locus-tag	class	description
BTDUT50_RS00010	COG1254	Belongs to the acylphosphatase family
BTDUT50_RS00025	COG0010	Belongs to the arginase family
BTDUT50_RS00035	COG0861	Integral membrane protein TerC family
BTDUT50_RS00040	COG0791	NLP P60 protein
BTDUT50_RS00040	COG1388	LysM domain
BTDUT50_RS00060	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BTDUT50_RS00075	COG2211	Major facilitator Superfamily
BTDUT50_RS00085	COG2076	Multidrug Resistance protein
BTDUT50_RS00090	COG2076	Multidrug Resistance protein
BTDUT50_RS00110	COG0813	purine-nucleoside phosphorylase activity
BTDUT50_RS00135	COG3335	DDE superfamily endonuclease
BTDUT50_RS00170	COG1785	Belongs to the alkaline phosphatase family
BTDUT50_RS00185	COG1597	lipid kinase activity
BTDUT50_RS00195	COG5002	protein histidine kinase activity
BTDUT50_RS00205	COG1842	Phage shock protein A
BTDUT50_RS00215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTDUT50_RS00220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTDUT50_RS00260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTDUT50_RS00265	COG0154	amidase activity
BTDUT50_RS00270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTDUT50_RS00275	COG1115	amino acid carrier protein
BTDUT50_RS00280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BTDUT50_RS00295	COG1012	belongs to the aldehyde dehydrogenase family
BTDUT50_RS00300	COG4851	CamS sex pheromone cAM373 precursor
BTDUT50_RS00305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTDUT50_RS00315	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BTDUT50_RS00320	COG4496	protein, YerC YecD
BTDUT50_RS00325	COG1470	cell adhesion involved in biofilm formation
BTDUT50_RS00330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BTDUT50_RS00340	COG0151	Belongs to the GarS family
BTDUT50_RS00345	COG0138	bifunctional purine biosynthesis protein purh
BTDUT50_RS00350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BTDUT50_RS00355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTDUT50_RS00360	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BTDUT50_RS00365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTDUT50_RS00370	COG0047	phosphoribosylformylglycinamidine synthase activity
BTDUT50_RS00375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTDUT50_RS00380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTDUT50_RS00385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTDUT50_RS00390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTDUT50_RS00395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTDUT50_RS00400	COG0071	Belongs to the small heat shock protein (HSP20) family
BTDUT50_RS00420	COG2252	PERMEase
BTDUT50_RS00425	COG0519	Catalyzes the synthesis of GMP from XMP
BTDUT50_RS00425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTDUT50_RS00435	COG1247	-acetyltransferase
BTDUT50_RS00440	COG0459	protein refolding
BTDUT50_RS00445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTDUT50_RS00450	COG1266	CAAX protease self-immunity
BTDUT50_RS00460	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BTDUT50_RS00465	COG0488	(ABC) transporter
BTDUT50_RS00470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTDUT50_RS00480	COG1214	PFAM Peptidase M22, glycoprotease
BTDUT50_RS00485	COG0802	atpase or kinase
BTDUT50_RS00530	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTDUT50_RS00570	COG3091	SprT-like family
BTDUT50_RS00580	COG2183	response to ionizing radiation
BTDUT50_RS00585	COG2337	Toxic component of a toxin-antitoxin (TA) module
BTDUT50_RS00590	COG0864	Transcriptional regulator
BTDUT50_RS00595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTDUT50_RS00600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BTDUT50_RS00605	COG0736	holo-[acyl-carrier-protein] synthase activity
BTDUT50_RS00610	COG0513	Belongs to the DEAD box helicase family
BTDUT50_RS00615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BTDUT50_RS00620	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTDUT50_RS00640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTDUT50_RS00655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTDUT50_RS00660	COG1024	Enoyl-CoA hydratase
BTDUT50_RS00665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTDUT50_RS00670	COG0511	ligase activity, forming carbon-carbon bonds
BTDUT50_RS00675	COG0439	Biotin carboxylase
BTDUT50_RS00685	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS00700	COG0492	ferredoxin-NADP+ reductase activity
BTDUT50_RS00720	COG1917	Cupin 2, conserved barrel domain protein
BTDUT50_RS00720	COG2207	Transcriptional regulator
BTDUT50_RS00725	COG0697	spore germination
BTDUT50_RS00730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTDUT50_RS00765	COG3328	transposase activity
BTDUT50_RS00780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BTDUT50_RS00785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTDUT50_RS00790	COG4856	YbbR-like protein
BTDUT50_RS00795	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BTDUT50_RS00800	COG5662	AntiSigma factor
BTDUT50_RS00805	COG1595	DNA-templated transcription, initiation
BTDUT50_RS00880	COG0726	polysaccharide deacetylase
BTDUT50_RS00885	COG2194	sulfuric ester hydrolase activity
BTDUT50_RS00895	COG0489	protein tyrosine kinase activity
BTDUT50_RS00900	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTDUT50_RS00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTDUT50_RS00915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTDUT50_RS00920	COG0101	tRNA pseudouridine synthase activity
BTDUT50_RS00925	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTDUT50_RS00930	COG1122	ATPase activity
BTDUT50_RS00935	COG1122	ATPase activity
BTDUT50_RS00940	COG0203	ribosomal protein L17
BTDUT50_RS00945	COG0202	RNA polymerase activity
BTDUT50_RS00950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTDUT50_RS00955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTDUT50_RS00960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTDUT50_RS00965	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTDUT50_RS00970	COG0024	Methionine aminopeptidase
BTDUT50_RS00975	COG0563	adenylate kinase activity
BTDUT50_RS00980	COG0201	protein transport
BTDUT50_RS00985	COG0200	Binds to the 23S rRNA
BTDUT50_RS00990	COG1841	ribosomal large subunit assembly
BTDUT50_RS00995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTDUT50_RS01000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTDUT50_RS01005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTDUT50_RS01010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTDUT50_RS01015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTDUT50_RS01020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTDUT50_RS01025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTDUT50_RS01030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTDUT50_RS01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTDUT50_RS01045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTDUT50_RS01050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTDUT50_RS01055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTDUT50_RS01060	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTDUT50_RS01065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTDUT50_RS01070	COG0089	rRNA binding
BTDUT50_RS01075	COG0088	Forms part of the polypeptide exit tunnel
BTDUT50_RS01080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTDUT50_RS01095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTDUT50_RS01100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTDUT50_RS01105	COG0049	tRNA binding
BTDUT50_RS01110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTDUT50_RS01115	COG1358	cellular component organization or biogenesis
BTDUT50_RS01120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTDUT50_RS01125	COG0085	RNA polymerase activity
BTDUT50_RS01130	COG2813	Specifically methylates the guanine in position
BTDUT50_RS01135	COG0222	ribosome binding
BTDUT50_RS01140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTDUT50_RS01145	COG0081	regulation of translation
BTDUT50_RS01155	COG0250	Participates in transcription elongation, termination and antitermination
BTDUT50_RS01160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTDUT50_RS01165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTDUT50_RS01175	COG3688	RNA-binding protein containing a PIN domain
BTDUT50_RS01180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTDUT50_RS01185	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BTDUT50_RS01190	COG0215	cysteine-tRNA ligase activity
BTDUT50_RS01195	COG1045	serine acetyltransferase
BTDUT50_RS01200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTDUT50_RS01205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTDUT50_RS01210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTDUT50_RS01215	COG4956	integral membrane protein (PIN domain superfamily)
BTDUT50_RS01220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BTDUT50_RS01225	COG0542	response to heat
BTDUT50_RS01230	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BTDUT50_RS01235	COG3880	PFAM UvrB UvrC protein
BTDUT50_RS01285	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTDUT50_RS01315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTDUT50_RS01320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BTDUT50_RS01325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BTDUT50_RS01330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BTDUT50_RS01335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTDUT50_RS01340	COG0512	Glutamine amidotransferase of anthranilate synthase
BTDUT50_RS01345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BTDUT50_RS01350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTDUT50_RS01355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTDUT50_RS01360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTDUT50_RS01365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTDUT50_RS01370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BTDUT50_RS01375	COG0037	tRNA processing
BTDUT50_RS01380	COG0515	serine threonine protein kinase
BTDUT50_RS01385	COG2304	oxidoreductase activity
BTDUT50_RS01390	COG2208	phosphoserine phosphatase activity
BTDUT50_RS01405	COG1098	S1 RNA binding domain
BTDUT50_RS01410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BTDUT50_RS01425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BTDUT50_RS01430	COG3956	TIGRFAM MazG family protein
BTDUT50_RS01435	COG2244	polysaccharide biosynthetic process
BTDUT50_RS01440	COG2002	toxin-antitoxin pair type II binding
BTDUT50_RS01455	COG0193	aminoacyl-tRNA hydrolase activity
BTDUT50_RS01460	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTDUT50_RS01470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTDUT50_RS01475	COG2088	sporulation resulting in formation of a cellular spore
BTDUT50_RS01480	COG0251	oxidation-reduction process
BTDUT50_RS01490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTDUT50_RS01495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTDUT50_RS01500	COG4466	Protein conserved in bacteria
BTDUT50_RS01510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTDUT50_RS01520	COG3584	3D domain protein
BTDUT50_RS01520	COG3583	domain protein
BTDUT50_RS01525	COG0084	hydrolase, TatD family'
BTDUT50_RS01535	COG2002	toxin-antitoxin pair type II binding
BTDUT50_RS01540	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BTDUT50_RS01545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BTDUT50_RS01550	COG4467	Involved in initiation control of chromosome replication
BTDUT50_RS01555	COG1774	PSP1 C-terminal conserved region
BTDUT50_RS01560	COG0470	DNA polymerase III
BTDUT50_RS01565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTDUT50_RS01570	COG1982	Orn Lys Arg decarboxylase major
BTDUT50_RS01615	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTDUT50_RS01620	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTDUT50_RS01625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTDUT50_RS01635	COG0590	tRNA wobble adenosine to inosine editing
BTDUT50_RS01640	COG1428	Deoxynucleoside kinase
BTDUT50_RS01645	COG1428	Deoxynucleoside kinase
BTDUT50_RS01660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BTDUT50_RS01665	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BTDUT50_RS01675	COG0517	IMP dehydrogenase activity
BTDUT50_RS01675	COG0516	GMP reductase activity
BTDUT50_RS01715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BTDUT50_RS01720	COG0187	DNA topoisomerase II activity
BTDUT50_RS01725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BTDUT50_RS01730	COG2501	S4 domain
BTDUT50_RS01735	COG0592	DNA-directed DNA polymerase activity
BTDUT50_RS01740	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTDUT50_RS01745	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTDUT50_RS01750	COG0594	ribonuclease P activity
