locus-tag class description B4918_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_RS00015 ENOG410848D S4 domain protein YaaA B4918_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B4918_RS00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B4918_RS00100 ENOG4105ZMH deoxynucleoside kinase B4918_RS00110 ENOG4105GTG Isochorismatase B4918_RS00120 ENOG4108Z6B deaminase B4918_RS00130 ENOG4105C6E dna polymerase iii B4918_RS00150 ENOG41067KS pro-sigma K processing B4918_RS00185 ENOG4105CXN decarboxylase B4918_RS00195 ENOG4105FA2 dna polymerase iii B4918_RS00200 ENOG4105MA4 psp1 domain protein B4918_RS00210 ENOG41060K3 Methyltransferase B4918_RS00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B4918_RS00225 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B4918_RS00235 ENOG4105F8V Hydrolase, tatD family B4918_RS00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) B4918_RS00250 ENOG4105XFA sporulation peptidase YabG B4918_RS00255 ENOG4105W42 Veg protein B4918_RS00270 ENOG4105DFT pur operon repressor B4918_RS00280 ENOG4105KME endoribonuclease L-psp B4918_RS00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B4918_RS00300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) B4918_RS00310 ENOG4108JA2 transcriptioN-repair coupling factor B4918_RS00315 ENOG4108M14 stage v sporulation protein t B4918_RS00325 ENOG4108IY2 MazG family B4918_RS00330 ENOG41082I2 s4 domain protein B4918_RS00335 ENOG4105VYY sporulation protein yabp B4918_RS00350 ENOG41060GV RNA binding s1 domain protein B4918_RS00370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B4918_RS00375 ENOG4108UGV hypoxanthine phosphoribosyltransferase B4918_RS00380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B4918_RS00395 ENOG4105C6T cysteine synthase B4918_RS00400 ENOG4105CRQ synthase (Component I) B4918_RS00405 ENOG4105DDQ anthranilate synthase B4918_RS00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B4918_RS00415 ENOG4105EEI dihydropteroate synthase B4918_RS00420 ENOG4105KRF dihydroneopterin aldolase B4918_RS00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B4918_RS00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B4918_RS00525 ENOG4108Z0C Uvrb UvrC protein B4918_RS00540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B4918_RS00550 ENOG4105CTP PilT protein domain protein B4918_RS00570 ENOG4105D7W serine acetyltransferase B4918_RS00585 ENOG4105C2N RNA methyltransferase TrmH family group 3 B4918_RS00590 ENOG4105M0M Tetracycline resistance protein B4918_RS00595 ENOG4105QIV RNA polymerase B4918_RS00610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B4918_RS00635 ENOG4107Y49 methyltransferase B4918_RS00645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B4918_RS00650 ENOG4105XPM ribosomal protein B4918_RS00760 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B4918_RS00785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B4918_RS00795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B4918_RS00805 ENOG41067V7 50S ribosomal protein L36 B4918_RS00830 ENOG4108JJB ABC transporter B4918_RS00835 ENOG4108JJB ABC transporter B4918_RS00840 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B4918_RS00845 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B4918_RS00870 ENOG4105D1F ATP-binding protein B4918_RS00885 ENOG4108NMV polysaccharide deacetylase B4918_RS00975 ENOG4105C8B TIGR00159 family B4918_RS00980 ENOG4107U5W ybbr family B4918_RS00995 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B4918_RS01015 ENOG4108PSK reductase B4918_RS01020 ENOG4108UMI ABC transporter, permease B4918_RS01025 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS01030 ENOG4105D01 (LipO)protein B4918_RS01035 ENOG4105CB2 alcohol dehydrogenase B4918_RS01045 ENOG4105IQ5 FAD linked oxidase domain protein B4918_RS01060 ENOG4105C2C drug resistance transporter, Bcr CflA B4918_RS01080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_RS01085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_RS01090 ENOG4105C3U ABC transporter B4918_RS01095 ENOG4108JQ7 (ABC) transporter B4918_RS01120 ENOG4108J59 Extracellular solute-binding protein, family 5 B4918_RS01140 ENOG4105E0C molybdate abc transporter B4918_RS01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B4918_RS01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family B4918_RS01185 ENOG4105F6E Acyl-transferase B4918_RS01215 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS01240 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B4918_RS01265 ENOG4105C5H ABC transporter B4918_RS01280 ENOG4105DEF Extracellular solute-binding protein, family 5 B4918_RS01290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_RS01295 ENOG4105C3U ABC transporter B4918_RS01300 ENOG4108JQ7 (ABC) transporter B4918_RS01305 ENOG410667J hydrolase B4918_RS01335 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase B4918_RS01340 ENOG4105ERH Fumarylacetoacetate hydrolase B4918_RS01350 ENOG4105CUB amino acid B4918_RS01355 ENOG4108SC4 )-transporter B4918_RS01360 ENOG4105CPF Cell wall formation (By similarity) B4918_RS01365 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B4918_RS01390 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B4918_RS01395 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B4918_RS01405 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B4918_RS01510 ENOG4105K8N protein family UPF0079, ATPase B4918_RS01515 ENOG41072GX Peptidase M22 Glycoprotease B4918_RS01520 ENOG410801F ribosomal-protein-alanine acetyltransferase B4918_RS01525 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B4918_RS01535 ENOG4105C5H ABC transporter B4918_RS01550 ENOG4108TYN CAAX amino terminal protease family protein B4918_RS01570 ENOG4105C7N Xanthine uracil vitamin C permease B4918_RS01580 ENOG4105BZU Histidine kinase B4918_RS01610 ENOG4107ZXU DSBA oxidoreductase B4918_RS01630 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_RS01655 ENOG410631K Membrane B4918_RS01685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B4918_RS01690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B4918_RS01695 ENOG4105C83 adenylosuccinate lyase B4918_RS01705 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B4918_RS01730 ENOG4108V3E phosphoribosylglycinamide formyltransferase B4918_RS01740 ENOG4105C12 Phosphoribosylglycinamide synthetase B4918_RS01765 ENOG4105C4R Atp-dependent dna helicase B4918_RS01790 ENOG4108W2Y isochorismatase B4918_RS01795 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS01800 ENOG4108UMI ABC transporter, permease B4918_RS01805 ENOG4105D01 (LipO)protein B4918_RS01810 ENOG4107I77 yiaA/B two helix domain B4918_RS01830 ENOG4105CBD Diacylglycerol kinase B4918_RS01840 ENOG4108JPW Aminotransferase B4918_RS01850 ENOG4105C26 Dehydrogenase B4918_RS01855 ENOG4105KPY Small multidrug resistance protein B4918_RS01880 ENOG4105D9N nucleoside B4918_RS01885 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B4918_RS01895 ENOG4108W15 Protein of unknown function (DUF1456) B4918_RS01915 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_RS01925 ENOG4105DFD Na H antiporter B4918_RS01945 ENOG4105D3R alkyl hydroperoxide reductase B4918_RS01950 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) B4918_RS01955 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B4918_RS01960 ENOG4107W7X Aldolase B4918_RS01965 ENOG4105EHG Permease protein B4918_RS01970 ENOG4105DQ5 transport system permease protein B4918_RS01975 ENOG4108V5C ABC transporter B4918_RS02005 ENOG4106UIA B4918_RS02010 ENOG4106UIA B4918_RS02030 ENOG4105BZU Histidine kinase B4918_RS02050 ENOG410756H nucleotidyltransferase B4918_RS02055 ENOG4105D2S major facilitator superfamily B4918_RS02070 ENOG4105E5Q amino acid AbC transporter B4918_RS02075 ENOG4105EAB amino acid AbC transporter B4918_RS02080 ENOG4105CDA abc transporter atp-binding protein B4918_RS02085 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS02100 ENOG4105DBV ornithine carbamoyltransferase B4918_RS02110 ENOG4105C5B carbamate kinase B4918_RS02115 ENOG4108W63 CRP FNR family transcriptional regulator B4918_RS02125 ENOG4105DNP FAD linked oxidase domain protein B4918_RS02135 ENOG4105CI1 PTS System B4918_RS02150 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_RS02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter B4918_RS02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B4918_RS02190 ENOG4105D2X ABC transporter substrate-binding protein B4918_RS02200 ENOG4105C5H ABC transporter B4918_RS02235 ENOG41062JF Transcriptional regulator B4918_RS02250 ENOG4105DEU major facilitator superfamily B4918_RS02280 ENOG4108N0M stress protein B4918_RS02285 ENOG4106FN3 tellurium resistance protein B4918_RS02290 ENOG4106FN3 tellurium resistance protein B4918_RS02295 ENOG4107TS3 membrane protein, TerC B4918_RS02300 ENOG4108TTB tellurium resistance protein B4918_RS02315 ENOG41068PA UPF0435 protein B4918_RS02320 ENOG4105KJF protein tyrosine phosphatase B4918_RS02330 ENOG4107U9T Pfam:Ribonuclease_BN B4918_RS02340 ENOG4105C59 p-type ATPase B4918_RS02345 ENOG4108IPJ Membrane B4918_RS02365 ENOG4107ZTW SNARE associated Golgi B4918_RS02385 ENOG4105UPD Calcium Proton B4918_RS02420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B4918_RS02435 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B4918_RS02445 ENOG4108JUB Transcriptional regulator B4918_RS02455 ENOG4108IQI permease B4918_RS02490 ENOG4105CSV Glutaminase B4918_RS02510 ENOG4108A04 Beta-lactamase B4918_RS02525 ENOG4107R51 Glycosyl transferase, family 2 B4918_RS02530 ENOG4107QQG Dehydrogenase B4918_RS02535 ENOG4105C3I Nad-dependent epimerase dehydratase B4918_RS02540 ENOG4105CKK Glycosyl transferase, family 2 B4918_RS02555 ENOG4105F1A Pyruvate formate-lyase B4918_RS02575 ENOG4105CI2 imidazolone-5-propionate hydrolase B4918_RS02580 ENOG4105ECP epimerase B4918_RS02610 ENOG41067AE Membrane-bound metal-dependent hydrolase B4918_RS02615 ENOG4105CEN a g-specific adenine glycosylase B4918_RS02620 ENOG4106BXE B4918_RS02640 ENOG4105BZ1 (ABC) transporter B4918_RS02645 ENOG4107NBY Membrane B4918_RS02650 ENOG4105CBC glutamate synthase B4918_RS02660 ENOG4108IUW ABC transporter B4918_RS02680 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_RS02685 ENOG4105G5W regulator Fur family B4918_RS02840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS02875 ENOG4108JQC penicillin-binding protein 1A B4918_RS02880 ENOG4108R9S DSBA oxidoreductase B4918_RS02890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B4918_RS02900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B4918_RS02905 ENOG4105BZU Histidine kinase B4918_RS02915 ENOG4105CYN Serine protein kinase B4918_RS02935 ENOG4105C94 Transporter B4918_RS02950 ENOG4105DZ6 Band 7 protein B4918_RS02960 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B4918_RS02965 ENOG4108V9W transcriptional regulatory protein B4918_RS02970 ENOG4105D4T Citrate transporter B4918_RS02995 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B4918_RS03000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS03005 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B4918_RS03010 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component B4918_RS03015 ENOG4105BZ7 extracellular solute-binding protein family 1 B4918_RS03020 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) B4918_RS03025 ENOG4108STX response regulator B4918_RS03030 ENOG4105US7 Histidine kinase B4918_RS03055 ENOG4108MRH transcriptional regulatory protein B4918_RS03065 ENOG4105C6K Malic enzyme B4918_RS03075 ENOG4108UZ3 Transporter B4918_RS03080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_RS03090 ENOG4105BZU Histidine kinase B4918_RS03120 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B4918_RS03125 ENOG4108JB9 formate dehydrogenase B4918_RS03145 ENOG4105CUB amino acid B4918_RS03155 ENOG4105C59 p-type ATPase B4918_RS03160 ENOG4105DAP Nicotinate phosphoribosyltransferase B4918_RS03195 ENOG41073R8 VanW family B4918_RS03200 ENOG4108KGH TRANSCRIPTIONal B4918_RS03205 ENOG4105D9N nucleoside B4918_RS03210 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B4918_RS03215 ENOG41085W3 Transposase B4918_RS03225 ENOG4105C37 (CBS) domain B4918_RS03230 ENOG4108IJ0 Aspartate ammonia-lyase B4918_RS03235 ENOG4105DAA L-lactate B4918_RS03250 ENOG4105DUX Transporter B4918_RS03255 ENOG4108MES Periplasmic binding protein B4918_RS03260 ENOG4105DQ5 transport system permease protein B4918_RS03265 ENOG4108IHU transport system permease protein B4918_RS03270 ENOG4105E0A ABC, transporter B4918_RS03285 ENOG4105EXW epimerase dehydratase B4918_RS03295 ENOG4107T89 von Willebrand factor, type A B4918_RS03300 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B4918_RS03305 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_RS03315 ENOG4105BZU Histidine kinase B4918_RS03320 ENOG4105D5Q Arginine ornithine antiporter B4918_RS03325 ENOG4107414 GntR family transcriptional regulator B4918_RS03330 ENOG4105C5Y PTS System B4918_RS03335 ENOG4105CG3 alpha amylase, catalytic region B4918_RS03350 ENOG4105E1K spore germination protein B4918_RS03355 ENOG4105CRN Aminoglycoside phosphotransferase B4918_RS03360 ENOG4105BZG amino acid carrier protein B4918_RS03370 ENOG4105CDA abc transporter atp-binding protein B4918_RS03375 ENOG4105CT1 (ABC) transporter B4918_RS03380 ENOG4105EAD ABC transporter B4918_RS03385 ENOG4105DRP amino acid AbC transporter B4918_RS03390 ENOG4108IQI permease B4918_RS03405 ENOG4105GFR rna polymerase sigma factor B4918_RS03415 ENOG4105D29 Helix-turn-helix type 11 domain protein B4918_RS03420 ENOG4105NAE bifunctional deaminase-reductase domain protein B4918_RS03425 ENOG4105BZU Histidine kinase B4918_RS03440 ENOG4105CHH sulfate transporter B4918_RS03445 ENOG41068KF Universal stress protein B4918_RS03455 ENOG4105CXY transporter B4918_RS03460 ENOG41067TZ transcriptional regulator, MarR family B4918_RS03465 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_RS03470 ENOG4105ETE Transcriptional regulator (LacI family B4918_RS03475 ENOG4108RVA ribokinase B4918_RS03485 ENOG4105C2J