locus-tag	class	description
HC658_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC658_RS00010	COG0592	DNA-directed DNA polymerase activity
HC658_RS00015	COG2501	S4 domain
HC658_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC658_RS00030	COG0187	DNA topoisomerase II activity
HC658_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC658_RS00070	COG0517	IMP dehydrogenase activity
HC658_RS00070	COG0516	GMP reductase activity
HC658_RS00075	COG1686	Belongs to the peptidase S11 family
HC658_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HC658_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HC658_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC658_RS00100	COG1428	Deoxynucleoside kinase
HC658_RS00105	COG1428	Deoxynucleoside kinase
HC658_RS00110	COG3858	chitin binding
HC658_RS00110	COG1388	LysM domain
HC658_RS00120	COG0590	tRNA wobble adenosine to inosine editing
HC658_RS00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC658_RS00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC658_RS00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC658_RS00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HC658_RS00190	COG3853	Toxic anion resistance protein (TelA)
HC658_RS00195	COG1982	Orn Lys Arg decarboxylase major
HC658_RS00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC658_RS00205	COG3870	Protein conserved in bacteria
HC658_RS00210	COG1728	Protein conserved in bacteria
HC658_RS00215	COG0470	DNA polymerase III
HC658_RS00220	COG1774	PSP1 C-terminal conserved region
HC658_RS00225	COG4467	Involved in initiation control of chromosome replication
HC658_RS00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC658_RS00235	COG2827	Endonuclease containing a URI domain
HC658_RS00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HC658_RS00245	COG2002	toxin-antitoxin pair type II binding
HC658_RS00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_RS00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_RS00255	COG0084	hydrolase, TatD family'
HC658_RS00260	COG3584	3D domain protein
HC658_RS00260	COG3583	domain protein
HC658_RS00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC658_RS00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC658_RS00280	COG4466	Protein conserved in bacteria
HC658_RS00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC658_RS00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_RS00300	COG0251	oxidation-reduction process
HC658_RS00305	COG2088	sporulation resulting in formation of a cellular spore
HC658_RS00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC658_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC658_RS00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC658_RS00325	COG0193	aminoacyl-tRNA hydrolase activity
HC658_RS00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC658_RS00340	COG2002	toxin-antitoxin pair type II binding
HC658_RS00345	COG2244	polysaccharide biosynthetic process
HC658_RS00350	COG3956	TIGRFAM MazG family protein
HC658_RS00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC658_RS00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HC658_RS00375	COG1098	S1 RNA binding domain
HC658_RS00390	COG2208	phosphoserine phosphatase activity
HC658_RS00395	COG2304	oxidoreductase activity
HC658_RS00400	COG0515	serine threonine protein kinase
HC658_RS00405	COG0037	tRNA processing
HC658_RS00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC658_RS00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HC658_RS00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC658_RS00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC658_RS00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_RS00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC658_RS00445	COG0512	Glutamine amidotransferase of anthranilate synthase
HC658_RS00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_RS00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HC658_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HC658_RS00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HC658_RS00470	COG1396	sequence-specific DNA binding
HC658_RS00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC658_RS00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC658_RS00560	COG4463	regulation of RNA biosynthetic process
HC658_RS00565	COG3880	PFAM UvrB UvrC protein
HC658_RS00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HC658_RS00575	COG0542	response to heat
HC658_RS00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HC658_RS00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HC658_RS00590	COG4956	integral membrane protein (PIN domain superfamily)
HC658_RS00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HC658_RS00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HC658_RS00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC658_RS00610	COG1045	serine acetyltransferase
HC658_RS00615	COG0215	cysteine-tRNA ligase activity
HC658_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC658_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC658_RS00630	COG3688	RNA-binding protein containing a PIN domain
HC658_RS00635	COG1595	DNA-templated transcription, initiation
HC658_RS00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC658_RS00650	COG0250	Participates in transcription elongation, termination and antitermination
HC658_RS00660	COG0081	regulation of translation
HC658_RS00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC658_RS00675	COG2813	Specifically methylates the guanine in position
HC658_RS00680	COG0085	RNA polymerase activity
HC658_RS00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC658_RS00690	COG1358	cellular component organization or biogenesis
HC658_RS00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC658_RS00700	COG0049	tRNA binding
HC658_RS00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC658_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC658_RS00715	COG0596	Alpha beta hydrolase
HC658_RS00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC658_RS00730	COG0088	Forms part of the polypeptide exit tunnel
HC658_RS00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC658_RS00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC658_RS00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC658_RS00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC658_RS00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC658_RS00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC658_RS00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC658_RS00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC658_RS00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC658_RS00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HC658_RS00820	COG0200	Binds to the 23S rRNA
HC658_RS00825	COG0201	protein transport
HC658_RS00830	COG0563	adenylate kinase activity
HC658_RS00835	COG0024	Methionine aminopeptidase
HC658_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC658_RS00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC658_RS00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC658_RS00865	COG0202	RNA polymerase activity
HC658_RS00870	COG0203	ribosomal protein L17
HC658_RS00875	COG1122	ATPase activity
HC658_RS00880	COG1122	ATPase activity
HC658_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC658_RS00890	COG0101	tRNA pseudouridine synthase activity
HC658_RS00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC658_RS00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC658_RS00905	COG2226	methyltransferase
HC658_RS00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS00920	COG0489	protein tyrosine kinase activity
HC658_RS00930	COG2194	sulfuric ester hydrolase activity
HC658_RS00935	COG0726	polysaccharide deacetylase
HC658_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
HC658_RS01025	COG0385	Bile acid
HC658_RS01030	COG2819	hydrolase of the alpha beta superfamily
HC658_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS01050	COG2207	Transcriptional regulator
HC658_RS01055	COG3876	Protein conserved in bacteria
HC658_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
HC658_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_RS01070	COG1263	PTS System
HC658_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS01075	COG1737	Transcriptional regulator
HC658_RS01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC658_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS01090	COG1683	Conserved Protein
HC658_RS01120	COG1595	DNA-templated transcription, initiation
HC658_RS01125	COG5662	AntiSigma factor
HC658_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC658_RS01135	COG4856	YbbR-like protein
HC658_RS01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC658_RS01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC658_RS01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC658_RS01160	COG2169	Transcriptional regulator
HC658_RS01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC658_RS01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC658_RS01175	COG3002	Belongs to the UPF0753 family
HC658_RS01180	COG0288	reversible hydration of carbon dioxide
HC658_RS01190	COG5609	conserved protein (DUF2294)
HC658_RS01195	COG0640	Transcriptional regulator
HC658_RS01200	COG2814	Major facilitator Superfamily
HC658_RS01215	COG0535	radical SAM domain protein
HC658_RS01220	COG1266	CAAX protease self-immunity
HC658_RS01225	COG1131	(ABC) transporter
HC658_RS01235	COG1413	lyase activity
HC658_RS01240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS01245	COG0596	Alpha beta hydrolase
HC658_RS01250	COG0745	RESPONSE REGULATOR receiver
HC658_RS01255	COG0642	Histidine kinase
HC658_RS01265	COG0515	serine threonine protein kinase
HC658_RS01280	COG1113	amino acid transport
HC658_RS01295	COG2602	Beta-lactamase
HC658_RS01300	COG2124	cytochrome p450
HC658_RS01310	COG0531	amino acid
HC658_RS01315	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_RS01320	COG2271	Major facilitator Superfamily
HC658_RS01330	COG0456	acetyltransferase
HC658_RS01330	COG1846	Transcriptional regulator
HC658_RS01335	COG2271	Major facilitator Superfamily
HC658_RS01350	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS01355	COG0697	spore germination
HC658_RS01360	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS01360	COG2207	Transcriptional regulator
HC658_RS01365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HC658_RS01370	COG3591	Belongs to the peptidase S1B family
HC658_RS01380	COG0596	Alpha beta hydrolase
HC658_RS01385	COG1183	phosphatidylcholine synthase activity
HC658_RS01390	COG0586	Pfam SNARE associated Golgi protein
HC658_RS01395	COG0688	phosphatidylethanolamine metabolic process
HC658_RS01405	COG2312	Erythromycin esterase
HC658_RS01410	COG2207	Transcriptional regulator
HC658_RS01420	COG1301	dicarboxylic acid transport
HC658_RS01425	COG1263	PTS System
HC658_RS01425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS01425	COG2190	(PTS) system
HC658_RS01430	COG0363	glucosamine-6-phosphate deaminase activity
HC658_RS01435	COG2188	Transcriptional regulator
HC658_RS01445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_RS01450	COG0833	amino acid
HC658_RS01455	COG2040	homocysteine
HC658_RS01465	COG1115	amino acid carrier protein
HC658_RS01470	COG2066	Belongs to the glutaminase family
HC658_RS01475	COG4191	Histidine kinase
HC658_RS01480	COG0784	Response regulator, receiver
HC658_RS01485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC658_RS01490	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS01495	COG2271	Major facilitator Superfamily
HC658_RS01500	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_RS01505	COG2186	Transcriptional regulator
HC658_RS01510	COG2721	sulfolactate sulfo-lyase activity
HC658_RS01515	COG3173	Aminoglycoside phosphotransferase
HC658_RS01525	COG0697	spore germination
HC658_RS01530	COG0745	RESPONSE REGULATOR receiver
HC658_RS01535	COG2205	protein histidine kinase activity
HC658_RS01540	COG1131	(ABC) transporter
HC658_RS01560	COG3773	Cell wall hydrolase
HC658_RS01565	COG2304	oxidoreductase activity
HC658_RS01575	COG3540	Alkaline phosphatase
HC658_RS01580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_RS01585	COG0805	protein transport
HC658_RS01590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC658_RS01595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC658_RS01600	COG0477	Major facilitator Superfamily
HC658_RS01605	COG1309	transcriptional regulator
HC658_RS01610	COG0252	asparaginase activity
HC658_RS01615	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC658_RS01620	COG1714	RDD family
HC658_RS01625	COG1405	negative regulation of cell septum assembly
HC658_RS01625	COG3012	SEC-C Motif Domain Protein
HC658_RS01630	COG3290	protein histidine kinase activity
HC658_RS01635	COG3279	Response regulator of the LytR AlgR family
HC658_RS01640	COG4555	ABC transporter
HC658_RS01645	COG1668	transmembrane transport
HC658_RS01650	COG0667	Aldo Keto reductase
HC658_RS01665	COG1595	DNA-templated transcription, initiation
HC658_RS01670	COG1595	DNA-templated transcription, initiation
HC658_RS01675	COG1876	peptidase activity
HC658_RS01680	COG0457	Tetratricopeptide repeat
HC658_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS01690	COG0366	Alpha amylase catalytic
HC658_RS01695	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC658_RS01700	COG1121	(ABC) transporter
HC658_RS01705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_RS01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS01715	COG2310	stress, protein
HC658_RS01720	COG2310	stress, protein
HC658_RS01725	COG2310	stress, protein
HC658_RS01730	COG0861	Integral membrane protein TerC family
HC658_RS01740	COG3853	Toxic anion resistance protein (TelA)
HC658_RS01745	COG0477	Major facilitator Superfamily
HC658_RS01750	COG2814	Major facilitator Superfamily
HC658_RS01755	COG0640	Transcriptional regulator
HC658_RS01760	COG0517	IMP dehydrogenase activity
HC658_RS01760	COG4175	Glycine betaine
HC658_RS01765	COG4176	ABC-type proline glycine betaine transport system permease component
HC658_RS01770	COG2113	Glycine betaine
HC658_RS01775	COG1473	amidohydrolase
HC658_RS01780	COG1288	antiporter activity
HC658_RS01790	COG0366	Alpha amylase catalytic
HC658_RS01795	COG0039	L-malate dehydrogenase activity
HC658_RS01800	COG1620	l-lactate permease
HC658_RS01805	COG2814	Major facilitator Superfamily
HC658_RS01810	COG1846	Transcriptional regulator
HC658_RS01815	COG1280	lysine exporter protein (LysE YggA)
HC658_RS01820	COG3403	YqcI/YcgG family
HC658_RS01825	COG1113	amino acid transport
HC658_RS01830	COG3665	Urea carboxylase-associated protein
HC658_RS01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC658_RS01840	COG1660	Displays ATPase and GTPase activities
HC658_RS01845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC658_RS01850	COG2226	methyltransferase
HC658_RS01855	COG0583	DNA-binding transcription factor activity
HC658_RS01860	COG3458	cephalosporin-C deacetylase activity
HC658_RS01865	COG3541	Predicted nucleotidyltransferase
HC658_RS01870	COG0506	proline dehydrogenase activity
HC658_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS01880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_RS01885	COG2508	Transcriptional regulator
HC658_RS01890	COG3689	TIGRFAM TIGR03943 family protein
HC658_RS01895	COG0701	Predicted permease
HC658_RS01900	COG2267	carboxylic ester hydrolase activity
HC658_RS01905	COG0492	ferredoxin-NADP+ reductase activity
HC658_RS01910	COG1587	Uroporphyrinogen-III synthase
HC658_RS01910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC658_RS01915	COG2146	nitrite reductase [NAD(P)H] activity
HC658_RS01920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_RS01925	COG0243	molybdopterin cofactor binding
HC658_RS01930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_RS01935	COG2223	nitrite transmembrane transporter activity
HC658_RS01940	COG1469	GTP cyclohydrolase I activity
HC658_RS01955	COG0523	cobalamin synthesis protein
HC658_RS01960	COG0765	amino acid transport
HC658_RS01965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS01975	COG1714	RDD family
HC658_RS01985	COG2723	6-phospho-beta-galactosidase activity
HC658_RS01995	COG3209	COG3209 Rhs family protein
HC658_RS02000	COG3290	protein histidine kinase activity
HC658_RS02000	COG0840	transmembrane signaling receptor activity
HC658_RS02005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HC658_RS02010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC658_RS02015	COG1733	regulation of RNA biosynthetic process
HC658_RS02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS02035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HC658_RS02040	COG2814	Major facilitator Superfamily
HC658_RS02050	COG0697	spore germination
HC658_RS02065	COG2364	Membrane
HC658_RS02070	COG1126	abc transporter atp-binding protein
HC658_RS02075	COG0765	amino acid transport
HC658_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS02085	COG0583	DNA-binding transcription factor activity
HC658_RS02090	COG0163	prenyltransferase activity
HC658_RS02095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC658_RS02110	COG0596	Alpha beta hydrolase
HC658_RS02115	COG3104	oligopeptide transport
HC658_RS02120	COG5434	Belongs to the glycosyl hydrolase 28 family
HC658_RS02130	COG0697	spore germination
HC658_RS02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC658_RS02145	COG1136	(ABC) transporter
HC658_RS02150	COG0577	efflux transmembrane transporter activity
HC658_RS02155	COG0745	RESPONSE REGULATOR receiver
HC658_RS02160	COG5002	protein histidine kinase activity
HC658_RS02160	COG3850	Histidine kinase
HC658_RS02165	COG0457	Tetratricopeptide repeat
HC658_RS02185	COG0527	aspartate kinase activity
HC658_RS02190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS02195	COG4605	iron ion homeostasis
HC658_RS02200	COG4604	ABC transporter, ATP-binding protein
HC658_RS02205	COG4607	ABC-type enterochelin transport system periplasmic component
HC658_RS02210	COG2814	Major facilitator Superfamily
HC658_RS02215	COG1309	transcriptional regulator
HC658_RS02220	COG0778	Nitroreductase
HC658_RS02225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC658_RS02230	COG0640	Transcriptional regulator
HC658_RS02235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS02240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HC658_RS02245	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS02250	COG4975	Glucose uptake
HC658_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS02260	COG4549	nuclear export factor GLE1
HC658_RS02265	COG1276	copper resistance
HC658_RS02265	COG2372	response to copper ion
HC658_RS02270	COG1349	DNA-binding transcription factor activity
HC658_RS02280	COG2213	PTS system mannitol-specific
HC658_RS02285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS02290	COG0246	Mannitol dehydrogenase
HC658_RS02295	COG0473	3-isopropylmalate dehydrogenase activity
HC658_RS02300	COG0681	Belongs to the peptidase S26 family
HC658_RS02305	COG0412	Dienelactone hydrolase
HC658_RS02310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC658_RS02320	COG0561	phosphatase activity
HC658_RS02325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HC658_RS02330	COG1914	H( )-stimulated, divalent metal cation uptake system
HC658_RS02335	COG4336	lyase activity
HC658_RS02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HC658_RS02345	COG1984	allophanate hydrolase subunit 2
HC658_RS02350	COG1414	Transcriptional regulator
HC658_RS02355	COG2755	lipolytic protein G-D-S-L family
HC658_RS02365	COG2329	Antibiotic biosynthesis monooxygenase
HC658_RS02370	COG0768	penicillin binding
HC658_RS02375	COG4989	oxidoreductase activity
HC658_RS02380	COG3711	transcriptional antiterminator
HC658_RS02385	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS02390	COG2226	methyltransferase
HC658_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS02400	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS02405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS02410	COG3871	stress protein (general stress protein 26)
HC658_RS02420	COG2814	Major facilitator Superfamily
HC658_RS02425	COG1522	sequence-specific DNA binding
HC658_RS02430	COG0551	DNA topoisomerase type I activity
HC658_RS02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC658_RS02435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HC658_RS02440	COG3706	GGDEF domain
HC658_RS02445	COG5298	Protein conserved in bacteria
HC658_RS02450	COG1215	transferase activity, transferring glycosyl groups
HC658_RS02460	COG0531	amino acid
HC658_RS02465	COG0494	nUDIX hydrolase
HC658_RS02470	COG0028	Belongs to the TPP enzyme family
HC658_RS02485	COG1914	H( )-stimulated, divalent metal cation uptake system
HC658_RS02490	COG2261	transglycosylase associated protein
HC658_RS02495	COG4876	unkown
HC658_RS02500	COG2217	Heavy metal translocating P-type atpase
HC658_RS02505	COG3729	General stress protein
HC658_RS02510	COG0662	Cupin 2, conserved barrel domain protein
HC658_RS02515	COG2329	Antibiotic biosynthesis monooxygenase
HC658_RS02520	COG3546	catalase activity
HC658_RS02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HC658_RS02530	COG3290	protein histidine kinase activity
HC658_RS02535	COG4565	transcriptional regulatory protein
HC658_RS02540	COG1301	dicarboxylic acid transport
HC658_RS02545	COG0628	permease
HC658_RS02550	COG1131	(ABC) transporter
HC658_RS02555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_RS02565	COG1960	acyl-CoA dehydrogenase activity
HC658_RS02580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS02590	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC658_RS02595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC658_RS02600	COG0513	Belongs to the DEAD box helicase family
HC658_RS02605	COG3402	PFAM membrane-flanked domain
HC658_RS02610	COG3428	Bacterial PH domain
HC658_RS02615	COG0705	Rhomboid family
HC658_RS02620	COG0736	holo-[acyl-carrier-protein] synthase activity
HC658_RS02625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HC658_RS02630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC658_RS02635	COG0864	Transcriptional regulator
