locus-tag class description Q433_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Q433_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Q433_RS00015 ENOG410848D S4 domain protein YaaA Q433_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Q433_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Q433_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Q433_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Q433_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Q433_RS00100 ENOG4105ZMH deoxynucleoside kinase Q433_RS00110 ENOG4105VRS hydrolase family 18 Q433_RS00115 ENOG4105GTG Isochorismatase Q433_RS00120 ENOG4108Z6B deaminase Q433_RS00125 ENOG4105C6E dna polymerase iii Q433_RS00130 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Q433_RS00135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Q433_RS00145 ENOG41067KS pro-sigma K processing Q433_RS00185 ENOG4105CDW Resistance protein Q433_RS00190 ENOG4105CXN decarboxylase Q433_RS00195 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Q433_RS00200 ENOG4105X0R protein from nitrogen regulatory protein P-II Q433_RS00205 ENOG4105XVJ Protein of unknown function (DUF327) Q433_RS00210 ENOG4105FA2 dna polymerase iii Q433_RS00215 ENOG4105MA4 psp1 domain protein Q433_RS00220 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) Q433_RS00225 ENOG41060K3 Methyltransferase Q433_RS00230 ENOG4105VC4 domain protein Q433_RS00235 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Q433_RS00240 ENOG4105KRN Transcriptional regulator, abrb family Q433_RS00245 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Q433_RS00250 ENOG4105F8V Hydrolase, tatD family Q433_RS00255 ENOG41069ER domain protein Q433_RS00265 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Q433_RS00270 ENOG4105XFA sporulation peptidase YabG Q433_RS00275 ENOG4105W42 Veg protein Q433_RS00280 ENOG4105XEW small acid-soluble spore protein Q433_RS00285 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Q433_RS00290 ENOG4105DFT pur operon repressor Q433_RS00295 ENOG4105KME endoribonuclease L-psp Q433_RS00300 ENOG4105K4W Could be involved in septation (By similarity) Q433_RS00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Q433_RS00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Q433_RS00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Q433_RS00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Q433_RS00335 ENOG4108JA2 transcriptioN-repair coupling factor Q433_RS00340 ENOG4108M14 stage v sporulation protein t Q433_RS00350 ENOG4108IY2 MazG family Q433_RS00355 ENOG41082I2 s4 domain protein Q433_RS00360 ENOG4105VYY sporulation protein yabp Q433_RS00375 ENOG41060GV RNA binding s1 domain protein Q433_RS00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Q433_RS00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase Q433_RS00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Q433_RS00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Q433_RS00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase Q433_RS00435 ENOG4105C6T cysteine synthase Q433_RS00440 ENOG4105CRQ synthase (Component I) Q433_RS00445 ENOG4105DDQ anthranilate synthase Q433_RS00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 Q433_RS00455 ENOG4105EEI dihydropteroate synthase Q433_RS00460 ENOG4105KRF dihydroneopterin aldolase Q433_RS00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Q433_RS00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Q433_RS00480 ENOG4105CRK lysyL-tRNA synthetase Q433_RS00570 ENOG4108Z0C Uvrb UvrC protein Q433_RS00575 ENOG41066A3 ATP guanido phosphotransferase Q433_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Q433_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Q433_RS00595 ENOG4105CTP PilT protein domain protein Q433_RS00600 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Q433_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Q433_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Q433_RS00620 ENOG4105D7W serine acetyltransferase Q433_RS00625 ENOG4105C8N cysteinyl-tRNA synthetase Q433_RS00630 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) Q433_RS00635 ENOG4105C2N RNA methyltransferase TrmH family group 3 Q433_RS00640 ENOG4105M0M Tetracycline resistance protein Q433_RS00660 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Q433_RS00675 ENOG4108VZM 50s ribosomal protein L10 Q433_RS00685 ENOG4107Y49 methyltransferase Q433_RS00690 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Q433_RS00695 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Q433_RS00700 ENOG4105XPM ribosomal protein Q433_RS00705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Q433_RS00710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Q433_RS00715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Q433_RS00720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Q433_RS00725 ENOG4107SKW Inherit from COG: Alpha beta hydrolase Q433_RS00730 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Q433_RS00735 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Q433_RS00740 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Q433_RS00750 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Q433_RS00765 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Q433_RS00770 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Q433_RS00780 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Q433_RS00785 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Q433_RS00795 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Q433_RS00805 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Q433_RS00810 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Q433_RS00815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Q433_RS00820 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Q433_RS00830 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Q433_RS00835 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Q433_RS00845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Q433_RS00860 ENOG41067V7 50S ribosomal protein L36 Q433_RS00865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Q433_RS00870 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Q433_RS00875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Q433_RS00880 ENOG4108ZT0 50S ribosomal protein l17 Q433_RS00885 ENOG4108JJB ABC transporter Q433_RS00890 ENOG4108JJB ABC transporter Q433_RS00895 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Q433_RS00900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Q433_RS00905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Q433_RS00910 ENOG4108UJD 30S ribosomal protein S9 Q433_RS00915 ENOG4108I0C methyltransferase Q433_RS00945 ENOG4108NMV polysaccharide deacetylase Q433_RS00970 ENOG4105CHH sulfate transporter Q433_RS00980 ENOG4108SA1 esterase Q433_RS01000 ENOG410874W AraC family transcriptional regulator Q433_RS01005 ENOG4105EHZ conserved protein UCP016719 Q433_RS01010 ENOG4105D17 glycoside hydrolase, family 3 domain protein Q433_RS01030 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Q433_RS01040 ENOG4105EWC Purine nucleoside phosphorylase Q433_RS01070 ENOG4105EMN RNA polymerase sigma factor Q433_RS01080 ENOG4105C8B TIGR00159 family Q433_RS01085 ENOG4107U5W ybbr family Q433_RS01090 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Q433_RS01095 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Q433_RS01100 ENOG4105D03 DNA-3-methyladenine glycosylase II Q433_RS01110 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Q433_RS01115 ENOG4108TWJ NADH dehydrogenase subunit 5 Q433_RS01135 ENOG4105GPN Uncharacterized conserved protein (DUF2294) Q433_RS01145 ENOG4105WAB arsR family transcriptional regulator Q433_RS01150 ENOG4108RWP Major Facilitator Superfamily protein Q433_RS01165 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS01185 ENOG4105BZ1 (ABC) transporter Q433_RS01210 ENOG4105G0J serine threonine protein kinase Q433_RS01220 ENOG4106K80 Q433_RS01230 ENOG4106DDH Sporulation-specific SASP protein Q433_RS01240 ENOG4108HWY Beta-lactamase Q433_RS01245 ENOG4107E6A Cytochrome p-450 Q433_RS01255 ENOG4107QTZ amino acid Q433_RS01260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Q433_RS01265 ENOG4105CXY transporter Q433_RS01275 ENOG410645S MarR family Transcriptional regulator Q433_RS01280 ENOG4105DCM major facilitator superfamily Q433_RS01295 ENOG410631K Membrane Q433_RS01300 ENOG4106AXJ AraC family transcriptional regulator Q433_RS01305 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Q433_RS01310 ENOG4108TCS Glutamyl endopeptidase Q433_RS01320 ENOG4108WC5 Alpha Beta Hydrolase Fold protein Q433_RS01325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Q433_RS01330 ENOG4107ZTW SNARE associated Golgi Q433_RS01345 ENOG4105C72 UPF0176 protein Q433_RS01355 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane Q433_RS01360 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Q433_RS01375 ENOG4105CM2 brancheD-chain amino acid aminotransferase Q433_RS01380 ENOG4108IQI permease Q433_RS01385 ENOG4108J5H Homocysteine s-methyltransferase Q433_RS01400 ENOG4105CSV Glutaminase Q433_RS01415 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Q433_RS01420 ENOG4105C26 Dehydrogenase Q433_RS01425 ENOG4105DJB Major Facilitator Superfamily Q433_RS01430 ENOG4105EQX glucarate dehydratase Q433_RS01435 ENOG41073TP transcriptional regulator Q433_RS01440 ENOG4105CTX dehydratase Q433_RS01455 ENOG4106UX7 integral membrane protein Q433_RS01460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Q433_RS01495 ENOG4105MUA Resistance protein Q433_RS01505 ENOG4105DGI Alkaline phosphatase Q433_RS01510 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Q433_RS01515 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Q433_RS01520 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) Q433_RS01525 ENOG4107EPV Aminotransferase class V Q433_RS01530 ENOG4105C0R drug resistance transporter emrb qaca subfamily Q433_RS01535 ENOG4105J7D transcriptional regulator Q433_RS01540 ENOG4107RB3 L-asparaginase Q433_RS01545 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold Q433_RS01555 ENOG41060AI SEC-C motif Q433_RS01565 ENOG4107Y7X LytTR Q433_RS01570 ENOG4108IUW ABC transporter Q433_RS01575 ENOG4108SDH ABC, transporter Q433_RS01580 ENOG4107SET aldo keto reductase Q433_RS01610 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Q433_RS01620 ENOG4105DSE periplasmic solute binding protein Q433_RS01625 ENOG4105DIK (ABC) transporter Q433_RS01635 ENOG4105DEN Luciferase family Q433_RS01640 ENOG4108N0M stress protein Q433_RS01645 ENOG4106FN3 tellurium resistance protein Q433_RS01650 ENOG4106FN3 tellurium resistance protein Q433_RS01655 ENOG4107TS3 membrane protein, TerC Q433_RS01660 ENOG4108TTB tellurium resistance protein Q433_RS01670 ENOG41079KZ Major Facilitator Superfamily Q433_RS01675 ENOG4107XZQ multidrug resistance protein Q433_RS01680 ENOG4108A65 Transcriptional regulator Q433_RS01685 ENOG4108IJ7 Glycine betaine Q433_RS01690 ENOG4107SQ8 Glycine betaine Q433_RS01725 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Q433_RS01760 ENOG4105EIG urea carboxylase-associated protein 1 Q433_RS01765 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Q433_RS01770 ENOG4105I1F Resistance protein Q433_RS01775 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Q433_RS01780 ENOG41089UC methyltransferase, type 11 Q433_RS01785 ENOG4105C5Q Transcriptional regulator Q433_RS01790 ENOG4105I82 acetyl xylan esterase Q433_RS01795 ENOG410756H nucleotidyltransferase Q433_RS01805 ENOG4105C26 Dehydrogenase Q433_RS01810 ENOG4105CK7 Sodium proline symporter Q433_RS01815 ENOG4107YHD transcriptional regulator Q433_RS01825 ENOG4108PJD permease Q433_RS01830 ENOG4105U6C Alpha beta hydrolase fold protein Q433_RS01840 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Q433_RS01845 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit Q433_RS01850 ENOG4108IFG nitrite reductase, (NAD(P)H) Q433_RS01855 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Q433_RS01875 ENOG4105S7A ErfK ybiS ycfS ynhG family protein Q433_RS01885 ENOG4105CKI cobalamin synthesis protein Q433_RS01890 ENOG4105E5Q amino acid AbC transporter Q433_RS01895 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein Q433_RS01905 ENOG4105HHM rdd domain containing protein Q433_RS01915 ENOG4105CS2 ec 3.2.1.21 Q433_RS01930 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS01935 ENOG41080HJ 6-phospho 3-hexuloisomerase Q433_RS01940 ENOG4108VA3 3-hexulose-6-phosphate synthase Q433_RS01945 ENOG4105KVH Transcriptional regulator Q433_RS01955 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS01985 ENOG4105SX7 Transporter Q433_RS01995 ENOG4105W8Z 4'-phosphopantetheinyl transferase Q433_RS02005 ENOG4105CDA abc transporter atp-binding protein Q433_RS02010 ENOG4105DRP amino acid AbC transporter Q433_RS02020 ENOG4106P55 Transcriptional regulator Q433_RS02025 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Q433_RS02030 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Q433_RS02035 ENOG41069ZX Q433_RS02040 ENOG41069ZX Q433_RS02050 ENOG4105DUX Transporter Q433_RS02065 ENOG4105E1K spore germination protein Q433_RS02085 ENOG4107WD8 ABC transporter, permease Q433_RS02090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Q433_RS02095 ENOG4105BZU Histidine kinase Q433_RS02120 ENOG4105CFH Aspartokinase Q433_RS02125 ENOG4105DHS permease protein Q433_RS02130 ENOG4105CM4 permease protein Q433_RS02135 ENOG4108IPW abc transporter atp-binding protein Q433_RS02150 ENOG4105R8C Transcriptional regulator Q433_RS02155 ENOG4108DBC nitroreductase Q433_RS02160 ENOG41067V3 Antibiotic biosynthesis monooxygenase Q433_RS02165 ENOG4105YVS arsR family transcriptional regulator Q433_RS02175 ENOG4108JPW Aminotransferase Q433_RS02180 ENOG4105C26 Dehydrogenase Q433_RS02190 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Q433_RS02195 ENOG4105KTB nuclear export factor GLE1 Q433_RS02200 ENOG4108T5E Copper resistance protein Q433_RS02205 ENOG4108ZYE Transcriptional regulator Q433_RS02230 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Q433_RS02235 ENOG4108ZX0 Signal peptidase I Q433_RS02265 ENOG4105E7W lamb ycsf family protein Q433_RS02270 ENOG4105C5A transporter Q433_RS02280 ENOG4105P4J Allophanate hydrolase, subunit 1 Q433_RS02290 ENOG4107258 Transcriptional regulator Q433_RS02295 ENOG4105XJB lipolytic protein G-D-S-L family Q433_RS02305 ENOG41061CK Antibiotic biosynthesis monooxygenase Q433_RS02310 ENOG4107RVG penicillin-binding protein Q433_RS02315 ENOG4107QM2 Aldo Keto reductase Q433_RS02320 ENOG4105ETD TRANSCRIPTIONal Q433_RS02330 ENOG4105HMZ Methyltransferase Q433_RS02335 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Q433_RS02350 ENOG410606W general stress protein Q433_RS02360 ENOG4105VCH membrane Q433_RS02370 ENOG4105C9U ATP-dependent DNA helicase RecQ Q433_RS02385 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) Q433_RS02390 ENOG4107R8N Glycosyl transferase, family 2 Q433_RS02400 ENOG4105C0X amino acid Q433_RS02425 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Q433_RS02435 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) Q433_RS02440 ENOG4105EU9 Q433_RS02445 ENOG4105QVS general stress protein Q433_RS02450 ENOG41082W1 Cupin 2, conserved barrel domain protein Q433_RS02465 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit Q433_RS02470 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Q433_RS02475 ENOG4108MRH transcriptional regulatory protein Q433_RS02480 ENOG4107QJT sodium dicarboxylate symporter Q433_RS02485 ENOG4106F5Q Membrane Q433_RS02495 ENOG4105CJ1 ABC, transporter Q433_RS02510 ENOG4105FDT acyl-CoA dehydrogenase Q433_RS02530 ENOG4105SZ6 Thioredoxin Q433_RS02535 ENOG4105CPF Cell wall formation (By similarity) Q433_RS02540 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Q433_RS02545 ENOG4105C1J atp-dependent rna helicase Q433_RS02550 ENOG410905X membrane-flanked domain protein Q433_RS02555 ENOG4105CKV Membrane Q433_RS02565 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Q433_RS02570 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein Q433_RS02575 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Q433_RS02585 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Q433_RS02590 