ABC transporter B4918_RS03490 ENOG4105CNN ABC, transporter B4918_RS03495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B4918_RS03500 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B4918_RS03540 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) B4918_RS03570 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_RS03575 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B4918_RS03580 ENOG41069ER domain protein B4918_RS03585 ENOG4105VZ8 Transcriptional regulator B4918_RS03590 ENOG4107D63 B4918_RS03605 ENOG4105DUX Transporter B4918_RS03625 ENOG4105C85 amino acid B4918_RS03630 ENOG4105C7N Xanthine uracil vitamin C permease B4918_RS03645 ENOG4105MA6 gCN5-related N-acetyltransferase B4918_RS03670 ENOG4105BZ9 Cytochrome C oxidase, subunit I B4918_RS03675 ENOG4105E2S oxidase) subunit II B4918_RS03695 ENOG4106CAD Protein of unknown function (DUF3311) B4918_RS03700 ENOG4105E1V na solute symporter B4918_RS03715 ENOG4108NHD germination protein B4918_RS03725 ENOG4105CE1 Ferrous iron transport protein b B4918_RS03730 ENOG4105CE1 Ferrous iron transport protein b B4918_RS03735 ENOG4105CE1 Ferrous iron transport protein b B4918_RS03740 ENOG4105CVA phosphate B4918_RS03745 ENOG4105C8U phosphate abc transporter B4918_RS03750 ENOG4105E2Z phosphate ABC transporter (Permease B4918_RS03880 ENOG41080XQ Signal transduction protein with cbs domains B4918_RS03905 ENOG4105ETU transcriptional activator (TenA B4918_RS03915 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B4918_RS03925 ENOG4108VEU Thiamine monophosphate synthase B4918_RS03930 ENOG41080HI glycine oxidase B4918_RS03945 ENOG4105D06 uba thif-type nad fad binding protein B4918_RS03950 ENOG4105DWF phosphomethylpyrimidine kinase B4918_RS03985 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) B4918_RS04000 ENOG4108INS Transcriptional regulator B4918_RS04025 ENOG4105C19 ABC transporter B4918_RS04035 ENOG4105C7N Xanthine uracil vitamin C permease B4918_RS04045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B4918_RS04060 ENOG4105K63 Thioredoxin B4918_RS04080 ENOG4108B31 Spore germination protein B4918_RS04100 ENOG4107Y03 Nitroreductase B4918_RS04105 ENOG4105ED1 spovr family B4918_RS04125 ENOG4105XTG Pfam:DUF156 B4918_RS04130 ENOG4105VFE sira family B4918_RS04135 ENOG4107TPS domain protein B4918_RS04140 ENOG4105VFE sira family B4918_RS04145 ENOG4105VFE sira family B4918_RS04150 ENOG41085GJ domain protein B4918_RS04155 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B4918_RS04160 ENOG41087NI Sulfite exporter TauE/SafE B4918_RS04170 ENOG4108KGH TRANSCRIPTIONal B4918_RS04195 ENOG4105EMD TRANSCRIPTIONal B4918_RS04200 ENOG4105VCP PTS System B4918_RS04205 ENOG4105VZJ PTS System B4918_RS04230 ENOG41069ER domain protein B4918_RS04235 ENOG4107RBB ABC transporter, permease B4918_RS04240 ENOG4105C19 ABC transporter B4918_RS04270 ENOG4105WEF catalase B4918_RS04305 ENOG4107T5V SNARE associated Golgi B4918_RS04340 ENOG4105CUB amino acid B4918_RS04345 ENOG4107RWR Sodium hydrogen exchanger B4918_RS04355 ENOG4106KNT transcriptional regulator B4918_RS04395 ENOG4108YXU transcriptional regulator AsnC family B4918_RS04405 ENOG4105UBK short-chain dehydrogenase reductase B4918_RS04410 ENOG4105W1Y Transcriptional regulator B4918_RS04415 ENOG4105KPY Small multidrug resistance protein B4918_RS04445 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF B4918_RS04455 ENOG4107RKG DJ-1/PfpI family B4918_RS04460 ENOG4105CH6 catalase B4918_RS04470 ENOG4105D5Q Arginine ornithine antiporter B4918_RS04475 ENOG4105C26 Dehydrogenase B4918_RS04490 ENOG4105BZ1 (ABC) transporter B4918_RS04495 ENOG4105BZ1 (ABC) transporter B4918_RS04510 ENOG4105DRP amino acid AbC transporter B4918_RS04515 ENOG4105CDA abc transporter atp-binding protein B4918_RS04530 ENOG410839P B4918_RS04565 ENOG4107FQX Alpha-acetolactate decarboxylase B4918_RS04590 ENOG4105D4P Coproporphyrinogen iii oxidase B4918_RS04595 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS04605 ENOG4105CHH sulfate transporter B4918_RS04630 ENOG4105CGU Enoyl-CoA hydratase B4918_RS04650 ENOG4105DER m42 family B4918_RS04670 ENOG4105CTU Proline racemase B4918_RS04675 ENOG4105CIF Ornithine Cyclodeaminase B4918_RS04690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_RS04700 ENOG4108JQ7 (ABC) transporter B4918_RS04750 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase B4918_RS04765 ENOG4105D06 uba thif-type nad fad binding protein B4918_RS04770 ENOG4107SFI Major Facilitator superfamily B4918_RS04810 ENOG4105CSH Transporter B4918_RS04820 ENOG4108MRH transcriptional regulatory protein B4918_RS04860 ENOG4105CVR type I restriction-modification system B4918_RS04865 ENOG4107XZC Restriction modification system DNA (Specificity B4918_RS04870 ENOG4105DZR Type I site-specific deoxyribonuclease B4918_RS04880 ENOG4105C4R Atp-dependent dna helicase B4918_RS04885 ENOG4105C4R Atp-dependent dna helicase B4918_RS04905 ENOG4105EB3 Histidine kinase B4918_RS04920 ENOG4105DVF Cytosine-specific methyltransferase B4918_RS04930 ENOG4105CDU Replicative dna helicase B4918_RS04960 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_RS04980 ENOG4105D9U N-acetyltransferase B4918_RS05030 ENOG4105F6J Alpha beta hydrolase fold B4918_RS05100 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B4918_RS05110 ENOG4105F27 Major Facilitator B4918_RS05115 ENOG4105WAB arsR family transcriptional regulator B4918_RS05130 ENOG4105CMT Dihydroxyacetone kinase B4918_RS05140 ENOG4105CMT Dihydroxyacetone kinase B4918_RS05245 ENOG4105WN5 stage II sporulation protein B4918_RS05255 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS05265 ENOG4108MJI response regulator B4918_RS05270 ENOG4105BZU Histidine kinase B4918_RS05275 ENOG4105BZU Histidine kinase B4918_RS05310 ENOG4105D7V transposase B4918_RS05320 ENOG4107QHE Choloylglycine hydrolase B4918_RS05340 ENOG4107VRP DNA repair exonuclease B4918_RS05345 ENOG4106D4I domain protein B4918_RS05365 ENOG410829K Lysine exporter protein (Lyse ygga) B4918_RS05390 ENOG4108MUZ hydrolase B4918_RS05405 ENOG4105F0F Oxalate decarboxylase B4918_RS05410 ENOG41067QW Transcriptional regulator B4918_RS05415 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B4918_RS05430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B4918_RS05440 ENOG4105EMN RNA polymerase sigma factor B4918_RS05455 ENOG4105EEM helicase B4918_RS05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_RS05490 ENOG4105K59 histidine triad (HIT) protein B4918_RS05525 ENOG410905X membrane-flanked domain protein B4918_RS05530 ENOG4105CKV Membrane B4918_RS05570 ENOG410905X membrane-flanked domain protein B4918_RS05575 ENOG4105CKV Membrane B4918_RS05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B4918_RS05585 ENOG4105BZ4 penicillin-binding protein B4918_RS05595 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B4918_RS05600 ENOG4105C1Q protoporphyrinogen oxidase B4918_RS05630 ENOG4105ECB domain protein B4918_RS05660 ENOG4106AXD B4918_RS05665 ENOG4108RQ5 Beta-lactamase domain-containing protein B4918_RS05670 ENOG4105DF9 Lipoate-protein, ligase B4918_RS05680 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS05710 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) B4918_RS05720 ENOG4105ENX hydrolase B4918_RS05725 ENOG4107RN3 metallophosphoesterase B4918_RS05730 ENOG4107TVP HD domain protein B4918_RS05745 ENOG4108AEY RNA polymerase sigma factor B4918_RS05750 ENOG41086D8 Transcriptional regulator B4918_RS05770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_RS05790 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B4918_RS05795 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS05805 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) B4918_RS05815 ENOG4107QP3 malate synthase g B4918_RS05835 ENOG4105VEQ Cold shock protein B4918_RS05850 ENOG4105XVF Competence transcription factor B4918_RS05915 ENOG4105ERH Fumarylacetoacetate hydrolase B4918_RS05925 ENOG4105C8Y Acetylornithine aminotransferase B4918_RS05940 ENOG4105CAQ asparagine synthetase B4918_RS05955 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B4918_RS06160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS06190 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B4918_RS06195 ENOG4105CH6 catalase B4918_RS06200 ENOG4105BZU Histidine kinase B4918_RS06220 ENOG4105QNR S1 RNA binding domain protein B4918_RS06225 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_RS06235 ENOG4107AYK membrAne B4918_RS06240 ENOG41073B9 B4918_RS06250 ENOG4108KP7 hydrolase B4918_RS06265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B4918_RS06290 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B4918_RS06295 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B4918_RS06315 ENOG4105C31 Tryptophanyl-tRNA synthetase B4918_RS06335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_RS06340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_RS06350 ENOG4108JQ7 (ABC) transporter B4918_RS06355 ENOG4105UQX Mate efflux family protein B4918_RS06385 ENOG4108ZCF integral membrane protein B4918_RS06395 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_RS06405 ENOG4105DPN Oligoendopeptidase f B4918_RS06420 ENOG4108Z18 K06886 hemoglobin B4918_RS06425 ENOG4105MIX Adenylate cyclase B4918_RS06440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B4918_RS06445 ENOG4105EMS pseudouridine synthase B4918_RS06465 ENOG4105K64 Glycosyl transferase, family 2 B4918_RS06485 ENOG4107TVC Glycosyl transferase, family 2 B4918_RS06505 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B4918_RS06510 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B4918_RS06520 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B4918_RS06595 ENOG4105CK7 Sodium proline symporter B4918_RS06605 ENOG4105CRQ synthase (Component I) B4918_RS06610 ENOG4105DDQ anthranilate synthase B4918_RS06715 ENOG4105C7S Dehydrogenase B4918_RS06720 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B4918_RS06725 ENOG4105VZ8 Transcriptional regulator B4918_RS06770 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B4918_RS06780 ENOG4105DZ1 carboxypeptidase B4918_RS06785 ENOG4105VFR signal peptidase B4918_RS06815 ENOG4105C26 Dehydrogenase B4918_RS06820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS06825 ENOG4105F38 ABC transporter, permease B4918_RS06830 ENOG4105D38 putrescine abc transporter B4918_RS06835 ENOG4107RUE extracellular solute-binding protein family 1 B4918_RS06840 ENOG410841Q phosphoesterase PA-phosphatase related protein B4918_RS06845 ENOG4105EYF MMPL domain protein B4918_RS06855 ENOG4108YBP pseudouridine synthase B4918_RS06865 ENOG4105K4I Scp-like extracellular B4918_RS06870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B4918_RS06875 ENOG4105CQB FAD linked oxidase domain protein B4918_RS06890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS06895 ENOG4105BZU Histidine kinase B4918_RS06900 ENOG4105JXH GntR family transcriptional regulator B4918_RS06920 ENOG4106A3R peptidase B4918_RS06930 ENOG4108QTI )-transporter B4918_RS06935 ENOG4107TS3 membrane protein, TerC B4918_RS06940 ENOG4105CZN Potassium uptake protein B4918_RS06945 ENOG410681C small acid-soluble spore protein B4918_RS06950 ENOG4108Z7G MaoC domain protein dehydratase B4918_RS06970 ENOG4105CHR reductase B4918_RS07005 ENOG4105C4Y ABC transporter B4918_RS07010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS07015 ENOG4107RCV ABC transporter, permease B4918_RS07035 ENOG4105E98 transcriptional regulator DeoR family B4918_RS07050 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B4918_RS07060 ENOG4105PXI polysaccharide deacetylase B4918_RS07070 ENOG4105BZU Histidine kinase B4918_RS07075 ENOG41090MY MarR family Transcriptional regulator B4918_RS07085 ENOG4106DF1 B4918_RS07095 ENOG4105BZU Histidine kinase B4918_RS07105 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase B4918_RS07110 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B4918_RS07160 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B4918_RS07165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B4918_RS07170 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B4918_RS07175 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B4918_RS07180 ENOG4105CZV ABC transporter B4918_RS07190 ENOG4105CJ1 ABC, transporter B4918_RS07230 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B4918_RS07235 ENOG4105EA8 2-Nitropropane dioxygenase B4918_RS07240 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B4918_RS07250 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B4918_RS07275 ENOG4105NQC Flavodoxin B4918_RS07320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_RS07350 ENOG4105CZN Potassium uptake protein B4918_RS07355 ENOG41063Y9 B4918_RS07360 ENOG4105KBJ sporulation protein ytfj B4918_RS07390 ENOG4105CM2 brancheD-chain amino acid aminotransferase B4918_RS07395 ENOG4105C7K acetolactate synthase B4918_RS07400 ENOG4108ZP8 Acetolactate synthase small subunit B4918_RS07405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B4918_RS07440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B4918_RS07475 ENOG4107RVV histidinol phosphate phosphatase, hisj family B4918_RS07490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B4918_RS07495 ENOG4105E0M Sulfatase B4918_RS07500 ENOG4105VTR Integrase B4918_RS07515 ENOG4108IMY Transcriptional regulator B4918_RS07525 ENOG4108ZUE Phage regulatory protein rha B4918_RS07570 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS07710 ENOG4105CAR Terminase, large subunit B4918_RS07720 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_RS07790 ENOG4105XSJ toxin secretion phage lysis holin B4918_RS07795 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_RS07815 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B4918_RS07835 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) B4918_RS07840 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B4918_RS07850 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B4918_RS07855 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B4918_RS07860 