HC658_RS02640	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC658_RS02645	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS02650	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS02655	COG2172	sigma factor antagonist activity
HC658_RS02660	COG2208	phosphoserine phosphatase activity
HC658_RS02665	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS02670	COG2172	sigma factor antagonist activity
HC658_RS02675	COG1191	sigma factor activity
HC658_RS02680	COG2208	phosphoserine phosphatase activity
HC658_RS02685	COG2183	response to ionizing radiation
HC658_RS02695	COG3091	SprT-like family
HC658_RS02735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS02750	COG1476	TRANSCRIPTIONal
HC658_RS02760	COG3239	Fatty acid desaturase
HC658_RS02765	COG1278	Cold shock
HC658_RS02770	COG1329	Transcriptional regulator
HC658_RS02775	COG0697	spore germination
HC658_RS02780	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS02780	COG2207	Transcriptional regulator
HC658_RS02785	COG0697	spore germination
HC658_RS02790	COG2207	Transcriptional regulator
HC658_RS02790	COG3708	Transcriptional regulator
HC658_RS02795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS02800	COG0477	Major facilitator Superfamily
HC658_RS02810	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HC658_RS02825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS02830	COG1309	transcriptional regulator
HC658_RS02835	COG0697	spore germination
HC658_RS02840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS02845	COG2030	dehydratase
HC658_RS02850	COG3545	Serine hydrolase
HC658_RS02855	COG1733	regulation of RNA biosynthetic process
HC658_RS02860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS02865	COG2814	Major facilitator Superfamily
HC658_RS02870	COG1309	transcriptional regulator
HC658_RS02875	COG0640	Transcriptional regulator
HC658_RS02880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC658_RS02890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS02895	COG0697	spore germination
HC658_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS02905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC658_RS02910	COG0640	Transcriptional regulator
HC658_RS02915	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC658_RS02930	COG4585	Histidine kinase
HC658_RS02935	COG2197	response regulator
HC658_RS02940	COG2409	Drug exporters of the RND superfamily
HC658_RS02945	COG0596	Alpha beta hydrolase
HC658_RS02950	COG1811	Na channel or pump
HC658_RS02955	COG0789	Transcriptional regulator
HC658_RS02955	COG4978	Transcriptional regulator
HC658_RS02960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_RS02965	COG0778	Nitroreductase
HC658_RS02970	COG0346	lactoylglutathione lyase activity
HC658_RS02975	COG2259	Doxx family
HC658_RS02980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS03000	COG2323	membrane
HC658_RS03005	COG2323	membrane
HC658_RS03010	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_RS03035	COG0456	acetyltransferase
HC658_RS03045	COG1113	amino acid transport
HC658_RS03050	COG2318	DinB family
HC658_RS03055	COG1846	Transcriptional regulator
HC658_RS03060	COG1033	growth of symbiont in host cell
HC658_RS03060	COG2409	Drug exporters of the RND superfamily
HC658_RS03065	COG0778	Nitroreductase
HC658_RS03070	COG1846	Transcriptional regulator
HC658_RS03075	COG2814	Major facilitator Superfamily
HC658_RS03080	COG0730	response to heat
HC658_RS03085	COG1802	Transcriptional regulator
HC658_RS03090	COG3858	chitin binding
HC658_RS03090	COG1388	LysM domain
HC658_RS03095	COG1819	glycosyl
HC658_RS03105	COG1785	Belongs to the alkaline phosphatase family
HC658_RS03110	COG5646	InterPro IPR014922
HC658_RS03120	COG0454	-acetyltransferase
HC658_RS03125	COG1078	dGTPase activity
HC658_RS03130	COG1388	LysM domain
HC658_RS03135	COG2814	Major facilitator Superfamily
HC658_RS03140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_RS03145	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC658_RS03150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_RS03155	COG2723	6-phospho-beta-galactosidase activity
HC658_RS03160	COG2188	Transcriptional regulator
HC658_RS03165	COG1940	carbohydrate kinase activity
HC658_RS03170	COG1482	cell wall glycoprotein biosynthetic process
HC658_RS03175	COG4124	Belongs to the glycosyl hydrolase 26 family
HC658_RS03220	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HC658_RS03225	COG0802	atpase or kinase
HC658_RS03230	COG1214	PFAM Peptidase M22, glycoprotease
HC658_RS03235	COG0456	acetyltransferase
HC658_RS03240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC658_RS03245	COG0488	(ABC) transporter
HC658_RS03250	COG0315	cyclic pyranopterin monophosphate synthase activity
HC658_RS03255	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC658_RS03260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_RS03265	COG0805	protein transport
HC658_RS03275	COG1266	CAAX protease self-immunity
HC658_RS03285	COG0459	protein refolding
HC658_RS03295	COG3378	Phage plasmid primase P4 family
HC658_RS03310	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC658_RS03315	COG0270	DNA (cytosine-5-)-methyltransferase activity
HC658_RS03330	COG1401	restriction endodeoxyribonuclease activity
HC658_RS03350	COG0457	Tetratricopeptide repeat
HC658_RS03355	COG1063	alcohol dehydrogenase
HC658_RS03360	COG2211	Major facilitator Superfamily
HC658_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_RS03370	COG1842	Phage shock protein A
HC658_RS03375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC658_RS03380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HC658_RS03385	COG4260	virion core protein, lumpy skin disease virus
HC658_RS03395	COG2814	Major facilitator Superfamily
HC658_RS03400	COG1063	alcohol dehydrogenase
HC658_RS03405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HC658_RS03410	COG0823	Involved in the tonB-independent uptake of proteins
HC658_RS03425	COG2267	carboxylic ester hydrolase activity
HC658_RS03435	COG2132	Multicopper oxidase
HC658_RS03440	COG1113	amino acid transport
HC658_RS03450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HC658_RS03455	COG0714	Associated with various cellular activities
HC658_RS03460	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HC658_RS03465	COG1305	Transglutaminase-like
HC658_RS03475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC658_RS03475	COG0519	Catalyzes the synthesis of GMP from XMP
HC658_RS03480	COG2252	PERMEase
HC658_RS03485	COG3064	Membrane
HC658_RS03495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC658_RS03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC658_RS03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC658_RS03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC658_RS03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC658_RS03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC658_RS03530	COG0047	phosphoribosylformylglycinamidine synthase activity
HC658_RS03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC658_RS03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HC658_RS03545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC658_RS03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC658_RS03555	COG0138	bifunctional purine biosynthesis protein purh
HC658_RS03560	COG0151	Belongs to the GarS family
HC658_RS03565	COG1522	sequence-specific DNA binding
HC658_RS03570	COG0531	amino acid
HC658_RS03580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC658_RS03585	COG1470	cell adhesion involved in biofilm formation
HC658_RS03590	COG4496	protein, YerC YecD
HC658_RS03595	COG0069	glutamate synthase activity
HC658_RS03600	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HC658_RS03605	COG0210	DNA helicase
HC658_RS03610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC658_RS03615	COG4851	CamS sex pheromone cAM373 precursor
HC658_RS03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_RS03625	COG1285	pathogenesis
HC658_RS03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_RS03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC658_RS03640	COG0154	amidase activity
HC658_RS03645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC658_RS03650	COG1309	transcriptional regulator
HC658_RS03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HC658_RS03660	COG1597	lipid kinase activity
HC658_RS03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC658_RS03670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_RS03675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_RS03680	COG1002	Type II restriction enzyme, methylase subunits
HC658_RS03685	COG1061	Type III restriction enzyme res subunit
HC658_RS03690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC658_RS03710	COG5444	nuclease activity
HC658_RS03730	COG0457	Tetratricopeptide repeat
HC658_RS03740	COG0217	transcriptional regulatory protein
HC658_RS03750	COG1309	transcriptional regulator
HC658_RS03755	COG3631	Ketosteroid isomerase-related protein
HC658_RS03760	COG0702	epimerase
HC658_RS03775	COG3546	catalase activity
HC658_RS03780	COG0454	-acetyltransferase
HC658_RS03790	COG5578	integral membrane protein
HC658_RS03795	COG2972	Histidine kinase
HC658_RS03800	COG4753	response regulator
HC658_RS03800	COG2207	Transcriptional regulator
HC658_RS03805	COG1653	transport
HC658_RS03810	COG1175	transmembrane transport
HC658_RS03815	COG0395	ABC-type sugar transport system, permease component
HC658_RS03820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC658_RS03825	COG2207	Transcriptional regulator
HC658_RS03830	COG2755	lipolytic protein G-D-S-L family
HC658_RS03840	COG5578	integral membrane protein
HC658_RS03845	COG3401	FG-GAP repeat protein
HC658_RS03850	COG3401	FG-GAP repeat protein
HC658_RS03855	COG2755	lipolytic protein G-D-S-L family
HC658_RS03860	COG1874	Beta-galactosidase
HC658_RS03870	COG1653	transport
HC658_RS03875	COG4209	transmembrane transport
HC658_RS03880	COG0395	ABC-type sugar transport system, permease component
HC658_RS03885	COG1486	melibiose metabolic process
HC658_RS03890	COG2323	membrane
HC658_RS03895	COG2329	Antibiotic biosynthesis monooxygenase
HC658_RS03900	COG0346	lactoylglutathione lyase activity
HC658_RS03915	COG5583	Uncharacterized small protein (DUF2292)
HC658_RS03920	COG0670	Belongs to the BI1 family
HC658_RS03925	COG0697	spore germination
HC658_RS03930	COG1846	Transcriptional regulator
HC658_RS03935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC658_RS03945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_RS03945	COG2124	cytochrome p450
HC658_RS03950	COG1368	sulfuric ester hydrolase activity
HC658_RS03955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HC658_RS03960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_RS03965	COG1442	glycosyl transferase family 8
HC658_RS03970	COG1216	Glycosyl transferase, family 2
HC658_RS03975	COG1442	glycosyl transferase family 8
HC658_RS03980	COG2223	nitrite transmembrane transporter activity
HC658_RS03985	COG1011	Hydrolase
HC658_RS03990	COG0531	amino acid
HC658_RS03995	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS04000	COG0840	transmembrane signaling receptor activity
HC658_RS04005	COG0488	(ABC) transporter
HC658_RS04015	COG0789	Transcriptional regulator
HC658_RS04020	COG2814	Major facilitator Superfamily
HC658_RS04030	COG0488	(ABC) transporter
HC658_RS04035	COG0513	Belongs to the DEAD box helicase family
HC658_RS04040	COG0456	acetyltransferase
HC658_RS04045	COG2130	NADP-dependent
HC658_RS04050	COG2211	Major facilitator Superfamily
HC658_RS04055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HC658_RS04060	COG1120	ATPase activity
HC658_RS04065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS04075	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC658_RS04090	COG3866	Pectate lyase
HC658_RS04095	COG0471	metal ion transport
HC658_RS04100	COG3290	protein histidine kinase activity
HC658_RS04105	COG4565	transcriptional regulatory protein
HC658_RS04110	COG3181	Tripartite tricarboxylate transporter family receptor
HC658_RS04115	COG2851	Citrate transporter
HC658_RS04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS04125	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HC658_RS04130	COG1254	Belongs to the acylphosphatase family
HC658_RS04135	COG2258	MOSC domain
HC658_RS04155	COG0024	Methionine aminopeptidase
HC658_RS04160	COG1263	PTS System
HC658_RS04160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS04165	COG1368	sulfuric ester hydrolase activity
HC658_RS04180	COG1115	amino acid carrier protein
HC658_RS04185	COG0531	amino acid
HC658_RS04205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS04205	COG1263	PTS System
HC658_RS04210	COG0366	Alpha amylase catalytic
HC658_RS04215	COG2188	Transcriptional regulator
HC658_RS04220	COG0778	Nitroreductase
HC658_RS04225	COG0737	Belongs to the 5'-nucleotidase family
HC658_RS04230	COG0693	protein deglycase activity
HC658_RS04235	COG2814	Major facilitator Superfamily
HC658_RS04240	COG4840	Belongs to the UPF0435 family
HC658_RS04245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_RS04250	COG4980	gas vesicle protein
HC658_RS04255	COG1295	ribonuclease BN
HC658_RS04260	COG0477	Major facilitator Superfamily
HC658_RS04265	COG0387	Pfam Sodium calcium exchanger
HC658_RS04275	COG0668	transmembrane transport
HC658_RS04280	COG0535	radical SAM domain protein
HC658_RS04290	COG0726	polysaccharide deacetylase
HC658_RS04295	COG2084	Dehydrogenase
HC658_RS04300	COG0598	Magnesium transport protein CorA
HC658_RS04305	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HC658_RS04310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC658_RS04320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC658_RS04325	COG4637	Psort location Cytoplasmic, score
HC658_RS04335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_RS04340	COG0022	dehydrogenase e1 component
HC658_RS04345	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_RS04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_RS04355	COG3284	Transcriptional regulator
HC658_RS04365	COG1742	UPF0060 membrane protein
HC658_RS04390	COG4842	Belongs to the WXG100 family
HC658_RS04395	COG1486	melibiose metabolic process
HC658_RS04400	COG1737	Transcriptional regulator
HC658_RS04405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS04405	COG1263	PTS System
HC658_RS04410	COG1132	(ABC) transporter
HC658_RS04415	COG1132	(ABC) transporter
HC658_RS04420	COG2259	Doxx family
HC658_RS04425	COG2514	catechol 2,3-dioxygenase activity
HC658_RS04430	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS04430	COG4977	sequence-specific DNA binding
HC658_RS04435	COG2814	Major facilitator Superfamily
HC658_RS04440	COG1082	Xylose isomerase domain protein TIM barrel
HC658_RS04445	COG0673	inositol 2-dehydrogenase activity
HC658_RS04450	COG4585	Histidine kinase
HC658_RS04455	COG2197	response regulator
HC658_RS04460	COG1131	(ABC) transporter
HC658_RS04465	COG1511	domain protein
HC658_RS04465	COG0842	Transport permease protein
HC658_RS04470	COG0842	Transport permease protein
HC658_RS04475	COG1695	Transcriptional regulator
HC658_RS04480	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HC658_RS04485	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HC658_RS04490	COG1309	transcriptional regulator
HC658_RS04495	COG2814	Major facilitator Superfamily
HC658_RS04500	COG2318	DinB family
HC658_RS04505	COG2814	Major facilitator Superfamily
HC658_RS04510	COG1846	Transcriptional regulator
HC658_RS04515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC658_RS04515	COG0392	lysyltransferase activity
HC658_RS04520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS04525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS04530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS04535	COG0384	phenazine biosynthesis protein PhzF
HC658_RS04540	COG0778	Nitroreductase
HC658_RS04555	COG1090	epimerase
HC658_RS04560	COG2137	regulation of response to DNA damage stimulus
HC658_RS04570	COG2814	Major facilitator Superfamily
HC658_RS04585	COG3103	Sh3 type 3 domain protein
HC658_RS04590	COG5658	integral membrane protein
HC658_RS04595	COG0596	Alpha beta hydrolase
HC658_RS04600	COG0463	Glycosyl transferase, family 2
HC658_RS04605	COG4485	Bacterial membrane protein, YfhO
HC658_RS04610	COG1988	membrane-bound metal-dependent
HC658_RS04615	COG1194	a g-specific adenine glycosylase
HC658_RS04625	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS04640	COG3557	Belongs to the UPF0374 family
HC658_RS04645	COG1132	(ABC) transporter
HC658_RS04650	COG4129	membrane
HC658_RS04655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC658_RS04660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HC658_RS04665	COG0735	belongs to the Fur family
HC658_RS04775	COG4326	sporulation control protein
HC658_RS04785	COG5577	PFAM Coat F domain
HC658_RS04790	COG3340	Belongs to the peptidase S51 family
HC658_RS04795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HC658_RS04800	COG0277	FAD linked oxidase domain protein
HC658_RS04810	COG0753	catalase activity
HC658_RS04815	COG1116	anion transmembrane transporter activity
HC658_RS04820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC658_RS04825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC658_RS04830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS04840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC658_RS04850	COG1476	TRANSCRIPTIONal
HC658_RS04860	COG3382	B3 4 domain protein
HC658_RS04865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC658_RS04875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC658_RS04880	COG0789	Transcriptional regulator
HC658_RS04885	COG1664	Polymer-forming cytoskeletal
HC658_RS04890	COG1664	Polymer-forming cytoskeletal
HC658_RS04895	COG2766	serine protein kinase
HC658_RS04900	COG2718	Belongs to the UPF0229 family
HC658_RS04905	COG1846	Transcriptional regulator
HC658_RS04910	COG1566	PFAM secretion protein HlyD family protein
HC658_RS04915	COG2814	Major facilitator Superfamily
HC658_RS04920	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC658_RS04940	COG1725	Transcriptional regulator
HC658_RS04945	COG1131	(ABC) transporter
HC658_RS04950	COG1131	(ABC) transporter
HC658_RS04955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_RS04960	COG1278	Cold shock
HC658_RS04965	COG1464	Belongs to the NlpA lipoprotein family
HC658_RS04970	COG3706	GGDEF domain
HC658_RS04975	COG1823	symporter activity
HC658_RS04995	COG5577	PFAM Coat F domain
HC658_RS05000	COG1525	nuclease
HC658_RS05000	COG0737	Belongs to the 5'-nucleotidase family
HC658_RS05000	COG4085	toxin activity
HC658_RS05005	COG3764	Sortase (surface protein transpeptidase)
HC658_RS05010	COG0564	pseudouridine synthase activity
HC658_RS05020	COG0517	IMP dehydrogenase activity
HC658_RS05025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC658_RS05030	COG3153	acetyltransferase
HC658_RS05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC658_RS05035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_RS05040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HC658_RS05045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC658_RS05050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC658_RS05055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC658_RS05060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC658_RS05065	COG2203	Gaf domain
HC658_RS05065	COG4585	Histidine kinase
HC658_RS05070	COG2197	response regulator
HC658_RS05075	COG0431	NADPH-dependent FMN reductase
HC658_RS05090	COG0791	NLP P60 protein
HC658_RS05090	COG1388	LysM domain
HC658_RS05095	COG1959	2 iron, 2 sulfur cluster binding
HC658_RS05100	COG0668	transmembrane transport
HC658_RS05105	COG2719	SpoVR family
HC658_RS05110	COG1785	Belongs to the alkaline phosphatase family
HC658_RS05115	COG1388	LysM domain
HC658_RS05115	COG0791	NLP P60 protein
HC658_RS05120	COG0583	DNA-binding transcription factor activity
HC658_RS05125	COG0372	Belongs to the citrate synthase family
HC658_RS05130	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS05135	COG0531	amino acid
HC658_RS05140	COG0733	neurotransmitter:sodium symporter activity
HC658_RS05145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS05150	COG0456	acetyltransferase
HC658_RS05165	COG1595	DNA-templated transcription, initiation
HC658_RS05170	COG0667	Aldo Keto reductase
HC658_RS05175	COG0204	Acyl-transferase
HC658_RS05180	COG1253	flavin adenine dinucleotide binding
HC658_RS05185	COG0789	Transcriptional regulator
HC658_RS05190	COG0436	Aminotransferase
HC658_RS05195	COG1253	flavin adenine dinucleotide binding
HC658_RS05200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC658_RS05205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HC658_RS05210	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_RS05220	COG0668	transmembrane transport
HC658_RS05225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC658_RS05230	COG0726	polysaccharide deacetylase
HC658_RS05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_RS05240	COG1757	Na H antiporter
HC658_RS05245	COG0589	response to stress
HC658_RS05255	COG1132	(ABC) transporter
HC658_RS05260	COG1132	(ABC) transporter
HC658_RS05265	COG0702	epimerase
HC658_RS05285	COG0189	ligase activity
HC658_RS05290	COG0189	ligase activity
HC658_RS05295	COG4399	Belongs to the UPF0754 family
HC658_RS05300	COG3679	Belongs to the UPF0342 family
HC658_RS05305	COG4335	DNA alkylation repair
HC658_RS05310	COG0561	phosphatase activity
HC658_RS05315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC658_RS05320	COG0475	glutathione-regulated potassium exporter activity
HC658_RS05325	COG0490	domain, Protein
HC658_RS05335	COG1024	Enoyl-CoA hydratase
HC658_RS05345	COG4152	abc transporter atp-binding protein
HC658_RS05350	COG1668	transmembrane transport
HC658_RS05355	COG0420	3'-5' exonuclease activity
HC658_RS05360	COG4717	serine-type aminopeptidase activity
HC658_RS05365	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC658_RS05375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC658_RS05405	COG1846	Transcriptional regulator
HC658_RS05410	COG4980	gas vesicle protein
HC658_RS05425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HC658_RS05430	COG0537	adenosine 5'-monophosphoramidase activity
HC658_RS05435	COG1131	(ABC) transporter
HC658_RS05440	COG4473	ABC transporter
HC658_RS05450	COG1473	amidohydrolase
HC658_RS05455	COG3069	C4-dicarboxylate transmembrane transporter activity
