locus-tag class description FOC85_RS00030 ENOG41060SN FOC85_RS00115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_RS00155 ENOG4107QJE Chromosome Partitioning Protein FOC85_RS00220 ENOG4105WXW Antirepressor FOC85_RS00250 ENOG4106CVF DNA replication protein FOC85_RS00325 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC85_RS00350 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC85_RS00355 ENOG4108TFU terminase (Small subunit) FOC85_RS00365 ENOG4108MDF Phage Portal Protein FOC85_RS00370 ENOG4106CGH Phage Mu protein F like protein FOC85_RS00405 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS00410 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS00420 ENOG4107258 Transcriptional regulator FOC85_RS00430 ENOG4105E0Y RtcB Protein FOC85_RS00435 ENOG4105ECK Fatty Acid Desaturase FOC85_RS00450 ENOG4105VMP Transcriptional regulator FOC85_RS00465 ENOG41090T1 Membrane FOC85_RS00475 ENOG4108WCX response regulator FOC85_RS00485 ENOG41068WN FOC85_RS00525 ENOG4105CSH Transporter FOC85_RS00535 ENOG4105CKK Glycosyl transferase, family 2 FOC85_RS00550 ENOG4105CKK Glycosyl transferase, family 2 FOC85_RS00560 ENOG4105C8Y Acetylornithine aminotransferase FOC85_RS00565 ENOG4105CH6 catalase FOC85_RS00605 ENOG4108TVJ Nitroreductase FOC85_RS00610 ENOG4105FS7 Transcriptional regulator FOC85_RS00645 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS00665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_RS00695 ENOG4108XET gCN5-related N-acetyltransferase FOC85_RS00755 ENOG410635A Membrane FOC85_RS00760 ENOG4105KNA -acetyltransferase FOC85_RS00765 ENOG4108IQI permease FOC85_RS00775 ENOG4105F1N DNA alkylation repair FOC85_RS00805 ENOG4107RF6 penicillin-binding protein FOC85_RS00840 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC85_RS00845 ENOG4107258 Transcriptional regulator FOC85_RS00855 ENOG4106N3A copper homeostasis protein cutc FOC85_RS00860 ENOG4108ZRV stage ii sporulation protein p FOC85_RS00865 ENOG4108ZHR arsR family transcriptional regulator FOC85_RS00875 ENOG4105FDT acyl-CoA dehydrogenase FOC85_RS00890 ENOG4105DWD nucleoside recognition domain protein FOC85_RS00985 ENOG4105E2A Dehydrogenase FOC85_RS00995 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_RS01000 ENOG4105HDK L-asparaginase FOC85_RS01005 ENOG4108IMY Transcriptional regulator FOC85_RS01025 ENOG4108B31 Spore germination protein FOC85_RS01060 ENOG41075H3 AraC family transcriptional regulator FOC85_RS01080 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC85_RS01085 ENOG4105CUB amino acid FOC85_RS01090 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS01110 ENOG4105CSV Glutaminase FOC85_RS01145 ENOG4105CGH 5'-nucleotidase FOC85_RS01150 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC85_RS01190 ENOG4108606 TspO/MBR family FOC85_RS01195 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC85_RS01210 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC85_RS01215 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC85_RS01230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC85_RS01240 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC85_RS01245 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC85_RS01255 ENOG4105C19 ABC transporter FOC85_RS01270 ENOG4108NEV two component transcriptional regulator, LytTR family FOC85_RS01275 ENOG4105DSE periplasmic solute binding protein FOC85_RS01280 ENOG4105CC5 ABC transporter FOC85_RS01285 ENOG4105DIK (ABC) transporter FOC85_RS01310 ENOG4105D6J arsenicaL-resistance protein FOC85_RS01315 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_RS01320 ENOG41085FC arsR family transcriptional regulator FOC85_RS01335 ENOG4105F7F Chaperone FOC85_RS01370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC85_RS01375 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS01385 ENOG4105IIP Membrane FOC85_RS01400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS01405 ENOG41062D9 Histidine kinase FOC85_RS01430 ENOG4105K6H D-cysteine desulfhydrase FOC85_RS01455 ENOG4108NNI Beta-lactamase domain-containing protein FOC85_RS01460 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC85_RS01470 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_RS01485 ENOG4105C88 aminopeptidase FOC85_RS01495 ENOG4105W1Y Transcriptional regulator FOC85_RS01500 ENOG4105JQZ Methyltransferase FOC85_RS01520 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC85_RS01535 ENOG4105BZU Histidine kinase FOC85_RS01550 ENOG4108U05 Transcriptional regulator FOC85_RS01555 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC85_RS01565 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC85_RS01580 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC85_RS01595 ENOG4105CEP NADH dehydrogenase FOC85_RS01600 ENOG4105D4Y metalloprotease FOC85_RS01605 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_RS01655 ENOG4105TRI Hydrolase FOC85_RS01695 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_RS01720 ENOG4105C44 Serine transporter FOC85_RS01725 ENOG4105EJQ L-serine dehydratase FOC85_RS01735 ENOG4105MZU cell filamentation protein FOC85_RS01740 ENOG4108JPW Aminotransferase FOC85_RS01755 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC85_RS01765 ENOG4105DVH amino acid FOC85_RS01780 ENOG4108JQ1 Dehydrogenase FOC85_RS01800 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC85_RS01805 ENOG410874W AraC family transcriptional regulator FOC85_RS01820 ENOG4108IBT Inherit from COG: transposase FOC85_RS01835 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_RS01875 ENOG4108ISG Major Facilitator FOC85_RS01885 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC85_RS01890 ENOG4105CZM Major Facilitator FOC85_RS01905 ENOG4105DA5 (ABC) transporter FOC85_RS01910 ENOG41069JR FOC85_RS01920 ENOG4105RXJ FOC85_RS01930 ENOG4105KBX Transcriptional regulator, TetR family FOC85_RS01935 ENOG4107AUC FOC85_RS01945 ENOG4105CRW Short chain fatty acid transporter FOC85_RS01955 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC85_RS01990 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC85_RS02015 ENOG4108K8S endonuclease I FOC85_RS02020 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC85_RS02050 ENOG4105DSE periplasmic solute binding protein FOC85_RS02055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS02075 ENOG4108Z66 YbaK ebsC protein FOC85_RS02085 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_RS02105 ENOG4105KVH Transcriptional regulator FOC85_RS02110 ENOG4108RCM Nitroreductase FOC85_RS02130 ENOG4108PSK reductase FOC85_RS02140 ENOG4105CJ1 ABC, transporter FOC85_RS02175 ENOG4105D7V transposase FOC85_RS02215 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_RS02220 ENOG4105DKQ ROK family FOC85_RS02225 ENOG4106UW1 Major Facilitator superfamily FOC85_RS02230 ENOG4108UW5 maltose o-acetyltransferase FOC85_RS02255 ENOG4105DMQ Methyltransferase FOC85_RS02265 ENOG4105EV4 Multidrug resistance protein mdtH FOC85_RS02295 ENOG4105C37 (CBS) domain FOC85_RS02310 ENOG4105DDN Pentapeptide repeat-containing protein FOC85_RS02315 ENOG4105XDF Protein of unknown function (DUF1272) FOC85_RS02320 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC85_RS02325 ENOG4105CMG Carbohydrate kinase FOC85_RS02330 ENOG4105C6Z Gluconate FOC85_RS02335 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC85_RS02350 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC85_RS02370 ENOG4105C44 Serine transporter FOC85_RS02405 ENOG4108TZY GntR Family Transcriptional Regulator FOC85_RS02410 ENOG4105D9R oxidoreductase FOC85_RS02445 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC85_RS02455 ENOG4105CHR reductase FOC85_RS02465 ENOG4105KNA -acetyltransferase FOC85_RS02475 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC85_RS02480 ENOG4105KVH Transcriptional regulator FOC85_RS02545 ENOG4105KAF membrAne FOC85_RS02595 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC85_RS02610 ENOG4107YXZ hydrolase, family 25 FOC85_RS02645 ENOG4105H3G oxidoreductase FOC85_RS02690 ENOG4105K7K Transcriptional regulator FOC85_RS02695 ENOG4105CIS alcohol dehydrogenase FOC85_RS02730 ENOG4108TN2 lmbE family FOC85_RS02740 