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B4918_RS07870 ENOG4105C8J )-transporter B4918_RS07890 ENOG4105DFD Na H antiporter B4918_RS07910 ENOG4105ENE Histidine kinase B4918_RS07915 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_RS07935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B4918_RS07960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B4918_RS07985 ENOG4105CJ3 phosphate transporter B4918_RS07990 ENOG4107GRR phosphate transport regulator B4918_RS07995 ENOG4105BZ4 penicillin-binding protein B4918_RS08010 ENOG4105BZU Histidine kinase B4918_RS08015 ENOG4105I3N Conserved Protein B4918_RS08030 ENOG4105BZU Histidine kinase B4918_RS08060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_RS08065 ENOG4105DZ1 carboxypeptidase B4918_RS08070 ENOG4108JIC nucleoside recognition domain protein B4918_RS08080 ENOG4105FE9 pseudouridine synthase B4918_RS08085 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_RS08090 ENOG4107TWT Cytochrome c biogenesis protein B4918_RS08095 ENOG4105CRE cytochrome C B4918_RS08100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS08105 ENOG4105BZU Histidine kinase B4918_RS08110 ENOG4108WBT adenosyltransferase B4918_RS08125 ENOG4108SAX Membrane B4918_RS08140 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_RS08145 ENOG4105I7S Abortive infection protein B4918_RS08155 ENOG4107RGJ metallophosphoesterase B4918_RS08160 ENOG4108XDN Transcriptional regulator B4918_RS08165 ENOG4108S6Z Negative regulator of genetic competence B4918_RS08190 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B4918_RS08195 ENOG4107RB3 L-asparaginase B4918_RS08230 ENOG4105S2F B4918_RS08235 ENOG41065D1 B4918_RS08265 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B4918_RS08280 ENOG4105XXQ heptaprenyl diphosphate synthase component I B4918_RS08290 ENOG4105EAH synthase B4918_RS08295 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B4918_RS08300 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B4918_RS08320 ENOG41068YB TPR repeat-containing protein B4918_RS08335 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) B4918_RS08340 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B4918_RS08375 ENOG4108JYZ YitT family B4918_RS08380 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B4918_RS08395 ENOG4105FJR Lmbe family B4918_RS08400 ENOG4105CPK Glycosyl transferase (Group 1 B4918_RS08440 ENOG4105DVT helicase B4918_RS08445 ENOG4105YAC B4918_RS08465 ENOG4105CSM endonuclease III B4918_RS08475 ENOG4105BZ4 penicillin-binding protein B4918_RS08535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B4918_RS08545 ENOG4105DVT helicase B4918_RS08550 ENOG4105CTD carboxy-peptidase B4918_RS08565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B4918_RS08575 ENOG4105C2W permease B4918_RS08580 ENOG4105DHF Membrane B4918_RS08590 ENOG410890F Dynamin family B4918_RS08600 ENOG4108W0I acetyltransferase B4918_RS08610 ENOG4105KHC sulfurtransferase B4918_RS08635 ENOG4106032 Glutathionylspermidine synthase B4918_RS08695 ENOG4105CPK Glycosyl transferase (Group 1 B4918_RS08710 ENOG4108SZE gCN5-related N-acetyltransferase B4918_RS08730 ENOG41081VK Ribonuclease B4918_RS08795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_RS08805 ENOG4107RWR Sodium hydrogen exchanger B4918_RS08810 ENOG4105CN5 Metallo-Beta-Lactamase B4918_RS08815 ENOG4108Z5V transcriptional regulator, merr family B4918_RS08825 ENOG4105H67 Protein of unknown function (DUF421) B4918_RS08830 ENOG41080C8 DUF218 domain B4918_RS08865 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B4918_RS08875 ENOG4107R0U MotA TolQ exbB proton channel B4918_RS08880 ENOG4105ER2 Ompa motb domain protein B4918_RS08885 ENOG4107YTP response regulator receiver protein B4918_RS08890 ENOG4105CBS Chea signal transduction histidine kinase B4918_RS08895 ENOG4105DD5 Flagellar motor switch protein B4918_RS08910 ENOG4105BZU Histidine kinase B4918_RS08930 ENOG4105E1Q flagellar hook-associated protein B4918_RS08935 ENOG4105DTJ flagellar hook-associated protein B4918_RS08940 ENOG4105DTS flagellar hook-associated B4918_RS08960 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B4918_RS08965 ENOG4108ZC9 flagellar basal-body rod protein flgc B4918_RS08970 ENOG41075Z6 flagellar hook-basal body complex protein fliE B4918_RS08975 ENOG4107U2N Flagellar M-ring protein B4918_RS08980 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B4918_RS09010 ENOG4105BZE flagellar hook protein, FlgE B4918_RS09025 ENOG4107R88 Chemotaxis protein (CheV) B4918_RS09035 ENOG4105I03 Flagellin B4918_RS09040 ENOG4105I03 Flagellin B4918_RS09045 ENOG4105E4C Lytic transglycosylase catalytic B4918_RS09055 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B4918_RS09060 ENOG4105DD5 Flagellar motor switch protein B4918_RS09070 ENOG4105CN7 Flagellar biosynthetic protein FliP B4918_RS09075 ENOG4105VS8 Flagellar biosynthetic protein fliq B4918_RS09085 ENOG4105D00 flagellar biosynthetic protein flhB B4918_RS09090 ENOG4105D7B Flagellar biosynthesis protein flha B4918_RS09095 ENOG4105FZW flagellar biosynthesis regulator FlhF B4918_RS09100 ENOG4105KTQ flagellar basal-body rod protein B4918_RS09105 ENOG4105CPU Monooxygenase B4918_RS09110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_RS09140 ENOG4105KAC Antibiotic biosynthesis monooxygenase B4918_RS09145 ENOG4107QZ7 Cellulose synthase catalytic subunit B4918_RS09170 ENOG4105DUM transcriptional regulator, lysR family B4918_RS09175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS09185 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component B4918_RS09225 ENOG4105CVJ phosphoglycerate mutase B4918_RS09240 ENOG4105K56 Transcriptional regulator B4918_RS09250 ENOG4105CAQ asparagine synthetase B4918_RS09270 ENOG4105PGM cation diffusion facilitator family transporter B4918_RS09285 ENOG4105CKI cobalamin synthesis protein B4918_RS09295 ENOG4108PJD permease B4918_RS09310 ENOG4105DFD Na H antiporter B4918_RS09315 ENOG4105VUF Transcriptional regulator B4918_RS09325 ENOG4105C9Q fumarate hydratase class II B4918_RS09345 ENOG4107QJQ Mate efflux family protein B4918_RS09350 ENOG4105EC3 peptidase S51, dipeptidase E B4918_RS09370 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_RS09540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS09575 ENOG4105K63 Thioredoxin B4918_RS09600 ENOG4105C2M dna polymerase I B4918_RS09660 ENOG4106BRA Membrane B4918_RS09700 ENOG4105CJ1 ABC, transporter B4918_RS09720 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B4918_RS09730 ENOG4108IJ0 Aspartate ammonia-lyase B4918_RS09735 ENOG4105C6K Malic enzyme B4918_RS09800 ENOG4105FVX B4918_RS09805 ENOG4105E09 nadh pyrophosphatase B4918_RS09820 ENOG4105CSR polyphosphate kinase 2 B4918_RS09825 ENOG4105U3E Transcriptional regulator B4918_RS09835 ENOG4105DXI Major Facilitator superfamily B4918_RS09845 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B4918_RS09850 ENOG4105EU0 Major facilitator Superfamily B4918_RS09855 ENOG4105C6T cysteine synthase B4918_RS09875 ENOG4105C8J )-transporter B4918_RS09885 ENOG4105X5K response regulator receiver protein B4918_RS09890 ENOG4105H67 Protein of unknown function (DUF421) B4918_RS09920 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B4918_RS09925 ENOG4105CHR reductase B4918_RS09930 ENOG4105CM2 brancheD-chain amino acid aminotransferase B4918_RS09935 ENOG4105C7K acetolactate synthase B4918_RS09945 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B4918_RS09955 ENOG4105C7B Threonine dehydratase B4918_RS09980 ENOG4105C6X Major Facilitator B4918_RS09985 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b B4918_RS10000 ENOG4105DY9 regulatoR B4918_RS10005 ENOG4105CYC Transferase B4918_RS10030 ENOG41068WN B4918_RS10050 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B4918_RS10065 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) B4918_RS10070 ENOG4105C0X amino acid B4918_RS10110 ENOG410849A acetyltransferase, (GNAT) family B4918_RS10120 ENOG4105K8R UPF0145 protein B4918_RS10135 ENOG4107RHR regulatoR B4918_RS10145 ENOG4105D9N nucleoside B4918_RS10150 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B4918_RS10155 ENOG4105KG3 cytidine deaminase B4918_RS10185 ENOG4108IBT Inherit from COG: transposase B4918_RS10210 ENOG4107RAQ aminopeptidase B4918_RS10255 ENOG4105JVQ RNA Polymerase B4918_RS10260 ENOG4107VMI polysaccharide deacetylase B4918_RS10285 ENOG4105CJW magnesium transporter B4918_RS10290 ENOG4105CNI cell division protein FtsW B4918_RS10335 ENOG4108IMY Transcriptional regulator B4918_RS10360 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS10385 ENOG4105E1K spore germination protein B4918_RS10390 ENOG4107TVC Glycosyl transferase, family 2 B4918_RS10440 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B4918_RS10495 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_RS10500 ENOG410847I Transcriptional regulator, BadM Rrf2 family B4918_RS10510 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B4918_RS10540 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS10620 ENOG4108T5E Copper resistance protein B4918_RS10625 ENOG4105KTB nuclear export factor GLE1 B4918_RS10630 ENOG4107RT3 EamA-like transporter family B4918_RS10635 ENOG4105GZI Transcriptional regulator B4918_RS10640 ENOG4108Z40 Transcriptional regulator B4918_RS10645 ENOG4107ZXU DSBA oxidoreductase B4918_RS10650 ENOG4108TVJ Nitroreductase B4918_RS10660 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B4918_RS10695 ENOG41085W3 Transposase B4918_RS10770 ENOG4105C2M dna polymerase I B4918_RS10860 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS11075 ENOG4106F5Q Membrane B4918_RS11080 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_RS11095 ENOG4105CKI cobalamin synthesis protein B4918_RS11105 ENOG4105C0Z ABC transporter B4918_RS11110 ENOG4108IV0 ABC, transporter B4918_RS11115 ENOG4105C32 Amino acid ABC transporter (Permease) B4918_RS11125 ENOG4105EGI Transcriptional regulator B4918_RS11135 ENOG4105MDS 4-oxalocrotonate tautomerase B4918_RS11155 ENOG4105C4M (Ubiquinol oxidase) subunit I B4918_RS11160 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B4918_RS11165 ENOG4108JJ9 ABC, transporter B4918_RS11170 ENOG4108JJ8 (ABC) transporter B4918_RS11180 ENOG4105K64 Glycosyl transferase, family 2 B4918_RS11190 ENOG4108UT6 Transferase hexapeptide repeat containing protein B4918_RS11245 ENOG4105BZ1 (ABC) transporter B4918_RS11250 ENOG4105EFI regulatoR B4918_RS11255 ENOG4105BZU Histidine kinase B4918_RS11265 ENOG4108VQJ O-methyltransferase B4918_RS11275 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B4918_RS11280 ENOG4108ZJ4 polysaccharide deacetylase B4918_RS11300 ENOG4105D6E homoserine dehydrogenase B4918_RS11325 ENOG4108KGH TRANSCRIPTIONal B4918_RS11345 ENOG4105KT7 mgtC SapB transporter B4918_RS11350 ENOG4105VRR gCN5-related N-acetyltransferase B4918_RS11360 ENOG4105DUU IucA IucC family protein B4918_RS11365 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS11380 ENOG4108WBH protein TIM barrel B4918_RS11385 ENOG4105YWU small acid-soluble spore protein B4918_RS11395 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B4918_RS11400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_RS11415 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS11465 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS11475 ENOG4105YVS arsR family transcriptional regulator B4918_RS11480 ENOG4105CPC Aldo Keto reductase B4918_RS11485 ENOG4107XZQ multidrug resistance protein B4918_RS11515 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS11535 ENOG4108K88 Membrane B4918_RS11540 ENOG4108WPJ Ferritin-like domain B4918_RS11555 ENOG4105DEN Luciferase family B4918_RS11570 ENOG4105VMI -acetyltransferase B4918_RS11575 ENOG4107QM2 Aldo Keto reductase B4918_RS11580 ENOG4105CKI cobalamin synthesis protein B4918_RS11590 ENOG4105DSE periplasmic solute binding protein B4918_RS11600 ENOG4105K4T epimerase B4918_RS11610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B4918_RS11635 ENOG4105CVJ phosphoglycerate mutase B4918_RS11655 ENOG4107T5V SNARE associated Golgi B4918_RS11670 ENOG4108PJD permease B4918_RS11680 ENOG4108S4H thioesterase Superfamily protein B4918_RS11690 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_RS11710 ENOG4105SXS Protein of unknown function (DUF456) B4918_RS11715 ENOG4105C37 (CBS) domain B4918_RS11745 ENOG4108Z7R Chaperone CsaA B4918_RS11765 ENOG4108ZRV stage ii sporulation protein p B4918_RS11775 ENOG4108VXD carboxy-peptidase B4918_RS11785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B4918_RS11805 ENOG4108ZRV stage ii sporulation protein p B4918_RS11815 ENOG4108X4Q Hydrolase B4918_RS11820 ENOG41082F9 transcriptional regulator B4918_RS11825 ENOG4105D94 Major Facilitator Superfamily B4918_RS11835 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B4918_RS11840 ENOG4107RBS Methyltransferase B4918_RS11855 ENOG41087PP glycosyltransferase MGT family B4918_RS11860 ENOG4108JYZ YitT family B4918_RS11865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_RS11895 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B4918_RS11915 ENOG4106PAW secretion accessory protein EsaA YueB B4918_RS11925 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) B4918_RS12000 ENOG4105KBJ sporulation protein ytfj B4918_RS12025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B4918_RS12045 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B4918_RS12050 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily B4918_RS12060 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein B4918_RS12085 ENOG4105CNW domain protein B4918_RS12095 ENOG4108V06 Glutathione peroxidase B4918_RS12110 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B4918_RS12120 ENOG4108IUE nitrate reductase beta subunit B4918_RS12125 ENOG4105R3A Nitrate reductase B4918_RS12135 ENOG4107V6Q Cyclic nucleotide-binding domain B4918_RS12140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B4918_RS12145 ENOG4105D06 uba thif-type nad fad binding protein B4918_RS12150 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_RS12155 