locus-tag	class	description
I33_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I33_RS00010	COG0592	DNA-directed DNA polymerase activity
I33_RS00015	COG2501	S4 domain
I33_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I33_RS00030	COG0187	DNA topoisomerase II activity
I33_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I33_RS00070	COG0517	IMP dehydrogenase activity
I33_RS00070	COG0516	GMP reductase activity
I33_RS00075	COG1686	Belongs to the peptidase S11 family
I33_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I33_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I33_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I33_RS00100	COG1428	Deoxynucleoside kinase
I33_RS00105	COG1428	Deoxynucleoside kinase
I33_RS00110	COG3858	chitin binding
I33_RS00110	COG1388	LysM domain
I33_RS00115	COG1335	isochorismatase
I33_RS00120	COG0590	tRNA wobble adenosine to inosine editing
I33_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I33_RS00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I33_RS00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I33_RS00180	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I33_RS00185	COG3853	Toxic anion resistance protein (TelA)
I33_RS00190	COG1982	Orn Lys Arg decarboxylase major
I33_RS00195	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I33_RS00200	COG3870	Protein conserved in bacteria
I33_RS00205	COG1728	Protein conserved in bacteria
I33_RS00210	COG0470	DNA polymerase III
I33_RS00215	COG1774	PSP1 C-terminal conserved region
I33_RS00220	COG4467	Involved in initiation control of chromosome replication
I33_RS00225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I33_RS00230	COG2827	Endonuclease containing a URI domain
I33_RS00235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I33_RS00240	COG2002	toxin-antitoxin pair type II binding
I33_RS00245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_RS00245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_RS00250	COG0084	hydrolase, TatD family'
I33_RS00255	COG3583	domain protein
I33_RS00255	COG3584	3D domain protein
I33_RS00260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I33_RS00265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I33_RS00275	COG4466	Protein conserved in bacteria
I33_RS00285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I33_RS00290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_RS00295	COG0251	oxidation-reduction process
I33_RS00300	COG2088	sporulation resulting in formation of a cellular spore
I33_RS00305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I33_RS00310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I33_RS00315	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I33_RS00320	COG0193	aminoacyl-tRNA hydrolase activity
I33_RS00330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I33_RS00335	COG2002	toxin-antitoxin pair type II binding
I33_RS00340	COG2244	polysaccharide biosynthetic process
I33_RS00345	COG3956	TIGRFAM MazG family protein
I33_RS00350	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I33_RS00365	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I33_RS00370	COG1098	S1 RNA binding domain
I33_RS00385	COG2208	phosphoserine phosphatase activity
I33_RS00390	COG2304	oxidoreductase activity
I33_RS00395	COG0515	serine threonine protein kinase
I33_RS00400	COG0037	tRNA processing
I33_RS00405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I33_RS00410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I33_RS00415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I33_RS00420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I33_RS00425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I33_RS00430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_RS00435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I33_RS00440	COG0512	Glutamine amidotransferase of anthranilate synthase
I33_RS00445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_RS00450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I33_RS00455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I33_RS00460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I33_RS00465	COG1396	sequence-specific DNA binding
I33_RS00470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I33_RS00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I33_RS00555	COG4463	regulation of RNA biosynthetic process
I33_RS00560	COG3880	PFAM UvrB UvrC protein
I33_RS00565	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I33_RS00570	COG0542	response to heat
I33_RS00575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I33_RS00580	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I33_RS00585	COG4956	integral membrane protein (PIN domain superfamily)
I33_RS00590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I33_RS00595	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I33_RS00600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I33_RS00610	COG1045	serine acetyltransferase
I33_RS00615	COG0215	cysteine-tRNA ligase activity
I33_RS00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I33_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I33_RS00630	COG3688	RNA-binding protein containing a PIN domain
I33_RS00635	COG1595	DNA-templated transcription, initiation
I33_RS00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I33_RS00645	COG0250	Participates in transcription elongation, termination and antitermination
I33_RS00655	COG0081	regulation of translation
I33_RS00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I33_RS00670	COG2813	Specifically methylates the guanine in position
I33_RS00675	COG0085	RNA polymerase activity
I33_RS00680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I33_RS00685	COG1358	cellular component organization or biogenesis
I33_RS00690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I33_RS00695	COG0049	tRNA binding
I33_RS00700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I33_RS00705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I33_RS00710	COG0596	Alpha beta hydrolase
I33_RS00720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I33_RS00725	COG0088	Forms part of the polypeptide exit tunnel
I33_RS00735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I33_RS00755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I33_RS00765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I33_RS00770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I33_RS00780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I33_RS00790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I33_RS00795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I33_RS00800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I33_RS00805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I33_RS00815	COG0200	Binds to the 23S rRNA
I33_RS00820	COG0201	protein transport
I33_RS00825	COG0563	adenylate kinase activity
I33_RS00830	COG0024	Methionine aminopeptidase
I33_RS00835	COG2163	COG2163 Ribosomal protein L14E L6E L27E
I33_RS00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I33_RS00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I33_RS00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I33_RS00860	COG0202	RNA polymerase activity
I33_RS00865	COG0203	ribosomal protein L17
I33_RS00870	COG1122	ATPase activity
I33_RS00875	COG1122	ATPase activity
I33_RS00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I33_RS00885	COG0101	tRNA pseudouridine synthase activity
I33_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I33_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I33_RS00900	COG2226	methyltransferase
I33_RS00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS00915	COG0489	protein tyrosine kinase activity
I33_RS00925	COG2194	sulfuric ester hydrolase activity
I33_RS00930	COG0726	polysaccharide deacetylase
I33_RS01010	COG0659	secondary active sulfate transmembrane transporter activity
I33_RS01015	COG0385	Bile acid
I33_RS01020	COG2819	hydrolase of the alpha beta superfamily
I33_RS01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS01040	COG2207	Transcriptional regulator
I33_RS01045	COG3876	Protein conserved in bacteria
I33_RS01050	COG1472	Belongs to the glycosyl hydrolase 3 family
I33_RS01055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_RS01060	COG1263	PTS System
I33_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS01065	COG1737	Transcriptional regulator
I33_RS01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I33_RS01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS01080	COG1683	Conserved Protein
I33_RS01110	COG1595	DNA-templated transcription, initiation
I33_RS01115	COG5662	AntiSigma factor
I33_RS01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I33_RS01125	COG4856	YbbR-like protein
I33_RS01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I33_RS01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I33_RS01140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I33_RS01145	COG3002	Belongs to the UPF0753 family
I33_RS01150	COG0288	reversible hydration of carbon dioxide
I33_RS01160	COG5609	conserved protein (DUF2294)
I33_RS01165	COG0640	Transcriptional regulator
I33_RS01170	COG2814	Major facilitator Superfamily
I33_RS01185	COG0515	serine threonine protein kinase
I33_RS01200	COG1113	amino acid transport
I33_RS01215	COG2602	Beta-lactamase
I33_RS01220	COG2124	cytochrome p450
I33_RS01230	COG0531	amino acid
I33_RS01240	COG0584	glycerophosphoryl diester phosphodiesterase
I33_RS01245	COG2271	Major facilitator Superfamily
I33_RS01255	COG0456	acetyltransferase
I33_RS01255	COG1846	Transcriptional regulator
I33_RS01260	COG2271	Major facilitator Superfamily
I33_RS01270	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS01275	COG0697	spore germination
I33_RS01280	COG2207	Transcriptional regulator
I33_RS01280	COG1917	Cupin 2, conserved barrel domain protein
I33_RS01285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I33_RS01290	COG3591	Belongs to the peptidase S1B family
I33_RS01300	COG0596	Alpha beta hydrolase
I33_RS01305	COG1183	phosphatidylcholine synthase activity
I33_RS01310	COG0586	Pfam SNARE associated Golgi protein
I33_RS01315	COG0688	phosphatidylethanolamine metabolic process
I33_RS01325	COG2312	Erythromycin esterase
I33_RS01330	COG1054	Belongs to the UPF0176 family
I33_RS01335	COG1301	dicarboxylic acid transport
I33_RS01340	COG1263	PTS System
I33_RS01340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS01340	COG2190	(PTS) system
I33_RS01345	COG0363	glucosamine-6-phosphate deaminase activity
I33_RS01350	COG2188	Transcriptional regulator
I33_RS01360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_RS01365	COG0833	amino acid
I33_RS01370	COG2040	homocysteine
I33_RS01380	COG1115	amino acid carrier protein
I33_RS01385	COG2066	Belongs to the glutaminase family
I33_RS01390	COG4191	Histidine kinase
I33_RS01395	COG0784	Response regulator, receiver
I33_RS01400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I33_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS01410	COG2271	Major facilitator Superfamily
I33_RS01415	COG4948	Mandelate Racemase Muconate Lactonizing
I33_RS01420	COG2186	Transcriptional regulator
I33_RS01425	COG2721	sulfolactate sulfo-lyase activity
I33_RS01430	COG3173	Aminoglycoside phosphotransferase
I33_RS01440	COG0697	spore germination
I33_RS01455	COG3773	Cell wall hydrolase
I33_RS01460	COG2304	oxidoreductase activity
I33_RS01465	COG3540	Alkaline phosphatase
I33_RS01470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_RS01475	COG0805	protein transport
I33_RS01480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I33_RS01485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I33_RS01490	COG0477	Major facilitator Superfamily
I33_RS01495	COG1309	transcriptional regulator
I33_RS01500	COG0252	asparaginase activity
I33_RS01505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I33_RS01510	COG1714	RDD family
I33_RS01515	COG3012	SEC-C Motif Domain Protein
I33_RS01515	COG1405	negative regulation of cell septum assembly
I33_RS01520	COG3290	protein histidine kinase activity
I33_RS01525	COG3279	Response regulator of the LytR AlgR family
I33_RS01530	COG4555	ABC transporter
I33_RS01535	COG1668	transmembrane transport
I33_RS01540	COG0667	Aldo Keto reductase
I33_RS01550	COG1595	DNA-templated transcription, initiation
I33_RS01555	COG1595	DNA-templated transcription, initiation
I33_RS01560	COG1876	peptidase activity
I33_RS01565	COG0457	Tetratricopeptide repeat
I33_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS01575	COG0366	Alpha amylase catalytic
I33_RS01580	COG0803	Belongs to the bacterial solute-binding protein 9 family
I33_RS01585	COG1121	(ABC) transporter
I33_RS01590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_RS01595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_RS01600	COG2310	stress, protein
I33_RS01605	COG2310	stress, protein
I33_RS01610	COG2310	stress, protein
I33_RS01615	COG0861	Integral membrane protein TerC family
I33_RS01625	COG3853	Toxic anion resistance protein (TelA)
I33_RS01630	COG0477	Major facilitator Superfamily
I33_RS01635	COG2814	Major facilitator Superfamily
I33_RS01640	COG0640	Transcriptional regulator
I33_RS01645	COG0517	IMP dehydrogenase activity
I33_RS01645	COG4175	Glycine betaine
I33_RS01650	COG4176	ABC-type proline glycine betaine transport system permease component
I33_RS01655	COG2113	Glycine betaine
I33_RS01660	COG1473	amidohydrolase
I33_RS01665	COG1288	antiporter activity
I33_RS01695	COG0366	Alpha amylase catalytic
I33_RS01700	COG0039	L-malate dehydrogenase activity
I33_RS01705	COG1620	l-lactate permease
I33_RS01710	COG2814	Major facilitator Superfamily
I33_RS01715	COG1846	Transcriptional regulator
I33_RS01720	COG1280	lysine exporter protein (LysE YggA)
I33_RS01725	COG3403	YqcI/YcgG family
I33_RS01730	COG1113	amino acid transport
I33_RS01735	COG3665	Urea carboxylase-associated protein
I33_RS01740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I33_RS01745	COG1660	Displays ATPase and GTPase activities
I33_RS01750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I33_RS01755	COG2226	methyltransferase
I33_RS01760	COG0583	DNA-binding transcription factor activity
I33_RS01765	COG3458	cephalosporin-C deacetylase activity
I33_RS01770	COG3541	Predicted nucleotidyltransferase
I33_RS01775	COG0506	proline dehydrogenase activity
I33_RS01780	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS01785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_RS01790	COG2508	Transcriptional regulator
I33_RS01795	COG3689	TIGRFAM TIGR03943 family protein
I33_RS01800	COG0701	Predicted permease
I33_RS01805	COG2267	carboxylic ester hydrolase activity
I33_RS01810	COG0492	ferredoxin-NADP+ reductase activity
I33_RS01815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I33_RS01815	COG1587	Uroporphyrinogen-III synthase
I33_RS01820	COG2146	nitrite reductase [NAD(P)H] activity
I33_RS01825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_RS01830	COG0243	molybdopterin cofactor binding
I33_RS01835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_RS01840	COG2223	nitrite transmembrane transporter activity
I33_RS01845	COG1469	GTP cyclohydrolase I activity
I33_RS01850	COG1376	ErfK ybiS ycfS ynhG family protein
I33_RS01860	COG0523	cobalamin synthesis protein
I33_RS01865	COG0765	amino acid transport
I33_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_RS01875	COG1714	RDD family
I33_RS01885	COG1846	Transcriptional regulator
I33_RS01900	COG2723	6-phospho-beta-galactosidase activity
I33_RS01910	COG3209	COG3209 Rhs family protein
I33_RS01915	COG3290	protein histidine kinase activity
I33_RS01915	COG0840	transmembrane signaling receptor activity
I33_RS01920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I33_RS01925	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I33_RS01930	COG1733	regulation of RNA biosynthetic process
I33_RS01935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS01940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS01945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS01950	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I33_RS01955	COG2814	Major facilitator Superfamily
I33_RS01965	COG0697	spore germination
I33_RS01970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS01980	COG2364	Membrane
I33_RS01985	COG1126	abc transporter atp-binding protein
I33_RS01990	COG0765	amino acid transport
I33_RS01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_RS02000	COG0583	DNA-binding transcription factor activity
I33_RS02005	COG0163	prenyltransferase activity
I33_RS02010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I33_RS02025	COG0596	Alpha beta hydrolase
I33_RS02030	COG3104	oligopeptide transport
I33_RS02035	COG5434	Belongs to the glycosyl hydrolase 28 family
I33_RS02045	COG0697	spore germination
I33_RS02055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I33_RS02060	COG1136	(ABC) transporter
I33_RS02065	COG0577	efflux transmembrane transporter activity
I33_RS02070	COG0745	RESPONSE REGULATOR receiver
I33_RS02075	COG5002	protein histidine kinase activity
I33_RS02075	COG3850	Histidine kinase
I33_RS02080	COG0457	Tetratricopeptide repeat
I33_RS02100	COG0527	aspartate kinase activity
I33_RS02105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS02110	COG4605	iron ion homeostasis
I33_RS02115	COG4604	ABC transporter, ATP-binding protein
I33_RS02120	COG4607	ABC-type enterochelin transport system periplasmic component
I33_RS02130	COG2814	Major facilitator Superfamily
I33_RS02135	COG1309	transcriptional regulator
I33_RS02140	COG0778	Nitroreductase
I33_RS02145	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I33_RS02150	COG0640	Transcriptional regulator
I33_RS02155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS02160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I33_RS02165	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS02170	COG4975	Glucose uptake
I33_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS02180	COG4549	nuclear export factor GLE1
I33_RS02185	COG2372	response to copper ion
I33_RS02185	COG1276	copper resistance
I33_RS02190	COG1349	DNA-binding transcription factor activity
I33_RS02210	COG2213	PTS system mannitol-specific
I33_RS02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS02220	COG0246	Mannitol dehydrogenase
I33_RS02225	COG0473	3-isopropylmalate dehydrogenase activity
I33_RS02230	COG0681	Belongs to the peptidase S26 family
I33_RS02235	COG0412	Dienelactone hydrolase
I33_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I33_RS02245	COG0561	phosphatase activity
I33_RS02250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I33_RS02255	COG1914	H( )-stimulated, divalent metal cation uptake system
I33_RS02260	COG4336	lyase activity
I33_RS02265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I33_RS02270	COG1984	allophanate hydrolase subunit 2
I33_RS02275	COG1414	Transcriptional regulator
I33_RS02280	COG2755	lipolytic protein G-D-S-L family
I33_RS02290	COG2329	Antibiotic biosynthesis monooxygenase
I33_RS02295	COG0768	penicillin binding
I33_RS02300	COG4989	oxidoreductase activity
I33_RS02305	COG3711	transcriptional antiterminator
I33_RS02310	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS02315	COG2226	methyltransferase
I33_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS02325	COG1917	Cupin 2, conserved barrel domain protein
I33_RS02330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS02335	COG3871	stress protein (general stress protein 26)
I33_RS02345	COG2814	Major facilitator Superfamily
I33_RS02350	COG1522	sequence-specific DNA binding
I33_RS02355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I33_RS02355	COG0551	DNA topoisomerase type I activity
I33_RS02360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I33_RS02365	COG3706	GGDEF domain
I33_RS02370	COG5298	Protein conserved in bacteria
I33_RS02375	COG1215	transferase activity, transferring glycosyl groups
I33_RS02385	COG0531	amino acid
I33_RS02395	COG0028	Belongs to the TPP enzyme family
I33_RS02405	COG1914	H( )-stimulated, divalent metal cation uptake system
I33_RS02410	COG2261	transglycosylase associated protein
I33_RS02415	COG4876	unkown
I33_RS02420	COG2217	Heavy metal translocating P-type atpase
I33_RS02425	COG3729	General stress protein
I33_RS02430	COG0662	Cupin 2, conserved barrel domain protein
I33_RS02435	COG2329	Antibiotic biosynthesis monooxygenase
I33_RS02440	COG3546	catalase activity
I33_RS02445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I33_RS02450	COG3290	protein histidine kinase activity
I33_RS02455	COG4565	transcriptional regulatory protein
I33_RS02460	COG1301	dicarboxylic acid transport
I33_RS02465	COG0628	permease
I33_RS02470	COG1131	(ABC) transporter
I33_RS02475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_RS02485	COG1960	acyl-CoA dehydrogenase activity
I33_RS02490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_RS02495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS02500	COG1181	Belongs to the D-alanine--D-alanine ligase family
I33_RS02505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I33_RS02510	COG0513	Belongs to the DEAD box helicase family
I33_RS02515	COG3402	PFAM membrane-flanked domain
I33_RS02520	COG3428	Bacterial PH domain
I33_RS02525	COG0705	Rhomboid family
