dehydrogenase
S101392_RS16765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
S101392_RS16770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
S101392_RS16775	COG0647	UMP catabolic process
S101392_RS16780	COG2445	Protein of unknown function DUF86
S101392_RS16785	COG4470	Protein conserved in bacteria
S101392_RS16795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
S101392_RS16800	COG0739	heme binding
S101392_RS16810	COG3377	Domain of unknown function (DUF1805)
S101392_RS16815	COG0737	Belongs to the 5'-nucleotidase family
S101392_RS16820	COG0730	response to heat
S101392_RS16825	COG1801	Protein of unknown function DUF72
S101392_RS16835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
S101392_RS16840	COG2508	Transcriptional regulator
S101392_RS16845	COG2233	PERMEase
S101392_RS16850	COG2233	PERMEase
S101392_RS16855	COG3648	Uricase
S101392_RS16855	COG3195	allantoin biosynthetic process
S101392_RS16860	COG2351	hydroxyisourate hydrolase activity
S101392_RS16870	COG2080	2 iron, 2 sulfur cluster binding
S101392_RS16875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
S101392_RS16880	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
S101392_RS16885	COG2068	MobA-Related Protein
S101392_RS16890	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
S101392_RS16895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
S101392_RS16900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
S101392_RS16910	COG2356	endonuclease I
S101392_RS16915	COG3842	ATPase activity
S101392_RS16920	COG2188	Transcriptional regulator
S101392_RS16925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101392_RS16930	COG0395	ABC-type sugar transport system, permease component
S101392_RS16935	COG1175	transmembrane transport
S101392_RS16940	COG1653	transport
S101392_RS16945	COG2222	sugar isomerase
S101392_RS16950	COG0322	excinuclease ABC activity
S101392_RS16955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
S101392_RS16970	COG0719	Fe-S assembly protein
S101392_RS16975	COG0822	iron-sulfur transferase activity
S101392_RS16980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
S101392_RS16985	COG0719	Fe-S assembly protein
S101392_RS16990	COG0396	ATPase activity
S101392_RS17005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
S101392_RS17010	COG1464	Belongs to the NlpA lipoprotein family
S101392_RS17015	COG2011	ABC-type metal ion transport system permease component
S101392_RS17020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
S101392_RS17030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
S101392_RS17035	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
S101392_RS17045	COG0509	glycine decarboxylation via glycine cleavage system
S101392_RS17050	COG1393	Belongs to the ArsC family
S101392_RS17055	COG1960	acyl-CoA dehydrogenase activity
S101392_RS17060	COG0183	Belongs to the thiolase family
S101392_RS17065	COG1250	3-hydroxyacyl-CoA dehydrogenase
S101392_RS17065	COG1024	Enoyl-CoA hydratase
S101392_RS17085	COG5577	PFAM Coat F domain
S101392_RS17090	COG1846	Transcriptional regulator
S101392_RS17095	COG0477	Major facilitator Superfamily
S101392_RS17100	COG1942	4-Oxalocrotonate Tautomerase
S101392_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS17110	COG0583	DNA-binding transcription factor activity
S101392_RS17120	COG1120	ATPase activity
S101392_RS17135	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS17140	COG0783	Belongs to the Dps family
S101392_RS17145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101392_RS17150	COG0745	RESPONSE REGULATOR receiver
S101392_RS17155	COG2770	Histidine kinase
S101392_RS17155	COG2205	protein histidine kinase activity
S101392_RS17165	COG1309	transcriptional regulator
S101392_RS17170	COG0114	fumarate hydratase activity
S101392_RS17180	COG0697	spore germination
S101392_RS17185	COG0814	amino acid
S101392_RS17195	COG2197	response regulator
S101392_RS17200	COG4585	Histidine kinase
S101392_RS17205	COG4758	membrane
S101392_RS17210	COG3595	metallopeptidase activity
S101392_RS17215	COG1842	Phage shock protein A
S101392_RS17220	COG4758	membrane
S101392_RS17225	COG2814	Major facilitator Superfamily
S101392_RS17230	COG2096	Adenosyltransferase
S101392_RS17235	COG1120	ATPase activity
S101392_RS17240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS17245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS17250	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS17255	COG3386	PFAM SMP-30 Gluconolaconase
S101392_RS17260	COG2205	protein histidine kinase activity
S101392_RS17265	COG0745	RESPONSE REGULATOR receiver
S101392_RS17275	COG1191	sigma factor activity
S101392_RS17285	COG2140	Oxalate decarboxylase
S101392_RS17295	COG0577	efflux transmembrane transporter activity
S101392_RS17300	COG1136	(ABC) transporter
S101392_RS17305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
S101392_RS17310	COG1120	ATPase activity
S101392_RS17315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
S101392_RS17325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS17330	COG0531	amino acid
S101392_RS17345	COG1988	membrane-bound metal-dependent
S101392_RS17350	COG1368	sulfuric ester hydrolase activity
S101392_RS17355	COG1910	domain protein
S101392_RS17360	COG0725	ABC transporter, periplasmic molybdate-binding protein
S101392_RS17365	COG4149	molybdate abc transporter
S101392_RS17370	COG0656	L-ascorbic acid biosynthetic process
S101392_RS17380	COG0025	NhaP-type Na H and K H
S101392_RS17385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
S101392_RS17390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
S101392_RS17395	COG3973	AAA domain
S101392_RS17405	COG2860	membrane
S101392_RS17410	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
S101392_RS17415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
S101392_RS17420	COG2217	Heavy metal translocating P-type atpase
S101392_RS17425	COG2217	Heavy metal translocating P-type atpase
S101392_RS17430	COG2608	mercury ion transmembrane transporter activity
S101392_RS17435	COG1937	Protein conserved in bacteria
S101392_RS17445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
S101392_RS17450	COG1289	transmembrane transporter activity
S101392_RS17460	COG2076	Multidrug Resistance protein
S101392_RS17465	COG1309	transcriptional regulator
S101392_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS17480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
S101392_RS17485	COG0557	exoribonuclease II activity
S101392_RS17490	COG1647	Serine aminopeptidase, S33
S101392_RS17495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
S101392_RS17500	COG0596	Alpha beta hydrolase
S101392_RS17505	COG1476	TRANSCRIPTIONal
S101392_RS17510	COG1396	sequence-specific DNA binding
S101392_RS17515	COG1396	sequence-specific DNA binding
S101392_RS17520	COG1733	regulation of RNA biosynthetic process
S101392_RS17525	COG0840	transmembrane signaling receptor activity
S101392_RS17530	COG1174	glycine betaine transport
S101392_RS17535	COG1732	Glycine betaine
S101392_RS17540	COG1174	glycine betaine transport
S101392_RS17545	COG0517	IMP dehydrogenase activity
S101392_RS17545	COG1125	glycine betaine transport
S101392_RS17550	COG1510	regulation of RNA biosynthetic process
S101392_RS17555	COG1174	glycine betaine transport
S101392_RS17560	COG1732	Glycine betaine
S101392_RS17565	COG1174	glycine betaine transport
S101392_RS17570	COG1125	glycine betaine transport
S101392_RS17570	COG0517	IMP dehydrogenase activity
S101392_RS17575	COG1510	regulation of RNA biosynthetic process
S101392_RS17580	COG2095	MarC family integral membrane protein
S101392_RS17590	COG3064	Membrane
S101392_RS17595	COG4640	response to antibiotic
S101392_RS17600	COG0456	acetyltransferase
S101392_RS17615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
S101392_RS17630	COG0436	Aminotransferase
S101392_RS17635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
S101392_RS17640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101392_RS17650	COG2234	aminopeptidase activity
S101392_RS17655	COG0148	phosphopyruvate hydratase activity
S101392_RS17660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
S101392_RS17665	COG0149	triose-phosphate isomerase activity
S101392_RS17670	COG0126	phosphoglycerate kinase activity
S101392_RS17675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
S101392_RS17680	COG2390	Transcriptional regulator
S101392_RS17685	COG2814	Major facilitator Superfamily
S101392_RS17690	COG1609	Transcriptional regulator
S101392_RS17695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS17705	COG0583	DNA-binding transcription factor activity
S101392_RS17710	COG0697	spore germination
S101392_RS17715	COG1113	amino acid transport
S101392_RS17720	COG3858	chitin binding
S101392_RS17725	COG1556	Lactate utilization protein
S101392_RS17730	COG1139	Iron-sulfur cluster binding protein
S101392_RS17735	COG0247	lactate metabolic process
S101392_RS17740	COG2197	response regulator
S101392_RS17745	COG4585	Histidine kinase
S101392_RS17750	COG0842	Transport permease protein
S101392_RS17755	COG1131	(ABC) transporter
S101392_RS17760	COG0596	Alpha beta hydrolase
S101392_RS17765	COG2208	phosphoserine phosphatase activity
S101392_RS17770	COG3867	Arabinogalactan endo-beta-1,4-galactanase
S101392_RS17775	COG1874	Beta-galactosidase
S101392_RS17780	COG3833	ABC-type maltose transport systems, permease component
S101392_RS17785	COG1175	transmembrane transport
S101392_RS17790	COG2182	Extracellular solute-binding protein
S101392_RS17795	COG1609	Transcriptional regulator
S101392_RS17800	COG2186	Transcriptional regulator
S101392_RS17805	COG1620	l-lactate permease
S101392_RS17810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
S101392_RS17820	COG5039	Polysaccharide pyruvyl transferase
S101392_RS17825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101392_RS17830	COG0110	maltose O-acetyltransferase activity
S101392_RS17835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
S101392_RS17840	COG2244	polysaccharide biosynthetic process
S101392_RS17845	COG1216	Glycosyl transferase, family 2
S101392_RS17850	COG5039	Polysaccharide pyruvyl transferase
S101392_RS17855	COG1216	Glycosyl transferase, family 2
S101392_RS17865	COG0438	transferase activity, transferring glycosyl groups
S101392_RS17870	COG1215	transferase activity, transferring glycosyl groups
S101392_RS17875	COG0438	transferase activity, transferring glycosyl groups
S101392_RS17880	COG1086	Polysaccharide biosynthesis protein