ENOG4108ZAF Molybdopterin B4918_RS12185 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B4918_RS12190 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B4918_RS12195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B4918_RS12200 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B4918_RS12205 ENOG4108IFG nitrite reductase, (NAD(P)H) B4918_RS12210 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B4918_RS12245 ENOG4105MCT stage V sporulation protein S B4918_RS12295 ENOG4105C5H ABC transporter B4918_RS12310 ENOG4108UUM single-stranded DNA-binding protein B4918_RS12335 ENOG4107YX5 Pfam:DUF548 B4918_RS12340 ENOG4105C75 arginyL-tRNA synthetase B4918_RS12385 ENOG4105C5S asparaginyl-tRNA synthetase B4918_RS12390 ENOG4105C8J )-transporter B4918_RS12395 ENOG4108EF6 Proline imino-peptidase B4918_RS12410 ENOG4107XGZ Hydrolase B4918_RS12415 ENOG4105CY2 Citrate transporter B4918_RS12435 ENOG4105KD7 acetyltransferase B4918_RS12450 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase B4918_RS12475 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 B4918_RS12505 ENOG4107RVG penicillin-binding protein B4918_RS12515 ENOG4105E9Q Acyl-transferase B4918_RS12520 ENOG4108UT2 hemolysin iii B4918_RS12530 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B4918_RS12540 ENOG4108RCR degv family B4918_RS12550 ENOG4108KF3 Electron transport protein SCO1 SenC B4918_RS12555 ENOG4107Y70 Heat shock protein B4918_RS12560 ENOG4105CAQ asparagine synthetase B4918_RS12575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B4918_RS12580 ENOG4108MES Periplasmic binding protein B4918_RS12585 ENOG4105F0I Aminotransferase B4918_RS12615 ENOG4105D8X mechanosensitive ion channel B4918_RS12620 ENOG4105BZU Histidine kinase B4918_RS12625 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_RS12630 ENOG4106KNT transcriptional regulator B4918_RS12635 ENOG4107ZY0 Phenazine biosynthesis-like protein B4918_RS12665 ENOG4105C6Z Gluconate B4918_RS12675 ENOG4108YV3 Protein of unknown function (DUF2711) B4918_RS12710 ENOG4105E90 ABC transporter B4918_RS12745 ENOG4105C37 (CBS) domain B4918_RS12775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_RS12790 ENOG4107S4Y M20 DapE family protein YgeY B4918_RS12795 ENOG4108TSC N-acetyltransferase B4918_RS12800 ENOG4108JUB Transcriptional regulator B4918_RS12805 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B4918_RS12850 ENOG410841Q phosphoesterase PA-phosphatase related protein B4918_RS12860 ENOG4105SZ6 Thioredoxin B4918_RS12905 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_RS12960 ENOG4105BZ4 penicillin-binding protein B4918_RS12970 ENOG4105CZM Major Facilitator B4918_RS12975 ENOG4105W8X HesB YadR YfhF-family protein B4918_RS12985 ENOG4105DXD 2-methylcitrate dehydratase B4918_RS12990 ENOG4105CR4 methylisocitrate lyase B4918_RS12995 ENOG4105C1G acyl-Coa dehydrogenase B4918_RS13000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B4918_RS13010 ENOG4105N14 lysine exporter protein LysE YggA B4918_RS13015 ENOG4105E39 Enoyl-CoA hydratase B4918_RS13030 ENOG4107RFY SbcCD D subunit B4918_RS13035 ENOG4105EYH Exonuclease B4918_RS13060 ENOG4105FCD Major Facilitator B4918_RS13070 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B4918_RS13075 ENOG4105E4F Isochorismate synthase B4918_RS13080 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B4918_RS13085 ENOG4105WQI isochorismatase B4918_RS13090 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS13095 ENOG4105WQT MbtH domain protein B4918_RS13100 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_RS13115 ENOG4105K70 DNA-binding protein B4918_RS13135 ENOG4105BZG amino acid carrier protein B4918_RS13155 ENOG4105FE9 pseudouridine synthase B4918_RS13160 ENOG4105C22 threonyL-tRNA synthetase B4918_RS13165 ENOG4105C19 ABC transporter B4918_RS13200 ENOG41081I9 integral membrane protein B4918_RS13210 ENOG4108Y4K DNA-binding transcriptional activator B4918_RS13225 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B4918_RS13235 ENOG4105EYF MMPL domain protein B4918_RS13260 ENOG4105WCN acetyltransferase B4918_RS13285 ENOG4105C1Q protoporphyrinogen oxidase B4918_RS13295 ENOG41068WN B4918_RS13325 ENOG4107V2S Transcriptional regulator B4918_RS13330 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B4918_RS13340 ENOG4105DND Transcriptional regulator B4918_RS13345 ENOG4108RPX mosc domain containing protein B4918_RS13360 ENOG4105BZ1 (ABC) transporter B4918_RS13365 ENOG4105BZ1 (ABC) transporter B4918_RS13395 ENOG4108JCI Transcriptional regulator B4918_RS13425 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) B4918_RS13430 ENOG4108KPJ rna polymerase sigma factor B4918_RS13455 ENOG4105F32 YngK protein B4918_RS13480 ENOG4105RD7 BadF BadG BcrA BcrD B4918_RS13485 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B4918_RS13490 ENOG4107STF Involved in phosphonate degradation (By similarity) B4918_RS13495 ENOG4105C7B Threonine dehydratase B4918_RS13500 ENOG4108INS Transcriptional regulator B4918_RS13515 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B4918_RS13525 ENOG4105C1J atp-dependent rna helicase B4918_RS13530 ENOG41088CC tellurite resistance protein tehB B4918_RS13545 ENOG4107RA9 decarboxylase B4918_RS13590 ENOG4105CIN aminoacyl-histidine dipeptidase B4918_RS13615 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS13625 ENOG4105EJ9 Membrane B4918_RS13670 ENOG4105W8Z 4'-phosphopantetheinyl transferase B4918_RS13680 ENOG4105CHR reductase B4918_RS13740 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS13755 ENOG4108W0I acetyltransferase B4918_RS13760 ENOG4107QQG Dehydrogenase B4918_RS13765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_RS13770 ENOG4108IAJ Nad-dependent epimerase dehydratase B4918_RS13775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_RS13790 ENOG4105FJR Lmbe family B4918_RS13800 ENOG4105IIU Aminopeptidase B4918_RS13805 ENOG4108SC4 )-transporter B4918_RS13855 ENOG4108IMY Transcriptional regulator B4918_RS13870 ENOG4107VMI polysaccharide deacetylase B4918_RS13915 ENOG41085W3 Transposase B4918_RS13930 ENOG4107RVG penicillin-binding protein B4918_RS13945 ENOG4107RF6 penicillin-binding protein B4918_RS13950 ENOG4107RF6 penicillin-binding protein B4918_RS13960 ENOG4105DIN metallophosphoesterase B4918_RS13970 ENOG4105CJ1 ABC, transporter B4918_RS13980 ENOG4107Z3H Transcriptional regulator, TetR family B4918_RS13995 ENOG4105C1G acyl-Coa dehydrogenase B4918_RS14000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B4918_RS14005 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B4918_RS14010 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B4918_RS14015 ENOG4105E39 Enoyl-CoA hydratase B4918_RS14020 ENOG4107QX3 carboxylase B4918_RS14025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B4918_RS14035 ENOG41085W3 Transposase B4918_RS14060 ENOG4105DZ1 carboxypeptidase B4918_RS14075 ENOG4105T9C HD domain B4918_RS14090 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B4918_RS14110 ENOG41075H3 AraC family transcriptional regulator B4918_RS14140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B4918_RS14150 ENOG4105CHR reductase B4918_RS14155 ENOG4105KVH Transcriptional regulator B4918_RS14225 ENOG410900G Protein of unknown function (DUF421) B4918_RS14235 ENOG4108V4B ThiJ pfpI B4918_RS14245 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein B4918_RS14255 ENOG4105DK7 lysyl-tRNA synthetase B4918_RS14280 ENOG4106NZI LysR family Transcriptional regulator B4918_RS14285 ENOG4105CPC Aldo Keto reductase B4918_RS14330 ENOG4105D6E homoserine dehydrogenase B4918_RS14340 ENOG4105CPF Cell wall formation (By similarity) B4918_RS14345 ENOG4105ETU transcriptional activator (TenA B4918_RS14440 ENOG410667J hydrolase B4918_RS14445 ENOG4105BZU Histidine kinase B4918_RS14450 ENOG4107RF6 penicillin-binding protein B4918_RS14475 ENOG4108FPN Integrase B4918_RS14505 ENOG41080TC multidrug resistance protein B4918_RS14540 ENOG4105BZU Histidine kinase B4918_RS14560 ENOG4105CVP deoxyribo-dipyrimidine photolyase B4918_RS14590 ENOG4108B31 Spore germination protein B4918_RS14610 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B4918_RS14630 ENOG4105WG9 Conserved Protein B4918_RS14635 ENOG4105E1K spore germination protein B4918_RS14690 ENOG4105DU0 nucleoside hydrolase B4918_RS14750 ENOG4105XZV Protein of unknown function (DUF3243) B4918_RS14760 ENOG4105F6S Spore photoproduct lyase B4918_RS14785 ENOG4108JJB ABC transporter B4918_RS14800 ENOG4108HGU Histidine kinase B4918_RS14895 ENOG4105CB2 alcohol dehydrogenase B4918_RS14900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B4918_RS14905 ENOG4105CJN penicillin-binding protein B4918_RS14955 ENOG4105D13 transposase B4918_RS14995 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B4918_RS15020 ENOG4107Y9U Membrane B4918_RS15040 ENOG4105EGD dinuclear metal center protein, YbgI family B4918_RS15045 ENOG4105M6F mutator MutT protein B4918_RS15080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_RS15085 ENOG4108Z4K mutator MutT protein B4918_RS15110 ENOG4108XI2 Domain of unknown function (DUF1963) B4918_RS15140 ENOG4108NRW Phospholipase, patatin family B4918_RS15145 ENOG4105KWG Pfam:DUF1696 B4918_RS15170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_RS15180 ENOG4105PKS Excinuclease abc c subunit domain protein B4918_RS15215 ENOG41087PP glycosyltransferase MGT family B4918_RS15235 ENOG4107VFR oxidoreductase B4918_RS15260 ENOG4105U0R haloacid dehalogenase-like hydrolase B4918_RS15265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS15270 ENOG4105BZU Histidine kinase B4918_RS15290 ENOG4107WD8 ABC transporter, permease B4918_RS15305 ENOG4105DY8 decarboxylase B4918_RS15320 ENOG4108IUM Glycogen debranching enzyme B4918_RS15330 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic B4918_RS15350 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B4918_RS15355 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B4918_RS15360 ENOG4105FDR Membrane B4918_RS15365 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_RS15415 ENOG4105MSI germination protein ypeb B4918_RS15445 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) B4918_RS15450 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) B4918_RS15455 ENOG4107Z3H Transcriptional regulator, TetR family B4918_RS15475 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B4918_RS15495 ENOG4105E98 transcriptional regulator DeoR family B4918_RS15510 ENOG41062ES Transcriptional regulator B4918_RS15530 ENOG4107QKR Dehydrogenase B4918_RS15540 ENOG4107RUY (E1 component), alpha subunit B4918_RS15550 ENOG4105E1F short-chain dehydrogenase reductase B4918_RS15580 ENOG4107SQ8 Glycine betaine B4918_RS15585 ENOG4108IJ7 Glycine betaine B4918_RS15595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_RS15610 ENOG4105E66 phosphoriboisomerase A B4918_RS15615 ENOG41082BV acetyltransferase B4918_RS15635 ENOG4108M1A Chitin-binding protein B4918_RS15640 ENOG41087PP glycosyltransferase MGT family B4918_RS15650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B4918_RS15665 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_RS15670 ENOG4105MSB protein, conserved in bacteria B4918_RS15695 ENOG4108Z7F N-acetyltransferase B4918_RS15720 ENOG4105KEG ribosomal-protein-alanine acetyltransferase B4918_RS15725 ENOG4105EEM helicase B4918_RS15740 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_RS15795 ENOG4108M1A Chitin-binding protein B4918_RS15815 ENOG4105BZG amino acid carrier protein B4918_RS15820 ENOG4105C26 Dehydrogenase B4918_RS15825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B4918_RS15835 ENOG4105CTU Proline racemase B4918_RS15840 ENOG41080HI glycine oxidase B4918_RS15850 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein B4918_RS15880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B4918_RS15885 ENOG4105DCI Phosphohydrolase B4918_RS15890 ENOG4107T5V SNARE associated Golgi B4918_RS15900 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B4918_RS15915 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_RS15930 ENOG4107SET aldo keto reductase B4918_RS15970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_RS15975 ENOG4105BZU Histidine kinase B4918_RS15980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS16005 ENOG4105DPN Oligoendopeptidase f B4918_RS16010 ENOG4105EPR degv family B4918_RS16070 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B4918_RS16125 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS16140 ENOG41085W3 Transposase B4918_RS16215 ENOG4105CAR Terminase, large subunit B4918_RS16300 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS16325 ENOG4108ZUE Phage regulatory protein rha B4918_RS16375 ENOG4107BMA Transglycosylase associated protein B4918_RS16390 ENOG41089UC methyltransferase, type 11 B4918_RS16430 ENOG4105CHM Aminotransferase B4918_RS16445 ENOG4108ZMI UPF0477 protein B4918_RS16460 ENOG4105DVE abc transporter atp-binding protein B4918_RS16510 ENOG4105C02 permease B4918_RS16530 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B4918_RS16535 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B4918_RS16540 ENOG4105D7T ABC transporter B4918_RS16565 ENOG4108AQF aminoglycoside N(3)-acetyltransferase B4918_RS16600 ENOG4107VC0 DNA alkylation repair enzyme B4918_RS16605 ENOG4105C6T cysteine synthase B4918_RS16610 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_RS16630 ENOG4107VMI polysaccharide deacetylase B4918_RS16650 ENOG4108ZCF integral membrane protein B4918_RS16655 ENOG4105E0M Sulfatase B4918_RS16660 ENOG4105C5H ABC transporter B4918_RS16665 ENOG4105EYF MMPL domain protein B4918_RS16670 ENOG41082JN Transcriptional regulator B4918_RS16695 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B4918_RS16705 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B4918_RS16740 ENOG41069ER domain protein B4918_RS16770 ENOG4105D4B ABC, transporter B4918_RS16780 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane B4918_RS16785 ENOG4105C2J ABC transporter B4918_RS16790 ENOG4105DKT