ENOG4107MMM Anti-sigma-factor antagonist Q433_RS02595 ENOG4105FUA antagonist Q433_RS02600 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase Q433_RS02605 ENOG4107SGM protein serine threonine phosphatase Q433_RS02610 ENOG4105WN5 stage II sporulation protein Q433_RS02615 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Q433_RS02625 ENOG41064BQ Phosphatase Q433_RS02690 ENOG4105VZ8 Transcriptional regulator Q433_RS02715 ENOG4108V4B ThiJ pfpI Q433_RS02720 ENOG4105VEQ Cold shock protein Q433_RS02735 ENOG4108MCI Transcriptional regulator, ARAC family Q433_RS02740 ENOG4108UZ3 Transporter Q433_RS02750 ENOG4107U9B transcriptional regulator Q433_RS02755 ENOG4105DXI Major Facilitator superfamily Q433_RS02765 ENOG4105CZ9 Domain of unknown function (DU1801) Q433_RS02770 ENOG4105GIG Q433_RS02775 ENOG4105KRI phosphocarrier protein (HPr Q433_RS02780 ENOG4105ST3 Transcriptional regulator Q433_RS02785 ENOG4105T38 integral membrane protein Q433_RS02790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Q433_RS02795 ENOG4108ZMQ domain protein Q433_RS02800 ENOG4105MJ9 esterase Q433_RS02805 ENOG4107Z6X Transcriptional regulator Q433_RS02815 ENOG4105EQ0 Major Facilitator superfamily Q433_RS02820 ENOG4108JGH Tetr family transcriptional regulator Q433_RS02830 ENOG41082YX Transcriptional regulator, arsr family Q433_RS02835 ENOG4107R5R arsenical pump membrane protein Q433_RS02845 ENOG4105Z7P Acetyltransferase (GNAT) family Q433_RS02850 ENOG4107Y9U Membrane Q433_RS02860 ENOG4108SQ9 flavin reductase domain protein, FMN-binding Q433_RS02865 ENOG4108ZHR arsR family transcriptional regulator Q433_RS02870 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Q433_RS02885 ENOG4105ENE Histidine kinase Q433_RS02890 ENOG4108VB1 regulatoR Q433_RS02895 ENOG4105EYF MMPL domain protein Q433_RS02900 ENOG4108WC5 Alpha Beta Hydrolase Fold protein Q433_RS02905 ENOG4108UQV Membrane Q433_RS02910 ENOG4108Z5V transcriptional regulator, merr family Q433_RS02915 ENOG41076HS cation diffusion facilitator family transporter Q433_RS02920 ENOG4108TVJ Nitroreductase Q433_RS02925 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase Q433_RS02930 ENOG4108VGI doxx family Q433_RS02935 ENOG4105XXY Thioredoxin Q433_RS02955 ENOG410900G Protein of unknown function (DUF421) Q433_RS02960 ENOG4108QY0 Membrane Q433_RS02980 ENOG4105PF9 Transcriptional regulator Q433_RS02990 ENOG4105WQG acetyltransferase Q433_RS03000 ENOG4105C85 amino acid Q433_RS03010 ENOG41062A4 Transcriptional regulator Q433_RS03015 ENOG4105EYF MMPL domain protein Q433_RS03020 ENOG4108TVJ Nitroreductase Q433_RS03025 ENOG4105FS7 Transcriptional regulator Q433_RS03030 ENOG4105C2C drug resistance transporter, Bcr CflA Q433_RS03040 ENOG4105DRR Transcriptional regulator, GntR family Q433_RS03045 ENOG4105VRS hydrolase family 18 Q433_RS03060 ENOG4105G6Z alkaline phosphatase Q433_RS03065 ENOG4108ZMX Domain of unknown function (DU1801) Q433_RS03075 ENOG4108YM7 Gcn5-related n-acetyltransferase Q433_RS03080 ENOG4107TVP HD domain protein Q433_RS03085 ENOG41090UD (LipO)protein Q433_RS03090 ENOG4105F27 Major Facilitator Q433_RS03095 ENOG4105VZJ PTS System Q433_RS03100 ENOG4105VCP PTS System Q433_RS03105 ENOG4105CK1 PTS System Q433_RS03110 ENOG4105CS2 ec 3.2.1.21 Q433_RS03115 ENOG4108TZY GntR Family Transcriptional Regulator Q433_RS03120 ENOG4105EVU fructokinase Q433_RS03125 ENOG4105DG6 mannose-6-phosphate isomerase Q433_RS03130 ENOG4105D3P Mannan endo-1,4-beta-mannosidase Q433_RS03175 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Q433_RS03180 ENOG4105K8N protein family UPF0079, ATPase Q433_RS03185 ENOG41072GX Peptidase M22 Glycoprotease Q433_RS03190 ENOG410801F ribosomal-protein-alanine acetyltransferase Q433_RS03195 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Q433_RS03200 ENOG4105C5H ABC transporter Q433_RS03205 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Q433_RS03210 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Q433_RS03215 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Q433_RS03220 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Q433_RS03230 ENOG4108TYN CAAX amino terminal protease family protein Q433_RS03240 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Q433_RS03250 ENOG4105PGZ NB-ARC domain Q433_RS03255 ENOG4105CPQ Dehydrogenase Q433_RS03260 ENOG4105CT4 transporter Q433_RS03270 ENOG41087YS Phage shock protein A Q433_RS03275 ENOG4105DQX Zinc finger domain Q433_RS03280 ENOG4108WV1 Pfam:DUF477 Q433_RS03290 ENOG4108ZMR Ion transport 2 domain-containing protein Q433_RS03295 ENOG4107QNK )-transporter Q433_RS03325 ENOG4107YUH hydrolase Q433_RS03335 ENOG4107STQ Multicopper oxidase Q433_RS03340 ENOG4105C85 amino acid Q433_RS03355 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Q433_RS03375 ENOG4105C7N Xanthine uracil vitamin C permease Q433_RS03400 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Q433_RS03405 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Q433_RS03410 ENOG4105C83 adenylosuccinate lyase Q433_RS03415 ENOG4105C8V SAICAR synthetase Q433_RS03420 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Q433_RS03425 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Q433_RS03430 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Q433_RS03440 ENOG4105CXB phosphoribosylaminoimidazole synthetase Q433_RS03445 ENOG4108V3E phosphoribosylglycinamide formyltransferase Q433_RS03450 ENOG4105DC1 bifunctional purine biosynthesis protein purh Q433_RS03455 ENOG4105C12 Phosphoribosylglycinamide synthetase Q433_RS03465 ENOG4105DVH amino acid Q433_RS03480 ENOG4108R5T secreted protein Q433_RS03485 ENOG4105KGF protein, YerC YecD Q433_RS03490 ENOG4105CBC glutamate synthase Q433_RS03495 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) Q433_RS03500 ENOG4105C4R Atp-dependent dna helicase Q433_RS03505 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Q433_RS03515 ENOG4105CRN Aminoglycoside phosphotransferase Q433_RS03520 ENOG4105KT7 mgtC SapB transporter Q433_RS03525 ENOG4105CK7 Sodium proline symporter Q433_RS03530 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Q433_RS03535 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Q433_RS03540 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Q433_RS03545 ENOG4108IG5 Transcriptional regulator Q433_RS03555 ENOG4105CBD Diacylglycerol kinase Q433_RS03560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Q433_RS03605 ENOG4105CDY transcriptional regulatory protein Q433_RS03615 ENOG4105M4P Tetr family transcriptional regulator Q433_RS03620 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein Q433_RS03625 ENOG4107S9F NmrA family Q433_RS03640 ENOG4105WEF catalase Q433_RS03645 ENOG4105M18 -acetyltransferase Q433_RS03660 ENOG4105C2F Histidine kinase Q433_RS03665 ENOG4105EQD regulatoR Q433_RS03670 ENOG410769Z extracellular solute-binding protein family 1 Q433_RS03675 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Q433_RS03680 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Q433_RS03685 ENOG4105F5H Glycosyl Hydrolase Family 88 Q433_RS03690 ENOG41075H3 AraC family transcriptional regulator Q433_RS03695 ENOG4107TDE lipolytic protein G-D-S-L family Q433_RS03710 ENOG4105CX8 fg-gap repeat protein Q433_RS03715 ENOG4105CX8 fg-gap repeat protein Q433_RS03720 ENOG4107TDE lipolytic protein G-D-S-L family Q433_RS03730 ENOG4105EKC Q433_RS03735 ENOG4105E0S extracellular solute-binding protein family 1 Q433_RS03745 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Q433_RS03750 ENOG4105F8D glycoside hydrolase family 4 Q433_RS03755 ENOG4105H67 Protein of unknown function (DUF421) Q433_RS03760 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) Q433_RS03765 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Q433_RS03785 ENOG4106I4J membrane Q433_RS03790 ENOG4108PCN EamA-like transporter family Q433_RS03795 ENOG41082F9 transcriptional regulator Q433_RS03800 ENOG41061H0 Monooxygenase Q433_RS03810 ENOG4108R1P Q433_RS03815 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Q433_RS03820 ENOG4105E0M Sulfatase Q433_RS03825 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Q433_RS03835 ENOG41090R9 glycosyltransferase Q433_RS03840 ENOG4107R51 Glycosyl transferase, family 2 Q433_RS03845 ENOG41090R9 glycosyltransferase Q433_RS03850 ENOG4105EU0 Major facilitator Superfamily Q433_RS03860 ENOG4105CUB amino acid Q433_RS03865 ENOG4105C26 Dehydrogenase Q433_RS03870 ENOG4105FKZ Methyl-accepting chemotaxis Q433_RS03875 ENOG4105C5H ABC transporter Q433_RS03885 ENOG4107SWG transcriptional regulator MERR family Q433_RS03890 ENOG4105DXB Major Facilitator superfamily Q433_RS03910 ENOG4105C5H ABC transporter Q433_RS03915 ENOG4105FDU atp-dependent rna helicase Q433_RS03925 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Q433_RS03945 ENOG4105E6M Sulphatase-modifying factor protein Q433_RS03950 ENOG4105E0A ABC, transporter Q433_RS03955 ENOG4108U1V ABC transporter, permease Q433_RS03960 ENOG4105DQ5 transport system permease protein Q433_RS03965 ENOG4108HUF Transporter Q433_RS03980 ENOG4108J20 pectate lyase Q433_RS03985 ENOG4107QPK )-transporter Q433_RS03995 ENOG4108MRH transcriptional regulatory protein Q433_RS04025 ENOG410855V Acylphosphatase Q433_RS04030 ENOG4108RPX mosc domain containing protein Q433_RS04050 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) Q433_RS04075 ENOG4105GEU Spore germination protein Q433_RS04085 ENOG4108Q5U germination protein, ger(x)c family Q433_RS04090 ENOG4105E1K spore germination protein Q433_RS04095 ENOG4105C5Y PTS System Q433_RS04100 ENOG4105CG3 alpha amylase, catalytic region Q433_RS04105 ENOG4107414 GntR family transcriptional regulator Q433_RS04110 ENOG4108RCM Nitroreductase Q433_RS04115 ENOG4105CGH 5'-nucleotidase Q433_RS04120 ENOG4107RKG DJ-1/PfpI family Q433_RS04135 ENOG4105KJF protein tyrosine phosphatase Q433_RS04145 ENOG4107U9T Pfam:Ribonuclease_BN Q433_RS04155 ENOG4108ISG Major Facilitator Q433_RS04165 ENOG4105UPD Calcium Proton Q433_RS04175 ENOG4105D8X mechanosensitive ion channel Q433_RS04195 ENOG4106KE4 Dehydrogenase Q433_RS04200 ENOG4105D7N magnesium and cobalt transport protein CorA Q433_RS04210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Q433_RS04230 ENOG4107RUY (E1 component), alpha subunit Q433_RS04240 ENOG4107QKR Dehydrogenase Q433_RS04250 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Q433_RS04255 ENOG41069DP small acid-soluble spore protein Q433_RS04260 ENOG4105KK4 UPF0060 membrane protein Q433_RS04285 ENOG4105F8D glycoside hydrolase family 4 Q433_RS04290 ENOG4108Q3X Transcriptional regulator Q433_RS04295 ENOG4105CI1 PTS System Q433_RS04305 ENOG4105BZ1 (ABC) transporter Q433_RS04310 ENOG4105BZ1 (ABC) transporter Q433_RS04320 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS04325 ENOG4105BZU Histidine kinase Q433_RS04330 ENOG4105WH1 Two component transcriptional regulator luxr family Q433_RS04335 ENOG4105CJ1 ABC, transporter Q433_RS04340 ENOG41090VJ ABC-2 type transporter Q433_RS04345 ENOG4108KYE ABC-2 type transporter Q433_RS04350 ENOG4105U3E Transcriptional regulator Q433_RS04355 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold Q433_RS04360 ENOG4105H93 Acyltransferase family Q433_RS04365 ENOG4108YYS metal-dependent hydrolase (By similarity) Q433_RS04370 ENOG4105C0R drug resistance transporter emrb qaca subfamily Q433_RS04375 ENOG410834F Transcriptional regulator Q433_RS04385 ENOG4108MES Periplasmic binding protein Q433_RS04390 ENOG4105DQ5 transport system permease protein Q433_RS04395 ENOG4108IHU transport system permease protein Q433_RS04400 ENOG4105JAB phenazine biosynthesis protein, phzf family Q433_RS04405 ENOG4107Y03 Nitroreductase Q433_RS04420 ENOG4105ECP epimerase Q433_RS04440 ENOG4105F27 Major Facilitator Q433_RS04460 ENOG4106AKJ Q433_RS04465 ENOG4105D74 hydrolase Q433_RS04475 ENOG4105EJV Membrane Q433_RS04480 ENOG41067AE Membrane-bound metal-dependent hydrolase Q433_RS04485 ENOG4105CEN a g-specific adenine glycosylase Q433_RS04490 ENOG4106BXE Q433_RS04495 ENOG4105CAN Short-chain dehydrogenase reductase Sdr Q433_RS04510 ENOG4105EVI UPF0374 protein Q433_RS04515 ENOG4105BZ1 (ABC) transporter Q433_RS04520 ENOG4107NBY Membrane Q433_RS04530 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Q433_RS04535 ENOG4105G5W regulator Fur family Q433_RS04650 ENOG4108N23 SpoOM-related protein Q433_RS04665 ENOG4105EC3 peptidase S51, dipeptidase E Q433_RS04670 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Q433_RS04675 ENOG4105DNP FAD linked oxidase domain protein Q433_RS04690 ENOG4105E2Y ABC, transporter Q433_RS04695 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein Q433_RS04700 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Q433_RS04705 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Q433_RS04715 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Q433_RS04720 ENOG4107D63 Q433_RS04725 ENOG4105VZ8 Transcriptional regulator Q433_RS04740 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Q433_RS04750 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Q433_RS04770 ENOG4105CYN Serine protein kinase Q433_RS04775 ENOG4106AKX UPF0229 protein Q433_RS04785 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes Q433_RS04790 ENOG4105CW7 secretion protein, HlyD family Q433_RS04795 ENOG4105C0R drug resistance transporter emrb qaca subfamily Q433_RS04800 ENOG4105CS1 NAD(P)H quinone oxidoreductase Q433_RS04815 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Q433_RS04820 ENOG4105CZV ABC transporter Q433_RS04825 ENOG4105CJ1 ABC, transporter Q433_RS04830 ENOG4108TU7 Inherit from COG: (ABC) transporter Q433_RS04835 ENOG4105VEQ Cold shock protein Q433_RS04850 ENOG4105BZU Histidine kinase Q433_RS04890 ENOG4108YBP pseudouridine synthase Q433_RS04900 ENOG41080XP Cbs domain Q433_RS04905 ENOG4107YBY Hydrolase Q433_RS04910 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Q433_RS04915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Q433_RS04920 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Q433_RS04930 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Q433_RS04935 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Q433_RS04945 ENOG4105BZU Histidine kinase Q433_RS04950 ENOG4105WH1 Two component transcriptional regulator luxr family Q433_RS04985 ENOG4105ED1 spovr family Q433_RS04990 ENOG4105G6Z alkaline phosphatase Q433_RS05005 ENOG4105BZN citrate synthase Q433_RS05010 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Q433_RS05015 ENOG4105CUB amino acid Q433_RS05020 ENOG4105C8J )-transporter Q433_RS05025 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Q433_RS05040 ENOG4105J37 Q433_RS05045 ENOG4108AEY RNA polymerase sigma factor Q433_RS05050 ENOG4108FN7 Aldo keto reductase Q433_RS05055 ENOG4105F6E Acyl-transferase Q433_RS05060 ENOG4105C37 (CBS) domain Q433_RS05070 ENOG4105CHM Aminotransferase Q433_RS05075 ENOG4105C37 (CBS) domain Q433_RS05085 ENOG4105WMR Protein CrcB homolog Q433_RS05090 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Q433_RS05100 ENOG4105D64 Mechanosensitive ion channel Q433_RS05105 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Q433_RS05110 ENOG4107VMI polysaccharide deacetylase Q433_RS05115 ENOG4105F0I Aminotransferase Q433_RS05135 ENOG4105BZ1 (ABC) transporter Q433_RS05140 ENOG4105BZ1 (ABC) transporter Q433_RS05160 ENOG410839P Q433_RS05170 ENOG4106MP8 UPF0754 membrane protein Q433_RS05175 ENOG4105WZB UPF0342 protein Q433_RS05180 ENOG4105F1N DNA alkylation repair Q433_RS05190 ENOG4105D4P Coproporphyrinogen iii oxidase Q433_RS05195 ENOG4107S91 Sodium hydrogen exchanger Q433_RS05200 ENOG4105NCW Trka-c domain protein Q433_RS05210 ENOG4105CGU Enoyl-CoA hydratase Q433_RS05220 ENOG4108IUX (ABC) transporter Q433_RS05225 ENOG4105RHA ABC transporter, permease Q433_RS05230 ENOG4107VRP DNA repair exonuclease Q433_RS05235 ENOG4106D4I domain protein Q433_RS05240 ENOG4105EQI Metal Dependent Phosphohydrolase Q433_RS05250 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Q433_RS05290 ENOG4105NBU tryptophan transport protein Q433_RS05295 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Q433_RS05300 ENOG4105K59 histidine triad (HIT) protein Q433_RS05335 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation Q433_RS05340 ENOG4105BZ4 penicillin-binding