I33_RS02530	COG0736	holo-[acyl-carrier-protein] synthase activity
I33_RS02535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I33_RS02540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I33_RS02545	COG0864	Transcriptional regulator
I33_RS02550	COG2337	Toxic component of a toxin-antitoxin (TA) module
I33_RS02555	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS02560	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS02565	COG2172	sigma factor antagonist activity
I33_RS02570	COG2208	phosphoserine phosphatase activity
I33_RS02575	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS02580	COG2172	sigma factor antagonist activity
I33_RS02585	COG1191	sigma factor activity
I33_RS02590	COG2208	phosphoserine phosphatase activity
I33_RS02600	COG1673	EVE domain
I33_RS02605	COG1846	Transcriptional regulator
I33_RS02610	COG2183	response to ionizing radiation
I33_RS02615	COG3091	SprT-like family
I33_RS02660	COG1522	sequence-specific DNA binding
I33_RS02665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_RS02670	COG2814	Major facilitator Superfamily
I33_RS02685	COG5444	nuclease activity
I33_RS02695	COG1476	TRANSCRIPTIONal
I33_RS02705	COG3239	Fatty acid desaturase
I33_RS02710	COG1278	Cold shock
I33_RS02715	COG1329	Transcriptional regulator
I33_RS02725	COG2807	transmembrane transport
I33_RS02730	COG1917	Cupin 2, conserved barrel domain protein
I33_RS02730	COG2207	Transcriptional regulator
I33_RS02735	COG0697	spore germination
I33_RS02740	COG3708	Transcriptional regulator
I33_RS02740	COG2207	Transcriptional regulator
I33_RS02750	COG0477	Major facilitator Superfamily
I33_RS02760	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I33_RS02785	COG0583	DNA-binding transcription factor activity
I33_RS02790	COG0114	fumarate hydratase activity
I33_RS02795	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_RS02800	COG1522	sequence-specific DNA binding
I33_RS02805	COG0697	spore germination
I33_RS02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS02815	COG2030	dehydratase
I33_RS02820	COG3545	Serine hydrolase
I33_RS02825	COG1733	regulation of RNA biosynthetic process
I33_RS02830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS02835	COG0640	Transcriptional regulator
I33_RS02840	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I33_RS02845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_RS02850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS02855	COG1316	TRANSCRIPTIONal
I33_RS02870	COG5002	protein histidine kinase activity
I33_RS02875	COG0745	RESPONSE REGULATOR receiver
I33_RS02880	COG0697	spore germination
I33_RS02885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS02890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I33_RS02895	COG0640	Transcriptional regulator
I33_RS02900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_RS02910	COG4585	Histidine kinase
I33_RS02915	COG2197	response regulator
I33_RS02920	COG2409	Drug exporters of the RND superfamily
I33_RS02925	COG1811	Na channel or pump
I33_RS02930	COG4978	Transcriptional regulator
I33_RS02930	COG0789	Transcriptional regulator
I33_RS02935	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_RS02940	COG0778	Nitroreductase
I33_RS02945	COG0346	lactoylglutathione lyase activity
I33_RS02950	COG2259	Doxx family
I33_RS02955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS02975	COG2323	membrane
I33_RS02980	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_RS02995	COG1309	transcriptional regulator
I33_RS03005	COG0456	acetyltransferase
I33_RS03015	COG0673	inositol 2-dehydrogenase activity
I33_RS03020	COG1609	Transcriptional regulator
I33_RS03025	COG2814	Major facilitator Superfamily
I33_RS03030	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS03035	COG0488	(ABC) transporter
I33_RS03040	COG1113	amino acid transport
I33_RS03045	COG2318	DinB family
I33_RS03050	COG1846	Transcriptional regulator
I33_RS03055	COG1033	growth of symbiont in host cell
I33_RS03055	COG2409	Drug exporters of the RND superfamily
I33_RS03060	COG0778	Nitroreductase
I33_RS03065	COG1846	Transcriptional regulator
I33_RS03070	COG2814	Major facilitator Superfamily
I33_RS03075	COG0730	response to heat
I33_RS03080	COG1802	Transcriptional regulator
I33_RS03085	COG3858	chitin binding
I33_RS03085	COG1388	LysM domain
I33_RS03090	COG1819	glycosyl
I33_RS03100	COG1785	Belongs to the alkaline phosphatase family
I33_RS03105	COG5646	InterPro IPR014922
I33_RS03115	COG0454	-acetyltransferase
I33_RS03120	COG1078	dGTPase activity
I33_RS03125	COG1388	LysM domain
I33_RS03130	COG2814	Major facilitator Superfamily
I33_RS03135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_RS03140	COG1447	Phosphotransferase system cellobiose-specific component IIA
I33_RS03145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_RS03150	COG2723	6-phospho-beta-galactosidase activity
I33_RS03155	COG2188	Transcriptional regulator
I33_RS03160	COG1940	carbohydrate kinase activity
I33_RS03165	COG1482	cell wall glycoprotein biosynthetic process
I33_RS03170	COG4124	Belongs to the glycosyl hydrolase 26 family
I33_RS03215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I33_RS03220	COG0802	atpase or kinase
I33_RS03225	COG1214	PFAM Peptidase M22, glycoprotease
I33_RS03230	COG0456	acetyltransferase
I33_RS03235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I33_RS03240	COG0488	(ABC) transporter
I33_RS03245	COG0315	cyclic pyranopterin monophosphate synthase activity
I33_RS03250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I33_RS03255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_RS03260	COG0805	protein transport
I33_RS03270	COG1266	CAAX protease self-immunity
I33_RS03280	COG0459	protein refolding
I33_RS03285	COG1073	alpha beta
I33_RS03290	COG0457	Tetratricopeptide repeat
I33_RS03295	COG1063	alcohol dehydrogenase
I33_RS03300	COG2211	Major facilitator Superfamily
I33_RS03305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_RS03315	COG2814	Major facilitator Superfamily
I33_RS03320	COG1063	alcohol dehydrogenase
I33_RS03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I33_RS03330	COG0823	Involved in the tonB-independent uptake of proteins
I33_RS03340	COG2267	carboxylic ester hydrolase activity
I33_RS03350	COG2132	Multicopper oxidase
I33_RS03355	COG1113	amino acid transport
I33_RS03360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I33_RS03365	COG0714	Associated with various cellular activities
I33_RS03370	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I33_RS03375	COG1305	Transglutaminase-like
I33_RS03380	COG0519	Catalyzes the synthesis of GMP from XMP
I33_RS03380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I33_RS03395	COG2252	PERMEase
I33_RS03400	COG3064	Membrane
I33_RS03405	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I33_RS03415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I33_RS03420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I33_RS03425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I33_RS03430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I33_RS03435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I33_RS03440	COG0047	phosphoribosylformylglycinamidine synthase activity
I33_RS03445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I33_RS03450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I33_RS03455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I33_RS03460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I33_RS03465	COG0138	bifunctional purine biosynthesis protein purh
I33_RS03470	COG0151	Belongs to the GarS family
I33_RS03475	COG1522	sequence-specific DNA binding
I33_RS03480	COG0531	amino acid
I33_RS03490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I33_RS03495	COG1470	cell adhesion involved in biofilm formation
I33_RS03500	COG4496	protein, YerC YecD
I33_RS03505	COG0069	glutamate synthase activity
I33_RS03510	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I33_RS03515	COG0210	DNA helicase
I33_RS03520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I33_RS03525	COG4851	CamS sex pheromone cAM373 precursor
I33_RS03530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_RS03535	COG1285	pathogenesis
I33_RS03540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_RS03545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I33_RS03550	COG0154	amidase activity
I33_RS03555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I33_RS03560	COG1309	transcriptional regulator
I33_RS03565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I33_RS03570	COG1597	lipid kinase activity
I33_RS03575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I33_RS03580	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I33_RS03590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I33_RS03610	COG5444	nuclease activity
I33_RS03615	COG3391	amine dehydrogenase activity
I33_RS03625	COG0457	Tetratricopeptide repeat
I33_RS03635	COG0217	transcriptional regulatory protein
I33_RS03645	COG1309	transcriptional regulator
I33_RS03650	COG3631	Ketosteroid isomerase-related protein
I33_RS03655	COG0702	epimerase
I33_RS03670	COG3546	catalase activity
I33_RS03675	COG0454	-acetyltransferase
I33_RS03685	COG5578	integral membrane protein
I33_RS03690	COG2972	Histidine kinase
I33_RS03695	COG2207	Transcriptional regulator
I33_RS03695	COG4753	response regulator
I33_RS03700	COG1653	transport
I33_RS03705	COG1175	transmembrane transport
I33_RS03710	COG0395	ABC-type sugar transport system, permease component
I33_RS03715	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I33_RS03720	COG2207	Transcriptional regulator
I33_RS03725	COG2755	lipolytic protein G-D-S-L family
I33_RS03735	COG5578	integral membrane protein
I33_RS03740	COG3401	FG-GAP repeat protein
I33_RS03745	COG3401	FG-GAP repeat protein
I33_RS03750	COG2755	lipolytic protein G-D-S-L family
I33_RS03755	COG1874	Beta-galactosidase
I33_RS03765	COG1653	transport
I33_RS03770	COG4209	transmembrane transport
I33_RS03775	COG0395	ABC-type sugar transport system, permease component
I33_RS03780	COG1486	melibiose metabolic process
I33_RS03785	COG2323	membrane
I33_RS03790	COG2329	Antibiotic biosynthesis monooxygenase
I33_RS03795	COG0346	lactoylglutathione lyase activity
I33_RS03810	COG0670	Belongs to the BI1 family
I33_RS03815	COG0697	spore germination
I33_RS03820	COG1846	Transcriptional regulator
I33_RS03825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I33_RS03835	COG2124	cytochrome p450
I33_RS03835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_RS03840	COG1368	sulfuric ester hydrolase activity
I33_RS03845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I33_RS03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_RS03855	COG1442	glycosyl transferase family 8
I33_RS03860	COG1216	Glycosyl transferase, family 2
I33_RS03865	COG1442	glycosyl transferase family 8
I33_RS03870	COG2223	nitrite transmembrane transporter activity
I33_RS03875	COG1011	Hydrolase
I33_RS03880	COG0531	amino acid
I33_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS03890	COG0840	transmembrane signaling receptor activity
I33_RS03895	COG0488	(ABC) transporter
I33_RS03905	COG0789	Transcriptional regulator
I33_RS03910	COG2814	Major facilitator Superfamily
I33_RS03920	COG0488	(ABC) transporter
I33_RS03925	COG0513	Belongs to the DEAD box helicase family
I33_RS03930	COG0456	acetyltransferase
I33_RS03935	COG2130	NADP-dependent
I33_RS03940	COG1120	ATPase activity
I33_RS03945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS03950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS03955	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I33_RS03970	COG3866	Pectate lyase
I33_RS03975	COG0471	metal ion transport
I33_RS03995	COG0457	Tetratricopeptide repeat
I33_RS03995	COG0463	Glycosyl transferase, family 2
I33_RS04000	COG1215	transferase activity, transferring glycosyl groups
I33_RS04005	COG3290	protein histidine kinase activity
I33_RS04010	COG4565	transcriptional regulatory protein
I33_RS04015	COG3181	Tripartite tricarboxylate transporter family receptor
I33_RS04020	COG2851	Citrate transporter
I33_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS04030	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I33_RS04035	COG1254	Belongs to the acylphosphatase family
I33_RS04040	COG2258	MOSC domain
I33_RS04050	COG0024	Methionine aminopeptidase
I33_RS04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS04055	COG1263	PTS System
I33_RS04060	COG1368	sulfuric ester hydrolase activity
I33_RS04070	COG1115	amino acid carrier protein
I33_RS04075	COG0531	amino acid
I33_RS04090	COG0697	spore germination
I33_RS04095	COG1263	PTS System
I33_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS04100	COG0366	Alpha amylase catalytic
I33_RS04105	COG2188	Transcriptional regulator
I33_RS04110	COG0778	Nitroreductase
I33_RS04115	COG0737	Belongs to the 5'-nucleotidase family
I33_RS04120	COG0693	protein deglycase activity
I33_RS04125	COG2814	Major facilitator Superfamily
I33_RS04130	COG4840	Belongs to the UPF0435 family
I33_RS04135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_RS04140	COG4980	gas vesicle protein
I33_RS04145	COG1295	ribonuclease BN
I33_RS04150	COG0477	Major facilitator Superfamily
I33_RS04155	COG0387	Pfam Sodium calcium exchanger
I33_RS04165	COG0668	transmembrane transport
I33_RS04170	COG0535	radical SAM domain protein
I33_RS04180	COG0726	polysaccharide deacetylase
I33_RS04185	COG2084	Dehydrogenase
I33_RS04190	COG0598	Magnesium transport protein CorA
I33_RS04195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I33_RS04200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I33_RS04210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I33_RS04215	COG4637	Psort location Cytoplasmic, score
I33_RS04220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_RS04225	COG0022	dehydrogenase e1 component
I33_RS04230	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_RS04235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_RS04240	COG3284	Transcriptional regulator
I33_RS04250	COG1742	UPF0060 membrane protein
I33_RS04275	COG4842	Belongs to the WXG100 family
I33_RS04315	COG1486	melibiose metabolic process
I33_RS04320	COG1737	Transcriptional regulator
I33_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS04325	COG1263	PTS System
I33_RS04330	COG1132	(ABC) transporter
I33_RS04335	COG1132	(ABC) transporter
I33_RS04340	COG2259	Doxx family
I33_RS04345	COG2514	catechol 2,3-dioxygenase activity
I33_RS04350	COG1917	Cupin 2, conserved barrel domain protein
I33_RS04350	COG4977	sequence-specific DNA binding
I33_RS04355	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS04360	COG0673	inositol 2-dehydrogenase activity
I33_RS04365	COG4585	Histidine kinase
I33_RS04370	COG2197	response regulator
I33_RS04375	COG1131	(ABC) transporter
I33_RS04380	COG0842	Transport permease protein
I33_RS04380	COG1511	domain protein
I33_RS04385	COG0842	Transport permease protein
I33_RS04395	COG1695	Transcriptional regulator
I33_RS04400	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I33_RS04405	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I33_RS04410	COG2318	DinB family
I33_RS04415	COG2814	Major facilitator Superfamily
I33_RS04420	COG1846	Transcriptional regulator
I33_RS04425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I33_RS04425	COG0392	lysyltransferase activity
I33_RS04430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS04435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS04440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS04445	COG0384	phenazine biosynthesis protein PhzF
I33_RS04450	COG0778	Nitroreductase
I33_RS04460	COG1090	epimerase
I33_RS04465	COG2137	regulation of response to DNA damage stimulus
I33_RS04475	COG2814	Major facilitator Superfamily
I33_RS04490	COG3103	Sh3 type 3 domain protein
I33_RS04495	COG5658	integral membrane protein
I33_RS04500	COG0596	Alpha beta hydrolase
I33_RS04505	COG0463	Glycosyl transferase, family 2
I33_RS04510	COG4485	Bacterial membrane protein, YfhO
I33_RS04515	COG1988	membrane-bound metal-dependent
I33_RS04520	COG1194	a g-specific adenine glycosylase
I33_RS04530	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS04545	COG3557	Belongs to the UPF0374 family
I33_RS04550	COG1132	(ABC) transporter
I33_RS04555	COG4129	membrane
I33_RS04560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I33_RS04565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I33_RS04570	COG0735	belongs to the Fur family
I33_RS04680	COG4326	sporulation control protein
I33_RS04690	COG3340	Belongs to the peptidase S51 family
I33_RS04695	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I33_RS04705	COG0753	catalase activity
I33_RS04710	COG1116	anion transmembrane transporter activity
I33_RS04715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I33_RS04720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I33_RS04725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_RS04735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I33_RS04745	COG1476	TRANSCRIPTIONal
I33_RS04755	COG3382	B3 4 domain protein
I33_RS04760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I33_RS04770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I33_RS04775	COG0789	Transcriptional regulator
I33_RS04780	COG1664	Polymer-forming cytoskeletal
I33_RS04785	COG1664	Polymer-forming cytoskeletal
I33_RS04790	COG2766	serine protein kinase
I33_RS04795	COG2718	Belongs to the UPF0229 family
I33_RS04800	COG1846	Transcriptional regulator
I33_RS04805	COG1566	PFAM secretion protein HlyD family protein
I33_RS04810	COG2814	Major facilitator Superfamily
I33_RS04815	COG0655	NAD(P)H dehydrogenase (quinone) activity
I33_RS04830	COG1725	Transcriptional regulator
I33_RS04835	COG1131	(ABC) transporter
I33_RS04840	COG1131	(ABC) transporter
I33_RS04845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_RS04850	COG1278	Cold shock
I33_RS04860	COG1464	Belongs to the NlpA lipoprotein family
I33_RS04865	COG3706	GGDEF domain
I33_RS04870	COG1823	symporter activity
I33_RS04890	COG5577	PFAM Coat F domain
I33_RS04895	COG0737	Belongs to the 5'-nucleotidase family
I33_RS04895	COG4085	toxin activity
I33_RS04895	COG1525	nuclease
I33_RS04900	COG3764	Sortase (surface protein transpeptidase)
I33_RS04905	COG0564	pseudouridine synthase activity
I33_RS04915	COG0517	IMP dehydrogenase activity
I33_RS04920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I33_RS04925	COG3153	acetyltransferase
I33_RS04925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I33_RS04930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_RS04935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I33_RS04940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I33_RS04945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I33_RS04950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I33_RS04955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I33_RS04960	COG4585	Histidine kinase
I33_RS04960	COG2203	Gaf domain
I33_RS04965	COG2197	response regulator
I33_RS04970	COG0431	NADPH-dependent FMN reductase
I33_RS04985	COG1388	LysM domain
I33_RS04985	COG0791	NLP P60 protein
I33_RS04990	COG1959	2 iron, 2 sulfur cluster binding
I33_RS04995	COG0668	transmembrane transport
I33_RS05000	COG2719	SpoVR family
I33_RS05005	COG1785	Belongs to the alkaline phosphatase family
I33_RS05010	COG0791	NLP P60 protein
I33_RS05010	COG1388	LysM domain
I33_RS05015	COG0583	DNA-binding transcription factor activity
I33_RS05020	COG0372	Belongs to the citrate synthase family
I33_RS05025	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS05030	COG0531	amino acid
I33_RS05035	COG0733	neurotransmitter:sodium symporter activity
I33_RS05040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS05045	COG0456	acetyltransferase
I33_RS05060	COG1595	DNA-templated transcription, initiation
I33_RS05065	COG0667	Aldo Keto reductase
I33_RS05070	COG0204	Acyl-transferase
I33_RS05075	COG1253	flavin adenine dinucleotide binding
I33_RS05080	COG0789	Transcriptional regulator
I33_RS05085	COG0436	Aminotransferase
I33_RS05090	COG1253	flavin adenine dinucleotide binding
I33_RS05095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I33_RS05100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I33_RS05105	COG0584	glycerophosphoryl diester phosphodiesterase
I33_RS05110	COG0668	transmembrane transport
I33_RS05115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I33_RS05120	COG0726	polysaccharide deacetylase
I33_RS05125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_RS05130	COG1757	Na H antiporter
I33_RS05135	COG0589	response to stress
I33_RS05145	COG1132	(ABC) transporter
I33_RS05150	COG1132	(ABC) transporter
I33_RS05155	COG0702	epimerase
I33_RS05170	COG0189	ligase activity
I33_RS05175	COG0189	ligase activity
I33_RS05180	COG4399	Belongs to the UPF0754 family
I33_RS05185	COG3679	Belongs to the UPF0342 family
I33_RS05190	COG4335	DNA alkylation repair
I33_RS05195	COG0561	phosphatase activity
I33_RS05200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I33_RS05205	COG0475	glutathione-regulated potassium exporter activity
I33_RS05210	COG0490	domain, Protein
I33_RS05220	COG1024	Enoyl-CoA hydratase
I33_RS05230	COG4152	abc transporter atp-binding protein
I33_RS05235	COG1668	transmembrane transport
I33_RS05245	COG0420	3'-5' exonuclease activity
I33_RS05250	COG4717	serine-type aminopeptidase activity