ENOG4107R3E Citrate transporter FOC85_RS02755 ENOG4108MES Periplasmic binding protein FOC85_RS02760 ENOG4105EHG Permease protein FOC85_RS02765 ENOG4105DQ5 transport system permease protein FOC85_RS02770 ENOG4105NX3 Membrane FOC85_RS02775 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC85_RS02795 ENOG4107V2S Transcriptional regulator FOC85_RS02815 ENOG4105C98 muts2 protein FOC85_RS02830 ENOG4105E5K Alpha-amylase FOC85_RS02835 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC85_RS02840 ENOG4105DPN Oligoendopeptidase f FOC85_RS02845 ENOG4108A04 Beta-lactamase FOC85_RS02875 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC85_RS02900 ENOG41082BM Transcriptional regulator, arsr family FOC85_RS02905 ENOG4105CIS alcohol dehydrogenase FOC85_RS02940 ENOG4105C09 Bile acid FOC85_RS02945 ENOG4105CQB FAD linked oxidase domain protein FOC85_RS02965 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC85_RS02975 ENOG4105K64 Glycosyl transferase, family 2 FOC85_RS02980 ENOG4105E39 Enoyl-CoA hydratase FOC85_RS02990 ENOG4105KT7 mgtC SapB transporter FOC85_RS03005 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_RS03010 ENOG41073R8 VanW family FOC85_RS03020 ENOG4108R1P FOC85_RS03035 ENOG4105VEQ Cold shock protein FOC85_RS03075 ENOG410904N short-chain dehydrogenase reductase FOC85_RS03085 ENOG4106IQC argininosuccinate lyase FOC85_RS03100 ENOG4108IA2 Sodium pantothenate symporter FOC85_RS03105 ENOG4105RG0 Membrane FOC85_RS03110 ENOG4105C26 Dehydrogenase FOC85_RS03115 ENOG4105CHR reductase FOC85_RS03125 ENOG4105EWU Squalene--hopene cyclase FOC85_RS03135 ENOG4105FR1 rard protein FOC85_RS03140 ENOG410696E Membrane FOC85_RS03155 ENOG4105D1F ATP-binding protein FOC85_RS03165 ENOG4108ZAF Molybdopterin FOC85_RS03170 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC85_RS03175 ENOG4105D06 uba thif-type nad fad binding protein FOC85_RS03180 ENOG4105TMB Formate nitrite transporter FOC85_RS03190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC85_RS03195 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC85_RS03205 ENOG4108JB9 formate dehydrogenase FOC85_RS03210 ENOG4105E1K spore germination protein FOC85_RS03275 ENOG4107QJT sodium dicarboxylate symporter FOC85_RS03280 ENOG4108KGH TRANSCRIPTIONal FOC85_RS03290 ENOG4105EMN RNA polymerase sigma factor FOC85_RS03310 ENOG4105CIG ABC transporter FOC85_RS03320 ENOG4105D9R oxidoreductase FOC85_RS03335 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC85_RS03340 ENOG4105K4P CoA-binding domain protein FOC85_RS03345 ENOG4105C0H protease FOC85_RS03350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS03360 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC85_RS03370 ENOG4105W8X HesB YadR YfhF-family protein FOC85_RS03400 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC85_RS03405 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC85_RS03415 ENOG4108JJA ABC, transporter FOC85_RS03420 ENOG4108I0Z Aconitate hydratase FOC85_RS03460 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC85_RS03480 ENOG4107F3J Amp-dependent synthetase and ligase FOC85_RS03485 ENOG4107ZYJ bioY protein FOC85_RS03490 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_RS03540 ENOG4107AYK membrAne FOC85_RS03550 ENOG4105BZU Histidine kinase FOC85_RS03555 ENOG4105FBA Phospholipase Carboxylesterase FOC85_RS03560 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC85_RS03565 ENOG4105CK7 Sodium proline symporter FOC85_RS03570 ENOG4105CBC glutamate synthase FOC85_RS03575 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC85_RS03580 ENOG4108VJ1 Transcriptional regulator (CarD family FOC85_RS03585 ENOG4108903 Formimidoylglutamase FOC85_RS03610 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC85_RS03655 ENOG4107QIV Cytochrome c biogenesis protein FOC85_RS03675 ENOG4105CJ1 ABC, transporter FOC85_RS03685 ENOG4107RSM transcriptional regulator FOC85_RS03695 ENOG41067MG lrgb family FOC85_RS03720 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_RS03735 ENOG4105BZ1 (ABC) transporter FOC85_RS03740 ENOG4105BZ1 (ABC) transporter FOC85_RS03780 ENOG4105CGH 5'-nucleotidase FOC85_RS03790 ENOG4108SVB resolvase FOC85_RS03810 ENOG4105K7K Transcriptional regulator FOC85_RS03815 ENOG4105C5F glutamine synthetase FOC85_RS03820 ENOG4105KV4 Transcriptional regulator FOC85_RS03825 ENOG4105CXI aluminum resistance protein FOC85_RS03830 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC85_RS03835 ENOG4105EN6 Membrane FOC85_RS03840 ENOG4106F1P AAA ATPase, central domain protein FOC85_RS03870 ENOG41069ER domain protein FOC85_RS03875 ENOG4105DM4 PTS System FOC85_RS03880 ENOG4105DE4 1-phosphofructokinase FOC85_RS03885 ENOG4105E98 transcriptional regulator DeoR family FOC85_RS03890 ENOG4107QW4 alcohol dehydrogenase FOC85_RS03895 ENOG4108SJC Membrane FOC85_RS03905 ENOG4105C85 amino acid FOC85_RS03925 ENOG4105TMB Formate nitrite transporter FOC85_RS03930 ENOG4105K70 DNA-binding protein FOC85_RS03935 ENOG4105C59 p-type ATPase FOC85_RS03940 ENOG410681U heavy metal transport detoxification protein FOC85_RS03945 ENOG4105VPX protein, conserved in bacteria FOC85_RS03965 ENOG4105NIV Esterase FOC85_RS03970 ENOG4105E0A ABC, transporter FOC85_RS03990 ENOG4105CGK Exodeoxyribonuclease III FOC85_RS04000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC85_RS04005 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC85_RS04035 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_RS04040 ENOG4105BZU Histidine kinase FOC85_RS04130 ENOG4105F0V Cell wall hydrolase FOC85_RS04140 ENOG4105E0M Sulfatase FOC85_RS04145 ENOG410890F Dynamin family FOC85_RS04155 ENOG4107QHE Choloylglycine hydrolase FOC85_RS04185 ENOG4105DQU oxidoreductase, subunit beta FOC85_RS04190 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC85_RS04195 ENOG4108IGT Dipeptidase FOC85_RS04200 ENOG4105MCT stage V sporulation protein S FOC85_RS04205 ENOG4105D48 metallophosphoesterase FOC85_RS04225 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC85_RS04240 ENOG4105XZV Protein of unknown function (DUF3243) FOC85_RS04245 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC85_RS04265 ENOG4105UIB (ABC) transporter FOC85_RS04270 ENOG4108JQ9 ABC transporter FOC85_RS04275 ENOG4105DIH basic membrane FOC85_RS04280 ENOG4105FDP GntR family transcriptional regulator FOC85_RS04285 ENOG4107QZI cell division protein FtsK FOC85_RS04295 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC85_RS04305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC85_RS04315 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC85_RS04320 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC85_RS04325 ENOG4105E35 Dipicolinate synthase subunit A FOC85_RS04335 ENOG4105C1V Peptidase, M16 FOC85_RS04355 ENOG4105DTN riboflavin biosynthesis protein ribF FOC85_RS04370 ENOG4105W7A Protein of unknown function (DUF503) FOC85_RS04380 ENOG4105VHM ribosomal protein FOC85_RS04385 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC85_RS04390 ENOG4105CHV Transcription elongation factor NusA FOC85_RS04400 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC85_RS04405 ENOG4105EKQ RNA-directed DNA polymerase FOC85_RS04420 ENOG4105DZP Membrane-associated zinc metalloprotease FOC85_RS04430 ENOG4105KNE Phosphatidate cytidylyltransferase FOC85_RS04475 ENOG4108HE4 integrase family FOC85_RS04485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC85_RS04490 ENOG4105C79 DNA protecting protein DprA FOC85_RS04495 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC85_RS04510 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC85_RS04535 ENOG4105VB6 UPF0109 protein FOC85_RS04555 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC85_RS04560 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC85_RS04575 ENOG4105CHR reductase FOC85_RS04580 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC85_RS04595 ENOG4105CB5 ATP-dependent DNA helicase recG FOC85_RS04600 ENOG4105DP4 dak2 domain fusion protein ylov FOC85_RS04605 ENOG4108ZAA Alkaline-shock protein FOC85_RS04620 ENOG4105FJ0 thiamine FOC85_RS04625 ENOG4105DJV ribulose-phosphate 3-epimerase FOC85_RS04630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC85_RS04635 