HC658_RS05465	COG2329	Antibiotic biosynthesis monooxygenase
HC658_RS05470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_RS05475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HC658_RS05490	COG1309	transcriptional regulator
HC658_RS05495	COG1511	domain protein
HC658_RS05500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_RS05505	COG4377	Putative membrane peptidase family (DUF2324)
HC658_RS05515	COG1363	Peptidase, m42
HC658_RS05520	COG4405	Protein conserved in bacteria
HC658_RS05525	COG1301	dicarboxylic acid transport
HC658_RS05535	COG1234	tRNA 3'-trailer cleavage
HC658_RS05540	COG0095	Lipoate-protein ligase
HC658_RS05545	COG0702	epimerase
HC658_RS05550	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS05560	COG0501	Belongs to the peptidase M48B family
HC658_RS05570	COG0456	acetyltransferase
HC658_RS05575	COG0604	alcohol dehydrogenase
HC658_RS05580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HC658_RS05585	COG0406	alpha-ribazole phosphatase activity
HC658_RS05590	COG0183	Belongs to the thiolase family
HC658_RS05595	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS05600	COG1268	BioY protein
HC658_RS05605	COG0840	transmembrane signaling receptor activity
HC658_RS05610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_RS05610	COG0723	plastoquinol--plastocyanin reductase activity
HC658_RS05615	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS05625	COG4903	ComK protein
HC658_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS05640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_RS05655	COG0398	Pfam SNARE associated Golgi protein
HC658_RS05660	COG0681	Belongs to the peptidase S26 family
HC658_RS05665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HC658_RS05670	COG1846	Transcriptional regulator
HC658_RS05675	COG0738	Major facilitator superfamily
HC658_RS05680	COG0673	inositol 2-dehydrogenase activity
HC658_RS05685	COG0561	phosphatase activity
HC658_RS05690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_RS05695	COG1609	Transcriptional regulator
HC658_RS05700	COG3180	Ammonia monooxygenase
HC658_RS05705	COG0477	Major facilitator Superfamily
HC658_RS05705	COG2814	Major facilitator Superfamily
HC658_RS05710	COG4533	DNA binding
HC658_RS05720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HC658_RS05725	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC658_RS05730	COG1074	ATP-dependent DNA helicase activity
HC658_RS05735	COG0420	3'-5' exonuclease activity
HC658_RS05740	COG0419	ATPase involved in DNA repair
HC658_RS05745	COG1403	HNH endonuclease
HC658_RS05785	COG5337	Spore coat protein CotH
HC658_RS05790	COG0179	Fumarylacetoacetate (FAA) hydrolase
HC658_RS05800	COG1404	Belongs to the peptidase S8 family
HC658_RS05810	COG0367	asparagine synthase
HC658_RS05815	COG2318	DinB family
HC658_RS05820	COG1562	ergosterol biosynthetic process
HC658_RS05825	COG0534	Mate efflux family protein
HC658_RS05830	COG2207	Transcriptional regulator
HC658_RS05830	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS05835	COG1609	Transcriptional regulator
HC658_RS05840	COG0673	inositol 2-dehydrogenase activity
HC658_RS05845	COG2318	DinB family
HC658_RS05850	COG1279	arginine transmembrane transporter activity
HC658_RS05855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC658_RS05860	COG1357	PFAM Pentapeptide repeats (8 copies)
HC658_RS05865	COG2267	carboxylic ester hydrolase activity
HC658_RS05870	COG0529	Catalyzes the synthesis of activated sulfate
HC658_RS05875	COG2046	Belongs to the sulfate adenylyltransferase family
HC658_RS05880	COG0175	sulfate reduction
HC658_RS05885	COG2045	Belongs to the ComB family
HC658_RS05890	COG1809	phosphosulfolactate synthase activity
HC658_RS05895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS05900	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_RS05905	COG2814	Major facilitator Superfamily
HC658_RS05910	COG0454	-acetyltransferase
HC658_RS05915	COG2153	protein acetylation
HC658_RS05920	COG0646	methionine synthase
HC658_RS05920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HC658_RS05925	COG1666	GTP binding
HC658_RS05930	COG2996	Protein conserved in bacteria
HC658_RS05950	COG1695	Transcriptional regulator
HC658_RS05965	COG3227	Zinc metalloprotease (Elastase)
HC658_RS05970	COG1307	EDD domain protein, DegV family
HC658_RS05975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS05995	COG0561	phosphatase activity
HC658_RS06000	COG1073	alpha beta
HC658_RS06005	COG2151	metal-sulfur cluster biosynthetic enzyme
HC658_RS06015	COG0277	FAD linked oxidase domain protein
HC658_RS06020	COG2271	Major facilitator Superfamily
HC658_RS06025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HC658_RS06030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HC658_RS06040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC658_RS06045	COG0505	Belongs to the CarA family
HC658_RS06050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC658_RS06055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HC658_RS06070	COG2267	carboxylic ester hydrolase activity
HC658_RS06080	COG1744	ABC transporter substrate-binding protein PnrA-like
HC658_RS06095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_RS06100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC658_RS06105	COG5504	Zn-dependent protease
HC658_RS06110	COG0444	Belongs to the ABC transporter superfamily
HC658_RS06115	COG4608	Belongs to the ABC transporter superfamily
HC658_RS06125	COG0601	transmembrane transport
HC658_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_RS06140	COG0180	Tryptophanyl-tRNA synthetase
HC658_RS06145	COG4166	transmembrane transport
HC658_RS06150	COG0601	transmembrane transport
HC658_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_RS06160	COG0444	Belongs to the ABC transporter superfamily
HC658_RS06165	COG4608	Belongs to the ABC transporter superfamily
HC658_RS06170	COG2814	Major facilitator Superfamily
HC658_RS06175	COG0456	acetyltransferase
HC658_RS06180	COG1393	Belongs to the ArsC family
HC658_RS06185	COG0861	Integral membrane protein TerC family
HC658_RS06195	COG4862	establishment of competence for transformation
HC658_RS06205	COG4469	Competence protein
HC658_RS06210	COG1164	Oligoendopeptidase f
HC658_RS06225	COG2346	COG2346, Truncated hemoglobins
HC658_RS06230	COG0741	lytic transglycosylase activity
HC658_RS06235	COG4116	CYTH
HC658_RS06245	COG2357	RelA SpoT domain protein
HC658_RS06250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC658_RS06255	COG0564	pseudouridine synthase activity
HC658_RS06260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HC658_RS06265	COG0475	glutathione-regulated potassium exporter activity
HC658_RS06265	COG0569	domain protein
HC658_RS06270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HC658_RS06275	COG0352	thiamine-phosphate diphosphorylase activity
HC658_RS06280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_RS06285	COG2104	thiamine diphosphate biosynthetic process
HC658_RS06290	COG2022	thiamine diphosphate biosynthetic process
HC658_RS06295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC658_RS06300	COG0351	phosphomethylpyrimidine kinase
HC658_RS06305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC658_RS06360	COG0210	DNA helicase
HC658_RS06370	COG2153	protein acetylation
HC658_RS06375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC658_RS06380	COG2382	esterase
HC658_RS06385	COG0626	cystathionine gamma-synthase activity
HC658_RS06390	COG0626	cystathionine gamma-synthase activity
HC658_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS06400	COG5505	Protein of unknown function (DUF819)
HC658_RS06420	COG5444	nuclease activity
HC658_RS06470	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HC658_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS06485	COG3711	transcriptional antiterminator
HC658_RS06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS06490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_RS06490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_RS06495	COG1482	cell wall glycoprotein biosynthetic process
HC658_RS06505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS06515	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC658_RS06530	COG0109	protoheme IX farnesyltransferase activity
HC658_RS06540	COG0726	polysaccharide deacetylase
HC658_RS06555	COG5504	Zn-dependent protease
HC658_RS06560	COG2205	protein histidine kinase activity
HC658_RS06570	COG3383	formate dehydrogenase (NAD+) activity
HC658_RS06575	COG2427	Protein of unknown function (DUF1641)
HC658_RS06585	COG1051	belongs to the nudix hydrolase family
HC658_RS06595	COG2124	cytochrome p450
HC658_RS06600	COG1819	glycosyl
HC658_RS06610	COG1587	Uroporphyrinogen-III synthase
HC658_RS06615	COG0390	transport system, permease component
HC658_RS06620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_RS06625	COG0697	spore germination
HC658_RS06630	COG4297	protein containing double-stranded beta helix domain
HC658_RS06640	COG1252	NADH dehydrogenase
HC658_RS06645	COG1904	glucuronate isomerase
HC658_RS06650	COG2211	Major facilitator Superfamily
HC658_RS06655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HC658_RS06660	COG1063	alcohol dehydrogenase
HC658_RS06665	COG1312	Catalyzes the dehydration of D-mannonate
HC658_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS06675	COG2271	Major facilitator Superfamily
HC658_RS06680	COG1609	Transcriptional regulator
HC658_RS06685	COG0246	Mannitol dehydrogenase
HC658_RS06690	COG2721	sulfolactate sulfo-lyase activity
HC658_RS06695	COG0730	response to heat
HC658_RS06700	COG2318	DinB family
HC658_RS06705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HC658_RS06710	COG0457	Tetratricopeptide repeat
HC658_RS06720	COG2350	Protein conserved in bacteria
HC658_RS06725	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_RS06725	COG1388	LysM domain
HC658_RS06725	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS06735	COG4195	phage-related replication protein
HC658_RS06740	COG3546	catalase activity
HC658_RS06745	COG2856	Zn peptidase
HC658_RS06750	COG1396	sequence-specific DNA binding
HC658_RS06760	COG1522	sequence-specific DNA binding
HC658_RS06765	COG1484	DNA-dependent DNA replication
HC658_RS06785	COG1595	DNA-templated transcription, initiation
HC658_RS06790	COG3728	DNA packaging
HC658_RS06790	COG5484	DNA packaging
HC658_RS06795	COG1783	phage Terminase large subunit
HC658_RS06800	COG5518	Phage portal protein
HC658_RS06805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC658_RS06810	COG4653	Phage capsid family
HC658_RS06860	COG3953	SLT domain
HC658_RS06860	COG5412	phage tail tape measure protein
HC658_RS06865	COG1652	LysM domain
HC658_RS06870	COG4193	domain, Protein
HC658_RS06880	COG3628	GPW Gp25 family protein
HC658_RS06885	COG3299	homolog of phage Mu protein gp47
HC658_RS06890	COG3778	Protein conserved in bacteria
HC658_RS06930	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_RS06930	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS06950	COG0306	phosphate transporter
HC658_RS06955	COG1392	Phosphate transport regulator
HC658_RS06960	COG0531	amino acid
HC658_RS06965	COG0346	lactoylglutathione lyase activity
HC658_RS06970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC658_RS06975	COG0463	Glycosyl transferase, family 2
HC658_RS06985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_RS06990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_RS06995	COG2362	D-Aminopeptidase
HC658_RS07000	COG0601	transmembrane transport
HC658_RS07005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC658_RS07010	COG0444	Belongs to the ABC transporter superfamily
HC658_RS07015	COG4166	transmembrane transport
HC658_RS07020	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC658_RS07025	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_RS07030	COG0791	NLP P60 protein
HC658_RS07035	COG4608	Belongs to the ABC transporter superfamily
HC658_RS07040	COG2706	6-phosphogluconolactonase activity
HC658_RS07045	COG1834	amidinotransferase
HC658_RS07050	COG1607	acyl-coa hydrolase
HC658_RS07055	COG1017	nitric oxide dioxygenase activity
HC658_RS07055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HC658_RS07065	COG2323	membrane
HC658_RS07070	COG2318	DinB family
HC658_RS07075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS07080	COG2076	Multidrug Resistance protein
HC658_RS07085	COG2076	Multidrug Resistance protein
HC658_RS07090	COG0788	formyltetrahydrofolate deformylase activity
HC658_RS07095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC658_RS07100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC658_RS07105	COG1764	response to oxidative stress
HC658_RS07110	COG1846	Transcriptional regulator
HC658_RS07115	COG1764	response to oxidative stress
HC658_RS07125	COG0590	tRNA wobble adenosine to inosine editing
HC658_RS07130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_RS07135	COG1404	Belongs to the peptidase S8 family
HC658_RS07140	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS07145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HC658_RS07150	COG1122	ATPase activity
HC658_RS07155	COG4721	ABC-type cobalt transport system, permease component
HC658_RS07165	COG0745	RESPONSE REGULATOR receiver
HC658_RS07170	COG5002	protein histidine kinase activity
HC658_RS07170	COG3850	Histidine kinase
HC658_RS07175	COG3212	peptidase
HC658_RS07180	COG3212	peptidase
HC658_RS07190	COG2239	Acts as a magnesium transporter
HC658_RS07195	COG0789	Transcriptional regulator
HC658_RS07210	COG1846	Transcriptional regulator
HC658_RS07215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_RS07220	COG0726	polysaccharide deacetylase
HC658_RS07225	COG1408	metallophosphoesterase
HC658_RS07235	COG0463	Glycosyl transferase, family 2
HC658_RS07240	COG3285	dna ligase
HC658_RS07240	COG1793	dna ligase
HC658_RS07245	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HC658_RS07250	COG3300	MHYT domain
HC658_RS07250	COG5001	Diguanylate cyclase
HC658_RS07255	COG0586	Pfam SNARE associated Golgi protein
HC658_RS07260	COG0861	Integral membrane protein TerC family
HC658_RS07265	COG1191	sigma factor activity
HC658_RS07285	COG0501	Belongs to the peptidase M48B family
HC658_RS07290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC658_RS07305	COG3594	Acyltransferase
HC658_RS07310	COG5002	protein histidine kinase activity
HC658_RS07315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC658_RS07325	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HC658_RS07330	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HC658_RS07335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HC658_RS07340	COG0436	Aminotransferase
HC658_RS07345	COG1850	ribulose-bisphosphate carboxylase activity
HC658_RS07350	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HC658_RS07355	COG0235	Class ii aldolase
HC658_RS07360	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HC658_RS07365	COG3339	Conserved Protein
HC658_RS07380	COG3852	Histidine kinase
HC658_RS07385	COG1846	Transcriptional regulator
HC658_RS07390	COG1360	Flagellar Motor Protein
HC658_RS07395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC658_RS07400	COG0542	response to heat
HC658_RS07405	COG3949	Membrane
HC658_RS07410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HC658_RS07415	COG0720	synthase
HC658_RS07420	COG0602	queuosine metabolic process
HC658_RS07425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HC658_RS07430	COG1733	regulation of RNA biosynthetic process
HC658_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS07440	COG4641	Protein conserved in bacteria
HC658_RS07440	COG1388	LysM domain
HC658_RS07445	COG1388	LysM domain
HC658_RS07450	COG3858	chitin binding
HC658_RS07460	COG4873	Protein conserved in bacteria
HC658_RS07470	COG3773	Cell wall hydrolase
HC658_RS07475	COG2244	polysaccharide biosynthetic process
HC658_RS07480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS07485	COG2217	Heavy metal translocating P-type atpase
HC658_RS07495	COG0006	proline dipeptidase activity
HC658_RS07500	COG1609	Transcriptional regulator
HC658_RS07505	COG3711	transcriptional antiterminator
HC658_RS07510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS07510	COG2190	(PTS) system
HC658_RS07510	COG1263	PTS System
HC658_RS07515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS07520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC658_RS07530	COG1533	DNA photolyase activity
HC658_RS07535	COG0456	acetyltransferase
HC658_RS07540	COG0840	transmembrane signaling receptor activity
HC658_RS07545	COG2084	Dehydrogenase
HC658_RS07550	COG2340	Cysteine-rich secretory protein family
HC658_RS07555	COG0768	penicillin binding
HC658_RS07560	COG4191	Histidine kinase
HC658_RS07565	COG0436	Aminotransferase
HC658_RS07575	COG0835	chemotaxis
HC658_RS07575	COG0784	Response regulator, receiver
HC658_RS07585	COG2814	Major facilitator Superfamily
HC658_RS07590	COG1376	ErfK ybiS ycfS ynhG family protein
HC658_RS07595	COG1408	metallophosphoesterase
HC658_RS07600	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS07605	COG2200	EAL domain
HC658_RS07610	COG4703	Protein of unknown function (DUF1797)
HC658_RS07615	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HC658_RS07625	COG0517	IMP dehydrogenase activity
HC658_RS07630	COG0583	DNA-binding transcription factor activity
HC658_RS07635	COG0716	FMN binding
HC658_RS07645	COG0716	FMN binding
HC658_RS07650	COG2171	N-acyltransferase activity
HC658_RS07655	COG1473	amidohydrolase
HC658_RS07665	COG0668	transmembrane transport
HC658_RS07670	COG0450	alkyl hydroperoxide reductase
HC658_RS07675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS07690	COG0746	molybdenum cofactor guanylyltransferase activity
HC658_RS07695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HC658_RS07700	COG0303	'Molybdopterin
HC658_RS07705	COG1763	Mo-molybdopterin cofactor biosynthetic process
HC658_RS07710	COG0314	molybdopterin synthase activity
HC658_RS07715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HC658_RS07720	COG1132	(ABC) transporter
HC658_RS07725	COG1132	(ABC) transporter
HC658_RS07735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC658_RS07740	COG1136	(ABC) transporter
HC658_RS07745	COG0577	efflux transmembrane transporter activity
HC658_RS07750	COG1349	DNA-binding transcription factor activity
HC658_RS07755	COG1105	Belongs to the carbohydrate kinase PfkB family
HC658_RS07760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_RS07760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC658_RS07760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS07765	COG0681	Belongs to the peptidase S26 family
HC658_RS07775	COG0488	(ABC) transporter
HC658_RS07780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC658_RS07785	COG2309	aminopeptidase activity
HC658_RS07795	COG1077	Cell shape determining protein MreB Mrl
HC658_RS07800	COG2002	toxin-antitoxin pair type II binding
HC658_RS07805	COG3852	Histidine kinase
HC658_RS07810	COG2105	PFAM AIG2 family protein
HC658_RS07810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HC658_RS07815	COG0569	domain protein
HC658_RS07820	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HC658_RS07825	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC658_RS07835	COG0561	phosphatase activity
HC658_RS07840	COG0242	peptide deformylase activity
HC658_RS07850	COG0497	DNA recombination
HC658_RS07855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_RS07860	COG0022	dehydrogenase e1 component
HC658_RS07865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_RS07870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_RS07875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS07885	COG1982	Orn Lys Arg decarboxylase major
HC658_RS07890	COG4476	Belongs to the UPF0223 family
HC658_RS07895	COG4493	Belongs to the UPF0637 family
HC658_RS07905	COG0483	inositol monophosphate 1-phosphatase activity
HC658_RS07915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HC658_RS07965	COG4896	Protein conserved in bacteria
HC658_RS07975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HC658_RS07980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC658_RS07985	COG2066	Belongs to the glutaminase family
HC658_RS07990	COG4838	Belongs to the UPF0358 family
HC658_RS07995	COG0772	Belongs to the SEDS family
HC658_RS08000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC658_RS08005	COG1612	heme a metabolic process
HC658_RS08010	COG0109	protoheme IX farnesyltransferase activity
HC658_RS08015	COG2010	Cytochrome c
HC658_RS08015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC658_RS08020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC658_RS08025	COG1845	cytochrome c oxidase, subunit III
HC658_RS08030	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC658_RS08035	COG3336	cytochrome c oxidase
HC658_RS08045	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HC658_RS08050	COG2340	Cysteine-rich secretory protein family
HC658_RS08065	COG3679	Belongs to the UPF0342 family
HC658_RS08070	COG4471	UPF0298 protein
HC658_RS08075	COG0742	ribosomal rna small subunit methyltransferase
HC658_RS08080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC658_RS08085	COG3314	Sporulation integral membrane protein YlbJ
HC658_RS08090	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC658_RS08095	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC658_RS08100	COG1323	Belongs to the UPF0348 family
HC658_RS08110	COG1399	metal-binding, possibly nucleic acid-binding protein
HC658_RS08125	COG0454	-acetyltransferase
HC658_RS08130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC658_RS08135	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HC658_RS08140	COG2001	Belongs to the MraZ family
HC658_RS08145	COG0275	rRNA processing
HC658_RS08150	COG4839	cell division protein FtsL
HC658_RS08160	COG0768	penicillin binding
HC658_RS08165	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC658_RS08170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC658_RS08175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC658_RS08180	COG0772	Belongs to the SEDS family
HC658_RS08185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_RS08190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC658_RS08195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HC658_RS08200	COG3879	Bacterial protein of unknown function (DUF881)
