locus-tag	class	description
HCN55_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HCN55_RS00010	COG0592	DNA-directed DNA polymerase activity
HCN55_RS00015	COG2501	S4 domain
HCN55_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCN55_RS00030	COG0187	DNA topoisomerase II activity
HCN55_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCN55_RS00070	COG0517	IMP dehydrogenase activity
HCN55_RS00070	COG0516	GMP reductase activity
HCN55_RS00075	COG1686	Belongs to the peptidase S11 family
HCN55_RS00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HCN55_RS00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HCN55_RS00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HCN55_RS00145	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HCN55_RS00150	COG3853	Toxic anion resistance protein (TelA)
HCN55_RS00155	COG1982	Orn Lys Arg decarboxylase major
HCN55_RS00160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCN55_RS00165	COG3870	Protein conserved in bacteria
HCN55_RS00170	COG1728	Protein conserved in bacteria
HCN55_RS00175	COG0470	DNA polymerase III
HCN55_RS00180	COG1774	PSP1 C-terminal conserved region
HCN55_RS00185	COG4467	Involved in initiation control of chromosome replication
HCN55_RS00190	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCN55_RS00195	COG2827	Endonuclease containing a URI domain
HCN55_RS00200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCN55_RS00205	COG2002	toxin-antitoxin pair type II binding
HCN55_RS00210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN55_RS00210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN55_RS00215	COG0084	hydrolase, TatD family'
HCN55_RS00220	COG3584	3D domain protein
HCN55_RS00220	COG3583	domain protein
HCN55_RS00225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCN55_RS00230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HCN55_RS00240	COG4466	Protein conserved in bacteria
HCN55_RS00250	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HCN55_RS00255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN55_RS00260	COG0251	oxidation-reduction process
HCN55_RS00265	COG2088	sporulation resulting in formation of a cellular spore
HCN55_RS00270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HCN55_RS00275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HCN55_RS00280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HCN55_RS00285	COG0193	aminoacyl-tRNA hydrolase activity
HCN55_RS00295	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCN55_RS00300	COG2002	toxin-antitoxin pair type II binding
HCN55_RS00305	COG2244	polysaccharide biosynthetic process
HCN55_RS00310	COG3956	TIGRFAM MazG family protein
HCN55_RS00315	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCN55_RS00330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HCN55_RS00335	COG1098	S1 RNA binding domain
HCN55_RS00350	COG2208	phosphoserine phosphatase activity
HCN55_RS00355	COG2304	oxidoreductase activity
HCN55_RS00360	COG0515	serine threonine protein kinase
HCN55_RS00365	COG0037	tRNA processing
HCN55_RS00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN55_RS00380	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HCN55_RS00385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HCN55_RS00390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN55_RS00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN55_RS00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN55_RS00405	COG0512	Glutamine amidotransferase of anthranilate synthase
HCN55_RS00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN55_RS00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCN55_RS00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCN55_RS00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCN55_RS00430	COG1396	sequence-specific DNA binding
HCN55_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCN55_RS00440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HCN55_RS00520	COG4463	regulation of RNA biosynthetic process
HCN55_RS00525	COG3880	PFAM UvrB UvrC protein
HCN55_RS00530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HCN55_RS00535	COG0542	response to heat
HCN55_RS00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCN55_RS00545	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HCN55_RS00550	COG4956	integral membrane protein (PIN domain superfamily)
HCN55_RS00555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HCN55_RS00560	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HCN55_RS00565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HCN55_RS00570	COG1045	serine acetyltransferase
HCN55_RS00575	COG0215	cysteine-tRNA ligase activity
HCN55_RS00580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HCN55_RS00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN55_RS00590	COG3688	RNA-binding protein containing a PIN domain
HCN55_RS00595	COG1595	DNA-templated transcription, initiation
HCN55_RS00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCN55_RS00610	COG0250	Participates in transcription elongation, termination and antitermination
HCN55_RS00620	COG0081	regulation of translation
HCN55_RS00625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HCN55_RS00635	COG2813	Specifically methylates the guanine in position
HCN55_RS00640	COG0085	RNA polymerase activity
HCN55_RS00645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HCN55_RS00650	COG1358	cellular component organization or biogenesis
HCN55_RS00655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HCN55_RS00660	COG0049	tRNA binding
HCN55_RS00665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HCN55_RS00670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HCN55_RS00675	COG0596	Alpha beta hydrolase
HCN55_RS00685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HCN55_RS00690	COG0088	Forms part of the polypeptide exit tunnel
HCN55_RS00700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HCN55_RS00715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HCN55_RS00720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HCN55_RS00730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HCN55_RS00735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HCN55_RS00745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HCN55_RS00755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HCN55_RS00760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HCN55_RS00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HCN55_RS00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HCN55_RS00780	COG0200	Binds to the 23S rRNA
HCN55_RS00785	COG0201	protein transport
HCN55_RS00790	COG0563	adenylate kinase activity
HCN55_RS00795	COG0024	Methionine aminopeptidase
HCN55_RS00810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCN55_RS00815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HCN55_RS00820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HCN55_RS00825	COG0202	RNA polymerase activity
HCN55_RS00830	COG0203	ribosomal protein L17
HCN55_RS00835	COG1122	ATPase activity
HCN55_RS00840	COG1122	ATPase activity
HCN55_RS00845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCN55_RS00850	COG0101	tRNA pseudouridine synthase activity
HCN55_RS00855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HCN55_RS00860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HCN55_RS00865	COG2226	methyltransferase
HCN55_RS00875	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS00880	COG0489	protein tyrosine kinase activity
HCN55_RS00890	COG2194	sulfuric ester hydrolase activity
HCN55_RS00895	COG0726	polysaccharide deacetylase
HCN55_RS00975	COG0659	secondary active sulfate transmembrane transporter activity
HCN55_RS00980	COG0385	Bile acid
HCN55_RS00985	COG2819	hydrolase of the alpha beta superfamily
HCN55_RS00990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS01000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS01005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS01005	COG2207	Transcriptional regulator
HCN55_RS01010	COG3876	Protein conserved in bacteria
HCN55_RS01015	COG1472	Belongs to the glycosyl hydrolase 3 family
HCN55_RS01020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCN55_RS01025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS01025	COG1263	PTS System
HCN55_RS01030	COG1737	Transcriptional regulator
HCN55_RS01035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HCN55_RS01040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS01045	COG1683	Conserved Protein
HCN55_RS01075	COG1595	DNA-templated transcription, initiation
HCN55_RS01080	COG5662	AntiSigma factor
HCN55_RS01085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCN55_RS01090	COG4856	YbbR-like protein
HCN55_RS01095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN55_RS01100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HCN55_RS01110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCN55_RS01115	COG2169	Transcriptional regulator
HCN55_RS01120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCN55_RS01125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCN55_RS01130	COG3002	Belongs to the UPF0753 family
HCN55_RS01135	COG0288	reversible hydration of carbon dioxide
HCN55_RS01145	COG5609	conserved protein (DUF2294)
HCN55_RS01150	COG0640	Transcriptional regulator
HCN55_RS01155	COG2814	Major facilitator Superfamily
HCN55_RS01170	COG0535	radical SAM domain protein
HCN55_RS01175	COG1266	CAAX protease self-immunity
HCN55_RS01180	COG1131	(ABC) transporter
HCN55_RS01190	COG1413	lyase activity
HCN55_RS01195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS01200	COG0596	Alpha beta hydrolase
HCN55_RS01205	COG0745	RESPONSE REGULATOR receiver
HCN55_RS01210	COG0642	Histidine kinase
HCN55_RS01220	COG0515	serine threonine protein kinase
HCN55_RS01235	COG1113	amino acid transport
HCN55_RS01250	COG2602	Beta-lactamase
HCN55_RS01255	COG2124	cytochrome p450
HCN55_RS01265	COG0531	amino acid
HCN55_RS01270	COG0584	glycerophosphoryl diester phosphodiesterase
HCN55_RS01275	COG2271	Major facilitator Superfamily
HCN55_RS01285	COG0456	acetyltransferase
HCN55_RS01285	COG1846	Transcriptional regulator
HCN55_RS01290	COG2271	Major facilitator Superfamily
HCN55_RS01300	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS01305	COG0697	spore germination
HCN55_RS01310	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS01310	COG2207	Transcriptional regulator
HCN55_RS01315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HCN55_RS01320	COG3591	Belongs to the peptidase S1B family
HCN55_RS01330	COG0596	Alpha beta hydrolase
HCN55_RS01335	COG1183	phosphatidylcholine synthase activity
HCN55_RS01340	COG0586	Pfam SNARE associated Golgi protein
HCN55_RS01345	COG0688	phosphatidylethanolamine metabolic process
HCN55_RS01355	COG2312	Erythromycin esterase
HCN55_RS01360	COG2207	Transcriptional regulator
HCN55_RS01370	COG1301	dicarboxylic acid transport
HCN55_RS01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS01375	COG2190	(PTS) system
HCN55_RS01375	COG1263	PTS System
HCN55_RS01380	COG0363	glucosamine-6-phosphate deaminase activity
HCN55_RS01385	COG2188	Transcriptional regulator
HCN55_RS01395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN55_RS01400	COG0833	amino acid
HCN55_RS01405	COG2040	homocysteine
HCN55_RS01415	COG1115	amino acid carrier protein
HCN55_RS01420	COG2066	Belongs to the glutaminase family
HCN55_RS01425	COG4191	Histidine kinase
HCN55_RS01430	COG0784	Response regulator, receiver
HCN55_RS01435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN55_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS01445	COG2271	Major facilitator Superfamily
HCN55_RS01450	COG4948	Mandelate Racemase Muconate Lactonizing
HCN55_RS01455	COG2186	Transcriptional regulator
HCN55_RS01460	COG2721	sulfolactate sulfo-lyase activity
HCN55_RS01465	COG3173	Aminoglycoside phosphotransferase
HCN55_RS01475	COG0697	spore germination
HCN55_RS01480	COG0745	RESPONSE REGULATOR receiver
HCN55_RS01485	COG2205	protein histidine kinase activity
HCN55_RS01490	COG1131	(ABC) transporter
HCN55_RS01510	COG3773	Cell wall hydrolase
HCN55_RS01515	COG2304	oxidoreductase activity
HCN55_RS01525	COG3540	Alkaline phosphatase
HCN55_RS01530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN55_RS01535	COG0805	protein transport
HCN55_RS01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HCN55_RS01545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCN55_RS01550	COG0477	Major facilitator Superfamily
HCN55_RS01555	COG1309	transcriptional regulator
HCN55_RS01560	COG0252	asparaginase activity
HCN55_RS01565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCN55_RS01570	COG1714	RDD family
HCN55_RS01575	COG3012	SEC-C Motif Domain Protein
HCN55_RS01575	COG1405	negative regulation of cell septum assembly
HCN55_RS01580	COG3290	protein histidine kinase activity
HCN55_RS01585	COG3279	Response regulator of the LytR AlgR family
HCN55_RS01590	COG4555	ABC transporter
HCN55_RS01595	COG1668	transmembrane transport
HCN55_RS01600	COG0667	Aldo Keto reductase
HCN55_RS01615	COG1595	DNA-templated transcription, initiation
HCN55_RS01620	COG1595	DNA-templated transcription, initiation
HCN55_RS01625	COG1876	peptidase activity
HCN55_RS01630	COG0457	Tetratricopeptide repeat
HCN55_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS01640	COG0366	Alpha amylase catalytic
HCN55_RS01645	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCN55_RS01650	COG1121	(ABC) transporter
HCN55_RS01655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN55_RS01660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS01665	COG2310	stress, protein
HCN55_RS01670	COG2310	stress, protein
HCN55_RS01675	COG2310	stress, protein
HCN55_RS01680	COG0861	Integral membrane protein TerC family
HCN55_RS01690	COG3853	Toxic anion resistance protein (TelA)
HCN55_RS01695	COG0477	Major facilitator Superfamily
HCN55_RS01700	COG2814	Major facilitator Superfamily
HCN55_RS01705	COG0640	Transcriptional regulator
HCN55_RS01710	COG0517	IMP dehydrogenase activity
HCN55_RS01710	COG4175	Glycine betaine
HCN55_RS01715	COG4176	ABC-type proline glycine betaine transport system permease component
HCN55_RS01720	COG2113	Glycine betaine
HCN55_RS01730	COG1288	antiporter activity
HCN55_RS01740	COG0366	Alpha amylase catalytic
HCN55_RS01745	COG0039	L-malate dehydrogenase activity
HCN55_RS01750	COG1620	l-lactate permease
HCN55_RS01755	COG2814	Major facilitator Superfamily
HCN55_RS01760	COG1846	Transcriptional regulator
HCN55_RS01765	COG1280	lysine exporter protein (LysE YggA)
HCN55_RS01770	COG3403	YqcI/YcgG family
HCN55_RS01775	COG1113	amino acid transport
HCN55_RS01780	COG3665	Urea carboxylase-associated protein
HCN55_RS01785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HCN55_RS01790	COG1660	Displays ATPase and GTPase activities
HCN55_RS01795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HCN55_RS01800	COG2226	methyltransferase
HCN55_RS01805	COG0583	DNA-binding transcription factor activity
HCN55_RS01810	COG3458	cephalosporin-C deacetylase activity
HCN55_RS01815	COG3541	Predicted nucleotidyltransferase
HCN55_RS01820	COG0506	proline dehydrogenase activity
HCN55_RS01825	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS01830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN55_RS01835	COG2508	Transcriptional regulator
HCN55_RS01840	COG3689	TIGRFAM TIGR03943 family protein
HCN55_RS01845	COG0701	Predicted permease
HCN55_RS01850	COG2267	carboxylic ester hydrolase activity
HCN55_RS01855	COG0492	ferredoxin-NADP+ reductase activity
HCN55_RS01860	COG1587	Uroporphyrinogen-III synthase
HCN55_RS01860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCN55_RS01865	COG2146	nitrite reductase [NAD(P)H] activity
HCN55_RS01870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCN55_RS01875	COG0243	molybdopterin cofactor binding
HCN55_RS01880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCN55_RS01885	COG2223	nitrite transmembrane transporter activity
HCN55_RS01890	COG1469	GTP cyclohydrolase I activity
HCN55_RS01895	COG1376	ErfK ybiS ycfS ynhG family protein
HCN55_RS01905	COG0523	cobalamin synthesis protein
HCN55_RS01910	COG0765	amino acid transport
HCN55_RS01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS01925	COG1714	RDD family
HCN55_RS01935	COG2723	6-phospho-beta-galactosidase activity
HCN55_RS01945	COG3209	COG3209 Rhs family protein
HCN55_RS01950	COG3290	protein histidine kinase activity
HCN55_RS01950	COG0840	transmembrane signaling receptor activity
HCN55_RS01955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HCN55_RS01960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HCN55_RS01965	COG1733	regulation of RNA biosynthetic process
HCN55_RS01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HCN55_RS01990	COG2814	Major facilitator Superfamily
HCN55_RS02000	COG0697	spore germination
HCN55_RS02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS02015	COG2364	Membrane
HCN55_RS02020	COG1126	abc transporter atp-binding protein
HCN55_RS02025	COG0765	amino acid transport
HCN55_RS02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS02035	COG0583	DNA-binding transcription factor activity
HCN55_RS02040	COG0163	prenyltransferase activity
HCN55_RS02045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HCN55_RS02060	COG0596	Alpha beta hydrolase
HCN55_RS02065	COG3104	oligopeptide transport
HCN55_RS02070	COG5434	Belongs to the glycosyl hydrolase 28 family
HCN55_RS02080	COG0697	spore germination
HCN55_RS02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCN55_RS02095	COG1136	(ABC) transporter
HCN55_RS02100	COG0577	efflux transmembrane transporter activity
HCN55_RS02105	COG0745	RESPONSE REGULATOR receiver
HCN55_RS02110	COG5002	protein histidine kinase activity
HCN55_RS02110	COG3850	Histidine kinase
HCN55_RS02115	COG0457	Tetratricopeptide repeat
HCN55_RS02135	COG0527	aspartate kinase activity
HCN55_RS02140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS02145	COG4605	iron ion homeostasis
HCN55_RS02150	COG4604	ABC transporter, ATP-binding protein
HCN55_RS02155	COG4607	ABC-type enterochelin transport system periplasmic component
HCN55_RS02160	COG2814	Major facilitator Superfamily
HCN55_RS02165	COG1309	transcriptional regulator
HCN55_RS02170	COG0778	Nitroreductase
HCN55_RS02175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCN55_RS02180	COG0640	Transcriptional regulator
HCN55_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCN55_RS02195	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS02200	COG4975	Glucose uptake
HCN55_RS02205	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS02210	COG4549	nuclear export factor GLE1
HCN55_RS02215	COG2372	response to copper ion
HCN55_RS02215	COG1276	copper resistance
HCN55_RS02220	COG1349	DNA-binding transcription factor activity
HCN55_RS02230	COG2213	PTS system mannitol-specific
HCN55_RS02235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS02240	COG0246	Mannitol dehydrogenase
HCN55_RS02245	COG0473	3-isopropylmalate dehydrogenase activity
HCN55_RS02250	COG0681	Belongs to the peptidase S26 family
HCN55_RS02255	COG0412	Dienelactone hydrolase
HCN55_RS02260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN55_RS02270	COG0561	phosphatase activity
HCN55_RS02275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HCN55_RS02280	COG1914	H( )-stimulated, divalent metal cation uptake system
HCN55_RS02285	COG4336	lyase activity
HCN55_RS02290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCN55_RS02295	COG1984	allophanate hydrolase subunit 2
HCN55_RS02300	COG1414	Transcriptional regulator
HCN55_RS02305	COG2755	lipolytic protein G-D-S-L family
HCN55_RS02315	COG2329	Antibiotic biosynthesis monooxygenase
HCN55_RS02320	COG0768	penicillin binding
HCN55_RS02325	COG4989	oxidoreductase activity
HCN55_RS02330	COG3711	transcriptional antiterminator
HCN55_RS02335	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS02340	COG2226	methyltransferase
HCN55_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS02350	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS02360	COG3871	stress protein (general stress protein 26)
HCN55_RS02370	COG2814	Major facilitator Superfamily
HCN55_RS02375	COG1522	sequence-specific DNA binding
HCN55_RS02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCN55_RS02380	COG0551	DNA topoisomerase type I activity
HCN55_RS02385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCN55_RS02390	COG3706	GGDEF domain
HCN55_RS02395	COG5298	Protein conserved in bacteria
HCN55_RS02400	COG1215	transferase activity, transferring glycosyl groups
HCN55_RS02410	COG0531	amino acid
HCN55_RS02415	COG0494	nUDIX hydrolase
HCN55_RS02420	COG0028	Belongs to the TPP enzyme family
HCN55_RS02435	COG1914	H( )-stimulated, divalent metal cation uptake system
HCN55_RS02440	COG2261	transglycosylase associated protein
HCN55_RS02445	COG4876	unkown
HCN55_RS02450	COG2217	Heavy metal translocating P-type atpase
HCN55_RS02455	COG3729	General stress protein
HCN55_RS02460	COG0662	Cupin 2, conserved barrel domain protein
HCN55_RS02465	COG2329	Antibiotic biosynthesis monooxygenase
HCN55_RS02470	COG3546	catalase activity
HCN55_RS02475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HCN55_RS02480	COG3290	protein histidine kinase activity
HCN55_RS02485	COG4565	transcriptional regulatory protein
HCN55_RS02490	COG1301	dicarboxylic acid transport
HCN55_RS02495	COG0628	permease
HCN55_RS02500	COG1131	(ABC) transporter
HCN55_RS02505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCN55_RS02515	COG1960	acyl-CoA dehydrogenase activity
HCN55_RS02530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCN55_RS02535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS02540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCN55_RS02545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCN55_RS02550	COG0513	Belongs to the DEAD box helicase family
HCN55_RS02555	COG3402	PFAM membrane-flanked domain
HCN55_RS02560	COG3428	Bacterial PH domain
HCN55_RS02565	COG0705	Rhomboid family
HCN55_RS02570	COG0736	holo-[acyl-carrier-protein] synthase activity
HCN55_RS02575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCN55_RS02580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCN55_RS02585	COG0864	Transcriptional regulator
HCN55_RS02590	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCN55_RS02595	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS02600	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS02605	COG2172	sigma factor antagonist activity
HCN55_RS02610	COG2208	phosphoserine phosphatase activity
HCN55_RS02615	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS02620	COG2172	sigma factor antagonist activity
HCN55_RS02625	COG1191	sigma factor activity
HCN55_RS02630	COG2208	phosphoserine phosphatase activity
HCN55_RS02645	COG1673	EVE domain
HCN55_RS02650	COG1846	Transcriptional regulator
HCN55_RS02655	COG2183	response to ionizing radiation
HCN55_RS02665	COG3091	SprT-like family
HCN55_RS02705	COG0582	viral genome integration into host DNA