ENOG4105D9P serine threonine protein kinase FOC85_RS04640 ENOG4108ZF3 Phosphatase FOC85_RS04650 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC85_RS04660 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC85_RS04665 ENOG4105C25 Primosomal protein n' FOC85_RS04670 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC85_RS04690 ENOG4105DSJ YicC domain protein FOC85_RS04705 ENOG4105DC7 peptidase M24 FOC85_RS04795 ENOG4105C34 Pseudouridine synthase FOC85_RS04820 ENOG4105DBK s4 domain protein FOC85_RS04825 ENOG41067XK integral membrane protein FOC85_RS04835 ENOG4105DFA alanine racemase domain protein FOC85_RS04840 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC85_RS04845 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC85_RS04855 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS04865 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC85_RS04870 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC85_RS04875 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC85_RS04880 ENOG4105D4A Cell wall formation (By similarity) FOC85_RS04890 ENOG4105CNI cell division protein FtsW FOC85_RS04905 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC85_RS04910 ENOG4105CJN penicillin-binding protein FOC85_RS04915 ENOG4105CJN penicillin-binding protein FOC85_RS04920 ENOG41068DC Essential cell division protein (By similarity) FOC85_RS04955 ENOG4105KNH Nucleic acid-binding protein FOC85_RS04965 ENOG41063PX domain protein FOC85_RS04970 ENOG4105D78 K07001 NTE family protein FOC85_RS04975 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC85_RS04985 ENOG4106H78 methyltransferase FOC85_RS05005 ENOG4107TB6 phosphoglycerate mutase FOC85_RS05020 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC85_RS05070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC85_RS05075 ENOG4105CNI cell division protein FtsW FOC85_RS05090 ENOG4108IAB Phoh family FOC85_RS05110 ENOG4105QA2 FOC85_RS05115 ENOG4105CI3 gtp-binding protein typa FOC85_RS05125 ENOG4105ECY inositol monophosphatase FOC85_RS05145 ENOG4105CXN decarboxylase FOC85_RS05195 ENOG4105CPP Dehydrogenase, E1 component FOC85_RS05210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC85_RS05215 ENOG4108X4Q Hydrolase FOC85_RS05225 ENOG4105CN5 Metallo-Beta-Lactamase FOC85_RS05230 ENOG4107ZYR domain protein FOC85_RS05265 ENOG4108XRC Protein of unknown function (DUF458) FOC85_RS05275 ENOG4107IN1 Protein of unknown function (DUF1797) FOC85_RS05290 ENOG4105EPM Diguanylate phosphodiesterase FOC85_RS05295 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC85_RS05310 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC85_RS05320 ENOG4105UIN FOC85_RS05375 ENOG4108HGU Histidine kinase FOC85_RS05385 ENOG4105CHM Aminotransferase FOC85_RS05390 ENOG4105FKQ transcriptional regulator FOC85_RS05395 ENOG4105EG2 ABC transporter, permease FOC85_RS05405 ENOG4107FKK extracellular solute-binding protein family 1 FOC85_RS05415 ENOG4105CG3 alpha amylase, catalytic region FOC85_RS05460 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC85_RS05465 ENOG4105CHU acetyl-coa acetyltransferase FOC85_RS05495 ENOG4105K7K Transcriptional regulator FOC85_RS05500 ENOG4105DTD Dehydrogenase FOC85_RS05520 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC85_RS05560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC85_RS05565 ENOG4105BZU Histidine kinase FOC85_RS05585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC85_RS05600 ENOG4105CID antiterminator FOC85_RS05620 ENOG4105CE4 GlcNAc 6-P deacetylase FOC85_RS05655 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC85_RS05660 ENOG4105PTM secreted protein FOC85_RS05665 ENOG4105J7I hydrolase FOC85_RS05675 ENOG4105G6R Stage v sporulation protein ae FOC85_RS05685 ENOG4105CZ3 stage V sporulation protein ad FOC85_RS05690 ENOG41090VF Stage v sporulation protein ac FOC85_RS05710 ENOG4105C8J )-transporter FOC85_RS05715 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS05725 ENOG41082AN stage II sporulation protein FOC85_RS05730 ENOG4105DZ1 carboxypeptidase FOC85_RS05735 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS05740 ENOG4105DVE abc transporter atp-binding protein FOC85_RS05770 ENOG4105D7N magnesium and cobalt transport protein CorA FOC85_RS05795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_RS05805 ENOG4105I3K Ferric uptake regulator, Fur family FOC85_RS05810 ENOG4105MZ9 stage II sporulation protein m FOC85_RS05830 ENOG4105CPC Aldo Keto reductase FOC85_RS05840 ENOG4105RHY Pfam:UPF0157 FOC85_RS05860 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC85_RS05870 ENOG4105ETE Transcriptional regulator (LacI family FOC85_RS05875 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC85_RS05895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC85_RS05900 ENOG4108R6K riboflavin synthase, subunit alpha FOC85_RS05925 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_RS05930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_RS05945 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_RS05955 ENOG4105DFD Na H antiporter FOC85_RS05960 ENOG4105CGH 5'-nucleotidase FOC85_RS06000 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC85_RS06015 ENOG4108IXY short-chain dehydrogenase reductase FOC85_RS06020 ENOG41069FQ Metallo-beta-lactamase superfamily FOC85_RS06025 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS06030 ENOG4105EJQ L-serine dehydratase FOC85_RS06055 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC85_RS06065 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC85_RS06070 ENOG4105D9U N-acetyltransferase FOC85_RS06085 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC85_RS06090 ENOG4108QEG Membrane FOC85_RS06095 ENOG4105CDA abc transporter atp-binding protein FOC85_RS06100 ENOG4105E5Q amino acid AbC transporter FOC85_RS06105 ENOG4108HW3 (ABC) transporter FOC85_RS06115 ENOG4105G7B Protein of unknown function (DUF2992) FOC85_RS06120 ENOG4105E09 nadh pyrophosphatase FOC85_RS06130 ENOG4105C7S Dehydrogenase FOC85_RS06135 ENOG4105CPP Dehydrogenase, E1 component FOC85_RS06155 ENOG4107RDP Dehydrogenase FOC85_RS06165 ENOG4108JUB Transcriptional regulator FOC85_RS06175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_RS06190 ENOG4107QQR Sporulation FOC85_RS06195 ENOG4105S1Z Stage IV sporulation protein B FOC85_RS06200 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC85_RS06210 ENOG4105DX0 Hemolysin A FOC85_RS06220 ENOG4105CTB Polyprenyl synthetase FOC85_RS06245 ENOG4108ZSR alkaline shock protein FOC85_RS06250 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC85_RS06275 ENOG410644B Stage III sporulation protein af FOC85_RS06285 ENOG4105KQ4 Stage iii sporulation protein ad FOC85_RS06290 ENOG4108CQH stage III sporulation protein AC FOC85_RS06295 ENOG4105KR5 Stage iii sporulation protein FOC85_RS06300 ENOG4105CD2 stage iii sporulation protein aa FOC85_RS06325 ENOG4105DC7 peptidase M24 FOC85_RS06340 ENOG4105CBJ Metal-dependent enzyme FOC85_RS06350 ENOG4107YBY Hydrolase FOC85_RS06365 ENOG4105K7K Transcriptional regulator FOC85_RS06380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC85_RS06385 ENOG4105WZW rhodanese family FOC85_RS06405 ENOG41080TC multidrug resistance protein FOC85_RS06440 ENOG4105CJ1 ABC, transporter FOC85_RS06445 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS06475 ENOG4105C0D helicase FOC85_RS06595 ENOG4105C3R Methionine synthase FOC85_RS06605 ENOG4105C28 cystathionine FOC85_RS06610 ENOG4105C28 cystathionine FOC85_RS06630 ENOG4105C5X domain protein FOC85_RS06640 ENOG4105DKQ ROK family FOC85_RS06650 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC85_RS06665 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC85_RS06675 ENOG4105E2Z phosphate ABC transporter (Permease FOC85_RS06680 ENOG4105C8U phosphate abc transporter FOC85_RS06685 ENOG4105PWN phosphate abc transporter FOC85_RS06690 ENOG4107RF6 penicillin-binding protein FOC85_RS06700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_RS06725 ENOG4105N80 Ferric uptake regulator, Fur family FOC85_RS06735 ENOG4105FDK ABC transporter FOC85_RS06740 ENOG4108JYZ YitT family FOC85_RS06745 ENOG41069ZM Protein of unknown function (DUF2624) FOC85_RS06770 ENOG4105EGD dinuclear metal center protein, YbgI family FOC85_RS06785 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS06790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC85_RS06820 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC85_RS06825 ENOG4105KG3 cytidine deaminase FOC85_RS06830 ENOG4107YR5 Diacylglycerol kinase FOC85_RS06840 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC85_RS06845 ENOG4105C9A Phoh family FOC85_RS06855 ENOG41068P3 sporulation protein YqfC FOC85_RS06860 ENOG4105KTH gatB Yqey FOC85_RS06870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC85_RS06875 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC85_RS06905 ENOG4105CSA Coproporphyrinogen iii oxidase FOC85_RS06910 ENOG4105KVH Transcriptional regulator FOC85_RS06935 ENOG4105TQK DNA polymerase iii, delta' subunit FOC85_RS06945 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC85_RS06950 ENOG4108UK2 deaminase FOC85_RS06955 ENOG4105KQC Competence protein FOC85_RS06965 ENOG4105DXX methyltransferase FOC85_RS06975 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC85_RS06985 ENOG410812S Rna-binding protein FOC85_RS06995 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC85_RS07000 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC85_RS07015 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS07045 ENOG4108TVJ Nitroreductase FOC85_RS07060 ENOG4105G6Z alkaline phosphatase FOC85_RS07070 ENOG4108MUZ hydrolase FOC85_RS07105 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_RS07110 ENOG4105MIR Phenylalanine 4-monooxygenase FOC85_RS07120 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC85_RS07160 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC85_RS07165 ENOG4108V5C ABC transporter FOC85_RS07175 ENOG4105C0A alcohol dehydrogenase FOC85_RS07180 ENOG4105C28 cystathionine FOC85_RS07210 ENOG4107XRG penicillin-binding protein FOC85_RS07225 ENOG4105CFP Peptidase U32 FOC85_RS07230 ENOG4105XYU peptidase (U32 family) FOC85_RS07240 ENOG4105HHA aminodeoxychorismate lyase FOC85_RS07270 ENOG4105C02 permease FOC85_RS07285 ENOG41060CR FOC85_RS07290 ENOG4105C7H Helicase, RecD TraA family FOC85_RS07305 ENOG4105C3J Cysteine desulfurase FOC85_RS07315 ENOG4105D1H recombination factor protein RarA FOC85_RS07320 ENOG4108VCI transcription factor, rsfa family FOC85_RS07325 ENOG4105CUZ uba thif-type nad fad binding protein FOC85_RS07350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC85_RS07360 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC85_RS07365 ENOG41076HS cation diffusion facilitator family transporter FOC85_RS07370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC85_RS07380 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC85_RS07385 ENOG4108QG2 Membrane FOC85_RS07395 ENOG4105VIE preprotein translocase, subunit YajC FOC85_RS07410 ENOG41061AI Protein of unknown function (DUF2905) FOC85_RS07425 ENOG4108HUF Transporter FOC85_RS07435 ENOG4108IPJ Membrane FOC85_RS07440 ENOG41082BM Transcriptional regulator, arsr family FOC85_RS07465 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC85_RS07470 ENOG4108IYU L-aspartate oxidase FOC85_RS07485 ENOG4108RPX mosc domain containing protein FOC85_RS07490 ENOG4105CQC Prephenate dehydratase FOC85_RS07510 ENOG4105EWM Histidine kinase FOC85_RS07535 ENOG4105X36 (ribosomal) protein FOC85_RS07545 ENOG4105C03 ribonuclease FOC85_RS07560 ENOG4107QMS site-determining protein FOC85_RS07580 ENOG4105DFF Rod shape-determining protein mreb FOC85_RS07660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC85_RS07675 ENOG41068KH stage VI sporulation protein D FOC85_RS07685 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC85_RS07710 ENOG4105K56 Transcriptional regulator FOC85_RS07730 ENOG4108IUQ atp-dependent protease FOC85_RS07760 ENOG4108QCI YvbH-like oligomerisation region FOC85_RS07775 ENOG4105M59 Phosphodiesterase, mj0936 family FOC85_RS07790 ENOG4108XJQ germination protein FOC85_RS07800 ENOG4108PCX Major Facilitator FOC85_RS07810 ENOG4105KBX Transcriptional regulator, TetR family FOC85_RS07825 ENOG4105PFC Transcriptional regulator FOC85_RS07835 ENOG4105DZC cytosine deaminase FOC85_RS07840 ENOG41067S9 phage shock protein C, PspC FOC85_RS07845 ENOG4108JCI Transcriptional regulator FOC85_RS07855 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC85_RS07860 ENOG4108Z40 Transcriptional regulator FOC85_RS07865 ENOG4105RHA ABC transporter, permease FOC85_RS07870 ENOG4108IUX (ABC) transporter FOC85_RS07875 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC85_RS07880 ENOG4105ER2 Ompa motb domain protein FOC85_RS07885 ENOG4105E14 MotA TolQ exbB proton channel FOC85_RS07890 ENOG4108VXD carboxy-peptidase FOC85_RS07900 ENOG4105E33 succinate dehydrogenase FOC85_RS07910 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC85_RS07925 ENOG4105K63 Thioredoxin FOC85_RS07930 ENOG4105C10 Electron transfer flavoprotein FOC85_RS07935 ENOG4105BZJ Electron transfer flavoprotein FOC85_RS07940 ENOG41060WC Enoyl-CoA hydratase FOC85_RS07945 ENOG4107Z3H Transcriptional regulator, TetR family FOC85_RS07950 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_RS07960 ENOG4105J76 Periplasmic binding protein FOC85_RS07965 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC85_RS08005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS08020 ENOG4105DR4 Methyltransferase FOC85_RS08035 ENOG4105KFN sortase, SrtB family FOC85_RS08040 ENOG4105E0A ABC, transporter FOC85_RS08055 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC85_RS08060 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC85_RS08070 ENOG4105FE9 pseudouridine synthase FOC85_RS08080 ENOG4105DCG PHP domain protein FOC85_RS08130 ENOG4108RWN rrna methyltransferase FOC85_RS08175 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS08180 ENOG4105CW7 secretion protein, HlyD family FOC85_RS08185 ENOG4108JGH Tetr family transcriptional regulator FOC85_RS08190 ENOG4105CN9 Peptidase m42 family protein FOC85_RS08215 ENOG4105C22 threonyL-tRNA synthetase FOC85_RS08220 ENOG4108TDW sporulation protein YtxC FOC85_RS08245 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC85_RS08250 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC85_RS08265 ENOG4105C2M dna polymerase I FOC85_RS08270 ENOG4105BZU Histidine kinase FOC85_RS08275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS08295 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC85_RS08300 ENOG4105BZN citrate synthase FOC85_RS08310 ENOG4108REF Sporulation integral membrane protein ytvi FOC85_RS08315 ENOG4105FS0 cytoplasmic membrane protein FOC85_RS08340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS08345 ENOG4105C6K Malic enzyme FOC85_RS08350 ENOG4105C0B DNA polymerase III (alpha subunit) FOC85_RS08355 ENOG4105VV2 FOC85_RS08365 ENOG4105SFS phosphoesterase RecJ domain protein FOC85_RS08405 ENOG4105DC7 peptidase M24 FOC85_RS08450 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC85_RS08460 ENOG4105VZ8 Transcriptional regulator FOC85_RS08480 ENOG4107YZX Universal stress protein FOC85_RS08520 ENOG4108JYZ YitT family FOC85_RS08535 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC85_RS08545 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC85_RS08550 ENOG4105KBJ sporulation protein ytfj FOC85_RS08565 ENOG4105EFZ amidohydrolase FOC85_RS08575 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC85_RS08600 ENOG4106KR7 LysR family Transcriptional regulator FOC85_RS08610 ENOG4105U5Y Transcriptional regulator FOC85_RS08620 ENOG4105C28 cystathionine FOC85_RS08670 ENOG4105EMN RNA polymerase sigma factor FOC85_RS08685 ENOG4105F1V Acetoin utilization protein FOC85_RS08690 ENOG4105W87 Cbs domain FOC85_RS08695 ENOG4105DGU Histone deacetylase FOC85_RS08710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS08720 ENOG4107SNB ankyrin repeat protein YahD FOC85_RS08725 ENOG4105EP9 oxidoreductase FOC85_RS08755 ENOG4105ETE Transcriptional regulator (LacI family FOC85_RS08775 ENOG4105C88 aminopeptidase FOC85_RS08820 ENOG4108VDD TRNA binding domain protein FOC85_RS08850 