protein Q433_RS05345 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Q433_RS05350 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Q433_RS05355 ENOG4105C1Q protoporphyrinogen oxidase Q433_RS05365 ENOG4105ECB domain protein Q433_RS05375 ENOG41090T1 Membrane Q433_RS05385 ENOG4105DER m42 family Q433_RS05400 ENOG4106AXD Q433_RS05405 ENOG4108RQ5 Beta-lactamase domain-containing protein Q433_RS05410 ENOG4105DF9 Lipoate-protein, ligase Q433_RS05420 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS05430 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 Q433_RS05435 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS05450 ENOG4108HUF Transporter Q433_RS05455 ENOG4107TB6 phosphoglycerate mutase Q433_RS05465 ENOG4107F3J Amp-dependent synthetase and ligase Q433_RS05470 ENOG4107ZYJ bioY protein Q433_RS05475 ENOG4106YBV Methyl-accepting chemotaxis Q433_RS05495 ENOG4105XVF Competence transcription factor Q433_RS05500 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Q433_RS05505 ENOG4105X3H Excalibur domain protein Q433_RS05510 ENOG4105E1V na solute symporter Q433_RS05515 ENOG4106CAD Protein of unknown function (DUF3311) Q433_RS05520 ENOG41060YP Q433_RS05535 ENOG4107SCK Monooxygenase Q433_RS05540 ENOG4108INS Transcriptional regulator Q433_RS05555 ENOG4105TRI Hydrolase Q433_RS05570 ENOG4108KK1 membrane protein AbrB duplication Q433_RS05575 ENOG4106K7D Major facilitator family transporter Q433_RS05580 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) Q433_RS05585 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding Q433_RS05600 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Q433_RS05610 ENOG4105EYH Exonuclease Q433_RS05665 ENOG4105ERH Fumarylacetoacetate hydrolase Q433_RS05675 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS05685 ENOG4105CAQ asparagine synthetase Q433_RS05700 ENOG4105UQX Mate efflux family protein Q433_RS05705 ENOG4106HBX Transcriptional Regulator AraC Family Q433_RS05710 ENOG4105ETE Transcriptional regulator (LacI family Q433_RS05715 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Q433_RS05720 ENOG4105SF0 DinB family Q433_RS05725 ENOG4108ZUB Lysine exporter protein (Lyse ygga) Q433_RS05730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Q433_RS05735 ENOG4105MYW Pentapeptide repeat protein Q433_RS05740 ENOG4107S9D Alpha beta hydrolase Q433_RS05745 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Q433_RS05750 ENOG4107RIQ Sulfate adenylate transferase Q433_RS05755 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Q433_RS05760 ENOG4108N5B 2-phosphosulfolactate phosphatase Q433_RS05765 ENOG41061P3 phosphosulfolactate synthase Q433_RS05775 ENOG4105DIA mandelate racemase muconate lactonizing Q433_RS05780 ENOG4107RCC Major Facilitator Superfamily Q433_RS05785 ENOG4108SZE gCN5-related N-acetyltransferase Q433_RS05790 ENOG4105MA6 gCN5-related N-acetyltransferase Q433_RS05800 ENOG4108VPT UPF0234 protein Q433_RS05805 ENOG4105QNR S1 RNA binding domain protein Q433_RS05825 ENOG4105K7K Transcriptional regulator Q433_RS05835 ENOG410751J Q433_RS05840 ENOG4105D4Y metalloprotease Q433_RS05845 ENOG4105EPR degv family Q433_RS05850 ENOG4107AYK membrAne Q433_RS05860 ENOG41073B9 Q433_RS05870 ENOG4108KP7 hydrolase Q433_RS05875 ENOG4108MXZ Esterase Q433_RS05880 ENOG4105VG1 fes assembly suf system protein Q433_RS05890 ENOG4105IQ5 FAD linked oxidase domain protein Q433_RS05900 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Q433_RS05905 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Q433_RS05915 ENOG4105C8Y Acetylornithine aminotransferase Q433_RS05920 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Q433_RS05930 ENOG4105DBV ornithine carbamoyltransferase Q433_RS05955 ENOG4107RMD Basic membrane lipoprotein Q433_RS05970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Q433_RS05975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Q433_RS05985 ENOG4105C3U ABC transporter Q433_RS05990 ENOG4108JQ7 (ABC) transporter Q433_RS06005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Q433_RS06015 ENOG4105C31 Tryptophanyl-tRNA synthetase Q433_RS06020 ENOG4108J59 Extracellular solute-binding protein, family 5 Q433_RS06025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Q433_RS06030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Q433_RS06040 ENOG4108JQ7 (ABC) transporter Q433_RS06055 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) Q433_RS06060 ENOG4108ZCF integral membrane protein Q433_RS06065 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis Q433_RS06075 ENOG4105DPN Oligoendopeptidase f Q433_RS06090 ENOG4105T58 Dithiol-disulfide isomerase Q433_RS06095 ENOG4108Z18 K06886 hemoglobin Q433_RS06100 ENOG4105E4C Lytic transglycosylase catalytic Q433_RS06105 ENOG4105MIX Adenylate cyclase Q433_RS06120 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Q433_RS06125 ENOG4105EMS pseudouridine synthase Q433_RS06140 ENOG4105ETU transcriptional activator (TenA Q433_RS06145 ENOG4108VEU Thiamine monophosphate synthase Q433_RS06160 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Q433_RS06165 ENOG4105D06 uba thif-type nad fad binding protein Q433_RS06170 ENOG4105DWF phosphomethylpyrimidine kinase Q433_RS06175 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Q433_RS06180 ENOG4107A88 Q433_RS06235 ENOG4105ENA helicase Q433_RS06250 ENOG4108ZMI UPF0477 protein Q433_RS06260 ENOG4105C28 cystathionine Q433_RS06265 ENOG4105C28 cystathionine Q433_RS06275 ENOG4105JHY Membrane Q433_RS06300 ENOG4106BHF Q433_RS06345 ENOG4108PSK reductase Q433_RS06360 ENOG4105DM4 PTS System Q433_RS06365 ENOG4105DG6 mannose-6-phosphate isomerase Q433_RS06370 ENOG4105G7B Protein of unknown function (DUF2992) Q433_RS06375 ENOG4105VMI -acetyltransferase Q433_RS06385 ENOG4108Z66 YbaK ebsC protein Q433_RS06400 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Q433_RS06410 ENOG4108ZJ4 polysaccharide deacetylase Q433_RS06415 ENOG4107CUJ Protein of unknown function (DUF2690) Q433_RS06445 ENOG4108IEG Formate dehydrogenase Alpha subunit Q433_RS06470 ENOG4106A3M Cytochrome p-450 Q433_RS06475 ENOG41087PP glycosyltransferase MGT family Q433_RS06485 ENOG4105EXQ uroporphyrinogen iii synthase hem4 Q433_RS06490 ENOG4105C4B ABC transporter, permease Q433_RS06495 ENOG4108IXI (ABC) transporter Q433_RS06505 ENOG4105Q95 Cupin 2, conserved barrel domain protein Q433_RS06520 ENOG4105D2H Uronic isomerase Q433_RS06525 ENOG4105CT4 transporter Q433_RS06530 ENOG4105DG4 malate L-lactate dehydrogenase Q433_RS06535 ENOG4105CPQ Dehydrogenase Q433_RS06540 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) Q433_RS06545 ENOG4105DMW Dehydrogenase reductase Q433_RS06550 ENOG4108I5G Major Facilitator superfamily Q433_RS06555 ENOG4107KJX Transcriptional regulator Q433_RS06560 ENOG4107QZW Altronate oxidoreductase Q433_RS06565 ENOG4105CTX dehydratase Q433_RS06570 ENOG4107TSN permease Q433_RS06580 ENOG4105JD4 ATPase yjob Q433_RS06595 ENOG41068K0 YCII-related domain Q433_RS06600 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase Q433_RS06605 ENOG4105KWG Pfam:DUF1696 Q433_RS06610 ENOG4105K7W phage-related replication protein Q433_RS06615 ENOG4105WEF catalase Q433_RS06620 ENOG410635T phage-like element pbsx protein Q433_RS06670 ENOG4108TFU terminase (Small subunit) Q433_RS06675 ENOG4105IG6 Phage terminase, large subunit Q433_RS06680 ENOG4108MDF Phage Portal Protein Q433_RS06705 ENOG41060SN Q433_RS06720 ENOG4105PQS phage protein Q433_RS06725 ENOG4105FR7 XkdM protein, phage-like element PBSX Q433_RS06730 ENOG4105MTC XkdN-like protein Q433_RS06740 ENOG4108FKH Transglycosylase SLT domain Q433_RS06740 ENOG4108FKH Transglycosylase SLT domain Q433_RS06745 ENOG4108WZM domain protein Q433_RS06750 ENOG4105X7F Q433_RS06760 ENOG4105MFU Protein of unknown function (DUF2634) Q433_RS06765 ENOG41066EA baseplate J family protein Q433_RS06770 ENOG410906S phage-like element pbsx protein xkdt Q433_RS06780 ENOG41068G1 Q433_RS06810 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Q433_RS06825 ENOG4105CJ3 phosphate transporter Q433_RS06830 ENOG4107GRR phosphate transport regulator Q433_RS06835 ENOG4107R7I amino acid Q433_RS06845 ENOG4105EDW glycosyl transferase, family 39 Q433_RS06850 ENOG4105CKK Glycosyl transferase, family 2 Q433_RS06860 ENOG4105C0H protease Q433_RS06870 ENOG4108ME1 Peptidase M55 D-aminopeptidase Q433_RS06875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Q433_RS06880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Q433_RS06885 ENOG4105C3U ABC transporter Q433_RS06895 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Q433_RS06900 ENOG4105DTQ mandelate racemase muconate lactonizing Q433_RS06905 ENOG4107SN7 NLP P60 protein Q433_RS06910 ENOG4108JQ7 (ABC) transporter Q433_RS06915 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Q433_RS06920 ENOG4107TUM Amidinotransferase Q433_RS06925 ENOG4108S4H thioesterase Superfamily protein Q433_RS06930 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Q433_RS06950 ENOG4108428 Inherit from COG: -acetyltransferase Q433_RS06960 ENOG41080TC multidrug resistance protein Q433_RS06965 ENOG4105CIY formyltetrahydrofolate deformylase Q433_RS06970 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Q433_RS06985 ENOG4105K56 Transcriptional regulator Q433_RS06990 ENOG4108ZHJ Organic hydroperoxide resistance protein Q433_RS07000 ENOG4107Y2X deaminase Q433_RS07005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Q433_RS07010 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS07020 ENOG4108W7F transporter, permease Q433_RS07025 ENOG4108JJB ABC transporter Q433_RS07030 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Q433_RS07035 ENOG4108X43 YKOF domain protein Q433_RS07040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Q433_RS07045 ENOG41062D9 Histidine kinase Q433_RS07055 ENOG4106849 propeptide, pepSY amd peptidase M4 Q433_RS07075 ENOG4105CJW magnesium transporter Q433_RS07080 ENOG4105V75 Transcriptional regulator Q433_RS07125 ENOG4105DQE DNA ligase Q433_RS07130 ENOG4105FDF Could be involved in DNA repair (By similarity) Q433_RS07135 ENOG4105BZU Histidine kinase Q433_RS07140 ENOG4107T5V SNARE associated Golgi Q433_RS07145 ENOG4107TS3 membrane protein, TerC Q433_RS07150 ENOG4108WZW RNA polymerase sigma Q433_RS07160 ENOG410681C small acid-soluble spore protein Q433_RS07170 ENOG4105D0M Protease HtpX homolog Q433_RS07190 ENOG4108TGC Acyltransferase Q433_RS07195 ENOG4105BZU Histidine kinase Q433_RS07200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Q433_RS07210 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Q433_RS07215 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) Q433_RS07220 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Q433_RS07230 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit Q433_RS07235 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) Q433_RS07240 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Q433_RS07245 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Q433_RS07265 ENOG4105BZU Histidine kinase Q433_RS07270 ENOG41090MY MarR family Transcriptional regulator Q433_RS07275 ENOG4105ER2 Ompa motb domain protein Q433_RS07280 ENOG4105E14 MotA TolQ exbB proton channel Q433_RS07290 ENOG4108K88 Membrane Q433_RS07295 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Q433_RS07300 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase Q433_RS07305 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Q433_RS07310 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Q433_RS07320 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr Q433_RS07325 ENOG4105FEA Spore maturation protein Q433_RS07360 ENOG4105F0V Cell wall hydrolase Q433_RS07375 ENOG4105C59 p-type ATPase Q433_RS07385 ENOG4105DC7 peptidase M24 Q433_RS07400 ENOG4105CID antiterminator Q433_RS07410 ENOG4105KRI phosphocarrier protein (HPr Q433_RS07415 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Q433_RS07425 ENOG4105F6S Spore photoproduct lyase Q433_RS07435 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Q433_RS07440 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Q433_RS07445 ENOG4105K4I Scp-like extracellular Q433_RS07455 ENOG4105BZU Histidine kinase Q433_RS07460 ENOG4105CHM Aminotransferase Q433_RS07470 ENOG4107R88 Chemotaxis protein (CheV) Q433_RS07475 ENOG4105UIN Q433_RS07485 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein Q433_RS07495 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Q433_RS07500 ENOG4105EPM Diguanylate phosphodiesterase Q433_RS07510 ENOG4107IN1 Protein of unknown function (DUF1797) Q433_RS07515 ENOG4108XRC Protein of unknown function (DUF458) Q433_RS07545 ENOG4105NQC Flavodoxin Q433_RS07555 ENOG4105CH2 amidohydrolase Q433_RS07565 ENOG4105D8X mechanosensitive ion channel Q433_RS07570 ENOG4105D3R alkyl hydroperoxide reductase Q433_RS07575 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Q433_RS07590 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Q433_RS07595 ENOG4105D06 uba thif-type nad fad binding protein Q433_RS07600 ENOG4105CVM Molybdenum cofactor synthesis domain protein Q433_RS07605 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein Q433_RS07610 ENOG4108ZAF Molybdopterin Q433_RS07615 ENOG41067WU Molybdopterin converting factor (Subunit 1) Q433_RS07620 ENOG4105BZ1 (ABC) transporter Q433_RS07625 ENOG4105BZ1 (ABC) transporter Q433_RS07635 ENOG4107X8C Efflux transporter RND family MFP subunit Q433_RS07640 ENOG4105C19 ABC transporter Q433_RS07645 ENOG4107RBB ABC transporter, permease Q433_RS07650 ENOG4105E98 transcriptional regulator DeoR family Q433_RS07655 ENOG4105DE4 1-phosphofructokinase Q433_RS07660 ENOG4105DM4 PTS System Q433_RS07665 ENOG4105C3F Signal peptidase i Q433_RS07675 ENOG4105C5H ABC transporter Q433_RS07680 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Q433_RS07705 ENOG4105BZU Histidine kinase Q433_RS07715 ENOG4107ZYR domain protein Q433_RS07725 ENOG4105CN5 Metallo-Beta-Lactamase Q433_RS07735 ENOG4108X4Q Hydrolase Q433_RS07740 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Q433_RS07760 ENOG4105CPP Dehydrogenase, E1 component Q433_RS07765 ENOG4105C7S Dehydrogenase Q433_RS07770 ENOG4107QN2 dihydrolipoyl dehydrogenase Q433_RS07780 ENOG4105CXN decarboxylase Q433_RS07785 ENOG4105WBI UPF0223 protein Q433_RS07800 ENOG4105ECY inositol monophosphatase Q433_RS07810 ENOG4105JQZ Methyltransferase Q433_RS07850 ENOG4105CI3 gtp-binding protein typa Q433_RS07855 ENOG4105QA2 Q433_RS07870 ENOG4108IAB Phoh family Q433_RS07880 ENOG4105CSV Glutaminase Q433_RS07885 ENOG4105ZPI UPF0358 protein Q433_RS07890 ENOG4105CNI cell division protein FtsW Q433_RS07895 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Q433_RS07905 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Q433_RS07915 ENOG4105BZ9 Cytochrome C oxidase, subunit I Q433_RS07920 ENOG4105CCU oxidase (Subunit III) Q433_RS07925 ENOG41064X9 cytochrome C oxidase subunit IV Q433_RS07940 ENOG41080XQ Signal transduction protein with cbs domains Q433_RS07945 ENOG4106UY4 Inherit from COG: Scp-like extracellular Q433_RS07965 ENOG4105WUC UPF0298 protein Q433_RS07970 ENOG4106H78 methyltransferase Q433_RS07975 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Q433_RS07980 ENOG4105H20 Sporulation integral membrane protein YlbJ Q433_RS07985 ENOG4105D78 K07001 NTE family protein Q433_RS07990 ENOG41063PX domain protein Q433_RS07995 ENOG4105CDE UPF0348 protein Q433_RS08005 ENOG4105KNH Nucleic acid-binding protein Q433_RS08035 ENOG4108V6E Cell division protein mraZ Q433_RS08040 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Q433_RS08050 ENOG4105CJN penicillin-binding protein Q433_RS08060 ENOG4105CJN penicillin-binding protein Q433_RS08070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Q433_RS08080 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Q433_RS08085 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Q433_RS08090 ENOG4105CNI cell division protein FtsW Q433_RS08095 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Q433_RS08100 ENOG4105D4A Cell wall formation (By similarity) Q433_RS08105 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) Q433_RS08110 ENOG4108R2U division initiation protein Q433_RS08120 ENOG4105K67 small basic protein Q433_RS08125 