HCN55_RS02710	COG2856	Zn peptidase
HCN55_RS02715	COG1396	sequence-specific DNA binding
HCN55_RS02745	COG1674	ftsk spoiiie
HCN55_RS02750	COG2946	Replication initiation factor
HCN55_RS02785	COG0433	COG0433 Predicted ATPase
HCN55_RS02795	COG5644	endopeptidase inhibitor activity
HCN55_RS02800	COG0791	NLP P60 protein
HCN55_RS02800	COG0741	lytic transglycosylase activity
HCN55_RS02820	COG0457	Tetratricopeptide repeat
HCN55_RS02835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS02840	COG1522	sequence-specific DNA binding
HCN55_RS02845	COG1522	sequence-specific DNA binding
HCN55_RS02850	COG1335	isochorismatase
HCN55_RS02855	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCN55_RS02860	COG2814	Major facilitator Superfamily
HCN55_RS02880	COG0693	protein deglycase activity
HCN55_RS02885	COG1278	Cold shock
HCN55_RS02900	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS02900	COG2207	Transcriptional regulator
HCN55_RS02905	COG0697	spore germination
HCN55_RS02910	COG3708	Transcriptional regulator
HCN55_RS02910	COG2207	Transcriptional regulator
HCN55_RS02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS02920	COG0477	Major facilitator Superfamily
HCN55_RS02930	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HCN55_RS02940	COG0697	spore germination
HCN55_RS02945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS02950	COG2030	dehydratase
HCN55_RS02955	COG3545	Serine hydrolase
HCN55_RS02960	COG1733	regulation of RNA biosynthetic process
HCN55_RS02965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS02970	COG1733	regulation of RNA biosynthetic process
HCN55_RS02975	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN55_RS02980	COG2814	Major facilitator Superfamily
HCN55_RS02985	COG1309	transcriptional regulator
HCN55_RS02990	COG0640	Transcriptional regulator
HCN55_RS02995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCN55_RS03005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS03010	COG0697	spore germination
HCN55_RS03015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS03020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCN55_RS03025	COG0640	Transcriptional regulator
HCN55_RS03030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCN55_RS03045	COG4585	Histidine kinase
HCN55_RS03050	COG2197	response regulator
HCN55_RS03055	COG2409	Drug exporters of the RND superfamily
HCN55_RS03060	COG0596	Alpha beta hydrolase
HCN55_RS03065	COG1811	Na channel or pump
HCN55_RS03070	COG0789	Transcriptional regulator
HCN55_RS03070	COG4978	Transcriptional regulator
HCN55_RS03075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCN55_RS03080	COG0778	Nitroreductase
HCN55_RS03085	COG0346	lactoylglutathione lyase activity
HCN55_RS03090	COG2259	Doxx family
HCN55_RS03095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS03115	COG2323	membrane
HCN55_RS03120	COG2323	membrane
HCN55_RS03125	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN55_RS03140	COG1309	transcriptional regulator
HCN55_RS03150	COG0456	acetyltransferase
HCN55_RS03160	COG1113	amino acid transport
HCN55_RS03165	COG2318	DinB family
HCN55_RS03170	COG1846	Transcriptional regulator
HCN55_RS03175	COG2409	Drug exporters of the RND superfamily
HCN55_RS03175	COG1033	growth of symbiont in host cell
HCN55_RS03180	COG0778	Nitroreductase
HCN55_RS03185	COG1846	Transcriptional regulator
HCN55_RS03190	COG2814	Major facilitator Superfamily
HCN55_RS03195	COG0730	response to heat
HCN55_RS03200	COG1802	Transcriptional regulator
HCN55_RS03205	COG3858	chitin binding
HCN55_RS03205	COG1388	LysM domain
HCN55_RS03210	COG1819	glycosyl
HCN55_RS03220	COG1785	Belongs to the alkaline phosphatase family
HCN55_RS03225	COG5646	InterPro IPR014922
HCN55_RS03235	COG0454	-acetyltransferase
HCN55_RS03240	COG1078	dGTPase activity
HCN55_RS03245	COG1388	LysM domain
HCN55_RS03250	COG2814	Major facilitator Superfamily
HCN55_RS03255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCN55_RS03260	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCN55_RS03265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCN55_RS03270	COG2723	6-phospho-beta-galactosidase activity
HCN55_RS03275	COG2188	Transcriptional regulator
HCN55_RS03280	COG1940	carbohydrate kinase activity
HCN55_RS03285	COG1482	cell wall glycoprotein biosynthetic process
HCN55_RS03290	COG4124	Belongs to the glycosyl hydrolase 26 family
HCN55_RS03335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HCN55_RS03340	COG0802	atpase or kinase
HCN55_RS03345	COG1214	PFAM Peptidase M22, glycoprotease
HCN55_RS03350	COG0456	acetyltransferase
HCN55_RS03355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HCN55_RS03360	COG0488	(ABC) transporter
HCN55_RS03365	COG0315	cyclic pyranopterin monophosphate synthase activity
HCN55_RS03370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HCN55_RS03375	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HCN55_RS03380	COG0805	protein transport
HCN55_RS03390	COG1266	CAAX protease self-immunity
HCN55_RS03400	COG0459	protein refolding
HCN55_RS03410	COG3378	Phage plasmid primase P4 family
HCN55_RS03425	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCN55_RS03430	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCN55_RS03445	COG1401	restriction endodeoxyribonuclease activity
HCN55_RS03465	COG0457	Tetratricopeptide repeat
HCN55_RS03470	COG1063	alcohol dehydrogenase
HCN55_RS03475	COG2211	Major facilitator Superfamily
HCN55_RS03480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN55_RS03485	COG1842	Phage shock protein A
HCN55_RS03490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCN55_RS03495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HCN55_RS03500	COG4260	virion core protein, lumpy skin disease virus
HCN55_RS03510	COG2814	Major facilitator Superfamily
HCN55_RS03515	COG1063	alcohol dehydrogenase
HCN55_RS03520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HCN55_RS03525	COG0823	Involved in the tonB-independent uptake of proteins
HCN55_RS03540	COG2267	carboxylic ester hydrolase activity
HCN55_RS03550	COG2132	Multicopper oxidase
HCN55_RS03555	COG1113	amino acid transport
HCN55_RS03565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCN55_RS03570	COG0714	Associated with various cellular activities
HCN55_RS03575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HCN55_RS03580	COG1305	Transglutaminase-like
HCN55_RS03585	COG0519	Catalyzes the synthesis of GMP from XMP
HCN55_RS03585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HCN55_RS03590	COG2252	PERMEase
HCN55_RS03595	COG3064	Membrane
HCN55_RS03605	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HCN55_RS03615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCN55_RS03620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCN55_RS03625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCN55_RS03630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HCN55_RS03635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCN55_RS03640	COG0047	phosphoribosylformylglycinamidine synthase activity
HCN55_RS03645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCN55_RS03650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCN55_RS03655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HCN55_RS03660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCN55_RS03665	COG0138	bifunctional purine biosynthesis protein purh
HCN55_RS03670	COG0151	Belongs to the GarS family
HCN55_RS03675	COG1522	sequence-specific DNA binding
HCN55_RS03680	COG0531	amino acid
HCN55_RS03690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCN55_RS03695	COG1470	cell adhesion involved in biofilm formation
HCN55_RS03700	COG4496	protein, YerC YecD
HCN55_RS03705	COG0069	glutamate synthase activity
HCN55_RS03710	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HCN55_RS03715	COG0210	DNA helicase
HCN55_RS03720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HCN55_RS03725	COG4851	CamS sex pheromone cAM373 precursor
HCN55_RS03730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCN55_RS03735	COG1285	pathogenesis
HCN55_RS03740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN55_RS03745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCN55_RS03750	COG0154	amidase activity
HCN55_RS03755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HCN55_RS03760	COG1309	transcriptional regulator
HCN55_RS03765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCN55_RS03770	COG1597	lipid kinase activity
HCN55_RS03775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN55_RS03780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCN55_RS03785	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCN55_RS03790	COG1002	Type II restriction enzyme, methylase subunits
HCN55_RS03795	COG1061	Type III restriction enzyme res subunit
HCN55_RS03800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCN55_RS03820	COG5444	nuclease activity
HCN55_RS03825	COG3391	amine dehydrogenase activity
HCN55_RS03830	COG0457	Tetratricopeptide repeat
HCN55_RS03840	COG0217	transcriptional regulatory protein
HCN55_RS03850	COG1309	transcriptional regulator
HCN55_RS03855	COG3631	Ketosteroid isomerase-related protein
HCN55_RS03860	COG0702	epimerase
HCN55_RS03875	COG3546	catalase activity
HCN55_RS03880	COG0454	-acetyltransferase
HCN55_RS03890	COG5578	integral membrane protein
HCN55_RS03895	COG2972	Histidine kinase
HCN55_RS03900	COG4753	response regulator
HCN55_RS03900	COG2207	Transcriptional regulator
HCN55_RS03905	COG1653	transport
HCN55_RS03910	COG1175	transmembrane transport
HCN55_RS03915	COG0395	ABC-type sugar transport system, permease component
HCN55_RS03920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCN55_RS03925	COG2207	Transcriptional regulator
HCN55_RS03930	COG2755	lipolytic protein G-D-S-L family
HCN55_RS03940	COG5578	integral membrane protein
HCN55_RS03945	COG3401	FG-GAP repeat protein
HCN55_RS03950	COG3401	FG-GAP repeat protein
HCN55_RS03955	COG2755	lipolytic protein G-D-S-L family
HCN55_RS03960	COG1874	Beta-galactosidase
HCN55_RS03970	COG1653	transport
HCN55_RS03975	COG4209	transmembrane transport
HCN55_RS03980	COG0395	ABC-type sugar transport system, permease component
HCN55_RS03985	COG1486	melibiose metabolic process
HCN55_RS03990	COG2323	membrane
HCN55_RS03995	COG2329	Antibiotic biosynthesis monooxygenase
HCN55_RS04000	COG0346	lactoylglutathione lyase activity
HCN55_RS04015	COG5583	Uncharacterized small protein (DUF2292)
HCN55_RS04020	COG0670	Belongs to the BI1 family
HCN55_RS04025	COG0697	spore germination
HCN55_RS04030	COG1846	Transcriptional regulator
HCN55_RS04035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCN55_RS04045	COG2124	cytochrome p450
HCN55_RS04045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCN55_RS04050	COG1368	sulfuric ester hydrolase activity
HCN55_RS04055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCN55_RS04060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN55_RS04065	COG1442	glycosyl transferase family 8
HCN55_RS04070	COG1216	Glycosyl transferase, family 2
HCN55_RS04075	COG1442	glycosyl transferase family 8
HCN55_RS04080	COG2223	nitrite transmembrane transporter activity
HCN55_RS04085	COG1011	Hydrolase
HCN55_RS04090	COG0531	amino acid
HCN55_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS04100	COG0840	transmembrane signaling receptor activity
HCN55_RS04105	COG0488	(ABC) transporter
HCN55_RS04115	COG0789	Transcriptional regulator
HCN55_RS04120	COG2814	Major facilitator Superfamily
HCN55_RS04130	COG0488	(ABC) transporter
HCN55_RS04135	COG0513	Belongs to the DEAD box helicase family
HCN55_RS04140	COG0456	acetyltransferase
HCN55_RS04145	COG2130	NADP-dependent
HCN55_RS04150	COG2211	Major facilitator Superfamily
HCN55_RS04155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HCN55_RS04160	COG1120	ATPase activity
HCN55_RS04165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS04170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS04175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCN55_RS04190	COG3866	Pectate lyase
HCN55_RS04195	COG0471	metal ion transport
HCN55_RS04200	COG3290	protein histidine kinase activity
HCN55_RS04205	COG4565	transcriptional regulatory protein
HCN55_RS04210	COG3181	Tripartite tricarboxylate transporter family receptor
HCN55_RS04215	COG2851	Citrate transporter
HCN55_RS04220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS04225	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCN55_RS04230	COG1254	Belongs to the acylphosphatase family
HCN55_RS04235	COG2258	MOSC domain
HCN55_RS04255	COG0024	Methionine aminopeptidase
HCN55_RS04260	COG1263	PTS System
HCN55_RS04260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS04265	COG1368	sulfuric ester hydrolase activity
HCN55_RS04285	COG0531	amino acid
HCN55_RS04300	COG0697	spore germination
HCN55_RS04305	COG1263	PTS System
HCN55_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS04310	COG0366	Alpha amylase catalytic
HCN55_RS04315	COG2188	Transcriptional regulator
HCN55_RS04320	COG0778	Nitroreductase
HCN55_RS04325	COG0737	Belongs to the 5'-nucleotidase family
HCN55_RS04330	COG0693	protein deglycase activity
HCN55_RS04335	COG2814	Major facilitator Superfamily
HCN55_RS04340	COG4840	Belongs to the UPF0435 family
HCN55_RS04345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN55_RS04350	COG4980	gas vesicle protein
HCN55_RS04355	COG1295	ribonuclease BN
HCN55_RS04360	COG0477	Major facilitator Superfamily
HCN55_RS04365	COG0387	Pfam Sodium calcium exchanger
HCN55_RS04375	COG0668	transmembrane transport
HCN55_RS04380	COG0535	radical SAM domain protein
HCN55_RS04390	COG0726	polysaccharide deacetylase
HCN55_RS04395	COG2084	Dehydrogenase
HCN55_RS04400	COG0598	Magnesium transport protein CorA
HCN55_RS04405	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCN55_RS04410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCN55_RS04420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCN55_RS04425	COG4637	Psort location Cytoplasmic, score
HCN55_RS04435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCN55_RS04440	COG0022	dehydrogenase e1 component
HCN55_RS04445	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN55_RS04450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN55_RS04455	COG3284	Transcriptional regulator
HCN55_RS04465	COG1742	UPF0060 membrane protein
HCN55_RS04490	COG4842	Belongs to the WXG100 family
HCN55_RS04495	COG1486	melibiose metabolic process
HCN55_RS04500	COG1737	Transcriptional regulator
HCN55_RS04505	COG1263	PTS System
HCN55_RS04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS04510	COG1132	(ABC) transporter
HCN55_RS04515	COG1132	(ABC) transporter
HCN55_RS04520	COG2259	Doxx family
HCN55_RS04525	COG2514	catechol 2,3-dioxygenase activity
HCN55_RS04530	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS04530	COG4977	sequence-specific DNA binding
HCN55_RS04535	COG2814	Major facilitator Superfamily
HCN55_RS04540	COG1082	Xylose isomerase domain protein TIM barrel
HCN55_RS04545	COG0673	inositol 2-dehydrogenase activity
HCN55_RS04550	COG4585	Histidine kinase
HCN55_RS04555	COG2197	response regulator
HCN55_RS04560	COG1131	(ABC) transporter
HCN55_RS04565	COG1511	domain protein
HCN55_RS04565	COG0842	Transport permease protein
HCN55_RS04570	COG0842	Transport permease protein
HCN55_RS04575	COG1695	Transcriptional regulator
HCN55_RS04580	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HCN55_RS04585	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HCN55_RS04590	COG1309	transcriptional regulator
HCN55_RS04595	COG2814	Major facilitator Superfamily
HCN55_RS04600	COG2318	DinB family
HCN55_RS04605	COG2814	Major facilitator Superfamily
HCN55_RS04610	COG1846	Transcriptional regulator
HCN55_RS04615	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCN55_RS04615	COG0392	lysyltransferase activity
HCN55_RS04620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS04625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS04630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS04635	COG0384	phenazine biosynthesis protein PhzF
HCN55_RS04640	COG0778	Nitroreductase
HCN55_RS04655	COG1090	epimerase
HCN55_RS04660	COG2137	regulation of response to DNA damage stimulus
HCN55_RS04670	COG2814	Major facilitator Superfamily
HCN55_RS04685	COG3103	Sh3 type 3 domain protein
HCN55_RS04690	COG5658	integral membrane protein
HCN55_RS04695	COG0596	Alpha beta hydrolase
HCN55_RS04700	COG0463	Glycosyl transferase, family 2
HCN55_RS04705	COG4485	Bacterial membrane protein, YfhO
HCN55_RS04710	COG1988	membrane-bound metal-dependent
HCN55_RS04715	COG1194	a g-specific adenine glycosylase
HCN55_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS04740	COG3557	Belongs to the UPF0374 family
HCN55_RS04745	COG1132	(ABC) transporter
HCN55_RS04750	COG4129	membrane
HCN55_RS04755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCN55_RS04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCN55_RS04765	COG0735	belongs to the Fur family
HCN55_RS04875	COG4326	sporulation control protein
HCN55_RS04885	COG5577	PFAM Coat F domain
HCN55_RS04890	COG3340	Belongs to the peptidase S51 family
HCN55_RS04895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HCN55_RS04900	COG0277	FAD linked oxidase domain protein
HCN55_RS04910	COG0753	catalase activity
HCN55_RS04915	COG1116	anion transmembrane transporter activity
HCN55_RS04920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCN55_RS04925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCN55_RS04930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS04940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HCN55_RS04950	COG1476	TRANSCRIPTIONal
HCN55_RS04960	COG3382	B3 4 domain protein
HCN55_RS04965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCN55_RS04975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCN55_RS04980	COG0789	Transcriptional regulator
HCN55_RS04985	COG1664	Polymer-forming cytoskeletal
HCN55_RS04990	COG1664	Polymer-forming cytoskeletal
HCN55_RS04995	COG2766	serine protein kinase
HCN55_RS05000	COG2718	Belongs to the UPF0229 family
HCN55_RS05005	COG1846	Transcriptional regulator
HCN55_RS05010	COG1566	PFAM secretion protein HlyD family protein
HCN55_RS05015	COG2814	Major facilitator Superfamily
HCN55_RS05020	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCN55_RS05040	COG1725	Transcriptional regulator
HCN55_RS05045	COG1131	(ABC) transporter
HCN55_RS05050	COG1131	(ABC) transporter
HCN55_RS05055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCN55_RS05060	COG1278	Cold shock
HCN55_RS05065	COG1464	Belongs to the NlpA lipoprotein family
HCN55_RS05070	COG3706	GGDEF domain
HCN55_RS05075	COG1823	symporter activity
HCN55_RS05095	COG5577	PFAM Coat F domain
HCN55_RS05100	COG0737	Belongs to the 5'-nucleotidase family
HCN55_RS05100	COG1525	nuclease
HCN55_RS05100	COG4085	toxin activity
HCN55_RS05105	COG3764	Sortase (surface protein transpeptidase)
HCN55_RS05110	COG0564	pseudouridine synthase activity
HCN55_RS05120	COG0517	IMP dehydrogenase activity
HCN55_RS05125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCN55_RS05130	COG3153	acetyltransferase
HCN55_RS05130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN55_RS05135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCN55_RS05140	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HCN55_RS05145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCN55_RS05150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HCN55_RS05155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCN55_RS05160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCN55_RS05165	COG4585	Histidine kinase
HCN55_RS05165	COG2203	Gaf domain
HCN55_RS05170	COG2197	response regulator
HCN55_RS05175	COG0431	NADPH-dependent FMN reductase
HCN55_RS05190	COG0791	NLP P60 protein
HCN55_RS05190	COG1388	LysM domain
HCN55_RS05195	COG1959	2 iron, 2 sulfur cluster binding
HCN55_RS05200	COG0668	transmembrane transport
HCN55_RS05205	COG2719	SpoVR family
HCN55_RS05210	COG1785	Belongs to the alkaline phosphatase family
HCN55_RS05215	COG0791	NLP P60 protein
HCN55_RS05215	COG1388	LysM domain
HCN55_RS05220	COG0583	DNA-binding transcription factor activity
HCN55_RS05225	COG0372	Belongs to the citrate synthase family
HCN55_RS05230	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS05235	COG0531	amino acid
HCN55_RS05240	COG0733	neurotransmitter:sodium symporter activity
HCN55_RS05245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS05250	COG0456	acetyltransferase
HCN55_RS05265	COG1595	DNA-templated transcription, initiation
HCN55_RS05270	COG0667	Aldo Keto reductase
HCN55_RS05275	COG0204	Acyl-transferase
HCN55_RS05280	COG1253	flavin adenine dinucleotide binding
HCN55_RS05285	COG0789	Transcriptional regulator
HCN55_RS05290	COG0436	Aminotransferase
HCN55_RS05295	COG1253	flavin adenine dinucleotide binding
HCN55_RS05300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCN55_RS05305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCN55_RS05310	COG0584	glycerophosphoryl diester phosphodiesterase
HCN55_RS05320	COG0668	transmembrane transport
HCN55_RS05325	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HCN55_RS05330	COG0726	polysaccharide deacetylase
HCN55_RS05335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN55_RS05340	COG1757	Na H antiporter
HCN55_RS05345	COG0589	response to stress
HCN55_RS05355	COG1132	(ABC) transporter
HCN55_RS05360	COG1132	(ABC) transporter
HCN55_RS05365	COG0702	epimerase
HCN55_RS05385	COG0189	ligase activity
HCN55_RS05390	COG0189	ligase activity
HCN55_RS05395	COG4399	Belongs to the UPF0754 family
HCN55_RS05400	COG3679	Belongs to the UPF0342 family
HCN55_RS05405	COG4335	DNA alkylation repair
HCN55_RS05410	COG0561	phosphatase activity
HCN55_RS05415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN55_RS05420	COG0475	glutathione-regulated potassium exporter activity
HCN55_RS05425	COG0490	domain, Protein
HCN55_RS05435	COG1024	Enoyl-CoA hydratase
HCN55_RS05445	COG4152	abc transporter atp-binding protein
HCN55_RS05450	COG1668	transmembrane transport
HCN55_RS05455	COG0420	3'-5' exonuclease activity
HCN55_RS05460	COG4717	serine-type aminopeptidase activity
HCN55_RS05465	COG3481	metal-dependent phosphohydrolase, HD sub domain
HCN55_RS05475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCN55_RS05505	COG1846	Transcriptional regulator
HCN55_RS05510	COG4980	gas vesicle protein
HCN55_RS05525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HCN55_RS05530	COG0537	adenosine 5'-monophosphoramidase activity
HCN55_RS05535	COG1131	(ABC) transporter
HCN55_RS05540	COG4473	ABC transporter
HCN55_RS05550	COG1473	amidohydrolase
HCN55_RS05555	COG3069	C4-dicarboxylate transmembrane transporter activity
HCN55_RS05565	COG2329	Antibiotic biosynthesis monooxygenase
HCN55_RS05570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCN55_RS05575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HCN55_RS05590	COG1309	transcriptional regulator
HCN55_RS05595	COG1511	domain protein