I33_RS05255	COG3481	metal-dependent phosphohydrolase, HD sub domain
I33_RS05265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I33_RS05290	COG1846	Transcriptional regulator
I33_RS05295	COG4980	gas vesicle protein
I33_RS05310	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I33_RS05315	COG0537	adenosine 5'-monophosphoramidase activity
I33_RS05320	COG1131	(ABC) transporter
I33_RS05325	COG4473	ABC transporter
I33_RS05335	COG1473	amidohydrolase
I33_RS05340	COG3069	C4-dicarboxylate transmembrane transporter activity
I33_RS05350	COG2329	Antibiotic biosynthesis monooxygenase
I33_RS05355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_RS05360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I33_RS05365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I33_RS05370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I33_RS05375	COG1309	transcriptional regulator
I33_RS05380	COG1511	domain protein
I33_RS05385	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_RS05390	COG4377	Putative membrane peptidase family (DUF2324)
I33_RS05400	COG1363	Peptidase, m42
I33_RS05405	COG4405	Protein conserved in bacteria
I33_RS05410	COG1301	dicarboxylic acid transport
I33_RS05420	COG1234	tRNA 3'-trailer cleavage
I33_RS05425	COG0095	Lipoate-protein ligase
I33_RS05430	COG0702	epimerase
I33_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS05445	COG0501	Belongs to the peptidase M48B family
I33_RS05450	COG1404	Belongs to the peptidase S8 family
I33_RS05455	COG0456	acetyltransferase
I33_RS05460	COG0604	alcohol dehydrogenase
I33_RS05465	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I33_RS05470	COG0406	alpha-ribazole phosphatase activity
I33_RS05475	COG0183	Belongs to the thiolase family
I33_RS05480	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS05485	COG1268	BioY protein
I33_RS05490	COG0840	transmembrane signaling receptor activity
I33_RS05495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_RS05495	COG0723	plastoquinol--plastocyanin reductase activity
I33_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS05510	COG4903	ComK protein
I33_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS05525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_RS05540	COG0398	Pfam SNARE associated Golgi protein
I33_RS05545	COG0681	Belongs to the peptidase S26 family
I33_RS05550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I33_RS05555	COG1846	Transcriptional regulator
I33_RS05560	COG0738	Major facilitator superfamily
I33_RS05565	COG0673	inositol 2-dehydrogenase activity
I33_RS05570	COG0561	phosphatase activity
I33_RS05575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_RS05580	COG1609	Transcriptional regulator
I33_RS05585	COG3180	Ammonia monooxygenase
I33_RS05590	COG2814	Major facilitator Superfamily
I33_RS05590	COG0477	Major facilitator Superfamily
I33_RS05595	COG4533	DNA binding
I33_RS05605	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I33_RS05610	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I33_RS05615	COG1074	ATP-dependent DNA helicase activity
I33_RS05620	COG0420	3'-5' exonuclease activity
I33_RS05625	COG0419	ATPase involved in DNA repair
I33_RS05630	COG1403	HNH endonuclease
I33_RS05670	COG5337	Spore coat protein CotH
I33_RS05675	COG0179	Fumarylacetoacetate (FAA) hydrolase
I33_RS05685	COG1404	Belongs to the peptidase S8 family
I33_RS05695	COG0367	asparagine synthase
I33_RS05700	COG1562	ergosterol biosynthetic process
I33_RS05705	COG0534	Mate efflux family protein
I33_RS05710	COG1917	Cupin 2, conserved barrel domain protein
I33_RS05710	COG2207	Transcriptional regulator
I33_RS05715	COG1609	Transcriptional regulator
I33_RS05720	COG0673	inositol 2-dehydrogenase activity
I33_RS05725	COG2318	DinB family
I33_RS05730	COG1279	arginine transmembrane transporter activity
I33_RS05735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I33_RS05740	COG1357	PFAM Pentapeptide repeats (8 copies)
I33_RS05745	COG2267	carboxylic ester hydrolase activity
I33_RS05750	COG0529	Catalyzes the synthesis of activated sulfate
I33_RS05755	COG2046	Belongs to the sulfate adenylyltransferase family
I33_RS05760	COG0175	sulfate reduction
I33_RS05765	COG2045	Belongs to the ComB family
I33_RS05770	COG1809	phosphosulfolactate synthase activity
I33_RS05775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS05780	COG4948	Mandelate Racemase Muconate Lactonizing
I33_RS05785	COG2814	Major facilitator Superfamily
I33_RS05790	COG0454	-acetyltransferase
I33_RS05795	COG2153	protein acetylation
I33_RS05800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I33_RS05800	COG0646	methionine synthase
I33_RS05805	COG1666	GTP binding
I33_RS05810	COG2996	Protein conserved in bacteria
I33_RS05820	COG1307	EDD domain protein, DegV family
I33_RS05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS05840	COG0561	phosphatase activity
I33_RS05845	COG1073	alpha beta
I33_RS05850	COG2151	metal-sulfur cluster biosynthetic enzyme
I33_RS05855	COG0277	FAD linked oxidase domain protein
I33_RS05860	COG2271	Major facilitator Superfamily
I33_RS05865	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I33_RS05870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I33_RS05880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I33_RS05885	COG0505	Belongs to the CarA family
I33_RS05890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I33_RS05895	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I33_RS05920	COG1744	ABC transporter substrate-binding protein PnrA-like
I33_RS05935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I33_RS05945	COG5504	Zn-dependent protease
I33_RS05950	COG0444	Belongs to the ABC transporter superfamily
I33_RS05955	COG4608	Belongs to the ABC transporter superfamily
I33_RS05965	COG0601	transmembrane transport
I33_RS05970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_RS05980	COG0180	Tryptophanyl-tRNA synthetase
I33_RS05985	COG4166	transmembrane transport
I33_RS05990	COG0601	transmembrane transport
I33_RS05995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_RS06000	COG0444	Belongs to the ABC transporter superfamily
I33_RS06005	COG4608	Belongs to the ABC transporter superfamily
I33_RS06010	COG2814	Major facilitator Superfamily
I33_RS06015	COG0456	acetyltransferase
I33_RS06020	COG1393	Belongs to the ArsC family
I33_RS06025	COG0861	Integral membrane protein TerC family
I33_RS06030	COG4862	establishment of competence for transformation
I33_RS06035	COG4469	Competence protein
I33_RS06040	COG1164	Oligoendopeptidase f
I33_RS06050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I33_RS06055	COG2346	COG2346, Truncated hemoglobins
I33_RS06060	COG0741	lytic transglycosylase activity
I33_RS06065	COG4116	CYTH
I33_RS06075	COG2357	RelA SpoT domain protein
I33_RS06080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I33_RS06085	COG0564	pseudouridine synthase activity
I33_RS06090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I33_RS06095	COG0569	domain protein
I33_RS06095	COG0475	glutathione-regulated potassium exporter activity
I33_RS06100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I33_RS06105	COG0352	thiamine-phosphate diphosphorylase activity
I33_RS06110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_RS06115	COG2104	thiamine diphosphate biosynthetic process
I33_RS06120	COG2022	thiamine diphosphate biosynthetic process
I33_RS06125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I33_RS06130	COG0351	phosphomethylpyrimidine kinase
I33_RS06135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I33_RS06190	COG0210	DNA helicase
I33_RS06200	COG2153	protein acetylation
I33_RS06205	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I33_RS06210	COG2382	esterase
I33_RS06215	COG0626	cystathionine gamma-synthase activity
I33_RS06220	COG0626	cystathionine gamma-synthase activity
I33_RS06225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS06245	COG0501	Belongs to the peptidase M48B family
I33_RS06270	COG4824	toxin secretion phage lysis holin
I33_RS06310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I33_RS06320	COG3711	transcriptional antiterminator
I33_RS06320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS06325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_RS06325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_RS06325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS06330	COG1482	cell wall glycoprotein biosynthetic process
I33_RS06340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS06350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I33_RS06365	COG0109	protoheme IX farnesyltransferase activity
I33_RS06375	COG0726	polysaccharide deacetylase
I33_RS06385	COG5504	Zn-dependent protease
I33_RS06390	COG2205	protein histidine kinase activity
I33_RS06400	COG3383	formate dehydrogenase (NAD+) activity
I33_RS06405	COG2427	Protein of unknown function (DUF1641)
I33_RS06415	COG1051	belongs to the nudix hydrolase family
I33_RS06425	COG2124	cytochrome p450
I33_RS06430	COG1819	glycosyl
I33_RS06440	COG1587	Uroporphyrinogen-III synthase
I33_RS06445	COG0390	transport system, permease component
I33_RS06450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_RS06455	COG0697	spore germination
I33_RS06460	COG4297	protein containing double-stranded beta helix domain
I33_RS06470	COG1252	NADH dehydrogenase
I33_RS06475	COG1904	glucuronate isomerase
I33_RS06480	COG2211	Major facilitator Superfamily
I33_RS06485	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I33_RS06490	COG1063	alcohol dehydrogenase
I33_RS06495	COG1312	Catalyzes the dehydration of D-mannonate
I33_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS06505	COG2271	Major facilitator Superfamily
I33_RS06510	COG1609	Transcriptional regulator
I33_RS06515	COG0246	Mannitol dehydrogenase
I33_RS06520	COG2721	sulfolactate sulfo-lyase activity
I33_RS06525	COG0730	response to heat
I33_RS06530	COG2318	DinB family
I33_RS06535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I33_RS06540	COG0457	Tetratricopeptide repeat
I33_RS06550	COG2350	Protein conserved in bacteria
I33_RS06555	COG1388	LysM domain
I33_RS06555	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS06555	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_RS06565	COG4195	phage-related replication protein
I33_RS06570	COG3546	catalase activity
I33_RS06575	COG2856	Zn peptidase
I33_RS06580	COG1396	sequence-specific DNA binding
I33_RS06590	COG1522	sequence-specific DNA binding
I33_RS06595	COG1484	DNA-dependent DNA replication
I33_RS06610	COG1595	DNA-templated transcription, initiation
I33_RS06615	COG3728	DNA packaging
I33_RS06615	COG5484	DNA packaging
I33_RS06620	COG1783	phage Terminase large subunit
I33_RS06625	COG5518	Phage portal protein
I33_RS06630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I33_RS06635	COG4653	Phage capsid family
I33_RS06680	COG5412	phage tail tape measure protein
I33_RS06680	COG3953	SLT domain
I33_RS06685	COG1652	LysM domain
I33_RS06690	COG4193	domain, Protein
I33_RS06700	COG3628	GPW Gp25 family protein
I33_RS06705	COG3299	homolog of phage Mu protein gp47
I33_RS06710	COG3778	Protein conserved in bacteria
I33_RS06750	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS06750	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_RS06765	COG0306	phosphate transporter
I33_RS06770	COG1392	Phosphate transport regulator
I33_RS06775	COG0531	amino acid
I33_RS06780	COG0346	lactoylglutathione lyase activity
I33_RS06785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I33_RS06790	COG0463	Glycosyl transferase, family 2
I33_RS06795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_RS06800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_RS06805	COG2362	D-Aminopeptidase
I33_RS06810	COG0601	transmembrane transport
I33_RS06815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I33_RS06820	COG0444	Belongs to the ABC transporter superfamily
I33_RS06825	COG4166	transmembrane transport
I33_RS06830	COG1619	proteins homologs of microcin C7 resistance protein MccF
I33_RS06835	COG4948	Mandelate Racemase Muconate Lactonizing
I33_RS06840	COG0791	NLP P60 protein
I33_RS06845	COG4608	Belongs to the ABC transporter superfamily
I33_RS06850	COG2706	6-phosphogluconolactonase activity
I33_RS06855	COG1834	amidinotransferase
I33_RS06860	COG1607	acyl-coa hydrolase
I33_RS06865	COG1017	nitric oxide dioxygenase activity
I33_RS06865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I33_RS06875	COG2323	membrane
I33_RS06880	COG2318	DinB family
I33_RS06885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS06890	COG2076	Multidrug Resistance protein
I33_RS06895	COG2076	Multidrug Resistance protein
I33_RS06900	COG0788	formyltetrahydrofolate deformylase activity
I33_RS06905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I33_RS06910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I33_RS06915	COG1764	response to oxidative stress
I33_RS06920	COG1846	Transcriptional regulator
I33_RS06925	COG1764	response to oxidative stress
I33_RS06930	COG0590	tRNA wobble adenosine to inosine editing
I33_RS06940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_RS06945	COG1404	Belongs to the peptidase S8 family
I33_RS06950	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS06955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I33_RS06960	COG1122	ATPase activity
I33_RS06965	COG4721	ABC-type cobalt transport system, permease component
I33_RS06975	COG0745	RESPONSE REGULATOR receiver
I33_RS06980	COG3850	Histidine kinase
I33_RS06980	COG5002	protein histidine kinase activity
I33_RS06985	COG3212	peptidase
I33_RS06990	COG3212	peptidase
I33_RS07000	COG2239	Acts as a magnesium transporter
I33_RS07005	COG0789	Transcriptional regulator
I33_RS07015	COG1846	Transcriptional regulator
I33_RS07020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_RS07025	COG0726	polysaccharide deacetylase
I33_RS07030	COG1408	metallophosphoesterase
I33_RS07040	COG0463	Glycosyl transferase, family 2
I33_RS07045	COG1793	dna ligase
I33_RS07045	COG3285	dna ligase
I33_RS07050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I33_RS07055	COG3300	MHYT domain
I33_RS07055	COG5001	Diguanylate cyclase
I33_RS07060	COG0586	Pfam SNARE associated Golgi protein
I33_RS07065	COG0861	Integral membrane protein TerC family
I33_RS07070	COG1191	sigma factor activity
I33_RS07090	COG0501	Belongs to the peptidase M48B family
I33_RS07095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I33_RS07100	COG3594	Acyltransferase
I33_RS07105	COG5002	protein histidine kinase activity
I33_RS07110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I33_RS07115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I33_RS07120	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I33_RS07125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I33_RS07130	COG0436	Aminotransferase
I33_RS07135	COG1850	ribulose-bisphosphate carboxylase activity
I33_RS07140	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I33_RS07145	COG0235	Class ii aldolase
I33_RS07150	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I33_RS07155	COG3339	Conserved Protein
I33_RS07170	COG3852	Histidine kinase
I33_RS07175	COG1846	Transcriptional regulator
I33_RS07180	COG1360	Flagellar Motor Protein
I33_RS07185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I33_RS07190	COG0542	response to heat
I33_RS07195	COG3949	Membrane
I33_RS07200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I33_RS07205	COG0720	synthase
I33_RS07210	COG0602	queuosine metabolic process
I33_RS07215	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I33_RS07220	COG1733	regulation of RNA biosynthetic process
I33_RS07225	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS07230	COG1388	LysM domain
I33_RS07230	COG4641	Protein conserved in bacteria
I33_RS07235	COG1388	LysM domain
I33_RS07240	COG3858	chitin binding
I33_RS07250	COG4873	Protein conserved in bacteria
I33_RS07260	COG3773	Cell wall hydrolase
I33_RS07265	COG2244	polysaccharide biosynthetic process
I33_RS07270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS07275	COG2217	Heavy metal translocating P-type atpase
I33_RS07285	COG0006	proline dipeptidase activity
I33_RS07290	COG1609	Transcriptional regulator
I33_RS07295	COG3711	transcriptional antiterminator
I33_RS07300	COG2190	(PTS) system
I33_RS07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS07300	COG1263	PTS System
I33_RS07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS07310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I33_RS07320	COG1533	DNA photolyase activity
I33_RS07325	COG0456	acetyltransferase
I33_RS07330	COG0840	transmembrane signaling receptor activity
I33_RS07335	COG2084	Dehydrogenase
I33_RS07340	COG2340	Cysteine-rich secretory protein family
I33_RS07345	COG0768	penicillin binding
I33_RS07350	COG4191	Histidine kinase
I33_RS07355	COG0436	Aminotransferase
I33_RS07360	COG0784	Response regulator, receiver
I33_RS07360	COG0835	chemotaxis
I33_RS07370	COG2814	Major facilitator Superfamily
I33_RS07375	COG1376	ErfK ybiS ycfS ynhG family protein
I33_RS07380	COG1408	metallophosphoesterase
I33_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS07390	COG2200	EAL domain
I33_RS07395	COG4703	Protein of unknown function (DUF1797)
I33_RS07400	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I33_RS07410	COG0517	IMP dehydrogenase activity
I33_RS07415	COG0583	DNA-binding transcription factor activity
I33_RS07420	COG0716	FMN binding
I33_RS07430	COG0716	FMN binding
I33_RS07435	COG2171	N-acyltransferase activity
I33_RS07440	COG1473	amidohydrolase
I33_RS07450	COG0668	transmembrane transport
I33_RS07455	COG0450	alkyl hydroperoxide reductase
I33_RS07460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS07475	COG0746	molybdenum cofactor guanylyltransferase activity
I33_RS07480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I33_RS07485	COG0303	'Molybdopterin
I33_RS07490	COG1763	Mo-molybdopterin cofactor biosynthetic process
I33_RS07495	COG0314	molybdopterin synthase activity
I33_RS07500	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I33_RS07505	COG1132	(ABC) transporter
I33_RS07510	COG1132	(ABC) transporter
I33_RS07520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I33_RS07525	COG1136	(ABC) transporter
I33_RS07530	COG0577	efflux transmembrane transporter activity
I33_RS07535	COG1349	DNA-binding transcription factor activity
I33_RS07540	COG1105	Belongs to the carbohydrate kinase PfkB family
I33_RS07545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS07545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_RS07545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I33_RS07550	COG0681	Belongs to the peptidase S26 family
I33_RS07560	COG0488	(ABC) transporter
I33_RS07565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I33_RS07570	COG2309	aminopeptidase activity
I33_RS07575	COG1077	Cell shape determining protein MreB Mrl
I33_RS07580	COG2002	toxin-antitoxin pair type II binding
I33_RS07585	COG3852	Histidine kinase
I33_RS07590	COG2105	PFAM AIG2 family protein
I33_RS07590	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I33_RS07595	COG0569	domain protein
I33_RS07600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I33_RS07605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I33_RS07610	COG5503	Protein of unknown function (DUF1447)
I33_RS07615	COG0561	phosphatase activity
I33_RS07620	COG0242	peptide deformylase activity
I33_RS07630	COG0497	DNA recombination
I33_RS07635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_RS07640	COG0022	dehydrogenase e1 component
I33_RS07645	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_RS07650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_RS07655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS07660	COG1982	Orn Lys Arg decarboxylase major
I33_RS07665	COG4476	Belongs to the UPF0223 family
I33_RS07670	COG4493	Belongs to the UPF0637 family
I33_RS07680	COG0483	inositol monophosphate 1-phosphatase activity
I33_RS07690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I33_RS07710	COG1595	DNA-templated transcription, initiation
I33_RS07730	COG1217	gtp-binding protein TYPA
I33_RS07740	COG4896	Protein conserved in bacteria
I33_RS07750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I33_RS07755	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I33_RS07760	COG2066	Belongs to the glutaminase family
I33_RS07765	COG4838	Belongs to the UPF0358 family
I33_RS07770	COG0772	Belongs to the SEDS family
I33_RS07775	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I33_RS07780	COG1612	heme a metabolic process
I33_RS07785	COG0109	protoheme IX farnesyltransferase activity
I33_RS07790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I33_RS07790	COG2010	Cytochrome c
I33_RS07795	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I33_RS07800	COG1845	cytochrome c oxidase, subunit III
I33_RS07805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I33_RS07810	COG3336	cytochrome c oxidase
I33_RS07820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I33_RS07825	COG2340	Cysteine-rich secretory protein family
I33_RS07840	COG3679	Belongs to the UPF0342 family
I33_RS07845	COG4471	UPF0298 protein
I33_RS07850	COG0742	ribosomal rna small subunit methyltransferase
I33_RS07855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I33_RS07860	COG3314	Sporulation integral membrane protein YlbJ