BTDUT50_RS01755	COG0706	membrane insertase activity
BTDUT50_RS01760	COG1847	R3H domain protein
BTDUT50_RS01765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTDUT50_RS01770	COG0445	tRNA wobble uridine modification
BTDUT50_RS01775	COG0357	Ribosomal RNA small subunit methyltransferase G
BTDUT50_RS01780	COG1475	DNA binding
BTDUT50_RS01785	COG1192	Involved in chromosome partitioning
BTDUT50_RS01790	COG1475	DNA binding
BTDUT50_RS01795	COG1811	Na channel or pump
BTDUT50_RS01805	COG0668	transmembrane transport
BTDUT50_RS01810	COG4481	Protein conserved in bacteria
BTDUT50_RS01815	COG0012	GTP binding
BTDUT50_RS01820	COG0360	Binds together with S18 to 16S ribosomal RNA
BTDUT50_RS01825	COG0629	single-stranded DNA binding
BTDUT50_RS01830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTDUT50_RS01835	COG4241	membrane
BTDUT50_RS01840	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BTDUT50_RS01845	COG0359	binds to the 23S rRNA
BTDUT50_RS01850	COG0305	Participates in initiation and elongation during chromosome replication
BTDUT50_RS01855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTDUT50_RS01870	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS01875	COG5002	protein histidine kinase activity
BTDUT50_RS01885	COG4853	Protein conserved in bacteria
BTDUT50_RS01890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BTDUT50_RS01895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTDUT50_RS01920	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BTDUT50_RS01925	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BTDUT50_RS01955	COG3104	oligopeptide transport
BTDUT50_RS01960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BTDUT50_RS01965	COG1177	transmembrane transport
BTDUT50_RS01970	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTDUT50_RS01975	COG3842	ATPase activity
BTDUT50_RS01985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTDUT50_RS01985	COG0723	plastoquinol--plastocyanin reductase activity
BTDUT50_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
BTDUT50_RS02000	COG1454	alcohol dehydrogenase
BTDUT50_RS02005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTDUT50_RS02010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTDUT50_RS02015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTDUT50_RS02020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BTDUT50_RS02025	COG1882	Formate acetyltransferase
BTDUT50_RS02035	COG0765	amino acid transport
BTDUT50_RS02045	COG0686	Belongs to the AlaDH PNT family
BTDUT50_RS02050	COG2508	Transcriptional regulator
BTDUT50_RS02050	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BTDUT50_RS02060	COG2190	(PTS) system
BTDUT50_RS02065	COG3711	transcriptional antiterminator
BTDUT50_RS02070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTDUT50_RS02070	COG1263	PTS System
BTDUT50_RS02075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTDUT50_RS02080	COG1621	beta-fructofuranosidase activity
BTDUT50_RS02085	COG2390	Transcriptional regulator
BTDUT50_RS02090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BTDUT50_RS02095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BTDUT50_RS02105	COG0295	cytidine deaminase activity
BTDUT50_RS02110	COG0477	Major facilitator Superfamily
BTDUT50_RS02115	COG1216	Glycosyl transferase, family 2
BTDUT50_RS02125	COG0450	alkyl hydroperoxide reductase
BTDUT50_RS02130	COG3634	alkyl hydroperoxide reductase activity
BTDUT50_RS02135	COG0423	glycine-tRNA ligase activity
BTDUT50_RS02145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTDUT50_RS02165	COG0366	Alpha amylase catalytic
BTDUT50_RS02175	COG2363	Small membrane protein
BTDUT50_RS02185	COG3773	Cell wall hydrolase
BTDUT50_RS02195	COG1238	metal cluster binding
BTDUT50_RS02205	COG0280	phosphate acetyltransferase
BTDUT50_RS02210	COG0095	Lipoate-protein ligase
BTDUT50_RS02220	COG4844	belongs to the
BTDUT50_RS02225	COG1078	dGTPase activity
BTDUT50_RS02230	COG3465	dGTPase activity
BTDUT50_RS02240	COG1994	Peptidase M50
BTDUT50_RS02250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTDUT50_RS02255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BTDUT50_RS02260	COG0010	Belongs to the arginase family
BTDUT50_RS02270	COG0018	arginyl-trna synthetase
BTDUT50_RS02275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTDUT50_RS02280	COG2181	nitrate reductase activity
BTDUT50_RS02280	COG0247	lactate metabolic process
BTDUT50_RS02285	COG0183	Belongs to the thiolase family
BTDUT50_RS02290	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTDUT50_RS02295	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS02300	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS02310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BTDUT50_RS02310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BTDUT50_RS02310	COG1703	isobutyryl-CoA mutase activity
BTDUT50_RS02315	COG3343	RNA polymerase activity
BTDUT50_RS02320	COG0504	CTP synthase activity
BTDUT50_RS02325	COG4821	SIS domain
BTDUT50_RS02330	COG2204	response regulator
BTDUT50_RS02340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTDUT50_RS02345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTDUT50_RS02350	COG1494	fructose-1,6-bisphosphatase
BTDUT50_RS02355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTDUT50_RS02360	COG0254	rRNA binding
BTDUT50_RS02365	COG1435	thymidine kinase activity
BTDUT50_RS02380	COG2204	response regulator
BTDUT50_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
BTDUT50_RS02400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTDUT50_RS02405	COG2890	protein-(glutamine-N5) methyltransferase activity
BTDUT50_RS02415	COG0009	L-threonylcarbamoyladenylate synthase
BTDUT50_RS02420	COG1971	Probably functions as a manganese efflux pump
BTDUT50_RS02430	COG0840	transmembrane signaling receptor activity
BTDUT50_RS02435	COG0698	ribose 5-phosphate isomerase
BTDUT50_RS02440	COG4475	Protein of unknown function (DUF436)
BTDUT50_RS02445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTDUT50_RS02450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTDUT50_RS02455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BTDUT50_RS02470	COG0356	it plays a direct role in the translocation of protons across the membrane
BTDUT50_RS02475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTDUT50_RS02480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTDUT50_RS02485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTDUT50_RS02490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTDUT50_RS02495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTDUT50_RS02500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTDUT50_RS02505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTDUT50_RS02510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTDUT50_RS02515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTDUT50_RS02520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTDUT50_RS02525	COG0649	NAD binding
BTDUT50_RS02530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTDUT50_RS02535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTDUT50_RS02540	COG0839	Belongs to the complex I subunit 6 family
BTDUT50_RS02545	COG0713	ATP synthesis coupled electron transport
BTDUT50_RS02560	COG1007	ATP synthesis coupled electron transport
BTDUT50_RS02565	COG4836	Membrane
BTDUT50_RS02575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTDUT50_RS02580	COG2385	sporulation resulting in formation of a cellular spore
BTDUT50_RS02585	COG0739	heme binding
BTDUT50_RS02590	COG1609	Transcriptional regulator
BTDUT50_RS02595	COG1077	Cell shape determining protein MreB Mrl
BTDUT50_RS02600	COG4786	Flagellar basal body rod
BTDUT50_RS02605	COG4786	Flagellar basal body rod
BTDUT50_RS02615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTDUT50_RS02630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BTDUT50_RS02635	COG1609	Transcriptional regulator
BTDUT50_RS02640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTDUT50_RS02645	COG1869	D-ribose catabolic process
BTDUT50_RS02650	COG1129	ABC transporter
BTDUT50_RS02655	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTDUT50_RS02660	COG1879	ABC-type sugar transport system periplasmic component
BTDUT50_RS02690	COG3012	SEC-C Motif Domain Protein
BTDUT50_RS02695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BTDUT50_RS02700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BTDUT50_RS02705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTDUT50_RS02715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BTDUT50_RS02725	COG1959	2 iron, 2 sulfur cluster binding
BTDUT50_RS02730	COG1017	nitric oxide dioxygenase activity
BTDUT50_RS02730	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTDUT50_RS02740	COG0673	inositol 2-dehydrogenase activity
BTDUT50_RS02745	COG2996	Protein conserved in bacteria
BTDUT50_RS02750	COG3012	SEC-C Motif Domain Protein
BTDUT50_RS02750	COG1405	negative regulation of cell septum assembly
BTDUT50_RS02765	COG2244	polysaccharide biosynthetic process
BTDUT50_RS02780	COG0840	transmembrane signaling receptor activity
BTDUT50_RS02785	COG4903	ComK protein
BTDUT50_RS02795	COG0527	aspartate kinase activity
BTDUT50_RS02805	COG3764	Sortase (surface protein transpeptidase)
BTDUT50_RS02820	COG1396	sequence-specific DNA binding
BTDUT50_RS02835	COG0653	protein targeting
BTDUT50_RS02840	COG1404	Belongs to the peptidase S8 family
BTDUT50_RS02845	COG1361	Conserved repeat domain
BTDUT50_RS02875	COG3335	DDE superfamily endonuclease
BTDUT50_RS02890	COG1216	Glycosyl transferase, family 2
BTDUT50_RS02910	COG1216	Glycosyl transferase, family 2
BTDUT50_RS02920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BTDUT50_RS02935	COG1091	dTDP-4-dehydrorhamnose reductase activity
BTDUT50_RS02945	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTDUT50_RS02960	COG3335	DDE superfamily endonuclease
BTDUT50_RS03010	COG5611	PilT protein domain protein
BTDUT50_RS03030	COG2801	Transposase and inactivated derivatives
BTDUT50_RS03075	COG1361	Conserved repeat domain
BTDUT50_RS03085	COG0737	Belongs to the 5'-nucleotidase family
BTDUT50_RS03090	COG1404	Belongs to the peptidase S8 family
BTDUT50_RS03100	COG1361	Conserved repeat domain
BTDUT50_RS03100	COG2911	Protein conserved in bacteria
BTDUT50_RS03100	COG3266	domain, Protein
BTDUT50_RS03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTDUT50_RS03120	COG1316	TRANSCRIPTIONal
BTDUT50_RS03125	COG1739	Uncharacterized protein family UPF0029
BTDUT50_RS03135	COG4585	Histidine kinase
BTDUT50_RS03140	COG2197	response regulator
BTDUT50_RS03145	COG1307	EDD domain protein, DegV family
BTDUT50_RS03150	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BTDUT50_RS03155	COG1040	competence protein
BTDUT50_RS03165	COG2257	FlhB HrpN YscU SpaS Family
BTDUT50_RS03180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BTDUT50_RS03185	COG1728	Protein conserved in bacteria
BTDUT50_RS03205	COG4786	Flagellar basal body rod
BTDUT50_RS03205	COG1256	bacterial-type flagellum assembly
BTDUT50_RS03210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BTDUT50_RS03220	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BTDUT50_RS03225	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BTDUT50_RS03240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BTDUT50_RS03255	COG0457	Tetratricopeptide repeat
BTDUT50_RS03255	COG0463	Glycosyl transferase, family 2
BTDUT50_RS03280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BTDUT50_RS03295	COG1091	dTDP-4-dehydrorhamnose reductase activity
BTDUT50_RS03300	COG0463	Glycosyl transferase, family 2
BTDUT50_RS03305	COG1334	flagellar protein FlaG
BTDUT50_RS03310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BTDUT50_RS03315	COG1516	flagellar protein fliS
BTDUT50_RS03350	COG0653	protein targeting
BTDUT50_RS03370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTDUT50_RS03380	COG2884	Cell division ATP-binding protein ftsE
BTDUT50_RS03385	COG2177	Part of the ABC transporter FtsEX involved in
BTDUT50_RS03390	COG0739	heme binding
BTDUT50_RS03395	COG3409	Peptidoglycan-binding domain 1 protein
BTDUT50_RS03395	COG0793	Belongs to the peptidase S41A family
BTDUT50_RS03400	COG0789	Transcriptional regulator
BTDUT50_RS03405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTDUT50_RS03410	COG4897	Protein conserved in bacteria
BTDUT50_RS03415	COG0556	nucleotide-excision repair
BTDUT50_RS03420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTDUT50_RS03435	COG1950	PFAM Membrane protein of
BTDUT50_RS03440	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTDUT50_RS03445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTDUT50_RS03450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BTDUT50_RS03455	COG0546	phosphoglycolate phosphatase activity
BTDUT50_RS03460	COG0110	maltose O-acetyltransferase activity