Transcriptional regulator B4918_RS16795 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) B4918_RS16805 ENOG41061GT Aldolase B4918_RS16825 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) B4918_RS16860 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_RS16890 ENOG4105E0Y RtcB Protein B4918_RS16895 ENOG4105ECK Fatty Acid Desaturase B4918_RS16905 ENOG4107RBI VanW family B4918_RS16910 ENOG4105G6Z alkaline phosphatase B4918_RS16920 ENOG4105VMP Transcriptional regulator B4918_RS16940 ENOG41068WN B4918_RS16970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B4918_RS16995 ENOG4105C8Y Acetylornithine aminotransferase B4918_RS17000 ENOG4105CH6 catalase B4918_RS17030 ENOG41090AA B4918_RS17035 ENOG4106BHF B4918_RS17045 ENOG4108IBT Inherit from COG: transposase B4918_RS17065 ENOG4108TVJ Nitroreductase B4918_RS17070 ENOG4105FS7 Transcriptional regulator B4918_RS17090 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B4918_RS17095 ENOG4105WEC Molybdate metabolism regulator B4918_RS17100 ENOG4105CMR udp-glucose 4-epimerase B4918_RS17105 ENOG4105C19 ABC transporter B4918_RS17130 ENOG4108XET gCN5-related N-acetyltransferase B4918_RS17140 ENOG4105E09 nadh pyrophosphatase B4918_RS17145 ENOG4108PCN EamA-like transporter family B4918_RS17190 ENOG410635A Membrane B4918_RS17200 ENOG4108IQI permease B4918_RS17265 ENOG4105BZU Histidine kinase B4918_RS17295 ENOG4107RF6 penicillin-binding protein B4918_RS17300 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B4918_RS17330 ENOG4105P4J Allophanate hydrolase, subunit 1 B4918_RS17335 ENOG4107258 Transcriptional regulator B4918_RS17345 ENOG4106N3A copper homeostasis protein cutc B4918_RS17350 ENOG4108ZHR arsR family transcriptional regulator B4918_RS17360 ENOG4105FDT acyl-CoA dehydrogenase B4918_RS17375 ENOG4105DWD nucleoside recognition domain protein B4918_RS17415 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B4918_RS17445 ENOG4105E2A Dehydrogenase B4918_RS17455 ENOG4108IJ0 Aspartate ammonia-lyase B4918_RS17460 ENOG4105HDK L-asparaginase B4918_RS17465 ENOG4108IMY Transcriptional regulator B4918_RS17485 ENOG4108B31 Spore germination protein B4918_RS17495 ENOG4105BZU Histidine kinase B4918_RS17520 ENOG41075H3 AraC family transcriptional regulator B4918_RS17535 ENOG4105YWU small acid-soluble spore protein B4918_RS17540 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B4918_RS17545 ENOG4105CUB amino acid B4918_RS17550 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_RS17555 ENOG4108NHD germination protein B4918_RS17560 ENOG4108Q8B Spore germination protein B4918_RS17600 ENOG4106A3M Cytochrome p-450 B4918_RS17615 ENOG4105CGH 5'-nucleotidase B4918_RS17625 ENOG4105CHJ isochorismatase hydrolase B4918_RS17680 ENOG4105F6J Alpha beta hydrolase fold B4918_RS17695 ENOG4108606 TspO/MBR family B4918_RS17700 ENOG4105CVP deoxyribo-dipyrimidine photolyase B4918_RS17715 ENOG4108TWJ NADH dehydrogenase subunit 5 B4918_RS17720 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B4918_RS17735 ENOG4105E1K spore germination protein B4918_RS17740 ENOG4107VMI polysaccharide deacetylase B4918_RS17750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B4918_RS17755 ENOG4105DSE periplasmic solute binding protein B4918_RS17760 ENOG4105CC5 ABC transporter B4918_RS17765 ENOG4105DIK (ABC) transporter B4918_RS17785 ENOG4105D6J arsenicaL-resistance protein B4918_RS17790 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_RS17795 ENOG41085FC arsR family transcriptional regulator B4918_RS17810 ENOG4105EGI Transcriptional regulator B4918_RS17840 ENOG41085W3 Transposase B4918_RS17860 ENOG4105VZ8 Transcriptional regulator B4918_RS17870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) B4918_RS17885 ENOG4107P5I polyketide synthase B4918_RS17890 ENOG4108IG5 Transcriptional regulator B4918_RS17895 ENOG4105CHR reductase B4918_RS17900 ENOG4108YXU transcriptional regulator AsnC family B4918_RS17950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS17955 ENOG41062D9 Histidine kinase B4918_RS17995 ENOG4105DNP FAD linked oxidase domain protein B4918_RS18010 ENOG4105C19 ABC transporter B4918_RS18045 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B4918_RS18050 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_RS18070 ENOG4105K6H D-cysteine desulfhydrase B4918_RS18090 ENOG4105JQZ Methyltransferase B4918_RS18110 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) B4918_RS18120 ENOG4105BZU Histidine kinase B4918_RS18135 ENOG4108U05 Transcriptional regulator B4918_RS18140 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 B4918_RS18150 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B4918_RS18165 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B4918_RS18185 ENOG4108JQ1 Dehydrogenase B4918_RS18190 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B4918_RS18205 ENOG41082W1 Cupin 2, conserved barrel domain protein B4918_RS18215 ENOG410874W AraC family transcriptional regulator B4918_RS18240 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS18250 ENOG4108IG5 Transcriptional regulator B4918_RS18450 ENOG4108VXD carboxy-peptidase B4918_RS18455 ENOG4105PNM synthesis protein B4918_RS18465 ENOG4108ISG Major Facilitator B4918_RS18480 ENOG4107MII Sugar-specific transcriptional regulator TrmB B4918_RS18485 ENOG4105CZM Major Facilitator B4918_RS18500 ENOG4105CRW Short chain fatty acid transporter B4918_RS18510 ENOG4105DYS nad(p)h dehydrogenase (quinone) B4918_RS18570 ENOG4108K8S endonuclease I B4918_RS18580 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B4918_RS18585 ENOG4108Z66 YbaK ebsC protein B4918_RS18605 ENOG4105KVH Transcriptional regulator B4918_RS18610 ENOG4108RCM Nitroreductase B4918_RS18645 ENOG4108PSK reductase B4918_RS18725 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_RS18730 ENOG4105DKQ ROK family B4918_RS18735 ENOG4106UW1 Major Facilitator superfamily B4918_RS18740 ENOG4108UW5 maltose o-acetyltransferase B4918_RS18745 ENOG4105C31 Tryptophanyl-tRNA synthetase B4918_RS18750 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B4918_RS18800 ENOG4105EV4 Multidrug resistance protein mdtH B4918_RS18830 ENOG4105C37 (CBS) domain B4918_RS18855 ENOG4105DDN Pentapeptide repeat-containing protein B4918_RS18860 ENOG4105XDF Protein of unknown function (DUF1272) B4918_RS18865 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B4918_RS18870 ENOG4105CMG Carbohydrate kinase B4918_RS18875 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B4918_RS18885 ENOG4105CV1 Transketolase (EC 2.2.1.1) B4918_RS18890 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B4918_RS18915 ENOG4105C44 Serine transporter B4918_RS18945 ENOG4105KVH Transcriptional regulator B4918_RS18950 ENOG4108TZY GntR Family Transcriptional Regulator B4918_RS18955 ENOG4105D9R oxidoreductase B4918_RS19010 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B4918_RS19015 ENOG4105KVH Transcriptional regulator B4918_RS19020 ENOG4107SCK Monooxygenase B4918_RS19035 ENOG4108ZJ4 polysaccharide deacetylase B4918_RS19090 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) B4918_RS19160 ENOG4105CIS alcohol dehydrogenase B4918_RS19200 ENOG4108TN2 lmbE family B4918_RS19210 ENOG4107R3E Citrate transporter B4918_RS19225 ENOG4108MES Periplasmic binding protein B4918_RS19230 ENOG4105EHG Permease protein B4918_RS19235 ENOG4105DQ5 transport system permease protein B4918_RS19240 ENOG4105NX3 Membrane B4918_RS19260 ENOG4107CUJ Protein of unknown function (DUF2690) B4918_RS19270 ENOG4107V2S Transcriptional regulator B4918_RS19290 ENOG4105C98 muts2 protein B4918_RS19300 ENOG4105E5K Alpha-amylase B4918_RS19305 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_RS19310 ENOG4105DPN Oligoendopeptidase f B4918_RS19315 ENOG4105DWY Agmatine deiminase B4918_RS19345 ENOG4108A04 Beta-lactamase B4918_RS19355 ENOG4105E5T Major Facilitator Superfamily B4918_RS19370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B4918_RS19380 ENOG41082BM Transcriptional regulator, arsr family B4918_RS19385 ENOG4105CIS alcohol dehydrogenase B4918_RS19410 ENOG4105C09 Bile acid B4918_RS19415 ENOG4105CQB FAD linked oxidase domain protein B4918_RS19435 ENOG4105CEP NADH dehydrogenase B4918_RS19460 ENOG4105D2T synthase B4918_RS19475 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) B4918_RS19480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_RS19485 ENOG4105C1B dTDP-glucose 4-6-dehydratase B4918_RS19490 ENOG4105C5E polysaccharide biosynthesis protein B4918_RS19515 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B4918_RS19520 ENOG4108M1A Chitin-binding protein B4918_RS19530 ENOG4105E1K spore germination protein B4918_RS19550 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B4918_RS19565 ENOG4105FAW cDP-glucose 4,6-dehydratase B4918_RS19620 ENOG4105BZU Histidine kinase B4918_RS19625 ENOG4105C5H ABC transporter B4918_RS19630 ENOG41067SE Tetr family transcriptional regulator B4918_RS19635 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity B4918_RS19645 ENOG4108VXD carboxy-peptidase B4918_RS19650 ENOG4107DUR UPF0457 protein B4918_RS19670 ENOG4105BZU Histidine kinase B4918_RS19680 ENOG4105KT7 mgtC SapB transporter B4918_RS19690 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_RS19695 ENOG41073R8 VanW family B4918_RS19705 ENOG4108R1P B4918_RS19725 ENOG4105VEQ Cold shock protein B4918_RS19745 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B4918_RS19765 ENOG410904N short-chain dehydrogenase reductase B4918_RS19775 ENOG4106IQC argininosuccinate lyase B4918_RS19790 ENOG4108IA2 Sodium pantothenate symporter B4918_RS19800 ENOG4105C26 Dehydrogenase B4918_RS19805 ENOG4105CHR reductase B4918_RS19815 ENOG4105EWU Squalene--hopene cyclase B4918_RS19825 ENOG4105FR1 rard protein B4918_RS19830 ENOG410696E Membrane B4918_RS19845 ENOG4105D1F ATP-binding protein B4918_RS19855 ENOG4108ZAF Molybdopterin B4918_RS19860 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_RS19865 ENOG4105D06 uba thif-type nad fad binding protein B4918_RS19870 ENOG4105TMB Formate nitrite transporter B4918_RS19885 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B4918_RS19890 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B4918_RS19900 ENOG4108JB9 formate dehydrogenase B4918_RS19910 ENOG4105E1K spore germination protein B4918_RS19980 ENOG4107QJT sodium dicarboxylate symporter B4918_RS19985 ENOG4108KGH TRANSCRIPTIONal B4918_RS19995 ENOG4105EMN RNA polymerase sigma factor B4918_RS20005 ENOG4105CIG ABC transporter B4918_RS20025 ENOG4105D9R oxidoreductase B4918_RS20035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B4918_RS20045 ENOG4105K4P CoA-binding domain protein B4918_RS20050 ENOG4105C0H protease B4918_RS20055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS20065 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B4918_RS20070 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B4918_RS20075 ENOG4105W8X HesB YadR YfhF-family protein B4918_RS20100 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B4918_RS20105 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_RS20120 ENOG4108I0Z Aconitate hydratase B4918_RS20150 ENOG4105E5W Transporter B4918_RS20160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_RS20180 ENOG4107F3J Amp-dependent synthetase and ligase B4918_RS20185 ENOG4107ZYJ bioY protein B4918_RS20190 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS20195 ENOG4108IMY Transcriptional regulator B4918_RS20235 ENOG4107AYK membrAne B4918_RS20250 ENOG4105BZU Histidine kinase B4918_RS20255 ENOG4105FBA Phospholipase Carboxylesterase B4918_RS20260 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B4918_RS20265 ENOG4105CK7 Sodium proline symporter B4918_RS20275 ENOG4105CBC glutamate synthase B4918_RS20280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B4918_RS20285 ENOG4108VJ1 Transcriptional regulator (CarD family B4918_RS20290 ENOG4108903 Formimidoylglutamase B4918_RS20350 ENOG4107QIV Cytochrome c biogenesis protein B4918_RS20365 ENOG4105CH2 amidohydrolase B4918_RS20375 ENOG4105CJ1 ABC, transporter B4918_RS20395 ENOG4107RSM transcriptional regulator B4918_RS20400 ENOG4105VAW lrga family B4918_RS20450 ENOG4105BZ1 (ABC) transporter B4918_RS20455 ENOG4105BZ1 (ABC) transporter B4918_RS20490 ENOG4108HW3 (ABC) transporter B4918_RS20495 ENOG4105CGH 5'-nucleotidase B4918_RS20505 ENOG4108SVB resolvase B4918_RS20525 ENOG4105K7K Transcriptional regulator B4918_RS20530 ENOG4105C5F glutamine synthetase B4918_RS20535 ENOG4105KV4 Transcriptional regulator B4918_RS20540 ENOG4105CXI aluminum resistance protein B4918_RS20545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B4918_RS20550 ENOG4105EN6 Membrane B4918_RS20555 ENOG4106F1P AAA ATPase, central domain protein B4918_RS20585 ENOG41069ER domain protein B4918_RS20595 ENOG4105DM4 PTS System B4918_RS20600 ENOG4105DE4 1-phosphofructokinase B4918_RS20605 ENOG4105E98 transcriptional regulator DeoR family B4918_RS20610 ENOG4107QW4 alcohol dehydrogenase B4918_RS20615 ENOG4108SJC Membrane B4918_RS20630 ENOG4105C85 amino acid B4918_RS20660 ENOG4105TMB Formate nitrite transporter B4918_RS20665 ENOG4105K70 DNA-binding protein B4918_RS20675 ENOG4105C59 p-type ATPase B4918_RS20680 ENOG410681U heavy metal transport detoxification protein B4918_RS20685 ENOG4105VPX protein, conserved in bacteria B4918_RS20705 ENOG4105NIV Esterase B4918_RS20710 ENOG4105E0A ABC, transporter B4918_RS20735 ENOG4105CGK Exodeoxyribonuclease III B4918_RS20745 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B4918_RS20750 ENOG4105D03 DNA-3-methyladenine glycosylase II B4918_RS20780 ENOG4105BZU Histidine kinase B4918_RS20820 ENOG41067MG lrgb family B4918_RS20845 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS20850 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B4918_RS20860 ENOG4105F0V Cell wall hydrolase B4918_RS20875 ENOG4105E0M Sulfatase B4918_RS20880 ENOG410890F Dynamin family B4918_RS20915 ENOG4105DQU oxidoreductase, subunit beta B4918_RS20920 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein B4918_RS20925 ENOG4108IGT Dipeptidase