HCN55_RS05600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN55_RS05605	COG4377	Putative membrane peptidase family (DUF2324)
HCN55_RS05615	COG1363	Peptidase, m42
HCN55_RS05620	COG4405	Protein conserved in bacteria
HCN55_RS05625	COG1301	dicarboxylic acid transport
HCN55_RS05635	COG1234	tRNA 3'-trailer cleavage
HCN55_RS05640	COG0095	Lipoate-protein ligase
HCN55_RS05645	COG0702	epimerase
HCN55_RS05650	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS05660	COG0501	Belongs to the peptidase M48B family
HCN55_RS05665	COG1404	Belongs to the peptidase S8 family
HCN55_RS05670	COG0456	acetyltransferase
HCN55_RS05675	COG0604	alcohol dehydrogenase
HCN55_RS05680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCN55_RS05685	COG0406	alpha-ribazole phosphatase activity
HCN55_RS05690	COG0183	Belongs to the thiolase family
HCN55_RS05695	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS05700	COG1268	BioY protein
HCN55_RS05705	COG0840	transmembrane signaling receptor activity
HCN55_RS05710	COG0723	plastoquinol--plastocyanin reductase activity
HCN55_RS05710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN55_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS05725	COG4903	ComK protein
HCN55_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS05740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN55_RS05755	COG0398	Pfam SNARE associated Golgi protein
HCN55_RS05760	COG0681	Belongs to the peptidase S26 family
HCN55_RS05765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HCN55_RS05770	COG1846	Transcriptional regulator
HCN55_RS05775	COG0738	Major facilitator superfamily
HCN55_RS05780	COG0673	inositol 2-dehydrogenase activity
HCN55_RS05785	COG0561	phosphatase activity
HCN55_RS05790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN55_RS05795	COG1609	Transcriptional regulator
HCN55_RS05800	COG3180	Ammonia monooxygenase
HCN55_RS05805	COG0477	Major facilitator Superfamily
HCN55_RS05805	COG2814	Major facilitator Superfamily
HCN55_RS05810	COG4533	DNA binding
HCN55_RS05820	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCN55_RS05825	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HCN55_RS05830	COG1074	ATP-dependent DNA helicase activity
HCN55_RS05835	COG0420	3'-5' exonuclease activity
HCN55_RS05840	COG0419	ATPase involved in DNA repair
HCN55_RS05845	COG1403	HNH endonuclease
HCN55_RS05885	COG5337	Spore coat protein CotH
HCN55_RS05890	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCN55_RS05900	COG1404	Belongs to the peptidase S8 family
HCN55_RS05910	COG0367	asparagine synthase
HCN55_RS05915	COG2318	DinB family
HCN55_RS05920	COG1562	ergosterol biosynthetic process
HCN55_RS05925	COG0534	Mate efflux family protein
HCN55_RS05930	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS05930	COG2207	Transcriptional regulator
HCN55_RS05935	COG1609	Transcriptional regulator
HCN55_RS05940	COG0673	inositol 2-dehydrogenase activity
HCN55_RS05945	COG2318	DinB family
HCN55_RS05950	COG1279	arginine transmembrane transporter activity
HCN55_RS05955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCN55_RS05960	COG1357	PFAM Pentapeptide repeats (8 copies)
HCN55_RS05965	COG2267	carboxylic ester hydrolase activity
HCN55_RS05970	COG0529	Catalyzes the synthesis of activated sulfate
HCN55_RS05975	COG2046	Belongs to the sulfate adenylyltransferase family
HCN55_RS05980	COG0175	sulfate reduction
HCN55_RS05985	COG2045	Belongs to the ComB family
HCN55_RS05990	COG1809	phosphosulfolactate synthase activity
HCN55_RS05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS06000	COG4948	Mandelate Racemase Muconate Lactonizing
HCN55_RS06005	COG2814	Major facilitator Superfamily
HCN55_RS06010	COG0454	-acetyltransferase
HCN55_RS06015	COG2153	protein acetylation
HCN55_RS06020	COG0646	methionine synthase
HCN55_RS06020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCN55_RS06025	COG1666	GTP binding
HCN55_RS06030	COG2996	Protein conserved in bacteria
HCN55_RS06050	COG1695	Transcriptional regulator
HCN55_RS06065	COG3227	Zinc metalloprotease (Elastase)
HCN55_RS06070	COG1307	EDD domain protein, DegV family
HCN55_RS06075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS06095	COG0561	phosphatase activity
HCN55_RS06100	COG1073	alpha beta
HCN55_RS06105	COG2151	metal-sulfur cluster biosynthetic enzyme
HCN55_RS06115	COG0277	FAD linked oxidase domain protein
HCN55_RS06120	COG2271	Major facilitator Superfamily
HCN55_RS06125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HCN55_RS06130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HCN55_RS06140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN55_RS06145	COG0505	Belongs to the CarA family
HCN55_RS06150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCN55_RS06155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HCN55_RS06170	COG2267	carboxylic ester hydrolase activity
HCN55_RS06180	COG1744	ABC transporter substrate-binding protein PnrA-like
HCN55_RS06195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN55_RS06200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN55_RS06205	COG5504	Zn-dependent protease
HCN55_RS06210	COG0444	Belongs to the ABC transporter superfamily
HCN55_RS06215	COG4608	Belongs to the ABC transporter superfamily
HCN55_RS06225	COG0601	transmembrane transport
HCN55_RS06230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN55_RS06240	COG0180	Tryptophanyl-tRNA synthetase
HCN55_RS06245	COG4166	transmembrane transport
HCN55_RS06250	COG0601	transmembrane transport
HCN55_RS06255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN55_RS06260	COG0444	Belongs to the ABC transporter superfamily
HCN55_RS06265	COG4608	Belongs to the ABC transporter superfamily
HCN55_RS06270	COG2814	Major facilitator Superfamily
HCN55_RS06275	COG0456	acetyltransferase
HCN55_RS06280	COG1393	Belongs to the ArsC family
HCN55_RS06285	COG0861	Integral membrane protein TerC family
HCN55_RS06295	COG4862	establishment of competence for transformation
HCN55_RS06305	COG4469	Competence protein
HCN55_RS06310	COG1164	Oligoendopeptidase f
HCN55_RS06325	COG2346	COG2346, Truncated hemoglobins
HCN55_RS06330	COG0741	lytic transglycosylase activity
HCN55_RS06335	COG4116	CYTH
HCN55_RS06345	COG2357	RelA SpoT domain protein
HCN55_RS06350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCN55_RS06355	COG0564	pseudouridine synthase activity
HCN55_RS06360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HCN55_RS06365	COG0569	domain protein
HCN55_RS06365	COG0475	glutathione-regulated potassium exporter activity
HCN55_RS06370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCN55_RS06375	COG0352	thiamine-phosphate diphosphorylase activity
HCN55_RS06380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN55_RS06385	COG2104	thiamine diphosphate biosynthetic process
HCN55_RS06390	COG2022	thiamine diphosphate biosynthetic process
HCN55_RS06395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCN55_RS06400	COG0351	phosphomethylpyrimidine kinase
HCN55_RS06405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HCN55_RS06460	COG0210	DNA helicase
HCN55_RS06470	COG2153	protein acetylation
HCN55_RS06475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCN55_RS06480	COG2382	esterase
HCN55_RS06485	COG0626	cystathionine gamma-synthase activity
HCN55_RS06490	COG0626	cystathionine gamma-synthase activity
HCN55_RS06495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS06500	COG5505	Protein of unknown function (DUF819)
HCN55_RS06530	COG3677	Transposase
HCN55_RS06545	COG5484	DNA packaging
HCN55_RS06550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HCN55_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS06565	COG3711	transcriptional antiterminator
HCN55_RS06565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS06570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCN55_RS06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS06570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCN55_RS06575	COG1482	cell wall glycoprotein biosynthetic process
HCN55_RS06585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS06595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCN55_RS06610	COG0109	protoheme IX farnesyltransferase activity
HCN55_RS06620	COG0726	polysaccharide deacetylase
HCN55_RS06635	COG5504	Zn-dependent protease
HCN55_RS06640	COG2205	protein histidine kinase activity
HCN55_RS06650	COG3383	formate dehydrogenase (NAD+) activity
HCN55_RS06655	COG2427	Protein of unknown function (DUF1641)
HCN55_RS06665	COG1051	belongs to the nudix hydrolase family
HCN55_RS06675	COG2124	cytochrome p450
HCN55_RS06680	COG1819	glycosyl
HCN55_RS06690	COG1587	Uroporphyrinogen-III synthase
HCN55_RS06695	COG0390	transport system, permease component
HCN55_RS06700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCN55_RS06705	COG0697	spore germination
HCN55_RS06710	COG4297	protein containing double-stranded beta helix domain
HCN55_RS06720	COG1252	NADH dehydrogenase
HCN55_RS06725	COG1904	glucuronate isomerase
HCN55_RS06730	COG2211	Major facilitator Superfamily
HCN55_RS06735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HCN55_RS06740	COG1063	alcohol dehydrogenase
HCN55_RS06745	COG1312	Catalyzes the dehydration of D-mannonate
HCN55_RS06750	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS06755	COG2271	Major facilitator Superfamily
HCN55_RS06760	COG1609	Transcriptional regulator
HCN55_RS06765	COG0246	Mannitol dehydrogenase
HCN55_RS06770	COG2721	sulfolactate sulfo-lyase activity
HCN55_RS06775	COG0730	response to heat
HCN55_RS06780	COG2318	DinB family
HCN55_RS06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCN55_RS06790	COG0457	Tetratricopeptide repeat
HCN55_RS06800	COG2350	Protein conserved in bacteria
HCN55_RS06805	COG1388	LysM domain
HCN55_RS06805	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS06805	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS06815	COG4195	phage-related replication protein
HCN55_RS06820	COG3546	catalase activity
HCN55_RS06825	COG2856	Zn peptidase
HCN55_RS06830	COG1396	sequence-specific DNA binding
HCN55_RS06840	COG1522	sequence-specific DNA binding
HCN55_RS06845	COG1484	DNA-dependent DNA replication
HCN55_RS06865	COG1595	DNA-templated transcription, initiation
HCN55_RS06870	COG5484	DNA packaging
HCN55_RS06870	COG3728	DNA packaging
HCN55_RS06875	COG1783	phage Terminase large subunit
HCN55_RS06880	COG5518	Phage portal protein
HCN55_RS06885	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCN55_RS06890	COG4653	Phage capsid family
HCN55_RS06940	COG3953	SLT domain
HCN55_RS06940	COG5412	phage tail tape measure protein
HCN55_RS06945	COG1652	LysM domain
HCN55_RS06950	COG4193	domain, Protein
HCN55_RS06960	COG3628	GPW Gp25 family protein
HCN55_RS06965	COG3299	homolog of phage Mu protein gp47
HCN55_RS06970	COG3778	Protein conserved in bacteria
HCN55_RS07010	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS07010	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS07030	COG0306	phosphate transporter
HCN55_RS07035	COG1392	Phosphate transport regulator
HCN55_RS07040	COG0531	amino acid
HCN55_RS07045	COG0346	lactoylglutathione lyase activity
HCN55_RS07055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCN55_RS07060	COG0463	Glycosyl transferase, family 2
HCN55_RS07070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN55_RS07075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN55_RS07080	COG2362	D-Aminopeptidase
HCN55_RS07085	COG0601	transmembrane transport
HCN55_RS07090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCN55_RS07095	COG0444	Belongs to the ABC transporter superfamily
HCN55_RS07100	COG4166	transmembrane transport
HCN55_RS07105	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCN55_RS07110	COG4948	Mandelate Racemase Muconate Lactonizing
HCN55_RS07115	COG0791	NLP P60 protein
HCN55_RS07120	COG4608	Belongs to the ABC transporter superfamily
HCN55_RS07125	COG2706	6-phosphogluconolactonase activity
HCN55_RS07130	COG1834	amidinotransferase
HCN55_RS07135	COG1607	acyl-coa hydrolase
HCN55_RS07140	COG1017	nitric oxide dioxygenase activity
HCN55_RS07140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HCN55_RS07150	COG2323	membrane
HCN55_RS07155	COG2318	DinB family
HCN55_RS07160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS07165	COG2076	Multidrug Resistance protein
HCN55_RS07170	COG2076	Multidrug Resistance protein
HCN55_RS07175	COG0788	formyltetrahydrofolate deformylase activity
HCN55_RS07180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCN55_RS07185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HCN55_RS07190	COG1764	response to oxidative stress
HCN55_RS07195	COG1846	Transcriptional regulator
HCN55_RS07200	COG1764	response to oxidative stress
HCN55_RS07210	COG0590	tRNA wobble adenosine to inosine editing
HCN55_RS07215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCN55_RS07220	COG1404	Belongs to the peptidase S8 family
HCN55_RS07225	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS07230	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCN55_RS07235	COG1122	ATPase activity
HCN55_RS07240	COG4721	ABC-type cobalt transport system, permease component
HCN55_RS07250	COG0745	RESPONSE REGULATOR receiver
HCN55_RS07255	COG5002	protein histidine kinase activity
HCN55_RS07255	COG3850	Histidine kinase
HCN55_RS07260	COG3212	peptidase
HCN55_RS07265	COG3212	peptidase
HCN55_RS07275	COG2239	Acts as a magnesium transporter
HCN55_RS07280	COG0789	Transcriptional regulator
HCN55_RS07295	COG1846	Transcriptional regulator
HCN55_RS07300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN55_RS07305	COG0726	polysaccharide deacetylase
HCN55_RS07310	COG1408	metallophosphoesterase
HCN55_RS07320	COG0463	Glycosyl transferase, family 2
HCN55_RS07325	COG3285	dna ligase
HCN55_RS07325	COG1793	dna ligase
HCN55_RS07330	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HCN55_RS07335	COG3300	MHYT domain
HCN55_RS07335	COG5001	Diguanylate cyclase
HCN55_RS07340	COG0586	Pfam SNARE associated Golgi protein
HCN55_RS07345	COG0861	Integral membrane protein TerC family
HCN55_RS07350	COG1191	sigma factor activity
HCN55_RS07370	COG0501	Belongs to the peptidase M48B family
HCN55_RS07375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCN55_RS07390	COG3594	Acyltransferase
HCN55_RS07395	COG5002	protein histidine kinase activity
HCN55_RS07400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCN55_RS07410	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCN55_RS07415	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HCN55_RS07420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCN55_RS07425	COG0436	Aminotransferase
HCN55_RS07430	COG1850	ribulose-bisphosphate carboxylase activity
HCN55_RS07435	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HCN55_RS07440	COG0235	Class ii aldolase
HCN55_RS07445	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HCN55_RS07450	COG3339	Conserved Protein
HCN55_RS07465	COG3852	Histidine kinase
HCN55_RS07470	COG1846	Transcriptional regulator
HCN55_RS07475	COG1360	Flagellar Motor Protein
HCN55_RS07480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCN55_RS07485	COG0542	response to heat
HCN55_RS07490	COG3949	Membrane
HCN55_RS07495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HCN55_RS07500	COG0720	synthase
HCN55_RS07505	COG0602	queuosine metabolic process
HCN55_RS07510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HCN55_RS07515	COG1733	regulation of RNA biosynthetic process
HCN55_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS07525	COG1388	LysM domain
HCN55_RS07525	COG4641	Protein conserved in bacteria
HCN55_RS07530	COG1388	LysM domain
HCN55_RS07545	COG4873	Protein conserved in bacteria
HCN55_RS07555	COG3773	Cell wall hydrolase
HCN55_RS07560	COG2244	polysaccharide biosynthetic process
HCN55_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS07570	COG2217	Heavy metal translocating P-type atpase
HCN55_RS07580	COG0006	proline dipeptidase activity
HCN55_RS07585	COG1609	Transcriptional regulator
HCN55_RS07590	COG3711	transcriptional antiterminator
HCN55_RS07595	COG1263	PTS System
HCN55_RS07595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS07595	COG2190	(PTS) system
HCN55_RS07600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS07605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HCN55_RS07615	COG1533	DNA photolyase activity
HCN55_RS07620	COG0456	acetyltransferase
HCN55_RS07625	COG0840	transmembrane signaling receptor activity
HCN55_RS07630	COG2084	Dehydrogenase
HCN55_RS07635	COG2340	Cysteine-rich secretory protein family
HCN55_RS07640	COG0768	penicillin binding
HCN55_RS07645	COG4191	Histidine kinase
HCN55_RS07650	COG0436	Aminotransferase
HCN55_RS07660	COG0835	chemotaxis
HCN55_RS07660	COG0784	Response regulator, receiver
HCN55_RS07670	COG2814	Major facilitator Superfamily
HCN55_RS07675	COG1376	ErfK ybiS ycfS ynhG family protein
HCN55_RS07680	COG1408	metallophosphoesterase
HCN55_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS07690	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS07695	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS07705	COG2200	EAL domain
HCN55_RS07710	COG4703	Protein of unknown function (DUF1797)
HCN55_RS07715	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HCN55_RS07725	COG0517	IMP dehydrogenase activity
HCN55_RS07730	COG0583	DNA-binding transcription factor activity
HCN55_RS07735	COG0716	FMN binding
HCN55_RS07745	COG0716	FMN binding
HCN55_RS07750	COG2171	N-acyltransferase activity
HCN55_RS07755	COG1473	amidohydrolase
HCN55_RS07765	COG0668	transmembrane transport
HCN55_RS07770	COG0450	alkyl hydroperoxide reductase
HCN55_RS07775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS07790	COG0746	molybdenum cofactor guanylyltransferase activity
HCN55_RS07795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCN55_RS07800	COG0303	'Molybdopterin
HCN55_RS07805	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCN55_RS07810	COG0314	molybdopterin synthase activity
HCN55_RS07815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HCN55_RS07820	COG1132	(ABC) transporter
HCN55_RS07825	COG1132	(ABC) transporter
HCN55_RS07835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN55_RS07840	COG1136	(ABC) transporter
HCN55_RS07845	COG0577	efflux transmembrane transporter activity
HCN55_RS07850	COG1349	DNA-binding transcription factor activity
HCN55_RS07855	COG1105	Belongs to the carbohydrate kinase PfkB family
HCN55_RS07860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCN55_RS07860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCN55_RS07860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS07865	COG0681	Belongs to the peptidase S26 family
HCN55_RS07875	COG0488	(ABC) transporter
HCN55_RS07880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCN55_RS07885	COG2309	aminopeptidase activity
HCN55_RS07895	COG1077	Cell shape determining protein MreB Mrl
HCN55_RS07900	COG2002	toxin-antitoxin pair type II binding
HCN55_RS07905	COG3852	Histidine kinase
HCN55_RS07910	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HCN55_RS07910	COG2105	PFAM AIG2 family protein
HCN55_RS07915	COG0569	domain protein
HCN55_RS07920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCN55_RS07925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCN55_RS07935	COG0561	phosphatase activity
HCN55_RS07940	COG0242	peptide deformylase activity
HCN55_RS07950	COG0497	DNA recombination
HCN55_RS07955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCN55_RS07960	COG0022	dehydrogenase e1 component
HCN55_RS07965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN55_RS07970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN55_RS07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS07985	COG1982	Orn Lys Arg decarboxylase major
HCN55_RS07990	COG4476	Belongs to the UPF0223 family
HCN55_RS07995	COG4493	Belongs to the UPF0637 family
HCN55_RS08005	COG0483	inositol monophosphate 1-phosphatase activity
HCN55_RS08015	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HCN55_RS08035	COG1595	DNA-templated transcription, initiation
HCN55_RS08065	COG4896	Protein conserved in bacteria
HCN55_RS08075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCN55_RS08080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCN55_RS08085	COG2066	Belongs to the glutaminase family
HCN55_RS08090	COG4838	Belongs to the UPF0358 family
HCN55_RS08095	COG0772	Belongs to the SEDS family
HCN55_RS08100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HCN55_RS08105	COG1612	heme a metabolic process
HCN55_RS08110	COG0109	protoheme IX farnesyltransferase activity
HCN55_RS08115	COG2010	Cytochrome c
HCN55_RS08115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCN55_RS08120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCN55_RS08125	COG1845	cytochrome c oxidase, subunit III
HCN55_RS08130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCN55_RS08135	COG3336	cytochrome c oxidase
HCN55_RS08145	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HCN55_RS08150	COG2340	Cysteine-rich secretory protein family
HCN55_RS08165	COG3679	Belongs to the UPF0342 family
HCN55_RS08170	COG4471	UPF0298 protein
HCN55_RS08175	COG0742	ribosomal rna small subunit methyltransferase
HCN55_RS08180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HCN55_RS08185	COG3314	Sporulation integral membrane protein YlbJ
HCN55_RS08190	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCN55_RS08195	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCN55_RS08200	COG1323	Belongs to the UPF0348 family
HCN55_RS08210	COG1399	metal-binding, possibly nucleic acid-binding protein
HCN55_RS08225	COG0454	-acetyltransferase
HCN55_RS08230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCN55_RS08235	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HCN55_RS08240	COG2001	Belongs to the MraZ family
HCN55_RS08245	COG0275	rRNA processing
HCN55_RS08250	COG4839	cell division protein FtsL
HCN55_RS08260	COG0768	penicillin binding
HCN55_RS08265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCN55_RS08270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN55_RS08275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCN55_RS08280	COG0772	Belongs to the SEDS family
HCN55_RS08285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN55_RS08290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HCN55_RS08295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCN55_RS08300	COG3879	Bacterial protein of unknown function (DUF881)
HCN55_RS08305	COG3879	Bacterial protein of unknown function (DUF881)
HCN55_RS08310	COG3856	small basic protein
HCN55_RS08315	COG0849	cell division
HCN55_RS08320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCN55_RS08325	COG4412	M6 family metalloprotease domain protein
HCN55_RS08325	COG1404	Belongs to the peptidase S8 family
HCN55_RS08335	COG1191	sigma factor activity
HCN55_RS08340	COG1191	sigma factor activity
HCN55_RS08345	COG1119	ATPase activity
HCN55_RS08350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN55_RS08355	COG1873	PFAM PRC-barrel domain