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Q433_RS08130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Q433_RS08140 ENOG4105FFI sigma-e processing peptidase spoiiga Q433_RS08145 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS08155 ENOG4105DKW ABC transporter Q433_RS08165 ENOG4105WR5 sporulation protein, YlmC YmxH family Q433_RS08170 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Q433_RS08175 ENOG4105DFA alanine racemase domain protein Q433_RS08180 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Q433_RS08185 ENOG41067XK integral membrane protein Q433_RS08190 ENOG4105DBK s4 domain protein Q433_RS08200 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Q433_RS08210 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Q433_RS08215 ENOG4105C34 Pseudouridine synthase Q433_RS08220 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Q433_RS08230 ENOG4105CXT aspartate transcarbamylase Q433_RS08240 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Q433_RS08245 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Q433_RS08250 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Q433_RS08255 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) Q433_RS08260 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Q433_RS08265 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Q433_RS08275 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Q433_RS08285 ENOG4107S4M Sulfate adenylate transferase Q433_RS08290 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Q433_RS08295 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Q433_RS08300 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein Q433_RS08305 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein Q433_RS08320 ENOG4105DSJ YicC domain protein Q433_RS08325 ENOG4105KC4 UPF0296 protein Q433_RS08330 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Q433_RS08340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Q433_RS08345 ENOG4105C25 Primosomal protein n' Q433_RS08350 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Q433_RS08355 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Q433_RS08360 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Q433_RS08365 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Q433_RS08370 ENOG4108ZF3 Phosphatase Q433_RS08375 ENOG4105D9P serine threonine protein kinase Q433_RS08380 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Q433_RS08385 ENOG4105DJV ribulose-phosphate 3-epimerase Q433_RS08390 ENOG4105FJ0 thiamine Q433_RS08400 ENOG4105VB9 50S ribosomal protein l28 Q433_RS08405 ENOG4108ZAA Alkaline-shock protein Q433_RS08410 ENOG4105DP4 dak2 domain fusion protein ylov Q433_RS08420 ENOG4105EJQ L-serine dehydratase Q433_RS08425 ENOG4105CB5 ATP-dependent DNA helicase recG Q433_RS08430 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) Q433_RS08440 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Q433_RS08445 ENOG4105CHR reductase Q433_RS08455 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Q433_RS08460 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Q433_RS08465 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Q433_RS08475 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) Q433_RS08485 ENOG4105K5M 30s ribosomal protein S16 Q433_RS08490 ENOG4108BW8 UPF0109 protein Q433_RS08500 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Q433_RS08505 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Q433_RS08510 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Q433_RS08515 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Q433_RS08520 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Q433_RS08530 ENOG4105VM1 flagellar Q433_RS08535 ENOG4105CMV Succinyl-CoA synthetase subunit beta Q433_RS08540 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Q433_RS08545 ENOG4105C79 DNA protecting protein DprA Q433_RS08550 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Q433_RS08555 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Q433_RS08560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Q433_RS08565 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Q433_RS08570 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Q433_RS08580 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Q433_RS08585 ENOG4108ZC9 flagellar basal-body rod protein flgc Q433_RS08590 ENOG4105VQ0 flagellar hook-basal body complex protein fliE Q433_RS08595 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Q433_RS08600 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Q433_RS08615 ENOG4106YF4 Flagellar biosynthesis chaperone Q433_RS08625 ENOG410696Y Flagellar hook-length control protein Q433_RS08630 ENOG410822I Flagellar hook capping protein Q433_RS08635 ENOG4108JQA flagellar Q433_RS08640 ENOG41068WV flagellar FlbD family protein Q433_RS08650 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Q433_RS08655 ENOG4105DD5 Flagellar motor switch protein Q433_RS08660 ENOG4107YTP response regulator receiver protein Q433_RS08670 ENOG4105CN7 Flagellar biosynthetic protein FliP Q433_RS08675 ENOG4105VS8 Flagellar biosynthetic protein fliq Q433_RS08680 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Q433_RS08685 ENOG4105D00 flagellar biosynthetic protein flhB Q433_RS08690 ENOG4105D7B Flagellar biosynthesis protein flha Q433_RS08695 ENOG4105FZW flagellar biosynthesis regulator FlhF Q433_RS08705 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Q433_RS08710 ENOG4105CBS Chea signal transduction histidine kinase Q433_RS08715 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis Q433_RS08730 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS08740 ENOG4105CE9 30S ribosomal protein S2 Q433_RS08745 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Q433_RS08755 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Q433_RS08760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Q433_RS08765 ENOG4105KNE Phosphatidate cytidylyltransferase Q433_RS08775 ENOG4105DZP Membrane-associated zinc metalloprotease Q433_RS08780 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Q433_RS08785 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Q433_RS08790 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Q433_RS08795 ENOG4105CHV Transcription elongation factor NusA Q433_RS08800 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Q433_RS08805 ENOG4105VHM ribosomal protein Q433_RS08810 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Q433_RS08815 ENOG4105W7A Protein of unknown function (DUF503) Q433_RS08820 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Q433_RS08825 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Q433_RS08830 ENOG4105DTN riboflavin biosynthesis protein ribF Q433_RS08835 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Q433_RS08840 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Q433_RS08850 ENOG4105C1V Peptidase, M16 Q433_RS08865 ENOG4105E35 Dipicolinate synthase subunit A Q433_RS08870 ENOG4108S0H Dipicolinic acid synthetase, b subunit Q433_RS08875 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Q433_RS08885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Q433_RS08895 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Q433_RS08905 ENOG4105CNU cell division protein FtsK Q433_RS08910 ENOG4105FDP GntR family transcriptional regulator Q433_RS08930 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Q433_RS08935 ENOG4105XZV Protein of unknown function (DUF3243) Q433_RS08950 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Q433_RS08955 ENOG4105CEV competence damage-inducible protein Q433_RS08965 ENOG4108A04 Beta-lactamase Q433_RS08970 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Q433_RS08975 ENOG4105D48 metallophosphoesterase Q433_RS08980 ENOG4105MCT stage V sporulation protein S Q433_RS08990 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Q433_RS08995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Q433_RS09010 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Q433_RS09015 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Q433_RS09030 ENOG4105IIP Membrane Q433_RS09035 ENOG4105W1N transcriptional regulator Q433_RS09040 ENOG4108151 Beta-lactamase domain protein Q433_RS09050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Q433_RS09060 ENOG4107QKG PfaD family Q433_RS09065 ENOG41062T2 Acyl carrier protein Q433_RS09070 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase Q433_RS09075 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase Q433_RS09080 ENOG4108MGH Enoyl-CoA hydratase Q433_RS09085 ENOG4108KQ6 Enoyl-CoA hydratase Q433_RS09090 ENOG4105C0W non-ribosomal peptide synthetase Q433_RS09095 ENOG4107SQU synthase Q433_RS09105 ENOG4105C0W non-ribosomal peptide synthetase Q433_RS09115 ENOG4106A3M Cytochrome p-450 Q433_RS09130 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS09140 ENOG4105K7W phage-related replication protein Q433_RS09145 ENOG4108X3M OsmC Ohr family protein Q433_RS09150 ENOG410814C multidrug resistance protein Q433_RS09170 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Q433_RS09175 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Q433_RS09190 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Q433_RS09195 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Q433_RS09200 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Q433_RS09205 ENOG4105U6W MutT NUDIX family protein Q433_RS09210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Q433_RS09215 ENOG4106F1P AAA ATPase, central domain protein Q433_RS09225 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Q433_RS09230 ENOG4105CXI aluminum resistance protein Q433_RS09235 ENOG4105KV4 Transcriptional regulator Q433_RS09240 ENOG4105C5F glutamine synthetase Q433_RS09245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Q433_RS09255 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase Q433_RS09335 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin Q433_RS09425 ENOG4108FKH Transglycosylase SLT domain Q433_RS09435 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Q433_RS09440 ENOG410651K Teichoic acid biosynthesis protein C Q433_RS09450 ENOG41068G1 Q433_RS09470 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase Q433_RS09480 ENOG4106BHF Q433_RS09490 ENOG41079P0 Q433_RS09525 ENOG4106WTF Glycosyl transferase, family 2 Q433_RS09530 ENOG4107RGC Glycosyl transferase, family 2 Q433_RS09560 ENOG4107NTZ Q433_RS09575 ENOG410907G Q433_RS09585 ENOG4105CT4 transporter Q433_RS09590 ENOG4105DSG hydrolase family 43 Q433_RS09595 ENOG4105E2R ROK family Q433_RS09600 ENOG4105C93 Xylose Isomerase Q433_RS09605 ENOG4105CMG Carbohydrate kinase Q433_RS09610 ENOG4107Y9E nuclease Q433_RS09615 ENOG4105C54 Major Facilitator superfamily Q433_RS09620 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Q433_RS09630 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Q433_RS09705 ENOG4108NHD germination protein Q433_RS09720 ENOG4105FVX Q433_RS09730 ENOG4105K7W phage-related replication protein Q433_RS09740 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) Q433_RS09750 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Q433_RS09760 ENOG4108SVB resolvase Q433_RS09765 ENOG4105VPS UPF0291 protein Q433_RS09770 ENOG4105CV1 Transketolase (EC 2.2.1.1) Q433_RS09790 ENOG4107QIV Cytochrome c biogenesis protein Q433_RS09815 ENOG4107DZX Small, acid-soluble spore protein P Q433_RS09825 ENOG4108I0Z Aconitate hydratase Q433_RS09830 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Q433_RS09845 ENOG41067CD Small, acid-soluble spore protein Tlp Q433_RS09855 ENOG4105MI2 Q433_RS09860 ENOG4105W8X HesB YadR YfhF-family protein Q433_RS09865 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Q433_RS09870 ENOG4105K4P CoA-binding domain protein Q433_RS09875 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Q433_RS09900 ENOG4107QWR cellulase (EC 3.2.1.4) Q433_RS09910 ENOG4108MYR Secreted protein Q433_RS09915 ENOG4107SYN Glycosyl hydrolases family 43 Q433_RS09930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Q433_RS09935 ENOG4107T5V SNARE associated Golgi Q433_RS09945 ENOG4107QX3 carboxylase Q433_RS09950 ENOG4105E39 Enoyl-CoA hydratase Q433_RS09955 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Q433_RS09960 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Q433_RS09965 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Q433_RS09970 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS09975 ENOG4105C1G acyl-Coa dehydrogenase Q433_RS09990 ENOG4105F32 YngK protein Q433_RS09995 ENOG4106U2H Protein of unknown function (DUF1360) Q433_RS10005 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS10020 ENOG4105C0W non-ribosomal peptide synthetase Q433_RS10025 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family Q433_RS10030 ENOG4108N2V aldose 1-epimerase Q433_RS10035 ENOG4107QJQ Mate efflux family protein Q433_RS10060 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Q433_RS10065 ENOG4105SKE transcriptional Regulator LysR family Q433_RS10070 ENOG4105CB2 alcohol dehydrogenase Q433_RS10075 ENOG4105BZ8 glutamate synthase Q433_RS10080 ENOG4105CBC glutamate synthase Q433_RS10085 ENOG4105C5Q Transcriptional regulator Q433_RS10090 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Q433_RS10095 ENOG4105II7 pyrroline-5-carboxylate reductase Q433_RS10115 ENOG4108UB7 Q433_RS10120 ENOG41068WN Q433_RS10140 ENOG4105IE8 Alpha-ketoglutarate permease Q433_RS10145 ENOG4107U6E carbohydrate kinase FGGY Q433_RS10150 ENOG4108M3J Dehydrogenase Q433_RS10155 ENOG4108J2R molybdopterin oxidoreductase Q433_RS10180 ENOG4105EC8 Methyl-accepting chemotaxis Q433_RS10190 ENOG4108YQE rare lipoprotein a Q433_RS10195 ENOG4105XPP Protein of unknown function (DUF1275) Q433_RS10200 ENOG4108NR7 pectate lyase Q433_RS10205 ENOG4108RAV Conserved protein Q433_RS10215 ENOG4105F0F Oxalate decarboxylase Q433_RS10225 ENOG4105EPI acetyltransferase, (GNAT) family Q433_RS10245 ENOG41073R8 VanW family Q433_RS10255 ENOG4105VMP Transcriptional regulator Q433_RS10260 ENOG4105NX3 Membrane Q433_RS10270 ENOG4108Q5Y Membrane Q433_RS10280 ENOG4108V4B ThiJ pfpI Q433_RS10285 ENOG4108J4B Beta-lactamase Q433_RS10305 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Q433_RS10310 ENOG4107T94 Endo-14-beta-xylanase Q433_RS10320 ENOG4105YB8 TM2 domain containing protein Q433_RS10325 ENOG4108IMY Transcriptional regulator Q433_RS10430 ENOG410780I phosphoprotein phosphatase activity Q433_RS10475 ENOG4108Z7R Chaperone CsaA Q433_RS10480 ENOG4105FTV AraC Family Transcriptional Regulator Q433_RS10485 ENOG4108HJF gCN5-related N-acetyltransferase Q433_RS10495 ENOG4108W8B Beta-lactamase domain protein Q433_RS10505 ENOG4105D29 Helix-turn-helix type 11 domain protein Q433_RS10515 ENOG4105KTU Transcriptional regulator, arsr family Q433_RS10525 ENOG4108SJC Membrane Q433_RS10545 ENOG4105ECK Fatty Acid Desaturase Q433_RS10550 ENOG4108ZGX Histidine kinase Q433_RS10555 ENOG4108S01 response regulator Q433_RS10565 ENOG41069ER domain protein Q433_RS10570 ENOG4105C9U ATP-dependent DNA helicase RecQ Q433_RS10580 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Q433_RS10585 ENOG4105SCY DNAK suppressor Q433_RS10625 ENOG4105C26 Dehydrogenase Q433_RS10630 ENOG4105EWU Squalene--hopene cyclase Q433_RS10635 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Q433_RS10640 ENOG4105C8J )-transporter Q433_RS10645 ENOG4105C09 Bile acid Q433_RS10650 ENOG4105C7S Dehydrogenase Q433_RS10660 ENOG4107T89 von Willebrand factor, type A Q433_RS10665 ENOG4105GMT ATPase associated with various cellular activities aaa_5 Q433_RS10675 ENOG4105K4H Nlp p60 protein Q433_RS10680 ENOG41087PP glycosyltransferase MGT family Q433_RS10690 ENOG4107QMU Mate efflux family protein Q433_RS10695 ENOG4106SCS STAS domain Q433_RS10715 ENOG4105FR1 rard protein Q433_RS10730 ENOG4105C6Z Gluconate Q433_RS10735 ENOG41090U3 tautomerase Q433_RS10750 ENOG4105FBA Phospholipase Carboxylesterase Q433_RS10765 ENOG4105E1V na solute symporter Q433_RS10785 ENOG4108VXD carboxy-peptidase Q433_RS10790 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Q433_RS10800 ENOG4106Z5R Q433_RS10805 ENOG410841Q phosphoesterase PA-phosphatase related protein Q433_RS10840 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Q433_RS10850 ENOG4107S4Y M20 DapE family protein YgeY