I33_RS07865	COG1752	Esterase of the alpha-beta hydrolase superfamily
I33_RS07870	COG3480	Lon protease (S16) C-terminal proteolytic domain
I33_RS07875	COG1323	Belongs to the UPF0348 family
I33_RS07885	COG1399	metal-binding, possibly nucleic acid-binding protein
I33_RS07895	COG0454	-acetyltransferase
I33_RS07900	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I33_RS07905	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I33_RS07910	COG2001	Belongs to the MraZ family
I33_RS07915	COG0275	rRNA processing
I33_RS07920	COG4839	cell division protein FtsL
I33_RS07925	COG0768	penicillin binding
I33_RS07930	COG0768	penicillin binding
I33_RS07935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I33_RS07940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I33_RS07945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I33_RS07950	COG0772	Belongs to the SEDS family
I33_RS07955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_RS07960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I33_RS07965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I33_RS07970	COG3879	Bacterial protein of unknown function (DUF881)
I33_RS07975	COG3879	Bacterial protein of unknown function (DUF881)
I33_RS07980	COG3856	small basic protein
I33_RS07985	COG0849	cell division
I33_RS07990	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I33_RS07995	COG1404	Belongs to the peptidase S8 family
I33_RS07995	COG4412	M6 family metalloprotease domain protein
I33_RS08005	COG1191	sigma factor activity
I33_RS08010	COG1191	sigma factor activity
I33_RS08015	COG1119	ATPase activity
I33_RS08020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_RS08025	COG1873	PFAM PRC-barrel domain
I33_RS08030	COG1496	oxidoreductase activity
I33_RS08035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I33_RS08040	COG1799	cell septum assembly
I33_RS08045	COG0762	integral membrane protein
I33_RS08050	COG2302	S4 RNA-binding domain
I33_RS08055	COG3599	regulation of cell shape
I33_RS08060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I33_RS08065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_RS08070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I33_RS08075	COG0564	pseudouridine synthase activity
I33_RS08080	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I33_RS08085	COG2233	PERMEase
I33_RS08090	COG0540	Belongs to the ATCase OTCase family
I33_RS08095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I33_RS08100	COG0505	Belongs to the CarA family
I33_RS08105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I33_RS08110	COG0543	2 iron, 2 sulfur cluster binding
I33_RS08115	COG0167	dihydroorotate dehydrogenase activity
I33_RS08120	COG0284	orotidine-5'-phosphate decarboxylase activity
I33_RS08125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I33_RS08130	COG0175	sulfate reduction
I33_RS08135	COG0306	phosphate transporter
I33_RS08140	COG2046	Belongs to the sulfate adenylyltransferase family
I33_RS08145	COG0529	Catalyzes the synthesis of activated sulfate
I33_RS08150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I33_RS08155	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I33_RS08160	COG1648	precorrin-2 dehydrogenase activity
I33_RS08165	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I33_RS08170	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I33_RS08175	COG1561	YicC-like family, N-terminal region
I33_RS08185	COG0194	GDP metabolic process
I33_RS08190	COG1758	RNA polymerase activity
I33_RS08195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I33_RS08200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I33_RS08205	COG0242	peptide deformylase activity
I33_RS08210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I33_RS08215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I33_RS08215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I33_RS08220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I33_RS08225	COG0631	protein serine/threonine phosphatase activity
I33_RS08230	COG0515	serine threonine protein kinase
I33_RS08230	COG2815	serine threonine protein kinase
I33_RS08235	COG1162	GTPase activity
I33_RS08240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I33_RS08245	COG1564	THIamine pyrophosphokinase
I33_RS08255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I33_RS08260	COG1302	Protein conserved in bacteria
I33_RS08265	COG1461	Dihydroxyacetone kinase
I33_RS08270	COG1760	l-serine dehydratase
I33_RS08275	COG1760	l-serine dehydratase
I33_RS08280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I33_RS08285	COG1349	DNA-binding transcription factor activity
I33_RS08285	COG2050	protein possibly involved in aromatic compounds catabolism
I33_RS08290	COG0416	fatty acid biosynthetic process
I33_RS08295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS08310	COG0571	ribonuclease III activity
I33_RS08315	COG1196	nuclear chromosome segregation
I33_RS08320	COG0552	protein localization to endoplasmic reticulum
I33_RS08330	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I33_RS08335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I33_RS08340	COG0228	four-way junction DNA binding
I33_RS08345	COG1837	Belongs to the UPF0109 family
I33_RS08355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I33_RS08360	COG0336	Belongs to the RNA methyltransferase TrmD family
I33_RS08365	COG0335	large ribosomal subunit rRNA binding
I33_RS08370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I33_RS08375	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I33_RS08385	COG2257	FlhB HrpN YscU SpaS Family
I33_RS08390	COG0045	succinate-CoA ligase (ADP-forming) activity
I33_RS08395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I33_RS08400	COG0758	DNA mediated transformation
I33_RS08405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I33_RS08410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I33_RS08415	COG4974	Belongs to the 'phage' integrase family
I33_RS08420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I33_RS08425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I33_RS08430	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I33_RS08435	COG1815	bacterial-type flagellum-dependent cell motility
I33_RS08440	COG1558	bacterial-type flagellum-dependent cell motility
I33_RS08445	COG1677	Flagellar hook-basal body complex protein FliE
I33_RS08450	COG1766	The M ring may be actively involved in energy transduction
I33_RS08455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_RS08460	COG1317	bacterial-type flagellum organization
I33_RS08465	COG1157	protein secretion by the type III secretion system
I33_RS08470	COG2882	bacterial-type flagellum organization
I33_RS08475	COG3334	PFAM MgtE intracellular
I33_RS08480	COG3144	bacterial-type flagellum assembly
I33_RS08485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I33_RS08490	COG4786	Flagellar basal body rod
I33_RS08495	COG1582	Flagellar protein (FlbD)
I33_RS08500	COG1580	Controls the rotational direction of flagella during chemotaxis
I33_RS08505	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_RS08510	COG1776	CheC inhibitor of MCP methylation
I33_RS08510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I33_RS08515	COG2201	protein-glutamate methylesterase activity
I33_RS08520	COG3190	flagellar
I33_RS08525	COG1338	Plays a role in the flagellum-specific transport system
I33_RS08530	COG1987	bacterial-type flagellum assembly
I33_RS08535	COG1684	flagellar biosynthetic protein fliR
I33_RS08540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I33_RS08545	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I33_RS08550	COG1419	protein localization to endoplasmic reticulum
I33_RS08555	COG0455	bacterial-type flagellum organization
I33_RS08560	COG2201	protein-glutamate methylesterase activity
I33_RS08565	COG2198	Histidine kinase
I33_RS08565	COG0643	Histidine kinase
I33_RS08570	COG0835	chemotaxis
I33_RS08575	COG1776	CheC inhibitor of MCP methylation
I33_RS08580	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I33_RS08585	COG1191	sigma factor activity
I33_RS08595	COG0052	Belongs to the universal ribosomal protein uS2 family
I33_RS08600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I33_RS08605	COG0528	UMP kinase activity
I33_RS08610	COG0233	cytoplasmic translational termination
I33_RS08615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I33_RS08620	COG4589	Belongs to the CDS family
I33_RS08625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I33_RS08630	COG0750	zinc metalloprotease
I33_RS08635	COG0442	prolyl-tRNA aminoacylation
I33_RS08640	COG2176	DNA-directed DNA polymerase activity
I33_RS08645	COG0779	Required for maturation of 30S ribosomal subunits
I33_RS08650	COG0195	Participates in both transcription termination and antitermination
I33_RS08655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I33_RS08660	COG1358	cellular component organization or biogenesis
I33_RS08665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I33_RS08670	COG1550	Protein conserved in bacteria
I33_RS08675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I33_RS08680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I33_RS08685	COG0196	riboflavin kinase activity
I33_RS08690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I33_RS08695	COG1185	polyribonucleotide nucleotidyltransferase activity
I33_RS08700	COG0726	polysaccharide deacetylase
I33_RS08705	COG0612	Peptidase, M16
I33_RS08710	COG1873	PFAM PRC-barrel domain
I33_RS08715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I33_RS08720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I33_RS08725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I33_RS08730	COG0527	aspartate kinase activity
I33_RS08735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I33_RS08740	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I33_RS08745	COG0740	serine-type endopeptidase activity
I33_RS08755	COG4980	gas vesicle protein
I33_RS08755	COG1674	ftsk spoiiie
I33_RS08760	COG2188	Transcriptional regulator
I33_RS08765	COG2814	Major facilitator Superfamily
I33_RS08770	COG0612	Peptidase, M16
I33_RS08775	COG0612	Peptidase, M16
I33_RS08780	COG0300	oxidoreductase activity
I33_RS08795	COG1426	Protein conserved in bacteria
I33_RS08800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I33_RS08805	COG1546	Belongs to the CinA family
I33_RS08805	COG1058	Belongs to the CinA family
I33_RS08810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I33_RS08815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_RS08820	COG1418	mRNA catabolic process
I33_RS08825	COG1692	metallophosphoesterase
I33_RS08830	COG2359	stage V sporulation protein S
I33_RS08835	COG1063	alcohol dehydrogenase
I33_RS08840	COG0156	8-amino-7-oxononanoate synthase activity
I33_RS08845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I33_RS08850	COG4550	Control of competence regulator ComK, YlbF/YmcA
I33_RS08860	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I33_RS08865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I33_RS08880	COG3226	Transcriptional regulator
I33_RS08885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS08895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_RS08900	COG3321	synthase
I33_RS08905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I33_RS08905	COG2070	2-Nitropropane dioxygenase
I33_RS08910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_RS08915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I33_RS08920	COG3425	synthase
I33_RS08925	COG1024	Enoyl-CoA hydratase
I33_RS08930	COG1024	Enoyl-CoA hydratase
I33_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS08935	COG3321	synthase
I33_RS08935	COG0300	oxidoreductase activity
I33_RS08935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS08940	COG3321	synthase
I33_RS08940	COG0300	oxidoreductase activity
I33_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_RS08940	COG4221	oxidoreductase activity
I33_RS08945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_RS08945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS08945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS08945	COG3321	synthase
I33_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS08950	COG3321	synthase
I33_RS08950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS08950	COG4221	oxidoreductase activity
I33_RS08955	COG3321	synthase
I33_RS08955	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I33_RS08955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I33_RS08955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_RS08960	COG2124	cytochrome p450
I33_RS08970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS08975	COG1404	Belongs to the peptidase S8 family
I33_RS08985	COG4195	phage-related replication protein
I33_RS08990	COG1764	response to oxidative stress
I33_RS08995	COG2076	Multidrug Resistance protein
I33_RS09000	COG2076	Multidrug Resistance protein
I33_RS09015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I33_RS09020	COG1923	regulation of RNA biosynthetic process
I33_RS09035	COG1780	Probably involved in ribonucleotide reductase function
I33_RS09040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I33_RS09045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I33_RS09050	COG4112	unkown
I33_RS09055	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS09060	COG0464	growth
I33_RS09065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I33_RS09070	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I33_RS09075	COG0789	Transcriptional regulator
I33_RS09080	COG0174	glutamine synthetase
I33_RS09095	COG4824	toxin secretion phage lysis holin
I33_RS09100	COG1388	LysM domain
I33_RS09100	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS09100	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_RS09105	COG1388	LysM domain
I33_RS09105	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS09105	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_RS09130	COG4282	regulation of fungal-type cell wall biogenesis
I33_RS09145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS09170	COG2211	Major facilitator Superfamily
I33_RS09175	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_RS09180	COG1940	carbohydrate kinase activity
I33_RS09185	COG2115	Belongs to the xylose isomerase family
I33_RS09190	COG1070	Carbohydrate kinase
I33_RS09195	COG1525	nuclease
I33_RS09200	COG2814	Major facilitator Superfamily
I33_RS09205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I33_RS09220	COG0756	dUTP diphosphatase activity
I33_RS09230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I33_RS09255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I33_RS09265	COG3832	glyoxalase III activity
I33_RS09280	COG0531	amino acid
I33_RS09310	COG4195	phage-related replication protein
I33_RS09320	COG0346	lactoylglutathione lyase activity
I33_RS09325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I33_RS09330	COG1388	LysM domain
I33_RS09335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I33_RS09340	COG4224	UPF0291 protein
I33_RS09345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I33_RS09355	COG3763	UPF0154 protein
I33_RS09365	COG0785	Cytochrome C biogenesis protein
I33_RS09370	COG2201	protein-glutamate methylesterase activity
I33_RS09375	COG4846	Membrane protein involved in cytochrome C biogenesis
I33_RS09385	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_RS09400	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I33_RS09405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS09425	COG0824	Thioesterase
I33_RS09435	COG4841	protein insertion into membrane
I33_RS09440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I33_RS09445	COG1832	CoA-binding protein
I33_RS09450	COG0187	DNA topoisomerase II activity
I33_RS09455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I33_RS09465	COG1115	amino acid carrier protein
I33_RS09470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
I33_RS09480	COG5520	Belongs to the glycosyl hydrolase 30 family
I33_RS09485	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_RS09490	COG2246	polysaccharide biosynthetic process
I33_RS09495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_RS09500	COG0586	Pfam SNARE associated Golgi protein
I33_RS09505	COG2404	hydrolase activity, acting on ester bonds
I33_RS09510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I33_RS09515	COG1024	Enoyl-CoA hydratase
I33_RS09520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I33_RS09525	COG0511	ligase activity, forming carbon-carbon bonds
I33_RS09530	COG0439	Biotin carboxylase
I33_RS09535	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS09540	COG1960	acyl-CoA dehydrogenase activity
I33_RS09560	COG1649	PFAM Uncharacterised BCR, COG1649
I33_RS09570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS09570	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I33_RS09575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS09580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS09585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS09590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS09595	COG2027	D-alanyl-D-alanine carboxypeptidase
I33_RS09600	COG2017	converts alpha-aldose to the beta-anomer
I33_RS09605	COG0534	Mate efflux family protein
I33_RS09620	COG0582	viral genome integration into host DNA
I33_RS09625	COG0166	Belongs to the GPI family
I33_RS09630	COG0405	Gamma-glutamyltransferase
I33_RS09635	COG0583	DNA-binding transcription factor activity
I33_RS09640	COG0604	alcohol dehydrogenase
I33_RS09645	COG0493	'glutamate synthase
I33_RS09650	COG0070	glutamate synthase
I33_RS09650	COG0069	glutamate synthase activity
I33_RS09650	COG0067	glutamate synthase
I33_RS09655	COG0583	DNA-binding transcription factor activity
I33_RS09660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I33_RS09665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_RS09675	COG0300	oxidoreductase activity
I33_RS09680	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I33_RS09690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I33_RS09695	COG2814	Major facilitator Superfamily
I33_RS09700	COG1070	Carbohydrate kinase
I33_RS09705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I33_RS09710	COG0243	molybdopterin cofactor binding
I33_RS09720	COG0673	inositol 2-dehydrogenase activity
I33_RS09725	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS09730	COG1609	Transcriptional regulator
I33_RS09750	COG0840	transmembrane signaling receptor activity
I33_RS09750	COG5278	phosphoserine phosphatase activity
I33_RS09755	COG2368	4-hydroxyphenylacetate
I33_RS09760	COG4305	rare lipoprotein A
I33_RS09765	COG3619	membrane
I33_RS09770	COG3866	Pectate lyase
I33_RS09775	COG2135	peptidase activity
I33_RS09785	COG2140	Oxalate decarboxylase
I33_RS09805	COG2720	vancomycin resistance protein
I33_RS09815	COG3655	Transcriptional regulator
I33_RS09820	COG3739	integral membrane protein
I33_RS09825	COG0583	DNA-binding transcription factor activity
I33_RS09830	COG0697	spore germination
I33_RS09840	COG0693	protein deglycase activity
I33_RS09845	COG2367	Beta-lactamase
I33_RS09860	COG3848	Pyruvate phosphate dikinase
I33_RS09860	COG0574	Belongs to the PEP-utilizing enzyme family
I33_RS09865	COG0726	polysaccharide deacetylase
I33_RS09875	COG2314	TM2 domain
I33_RS09895	COG2135	peptidase activity
I33_RS09905	COG2135	peptidase activity
I33_RS09910	COG0583	DNA-binding transcription factor activity
I33_RS09940	COG0457	Tetratricopeptide repeat
I33_RS09950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_RS09955	COG4282	regulation of fungal-type cell wall biogenesis
I33_RS09960	COG1231	oxidoreductase activity
I33_RS09965	COG5434	Belongs to the glycosyl hydrolase 28 family
I33_RS09970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_RS09975	COG0662	Cupin 2, conserved barrel domain protein
I33_RS09975	COG2207	Transcriptional regulator
I33_RS09980	COG0456	acetyltransferase
I33_RS09985	COG1309	transcriptional regulator
I33_RS09990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS09995	COG3708	Transcriptional regulator
I33_RS10000	COG2378	regulation of single-species biofilm formation
I33_RS10010	COG0640	Transcriptional regulator
I33_RS10015	COG0741	lytic transglycosylase activity
I33_RS10020	COG2322	membrane
I33_RS10035	COG1619	proteins homologs of microcin C7 resistance protein MccF
I33_RS10040	COG3239	Fatty acid desaturase
I33_RS10045	COG4585	Histidine kinase
I33_RS10050	COG2197	response regulator
I33_RS10055	COG3584	3D domain protein
I33_RS10055	COG1388	LysM domain
I33_RS10060	COG0514	ATP-dependent DNA helicase (RecQ)
I33_RS10070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I33_RS10075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_RS10090	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS10120	COG1657	PFAM Prenyltransferase squalene oxidase
I33_RS10125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I33_RS10130	COG0733	neurotransmitter:sodium symporter activity
I33_RS10135	COG0385	Bile acid
I33_RS10140	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_RS10145	COG0567	Dehydrogenase, E1 component
I33_RS10150	COG4548	von Willebrand factor, type A
I33_RS10155	COG0714	Associated with various cellular activities
I33_RS10160	COG2032	superoxide dismutase activity