HCN55_RS08365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCN55_RS08370	COG1799	cell septum assembly
HCN55_RS08375	COG0762	integral membrane protein
HCN55_RS08380	COG2302	S4 RNA-binding domain
HCN55_RS08385	COG3599	regulation of cell shape
HCN55_RS08390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HCN55_RS08395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCN55_RS08400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HCN55_RS08405	COG0564	pseudouridine synthase activity
HCN55_RS08410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HCN55_RS08415	COG2233	PERMEase
HCN55_RS08420	COG0540	Belongs to the ATCase OTCase family
HCN55_RS08425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HCN55_RS08430	COG0505	Belongs to the CarA family
HCN55_RS08435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HCN55_RS08440	COG0543	2 iron, 2 sulfur cluster binding
HCN55_RS08445	COG0167	dihydroorotate dehydrogenase activity
HCN55_RS08450	COG0284	orotidine-5'-phosphate decarboxylase activity
HCN55_RS08455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCN55_RS08460	COG0175	sulfate reduction
HCN55_RS08465	COG0306	phosphate transporter
HCN55_RS08470	COG2046	Belongs to the sulfate adenylyltransferase family
HCN55_RS08475	COG0529	Catalyzes the synthesis of activated sulfate
HCN55_RS08480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCN55_RS08485	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HCN55_RS08490	COG1648	precorrin-2 dehydrogenase activity
HCN55_RS08495	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HCN55_RS08500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCN55_RS08505	COG1561	YicC-like family, N-terminal region
HCN55_RS08515	COG0194	GDP metabolic process
HCN55_RS08520	COG1758	RNA polymerase activity
HCN55_RS08525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCN55_RS08530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCN55_RS08535	COG0242	peptide deformylase activity
HCN55_RS08540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCN55_RS08545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN55_RS08545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCN55_RS08550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HCN55_RS08555	COG0631	protein serine/threonine phosphatase activity
HCN55_RS08560	COG0515	serine threonine protein kinase
HCN55_RS08560	COG2815	serine threonine protein kinase
HCN55_RS08565	COG1162	GTPase activity
HCN55_RS08570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCN55_RS08575	COG1564	THIamine pyrophosphokinase
HCN55_RS08585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HCN55_RS08590	COG1302	Protein conserved in bacteria
HCN55_RS08595	COG1461	Dihydroxyacetone kinase
HCN55_RS08600	COG1760	l-serine dehydratase
HCN55_RS08605	COG1760	l-serine dehydratase
HCN55_RS08610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCN55_RS08615	COG1349	DNA-binding transcription factor activity
HCN55_RS08615	COG2050	protein possibly involved in aromatic compounds catabolism
HCN55_RS08620	COG0416	fatty acid biosynthetic process
HCN55_RS08625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN55_RS08630	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS08640	COG0571	ribonuclease III activity
HCN55_RS08645	COG1196	nuclear chromosome segregation
HCN55_RS08650	COG0552	protein localization to endoplasmic reticulum
HCN55_RS08660	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HCN55_RS08665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCN55_RS08670	COG0228	four-way junction DNA binding
HCN55_RS08675	COG1837	Belongs to the UPF0109 family
HCN55_RS08685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HCN55_RS08690	COG0336	Belongs to the RNA methyltransferase TrmD family
HCN55_RS08695	COG0335	large ribosomal subunit rRNA binding
HCN55_RS08700	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCN55_RS08705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCN55_RS08715	COG2257	FlhB HrpN YscU SpaS Family
HCN55_RS08720	COG0045	succinate-CoA ligase (ADP-forming) activity
HCN55_RS08725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCN55_RS08730	COG0758	DNA mediated transformation
HCN55_RS08735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCN55_RS08740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HCN55_RS08745	COG4974	Belongs to the 'phage' integrase family
HCN55_RS08750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HCN55_RS08755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HCN55_RS08760	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HCN55_RS08765	COG1815	bacterial-type flagellum-dependent cell motility
HCN55_RS08770	COG1558	bacterial-type flagellum-dependent cell motility
HCN55_RS08775	COG1677	Flagellar hook-basal body complex protein FliE
HCN55_RS08780	COG1766	The M ring may be actively involved in energy transduction
HCN55_RS08785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN55_RS08790	COG1317	bacterial-type flagellum organization
HCN55_RS08795	COG1157	protein secretion by the type III secretion system
HCN55_RS08800	COG2882	bacterial-type flagellum organization
HCN55_RS08805	COG3334	PFAM MgtE intracellular
HCN55_RS08810	COG3144	bacterial-type flagellum assembly
HCN55_RS08815	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HCN55_RS08820	COG4786	Flagellar basal body rod
HCN55_RS08825	COG1582	Flagellar protein (FlbD)
HCN55_RS08830	COG1580	Controls the rotational direction of flagella during chemotaxis
HCN55_RS08835	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN55_RS08840	COG1776	CheC inhibitor of MCP methylation
HCN55_RS08840	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCN55_RS08845	COG2201	protein-glutamate methylesterase activity
HCN55_RS08850	COG3190	flagellar
HCN55_RS08855	COG1338	Plays a role in the flagellum-specific transport system
HCN55_RS08860	COG1987	bacterial-type flagellum assembly
HCN55_RS08865	COG1684	flagellar biosynthetic protein fliR
HCN55_RS08870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCN55_RS08875	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCN55_RS08880	COG1419	protein localization to endoplasmic reticulum
HCN55_RS08885	COG0455	bacterial-type flagellum organization
HCN55_RS08890	COG2201	protein-glutamate methylesterase activity
HCN55_RS08895	COG0643	Histidine kinase
HCN55_RS08895	COG2198	Histidine kinase
HCN55_RS08900	COG0835	chemotaxis
HCN55_RS08905	COG1776	CheC inhibitor of MCP methylation
HCN55_RS08910	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HCN55_RS08915	COG1191	sigma factor activity
HCN55_RS08925	COG0052	Belongs to the universal ribosomal protein uS2 family
HCN55_RS08930	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HCN55_RS08935	COG0528	UMP kinase activity
HCN55_RS08940	COG0233	cytoplasmic translational termination
HCN55_RS08945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HCN55_RS08950	COG4589	Belongs to the CDS family
HCN55_RS08955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HCN55_RS08960	COG0750	zinc metalloprotease
HCN55_RS08965	COG0442	prolyl-tRNA aminoacylation
HCN55_RS08970	COG2176	DNA-directed DNA polymerase activity
HCN55_RS08975	COG0779	Required for maturation of 30S ribosomal subunits
HCN55_RS08980	COG0195	Participates in both transcription termination and antitermination
HCN55_RS08985	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HCN55_RS08990	COG1358	cellular component organization or biogenesis
HCN55_RS08995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HCN55_RS09000	COG1550	Protein conserved in bacteria
HCN55_RS09005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HCN55_RS09010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HCN55_RS09015	COG0196	riboflavin kinase activity
HCN55_RS09020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HCN55_RS09025	COG1185	polyribonucleotide nucleotidyltransferase activity
HCN55_RS09030	COG0726	polysaccharide deacetylase
HCN55_RS09035	COG0612	Peptidase, M16
HCN55_RS09040	COG1873	PFAM PRC-barrel domain
HCN55_RS09045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN55_RS09050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCN55_RS09055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCN55_RS09060	COG0527	aspartate kinase activity
HCN55_RS09065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCN55_RS09070	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCN55_RS09075	COG0740	serine-type endopeptidase activity
HCN55_RS09085	COG4980	gas vesicle protein
HCN55_RS09085	COG1674	ftsk spoiiie
HCN55_RS09090	COG2188	Transcriptional regulator
HCN55_RS09095	COG2814	Major facilitator Superfamily
HCN55_RS09100	COG0612	Peptidase, M16
HCN55_RS09105	COG0612	Peptidase, M16
HCN55_RS09110	COG0300	oxidoreductase activity
HCN55_RS09125	COG1426	Protein conserved in bacteria
HCN55_RS09130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCN55_RS09135	COG1058	Belongs to the CinA family
HCN55_RS09135	COG1546	Belongs to the CinA family
HCN55_RS09140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HCN55_RS09145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCN55_RS09150	COG1418	mRNA catabolic process
HCN55_RS09155	COG1692	metallophosphoesterase
HCN55_RS09160	COG2359	stage V sporulation protein S
HCN55_RS09165	COG1063	alcohol dehydrogenase
HCN55_RS09170	COG0156	8-amino-7-oxononanoate synthase activity
HCN55_RS09175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN55_RS09180	COG4550	Control of competence regulator ComK, YlbF/YmcA
HCN55_RS09190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HCN55_RS09195	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HCN55_RS09210	COG3226	Transcriptional regulator
HCN55_RS09215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS09225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN55_RS09230	COG3321	synthase
HCN55_RS09235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCN55_RS09235	COG2070	2-Nitropropane dioxygenase
HCN55_RS09240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN55_RS09245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCN55_RS09250	COG3425	synthase
HCN55_RS09255	COG1024	Enoyl-CoA hydratase
HCN55_RS09260	COG1024	Enoyl-CoA hydratase
HCN55_RS09265	COG3321	synthase
HCN55_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09265	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS09265	COG0300	oxidoreductase activity
HCN55_RS09270	COG4221	oxidoreductase activity
HCN55_RS09270	COG3321	synthase
HCN55_RS09270	COG0300	oxidoreductase activity
HCN55_RS09270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN55_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN55_RS09275	COG3321	synthase
HCN55_RS09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN55_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS09275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09280	COG4221	oxidoreductase activity
HCN55_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS09280	COG3321	synthase
HCN55_RS09285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HCN55_RS09285	COG3321	synthase
HCN55_RS09285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN55_RS09285	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCN55_RS09290	COG2124	cytochrome p450
HCN55_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS09305	COG1404	Belongs to the peptidase S8 family
HCN55_RS09310	COG4195	phage-related replication protein
HCN55_RS09315	COG1764	response to oxidative stress
HCN55_RS09320	COG2076	Multidrug Resistance protein
HCN55_RS09325	COG2076	Multidrug Resistance protein
HCN55_RS09340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HCN55_RS09345	COG1923	regulation of RNA biosynthetic process
HCN55_RS09360	COG1780	Probably involved in ribonucleotide reductase function
HCN55_RS09365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN55_RS09370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN55_RS09375	COG4112	unkown
HCN55_RS09380	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS09385	COG0464	growth
HCN55_RS09390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCN55_RS09395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCN55_RS09400	COG0789	Transcriptional regulator
HCN55_RS09405	COG0174	glutamine synthetase
HCN55_RS09425	COG4282	regulation of fungal-type cell wall biogenesis
HCN55_RS09435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS09465	COG0135	phosphoribosylanthranilate isomerase activity
HCN55_RS09470	COG2211	Major facilitator Superfamily
HCN55_RS09475	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN55_RS09480	COG1940	carbohydrate kinase activity
HCN55_RS09485	COG2115	Belongs to the xylose isomerase family
HCN55_RS09490	COG1070	Carbohydrate kinase
HCN55_RS09500	COG1525	nuclease
HCN55_RS09505	COG2814	Major facilitator Superfamily
HCN55_RS09510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCN55_RS09520	COG0756	dUTP diphosphatase activity
HCN55_RS09535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCN55_RS09575	COG3832	glyoxalase III activity
HCN55_RS09585	COG0697	spore germination
HCN55_RS09590	COG0531	amino acid
HCN55_RS09620	COG4195	phage-related replication protein
HCN55_RS09630	COG0346	lactoylglutathione lyase activity
HCN55_RS09635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HCN55_RS09640	COG1388	LysM domain
HCN55_RS09645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCN55_RS09650	COG4224	UPF0291 protein
HCN55_RS09655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HCN55_RS09665	COG3763	UPF0154 protein
HCN55_RS09675	COG0785	Cytochrome C biogenesis protein
HCN55_RS09680	COG2201	protein-glutamate methylesterase activity
HCN55_RS09685	COG4846	Membrane protein involved in cytochrome C biogenesis
HCN55_RS09695	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN55_RS09710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCN55_RS09715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS09735	COG0824	Thioesterase
HCN55_RS09745	COG4841	protein insertion into membrane
HCN55_RS09750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HCN55_RS09755	COG1832	CoA-binding protein
HCN55_RS09760	COG0187	DNA topoisomerase II activity
HCN55_RS09765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCN55_RS09775	COG1115	amino acid carrier protein
HCN55_RS09790	COG5520	Belongs to the glycosyl hydrolase 30 family
HCN55_RS09795	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN55_RS09800	COG2246	polysaccharide biosynthetic process
HCN55_RS09805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCN55_RS09810	COG0586	Pfam SNARE associated Golgi protein
HCN55_RS09815	COG2404	hydrolase activity, acting on ester bonds
HCN55_RS09820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCN55_RS09825	COG1024	Enoyl-CoA hydratase
HCN55_RS09830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCN55_RS09835	COG0511	ligase activity, forming carbon-carbon bonds
HCN55_RS09840	COG0439	Biotin carboxylase
HCN55_RS09845	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS09850	COG1960	acyl-CoA dehydrogenase activity
HCN55_RS09865	COG1649	PFAM Uncharacterised BCR, COG1649
HCN55_RS09875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09875	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HCN55_RS09880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS09900	COG2027	D-alanyl-D-alanine carboxypeptidase
HCN55_RS09905	COG2017	converts alpha-aldose to the beta-anomer
HCN55_RS09910	COG0534	Mate efflux family protein
HCN55_RS09925	COG0582	viral genome integration into host DNA
HCN55_RS09930	COG0166	Belongs to the GPI family
HCN55_RS09935	COG0405	Gamma-glutamyltransferase
HCN55_RS09940	COG0583	DNA-binding transcription factor activity
HCN55_RS09945	COG0604	alcohol dehydrogenase
HCN55_RS09950	COG0493	'glutamate synthase
HCN55_RS09955	COG0070	glutamate synthase
HCN55_RS09955	COG0067	glutamate synthase
HCN55_RS09955	COG0069	glutamate synthase activity
HCN55_RS09960	COG0583	DNA-binding transcription factor activity
HCN55_RS09965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HCN55_RS09970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN55_RS09980	COG0300	oxidoreductase activity
HCN55_RS09985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCN55_RS09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS10000	COG2814	Major facilitator Superfamily
HCN55_RS10005	COG1070	Carbohydrate kinase
HCN55_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCN55_RS10015	COG0243	molybdopterin cofactor binding
HCN55_RS10045	COG5278	phosphoserine phosphatase activity
HCN55_RS10045	COG0840	transmembrane signaling receptor activity
HCN55_RS10050	COG2368	4-hydroxyphenylacetate
HCN55_RS10055	COG4305	rare lipoprotein A
HCN55_RS10060	COG3619	membrane
HCN55_RS10065	COG3866	Pectate lyase
HCN55_RS10070	COG2135	peptidase activity
HCN55_RS10080	COG2140	Oxalate decarboxylase
HCN55_RS10095	COG0456	acetyltransferase
HCN55_RS10115	COG2720	vancomycin resistance protein
HCN55_RS10125	COG3655	Transcriptional regulator
HCN55_RS10130	COG3739	integral membrane protein
HCN55_RS10135	COG0583	DNA-binding transcription factor activity
HCN55_RS10140	COG0697	spore germination
HCN55_RS10150	COG0693	protein deglycase activity
HCN55_RS10155	COG2367	Beta-lactamase
HCN55_RS10180	COG0574	Belongs to the PEP-utilizing enzyme family
HCN55_RS10180	COG3848	Pyruvate phosphate dikinase
HCN55_RS10185	COG0726	polysaccharide deacetylase
HCN55_RS10190	COG2314	TM2 domain
HCN55_RS10195	COG1396	sequence-specific DNA binding
HCN55_RS10210	COG2135	peptidase activity
HCN55_RS10245	COG0457	Tetratricopeptide repeat
HCN55_RS10270	COG5290	Psort location Cytoplasmic, score
HCN55_RS10295	COG5444	nuclease activity
HCN55_RS10300	COG4282	regulation of fungal-type cell wall biogenesis
HCN55_RS10305	COG1231	oxidoreductase activity
HCN55_RS10310	COG5434	Belongs to the glycosyl hydrolase 28 family
HCN55_RS10315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN55_RS10320	COG0662	Cupin 2, conserved barrel domain protein
HCN55_RS10320	COG2207	Transcriptional regulator
HCN55_RS10325	COG0456	acetyltransferase
HCN55_RS10330	COG1309	transcriptional regulator
HCN55_RS10335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS10340	COG3708	Transcriptional regulator
HCN55_RS10345	COG2378	regulation of single-species biofilm formation
HCN55_RS10355	COG0640	Transcriptional regulator
HCN55_RS10360	COG0741	lytic transglycosylase activity
HCN55_RS10365	COG2322	membrane
HCN55_RS10380	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCN55_RS10385	COG3239	Fatty acid desaturase
HCN55_RS10390	COG4585	Histidine kinase
HCN55_RS10395	COG2197	response regulator
HCN55_RS10400	COG3584	3D domain protein
HCN55_RS10400	COG1388	LysM domain
HCN55_RS10405	COG0514	ATP-dependent DNA helicase (RecQ)
HCN55_RS10415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCN55_RS10420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCN55_RS10435	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN55_RS10460	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS10465	COG1657	PFAM Prenyltransferase squalene oxidase
HCN55_RS10470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCN55_RS10475	COG0733	neurotransmitter:sodium symporter activity
HCN55_RS10480	COG0385	Bile acid
HCN55_RS10485	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN55_RS10490	COG0567	Dehydrogenase, E1 component
HCN55_RS10495	COG4548	von Willebrand factor, type A
HCN55_RS10500	COG0714	Associated with various cellular activities
HCN55_RS10505	COG2032	superoxide dismutase activity
HCN55_RS10510	COG1388	LysM domain
HCN55_RS10510	COG0791	NLP P60 protein
HCN55_RS10515	COG1819	glycosyl
HCN55_RS10520	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCN55_RS10525	COG0534	Mate efflux family protein
HCN55_RS10530	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS10535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCN55_RS10540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCN55_RS10550	COG2962	Rard protein
HCN55_RS10565	COG2610	gluconate transmembrane transporter activity
HCN55_RS10570	COG1942	4-Oxalocrotonate Tautomerase
HCN55_RS10575	COG1733	regulation of RNA biosynthetic process
HCN55_RS10580	COG0778	Nitroreductase
HCN55_RS10585	COG0400	carboxylic ester hydrolase activity
HCN55_RS10590	COG0346	lactoylglutathione lyase activity
HCN55_RS10600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN55_RS10605	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS10605	COG0793	Belongs to the peptidase S41A family
HCN55_RS10610	COG2226	methyltransferase
HCN55_RS10620	COG1876	peptidase activity
HCN55_RS10625	COG0813	purine-nucleoside phosphorylase activity
HCN55_RS10640	COG0671	phosphoesterase, PA-phosphatase related
HCN55_RS10660	COG4479	Belongs to the UPF0346 family
HCN55_RS10670	COG1509	lysine 2,3-aminomutase activity
HCN55_RS10675	COG0456	acetyltransferase
HCN55_RS10680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN55_RS10685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCN55_RS10690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCN55_RS10695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCN55_RS10710	COG0456	acetyltransferase
HCN55_RS10715	COG0463	Glycosyl transferase, family 2
HCN55_RS10730	COG4641	Protein conserved in bacteria
HCN55_RS10735	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HCN55_RS10740	COG1086	Polysaccharide biosynthesis protein
HCN55_RS10750	COG3331	DNA recombination
HCN55_RS10805	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCN55_RS10840	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HCN55_RS10845	COG0756	dUTP diphosphatase activity
HCN55_RS10850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS10870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN55_RS10870	COG1372	Participates in initiation and elongation during chromosome replication
HCN55_RS10875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCN55_RS10875	COG1372	Participates in initiation and elongation during chromosome replication
HCN55_RS10880	COG1780	Probably involved in ribonucleotide reductase function
HCN55_RS10970	COG0270	DNA (cytosine-5-)-methyltransferase activity
HCN55_RS10980	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HCN55_RS10985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HCN55_RS11010	COG3584	3D domain protein
HCN55_RS11015	COG0587	DNA-directed DNA polymerase activity
HCN55_RS11020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCN55_RS11025	COG0358	DNA primase activity
HCN55_RS11030	COG0305	Participates in initiation and elongation during chromosome replication
HCN55_RS11040	COG2887	Belongs to the helicase family. UvrD subfamily
HCN55_RS11070	COG5434	Belongs to the glycosyl hydrolase 28 family
HCN55_RS11070	COG3420	alginic acid biosynthetic process
HCN55_RS11075	COG4195	phage-related replication protein
HCN55_RS11090	COG2135	peptidase activity
HCN55_RS11095	COG1793	dna ligase