BTDUT50_RS03465	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTDUT50_RS03470	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTDUT50_RS03475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTDUT50_RS03480	COG0131	Imidazoleglycerol-phosphate dehydratase
BTDUT50_RS03485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BTDUT50_RS03490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTDUT50_RS03495	COG0107	imidazoleglycerol-phosphate synthase activity
BTDUT50_RS03500	COG0140	phosphoribosyl-ATP diphosphatase activity
BTDUT50_RS03500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTDUT50_RS03505	COG0457	Tetratricopeptide repeat
BTDUT50_RS03510	COG0492	ferredoxin-NADP+ reductase activity
BTDUT50_RS03515	COG1051	belongs to the nudix hydrolase family
BTDUT50_RS03520	COG1660	Displays ATPase and GTPase activities
BTDUT50_RS03525	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BTDUT50_RS03530	COG1481	regulation of sporulation
BTDUT50_RS03535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTDUT50_RS03540	COG0740	serine-type endopeptidase activity
BTDUT50_RS03550	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTDUT50_RS03570	COG0126	phosphoglycerate kinase activity
BTDUT50_RS03575	COG0149	triose-phosphate isomerase activity
BTDUT50_RS03580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BTDUT50_RS03585	COG0148	phosphopyruvate hydratase activity
BTDUT50_RS03590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTDUT50_RS03600	COG0557	exoribonuclease II activity
BTDUT50_RS03605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTDUT50_RS03620	COG5577	PFAM Coat F domain
BTDUT50_RS03630	COG0506	proline dehydrogenase activity
BTDUT50_RS03640	COG1024	Enoyl-CoA hydratase
BTDUT50_RS03640	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTDUT50_RS03645	COG0183	Belongs to the thiolase family
BTDUT50_RS03650	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS03655	COG1393	Belongs to the ArsC family
BTDUT50_RS03660	COG0509	glycine decarboxylation via glycine cleavage system
BTDUT50_RS03670	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BTDUT50_RS03675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS03685	COG2873	o-acetylhomoserine
BTDUT50_RS03690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTDUT50_RS03700	COG1464	Belongs to the NlpA lipoprotein family
BTDUT50_RS03710	COG0396	ATPase activity
BTDUT50_RS03715	COG0719	Fe-S assembly protein
BTDUT50_RS03720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BTDUT50_RS03725	COG0822	iron-sulfur transferase activity
BTDUT50_RS03730	COG0719	Fe-S assembly protein
BTDUT50_RS03735	COG1801	Protein of unknown function DUF72
BTDUT50_RS03740	COG0730	response to heat
BTDUT50_RS03745	COG0737	Belongs to the 5'-nucleotidase family
BTDUT50_RS03750	COG3377	Domain of unknown function (DUF1805)
BTDUT50_RS03760	COG0733	neurotransmitter:sodium symporter activity
BTDUT50_RS03770	COG0739	heme binding
BTDUT50_RS03775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTDUT50_RS03785	COG4470	Protein conserved in bacteria
BTDUT50_RS03805	COG2445	Protein of unknown function DUF86
BTDUT50_RS03815	COG0647	UMP catabolic process
BTDUT50_RS03820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTDUT50_RS03825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BTDUT50_RS03830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTDUT50_RS03835	COG0460	homoserine dehydrogenase
BTDUT50_RS03840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BTDUT50_RS03845	COG0083	homoserine kinase activity
BTDUT50_RS03850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BTDUT50_RS03855	COG4837	Protein of unknown function (DUF1462)
BTDUT50_RS03860	COG1252	NADH dehydrogenase
BTDUT50_RS03865	COG4844	belongs to the
BTDUT50_RS03875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTDUT50_RS03880	COG0316	Belongs to the HesB IscA family
BTDUT50_RS03885	COG5416	Lipopolysaccharide assembly protein A domain
BTDUT50_RS03890	COG0492	ferredoxin-NADP+ reductase activity
BTDUT50_RS03895	COG1252	NADH dehydrogenase
BTDUT50_RS03905	COG3584	3D domain protein
BTDUT50_RS03910	COG1268	BioY protein
BTDUT50_RS03935	COG2032	superoxide dismutase activity
BTDUT50_RS03940	COG1522	sequence-specific DNA binding
BTDUT50_RS03945	COG0436	Aminotransferase
BTDUT50_RS03955	COG1098	S1 RNA binding domain
BTDUT50_RS03960	COG2155	Conserved Protein
BTDUT50_RS03980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BTDUT50_RS03990	COG0789	Transcriptional regulator
BTDUT50_RS03995	COG1253	flavin adenine dinucleotide binding
BTDUT50_RS04000	COG0640	Transcriptional regulator
BTDUT50_RS04010	COG1285	pathogenesis
BTDUT50_RS04130	COG3382	B3 4 domain protein
BTDUT50_RS04145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BTDUT50_RS04150	COG2766	serine protein kinase
BTDUT50_RS04155	COG2718	Belongs to the UPF0229 family
BTDUT50_RS04160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS04165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS04165	COG0425	Belongs to the sulfur carrier protein TusA family
BTDUT50_RS04170	COG2210	Belongs to the sulfur carrier protein TusA family
BTDUT50_RS04175	COG0425	Belongs to the sulfur carrier protein TusA family
BTDUT50_RS04180	COG0730	response to heat
BTDUT50_RS04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTDUT50_RS04190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS04195	COG2210	Belongs to the sulfur carrier protein TusA family
BTDUT50_RS04200	COG2738	Putative neutral zinc metallopeptidase
BTDUT50_RS04210	COG0564	pseudouridine synthase activity
BTDUT50_RS04220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS04230	COG0517	IMP dehydrogenase activity
BTDUT50_RS04235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTDUT50_RS04250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTDUT50_RS04260	COG0330	HflC and HflK could
BTDUT50_RS04265	COG2719	SpoVR family
BTDUT50_RS04270	COG1846	Transcriptional regulator
BTDUT50_RS04275	COG0477	Major facilitator Superfamily
BTDUT50_RS04280	COG0366	Alpha amylase catalytic
BTDUT50_RS04305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BTDUT50_RS04310	COG4721	ABC-type cobalt transport system, permease component
BTDUT50_RS04315	COG1122	ATPase activity
BTDUT50_RS04320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTDUT50_RS04325	COG0352	thiamine-phosphate diphosphorylase activity
BTDUT50_RS04330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTDUT50_RS04340	COG2022	thiamine diphosphate biosynthetic process
BTDUT50_RS04345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTDUT50_RS04350	COG0351	phosphomethylpyrimidine kinase
BTDUT50_RS04355	COG1253	flavin adenine dinucleotide binding
BTDUT50_RS04375	COG3842	ATPase activity
BTDUT50_RS04380	COG2508	Transcriptional regulator
BTDUT50_RS04390	COG4399	Belongs to the UPF0754 family
BTDUT50_RS04395	COG3679	Belongs to the UPF0342 family
BTDUT50_RS04400	COG0561	phosphatase activity
BTDUT50_RS04405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTDUT50_RS04420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTDUT50_RS04435	COG1846	Transcriptional regulator
BTDUT50_RS04455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTDUT50_RS04460	COG0537	adenosine 5'-monophosphoramidase activity
BTDUT50_RS04465	COG1131	(ABC) transporter
BTDUT50_RS04475	COG1473	amidohydrolase
BTDUT50_RS04480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS04485	COG2329	Antibiotic biosynthesis monooxygenase
BTDUT50_RS04490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTDUT50_RS04495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTDUT50_RS04500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BTDUT50_RS04505	COG1309	transcriptional regulator
BTDUT50_RS04510	COG1511	domain protein
BTDUT50_RS04515	COG1609	Transcriptional regulator
BTDUT50_RS04520	COG0366	Alpha amylase catalytic
BTDUT50_RS04530	COG3328	transposase activity
BTDUT50_RS04540	COG1234	tRNA 3'-trailer cleavage
BTDUT50_RS04545	COG0517	IMP dehydrogenase activity
BTDUT50_RS04545	COG0617	tRNA 3'-terminal CCA addition
BTDUT50_RS04545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BTDUT50_RS04555	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS04565	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTDUT50_RS04570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTDUT50_RS04575	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BTDUT50_RS04600	COG1999	signal sequence binding
BTDUT50_RS04605	COG0501	Belongs to the peptidase M48B family
BTDUT50_RS04610	COG2224	Isocitrate lyase
BTDUT50_RS04615	COG4903	ComK protein
BTDUT50_RS04620	COG0398	Pfam SNARE associated Golgi protein
BTDUT50_RS04625	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BTDUT50_RS04630	COG1074	ATP-dependent DNA helicase activity
BTDUT50_RS04635	COG0420	3'-5' exonuclease activity
BTDUT50_RS04640	COG0419	ATPase involved in DNA repair
BTDUT50_RS04645	COG1403	HNH endonuclease
BTDUT50_RS04685	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS04690	COG2311	Membrane
BTDUT50_RS04700	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTDUT50_RS04705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTDUT50_RS04715	COG3300	MHYT domain
BTDUT50_RS04715	COG5001	Diguanylate cyclase
BTDUT50_RS04725	COG0367	asparagine synthase
BTDUT50_RS04730	COG0534	Mate efflux family protein
BTDUT50_RS04735	COG2207	Transcriptional regulator
BTDUT50_RS04735	COG1917	Cupin 2, conserved barrel domain protein
BTDUT50_RS04745	COG2182	Extracellular solute-binding protein
BTDUT50_RS04750	COG1175	transmembrane transport
BTDUT50_RS04755	COG3833	ABC-type maltose transport systems, permease component
BTDUT50_RS04760	COG1874	Beta-galactosidase
BTDUT50_RS04760	COG0366	Alpha amylase catalytic
BTDUT50_RS04790	COG1492	cobalamin metabolic process
BTDUT50_RS04800	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BTDUT50_RS04815	COG0646	methionine synthase
BTDUT50_RS04815	COG1410	methionine synthase
BTDUT50_RS04820	COG0646	methionine synthase
BTDUT50_RS04820	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTDUT50_RS04825	COG1666	GTP binding
BTDUT50_RS04830	COG1744	ABC transporter substrate-binding protein PnrA-like
BTDUT50_RS04835	COG0840	transmembrane signaling receptor activity
BTDUT50_RS04845	COG1307	EDD domain protein, DegV family
BTDUT50_RS04850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTDUT50_RS04860	COG0561	phosphatase activity
BTDUT50_RS04865	COG1073	alpha beta
BTDUT50_RS04875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTDUT50_RS04880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTDUT50_RS04885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTDUT50_RS04890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTDUT50_RS04910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTDUT50_RS04920	COG0542	response to heat
BTDUT50_RS04930	COG2267	carboxylic ester hydrolase activity
BTDUT50_RS04935	COG1744	ABC transporter substrate-binding protein PnrA-like
BTDUT50_RS04940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTDUT50_RS04945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTDUT50_RS04950	COG5504	Zn-dependent protease
BTDUT50_RS04965	COG0180	Tryptophanyl-tRNA synthetase
BTDUT50_RS04975	COG4166	transmembrane transport
BTDUT50_RS04985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTDUT50_RS04990	COG0444	Belongs to the ABC transporter superfamily
BTDUT50_RS04995	COG4608	Belongs to the ABC transporter superfamily
BTDUT50_RS05005	COG1393	Belongs to the ArsC family
BTDUT50_RS05010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTDUT50_RS05015	COG4862	establishment of competence for transformation
BTDUT50_RS05025	COG1164	Oligoendopeptidase f
BTDUT50_RS05030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BTDUT50_RS05035	COG2346	COG2346, Truncated hemoglobins
BTDUT50_RS05040	COG0741	lytic transglycosylase activity
BTDUT50_RS05045	COG4116	CYTH
BTDUT50_RS05055	COG2357	RelA SpoT domain protein
BTDUT50_RS05065	COG0564	pseudouridine synthase activity
BTDUT50_RS05070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTDUT50_RS05075	COG0772	Belongs to the SEDS family
BTDUT50_RS05080	COG2239	Acts as a magnesium transporter
BTDUT50_RS05095	COG3335	DDE superfamily endonuclease
BTDUT50_RS05165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTDUT50_RS05180	COG2323	membrane
BTDUT50_RS05190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS05210	COG0210	DNA helicase
BTDUT50_RS05215	COG2323	membrane
BTDUT50_RS05220	COG2153	protein acetylation
BTDUT50_RS05225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BTDUT50_RS05230	COG2382	esterase
BTDUT50_RS05240	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTDUT50_RS05245	COG0662	Cupin 2, conserved barrel domain protein
BTDUT50_RS05255	COG1970	mechanosensitive ion channel activity
BTDUT50_RS05260	COG3384	dioxygenase
BTDUT50_RS05265	COG0626	cystathionine gamma-synthase activity
BTDUT50_RS05270	COG0626	cystathionine gamma-synthase activity