B4918_RS20930 ENOG4105MCT stage V sporulation protein S B4918_RS20935 ENOG4105D48 metallophosphoesterase B4918_RS20960 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B4918_RS20975 ENOG4105XZV Protein of unknown function (DUF3243) B4918_RS20980 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B4918_RS21000 ENOG4105UIB (ABC) transporter B4918_RS21005 ENOG4108JQ9 ABC transporter B4918_RS21010 ENOG4105DIH basic membrane B4918_RS21015 ENOG4105FDP GntR family transcriptional regulator B4918_RS21025 ENOG4105CNU cell division protein FtsK B4918_RS21035 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B4918_RS21045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B4918_RS21055 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B4918_RS21060 ENOG4108S0H Dipicolinic acid synthetase, b subunit B4918_RS21065 ENOG4105E35 Dipicolinate synthase subunit A B4918_RS21075 ENOG4105C1V Peptidase, M16 B4918_RS21095 ENOG4105DTN riboflavin biosynthesis protein ribF B4918_RS21110 ENOG4105W7A Protein of unknown function (DUF503) B4918_RS21120 ENOG4105VHM ribosomal protein B4918_RS21125 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B4918_RS21130 ENOG4105CHV Transcription elongation factor NusA B4918_RS21140 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B4918_RS21150 ENOG4105DZP Membrane-associated zinc metalloprotease B4918_RS21155 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B4918_RS21160 ENOG4105KNE Phosphatidate cytidylyltransferase B4918_RS21165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B4918_RS21175 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B4918_RS21205 ENOG4108HE4 integrase family B4918_RS21215 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B4918_RS21220 ENOG4105C79 DNA protecting protein DprA B4918_RS21225 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B4918_RS21240 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B4918_RS21265 ENOG4105VB6 UPF0109 protein B4918_RS21285 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B4918_RS21290 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B4918_RS21305 ENOG4105CHR reductase B4918_RS21310 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B4918_RS21325 ENOG4105CB5 ATP-dependent DNA helicase recG B4918_RS21330 ENOG4105DP4 dak2 domain fusion protein ylov B4918_RS21335 ENOG4108ZAA Alkaline-shock protein B4918_RS21350 ENOG4105FJ0 thiamine B4918_RS21355 ENOG4105DJV ribulose-phosphate 3-epimerase B4918_RS21360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B4918_RS21365 ENOG4105D9P serine threonine protein kinase B4918_RS21370 ENOG4108ZF3 Phosphatase B4918_RS21380 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B4918_RS21395 ENOG4105C25 Primosomal protein n' B4918_RS21400 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B4918_RS21420 ENOG4105DSJ YicC domain protein B4918_RS21430 ENOG4105F23 Fibronectin-binding protein B4918_RS21520 ENOG4105C34 Pseudouridine synthase B4918_RS21535 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) B4918_RS21545 ENOG4105DBK s4 domain protein B4918_RS21550 ENOG41067XK integral membrane protein B4918_RS21560 ENOG4105DFA alanine racemase domain protein B4918_RS21565 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B4918_RS21570 ENOG4105WR5 sporulation protein, YlmC YmxH family B4918_RS21580 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS21590 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B4918_RS21595 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B4918_RS21605 ENOG4105D4A Cell wall formation (By similarity) B4918_RS21610 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B4918_RS21615 ENOG4105CNI cell division protein FtsW B4918_RS21630 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B4918_RS21635 ENOG4105CJN penicillin-binding protein B4918_RS21640 ENOG4105CJN penicillin-binding protein B4918_RS21680 ENOG4105KNH Nucleic acid-binding protein B4918_RS21690 ENOG41063PX domain protein B4918_RS21695 ENOG4105D78 K07001 NTE family protein B4918_RS21700 ENOG4105H20 Sporulation integral membrane protein YlbJ B4918_RS21710 ENOG4106H78 methyltransferase B4918_RS21730 ENOG4107TB6 phosphoglycerate mutase B4918_RS21745 ENOG4106UY4 Inherit from COG: Scp-like extracellular B4918_RS21795 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B4918_RS21805 ENOG4105CNI cell division protein FtsW B4918_RS21820 ENOG4108IAB Phoh family B4918_RS21840 ENOG4105QA2 B4918_RS21845 ENOG4105CI3 gtp-binding protein typa B4918_RS21855 ENOG4105ECY inositol monophosphatase B4918_RS21875 ENOG4105CXN decarboxylase B4918_RS21925 ENOG4105CPP Dehydrogenase, E1 component B4918_RS21940 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B4918_RS21945 ENOG4108X4Q Hydrolase B4918_RS21960 ENOG4105CN5 Metallo-Beta-Lactamase B4918_RS21965 ENOG4107ZYR domain protein B4918_RS22000 ENOG4108XRC Protein of unknown function (DUF458) B4918_RS22010 ENOG4107IN1 Protein of unknown function (DUF1797) B4918_RS22025 ENOG4105EPM Diguanylate phosphodiesterase B4918_RS22030 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B4918_RS22055 ENOG4105UIN B4918_RS22105 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS22120 ENOG4108HGU Histidine kinase B4918_RS22130 ENOG4105CHM Aminotransferase B4918_RS22135 ENOG4105FKQ transcriptional regulator B4918_RS22140 ENOG4105EG2 ABC transporter, permease B4918_RS22150 ENOG4107FKK extracellular solute-binding protein family 1 B4918_RS22160 ENOG4105CG3 alpha amylase, catalytic region B4918_RS22205 ENOG4105CHU acetyl-coa acetyltransferase B4918_RS22240 ENOG4105K7K Transcriptional regulator B4918_RS22245 ENOG4105DTD Dehydrogenase B4918_RS22265 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B4918_RS22290 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B4918_RS22305 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B4918_RS22315 ENOG4105BZU Histidine kinase B4918_RS22335 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B4918_RS22350 ENOG4105CID antiterminator B4918_RS22360 ENOG4105FDP GntR family transcriptional regulator B4918_RS22370 ENOG4105CE4 GlcNAc 6-P deacetylase B4918_RS22410 ENOG4107ZE5 PPIases accelerate the folding of proteins B4918_RS22415 ENOG4105PTM secreted protein B4918_RS22420 ENOG4105J7I hydrolase B4918_RS22430 ENOG4105G6R Stage v sporulation protein ae B4918_RS22440 ENOG4105CZ3 stage V sporulation protein ad B4918_RS22445 ENOG41090VF Stage v sporulation protein ac B4918_RS22465 ENOG4105C8J )-transporter B4918_RS22470 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS22480 ENOG41082AN stage II sporulation protein B4918_RS22485 ENOG4105DZ1 carboxypeptidase B4918_RS22495 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B4918_RS22500 ENOG4105DVE abc transporter atp-binding protein B4918_RS22535 ENOG4105D7N magnesium and cobalt transport protein CorA B4918_RS22560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS22570 ENOG4105I3K Ferric uptake regulator, Fur family B4918_RS22575 ENOG4105MZ9 stage II sporulation protein m B4918_RS22595 ENOG4105CPC Aldo Keto reductase B4918_RS22605 ENOG4105RHY Pfam:UPF0157 B4918_RS22625 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B4918_RS22635 ENOG4105ETE Transcriptional regulator (LacI family B4918_RS22640 ENOG4108YM7 Gcn5-related n-acetyltransferase B4918_RS22660 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B4918_RS22665 ENOG4108R6K riboflavin synthase, subunit alpha B4918_RS22690 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_RS22695 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_RS22710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_RS22725 ENOG4105DFD Na H antiporter B4918_RS22730 ENOG4105CGH 5'-nucleotidase B4918_RS22755 ENOG4105DBV ornithine carbamoyltransferase B4918_RS22770 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B4918_RS22785 ENOG4108IXY short-chain dehydrogenase reductase B4918_RS22790 ENOG41069FQ Metallo-beta-lactamase superfamily B4918_RS22795 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_RS22800 ENOG4105EJQ L-serine dehydratase B4918_RS22830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B4918_RS22845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B4918_RS22850 ENOG4105D9U N-acetyltransferase B4918_RS22865 ENOG4108VZI ErfK ybiS ycfS ynhG family protein B4918_RS22870 ENOG4108QEG Membrane B4918_RS22875 ENOG4105CDA abc transporter atp-binding protein B4918_RS22880 ENOG4105E5Q amino acid AbC transporter B4918_RS22885 ENOG4108HW3 (ABC) transporter B4918_RS22895 ENOG4105G7B Protein of unknown function (DUF2992) B4918_RS22905 ENOG4108QY0 Membrane B4918_RS22920 ENOG4105C7S Dehydrogenase B4918_RS22925 ENOG4105CPP Dehydrogenase, E1 component B4918_RS22945 ENOG4107RDP Dehydrogenase B4918_RS22960 ENOG4108JUB Transcriptional regulator B4918_RS22970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B4918_RS22985 ENOG4107QQR Sporulation B4918_RS22995 ENOG4105S1Z Stage IV sporulation protein B B4918_RS23000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B4918_RS23005 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B4918_RS23010 ENOG4105DX0 Hemolysin A B4918_RS23020 ENOG4105CTB Polyprenyl synthetase B4918_RS23045 ENOG4108ZSR alkaline shock protein B4918_RS23050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B4918_RS23075 ENOG410644B Stage III sporulation protein af B4918_RS23085 ENOG4105KQ4 Stage iii sporulation protein ad B4918_RS23090 ENOG4108CQH stage III sporulation protein AC B4918_RS23095 ENOG4105KR5 Stage iii sporulation protein B4918_RS23100 ENOG4105CD2 stage iii sporulation protein aa B4918_RS23125 ENOG4105DC7 peptidase M24 B4918_RS23130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B4918_RS23140 ENOG4105CBJ Metal-dependent enzyme B4918_RS23150 ENOG4107YBY Hydrolase B4918_RS23180 ENOG41082GG biotin lipoate A B protein ligase B4918_RS23185 ENOG4105WZW rhodanese family B4918_RS23210 ENOG41080TC multidrug resistance protein B4918_RS23260 ENOG4105C0D helicase B4918_RS23350 ENOG4107R6U sodium dicarboxylate symporter B4918_RS23385 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B4918_RS23390 ENOG4105C3R Methionine synthase B4918_RS23400 ENOG4105C28 cystathionine B4918_RS23405 ENOG4105C28 cystathionine B4918_RS23425 ENOG4105C5X domain protein B4918_RS23435 ENOG4105DKQ ROK family B4918_RS23445 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B4918_RS23460 ENOG4108UTW Plays a role in the regulation of phosphate uptake B4918_RS23465 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B4918_RS23470 ENOG4105C8U phosphate abc transporter B4918_RS23475 ENOG4105C8U phosphate abc transporter B4918_RS23485 ENOG4107RF6 penicillin-binding protein B4918_RS23495 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_RS23520 ENOG4105N80 Ferric uptake regulator, Fur family B4918_RS23530 ENOG4105FDK ABC transporter B4918_RS23535 ENOG4108JYZ YitT family B4918_RS23540 ENOG41069ZM Protein of unknown function (DUF2624) B4918_RS23565 ENOG4105EGD dinuclear metal center protein, YbgI family B4918_RS23580 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS23585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B4918_RS23620 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B4918_RS23625 ENOG4105KG3 cytidine deaminase B4918_RS23630 ENOG4107YR5 Diacylglycerol kinase B4918_RS23640 ENOG4105CTJ Metal Dependent Phosphohydrolase B4918_RS23645 ENOG4105C9A Phoh family B4918_RS23655 ENOG41068P3 sporulation protein YqfC B4918_RS23665 ENOG4105KTH gatB Yqey B4918_RS23675 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B4918_RS23680 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B4918_RS23710 ENOG4105CSA Coproporphyrinogen iii oxidase B4918_RS23715 ENOG4105KVH Transcriptional regulator B4918_RS23740 ENOG4105TQK DNA polymerase iii, delta' subunit B4918_RS23750 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B4918_RS23755 ENOG4108UK2 deaminase B4918_RS23760 ENOG4105KQC Competence protein B4918_RS23775 ENOG4105DXX methyltransferase B4918_RS23785 ENOG4108WF2 Metal Dependent Phosphohydrolase B4918_RS23795 ENOG410812S Rna-binding protein B4918_RS23805 ENOG4105CQW ribosome biogenesis GTPase YqeH B4918_RS23810 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B4918_RS23825 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS23845 ENOG4108TVJ Nitroreductase B4918_RS23860 ENOG4105G6Z alkaline phosphatase B4918_RS23865 ENOG4105KEG ribosomal-protein-alanine acetyltransferase B4918_RS23870 ENOG4108MUZ hydrolase B4918_RS23905 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B4918_RS23910 ENOG4105MIR Phenylalanine 4-monooxygenase B4918_RS23920 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_RS23960 ENOG4105S6R Iron-hydroxamate transporter permease subunit B4918_RS23965 ENOG4108V5C ABC transporter B4918_RS23980 ENOG4108EKI Dehydrogenase B4918_RS23985 ENOG4105C28 cystathionine B4918_RS24015 ENOG4107XRG penicillin-binding protein B4918_RS24025 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B4918_RS24035 ENOG4105CFP Peptidase U32 B4918_RS24040 ENOG4105XYU peptidase (U32 family) B4918_RS24045 ENOG4108VQJ O-methyltransferase B4918_RS24050 ENOG4105HHA aminodeoxychorismate lyase B4918_RS24070 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_RS24080 ENOG4105C02 permease B4918_RS24095 ENOG41060CR B4918_RS24100 ENOG4105C7H Helicase, RecD TraA family B4918_RS24110 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B4918_RS24115 ENOG4105C3J Cysteine desulfurase B4918_RS24125 ENOG4105D1H recombination factor protein RarA B4918_RS24130 ENOG4108VCI transcription factor, rsfa family B4918_RS24140 ENOG4105CUZ uba thif-type nad fad binding protein B4918_RS24155 ENOG4105CUT histidyl-tRNA synthetase B4918_RS24175 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B4918_RS24185 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B4918_RS24190 ENOG41076HS cation diffusion facilitator family transporter B4918_RS24195 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B4918_RS24205 ENOG4105CKP Polysaccharide Biosynthesis Protein B4918_RS24210 ENOG4108QG2 