ENOG4105C8F Beta-lactamase domain protein FOC85_RS08865 ENOG4108V15 phosphotransferase enzyme family FOC85_RS08870 ENOG4108IUM Glycogen debranching enzyme FOC85_RS08880 ENOG4107QSE Dipeptidase FOC85_RS08885 ENOG4105YW5 deoR family transcriptional regulator FOC85_RS08900 ENOG4105CBX hi0933 family FOC85_RS08935 ENOG4108VJ1 Transcriptional regulator (CarD family FOC85_RS08940 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC85_RS08960 ENOG4108ZAF Molybdopterin FOC85_RS08965 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC85_RS08970 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC85_RS08980 ENOG4105D06 uba thif-type nad fad binding protein FOC85_RS08985 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC85_RS09005 ENOG41085GJ domain protein FOC85_RS09015 ENOG4105DWV Homoserine O-trans-acetylase FOC85_RS09025 ENOG4108B31 Spore germination protein FOC85_RS09055 ENOG410605W Major Facilitator FOC85_RS09060 ENOG4107S91 Sodium hydrogen exchanger FOC85_RS09065 ENOG4105NCW Trka-c domain protein FOC85_RS09080 ENOG4105C19 ABC transporter FOC85_RS09100 ENOG4105N5T Radical SAM Protein FOC85_RS09110 ENOG4105CIG ABC transporter FOC85_RS09155 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC85_RS09160 ENOG4108Z0R Transferase FOC85_RS09165 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC85_RS09170 ENOG4105BZF Glycosyl transferase (Group 1 FOC85_RS09180 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC85_RS09245 ENOG4107XGZ Hydrolase FOC85_RS09250 ENOG4105E98 transcriptional regulator DeoR family FOC85_RS09260 ENOG4105BZU Histidine kinase FOC85_RS09265 ENOG4105BZU Histidine kinase FOC85_RS09270 ENOG4107S9D Alpha beta hydrolase FOC85_RS09275 ENOG4107T7U Sulfatase FOC85_RS09290 ENOG4105D2X ABC transporter substrate-binding protein FOC85_RS09300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC85_RS09315 ENOG4107XGZ Hydrolase FOC85_RS09360 ENOG4108V2W Carbonate dehydratase FOC85_RS09365 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC85_RS09370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC85_RS09415 ENOG41087YS Phage shock protein A FOC85_RS09475 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC85_RS09480 ENOG4105BZU Histidine kinase FOC85_RS09485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS09510 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC85_RS09515 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC85_RS09525 ENOG4105D7V transposase FOC85_RS09545 ENOG4107ZTW SNARE associated Golgi FOC85_RS09555 ENOG41063TF transcriptional regulator (AraC FOC85_RS09570 ENOG4105C19 ABC transporter FOC85_RS09575 ENOG41086D8 Transcriptional regulator FOC85_RS09615 ENOG4105C6Z Gluconate FOC85_RS09640 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC85_RS09660 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_RS09670 ENOG4108IPT Naphthoate synthase FOC85_RS09675 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC85_RS09685 ENOG4105E4F Isochorismate synthase FOC85_RS09690 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC85_RS09700 ENOG4105VEQ Cold shock protein FOC85_RS09745 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_RS09845 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC85_RS09880 ENOG4105KT7 mgtC SapB transporter FOC85_RS09885 ENOG4107PBV potassium channel FOC85_RS09900 ENOG4105WG9 Conserved Protein FOC85_RS09910 ENOG4105CHM Aminotransferase FOC85_RS09915 ENOG4108ZB6 transcriptional regulator AsnC family FOC85_RS09920 ENOG4105C5I Dehydrogenase FOC85_RS09925 ENOG4108MUZ hydrolase FOC85_RS09935 ENOG4105C87 Aminotransferase class I and II FOC85_RS09950 ENOG4105Y38 Kinase-associated protein B FOC85_RS09960 ENOG4107R3E Citrate transporter FOC85_RS09980 ENOG4105KA0 thioesterase Superfamily protein FOC85_RS09995 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC85_RS10015 ENOG41069ER domain protein FOC85_RS10030 ENOG4105CEP NADH dehydrogenase FOC85_RS10060 ENOG4105EWC Purine nucleoside phosphorylase FOC85_RS10070 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC85_RS10095 ENOG4108JJA ABC, transporter FOC85_RS10100 ENOG4105C4B ABC transporter, permease FOC85_RS10105 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC85_RS10130 ENOG41083MR nifu domain-containing protein FOC85_RS10145 ENOG4108W5N phosphatidylglycerophosphatase a FOC85_RS10160 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_RS10165 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC85_RS10170 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC85_RS10185 ENOG4105CBT Fructose-1,6-bisphosphatase FOC85_RS10200 ENOG4105MMD transcriptional regulator FOC85_RS10205 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC85_RS10210 ENOG4107TXC Transcriptional regulator FOC85_RS10215 ENOG41090T1 Membrane FOC85_RS10240 ENOG4105FAA peptidase M23 FOC85_RS10250 ENOG4105KZD Domain of unknown function (DUF1805) FOC85_RS10255 ENOG4107R8B 5'-nucleotidase FOC85_RS10270 ENOG4105DIW FeS assembly protein SUFB FOC85_RS10275 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC85_RS10280 ENOG4105C9B Cysteine desulfurase FOC85_RS10285 ENOG4105JRK feS assembly protein SufD FOC85_RS10290 ENOG4105C3K feS assembly ATPase SufC FOC85_RS10295 ENOG4105D01 (LipO)protein FOC85_RS10300 ENOG4105D01 (LipO)protein FOC85_RS10305 ENOG4108UMI ABC transporter, permease FOC85_RS10335 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC85_RS10380 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC85_RS10405 ENOG4108IMY Transcriptional regulator FOC85_RS10415 ENOG4108W8B Beta-lactamase domain protein FOC85_RS10425 ENOG4108IUW ABC transporter FOC85_RS10450 ENOG4105C1G acyl-Coa dehydrogenase FOC85_RS10455 ENOG4105CHU acetyl-coa acetyltransferase FOC85_RS10470 ENOG4105DZ1 carboxypeptidase FOC85_RS10490 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_RS10510 ENOG4108SUT Major Facilitator Superfamily FOC85_RS10515 ENOG4107R7I amino acid FOC85_RS10530 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC85_RS10540 ENOG4107AYK membrAne FOC85_RS10575 ENOG4107ZTW SNARE associated Golgi FOC85_RS10585 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC85_RS10590 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS10595 ENOG4105BZU Histidine kinase FOC85_RS10615 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_RS10620 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_RS10625 ENOG4105VG1 fes assembly suf system protein FOC85_RS10630 ENOG4105D4Y metalloprotease FOC85_RS10650 ENOG4107S91 Sodium hydrogen exchanger FOC85_RS10655 ENOG4105NCW Trka-c domain protein FOC85_RS10665 ENOG4108RMU ferritin dps family protein FOC85_RS10680 ENOG4108URH decarboxylase FOC85_RS10700 ENOG4105D9N nucleoside FOC85_RS10705 ENOG4105D9N nucleoside FOC85_RS10720 ENOG4108RYK Nad-dependent epimerase dehydratase FOC85_RS10735 ENOG4105CV8 reductase FOC85_RS10740 ENOG4105F27 Major Facilitator FOC85_RS10745 ENOG4105KVH Transcriptional regulator FOC85_RS10760 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC85_RS10785 ENOG4105WMR Protein CrcB homolog FOC85_RS10810 ENOG4105C5H ABC transporter FOC85_RS10815 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC85_RS10835 ENOG4108IPW abc transporter atp-binding protein FOC85_RS10840 ENOG4105CM4 permease protein FOC85_RS10855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS10870 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC85_RS10880 ENOG4105XZU Preprotein translocase, subunit SecG FOC85_RS10885 ENOG41067MG lrgb family FOC85_RS10935 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS10955 ENOG41090VF Stage v sporulation protein ac FOC85_RS10960 ENOG4105CZ3 stage V sporulation protein ad FOC85_RS10975 ENOG4105H67 Protein of unknown function (DUF421) FOC85_RS10985 ENOG4105KRI phosphocarrier protein (HPr FOC85_RS10995 ENOG4105CHW UPF0052 protein FOC85_RS11005 ENOG4108Z4K mutator MutT protein FOC85_RS11015 ENOG4105C3M thioredoxin reductase FOC85_RS11025 ENOG4108S4C acetyltransferase FOC85_RS11045 ENOG41086DT Membrane protein of unknown function FOC85_RS11095 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_RS11100 