BTDUT50_RS05275	COG1418	mRNA catabolic process
BTDUT50_RS05285	COG0582	viral genome integration into host DNA
BTDUT50_RS05325	COG2217	Heavy metal translocating P-type atpase
BTDUT50_RS05355	COG3850	Histidine kinase
BTDUT50_RS05355	COG5002	protein histidine kinase activity
BTDUT50_RS05360	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS05385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS05390	COG0785	Cytochrome C biogenesis protein
BTDUT50_RS05395	COG1937	Protein conserved in bacteria
BTDUT50_RS05400	COG2217	Heavy metal translocating P-type atpase
BTDUT50_RS05415	COG2132	Multicopper oxidase
BTDUT50_RS05425	COG3335	DDE superfamily endonuclease
BTDUT50_RS05450	COG1247	-acetyltransferase
BTDUT50_RS05490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BTDUT50_RS05530	COG2801	Transposase and inactivated derivatives
BTDUT50_RS05600	COG1132	(ABC) transporter
BTDUT50_RS05605	COG1132	(ABC) transporter
BTDUT50_RS05610	COG0494	nUDIX hydrolase
BTDUT50_RS05635	COG1418	mRNA catabolic process
BTDUT50_RS05640	COG0488	(ABC) transporter
BTDUT50_RS05645	COG1413	lyase activity
BTDUT50_RS05665	COG3335	DDE superfamily endonuclease
BTDUT50_RS05690	COG0371	Dehydrogenase
BTDUT50_RS05700	COG2011	ABC-type metal ion transport system permease component
BTDUT50_RS05705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTDUT50_RS05710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTDUT50_RS05710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTDUT50_RS05715	COG1609	Transcriptional regulator
BTDUT50_RS05725	COG1879	ABC-type sugar transport system periplasmic component
BTDUT50_RS05730	COG0673	inositol 2-dehydrogenase activity
BTDUT50_RS05735	COG1129	ABC transporter
BTDUT50_RS05740	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTDUT50_RS05750	COG1082	Xylose isomerase domain protein TIM barrel
BTDUT50_RS05760	COG0697	spore germination
BTDUT50_RS05765	COG2358	TRAP transporter, solute receptor (TAXI family
BTDUT50_RS05790	COG0586	Pfam SNARE associated Golgi protein
BTDUT50_RS05805	COG0515	serine threonine protein kinase
BTDUT50_RS05810	COG1396	sequence-specific DNA binding
BTDUT50_RS05820	COG0252	asparaginase activity
BTDUT50_RS05825	COG1027	Aspartate ammonia-lyase
BTDUT50_RS05840	COG1178	ABC-type Fe3 transport system permease component
BTDUT50_RS05845	COG2182	Extracellular solute-binding protein
BTDUT50_RS05850	COG3842	ATPase activity
BTDUT50_RS05885	COG1609	Transcriptional regulator
BTDUT50_RS05900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BTDUT50_RS05915	COG0463	Glycosyl transferase, family 2
BTDUT50_RS05930	COG0531	amino acid
BTDUT50_RS05935	COG0861	Integral membrane protein TerC family
BTDUT50_RS05940	COG1528	Iron-storage protein
BTDUT50_RS05950	COG0247	lactate metabolic process
BTDUT50_RS05955	COG0277	FAD linked oxidase domain protein
BTDUT50_RS05960	COG3835	regulator
BTDUT50_RS05965	COG0840	transmembrane signaling receptor activity
BTDUT50_RS05970	COG1609	Transcriptional regulator
BTDUT50_RS05975	COG1554	hydrolase, family 65, central catalytic
BTDUT50_RS05980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTDUT50_RS05985	COG1653	transport
BTDUT50_RS05995	COG0395	ABC-type sugar transport system, permease component
BTDUT50_RS06015	COG1620	l-lactate permease
BTDUT50_RS06020	COG2186	Transcriptional regulator
BTDUT50_RS06025	COG0247	lactate metabolic process
BTDUT50_RS06030	COG1139	Iron-sulfur cluster binding protein
BTDUT50_RS06035	COG1556	Lactate utilization protein
BTDUT50_RS06040	COG5002	protein histidine kinase activity
BTDUT50_RS06055	COG1129	ABC transporter
BTDUT50_RS06060	COG1879	ABC-type sugar transport system periplasmic component
BTDUT50_RS06065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BTDUT50_RS06070	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BTDUT50_RS06075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTDUT50_RS06085	COG1850	ribulose-bisphosphate carboxylase activity
BTDUT50_RS06090	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BTDUT50_RS06095	COG0235	Class ii aldolase
BTDUT50_RS06100	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BTDUT50_RS06110	COG3852	Histidine kinase
BTDUT50_RS06120	COG0531	amino acid
BTDUT50_RS06125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTDUT50_RS06135	COG0542	response to heat
BTDUT50_RS06155	COG3949	Membrane
BTDUT50_RS06175	COG0704	Plays a role in the regulation of phosphate uptake
BTDUT50_RS06180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTDUT50_RS06185	COG0720	synthase
BTDUT50_RS06195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTDUT50_RS06200	COG0702	epimerase
BTDUT50_RS06205	COG4873	Protein conserved in bacteria
BTDUT50_RS06230	COG4191	Histidine kinase
BTDUT50_RS06235	COG0778	Nitroreductase
BTDUT50_RS06240	COG1733	regulation of RNA biosynthetic process
BTDUT50_RS06260	COG0840	transmembrane signaling receptor activity
BTDUT50_RS06270	COG2111	Na H antiporter
BTDUT50_RS06280	COG1006	Multisubunit Na H antiporter MnhC subunit
BTDUT50_RS06285	COG0651	ATP synthesis coupled electron transport
BTDUT50_RS06290	COG1863	multisubunit Na H antiporter MnhE subunit
BTDUT50_RS06295	COG2212	antiporter activity
BTDUT50_RS06300	COG1320	monovalent cation:proton antiporter activity
BTDUT50_RS06310	COG0791	NLP P60 protein
BTDUT50_RS06310	COG1388	LysM domain
BTDUT50_RS06315	COG0561	phosphatase activity
BTDUT50_RS06320	COG3711	transcriptional antiterminator
BTDUT50_RS06325	COG2190	(PTS) system
BTDUT50_RS06325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTDUT50_RS06325	COG1263	PTS System
BTDUT50_RS06340	COG0840	transmembrane signaling receptor activity
BTDUT50_RS06355	COG2084	Dehydrogenase
BTDUT50_RS06360	COG0436	Aminotransferase
BTDUT50_RS06400	COG0784	Response regulator, receiver
BTDUT50_RS06400	COG0835	chemotaxis
BTDUT50_RS06425	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS06430	COG5002	protein histidine kinase activity
BTDUT50_RS06460	COG0248	Ppx GppA phosphatase
BTDUT50_RS06470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTDUT50_RS06475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTDUT50_RS06480	COG1408	metallophosphoesterase
BTDUT50_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
BTDUT50_RS06490	COG2200	EAL domain
BTDUT50_RS06500	COG4703	Protein of unknown function (DUF1797)
BTDUT50_RS06505	COG0517	IMP dehydrogenase activity
BTDUT50_RS06510	COG2171	N-acyltransferase activity
BTDUT50_RS06515	COG1473	amidohydrolase
BTDUT50_RS06520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS06525	COG0569	domain protein
BTDUT50_RS06535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BTDUT50_RS06540	COG5503	Protein of unknown function (DUF1447)
BTDUT50_RS06545	COG0561	phosphatase activity
BTDUT50_RS06595	COG1982	Orn Lys Arg decarboxylase major
BTDUT50_RS06620	COG0483	inositol monophosphate 1-phosphatase activity
BTDUT50_RS06630	COG1217	gtp-binding protein TYPA
BTDUT50_RS06645	COG4896	Protein conserved in bacteria
BTDUT50_RS06660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTDUT50_RS06665	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTDUT50_RS06670	COG4838	Belongs to the UPF0358 family
BTDUT50_RS06675	COG0772	Belongs to the SEDS family
BTDUT50_RS06680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BTDUT50_RS06685	COG1612	heme a metabolic process
BTDUT50_RS06690	COG0109	protoheme IX farnesyltransferase activity
BTDUT50_RS06715	COG3336	cytochrome c oxidase
BTDUT50_RS06725	COG0628	permease
BTDUT50_RS06745	COG2340	Cysteine-rich secretory protein family
BTDUT50_RS06765	COG3679	Belongs to the UPF0342 family
BTDUT50_RS06770	COG4471	UPF0298 protein
BTDUT50_RS06785	COG0742	ribosomal rna small subunit methyltransferase
BTDUT50_RS06790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTDUT50_RS06795	COG3314	Sporulation integral membrane protein YlbJ
BTDUT50_RS06800	COG1752	Esterase of the alpha-beta hydrolase superfamily
BTDUT50_RS06805	COG3480	Lon protease (S16) C-terminal proteolytic domain
BTDUT50_RS06810	COG1323	Belongs to the UPF0348 family
BTDUT50_RS06815	COG1399	metal-binding, possibly nucleic acid-binding protein
BTDUT50_RS06820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTDUT50_RS06825	COG1024	Enoyl-CoA hydratase
BTDUT50_RS06835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BTDUT50_RS06845	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BTDUT50_RS06850	COG0275	rRNA processing
BTDUT50_RS06855	COG4839	cell division protein FtsL
BTDUT50_RS06860	COG0768	penicillin binding
BTDUT50_RS06865	COG0768	penicillin binding
BTDUT50_RS06870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTDUT50_RS06875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTDUT50_RS06880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTDUT50_RS06885	COG0772	Belongs to the SEDS family
BTDUT50_RS06890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTDUT50_RS06895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BTDUT50_RS06900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTDUT50_RS06905	COG3879	Bacterial protein of unknown function (DUF881)
BTDUT50_RS06910	COG3879	Bacterial protein of unknown function (DUF881)
BTDUT50_RS06915	COG3856	small basic protein
BTDUT50_RS06920	COG0849	cell division
BTDUT50_RS06925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BTDUT50_RS06935	COG1191	sigma factor activity
BTDUT50_RS06940	COG1191	sigma factor activity
BTDUT50_RS06945	COG1873	PFAM PRC-barrel domain
BTDUT50_RS06960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTDUT50_RS06965	COG1799	cell septum assembly
BTDUT50_RS06970	COG0762	integral membrane protein
BTDUT50_RS06975	COG2302	S4 RNA-binding domain
BTDUT50_RS06980	COG3599	regulation of cell shape
BTDUT50_RS06985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTDUT50_RS06990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTDUT50_RS06995	COG0564	pseudouridine synthase activity
BTDUT50_RS07000	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BTDUT50_RS07010	COG0540	Belongs to the ATCase OTCase family
BTDUT50_RS07015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTDUT50_RS07030	COG0543	2 iron, 2 sulfur cluster binding
BTDUT50_RS07035	COG0167	dihydroorotate dehydrogenase activity
BTDUT50_RS07040	COG0284	orotidine-5'-phosphate decarboxylase activity
BTDUT50_RS07060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BTDUT50_RS07065	COG1561	YicC-like family, N-terminal region
BTDUT50_RS07070	COG0194	GDP metabolic process
BTDUT50_RS07075	COG1758	RNA polymerase activity
BTDUT50_RS07080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTDUT50_RS07085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTDUT50_RS07090	COG0242	peptide deformylase activity
BTDUT50_RS07095	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTDUT50_RS07100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTDUT50_RS07100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTDUT50_RS07105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTDUT50_RS07115	COG2815	serine threonine protein kinase
BTDUT50_RS07115	COG0515	serine threonine protein kinase
BTDUT50_RS07120	COG1162	GTPase activity
BTDUT50_RS07125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTDUT50_RS07130	COG1564	THIamine pyrophosphokinase
BTDUT50_RS07140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTDUT50_RS07145	COG1302	Protein conserved in bacteria
BTDUT50_RS07150	COG1461	Dihydroxyacetone kinase
BTDUT50_RS07160	COG1760	l-serine dehydratase
BTDUT50_RS07165	COG1760	l-serine dehydratase
BTDUT50_RS07170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTDUT50_RS07175	COG1349	DNA-binding transcription factor activity
BTDUT50_RS07180	COG0416	fatty acid biosynthetic process
BTDUT50_RS07185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BTDUT50_RS07190	COG1028	Short-chain dehydrogenase reductase Sdr
BTDUT50_RS07195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTDUT50_RS07200	COG0571	ribonuclease III activity
BTDUT50_RS07210	COG0552	protein localization to endoplasmic reticulum
BTDUT50_RS07215	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BTDUT50_RS07225	COG0228	four-way junction DNA binding
BTDUT50_RS07230	COG1837	Belongs to the UPF0109 family
BTDUT50_RS07240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTDUT50_RS07245	COG0336	Belongs to the RNA methyltransferase TrmD family
BTDUT50_RS07250	COG0335	large ribosomal subunit rRNA binding
BTDUT50_RS07260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BTDUT50_RS07265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTDUT50_RS07275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTDUT50_RS07280	COG0045	succinate-CoA ligase (ADP-forming) activity
BTDUT50_RS07285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BTDUT50_RS07290	COG0758	DNA mediated transformation
BTDUT50_RS07295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTDUT50_RS07300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BTDUT50_RS07305	COG4974	Belongs to the 'phage' integrase family