HCN55_RS11150	COG4474	Belongs to the UPF0398 family
HCN55_RS11160	COG1388	LysM domain
HCN55_RS11180	COG3645	SOS response
HCN55_RS11180	COG3646	Phage regulatory protein
HCN55_RS11235	COG3655	Transcriptional regulator
HCN55_RS11250	COG0582	viral genome integration into host DNA
HCN55_RS11330	COG3655	Transcriptional regulator
HCN55_RS11370	COG1395	domain, Protein
HCN55_RS11385	COG0776	regulation of translation
HCN55_RS11420	COG4373	Mu-like prophage FluMu protein gp28
HCN55_RS11520	COG0582	viral genome integration into host DNA
HCN55_RS11550	COG1196	nuclear chromosome segregation
HCN55_RS11550	COG0741	lytic transglycosylase activity
HCN55_RS11550	COG0739	heme binding
HCN55_RS11560	COG2433	Pfam Transposase IS66
HCN55_RS11570	COG4632	Exopolysaccharide biosynthesis protein
HCN55_RS11570	COG5434	Belongs to the glycosyl hydrolase 28 family
HCN55_RS11585	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS11600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HCN55_RS11605	COG0463	Glycosyl transferase, family 2
HCN55_RS11610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS11615	COG2274	protein secretion by the type I secretion system
HCN55_RS11615	COG3271	cysteine-type peptidase activity
HCN55_RS11630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN55_RS11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCN55_RS11675	COG5444	nuclease activity
HCN55_RS11680	COG4282	regulation of fungal-type cell wall biogenesis
HCN55_RS11695	COG1525	nuclease
HCN55_RS11705	COG2746	aminoglycoside 3-N-acetyltransferase activity
HCN55_RS11730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCN55_RS11735	COG1086	Polysaccharide biosynthesis protein
HCN55_RS11740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN55_RS11745	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCN55_RS11750	COG1846	Transcriptional regulator
HCN55_RS11755	COG0534	Mate efflux family protein
HCN55_RS11765	COG4698	Protein conserved in bacteria
HCN55_RS11770	COG2755	lipolytic protein G-D-S-L family
HCN55_RS11775	COG1999	signal sequence binding
HCN55_RS11785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCN55_RS11790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCN55_RS11795	COG1272	protein, Hemolysin III
HCN55_RS11800	COG0204	Acyl-transferase
HCN55_RS11805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCN55_RS11810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HCN55_RS11815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCN55_RS11825	COG2521	methyltransferase
HCN55_RS11825	COG2136	Putative SAM-dependent methyltransferase
HCN55_RS11835	COG0129	dihydroxy-acid dehydratase activity
HCN55_RS11840	COG1413	lyase activity
HCN55_RS11845	COG1418	mRNA catabolic process
HCN55_RS11850	COG0386	Belongs to the glutathione peroxidase family
HCN55_RS11855	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HCN55_RS11860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HCN55_RS11870	COG1278	Cold shock
HCN55_RS11890	COG0328	RNA-DNA hybrid ribonuclease activity
HCN55_RS11895	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HCN55_RS11900	COG0328	RNA-DNA hybrid ribonuclease activity
HCN55_RS11910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN55_RS11925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCN55_RS11935	COG1755	Isoprenylcysteine carboxyl methyltransferase
HCN55_RS11940	COG3424	synthase
HCN55_RS11945	COG2233	PERMEase
HCN55_RS11950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN55_RS11955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCN55_RS11965	COG0800	Aldolase
HCN55_RS11970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN55_RS11975	COG1609	Transcriptional regulator
HCN55_RS11980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HCN55_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS11990	COG1199	ATP-dependent helicase activity
HCN55_RS12005	COG0116	Belongs to the methyltransferase superfamily
HCN55_RS12020	COG4474	Belongs to the UPF0398 family
HCN55_RS12035	COG3359	exonuclease
HCN55_RS12040	COG1205	dead DEAH box helicase
HCN55_RS12040	COG1111	helicase
HCN55_RS12045	COG2190	(PTS) system
HCN55_RS12050	COG0071	Belongs to the small heat shock protein (HSP20) family
HCN55_RS12085	COG3331	DNA recombination
HCN55_RS12090	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCN55_RS12090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCN55_RS12100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCN55_RS12105	COG3935	DnaD domain protein
HCN55_RS12110	COG0017	Asparaginyl-tRNA synthetase
HCN55_RS12115	COG0436	Aminotransferase
HCN55_RS12120	COG5353	protein conserved in bacteria
HCN55_RS12130	COG1199	ATP-dependent helicase activity
HCN55_RS12130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCN55_RS12135	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HCN55_RS12140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HCN55_RS12145	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HCN55_RS12150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HCN55_RS12150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HCN55_RS12155	COG0617	tRNA 3'-terminal CCA addition
HCN55_RS12160	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS12165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCN55_RS12170	COG1803	Methylglyoxal synthase
HCN55_RS12175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HCN55_RS12180	COG1694	Mazg nucleotide pyrophosphohydrolase
HCN55_RS12185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS12195	COG4347	Protein of unknown function (DUF1405)
HCN55_RS12200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCN55_RS12200	COG2010	Cytochrome c
HCN55_RS12205	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCN55_RS12210	COG0723	plastoquinol--plastocyanin reductase activity
HCN55_RS12220	COG5582	Belongs to the UPF0302 family
HCN55_RS12225	COG0457	Tetratricopeptide repeat
HCN55_RS12230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HCN55_RS12235	COG0287	Prephenate dehydrogenase
HCN55_RS12240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HCN55_RS12245	COG0159	tryptophan synthase activity
HCN55_RS12250	COG0133	tryptophan synthase activity
HCN55_RS12255	COG0135	phosphoribosylanthranilate isomerase activity
HCN55_RS12265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCN55_RS12270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCN55_RS12275	COG4401	Chorismate mutase type I
HCN55_RS12280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HCN55_RS12285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HCN55_RS12290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCN55_RS12295	COG0105	UTP biosynthetic process
HCN55_RS12300	COG0142	geranyltranstransferase activity
HCN55_RS12305	COG2226	methyltransferase
HCN55_RS12310	COG0142	geranyltranstransferase activity
HCN55_RS12320	COG0302	gtp cyclohydrolase
HCN55_RS12325	COG0776	regulation of translation
HCN55_RS12330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCN55_RS12345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HCN55_RS12350	COG1160	GTP binding
HCN55_RS12375	COG1304	FMN binding
HCN55_RS12380	COG0539	negative regulation of cytoplasmic translation
HCN55_RS12385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HCN55_RS12395	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HCN55_RS12400	COG2959	enzyme of heme biosynthesis
HCN55_RS12405	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS12405	COG3773	Cell wall hydrolase
HCN55_RS12410	COG2339	peptidase activity
HCN55_RS12415	COG0492	ferredoxin-NADP+ reductase activity
HCN55_RS12420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN55_RS12425	COG4862	establishment of competence for transformation
HCN55_RS12430	COG1408	metallophosphoesterase
HCN55_RS12440	COG1388	LysM domain
HCN55_RS12445	COG1266	CAAX protease self-immunity
HCN55_RS12450	COG0514	ATP-dependent DNA helicase (RecQ)
HCN55_RS12455	COG4955	Helix-turn-helix domain
HCN55_RS12460	COG1141	Ferredoxin
HCN55_RS12465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HCN55_RS12470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCN55_RS12475	COG0710	3-dehydroquinate dehydratase activity
HCN55_RS12485	COG1595	DNA-templated transcription, initiation
HCN55_RS12490	COG5002	protein histidine kinase activity
HCN55_RS12495	COG0745	RESPONSE REGULATOR receiver
HCN55_RS12500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCN55_RS12505	COG1333	cytochrome c biogenesis protein
HCN55_RS12510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS12515	COG1187	pseudouridine synthase activity
HCN55_RS12520	COG0700	Nucleoside recognition
HCN55_RS12525	COG2715	membrane protein required for spore maturation
HCN55_RS12530	COG1686	Belongs to the peptidase S11 family
HCN55_RS12540	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HCN55_RS12545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HCN55_RS12550	COG1547	Domain of unknown function (DUF309)
HCN55_RS12555	COG0456	acetyltransferase
HCN55_RS12560	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HCN55_RS12565	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN55_RS12565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCN55_RS12570	COG0307	riboflavin synthase, alpha
HCN55_RS12575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN55_RS12575	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCN55_RS12585	COG0681	Belongs to the peptidase S26 family
HCN55_RS12595	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HCN55_RS12610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCN55_RS12615	COG4086	secreted protein
HCN55_RS12620	COG0019	diaminopimelate decarboxylase activity
HCN55_RS12625	COG0697	spore germination
HCN55_RS12640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCN55_RS12660	COG1191	sigma factor activity
HCN55_RS12665	COG2172	sigma factor antagonist activity
HCN55_RS12670	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS12675	COG1686	Belongs to the peptidase S11 family
HCN55_RS12680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HCN55_RS12685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HCN55_RS12690	COG4974	Belongs to the 'phage' integrase family
HCN55_RS12700	COG0735	belongs to the Fur family
HCN55_RS12705	COG1300	Membrane
HCN55_RS12715	COG0281	malic enzyme
HCN55_RS12720	COG1757	Na H antiporter
HCN55_RS12725	COG1027	Aspartate ammonia-lyase
HCN55_RS12730	COG0252	asparaginase activity
HCN55_RS12735	COG1396	sequence-specific DNA binding
HCN55_RS12740	COG1379	DNA repair
HCN55_RS12745	COG0494	nUDIX hydrolase
HCN55_RS12755	COG0667	Aldo Keto reductase
HCN55_RS12765	COG1073	alpha beta
HCN55_RS12775	COG4918	Iron-sulphur cluster biosynthesis
HCN55_RS12780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCN55_RS12780	COG0456	acetyltransferase
HCN55_RS12785	COG2329	Antibiotic biosynthesis monooxygenase
HCN55_RS12790	COG0456	acetyltransferase
HCN55_RS12800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN55_RS12810	COG2211	Major facilitator Superfamily
HCN55_RS12820	COG0346	lactoylglutathione lyase activity
HCN55_RS12825	COG1072	(Pantothenic acid kinase))
HCN55_RS12830	COG3048	D-serine ammonia-lyase activity
HCN55_RS12835	COG0300	oxidoreductase activity
HCN55_RS12840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS12845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN55_RS12850	COG4187	Peptidase family M20/M25/M40
HCN55_RS12855	COG1902	pentaerythritol trinitrate reductase activity
HCN55_RS12860	COG0596	Alpha beta hydrolase
HCN55_RS12870	COG1234	tRNA 3'-trailer cleavage
HCN55_RS12875	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCN55_RS12880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCN55_RS12885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HCN55_RS12895	COG0706	membrane insertase activity
HCN55_RS12900	COG3361	conserved protein (COG2071)
HCN55_RS12905	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN55_RS12910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCN55_RS12915	COG0346	lactoylglutathione lyase activity
HCN55_RS12925	COG1376	ErfK ybiS ycfS ynhG family protein
HCN55_RS12930	COG4129	membrane
HCN55_RS12935	COG1126	abc transporter atp-binding protein
HCN55_RS12940	COG0765	amino acid transport
HCN55_RS12945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS12955	COG1597	lipid kinase activity
HCN55_RS12960	COG2814	Major facilitator Superfamily
HCN55_RS12965	COG4978	Transcriptional regulator
HCN55_RS12965	COG0789	Transcriptional regulator
HCN55_RS12970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCN55_RS12975	COG0022	dehydrogenase e1 component
HCN55_RS12980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCN55_RS12985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCN55_RS12990	COG3426	butyrate kinase activity
HCN55_RS12995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN55_RS13000	COG0280	phosphate acetyltransferase
HCN55_RS13005	COG3290	protein histidine kinase activity
HCN55_RS13005	COG3829	transcription factor binding
HCN55_RS13015	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCN55_RS13020	COG2079	MmgE PrpD family protein
HCN55_RS13025	COG0372	Belongs to the citrate synthase family
HCN55_RS13030	COG1960	acyl-CoA dehydrogenase activity
HCN55_RS13035	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN55_RS13040	COG0183	Belongs to the thiolase family
HCN55_RS13045	COG0584	glycerophosphoryl diester phosphodiesterase
HCN55_RS13050	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS13065	COG1902	pentaerythritol trinitrate reductase activity
HCN55_RS13070	COG0745	RESPONSE REGULATOR receiver
HCN55_RS13075	COG0750	zinc metalloprotease
HCN55_RS13080	COG0497	DNA recombination
HCN55_RS13085	COG1438	arginine binding
HCN55_RS13090	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCN55_RS13095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HCN55_RS13100	COG0142	geranyltranstransferase activity
HCN55_RS13105	COG1722	exodeoxyribonuclease VII activity
HCN55_RS13110	COG1570	exodeoxyribonuclease VII activity
HCN55_RS13115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HCN55_RS13120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCN55_RS13125	COG1302	Protein conserved in bacteria
HCN55_RS13130	COG0439	Biotin carboxylase
HCN55_RS13135	COG0511	ligase activity, forming carbon-carbon bonds
HCN55_RS13175	COG3854	ATPases associated with a variety of cellular activities
HCN55_RS13185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HCN55_RS13190	COG0006	proline dipeptidase activity
HCN55_RS13195	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HCN55_RS13205	COG3872	metal-dependent enzyme
HCN55_RS13215	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCN55_RS13220	COG1321	iron dependent repressor
HCN55_RS13225	COG0095	Lipoate-protein ligase
HCN55_RS13230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN55_RS13235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN55_RS13240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HCN55_RS13245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HCN55_RS13250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCN55_RS13265	COG1396	sequence-specific DNA binding
HCN55_RS13275	COG0681	Belongs to the peptidase S26 family
HCN55_RS13300	COG4940	Competence protein ComGF
HCN55_RS13310	COG4970	Tfp pilus assembly protein FimT
HCN55_RS13315	COG4537	Required for transformation and DNA binding
HCN55_RS13320	COG1459	type II secretion system
HCN55_RS13325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCN55_RS13330	COG0598	Magnesium transport protein CorA
HCN55_RS13335	COG1253	flavin adenine dinucleotide binding
HCN55_RS13340	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS13350	COG1393	Belongs to the ArsC family
HCN55_RS13360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS13370	COG0011	TIGRFAM Protein of
HCN55_RS13380	COG2866	Carboxypeptidase
HCN55_RS13385	COG1368	sulfuric ester hydrolase activity
HCN55_RS13390	COG1940	carbohydrate kinase activity
HCN55_RS13395	COG4483	Protein conserved in bacteria
HCN55_RS13400	COG0457	Tetratricopeptide repeat
HCN55_RS13400	COG0705	Rhomboid family
HCN55_RS13410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCN55_RS13420	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS13435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCN55_RS13440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCN55_RS13445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HCN55_RS13450	COG0581	inorganic phosphate transmembrane transporter activity
HCN55_RS13455	COG0573	inorganic phosphate transmembrane transporter activity
HCN55_RS13460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCN55_RS13470	COG0477	Major facilitator Superfamily
HCN55_RS13475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCN55_RS13480	COG2839	Protein conserved in bacteria
HCN55_RS13485	COG5521	maltodextrose utilization protein MalA
HCN55_RS13495	COG1388	LysM domain
HCN55_RS13500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HCN55_RS13505	COG4709	membrane
HCN55_RS13510	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HCN55_RS13515	COG0735	belongs to the Fur family
HCN55_RS13520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS13530	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HCN55_RS13535	COG0513	Belongs to the DEAD box helicase family
HCN55_RS13545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HCN55_RS13550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCN55_RS13555	COG2384	SAM-dependent methyltransferase
HCN55_RS13560	COG2010	Cytochrome c
HCN55_RS13565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCN55_RS13570	COG0358	DNA primase activity
HCN55_RS13575	COG1671	Belongs to the UPF0178 family
HCN55_RS13580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HCN55_RS13585	COG0517	IMP dehydrogenase activity
HCN55_RS13590	COG0751	glycine-tRNA ligase activity
HCN55_RS13595	COG0752	glycyl-tRNA synthetase alpha subunit
HCN55_RS13600	COG1381	Involved in DNA repair and RecF pathway recombination
HCN55_RS13610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCN55_RS13615	COG0295	cytidine deaminase activity
HCN55_RS13620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCN55_RS13625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HCN55_RS13630	COG1480	7TM receptor with intracellular HD hydrolase
HCN55_RS13635	COG1702	phosphate starvation-inducible protein PhoH
HCN55_RS13640	COG0561	phosphatase activity
HCN55_RS13655	COG4864	UPF0365 protein
HCN55_RS13660	COG1030	water channel activity
HCN55_RS13665	COG1610	YqeY-like protein
HCN55_RS13675	COG1283	sodium-dependent phosphate transmembrane transporter activity
HCN55_RS13680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCN55_RS13685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCN55_RS13690	COG2264	protein methyltransferase activity
HCN55_RS13695	COG0484	heat shock protein binding
HCN55_RS13700	COG0443	Heat shock 70 kDa protein
HCN55_RS13705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HCN55_RS13710	COG1420	regulation of RNA biosynthetic process
HCN55_RS13715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCN55_RS13720	COG0481	GTPase activity
HCN55_RS13730	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS13735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HCN55_RS13740	COG0268	Binds directly to 16S ribosomal RNA
HCN55_RS13745	COG1466	dna polymerase III delta subunit
HCN55_RS13760	COG0658	competence protein
HCN55_RS13760	COG2333	competence protein COMEC
HCN55_RS13765	COG2131	deaminase
HCN55_RS13770	COG1555	photosystem II stabilization
HCN55_RS13770	COG1596	polysaccharide export
HCN55_RS13775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCN55_RS13780	COG2226	methyltransferase
HCN55_RS13785	COG0799	negative regulation of ribosome biogenesis
HCN55_RS13790	COG1713	HD superfamily hydrolase involved in NAD metabolism
HCN55_RS13795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HCN55_RS13800	COG1534	Rna-binding protein
HCN55_RS13805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HCN55_RS13810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCN55_RS13815	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCN55_RS13825	COG2755	lipolytic protein G-D-S-L family
HCN55_RS13830	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS13830	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS13835	COG0398	Pfam SNARE associated Golgi protein
HCN55_RS13840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HCN55_RS13850	COG3209	COG3209 Rhs family protein
HCN55_RS13860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCN55_RS13865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN55_RS13870	COG0798	PFAM Bile acid sodium symporter
HCN55_RS13875	COG0346	lactoylglutathione lyase activity
HCN55_RS13880	COG0640	Transcriptional regulator
HCN55_RS13885	COG3403	YqcI/YcgG family
HCN55_RS13890	COG0457	Tetratricopeptide repeat
HCN55_RS13905	COG5444	nuclease activity
HCN55_RS13930	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS13930	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS13935	COG4824	toxin secretion phage lysis holin
HCN55_RS13965	COG3778	Protein conserved in bacteria
HCN55_RS13970	COG3299	homolog of phage Mu protein gp47
HCN55_RS13975	COG3628	GPW Gp25 family protein
HCN55_RS13985	COG4193	domain, Protein
HCN55_RS13990	COG1652	LysM domain
HCN55_RS13995	COG3953	SLT domain
HCN55_RS13995	COG5280	Phage tail tape measure protein TP901
HCN55_RS14060	COG4653	Phage capsid family
HCN55_RS14065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HCN55_RS14075	COG2369	cell adhesion
HCN55_RS14080	COG5518	Phage portal protein
HCN55_RS14085	COG1783	phage Terminase large subunit
HCN55_RS14090	COG5484	DNA packaging
HCN55_RS14100	COG3677	Transposase
HCN55_RS14115	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HCN55_RS14125	COG1484	DNA-dependent DNA replication
HCN55_RS14130	COG3935	DnaD domain protein
HCN55_RS14135	COG3723	Recombinational DNA repair protein, rece pathway
HCN55_RS14140	COG5377	YqaJ viral recombinase family
HCN55_RS14170	COG1476	TRANSCRIPTIONal
HCN55_RS14175	COG3620	sequence-specific DNA binding
HCN55_RS14185	COG0563	adenylate kinase activity
HCN55_RS14190	COG2856	Zn peptidase
HCN55_RS14215	COG3223	Belongs to the PsiE family
HCN55_RS14220	COG0642	Histidine kinase
HCN55_RS14220	COG5002	protein histidine kinase activity
HCN55_RS14225	COG0745	RESPONSE REGULATOR receiver
HCN55_RS14230	COG2311	Membrane
HCN55_RS14240	COG0454	-acetyltransferase
HCN55_RS14245	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN55_RS14255	COG0730	response to heat
HCN55_RS14260	COG0425	Belongs to the sulfur carrier protein TusA family
HCN55_RS14265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS14265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN55_RS14275	COG0425	Belongs to the sulfur carrier protein TusA family
HCN55_RS14275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN55_RS14285	COG2210	Belongs to the sulfur carrier protein TusA family