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC85_RS11115 ENOG4107TXC Transcriptional regulator FOC85_RS11140 ENOG4105HMI Membrane FOC85_RS11145 ENOG4105DUM transcriptional regulator, lysR family FOC85_RS11155 ENOG4108WS4 fmn reductase FOC85_RS11160 ENOG4105C5H ABC transporter FOC85_RS11170 ENOG4105BZ1 (ABC) transporter FOC85_RS11180 ENOG4105CN1 protease FOC85_RS11185 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC85_RS11190 ENOG4105CAK Cell division ATP-binding protein ftsE FOC85_RS11210 ENOG4105MS2 ribosomal subunit Interface protein FOC85_RS11215 ENOG4105VEQ Cold shock protein FOC85_RS11220 ENOG41081UC Inherit from COG: Competence protein FOC85_RS11235 ENOG4105KVH Transcriptional regulator FOC85_RS11245 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC85_RS11250 ENOG4108KGH TRANSCRIPTIONal FOC85_RS11255 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC85_RS11260 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC85_RS11265 ENOG4105ESV Glycosyl transferase, family 4 FOC85_RS11275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC85_RS11295 ENOG4105F8D glycoside hydrolase family 4 FOC85_RS11300 ENOG4105VCP PTS System FOC85_RS11305 ENOG4105CK1 PTS System FOC85_RS11315 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC85_RS11335 ENOG4105VCP PTS System FOC85_RS11345 ENOG4105VZJ PTS System FOC85_RS11360 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC85_RS11380 ENOG4105ECB domain protein FOC85_RS11385 ENOG4107RSM transcriptional regulator FOC85_RS11420 ENOG4105DAA L-lactate FOC85_RS11425 ENOG4105D7V transposase FOC85_RS11435 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC85_RS11445 ENOG4105E0M Sulfatase FOC85_RS11470 ENOG4107R8N Glycosyl transferase, family 2 FOC85_RS11475 ENOG4105C94 Transporter FOC85_RS11480 ENOG41069ER domain protein FOC85_RS11505 ENOG4105KBK Zinc finger, swim domain protein FOC85_RS11510 ENOG4105C0D helicase FOC85_RS11540 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS11555 ENOG4107RBB ABC transporter, permease FOC85_RS11560 ENOG4105C19 ABC transporter FOC85_RS11580 ENOG4105CXY transporter FOC85_RS11600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS11605 ENOG4105DG6 mannose-6-phosphate isomerase FOC85_RS11610 ENOG4105DM4 PTS System FOC85_RS11620 ENOG4105CMR udp-glucose 4-epimerase FOC85_RS11630 ENOG4108KGH TRANSCRIPTIONal FOC85_RS11635 ENOG4105DG6 mannose-6-phosphate isomerase FOC85_RS11640 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC85_RS11645 ENOG4105CPK Glycosyl transferase (Group 1 FOC85_RS11650 ENOG4108TJN glycosyl transferase group 1 FOC85_RS11655 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC85_RS11675 ENOG4105D3Q Sugar transferase FOC85_RS11680 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC85_RS11685 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC85_RS11690 ENOG4107YJ4 chain length determinant protein FOC85_RS11695 ENOG4105HTX biosynthesis protein FOC85_RS11700 ENOG4107YJ4 chain length determinant protein FOC85_RS11715 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC85_RS11725 ENOG4105FRN stage II sporulation protein FOC85_RS11740 ENOG4105DY9 regulatoR FOC85_RS11760 ENOG4106778 Protein of unknown function (DUF1146) FOC85_RS11765 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC85_RS11770 ENOG4105C8S subunit m FOC85_RS11775 ENOG4105D65 subunit l FOC85_RS11805 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC85_RS11820 ENOG4105BZU Histidine kinase FOC85_RS11870 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC85_RS11875 ENOG41062M3 atp synthase FOC85_RS11905 ENOG4108YZG isomerase FOC85_RS11920 ENOG4108VGI doxx family FOC85_RS11925 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC85_RS11940 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC85_RS11950 ENOG4108ZXQ stage ii sporulation protein r FOC85_RS11955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC85_RS11975 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC85_RS11980 ENOG4105CBT Fructose-1,6-bisphosphatase FOC85_RS12020 ENOG4105C1G acyl-Coa dehydrogenase FOC85_RS12025 ENOG4105C1G acyl-Coa dehydrogenase FOC85_RS12030 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC85_RS12040 ENOG4105DF6 Fe-S oxidoreductase FOC85_RS12055 ENOG4105BZU Histidine kinase FOC85_RS12080 ENOG4105BZU Histidine kinase FOC85_RS12085 ENOG4105KCT ABC transporter FOC85_RS12090 ENOG4108M15 ABC transporter FOC85_RS12095 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_RS12105 ENOG4105IIU Aminopeptidase FOC85_RS12125 ENOG4105EMN RNA polymerase sigma factor FOC85_RS12135 ENOG410684U Domain of unknown function (DUF1934) FOC85_RS12155 ENOG4105CYW agmatinase FOC85_RS12165 ENOG4105DXB Major Facilitator superfamily FOC85_RS12170 ENOG4107SWG transcriptional regulator MERR family FOC85_RS12175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC85_RS12180 ENOG4105BZ4 penicillin-binding protein FOC85_RS12185 ENOG4108XFG YwhD family FOC85_RS12190 ENOG4108Z4T Peptidase M50 FOC85_RS12195 ENOG41069HH 4-oxalocrotonate tautomerase FOC85_RS12200 ENOG4105DCI Phosphohydrolase FOC85_RS12205 ENOG4108MES Periplasmic binding protein FOC85_RS12210 ENOG4105E0A ABC, transporter FOC85_RS12215 ENOG4105EHG Permease protein FOC85_RS12220 ENOG4105DQ5 transport system permease protein FOC85_RS12230 ENOG4108VCI transcription factor, rsfa family FOC85_RS12245 ENOG4108IJ2 phosphate acetyltransferase FOC85_RS12260 ENOG4108VKI Cell wall hydrolase FOC85_RS12280 ENOG4107SVH Potassium channel protein FOC85_RS12290 ENOG410667J hydrolase FOC85_RS12295 ENOG4105VCH membrane FOC85_RS12305 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC85_RS12310 ENOG4105CJ1 ABC, transporter FOC85_RS12315 ENOG41090WU lipolytic protein G-D-S-L family FOC85_RS12330 ENOG4105D6E homoserine dehydrogenase FOC85_RS12350 ENOG4108Y4K DNA-binding transcriptional activator FOC85_RS12360 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_RS12365 ENOG4105BZU Histidine kinase FOC85_RS12370 ENOG4105DWF phosphomethylpyrimidine kinase FOC85_RS12375 ENOG4105BZU Histidine kinase FOC85_RS12380 ENOG4105VCD cytoplasmic protein FOC85_RS12385 ENOG4105D22 carbon starvation protein FOC85_RS12390 ENOG4105DY9 regulatoR FOC85_RS12395 ENOG41079KZ Major Facilitator Superfamily FOC85_RS12415 ENOG4105EN6 Membrane FOC85_RS12420 ENOG4106YBV Methyl-accepting chemotaxis FOC85_RS12430 ENOG4108S4H thioesterase Superfamily protein FOC85_RS12440 ENOG4105JEU Glycosyl transferase, family 2 FOC85_RS12445 ENOG4105C5H ABC transporter FOC85_RS12465 ENOG4105CKK Glycosyl transferase, family 2 FOC85_RS12470 ENOG41067SE Tetr family transcriptional regulator FOC85_RS12480 ENOG4105E0X reductase FOC85_RS12485 ENOG4106F5Q Membrane FOC85_RS12500 ENOG4105DY9 regulatoR FOC85_RS12505 ENOG4108HRK Histidine kinase FOC85_RS12510 ENOG4107RGD Major Facilitator superfamily FOC85_RS12525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_RS12535 ENOG4105IW1 AmiS UreI transporter FOC85_RS12545 ENOG4105CMR udp-glucose 4-epimerase FOC85_RS12550 ENOG4108UT2 hemolysin iii FOC85_RS12560 ENOG4105C1J atp-dependent rna helicase FOC85_RS12575 ENOG4105DPN Oligoendopeptidase f FOC85_RS12595 ENOG4105C0H protease FOC85_RS12600 ENOG4105Q2H domain protein FOC85_RS12615 ENOG4105BZU Histidine kinase FOC85_RS12620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS12650 ENOG4105CDU Replicative dna helicase FOC85_RS12660 ENOG4105BZR domain protein FOC85_RS12665 ENOG4108XMW Membrane FOC85_RS12675 ENOG4108UUM single-stranded DNA-binding protein FOC85_RS12685 ENOG4105C3G gtp-binding protein FOC85_RS12690 ENOG4105VDK protein, conserved in bacteria FOC85_RS12695 ENOG4105D8X mechanosensitive ion channel FOC85_RS12700 ENOG4108ZDA Sporulation protein YyaC FOC85_RS12705 ENOG4105FA0 parb-like partition protein FOC85_RS12710 ENOG4107QJE Chromosome Partitioning Protein FOC85_RS12740 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC85_RS12760 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC85_RS12765 ENOG410848D S4 domain protein YaaA FOC85_RS12780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC85_RS12815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC85_RS12850 