BTDUT50_RS07310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BTDUT50_RS07315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTDUT50_RS07320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BTDUT50_RS07325	COG1815	bacterial-type flagellum-dependent cell motility
BTDUT50_RS07330	COG1558	bacterial-type flagellum-dependent cell motility
BTDUT50_RS07335	COG1677	Flagellar hook-basal body complex protein FliE
BTDUT50_RS07340	COG1766	The M ring may be actively involved in energy transduction
BTDUT50_RS07345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTDUT50_RS07350	COG1317	bacterial-type flagellum organization
BTDUT50_RS07355	COG1157	protein secretion by the type III secretion system
BTDUT50_RS07360	COG2882	bacterial-type flagellum organization
BTDUT50_RS07370	COG3144	bacterial-type flagellum assembly
BTDUT50_RS07375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BTDUT50_RS07385	COG4786	Flagellar basal body rod
BTDUT50_RS07390	COG1582	Flagellar protein (FlbD)
BTDUT50_RS07395	COG1580	Controls the rotational direction of flagella during chemotaxis
BTDUT50_RS07400	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTDUT50_RS07405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTDUT50_RS07405	COG1776	CheC inhibitor of MCP methylation
BTDUT50_RS07410	COG2201	protein-glutamate methylesterase activity
BTDUT50_RS07415	COG3190	flagellar
BTDUT50_RS07420	COG1338	Plays a role in the flagellum-specific transport system
BTDUT50_RS07425	COG1987	bacterial-type flagellum assembly
BTDUT50_RS07430	COG1684	flagellar biosynthetic protein fliR
BTDUT50_RS07435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTDUT50_RS07440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTDUT50_RS07445	COG1419	protein localization to endoplasmic reticulum
BTDUT50_RS07450	COG0455	bacterial-type flagellum organization
BTDUT50_RS07455	COG2201	protein-glutamate methylesterase activity
BTDUT50_RS07460	COG0643	Histidine kinase
BTDUT50_RS07460	COG2198	Histidine kinase
BTDUT50_RS07465	COG0835	chemotaxis
BTDUT50_RS07470	COG1776	CheC inhibitor of MCP methylation
BTDUT50_RS07475	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTDUT50_RS07485	COG1191	sigma factor activity
BTDUT50_RS07500	COG0052	Belongs to the universal ribosomal protein uS2 family
BTDUT50_RS07505	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTDUT50_RS07510	COG0528	UMP kinase activity
BTDUT50_RS07515	COG0233	cytoplasmic translational termination
BTDUT50_RS07520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTDUT50_RS07525	COG4589	Belongs to the CDS family
BTDUT50_RS07530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTDUT50_RS07535	COG0750	zinc metalloprotease
BTDUT50_RS07540	COG0442	prolyl-tRNA aminoacylation
BTDUT50_RS07545	COG2176	DNA-directed DNA polymerase activity
BTDUT50_RS07555	COG0195	Participates in both transcription termination and antitermination
BTDUT50_RS07560	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BTDUT50_RS07565	COG1358	cellular component organization or biogenesis
BTDUT50_RS07570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTDUT50_RS07575	COG1550	Protein conserved in bacteria
BTDUT50_RS07580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTDUT50_RS07585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTDUT50_RS07590	COG0196	riboflavin kinase activity
BTDUT50_RS07595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTDUT50_RS07600	COG1185	polyribonucleotide nucleotidyltransferase activity
BTDUT50_RS07605	COG0726	polysaccharide deacetylase
BTDUT50_RS07610	COG0612	Peptidase, M16
BTDUT50_RS07615	COG1873	PFAM PRC-barrel domain
BTDUT50_RS07620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTDUT50_RS07625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTDUT50_RS07630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTDUT50_RS07635	COG0527	aspartate kinase activity
BTDUT50_RS07645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BTDUT50_RS07650	COG0740	serine-type endopeptidase activity
BTDUT50_RS07660	COG4980	gas vesicle protein
BTDUT50_RS07660	COG1674	ftsk spoiiie
BTDUT50_RS07665	COG2188	Transcriptional regulator
BTDUT50_RS07670	COG1744	ABC transporter substrate-binding protein PnrA-like
BTDUT50_RS07675	COG3845	ABC transporter
BTDUT50_RS07680	COG4603	Belongs to the binding-protein-dependent transport system permease family
BTDUT50_RS07685	COG1079	Belongs to the binding-protein-dependent transport system permease family
BTDUT50_RS07690	COG2508	Transcriptional regulator
BTDUT50_RS07695	COG1012	belongs to the aldehyde dehydrogenase family
BTDUT50_RS07710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTDUT50_RS07740	COG0579	oxidoreductase
BTDUT50_RS07795	COG1132	(ABC) transporter
BTDUT50_RS07800	COG2312	Erythromycin esterase
BTDUT50_RS07835	COG1959	2 iron, 2 sulfur cluster binding
BTDUT50_RS07840	COG0482	sulfurtransferase activity
BTDUT50_RS07895	COG0640	Transcriptional regulator
BTDUT50_RS07930	COG2816	NAD+ diphosphatase activity
BTDUT50_RS07945	COG1413	lyase activity
BTDUT50_RS07955	COG1051	belongs to the nudix hydrolase family
BTDUT50_RS07960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BTDUT50_RS07975	COG3011	Protein conserved in bacteria
BTDUT50_RS07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS07990	COG1192	Involved in chromosome partitioning
BTDUT50_RS07995	COG5646	InterPro IPR014922
BTDUT50_RS08000	COG3739	integral membrane protein
BTDUT50_RS08015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTDUT50_RS08030	COG0583	DNA-binding transcription factor activity
BTDUT50_RS08035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BTDUT50_RS08040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BTDUT50_RS08045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BTDUT50_RS08050	COG3842	ATPase activity
BTDUT50_RS08055	COG1175	transmembrane transport
BTDUT50_RS08070	COG0584	glycerophosphoryl diester phosphodiesterase
BTDUT50_RS08080	COG2076	Multidrug Resistance protein
BTDUT50_RS08085	COG0393	Putative heavy-metal-binding
BTDUT50_RS08095	COG0640	Transcriptional regulator
BTDUT50_RS08105	COG4377	Putative membrane peptidase family (DUF2324)
BTDUT50_RS08125	COG2223	nitrite transmembrane transporter activity
BTDUT50_RS08130	COG1609	Transcriptional regulator
BTDUT50_RS08135	COG1741	Belongs to the pirin family
BTDUT50_RS08145	COG1846	Transcriptional regulator
BTDUT50_RS08150	COG3773	Cell wall hydrolase
BTDUT50_RS08165	COG1131	(ABC) transporter
BTDUT50_RS08175	COG1309	transcriptional regulator
BTDUT50_RS08180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTDUT50_RS08185	COG1414	Transcriptional regulator
BTDUT50_RS08195	COG2340	Cysteine-rich secretory protein family
BTDUT50_RS08200	COG1742	UPF0060 membrane protein
BTDUT50_RS08210	COG2986	histidine ammonia-lyase
BTDUT50_RS08215	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BTDUT50_RS08220	COG1228	amidohydrolase
BTDUT50_RS08225	COG0010	Belongs to the arginase family
BTDUT50_RS08240	COG0371	Dehydrogenase
BTDUT50_RS08250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTDUT50_RS08260	COG5609	conserved protein (DUF2294)
BTDUT50_RS08270	COG0789	Transcriptional regulator
BTDUT50_RS08285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTDUT50_RS08290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS08295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTDUT50_RS08300	COG0612	Peptidase, M16
BTDUT50_RS08305	COG0612	Peptidase, M16
BTDUT50_RS08310	COG0300	oxidoreductase activity
BTDUT50_RS08325	COG1426	Protein conserved in bacteria
BTDUT50_RS08330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTDUT50_RS08335	COG1546	Belongs to the CinA family
BTDUT50_RS08335	COG1058	Belongs to the CinA family
BTDUT50_RS08355	COG1418	mRNA catabolic process
BTDUT50_RS08360	COG1692	metallophosphoesterase
BTDUT50_RS08365	COG2359	stage V sporulation protein S
BTDUT50_RS08375	COG0674	pyruvate-flavodoxin oxidoreductase activity
BTDUT50_RS08375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BTDUT50_RS08380	COG1013	pyruvate-flavodoxin oxidoreductase activity
BTDUT50_RS08385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTDUT50_RS08390	COG4550	Control of competence regulator ComK, YlbF/YmcA
BTDUT50_RS08400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTDUT50_RS08405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTDUT50_RS08410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTDUT50_RS08415	COG1923	regulation of RNA biosynthetic process
BTDUT50_RS08420	COG0464	growth
BTDUT50_RS08430	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS08435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTDUT50_RS08440	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS08445	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTDUT50_RS08450	COG0183	Belongs to the thiolase family
BTDUT50_RS08455	COG2860	membrane
BTDUT50_RS08460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTDUT50_RS08465	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BTDUT50_RS08470	COG0789	Transcriptional regulator
BTDUT50_RS08475	COG0174	glutamine synthetase
BTDUT50_RS08480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTDUT50_RS08485	COG1388	LysM domain
BTDUT50_RS08490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BTDUT50_RS08495	COG4224	UPF0291 protein
BTDUT50_RS08505	COG3763	UPF0154 protein
BTDUT50_RS08510	COG0785	Cytochrome C biogenesis protein
BTDUT50_RS08515	COG2201	protein-glutamate methylesterase activity
BTDUT50_RS08520	COG4846	Membrane protein involved in cytochrome C biogenesis
BTDUT50_RS08545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTDUT50_RS08555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BTDUT50_RS08565	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTDUT50_RS08595	COG0432	Pfam Uncharacterised protein family UPF0047
BTDUT50_RS08600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BTDUT50_RS08605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BTDUT50_RS08610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BTDUT50_RS08620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BTDUT50_RS08620	COG2199	diguanylate cyclase activity
BTDUT50_RS08625	COG1349	DNA-binding transcription factor activity
BTDUT50_RS08630	COG1105	Belongs to the carbohydrate kinase PfkB family
BTDUT50_RS08635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTDUT50_RS08635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BTDUT50_RS08635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTDUT50_RS08640	COG0716	FMN binding
BTDUT50_RS08645	COG5002	protein histidine kinase activity
BTDUT50_RS08650	COG1587	Uroporphyrinogen-III synthase
BTDUT50_RS08660	COG1988	membrane-bound metal-dependent
BTDUT50_RS08665	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BTDUT50_RS08675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTDUT50_RS08680	COG1984	allophanate hydrolase subunit 2
BTDUT50_RS08685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BTDUT50_RS08690	COG1914	H( )-stimulated, divalent metal cation uptake system
BTDUT50_RS08700	COG2233	PERMEase
BTDUT50_RS08710	COG2814	Major facilitator Superfamily
BTDUT50_RS08715	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BTDUT50_RS08725	COG2521	methyltransferase
BTDUT50_RS08725	COG2136	Putative SAM-dependent methyltransferase
BTDUT50_RS08735	COG1301	dicarboxylic acid transport
BTDUT50_RS08745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTDUT50_RS08750	COG0805	protein transport
BTDUT50_RS08760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTDUT50_RS08765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BTDUT50_RS08770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTDUT50_RS08780	COG1307	EDD domain protein, DegV family
BTDUT50_RS08785	COG1999	signal sequence binding
BTDUT50_RS08790	COG2755	lipolytic protein G-D-S-L family
BTDUT50_RS08805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTDUT50_RS08810	COG1832	CoA-binding protein
BTDUT50_RS08815	COG0187	DNA topoisomerase II activity
BTDUT50_RS08820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BTDUT50_RS08830	COG1263	PTS System
BTDUT50_RS08830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BTDUT50_RS08835	COG0366	Alpha amylase catalytic
BTDUT50_RS08840	COG2188	Transcriptional regulator
BTDUT50_RS08845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTDUT50_RS08850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BTDUT50_RS08855	COG2116	formate transmembrane transporter activity
BTDUT50_RS08860	COG0788	formyltetrahydrofolate deformylase activity
BTDUT50_RS08870	COG1937	Protein conserved in bacteria
BTDUT50_RS08875	COG0714	Associated with various cellular activities
BTDUT50_RS08880	COG4548	von Willebrand factor, type A
BTDUT50_RS08900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BTDUT50_RS08910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTDUT50_RS08915	COG0551	DNA topoisomerase type I activity