HC658_RS08205	COG3879	Bacterial protein of unknown function (DUF881)
HC658_RS08210	COG3856	small basic protein
HC658_RS08215	COG0849	cell division
HC658_RS08220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HC658_RS08225	COG1404	Belongs to the peptidase S8 family
HC658_RS08225	COG4412	M6 family metalloprotease domain protein
HC658_RS08235	COG1191	sigma factor activity
HC658_RS08240	COG1191	sigma factor activity
HC658_RS08245	COG1119	ATPase activity
HC658_RS08250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_RS08255	COG1873	PFAM PRC-barrel domain
HC658_RS08265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC658_RS08270	COG1799	cell septum assembly
HC658_RS08275	COG0762	integral membrane protein
HC658_RS08280	COG2302	S4 RNA-binding domain
HC658_RS08285	COG3599	regulation of cell shape
HC658_RS08290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC658_RS08295	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_RS08300	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC658_RS08305	COG0564	pseudouridine synthase activity
HC658_RS08310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HC658_RS08315	COG2233	PERMEase
HC658_RS08320	COG0540	Belongs to the ATCase OTCase family
HC658_RS08325	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC658_RS08330	COG0505	Belongs to the CarA family
HC658_RS08335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC658_RS08340	COG0543	2 iron, 2 sulfur cluster binding
HC658_RS08345	COG0167	dihydroorotate dehydrogenase activity
HC658_RS08350	COG0284	orotidine-5'-phosphate decarboxylase activity
HC658_RS08355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HC658_RS08360	COG0175	sulfate reduction
HC658_RS08365	COG0306	phosphate transporter
HC658_RS08370	COG2046	Belongs to the sulfate adenylyltransferase family
HC658_RS08375	COG0529	Catalyzes the synthesis of activated sulfate
HC658_RS08380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HC658_RS08385	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HC658_RS08390	COG1648	precorrin-2 dehydrogenase activity
HC658_RS08395	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC658_RS08400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC658_RS08405	COG1561	YicC-like family, N-terminal region
HC658_RS08415	COG0194	GDP metabolic process
HC658_RS08420	COG1758	RNA polymerase activity
HC658_RS08425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC658_RS08430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC658_RS08435	COG0242	peptide deformylase activity
HC658_RS08440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC658_RS08445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC658_RS08445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC658_RS08450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC658_RS08455	COG0631	protein serine/threonine phosphatase activity
HC658_RS08460	COG0515	serine threonine protein kinase
HC658_RS08460	COG2815	serine threonine protein kinase
HC658_RS08465	COG1162	GTPase activity
HC658_RS08470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC658_RS08475	COG1564	THIamine pyrophosphokinase
HC658_RS08485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC658_RS08490	COG1302	Protein conserved in bacteria
HC658_RS08495	COG1461	Dihydroxyacetone kinase
HC658_RS08500	COG1760	l-serine dehydratase
HC658_RS08505	COG1760	l-serine dehydratase
HC658_RS08510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC658_RS08515	COG1349	DNA-binding transcription factor activity
HC658_RS08515	COG2050	protein possibly involved in aromatic compounds catabolism
HC658_RS08520	COG0416	fatty acid biosynthetic process
HC658_RS08525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS08540	COG0571	ribonuclease III activity
HC658_RS08545	COG1196	nuclear chromosome segregation
HC658_RS08550	COG0552	protein localization to endoplasmic reticulum
HC658_RS08560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC658_RS08565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC658_RS08570	COG0228	four-way junction DNA binding
HC658_RS08575	COG1837	Belongs to the UPF0109 family
HC658_RS08585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC658_RS08590	COG0336	Belongs to the RNA methyltransferase TrmD family
HC658_RS08595	COG0335	large ribosomal subunit rRNA binding
HC658_RS08600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC658_RS08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC658_RS08615	COG2257	FlhB HrpN YscU SpaS Family
HC658_RS08620	COG0045	succinate-CoA ligase (ADP-forming) activity
HC658_RS08625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HC658_RS08630	COG0758	DNA mediated transformation
HC658_RS08635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC658_RS08640	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC658_RS08645	COG4974	Belongs to the 'phage' integrase family
HC658_RS08650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC658_RS08655	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC658_RS08660	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC658_RS08665	COG1815	bacterial-type flagellum-dependent cell motility
HC658_RS08670	COG1558	bacterial-type flagellum-dependent cell motility
HC658_RS08675	COG1677	Flagellar hook-basal body complex protein FliE
HC658_RS08680	COG1766	The M ring may be actively involved in energy transduction
HC658_RS08685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_RS08690	COG1317	bacterial-type flagellum organization
HC658_RS08695	COG1157	protein secretion by the type III secretion system
HC658_RS08700	COG2882	bacterial-type flagellum organization
HC658_RS08705	COG3334	PFAM MgtE intracellular
HC658_RS08710	COG3144	bacterial-type flagellum assembly
HC658_RS08715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HC658_RS08720	COG4786	Flagellar basal body rod
HC658_RS08725	COG1582	Flagellar protein (FlbD)
HC658_RS08730	COG1580	Controls the rotational direction of flagella during chemotaxis
HC658_RS08735	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_RS08740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HC658_RS08740	COG1776	CheC inhibitor of MCP methylation
HC658_RS08745	COG2201	protein-glutamate methylesterase activity
HC658_RS08750	COG3190	flagellar
HC658_RS08755	COG1338	Plays a role in the flagellum-specific transport system
HC658_RS08760	COG1987	bacterial-type flagellum assembly
HC658_RS08765	COG1684	flagellar biosynthetic protein fliR
HC658_RS08770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC658_RS08775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HC658_RS08780	COG1419	protein localization to endoplasmic reticulum
HC658_RS08785	COG0455	bacterial-type flagellum organization
HC658_RS08790	COG2201	protein-glutamate methylesterase activity
HC658_RS08795	COG2198	Histidine kinase
HC658_RS08795	COG0643	Histidine kinase
HC658_RS08800	COG0835	chemotaxis
HC658_RS08805	COG1776	CheC inhibitor of MCP methylation
HC658_RS08810	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HC658_RS08815	COG1191	sigma factor activity
HC658_RS08825	COG0052	Belongs to the universal ribosomal protein uS2 family
HC658_RS08830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC658_RS08835	COG0528	UMP kinase activity
HC658_RS08840	COG0233	cytoplasmic translational termination
HC658_RS08845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC658_RS08850	COG4589	Belongs to the CDS family
HC658_RS08855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HC658_RS08860	COG0750	zinc metalloprotease
HC658_RS08865	COG0442	prolyl-tRNA aminoacylation
HC658_RS08870	COG2176	DNA-directed DNA polymerase activity
HC658_RS08875	COG0779	Required for maturation of 30S ribosomal subunits
HC658_RS08880	COG0195	Participates in both transcription termination and antitermination
HC658_RS08885	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC658_RS08890	COG1358	cellular component organization or biogenesis
HC658_RS08895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HC658_RS08900	COG1550	Protein conserved in bacteria
HC658_RS08905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC658_RS08910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC658_RS08915	COG0196	riboflavin kinase activity
HC658_RS08920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC658_RS08925	COG1185	polyribonucleotide nucleotidyltransferase activity
HC658_RS08930	COG0726	polysaccharide deacetylase
HC658_RS08935	COG0612	Peptidase, M16
HC658_RS08940	COG1873	PFAM PRC-barrel domain
HC658_RS08945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC658_RS08950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC658_RS08955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC658_RS08960	COG0527	aspartate kinase activity
HC658_RS08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC658_RS08970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HC658_RS08975	COG0740	serine-type endopeptidase activity
HC658_RS08985	COG1674	ftsk spoiiie
HC658_RS08985	COG4980	gas vesicle protein
HC658_RS08990	COG2188	Transcriptional regulator
HC658_RS08995	COG2814	Major facilitator Superfamily
HC658_RS09000	COG0612	Peptidase, M16
HC658_RS09005	COG0612	Peptidase, M16
HC658_RS09010	COG0300	oxidoreductase activity
HC658_RS09025	COG1426	Protein conserved in bacteria
HC658_RS09030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC658_RS09035	COG1058	Belongs to the CinA family
HC658_RS09035	COG1546	Belongs to the CinA family
HC658_RS09040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC658_RS09045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_RS09050	COG1418	mRNA catabolic process
HC658_RS09055	COG1692	metallophosphoesterase
HC658_RS09060	COG2359	stage V sporulation protein S
HC658_RS09065	COG1063	alcohol dehydrogenase
HC658_RS09070	COG0156	8-amino-7-oxononanoate synthase activity
HC658_RS09075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC658_RS09080	COG4550	Control of competence regulator ComK, YlbF/YmcA
HC658_RS09090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC658_RS09095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC658_RS09110	COG3226	Transcriptional regulator
HC658_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS09125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_RS09130	COG3321	synthase
HC658_RS09135	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC658_RS09135	COG2070	2-Nitropropane dioxygenase
HC658_RS09140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_RS09145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC658_RS09150	COG3425	synthase
HC658_RS09155	COG1024	Enoyl-CoA hydratase
HC658_RS09160	COG1024	Enoyl-CoA hydratase
HC658_RS09165	COG0300	oxidoreductase activity
HC658_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09165	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS09165	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS09165	COG3321	synthase
HC658_RS09170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_RS09170	COG4221	oxidoreductase activity
HC658_RS09170	COG3321	synthase
HC658_RS09170	COG0300	oxidoreductase activity
HC658_RS09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_RS09175	COG3321	synthase
HC658_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS09175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_RS09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS09180	COG3321	synthase
HC658_RS09180	COG4221	oxidoreductase activity
HC658_RS09185	COG3321	synthase
HC658_RS09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_RS09185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC658_RS09185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HC658_RS09190	COG2124	cytochrome p450
HC658_RS09200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS09205	COG1404	Belongs to the peptidase S8 family
HC658_RS09215	COG4195	phage-related replication protein
HC658_RS09220	COG1764	response to oxidative stress
HC658_RS09225	COG2076	Multidrug Resistance protein
HC658_RS09230	COG2076	Multidrug Resistance protein
HC658_RS09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC658_RS09250	COG1923	regulation of RNA biosynthetic process
HC658_RS09265	COG1780	Probably involved in ribonucleotide reductase function
HC658_RS09270	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC658_RS09275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC658_RS09280	COG4112	unkown
HC658_RS09285	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS09290	COG0464	growth
HC658_RS09295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC658_RS09300	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HC658_RS09305	COG0789	Transcriptional regulator
HC658_RS09310	COG0174	glutamine synthetase
HC658_RS09330	COG4282	regulation of fungal-type cell wall biogenesis
HC658_RS09340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS09370	COG0135	phosphoribosylanthranilate isomerase activity
HC658_RS09375	COG2211	Major facilitator Superfamily
HC658_RS09380	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_RS09385	COG1940	carbohydrate kinase activity
HC658_RS09390	COG2115	Belongs to the xylose isomerase family
HC658_RS09395	COG1070	Carbohydrate kinase
HC658_RS09405	COG1525	nuclease
HC658_RS09410	COG2814	Major facilitator Superfamily
HC658_RS09415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC658_RS09425	COG0756	dUTP diphosphatase activity
HC658_RS09465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HC658_RS09480	COG3832	glyoxalase III activity
HC658_RS09490	COG0697	spore germination
HC658_RS09495	COG0531	amino acid
HC658_RS09525	COG4195	phage-related replication protein
HC658_RS09535	COG0346	lactoylglutathione lyase activity
HC658_RS09540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC658_RS09545	COG1388	LysM domain
HC658_RS09550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_RS09555	COG4224	UPF0291 protein
HC658_RS09560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HC658_RS09570	COG3763	UPF0154 protein
HC658_RS09580	COG0785	Cytochrome C biogenesis protein
HC658_RS09585	COG2201	protein-glutamate methylesterase activity
HC658_RS09590	COG4846	Membrane protein involved in cytochrome C biogenesis
HC658_RS09600	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_RS09615	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HC658_RS09620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS09640	COG0824	Thioesterase
HC658_RS09650	COG4841	protein insertion into membrane
HC658_RS09655	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC658_RS09660	COG1832	CoA-binding protein
HC658_RS09665	COG0187	DNA topoisomerase II activity
HC658_RS09670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HC658_RS09680	COG1115	amino acid carrier protein
HC658_RS09685	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HC658_RS09695	COG5520	Belongs to the glycosyl hydrolase 30 family
HC658_RS09700	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_RS09705	COG2246	polysaccharide biosynthetic process
HC658_RS09710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_RS09715	COG0586	Pfam SNARE associated Golgi protein
HC658_RS09720	COG2404	hydrolase activity, acting on ester bonds
HC658_RS09725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC658_RS09730	COG1024	Enoyl-CoA hydratase
HC658_RS09735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC658_RS09740	COG0511	ligase activity, forming carbon-carbon bonds
HC658_RS09745	COG0439	Biotin carboxylase
HC658_RS09750	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS09755	COG1960	acyl-CoA dehydrogenase activity
HC658_RS09770	COG1649	PFAM Uncharacterised BCR, COG1649
HC658_RS09780	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HC658_RS09780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS09805	COG2027	D-alanyl-D-alanine carboxypeptidase
HC658_RS09810	COG2017	converts alpha-aldose to the beta-anomer
HC658_RS09815	COG0534	Mate efflux family protein
HC658_RS09830	COG0582	viral genome integration into host DNA
HC658_RS09835	COG0166	Belongs to the GPI family
HC658_RS09840	COG0405	Gamma-glutamyltransferase
HC658_RS09845	COG0583	DNA-binding transcription factor activity
HC658_RS09850	COG0604	alcohol dehydrogenase
HC658_RS09855	COG0493	'glutamate synthase
HC658_RS09860	COG0067	glutamate synthase
HC658_RS09860	COG0069	glutamate synthase activity
HC658_RS09860	COG0070	glutamate synthase
HC658_RS09865	COG0583	DNA-binding transcription factor activity
HC658_RS09870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC658_RS09875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_RS09885	COG0300	oxidoreductase activity
HC658_RS09890	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC658_RS09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC658_RS09905	COG2814	Major facilitator Superfamily
HC658_RS09910	COG1070	Carbohydrate kinase
HC658_RS09915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC658_RS09920	COG0243	molybdopterin cofactor binding
HC658_RS09950	COG0840	transmembrane signaling receptor activity
HC658_RS09950	COG5278	phosphoserine phosphatase activity
HC658_RS09955	COG2368	4-hydroxyphenylacetate
HC658_RS09960	COG4305	rare lipoprotein A
HC658_RS09965	COG3619	membrane
HC658_RS09970	COG3866	Pectate lyase
HC658_RS09975	COG2135	peptidase activity
HC658_RS09985	COG2140	Oxalate decarboxylase
HC658_RS10010	COG2720	vancomycin resistance protein
HC658_RS10025	COG3739	integral membrane protein
HC658_RS10030	COG0583	DNA-binding transcription factor activity
HC658_RS10035	COG0697	spore germination
HC658_RS10045	COG0693	protein deglycase activity
HC658_RS10050	COG2367	Beta-lactamase
HC658_RS10075	COG0574	Belongs to the PEP-utilizing enzyme family
HC658_RS10075	COG3848	Pyruvate phosphate dikinase
HC658_RS10080	COG0726	polysaccharide deacetylase
HC658_RS10085	COG2314	TM2 domain
HC658_RS10090	COG1396	sequence-specific DNA binding
HC658_RS10105	COG2135	peptidase activity
HC658_RS10140	COG0457	Tetratricopeptide repeat
HC658_RS10165	COG5290	Psort location Cytoplasmic, score
HC658_RS10190	COG5444	nuclease activity
HC658_RS10195	COG4282	regulation of fungal-type cell wall biogenesis
HC658_RS10200	COG1231	oxidoreductase activity
HC658_RS10205	COG5434	Belongs to the glycosyl hydrolase 28 family
HC658_RS10210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_RS10215	COG0662	Cupin 2, conserved barrel domain protein
HC658_RS10215	COG2207	Transcriptional regulator
HC658_RS10220	COG0456	acetyltransferase
HC658_RS10225	COG1309	transcriptional regulator
HC658_RS10230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS10235	COG3708	Transcriptional regulator
HC658_RS10240	COG2378	regulation of single-species biofilm formation
HC658_RS10250	COG0640	Transcriptional regulator
HC658_RS10255	COG0741	lytic transglycosylase activity
HC658_RS10260	COG2322	membrane
HC658_RS10275	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC658_RS10280	COG3239	Fatty acid desaturase
HC658_RS10285	COG4585	Histidine kinase
HC658_RS10290	COG2197	response regulator
HC658_RS10295	COG1388	LysM domain
HC658_RS10295	COG3584	3D domain protein
HC658_RS10300	COG0514	ATP-dependent DNA helicase (RecQ)
HC658_RS10310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC658_RS10315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_RS10330	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_RS10355	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS10360	COG1657	PFAM Prenyltransferase squalene oxidase
HC658_RS10365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC658_RS10370	COG0733	neurotransmitter:sodium symporter activity
HC658_RS10375	COG0385	Bile acid
HC658_RS10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_RS10385	COG0567	Dehydrogenase, E1 component
HC658_RS10390	COG4548	von Willebrand factor, type A
HC658_RS10395	COG0714	Associated with various cellular activities
HC658_RS10400	COG2032	superoxide dismutase activity
HC658_RS10405	COG0791	NLP P60 protein
HC658_RS10405	COG1388	LysM domain
HC658_RS10410	COG1819	glycosyl
HC658_RS10415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HC658_RS10420	COG0534	Mate efflux family protein
HC658_RS10425	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS10430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_RS10435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_RS10445	COG2962	Rard protein
HC658_RS10460	COG2610	gluconate transmembrane transporter activity
HC658_RS10465	COG1942	4-Oxalocrotonate Tautomerase
HC658_RS10470	COG1733	regulation of RNA biosynthetic process
HC658_RS10475	COG0778	Nitroreductase
HC658_RS10480	COG0400	carboxylic ester hydrolase activity
HC658_RS10485	COG0346	lactoylglutathione lyase activity
HC658_RS10495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_RS10500	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS10500	COG0793	Belongs to the peptidase S41A family
HC658_RS10505	COG2226	methyltransferase
HC658_RS10515	COG1876	peptidase activity
HC658_RS10520	COG0813	purine-nucleoside phosphorylase activity
HC658_RS10535	COG0671	phosphoesterase, PA-phosphatase related
HC658_RS10555	COG4479	Belongs to the UPF0346 family
HC658_RS10565	COG1509	lysine 2,3-aminomutase activity
HC658_RS10570	COG0456	acetyltransferase
HC658_RS10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_RS10580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC658_RS10585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC658_RS10590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_RS10605	COG0456	acetyltransferase
HC658_RS10610	COG0463	Glycosyl transferase, family 2
HC658_RS10625	COG4641	Protein conserved in bacteria
HC658_RS10630	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HC658_RS10635	COG1086	Polysaccharide biosynthesis protein
HC658_RS10640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC658_RS10645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC658_RS10650	COG1846	Transcriptional regulator
HC658_RS10655	COG0534	Mate efflux family protein
HC658_RS10665	COG4698	Protein conserved in bacteria
HC658_RS10670	COG2755	lipolytic protein G-D-S-L family
HC658_RS10675	COG1999	signal sequence binding