HCN55_RS14290	COG1937	Protein conserved in bacteria
HCN55_RS14295	COG0662	Cupin 2, conserved barrel domain protein
HCN55_RS14305	COG4978	Transcriptional regulator
HCN55_RS14305	COG0789	Transcriptional regulator
HCN55_RS14310	COG2814	Major facilitator Superfamily
HCN55_RS14315	COG0456	acetyltransferase
HCN55_RS14320	COG1253	flavin adenine dinucleotide binding
HCN55_RS14330	COG0697	spore germination
HCN55_RS14335	COG0583	DNA-binding transcription factor activity
HCN55_RS14340	COG2072	flavoprotein involved in K transport
HCN55_RS14345	COG1230	cation diffusion facilitator family transporter
HCN55_RS14350	COG1942	4-Oxalocrotonate Tautomerase
HCN55_RS14355	COG0583	DNA-binding transcription factor activity
HCN55_RS14365	COG1114	Component of the transport system for branched-chain amino acids
HCN55_RS14370	COG1687	branched-chain amino acid
HCN55_RS14375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HCN55_RS14380	COG1522	sequence-specific DNA binding
HCN55_RS14385	COG2732	(Barnase) inhibitor
HCN55_RS14390	COG2124	cytochrome p450
HCN55_RS14400	COG1335	isochorismatase
HCN55_RS14415	COG2318	DinB family
HCN55_RS14425	COG2070	2-Nitropropane dioxygenase
HCN55_RS14430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCN55_RS14450	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCN55_RS14455	COG1595	DNA-templated transcription, initiation
HCN55_RS14460	COG0667	Aldo Keto reductase
HCN55_RS14465	COG2851	Citrate transporter
HCN55_RS14470	COG0583	DNA-binding transcription factor activity
HCN55_RS14475	COG2828	Protein conserved in bacteria
HCN55_RS14480	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS14485	COG5566	PFAM Mor transcription activator
HCN55_RS14490	COG0596	Alpha beta hydrolase
HCN55_RS14495	COG4991	sh3 domain protein
HCN55_RS14500	COG4991	sh3 domain protein
HCN55_RS14510	COG0346	lactoylglutathione lyase activity
HCN55_RS14520	COG5577	PFAM Coat F domain
HCN55_RS14525	COG1063	alcohol dehydrogenase
HCN55_RS14535	COG5577	PFAM Coat F domain
HCN55_RS14540	COG0789	Transcriptional regulator
HCN55_RS14550	COG1064	alcohol dehydrogenase
HCN55_RS14555	COG0693	protein deglycase activity
HCN55_RS14560	COG1621	beta-fructofuranosidase activity
HCN55_RS14565	COG3716	PTS system mannose fructose sorbose family IID component
HCN55_RS14570	COG3715	PTS system
HCN55_RS14575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS14580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS14585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCN55_RS14585	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCN55_RS14595	COG1113	amino acid transport
HCN55_RS14600	COG1280	lysine exporter protein (LysE YggA)
HCN55_RS14605	COG1378	Sugar-specific transcriptional regulator TrmB
HCN55_RS14610	COG1595	DNA-templated transcription, initiation
HCN55_RS14620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCN55_RS14620	COG2755	lipolytic protein G-D-S-L family
HCN55_RS14630	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCN55_RS14630	COG2124	cytochrome p450
HCN55_RS14635	COG1309	transcriptional regulator
HCN55_RS14640	COG2226	methyltransferase
HCN55_RS14655	COG2116	formate transmembrane transporter activity
HCN55_RS14660	COG5609	conserved protein (DUF2294)
HCN55_RS14665	COG3383	formate dehydrogenase (NAD+) activity
HCN55_RS14670	COG2427	Protein of unknown function (DUF1641)
HCN55_RS14680	COG0626	cystathionine gamma-synthase activity
HCN55_RS14685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN55_RS14690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCN55_RS14695	COG2226	methyltransferase
HCN55_RS14710	COG0768	penicillin binding
HCN55_RS14715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HCN55_RS14720	COG0572	uridine kinase
HCN55_RS14735	COG4122	O-methyltransferase activity
HCN55_RS14740	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCN55_RS14745	COG3906	Belongs to the UPF0473 family
HCN55_RS14750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HCN55_RS14755	COG4472	Bacterial protein of unknown function (DUF965)
HCN55_RS14760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCN55_RS14765	COG0628	permease
HCN55_RS14770	COG1126	abc transporter atp-binding protein
HCN55_RS14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS14780	COG0765	amino acid transport
HCN55_RS14785	COG0765	amino acid transport
HCN55_RS14800	COG3881	PFAM PRC-barrel domain
HCN55_RS14805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCN55_RS14810	COG0457	Tetratricopeptide repeat
HCN55_RS14815	COG0482	sulfurtransferase activity
HCN55_RS14820	COG1104	cysteine desulfurase activity
HCN55_RS14825	COG1959	2 iron, 2 sulfur cluster binding
HCN55_RS14830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCN55_RS14835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCN55_RS14845	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HCN55_RS14850	COG0124	histidyl-tRNA synthetase
HCN55_RS14860	COG4991	sh3 domain protein
HCN55_RS14860	COG3103	Sh3 type 3 domain protein
HCN55_RS14860	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS14865	COG1490	D-aminoacyl-tRNA deacylase activity
HCN55_RS14870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCN55_RS14875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCN55_RS14880	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCN55_RS14880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCN55_RS14885	COG5416	Lipopolysaccharide assembly protein A domain
HCN55_RS14890	COG0490	domain, Protein
HCN55_RS14895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN55_RS14895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCN55_RS14905	COG2244	polysaccharide biosynthetic process
HCN55_RS14910	COG2323	membrane
HCN55_RS14920	COG1862	Preprotein translocase
HCN55_RS14925	COG0343	queuine tRNA-ribosyltransferase activity
HCN55_RS14930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HCN55_RS14940	COG2255	four-way junction helicase activity
HCN55_RS14945	COG0632	four-way junction helicase activity
HCN55_RS14955	COG2814	Major facilitator Superfamily
HCN55_RS14960	COG0673	inositol 2-dehydrogenase activity
HCN55_RS14965	COG2112	serine threonine protein kinase
HCN55_RS14985	COG1115	amino acid carrier protein
HCN55_RS14990	COG0217	transcriptional regulatory protein
HCN55_RS15000	COG1388	LysM domain
HCN55_RS15005	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HCN55_RS15010	COG0157	Belongs to the NadC ModD family
HCN55_RS15015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCN55_RS15020	COG1104	cysteine desulfurase activity
HCN55_RS15025	COG1827	regulation of RNA biosynthetic process
HCN55_RS15030	COG0077	Prephenate dehydratase
HCN55_RS15035	COG4492	Belongs to the UPF0735 family
HCN55_RS15040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HCN55_RS15045	COG3290	protein histidine kinase activity
HCN55_RS15055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HCN55_RS15060	COG2868	ribosomal protein
HCN55_RS15065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HCN55_RS15070	COG1994	Peptidase M50
HCN55_RS15075	COG0739	heme binding
HCN55_RS15080	COG2894	cell division
HCN55_RS15085	COG0850	regulation of cytokinetic process
HCN55_RS15090	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HCN55_RS15100	COG1077	Cell shape determining protein MreB Mrl
HCN55_RS15105	COG2003	Belongs to the UPF0758 family
HCN55_RS15110	COG0424	maF-like protein
HCN55_RS15120	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCN55_RS15125	COG0285	dihydrofolate synthase activity
HCN55_RS15130	COG0525	valine-tRNA ligase activity
HCN55_RS15140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCN55_RS15145	COG1388	LysM domain
HCN55_RS15150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HCN55_RS15155	COG0113	porphobilinogen synthase activity
HCN55_RS15160	COG1587	Uroporphyrinogen-III synthase
HCN55_RS15165	COG0181	hydroxymethylbilane synthase activity
HCN55_RS15170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCN55_RS15175	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HCN55_RS15185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HCN55_RS15190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HCN55_RS15195	COG0470	DNA polymerase III
HCN55_RS15195	COG1067	ATP-dependent peptidase activity
HCN55_RS15200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HCN55_RS15205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCN55_RS15210	COG1477	protein flavinylation
HCN55_RS15210	COG0457	Tetratricopeptide repeat
HCN55_RS15215	COG0066	3-isopropylmalate dehydratase activity
HCN55_RS15220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HCN55_RS15225	COG0473	3-isopropylmalate dehydrogenase activity
HCN55_RS15230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCN55_RS15235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCN55_RS15240	COG0440	acetolactate synthase activity
HCN55_RS15245	COG0028	Belongs to the TPP enzyme family
HCN55_RS15255	COG0454	-acetyltransferase
HCN55_RS15260	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HCN55_RS15270	COG0622	Phosphoesterase
HCN55_RS15275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HCN55_RS15280	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HCN55_RS15285	COG5401	PFAM Sporulation and spore germination
HCN55_RS15290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCN55_RS15295	COG1846	Transcriptional regulator
HCN55_RS15300	COG2197	response regulator
HCN55_RS15305	COG0824	Thioesterase
HCN55_RS15310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCN55_RS15315	COG1053	succinate dehydrogenase
HCN55_RS15320	COG2009	succinate dehydrogenase
HCN55_RS15325	COG1719	4-vinyl reductase, 4VR
HCN55_RS15330	COG0527	aspartate kinase activity
HCN55_RS15335	COG0322	excinuclease ABC activity
HCN55_RS15340	COG3118	belongs to the thioredoxin family
HCN55_RS15345	COG3534	alpha-L-arabinofuranosidase
HCN55_RS15350	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCN55_RS15355	COG2086	electron transfer activity
HCN55_RS15360	COG1024	Enoyl-CoA hydratase
HCN55_RS15365	COG1309	transcriptional regulator
HCN55_RS15370	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS15375	COG3766	membrane
HCN55_RS15380	COG1193	negative regulation of DNA recombination
HCN55_RS15385	COG1796	DNA polymerase
HCN55_RS15385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCN55_RS15390	COG1286	toxin biosynthetic process
HCN55_RS15395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HCN55_RS15400	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HCN55_RS15405	COG0072	phenylalanine-tRNA ligase activity
HCN55_RS15405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN55_RS15410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HCN55_RS15420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCN55_RS15430	COG3835	regulator
HCN55_RS15435	COG0277	FAD linked oxidase domain protein
HCN55_RS15440	COG0247	lactate metabolic process
HCN55_RS15445	COG0346	lactoylglutathione lyase activity
HCN55_RS15455	COG1966	Carbon starvation protein
HCN55_RS15460	COG3534	alpha-L-arabinofuranosidase
HCN55_RS15465	COG0395	ABC-type sugar transport system, permease component
HCN55_RS15470	COG1175	transmembrane transport
HCN55_RS15475	COG1653	transport
HCN55_RS15480	COG0371	Dehydrogenase
HCN55_RS15485	COG0647	UMP catabolic process
HCN55_RS15490	COG0235	Class ii aldolase
HCN55_RS15495	COG1069	ribulokinase activity
HCN55_RS15500	COG2160	L-arabinose isomerase activity
HCN55_RS15505	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN55_RS15510	COG1363	Peptidase, m42
HCN55_RS15520	COG3326	Membrane
HCN55_RS15525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HCN55_RS15530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HCN55_RS15535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HCN55_RS15545	COG1346	cytolysis
HCN55_RS15550	COG1380	Effector of murein hydrolase LrgA
HCN55_RS15555	COG3279	Response regulator of the LytR AlgR family
HCN55_RS15560	COG3275	phosphorelay sensor kinase activity
HCN55_RS15565	COG1011	Hydrolase
HCN55_RS15570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCN55_RS15580	COG0398	Pfam SNARE associated Golgi protein
HCN55_RS15585	COG1484	DNA-dependent DNA replication
HCN55_RS15590	COG3611	Membrane attachment protein
HCN55_RS15595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HCN55_RS15600	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCN55_RS15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCN55_RS15610	COG1733	regulation of RNA biosynthetic process
HCN55_RS15615	COG2814	Major facilitator Superfamily
HCN55_RS15620	COG0656	L-ascorbic acid biosynthetic process
HCN55_RS15625	COG0237	dephospho-CoA kinase activity
HCN55_RS15630	COG1971	Probably functions as a manganese efflux pump
HCN55_RS15635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HCN55_RS15640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN55_RS15640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCN55_RS15645	COG5002	protein histidine kinase activity
HCN55_RS15650	COG0745	RESPONSE REGULATOR receiver
HCN55_RS15655	COG0039	L-malate dehydrogenase activity
HCN55_RS15660	COG0538	isocitrate dehydrogenase activity
HCN55_RS15665	COG0372	Belongs to the citrate synthase family
HCN55_RS15670	COG2707	UPF0756 membrane protein
HCN55_RS15675	COG0628	permease
HCN55_RS15680	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCN55_RS15685	COG0469	pyruvate kinase activity
HCN55_RS15690	COG0205	6-phosphofructokinase activity
HCN55_RS15695	COG0825	malonyl-CoA metabolic process
HCN55_RS15700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HCN55_RS15705	COG0281	malic enzyme
HCN55_RS15710	COG0587	DNA-directed DNA polymerase activity
HCN55_RS15730	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCN55_RS15740	COG4109	DRTGG domain
HCN55_RS15745	COG0730	response to heat
HCN55_RS15750	COG1473	amidohydrolase
HCN55_RS15755	COG0196	riboflavin kinase activity
HCN55_RS15760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS15765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HCN55_RS15770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS15775	COG1126	abc transporter atp-binding protein
HCN55_RS15780	COG0765	amino acid transport
HCN55_RS15785	COG0765	amino acid transport
HCN55_RS15790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS15795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS15800	COG0454	-acetyltransferase
HCN55_RS15805	COG0583	DNA-binding transcription factor activity
HCN55_RS15810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCN55_RS15815	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS15820	COG0165	Argininosuccinate lyase
HCN55_RS15825	COG0137	argininosuccinate synthase activity
HCN55_RS15830	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCN55_RS15835	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HCN55_RS15845	COG0827	DNA restriction-modification system
HCN55_RS15850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCN55_RS15855	COG3874	Sporulation protein YtfJ
HCN55_RS15865	COG1714	RDD family
HCN55_RS15870	COG0616	signal peptide processing
HCN55_RS15875	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HCN55_RS15880	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCN55_RS15885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCN55_RS15895	COG0301	tRNA thio-modification
HCN55_RS15900	COG1104	cysteine desulfurase activity
HCN55_RS15905	COG1114	Component of the transport system for branched-chain amino acids
HCN55_RS15910	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HCN55_RS15915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCN55_RS15920	COG1309	transcriptional regulator
HCN55_RS15925	COG1956	GAF domain-containing protein
HCN55_RS15930	COG2199	diguanylate cyclase activity
HCN55_RS15930	COG2203	Gaf domain
HCN55_RS15940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HCN55_RS15945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCN55_RS15950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCN55_RS15955	COG0454	-acetyltransferase
HCN55_RS15960	COG0517	IMP dehydrogenase activity
HCN55_RS15965	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCN55_RS15970	COG1360	Flagellar Motor Protein
HCN55_RS15975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCN55_RS15980	COG1609	Transcriptional regulator
HCN55_RS15985	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCN55_RS15985	COG1605	Chorismate mutase
HCN55_RS15990	COG3118	belongs to the thioredoxin family
HCN55_RS15995	COG4980	gas vesicle protein
HCN55_RS16000	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HCN55_RS16005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HCN55_RS16010	COG1674	ftsk spoiiie
HCN55_RS16015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCN55_RS16020	COG4848	Belongs to the UPF0354 family
HCN55_RS16025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS16040	COG1363	Peptidase, m42
HCN55_RS16045	COG5584	Small secreted protein
HCN55_RS16050	COG0281	malic enzyme
HCN55_RS16055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS16060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HCN55_RS16070	COG0510	thiamine kinase activity
HCN55_RS16075	COG1523	belongs to the glycosyl hydrolase 13 family
HCN55_RS16080	COG1597	lipid kinase activity
HCN55_RS16090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HCN55_RS16095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCN55_RS16100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN55_RS16105	COG2252	PERMEase
HCN55_RS16110	COG4473	ABC transporter
HCN55_RS16115	COG1131	(ABC) transporter
HCN55_RS16120	COG1349	DNA-binding transcription factor activity
HCN55_RS16125	COG1187	pseudouridine synthase activity
HCN55_RS16130	COG2244	polysaccharide biosynthetic process
HCN55_RS16135	COG2081	HI0933 family
HCN55_RS16140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCN55_RS16150	COG5578	integral membrane protein
HCN55_RS16155	COG0673	inositol 2-dehydrogenase activity
HCN55_RS16160	COG1653	transport
HCN55_RS16165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HCN55_RS16185	COG4209	transmembrane transport
HCN55_RS16190	COG2207	Transcriptional regulator
HCN55_RS16195	COG1653	transport
HCN55_RS16200	COG0395	ABC-type sugar transport system, permease component
HCN55_RS16205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN55_RS16210	COG2124	cytochrome p450
HCN55_RS16215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HCN55_RS16220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HCN55_RS16225	COG0156	8-amino-7-oxononanoate synthase activity
HCN55_RS16230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCN55_RS16235	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HCN55_RS16240	COG1073	alpha beta
HCN55_RS16245	COG1609	Transcriptional regulator
HCN55_RS16250	COG1653	transport
HCN55_RS16255	COG1175	transmembrane transport
HCN55_RS16260	COG0395	ABC-type sugar transport system, permease component
HCN55_RS16265	COG1486	melibiose metabolic process
HCN55_RS16270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCN55_RS16275	COG0495	leucyl-tRNA aminoacylation
HCN55_RS16285	COG1366	Belongs to the anti-sigma-factor antagonist family
HCN55_RS16285	COG2202	Pas domain
HCN55_RS16290	COG2814	Major facilitator Superfamily
HCN55_RS16295	COG2433	Pfam Transposase IS66
HCN55_RS16300	COG0577	efflux transmembrane transporter activity
HCN55_RS16305	COG1136	(ABC) transporter
HCN55_RS16310	COG2205	protein histidine kinase activity
HCN55_RS16315	COG0745	RESPONSE REGULATOR receiver
HCN55_RS16320	COG0577	efflux transmembrane transporter activity
HCN55_RS16325	COG1136	(ABC) transporter
HCN55_RS16340	COG1131	(ABC) transporter
HCN55_RS16345	COG1725	Transcriptional regulator
HCN55_RS16360	COG1242	4 iron, 4 sulfur cluster binding
HCN55_RS16365	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCN55_RS16375	COG2267	carboxylic ester hydrolase activity
HCN55_RS16380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCN55_RS16385	COG1113	amino acid transport
HCN55_RS16390	COG0367	asparagine synthase
HCN55_RS16400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HCN55_RS16410	COG1506	peptidase
HCN55_RS16415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCN55_RS16420	COG1116	anion transmembrane transporter activity
HCN55_RS16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCN55_RS16430	COG0494	nUDIX hydrolase
HCN55_RS16435	COG4824	toxin secretion phage lysis holin
HCN55_RS16440	COG0783	Belongs to the Dps family
HCN55_RS16455	COG1854	S-ribosylhomocysteine lyase activity
HCN55_RS16460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HCN55_RS16465	COG0288	reversible hydration of carbon dioxide
HCN55_RS16470	COG0254	rRNA binding
HCN55_RS16475	COG1271	oxidase subunit
HCN55_RS16480	COG1294	oxidase, subunit
HCN55_RS16490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN55_RS16495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCN55_RS16495	COG1321	iron dependent repressor
HCN55_RS16500	COG1121	(ABC) transporter
HCN55_RS16505	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCN55_RS16510	COG4948	Mandelate Racemase Muconate Lactonizing
HCN55_RS16515	COG0318	PFAM AMP-dependent synthetase and ligase
HCN55_RS16520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCN55_RS16525	COG0596	Alpha beta hydrolase
HCN55_RS16530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HCN55_RS16535	COG1169	isochorismate synthase
HCN55_RS16540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCN55_RS16545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCN55_RS16550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCN55_RS16555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCN55_RS16560	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS16570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCN55_RS16575	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS16580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCN55_RS16585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HCN55_RS16590	COG0058	SHG alpha-glucan phosphorylase activity
HCN55_RS16595	COG0297	glycogen (starch) synthase activity
HCN55_RS16600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCN55_RS16605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCN55_RS16610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HCN55_RS16735	COG3859	Proton-coupled thiamine transporter YuaJ
HCN55_RS16740	COG1247	-acetyltransferase
HCN55_RS16745	COG2268	Band 7 protein
HCN55_RS16750	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCN55_RS16755	COG2318	DinB family
HCN55_RS16765	COG1454	alcohol dehydrogenase
HCN55_RS16770	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS16775	COG1510	regulation of RNA biosynthetic process
HCN55_RS16785	COG0569	domain protein
HCN55_RS16790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCN55_RS16795	COG4682	membrane
HCN55_RS16800	COG1705	Flagellar rod assembly protein muramidase FlgJ