BTDUT50_RS08915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BTDUT50_RS08940	COG3335	DDE superfamily endonuclease
BTDUT50_RS08990	COG1119	ATPase activity
BTDUT50_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
BTDUT50_RS09005	COG0697	spore germination
BTDUT50_RS09010	COG0583	DNA-binding transcription factor activity
BTDUT50_RS09015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTDUT50_RS09025	COG0640	Transcriptional regulator
BTDUT50_RS09035	COG3328	transposase activity
BTDUT50_RS09040	COG0523	cobalamin synthesis protein
BTDUT50_RS09045	COG0328	RNA-DNA hybrid ribonuclease activity
BTDUT50_RS09045	COG3341	Caulimovirus viroplasmin
BTDUT50_RS09060	COG0494	nUDIX hydrolase
BTDUT50_RS09070	COG1131	(ABC) transporter
BTDUT50_RS09075	COG2755	lipolytic protein G-D-S-L family
BTDUT50_RS09085	COG1278	Cold shock
BTDUT50_RS09095	COG0826	peptidase U32
BTDUT50_RS09130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTDUT50_RS09135	COG3546	catalase activity
BTDUT50_RS09145	COG3852	Histidine kinase
BTDUT50_RS09150	COG1115	amino acid carrier protein
BTDUT50_RS09155	COG0534	Mate efflux family protein
BTDUT50_RS09175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BTDUT50_RS09180	COG2056	Na+-H+ antiporter family
BTDUT50_RS09190	COG1876	peptidase activity
BTDUT50_RS09210	COG4326	sporulation control protein
BTDUT50_RS09225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTDUT50_RS09245	COG4841	protein insertion into membrane
BTDUT50_RS09250	COG0824	Thioesterase
BTDUT50_RS09270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS09280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BTDUT50_RS09285	COG1755	Isoprenylcysteine carboxyl methyltransferase
BTDUT50_RS09290	COG3424	synthase
BTDUT50_RS09305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTDUT50_RS09310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTDUT50_RS09315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BTDUT50_RS09320	COG1199	ATP-dependent helicase activity
BTDUT50_RS09325	COG0116	Belongs to the methyltransferase superfamily
BTDUT50_RS09360	COG1024	Enoyl-CoA hydratase
BTDUT50_RS09365	COG0352	thiamine-phosphate diphosphorylase activity
BTDUT50_RS09370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BTDUT50_RS09375	COG1151	hydroxylamine reductase activity
BTDUT50_RS09380	COG1525	nuclease
BTDUT50_RS09390	COG1131	(ABC) transporter
BTDUT50_RS09410	COG5001	Diguanylate cyclase
BTDUT50_RS09410	COG3300	MHYT domain
BTDUT50_RS09420	COG0640	Transcriptional regulator
BTDUT50_RS09425	COG1199	ATP-dependent helicase activity
BTDUT50_RS09425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTDUT50_RS09435	COG0004	ammonium transporteR
BTDUT50_RS09440	COG3069	C4-dicarboxylate transmembrane transporter activity
BTDUT50_RS09450	COG0674	pyruvate-flavodoxin oxidoreductase activity
BTDUT50_RS09455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BTDUT50_RS09465	COG1132	(ABC) transporter
BTDUT50_RS09470	COG1132	(ABC) transporter
BTDUT50_RS09480	COG0438	transferase activity, transferring glycosyl groups
BTDUT50_RS09500	COG0386	Belongs to the glutathione peroxidase family
BTDUT50_RS09505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTDUT50_RS09505	COG3153	acetyltransferase
BTDUT50_RS09510	COG0456	acetyltransferase
BTDUT50_RS09530	COG4948	Mandelate Racemase Muconate Lactonizing
BTDUT50_RS09545	COG0697	spore germination
BTDUT50_RS09550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTDUT50_RS09575	COG3853	Toxic anion resistance protein (TelA)
BTDUT50_RS09595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTDUT50_RS09600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTDUT50_RS09600	COG1321	iron dependent repressor
BTDUT50_RS09605	COG1121	(ABC) transporter
BTDUT50_RS09610	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTDUT50_RS09615	COG0531	amino acid
BTDUT50_RS09625	COG3314	Sporulation integral membrane protein YlbJ
BTDUT50_RS09645	COG1272	protein, Hemolysin III
BTDUT50_RS09650	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS09655	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS09665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTDUT50_RS09680	COG1668	transmembrane transport
BTDUT50_RS09685	COG4152	abc transporter atp-binding protein
BTDUT50_RS09695	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTDUT50_RS09700	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTDUT50_RS09705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTDUT50_RS09755	COG1960	acyl-CoA dehydrogenase activity
BTDUT50_RS09765	COG0129	dihydroxy-acid dehydratase activity
BTDUT50_RS09770	COG0493	'glutamate synthase
BTDUT50_RS09780	COG0583	DNA-binding transcription factor activity
BTDUT50_RS09790	COG2246	polysaccharide biosynthetic process
BTDUT50_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
BTDUT50_RS09830	COG0367	asparagine synthase
BTDUT50_RS09835	COG2132	Multicopper oxidase
BTDUT50_RS09850	COG2217	Heavy metal translocating P-type atpase
BTDUT50_RS09855	COG1937	Protein conserved in bacteria
BTDUT50_RS09880	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS09885	COG5002	protein histidine kinase activity
BTDUT50_RS09885	COG3850	Histidine kinase
BTDUT50_RS09915	COG0656	L-ascorbic acid biosynthetic process
BTDUT50_RS09920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BTDUT50_RS09930	COG0697	spore germination
BTDUT50_RS09935	COG0110	maltose O-acetyltransferase activity
BTDUT50_RS09940	COG1968	undecaprenyl-diphosphatase activity
BTDUT50_RS09950	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTDUT50_RS09975	COG2226	methyltransferase
BTDUT50_RS10095	COG0475	glutathione-regulated potassium exporter activity
BTDUT50_RS10095	COG0569	domain protein
BTDUT50_RS10115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTDUT50_RS10120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTDUT50_RS10125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTDUT50_RS10130	COG1120	ATPase activity
BTDUT50_RS10135	COG1929	Belongs to the glycerate kinase type-1 family
BTDUT50_RS10170	COG2217	Heavy metal translocating P-type atpase
BTDUT50_RS10175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTDUT50_RS10200	COG3331	DNA recombination
BTDUT50_RS10205	COG4499	WXG100 protein secretion system (Wss), protein YukC
BTDUT50_RS10205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTDUT50_RS10215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTDUT50_RS10220	COG3935	DnaD domain protein
BTDUT50_RS10225	COG0017	Asparaginyl-tRNA synthetase
BTDUT50_RS10250	COG1199	ATP-dependent helicase activity
BTDUT50_RS10250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTDUT50_RS10255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTDUT50_RS10260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTDUT50_RS10265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTDUT50_RS10275	COG0617	tRNA 3'-terminal CCA addition
BTDUT50_RS10280	COG0438	transferase activity, transferring glycosyl groups
BTDUT50_RS10285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BTDUT50_RS10290	COG1803	Methylglyoxal synthase
BTDUT50_RS10295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BTDUT50_RS10300	COG1694	Mazg nucleotide pyrophosphohydrolase
BTDUT50_RS10305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTDUT50_RS10315	COG4347	Protein of unknown function (DUF1405)
BTDUT50_RS10325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTDUT50_RS10340	COG5582	Belongs to the UPF0302 family
BTDUT50_RS10345	COG0457	Tetratricopeptide repeat
BTDUT50_RS10350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTDUT50_RS10355	COG0287	Prephenate dehydrogenase
BTDUT50_RS10360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTDUT50_RS10365	COG0159	tryptophan synthase activity
BTDUT50_RS10370	COG0133	tryptophan synthase activity
BTDUT50_RS10375	COG0135	phosphoribosylanthranilate isomerase activity
BTDUT50_RS10380	COG0134	indole-3-glycerol-phosphate synthase activity
BTDUT50_RS10385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTDUT50_RS10395	COG4401	Chorismate mutase type I
BTDUT50_RS10400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTDUT50_RS10405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTDUT50_RS10410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BTDUT50_RS10415	COG0105	UTP biosynthetic process
BTDUT50_RS10425	COG2226	methyltransferase
BTDUT50_RS10430	COG0142	geranyltranstransferase activity
BTDUT50_RS10440	COG0302	gtp cyclohydrolase
BTDUT50_RS10450	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BTDUT50_RS10465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTDUT50_RS10470	COG1160	GTP binding
BTDUT50_RS10500	COG0539	negative regulation of cytoplasmic translation
BTDUT50_RS10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTDUT50_RS10520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTDUT50_RS10525	COG2339	peptidase activity
BTDUT50_RS10530	COG3773	Cell wall hydrolase
BTDUT50_RS10530	COG3409	Peptidoglycan-binding domain 1 protein
BTDUT50_RS10535	COG2959	enzyme of heme biosynthesis
BTDUT50_RS10540	COG0492	ferredoxin-NADP+ reductase activity
BTDUT50_RS10545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTDUT50_RS10555	COG4862	establishment of competence for transformation
BTDUT50_RS10560	COG0789	Transcriptional regulator
BTDUT50_RS10565	COG1408	metallophosphoesterase
BTDUT50_RS10585	COG1266	CAAX protease self-immunity
BTDUT50_RS10590	COG0514	ATP-dependent DNA helicase (RecQ)
BTDUT50_RS10595	COG4955	Helix-turn-helix domain
BTDUT50_RS10610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTDUT50_RS10615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BTDUT50_RS10630	COG2096	Adenosyltransferase
BTDUT50_RS10645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BTDUT50_RS10660	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BTDUT50_RS10665	COG1120	ATPase activity
BTDUT50_RS10670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTDUT50_RS10675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTDUT50_RS10680	COG5002	protein histidine kinase activity
BTDUT50_RS10685	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS10690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTDUT50_RS10695	COG1333	cytochrome c biogenesis protein
BTDUT50_RS10700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS10705	COG1187	pseudouridine synthase activity
BTDUT50_RS10710	COG0700	Nucleoside recognition
BTDUT50_RS10715	COG2715	membrane protein required for spore maturation
BTDUT50_RS10720	COG1686	Belongs to the peptidase S11 family
BTDUT50_RS10725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTDUT50_RS10740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTDUT50_RS10745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTDUT50_RS10750	COG1547	Domain of unknown function (DUF309)
BTDUT50_RS10760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTDUT50_RS10765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BTDUT50_RS10765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BTDUT50_RS10770	COG0307	riboflavin synthase, alpha
BTDUT50_RS10775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTDUT50_RS10775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTDUT50_RS10780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTDUT50_RS10785	COG4086	secreted protein
BTDUT50_RS10790	COG0019	diaminopimelate decarboxylase activity
BTDUT50_RS10795	COG0697	spore germination
BTDUT50_RS10810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTDUT50_RS10835	COG2172	sigma factor antagonist activity
BTDUT50_RS10845	COG1686	Belongs to the peptidase S11 family
BTDUT50_RS10865	COG4974	Belongs to the 'phage' integrase family
BTDUT50_RS10875	COG0735	belongs to the Fur family
BTDUT50_RS10880	COG1300	Membrane
BTDUT50_RS10885	COG0494	nUDIX hydrolase
BTDUT50_RS10890	COG0667	Aldo Keto reductase
BTDUT50_RS10905	COG2181	nitrate reductase activity
BTDUT50_RS10910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BTDUT50_RS10920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BTDUT50_RS10930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTDUT50_RS10935	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTDUT50_RS10940	COG0315	cyclic pyranopterin monophosphate synthase activity
BTDUT50_RS10950	COG0314	molybdopterin synthase activity
BTDUT50_RS10955	COG1763	Mo-molybdopterin cofactor biosynthetic process
BTDUT50_RS10960	COG0303	'Molybdopterin
BTDUT50_RS10965	COG0746	molybdenum cofactor guanylyltransferase activity
BTDUT50_RS10975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTDUT50_RS10980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTDUT50_RS10985	COG4149	molybdate abc transporter
BTDUT50_RS10995	COG2223	nitrite transmembrane transporter activity
BTDUT50_RS11030	COG2151	metal-sulfur cluster biosynthetic enzyme