S101392_RS17885	COG0489	protein tyrosine kinase activity
S101392_RS17890	COG3944	biosynthesis protein
S101392_RS17895	COG1396	sequence-specific DNA binding
S101392_RS17900	COG2272	Belongs to the type-B carboxylesterase lipase family
S101392_RS17910	COG3479	Phenolic acid decarboxylase
S101392_RS17920	COG1794	racemase activity, acting on amino acids and derivatives
S101392_RS17925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
S101392_RS17930	COG1621	beta-fructofuranosidase activity
S101392_RS17935	COG1621	beta-fructofuranosidase activity
S101392_RS17940	COG0531	amino acid
S101392_RS17945	COG1309	transcriptional regulator
S101392_RS17950	COG2076	Multidrug Resistance protein
S101392_RS17955	COG2076	Multidrug Resistance protein
S101392_RS17965	COG0277	FAD linked oxidase domain protein
S101392_RS17970	COG3621	Patatin-like phospholipase
S101392_RS17980	COG0740	serine-type endopeptidase activity
S101392_RS17985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
S101392_RS17990	COG0366	Alpha amylase catalytic
S101392_RS17995	COG1554	hydrolase, family 65, central catalytic
S101392_RS18000	COG5521	maltodextrose utilization protein MalA
S101392_RS18005	COG3833	ABC-type maltose transport systems, permease component
S101392_RS18010	COG1175	transmembrane transport
S101392_RS18015	COG2182	Extracellular solute-binding protein
S101392_RS18025	COG1609	Transcriptional regulator
S101392_RS18030	COG1611	Belongs to the LOG family
S101392_RS18035	COG1694	Mazg nucleotide pyrophosphohydrolase
S101392_RS18040	COG0659	secondary active sulfate transmembrane transporter activity
S101392_RS18045	COG0288	reversible hydration of carbon dioxide
S101392_RS18050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
S101392_RS18055	COG0577	efflux transmembrane transporter activity
S101392_RS18060	COG1136	(ABC) transporter
S101392_RS18065	COG5002	protein histidine kinase activity
S101392_RS18070	COG0745	RESPONSE REGULATOR receiver
S101392_RS18080	COG2162	N-hydroxyarylamine O-acetyltransferase activity
S101392_RS18085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS18090	COG1481	regulation of sporulation
S101392_RS18095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
S101392_RS18100	COG1660	Displays ATPase and GTPase activities
S101392_RS18105	COG1051	belongs to the nudix hydrolase family
S101392_RS18110	COG0492	ferredoxin-NADP+ reductase activity
S101392_RS18115	COG0791	NLP P60 protein
S101392_RS18115	COG3883	PFAM NLP P60 protein
S101392_RS18120	COG0457	Tetratricopeptide repeat
S101392_RS18125	COG1132	(ABC) transporter
S101392_RS18145	COG0140	phosphoribosyl-ATP diphosphatase activity
S101392_RS18145	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
S101392_RS18150	COG0107	imidazoleglycerol-phosphate synthase activity
S101392_RS18155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
S101392_RS18160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
S101392_RS18165	COG0131	Imidazoleglycerol-phosphate dehydratase
S101392_RS18170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
S101392_RS18175	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
S101392_RS18180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
S101392_RS18185	COG4990	cell redox homeostasis
S101392_RS18190	COG5297	Belongs to the glycosyl hydrolase family 6
S101392_RS18195	COG0110	maltose O-acetyltransferase activity
S101392_RS18200	COG0546	phosphoglycolate phosphatase activity
S101392_RS18205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
S101392_RS18210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
S101392_RS18215	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
S101392_RS18220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
S101392_RS18225	COG0363	glucosamine-6-phosphate deaminase activity
S101392_RS18230	COG2188	Transcriptional regulator
S101392_RS18235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
S101392_RS18240	COG1950	PFAM Membrane protein of
S101392_RS18245	COG1983	PspC domain protein
S101392_RS18250	COG3595	metallopeptidase activity
S101392_RS18265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101392_RS18270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
S101392_RS18275	COG0556	nucleotide-excision repair
S101392_RS18280	COG4897	Protein conserved in bacteria
S101392_RS18285	COG3848	Pyruvate phosphate dikinase
S101392_RS18285	COG0574	Belongs to the PEP-utilizing enzyme family
S101392_RS18290	COG1309	transcriptional regulator
S101392_RS18295	COG2814	Major facilitator Superfamily
S101392_RS18300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101392_RS18310	COG0793	Belongs to the peptidase S41A family
S101392_RS18310	COG3409	Peptidoglycan-binding domain 1 protein
S101392_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
S101392_RS18320	COG2884	Cell division ATP-binding protein ftsE
S101392_RS18325	COG2010	Cytochrome c
S101392_RS18330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS18340	COG0653	protein targeting
S101392_RS18345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
S101392_RS18360	COG1516	flagellar protein fliS
S101392_RS18365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
S101392_RS18370	COG1334	flagellar protein FlaG