Q433_RS10865 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Q433_RS10905 ENOG4107T32 3-phytase (EC 3.1.3.8) Q433_RS10915 ENOG4105C5E polysaccharide biosynthesis protein Q433_RS10920 ENOG4105E0X reductase Q433_RS10925 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Q433_RS10945 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) Q433_RS10950 ENOG41090WU lipolytic protein G-D-S-L family Q433_RS10955 ENOG4108KF3 Electron transport protein SCO1 SenC Q433_RS10970 ENOG4105C7B Threonine dehydratase Q433_RS10980 ENOG4108UT2 hemolysin iii Q433_RS10990 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Q433_RS10995 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Q433_RS11010 ENOG4107YX5 Pfam:DUF548 Q433_RS11015 ENOG4108Y6J UPF0403 protein Q433_RS11020 ENOG4105C01 Dihydroxy-acid dehydratase Q433_RS11035 ENOG4108V06 Glutathione peroxidase Q433_RS11040 ENOG4105CVG Homoserine O-transsuccinylase Q433_RS11080 ENOG41081VK Ribonuclease Q433_RS11110 ENOG410890F Dynamin family Q433_RS11120 ENOG41065KQ synthase Q433_RS11125 ENOG4105C2W permease Q433_RS11130 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) Q433_RS11135 ENOG4105CTD carboxy-peptidase Q433_RS11140 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) Q433_RS11145 ENOG4108UHU Aldolase Q433_RS11150 ENOG4105D7K pfkb domain protein Q433_RS11155 ENOG4108M60 Transcriptional regulator Q433_RS11165 ENOG4105CHR reductase Q433_RS11170 ENOG4105DVT helicase Q433_RS11180 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Q433_RS11190 ENOG4108UKS UPF0398 protein Q433_RS11200 ENOG4107X2U Inherit from COG: Exonuclease-like protein Q433_RS11205 ENOG4108I5C dEAD DEAH box helicase Q433_RS11255 ENOG4105BZ4 penicillin-binding protein Q433_RS11265 ENOG4105CSM endonuclease III Q433_RS11275 ENOG4105C5S asparaginyl-tRNA synthetase Q433_RS11280 ENOG4105CHM Aminotransferase Q433_RS11290 ENOG4105YAC Q433_RS11295 ENOG4105DVT helicase Q433_RS11300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Q433_RS11305 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Q433_RS11310 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Q433_RS11315 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Q433_RS11320 ENOG4105DJ0 Poly(A) Polymerase Q433_RS11325 ENOG4105CPK Glycosyl transferase (Group 1 Q433_RS11330 ENOG4105FJR Lmbe family Q433_RS11335 ENOG4108Z5K methylglyoxal synthase Q433_RS11340 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Q433_RS11345 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase Q433_RS11350 ENOG4108JYZ YitT family Q433_RS11370 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Q433_RS11390 ENOG41068YB TPR repeat-containing protein Q433_RS11395 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Q433_RS11405 ENOG4105CIH Imidazole acetol-phosphate transaminase Q433_RS11415 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Q433_RS11420 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Q433_RS11430 ENOG4108I0Q anthranilate phosphoribosyltransferase Q433_RS11435 ENOG4105CRQ synthase (Component I) Q433_RS11440 ENOG4105KHN chorismate mutase Q433_RS11445 ENOG4105D49 3-dehydroquinate synthase Q433_RS11450 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Q433_RS11455 ENOG4105BZU Histidine kinase Q433_RS11465 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Q433_RS11470 ENOG4105EAH synthase Q433_RS11475 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Q433_RS11480 ENOG4105XXQ heptaprenyl diphosphate synthase component I Q433_RS11490 ENOG4105EUJ GTP cyclohydrolase i Q433_RS11495 ENOG4105K70 DNA-binding protein Q433_RS11500 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Q433_RS11515 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Q433_RS11520 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Q433_RS11525 ENOG41065D1 Q433_RS11530 ENOG4105S2F Q433_RS11545 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Q433_RS11550 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Q433_RS11555 ENOG4105CAT Cytidine monophosphate kinase Q433_RS11570 ENOG4105MSI germination protein ypeb Q433_RS11580 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) Q433_RS11585 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase Q433_RS11600 ENOG4107RGJ metallophosphoesterase Q433_RS11615 ENOG4105I7S Abortive infection protein Q433_RS11620 ENOG4105C9U ATP-dependent DNA helicase RecQ Q433_RS11625 ENOG4105T7X Q433_RS11635 ENOG4108SAX Membrane Q433_RS11645 ENOG4108JQ1 Dehydrogenase Q433_RS11650 ENOG4105FF2 Type I DHQase Q433_RS11665 ENOG4105BZU Histidine kinase Q433_RS11670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Q433_RS11675 ENOG4105CRE cytochrome C Q433_RS11680 ENOG4107TWT Cytochrome c biogenesis protein Q433_RS11690 ENOG4105FE9 pseudouridine synthase Q433_RS11700 ENOG4108JIC nucleoside recognition domain protein Q433_RS11705 ENOG4105DZ1 carboxypeptidase Q433_RS11715 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Q433_RS11720 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Q433_RS11735 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Q433_RS11740 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Q433_RS11745 ENOG4108R6K riboflavin synthase, subunit alpha Q433_RS11750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Q433_RS11760 ENOG4105C3F Signal peptidase i Q433_RS11765 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Q433_RS11785 ENOG4107ZE5 PPIases accelerate the folding of proteins Q433_RS11790 ENOG4105PTM secreted protein Q433_RS11795 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Q433_RS11805 ENOG4105G6R Stage v sporulation protein ae Q433_RS11815 ENOG4105CZ3 stage V sporulation protein ad Q433_RS11820 ENOG41090VF Stage v sporulation protein ac Q433_RS11835 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS11840 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Q433_RS11845 ENOG41082AN stage II sporulation protein Q433_RS11850 ENOG4105DZ1 carboxypeptidase Q433_RS11855 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) Q433_RS11860 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) Q433_RS11865 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Q433_RS11875 ENOG4105I3K Ferric uptake regulator, Fur family Q433_RS11880 ENOG4105MZ9 stage II sporulation protein m Q433_RS11895 ENOG4105DFD Na H antiporter Q433_RS11900 ENOG4108IJ0 Aspartate ammonia-lyase Q433_RS11905 ENOG4105HDK L-asparaginase Q433_RS11910 ENOG4108IMY Transcriptional regulator Q433_RS11920 ENOG4108YZ4 nudix hydrolase Q433_RS11930 ENOG4105CPC Aldo Keto reductase Q433_RS11950 ENOG4106HZJ Q433_RS11955 ENOG4105RHY Pfam:UPF0157 Q433_RS11960 ENOG4105KAC Antibiotic biosynthesis monooxygenase Q433_RS11965 ENOG4108XET gCN5-related N-acetyltransferase Q433_RS11975 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Q433_RS11985 ENOG4105E5W Transporter Q433_RS11995 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS12010 ENOG4108IXY short-chain dehydrogenase reductase Q433_RS12015 ENOG41069FQ Metallo-beta-lactamase superfamily Q433_RS12020 ENOG4105II7 pyrroline-5-carboxylate reductase Q433_RS12030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Q433_RS12040 ENOG410861F 50S ribosomal protein L33 Q433_RS12045 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Q433_RS12050 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Q433_RS12055 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Q433_RS12060 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Q433_RS12070 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) Q433_RS12075 ENOG4108NA0 Uncharacterized conserved protein (COG2071) Q433_RS12080 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Q433_RS12085 ENOG4108HNZ carboxyl transferase Q433_RS12090 ENOG4108ZVT methylmalonyl-coA epimerase Q433_RS12100 ENOG4108VZI ErfK ybiS ycfS ynhG family protein Q433_RS12105 ENOG4108QEG Membrane Q433_RS12110 ENOG4105CDA abc transporter atp-binding protein Q433_RS12115 ENOG4105E5Q amino acid AbC transporter Q433_RS12120 ENOG4108HW3 (ABC) transporter Q433_RS12125 ENOG4108Y6J UPF0403 protein Q433_RS12130 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) Q433_RS12145 ENOG4105C7S Dehydrogenase Q433_RS12150 ENOG4105CPP Dehydrogenase, E1 component Q433_RS12165 ENOG4105CKM Branched-chain carboxylic acid kinase Q433_RS12170 ENOG4107RDP Dehydrogenase Q433_RS12180 ENOG4108JUB Transcriptional regulator Q433_RS12185 ENOG4106CCJ Protein of unknown function (DUF2627) Q433_RS12190 ENOG4105CR4 methylisocitrate lyase Q433_RS12195 ENOG4105DXD 2-methylcitrate dehydratase Q433_RS12205 ENOG4105C1G acyl-Coa dehydrogenase Q433_RS12210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Q433_RS12220 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Q433_RS12225 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Q433_RS12240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Q433_RS12250 ENOG4107QQR Sporulation Q433_RS12260 ENOG4105S1Z Stage IV sporulation protein B Q433_RS12265 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Q433_RS12270 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Q433_RS12275 ENOG4105DX0 Hemolysin A Q433_RS12285 ENOG4105CTB Polyprenyl synthetase Q433_RS12290 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Q433_RS12295 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Q433_RS12300 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Q433_RS12305 ENOG4105M7K Involved in the transcription termination process (By similarity) Q433_RS12310 ENOG4108ZSR alkaline shock protein Q433_RS12315 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Q433_RS12335 ENOG410644B Stage III sporulation protein af Q433_RS12345 ENOG4105KQ4 Stage iii sporulation protein ad Q433_RS12350 ENOG4108CQH stage III sporulation protein AC Q433_RS12355 ENOG4105KR5 Stage iii sporulation protein Q433_RS12360 ENOG4105CD2 stage iii sporulation protein aa Q433_RS12370 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Q433_RS12375 ENOG4105DC7 peptidase M24 Q433_RS12380 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Q433_RS12390 ENOG4105CBJ Metal-dependent enzyme Q433_RS12405 ENOG4105KST dependent repressor Q433_RS12410 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) Q433_RS12415 ENOG4105WZW rhodanese family Q433_RS12420 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Q433_RS12425 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Q433_RS12430 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Q433_RS12435 ENOG4105C0D helicase Q433_RS12450 ENOG4108IMY Transcriptional regulator Q433_RS12460 ENOG4105VFR signal peptidase Q433_RS12520 ENOG41080XP Cbs domain Q433_RS12530 ENOG4105C37 (CBS) domain Q433_RS12580 ENOG4105E0M Sulfatase Q433_RS12595 ENOG4107ZXI Rhomboid family Q433_RS12605 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Q433_RS12630 ENOG41068DG YceG-like family Q433_RS12635 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Q433_RS12640 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Q433_RS12645 ENOG4105E2Z phosphate ABC transporter (Permease Q433_RS12650 ENOG4105C8U phosphate abc transporter Q433_RS12655 ENOG4105CVA phosphate Q433_RS12660 ENOG4107RF6 penicillin-binding protein Q433_RS12670 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Q433_RS12675 ENOG4105SXS Protein of unknown function (DUF456) Q433_RS12690 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Q433_RS12695 ENOG41063Y9 Q433_RS12700 ENOG4108U5J '-nucleotidase Q433_RS12705 ENOG4105N80 Ferric uptake regulator, Fur family Q433_RS12710 ENOG4108JYZ YitT family Q433_RS12715 ENOG41069ZM Protein of unknown function (DUF2624) Q433_RS12720 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Q433_RS12735 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Q433_RS12740 ENOG4105EGD dinuclear metal center protein, YbgI family Q433_RS12755 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS12760 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Q433_RS12765 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 Q433_RS12770 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Q433_RS12780 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Q433_RS12785 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Q433_RS12790 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Q433_RS12800 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Q433_RS12805 ENOG4105KG3 cytidine deaminase Q433_RS12810 ENOG4107YR5 Diacylglycerol kinase Q433_RS12815 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Q433_RS12820 ENOG4105CTJ Metal Dependent Phosphohydrolase Q433_RS12830 ENOG4105C9A Phoh family Q433_RS12835 ENOG4105EI1 sporulation protein yqfd Q433_RS12840 ENOG41068P3 sporulation protein YqfC Q433_RS12850 ENOG4105DI5 UPF0365 protein Q433_RS12855 ENOG4105F7J membrane-bound serine protease Q433_RS12860 ENOG4105KTH gatB Yqey Q433_RS12875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Q433_RS12880 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Q433_RS12885 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Q433_RS12895 ENOG4105CFG Acts as a chaperone (By similarity) Q433_RS12900 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Q433_RS12905 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Q433_RS12910 ENOG4105CSA Coproporphyrinogen iii oxidase Q433_RS12915 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Q433_RS12925 ENOG4108ZRV stage ii sporulation protein p Q433_RS12930 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) Q433_RS12935 ENOG41082YS Binds directly to 16S ribosomal RNA Q433_RS12940 ENOG4105TQK DNA polymerase iii, delta' subunit Q433_RS12950 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Q433_RS12955 ENOG4108UK2 deaminase Q433_RS12960 ENOG4105KQC Competence protein Q433_RS12970 ENOG4108D32 Methyltransferase Q433_RS12980 ENOG4108WF2 Metal Dependent Phosphohydrolase Q433_RS12985 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Q433_RS12990 ENOG410812S Rna-binding protein Q433_RS12995 ENOG4105E2X shikimate dehydrogenase Q433_RS13000 ENOG4105CQW ribosome biogenesis GTPase YqeH Q433_RS13005 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Q433_RS13025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Q433_RS13030 ENOG41080BT SNARE associated Golgi Q433_RS13045 ENOG4105WFK nuclease Q433_RS13050 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS13060 ENOG4108SWU Histidine kinase Q433_RS13065 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Q433_RS13070 ENOG4105DHF Membrane Q433_RS13080 ENOG4108UYN gCN5-related N-acetyltransferase Q433_RS13085 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Q433_RS13090 ENOG41068VA Q433_RS13095 ENOG41087NI Sulfite exporter TauE/SafE Q433_RS13100 ENOG4105VFE sira family Q433_RS13105 ENOG4107TPS domain protein Q433_RS13115 ENOG4105VFE sira family Q433_RS13125 ENOG4105XTG Pfam:DUF156 Q433_RS13130 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein Q433_RS13145 ENOG41090E6 transcriptional regulator MERR family Q433_RS13160 ENOG4105C37 (CBS) domain Q433_RS13175 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family Q433_RS13180 ENOG4105H3G oxidoreductase Q433_RS13185 ENOG4105PGM cation diffusion facilitator family transporter Q433_RS13190 ENOG41090U3 tautomerase Q433_RS13210 ENOG4105KMT branched-chain amino acid Q433_RS13215 ENOG4108UMN azlc family Q433_RS13220 ENOG4108ZRZ Transcriptional regulator (AsnC family) Q433_RS13250 ENOG41064BW Protein of unknown function (DUF2568) Q433_RS13260 ENOG41075D4 Aminoglycoside 6-adenylyltransferase Q433_RS13265 ENOG4105EA8 2-Nitropropane dioxygenase Q433_RS13270 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Q433_RS13280 ENOG4107YCY Transcriptional regulator Q433_RS13290 ENOG4105CHR reductase Q433_RS13295 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Q433_RS13300 ENOG4108HHA Transketolase Q433_RS13315 ENOG4105UNS Pfam:DUF419 Q433_RS13325 ENOG4108MEK Metal-binding protein YodA Q433_RS13330 ENOG410904A RNA polymerase Q433_RS13335 ENOG4105CPC Aldo Keto reductase Q433_RS13345 ENOG4108KAM Transcriptional regulator Q433_RS13350 ENOG4105C7F AcnD-accessory protein PrpF Q433_RS13355 ENOG41083Q9 chitosanase Q433_RS13360 ENOG4105X5K response regulator receiver protein Q433_RS13365 ENOG4108VQT Alpha beta hydrolase fold protein