ENOG4105ZMH deoxynucleoside kinase FOC85_RS12860 ENOG4105GTG Isochorismatase FOC85_RS12865 ENOG4108Z6B deaminase FOC85_RS12875 ENOG4105C6E dna polymerase iii FOC85_RS12895 ENOG41067KS pro-sigma K processing FOC85_RS12930 ENOG4105CXN decarboxylase FOC85_RS12940 ENOG4105FA2 dna polymerase iii FOC85_RS12945 ENOG4105MA4 psp1 domain protein FOC85_RS12955 ENOG41060K3 Methyltransferase FOC85_RS12965 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC85_RS12970 ENOG4105KRN Transcriptional regulator, abrb family FOC85_RS12980 ENOG4105F8V Hydrolase, tatD family FOC85_RS12985 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC85_RS12995 ENOG4105XFA sporulation peptidase YabG FOC85_RS13000 ENOG4105W42 Veg protein FOC85_RS13015 ENOG4105DFT pur operon repressor FOC85_RS13020 ENOG4105KME endoribonuclease L-psp FOC85_RS13050 ENOG4108JA2 transcriptioN-repair coupling factor FOC85_RS13055 ENOG4108M14 stage v sporulation protein t FOC85_RS13065 ENOG4108IY2 MazG family FOC85_RS13070 ENOG41082I2 s4 domain protein FOC85_RS13075 ENOG4105VYY sporulation protein yabp FOC85_RS13090 ENOG41060GV RNA binding s1 domain protein FOC85_RS13115 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC85_RS13120 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC85_RS13135 ENOG4105C6T cysteine synthase FOC85_RS13140 ENOG4105CRQ synthase (Component I) FOC85_RS13145 ENOG4105DDQ anthranilate synthase FOC85_RS13150 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC85_RS13155 ENOG4105EEI dihydropteroate synthase FOC85_RS13160 ENOG4105KRF dihydroneopterin aldolase FOC85_RS13165 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC85_RS13175 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC85_RS13265 ENOG4108Z0C Uvrb UvrC protein FOC85_RS13280 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC85_RS13290 ENOG4105CTP PilT protein domain protein FOC85_RS13310 ENOG4105D7W serine acetyltransferase FOC85_RS13325 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC85_RS13330 ENOG4105M0M Tetracycline resistance protein FOC85_RS13335 ENOG4105QIV RNA polymerase FOC85_RS13350 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC85_RS13375 ENOG4107Y49 methyltransferase FOC85_RS13390 ENOG4105XPM ribosomal protein FOC85_RS13520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC85_RS13530 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_RS13575 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC85_RS13605 ENOG4105D1F ATP-binding protein FOC85_RS13620 ENOG4108NMV polysaccharide deacetylase FOC85_RS13700 ENOG4105C8B TIGR00159 family FOC85_RS13705 ENOG4107U5W ybbr family FOC85_RS13740 ENOG4105CMG Carbohydrate kinase FOC85_RS13750 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC85_RS13755 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC85_RS13795 ENOG4108PSK reductase FOC85_RS13800 ENOG4108UMI ABC transporter, permease FOC85_RS13805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC85_RS13810 ENOG4105D01 (LipO)protein FOC85_RS13825 ENOG4105IQ5 FAD linked oxidase domain protein FOC85_RS13840 ENOG4105C2C drug resistance transporter, Bcr CflA FOC85_RS13855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_RS13860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_RS13865 ENOG4105C3U ABC transporter FOC85_RS13870 ENOG4108JQ7 (ABC) transporter FOC85_RS13895 ENOG4105U5Y Transcriptional regulator FOC85_RS13905 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC85_RS13910 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC85_RS13920 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS13925 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC85_RS13935 ENOG4105E0C molybdate abc transporter FOC85_RS13940 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC85_RS13945 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC85_RS13975 ENOG4105F6E Acyl-transferase FOC85_RS13995 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC85_RS14005 ENOG4108RE7 deoxyribonuclease FOC85_RS14015 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC85_RS14040 ENOG4105C5H ABC transporter FOC85_RS14055 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC85_RS14065 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_RS14070 ENOG4105C3U ABC transporter FOC85_RS14075 ENOG4108JQ7 (ABC) transporter FOC85_RS14080 ENOG410667J hydrolase FOC85_RS14110 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC85_RS14115 ENOG4105ERH Fumarylacetoacetate hydrolase FOC85_RS14125 ENOG4105CUB amino acid FOC85_RS14130 ENOG4108SC4 )-transporter FOC85_RS14135 ENOG4105CPF Cell wall formation (By similarity) FOC85_RS14140 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC85_RS14155 ENOG4107ZXI Rhomboid family FOC85_RS14165 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC85_RS14170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC85_RS14180 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC85_RS14280 ENOG4105K8N protein family UPF0079, ATPase FOC85_RS14285 ENOG41072GX Peptidase M22 Glycoprotease FOC85_RS14290 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC85_RS14300 ENOG4105C5H ABC transporter FOC85_RS14315 ENOG4108TYN CAAX amino terminal protease family protein FOC85_RS14330 ENOG4107EV6 Inherit from COG: YD repeat protein FOC85_RS14350 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC85_RS14390 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_RS14400 ENOG4105BZU Histidine kinase FOC85_RS14425 ENOG4107ZXU DSBA oxidoreductase FOC85_RS14500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS14520 ENOG4105SX7 Transporter FOC85_RS14545 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC85_RS14550 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC85_RS14555 ENOG4105C83 adenylosuccinate lyase FOC85_RS14565 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC85_RS14590 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC85_RS14600 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC85_RS14625 ENOG4105C4R Atp-dependent dna helicase FOC85_RS14655 ENOG4108W2Y isochorismatase FOC85_RS14660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC85_RS14665 ENOG4108UMI ABC transporter, permease FOC85_RS14670 ENOG4105D01 (LipO)protein FOC85_RS14700 ENOG410834F Transcriptional regulator FOC85_RS14705 ENOG4107I77 yiaA/B two helix domain FOC85_RS14725 ENOG4105CBD Diacylglycerol kinase FOC85_RS14730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC85_RS14735 ENOG4108JPW Aminotransferase FOC85_RS14745 ENOG4105C26 Dehydrogenase FOC85_RS14750 ENOG4105KPY Small multidrug resistance protein FOC85_RS14770 ENOG4105D9N nucleoside FOC85_RS14775 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC85_RS14785 ENOG4105BZU Histidine kinase FOC85_RS14790 ENOG4108W15 Protein of unknown function (DUF1456) FOC85_RS14805 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_RS14815 ENOG4105DFD Na H antiporter FOC85_RS14835 ENOG4105D3R alkyl hydroperoxide reductase FOC85_RS14855 ENOG4105EHG Permease protein FOC85_RS14860 ENOG4105DQ5 transport system permease protein FOC85_RS14865 ENOG4108V5C ABC transporter FOC85_RS14885 ENOG4106UIA FOC85_RS14890 ENOG4106UIA FOC85_RS14910 ENOG4105BZU Histidine kinase FOC85_RS14930 ENOG410756H nucleotidyltransferase FOC85_RS14935 ENOG4105D2S major facilitator superfamily FOC85_RS14955 ENOG4105EAB amino acid AbC transporter FOC85_RS14965 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_RS14980 ENOG4105DBV ornithine carbamoyltransferase FOC85_RS14990 ENOG4105C5B carbamate kinase FOC85_RS15015 ENOG4105CI1 PTS System FOC85_RS15045 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC85_RS15060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC85_RS15105 ENOG41062JF Transcriptional regulator FOC85_RS15125 ENOG4105DEU major facilitator superfamily FOC85_RS15155 ENOG4108N0M stress protein FOC85_RS15160 ENOG4106FN3 tellurium resistance protein FOC85_RS15165 ENOG4106FN3 tellurium resistance protein FOC85_RS15170 ENOG4107TS3 membrane protein, TerC FOC85_RS15175 ENOG4108TTB tellurium resistance protein FOC85_RS15195 ENOG4105KJF protein tyrosine phosphatase FOC85_RS15205 ENOG4107U9T Pfam:Ribonuclease_BN