I33_RS10165	COG1388	LysM domain
I33_RS10165	COG0791	NLP P60 protein
I33_RS10170	COG1819	glycosyl
I33_RS10175	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I33_RS10180	COG0534	Mate efflux family protein
I33_RS10185	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS10190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_RS10195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_RS10205	COG2962	Rard protein
I33_RS10220	COG2610	gluconate transmembrane transporter activity
I33_RS10225	COG1942	4-Oxalocrotonate Tautomerase
I33_RS10230	COG1733	regulation of RNA biosynthetic process
I33_RS10235	COG0778	Nitroreductase
I33_RS10240	COG0400	carboxylic ester hydrolase activity
I33_RS10245	COG0346	lactoylglutathione lyase activity
I33_RS10255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_RS10260	COG0793	Belongs to the peptidase S41A family
I33_RS10260	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS10265	COG2226	methyltransferase
I33_RS10275	COG1876	peptidase activity
I33_RS10280	COG0813	purine-nucleoside phosphorylase activity
I33_RS10290	COG0671	phosphoesterase, PA-phosphatase related
I33_RS10305	COG4479	Belongs to the UPF0346 family
I33_RS10315	COG1509	lysine 2,3-aminomutase activity
I33_RS10320	COG0456	acetyltransferase
I33_RS10325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_RS10330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I33_RS10335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I33_RS10340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_RS10350	COG0456	acetyltransferase
I33_RS10355	COG0463	Glycosyl transferase, family 2
I33_RS10370	COG4641	Protein conserved in bacteria
I33_RS10375	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
I33_RS10380	COG1086	Polysaccharide biosynthesis protein
I33_RS10385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I33_RS10390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I33_RS10395	COG1846	Transcriptional regulator
I33_RS10400	COG0534	Mate efflux family protein
I33_RS10410	COG4698	Protein conserved in bacteria
I33_RS10415	COG2755	lipolytic protein G-D-S-L family
I33_RS10420	COG1999	signal sequence binding
I33_RS10430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I33_RS10435	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I33_RS10440	COG1272	protein, Hemolysin III
I33_RS10445	COG0204	Acyl-transferase
I33_RS10450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I33_RS10455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I33_RS10465	COG2521	methyltransferase
I33_RS10465	COG2136	Putative SAM-dependent methyltransferase
I33_RS10475	COG0129	dihydroxy-acid dehydratase activity
I33_RS10480	COG1413	lyase activity
I33_RS10485	COG1418	mRNA catabolic process
I33_RS10490	COG0386	Belongs to the glutathione peroxidase family
I33_RS10495	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I33_RS10500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I33_RS10505	COG1278	Cold shock
I33_RS10525	COG0328	RNA-DNA hybrid ribonuclease activity
I33_RS10530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I33_RS10535	COG0328	RNA-DNA hybrid ribonuclease activity
I33_RS10545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_RS10555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I33_RS10560	COG1755	Isoprenylcysteine carboxyl methyltransferase
I33_RS10565	COG3424	synthase
I33_RS10570	COG2233	PERMEase
I33_RS10575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_RS10580	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I33_RS10590	COG0800	Aldolase
I33_RS10595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_RS10600	COG1609	Transcriptional regulator
I33_RS10605	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I33_RS10610	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS10615	COG1199	ATP-dependent helicase activity
I33_RS10625	COG0116	Belongs to the methyltransferase superfamily
I33_RS10635	COG4474	Belongs to the UPF0398 family
I33_RS10640	COG3359	exonuclease
I33_RS10645	COG1111	helicase
I33_RS10645	COG1205	dead DEAH box helicase
I33_RS10650	COG2190	(PTS) system
I33_RS10655	COG0071	Belongs to the small heat shock protein (HSP20) family
I33_RS10690	COG3331	DNA recombination
I33_RS10695	COG4499	WXG100 protein secretion system (Wss), protein YukC
I33_RS10695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_RS10705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I33_RS10710	COG3935	DnaD domain protein
I33_RS10715	COG0017	Asparaginyl-tRNA synthetase
I33_RS10720	COG0436	Aminotransferase
I33_RS10725	COG5353	protein conserved in bacteria
I33_RS10730	COG1199	ATP-dependent helicase activity
I33_RS10730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I33_RS10735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I33_RS10740	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I33_RS10745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I33_RS10750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I33_RS10750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I33_RS10755	COG0617	tRNA 3'-terminal CCA addition
I33_RS10760	COG0438	transferase activity, transferring glycosyl groups
I33_RS10765	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I33_RS10770	COG1803	Methylglyoxal synthase
I33_RS10775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I33_RS10780	COG1694	Mazg nucleotide pyrophosphohydrolase
I33_RS10785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS10800	COG2010	Cytochrome c
I33_RS10800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I33_RS10805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I33_RS10810	COG0723	plastoquinol--plastocyanin reductase activity
I33_RS10820	COG5582	Belongs to the UPF0302 family
I33_RS10825	COG0457	Tetratricopeptide repeat
I33_RS10830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I33_RS10835	COG0287	Prephenate dehydrogenase
I33_RS10845	COG0159	tryptophan synthase activity
I33_RS10850	COG0133	tryptophan synthase activity
I33_RS10855	COG0135	phosphoribosylanthranilate isomerase activity
I33_RS10865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I33_RS10870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I33_RS10875	COG4401	Chorismate mutase type I
I33_RS10880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I33_RS10885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I33_RS10890	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I33_RS10895	COG0105	UTP biosynthetic process
I33_RS10900	COG0142	geranyltranstransferase activity
I33_RS10905	COG2226	methyltransferase
I33_RS10910	COG0142	geranyltranstransferase activity
I33_RS10920	COG0302	gtp cyclohydrolase
I33_RS10925	COG0776	regulation of translation
I33_RS10930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I33_RS10945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I33_RS10950	COG1160	GTP binding
I33_RS10970	COG1304	FMN binding
I33_RS10975	COG0539	negative regulation of cytoplasmic translation
I33_RS10980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I33_RS10985	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I33_RS10990	COG2959	enzyme of heme biosynthesis
I33_RS10995	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS10995	COG3773	Cell wall hydrolase
I33_RS11000	COG2339	peptidase activity
I33_RS11005	COG0492	ferredoxin-NADP+ reductase activity
I33_RS11010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_RS11015	COG4862	establishment of competence for transformation
I33_RS11020	COG1408	metallophosphoesterase
I33_RS11030	COG1388	LysM domain
I33_RS11035	COG1266	CAAX protease self-immunity
I33_RS11040	COG0514	ATP-dependent DNA helicase (RecQ)
I33_RS11045	COG4955	Helix-turn-helix domain
I33_RS11050	COG1141	Ferredoxin
I33_RS11055	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I33_RS11060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I33_RS11065	COG0710	3-dehydroquinate dehydratase activity
I33_RS11075	COG1595	DNA-templated transcription, initiation
I33_RS11080	COG5002	protein histidine kinase activity
I33_RS11085	COG0745	RESPONSE REGULATOR receiver
I33_RS11090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I33_RS11095	COG1333	cytochrome c biogenesis protein
I33_RS11100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS11105	COG1187	pseudouridine synthase activity
I33_RS11110	COG0700	Nucleoside recognition
I33_RS11115	COG2715	membrane protein required for spore maturation
I33_RS11120	COG1686	Belongs to the peptidase S11 family
I33_RS11130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I33_RS11135	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I33_RS11140	COG1547	Domain of unknown function (DUF309)
I33_RS11145	COG0456	acetyltransferase
I33_RS11150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I33_RS11155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I33_RS11155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I33_RS11160	COG0307	riboflavin synthase, alpha
I33_RS11165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I33_RS11165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I33_RS11175	COG0681	Belongs to the peptidase S26 family
I33_RS11180	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I33_RS11200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I33_RS11230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I33_RS11235	COG4086	secreted protein
I33_RS11240	COG0019	diaminopimelate decarboxylase activity
I33_RS11245	COG0697	spore germination
I33_RS11260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I33_RS11280	COG1191	sigma factor activity
I33_RS11285	COG2172	sigma factor antagonist activity
I33_RS11290	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS11295	COG1686	Belongs to the peptidase S11 family
I33_RS11305	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I33_RS11310	COG4974	Belongs to the 'phage' integrase family
I33_RS11320	COG0735	belongs to the Fur family
I33_RS11325	COG1300	Membrane
I33_RS11335	COG0281	malic enzyme
I33_RS11340	COG1757	Na H antiporter
I33_RS11345	COG1027	Aspartate ammonia-lyase
I33_RS11350	COG0252	asparaginase activity
I33_RS11355	COG1396	sequence-specific DNA binding
I33_RS11360	COG1379	DNA repair
I33_RS11365	COG0494	nUDIX hydrolase
I33_RS11375	COG0667	Aldo Keto reductase
I33_RS11385	COG1073	alpha beta
I33_RS11395	COG4918	Iron-sulphur cluster biosynthesis
I33_RS11400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I33_RS11400	COG0456	acetyltransferase
I33_RS11405	COG2329	Antibiotic biosynthesis monooxygenase
I33_RS11410	COG0456	acetyltransferase
I33_RS11420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_RS11430	COG2211	Major facilitator Superfamily
I33_RS11435	COG0346	lactoylglutathione lyase activity
I33_RS11440	COG1072	(Pantothenic acid kinase))
I33_RS11445	COG3048	D-serine ammonia-lyase activity
I33_RS11450	COG0300	oxidoreductase activity
I33_RS11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS11460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_RS11465	COG4187	Peptidase family M20/M25/M40
I33_RS11470	COG1902	pentaerythritol trinitrate reductase activity
I33_RS11475	COG0596	Alpha beta hydrolase
I33_RS11485	COG1234	tRNA 3'-trailer cleavage
I33_RS11490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I33_RS11495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I33_RS11500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I33_RS11510	COG0706	membrane insertase activity
I33_RS11515	COG3361	conserved protein (COG2071)
I33_RS11520	COG2195	Cleaves the N-terminal amino acid of tripeptides
I33_RS11525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I33_RS11530	COG0346	lactoylglutathione lyase activity
I33_RS11535	COG1376	ErfK ybiS ycfS ynhG family protein
I33_RS11540	COG4129	membrane
I33_RS11545	COG1126	abc transporter atp-binding protein
I33_RS11550	COG0765	amino acid transport
I33_RS11555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_RS11565	COG1597	lipid kinase activity
I33_RS11570	COG2814	Major facilitator Superfamily
I33_RS11575	COG4978	Transcriptional regulator
I33_RS11575	COG0789	Transcriptional regulator
I33_RS11580	COG0508	dehydrogenase complex catalyzes the overall conversion of
I33_RS11585	COG0022	dehydrogenase e1 component
I33_RS11590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I33_RS11595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I33_RS11600	COG3426	butyrate kinase activity
I33_RS11605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_RS11610	COG0280	phosphate acetyltransferase
I33_RS11615	COG3290	protein histidine kinase activity
I33_RS11615	COG3829	transcription factor binding
I33_RS11625	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I33_RS11630	COG2079	MmgE PrpD family protein
I33_RS11635	COG0372	Belongs to the citrate synthase family
I33_RS11640	COG1960	acyl-CoA dehydrogenase activity
I33_RS11645	COG1250	3-hydroxyacyl-CoA dehydrogenase
I33_RS11650	COG0183	Belongs to the thiolase family
I33_RS11655	COG0584	glycerophosphoryl diester phosphodiesterase
I33_RS11660	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS11670	COG1902	pentaerythritol trinitrate reductase activity
I33_RS11675	COG0745	RESPONSE REGULATOR receiver
I33_RS11680	COG0750	zinc metalloprotease
I33_RS11685	COG0497	DNA recombination
I33_RS11690	COG1438	arginine binding
I33_RS11695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I33_RS11700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I33_RS11705	COG0142	geranyltranstransferase activity
I33_RS11710	COG1722	exodeoxyribonuclease VII activity
I33_RS11715	COG1570	exodeoxyribonuclease VII activity
I33_RS11720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I33_RS11725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I33_RS11730	COG1302	Protein conserved in bacteria
I33_RS11735	COG0439	Biotin carboxylase
I33_RS11740	COG0511	ligase activity, forming carbon-carbon bonds
I33_RS11780	COG3854	ATPases associated with a variety of cellular activities
I33_RS11790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I33_RS11795	COG0006	proline dipeptidase activity
I33_RS11800	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I33_RS11810	COG3872	metal-dependent enzyme
I33_RS11820	COG1752	Esterase of the alpha-beta hydrolase superfamily
I33_RS11825	COG1321	iron dependent repressor
I33_RS11830	COG0095	Lipoate-protein ligase
I33_RS11835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I33_RS11840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I33_RS11845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I33_RS11850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I33_RS11855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I33_RS11870	COG1396	sequence-specific DNA binding
I33_RS11880	COG0681	Belongs to the peptidase S26 family
I33_RS11905	COG4940	Competence protein ComGF
I33_RS11915	COG4970	Tfp pilus assembly protein FimT
I33_RS11920	COG4537	Required for transformation and DNA binding
I33_RS11925	COG1459	type II secretion system
I33_RS11930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I33_RS11935	COG0598	Magnesium transport protein CorA
I33_RS11940	COG1253	flavin adenine dinucleotide binding
I33_RS11945	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS11955	COG1393	Belongs to the ArsC family
I33_RS11965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS11975	COG0011	TIGRFAM Protein of
I33_RS11985	COG2866	Carboxypeptidase
I33_RS11990	COG1368	sulfuric ester hydrolase activity
I33_RS11995	COG1940	carbohydrate kinase activity
I33_RS12000	COG4483	Protein conserved in bacteria
I33_RS12005	COG0705	Rhomboid family
I33_RS12005	COG0457	Tetratricopeptide repeat
I33_RS12010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I33_RS12015	COG0438	transferase activity, transferring glycosyl groups
I33_RS12030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I33_RS12035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_RS12040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I33_RS12045	COG0581	inorganic phosphate transmembrane transporter activity
I33_RS12050	COG0573	inorganic phosphate transmembrane transporter activity
I33_RS12055	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I33_RS12060	COG0768	penicillin binding
I33_RS12065	COG0477	Major facilitator Superfamily
I33_RS12070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I33_RS12075	COG2839	Protein conserved in bacteria
I33_RS12080	COG5521	maltodextrose utilization protein MalA
I33_RS12085	COG1388	LysM domain
I33_RS12090	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I33_RS12095	COG4709	membrane
I33_RS12100	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I33_RS12105	COG0735	belongs to the Fur family
I33_RS12110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS12120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I33_RS12125	COG0513	Belongs to the DEAD box helicase family
I33_RS12135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I33_RS12140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I33_RS12145	COG2384	SAM-dependent methyltransferase
I33_RS12150	COG2010	Cytochrome c
I33_RS12155	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I33_RS12160	COG0358	DNA primase activity
I33_RS12165	COG1671	Belongs to the UPF0178 family
I33_RS12170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I33_RS12175	COG0517	IMP dehydrogenase activity
I33_RS12180	COG0751	glycine-tRNA ligase activity
I33_RS12185	COG0752	glycyl-tRNA synthetase alpha subunit
I33_RS12190	COG1381	Involved in DNA repair and RecF pathway recombination
I33_RS12195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I33_RS12200	COG0295	cytidine deaminase activity
I33_RS12205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I33_RS12210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I33_RS12215	COG1480	7TM receptor with intracellular HD hydrolase
I33_RS12220	COG1702	phosphate starvation-inducible protein PhoH
I33_RS12225	COG0561	phosphatase activity
I33_RS12240	COG4864	UPF0365 protein
I33_RS12245	COG1030	water channel activity
I33_RS12250	COG1610	YqeY-like protein
I33_RS12260	COG1283	sodium-dependent phosphate transmembrane transporter activity
I33_RS12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I33_RS12270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I33_RS12275	COG2264	protein methyltransferase activity
I33_RS12280	COG0484	heat shock protein binding
I33_RS12285	COG0443	Heat shock 70 kDa protein
I33_RS12290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I33_RS12295	COG1420	regulation of RNA biosynthetic process
I33_RS12300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I33_RS12305	COG0481	GTPase activity
I33_RS12315	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS12320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I33_RS12325	COG0268	Binds directly to 16S ribosomal RNA
I33_RS12330	COG1466	dna polymerase III delta subunit
I33_RS12340	COG2333	competence protein COMEC
I33_RS12340	COG0658	competence protein
I33_RS12345	COG2131	deaminase
I33_RS12350	COG1555	photosystem II stabilization
I33_RS12350	COG1596	polysaccharide export
I33_RS12355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I33_RS12360	COG2226	methyltransferase
I33_RS12365	COG0799	negative regulation of ribosome biogenesis
I33_RS12370	COG1713	HD superfamily hydrolase involved in NAD metabolism
I33_RS12375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I33_RS12380	COG1534	Rna-binding protein
I33_RS12385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I33_RS12390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I33_RS12395	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I33_RS12405	COG2755	lipolytic protein G-D-S-L family
I33_RS12410	COG5632	N-Acetylmuramoyl-L-alanine amidase
I33_RS12410	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS12415	COG0398	Pfam SNARE associated Golgi protein
I33_RS12420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I33_RS12430	COG3209	COG3209 Rhs family protein
I33_RS12440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I33_RS12450	COG1309	transcriptional regulator
I33_RS12465	COG4221	oxidoreductase activity
I33_RS12470	COG2814	Major facilitator Superfamily
I33_RS12475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_RS12480	COG0656	L-ascorbic acid biosynthetic process
I33_RS12495	COG0457	Tetratricopeptide repeat
I33_RS12510	COG5444	nuclease activity
I33_RS12535	COG4282	regulation of fungal-type cell wall biogenesis
I33_RS12565	COG4978	Transcriptional regulator
I33_RS12565	COG0789	Transcriptional regulator
I33_RS12570	COG2814	Major facilitator Superfamily
I33_RS12575	COG0456	acetyltransferase
I33_RS12580	COG1253	flavin adenine dinucleotide binding
I33_RS12590	COG2732	(Barnase) inhibitor
I33_RS12595	COG2124	cytochrome p450
I33_RS12600	COG1335	isochorismatase
I33_RS12610	COG2318	DinB family
I33_RS12620	COG2070	2-Nitropropane dioxygenase
I33_RS12630	COG0673	inositol 2-dehydrogenase activity
I33_RS12640	COG1733	regulation of RNA biosynthetic process
I33_RS12660	COG0789	Transcriptional regulator
I33_RS12660	COG4978	Transcriptional regulator
I33_RS12665	COG2315	Protein conserved in bacteria
I33_RS12675	COG3443	Belongs to the bacterial solute-binding protein 9 family
I33_RS12680	COG1595	DNA-templated transcription, initiation
I33_RS12685	COG0667	Aldo Keto reductase