S101392_RS18375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101392_RS18380	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
S101392_RS18385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
S101392_RS18395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
S101392_RS18400	COG4786	Flagellar basal body rod
S101392_RS18400	COG1256	bacterial-type flagellum assembly
S101392_RS18405	COG3418	PFAM FlgN family protein
S101392_RS18410	COG2747	anti-sigma28 factor FlgM
S101392_RS18420	COG1040	competence protein
S101392_RS18430	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
S101392_RS18435	COG1307	EDD domain protein, DegV family
S101392_RS18440	COG2197	response regulator
S101392_RS18445	COG4585	Histidine kinase
S101392_RS18450	COG1739	Uncharacterized protein family UPF0029
S101392_RS18455	COG1316	TRANSCRIPTIONal
S101392_RS18460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
S101392_RS18465	COG0438	transferase activity, transferring glycosyl groups
S101392_RS18470	COG1215	transferase activity, transferring glycosyl groups
S101392_RS18475	COG3206	protein involved in exopolysaccharide biosynthesis
S101392_RS18480	COG3307	-O-antigen
S101392_RS18485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101392_RS18490	COG0297	glycogen (starch) synthase activity
S101392_RS18490	COG0438	transferase activity, transferring glycosyl groups
S101392_RS18495	COG2244	polysaccharide biosynthetic process
S101392_RS18510	COG2247	cell wall binding repeat
S101392_RS18510	COG0860	N-Acetylmuramoyl-L-alanine amidase
S101392_RS18515	COG2385	sporulation resulting in formation of a cellular spore
S101392_RS18515	COG2247	cell wall binding repeat
S101392_RS18525	COG1316	TRANSCRIPTIONal
S101392_RS18530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
S101392_RS18550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
S101392_RS18555	COG1134	teichoic acid transport
S101392_RS18560	COG1682	transport, permease protein
S101392_RS18565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101392_RS18565	COG1215	transferase activity, transferring glycosyl groups
S101392_RS18570	COG0463	Glycosyl transferase, family 2
S101392_RS18615	COG4193	domain, Protein
S101392_RS18620	COG1482	cell wall glycoprotein biosynthetic process
S101392_RS18625	COG0697	spore germination
S101392_RS18630	COG0814	amino acid
S101392_RS18640	COG2814	Major facilitator Superfamily
S101392_RS18645	COG1316	TRANSCRIPTIONal
S101392_RS18650	COG0561	phosphatase activity
S101392_RS18655	COG0791	NLP P60 protein
S101392_RS18665	COG2843	Capsule synthesis protein
S101392_RS18675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
S101392_RS18685	COG1609	Transcriptional regulator
S101392_RS18690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101392_RS18695	COG1869	D-ribose catabolic process
S101392_RS18700	COG1129	ABC transporter
S101392_RS18705	COG1172	Belongs to the binding-protein-dependent transport system permease family
S101392_RS18710	COG1879	ABC-type sugar transport system periplasmic component
S101392_RS18715	COG3103	Sh3 type 3 domain protein
S101392_RS18725	COG2249	NAD(P)H dehydrogenase (quinone) activity
S101392_RS18730	COG3527	Alpha-acetolactate decarboxylase
S101392_RS18735	COG0028	Belongs to the TPP enzyme family
S101392_RS18740	COG0583	DNA-binding transcription factor activity
S101392_RS18745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
S101392_RS18760	COG5337	Spore coat protein CotH
S101392_RS18770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
S101392_RS18780	COG0405	Gamma-glutamyltransferase
S101392_RS18785	COG1522	sequence-specific DNA binding
S101392_RS18790	COG2059	Chromate
S101392_RS18795	COG2059	Chromate
S101392_RS18805	COG0655	NAD(P)H dehydrogenase (quinone) activity
S101392_RS18810	COG0583	DNA-binding transcription factor activity
S101392_RS18825	COG5444	nuclease activity
S101392_RS18840	COG3878	Protein conserved in bacteria
S101392_RS18845	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
S101392_RS18850	COG4464	protein tyrosine phosphatase activity
S101392_RS18855	COG0489	protein tyrosine kinase activity
S101392_RS18860	COG3944	biosynthesis protein
S101392_RS18870	COG4715	Zinc finger, swim domain protein
S101392_RS18875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
S101392_RS18880	COG0561	phosphatase activity
S101392_RS18885	COG1349	DNA-binding transcription factor activity
S101392_RS18890	COG0629	single-stranded DNA binding
S101392_RS18905	COG3764	Sortase (surface protein transpeptidase)
S101392_RS18915	COG3279	Response regulator of the LytR AlgR family
S101392_RS18920	COG2972	Histidine kinase
S101392_RS18920	COG0745	RESPONSE REGULATOR receiver
S101392_RS18925	COG1970	mechanosensitive ion channel activity
S101392_RS18930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
S101392_RS18935	COG0457	Tetratricopeptide repeat
S101392_RS18940	COG4786	Flagellar basal body rod
S101392_RS18945	COG4786	Flagellar basal body rod
S101392_RS18950	COG1077	Cell shape determining protein MreB Mrl
S101392_RS18955	COG1609	Transcriptional regulator
S101392_RS18965	COG1846	Transcriptional regulator
S101392_RS18970	COG2814	Major facilitator Superfamily
S101392_RS18975	COG3420	alginic acid biosynthetic process
S101392_RS18980	COG1953	Uracil, thiamine, allantoin