HCN55_RS16805	COG0477	Major facilitator Superfamily
HCN55_RS16810	COG5553	Cysteine dioxygenase type I
HCN55_RS16820	COG1968	undecaprenyl-diphosphatase activity
HCN55_RS16825	COG0628	permease
HCN55_RS16830	COG0673	inositol 2-dehydrogenase activity
HCN55_RS16835	COG4806	L-rhamnose isomerase
HCN55_RS16840	COG3254	rhamnose metabolic process
HCN55_RS16845	COG1070	Carbohydrate kinase
HCN55_RS16850	COG1349	DNA-binding transcription factor activity
HCN55_RS16855	COG3347	Dehydrogenase
HCN55_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS16860	COG0840	transmembrane signaling receptor activity
HCN55_RS16865	COG0840	transmembrane signaling receptor activity
HCN55_RS16870	COG0840	transmembrane signaling receptor activity
HCN55_RS16875	COG0840	transmembrane signaling receptor activity
HCN55_RS16890	COG0432	Pfam Uncharacterised protein family UPF0047
HCN55_RS16900	COG0366	Alpha amylase catalytic
HCN55_RS16905	COG1253	flavin adenine dinucleotide binding
HCN55_RS16910	COG2738	Putative neutral zinc metallopeptidase
HCN55_RS16925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCN55_RS16940	COG0166	Belongs to the GPI family
HCN55_RS16945	COG1979	alcohol dehydrogenase
HCN55_RS16950	COG1979	alcohol dehydrogenase
HCN55_RS16955	COG2155	Conserved Protein
HCN55_RS16960	COG1098	S1 RNA binding domain
HCN55_RS16965	COG0436	Aminotransferase
HCN55_RS16970	COG1522	sequence-specific DNA binding
HCN55_RS16975	COG2267	carboxylic ester hydrolase activity
HCN55_RS16985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCN55_RS16990	COG2205	protein histidine kinase activity
HCN55_RS17000	COG5018	Exonuclease
HCN55_RS17010	COG2814	Major facilitator Superfamily
HCN55_RS17015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCN55_RS17020	COG3011	Protein conserved in bacteria
HCN55_RS17030	COG3290	protein histidine kinase activity
HCN55_RS17035	COG4565	transcriptional regulatory protein
HCN55_RS17060	COG3493	citrate carrier protein
HCN55_RS17070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCN55_RS17070	COG2111	Na H antiporter
HCN55_RS17075	COG2111	Na H antiporter
HCN55_RS17080	COG1006	Multisubunit Na H antiporter MnhC subunit
HCN55_RS17085	COG0651	ATP synthesis coupled electron transport
HCN55_RS17090	COG1863	multisubunit Na H antiporter MnhE subunit
HCN55_RS17095	COG2212	antiporter activity
HCN55_RS17100	COG1320	monovalent cation:proton antiporter activity
HCN55_RS17105	COG2050	protein possibly involved in aromatic compounds catabolism
HCN55_RS17110	COG2197	response regulator
HCN55_RS17115	COG4585	Histidine kinase
HCN55_RS17125	COG0142	geranyltranstransferase activity
HCN55_RS17145	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HCN55_RS17150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCN55_RS17155	COG1335	isochorismatase
HCN55_RS17160	COG5506	Protein of unknown function (DUF1694)
HCN55_RS17175	COG0628	permease
HCN55_RS17190	COG1418	mRNA catabolic process
HCN55_RS17195	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS17205	COG1511	domain protein
HCN55_RS17210	COG1674	ftsk spoiiie
HCN55_RS17210	COG0433	COG0433 Predicted ATPase
HCN55_RS17215	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCN55_RS17220	COG5417	Belongs to the EsaB family
HCN55_RS17225	COG4842	Belongs to the WXG100 family
HCN55_RS17230	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HCN55_RS17230	COG2508	Transcriptional regulator
HCN55_RS17235	COG0686	Belongs to the AlaDH PNT family
HCN55_RS17240	COG5634	Uncharacterized conserved protein (DUF2278)
HCN55_RS17245	COG3251	PFAM MbtH domain protein
HCN55_RS17250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS17255	COG3433	isochorismatase activity
HCN55_RS17255	COG1535	isochorismatase
HCN55_RS17260	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCN55_RS17265	COG1169	isochorismate synthase
HCN55_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS17275	COG2819	hydrolase of the alpha beta superfamily
HCN55_RS17280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCN55_RS17285	COG1268	BioY protein
HCN55_RS17290	COG2056	Na+-H+ antiporter family
HCN55_RS17295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HCN55_RS17300	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCN55_RS17305	COG3584	3D domain protein
HCN55_RS17320	COG1252	NADH dehydrogenase
HCN55_RS17325	COG0492	ferredoxin-NADP+ reductase activity
HCN55_RS17335	COG0516	GMP reductase activity
HCN55_RS17340	COG2808	Putative FMN-binding domain
HCN55_RS17345	COG0456	acetyltransferase
HCN55_RS17350	COG0316	Belongs to the HesB IscA family
HCN55_RS17355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HCN55_RS17360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCN55_RS17365	COG4844	belongs to the
HCN55_RS17370	COG1252	NADH dehydrogenase
HCN55_RS17375	COG4837	Protein of unknown function (DUF1462)
HCN55_RS17380	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCN55_RS17385	COG4946	Tricorn protease homolog
HCN55_RS17385	COG0823	Involved in the tonB-independent uptake of proteins
HCN55_RS17385	COG1506	peptidase
HCN55_RS17390	COG0083	homoserine kinase activity
HCN55_RS17395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HCN55_RS17400	COG0460	homoserine dehydrogenase
HCN55_RS17405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCN55_RS17410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCN55_RS17415	COG0647	UMP catabolic process
HCN55_RS17420	COG2445	Protein of unknown function DUF86
HCN55_RS17425	COG4470	Protein conserved in bacteria
HCN55_RS17435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HCN55_RS17440	COG0739	heme binding
HCN55_RS17450	COG3377	Domain of unknown function (DUF1805)
HCN55_RS17455	COG0737	Belongs to the 5'-nucleotidase family
HCN55_RS17460	COG0730	response to heat
HCN55_RS17465	COG1801	Protein of unknown function DUF72
HCN55_RS17480	COG2508	Transcriptional regulator
HCN55_RS17485	COG2233	PERMEase
HCN55_RS17490	COG2233	PERMEase
HCN55_RS17495	COG3648	Uricase
HCN55_RS17495	COG3195	allantoin biosynthetic process
HCN55_RS17500	COG2351	hydroxyisourate hydrolase activity
HCN55_RS17510	COG2080	2 iron, 2 sulfur cluster binding
HCN55_RS17515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HCN55_RS17520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HCN55_RS17525	COG2068	MobA-Related Protein
HCN55_RS17530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HCN55_RS17535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HCN55_RS17540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCN55_RS17550	COG2356	endonuclease I
HCN55_RS17555	COG3842	ATPase activity
HCN55_RS17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN55_RS17570	COG0395	ABC-type sugar transport system, permease component
HCN55_RS17575	COG1175	transmembrane transport
HCN55_RS17580	COG1653	transport
HCN55_RS17585	COG2222	sugar isomerase
HCN55_RS17590	COG0322	excinuclease ABC activity
HCN55_RS17595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCN55_RS17610	COG0346	lactoylglutathione lyase activity
HCN55_RS17615	COG0640	Transcriptional regulator
HCN55_RS17620	COG0719	Fe-S assembly protein
HCN55_RS17625	COG0822	iron-sulfur transferase activity
HCN55_RS17630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCN55_RS17635	COG0719	Fe-S assembly protein
HCN55_RS17640	COG0396	ATPase activity
HCN55_RS17650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCN55_RS17655	COG1464	Belongs to the NlpA lipoprotein family
HCN55_RS17660	COG2011	ABC-type metal ion transport system permease component
HCN55_RS17665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCN55_RS17675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCN55_RS17680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCN55_RS17690	COG0509	glycine decarboxylation via glycine cleavage system
HCN55_RS17695	COG1393	Belongs to the ArsC family
HCN55_RS17700	COG1960	acyl-CoA dehydrogenase activity
HCN55_RS17705	COG0183	Belongs to the thiolase family
HCN55_RS17710	COG1024	Enoyl-CoA hydratase
HCN55_RS17710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCN55_RS17720	COG0506	proline dehydrogenase activity
HCN55_RS17730	COG5577	PFAM Coat F domain
HCN55_RS17735	COG1846	Transcriptional regulator
HCN55_RS17740	COG0477	Major facilitator Superfamily
HCN55_RS17745	COG1942	4-Oxalocrotonate Tautomerase
HCN55_RS17755	COG0583	DNA-binding transcription factor activity
HCN55_RS17765	COG1120	ATPase activity
HCN55_RS17780	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS17785	COG0783	Belongs to the Dps family
HCN55_RS17790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN55_RS17795	COG0745	RESPONSE REGULATOR receiver
HCN55_RS17800	COG2205	protein histidine kinase activity
HCN55_RS17800	COG2770	Histidine kinase
HCN55_RS17810	COG1309	transcriptional regulator
HCN55_RS17815	COG0114	fumarate hydratase activity
HCN55_RS17825	COG0697	spore germination
HCN55_RS17830	COG0814	amino acid
HCN55_RS17840	COG2197	response regulator
HCN55_RS17845	COG4585	Histidine kinase
HCN55_RS17850	COG4758	membrane
HCN55_RS17855	COG3595	metallopeptidase activity
HCN55_RS17860	COG1842	Phage shock protein A
HCN55_RS17865	COG4758	membrane
HCN55_RS17870	COG2814	Major facilitator Superfamily
HCN55_RS17875	COG2096	Adenosyltransferase
HCN55_RS17880	COG1120	ATPase activity
HCN55_RS17885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS17890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS17900	COG3386	PFAM SMP-30 Gluconolaconase
HCN55_RS17905	COG2205	protein histidine kinase activity
HCN55_RS17910	COG0745	RESPONSE REGULATOR receiver
HCN55_RS17920	COG1191	sigma factor activity
HCN55_RS17930	COG2140	Oxalate decarboxylase
HCN55_RS17940	COG0577	efflux transmembrane transporter activity
HCN55_RS17945	COG1136	(ABC) transporter
HCN55_RS17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HCN55_RS17955	COG1120	ATPase activity
HCN55_RS17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCN55_RS17970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS17975	COG0531	amino acid
HCN55_RS17985	COG1988	membrane-bound metal-dependent
HCN55_RS17990	COG1368	sulfuric ester hydrolase activity
HCN55_RS17995	COG1910	domain protein
HCN55_RS18000	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCN55_RS18005	COG4149	molybdate abc transporter
HCN55_RS18010	COG0656	L-ascorbic acid biosynthetic process
HCN55_RS18020	COG0025	NhaP-type Na H and K H
HCN55_RS18025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCN55_RS18030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HCN55_RS18035	COG3973	AAA domain
HCN55_RS18040	COG2860	membrane
HCN55_RS18045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HCN55_RS18050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCN55_RS18055	COG2217	Heavy metal translocating P-type atpase
HCN55_RS18060	COG2217	Heavy metal translocating P-type atpase
HCN55_RS18065	COG2608	mercury ion transmembrane transporter activity
HCN55_RS18070	COG1937	Protein conserved in bacteria
HCN55_RS18075	COG0673	inositol 2-dehydrogenase activity
HCN55_RS18080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HCN55_RS18085	COG1289	transmembrane transporter activity
HCN55_RS18095	COG2076	Multidrug Resistance protein
HCN55_RS18100	COG1309	transcriptional regulator
HCN55_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS18115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HCN55_RS18120	COG0557	exoribonuclease II activity
HCN55_RS18125	COG1647	Serine aminopeptidase, S33
HCN55_RS18130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCN55_RS18135	COG0596	Alpha beta hydrolase
HCN55_RS18140	COG1476	TRANSCRIPTIONal
HCN55_RS18145	COG1396	sequence-specific DNA binding
HCN55_RS18150	COG1396	sequence-specific DNA binding
HCN55_RS18155	COG1733	regulation of RNA biosynthetic process
HCN55_RS18160	COG0840	transmembrane signaling receptor activity
HCN55_RS18165	COG1174	glycine betaine transport
HCN55_RS18170	COG1732	Glycine betaine
HCN55_RS18175	COG1174	glycine betaine transport
HCN55_RS18180	COG0517	IMP dehydrogenase activity
HCN55_RS18180	COG1125	glycine betaine transport
HCN55_RS18185	COG1510	regulation of RNA biosynthetic process
HCN55_RS18205	COG5658	integral membrane protein
HCN55_RS18210	COG0640	Transcriptional regulator
HCN55_RS18215	COG1174	glycine betaine transport
HCN55_RS18220	COG1732	Glycine betaine
HCN55_RS18225	COG1174	glycine betaine transport
HCN55_RS18230	COG1125	glycine betaine transport
HCN55_RS18230	COG0517	IMP dehydrogenase activity
HCN55_RS18235	COG1510	regulation of RNA biosynthetic process
HCN55_RS18240	COG2095	MarC family integral membrane protein
HCN55_RS18250	COG3064	Membrane
HCN55_RS18255	COG4640	response to antibiotic
HCN55_RS18260	COG0456	acetyltransferase
HCN55_RS18265	COG0148	phosphopyruvate hydratase activity
HCN55_RS18270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HCN55_RS18275	COG0149	triose-phosphate isomerase activity
HCN55_RS18280	COG0126	phosphoglycerate kinase activity
HCN55_RS18285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCN55_RS18290	COG2390	Transcriptional regulator
HCN55_RS18295	COG2814	Major facilitator Superfamily
HCN55_RS18300	COG1609	Transcriptional regulator
HCN55_RS18305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS18310	COG0583	DNA-binding transcription factor activity
HCN55_RS18315	COG0697	spore germination
HCN55_RS18320	COG1113	amino acid transport
HCN55_RS18325	COG3858	chitin binding
HCN55_RS18330	COG1556	Lactate utilization protein
HCN55_RS18335	COG1139	Iron-sulfur cluster binding protein
HCN55_RS18340	COG0247	lactate metabolic process
HCN55_RS18345	COG2197	response regulator
HCN55_RS18350	COG4585	Histidine kinase
HCN55_RS18355	COG0842	Transport permease protein
HCN55_RS18360	COG1131	(ABC) transporter
HCN55_RS18365	COG0596	Alpha beta hydrolase
HCN55_RS18370	COG2208	phosphoserine phosphatase activity
HCN55_RS18375	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HCN55_RS18380	COG1874	Beta-galactosidase
HCN55_RS18385	COG3833	ABC-type maltose transport systems, permease component
HCN55_RS18390	COG1175	transmembrane transport
HCN55_RS18395	COG2182	Extracellular solute-binding protein
HCN55_RS18400	COG1609	Transcriptional regulator
HCN55_RS18405	COG2186	Transcriptional regulator
HCN55_RS18410	COG1620	l-lactate permease
HCN55_RS18415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCN55_RS18425	COG5039	Polysaccharide pyruvyl transferase
HCN55_RS18430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN55_RS18435	COG0110	maltose O-acetyltransferase activity
HCN55_RS18440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCN55_RS18445	COG2244	polysaccharide biosynthetic process
HCN55_RS18450	COG1216	Glycosyl transferase, family 2
HCN55_RS18455	COG5039	Polysaccharide pyruvyl transferase
HCN55_RS18460	COG1216	Glycosyl transferase, family 2
HCN55_RS18470	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS18475	COG1215	transferase activity, transferring glycosyl groups
HCN55_RS18480	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS18485	COG1086	Polysaccharide biosynthesis protein
HCN55_RS18490	COG0489	protein tyrosine kinase activity
HCN55_RS18495	COG3944	biosynthesis protein
HCN55_RS18500	COG1396	sequence-specific DNA binding
HCN55_RS18505	COG2272	Belongs to the type-B carboxylesterase lipase family
HCN55_RS18515	COG3479	Phenolic acid decarboxylase
HCN55_RS18525	COG1794	racemase activity, acting on amino acids and derivatives
HCN55_RS18530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCN55_RS18535	COG1621	beta-fructofuranosidase activity
HCN55_RS18540	COG1621	beta-fructofuranosidase activity
HCN55_RS18545	COG0531	amino acid
HCN55_RS18550	COG1309	transcriptional regulator
HCN55_RS18555	COG2076	Multidrug Resistance protein
HCN55_RS18560	COG2076	Multidrug Resistance protein
HCN55_RS18570	COG0277	FAD linked oxidase domain protein
HCN55_RS18575	COG3621	Patatin-like phospholipase
HCN55_RS18585	COG0740	serine-type endopeptidase activity
HCN55_RS18590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCN55_RS18595	COG0366	Alpha amylase catalytic
HCN55_RS18600	COG1554	hydrolase, family 65, central catalytic
HCN55_RS18605	COG5521	maltodextrose utilization protein MalA
HCN55_RS18610	COG3833	ABC-type maltose transport systems, permease component
HCN55_RS18615	COG1175	transmembrane transport
HCN55_RS18620	COG2182	Extracellular solute-binding protein
HCN55_RS18625	COG0366	Alpha amylase catalytic
HCN55_RS18630	COG1609	Transcriptional regulator
HCN55_RS18635	COG1611	Belongs to the LOG family
HCN55_RS18640	COG1694	Mazg nucleotide pyrophosphohydrolase
HCN55_RS18645	COG0659	secondary active sulfate transmembrane transporter activity
HCN55_RS18650	COG0288	reversible hydration of carbon dioxide
HCN55_RS18655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCN55_RS18660	COG0577	efflux transmembrane transporter activity
HCN55_RS18665	COG1136	(ABC) transporter
HCN55_RS18670	COG5002	protein histidine kinase activity
HCN55_RS18675	COG0745	RESPONSE REGULATOR receiver
HCN55_RS18685	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCN55_RS18690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS18695	COG1481	regulation of sporulation
HCN55_RS18700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCN55_RS18705	COG1660	Displays ATPase and GTPase activities
HCN55_RS18710	COG1051	belongs to the nudix hydrolase family
HCN55_RS18715	COG0492	ferredoxin-NADP+ reductase activity
HCN55_RS18720	COG3883	PFAM NLP P60 protein
HCN55_RS18720	COG0791	NLP P60 protein
HCN55_RS18725	COG0457	Tetratricopeptide repeat
HCN55_RS18730	COG1132	(ABC) transporter
HCN55_RS18750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HCN55_RS18750	COG0140	phosphoribosyl-ATP diphosphatase activity
HCN55_RS18755	COG0107	imidazoleglycerol-phosphate synthase activity
HCN55_RS18760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HCN55_RS18765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HCN55_RS18770	COG0131	Imidazoleglycerol-phosphate dehydratase
HCN55_RS18775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HCN55_RS18780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HCN55_RS18785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HCN55_RS18790	COG4990	cell redox homeostasis
HCN55_RS18795	COG5297	Belongs to the glycosyl hydrolase family 6
HCN55_RS18800	COG0110	maltose O-acetyltransferase activity
HCN55_RS18805	COG0546	phosphoglycolate phosphatase activity
HCN55_RS18810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCN55_RS18815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HCN55_RS18820	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HCN55_RS18825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCN55_RS18830	COG0363	glucosamine-6-phosphate deaminase activity
HCN55_RS18835	COG2188	Transcriptional regulator
HCN55_RS18840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCN55_RS18845	COG1846	Transcriptional regulator
HCN55_RS18850	COG2124	cytochrome p450
HCN55_RS18860	COG1846	Transcriptional regulator
HCN55_RS18865	COG2814	Major facilitator Superfamily
HCN55_RS18870	COG1950	PFAM Membrane protein of
HCN55_RS18875	COG1983	PspC domain protein
HCN55_RS18880	COG3595	metallopeptidase activity
HCN55_RS18900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCN55_RS18905	COG0556	nucleotide-excision repair
HCN55_RS18910	COG4897	Protein conserved in bacteria
HCN55_RS18915	COG0574	Belongs to the PEP-utilizing enzyme family
HCN55_RS18915	COG3848	Pyruvate phosphate dikinase
HCN55_RS18920	COG1309	transcriptional regulator
HCN55_RS18925	COG2814	Major facilitator Superfamily
HCN55_RS18930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN55_RS18940	COG3409	Peptidoglycan-binding domain 1 protein
HCN55_RS18940	COG0793	Belongs to the peptidase S41A family
HCN55_RS18945	COG2177	Part of the ABC transporter FtsEX involved in
HCN55_RS18950	COG2884	Cell division ATP-binding protein ftsE
HCN55_RS18955	COG2010	Cytochrome c
HCN55_RS18960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS18970	COG0653	protein targeting
HCN55_RS18975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCN55_RS18990	COG1516	flagellar protein fliS
HCN55_RS18995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCN55_RS19000	COG1334	flagellar protein FlaG
HCN55_RS19005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCN55_RS19010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HCN55_RS19015	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HCN55_RS19030	COG1256	bacterial-type flagellum assembly
HCN55_RS19030	COG4786	Flagellar basal body rod
HCN55_RS19035	COG3418	PFAM FlgN family protein
HCN55_RS19040	COG2747	anti-sigma28 factor FlgM
HCN55_RS19050	COG1040	competence protein
HCN55_RS19060	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HCN55_RS19065	COG1307	EDD domain protein, DegV family
HCN55_RS19070	COG2197	response regulator
HCN55_RS19075	COG4585	Histidine kinase
HCN55_RS19080	COG1739	Uncharacterized protein family UPF0029
HCN55_RS19085	COG1316	TRANSCRIPTIONal
HCN55_RS19090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCN55_RS19095	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS19100	COG1215	transferase activity, transferring glycosyl groups
HCN55_RS19105	COG3206	protein involved in exopolysaccharide biosynthesis
HCN55_RS19110	COG3307	-O-antigen
HCN55_RS19115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCN55_RS19120	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS19120	COG0297	glycogen (starch) synthase activity
HCN55_RS19125	COG2244	polysaccharide biosynthetic process
HCN55_RS19135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCN55_RS19135	COG2247	cell wall binding repeat
HCN55_RS19140	COG2385	sporulation resulting in formation of a cellular spore
HCN55_RS19140	COG2247	cell wall binding repeat
HCN55_RS19150	COG1316	TRANSCRIPTIONal
HCN55_RS19155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCN55_RS19160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCN55_RS19175	COG0463	Glycosyl transferase, family 2
HCN55_RS19185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCN55_RS19195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCN55_RS19200	COG1134	teichoic acid transport
HCN55_RS19205	COG1682	transport, permease protein
HCN55_RS19210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCN55_RS19215	COG0438	transferase activity, transferring glycosyl groups
HCN55_RS19220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HCN55_RS19225	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HCN55_RS19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCN55_RS19240	COG4193	domain, Protein
HCN55_RS19245	COG1482	cell wall glycoprotein biosynthetic process
HCN55_RS19250	COG0697	spore germination
HCN55_RS19255	COG0814	amino acid
HCN55_RS19265	COG2814	Major facilitator Superfamily
HCN55_RS19270	COG1316	TRANSCRIPTIONal
HCN55_RS19275	COG0561	phosphatase activity
HCN55_RS19280	COG0791	NLP P60 protein
HCN55_RS19290	COG2843	Capsule synthesis protein