I33_RS12690	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS12695	COG5566	PFAM Mor transcription activator
I33_RS12700	COG0596	Alpha beta hydrolase
I33_RS12705	COG4991	sh3 domain protein
I33_RS12710	COG4991	sh3 domain protein
I33_RS12715	COG0346	lactoylglutathione lyase activity
I33_RS12725	COG5577	PFAM Coat F domain
I33_RS12730	COG1063	alcohol dehydrogenase
I33_RS12740	COG5577	PFAM Coat F domain
I33_RS12745	COG0789	Transcriptional regulator
I33_RS12750	COG1064	alcohol dehydrogenase
I33_RS12755	COG0693	protein deglycase activity
I33_RS12760	COG1621	beta-fructofuranosidase activity
I33_RS12765	COG3716	PTS system mannose fructose sorbose family IID component
I33_RS12770	COG3715	PTS system
I33_RS12775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS12780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS12785	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I33_RS12785	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I33_RS12790	COG1113	amino acid transport
I33_RS12795	COG1280	lysine exporter protein (LysE YggA)
I33_RS12800	COG1378	Sugar-specific transcriptional regulator TrmB
I33_RS12805	COG1595	DNA-templated transcription, initiation
I33_RS12815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I33_RS12815	COG2755	lipolytic protein G-D-S-L family
I33_RS12825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_RS12825	COG2124	cytochrome p450
I33_RS12830	COG1309	transcriptional regulator
I33_RS12835	COG2226	methyltransferase
I33_RS12840	COG2116	formate transmembrane transporter activity
I33_RS12845	COG5609	conserved protein (DUF2294)
I33_RS12850	COG3383	formate dehydrogenase (NAD+) activity
I33_RS12855	COG2427	Protein of unknown function (DUF1641)
I33_RS12865	COG0626	cystathionine gamma-synthase activity
I33_RS12870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_RS12875	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I33_RS12880	COG2226	methyltransferase
I33_RS12895	COG0768	penicillin binding
I33_RS12900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I33_RS12905	COG0572	uridine kinase
I33_RS12910	COG0826	peptidase U32
I33_RS12915	COG0826	peptidase U32
I33_RS12920	COG4122	O-methyltransferase activity
I33_RS12925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I33_RS12930	COG3906	Belongs to the UPF0473 family
I33_RS12935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I33_RS12940	COG4472	Bacterial protein of unknown function (DUF965)
I33_RS12945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I33_RS12950	COG0628	permease
I33_RS12955	COG1126	abc transporter atp-binding protein
I33_RS12960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_RS12965	COG0765	amino acid transport
I33_RS12970	COG0765	amino acid transport
I33_RS12980	COG3881	PFAM PRC-barrel domain
I33_RS12985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I33_RS12990	COG0457	Tetratricopeptide repeat
I33_RS12995	COG0482	sulfurtransferase activity
I33_RS13000	COG1104	cysteine desulfurase activity
I33_RS13005	COG1959	2 iron, 2 sulfur cluster binding
I33_RS13010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I33_RS13015	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I33_RS13020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I33_RS13025	COG0124	histidyl-tRNA synthetase
I33_RS13030	COG3103	Sh3 type 3 domain protein
I33_RS13030	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS13030	COG4991	sh3 domain protein
I33_RS13035	COG1490	D-aminoacyl-tRNA deacylase activity
I33_RS13040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I33_RS13045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I33_RS13050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I33_RS13050	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I33_RS13055	COG5416	Lipopolysaccharide assembly protein A domain
I33_RS13060	COG0490	domain, Protein
I33_RS13065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I33_RS13065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I33_RS13075	COG2244	polysaccharide biosynthetic process
I33_RS13080	COG2323	membrane
I33_RS13090	COG1862	Preprotein translocase
I33_RS13095	COG0343	queuine tRNA-ribosyltransferase activity
I33_RS13100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I33_RS13110	COG2255	four-way junction helicase activity
I33_RS13115	COG0632	four-way junction helicase activity
I33_RS13125	COG2814	Major facilitator Superfamily
I33_RS13130	COG0673	inositol 2-dehydrogenase activity
I33_RS13135	COG2112	serine threonine protein kinase
I33_RS13150	COG1115	amino acid carrier protein
I33_RS13155	COG0217	transcriptional regulatory protein
I33_RS13165	COG1388	LysM domain
I33_RS13170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I33_RS13175	COG0157	Belongs to the NadC ModD family
I33_RS13180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I33_RS13185	COG1104	cysteine desulfurase activity
I33_RS13190	COG1827	regulation of RNA biosynthetic process
I33_RS13195	COG0077	Prephenate dehydratase
I33_RS13200	COG4492	Belongs to the UPF0735 family
I33_RS13205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I33_RS13210	COG3290	protein histidine kinase activity
I33_RS13215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I33_RS13220	COG2868	ribosomal protein
I33_RS13225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I33_RS13230	COG1994	Peptidase M50
I33_RS13235	COG0739	heme binding
I33_RS13240	COG2894	cell division
I33_RS13245	COG0850	regulation of cytokinetic process
I33_RS13250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I33_RS13260	COG1077	Cell shape determining protein MreB Mrl
I33_RS13265	COG2003	Belongs to the UPF0758 family
I33_RS13270	COG0424	maF-like protein
I33_RS13280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I33_RS13285	COG0285	dihydrofolate synthase activity
I33_RS13290	COG0525	valine-tRNA ligase activity
I33_RS13300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_RS13305	COG1388	LysM domain
I33_RS13310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I33_RS13315	COG0113	porphobilinogen synthase activity
I33_RS13320	COG1587	Uroporphyrinogen-III synthase
I33_RS13325	COG0181	hydroxymethylbilane synthase activity
I33_RS13330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I33_RS13335	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I33_RS13345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I33_RS13350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I33_RS13355	COG1067	ATP-dependent peptidase activity
I33_RS13355	COG0470	DNA polymerase III
I33_RS13360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I33_RS13365	COG0544	peptidyl-prolyl cis-trans isomerase activity
I33_RS13370	COG1477	protein flavinylation
I33_RS13370	COG0457	Tetratricopeptide repeat
I33_RS13375	COG0066	3-isopropylmalate dehydratase activity
I33_RS13380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I33_RS13385	COG0473	3-isopropylmalate dehydrogenase activity
I33_RS13390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I33_RS13395	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I33_RS13400	COG0440	acetolactate synthase activity
I33_RS13405	COG0028	Belongs to the TPP enzyme family
I33_RS13415	COG0454	-acetyltransferase
I33_RS13425	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I33_RS13435	COG0622	Phosphoesterase
I33_RS13440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I33_RS13445	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I33_RS13450	COG5401	PFAM Sporulation and spore germination
I33_RS13455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I33_RS13460	COG1846	Transcriptional regulator
I33_RS13465	COG2197	response regulator
I33_RS13470	COG0824	Thioesterase
I33_RS13475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I33_RS13480	COG1053	succinate dehydrogenase
I33_RS13485	COG2009	succinate dehydrogenase
I33_RS13490	COG1719	4-vinyl reductase, 4VR
I33_RS13495	COG0527	aspartate kinase activity
I33_RS13500	COG0322	excinuclease ABC activity
I33_RS13505	COG3118	belongs to the thioredoxin family
I33_RS13510	COG3534	alpha-L-arabinofuranosidase
I33_RS13515	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I33_RS13520	COG2086	electron transfer activity
I33_RS13525	COG1024	Enoyl-CoA hydratase
I33_RS13530	COG1309	transcriptional regulator
I33_RS13535	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS13540	COG3766	membrane
I33_RS13545	COG1193	negative regulation of DNA recombination
I33_RS13550	COG1796	DNA polymerase
I33_RS13550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I33_RS13555	COG1286	toxin biosynthetic process
I33_RS13560	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I33_RS13565	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I33_RS13570	COG0072	phenylalanine-tRNA ligase activity
I33_RS13570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_RS13575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I33_RS13580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I33_RS13590	COG3835	regulator
I33_RS13595	COG0277	FAD linked oxidase domain protein
I33_RS13600	COG0247	lactate metabolic process
I33_RS13605	COG0346	lactoylglutathione lyase activity
I33_RS13610	COG1966	Carbon starvation protein
I33_RS13615	COG3534	alpha-L-arabinofuranosidase
I33_RS13620	COG0395	ABC-type sugar transport system, permease component
I33_RS13625	COG1175	transmembrane transport
I33_RS13630	COG1653	transport
I33_RS13635	COG0371	Dehydrogenase
I33_RS13640	COG0647	UMP catabolic process
I33_RS13645	COG0235	Class ii aldolase
I33_RS13650	COG1069	ribulokinase activity
I33_RS13655	COG2160	L-arabinose isomerase activity
I33_RS13660	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_RS13665	COG1363	Peptidase, m42
I33_RS13675	COG3326	Membrane
I33_RS13680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I33_RS13685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I33_RS13690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I33_RS13700	COG1346	cytolysis
I33_RS13705	COG1380	Effector of murein hydrolase LrgA
I33_RS13710	COG3279	Response regulator of the LytR AlgR family
I33_RS13715	COG3275	phosphorelay sensor kinase activity
I33_RS13720	COG1011	Hydrolase
I33_RS13725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I33_RS13735	COG0398	Pfam SNARE associated Golgi protein
I33_RS13740	COG1484	DNA-dependent DNA replication
I33_RS13745	COG3611	Membrane attachment protein
I33_RS13750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I33_RS13755	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I33_RS13760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I33_RS13765	COG1733	regulation of RNA biosynthetic process
I33_RS13770	COG2814	Major facilitator Superfamily
I33_RS13775	COG0656	L-ascorbic acid biosynthetic process
I33_RS13780	COG0237	dephospho-CoA kinase activity
I33_RS13785	COG1971	Probably functions as a manganese efflux pump
I33_RS13790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I33_RS13795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_RS13795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I33_RS13800	COG5002	protein histidine kinase activity
I33_RS13805	COG0745	RESPONSE REGULATOR receiver
I33_RS13810	COG0039	L-malate dehydrogenase activity
I33_RS13815	COG0538	isocitrate dehydrogenase activity
I33_RS13820	COG0372	Belongs to the citrate synthase family
I33_RS13825	COG2707	UPF0756 membrane protein
I33_RS13830	COG0628	permease
I33_RS13835	COG3030	protein affecting phage T7 exclusion by the F plasmid
I33_RS13840	COG0469	pyruvate kinase activity
I33_RS13845	COG0205	6-phosphofructokinase activity
I33_RS13850	COG0825	malonyl-CoA metabolic process
I33_RS13855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I33_RS13860	COG0281	malic enzyme
I33_RS13865	COG0587	DNA-directed DNA polymerase activity
I33_RS13885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I33_RS13895	COG4109	DRTGG domain
I33_RS13900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I33_RS13905	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS13910	COG0165	Argininosuccinate lyase
I33_RS13915	COG0137	argininosuccinate synthase activity
I33_RS13920	COG0521	Mo-molybdopterin cofactor biosynthetic process
I33_RS13925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I33_RS13930	COG0827	DNA restriction-modification system
I33_RS13935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I33_RS13940	COG3874	Sporulation protein YtfJ
I33_RS13950	COG1714	RDD family
I33_RS13955	COG0616	signal peptide processing
I33_RS13960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I33_RS13965	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I33_RS13970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I33_RS13980	COG0301	tRNA thio-modification
I33_RS13985	COG1104	cysteine desulfurase activity
I33_RS13990	COG1114	Component of the transport system for branched-chain amino acids
I33_RS13995	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I33_RS14000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I33_RS14005	COG1309	transcriptional regulator
I33_RS14010	COG1956	GAF domain-containing protein
I33_RS14015	COG2203	Gaf domain
I33_RS14015	COG2199	diguanylate cyclase activity
I33_RS14020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I33_RS14025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I33_RS14030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I33_RS14035	COG0454	-acetyltransferase
I33_RS14040	COG0517	IMP dehydrogenase activity
I33_RS14045	COG0123	including yeast histone deacetylase and acetoin utilization protein
I33_RS14050	COG1360	Flagellar Motor Protein
I33_RS14055	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I33_RS14060	COG1609	Transcriptional regulator
I33_RS14065	COG1605	Chorismate mutase
I33_RS14065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I33_RS14070	COG3118	belongs to the thioredoxin family
I33_RS14075	COG4980	gas vesicle protein
I33_RS14080	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I33_RS14085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I33_RS14095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I33_RS14100	COG4848	Belongs to the UPF0354 family
I33_RS14105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS14115	COG1363	Peptidase, m42
I33_RS14120	COG5584	Small secreted protein
I33_RS14125	COG0281	malic enzyme
I33_RS14130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS14135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I33_RS14145	COG0510	thiamine kinase activity
I33_RS14150	COG1523	belongs to the glycosyl hydrolase 13 family
I33_RS14155	COG1597	lipid kinase activity
I33_RS14165	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I33_RS14170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I33_RS14175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_RS14180	COG2252	PERMEase
I33_RS14185	COG4473	ABC transporter
I33_RS14190	COG1131	(ABC) transporter
I33_RS14195	COG1349	DNA-binding transcription factor activity
I33_RS14200	COG1187	pseudouridine synthase activity
I33_RS14205	COG2244	polysaccharide biosynthetic process
I33_RS14210	COG2081	HI0933 family
I33_RS14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I33_RS14225	COG5578	integral membrane protein
I33_RS14230	COG0673	inositol 2-dehydrogenase activity
I33_RS14235	COG1653	transport
I33_RS14240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I33_RS14245	COG4209	transmembrane transport
I33_RS14250	COG2207	Transcriptional regulator
I33_RS14255	COG1653	transport
I33_RS14260	COG0395	ABC-type sugar transport system, permease component
I33_RS14265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_RS14270	COG2124	cytochrome p450
I33_RS14275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I33_RS14285	COG0156	8-amino-7-oxononanoate synthase activity
I33_RS14290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I33_RS14300	COG1073	alpha beta
I33_RS14305	COG1609	Transcriptional regulator
I33_RS14310	COG1653	transport
I33_RS14315	COG1175	transmembrane transport
I33_RS14320	COG0395	ABC-type sugar transport system, permease component
I33_RS14325	COG1486	melibiose metabolic process
I33_RS14330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I33_RS14335	COG0495	leucyl-tRNA aminoacylation
I33_RS14345	COG1366	Belongs to the anti-sigma-factor antagonist family
I33_RS14345	COG2202	Pas domain
I33_RS14350	COG2814	Major facilitator Superfamily
I33_RS14355	COG2433	Pfam Transposase IS66
I33_RS14360	COG0577	efflux transmembrane transporter activity
I33_RS14365	COG1136	(ABC) transporter
I33_RS14370	COG2205	protein histidine kinase activity
I33_RS14375	COG0745	RESPONSE REGULATOR receiver
I33_RS14380	COG0577	efflux transmembrane transporter activity
I33_RS14385	COG1136	(ABC) transporter
I33_RS14400	COG1131	(ABC) transporter
I33_RS14405	COG1725	Transcriptional regulator
I33_RS14415	COG1242	4 iron, 4 sulfur cluster binding
I33_RS14420	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I33_RS14430	COG2267	carboxylic ester hydrolase activity
I33_RS14435	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I33_RS14440	COG1113	amino acid transport
I33_RS14445	COG0367	asparagine synthase
I33_RS14450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I33_RS14455	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I33_RS14465	COG1506	peptidase
I33_RS14470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I33_RS14475	COG1116	anion transmembrane transporter activity
I33_RS14480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I33_RS14485	COG0494	nUDIX hydrolase
I33_RS14490	COG4824	toxin secretion phage lysis holin
I33_RS14495	COG0783	Belongs to the Dps family
I33_RS14510	COG1854	S-ribosylhomocysteine lyase activity
I33_RS14515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I33_RS14520	COG0288	reversible hydration of carbon dioxide
I33_RS14525	COG0254	rRNA binding
I33_RS14530	COG1271	oxidase subunit
I33_RS14535	COG1294	oxidase, subunit
I33_RS14540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_RS14545	COG1321	iron dependent repressor
I33_RS14545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I33_RS14550	COG1121	(ABC) transporter
I33_RS14555	COG0803	Belongs to the bacterial solute-binding protein 9 family
I33_RS14560	COG4948	Mandelate Racemase Muconate Lactonizing
I33_RS14565	COG0318	PFAM AMP-dependent synthetase and ligase
I33_RS14570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I33_RS14575	COG0596	Alpha beta hydrolase
I33_RS14580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I33_RS14585	COG1169	isochorismate synthase
I33_RS14590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I33_RS14595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_RS14600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_RS14605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I33_RS14610	COG0438	transferase activity, transferring glycosyl groups
I33_RS14620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_RS14625	COG0438	transferase activity, transferring glycosyl groups
I33_RS14630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_RS14635	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I33_RS14640	COG0058	SHG alpha-glucan phosphorylase activity
I33_RS14645	COG0297	glycogen (starch) synthase activity
I33_RS14650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I33_RS14655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I33_RS14660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I33_RS14785	COG3859	Proton-coupled thiamine transporter YuaJ
I33_RS14790	COG1247	-acetyltransferase
I33_RS14795	COG2268	Band 7 protein
I33_RS14800	COG1585	Membrane protein implicated in regulation of membrane protease activity
I33_RS14805	COG2318	DinB family
I33_RS14815	COG1454	alcohol dehydrogenase
I33_RS14820	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS14825	COG1510	regulation of RNA biosynthetic process
I33_RS14835	COG0569	domain protein
I33_RS14840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I33_RS14845	COG4682	membrane
I33_RS14850	COG1705	Flagellar rod assembly protein muramidase FlgJ
I33_RS14855	COG0477	Major facilitator Superfamily
I33_RS14860	COG5553	Cysteine dioxygenase type I
I33_RS14870	COG1968	undecaprenyl-diphosphatase activity
I33_RS14875	COG0628	permease
I33_RS14880	COG0673	inositol 2-dehydrogenase activity
I33_RS14885	COG4806	L-rhamnose isomerase
I33_RS14890	COG3254	rhamnose metabolic process
I33_RS14895	COG1070	Carbohydrate kinase
I33_RS14900	COG1349	DNA-binding transcription factor activity
I33_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS14905	COG3347	Dehydrogenase
I33_RS14915	COG0840	transmembrane signaling receptor activity
I33_RS14920	COG0840	transmembrane signaling receptor activity
I33_RS14925	COG0840	transmembrane signaling receptor activity
I33_RS14930	COG0840	transmembrane signaling receptor activity
I33_RS14945	COG0432	Pfam Uncharacterised protein family UPF0047
I33_RS14950	COG0366	Alpha amylase catalytic
I33_RS14955	COG1253	flavin adenine dinucleotide binding
I33_RS14960	COG2738	Putative neutral zinc metallopeptidase
I33_RS14975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I33_RS14990	COG0166	Belongs to the GPI family
I33_RS14995	COG1979	alcohol dehydrogenase
I33_RS15000	COG1979	alcohol dehydrogenase
I33_RS15005	COG2155	Conserved Protein
I33_RS15010	COG1098	S1 RNA binding domain