S101392_RS18985	COG0477	Major facilitator Superfamily
S101392_RS18990	COG1335	isochorismatase
S101392_RS19000	COG0004	ammonium transporteR
S101392_RS19005	COG0347	Belongs to the P(II) protein family
S101392_RS19010	COG0671	phosphoesterase, PA-phosphatase related
S101392_RS19020	COG0739	heme binding
S101392_RS19025	COG1247	-acetyltransferase
S101392_RS19040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101392_RS19045	COG0789	Transcriptional regulator
S101392_RS19055	COG2910	NAD(P)H-binding
S101392_RS19060	COG1959	2 iron, 2 sulfur cluster binding
S101392_RS19065	COG0804	urea catabolic process
S101392_RS19070	COG0832	Belongs to the urease beta subunit family
S101392_RS19075	COG0831	urea catabolic process
S101392_RS19090	COG3237	CsbD-like
S101392_RS19095	COG1994	Peptidase M50
S101392_RS19100	COG0457	Tetratricopeptide repeat
S101392_RS19110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
S101392_RS19115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
S101392_RS19125	COG2304	oxidoreductase activity
S101392_RS19135	COG2304	oxidoreductase activity
S101392_RS19140	COG2385	sporulation resulting in formation of a cellular spore
S101392_RS19145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101392_RS19155	COG4836	Membrane
S101392_RS19165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
S101392_RS19170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
S101392_RS19175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
S101392_RS19180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
S101392_RS19185	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
S101392_RS19190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
S101392_RS19200	COG0356	it plays a direct role in the translocation of protons across the membrane
S101392_RS19210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
S101392_RS19215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
S101392_RS19220	COG4475	Protein of unknown function (DUF436)
S101392_RS19225	COG0698	ribose 5-phosphate isomerase
S101392_RS19230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
S101392_RS19235	COG1971	Probably functions as a manganese efflux pump
S101392_RS19240	COG0009	L-threonylcarbamoyladenylate synthase
S101392_RS19245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
S101392_RS19265	COG2890	protein-(glutamine-N5) methyltransferase activity
S101392_RS19270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
S101392_RS19275	COG0346	lactoylglutathione lyase activity
S101392_RS19280	COG0789	Transcriptional regulator
S101392_RS19285	COG0679	Auxin Efflux Carrier
S101392_RS19290	COG0281	malic enzyme
S101392_RS19295	COG1435	thymidine kinase activity
S101392_RS19305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
S101392_RS19310	COG1494	fructose-1,6-bisphosphatase
S101392_RS19315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
S101392_RS19320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
S101392_RS19325	COG0191	fructose-bisphosphate aldolase activity
S101392_RS19330	COG2204	response regulator
S101392_RS19335	COG4821	SIS domain
S101392_RS19340	COG0504	CTP synthase activity
S101392_RS19345	COG3343	RNA polymerase activity
S101392_RS19350	COG1960	acyl-CoA dehydrogenase activity
S101392_RS19355	COG2181	nitrate reductase activity
S101392_RS19355	COG0247	lactate metabolic process
S101392_RS19360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101392_RS19365	COG4294	response to UV
S101392_RS19375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101392_RS19380	COG1132	(ABC) transporter
S101392_RS19385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
S101392_RS19390	COG2181	nitrate reductase activity
S101392_RS19395	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
S101392_RS19400	COG1140	nitrate reductase beta subunit
S101392_RS19405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
S101392_RS19410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101392_RS19420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
S101392_RS19425	COG2223	nitrite transmembrane transporter activity
S101392_RS19430	COG0018	arginyl-trna synthetase
S101392_RS19435	COG4506	Protein conserved in bacteria
S101392_RS19450	COG0535	radical SAM domain protein
S101392_RS19460	COG1131	(ABC) transporter
S101392_RS19465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
S101392_RS19470	COG0612	Peptidase, M16
S101392_RS19475	COG0612	Peptidase, M16
S101392_RS19485	COG3391	amine dehydrogenase activity
S101392_RS19490	COG3391	amine dehydrogenase activity
S101392_RS19500	COG0457	Tetratricopeptide repeat
S101392_RS19530	COG1131	(ABC) transporter
S101392_RS19540	COG0010	Belongs to the arginase family
S101392_RS19545	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
S101392_RS19550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
S101392_RS19565	COG1994	Peptidase M50
S101392_RS19570	COG1942	4-Oxalocrotonate Tautomerase
S101392_RS19575	COG1846	Transcriptional regulator
S101392_RS19580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
S101392_RS19585	COG0477	Major facilitator Superfamily
S101392_RS19590	COG1959	2 iron, 2 sulfur cluster binding
S101392_RS19595	COG3465	dGTPase activity
S101392_RS19600	COG1078	dGTPase activity