BTDUT50_RS11035	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BTDUT50_RS11055	COG0535	radical SAM domain protein
BTDUT50_RS11065	COG4918	Iron-sulphur cluster biosynthesis
BTDUT50_RS11075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTDUT50_RS11080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BTDUT50_RS11085	COG1902	pentaerythritol trinitrate reductase activity
BTDUT50_RS11095	COG1234	tRNA 3'-trailer cleavage
BTDUT50_RS11100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BTDUT50_RS11105	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BTDUT50_RS11110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BTDUT50_RS11120	COG2195	Cleaves the N-terminal amino acid of tripeptides
BTDUT50_RS11125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTDUT50_RS11130	COG0346	lactoylglutathione lyase activity
BTDUT50_RS11135	COG1376	ErfK ybiS ycfS ynhG family protein
BTDUT50_RS11140	COG4129	membrane
BTDUT50_RS11150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BTDUT50_RS11150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BTDUT50_RS11155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BTDUT50_RS11160	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTDUT50_RS11165	COG0022	dehydrogenase e1 component
BTDUT50_RS11170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BTDUT50_RS11175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTDUT50_RS11190	COG0280	phosphate acetyltransferase
BTDUT50_RS11195	COG3829	transcription factor binding
BTDUT50_RS11195	COG3290	protein histidine kinase activity
BTDUT50_RS11205	COG0584	glycerophosphoryl diester phosphodiesterase
BTDUT50_RS11210	COG3093	addiction module antidote protein HigA
BTDUT50_RS11220	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BTDUT50_RS11255	COG0750	zinc metalloprotease
BTDUT50_RS11260	COG0497	DNA recombination
BTDUT50_RS11270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BTDUT50_RS11275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTDUT50_RS11285	COG1722	exodeoxyribonuclease VII activity
BTDUT50_RS11290	COG1570	exodeoxyribonuclease VII activity
BTDUT50_RS11295	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTDUT50_RS11300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTDUT50_RS11305	COG1302	Protein conserved in bacteria
BTDUT50_RS11310	COG0439	Biotin carboxylase
BTDUT50_RS11315	COG0511	ligase activity, forming carbon-carbon bonds
BTDUT50_RS11355	COG3854	ATPases associated with a variety of cellular activities
BTDUT50_RS11370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTDUT50_RS11375	COG0006	proline dipeptidase activity
BTDUT50_RS11380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTDUT50_RS11390	COG3872	metal-dependent enzyme
BTDUT50_RS11400	COG1752	Esterase of the alpha-beta hydrolase superfamily
BTDUT50_RS11405	COG1321	iron dependent repressor
BTDUT50_RS11410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTDUT50_RS11435	COG0095	Lipoate-protein ligase
BTDUT50_RS11440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS11445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTDUT50_RS11450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTDUT50_RS11455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTDUT50_RS11465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BTDUT50_RS11500	COG4970	Tfp pilus assembly protein FimT
BTDUT50_RS11505	COG4537	Required for transformation and DNA binding
BTDUT50_RS11510	COG1459	type II secretion system
BTDUT50_RS11515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTDUT50_RS11520	COG1393	Belongs to the ArsC family
BTDUT50_RS11540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTDUT50_RS11555	COG1368	sulfuric ester hydrolase activity
BTDUT50_RS11560	COG1940	carbohydrate kinase activity
BTDUT50_RS11565	COG4483	Protein conserved in bacteria
BTDUT50_RS11570	COG0697	spore germination
BTDUT50_RS11580	COG0705	Rhomboid family
BTDUT50_RS11580	COG0457	Tetratricopeptide repeat
BTDUT50_RS11590	COG0039	L-malate dehydrogenase activity
BTDUT50_RS11595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTDUT50_RS11600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTDUT50_RS11605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTDUT50_RS11620	COG0704	Plays a role in the regulation of phosphate uptake
BTDUT50_RS11630	COG0581	inorganic phosphate transmembrane transporter activity
BTDUT50_RS11635	COG0573	inorganic phosphate transmembrane transporter activity
BTDUT50_RS11640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BTDUT50_RS11645	COG0768	penicillin binding
BTDUT50_RS11650	COG0477	Major facilitator Superfamily
BTDUT50_RS11670	COG5521	maltodextrose utilization protein MalA
BTDUT50_RS11675	COG0840	transmembrane signaling receptor activity
BTDUT50_RS11680	COG1388	LysM domain
BTDUT50_RS11685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BTDUT50_RS11690	COG4709	membrane
BTDUT50_RS11695	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BTDUT50_RS11700	COG0735	belongs to the Fur family
BTDUT50_RS11705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTDUT50_RS11710	COG1121	(ABC) transporter
BTDUT50_RS11715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BTDUT50_RS11725	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BTDUT50_RS11740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTDUT50_RS11745	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTDUT50_RS11750	COG2384	SAM-dependent methyltransferase
BTDUT50_RS11755	COG2010	Cytochrome c
BTDUT50_RS11765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTDUT50_RS11775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTDUT50_RS11780	COG0517	IMP dehydrogenase activity
BTDUT50_RS11785	COG1381	Involved in DNA repair and RecF pathway recombination
BTDUT50_RS11795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTDUT50_RS11800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTDUT50_RS11805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTDUT50_RS11810	COG1702	phosphate starvation-inducible protein PhoH
BTDUT50_RS11830	COG4864	UPF0365 protein
BTDUT50_RS11835	COG1030	water channel activity
BTDUT50_RS11840	COG1610	YqeY-like protein
BTDUT50_RS11845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTDUT50_RS11850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTDUT50_RS11860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTDUT50_RS11865	COG2264	protein methyltransferase activity
BTDUT50_RS11870	COG0484	heat shock protein binding
BTDUT50_RS11875	COG0443	Heat shock 70 kDa protein
BTDUT50_RS11880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTDUT50_RS11885	COG1420	regulation of RNA biosynthetic process
BTDUT50_RS11890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTDUT50_RS11895	COG0481	GTPase activity
BTDUT50_RS11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTDUT50_RS11910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BTDUT50_RS11915	COG0268	Binds directly to 16S ribosomal RNA
BTDUT50_RS11920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTDUT50_RS11925	COG1466	dna polymerase III delta subunit
BTDUT50_RS11935	COG2333	competence protein COMEC
BTDUT50_RS11935	COG0658	competence protein
BTDUT50_RS11940	COG2131	deaminase
BTDUT50_RS11945	COG1555	photosystem II stabilization
BTDUT50_RS11945	COG1596	polysaccharide export
BTDUT50_RS11950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BTDUT50_RS11955	COG2226	methyltransferase
BTDUT50_RS11965	COG0799	negative regulation of ribosome biogenesis
BTDUT50_RS11970	COG1713	HD superfamily hydrolase involved in NAD metabolism
BTDUT50_RS11975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTDUT50_RS11980	COG1534	Rna-binding protein
BTDUT50_RS11985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTDUT50_RS11990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BTDUT50_RS11995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BTDUT50_RS12005	COG0688	phosphatidylethanolamine metabolic process
BTDUT50_RS12010	COG1183	phosphatidylcholine synthase activity
BTDUT50_RS12020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BTDUT50_RS12025	COG1360	Flagellar Motor Protein
BTDUT50_RS12030	COG1823	symporter activity
BTDUT50_RS12050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTDUT50_RS12090	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BTDUT50_RS12100	COG0626	cystathionine gamma-synthase activity
BTDUT50_RS12105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BTDUT50_RS12110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTDUT50_RS12115	COG2226	methyltransferase
BTDUT50_RS12130	COG0768	penicillin binding
BTDUT50_RS12135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTDUT50_RS12140	COG0572	uridine kinase
BTDUT50_RS12145	COG0826	peptidase U32
BTDUT50_RS12150	COG0826	peptidase U32
BTDUT50_RS12155	COG4122	O-methyltransferase activity
BTDUT50_RS12160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTDUT50_RS12165	COG3906	Belongs to the UPF0473 family
BTDUT50_RS12170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTDUT50_RS12175	COG4472	Bacterial protein of unknown function (DUF965)
BTDUT50_RS12180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTDUT50_RS12185	COG0628	permease
BTDUT50_RS12200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BTDUT50_RS12210	COG0482	sulfurtransferase activity
BTDUT50_RS12215	COG1104	cysteine desulfurase activity
BTDUT50_RS12220	COG1959	2 iron, 2 sulfur cluster binding
BTDUT50_RS12225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTDUT50_RS12245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTDUT50_RS12260	COG0124	histidyl-tRNA synthetase
BTDUT50_RS12270	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTDUT50_RS12275	COG1490	D-aminoacyl-tRNA deacylase activity
BTDUT50_RS12280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTDUT50_RS12285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTDUT50_RS12290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BTDUT50_RS12290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTDUT50_RS12295	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BTDUT50_RS12300	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTDUT50_RS12300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTDUT50_RS12310	COG2244	polysaccharide biosynthetic process
BTDUT50_RS12315	COG2323	membrane
BTDUT50_RS12325	COG1862	Preprotein translocase
BTDUT50_RS12330	COG0343	queuine tRNA-ribosyltransferase activity
BTDUT50_RS12335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTDUT50_RS12345	COG2255	four-way junction helicase activity
BTDUT50_RS12350	COG0632	four-way junction helicase activity
BTDUT50_RS12360	COG0217	transcriptional regulatory protein
BTDUT50_RS12370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTDUT50_RS12375	COG1388	LysM domain
BTDUT50_RS12380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BTDUT50_RS12385	COG0157	Belongs to the NadC ModD family
BTDUT50_RS12390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BTDUT50_RS12395	COG1104	cysteine desulfurase activity
BTDUT50_RS12400	COG1827	regulation of RNA biosynthetic process
BTDUT50_RS12405	COG0077	Prephenate dehydratase
BTDUT50_RS12410	COG4492	Belongs to the UPF0735 family
BTDUT50_RS12415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTDUT50_RS12420	COG3290	protein histidine kinase activity
BTDUT50_RS12425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTDUT50_RS12430	COG2868	ribosomal protein
BTDUT50_RS12435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTDUT50_RS12440	COG1994	Peptidase M50
BTDUT50_RS12445	COG0739	heme binding
BTDUT50_RS12450	COG2894	cell division
BTDUT50_RS12455	COG0850	regulation of cytokinetic process
BTDUT50_RS12465	COG1792	Involved in formation and maintenance of cell shape
BTDUT50_RS12470	COG1077	Cell shape determining protein MreB Mrl
BTDUT50_RS12475	COG2003	Belongs to the UPF0758 family
BTDUT50_RS12510	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTDUT50_RS12520	COG1459	type II secretion system
BTDUT50_RS12535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BTDUT50_RS12580	COG0285	dihydrofolate synthase activity
BTDUT50_RS12585	COG0525	valine-tRNA ligase activity
BTDUT50_RS12595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BTDUT50_RS12600	COG1388	LysM domain
BTDUT50_RS12600	COG1388	LysM domain
BTDUT50_RS12605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTDUT50_RS12610	COG0113	porphobilinogen synthase activity
BTDUT50_RS12615	COG1587	Uroporphyrinogen-III synthase
BTDUT50_RS12620	COG0181	hydroxymethylbilane synthase activity
BTDUT50_RS12625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTDUT50_RS12640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTDUT50_RS12655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BTDUT50_RS12660	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTDUT50_RS12670	COG0066	3-isopropylmalate dehydratase activity