I33_RS15015	COG0436	Aminotransferase
I33_RS15020	COG1522	sequence-specific DNA binding
I33_RS15025	COG2267	carboxylic ester hydrolase activity
I33_RS15035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I33_RS15040	COG2205	protein histidine kinase activity
I33_RS15050	COG5018	Exonuclease
I33_RS15060	COG2814	Major facilitator Superfamily
I33_RS15065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_RS15070	COG3011	Protein conserved in bacteria
I33_RS15080	COG3290	protein histidine kinase activity
I33_RS15085	COG4565	transcriptional regulatory protein
I33_RS15090	COG1744	ABC transporter substrate-binding protein PnrA-like
I33_RS15095	COG3845	ABC transporter
I33_RS15100	COG4603	Belongs to the binding-protein-dependent transport system permease family
I33_RS15105	COG1079	Belongs to the binding-protein-dependent transport system permease family
I33_RS15110	COG3493	citrate carrier protein
I33_RS15120	COG2111	Na H antiporter
I33_RS15120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I33_RS15125	COG2111	Na H antiporter
I33_RS15130	COG1006	Multisubunit Na H antiporter MnhC subunit
I33_RS15135	COG0651	ATP synthesis coupled electron transport
I33_RS15140	COG1863	multisubunit Na H antiporter MnhE subunit
I33_RS15145	COG2212	antiporter activity
I33_RS15150	COG1320	monovalent cation:proton antiporter activity
I33_RS15155	COG2050	protein possibly involved in aromatic compounds catabolism
I33_RS15160	COG2197	response regulator
I33_RS15165	COG4585	Histidine kinase
I33_RS15175	COG0142	geranyltranstransferase activity
I33_RS15190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I33_RS15195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I33_RS15200	COG1335	isochorismatase
I33_RS15205	COG5506	Protein of unknown function (DUF1694)
I33_RS15220	COG0628	permease
I33_RS15235	COG1418	mRNA catabolic process
I33_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS15250	COG1511	domain protein
I33_RS15255	COG1674	ftsk spoiiie
I33_RS15255	COG0433	COG0433 Predicted ATPase
I33_RS15260	COG4499	WXG100 protein secretion system (Wss), protein YukC
I33_RS15265	COG5417	Belongs to the EsaB family
I33_RS15270	COG4842	Belongs to the WXG100 family
I33_RS15275	COG2508	Transcriptional regulator
I33_RS15275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I33_RS15280	COG0686	Belongs to the AlaDH PNT family
I33_RS15285	COG5634	Uncharacterized conserved protein (DUF2278)
I33_RS15290	COG3251	PFAM MbtH domain protein
I33_RS15295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS15300	COG3433	isochorismatase activity
I33_RS15300	COG1535	isochorismatase
I33_RS15305	COG1021	2,3-dihydroxybenzoate-AMP ligase
I33_RS15310	COG1169	isochorismate synthase
I33_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS15320	COG2819	hydrolase of the alpha beta superfamily
I33_RS15325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I33_RS15330	COG1268	BioY protein
I33_RS15335	COG2056	Na+-H+ antiporter family
I33_RS15340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I33_RS15345	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I33_RS15350	COG3584	3D domain protein
I33_RS15360	COG1252	NADH dehydrogenase
I33_RS15365	COG0492	ferredoxin-NADP+ reductase activity
I33_RS15370	COG0516	GMP reductase activity
I33_RS15385	COG1131	(ABC) transporter
I33_RS15405	COG2808	Putative FMN-binding domain
I33_RS15410	COG0456	acetyltransferase
I33_RS15415	COG0316	Belongs to the HesB IscA family
I33_RS15420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I33_RS15425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_RS15430	COG4844	belongs to the
I33_RS15435	COG1252	NADH dehydrogenase
I33_RS15440	COG4837	Protein of unknown function (DUF1462)
I33_RS15445	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I33_RS15450	COG1506	peptidase
I33_RS15450	COG0823	Involved in the tonB-independent uptake of proteins
I33_RS15450	COG4946	Tricorn protease homolog
I33_RS15455	COG0083	homoserine kinase activity
I33_RS15460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I33_RS15465	COG0460	homoserine dehydrogenase
I33_RS15470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I33_RS15475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I33_RS15480	COG0647	UMP catabolic process
I33_RS15485	COG2445	Protein of unknown function DUF86
I33_RS15490	COG4470	Protein conserved in bacteria
I33_RS15500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I33_RS15505	COG0739	heme binding
I33_RS15515	COG3377	Domain of unknown function (DUF1805)
I33_RS15520	COG0737	Belongs to the 5'-nucleotidase family
I33_RS15525	COG0730	response to heat
I33_RS15530	COG1801	Protein of unknown function DUF72
I33_RS15540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I33_RS15545	COG2508	Transcriptional regulator
I33_RS15550	COG2233	PERMEase
I33_RS15555	COG2233	PERMEase
I33_RS15560	COG3648	Uricase
I33_RS15560	COG3195	allantoin biosynthetic process
I33_RS15565	COG2351	hydroxyisourate hydrolase activity
I33_RS15580	COG2080	2 iron, 2 sulfur cluster binding
I33_RS15585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I33_RS15590	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I33_RS15595	COG2068	MobA-Related Protein
I33_RS15600	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I33_RS15605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I33_RS15610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I33_RS15615	COG2356	endonuclease I
I33_RS15620	COG3842	ATPase activity
I33_RS15625	COG2188	Transcriptional regulator
I33_RS15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_RS15635	COG0395	ABC-type sugar transport system, permease component
I33_RS15640	COG1175	transmembrane transport
I33_RS15645	COG1653	transport
I33_RS15650	COG2222	sugar isomerase
I33_RS15655	COG0322	excinuclease ABC activity
I33_RS15660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I33_RS15675	COG0346	lactoylglutathione lyase activity
I33_RS15680	COG0719	Fe-S assembly protein
I33_RS15685	COG0822	iron-sulfur transferase activity
I33_RS15690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I33_RS15695	COG0719	Fe-S assembly protein
I33_RS15700	COG0396	ATPase activity
I33_RS15705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I33_RS15710	COG1464	Belongs to the NlpA lipoprotein family
I33_RS15715	COG2011	ABC-type metal ion transport system permease component
I33_RS15720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I33_RS15730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I33_RS15735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I33_RS15745	COG0509	glycine decarboxylation via glycine cleavage system
I33_RS15750	COG1393	Belongs to the ArsC family
I33_RS15755	COG1960	acyl-CoA dehydrogenase activity
I33_RS15760	COG0183	Belongs to the thiolase family
I33_RS15765	COG1250	3-hydroxyacyl-CoA dehydrogenase
I33_RS15765	COG1024	Enoyl-CoA hydratase
I33_RS15770	COG0506	proline dehydrogenase activity
I33_RS15780	COG5577	PFAM Coat F domain
I33_RS15785	COG1846	Transcriptional regulator
I33_RS15790	COG0477	Major facilitator Superfamily
I33_RS15795	COG1942	4-Oxalocrotonate Tautomerase
I33_RS15800	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS15805	COG0583	DNA-binding transcription factor activity
I33_RS15815	COG1120	ATPase activity
I33_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS15835	COG0783	Belongs to the Dps family
I33_RS15840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_RS15845	COG0745	RESPONSE REGULATOR receiver
I33_RS15850	COG2205	protein histidine kinase activity
I33_RS15850	COG2770	Histidine kinase
I33_RS15855	COG1309	transcriptional regulator
I33_RS15860	COG0114	fumarate hydratase activity
I33_RS15870	COG0697	spore germination
I33_RS15875	COG0814	amino acid
I33_RS15885	COG2197	response regulator
I33_RS15890	COG4585	Histidine kinase
I33_RS15895	COG4758	membrane
I33_RS15900	COG3595	metallopeptidase activity
I33_RS15905	COG1842	Phage shock protein A
I33_RS15910	COG4758	membrane
I33_RS15915	COG2814	Major facilitator Superfamily
I33_RS15920	COG2096	Adenosyltransferase
I33_RS15925	COG1120	ATPase activity
I33_RS15930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS15935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS15940	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS15945	COG3386	PFAM SMP-30 Gluconolaconase
I33_RS15950	COG2205	protein histidine kinase activity
I33_RS15955	COG0745	RESPONSE REGULATOR receiver
I33_RS15965	COG1191	sigma factor activity
I33_RS15970	COG2140	Oxalate decarboxylase
I33_RS15980	COG0577	efflux transmembrane transporter activity
I33_RS15985	COG1136	(ABC) transporter
I33_RS15990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I33_RS15995	COG1120	ATPase activity
I33_RS16000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS16005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I33_RS16010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS16020	COG0531	amino acid
I33_RS16030	COG1988	membrane-bound metal-dependent
I33_RS16035	COG1368	sulfuric ester hydrolase activity
I33_RS16040	COG1910	domain protein
I33_RS16045	COG0725	ABC transporter, periplasmic molybdate-binding protein
I33_RS16050	COG4149	molybdate abc transporter
I33_RS16055	COG0656	L-ascorbic acid biosynthetic process
I33_RS16065	COG0025	NhaP-type Na H and K H
I33_RS16070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I33_RS16075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I33_RS16080	COG3973	AAA domain
I33_RS16090	COG2860	membrane
I33_RS16095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I33_RS16100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I33_RS16105	COG2217	Heavy metal translocating P-type atpase
I33_RS16110	COG2217	Heavy metal translocating P-type atpase
I33_RS16115	COG2608	mercury ion transmembrane transporter activity
I33_RS16120	COG1937	Protein conserved in bacteria
I33_RS16125	COG0673	inositol 2-dehydrogenase activity
I33_RS16130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I33_RS16135	COG1289	transmembrane transporter activity
I33_RS16145	COG2076	Multidrug Resistance protein
I33_RS16150	COG1309	transcriptional regulator
I33_RS16155	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS16170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I33_RS16175	COG0557	exoribonuclease II activity
I33_RS16180	COG1647	Serine aminopeptidase, S33
I33_RS16185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I33_RS16190	COG0596	Alpha beta hydrolase
I33_RS16195	COG1476	TRANSCRIPTIONal
I33_RS16200	COG1396	sequence-specific DNA binding
I33_RS16205	COG1396	sequence-specific DNA binding
I33_RS16210	COG1733	regulation of RNA biosynthetic process
I33_RS16215	COG0840	transmembrane signaling receptor activity
I33_RS16220	COG1174	glycine betaine transport
I33_RS16225	COG1732	Glycine betaine
I33_RS16230	COG1174	glycine betaine transport
I33_RS16235	COG0517	IMP dehydrogenase activity
I33_RS16235	COG1125	glycine betaine transport
I33_RS16240	COG1510	regulation of RNA biosynthetic process
I33_RS16245	COG1174	glycine betaine transport
I33_RS16250	COG1732	Glycine betaine
I33_RS16255	COG1174	glycine betaine transport
I33_RS16260	COG1125	glycine betaine transport
I33_RS16260	COG0517	IMP dehydrogenase activity
I33_RS16265	COG1510	regulation of RNA biosynthetic process
I33_RS16270	COG2095	MarC family integral membrane protein
I33_RS16280	COG3064	Membrane
I33_RS16285	COG4640	response to antibiotic
I33_RS16290	COG0456	acetyltransferase
I33_RS16295	COG0148	phosphopyruvate hydratase activity
I33_RS16300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I33_RS16305	COG0149	triose-phosphate isomerase activity
I33_RS16310	COG0126	phosphoglycerate kinase activity
I33_RS16315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I33_RS16320	COG2390	Transcriptional regulator
I33_RS16325	COG2814	Major facilitator Superfamily
I33_RS16330	COG1609	Transcriptional regulator
I33_RS16335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_RS16340	COG0583	DNA-binding transcription factor activity
I33_RS16345	COG0697	spore germination
I33_RS16350	COG1113	amino acid transport
I33_RS16355	COG3858	chitin binding
I33_RS16360	COG1556	Lactate utilization protein
I33_RS16365	COG1139	Iron-sulfur cluster binding protein
I33_RS16370	COG0247	lactate metabolic process
I33_RS16375	COG2197	response regulator
I33_RS16380	COG4585	Histidine kinase
I33_RS16385	COG0842	Transport permease protein
I33_RS16390	COG1131	(ABC) transporter
I33_RS16395	COG0596	Alpha beta hydrolase
I33_RS16400	COG2208	phosphoserine phosphatase activity
I33_RS16405	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I33_RS16410	COG1874	Beta-galactosidase
I33_RS16415	COG3833	ABC-type maltose transport systems, permease component
I33_RS16420	COG1175	transmembrane transport
I33_RS16425	COG2182	Extracellular solute-binding protein
I33_RS16430	COG1609	Transcriptional regulator
I33_RS16435	COG2186	Transcriptional regulator
I33_RS16440	COG1620	l-lactate permease
I33_RS16445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I33_RS16455	COG5039	Polysaccharide pyruvyl transferase
I33_RS16460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_RS16465	COG0110	maltose O-acetyltransferase activity
I33_RS16470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I33_RS16475	COG2244	polysaccharide biosynthetic process
I33_RS16480	COG1216	Glycosyl transferase, family 2
I33_RS16485	COG5039	Polysaccharide pyruvyl transferase
I33_RS16490	COG1216	Glycosyl transferase, family 2
I33_RS16500	COG0438	transferase activity, transferring glycosyl groups
I33_RS16505	COG1215	transferase activity, transferring glycosyl groups
I33_RS16510	COG0438	transferase activity, transferring glycosyl groups
I33_RS16515	COG1086	Polysaccharide biosynthesis protein
I33_RS16520	COG0489	protein tyrosine kinase activity
I33_RS16525	COG3944	biosynthesis protein
I33_RS16530	COG1396	sequence-specific DNA binding
I33_RS16535	COG2272	Belongs to the type-B carboxylesterase lipase family
I33_RS16540	COG3479	Phenolic acid decarboxylase
I33_RS16550	COG1794	racemase activity, acting on amino acids and derivatives
I33_RS16555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I33_RS16560	COG1621	beta-fructofuranosidase activity
I33_RS16565	COG1621	beta-fructofuranosidase activity
I33_RS16570	COG0531	amino acid
I33_RS16575	COG1309	transcriptional regulator
I33_RS16580	COG2076	Multidrug Resistance protein
I33_RS16585	COG2076	Multidrug Resistance protein
I33_RS16600	COG0740	serine-type endopeptidase activity
I33_RS16605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I33_RS16610	COG0366	Alpha amylase catalytic
I33_RS16615	COG1554	hydrolase, family 65, central catalytic
I33_RS16620	COG5521	maltodextrose utilization protein MalA
I33_RS16625	COG3833	ABC-type maltose transport systems, permease component
I33_RS16630	COG1175	transmembrane transport
I33_RS16635	COG2182	Extracellular solute-binding protein
I33_RS16640	COG0366	Alpha amylase catalytic
I33_RS16645	COG1609	Transcriptional regulator
I33_RS16650	COG1611	Belongs to the LOG family
I33_RS16655	COG1694	Mazg nucleotide pyrophosphohydrolase
I33_RS16660	COG0659	secondary active sulfate transmembrane transporter activity
I33_RS16665	COG0288	reversible hydration of carbon dioxide
I33_RS16670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I33_RS16675	COG0577	efflux transmembrane transporter activity
I33_RS16680	COG1136	(ABC) transporter
I33_RS16685	COG5002	protein histidine kinase activity
I33_RS16690	COG0745	RESPONSE REGULATOR receiver
I33_RS16700	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I33_RS16705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS16710	COG1481	regulation of sporulation
I33_RS16715	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I33_RS16720	COG1660	Displays ATPase and GTPase activities
I33_RS16725	COG1051	belongs to the nudix hydrolase family
I33_RS16730	COG0492	ferredoxin-NADP+ reductase activity
I33_RS16765	COG0457	Tetratricopeptide repeat
I33_RS16770	COG1132	(ABC) transporter
I33_RS16810	COG0140	phosphoribosyl-ATP diphosphatase activity
I33_RS16810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I33_RS16815	COG0107	imidazoleglycerol-phosphate synthase activity
I33_RS16820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I33_RS16825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I33_RS16830	COG0131	Imidazoleglycerol-phosphate dehydratase
I33_RS16835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I33_RS16840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I33_RS16845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I33_RS16850	COG4990	cell redox homeostasis
I33_RS16855	COG5297	Belongs to the glycosyl hydrolase family 6
I33_RS16860	COG0110	maltose O-acetyltransferase activity
I33_RS16865	COG0546	phosphoglycolate phosphatase activity
I33_RS16870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I33_RS16875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I33_RS16880	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I33_RS16885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I33_RS16890	COG0363	glucosamine-6-phosphate deaminase activity
I33_RS16895	COG2188	Transcriptional regulator
I33_RS16900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I33_RS16905	COG1950	PFAM Membrane protein of
I33_RS16910	COG1983	PspC domain protein
I33_RS16915	COG3595	metallopeptidase activity
I33_RS16930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_RS16935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I33_RS16940	COG0556	nucleotide-excision repair
I33_RS16945	COG4897	Protein conserved in bacteria
I33_RS16950	COG3848	Pyruvate phosphate dikinase
I33_RS16950	COG0574	Belongs to the PEP-utilizing enzyme family
I33_RS16955	COG1309	transcriptional regulator
I33_RS16960	COG2814	Major facilitator Superfamily
I33_RS16965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_RS16975	COG3409	Peptidoglycan-binding domain 1 protein
I33_RS16975	COG0793	Belongs to the peptidase S41A family
I33_RS16980	COG2177	Part of the ABC transporter FtsEX involved in
I33_RS16985	COG2884	Cell division ATP-binding protein ftsE
I33_RS16990	COG2010	Cytochrome c
I33_RS16995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS17000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I33_RS17005	COG0653	protein targeting
I33_RS17010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I33_RS17025	COG1516	flagellar protein fliS
I33_RS17030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I33_RS17035	COG1334	flagellar protein FlaG
I33_RS17040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_RS17045	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I33_RS17050	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I33_RS17060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I33_RS17065	COG1256	bacterial-type flagellum assembly
I33_RS17065	COG4786	Flagellar basal body rod
I33_RS17070	COG3418	PFAM FlgN family protein
I33_RS17075	COG2747	anti-sigma28 factor FlgM
I33_RS17085	COG1040	competence protein
I33_RS17095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I33_RS17100	COG1307	EDD domain protein, DegV family
I33_RS17105	COG2197	response regulator
I33_RS17110	COG4585	Histidine kinase
I33_RS17115	COG1739	Uncharacterized protein family UPF0029
I33_RS17120	COG1316	TRANSCRIPTIONal
I33_RS17125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I33_RS17130	COG0438	transferase activity, transferring glycosyl groups
I33_RS17135	COG1215	transferase activity, transferring glycosyl groups
I33_RS17140	COG3206	protein involved in exopolysaccharide biosynthesis
I33_RS17145	COG3307	-O-antigen
I33_RS17150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_RS17155	COG0438	transferase activity, transferring glycosyl groups
I33_RS17155	COG0297	glycogen (starch) synthase activity
I33_RS17160	COG2244	polysaccharide biosynthetic process
I33_RS17170	COG2247	cell wall binding repeat
I33_RS17170	COG0860	N-Acetylmuramoyl-L-alanine amidase
I33_RS17175	COG2385	sporulation resulting in formation of a cellular spore
I33_RS17175	COG2247	cell wall binding repeat
I33_RS17185	COG1316	TRANSCRIPTIONal
I33_RS17190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I33_RS17195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I33_RS17200	COG1134	teichoic acid transport
I33_RS17205	COG1682	transport, permease protein
I33_RS17210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_RS17215	COG0438	transferase activity, transferring glycosyl groups
I33_RS17220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I33_RS17225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I33_RS17230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_RS17240	COG4193	domain, Protein
I33_RS17245	COG1482	cell wall glycoprotein biosynthetic process
I33_RS17250	COG0697	spore germination
I33_RS17255	COG0814	amino acid
I33_RS17265	COG2814	Major facilitator Superfamily
I33_RS17270	COG1316	TRANSCRIPTIONal
I33_RS17275	COG0561	phosphatase activity
I33_RS17280	COG0791	NLP P60 protein
I33_RS17285	COG2843	Capsule synthesis protein
I33_RS17295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I33_RS17300	COG1609	Transcriptional regulator
I33_RS17305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_RS17310	COG1869	D-ribose catabolic process
I33_RS17315	COG1129	ABC transporter