S101392_RS19605	COG4844	belongs to the
S101392_RS19615	COG0697	spore germination
S101392_RS19620	COG0095	Lipoate-protein ligase
S101392_RS19625	COG0583	DNA-binding transcription factor activity
S101392_RS19630	COG0280	phosphate acetyltransferase
S101392_RS19635	COG3253	May function as heme-dependent peroxidase
S101392_RS19640	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS19645	COG0436	Aminotransferase
S101392_RS19650	COG2814	Major facilitator Superfamily
S101392_RS19655	COG0151	Belongs to the GarS family
S101392_RS19660	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS19665	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS19670	COG0077	Prephenate dehydratase
S101392_RS19675	COG2814	Major facilitator Superfamily
S101392_RS19680	COG0833	amino acid
S101392_RS19685	COG4187	Peptidase family M20/M25/M40
S101392_RS19690	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS19695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
S101392_RS19705	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
S101392_RS19710	COG1091	dTDP-4-dehydrorhamnose reductase activity
S101392_RS19715	COG1088	dTDP-glucose 4,6-dehydratase activity
S101392_RS19720	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
S101392_RS19725	COG3980	spore coat polysaccharide biosynthesis protein
S101392_RS19730	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
S101392_RS19735	COG2089	acid synthase
S101392_RS19740	COG0456	acetyltransferase
S101392_RS19745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
S101392_RS19750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
S101392_RS19755	COG0463	Glycosyl transferase, family 2
S101392_RS19770	COG2363	Small membrane protein
S101392_RS19775	COG2233	PERMEase
S101392_RS19785	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS19790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
S101392_RS19795	COG1216	Glycosyl transferase, family 2
S101392_RS19810	COG1695	Transcriptional regulator
S101392_RS19815	COG0351	phosphomethylpyrimidine kinase
S101392_RS19825	COG1621	beta-fructofuranosidase activity
S101392_RS19830	COG1263	PTS System
S101392_RS19830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS19835	COG2116	formate transmembrane transporter activity
S101392_RS19840	COG3711	transcriptional antiterminator
S101392_RS19850	COG1404	Belongs to the peptidase S8 family
S101392_RS19855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS19860	COG0778	Nitroreductase
S101392_RS19865	COG0772	Belongs to the SEDS family
S101392_RS19875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
S101392_RS19880	COG1845	cytochrome c oxidase, subunit III
S101392_RS19885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
S101392_RS19890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
S101392_RS19895	COG2261	transglycosylase associated protein
S101392_RS19900	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
S101392_RS19905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
S101392_RS19910	COG2246	polysaccharide biosynthetic process
S101392_RS19915	COG1309	transcriptional regulator
S101392_RS19925	COG3162	membrane
S101392_RS19930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
S101392_RS19935	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
S101392_RS19940	COG2837	iron assimilation
S101392_RS19945	COG2822	iron ion transport
S101392_RS19950	COG0672	)-iron permease
S101392_RS19955	COG0352	thiamine-phosphate diphosphorylase activity
S101392_RS19960	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
S101392_RS19965	COG0583	DNA-binding transcription factor activity
S101392_RS19970	COG1380	Effector of murein hydrolase LrgA
S101392_RS19975	COG1346	cytolysis
S101392_RS19980	COG2814	Major facilitator Superfamily
S101392_RS19985	COG4895	conserved protein (DUF2196)
S101392_RS19990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
S101392_RS19995	COG0346	lactoylglutathione lyase activity
S101392_RS20005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101392_RS20010	COG1404	Belongs to the peptidase S8 family
S101392_RS20015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS20015	COG1263	PTS System
S101392_RS20020	COG3711	transcriptional antiterminator
S101392_RS20025	COG1442	glycosyl transferase family 8
S101392_RS20030	COG5522	Integral membrane protein (intg_mem_TP0381)
S101392_RS20035	COG1846	Transcriptional regulator
S101392_RS20040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
S101392_RS20045	COG2234	aminopeptidase activity
S101392_RS20060	COG2814	Major facilitator Superfamily
S101392_RS20065	COG2357	RelA SpoT domain protein
S101392_RS20070	COG1575	Belongs to the MenA family. Type 1 subfamily
S101392_RS20085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
S101392_RS20090	COG1696	Membrane protein involved in D-alanine export
S101392_RS20095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
S101392_RS20100	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
S101392_RS20105	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
S101392_RS20110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
S101392_RS20115	COG1486	melibiose metabolic process
S101392_RS20120	COG1447	Phosphotransferase system cellobiose-specific component IIA