Membrane B4918_RS24220 ENOG4105VIE preprotein translocase, subunit YajC B4918_RS24235 ENOG41061AI Protein of unknown function (DUF2905) B4918_RS24250 ENOG4108HUF Transporter B4918_RS24280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B4918_RS24285 ENOG4108IYU L-aspartate oxidase B4918_RS24300 ENOG4108RPX mosc domain containing protein B4918_RS24310 ENOG4105CQC Prephenate dehydratase B4918_RS24330 ENOG4105EWM Histidine kinase B4918_RS24355 ENOG4105X36 (ribosomal) protein B4918_RS24365 ENOG4105C03 ribonuclease B4918_RS24380 ENOG4107QMS site-determining protein B4918_RS24395 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B4918_RS24400 ENOG4105DFF Rod shape-determining protein mreb B4918_RS24430 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS24630 ENOG4108C33 Resolvase B4918_RS24650 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B4918_RS24655 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B4918_RS24665 ENOG41068KH stage VI sporulation protein D B4918_RS24675 ENOG4105D52 delta-aminolevulinic acid dehydratase B4918_RS24700 ENOG4105K56 Transcriptional regulator B4918_RS24720 ENOG4108IUQ atp-dependent protease B4918_RS24750 ENOG4108QCI YvbH-like oligomerisation region B4918_RS24805 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS24825 ENOG4105M59 Phosphodiesterase, mj0936 family B4918_RS24840 ENOG4108XJQ germination protein B4918_RS24850 ENOG4108PCX Major Facilitator B4918_RS24860 ENOG4105KBX Transcriptional regulator, TetR family B4918_RS24870 ENOG4105PFC Transcriptional regulator B4918_RS24880 ENOG4105DZC cytosine deaminase B4918_RS24885 ENOG41067S9 phage shock protein C, PspC B4918_RS24890 ENOG4108JCI Transcriptional regulator B4918_RS24905 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS24915 ENOG4108Z40 Transcriptional regulator B4918_RS24920 ENOG4105RHA ABC transporter, permease B4918_RS24925 ENOG4108IUX (ABC) transporter B4918_RS24930 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family B4918_RS24935 ENOG4105ER2 Ompa motb domain protein B4918_RS24940 ENOG4105E14 MotA TolQ exbB proton channel B4918_RS24945 ENOG4108VXD carboxy-peptidase B4918_RS24955 ENOG4105E33 succinate dehydrogenase B4918_RS24965 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B4918_RS24980 ENOG4105K63 Thioredoxin B4918_RS24985 ENOG4105C10 Electron transfer flavoprotein B4918_RS24990 ENOG4105BZJ Electron transfer flavoprotein B4918_RS24995 ENOG41060WC Enoyl-CoA hydratase B4918_RS25000 ENOG4107Z3H Transcriptional regulator, TetR family B4918_RS25005 ENOG4105CEY Amp-dependent synthetase and ligase B4918_RS25015 ENOG4105J76 Periplasmic binding protein B4918_RS25020 ENOG4105S6R Iron-hydroxamate transporter permease subunit B4918_RS25060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_RS25075 ENOG4105DR4 Methyltransferase B4918_RS25085 ENOG4105KFN sortase, SrtB family B4918_RS25090 ENOG4105E0A ABC, transporter B4918_RS25105 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) B4918_RS25115 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) B4918_RS25125 ENOG4105FE9 pseudouridine synthase B4918_RS25140 ENOG4105DCG PHP domain protein B4918_RS25155 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B4918_RS25170 ENOG4105C5S asparaginyl-tRNA synthetase B4918_RS25175 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B4918_RS25185 ENOG4108RWN rrna methyltransferase B4918_RS25210 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_RS25215 ENOG4105CW7 secretion protein, HlyD family B4918_RS25220 ENOG4108JGH Tetr family transcriptional regulator B4918_RS25225 ENOG4105CN9 Peptidase m42 family protein B4918_RS25245 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B4918_RS25250 ENOG4105C22 threonyL-tRNA synthetase B4918_RS25255 ENOG4108TDW sporulation protein YtxC B4918_RS25280 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B4918_RS25290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B4918_RS25295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B4918_RS25305 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B4918_RS25310 ENOG4105C2M dna polymerase I B4918_RS25315 ENOG4105BZU Histidine kinase B4918_RS25320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_RS25350 ENOG4108HMX isocitrate dehydrogenase (NADP) B4918_RS25355 ENOG4105BZN citrate synthase B4918_RS25370 ENOG4108REF Sporulation integral membrane protein ytvi B4918_RS25375 ENOG4105FS0 cytoplasmic membrane protein B4918_RS25400 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B4918_RS25405 ENOG4105C6K Malic enzyme B4918_RS25410 ENOG4105C0B DNA polymerase III (alpha subunit) B4918_RS25415 ENOG4105VV2 B4918_RS25425 ENOG4105SFS phosphoesterase RecJ domain protein B4918_RS25455 ENOG4105DC7 peptidase M24 B4918_RS25485 ENOG4105Z7P Acetyltransferase (GNAT) family B4918_RS25490 ENOG41082W1 Cupin 2, conserved barrel domain protein B4918_RS25510 ENOG4107YZX Universal stress protein B4918_RS25565 ENOG4108JYZ YitT family B4918_RS25585 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B4918_RS25595 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B4918_RS25600 ENOG4105KBJ sporulation protein ytfj B4918_RS25615 ENOG4105EFZ amidohydrolase B4918_RS25625 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B4918_RS25650 ENOG4107RSM transcriptional regulator B4918_RS25660 ENOG4105U5Y Transcriptional regulator B4918_RS25670 ENOG4105C28 cystathionine B4918_RS25790 ENOG4108UW5 maltose o-acetyltransferase B4918_RS25800 ENOG4105F1V Acetoin utilization protein B4918_RS25805 ENOG4105W87 Cbs domain B4918_RS25810 ENOG4105DGU Histone deacetylase B4918_RS25825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_RS25830 ENOG4105BZU Histidine kinase B4918_RS25835 ENOG4107SNB ankyrin repeat protein YahD B4918_RS25840 ENOG4105EP9 oxidoreductase B4918_RS25870 ENOG4105ETE Transcriptional regulator (LacI family B4918_RS25890 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B4918_RS25910 ENOG4105C88 aminopeptidase B4918_RS25930 ENOG4108IPJ Membrane B4918_RS25965 ENOG4108VDD TRNA binding domain protein B4918_RS25995 ENOG4105C8F Beta-lactamase domain protein B4918_RS26010 ENOG4108V15 phosphotransferase enzyme family B4918_RS26015 ENOG4108IUM Glycogen debranching enzyme B4918_RS26030 ENOG4107QSE Dipeptidase B4918_RS26035 ENOG4105YW5 deoR family transcriptional regulator B4918_RS26050 ENOG4105CBX hi0933 family B4918_RS26095 ENOG4108VJ1 Transcriptional regulator (CarD family B4918_RS26100 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B4918_RS26105 ENOG4105CSC Glucose uptake protein B4918_RS26120 ENOG4108ZAF Molybdopterin B4918_RS26125 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B4918_RS26130 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_RS26140 ENOG4105D06 uba thif-type nad fad binding protein B4918_RS26145 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B4918_RS26170 ENOG41085GJ domain protein B4918_RS26180 ENOG4105DWV Homoserine O-trans-acetylase B4918_RS26220 ENOG410605W Major Facilitator B4918_RS26225 ENOG4107S91 Sodium hydrogen exchanger B4918_RS26230 ENOG4105NCW Trka-c domain protein B4918_RS26265 ENOG4105N5T Radical SAM Protein B4918_RS26295 ENOG4105E8V Alpha Beta Hydrolase Fold protein B4918_RS26300 ENOG4108Z0R Transferase B4918_RS26305 ENOG4105YVM Phosphoesterase, PA-phosphatase related B4918_RS26310 ENOG4105BZF Glycosyl transferase (Group 1 B4918_RS26320 ENOG4105EPU Molybdenum cofactor synthesis domain protein B4918_RS26410 ENOG4105BZU Histidine kinase B4918_RS26415 ENOG4105BZU Histidine kinase B4918_RS26420 ENOG4105CH6 catalase B4918_RS26425 ENOG4107S9D Alpha beta hydrolase B4918_RS26430 ENOG4107T7U Sulfatase B4918_RS26455 ENOG4105D2X ABC transporter substrate-binding protein B4918_RS26465 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B4918_RS26525 ENOG41080TC multidrug resistance protein B4918_RS26530 ENOG410839T multidrug resistance protein B4918_RS26550 ENOG4108V2W Carbonate dehydratase B4918_RS26555 ENOG4105C4M (Ubiquinol oxidase) subunit I B4918_RS26560 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B4918_RS26605 ENOG41087YS Phage shock protein A B4918_RS26630 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B4918_RS26635 ENOG4105BZU Histidine kinase B4918_RS26640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS26665 ENOG4108UGV hypoxanthine phosphoribosyltransferase B4918_RS26670 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B4918_RS26715 ENOG4107ZTW SNARE associated Golgi B4918_RS26730 ENOG4105C19 ABC transporter B4918_RS26745 ENOG4105CJ1 ABC, transporter B4918_RS26755 ENOG41082BM Transcriptional regulator, arsr family B4918_RS26800 ENOG4105C6Z Gluconate B4918_RS26805 ENOG4105FDP GntR family transcriptional regulator B4918_RS26825 ENOG41069H0 dihydroorotase EC 3.5.2.3 B4918_RS26850 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_RS26860 ENOG4108IPT Naphthoate synthase B4918_RS26865 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B4918_RS26875 ENOG4105E4F Isochorismate synthase B4918_RS26880 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B4918_RS26890 ENOG4105VEQ Cold shock protein B4918_RS26935 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B4918_RS26960 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_RS26965 ENOG4108Q5F Tetr family transcriptional regulator B4918_RS27105 ENOG4105KT7 mgtC SapB transporter B4918_RS27110 ENOG4107PBV potassium channel B4918_RS27130 ENOG4105WG9 Conserved Protein B4918_RS27140 ENOG4105CHM Aminotransferase B4918_RS27145 ENOG4108ZB6 transcriptional regulator AsnC family B4918_RS27150 ENOG4105C5I Dehydrogenase B4918_RS27155 ENOG4108MUZ hydrolase B4918_RS27165 ENOG4105C87 Aminotransferase class I and II B4918_RS27180 ENOG4105Y38 Kinase-associated protein B B4918_RS27190 ENOG4107R3E Citrate transporter B4918_RS27210 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) B4918_RS27215 ENOG4105KA0 thioesterase Superfamily protein B4918_RS27230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B4918_RS27250 ENOG41069ER domain protein B4918_RS27265 ENOG4105CEP NADH dehydrogenase B4918_RS27290 ENOG4105EWC Purine nucleoside phosphorylase B4918_RS27315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B4918_RS27340 ENOG4108JJA ABC, transporter B4918_RS27345 ENOG4105C4B ABC transporter, permease B4918_RS27350 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA B4918_RS27405 ENOG41083MR nifu domain-containing protein B4918_RS27420 ENOG4108W5N phosphatidylglycerophosphatase a B4918_RS27440 ENOG4105DAX Pfam:DUF2983 B4918_RS27450 ENOG4105DYS nad(p)h dehydrogenase (quinone) B4918_RS27455 ENOG4105D4U had-superfamily hydrolase, subfamily iia B4918_RS27470 ENOG4105CBT Fructose-1,6-bisphosphatase B4918_RS27490 ENOG4105MMD transcriptional regulator B4918_RS27495 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B4918_RS27500 ENOG4107TXC Transcriptional regulator B4918_RS27505 ENOG41090T1 Membrane B4918_RS27530 ENOG4105FAA peptidase M23 B4918_RS27535 ENOG4108YTE sporulation protein YunB B4918_RS27540 ENOG4105KZD Domain of unknown function (DUF1805) B4918_RS27545 ENOG4107R8B 5'-nucleotidase B4918_RS27580 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_RS27585 ENOG4105XSJ toxin secretion phage lysis holin B4918_RS27725 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_RS27805 ENOG4106050 phage regulatory protein, rha family B4918_RS27820 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B4918_RS27825 ENOG4105VTR Integrase B4918_RS27830 ENOG4105DIW FeS assembly protein SUFB B4918_RS27835 ENOG4108UNV SUF system FeS assembly protein, NifU family B4918_RS27840 ENOG4105C9B Cysteine desulfurase B4918_RS27845 ENOG4105JRK feS assembly protein SufD B4918_RS27850 ENOG4105C3K feS assembly ATPase SufC B4918_RS27855 ENOG4105D01 (LipO)protein B4918_RS27860 ENOG4105D01 (LipO)protein B4918_RS27865 ENOG4108UMI ABC transporter, permease B4918_RS27870 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_RS27895 ENOG41080E8 Transcriptional regulator, Spx MgsR family B4918_RS27915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_RS27940 ENOG4108W8B Beta-lactamase domain protein B4918_RS27945 ENOG4105C1G acyl-Coa dehydrogenase B4918_RS27950 ENOG4105CHU acetyl-coa acetyltransferase B4918_RS27965 ENOG4105DZ1 carboxypeptidase B4918_RS27985 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B4918_RS28000 ENOG4108SUT Major Facilitator Superfamily B4918_RS28005 ENOG4107R7I amino acid B4918_RS28020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B4918_RS28030 ENOG4107AYK membrAne B4918_RS28070 ENOG4107ZTW SNARE associated Golgi B4918_RS28080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B4918_RS28085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS28115 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS28120 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS28125 ENOG4105VG1 fes assembly suf system protein B4918_RS28130 ENOG4105D4Y metalloprotease B4918_RS28135 ENOG4105C2I pirin domain protein B4918_RS28150 ENOG4107T5V SNARE associated Golgi B4918_RS28155 ENOG4107S91 Sodium hydrogen exchanger B4918_RS28160 ENOG4105NCW Trka-c domain protein B4918_RS28175 ENOG4108RMU ferritin dps family protein B4918_RS28195 ENOG4108URH decarboxylase B4918_RS28205 ENOG41090A1 ferritin B4918_RS28215 ENOG4105DHF Membrane B4918_RS28220 ENOG4105D9N nucleoside B4918_RS28225 ENOG4105D9N nucleoside B4918_RS28240 ENOG4108RYK Nad-dependent epimerase dehydratase B4918_RS28260 ENOG4105CV8 reductase B4918_RS28265 ENOG4105F27 Major Facilitator B4918_RS28270 ENOG4105KVH Transcriptional regulator B4918_RS28290 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B4918_RS28295 ENOG4105D4A Cell wall formation (By similarity) B4918_RS28305 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS28315 ENOG4105WMR Protein CrcB homolog B4918_RS28320 ENOG4105WMR Protein CrcB homolog B4918_RS28340 ENOG4105C5H ABC transporter B4918_RS28345 ENOG4108MK9 spermidine N(1)-acetyltransferase B4918_RS28350 ENOG4108VY7 phosphate-starvation-inducible protein PsiE B4918_RS28360 ENOG4108W2Y isochorismatase