Q433_RS13370 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein Q433_RS13375 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein Q433_RS13380 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS13390 ENOG4105PGS Spore coat protein Q433_RS13395 ENOG4105E2A Dehydrogenase Q433_RS13410 ENOG4105VUF Transcriptional regulator Q433_RS13415 ENOG4105DQ4 alcohol dehydrogenase Q433_RS13420 ENOG4108Z0Z intracellular protease Pfpi family Q433_RS13425 ENOG4108HKT sucrose-6-phosphate hydrolase Q433_RS13430 ENOG4105F3R pts system mannose fructose sorbose family iid Q433_RS13435 ENOG4105ETZ PTS System Q433_RS13440 ENOG4108IQ3 PTS system Q433_RS13445 ENOG4105YHU PTS system Q433_RS13450 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Q433_RS13455 ENOG4105C85 amino acid Q433_RS13460 ENOG4105N14 lysine exporter protein LysE YggA Q433_RS13465 ENOG4108NGU Transcriptional regulator Q433_RS13470 ENOG4105JVQ RNA Polymerase Q433_RS13475 ENOG4108P49 AntiSigma factor Q433_RS13485 ENOG4105WDR Q433_RS13490 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Q433_RS13495 ENOG41082JN Transcriptional regulator Q433_RS13515 ENOG4105TMB Formate nitrite transporter Q433_RS13520 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) Q433_RS13525 ENOG4108JB9 formate dehydrogenase Q433_RS13540 ENOG4105C28 cystathionine Q433_RS13555 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) Q433_RS13570 ENOG4107XRG penicillin-binding protein Q433_RS13575 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Q433_RS13580 ENOG4105DBI uridine monophosphokinase Q433_RS13585 ENOG4105CFP Peptidase U32 Q433_RS13590 ENOG4105XYU peptidase (U32 family) Q433_RS13600 ENOG4105HHA aminodeoxychorismate lyase Q433_RS13605 ENOG4105VPH UPF0473 protein Q433_RS13610 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Q433_RS13615 ENOG4105VBH UPF0297 protein Q433_RS13620 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Q433_RS13625 ENOG4105C02 permease Q433_RS13630 ENOG4105CDA abc transporter atp-binding protein Q433_RS13635 ENOG4105CT1 (ABC) transporter Q433_RS13640 ENOG4105EAD ABC transporter Q433_RS13645 ENOG4105DRP amino acid AbC transporter Q433_RS13655 ENOG41060CR Q433_RS13665 ENOG4105C7H Helicase, RecD TraA family Q433_RS13675 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Q433_RS13680 ENOG4105C3J Cysteine desulfurase Q433_RS13690 ENOG4105D1H recombination factor protein RarA Q433_RS13695 ENOG4105CUZ uba thif-type nad fad binding protein Q433_RS13705 ENOG4105C9M aspartyl-trna synthetase Q433_RS13710 ENOG4105CUT histidyl-tRNA synthetase Q433_RS13720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Q433_RS13730 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Q433_RS13735 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Q433_RS13740 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Q433_RS13745 ENOG41067VP Protein of unknown function (DUF1049) Q433_RS13750 ENOG4105NCW Trka-c domain protein Q433_RS13755 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Q433_RS13765 ENOG4105CKP Polysaccharide Biosynthesis Protein Q433_RS13770 ENOG4108QG2 Membrane Q433_RS13775 ENOG4105NAP Q433_RS13780 ENOG4105VIE preprotein translocase, subunit YajC Q433_RS13785 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Q433_RS13790 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Q433_RS13795 ENOG41061AI Protein of unknown function (DUF2905) Q433_RS13800 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Q433_RS13805 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Q433_RS13815 ENOG4105IE8 Alpha-ketoglutarate permease Q433_RS13820 ENOG4105CK5 oxidoreductase Q433_RS13845 ENOG4105BZG amino acid carrier protein Q433_RS13850 ENOG4105CDY transcriptional regulatory protein Q433_RS13860 ENOG4106678 morphogenetic protein associated with SpoVID Q433_RS13865 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Q433_RS13870 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Q433_RS13875 ENOG4108IYU L-aspartate oxidase Q433_RS13890 ENOG4105CQC Prephenate dehydratase Q433_RS13895 ENOG41090I5 UPF0735 ACT domain-containing protein Q433_RS13900 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Q433_RS13915 ENOG4105K46 50S ribosomal protein l27 Q433_RS13920 ENOG4105X36 (ribosomal) protein Q433_RS13925 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Q433_RS13940 ENOG4107QMS site-determining protein Q433_RS13945 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) Q433_RS13950 ENOG4105YHC Rod shape-determining protein MreD Q433_RS13960 ENOG4105DFF Rod shape-determining protein mreb Q433_RS13965 ENOG4105W5Q DNA repair protein (RadC Q433_RS13970 ENOG4108Z03 MAF-like protein Q433_RS13980 ENOG4106A3R peptidase Q433_RS13985 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Q433_RS13990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Q433_RS14000 ENOG4106AR7 Spore coat protein Q433_RS14005 ENOG41068KH stage VI sporulation protein D Q433_RS14010 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Q433_RS14015 ENOG4105D52 delta-aminolevulinic acid dehydratase Q433_RS14025 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Q433_RS14035 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Q433_RS14045 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Q433_RS14050 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Q433_RS14055 ENOG4108IUQ atp-dependent protease Q433_RS14060 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Q433_RS14065 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Q433_RS14075 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Q433_RS14080 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Q433_RS14085 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Q433_RS14090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Q433_RS14095 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Q433_RS14100 ENOG4108ZP8 Acetolactate synthase small subunit Q433_RS14105 ENOG4105C7K acetolactate synthase Q433_RS14115 ENOG4105I4A GCN5-related N-acetyltransferase Q433_RS14125 ENOG4107KM7 Heat induced stress protein YflT Q433_RS14135 ENOG4105M59 Phosphodiesterase, mj0936 family Q433_RS14140 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Q433_RS14145 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Q433_RS14150 ENOG4108XJQ germination protein Q433_RS14155 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Q433_RS14160 ENOG41067TZ transcriptional regulator, MarR family Q433_RS14165 ENOG4105PFC Transcriptional regulator Q433_RS14175 ENOG4105E33 succinate dehydrogenase Q433_RS14185 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit Q433_RS14200 ENOG4105CFH Aspartokinase Q433_RS14205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Q433_RS14210 ENOG4105K63 Thioredoxin Q433_RS14215 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Q433_RS14220 ENOG4105C10 Electron transfer flavoprotein Q433_RS14225 ENOG4105BZJ Electron transfer flavoprotein Q433_RS14230 ENOG41060WC Enoyl-CoA hydratase Q433_RS14235 ENOG4107Z3H Transcriptional regulator, TetR family Q433_RS14240 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS14250 ENOG4105C98 muts2 protein Q433_RS14255 ENOG4105DCG PHP domain protein Q433_RS14270 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Q433_RS14275 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Q433_RS14280 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Q433_RS14290 ENOG4108RWN rrna methyltransferase Q433_RS14295 ENOG41067MF small acid-soluble spore protein Q433_RS14305 ENOG4105CQB FAD linked oxidase domain protein Q433_RS14310 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Q433_RS14330 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Q433_RS14335 ENOG4105DRS transport system, permease Q433_RS14350 ENOG4108MDK Dehydrogenase Q433_RS14360 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase Q433_RS14365 ENOG4105EF1 ribulokinase Q433_RS14375 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase Q433_RS14380 ENOG4105CN9 Peptidase m42 family protein Q433_RS14390 ENOG410696E Membrane Q433_RS14395 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Q433_RS14400 ENOG4105VJV 50s ribosomal protein L35 Q433_RS14405 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Q433_RS14415 ENOG41067MG lrgb family Q433_RS14425 ENOG4105DY9 regulatoR Q433_RS14430 ENOG4108HRK Histidine kinase Q433_RS14440 ENOG4105C22 threonyL-tRNA synthetase Q433_RS14445 ENOG4108TDW sporulation protein YtxC Q433_RS14465 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Q433_RS14470 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Q433_RS14475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Q433_RS14480 ENOG4105KVH Transcriptional regulator Q433_RS14485 ENOG4105F27 Major Facilitator Q433_RS14490 ENOG4105CV8 reductase Q433_RS14495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Q433_RS14510 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Q433_RS14515 ENOG4105C2M dna polymerase I Q433_RS14520 ENOG4105BZU Histidine kinase Q433_RS14525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Q433_RS14530 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Q433_RS14535 ENOG4108HMX isocitrate dehydrogenase (NADP) Q433_RS14540 ENOG4105BZN citrate synthase Q433_RS14550 ENOG4108REF Sporulation integral membrane protein ytvi Q433_RS14555 ENOG4105FS0 cytoplasmic membrane protein Q433_RS14560 ENOG4105CA9 Pyruvate kinase Q433_RS14565 ENOG4105CTQ phosphohexokinase Q433_RS14575 ENOG4108IEY Carboxyl transferase domain Q433_RS14580 ENOG4105C6K Malic enzyme Q433_RS14585 ENOG4105C0B DNA polymerase III (alpha subunit) Q433_RS14590 ENOG4105VV2 Q433_RS14600 ENOG4106EVM Q433_RS14605 ENOG4105SFS phosphoesterase RecJ domain protein Q433_RS14625 ENOG410635A Membrane Q433_RS14630 ENOG4105CH2 amidohydrolase Q433_RS14650 ENOG4105DEN Luciferase family Q433_RS14655 ENOG4105CDA abc transporter atp-binding protein Q433_RS14680 ENOG4108XSB acetyltransferase, (GNAT) family Q433_RS14685 ENOG4108KSA LysR family transcriptional regulator Q433_RS14690 ENOG4105E8R UPF0173 metal-dependent hydrolase Q433_RS14705 ENOG4105CH7 arginosuccinase Q433_RS14710 ENOG4105CDH Citrulline--aspartate ligase Q433_RS14715 ENOG4105EPU Molybdenum cofactor synthesis domain protein Q433_RS14720 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Q433_RS14730 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Q433_RS14735 ENOG4105KBJ sporulation protein ytfj Q433_RS14745 ENOG4105VK3 rdd domain containing protein Q433_RS14750 ENOG4105D07 Signal peptide peptidase, SppA Q433_RS14755 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Q433_RS14760 ENOG4105EFZ amidohydrolase Q433_RS14765 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Q433_RS14800 ENOG4105U5Y Transcriptional regulator Q433_RS14810 ENOG4105BZU Histidine kinase Q433_RS14815 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Q433_RS14825 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Q433_RS14835 ENOG4105F1V Acetoin utilization protein Q433_RS14840 ENOG4105W87 Cbs domain Q433_RS14845 ENOG4105DGU Histone deacetylase Q433_RS14850 ENOG4105ER2 Ompa motb domain protein Q433_RS14855 ENOG4107R0U MotA TolQ exbB proton channel Q433_RS14860 ENOG4105ETE Transcriptional regulator (LacI family Q433_RS14865 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Q433_RS14885 ENOG4105DFU Cell wall formation (By similarity) Q433_RS14895 ENOG4108VDD TRNA binding domain protein Q433_RS14910 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ Q433_RS14925 ENOG4105C6K Malic enzyme Q433_RS14930 ENOG4105C8F Beta-lactamase domain protein Q433_RS14935 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Q433_RS14945 ENOG4108V15 phosphotransferase enzyme family Q433_RS14950 ENOG4108IUM Glycogen debranching enzyme Q433_RS14965 ENOG4107F58 2'-5' rna ligase Q433_RS14970 ENOG4105C6T cysteine synthase Q433_RS14975 ENOG4107QSE Dipeptidase Q433_RS14980 ENOG4105C7N Xanthine uracil vitamin C permease Q433_RS14995 ENOG4105YW5 deoR family transcriptional regulator Q433_RS15010 ENOG4105CBX hi0933 family Q433_RS15015 ENOG4105C94 Transporter Q433_RS15025 ENOG4105MU9 integral membrane protein Q433_RS15030 ENOG4105DDC Oxidoreductase domain protein Q433_RS15040 ENOG4105F5H Glycosyl Hydrolase Family 88 Q433_RS15050 ENOG41075H3 AraC family transcriptional regulator Q433_RS15060 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component Q433_RS15070 ENOG4106A3M Cytochrome p-450 Q433_RS15075 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Q433_RS15085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Q433_RS15090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Q433_RS15100 ENOG4105NTD Inherit from COG: Hydrolase Q433_RS15130 ENOG41085GJ domain protein Q433_RS15135 ENOG4105C8T Leucyl-tRNA synthetase Q433_RS15145 ENOG4105BZU Histidine kinase Q433_RS15150 ENOG410605W Major Facilitator Q433_RS15155 ENOG4106UBQ Q433_RS15165 ENOG4105C19 ABC transporter Q433_RS15170 ENOG4105EWM Histidine kinase Q433_RS15180 ENOG4107R34 abc transporter permease protein Q433_RS15185 ENOG4105C19 ABC transporter Q433_RS15200 ENOG4105DVE abc transporter atp-binding protein Q433_RS15205 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Q433_RS15220 ENOG4105N5T Radical SAM Protein Q433_RS15235 ENOG4105E8V Alpha Beta Hydrolase Fold protein Q433_RS15240 ENOG4108Z0R Transferase Q433_RS15245 ENOG4105C85 amino acid Q433_RS15250 ENOG4105CAQ asparagine synthetase Q433_RS15255 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Q433_RS15260 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase Q433_RS15275 ENOG4105D2X ABC transporter substrate-binding protein Q433_RS15285 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Q433_RS15300 ENOG4108RMU ferritin dps family protein Q433_RS15315 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) Q433_RS15320 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Q433_RS15325 ENOG4108V2W Carbonate dehydratase Q433_RS15350 ENOG4105CC5 ABC transporter Q433_RS15355 ENOG4105CC5 ABC transporter Q433_RS15360 ENOG4105DIK (ABC) transporter Q433_RS15365 ENOG4105DSE periplasmic solute binding protein Q433_RS15370 ENOG4105DTQ mandelate racemase muconate lactonizing Q433_RS15375 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS15380 ENOG4108IPT Naphthoate synthase Q433_RS15385 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Q433_RS15390 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Q433_RS15395 ENOG4105E4F Isochorismate synthase Q433_RS15415 ENOG4108IAJ Nad-dependent epimerase dehydratase Q433_RS15420 ENOG4107SBE Glycosyl transferase (Group 1 Q433_RS15435 ENOG4107SBE Glycosyl transferase (Group 1 Q433_RS15440 ENOG4108KS4 Spore coat protein Q433_RS15455 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) Q433_RS15465 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Q433_RS15600 ENOG4105N67 Proton-coupled thiamine transporter YuaJ Q433_RS15605 ENOG4105VRR gCN5-related N-acetyltransferase Q433_RS15610 ENOG4105DZ6 Band 7 protein Q433_RS15620 ENOG4106DF1 Q433_RS15625 ENOG4108VNY MOSC domain protein Q433_RS15630 ENOG4108JB8 alcohol dehydrogenase Q433_RS15640 ENOG4105TRT Transcriptional regulator Q433_RS15655 ENOG4105CZN Potassium uptake protein Q433_RS15660 ENOG4107I77 yiaA/B two helix domain Q433_RS15665 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj Q433_RS15685 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Q433_RS15695 ENOG4105EE0 oxidoreductase Q433_RS15700 ENOG4105DKG l-rhamnose isomerase Q433_RS15705 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) Q433_RS15710 ENOG4105DET Rhamnulokinase Q433_RS15715 ENOG4105E98 transcriptional regulator DeoR family Q433_RS15730 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS15735 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS15740 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS15745 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS15760 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme Q433_RS15770 ENOG4105C37 (CBS) domain Q433_RS15785 ENOG4107PBV potassium channel Q433_RS15790 ENOG4107PBV potassium channel Q433_RS15805 ENOG4107QYV phosphohexose isomerase Q433_RS15815 ENOG4107QW4 alcohol dehydrogenase Q433_RS15820 ENOG4105WG9 Conserved Protein Q433_RS15830 ENOG4105CHM