BTDUT50_RS12675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTDUT50_RS12680	COG0473	3-isopropylmalate dehydrogenase activity
BTDUT50_RS12685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTDUT50_RS12690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BTDUT50_RS12695	COG0440	acetolactate synthase activity
BTDUT50_RS12700	COG0028	Belongs to the TPP enzyme family
BTDUT50_RS12705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTDUT50_RS12715	COG0622	Phosphoesterase
BTDUT50_RS12720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTDUT50_RS12725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTDUT50_RS12730	COG5401	PFAM Sporulation and spore germination
BTDUT50_RS12735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BTDUT50_RS12740	COG2197	response regulator
BTDUT50_RS12745	COG0824	Thioesterase
BTDUT50_RS12750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTDUT50_RS12755	COG1053	succinate dehydrogenase
BTDUT50_RS12760	COG2009	succinate dehydrogenase
BTDUT50_RS12765	COG1719	4-vinyl reductase, 4VR
BTDUT50_RS12770	COG0322	excinuclease ABC activity
BTDUT50_RS12805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTDUT50_RS12815	COG3118	belongs to the thioredoxin family
BTDUT50_RS12820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BTDUT50_RS12825	COG2086	electron transfer activity
BTDUT50_RS12830	COG1024	Enoyl-CoA hydratase
BTDUT50_RS12835	COG1309	transcriptional regulator
BTDUT50_RS12840	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS12845	COG3766	membrane
BTDUT50_RS12850	COG1193	negative regulation of DNA recombination
BTDUT50_RS12855	COG1796	DNA polymerase
BTDUT50_RS12855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BTDUT50_RS12860	COG1286	toxin biosynthetic process
BTDUT50_RS12865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BTDUT50_RS12880	COG2409	Drug exporters of the RND superfamily
BTDUT50_RS12880	COG1033	growth of symbiont in host cell
BTDUT50_RS12960	COG1196	nuclear chromosome segregation
BTDUT50_RS12970	COG0072	phenylalanine-tRNA ligase activity
BTDUT50_RS12970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTDUT50_RS12975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTDUT50_RS12980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTDUT50_RS12985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTDUT50_RS13005	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTDUT50_RS13010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTDUT50_RS13020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTDUT50_RS13030	COG1484	DNA-dependent DNA replication
BTDUT50_RS13035	COG3611	Membrane attachment protein
BTDUT50_RS13040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTDUT50_RS13050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BTDUT50_RS13055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTDUT50_RS13065	COG1971	Probably functions as a manganese efflux pump
BTDUT50_RS13070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTDUT50_RS13080	COG5002	protein histidine kinase activity
BTDUT50_RS13085	COG0745	RESPONSE REGULATOR receiver
BTDUT50_RS13095	COG0039	L-malate dehydrogenase activity
BTDUT50_RS13100	COG0538	isocitrate dehydrogenase activity
BTDUT50_RS13105	COG0372	Belongs to the citrate synthase family
BTDUT50_RS13110	COG2707	UPF0756 membrane protein
BTDUT50_RS13115	COG0628	permease
BTDUT50_RS13120	COG3030	protein affecting phage T7 exclusion by the F plasmid
BTDUT50_RS13130	COG0205	6-phosphofructokinase activity
BTDUT50_RS13135	COG0825	malonyl-CoA metabolic process
BTDUT50_RS13140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTDUT50_RS13160	COG1725	Transcriptional regulator
BTDUT50_RS13165	COG0281	malic enzyme
BTDUT50_RS13170	COG0587	DNA-directed DNA polymerase activity
BTDUT50_RS13190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BTDUT50_RS13200	COG4109	DRTGG domain
BTDUT50_RS13205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BTDUT50_RS13210	COG0006	proline dipeptidase activity
BTDUT50_RS13215	COG1028	Short-chain dehydrogenase reductase Sdr
BTDUT50_RS13220	COG0589	response to stress
BTDUT50_RS13225	COG0165	Argininosuccinate lyase
BTDUT50_RS13230	COG0137	argininosuccinate synthase activity
BTDUT50_RS13240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTDUT50_RS13245	COG0827	DNA restriction-modification system
BTDUT50_RS13250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BTDUT50_RS13255	COG3874	Sporulation protein YtfJ
BTDUT50_RS13265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTDUT50_RS13300	COG0301	tRNA thio-modification
BTDUT50_RS13305	COG1104	cysteine desulfurase activity
BTDUT50_RS13310	COG1114	Component of the transport system for branched-chain amino acids
BTDUT50_RS13315	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BTDUT50_RS13320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BTDUT50_RS13325	COG1956	GAF domain-containing protein
BTDUT50_RS13330	COG2199	diguanylate cyclase activity
BTDUT50_RS13330	COG2203	Gaf domain
BTDUT50_RS13335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTDUT50_RS13355	COG0454	-acetyltransferase
BTDUT50_RS13360	COG0517	IMP dehydrogenase activity
BTDUT50_RS13365	COG0123	including yeast histone deacetylase and acetoin utilization protein
BTDUT50_RS13375	COG1605	Chorismate mutase
BTDUT50_RS13375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BTDUT50_RS13385	COG2309	aminopeptidase activity
BTDUT50_RS13390	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BTDUT50_RS13400	COG3118	belongs to the thioredoxin family
BTDUT50_RS13405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTDUT50_RS13415	COG1674	ftsk spoiiie
BTDUT50_RS13415	COG1674	ftsk spoiiie
BTDUT50_RS13420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTDUT50_RS13425	COG4848	Belongs to the UPF0354 family
BTDUT50_RS13430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTDUT50_RS13435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BTDUT50_RS13440	COG1363	Peptidase, m42
BTDUT50_RS13450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTDUT50_RS13455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTDUT50_RS13465	COG0510	thiamine kinase activity
BTDUT50_RS13470	COG1523	belongs to the glycosyl hydrolase 13 family
BTDUT50_RS13480	COG1346	cytolysis
BTDUT50_RS13485	COG1380	Effector of murein hydrolase LrgA
BTDUT50_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTDUT50_RS13505	COG1349	DNA-binding transcription factor activity
BTDUT50_RS13510	COG1187	pseudouridine synthase activity
BTDUT50_RS13520	COG2244	polysaccharide biosynthetic process
BTDUT50_RS13530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BTDUT50_RS13535	COG0495	leucyl-tRNA aminoacylation
BTDUT50_RS13560	COG1242	4 iron, 4 sulfur cluster binding
BTDUT50_RS13565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BTDUT50_RS13580	COG2267	carboxylic ester hydrolase activity
BTDUT50_RS13585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BTDUT50_RS13590	COG0671	phosphoesterase, PA-phosphatase related
BTDUT50_RS13595	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTDUT50_RS13600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BTDUT50_RS13620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTDUT50_RS13625	COG1116	anion transmembrane transporter activity
BTDUT50_RS13630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTDUT50_RS13635	COG0494	nUDIX hydrolase
BTDUT50_RS13645	COG0783	Belongs to the Dps family
BTDUT50_RS13650	COG1854	S-ribosylhomocysteine lyase activity
BTDUT50_RS13655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTDUT50_RS13665	COG3443	Belongs to the bacterial solute-binding protein 9 family
BTDUT50_RS13665	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTDUT50_RS13670	COG1271	oxidase subunit
BTDUT50_RS13675	COG1294	oxidase, subunit
BTDUT50_RS13680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTDUT50_RS13685	COG0716	FMN binding
BTDUT50_RS13690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BTDUT50_RS13710	COG1271	oxidase subunit
BTDUT50_RS13715	COG1294	oxidase, subunit
BTDUT50_RS13720	COG0318	PFAM AMP-dependent synthetase and ligase
BTDUT50_RS13725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTDUT50_RS13730	COG0596	Alpha beta hydrolase
BTDUT50_RS13735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BTDUT50_RS13740	COG1575	Belongs to the MenA family. Type 1 subfamily
BTDUT50_RS13745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BTDUT50_RS13750	COG0058	SHG alpha-glucan phosphorylase activity
BTDUT50_RS13755	COG0297	glycogen (starch) synthase activity
BTDUT50_RS13760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BTDUT50_RS13850	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTDUT50_RS13925	COG0735	belongs to the Fur family
BTDUT50_RS13930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTDUT50_RS13950	COG4555	ABC transporter
BTDUT50_RS13955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTDUT50_RS13960	COG0070	glutamate synthase
BTDUT50_RS13960	COG0067	glutamate synthase
BTDUT50_RS13960	COG0069	glutamate synthase activity
BTDUT50_RS13970	COG4129	membrane
BTDUT50_RS13975	COG3557	Belongs to the UPF0374 family
BTDUT50_RS13995	COG1988	membrane-bound metal-dependent
BTDUT50_RS14015	COG1620	l-lactate permease
BTDUT50_RS14020	COG4221	oxidoreductase activity
BTDUT50_RS14025	COG2137	regulation of response to DNA damage stimulus
BTDUT50_RS14030	COG1090	epimerase
BTDUT50_RS14070	COG0840	transmembrane signaling receptor activity
BTDUT50_RS14080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTDUT50_RS14100	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BTDUT50_RS14105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BTDUT50_RS14115	COG1733	regulation of RNA biosynthetic process
BTDUT50_RS14125	COG3153	acetyltransferase
BTDUT50_RS14125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTDUT50_RS14130	COG0456	acetyltransferase
BTDUT50_RS14140	COG0693	protein deglycase activity
BTDUT50_RS14145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BTDUT50_RS14150	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BTDUT50_RS14175	COG0501	Belongs to the peptidase M48B family
BTDUT50_RS14230	COG1595	DNA-templated transcription, initiation
BTDUT50_RS14250	COG2801	Transposase and inactivated derivatives
BTDUT50_RS14265	COG0604	alcohol dehydrogenase
BTDUT50_RS14280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTDUT50_RS14295	COG1473	amidohydrolase
BTDUT50_RS14300	COG1757	Na H antiporter
BTDUT50_RS14315	COG3654	unkown
BTDUT50_RS14350	COG0385	Bile acid
BTDUT50_RS14360	COG1247	-acetyltransferase
BTDUT50_RS14365	COG0494	nUDIX hydrolase
BTDUT50_RS14380	COG0840	transmembrane signaling receptor activity
BTDUT50_RS14385	COG1966	Carbon starvation protein
BTDUT50_RS14390	COG3279	Response regulator of the LytR AlgR family
BTDUT50_RS14395	COG3275	phosphorelay sensor kinase activity
BTDUT50_RS14415	COG3654	unkown
BTDUT50_RS14455	COG3335	DDE superfamily endonuclease
BTDUT50_RS14465	COG2801	Transposase and inactivated derivatives
BTDUT50_RS14475	COG2358	TRAP transporter, solute receptor (TAXI family
BTDUT50_RS14480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTDUT50_RS14505	COG3885	ferrous iron binding
BTDUT50_RS14505	COG2078	PFAM AMMECR1 domain protein
BTDUT50_RS14530	COG3971	2-oxopent-4-enoate hydratase activity
BTDUT50_RS14555	COG3335	DDE superfamily endonuclease
BTDUT50_RS14565	COG1587	Uroporphyrinogen-III synthase
BTDUT50_RS14565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTDUT50_RS14570	COG2146	nitrite reductase [NAD(P)H] activity
BTDUT50_RS14575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BTDUT50_RS14580	COG2258	MOSC domain
BTDUT50_RS14585	COG0674	pyruvate-flavodoxin oxidoreductase activity
BTDUT50_RS14590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BTDUT50_RS14610	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTDUT50_RS14610	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTDUT50_RS14635	COG2608	mercury ion transmembrane transporter activity
BTDUT50_RS14665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTDUT50_RS14670	COG2011	ABC-type metal ion transport system permease component
BTDUT50_RS14680	COG0371	Dehydrogenase
BTDUT50_RS14695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BTDUT50_RS14785	COG1040	competence protein
BTDUT50_RS14905	COG0535	radical SAM domain protein
BTDUT50_RS14915	COG0477	Major facilitator Superfamily
BTDUT50_RS14925	COG1295	ribonuclease BN
BTDUT50_RS14935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTDUT50_RS14945	COG4840	Belongs to the UPF0435 family
BTDUT50_RS14955	COG0175	sulfate reduction
BTDUT50_RS14960	COG0306	phosphate transporter
BTDUT50_RS14965	COG2046	Belongs to the sulfate adenylyltransferase family
BTDUT50_RS14970	COG0529	Catalyzes the synthesis of activated sulfate
BTDUT50_RS14985	COG1648	precorrin-2 dehydrogenase activity