B4918_RS28380 ENOG4108V2W Carbonate dehydratase B4918_RS28385 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) B4918_RS28405 ENOG4108IPW abc transporter atp-binding protein B4918_RS28410 ENOG4105CM4 permease protein B4918_RS28505 ENOG4105DUX Transporter B4918_RS28545 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B4918_RS28555 ENOG4105XZU Preprotein translocase, subunit SecG B4918_RS28560 ENOG41067MG lrgb family B4918_RS28610 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS28625 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B4918_RS28630 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_RS28635 ENOG4105XSJ toxin secretion phage lysis holin B4918_RS28775 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_RS28850 ENOG4106050 phage regulatory protein, rha family B4918_RS28875 ENOG4105VTR Integrase B4918_RS28895 ENOG41090VF Stage v sporulation protein ac B4918_RS28900 ENOG4105CZ3 stage V sporulation protein ad B4918_RS28915 ENOG4108QY0 Membrane B4918_RS28920 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_RS28930 ENOG4105KRI phosphocarrier protein (HPr B4918_RS28940 ENOG4105CHW UPF0052 protein B4918_RS28950 ENOG4108Z4K mutator MutT protein B4918_RS28960 ENOG4105C3M thioredoxin reductase B4918_RS28970 ENOG4108S4C acetyltransferase B4918_RS28990 ENOG41086DT Membrane protein of unknown function B4918_RS29000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B4918_RS29020 ENOG4107TXC Transcriptional regulator B4918_RS29035 ENOG4105HMI Membrane B4918_RS29040 ENOG4105DUM transcriptional regulator, lysR family B4918_RS29050 ENOG4108WS4 fmn reductase B4918_RS29055 ENOG4105C5H ABC transporter B4918_RS29065 ENOG4105BZ1 (ABC) transporter B4918_RS29075 ENOG4105CN1 protease B4918_RS29080 ENOG4105CRP Part of the ABC transporter FtsEX involved in B4918_RS29085 ENOG4105CAK Cell division ATP-binding protein ftsE B4918_RS29115 ENOG4105MS2 ribosomal subunit Interface protein B4918_RS29120 ENOG4105VEQ Cold shock protein B4918_RS29125 ENOG41081UC Inherit from COG: Competence protein B4918_RS29140 ENOG4105KVH Transcriptional regulator B4918_RS29155 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B4918_RS29160 ENOG4108KGH TRANSCRIPTIONal B4918_RS29165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B4918_RS29170 ENOG4105C6Y Udp-glucose 6-dehydrogenase B4918_RS29175 ENOG4105ESV Glycosyl transferase, family 4 B4918_RS29185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B4918_RS29210 ENOG4105F8D glycoside hydrolase family 4 B4918_RS29215 ENOG4105VCP PTS System B4918_RS29220 ENOG4105CK1 PTS System B4918_RS29230 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B4918_RS29235 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B4918_RS29240 ENOG4105VCP PTS System B4918_RS29255 ENOG4105VZJ PTS System B4918_RS29280 ENOG4105ECB domain protein B4918_RS29285 ENOG4107RSM transcriptional regulator B4918_RS29320 ENOG4105DAA L-lactate B4918_RS29330 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) B4918_RS29345 ENOG4105E0M Sulfatase B4918_RS29380 ENOG4107R8N Glycosyl transferase, family 2 B4918_RS29390 ENOG4105C94 Transporter B4918_RS29400 ENOG41069ER domain protein B4918_RS29425 ENOG4105KBK Zinc finger, swim domain protein B4918_RS29430 ENOG4105C0D helicase B4918_RS29440 ENOG41085W3 Transposase B4918_RS29470 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_RS29480 ENOG4107RBB ABC transporter, permease B4918_RS29485 ENOG4105C19 ABC transporter B4918_RS29495 ENOG4105CXY transporter B4918_RS29510 ENOG4105BZU Histidine kinase B4918_RS29515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS29520 ENOG4105CMR udp-glucose 4-epimerase B4918_RS29525 ENOG4105CMR udp-glucose 4-epimerase B4918_RS29535 ENOG4108KGH TRANSCRIPTIONal B4918_RS29545 ENOG4105C6Y Udp-glucose 6-dehydrogenase B4918_RS29560 ENOG4107T8Q Glycosyl transferase (Group 1 B4918_RS29565 ENOG4105K64 Glycosyl transferase, family 2 B4918_RS29570 ENOG4108PQP glycosyl transferase group 1 B4918_RS29585 ENOG4105D3Q Sugar transferase B4918_RS29590 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_RS29600 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B4918_RS29605 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B4918_RS29610 ENOG4107YJ4 chain length determinant protein B4918_RS29615 ENOG4105HTX biosynthesis protein B4918_RS29620 ENOG4107YJ4 chain length determinant protein B4918_RS29635 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B4918_RS29645 ENOG4105FRN stage II sporulation protein B4918_RS29660 ENOG4105DY9 regulatoR B4918_RS29680 ENOG4106778 Protein of unknown function (DUF1146) B4918_RS29685 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B4918_RS29690 ENOG4105C8S subunit m B4918_RS29695 ENOG4105D65 subunit l B4918_RS29720 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B4918_RS29725 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B4918_RS29735 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B4918_RS29740 ENOG4105BZU Histidine kinase B4918_RS29795 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B4918_RS29800 ENOG41062M3 atp synthase B4918_RS29825 ENOG4108UIC UPF0340 protein B4918_RS29830 ENOG4108YZG isomerase B4918_RS29850 ENOG4108VGI doxx family B4918_RS29855 ENOG4107XC4 flavin reductase domain protein, FMN-binding B4918_RS29875 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B4918_RS29885 ENOG4108ZXQ stage ii sporulation protein r B4918_RS29890 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B4918_RS29895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B4918_RS29915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B4918_RS29920 ENOG4105CBT Fructose-1,6-bisphosphatase B4918_RS29930 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B4918_RS29970 ENOG4105C1G acyl-Coa dehydrogenase B4918_RS29975 ENOG4105C1G acyl-Coa dehydrogenase B4918_RS29980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B4918_RS29990 ENOG4105DF6 Fe-S oxidoreductase B4918_RS30005 ENOG4105BZU Histidine kinase B4918_RS30030 ENOG4105BZU Histidine kinase B4918_RS30035 ENOG4105KCT ABC transporter B4918_RS30040 ENOG4108M15 ABC transporter B4918_RS30045 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B4918_RS30055 ENOG4105IIU Aminopeptidase B4918_RS30080 ENOG410684U Domain of unknown function (DUF1934) B4918_RS30105 ENOG4105CYW agmatinase B4918_RS30115 ENOG4105DXB Major Facilitator superfamily B4918_RS30120 ENOG4107SWG transcriptional regulator MERR family B4918_RS30125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B4918_RS30130 ENOG4105BZ4 penicillin-binding protein B4918_RS30135 ENOG4108XFG YwhD family B4918_RS30140 ENOG4108Z4T Peptidase M50 B4918_RS30145 ENOG41069HH 4-oxalocrotonate tautomerase B4918_RS30150 ENOG4105DCI Phosphohydrolase B4918_RS30155 ENOG4108MES Periplasmic binding protein B4918_RS30160 ENOG4105E0A ABC, transporter B4918_RS30165 ENOG4105EHG Permease protein B4918_RS30170 ENOG4105DQ5 transport system permease protein B4918_RS30180 ENOG4108VCI transcription factor, rsfa family B4918_RS30185 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B4918_RS30190 ENOG4108IJ2 phosphate acetyltransferase B4918_RS30195 ENOG4107UEZ chlorite dismutase B4918_RS30205 ENOG4108VKI Cell wall hydrolase B4918_RS30225 ENOG4107SVH Potassium channel protein B4918_RS30235 ENOG410667J hydrolase B4918_RS30240 ENOG4105VCH membrane B4918_RS30250 ENOG4108TU7 Inherit from COG: (ABC) transporter B4918_RS30255 ENOG4105CJ1 ABC, transporter B4918_RS30260 ENOG41090WU lipolytic protein G-D-S-L family B4918_RS30275 ENOG4105D6E homoserine dehydrogenase B4918_RS30295 ENOG4108Y4K DNA-binding transcriptional activator B4918_RS30305 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_RS30310 ENOG4105BZU Histidine kinase B4918_RS30315 ENOG4105DWF phosphomethylpyrimidine kinase B4918_RS30320 ENOG4105BZU Histidine kinase B4918_RS30325 ENOG4105VCD cytoplasmic protein B4918_RS30330 ENOG4105D22 carbon starvation protein B4918_RS30335 ENOG4105DY9 regulatoR B4918_RS30340 ENOG41079KZ Major Facilitator Superfamily B4918_RS30355 ENOG4105CG5 Glycosyl transferase (Group 1 B4918_RS30365 ENOG4105EN6 Membrane B4918_RS30370 ENOG4106YBV Methyl-accepting chemotaxis B4918_RS30380 ENOG4108S4H thioesterase Superfamily protein B4918_RS30385 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) B4918_RS30400 ENOG4105K64 Glycosyl transferase, family 2 B4918_RS30410 ENOG4105EJV Membrane B4918_RS30415 ENOG4105CKK Glycosyl transferase, family 2 B4918_RS30425 ENOG4108IG5 Transcriptional regulator B4918_RS30430 ENOG4105C5H ABC transporter B4918_RS30435 ENOG41067SE Tetr family transcriptional regulator B4918_RS30445 ENOG4105E0X reductase B4918_RS30450 ENOG4106F5Q Membrane B4918_RS30465 ENOG4108NEV two component transcriptional regulator, LytTR family B4918_RS30470 ENOG4108HRK Histidine kinase B4918_RS30475 ENOG4107RGD Major Facilitator superfamily B4918_RS30495 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_RS30505 ENOG4105IW1 AmiS UreI transporter B4918_RS30520 ENOG4105CMR udp-glucose 4-epimerase B4918_RS30525 ENOG4108UT2 hemolysin iii B4918_RS30535 ENOG4105C1J atp-dependent rna helicase B4918_RS30540 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B4918_RS30545 ENOG4105DPN Oligoendopeptidase f B4918_RS30560 ENOG4105BZU Histidine kinase B4918_RS30575 ENOG4105C0H protease B4918_RS30580 ENOG4105Q2H domain protein B4918_RS30595 ENOG4105BZU Histidine kinase B4918_RS30600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_RS30625 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B4918_RS30630 ENOG4105CDU Replicative dna helicase B4918_RS30640 ENOG4105BZR domain protein B4918_RS30645 ENOG4108XMW Membrane B4918_RS30655 ENOG4108UUM single-stranded DNA-binding protein B4918_RS30665 ENOG4105C3G gtp-binding protein B4918_RS30670 ENOG4105VDK protein, conserved in bacteria B4918_RS30675 ENOG4105D8X mechanosensitive ion channel B4918_RS30680 ENOG4108ZDA Sporulation protein YyaC B4918_RS30685 ENOG4105FA0 parb-like partition protein B4918_RS30690 ENOG4107QJE Chromosome Partitioning Protein B4918_RS30710 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B4918_RS30720 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B4918_RS30750 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_RS30795 ENOG4108N0N Phage Terminase Large Subunit B4918_RS30925 ENOG41085W3 Transposase B4918_RS30935 ENOG410907Z n-acetylmuramoyl-l-alanine amidase B4918_RS31010 ENOG41067QW Transcriptional regulator B4918_RS31145 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS31325 ENOG4106CGH Phage Mu protein F like protein B4918_RS31330 ENOG4108MDF Phage Portal Protein B4918_RS31345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS31415 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS31475 ENOG4105CFF transcriptional regulator B4918_RS31495 ENOG4108IBT Inherit from COG: transposase B4918_RS31515 ENOG4105D9P serine threonine protein kinase B4918_RS31575 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B4918_RS31580 ENOG4105VTR Integrase B4918_RS31655 ENOG4105K70 DNA-binding protein B4918_RS31670 ENOG4107JM4 Tetratricopeptide repeat B4918_RS31700 ENOG4105CAQ asparagine synthetase B4918_RS31705 ENOG4108RZE Tetr family transcriptional regulator B4918_RS31715 ENOG4108IBT Inherit from COG: transposase B4918_RS31740 ENOG4105D7V transposase B4918_RS31765 ENOG4107JM4 Tetratricopeptide repeat B4918_RS31775 ENOG4105YWU small acid-soluble spore protein B4918_RS31880 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS31920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_RS31925 ENOG4105VIZ double-strand break repair protein B4918_RS31975 ENOG4105CNU cell division protein FtsK B4918_RS32175 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS32235 ENOG4105DHF Membrane B4918_RS32335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B4918_RS32375 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS32405 ENOG4105KRN Transcriptional regulator, abrb family B4918_RS32410 ENOG4108J59 Extracellular solute-binding protein, family 5 B4918_RS32425 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_RS32440 ENOG4108IBT Inherit from COG: transposase B4918_RS32505 ENOG4108MES Periplasmic binding protein B4918_RS32515 ENOG4105C8Q Methyl-accepting chemotaxis B4918_RS32520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_RS32530 ENOG4108BSC Methyltransferase B4918_RS32535 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B4918_RS32540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_RS32545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_RS32550 ENOG4105C3U ABC transporter B4918_RS32555 ENOG4108JQ7 (ABC) transporter B4918_RS32575 ENOG4105ES4 Nitrilase B4918_RS32585 ENOG4107RF6 penicillin-binding protein B4918_RS32620 ENOG4105T38 integral membrane protein B4918_RS32625 ENOG4107VMI polysaccharide deacetylase B4918_RS32655 ENOG4105EJQ L-serine dehydratase B4918_RS32660 ENOG4105C44 Serine transporter B4918_RS32710 ENOG4105F6S Spore photoproduct lyase B4918_RS32790 ENOG4107QHE Choloylglycine hydrolase B4918_RS32795 ENOG4105FQP Beta-lactamase B4918_RS32800 ENOG4105CNI cell division protein FtsW B4918_RS32810 ENOG4105CJW magnesium transporter B4918_RS32880 ENOG4105D13 transposase B4918_RS32900 ENOG4107ZTW SNARE associated Golgi B4918_RS32915 ENOG4108D32 Methyltransferase B4918_RS32950 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS32995 ENOG4105NCW Trka-c domain protein B4918_RS33000 ENOG4107S91 Sodium hydrogen exchanger B4918_RS33005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS33050 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS33080 ENOG4105XSJ toxin secretion phage lysis holin B4918_RS33110 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_RS33120 ENOG4107DUR UPF0457 protein B4918_RS33215 ENOG4105K70 DNA-binding protein B4918_RS33335 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS33345 ENOG4105EKQ RNA-directed DNA polymerase B4918_RS33365 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_RS33655 ENOG4105JAB phenazine biosynthesis protein, phzf family