HCN55_RS19300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HCN55_RS19305	COG1609	Transcriptional regulator
HCN55_RS19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN55_RS19315	COG1869	D-ribose catabolic process
HCN55_RS19320	COG1129	ABC transporter
HCN55_RS19325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCN55_RS19330	COG1879	ABC-type sugar transport system periplasmic component
HCN55_RS19335	COG3103	Sh3 type 3 domain protein
HCN55_RS19345	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCN55_RS19350	COG3527	Alpha-acetolactate decarboxylase
HCN55_RS19355	COG0028	Belongs to the TPP enzyme family
HCN55_RS19360	COG0583	DNA-binding transcription factor activity
HCN55_RS19365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCN55_RS19380	COG5337	Spore coat protein CotH
HCN55_RS19390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCN55_RS19400	COG0405	Gamma-glutamyltransferase
HCN55_RS19405	COG1522	sequence-specific DNA binding
HCN55_RS19410	COG2059	Chromate
HCN55_RS19415	COG2059	Chromate
HCN55_RS19425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCN55_RS19430	COG0583	DNA-binding transcription factor activity
HCN55_RS19435	COG1515	deoxyribonuclease V activity
HCN55_RS19440	COG2849	repeat protein
HCN55_RS19445	COG5444	nuclease activity
HCN55_RS19465	COG3878	Protein conserved in bacteria
HCN55_RS19470	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCN55_RS19475	COG4464	protein tyrosine phosphatase activity
HCN55_RS19480	COG0489	protein tyrosine kinase activity
HCN55_RS19485	COG3944	biosynthesis protein
HCN55_RS19495	COG4715	Zinc finger, swim domain protein
HCN55_RS19500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCN55_RS19505	COG0561	phosphatase activity
HCN55_RS19510	COG1349	DNA-binding transcription factor activity
HCN55_RS19515	COG0629	single-stranded DNA binding
HCN55_RS19540	COG2972	Histidine kinase
HCN55_RS19540	COG0745	RESPONSE REGULATOR receiver
HCN55_RS19545	COG1970	mechanosensitive ion channel activity
HCN55_RS19550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCN55_RS19555	COG0457	Tetratricopeptide repeat
HCN55_RS19560	COG4786	Flagellar basal body rod
HCN55_RS19565	COG4786	Flagellar basal body rod
HCN55_RS19570	COG1077	Cell shape determining protein MreB Mrl
HCN55_RS19575	COG1609	Transcriptional regulator
HCN55_RS19585	COG1846	Transcriptional regulator
HCN55_RS19590	COG2814	Major facilitator Superfamily
HCN55_RS19595	COG3420	alginic acid biosynthetic process
HCN55_RS19600	COG1953	Uracil, thiamine, allantoin
HCN55_RS19605	COG0477	Major facilitator Superfamily
HCN55_RS19610	COG1335	isochorismatase
HCN55_RS19620	COG0004	ammonium transporteR
HCN55_RS19625	COG0347	Belongs to the P(II) protein family
HCN55_RS19630	COG0671	phosphoesterase, PA-phosphatase related
HCN55_RS19640	COG0739	heme binding
HCN55_RS19645	COG1247	-acetyltransferase
HCN55_RS19665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCN55_RS19670	COG0789	Transcriptional regulator
HCN55_RS19680	COG2910	NAD(P)H-binding
HCN55_RS19685	COG1959	2 iron, 2 sulfur cluster binding
HCN55_RS19690	COG0804	urea catabolic process
HCN55_RS19695	COG0832	Belongs to the urease beta subunit family
HCN55_RS19700	COG0831	urea catabolic process
HCN55_RS19715	COG3237	CsbD-like
HCN55_RS19720	COG1994	Peptidase M50
HCN55_RS19725	COG0457	Tetratricopeptide repeat
HCN55_RS19730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCN55_RS19735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCN55_RS19745	COG2304	oxidoreductase activity
HCN55_RS19755	COG2304	oxidoreductase activity
HCN55_RS19760	COG2385	sporulation resulting in formation of a cellular spore
HCN55_RS19765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCN55_RS19775	COG4836	Membrane
HCN55_RS19785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HCN55_RS19790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HCN55_RS19795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HCN55_RS19800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HCN55_RS19805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HCN55_RS19810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HCN55_RS19820	COG0356	it plays a direct role in the translocation of protons across the membrane
HCN55_RS19830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HCN55_RS19835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HCN55_RS19840	COG4475	Protein of unknown function (DUF436)
HCN55_RS19845	COG0698	ribose 5-phosphate isomerase
HCN55_RS19850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCN55_RS19855	COG1971	Probably functions as a manganese efflux pump
HCN55_RS19860	COG0009	L-threonylcarbamoyladenylate synthase
HCN55_RS19865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HCN55_RS19885	COG2890	protein-(glutamine-N5) methyltransferase activity
HCN55_RS19890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HCN55_RS19895	COG0346	lactoylglutathione lyase activity
HCN55_RS19900	COG0789	Transcriptional regulator
HCN55_RS19905	COG0679	Auxin Efflux Carrier
HCN55_RS19910	COG0281	malic enzyme
HCN55_RS19915	COG1435	thymidine kinase activity
HCN55_RS19925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCN55_RS19935	COG1494	fructose-1,6-bisphosphatase
HCN55_RS19940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HCN55_RS19945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCN55_RS19950	COG0191	fructose-bisphosphate aldolase activity
HCN55_RS19955	COG2204	response regulator
HCN55_RS19960	COG4821	SIS domain
HCN55_RS19965	COG0504	CTP synthase activity
HCN55_RS19970	COG3343	RNA polymerase activity
HCN55_RS19975	COG1960	acyl-CoA dehydrogenase activity
HCN55_RS19980	COG0247	lactate metabolic process
HCN55_RS19980	COG2181	nitrate reductase activity
HCN55_RS19985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCN55_RS19990	COG4294	response to UV
HCN55_RS20000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCN55_RS20005	COG1132	(ABC) transporter
HCN55_RS20010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCN55_RS20020	COG2181	nitrate reductase activity
HCN55_RS20025	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCN55_RS20030	COG1140	nitrate reductase beta subunit
HCN55_RS20035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCN55_RS20040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCN55_RS20050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCN55_RS20055	COG2223	nitrite transmembrane transporter activity
HCN55_RS20060	COG0018	arginyl-trna synthetase
HCN55_RS20065	COG4506	Protein conserved in bacteria
HCN55_RS20080	COG0535	radical SAM domain protein
HCN55_RS20090	COG1131	(ABC) transporter
HCN55_RS20095	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCN55_RS20100	COG0612	Peptidase, M16
HCN55_RS20105	COG0612	Peptidase, M16
HCN55_RS20115	COG3391	amine dehydrogenase activity
HCN55_RS20120	COG3391	amine dehydrogenase activity
HCN55_RS20130	COG0457	Tetratricopeptide repeat
HCN55_RS20140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCN55_RS20145	COG0010	Belongs to the arginase family
HCN55_RS20150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HCN55_RS20155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCN55_RS20165	COG1994	Peptidase M50
HCN55_RS20170	COG1942	4-Oxalocrotonate Tautomerase
HCN55_RS20175	COG1846	Transcriptional regulator
HCN55_RS20180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCN55_RS20185	COG0477	Major facilitator Superfamily
HCN55_RS20190	COG1959	2 iron, 2 sulfur cluster binding
HCN55_RS20195	COG3465	dGTPase activity
HCN55_RS20200	COG1078	dGTPase activity
HCN55_RS20205	COG4844	belongs to the
HCN55_RS20215	COG0697	spore germination
HCN55_RS20220	COG0095	Lipoate-protein ligase
HCN55_RS20225	COG0583	DNA-binding transcription factor activity
HCN55_RS20230	COG0280	phosphate acetyltransferase
HCN55_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS20245	COG0436	Aminotransferase
HCN55_RS20250	COG2814	Major facilitator Superfamily
HCN55_RS20255	COG0151	Belongs to the GarS family
HCN55_RS20260	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS20265	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS20270	COG0077	Prephenate dehydratase
HCN55_RS20275	COG2814	Major facilitator Superfamily
HCN55_RS20280	COG0833	amino acid
HCN55_RS20285	COG4187	Peptidase family M20/M25/M40
HCN55_RS20290	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS20295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCN55_RS20305	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HCN55_RS20310	COG1091	dTDP-4-dehydrorhamnose reductase activity
HCN55_RS20315	COG1088	dTDP-glucose 4,6-dehydratase activity
HCN55_RS20320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCN55_RS20325	COG3980	spore coat polysaccharide biosynthesis protein
HCN55_RS20330	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HCN55_RS20335	COG2089	acid synthase
HCN55_RS20340	COG0456	acetyltransferase
HCN55_RS20345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCN55_RS20350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCN55_RS20355	COG0463	Glycosyl transferase, family 2
HCN55_RS20365	COG2363	Small membrane protein
HCN55_RS20370	COG2233	PERMEase
HCN55_RS20380	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS20385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HCN55_RS20390	COG1216	Glycosyl transferase, family 2
HCN55_RS20405	COG1695	Transcriptional regulator
HCN55_RS20410	COG0351	phosphomethylpyrimidine kinase
HCN55_RS20420	COG1621	beta-fructofuranosidase activity
HCN55_RS20425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS20425	COG1263	PTS System
HCN55_RS20430	COG2116	formate transmembrane transporter activity
HCN55_RS20435	COG3711	transcriptional antiterminator
HCN55_RS20445	COG1404	Belongs to the peptidase S8 family
HCN55_RS20450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS20455	COG0778	Nitroreductase
HCN55_RS20460	COG0772	Belongs to the SEDS family
HCN55_RS20470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HCN55_RS20475	COG1845	cytochrome c oxidase, subunit III
HCN55_RS20480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCN55_RS20485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCN55_RS20490	COG2261	transglycosylase associated protein
HCN55_RS20495	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCN55_RS20500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HCN55_RS20505	COG2246	polysaccharide biosynthetic process
HCN55_RS20510	COG1309	transcriptional regulator
HCN55_RS20520	COG3162	membrane
HCN55_RS20525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCN55_RS20530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCN55_RS20535	COG2837	iron assimilation
HCN55_RS20540	COG2822	iron ion transport
HCN55_RS20545	COG0672	)-iron permease
HCN55_RS20550	COG0352	thiamine-phosphate diphosphorylase activity
HCN55_RS20555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HCN55_RS20560	COG0583	DNA-binding transcription factor activity
HCN55_RS20565	COG1380	Effector of murein hydrolase LrgA
HCN55_RS20570	COG1346	cytolysis
HCN55_RS20575	COG2814	Major facilitator Superfamily
HCN55_RS20580	COG4895	conserved protein (DUF2196)
HCN55_RS20585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCN55_RS20590	COG0346	lactoylglutathione lyase activity
HCN55_RS20600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCN55_RS20605	COG1404	Belongs to the peptidase S8 family
HCN55_RS20610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS20610	COG1263	PTS System
HCN55_RS20615	COG3711	transcriptional antiterminator
HCN55_RS20620	COG1442	glycosyl transferase family 8
HCN55_RS20625	COG5522	Integral membrane protein (intg_mem_TP0381)
HCN55_RS20630	COG1846	Transcriptional regulator
HCN55_RS20635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCN55_RS20640	COG2234	aminopeptidase activity
HCN55_RS20645	COG2357	RelA SpoT domain protein
HCN55_RS20650	COG1575	Belongs to the MenA family. Type 1 subfamily
HCN55_RS20665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCN55_RS20670	COG1696	Membrane protein involved in D-alanine export
HCN55_RS20675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCN55_RS20680	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCN55_RS20685	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HCN55_RS20690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCN55_RS20695	COG1486	melibiose metabolic process
HCN55_RS20700	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCN55_RS20705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCN55_RS20710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCN55_RS20715	COG3711	transcriptional antiterminator
HCN55_RS20715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCN55_RS20725	COG2094	Belongs to the DNA glycosylase MPG family
HCN55_RS20730	COG0753	catalase activity
HCN55_RS20735	COG2814	Major facilitator Superfamily
HCN55_RS20740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCN55_RS20745	COG1131	(ABC) transporter
HCN55_RS20765	COG1595	DNA-templated transcription, initiation
HCN55_RS20770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HCN55_RS20775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HCN55_RS20780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCN55_RS20785	COG4988	ABC transporter
HCN55_RS20790	COG1294	oxidase, subunit
HCN55_RS20795	COG1271	oxidase subunit
HCN55_RS20800	COG3493	citrate carrier protein
HCN55_RS20805	COG0501	Belongs to the peptidase M48B family
HCN55_RS20815	COG0726	polysaccharide deacetylase
HCN55_RS20820	COG3842	ATPase activity
HCN55_RS20825	COG2508	Transcriptional regulator
HCN55_RS20830	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS20835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCN55_RS20845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCN55_RS20850	COG1881	PFAM PEBP family protein
HCN55_RS20855	COG0583	DNA-binding transcription factor activity
HCN55_RS20865	COG4585	Histidine kinase
HCN55_RS20870	COG2197	response regulator
HCN55_RS20875	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCN55_RS20885	COG4894	glucomannan catabolic process
HCN55_RS20890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCN55_RS20895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HCN55_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS20905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCN55_RS20910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCN55_RS20915	COG2610	gluconate transmembrane transporter activity
HCN55_RS20920	COG0500	methyltransferase
HCN55_RS20925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCN55_RS20940	COG0753	catalase activity
HCN55_RS20940	COG0693	protein deglycase activity
HCN55_RS20945	COG2851	Citrate transporter
HCN55_RS20950	COG2273	Hydrolase Family 16
HCN55_RS20955	COG3711	transcriptional antiterminator
HCN55_RS20965	COG2270	Major facilitator Superfamily
HCN55_RS20970	COG0513	Belongs to the DEAD box helicase family
HCN55_RS20975	COG3401	FG-GAP repeat protein
HCN55_RS20975	COG2755	lipolytic protein G-D-S-L family
HCN55_RS21030	COG3209	COG3209 Rhs family protein
HCN55_RS21035	COG0697	spore germination
HCN55_RS21040	COG0589	response to stress
HCN55_RS21045	COG2723	6-phospho-beta-galactosidase activity
HCN55_RS21050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCN55_RS21050	COG1263	PTS System
HCN55_RS21050	COG2190	(PTS) system
HCN55_RS21065	COG5444	nuclease activity
HCN55_RS21080	COG3507	Belongs to the glycosyl hydrolase 43 family
HCN55_RS21095	COG2986	histidine ammonia-lyase
HCN55_RS21100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HCN55_RS21105	COG1228	amidohydrolase
HCN55_RS21110	COG0010	Belongs to the arginase family
HCN55_RS21115	COG0833	amino acid
HCN55_RS21120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HCN55_RS21125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCN55_RS21130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HCN55_RS21135	COG2390	Transcriptional regulator
HCN55_RS21145	COG3192	ethanolamine utilization protein
HCN55_RS21150	COG2079	MmgE PrpD family protein
HCN55_RS21155	COG1473	amidohydrolase
HCN55_RS21160	COG1126	abc transporter atp-binding protein
HCN55_RS21165	COG0765	amino acid transport
HCN55_RS21170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCN55_RS21175	COG0456	acetyltransferase
HCN55_RS21180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCN55_RS21190	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HCN55_RS21195	COG0561	phosphatase activity
HCN55_RS21225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCN55_RS21230	COG5294	Protein conserved in bacteria
HCN55_RS21235	COG0577	efflux transmembrane transporter activity
HCN55_RS21240	COG1136	(ABC) transporter
HCN55_RS21245	COG2205	protein histidine kinase activity
HCN55_RS21250	COG0745	RESPONSE REGULATOR receiver
HCN55_RS21255	COG0191	fructose-bisphosphate aldolase activity
HCN55_RS21260	COG1082	Xylose isomerase domain protein TIM barrel
HCN55_RS21265	COG1082	Xylose isomerase domain protein TIM barrel
HCN55_RS21270	COG0673	inositol 2-dehydrogenase activity
HCN55_RS21275	COG2814	Major facilitator Superfamily
HCN55_RS21280	COG1082	Xylose isomerase domain protein TIM barrel
HCN55_RS21285	COG3962	Belongs to the TPP enzyme family
HCN55_RS21290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCN55_RS21295	COG3718	enzyme involved in inositol metabolism
HCN55_RS21300	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS21305	COG1349	DNA-binding transcription factor activity
HCN55_RS21310	COG0667	Aldo Keto reductase
HCN55_RS21325	COG2814	Major facilitator Superfamily
HCN55_RS21330	COG0326	Molecular chaperone. Has ATPase activity
HCN55_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS21345	COG1309	transcriptional regulator
HCN55_RS21350	COG1012	belongs to the aldehyde dehydrogenase family
HCN55_RS21355	COG0456	acetyltransferase
HCN55_RS21360	COG2850	peptidyl-arginine hydroxylation
HCN55_RS21365	COG2226	methyltransferase
HCN55_RS21380	COG0367	asparagine synthase
HCN55_RS21385	COG2814	Major facilitator Superfamily
HCN55_RS21390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HCN55_RS21400	COG1714	RDD family
HCN55_RS21405	COG2311	Membrane
HCN55_RS21410	COG1917	Cupin 2, conserved barrel domain protein
HCN55_RS21415	COG1309	transcriptional regulator
HCN55_RS21420	COG1028	Short-chain dehydrogenase reductase Sdr
HCN55_RS21425	COG1846	Transcriptional regulator
HCN55_RS21430	COG1380	Effector of murein hydrolase LrgA
HCN55_RS21435	COG1346	cytolysis
HCN55_RS21440	COG5039	Polysaccharide pyruvyl transferase
HCN55_RS21445	COG1929	Belongs to the glycerate kinase type-1 family
HCN55_RS21450	COG1802	Transcriptional regulator
HCN55_RS21455	COG1070	Carbohydrate kinase
HCN55_RS21460	COG2610	gluconate transmembrane transporter activity
HCN55_RS21465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCN55_RS21470	COG0450	alkyl hydroperoxide reductase
HCN55_RS21475	COG3634	alkyl hydroperoxide reductase activity
HCN55_RS21480	COG2723	6-phospho-beta-galactosidase activity
HCN55_RS21490	COG2188	Transcriptional regulator
HCN55_RS21505	COG1131	(ABC) transporter
HCN55_RS21510	COG1994	Peptidase M50
HCN55_RS21515	COG0535	radical SAM domain protein
HCN55_RS21525	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HCN55_RS21530	COG5293	efflux transmembrane transporter activity
HCN55_RS21540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HCN55_RS21545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HCN55_RS21560	COG1063	alcohol dehydrogenase
HCN55_RS21580	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HCN55_RS21585	COG0456	acetyltransferase
HCN55_RS21590	COG0457	Tetratricopeptide repeat
HCN55_RS21600	COG0010	Belongs to the arginase family
HCN55_RS21605	COG0833	amino acid
HCN55_RS21610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCN55_RS21615	COG3829	transcription factor binding
HCN55_RS21635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCN55_RS21640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCN55_RS21645	COG4853	Protein conserved in bacteria
HCN55_RS21650	COG4863	YycH protein
HCN55_RS21655	COG5002	protein histidine kinase activity
HCN55_RS21660	COG0745	RESPONSE REGULATOR receiver
HCN55_RS21690	COG0346	lactoylglutathione lyase activity
HCN55_RS21695	COG0305	Participates in initiation and elongation during chromosome replication
HCN55_RS21710	COG3093	addiction module antidote protein HigA
HCN55_RS21715	COG2807	transmembrane transport
HCN55_RS21720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HCN55_RS21725	COG0359	binds to the 23S rRNA
HCN55_RS21730	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HCN55_RS21735	COG4241	membrane
HCN55_RS21745	COG5577	PFAM Coat F domain
HCN55_RS21750	COG1733	regulation of RNA biosynthetic process
HCN55_RS21755	COG1227	inorganic diphosphatase activity
HCN55_RS21770	COG2271	Major facilitator Superfamily
HCN55_RS21805	COG1131	(ABC) transporter
HCN55_RS21820	COG4319	ketosteroid isomerase
HCN55_RS21825	COG1357	PFAM Pentapeptide repeats (8 copies)
HCN55_RS21830	COG2814	Major facilitator Superfamily
HCN55_RS21835	COG0583	DNA-binding transcription factor activity
HCN55_RS21840	COG2153	protein acetylation
HCN55_RS21855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCN55_RS21860	COG1846	Transcriptional regulator
HCN55_RS21865	COG2153	protein acetylation
HCN55_RS21870	COG2364	Membrane
HCN55_RS21875	COG0456	acetyltransferase
HCN55_RS21880	COG2315	Protein conserved in bacteria
HCN55_RS21885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCN55_RS21895	COG2814	Major facilitator Superfamily
HCN55_RS21905	COG1331	Highly conserved protein containing a thioredoxin domain
HCN55_RS21910	COG0789	Transcriptional regulator
HCN55_RS21915	COG0697	spore germination
HCN55_RS21920	COG1331	Highly conserved protein containing a thioredoxin domain
HCN55_RS21925	COG1266	CAAX protease self-immunity
HCN55_RS21930	COG2814	Major facilitator Superfamily
HCN55_RS21930	COG0477	Major facilitator Superfamily
HCN55_RS21935	COG0110	maltose O-acetyltransferase activity
HCN55_RS21940	COG0346	lactoylglutathione lyase activity
HCN55_RS21945	COG1609	Transcriptional regulator
HCN55_RS21950	COG0708	Exodeoxyribonuclease III
HCN55_RS21955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HCN55_RS21960	COG0629	single-stranded DNA binding
HCN55_RS21965	COG0360	Binds together with S18 to 16S ribosomal RNA
HCN55_RS21970	COG0012	GTP binding
HCN55_RS21975	COG0243	molybdopterin cofactor binding
HCN55_RS21980	COG4481	Protein conserved in bacteria
HCN55_RS21985	COG3949	Membrane
HCN55_RS21995	COG1475	DNA binding
HCN55_RS22000	COG1192	Involved in chromosome partitioning
HCN55_RS22010	COG1475	DNA binding
HCN55_RS22015	COG0357	Ribosomal RNA small subunit methyltransferase G
HCN55_RS22020	COG0445	tRNA wobble uridine modification
HCN55_RS22025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HCN55_RS22030	COG1847	R3H domain protein
HCN55_RS22035	COG0706	membrane insertase activity
HCN55_RS22040	COG0594	ribonuclease P activity