S101392_RS20125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101392_RS20130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
S101392_RS20135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
S101392_RS20135	COG3711	transcriptional antiterminator
S101392_RS20145	COG2094	Belongs to the DNA glycosylase MPG family
S101392_RS20150	COG0753	catalase activity
S101392_RS20155	COG2814	Major facilitator Superfamily
S101392_RS20160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
S101392_RS20165	COG1131	(ABC) transporter
S101392_RS20185	COG1595	DNA-templated transcription, initiation
S101392_RS20190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
S101392_RS20195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
S101392_RS20200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
S101392_RS20205	COG4988	ABC transporter
S101392_RS20210	COG1294	oxidase, subunit
S101392_RS20215	COG1271	oxidase subunit
S101392_RS20220	COG3493	citrate carrier protein
S101392_RS20225	COG0501	Belongs to the peptidase M48B family
S101392_RS20235	COG0726	polysaccharide deacetylase
S101392_RS20240	COG3842	ATPase activity
S101392_RS20245	COG2508	Transcriptional regulator
S101392_RS20250	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS20255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
S101392_RS20265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
S101392_RS20270	COG1881	PFAM PEBP family protein
S101392_RS20275	COG0583	DNA-binding transcription factor activity
S101392_RS20285	COG4585	Histidine kinase
S101392_RS20290	COG2197	response regulator
S101392_RS20295	COG2195	Cleaves the N-terminal amino acid of tripeptides
S101392_RS20305	COG4894	glucomannan catabolic process
S101392_RS20310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101392_RS20315	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
S101392_RS20320	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS20325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
S101392_RS20330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
S101392_RS20335	COG2610	gluconate transmembrane transporter activity
S101392_RS20340	COG0500	methyltransferase
S101392_RS20345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101392_RS20360	COG0693	protein deglycase activity
S101392_RS20360	COG0753	catalase activity
S101392_RS20365	COG2851	Citrate transporter
S101392_RS20370	COG2273	Hydrolase Family 16
S101392_RS20375	COG3711	transcriptional antiterminator
S101392_RS20385	COG2270	Major facilitator Superfamily
S101392_RS20390	COG0513	Belongs to the DEAD box helicase family
S101392_RS20395	COG3401	FG-GAP repeat protein
S101392_RS20395	COG2755	lipolytic protein G-D-S-L family
S101392_RS20435	COG0589	response to stress
S101392_RS20440	COG2723	6-phospho-beta-galactosidase activity
S101392_RS20445	COG1263	PTS System
S101392_RS20445	COG2190	(PTS) system
S101392_RS20445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS20460	COG5444	nuclease activity
S101392_RS20475	COG3507	Belongs to the glycosyl hydrolase 43 family
S101392_RS20485	COG2986	histidine ammonia-lyase
S101392_RS20490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
S101392_RS20495	COG1228	amidohydrolase
S101392_RS20500	COG0010	Belongs to the arginase family
S101392_RS20505	COG0833	amino acid
S101392_RS20510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
S101392_RS20515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
S101392_RS20520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
S101392_RS20525	COG2390	Transcriptional regulator
S101392_RS20535	COG3192	ethanolamine utilization protein
S101392_RS20540	COG2079	MmgE PrpD family protein
S101392_RS20545	COG1473	amidohydrolase
S101392_RS20550	COG1126	abc transporter atp-binding protein
S101392_RS20555	COG0765	amino acid transport
S101392_RS20560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
S101392_RS20565	COG0456	acetyltransferase
S101392_RS20570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
S101392_RS20575	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
S101392_RS20580	COG0561	phosphatase activity
S101392_RS20610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
S101392_RS20615	COG5294	Protein conserved in bacteria
S101392_RS20620	COG0577	efflux transmembrane transporter activity
S101392_RS20625	COG1136	(ABC) transporter
S101392_RS20630	COG2205	protein histidine kinase activity
S101392_RS20635	COG0745	RESPONSE REGULATOR receiver
S101392_RS20640	COG0191	fructose-bisphosphate aldolase activity
S101392_RS20645	COG1082	Xylose isomerase domain protein TIM barrel
S101392_RS20650	COG1082	Xylose isomerase domain protein TIM barrel
S101392_RS20655	COG0673	inositol 2-dehydrogenase activity
S101392_RS20660	COG2814	Major facilitator Superfamily
S101392_RS20665	COG1082	Xylose isomerase domain protein TIM barrel
S101392_RS20670	COG3962	Belongs to the TPP enzyme family
S101392_RS20675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
S101392_RS20685	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS20690	COG1349	DNA-binding transcription factor activity
S101392_RS20695	COG0667	Aldo Keto reductase
S101392_RS20710	COG2814	Major facilitator Superfamily
S101392_RS20715	COG0326	Molecular chaperone. Has ATPase activity