I33_RS17320	COG1172	Belongs to the binding-protein-dependent transport system permease family
I33_RS17325	COG1879	ABC-type sugar transport system periplasmic component
I33_RS17330	COG3103	Sh3 type 3 domain protein
I33_RS17340	COG2249	NAD(P)H dehydrogenase (quinone) activity
I33_RS17345	COG3527	Alpha-acetolactate decarboxylase
I33_RS17350	COG0028	Belongs to the TPP enzyme family
I33_RS17355	COG0583	DNA-binding transcription factor activity
I33_RS17360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I33_RS17375	COG5337	Spore coat protein CotH
I33_RS17385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I33_RS17395	COG0405	Gamma-glutamyltransferase
I33_RS17400	COG1522	sequence-specific DNA binding
I33_RS17405	COG2059	Chromate
I33_RS17410	COG2059	Chromate
I33_RS17415	COG1515	deoxyribonuclease V activity
I33_RS17440	COG5444	nuclease activity
I33_RS17455	COG3878	Protein conserved in bacteria
I33_RS17460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I33_RS17465	COG4464	protein tyrosine phosphatase activity
I33_RS17470	COG0489	protein tyrosine kinase activity
I33_RS17475	COG3944	biosynthesis protein
I33_RS17480	COG4715	Zinc finger, swim domain protein
I33_RS17485	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I33_RS17490	COG0561	phosphatase activity
I33_RS17495	COG1349	DNA-binding transcription factor activity
I33_RS17500	COG0629	single-stranded DNA binding
I33_RS17515	COG3764	Sortase (surface protein transpeptidase)
I33_RS17525	COG3279	Response regulator of the LytR AlgR family
I33_RS17530	COG2972	Histidine kinase
I33_RS17530	COG0745	RESPONSE REGULATOR receiver
I33_RS17535	COG1970	mechanosensitive ion channel activity
I33_RS17540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I33_RS17545	COG0457	Tetratricopeptide repeat
I33_RS17550	COG4786	Flagellar basal body rod
I33_RS17555	COG4786	Flagellar basal body rod
I33_RS17560	COG1077	Cell shape determining protein MreB Mrl
I33_RS17565	COG1609	Transcriptional regulator
I33_RS17570	COG1846	Transcriptional regulator
I33_RS17575	COG2814	Major facilitator Superfamily
I33_RS17585	COG3420	alginic acid biosynthetic process
I33_RS17590	COG1953	Uracil, thiamine, allantoin
I33_RS17595	COG0477	Major facilitator Superfamily
I33_RS17600	COG1335	isochorismatase
I33_RS17610	COG0004	ammonium transporteR
I33_RS17615	COG0347	Belongs to the P(II) protein family
I33_RS17620	COG0671	phosphoesterase, PA-phosphatase related
I33_RS17630	COG0739	heme binding
I33_RS17635	COG1247	-acetyltransferase
I33_RS17650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_RS17655	COG0789	Transcriptional regulator
I33_RS17665	COG2910	NAD(P)H-binding
I33_RS17670	COG1959	2 iron, 2 sulfur cluster binding
I33_RS17675	COG0804	urea catabolic process
I33_RS17680	COG0832	Belongs to the urease beta subunit family
I33_RS17685	COG0831	urea catabolic process
I33_RS17700	COG3237	CsbD-like
I33_RS17705	COG1994	Peptidase M50
I33_RS17710	COG0457	Tetratricopeptide repeat
I33_RS17715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I33_RS17720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I33_RS17725	COG2304	oxidoreductase activity
I33_RS17735	COG2304	oxidoreductase activity
I33_RS17740	COG2385	sporulation resulting in formation of a cellular spore
I33_RS17745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I33_RS17755	COG4836	Membrane
I33_RS17765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I33_RS17770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I33_RS17775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I33_RS17780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I33_RS17785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I33_RS17790	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I33_RS17800	COG0356	it plays a direct role in the translocation of protons across the membrane
I33_RS17810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I33_RS17815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I33_RS17820	COG4475	Protein of unknown function (DUF436)
I33_RS17825	COG0698	ribose 5-phosphate isomerase
I33_RS17830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I33_RS17835	COG1971	Probably functions as a manganese efflux pump
I33_RS17840	COG0009	L-threonylcarbamoyladenylate synthase
I33_RS17845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I33_RS17865	COG2890	protein-(glutamine-N5) methyltransferase activity
I33_RS17870	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I33_RS17875	COG0346	lactoylglutathione lyase activity
I33_RS17880	COG0789	Transcriptional regulator
I33_RS17885	COG0679	Auxin Efflux Carrier
I33_RS17890	COG0281	malic enzyme
I33_RS17895	COG1435	thymidine kinase activity
I33_RS17905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I33_RS17910	COG1494	fructose-1,6-bisphosphatase
I33_RS17915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I33_RS17920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I33_RS17925	COG0191	fructose-bisphosphate aldolase activity
I33_RS17930	COG2204	response regulator
I33_RS17935	COG4821	SIS domain
I33_RS17940	COG0504	CTP synthase activity
I33_RS17945	COG3343	RNA polymerase activity
I33_RS17950	COG1960	acyl-CoA dehydrogenase activity
I33_RS17955	COG2181	nitrate reductase activity
I33_RS17955	COG0247	lactate metabolic process
I33_RS17960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_RS17965	COG4294	response to UV
I33_RS17975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I33_RS17980	COG1132	(ABC) transporter
I33_RS17985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I33_RS17990	COG2181	nitrate reductase activity
I33_RS17995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I33_RS18000	COG1140	nitrate reductase beta subunit
I33_RS18005	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I33_RS18010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I33_RS18020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I33_RS18025	COG2223	nitrite transmembrane transporter activity
I33_RS18030	COG0018	arginyl-trna synthetase
I33_RS18035	COG4506	Protein conserved in bacteria
I33_RS18045	COG0535	radical SAM domain protein
I33_RS18055	COG1131	(ABC) transporter
I33_RS18060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I33_RS18065	COG0612	Peptidase, M16
I33_RS18070	COG0612	Peptidase, M16
I33_RS18080	COG3391	amine dehydrogenase activity
I33_RS18085	COG3391	amine dehydrogenase activity
I33_RS18095	COG0457	Tetratricopeptide repeat
I33_RS18110	COG0010	Belongs to the arginase family
I33_RS18115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I33_RS18120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I33_RS18135	COG1994	Peptidase M50
I33_RS18140	COG1942	4-Oxalocrotonate Tautomerase
I33_RS18145	COG1846	Transcriptional regulator
I33_RS18150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I33_RS18155	COG0477	Major facilitator Superfamily
I33_RS18160	COG1959	2 iron, 2 sulfur cluster binding
I33_RS18165	COG3465	dGTPase activity
I33_RS18170	COG1078	dGTPase activity
I33_RS18175	COG4844	belongs to the
I33_RS18185	COG0697	spore germination
I33_RS18190	COG0095	Lipoate-protein ligase
I33_RS18195	COG0583	DNA-binding transcription factor activity
I33_RS18200	COG0280	phosphate acetyltransferase
I33_RS18205	COG3253	May function as heme-dependent peroxidase
I33_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS18215	COG0436	Aminotransferase
I33_RS18220	COG2814	Major facilitator Superfamily
I33_RS18225	COG0151	Belongs to the GarS family
I33_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS18235	COG1917	Cupin 2, conserved barrel domain protein
I33_RS18240	COG0077	Prephenate dehydratase
I33_RS18245	COG2814	Major facilitator Superfamily
I33_RS18250	COG0833	amino acid
I33_RS18255	COG4187	Peptidase family M20/M25/M40
I33_RS18260	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS18265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I33_RS18275	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I33_RS18280	COG1091	dTDP-4-dehydrorhamnose reductase activity
I33_RS18285	COG1088	dTDP-glucose 4,6-dehydratase activity
I33_RS18290	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I33_RS18295	COG3980	spore coat polysaccharide biosynthesis protein
I33_RS18300	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I33_RS18305	COG2089	acid synthase
I33_RS18310	COG0456	acetyltransferase
I33_RS18315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I33_RS18320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I33_RS18325	COG0463	Glycosyl transferase, family 2
I33_RS18340	COG2363	Small membrane protein
I33_RS18345	COG2233	PERMEase
I33_RS18355	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS18360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I33_RS18365	COG1216	Glycosyl transferase, family 2
I33_RS18370	COG0351	phosphomethylpyrimidine kinase
I33_RS18380	COG1621	beta-fructofuranosidase activity
I33_RS18385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS18385	COG1263	PTS System
I33_RS18390	COG2116	formate transmembrane transporter activity
I33_RS18405	COG1404	Belongs to the peptidase S8 family
I33_RS18410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_RS18415	COG0778	Nitroreductase
I33_RS18420	COG0772	Belongs to the SEDS family
I33_RS18430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I33_RS18435	COG1845	cytochrome c oxidase, subunit III
I33_RS18440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I33_RS18445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I33_RS18450	COG2261	transglycosylase associated protein
I33_RS18455	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I33_RS18460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I33_RS18465	COG2246	polysaccharide biosynthetic process
I33_RS18470	COG1309	transcriptional regulator
I33_RS18480	COG3162	membrane
I33_RS18485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I33_RS18490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I33_RS18495	COG2837	iron assimilation
I33_RS18500	COG2822	iron ion transport
I33_RS18505	COG0672	)-iron permease
I33_RS18510	COG0352	thiamine-phosphate diphosphorylase activity
I33_RS18515	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I33_RS18520	COG0583	DNA-binding transcription factor activity
I33_RS18525	COG1380	Effector of murein hydrolase LrgA
I33_RS18530	COG1346	cytolysis
I33_RS18535	COG2814	Major facilitator Superfamily
I33_RS18540	COG4895	conserved protein (DUF2196)
I33_RS18545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I33_RS18550	COG0346	lactoylglutathione lyase activity
I33_RS18560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_RS18565	COG1404	Belongs to the peptidase S8 family
I33_RS18570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS18570	COG1263	PTS System
I33_RS18575	COG3711	transcriptional antiterminator
I33_RS18580	COG1442	glycosyl transferase family 8
I33_RS18585	COG5522	Integral membrane protein (intg_mem_TP0381)
I33_RS18590	COG1846	Transcriptional regulator
I33_RS18595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I33_RS18600	COG2234	aminopeptidase activity
I33_RS18605	COG2357	RelA SpoT domain protein
I33_RS18610	COG1575	Belongs to the MenA family. Type 1 subfamily
I33_RS18620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I33_RS18625	COG1696	Membrane protein involved in D-alanine export
I33_RS18630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I33_RS18635	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I33_RS18640	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I33_RS18645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I33_RS18650	COG1486	melibiose metabolic process
I33_RS18655	COG1447	Phosphotransferase system cellobiose-specific component IIA
I33_RS18660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_RS18665	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I33_RS18670	COG3711	transcriptional antiterminator
I33_RS18670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I33_RS18675	COG2094	Belongs to the DNA glycosylase MPG family
I33_RS18680	COG0753	catalase activity
I33_RS18685	COG2814	Major facilitator Superfamily
I33_RS18690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I33_RS18695	COG1131	(ABC) transporter
I33_RS18715	COG1595	DNA-templated transcription, initiation
I33_RS18720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I33_RS18725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I33_RS18730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I33_RS18735	COG4988	ABC transporter
I33_RS18740	COG1294	oxidase, subunit
I33_RS18745	COG1271	oxidase subunit
I33_RS18750	COG3493	citrate carrier protein
I33_RS18755	COG0501	Belongs to the peptidase M48B family
I33_RS18765	COG0726	polysaccharide deacetylase
I33_RS18770	COG3842	ATPase activity
I33_RS18775	COG2508	Transcriptional regulator
I33_RS18780	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS18785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I33_RS18795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I33_RS18800	COG1881	PFAM PEBP family protein
I33_RS18805	COG0583	DNA-binding transcription factor activity
I33_RS18815	COG4585	Histidine kinase
I33_RS18820	COG2197	response regulator
I33_RS18825	COG2195	Cleaves the N-terminal amino acid of tripeptides
I33_RS18830	COG4894	glucomannan catabolic process
I33_RS18835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_RS18840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I33_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS18850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I33_RS18855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I33_RS18860	COG2610	gluconate transmembrane transporter activity
I33_RS18865	COG0500	methyltransferase
I33_RS18870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_RS18885	COG0753	catalase activity
I33_RS18885	COG0693	protein deglycase activity
I33_RS18890	COG2851	Citrate transporter
I33_RS18895	COG2273	Hydrolase Family 16
I33_RS18900	COG3711	transcriptional antiterminator
I33_RS18910	COG2270	Major facilitator Superfamily
I33_RS18915	COG0513	Belongs to the DEAD box helicase family
I33_RS18920	COG2755	lipolytic protein G-D-S-L family
I33_RS18920	COG3401	FG-GAP repeat protein
I33_RS18950	COG0697	spore germination
I33_RS18955	COG0589	response to stress
I33_RS18960	COG2723	6-phospho-beta-galactosidase activity
I33_RS18965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS18965	COG2190	(PTS) system
I33_RS18965	COG1263	PTS System
I33_RS19015	COG5444	nuclease activity
I33_RS19040	COG0494	nUDIX hydrolase
I33_RS19045	COG3507	Belongs to the glycosyl hydrolase 43 family
I33_RS19055	COG2986	histidine ammonia-lyase
I33_RS19060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I33_RS19065	COG1228	amidohydrolase
I33_RS19070	COG0010	Belongs to the arginase family
I33_RS19075	COG0833	amino acid
I33_RS19080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I33_RS19085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I33_RS19090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I33_RS19095	COG2390	Transcriptional regulator
I33_RS19105	COG3192	ethanolamine utilization protein
I33_RS19110	COG2079	MmgE PrpD family protein
I33_RS19115	COG1473	amidohydrolase
I33_RS19120	COG1126	abc transporter atp-binding protein
I33_RS19125	COG0765	amino acid transport
I33_RS19130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I33_RS19135	COG0456	acetyltransferase
I33_RS19140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I33_RS19150	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I33_RS19155	COG0561	phosphatase activity
I33_RS19185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I33_RS19190	COG5294	Protein conserved in bacteria
I33_RS19195	COG0577	efflux transmembrane transporter activity
I33_RS19200	COG1136	(ABC) transporter
I33_RS19205	COG2205	protein histidine kinase activity
I33_RS19210	COG0745	RESPONSE REGULATOR receiver
I33_RS19215	COG0191	fructose-bisphosphate aldolase activity
I33_RS19220	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS19225	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS19230	COG0673	inositol 2-dehydrogenase activity
I33_RS19235	COG2814	Major facilitator Superfamily
I33_RS19240	COG1082	Xylose isomerase domain protein TIM barrel
I33_RS19245	COG3962	Belongs to the TPP enzyme family
I33_RS19250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I33_RS19260	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS19265	COG1349	DNA-binding transcription factor activity
I33_RS19270	COG0667	Aldo Keto reductase
I33_RS19295	COG2814	Major facilitator Superfamily
I33_RS19300	COG0326	Molecular chaperone. Has ATPase activity
I33_RS19310	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS19315	COG1309	transcriptional regulator
I33_RS19320	COG1012	belongs to the aldehyde dehydrogenase family
I33_RS19330	COG0789	Transcriptional regulator
I33_RS19335	COG1714	RDD family
I33_RS19340	COG2311	Membrane
I33_RS19345	COG1917	Cupin 2, conserved barrel domain protein
I33_RS19350	COG1309	transcriptional regulator
I33_RS19355	COG1028	Short-chain dehydrogenase reductase Sdr
I33_RS19360	COG1846	Transcriptional regulator
I33_RS19365	COG1380	Effector of murein hydrolase LrgA
I33_RS19370	COG1346	cytolysis
I33_RS19375	COG5039	Polysaccharide pyruvyl transferase
I33_RS19380	COG1929	Belongs to the glycerate kinase type-1 family
I33_RS19385	COG1802	Transcriptional regulator
I33_RS19390	COG1070	Carbohydrate kinase
I33_RS19395	COG2610	gluconate transmembrane transporter activity
I33_RS19400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I33_RS19405	COG0450	alkyl hydroperoxide reductase
I33_RS19410	COG3634	alkyl hydroperoxide reductase activity
I33_RS19415	COG2723	6-phospho-beta-galactosidase activity
I33_RS19420	COG1263	PTS System
I33_RS19420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I33_RS19420	COG2190	(PTS) system
I33_RS19425	COG2188	Transcriptional regulator
I33_RS19440	COG1131	(ABC) transporter
I33_RS19445	COG1994	Peptidase M50
I33_RS19450	COG0535	radical SAM domain protein
I33_RS19460	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I33_RS19490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I33_RS19500	COG1063	alcohol dehydrogenase
I33_RS19520	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I33_RS19525	COG0456	acetyltransferase
I33_RS19530	COG0457	Tetratricopeptide repeat
I33_RS19540	COG0010	Belongs to the arginase family
I33_RS19545	COG0833	amino acid
I33_RS19550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I33_RS19555	COG3829	transcription factor binding
I33_RS19560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I33_RS19565	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I33_RS19570	COG4853	Protein conserved in bacteria
I33_RS19575	COG4863	YycH protein
I33_RS19580	COG5002	protein histidine kinase activity
I33_RS19585	COG0745	RESPONSE REGULATOR receiver
I33_RS19615	COG0346	lactoylglutathione lyase activity
I33_RS19620	COG0305	Participates in initiation and elongation during chromosome replication
I33_RS19635	COG2807	transmembrane transport
I33_RS19640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I33_RS19645	COG0359	binds to the 23S rRNA
I33_RS19650	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I33_RS19655	COG4241	membrane
I33_RS19665	COG5577	PFAM Coat F domain
I33_RS19670	COG1733	regulation of RNA biosynthetic process
I33_RS19675	COG1227	inorganic diphosphatase activity
I33_RS19690	COG2271	Major facilitator Superfamily
I33_RS19695	COG0789	Transcriptional regulator
I33_RS19695	COG4978	Transcriptional regulator
I33_RS19705	COG4319	ketosteroid isomerase
I33_RS19710	COG1357	PFAM Pentapeptide repeats (8 copies)
I33_RS19715	COG2814	Major facilitator Superfamily
I33_RS19720	COG0583	DNA-binding transcription factor activity
I33_RS19725	COG2153	protein acetylation
I33_RS19735	COG0583	DNA-binding transcription factor activity
I33_RS19755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I33_RS19760	COG1846	Transcriptional regulator
I33_RS19765	COG2153	protein acetylation
I33_RS19770	COG2364	Membrane
I33_RS19780	COG1331	Highly conserved protein containing a thioredoxin domain
I33_RS19785	COG1266	CAAX protease self-immunity
I33_RS19790	COG0477	Major facilitator Superfamily
I33_RS19790	COG2814	Major facilitator Superfamily
I33_RS19795	COG0110	maltose O-acetyltransferase activity
I33_RS19800	COG0346	lactoylglutathione lyase activity
I33_RS19805	COG1609	Transcriptional regulator
I33_RS19810	COG0708	Exodeoxyribonuclease III
I33_RS19815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I33_RS19820	COG0629	single-stranded DNA binding
I33_RS19825	COG0360	Binds together with S18 to 16S ribosomal RNA
I33_RS19830	COG0012	GTP binding
I33_RS19835	COG0243	molybdopterin cofactor binding
I33_RS19840	COG4481	Protein conserved in bacteria
I33_RS19845	COG3949	Membrane
I33_RS19855	COG1475	DNA binding
I33_RS19860	COG1192	Involved in chromosome partitioning
I33_RS19870	COG1475	DNA binding
I33_RS19875	COG0357	Ribosomal RNA small subunit methyltransferase G
I33_RS19880	COG0445	tRNA wobble uridine modification
I33_RS19885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I33_RS19890	COG1847	R3H domain protein
I33_RS19895	COG0706	membrane insertase activity
I33_RS19900	COG0594	ribonuclease P activity
I33_RS19930	COG5444	nuclease activity