HC658_RS10685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HC658_RS10690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC658_RS10695	COG1272	protein, Hemolysin III
HC658_RS10700	COG0204	Acyl-transferase
HC658_RS10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_RS10710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC658_RS10715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC658_RS10725	COG2521	methyltransferase
HC658_RS10725	COG2136	Putative SAM-dependent methyltransferase
HC658_RS10735	COG0129	dihydroxy-acid dehydratase activity
HC658_RS10740	COG1413	lyase activity
HC658_RS10745	COG1418	mRNA catabolic process
HC658_RS10750	COG0386	Belongs to the glutathione peroxidase family
HC658_RS10755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HC658_RS10760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HC658_RS10770	COG1278	Cold shock
HC658_RS10790	COG0328	RNA-DNA hybrid ribonuclease activity
HC658_RS10795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HC658_RS10800	COG0328	RNA-DNA hybrid ribonuclease activity
HC658_RS10810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_RS10825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC658_RS10835	COG1755	Isoprenylcysteine carboxyl methyltransferase
HC658_RS10840	COG3424	synthase
HC658_RS10845	COG2233	PERMEase
HC658_RS10850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_RS10855	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC658_RS10865	COG0800	Aldolase
HC658_RS10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_RS10875	COG1609	Transcriptional regulator
HC658_RS10880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC658_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS10890	COG1199	ATP-dependent helicase activity
HC658_RS10905	COG0116	Belongs to the methyltransferase superfamily
HC658_RS10920	COG4474	Belongs to the UPF0398 family
HC658_RS10935	COG3359	exonuclease
HC658_RS10940	COG1111	helicase
HC658_RS10940	COG1205	dead DEAH box helicase
HC658_RS10945	COG2190	(PTS) system
HC658_RS10950	COG0071	Belongs to the small heat shock protein (HSP20) family
HC658_RS10985	COG3331	DNA recombination
HC658_RS10990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_RS10990	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC658_RS11000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC658_RS11005	COG3935	DnaD domain protein
HC658_RS11010	COG0017	Asparaginyl-tRNA synthetase
HC658_RS11015	COG0436	Aminotransferase
HC658_RS11020	COG5353	protein conserved in bacteria
HC658_RS11030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC658_RS11030	COG1199	ATP-dependent helicase activity
HC658_RS11035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HC658_RS11040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HC658_RS11045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HC658_RS11050	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC658_RS11050	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC658_RS11055	COG0617	tRNA 3'-terminal CCA addition
HC658_RS11060	COG0438	transferase activity, transferring glycosyl groups
HC658_RS11065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HC658_RS11070	COG1803	Methylglyoxal synthase
HC658_RS11075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC658_RS11080	COG1694	Mazg nucleotide pyrophosphohydrolase
HC658_RS11085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS11095	COG4347	Protein of unknown function (DUF1405)
HC658_RS11100	COG2010	Cytochrome c
HC658_RS11100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC658_RS11105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HC658_RS11110	COG0723	plastoquinol--plastocyanin reductase activity
HC658_RS11120	COG5582	Belongs to the UPF0302 family
HC658_RS11125	COG0457	Tetratricopeptide repeat
HC658_RS11130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC658_RS11135	COG0287	Prephenate dehydrogenase
HC658_RS11140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC658_RS11145	COG0159	tryptophan synthase activity
HC658_RS11150	COG0133	tryptophan synthase activity
HC658_RS11155	COG0135	phosphoribosylanthranilate isomerase activity
HC658_RS11165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HC658_RS11170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HC658_RS11175	COG4401	Chorismate mutase type I
HC658_RS11180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HC658_RS11185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC658_RS11190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HC658_RS11195	COG0105	UTP biosynthetic process
HC658_RS11200	COG0142	geranyltranstransferase activity
HC658_RS11205	COG2226	methyltransferase
HC658_RS11210	COG0142	geranyltranstransferase activity
HC658_RS11220	COG0302	gtp cyclohydrolase
HC658_RS11225	COG0776	regulation of translation
HC658_RS11230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HC658_RS11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC658_RS11250	COG1160	GTP binding
HC658_RS11275	COG1304	FMN binding
HC658_RS11280	COG0539	negative regulation of cytoplasmic translation
HC658_RS11285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC658_RS11295	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HC658_RS11300	COG2959	enzyme of heme biosynthesis
HC658_RS11305	COG3773	Cell wall hydrolase
HC658_RS11305	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS11310	COG2339	peptidase activity
HC658_RS11315	COG0492	ferredoxin-NADP+ reductase activity
HC658_RS11320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_RS11325	COG4862	establishment of competence for transformation
HC658_RS11330	COG1408	metallophosphoesterase
HC658_RS11340	COG1388	LysM domain
HC658_RS11345	COG1266	CAAX protease self-immunity
HC658_RS11350	COG0514	ATP-dependent DNA helicase (RecQ)
HC658_RS11355	COG4955	Helix-turn-helix domain
HC658_RS11360	COG1141	Ferredoxin
HC658_RS11365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC658_RS11370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC658_RS11375	COG0710	3-dehydroquinate dehydratase activity
HC658_RS11385	COG1595	DNA-templated transcription, initiation
HC658_RS11390	COG5002	protein histidine kinase activity
HC658_RS11395	COG0745	RESPONSE REGULATOR receiver
HC658_RS11400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC658_RS11405	COG1333	cytochrome c biogenesis protein
HC658_RS11410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS11415	COG1187	pseudouridine synthase activity
HC658_RS11420	COG0700	Nucleoside recognition
HC658_RS11425	COG2715	membrane protein required for spore maturation
HC658_RS11430	COG1686	Belongs to the peptidase S11 family
HC658_RS11440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC658_RS11445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC658_RS11450	COG1547	Domain of unknown function (DUF309)
HC658_RS11455	COG0456	acetyltransferase
HC658_RS11460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HC658_RS11465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC658_RS11465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HC658_RS11470	COG0307	riboflavin synthase, alpha
HC658_RS11475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC658_RS11475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HC658_RS11485	COG0681	Belongs to the peptidase S26 family
HC658_RS11495	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HC658_RS11510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HC658_RS11515	COG4086	secreted protein
HC658_RS11520	COG0019	diaminopimelate decarboxylase activity
HC658_RS11525	COG0697	spore germination
HC658_RS11540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC658_RS11560	COG1191	sigma factor activity
HC658_RS11565	COG2172	sigma factor antagonist activity
HC658_RS11570	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS11575	COG1686	Belongs to the peptidase S11 family
HC658_RS11580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HC658_RS11585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC658_RS11590	COG4974	Belongs to the 'phage' integrase family
HC658_RS11600	COG0735	belongs to the Fur family
HC658_RS11605	COG1300	Membrane
HC658_RS11615	COG0281	malic enzyme
HC658_RS11620	COG1757	Na H antiporter
HC658_RS11625	COG1027	Aspartate ammonia-lyase
HC658_RS11630	COG0252	asparaginase activity
HC658_RS11635	COG1396	sequence-specific DNA binding
HC658_RS11640	COG1379	DNA repair
HC658_RS11645	COG0494	nUDIX hydrolase
HC658_RS11655	COG0667	Aldo Keto reductase
HC658_RS11665	COG1073	alpha beta
HC658_RS11675	COG4918	Iron-sulphur cluster biosynthesis
HC658_RS11680	COG0456	acetyltransferase
HC658_RS11680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HC658_RS11685	COG2329	Antibiotic biosynthesis monooxygenase
HC658_RS11690	COG0456	acetyltransferase
HC658_RS11700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_RS11710	COG2211	Major facilitator Superfamily
HC658_RS11720	COG0346	lactoylglutathione lyase activity
HC658_RS11725	COG1072	(Pantothenic acid kinase))
HC658_RS11730	COG3048	D-serine ammonia-lyase activity
HC658_RS11735	COG0300	oxidoreductase activity
HC658_RS11740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS11745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_RS11750	COG4187	Peptidase family M20/M25/M40
HC658_RS11755	COG1902	pentaerythritol trinitrate reductase activity
HC658_RS11760	COG0596	Alpha beta hydrolase
HC658_RS11770	COG1234	tRNA 3'-trailer cleavage
HC658_RS11775	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC658_RS11780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC658_RS11785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC658_RS11795	COG0706	membrane insertase activity
HC658_RS11805	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC658_RS11810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HC658_RS11815	COG0346	lactoylglutathione lyase activity
HC658_RS11825	COG1376	ErfK ybiS ycfS ynhG family protein
HC658_RS11830	COG4129	membrane
HC658_RS11835	COG1126	abc transporter atp-binding protein
HC658_RS11840	COG0765	amino acid transport
HC658_RS11845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS11855	COG1597	lipid kinase activity
HC658_RS11860	COG2814	Major facilitator Superfamily
HC658_RS11865	COG0789	Transcriptional regulator
HC658_RS11865	COG4978	Transcriptional regulator
HC658_RS11870	COG0508	dehydrogenase complex catalyzes the overall conversion of
HC658_RS11875	COG0022	dehydrogenase e1 component
HC658_RS11880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HC658_RS11885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC658_RS11890	COG3426	butyrate kinase activity
HC658_RS11895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_RS11900	COG0280	phosphate acetyltransferase
HC658_RS11905	COG3829	transcription factor binding
HC658_RS11905	COG3290	protein histidine kinase activity
HC658_RS11915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HC658_RS11920	COG2079	MmgE PrpD family protein
HC658_RS11925	COG0372	Belongs to the citrate synthase family
HC658_RS11930	COG1960	acyl-CoA dehydrogenase activity
HC658_RS11935	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC658_RS11940	COG0183	Belongs to the thiolase family
HC658_RS11945	COG0584	glycerophosphoryl diester phosphodiesterase
HC658_RS11950	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS11965	COG1902	pentaerythritol trinitrate reductase activity
HC658_RS11970	COG0745	RESPONSE REGULATOR receiver
HC658_RS11975	COG0750	zinc metalloprotease
HC658_RS11980	COG0497	DNA recombination
HC658_RS11985	COG1438	arginine binding
HC658_RS11990	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC658_RS11995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC658_RS12000	COG0142	geranyltranstransferase activity
HC658_RS12005	COG1722	exodeoxyribonuclease VII activity
HC658_RS12010	COG1570	exodeoxyribonuclease VII activity
HC658_RS12015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC658_RS12020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC658_RS12025	COG1302	Protein conserved in bacteria
HC658_RS12030	COG0439	Biotin carboxylase
HC658_RS12035	COG0511	ligase activity, forming carbon-carbon bonds
HC658_RS12075	COG3854	ATPases associated with a variety of cellular activities
HC658_RS12085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC658_RS12090	COG0006	proline dipeptidase activity
HC658_RS12095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HC658_RS12105	COG3872	metal-dependent enzyme
HC658_RS12115	COG1752	Esterase of the alpha-beta hydrolase superfamily
HC658_RS12120	COG1321	iron dependent repressor
HC658_RS12125	COG0095	Lipoate-protein ligase
HC658_RS12130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_RS12135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC658_RS12140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HC658_RS12145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HC658_RS12150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC658_RS12165	COG1396	sequence-specific DNA binding
HC658_RS12175	COG0681	Belongs to the peptidase S26 family
HC658_RS12200	COG4940	Competence protein ComGF
HC658_RS12210	COG4970	Tfp pilus assembly protein FimT
HC658_RS12215	COG4537	Required for transformation and DNA binding
HC658_RS12220	COG1459	type II secretion system
HC658_RS12225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC658_RS12230	COG0517	IMP dehydrogenase activity
HC658_RS12235	COG0598	Magnesium transport protein CorA
HC658_RS12240	COG1253	flavin adenine dinucleotide binding
HC658_RS12245	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS12255	COG1393	Belongs to the ArsC family
HC658_RS12265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS12275	COG0011	TIGRFAM Protein of
HC658_RS12285	COG2866	Carboxypeptidase
HC658_RS12290	COG1368	sulfuric ester hydrolase activity
HC658_RS12295	COG1940	carbohydrate kinase activity
HC658_RS12300	COG4483	Protein conserved in bacteria
HC658_RS12305	COG0705	Rhomboid family
HC658_RS12305	COG0457	Tetratricopeptide repeat
HC658_RS12315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC658_RS12325	COG0438	transferase activity, transferring glycosyl groups
HC658_RS12340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC658_RS12345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_RS12350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC658_RS12355	COG0581	inorganic phosphate transmembrane transporter activity
HC658_RS12360	COG0573	inorganic phosphate transmembrane transporter activity
HC658_RS12365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC658_RS12375	COG0477	Major facilitator Superfamily
HC658_RS12380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC658_RS12385	COG2839	Protein conserved in bacteria
HC658_RS12390	COG5521	maltodextrose utilization protein MalA
HC658_RS12400	COG1388	LysM domain
HC658_RS12405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HC658_RS12410	COG4709	membrane
HC658_RS12415	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HC658_RS12420	COG0735	belongs to the Fur family
HC658_RS12425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS12435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC658_RS12440	COG0513	Belongs to the DEAD box helicase family
HC658_RS12450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HC658_RS12455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC658_RS12460	COG2384	SAM-dependent methyltransferase
HC658_RS12465	COG2010	Cytochrome c
HC658_RS12470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC658_RS12475	COG0358	DNA primase activity
HC658_RS12480	COG1671	Belongs to the UPF0178 family
HC658_RS12485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC658_RS12490	COG0517	IMP dehydrogenase activity
HC658_RS12495	COG0751	glycine-tRNA ligase activity
HC658_RS12500	COG0752	glycyl-tRNA synthetase alpha subunit
HC658_RS12505	COG1381	Involved in DNA repair and RecF pathway recombination
HC658_RS12515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC658_RS12520	COG0295	cytidine deaminase activity
HC658_RS12525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC658_RS12530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC658_RS12535	COG1480	7TM receptor with intracellular HD hydrolase
HC658_RS12540	COG1702	phosphate starvation-inducible protein PhoH
HC658_RS12545	COG0561	phosphatase activity
HC658_RS12560	COG4864	UPF0365 protein
HC658_RS12565	COG1030	water channel activity
HC658_RS12570	COG1610	YqeY-like protein
HC658_RS12580	COG1283	sodium-dependent phosphate transmembrane transporter activity
HC658_RS12585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HC658_RS12590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC658_RS12595	COG2264	protein methyltransferase activity
HC658_RS12600	COG0484	heat shock protein binding
HC658_RS12605	COG0443	Heat shock 70 kDa protein
HC658_RS12610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC658_RS12615	COG1420	regulation of RNA biosynthetic process
HC658_RS12620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC658_RS12625	COG0481	GTPase activity
HC658_RS12635	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS12640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HC658_RS12645	COG0268	Binds directly to 16S ribosomal RNA
HC658_RS12650	COG1466	dna polymerase III delta subunit
HC658_RS12665	COG0658	competence protein
HC658_RS12665	COG2333	competence protein COMEC
HC658_RS12670	COG2131	deaminase
HC658_RS12675	COG1596	polysaccharide export
HC658_RS12675	COG1555	photosystem II stabilization
HC658_RS12680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC658_RS12685	COG2226	methyltransferase
HC658_RS12690	COG0799	negative regulation of ribosome biogenesis
HC658_RS12695	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC658_RS12700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC658_RS12705	COG1534	Rna-binding protein
HC658_RS12710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC658_RS12715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC658_RS12720	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC658_RS12730	COG2755	lipolytic protein G-D-S-L family
HC658_RS12735	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS12735	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_RS12740	COG0398	Pfam SNARE associated Golgi protein
HC658_RS12755	COG3209	COG3209 Rhs family protein
HC658_RS12765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC658_RS12770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_RS12775	COG0798	PFAM Bile acid sodium symporter
HC658_RS12780	COG0346	lactoylglutathione lyase activity
HC658_RS12785	COG0640	Transcriptional regulator
HC658_RS12790	COG3403	YqcI/YcgG family
HC658_RS12795	COG0457	Tetratricopeptide repeat
HC658_RS12810	COG5444	nuclease activity
HC658_RS12835	COG5632	N-Acetylmuramoyl-L-alanine amidase
HC658_RS12835	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS12840	COG4824	toxin secretion phage lysis holin
HC658_RS12870	COG3778	Protein conserved in bacteria
HC658_RS12875	COG3299	homolog of phage Mu protein gp47
HC658_RS12880	COG3628	GPW Gp25 family protein
HC658_RS12890	COG4193	domain, Protein
HC658_RS12895	COG1652	LysM domain
HC658_RS12900	COG5280	Phage tail tape measure protein TP901
HC658_RS12900	COG3953	SLT domain
HC658_RS12965	COG4653	Phage capsid family
HC658_RS12970	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HC658_RS12980	COG2369	cell adhesion
HC658_RS12985	COG5518	Phage portal protein
HC658_RS12990	COG1783	phage Terminase large subunit
HC658_RS12995	COG5484	DNA packaging
HC658_RS13005	COG3677	Transposase
HC658_RS13020	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HC658_RS13030	COG1484	DNA-dependent DNA replication
HC658_RS13035	COG3935	DnaD domain protein
HC658_RS13040	COG3723	Recombinational DNA repair protein, rece pathway
HC658_RS13045	COG5377	YqaJ viral recombinase family
HC658_RS13075	COG1476	TRANSCRIPTIONal
HC658_RS13080	COG3620	sequence-specific DNA binding
HC658_RS13090	COG0563	adenylate kinase activity
HC658_RS13095	COG2856	Zn peptidase
HC658_RS13120	COG3223	Belongs to the PsiE family
HC658_RS13125	COG5002	protein histidine kinase activity
HC658_RS13125	COG0642	Histidine kinase
HC658_RS13130	COG0745	RESPONSE REGULATOR receiver
HC658_RS13135	COG2311	Membrane
HC658_RS13145	COG0454	-acetyltransferase
HC658_RS13150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC658_RS13160	COG0730	response to heat
HC658_RS13165	COG0425	Belongs to the sulfur carrier protein TusA family
HC658_RS13170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_RS13170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS13180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_RS13180	COG0425	Belongs to the sulfur carrier protein TusA family
HC658_RS13190	COG2210	Belongs to the sulfur carrier protein TusA family
HC658_RS13195	COG1937	Protein conserved in bacteria
HC658_RS13200	COG0662	Cupin 2, conserved barrel domain protein
HC658_RS13210	COG4978	Transcriptional regulator
HC658_RS13210	COG0789	Transcriptional regulator
HC658_RS13215	COG2814	Major facilitator Superfamily
HC658_RS13220	COG0456	acetyltransferase
HC658_RS13225	COG1253	flavin adenine dinucleotide binding
HC658_RS13235	COG0697	spore germination
HC658_RS13240	COG0583	DNA-binding transcription factor activity
HC658_RS13245	COG2072	flavoprotein involved in K transport
HC658_RS13250	COG1230	cation diffusion facilitator family transporter
HC658_RS13255	COG1942	4-Oxalocrotonate Tautomerase
HC658_RS13260	COG0583	DNA-binding transcription factor activity
HC658_RS13270	COG1114	Component of the transport system for branched-chain amino acids
HC658_RS13275	COG1687	branched-chain amino acid
HC658_RS13280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC658_RS13285	COG1522	sequence-specific DNA binding
HC658_RS13295	COG2124	cytochrome p450
HC658_RS13305	COG1335	isochorismatase
HC658_RS13320	COG2318	DinB family
HC658_RS13330	COG2070	2-Nitropropane dioxygenase
HC658_RS13355	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC658_RS13360	COG1595	DNA-templated transcription, initiation
HC658_RS13365	COG0667	Aldo Keto reductase
HC658_RS13370	COG2851	Citrate transporter
HC658_RS13375	COG0583	DNA-binding transcription factor activity
HC658_RS13380	COG2828	Protein conserved in bacteria
HC658_RS13385	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS13390	COG5566	PFAM Mor transcription activator