Aminotransferase Q433_RS15835 ENOG4108ZB6 transcriptional regulator AsnC family Q433_RS15840 ENOG4108MUZ hydrolase Q433_RS15850 ENOG4105C87 Aminotransferase class I and II Q433_RS15855 ENOG4108HGU Histidine kinase Q433_RS15860 ENOG4105Y38 Kinase-associated protein B Q433_RS15880 ENOG4105BZ4 penicillin-binding protein Q433_RS15885 ENOG4105KIR Thiol-disulfide oxidoreductase dcc Q433_RS15900 ENOG4108MRH transcriptional regulatory protein Q433_RS15905 ENOG4105DIH basic membrane Q433_RS15910 ENOG4108JQ9 ABC transporter Q433_RS15915 ENOG4105UIB (ABC) transporter Q433_RS15935 ENOG4105D65 subunit l Q433_RS15940 ENOG4105HC0 Na H antiporter Q433_RS15945 ENOG4108ZE9 Monovalent cation H antiporter subunit C Q433_RS15950 ENOG4108JPZ Monovalent cation H antiporter subunit D Q433_RS15955 ENOG4105SC1 monovalent cation H antiporter subunit E Q433_RS15965 ENOG4105KJM monovalent cation h antiporter subunit g Q433_RS15970 ENOG4105KA0 thioesterase Superfamily protein Q433_RS15980 ENOG4105BZU Histidine kinase Q433_RS16005 ENOG4105D58 Diguanylate phosphodiesterase Q433_RS16010 ENOG4105DAP Nicotinate phosphoribosyltransferase Q433_RS16035 ENOG4105C02 permease Q433_RS16055 ENOG410904N short-chain dehydrogenase reductase Q433_RS16090 ENOG4108K8K Transcriptional regulator Q433_RS16095 ENOG4105DCF alanine dehydrogenase Q433_RS16105 ENOG4105WQT MbtH domain protein Q433_RS16110 ENOG4105CEY Amp-dependent synthetase and ligase Q433_RS16115 ENOG4105WQI isochorismatase Q433_RS16120 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Q433_RS16125 ENOG4105E4F Isochorismate synthase Q433_RS16130 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase Q433_RS16135 ENOG4105NIV Esterase Q433_RS16155 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Q433_RS16165 ENOG41069ER domain protein Q433_RS16180 ENOG4105CEP NADH dehydrogenase Q433_RS16185 ENOG4105CAY ferredoxin--nadp reductase Q433_RS16205 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 Q433_RS16210 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Q433_RS16225 ENOG4105ZKE UPF0349 protein Q433_RS16240 ENOG41083MR nifu domain-containing protein Q433_RS16245 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Q433_RS16250 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Q433_RS16255 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Q433_RS16260 ENOG4105D6E homoserine dehydrogenase Q433_RS16270 ENOG4108W5N phosphatidylglycerophosphatase a Q433_RS16275 ENOG4105D4U had-superfamily hydrolase, subfamily iia Q433_RS16285 ENOG4105MMD transcriptional regulator Q433_RS16290 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Q433_RS16295 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Q433_RS16300 ENOG4105FAA peptidase M23 Q433_RS16305 ENOG4108YTE sporulation protein YunB Q433_RS16310 ENOG4105KZD Domain of unknown function (DUF1805) Q433_RS16315 ENOG4107R8B 5'-nucleotidase Q433_RS16325 ENOG4105I3N Conserved Protein Q433_RS16335 ENOG4105CD3 dihydroorotase Q433_RS16340 ENOG4105G9B Transcriptional regulator Q433_RS16355 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) Q433_RS16360 ENOG4105VT2 5-hydroxyisourate hydrolase Q433_RS16370 ENOG4107YV9 domain protein Q433_RS16375 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Q433_RS16390 ENOG4105XRQ Xanthine dehydrogenase accessory factor Q433_RS16395 ENOG4105C5R Aminotransferase Q433_RS16410 ENOG4108K8S endonuclease I Q433_RS16415 ENOG4108IJ9 (ABC) transporter Q433_RS16420 ENOG4105FDP GntR family transcriptional regulator Q433_RS16425 ENOG4108KPW sugar kinase Q433_RS16430 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component Q433_RS16435 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component Q433_RS16440 ENOG4105XN3 extracellular solute-binding protein family 1 Q433_RS16445 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine Q433_RS16450 ENOG4105PKS Excinuclease abc c subunit domain protein Q433_RS16455 ENOG4107VFR oxidoreductase Q433_RS16470 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS16475 ENOG4105NPE arsR family transcriptional regulator Q433_RS16480 ENOG4105DIW FeS assembly protein SUFB Q433_RS16485 ENOG4108UNV SUF system FeS assembly protein, NifU family Q433_RS16490 ENOG4105C9B Cysteine desulfurase Q433_RS16495 ENOG4105JRK feS assembly protein SufD Q433_RS16500 ENOG4105C3K feS assembly ATPase SufC Q433_RS16515 ENOG4105D01 (LipO)protein Q433_RS16520 ENOG4108UMI ABC transporter, permease Q433_RS16525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Q433_RS16550 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Q433_RS16555 ENOG41080E8 Transcriptional regulator, Spx MgsR family Q433_RS16560 ENOG4105C1G acyl-Coa dehydrogenase Q433_RS16565 ENOG4105CHU acetyl-coa acetyltransferase Q433_RS16595 ENOG41067TZ transcriptional regulator, MarR family Q433_RS16600 ENOG4105C0R drug resistance transporter emrb qaca subfamily Q433_RS16605 ENOG4105MDS 4-oxalocrotonate tautomerase Q433_RS16615 ENOG4105EGI Transcriptional regulator Q433_RS16625 ENOG4105E0A ABC, transporter Q433_RS16640 ENOG4105E1F short-chain dehydrogenase reductase Q433_RS16645 ENOG4105HUF DNA protection during starvation protein Q433_RS16650 ENOG4105C0H protease Q433_RS16660 ENOG4105F3H Histidine kinase Q433_RS16670 ENOG41067SE Tetr family transcriptional regulator Q433_RS16675 ENOG4105C9Q fumarate hydratase class II Q433_RS16700 ENOG4105WH1 Two component transcriptional regulator luxr family Q433_RS16705 ENOG4105ENE Histidine kinase Q433_RS16720 ENOG41087YS Phage shock protein A Q433_RS16735 ENOG4108WBT adenosyltransferase Q433_RS16740 ENOG4105E0A ABC, transporter Q433_RS16745 ENOG4105EHG Permease protein Q433_RS16750 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Q433_RS16760 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Q433_RS16765 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Q433_RS16775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Q433_RS16785 ENOG4106DF4 Sigma-70, region 4 Q433_RS16795 ENOG4105F0F Oxalate decarboxylase Q433_RS16805 ENOG4107RBB ABC transporter, permease Q433_RS16810 ENOG4105C19 ABC transporter Q433_RS16815 ENOG4108WMK Efflux transporter RND family MFP subunit Q433_RS16820 ENOG4105E0A ABC, transporter Q433_RS16825 ENOG4105EHG Permease protein Q433_RS16830 ENOG4105DQ5 transport system permease protein Q433_RS16845 ENOG4105D5Q Arginine ornithine antiporter Q433_RS16855 ENOG4107K5X Membrane-bound metal-dependent hydrolase Q433_RS16860 ENOG4107QZ2 Sulfatase Q433_RS16865 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Q433_RS16870 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Q433_RS16875 ENOG4105E0C molybdate abc transporter Q433_RS16890 ENOG4105EEQ Na H antiporter Q433_RS16895 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Q433_RS16900 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Q433_RS16905 ENOG4105EEM helicase Q433_RS16915 ENOG4105EN6 Membrane Q433_RS16925 ENOG4107ZQN disulfide bond Q433_RS16930 ENOG4105C59 p-type ATPase Q433_RS16935 ENOG4105C59 p-type ATPase Q433_RS16940 ENOG410681U heavy metal transport detoxification protein Q433_RS16945 ENOG4105VPX protein, conserved in bacteria Q433_RS16950 ENOG4105D9R oxidoreductase Q433_RS16955 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Q433_RS16960 ENOG4105ME7 Membrane Q433_RS16965 ENOG4105RXJ Q433_RS16970 ENOG4105KPY Small multidrug resistance protein Q433_RS16975 ENOG4105KBX Transcriptional regulator, TetR family Q433_RS16980 ENOG4105EWI Short-chain dehydrogenase reductase Sdr Q433_RS16985 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Q433_RS16990 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Q433_RS17000 ENOG4105XZU Preprotein translocase, subunit SecG Q433_RS17025 ENOG4105KVH Transcriptional regulator Q433_RS17030 ENOG4105C8Q Methyl-accepting chemotaxis Q433_RS17035 ENOG4105R40 Glycine betaine carnitine choline Q433_RS17040 ENOG4108HQR Glycine betaine Q433_RS17045 ENOG4105E90 ABC transporter Q433_RS17050 ENOG4108IJ8 ABC transporter Q433_RS17055 ENOG4107HG4 Transcriptional regulator Q433_RS17060 ENOG4105R40 Glycine betaine carnitine choline Q433_RS17065 ENOG4108HQR Glycine betaine Q433_RS17070 ENOG4105E90 ABC transporter Q433_RS17075 ENOG4108IJ8 ABC transporter Q433_RS17080 ENOG4107HG4 Transcriptional regulator Q433_RS17085 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein Q433_RS17090 ENOG4108QCI YvbH-like oligomerisation region Q433_RS17100 ENOG4105T65 Membrane-associated protein Q433_RS17105 ENOG4108W0I acetyltransferase Q433_RS17110 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Q433_RS17115 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Q433_RS17120 ENOG4105CP7 Triose-phosphate isomerase Q433_RS17125 ENOG4105BZA Phosphoglycerate kinase Q433_RS17135 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Q433_RS17150 ENOG4105CMD Transcriptional regulator, GntR family Q433_RS17155 ENOG4105DEN Luciferase family Q433_RS17165 ENOG4105GZI Transcriptional regulator Q433_RS17170 ENOG4107RT3 EamA-like transporter family Q433_RS17180 ENOG4105VRS hydrolase family 18 Q433_RS17185 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) Q433_RS17190 ENOG4107QR9 Iron-sulfur cluster binding protein Q433_RS17195 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Q433_RS17205 ENOG4105BZU Histidine kinase Q433_RS17210 ENOG4105KCT ABC transporter Q433_RS17215 ENOG4108M15 ABC transporter Q433_RS17220 ENOG4107R6F Alpha Beta Hydrolase Fold protein Q433_RS17225 ENOG4108MJI response regulator Q433_RS17240 ENOG4105EG2 ABC transporter, permease Q433_RS17250 ENOG4107FKK extracellular solute-binding protein family 1 Q433_RS17260 ENOG4105JXH GntR family transcriptional regulator Q433_RS17265 ENOG4105DAA L-lactate Q433_RS17270 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Q433_RS17280 ENOG4108ZPC Polysaccharide pyruvyl transferase Q433_RS17285 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Q433_RS17290 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family Q433_RS17295 ENOG4105D3Q Sugar transferase Q433_RS17305 ENOG4105K64 Glycosyl transferase, family 2 Q433_RS17315 ENOG4107QRS glycosyltransferase group 2 family protein Q433_RS17320 ENOG41068W6 Capsular polysaccharide biosynthesis protein Q433_RS17325 ENOG4108KMV Glycosyl transferase (Group 1 Q433_RS17330 ENOG4105K64 Glycosyl transferase, family 2 Q433_RS17335 ENOG4108PQP glycosyl transferase group 1 Q433_RS17345 ENOG4108QV3 biosynthesis protein Q433_RS17350 ENOG4105HTX biosynthesis protein Q433_RS17360 ENOG4105EBR Carboxylesterase Q433_RS17370 ENOG4105PY6 Phenolic acid decarboxylase Q433_RS17375 ENOG4105NI3 Protein of unknown function (DUF3237) Q433_RS17385 ENOG4105FQP Beta-lactamase Q433_RS17390 ENOG4105EDQ levansucrase EC 2.4.1.10 Q433_RS17395 ENOG4108HKT sucrose-6-phosphate hydrolase Q433_RS17400 ENOG4107QTZ amino acid Q433_RS17425 ENOG4105DNP FAD linked oxidase domain protein Q433_RS17430 ENOG4105IRW patatin-like phospholipase family protein Q433_RS17440 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Q433_RS17445 ENOG4107URF beta-phospho-glucomutase Q433_RS17450 ENOG4105CG3 alpha amylase, catalytic region Q433_RS17465 ENOG4105EG2 ABC transporter, permease Q433_RS17470 ENOG4105D56 permease protein Q433_RS17475 ENOG4107FKK extracellular solute-binding protein family 1 Q433_RS17480 ENOG4108IUK alpha amylase, catalytic Q433_RS17485 ENOG4105FKQ transcriptional regulator Q433_RS17490 ENOG4108URH decarboxylase Q433_RS17495 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain Q433_RS17500 ENOG4105CHH sulfate transporter Q433_RS17505 ENOG4108V2W Carbonate dehydratase Q433_RS17510 ENOG4105C5I Dehydrogenase Q433_RS17520 ENOG4105C19 ABC transporter Q433_RS17525 ENOG4105EWM Histidine kinase Q433_RS17535 ENOG4107A6P Q433_RS17540 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase Q433_RS17545 ENOG4105KRI phosphocarrier protein (HPr Q433_RS17550 ENOG4105CIE May be required for sporulation (By similarity) Q433_RS17555 ENOG4105CHW UPF0052 protein Q433_RS17560 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Q433_RS17565 ENOG4108Z4K mutator MutT protein Q433_RS17570 ENOG4105C3M thioredoxin reductase Q433_RS17585 ENOG4105BZ1 (ABC) transporter Q433_RS17595 ENOG4106FGC Q433_RS17605 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Q433_RS17610 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Q433_RS17615 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Q433_RS17620 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Q433_RS17625 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Q433_RS17630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Q433_RS17635 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Q433_RS17640 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) Q433_RS17650 ENOG4108E16 pectate lyase Q433_RS17655 ENOG4108S4C acetyltransferase Q433_RS17660 ENOG4107XGZ Hydrolase Q433_RS17665 ENOG4105HKU nucleoside recognition domain-containing protein Q433_RS17670 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Q433_RS17675 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Q433_RS17680 ENOG4105CE4 GlcNAc 6-P deacetylase Q433_RS17685 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) Q433_RS17695 ENOG41088CQ domain protein Q433_RS17705 ENOG4106A3M Cytochrome p-450 Q433_RS17710 ENOG410625E Q433_RS17725 ENOG41086DT Membrane protein of unknown function Q433_RS17730 ENOG41067S9 phage shock protein C, PspC Q433_RS17735 ENOG4108PY7 Q433_RS17750 ENOG4105I03 Flagellin Q433_RS17755 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Q433_RS17760 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Q433_RS17775 ENOG4105MKU Transcriptional regulator Q433_RS17795 ENOG4105CN1 protease Q433_RS17800 ENOG4105CRP Part of the ABC transporter FtsEX involved in Q433_RS17805 ENOG4105CAK Cell division ATP-binding protein ftsE Q433_RS17830 ENOG4105MS2 ribosomal subunit Interface protein Q433_RS17845 ENOG4105MQ3 flagellar protein FliS Q433_RS17850 ENOG4107RT6 flagellar hook-associated Q433_RS17855 ENOG41083S7 flagellar protein FlaG Q433_RS17860 ENOG4105I03 Flagellin Q433_RS17865 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Q433_RS17870 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) Q433_RS17875 ENOG4105MKD Q433_RS17880 ENOG4105DTJ flagellar hook-associated protein Q433_RS17885 ENOG4105E1Q flagellar hook-associated protein Q433_RS17900 ENOG4105RU3 Q433_RS17905 ENOG41081UC Inherit from COG: Competence protein Q433_RS17925 ENOG4105WH1 Two component transcriptional regulator luxr family Q433_RS17930 ENOG4105BZU Histidine kinase Q433_RS17935 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Q433_RS17940 ENOG4108KGH TRANSCRIPTIONal Q433_RS17945 ENOG4105ESV Glycosyl transferase, family 4 Q433_RS17950 ENOG4107EF8 Glycosyl transferase (Group 1 Q433_RS17965 ENOG4105QZI O-Antigen Polymerase Q433_RS17970 ENOG4105C6Y Udp-glucose 6-dehydrogenase Q433_RS17975 ENOG4107RA4 Glycosyl transferase (Group 1 Q433_RS17980 ENOG4105PSV Polysaccharide Biosynthesis Protein Q433_RS17985 ENOG4105D3Q Sugar transferase Q433_RS17995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Q433_RS18000 ENOG4105JFG SpoIID LytB domain protein Q433_RS18015 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Q433_RS18035 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Q433_RS18040 ENOG4105EY8 ABC transporter Q433_RS18060 ENOG4107VDP teichoic acid biosynthesis Q433_RS18065 ENOG41088M2 Glycosyl transferase family 2 Q433_RS18115 ENOG4105DG6 mannose-6-phosphate isomerase Q433_RS18135 ENOG4108NHD germination protein Q433_RS18140 ENOG4105C54 Major Facilitator superfamily Q433_RS18145 ENOG4108KGH TRANSCRIPTIONal Q433_RS18150 ENOG4105J7I hydrolase Q433_RS18155 ENOG4105K4H Nlp p60 protein Q433_RS18165 ENOG4105PNM synthesis protein Q433_RS18175 ENOG4105N98 Capsule biosynthesis protein capB Q433_RS18180 ENOG4105ETE Transcriptional regulator (LacI family Q433_RS18185 ENOG4108RVA ribokinase Q433_RS18190 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) Q433_RS18195 ENOG4105C2J ABC transporter Q433_RS18200 ENOG4105CNN ABC, transporter Q433_RS18205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Q433_RS18220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Q433_RS18225 ENOG4107FQX Alpha-acetolactate decarboxylase