S101392_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS20730	COG1309	transcriptional regulator
S101392_RS20735	COG1012	belongs to the aldehyde dehydrogenase family
S101392_RS20745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
S101392_RS20755	COG1714	RDD family
S101392_RS20760	COG2311	Membrane
S101392_RS20765	COG1917	Cupin 2, conserved barrel domain protein
S101392_RS20770	COG1309	transcriptional regulator
S101392_RS20775	COG1028	Short-chain dehydrogenase reductase Sdr
S101392_RS20780	COG1846	Transcriptional regulator
S101392_RS20785	COG1380	Effector of murein hydrolase LrgA
S101392_RS20790	COG1346	cytolysis
S101392_RS20795	COG5039	Polysaccharide pyruvyl transferase
S101392_RS20800	COG1929	Belongs to the glycerate kinase type-1 family
S101392_RS20805	COG1802	Transcriptional regulator
S101392_RS20810	COG1070	Carbohydrate kinase
S101392_RS20815	COG2610	gluconate transmembrane transporter activity
S101392_RS20820	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
S101392_RS20825	COG0450	alkyl hydroperoxide reductase
S101392_RS20830	COG3634	alkyl hydroperoxide reductase activity
S101392_RS20835	COG2723	6-phospho-beta-galactosidase activity
S101392_RS20840	COG2190	(PTS) system
S101392_RS20845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
S101392_RS20845	COG2190	(PTS) system
S101392_RS20845	COG1263	PTS System
S101392_RS20850	COG2188	Transcriptional regulator
S101392_RS20860	COG1131	(ABC) transporter
S101392_RS20865	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
S101392_RS20880	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
S101392_RS20895	COG1063	alcohol dehydrogenase
S101392_RS20915	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
S101392_RS20920	COG0456	acetyltransferase
S101392_RS20925	COG0457	Tetratricopeptide repeat
S101392_RS20935	COG0010	Belongs to the arginase family
S101392_RS20940	COG0833	amino acid
S101392_RS20945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
S101392_RS20950	COG3829	transcription factor binding
S101392_RS20955	COG5002	protein histidine kinase activity
S101392_RS20960	COG0745	RESPONSE REGULATOR receiver
S101392_RS20975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
S101392_RS20980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
S101392_RS20985	COG4853	Protein conserved in bacteria
S101392_RS20990	COG4863	YycH protein
S101392_RS20995	COG5002	protein histidine kinase activity
S101392_RS21000	COG0745	RESPONSE REGULATOR receiver
S101392_RS21030	COG0346	lactoylglutathione lyase activity
S101392_RS21035	COG0305	Participates in initiation and elongation during chromosome replication
S101392_RS21050	COG3093	addiction module antidote protein HigA
S101392_RS21055	COG2807	transmembrane transport
S101392_RS21060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
S101392_RS21065	COG0359	binds to the 23S rRNA
S101392_RS21070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
S101392_RS21075	COG4241	membrane
S101392_RS21085	COG5577	PFAM Coat F domain
S101392_RS21090	COG1733	regulation of RNA biosynthetic process
S101392_RS21095	COG1227	inorganic diphosphatase activity
S101392_RS21110	COG2271	Major facilitator Superfamily
S101392_RS21115	COG4978	Transcriptional regulator
S101392_RS21115	COG0789	Transcriptional regulator
S101392_RS21125	COG4319	ketosteroid isomerase
S101392_RS21130	COG1357	PFAM Pentapeptide repeats (8 copies)
S101392_RS21135	COG2814	Major facilitator Superfamily
S101392_RS21140	COG0583	DNA-binding transcription factor activity
S101392_RS21145	COG2153	protein acetylation
S101392_RS21155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
S101392_RS21160	COG1846	Transcriptional regulator
S101392_RS21165	COG2153	protein acetylation
S101392_RS21170	COG2364	Membrane
S101392_RS21175	COG0456	acetyltransferase
S101392_RS21180	COG2315	Protein conserved in bacteria
S101392_RS21185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
S101392_RS21205	COG0542	response to heat
S101392_RS21215	COG1331	Highly conserved protein containing a thioredoxin domain
S101392_RS21220	COG1266	CAAX protease self-immunity
S101392_RS21225	COG2814	Major facilitator Superfamily
S101392_RS21225	COG0477	Major facilitator Superfamily
S101392_RS21230	COG0110	maltose O-acetyltransferase activity
S101392_RS21235	COG0346	lactoylglutathione lyase activity
S101392_RS21240	COG1609	Transcriptional regulator
S101392_RS21245	COG0708	Exodeoxyribonuclease III
S101392_RS21250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
S101392_RS21255	COG0629	single-stranded DNA binding
S101392_RS21260	COG0360	Binds together with S18 to 16S ribosomal RNA
S101392_RS21265	COG0012	GTP binding
S101392_RS21270	COG0243	molybdopterin cofactor binding
S101392_RS21275	COG4481	Protein conserved in bacteria
S101392_RS21280	COG3949	Membrane
S101392_RS21290	COG1475	DNA binding
S101392_RS21295	COG1192	Involved in chromosome partitioning
S101392_RS21305	COG1475	DNA binding
S101392_RS21310	COG0357	Ribosomal RNA small subunit methyltransferase G
S101392_RS21315	COG0445	tRNA wobble uridine modification
S101392_RS21320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
S101392_RS21325	COG1847	R3H domain protein
S101392_RS21330	COG0706	membrane insertase activity
S101392_RS21335	COG0594	ribonuclease P activity