HC658_RS13395	COG0596	Alpha beta hydrolase
HC658_RS13400	COG4991	sh3 domain protein
HC658_RS13405	COG4991	sh3 domain protein
HC658_RS13415	COG0346	lactoylglutathione lyase activity
HC658_RS13425	COG5577	PFAM Coat F domain
HC658_RS13430	COG1063	alcohol dehydrogenase
HC658_RS13440	COG5577	PFAM Coat F domain
HC658_RS13445	COG0789	Transcriptional regulator
HC658_RS13455	COG1064	alcohol dehydrogenase
HC658_RS13460	COG0693	protein deglycase activity
HC658_RS13465	COG1621	beta-fructofuranosidase activity
HC658_RS13470	COG3716	PTS system mannose fructose sorbose family IID component
HC658_RS13475	COG3715	PTS system
HC658_RS13480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS13485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS13490	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC658_RS13490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC658_RS13500	COG1113	amino acid transport
HC658_RS13505	COG1280	lysine exporter protein (LysE YggA)
HC658_RS13510	COG1378	Sugar-specific transcriptional regulator TrmB
HC658_RS13515	COG1595	DNA-templated transcription, initiation
HC658_RS13525	COG2755	lipolytic protein G-D-S-L family
HC658_RS13525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HC658_RS13535	COG2124	cytochrome p450
HC658_RS13535	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_RS13540	COG1309	transcriptional regulator
HC658_RS13545	COG2226	methyltransferase
HC658_RS13560	COG2116	formate transmembrane transporter activity
HC658_RS13565	COG5609	conserved protein (DUF2294)
HC658_RS13570	COG3383	formate dehydrogenase (NAD+) activity
HC658_RS13575	COG2427	Protein of unknown function (DUF1641)
HC658_RS13585	COG0626	cystathionine gamma-synthase activity
HC658_RS13590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_RS13595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC658_RS13600	COG2226	methyltransferase
HC658_RS13615	COG0768	penicillin binding
HC658_RS13620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC658_RS13625	COG0572	uridine kinase
HC658_RS13640	COG4122	O-methyltransferase activity
HC658_RS13645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC658_RS13650	COG3906	Belongs to the UPF0473 family
HC658_RS13655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC658_RS13660	COG4472	Bacterial protein of unknown function (DUF965)
HC658_RS13665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC658_RS13670	COG0628	permease
HC658_RS13675	COG1126	abc transporter atp-binding protein
HC658_RS13680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS13685	COG0765	amino acid transport
HC658_RS13690	COG0765	amino acid transport
HC658_RS13705	COG3881	PFAM PRC-barrel domain
HC658_RS13710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC658_RS13715	COG0457	Tetratricopeptide repeat
HC658_RS13720	COG0482	sulfurtransferase activity
HC658_RS13725	COG1104	cysteine desulfurase activity
HC658_RS13730	COG1959	2 iron, 2 sulfur cluster binding
HC658_RS13735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC658_RS13740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HC658_RS13750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC658_RS13755	COG0124	histidyl-tRNA synthetase
HC658_RS13765	COG4991	sh3 domain protein
HC658_RS13765	COG3103	Sh3 type 3 domain protein
HC658_RS13765	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS13770	COG1490	D-aminoacyl-tRNA deacylase activity
HC658_RS13775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC658_RS13780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC658_RS13785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC658_RS13785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC658_RS13790	COG5416	Lipopolysaccharide assembly protein A domain
HC658_RS13795	COG0490	domain, Protein
HC658_RS13800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC658_RS13800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HC658_RS13810	COG2244	polysaccharide biosynthetic process
HC658_RS13815	COG2323	membrane
HC658_RS13825	COG1862	Preprotein translocase
HC658_RS13830	COG0343	queuine tRNA-ribosyltransferase activity
HC658_RS13835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC658_RS13845	COG2255	four-way junction helicase activity
HC658_RS13850	COG0632	four-way junction helicase activity
HC658_RS13860	COG2814	Major facilitator Superfamily
HC658_RS13865	COG0673	inositol 2-dehydrogenase activity
HC658_RS13870	COG2112	serine threonine protein kinase
HC658_RS13890	COG1115	amino acid carrier protein
HC658_RS13895	COG0217	transcriptional regulatory protein
HC658_RS13905	COG1388	LysM domain
HC658_RS13910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HC658_RS13915	COG0157	Belongs to the NadC ModD family
HC658_RS13920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HC658_RS13925	COG1104	cysteine desulfurase activity
HC658_RS13930	COG1827	regulation of RNA biosynthetic process
HC658_RS13935	COG0077	Prephenate dehydratase
HC658_RS13940	COG4492	Belongs to the UPF0735 family
HC658_RS13945	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC658_RS13950	COG3290	protein histidine kinase activity
HC658_RS13960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC658_RS13965	COG2868	ribosomal protein
HC658_RS13970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC658_RS13975	COG1994	Peptidase M50
HC658_RS13980	COG0739	heme binding
HC658_RS13985	COG2894	cell division
HC658_RS13990	COG0850	regulation of cytokinetic process
HC658_RS13995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HC658_RS14005	COG1077	Cell shape determining protein MreB Mrl
HC658_RS14010	COG2003	Belongs to the UPF0758 family
HC658_RS14015	COG0424	maF-like protein
HC658_RS14025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC658_RS14030	COG0285	dihydrofolate synthase activity
HC658_RS14035	COG0525	valine-tRNA ligase activity
HC658_RS14045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_RS14050	COG1388	LysM domain
HC658_RS14055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HC658_RS14060	COG0113	porphobilinogen synthase activity
HC658_RS14065	COG1587	Uroporphyrinogen-III synthase
HC658_RS14070	COG0181	hydroxymethylbilane synthase activity
HC658_RS14075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HC658_RS14080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HC658_RS14090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC658_RS14095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HC658_RS14100	COG1067	ATP-dependent peptidase activity
HC658_RS14100	COG0470	DNA polymerase III
HC658_RS14105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC658_RS14110	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC658_RS14115	COG1477	protein flavinylation
HC658_RS14115	COG0457	Tetratricopeptide repeat
HC658_RS14120	COG0066	3-isopropylmalate dehydratase activity
HC658_RS14125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HC658_RS14130	COG0473	3-isopropylmalate dehydrogenase activity
HC658_RS14135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HC658_RS14140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HC658_RS14145	COG0440	acetolactate synthase activity
HC658_RS14150	COG0028	Belongs to the TPP enzyme family
HC658_RS14160	COG0454	-acetyltransferase
HC658_RS14165	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC658_RS14175	COG0622	Phosphoesterase
HC658_RS14180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HC658_RS14185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC658_RS14190	COG5401	PFAM Sporulation and spore germination
HC658_RS14195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC658_RS14200	COG1846	Transcriptional regulator
HC658_RS14205	COG2197	response regulator
HC658_RS14210	COG0824	Thioesterase
HC658_RS14215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HC658_RS14220	COG1053	succinate dehydrogenase
HC658_RS14225	COG2009	succinate dehydrogenase
HC658_RS14230	COG1719	4-vinyl reductase, 4VR
HC658_RS14235	COG0527	aspartate kinase activity
HC658_RS14240	COG0322	excinuclease ABC activity
HC658_RS14245	COG3118	belongs to the thioredoxin family
HC658_RS14250	COG3534	alpha-L-arabinofuranosidase
HC658_RS14255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HC658_RS14260	COG2086	electron transfer activity
HC658_RS14265	COG1024	Enoyl-CoA hydratase
HC658_RS14270	COG1309	transcriptional regulator
HC658_RS14275	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS14280	COG3766	membrane
HC658_RS14285	COG1193	negative regulation of DNA recombination
HC658_RS14290	COG1796	DNA polymerase
HC658_RS14290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC658_RS14295	COG1286	toxin biosynthetic process
HC658_RS14300	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HC658_RS14305	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC658_RS14310	COG0072	phenylalanine-tRNA ligase activity
HC658_RS14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_RS14315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC658_RS14325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC658_RS14335	COG3835	regulator
HC658_RS14340	COG0277	FAD linked oxidase domain protein
HC658_RS14345	COG0247	lactate metabolic process
HC658_RS14350	COG0346	lactoylglutathione lyase activity
HC658_RS14355	COG1966	Carbon starvation protein
HC658_RS14360	COG3534	alpha-L-arabinofuranosidase
HC658_RS14365	COG0395	ABC-type sugar transport system, permease component
HC658_RS14370	COG1175	transmembrane transport
HC658_RS14375	COG1653	transport
HC658_RS14380	COG0371	Dehydrogenase
HC658_RS14385	COG0647	UMP catabolic process
HC658_RS14390	COG0235	Class ii aldolase
HC658_RS14395	COG1069	ribulokinase activity
HC658_RS14400	COG2160	L-arabinose isomerase activity
HC658_RS14405	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_RS14410	COG1363	Peptidase, m42
HC658_RS14420	COG3326	Membrane
HC658_RS14425	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC658_RS14430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC658_RS14435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC658_RS14445	COG1346	cytolysis
HC658_RS14450	COG1380	Effector of murein hydrolase LrgA
HC658_RS14455	COG3279	Response regulator of the LytR AlgR family
HC658_RS14460	COG3275	phosphorelay sensor kinase activity
HC658_RS14465	COG1011	Hydrolase
HC658_RS14470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC658_RS14480	COG0398	Pfam SNARE associated Golgi protein
HC658_RS14485	COG1484	DNA-dependent DNA replication
HC658_RS14490	COG3611	Membrane attachment protein
HC658_RS14495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC658_RS14500	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HC658_RS14505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC658_RS14510	COG1733	regulation of RNA biosynthetic process
HC658_RS14515	COG2814	Major facilitator Superfamily
HC658_RS14520	COG0656	L-ascorbic acid biosynthetic process
HC658_RS14525	COG0237	dephospho-CoA kinase activity
HC658_RS14530	COG1971	Probably functions as a manganese efflux pump
HC658_RS14535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC658_RS14540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_RS14540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC658_RS14545	COG5002	protein histidine kinase activity
HC658_RS14550	COG0745	RESPONSE REGULATOR receiver
HC658_RS14555	COG0039	L-malate dehydrogenase activity
HC658_RS14560	COG0538	isocitrate dehydrogenase activity
HC658_RS14565	COG0372	Belongs to the citrate synthase family
HC658_RS14570	COG2707	UPF0756 membrane protein
HC658_RS14575	COG0628	permease
HC658_RS14580	COG3030	protein affecting phage T7 exclusion by the F plasmid
HC658_RS14585	COG0469	pyruvate kinase activity
HC658_RS14590	COG0205	6-phosphofructokinase activity
HC658_RS14595	COG0825	malonyl-CoA metabolic process
HC658_RS14600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC658_RS14605	COG0281	malic enzyme
HC658_RS14610	COG0587	DNA-directed DNA polymerase activity
HC658_RS14630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC658_RS14640	COG4109	DRTGG domain
HC658_RS14645	COG0730	response to heat
HC658_RS14650	COG1473	amidohydrolase
HC658_RS14655	COG0196	riboflavin kinase activity
HC658_RS14660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS14665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC658_RS14670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS14675	COG1126	abc transporter atp-binding protein
HC658_RS14680	COG0765	amino acid transport
HC658_RS14685	COG0765	amino acid transport
HC658_RS14690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS14695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS14700	COG0454	-acetyltransferase
HC658_RS14705	COG0583	DNA-binding transcription factor activity
HC658_RS14710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC658_RS14715	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS14720	COG0165	Argininosuccinate lyase
HC658_RS14725	COG0137	argininosuccinate synthase activity
HC658_RS14730	COG0521	Mo-molybdopterin cofactor biosynthetic process
HC658_RS14735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC658_RS14745	COG0827	DNA restriction-modification system
HC658_RS14750	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HC658_RS14755	COG3874	Sporulation protein YtfJ
HC658_RS14765	COG1714	RDD family
HC658_RS14770	COG0616	signal peptide processing
HC658_RS14775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC658_RS14780	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HC658_RS14785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC658_RS14795	COG0301	tRNA thio-modification
HC658_RS14800	COG1104	cysteine desulfurase activity
HC658_RS14805	COG1114	Component of the transport system for branched-chain amino acids
HC658_RS14810	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC658_RS14815	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HC658_RS14820	COG1309	transcriptional regulator
HC658_RS14825	COG1956	GAF domain-containing protein
HC658_RS14830	COG2203	Gaf domain
HC658_RS14830	COG2199	diguanylate cyclase activity
HC658_RS14840	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC658_RS14845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC658_RS14850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HC658_RS14855	COG0454	-acetyltransferase
HC658_RS14860	COG0517	IMP dehydrogenase activity
HC658_RS14865	COG0123	including yeast histone deacetylase and acetoin utilization protein
HC658_RS14870	COG1360	Flagellar Motor Protein
HC658_RS14875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HC658_RS14880	COG1609	Transcriptional regulator
HC658_RS14885	COG1605	Chorismate mutase
HC658_RS14885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC658_RS14890	COG3118	belongs to the thioredoxin family
HC658_RS14895	COG4980	gas vesicle protein
HC658_RS14900	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HC658_RS14905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC658_RS14910	COG1674	ftsk spoiiie
HC658_RS14915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC658_RS14920	COG4848	Belongs to the UPF0354 family
HC658_RS14925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS14940	COG1363	Peptidase, m42
HC658_RS14945	COG5584	Small secreted protein
HC658_RS14950	COG0281	malic enzyme
HC658_RS14955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS14960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC658_RS14970	COG0510	thiamine kinase activity
HC658_RS14975	COG1523	belongs to the glycosyl hydrolase 13 family
HC658_RS14980	COG1597	lipid kinase activity
HC658_RS14990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HC658_RS14995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC658_RS15000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_RS15005	COG2252	PERMEase
HC658_RS15010	COG4473	ABC transporter
HC658_RS15015	COG1131	(ABC) transporter
HC658_RS15020	COG1349	DNA-binding transcription factor activity
HC658_RS15025	COG1187	pseudouridine synthase activity
HC658_RS15030	COG2244	polysaccharide biosynthetic process
HC658_RS15035	COG2081	HI0933 family
HC658_RS15040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HC658_RS15050	COG5578	integral membrane protein
HC658_RS15055	COG0673	inositol 2-dehydrogenase activity
HC658_RS15060	COG1653	transport
HC658_RS15065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC658_RS15070	COG4209	transmembrane transport
HC658_RS15075	COG2207	Transcriptional regulator
HC658_RS15080	COG1653	transport
HC658_RS15085	COG0395	ABC-type sugar transport system, permease component
HC658_RS15090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_RS15095	COG2124	cytochrome p450
HC658_RS15100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HC658_RS15110	COG0156	8-amino-7-oxononanoate synthase activity
HC658_RS15115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HC658_RS15125	COG1073	alpha beta
HC658_RS15130	COG1609	Transcriptional regulator
HC658_RS15135	COG1653	transport
HC658_RS15140	COG1175	transmembrane transport
HC658_RS15145	COG0395	ABC-type sugar transport system, permease component
HC658_RS15150	COG1486	melibiose metabolic process
HC658_RS15155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC658_RS15160	COG0495	leucyl-tRNA aminoacylation
HC658_RS15170	COG1366	Belongs to the anti-sigma-factor antagonist family
HC658_RS15170	COG2202	Pas domain
HC658_RS15175	COG2814	Major facilitator Superfamily
HC658_RS15180	COG2433	Pfam Transposase IS66
HC658_RS15185	COG0577	efflux transmembrane transporter activity
HC658_RS15190	COG1136	(ABC) transporter
HC658_RS15195	COG2205	protein histidine kinase activity
HC658_RS15200	COG0745	RESPONSE REGULATOR receiver
HC658_RS15205	COG0577	efflux transmembrane transporter activity
HC658_RS15210	COG1136	(ABC) transporter
HC658_RS15225	COG1131	(ABC) transporter
HC658_RS15230	COG1725	Transcriptional regulator
HC658_RS15245	COG1242	4 iron, 4 sulfur cluster binding
HC658_RS15250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC658_RS15260	COG2267	carboxylic ester hydrolase activity
HC658_RS15265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC658_RS15270	COG1113	amino acid transport
HC658_RS15275	COG0367	asparagine synthase
HC658_RS15280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC658_RS15285	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HC658_RS15295	COG1506	peptidase
HC658_RS15300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HC658_RS15305	COG1116	anion transmembrane transporter activity
HC658_RS15310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC658_RS15315	COG0494	nUDIX hydrolase
HC658_RS15320	COG4824	toxin secretion phage lysis holin
HC658_RS15325	COG0783	Belongs to the Dps family
HC658_RS15340	COG1854	S-ribosylhomocysteine lyase activity
HC658_RS15345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HC658_RS15350	COG0288	reversible hydration of carbon dioxide
HC658_RS15355	COG0254	rRNA binding
HC658_RS15360	COG1271	oxidase subunit
HC658_RS15365	COG1294	oxidase, subunit
HC658_RS15375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_RS15380	COG1321	iron dependent repressor
HC658_RS15380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC658_RS15385	COG1121	(ABC) transporter
HC658_RS15390	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC658_RS15395	COG4948	Mandelate Racemase Muconate Lactonizing
HC658_RS15400	COG0318	PFAM AMP-dependent synthetase and ligase
HC658_RS15405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HC658_RS15410	COG0596	Alpha beta hydrolase
HC658_RS15415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HC658_RS15420	COG1169	isochorismate synthase
HC658_RS15425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HC658_RS15430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_RS15435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_RS15440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC658_RS15445	COG0438	transferase activity, transferring glycosyl groups
HC658_RS15455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_RS15460	COG0438	transferase activity, transferring glycosyl groups
HC658_RS15465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_RS15470	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC658_RS15475	COG0058	SHG alpha-glucan phosphorylase activity
HC658_RS15480	COG0297	glycogen (starch) synthase activity
HC658_RS15485	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC658_RS15490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HC658_RS15495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HC658_RS15620	COG3859	Proton-coupled thiamine transporter YuaJ
HC658_RS15625	COG1247	-acetyltransferase
HC658_RS15630	COG2268	Band 7 protein
HC658_RS15635	COG1585	Membrane protein implicated in regulation of membrane protease activity
HC658_RS15640	COG2318	DinB family
HC658_RS15650	COG1454	alcohol dehydrogenase
HC658_RS15655	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS15660	COG1510	regulation of RNA biosynthetic process
HC658_RS15670	COG0569	domain protein
HC658_RS15675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC658_RS15680	COG4682	membrane
HC658_RS15685	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC658_RS15690	COG0477	Major facilitator Superfamily
HC658_RS15695	COG5553	Cysteine dioxygenase type I
HC658_RS15705	COG1968	undecaprenyl-diphosphatase activity
HC658_RS15710	COG0628	permease
HC658_RS15715	COG0673	inositol 2-dehydrogenase activity
HC658_RS15720	COG4806	L-rhamnose isomerase
HC658_RS15725	COG3254	rhamnose metabolic process
HC658_RS15730	COG1070	Carbohydrate kinase
HC658_RS15735	COG1349	DNA-binding transcription factor activity
HC658_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS15740	COG3347	Dehydrogenase
HC658_RS15745	COG0840	transmembrane signaling receptor activity
HC658_RS15750	COG0840	transmembrane signaling receptor activity
HC658_RS15755	COG0840	transmembrane signaling receptor activity
HC658_RS15760	COG0840	transmembrane signaling receptor activity
HC658_RS15775	COG0432	Pfam Uncharacterised protein family UPF0047
HC658_RS15785	COG0366	Alpha amylase catalytic
HC658_RS15790	COG1253	flavin adenine dinucleotide binding
HC658_RS15795	COG2738	Putative neutral zinc metallopeptidase