Q433_RS18235 ENOG4107RSM transcriptional regulator Q433_RS18250 ENOG4106UIA Q433_RS18265 ENOG4107XC4 flavin reductase domain protein, FMN-binding Q433_RS18275 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Q433_RS18285 ENOG4105CAH Chromate Q433_RS18290 ENOG4105FGV Chromate Q433_RS18300 ENOG4108WS4 fmn reductase Q433_RS18305 ENOG4107V2S Transcriptional regulator Q433_RS18310 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) Q433_RS18350 ENOG4108XI2 Domain of unknown function (DUF1963) Q433_RS18355 ENOG4105C6Y Udp-glucose 6-dehydrogenase Q433_RS18360 ENOG4108RB3 Capsular polysaccharide biosynthesis protein Q433_RS18365 ENOG4107YJ4 chain length determinant protein Q433_RS18370 ENOG4105HTX biosynthesis protein Q433_RS18380 ENOG4105KBK Zinc finger, swim domain protein Q433_RS18385 ENOG4105C0D helicase Q433_RS18390 ENOG410667J hydrolase Q433_RS18395 ENOG4105E98 transcriptional regulator DeoR family Q433_RS18400 ENOG4105Z8H single-stranded DNA-binding protein Q433_RS18425 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Q433_RS18430 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Q433_RS18440 ENOG4105CGA flagellar basal-body rod protein FlgG Q433_RS18450 ENOG4105DFF Rod shape-determining protein mreb Q433_RS18455 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Q433_RS18460 ENOG4107MII Sugar-specific transcriptional regulator TrmB Q433_RS18465 ENOG4105CZM Major Facilitator Q433_RS18470 ENOG4108M26 parallel beta-helix repeat protein Q433_RS18475 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease Q433_RS18480 ENOG41080V3 Major Facilitator superfamily Q433_RS18485 ENOG4105D3W isochorismatase Q433_RS18490 ENOG4107P26 Q433_RS18495 ENOG4105BZU Histidine kinase Q433_RS18505 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Q433_RS18515 ENOG4105FRN stage II sporulation protein Q433_RS18520 ENOG4107TCE N-acetyltransferase Q433_RS18540 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Q433_RS18545 ENOG4107TXC Transcriptional regulator Q433_RS18550 ENOG4106BRK Q433_RS18555 ENOG4108RYK Nad-dependent epimerase dehydratase Q433_RS18560 ENOG4108Z40 Transcriptional regulator Q433_RS18565 ENOG4105CQM Urea amidohydrolase subunit alpha Q433_RS18570 ENOG4105KI2 Urea amidohydrolase subunit beta Q433_RS18575 ENOG4108YZ9 Urea amidohydrolase subunit gamma Q433_RS18610 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Q433_RS18620 ENOG4108TF4 von Willebrand factor, type A Q433_RS18635 ENOG4105JFG SpoIID LytB domain protein Q433_RS18640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Q433_RS18650 ENOG4106778 Protein of unknown function (DUF1146) Q433_RS18660 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Q433_RS18665 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Q433_RS18670 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Q433_RS18675 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Q433_RS18700 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) Q433_RS18710 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Q433_RS18715 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Q433_RS18720 ENOG4108UIC UPF0340 protein Q433_RS18725 ENOG4108YZG isomerase Q433_RS18730 ENOG4107WAU Protein tyrosine phosphatase Q433_RS18735 ENOG410815N Probably functions as a manganese efflux pump (By similarity) Q433_RS18740 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Q433_RS18750 ENOG4108ZXQ stage ii sporulation protein r Q433_RS18765 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Q433_RS18770 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Q433_RS18775 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase Q433_RS18785 ENOG4107TT2 Auxin Efflux Carrier Q433_RS18790 ENOG4105C6K Malic enzyme Q433_RS18795 ENOG4107104 thymidine kinase Q433_RS18805 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Q433_RS18815 ENOG4105CBT Fructose-1,6-bisphosphatase Q433_RS18820 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Q433_RS18825 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway Q433_RS18830 ENOG4105D2N Aldolase Q433_RS18835 ENOG410812K response regulator receiver protein Q433_RS18845 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Q433_RS18855 ENOG4105C1G acyl-Coa dehydrogenase Q433_RS18860 ENOG4105DF6 Fe-S oxidoreductase Q433_RS18870 ENOG4105E5J UV damage endonuclease Q433_RS18880 ENOG4105NAE bifunctional deaminase-reductase domain protein Q433_RS18885 ENOG4105BZ1 (ABC) transporter Q433_RS18890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Q433_RS18905 ENOG4105R3A Nitrate reductase Q433_RS18910 ENOG4108IUE nitrate reductase beta subunit Q433_RS18930 ENOG4107V6Q Cyclic nucleotide-binding domain Q433_RS18940 ENOG4105C75 arginyL-tRNA synthetase Q433_RS18945 ENOG410684U Domain of unknown function (DUF1934) Q433_RS18955 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E Q433_RS19005 ENOG4107JM4 Tetratricopeptide repeat Q433_RS19035 ENOG4108RDQ ABC transporter Q433_RS19045 ENOG4105CYW agmatinase Q433_RS19050 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Q433_RS19055 ENOG4105BZ4 penicillin-binding protein Q433_RS19060 ENOG4108XFG YwhD family Q433_RS19065 ENOG4108Z4T Peptidase M50 Q433_RS19070 ENOG41069HH 4-oxalocrotonate tautomerase Q433_RS19075 ENOG41067TZ transcriptional regulator, MarR family Q433_RS19080 ENOG4105C22 threonyL-tRNA synthetase Q433_RS19090 ENOG4105C57 major facilitator superfamily Q433_RS19095 ENOG41062ES Transcriptional regulator Q433_RS19105 ENOG4105DCI Phosphohydrolase Q433_RS19115 ENOG4108VCI transcription factor, rsfa family Q433_RS19120 ENOG4108RNG Permease of the drug metabolite transporter Q433_RS19125 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) Q433_RS19130 ENOG4105DUM transcriptional regulator, lysR family Q433_RS19135 ENOG4108IJ2 phosphate acetyltransferase Q433_RS19150 ENOG4105CHM Aminotransferase Q433_RS19160 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase Q433_RS19165 ENOG4105CHR reductase Q433_RS19170 ENOG4106CHD Bacilysin biosynthesis protein bacB Q433_RS19175 ENOG41061WN bacilysin biosynthesis protein Q433_RS19180 ENOG4105FCW Major Facilitator superfamily Q433_RS19195 ENOG4105C26 Dehydrogenase Q433_RS19200 ENOG4105D82 Glutamate dehydrogenase Q433_RS19210 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase Q433_RS19215 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Q433_RS19220 ENOG4105C1B dTDP-glucose 4-6-dehydratase Q433_RS19225 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Q433_RS19230 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG Q433_RS19235 ENOG4107TY6 Acylneuraminate cytidylyltransferase Q433_RS19245 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD Q433_RS19250 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Q433_RS19290 ENOG4105C26 Dehydrogenase Q433_RS19295 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Q433_RS19300 ENOG4108RJ9 Glycosyl transferase, family 2 Q433_RS19305 ENOG4105DWF phosphomethylpyrimidine kinase Q433_RS19320 ENOG4105C5Y PTS System Q433_RS19325 ENOG4108QTI )-transporter Q433_RS19340 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS19345 ENOG4105DEN Luciferase family Q433_RS19350 ENOG4108DBC nitroreductase Q433_RS19365 ENOG41060D1 Quinol oxidase Q433_RS19370 ENOG4105CCU oxidase (Subunit III) Q433_RS19375 ENOG4105BZ9 Cytochrome C oxidase, subunit I Q433_RS19380 ENOG4105E2S oxidase) subunit II Q433_RS19385 ENOG4107BMA Transglycosylase associated protein Q433_RS19395 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Q433_RS19400 ENOG4105WH5 Teichoic acid glycosylation protein Q433_RS19425 ENOG4107ZXU DSBA oxidoreductase Q433_RS19430 ENOG4105DBE peroxidase Q433_RS19435 ENOG410650H (LipO)protein Q433_RS19440 ENOG4107SJW iron permease, FTR1 Q433_RS19445 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Q433_RS19455 ENOG4105CMU LysR family (Transcriptional regulator Q433_RS19460 ENOG4105VAW lrga family Q433_RS19465 ENOG41067MG lrgb family Q433_RS19470 ENOG4105D8G Major Facilitator superfamily Q433_RS19480 ENOG4105DR4 Methyltransferase Q433_RS19490 ENOG4105CK1 PTS System Q433_RS19495 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin Q433_RS19510 ENOG4105X1N Glycosyl transferase family 8 Q433_RS19520 ENOG4105GVJ transcriptional regulator Q433_RS19525 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Q433_RS19530 ENOG4105IIU Aminopeptidase Q433_RS19555 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Q433_RS19570 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) Q433_RS19575 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Q433_RS19585 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD Q433_RS19590 ENOG4108VHC Short-chain dehydrogenase reductase Sdr Q433_RS19595 ENOG4105CM2 brancheD-chain amino acid aminotransferase Q433_RS19600 ENOG4105F8D glycoside hydrolase family 4 Q433_RS19605 ENOG4105VCP PTS System Q433_RS19610 ENOG4105CK1 PTS System Q433_RS19615 ENOG4105VZJ PTS System Q433_RS19620 ENOG4105EMD TRANSCRIPTIONal Q433_RS19630 ENOG4108VX5 3-methyladenine DNA glycosylase Q433_RS19635 ENOG4105CH6 catalase Q433_RS19650 ENOG4105DA5 (ABC) transporter Q433_RS19655 ENOG41069JR Q433_RS19675 ENOG4105ETS cytosine purines uracil thiamine allantoin Q433_RS19680 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Q433_RS19685 ENOG4108JJ8 (ABC) transporter Q433_RS19690 ENOG4108JJ9 ABC, transporter Q433_RS19695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Q433_RS19700 ENOG4105C4M (Ubiquinol oxidase) subunit I Q433_RS19705 ENOG4105D2K citrate carrier protein Q433_RS19720 ENOG4107BJW polysaccharide deacetylase Q433_RS19740 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) Q433_RS19750 ENOG4105CMR udp-glucose 4-epimerase Q433_RS19755 ENOG4105KIS phospholipid-binding protein Q433_RS19760 ENOG4108WAV Transcriptional regulator Q433_RS19770 ENOG4105BZU Histidine kinase Q433_RS19775 ENOG4105WH1 Two component transcriptional regulator luxr family Q433_RS19780 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Q433_RS19810 ENOG4105DTD Dehydrogenase Q433_RS19815 ENOG4108IIH CoA-transferase subunit B Q433_RS19820 ENOG4105D6N CoA-transferase, subunit a Q433_RS19825 ENOG4105CY2 Citrate transporter Q433_RS19835 ENOG4105DHI Methyltransferase Q433_RS19855 ENOG4105CH6 catalase Q433_RS19860 ENOG4105D4T Citrate transporter Q433_RS19865 ENOG4108RZ2 Glycoside hydrolase family 16 Q433_RS19870 ENOG4105CID antiterminator Q433_RS19880 ENOG4105DEU major facilitator superfamily Q433_RS19885 ENOG4105C1J atp-dependent rna helicase Q433_RS19890 ENOG4107TDE lipolytic protein G-D-S-L family Q433_RS19940 ENOG4105CNA YD repeat protein Q433_RS19975 ENOG4107YZX Universal stress protein Q433_RS19980 ENOG4105CS2 ec 3.2.1.21 Q433_RS19985 ENOG4105C5Y PTS System Q433_RS20000 ENOG4107EV6 Inherit from COG: YD repeat protein Q433_RS20015 ENOG4106Z5D Glycoside Hydrolase Family 43 Q433_RS20030 ENOG4105C84 Histidine ammonia-lyase Q433_RS20035 ENOG4105CGP Urocanate hydratase Q433_RS20040 ENOG4105CI2 imidazolone-5-propionate hydrolase Q433_RS20045 ENOG4107W25 arginase agmatinase formiminoglutamase Q433_RS20055 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Q433_RS20060 ENOG4105D9N nucleoside Q433_RS20070 ENOG4107RHR regulatoR Q433_RS20075 ENOG4108TM9 integral membrane protein Q433_RS20080 ENOG4105ENY Ethanolamine utilization protein eutH Q433_RS20085 ENOG4108PGP mmge prpd family protein Q433_RS20100 ENOG4108HW4 amino acid AbC transporter Q433_RS20105 ENOG4105EAB amino acid AbC transporter Q433_RS20125 ENOG4107QHE Choloylglycine hydrolase Q433_RS20130 ENOG410667J hydrolase Q433_RS20160 ENOG4108V5C ABC transporter Q433_RS20190 ENOG4105D2N Aldolase Q433_RS20195 ENOG4107TRN Xylose isomerase domain protein TIM barrel Q433_RS20200 ENOG4105F0H myo-inositol catabolism protein Q433_RS20205 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) Q433_RS20215 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Q433_RS20220 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Q433_RS20225 ENOG4105D7K pfkb domain protein Q433_RS20235 ENOG4105C26 Dehydrogenase Q433_RS20245 ENOG4105CPC Aldo Keto reductase Q433_RS20260 ENOG4107QNK )-transporter Q433_RS20275 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Q433_RS20280 ENOG4105ST3 Transcriptional regulator Q433_RS20285 ENOG4105C26 Dehydrogenase Q433_RS20295 ENOG4108ITS PQQ enzyme repeat Q433_RS20305 ENOG41085PJ rdd domain containing protein Q433_RS20320 ENOG4105J7D transcriptional regulator Q433_RS20325 ENOG4107JEE Short-chain dehydrogenase reductase Sdr Q433_RS20330 ENOG41061AU MarR family Transcriptional regulator Q433_RS20340 ENOG41067MG lrgb family Q433_RS20350 ENOG4105BZW Glycerate kinase Q433_RS20355 ENOG4105G3Z GntR family transcriptional regulator Q433_RS20360 ENOG4105CMG Carbohydrate kinase Q433_RS20365 ENOG4105C6Z Gluconate Q433_RS20370 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Q433_RS20375 ENOG4105D3R alkyl hydroperoxide reductase Q433_RS20380 ENOG4108JU3 Alkyl hydroperoxide reductase Q433_RS20390 ENOG4105CS2 ec 3.2.1.21 Q433_RS20400 ENOG4108S3Y transcriptional regulator Q433_RS20410 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 Q433_RS20440 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Q433_RS20450 ENOG4105E2A Dehydrogenase Q433_RS20470 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) Q433_RS20475 ENOG4105WQG acetyltransferase Q433_RS20480 ENOG410780I phosphoprotein phosphatase activity Q433_RS20490 ENOG41066UZ arginase EC 3.5.3.1 Q433_RS20495 ENOG4108IQI permease Q433_RS20500 ENOG4105C8Y Acetylornithine aminotransferase Q433_RS20505 ENOG4108JUB Transcriptional regulator Q433_RS20510 ENOG4105BZU Histidine kinase Q433_RS20535 ENOG4105C0H protease Q433_RS20540 ENOG4105Q2H domain protein Q433_RS20555 ENOG4105BZU Histidine kinase Q433_RS20560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Q433_RS20585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Q433_RS20590 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS20595 ENOG4105CDU Replicative dna helicase Q433_RS20620 ENOG4105DJ2 Major Facilitator Superfamily Q433_RS20625 ENOG4105EDW glycosyl transferase, family 39 Q433_RS20630 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Q433_RS20635 ENOG4105BZR domain protein Q433_RS20640 ENOG4108XMW Membrane Q433_RS20655 ENOG4105KVH Transcriptional regulator Q433_RS20660 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase Q433_RS20680 ENOG41090E6 transcriptional regulator MERR family Q433_RS20690 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein Q433_RS20695 ENOG4105DDN Pentapeptide repeat-containing protein Q433_RS20700 ENOG4105D94 Major Facilitator Superfamily Q433_RS20705 ENOG4107RSM transcriptional regulator Q433_RS20710 ENOG41082BV acetyltransferase Q433_RS20715 ENOG41081I9 integral membrane protein Q433_RS20725 ENOG4108U05 Transcriptional regulator Q433_RS20730 ENOG41082BV acetyltransferase Q433_RS20740 ENOG4108U7W acetyltransferase Q433_RS20745 ENOG4105UNS Pfam:DUF419 Q433_RS20750 ENOG4105NAE bifunctional deaminase-reductase domain protein Q433_RS20755 ENOG4108J8C transporter major facilitator family protein Q433_RS20760 ENOG4105C7Z Conserved Protein Q433_RS20765 ENOG4107FCW Abortive infection protein Q433_RS20775 ENOG4108UW5 maltose o-acetyltransferase Q433_RS20780 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase Q433_RS20790 ENOG4105CGK Exodeoxyribonuclease III Q433_RS20795 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Q433_RS20800 ENOG4108UUM single-stranded DNA-binding protein Q433_RS20805 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Q433_RS20810 ENOG4105C3G gtp-binding protein Q433_RS20815 ENOG4108J2R molybdopterin oxidoreductase Q433_RS20820 ENOG4105VDK protein, conserved in bacteria Q433_RS20830 ENOG4108ZDA Sporulation protein YyaC Q433_RS20835 ENOG4105FA0 parb-like partition protein Q433_RS20840 ENOG4107QJE Chromosome Partitioning Protein Q433_RS20855 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Q433_RS20860 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Q433_RS20865 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Q433_RS20880 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Q433_RS21395 ENOG4108Z6Z Transcriptional regulator Q433_RS21405 ENOG4105C5Y PTS System