HC658_RS15810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HC658_RS15825	COG0166	Belongs to the GPI family
HC658_RS15830	COG1979	alcohol dehydrogenase
HC658_RS15835	COG1979	alcohol dehydrogenase
HC658_RS15840	COG2155	Conserved Protein
HC658_RS15845	COG1098	S1 RNA binding domain
HC658_RS15850	COG0436	Aminotransferase
HC658_RS15855	COG1522	sequence-specific DNA binding
HC658_RS15860	COG2267	carboxylic ester hydrolase activity
HC658_RS15870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC658_RS15875	COG2205	protein histidine kinase activity
HC658_RS15885	COG5018	Exonuclease
HC658_RS15895	COG2814	Major facilitator Superfamily
HC658_RS15900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_RS15905	COG3011	Protein conserved in bacteria
HC658_RS15915	COG3290	protein histidine kinase activity
HC658_RS15920	COG4565	transcriptional regulatory protein
HC658_RS15945	COG3493	citrate carrier protein
HC658_RS15955	COG2111	Na H antiporter
HC658_RS15955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HC658_RS15960	COG2111	Na H antiporter
HC658_RS15965	COG1006	Multisubunit Na H antiporter MnhC subunit
HC658_RS15970	COG0651	ATP synthesis coupled electron transport
HC658_RS15975	COG1863	multisubunit Na H antiporter MnhE subunit
HC658_RS15980	COG2212	antiporter activity
HC658_RS15985	COG1320	monovalent cation:proton antiporter activity
HC658_RS15990	COG2050	protein possibly involved in aromatic compounds catabolism
HC658_RS16000	COG4585	Histidine kinase
HC658_RS16010	COG0142	geranyltranstransferase activity
HC658_RS16030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HC658_RS16035	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC658_RS16040	COG1335	isochorismatase
HC658_RS16045	COG5506	Protein of unknown function (DUF1694)
HC658_RS16060	COG0628	permease
HC658_RS16075	COG1418	mRNA catabolic process
HC658_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS16090	COG1511	domain protein
HC658_RS16095	COG1674	ftsk spoiiie
HC658_RS16095	COG0433	COG0433 Predicted ATPase
HC658_RS16100	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC658_RS16105	COG5417	Belongs to the EsaB family
HC658_RS16110	COG4842	Belongs to the WXG100 family
HC658_RS16115	COG2508	Transcriptional regulator
HC658_RS16115	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC658_RS16120	COG0686	Belongs to the AlaDH PNT family
HC658_RS16125	COG5634	Uncharacterized conserved protein (DUF2278)
HC658_RS16130	COG3251	PFAM MbtH domain protein
HC658_RS16135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS16140	COG3433	isochorismatase activity
HC658_RS16140	COG1535	isochorismatase
HC658_RS16145	COG1021	2,3-dihydroxybenzoate-AMP ligase
HC658_RS16150	COG1169	isochorismate synthase
HC658_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS16160	COG2819	hydrolase of the alpha beta superfamily
HC658_RS16165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HC658_RS16170	COG1268	BioY protein
HC658_RS16175	COG2056	Na+-H+ antiporter family
HC658_RS16180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HC658_RS16185	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HC658_RS16190	COG3584	3D domain protein
HC658_RS16205	COG1252	NADH dehydrogenase
HC658_RS16210	COG0492	ferredoxin-NADP+ reductase activity
HC658_RS16220	COG0516	GMP reductase activity
HC658_RS16225	COG2808	Putative FMN-binding domain
HC658_RS16230	COG0456	acetyltransferase
HC658_RS16235	COG0316	Belongs to the HesB IscA family
HC658_RS16240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC658_RS16245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_RS16250	COG4844	belongs to the
HC658_RS16255	COG1252	NADH dehydrogenase
HC658_RS16260	COG4837	Protein of unknown function (DUF1462)
HC658_RS16265	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HC658_RS16270	COG4946	Tricorn protease homolog
HC658_RS16270	COG0823	Involved in the tonB-independent uptake of proteins
HC658_RS16270	COG1506	peptidase
HC658_RS16275	COG0083	homoserine kinase activity
HC658_RS16280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HC658_RS16285	COG0460	homoserine dehydrogenase
HC658_RS16290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HC658_RS16295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC658_RS16300	COG0647	UMP catabolic process
HC658_RS16305	COG2445	Protein of unknown function DUF86
HC658_RS16310	COG4470	Protein conserved in bacteria
HC658_RS16320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HC658_RS16325	COG0739	heme binding
HC658_RS16335	COG3377	Domain of unknown function (DUF1805)
HC658_RS16340	COG0737	Belongs to the 5'-nucleotidase family
HC658_RS16345	COG0730	response to heat
HC658_RS16350	COG1801	Protein of unknown function DUF72
HC658_RS16360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC658_RS16365	COG2508	Transcriptional regulator
HC658_RS16370	COG2233	PERMEase
HC658_RS16375	COG2233	PERMEase
HC658_RS16380	COG3648	Uricase
HC658_RS16380	COG3195	allantoin biosynthetic process
HC658_RS16385	COG2351	hydroxyisourate hydrolase activity
HC658_RS16395	COG2080	2 iron, 2 sulfur cluster binding
HC658_RS16400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HC658_RS16405	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HC658_RS16410	COG2068	MobA-Related Protein
HC658_RS16415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HC658_RS16420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC658_RS16425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC658_RS16435	COG2356	endonuclease I
HC658_RS16440	COG3842	ATPase activity
HC658_RS16445	COG2188	Transcriptional regulator
HC658_RS16450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_RS16455	COG0395	ABC-type sugar transport system, permease component
HC658_RS16460	COG1175	transmembrane transport
HC658_RS16465	COG1653	transport
HC658_RS16470	COG2222	sugar isomerase
HC658_RS16475	COG0322	excinuclease ABC activity
HC658_RS16480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC658_RS16495	COG0346	lactoylglutathione lyase activity
HC658_RS16500	COG0640	Transcriptional regulator
HC658_RS16505	COG0719	Fe-S assembly protein
HC658_RS16510	COG0822	iron-sulfur transferase activity
HC658_RS16515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC658_RS16520	COG0719	Fe-S assembly protein
HC658_RS16525	COG0396	ATPase activity
HC658_RS16535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC658_RS16540	COG1464	Belongs to the NlpA lipoprotein family
HC658_RS16545	COG2011	ABC-type metal ion transport system permease component
HC658_RS16550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC658_RS16560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC658_RS16565	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC658_RS16575	COG0509	glycine decarboxylation via glycine cleavage system
HC658_RS16580	COG1393	Belongs to the ArsC family
HC658_RS16585	COG1960	acyl-CoA dehydrogenase activity
HC658_RS16590	COG0183	Belongs to the thiolase family
HC658_RS16595	COG1024	Enoyl-CoA hydratase
HC658_RS16595	COG1250	3-hydroxyacyl-CoA dehydrogenase
HC658_RS16605	COG0506	proline dehydrogenase activity
HC658_RS16615	COG5577	PFAM Coat F domain
HC658_RS16620	COG1846	Transcriptional regulator
HC658_RS16625	COG0477	Major facilitator Superfamily
HC658_RS16630	COG1942	4-Oxalocrotonate Tautomerase
HC658_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS16640	COG0583	DNA-binding transcription factor activity
HC658_RS16650	COG1120	ATPase activity
HC658_RS16665	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS16670	COG0783	Belongs to the Dps family
HC658_RS16675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_RS16680	COG0745	RESPONSE REGULATOR receiver
HC658_RS16685	COG2770	Histidine kinase
HC658_RS16685	COG2205	protein histidine kinase activity
HC658_RS16695	COG1309	transcriptional regulator
HC658_RS16700	COG0114	fumarate hydratase activity
HC658_RS16710	COG0697	spore germination
HC658_RS16715	COG0814	amino acid
HC658_RS16725	COG2197	response regulator
HC658_RS16730	COG4585	Histidine kinase
HC658_RS16735	COG4758	membrane
HC658_RS16740	COG3595	metallopeptidase activity
HC658_RS16745	COG1842	Phage shock protein A
HC658_RS16750	COG4758	membrane
HC658_RS16755	COG2814	Major facilitator Superfamily
HC658_RS16760	COG2096	Adenosyltransferase
HC658_RS16765	COG1120	ATPase activity
HC658_RS16770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS16775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS16780	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS16785	COG3386	PFAM SMP-30 Gluconolaconase
HC658_RS16790	COG2205	protein histidine kinase activity
HC658_RS16795	COG0745	RESPONSE REGULATOR receiver
HC658_RS16805	COG1191	sigma factor activity
HC658_RS16815	COG2140	Oxalate decarboxylase
HC658_RS16825	COG0577	efflux transmembrane transporter activity
HC658_RS16830	COG1136	(ABC) transporter
HC658_RS16835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HC658_RS16840	COG1120	ATPase activity
HC658_RS16845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC658_RS16855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS16860	COG0531	amino acid
HC658_RS16870	COG1988	membrane-bound metal-dependent
HC658_RS16875	COG1368	sulfuric ester hydrolase activity
HC658_RS16880	COG1910	domain protein
HC658_RS16885	COG0725	ABC transporter, periplasmic molybdate-binding protein
HC658_RS16890	COG4149	molybdate abc transporter
HC658_RS16895	COG0656	L-ascorbic acid biosynthetic process
HC658_RS16905	COG0025	NhaP-type Na H and K H
HC658_RS16910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HC658_RS16915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HC658_RS16920	COG3973	AAA domain
HC658_RS16930	COG2860	membrane
HC658_RS16935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HC658_RS16940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HC658_RS16945	COG2217	Heavy metal translocating P-type atpase
HC658_RS16950	COG2217	Heavy metal translocating P-type atpase
HC658_RS16955	COG2608	mercury ion transmembrane transporter activity
HC658_RS16960	COG1937	Protein conserved in bacteria
HC658_RS16965	COG0673	inositol 2-dehydrogenase activity
HC658_RS16970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC658_RS16975	COG1289	transmembrane transporter activity
HC658_RS16985	COG2076	Multidrug Resistance protein
HC658_RS16990	COG1309	transcriptional regulator
HC658_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS17005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC658_RS17010	COG0557	exoribonuclease II activity
HC658_RS17015	COG1647	Serine aminopeptidase, S33
HC658_RS17020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC658_RS17025	COG0596	Alpha beta hydrolase
HC658_RS17030	COG1476	TRANSCRIPTIONal
HC658_RS17035	COG1396	sequence-specific DNA binding
HC658_RS17040	COG1396	sequence-specific DNA binding
HC658_RS17045	COG1733	regulation of RNA biosynthetic process
HC658_RS17050	COG0840	transmembrane signaling receptor activity
HC658_RS17055	COG1174	glycine betaine transport
HC658_RS17060	COG1732	Glycine betaine
HC658_RS17065	COG1174	glycine betaine transport
HC658_RS17070	COG1125	glycine betaine transport
HC658_RS17070	COG0517	IMP dehydrogenase activity
HC658_RS17075	COG1510	regulation of RNA biosynthetic process
HC658_RS17095	COG5658	integral membrane protein
HC658_RS17100	COG0640	Transcriptional regulator
HC658_RS17105	COG1174	glycine betaine transport
HC658_RS17110	COG1732	Glycine betaine
HC658_RS17115	COG1174	glycine betaine transport
HC658_RS17120	COG1125	glycine betaine transport
HC658_RS17120	COG0517	IMP dehydrogenase activity
HC658_RS17125	COG1510	regulation of RNA biosynthetic process
HC658_RS17130	COG2095	MarC family integral membrane protein
HC658_RS17140	COG3064	Membrane
HC658_RS17145	COG4640	response to antibiotic
HC658_RS17150	COG0456	acetyltransferase
HC658_RS17155	COG0148	phosphopyruvate hydratase activity
HC658_RS17160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HC658_RS17165	COG0149	triose-phosphate isomerase activity
HC658_RS17170	COG0126	phosphoglycerate kinase activity
HC658_RS17175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HC658_RS17180	COG2390	Transcriptional regulator
HC658_RS17185	COG2814	Major facilitator Superfamily
HC658_RS17190	COG1609	Transcriptional regulator
HC658_RS17195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS17200	COG0583	DNA-binding transcription factor activity
HC658_RS17205	COG0697	spore germination
HC658_RS17210	COG1113	amino acid transport
HC658_RS17215	COG3858	chitin binding
HC658_RS17220	COG1556	Lactate utilization protein
HC658_RS17225	COG1139	Iron-sulfur cluster binding protein
HC658_RS17230	COG0247	lactate metabolic process
HC658_RS17235	COG2197	response regulator
HC658_RS17240	COG4585	Histidine kinase
HC658_RS17245	COG0842	Transport permease protein
HC658_RS17250	COG1131	(ABC) transporter
HC658_RS17255	COG0596	Alpha beta hydrolase
HC658_RS17260	COG2208	phosphoserine phosphatase activity
HC658_RS17265	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HC658_RS17270	COG1874	Beta-galactosidase
HC658_RS17275	COG3833	ABC-type maltose transport systems, permease component
HC658_RS17280	COG1175	transmembrane transport
HC658_RS17285	COG2182	Extracellular solute-binding protein
HC658_RS17290	COG1609	Transcriptional regulator
HC658_RS17295	COG2186	Transcriptional regulator
HC658_RS17300	COG1620	l-lactate permease
HC658_RS17305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC658_RS17315	COG5039	Polysaccharide pyruvyl transferase
HC658_RS17320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_RS17325	COG0110	maltose O-acetyltransferase activity
HC658_RS17330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC658_RS17335	COG2244	polysaccharide biosynthetic process
HC658_RS17340	COG1216	Glycosyl transferase, family 2
HC658_RS17345	COG5039	Polysaccharide pyruvyl transferase
HC658_RS17350	COG1216	Glycosyl transferase, family 2
HC658_RS17360	COG0438	transferase activity, transferring glycosyl groups
HC658_RS17365	COG1215	transferase activity, transferring glycosyl groups
HC658_RS17370	COG0438	transferase activity, transferring glycosyl groups
HC658_RS17375	COG1086	Polysaccharide biosynthesis protein
HC658_RS17380	COG0489	protein tyrosine kinase activity
HC658_RS17385	COG3944	biosynthesis protein
HC658_RS17390	COG1396	sequence-specific DNA binding
HC658_RS17395	COG2272	Belongs to the type-B carboxylesterase lipase family
HC658_RS17405	COG3479	Phenolic acid decarboxylase
HC658_RS17415	COG1794	racemase activity, acting on amino acids and derivatives
HC658_RS17420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HC658_RS17425	COG1621	beta-fructofuranosidase activity
HC658_RS17430	COG1621	beta-fructofuranosidase activity
HC658_RS17435	COG0531	amino acid
HC658_RS17440	COG1309	transcriptional regulator
HC658_RS17445	COG2076	Multidrug Resistance protein
HC658_RS17450	COG2076	Multidrug Resistance protein
HC658_RS17460	COG0277	FAD linked oxidase domain protein
HC658_RS17465	COG3621	Patatin-like phospholipase
HC658_RS17475	COG0740	serine-type endopeptidase activity
HC658_RS17480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC658_RS17485	COG0366	Alpha amylase catalytic
HC658_RS17490	COG1554	hydrolase, family 65, central catalytic
HC658_RS17495	COG5521	maltodextrose utilization protein MalA
HC658_RS17500	COG3833	ABC-type maltose transport systems, permease component
HC658_RS17505	COG1175	transmembrane transport
HC658_RS17510	COG2182	Extracellular solute-binding protein
HC658_RS17515	COG0366	Alpha amylase catalytic
HC658_RS17520	COG1609	Transcriptional regulator
HC658_RS17525	COG1611	Belongs to the LOG family
HC658_RS17530	COG1694	Mazg nucleotide pyrophosphohydrolase
HC658_RS17535	COG0659	secondary active sulfate transmembrane transporter activity
HC658_RS17540	COG0288	reversible hydration of carbon dioxide
HC658_RS17545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC658_RS17550	COG0577	efflux transmembrane transporter activity
HC658_RS17555	COG1136	(ABC) transporter
HC658_RS17560	COG5002	protein histidine kinase activity
HC658_RS17565	COG0745	RESPONSE REGULATOR receiver
HC658_RS17575	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HC658_RS17580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS17585	COG1481	regulation of sporulation
HC658_RS17590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC658_RS17595	COG1660	Displays ATPase and GTPase activities
HC658_RS17600	COG1051	belongs to the nudix hydrolase family
HC658_RS17605	COG0492	ferredoxin-NADP+ reductase activity
HC658_RS17610	COG0791	NLP P60 protein
HC658_RS17610	COG3883	PFAM NLP P60 protein
HC658_RS17615	COG0457	Tetratricopeptide repeat
HC658_RS17620	COG1132	(ABC) transporter
HC658_RS17640	COG0140	phosphoribosyl-ATP diphosphatase activity
HC658_RS17640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HC658_RS17645	COG0107	imidazoleglycerol-phosphate synthase activity
HC658_RS17650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HC658_RS17655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HC658_RS17660	COG0131	Imidazoleglycerol-phosphate dehydratase
HC658_RS17665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HC658_RS17670	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HC658_RS17675	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HC658_RS17680	COG4990	cell redox homeostasis
HC658_RS17685	COG5297	Belongs to the glycosyl hydrolase family 6
HC658_RS17690	COG0110	maltose O-acetyltransferase activity
HC658_RS17695	COG0546	phosphoglycolate phosphatase activity
HC658_RS17700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HC658_RS17705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC658_RS17710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC658_RS17715	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC658_RS17720	COG0363	glucosamine-6-phosphate deaminase activity
HC658_RS17725	COG2188	Transcriptional regulator
HC658_RS17730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HC658_RS17735	COG1846	Transcriptional regulator
HC658_RS17740	COG2124	cytochrome p450
HC658_RS17750	COG1846	Transcriptional regulator
HC658_RS17755	COG2814	Major facilitator Superfamily
HC658_RS17760	COG1950	PFAM Membrane protein of
HC658_RS17765	COG1983	PspC domain protein
HC658_RS17770	COG3595	metallopeptidase activity
HC658_RS17790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC658_RS17795	COG0556	nucleotide-excision repair
HC658_RS17800	COG4897	Protein conserved in bacteria
HC658_RS17805	COG0574	Belongs to the PEP-utilizing enzyme family
HC658_RS17805	COG3848	Pyruvate phosphate dikinase
HC658_RS17810	COG1309	transcriptional regulator
HC658_RS17815	COG2814	Major facilitator Superfamily
HC658_RS17820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_RS17830	COG0793	Belongs to the peptidase S41A family
HC658_RS17830	COG3409	Peptidoglycan-binding domain 1 protein
HC658_RS17835	COG2177	Part of the ABC transporter FtsEX involved in
HC658_RS17840	COG2884	Cell division ATP-binding protein ftsE
HC658_RS17845	COG2010	Cytochrome c
HC658_RS17850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS17860	COG0653	protein targeting
HC658_RS17865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HC658_RS17880	COG1516	flagellar protein fliS
HC658_RS17885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HC658_RS17890	COG1334	flagellar protein FlaG
HC658_RS17895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC658_RS17900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HC658_RS17905	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HC658_RS17915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HC658_RS17920	COG1256	bacterial-type flagellum assembly
HC658_RS17920	COG4786	Flagellar basal body rod
HC658_RS17925	COG3418	PFAM FlgN family protein
HC658_RS17930	COG2747	anti-sigma28 factor FlgM
HC658_RS17940	COG1040	competence protein
HC658_RS17950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC658_RS17955	COG1307	EDD domain protein, DegV family
HC658_RS17960	COG2197	response regulator
HC658_RS17965	COG4585	Histidine kinase
HC658_RS17970	COG1739	Uncharacterized protein family UPF0029
HC658_RS17975	COG1316	TRANSCRIPTIONal
HC658_RS17980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC658_RS17985	COG0438	transferase activity, transferring glycosyl groups
HC658_RS17990	COG1215	transferase activity, transferring glycosyl groups
HC658_RS17995	COG3206	protein involved in exopolysaccharide biosynthesis
HC658_RS18000	COG3307	-O-antigen
HC658_RS18005	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_RS18010	COG0297	glycogen (starch) synthase activity
HC658_RS18010	COG0438	transferase activity, transferring glycosyl groups
HC658_RS18015	COG2244	polysaccharide biosynthetic process
HC658_RS18025	COG2247	cell wall binding repeat
HC658_RS18025	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC658_RS18030	COG2385	sporulation resulting in formation of a cellular spore
HC658_RS18030	COG2247	cell wall binding repeat
HC658_RS18040	COG1316	TRANSCRIPTIONal
HC658_RS18045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HC658_RS18050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_RS18060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_RS18060	COG1215	transferase activity, transferring glycosyl groups
HC658_RS18065	COG0463	Glycosyl transferase, family 2
HC658_RS18075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_RS18085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC658_RS18090	COG1134	teichoic acid transport
HC658_RS18095	COG1682	transport, permease protein
HC658_RS18100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_RS18105	COG0438	transferase activity, transferring glycosyl groups
HC658_RS18110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HC658_RS18115	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HC658_RS18120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_RS18130	COG4193	domain, Protein
HC658_RS18135	COG1482	cell wall glycoprotein biosynthetic process
HC658_RS18140	COG0697	spore germination
HC658_RS18145	COG0814	amino acid
HC658_RS18155	COG2814	Major facilitator Superfamily
HC658_RS18160	COG1316	TRANSCRIPTIONal
HC658_RS18165	COG0561	phosphatase activity
HC658_RS18170	COG0791	NLP P60 protein
HC658_RS18180	COG2843	Capsule synthesis protein
HC658_RS18190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HC658_RS18195	COG1609	Transcriptional regulator
HC658_RS18200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_RS18205	COG1869	D-ribose catabolic process
HC658_RS18210	COG1129	ABC transporter
HC658_RS18215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HC658_RS18220	COG1879	ABC-type sugar transport system periplasmic component
HC658_RS18225	COG3103	Sh3 type 3 domain protein
HC658_RS18235	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC658_RS18240	COG3527	Alpha-acetolactate decarboxylase
HC658_RS18245	COG0028	Belongs to the TPP enzyme family
HC658_RS18250	COG0583	DNA-binding transcription factor activity
HC658_RS18255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HC658_RS18270	COG5337	Spore coat protein CotH
HC658_RS18280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC658_RS18290	COG0405	Gamma-glutamyltransferase
HC658_RS18295	COG1522	sequence-specific DNA binding
HC658_RS18300	COG2059	Chromate
HC658_RS18305	COG2059	Chromate
HC658_RS18315	COG0655	NAD(P)H dehydrogenase (quinone) activity
HC658_RS18320	COG0583	DNA-binding transcription factor activity
HC658_RS18335	COG5444	nuclease activity
HC658_RS18355	COG3878	Protein conserved in bacteria
HC658_RS18360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HC658_RS18365	COG4464	protein tyrosine phosphatase activity
HC658_RS18370	COG0489	protein tyrosine kinase activity
HC658_RS18375	COG3944	biosynthesis protein
HC658_RS18385	COG4715	Zinc finger, swim domain protein
HC658_RS18390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HC658_RS18395	COG0561	phosphatase activity
HC658_RS18400	COG1349	DNA-binding transcription factor activity
HC658_RS18405	COG0629	single-stranded DNA binding
HC658_RS18420	COG3764	Sortase (surface protein transpeptidase)
HC658_RS18430	COG2972	Histidine kinase
HC658_RS18430	COG0745	RESPONSE REGULATOR receiver
HC658_RS18435	COG1970	mechanosensitive ion channel activity
HC658_RS18440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC658_RS18445	COG0457	Tetratricopeptide repeat
HC658_RS18450	COG4786	Flagellar basal body rod
HC658_RS18455	COG4786	Flagellar basal body rod
HC658_RS18460	COG1077	Cell shape determining protein MreB Mrl
HC658_RS18465	COG1609	Transcriptional regulator
HC658_RS18475	COG1846	Transcriptional regulator
HC658_RS18480	COG2814	Major facilitator Superfamily
HC658_RS18485	COG3420	alginic acid biosynthetic process
HC658_RS18490	COG1953	Uracil, thiamine, allantoin
HC658_RS18495	COG0477	Major facilitator Superfamily
HC658_RS18500	COG1335	isochorismatase
HC658_RS18510	COG0004	ammonium transporteR
HC658_RS18515	COG0347	Belongs to the P(II) protein family
HC658_RS18520	COG0671	phosphoesterase, PA-phosphatase related
HC658_RS18530	COG0739	heme binding
HC658_RS18535	COG1247	-acetyltransferase
HC658_RS18555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_RS18560	COG0789	Transcriptional regulator
HC658_RS18570	COG2910	NAD(P)H-binding
HC658_RS18575	COG1959	2 iron, 2 sulfur cluster binding
HC658_RS18580	COG0804	urea catabolic process
HC658_RS18585	COG0832	Belongs to the urease beta subunit family
HC658_RS18590	COG0831	urea catabolic process
HC658_RS18605	COG3237	CsbD-like
HC658_RS18610	COG1994	Peptidase M50
HC658_RS18615	COG0457	Tetratricopeptide repeat
HC658_RS18620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HC658_RS18625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HC658_RS18635	COG2304	oxidoreductase activity
HC658_RS18645	COG2304	oxidoreductase activity
HC658_RS18650	COG2385	sporulation resulting in formation of a cellular spore
HC658_RS18655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC658_RS18665	COG4836	Membrane
HC658_RS18675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC658_RS18680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC658_RS18685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC658_RS18690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC658_RS18695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC658_RS18700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC658_RS18710	COG0356	it plays a direct role in the translocation of protons across the membrane
HC658_RS18720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC658_RS18725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC658_RS18730	COG4475	Protein of unknown function (DUF436)
HC658_RS18735	COG0698	ribose 5-phosphate isomerase
HC658_RS18740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC658_RS18745	COG1971	Probably functions as a manganese efflux pump
HC658_RS18750	COG0009	L-threonylcarbamoyladenylate synthase
HC658_RS18755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HC658_RS18775	COG2890	protein-(glutamine-N5) methyltransferase activity
HC658_RS18780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC658_RS18785	COG0346	lactoylglutathione lyase activity
HC658_RS18790	COG0789	Transcriptional regulator
HC658_RS18795	COG0679	Auxin Efflux Carrier
HC658_RS18800	COG0281	malic enzyme
HC658_RS18805	COG1435	thymidine kinase activity
HC658_RS18815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC658_RS18825	COG1494	fructose-1,6-bisphosphatase
HC658_RS18830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC658_RS18835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HC658_RS18840	COG0191	fructose-bisphosphate aldolase activity
HC658_RS18845	COG2204	response regulator
HC658_RS18850	COG4821	SIS domain
HC658_RS18855	COG0504	CTP synthase activity
HC658_RS18860	COG3343	RNA polymerase activity
HC658_RS18865	COG1960	acyl-CoA dehydrogenase activity
HC658_RS18870	COG0247	lactate metabolic process
HC658_RS18870	COG2181	nitrate reductase activity
HC658_RS18875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_RS18880	COG4294	response to UV
HC658_RS18890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_RS18895	COG1132	(ABC) transporter
HC658_RS18900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC658_RS18910	COG2181	nitrate reductase activity
HC658_RS18915	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HC658_RS18920	COG1140	nitrate reductase beta subunit
HC658_RS18925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HC658_RS18930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC658_RS18940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC658_RS18945	COG2223	nitrite transmembrane transporter activity
HC658_RS18950	COG0018	arginyl-trna synthetase
HC658_RS18955	COG4506	Protein conserved in bacteria
HC658_RS18970	COG0535	radical SAM domain protein
HC658_RS18980	COG1131	(ABC) transporter
HC658_RS18985	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC658_RS18990	COG0612	Peptidase, M16
HC658_RS18995	COG0612	Peptidase, M16
HC658_RS19005	COG3391	amine dehydrogenase activity
HC658_RS19010	COG3391	amine dehydrogenase activity
HC658_RS19020	COG0457	Tetratricopeptide repeat
HC658_RS19035	COG0010	Belongs to the arginase family
HC658_RS19040	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HC658_RS19045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC658_RS19055	COG1994	Peptidase M50
HC658_RS19060	COG1942	4-Oxalocrotonate Tautomerase
HC658_RS19065	COG1846	Transcriptional regulator
HC658_RS19070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC658_RS19075	COG0477	Major facilitator Superfamily
HC658_RS19080	COG1959	2 iron, 2 sulfur cluster binding
HC658_RS19085	COG3465	dGTPase activity
HC658_RS19090	COG1078	dGTPase activity
HC658_RS19095	COG4844	belongs to the
HC658_RS19105	COG0697	spore germination
HC658_RS19110	COG0095	Lipoate-protein ligase
HC658_RS19115	COG0583	DNA-binding transcription factor activity
HC658_RS19120	COG0280	phosphate acetyltransferase
HC658_RS19130	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS19135	COG0436	Aminotransferase
HC658_RS19140	COG2814	Major facilitator Superfamily
HC658_RS19145	COG0151	Belongs to the GarS family
HC658_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS19155	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS19160	COG0077	Prephenate dehydratase
HC658_RS19165	COG2814	Major facilitator Superfamily
HC658_RS19170	COG0833	amino acid
HC658_RS19175	COG4187	Peptidase family M20/M25/M40
HC658_RS19180	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS19185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC658_RS19195	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC658_RS19200	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC658_RS19205	COG1088	dTDP-glucose 4,6-dehydratase activity
HC658_RS19210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC658_RS19215	COG3980	spore coat polysaccharide biosynthesis protein
HC658_RS19220	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HC658_RS19225	COG2089	acid synthase
HC658_RS19230	COG0456	acetyltransferase
HC658_RS19235	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HC658_RS19240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HC658_RS19245	COG0463	Glycosyl transferase, family 2
HC658_RS19255	COG2363	Small membrane protein
HC658_RS19260	COG2233	PERMEase
HC658_RS19270	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS19275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC658_RS19280	COG1216	Glycosyl transferase, family 2
HC658_RS19285	COG0351	phosphomethylpyrimidine kinase
HC658_RS19295	COG1621	beta-fructofuranosidase activity
HC658_RS19300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS19300	COG1263	PTS System
HC658_RS19305	COG2116	formate transmembrane transporter activity
HC658_RS19310	COG3711	transcriptional antiterminator
HC658_RS19320	COG1404	Belongs to the peptidase S8 family
HC658_RS19325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS19330	COG0778	Nitroreductase
HC658_RS19335	COG0772	Belongs to the SEDS family
HC658_RS19345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HC658_RS19350	COG1845	cytochrome c oxidase, subunit III
HC658_RS19355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HC658_RS19360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HC658_RS19365	COG2261	transglycosylase associated protein
HC658_RS19370	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC658_RS19375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC658_RS19380	COG2246	polysaccharide biosynthetic process
HC658_RS19385	COG1309	transcriptional regulator
HC658_RS19395	COG3162	membrane
HC658_RS19400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HC658_RS19405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HC658_RS19410	COG2837	iron assimilation
HC658_RS19415	COG2822	iron ion transport
HC658_RS19420	COG0672	)-iron permease
HC658_RS19425	COG0352	thiamine-phosphate diphosphorylase activity
HC658_RS19430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HC658_RS19435	COG0583	DNA-binding transcription factor activity
HC658_RS19440	COG1380	Effector of murein hydrolase LrgA
HC658_RS19445	COG1346	cytolysis
HC658_RS19450	COG2814	Major facilitator Superfamily
HC658_RS19455	COG4895	conserved protein (DUF2196)
HC658_RS19460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC658_RS19465	COG0346	lactoylglutathione lyase activity
HC658_RS19480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_RS19490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS19490	COG1263	PTS System
HC658_RS19495	COG3711	transcriptional antiterminator
HC658_RS19500	COG1442	glycosyl transferase family 8
HC658_RS19505	COG5522	Integral membrane protein (intg_mem_TP0381)
HC658_RS19510	COG1846	Transcriptional regulator
HC658_RS19515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HC658_RS19520	COG2234	aminopeptidase activity
HC658_RS19535	COG2814	Major facilitator Superfamily
HC658_RS19540	COG2357	RelA SpoT domain protein
HC658_RS19545	COG1575	Belongs to the MenA family. Type 1 subfamily
HC658_RS19560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC658_RS19565	COG1696	Membrane protein involved in D-alanine export
HC658_RS19570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC658_RS19575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC658_RS19580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HC658_RS19585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC658_RS19590	COG1486	melibiose metabolic process
HC658_RS19595	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC658_RS19600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_RS19605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC658_RS19610	COG3711	transcriptional antiterminator
HC658_RS19610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC658_RS19620	COG2094	Belongs to the DNA glycosylase MPG family
HC658_RS19625	COG0753	catalase activity
HC658_RS19630	COG2814	Major facilitator Superfamily
HC658_RS19635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC658_RS19640	COG1131	(ABC) transporter
HC658_RS19660	COG1595	DNA-templated transcription, initiation
HC658_RS19665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HC658_RS19670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC658_RS19675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HC658_RS19680	COG4988	ABC transporter
HC658_RS19685	COG1294	oxidase, subunit
HC658_RS19690	COG1271	oxidase subunit
HC658_RS19695	COG3493	citrate carrier protein
HC658_RS19700	COG0501	Belongs to the peptidase M48B family
HC658_RS19710	COG0726	polysaccharide deacetylase
HC658_RS19715	COG3842	ATPase activity
HC658_RS19720	COG2508	Transcriptional regulator
HC658_RS19730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC658_RS19740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC658_RS19750	COG4585	Histidine kinase
HC658_RS19755	COG2197	response regulator
HC658_RS19760	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC658_RS19770	COG4894	glucomannan catabolic process
HC658_RS19775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_RS19780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC658_RS19785	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS19790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HC658_RS19795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HC658_RS19800	COG2610	gluconate transmembrane transporter activity
HC658_RS19805	COG0500	methyltransferase
HC658_RS19810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_RS19825	COG0693	protein deglycase activity
HC658_RS19825	COG0753	catalase activity
HC658_RS19830	COG2851	Citrate transporter
HC658_RS19835	COG2273	Hydrolase Family 16
HC658_RS19840	COG3711	transcriptional antiterminator
HC658_RS19850	COG2270	Major facilitator Superfamily
HC658_RS19855	COG0513	Belongs to the DEAD box helicase family
HC658_RS19860	COG3401	FG-GAP repeat protein
HC658_RS19860	COG2755	lipolytic protein G-D-S-L family
HC658_RS19920	COG3209	COG3209 Rhs family protein
HC658_RS19925	COG0697	spore germination
HC658_RS19930	COG0589	response to stress
HC658_RS19935	COG2723	6-phospho-beta-galactosidase activity
HC658_RS19940	COG2190	(PTS) system
HC658_RS19940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC658_RS19940	COG1263	PTS System
HC658_RS19990	COG3507	Belongs to the glycosyl hydrolase 43 family
HC658_RS20005	COG2986	histidine ammonia-lyase
HC658_RS20010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HC658_RS20015	COG1228	amidohydrolase
HC658_RS20020	COG0010	Belongs to the arginase family
HC658_RS20025	COG0833	amino acid
HC658_RS20030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC658_RS20035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC658_RS20040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC658_RS20045	COG2390	Transcriptional regulator
HC658_RS20055	COG3192	ethanolamine utilization protein
HC658_RS20060	COG2079	MmgE PrpD family protein
HC658_RS20065	COG1473	amidohydrolase
HC658_RS20070	COG1126	abc transporter atp-binding protein
HC658_RS20075	COG0765	amino acid transport
HC658_RS20080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC658_RS20085	COG0456	acetyltransferase
HC658_RS20090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC658_RS20095	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC658_RS20100	COG0561	phosphatase activity
HC658_RS20130	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HC658_RS20135	COG5294	Protein conserved in bacteria
HC658_RS20140	COG0577	efflux transmembrane transporter activity
HC658_RS20145	COG1136	(ABC) transporter
HC658_RS20150	COG2205	protein histidine kinase activity
HC658_RS20155	COG0745	RESPONSE REGULATOR receiver
HC658_RS20160	COG0191	fructose-bisphosphate aldolase activity
HC658_RS20165	COG1082	Xylose isomerase domain protein TIM barrel
HC658_RS20170	COG1082	Xylose isomerase domain protein TIM barrel
HC658_RS20175	COG0673	inositol 2-dehydrogenase activity
HC658_RS20180	COG2814	Major facilitator Superfamily
HC658_RS20185	COG1082	Xylose isomerase domain protein TIM barrel
HC658_RS20190	COG3962	Belongs to the TPP enzyme family
HC658_RS20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HC658_RS20200	COG3718	enzyme involved in inositol metabolism
HC658_RS20205	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS20210	COG1349	DNA-binding transcription factor activity
HC658_RS20215	COG0667	Aldo Keto reductase
HC658_RS20230	COG2814	Major facilitator Superfamily
HC658_RS20235	COG0326	Molecular chaperone. Has ATPase activity
HC658_RS20245	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS20250	COG1309	transcriptional regulator
HC658_RS20255	COG1012	belongs to the aldehyde dehydrogenase family
HC658_RS20265	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HC658_RS20275	COG1714	RDD family
HC658_RS20280	COG2311	Membrane
HC658_RS20285	COG1917	Cupin 2, conserved barrel domain protein
HC658_RS20290	COG1309	transcriptional regulator
HC658_RS20295	COG1028	Short-chain dehydrogenase reductase Sdr
HC658_RS20300	COG1846	Transcriptional regulator
HC658_RS20305	COG1380	Effector of murein hydrolase LrgA
HC658_RS20310	COG1346	cytolysis
HC658_RS20315	COG5039	Polysaccharide pyruvyl transferase
HC658_RS20320	COG1929	Belongs to the glycerate kinase type-1 family
HC658_RS20325	COG1802	Transcriptional regulator
HC658_RS20330	COG1070	Carbohydrate kinase
HC658_RS20335	COG2610	gluconate transmembrane transporter activity
HC658_RS20340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC658_RS20345	COG0450	alkyl hydroperoxide reductase
HC658_RS20350	COG3634	alkyl hydroperoxide reductase activity
HC658_RS20355	COG2723	6-phospho-beta-galactosidase activity
HC658_RS20365	COG2188	Transcriptional regulator
HC658_RS20375	COG1131	(ABC) transporter
HC658_RS20380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC658_RS20390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC658_RS20405	COG1063	alcohol dehydrogenase
HC658_RS20425	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HC658_RS20430	COG0456	acetyltransferase
HC658_RS20435	COG0457	Tetratricopeptide repeat
HC658_RS20445	COG0010	Belongs to the arginase family
HC658_RS20450	COG0833	amino acid
HC658_RS20455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HC658_RS20460	COG3829	transcription factor binding
HC658_RS20465	COG5002	protein histidine kinase activity
HC658_RS20490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC658_RS20495	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC658_RS20500	COG4853	Protein conserved in bacteria
HC658_RS20505	COG4863	YycH protein
HC658_RS20510	COG5002	protein histidine kinase activity
HC658_RS20515	COG0745	RESPONSE REGULATOR receiver
HC658_RS20545	COG0346	lactoylglutathione lyase activity
HC658_RS20550	COG0305	Participates in initiation and elongation during chromosome replication
HC658_RS20565	COG3093	addiction module antidote protein HigA
HC658_RS20570	COG2807	transmembrane transport
HC658_RS20575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HC658_RS20580	COG0359	binds to the 23S rRNA
HC658_RS20585	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HC658_RS20590	COG4241	membrane
HC658_RS20600	COG5577	PFAM Coat F domain
HC658_RS20605	COG1733	regulation of RNA biosynthetic process
HC658_RS20610	COG1227	inorganic diphosphatase activity
HC658_RS20620	COG2271	Major facilitator Superfamily
HC658_RS20660	COG1131	(ABC) transporter
HC658_RS20675	COG4319	ketosteroid isomerase
HC658_RS20680	COG1357	PFAM Pentapeptide repeats (8 copies)
HC658_RS20685	COG2814	Major facilitator Superfamily
HC658_RS20690	COG0583	DNA-binding transcription factor activity
HC658_RS20695	COG2153	protein acetylation
HC658_RS20710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HC658_RS20715	COG1846	Transcriptional regulator
HC658_RS20720	COG2153	protein acetylation
HC658_RS20725	COG2364	Membrane
HC658_RS20730	COG0456	acetyltransferase
HC658_RS20735	COG2315	Protein conserved in bacteria
HC658_RS20740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC658_RS20750	COG2814	Major facilitator Superfamily
HC658_RS20760	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_RS20775	COG0789	Transcriptional regulator
HC658_RS20780	COG0697	spore germination
HC658_RS20790	COG1280	lysine exporter protein (LysE YggA)
HC658_RS20795	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_RS20800	COG1331	Highly conserved protein containing a thioredoxin domain
HC658_RS20805	COG1266	CAAX protease self-immunity
HC658_RS20810	COG0477	Major facilitator Superfamily
HC658_RS20810	COG2814	Major facilitator Superfamily
HC658_RS20815	COG0110	maltose O-acetyltransferase activity
HC658_RS20820	COG0346	lactoylglutathione lyase activity
HC658_RS20825	COG1609	Transcriptional regulator
HC658_RS20830	COG0708	Exodeoxyribonuclease III
HC658_RS20835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC658_RS20840	COG0629	single-stranded DNA binding
HC658_RS20845	COG0360	Binds together with S18 to 16S ribosomal RNA
HC658_RS20850	COG0012	GTP binding
HC658_RS20855	COG0243	molybdopterin cofactor binding
HC658_RS20860	COG4481	Protein conserved in bacteria
HC658_RS20865	COG3949	Membrane
HC658_RS20875	COG1475	DNA binding
HC658_RS20880	COG1192	Involved in chromosome partitioning
HC658_RS20890	COG1475	DNA binding
HC658_RS20895	COG0357	Ribosomal RNA small subunit methyltransferase G
HC658_RS20900	COG0445	tRNA wobble uridine modification
HC658_RS20905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC658_RS20910	COG1847	R3H domain protein
HC658_RS20915	COG0706	membrane insertase activity
HC658_RS20920	COG0594	ribonuclease P activity