FOC85_RS15210 ENOG4105C59 p-type ATPase FOC85_RS15215 ENOG4108IPJ Membrane FOC85_RS15235 ENOG4107ZTW SNARE associated Golgi FOC85_RS15250 ENOG410606W general stress protein FOC85_RS15255 ENOG4105UPD Calcium Proton FOC85_RS15305 ENOG4108JUB Transcriptional regulator FOC85_RS15315 ENOG4108IQI permease FOC85_RS15355 ENOG4108A04 Beta-lactamase FOC85_RS15370 ENOG4105CKK Glycosyl transferase, family 2 FOC85_RS15375 ENOG4107QQG Dehydrogenase FOC85_RS15380 ENOG4105C3I Nad-dependent epimerase dehydratase FOC85_RS15400 ENOG4105F1A Pyruvate formate-lyase FOC85_RS15420 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC85_RS15425 ENOG4105ECP epimerase FOC85_RS15455 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC85_RS15460 ENOG4105CEN a g-specific adenine glycosylase FOC85_RS15465 ENOG4106BXE FOC85_RS15485 ENOG4105BZ1 (ABC) transporter FOC85_RS15490 ENOG4107NBY Membrane FOC85_RS15495 ENOG4105CBC glutamate synthase FOC85_RS15505 ENOG4108IUW ABC transporter FOC85_RS15525 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC85_RS15530 ENOG4105G5W regulator Fur family FOC85_RS15665 ENOG4105BZ1 (ABC) transporter FOC85_RS15680 ENOG4108JQC penicillin-binding protein 1A FOC85_RS15685 ENOG4107ZQN disulfide bond FOC85_RS15700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC85_RS15710 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC85_RS15720 ENOG4105CYN Serine protein kinase FOC85_RS15740 ENOG4105C94 Transporter FOC85_RS15755 ENOG4105DZ6 Band 7 protein FOC85_RS15765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC85_RS15770 ENOG4108V9W transcriptional regulatory protein FOC85_RS15775 ENOG4105D4T Citrate transporter FOC85_RS15795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC85_RS15800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_RS15805 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC85_RS15810 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC85_RS15815 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC85_RS15820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC85_RS15825 ENOG4108STX response regulator FOC85_RS15830 ENOG4105US7 Histidine kinase FOC85_RS15855 ENOG4108MRH transcriptional regulatory protein FOC85_RS15865 ENOG4105C6K Malic enzyme FOC85_RS15875 ENOG4108UZ3 Transporter FOC85_RS15880 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS15890 ENOG4105BZU Histidine kinase FOC85_RS15895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS15900 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC85_RS15905 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC85_RS15910 ENOG4108JB9 formate dehydrogenase FOC85_RS15930 ENOG4105CUB amino acid FOC85_RS15940 ENOG4105C59 p-type ATPase FOC85_RS15945 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC85_RS15980 ENOG41073R8 VanW family FOC85_RS15985 ENOG4108KGH TRANSCRIPTIONal FOC85_RS15990 ENOG4105D9N nucleoside FOC85_RS15995 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC85_RS16000 ENOG4105C37 (CBS) domain FOC85_RS16005 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_RS16010 ENOG4105DAA L-lactate FOC85_RS16025 ENOG4105DUX Transporter FOC85_RS16030 ENOG4108MES Periplasmic binding protein FOC85_RS16035 ENOG4105DQ5 transport system permease protein FOC85_RS16040 ENOG4108IHU transport system permease protein FOC85_RS16045 ENOG4105E0A ABC, transporter FOC85_RS16050 ENOG4105DMQ Methyltransferase FOC85_RS16060 ENOG4105EXW epimerase dehydratase FOC85_RS16070 ENOG4107T89 von Willebrand factor, type A FOC85_RS16075 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC85_RS16080 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_RS16090 ENOG4105BZU Histidine kinase FOC85_RS16095 ENOG4105D5Q Arginine ornithine antiporter FOC85_RS16100 ENOG4107414 GntR family transcriptional regulator FOC85_RS16105 ENOG4105C5Y PTS System FOC85_RS16110 ENOG4105CG3 alpha amylase, catalytic region FOC85_RS16125 ENOG4105E1K spore germination protein FOC85_RS16130 ENOG4108XG2 Histidine kinase FOC85_RS16135 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_RS16140 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC85_RS16155 ENOG4105CRN Aminoglycoside phosphotransferase FOC85_RS16160 ENOG4105BZG amino acid carrier protein FOC85_RS16165 ENOG4105CDA abc transporter atp-binding protein FOC85_RS16170 ENOG4105CT1 (ABC) transporter FOC85_RS16175 ENOG4105EAD ABC transporter FOC85_RS16180 ENOG4105DRP amino acid AbC transporter FOC85_RS16185 ENOG4108IQI permease FOC85_RS16210 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC85_RS16215 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC85_RS16220 ENOG4105BZU Histidine kinase FOC85_RS16225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS16235 ENOG4105CHH sulfate transporter FOC85_RS16240 ENOG41068KF Universal stress protein FOC85_RS16250 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC85_RS16260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_RS16265 ENOG4108JQ7 (ABC) transporter FOC85_RS16275 ENOG4105CXY transporter FOC85_RS16280 ENOG41067TZ transcriptional regulator, MarR family FOC85_RS16285 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS16290 ENOG4105ETE Transcriptional regulator (LacI family FOC85_RS16295 ENOG4108RVA ribokinase FOC85_RS16310 ENOG4105CNN ABC, transporter FOC85_RS16315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC85_RS16380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC85_RS16385 ENOG41069ER domain protein FOC85_RS16390 ENOG4105VZ8 Transcriptional regulator FOC85_RS16395 ENOG4107D63 FOC85_RS16405 ENOG4105DUX Transporter FOC85_RS16425 ENOG4105C85 amino acid FOC85_RS16430 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_RS16445 ENOG4105MA6 gCN5-related N-acetyltransferase FOC85_RS16470 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC85_RS16475 ENOG4105E2S oxidase) subunit II FOC85_RS16490 ENOG4106CAD Protein of unknown function (DUF3311) FOC85_RS16495 ENOG4105E1V na solute symporter FOC85_RS16510 ENOG4108NHD germination protein FOC85_RS16515 ENOG4105CE1 Ferrous iron transport protein b FOC85_RS16520 ENOG4105CE1 Ferrous iron transport protein b FOC85_RS16525 ENOG4105CE1 Ferrous iron transport protein b FOC85_RS16530 ENOG4105CVA phosphate FOC85_RS16535 ENOG4105C8U phosphate abc transporter FOC85_RS16540 ENOG4105E2Z phosphate ABC transporter (Permease FOC85_RS16670 ENOG41080XQ Signal transduction protein with cbs domains FOC85_RS16690 ENOG4105ETU transcriptional activator (TenA FOC85_RS16700 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC85_RS16710 ENOG4108VEU Thiamine monophosphate synthase FOC85_RS16715 ENOG41080HI glycine oxidase FOC85_RS16730 ENOG4105D06 uba thif-type nad fad binding protein FOC85_RS16735 ENOG4105DWF phosphomethylpyrimidine kinase FOC85_RS16785 ENOG4108INS Transcriptional regulator FOC85_RS16810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC85_RS16820 ENOG4105C7N Xanthine uracil vitamin C permease FOC85_RS16830 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC85_RS16850 ENOG4105C5Y PTS System FOC85_RS16885 ENOG4108B31 Spore germination protein FOC85_RS16905 ENOG4107Y03 Nitroreductase FOC85_RS16910 ENOG4105ED1 spovr family FOC85_RS16915 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC85_RS16920 ENOG4105XTG Pfam:DUF156 FOC85_RS16925 ENOG4105VFE sira family FOC85_RS16930 ENOG4107TPS domain protein FOC85_RS16935 ENOG4105VFE sira family FOC85_RS16940 ENOG41085GJ domain protein FOC85_RS16950 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC85_RS16955 ENOG41087NI Sulfite exporter TauE/SafE FOC85_RS16965 ENOG4108KGH TRANSCRIPTIONal FOC85_RS16990 ENOG4105EMD TRANSCRIPTIONal FOC85_RS16995 ENOG4105VCP PTS System FOC85_RS17000 ENOG4105VZJ PTS System FOC85_RS17020 ENOG41069ER domain protein FOC85_RS17025 ENOG4107RBB ABC transporter, permease FOC85_RS17030 ENOG4105C19 ABC transporter FOC85_RS17065 ENOG4105WEF catalase FOC85_RS17100 ENOG4107T5V SNARE associated Golgi FOC85_RS17135 ENOG4105CUB amino acid FOC85_RS17140 ENOG4107RWR Sodium hydrogen exchanger FOC85_RS17150 ENOG4106KNT transcriptional regulator FOC85_RS17195 ENOG4108YXU transcriptional regulator AsnC family FOC85_RS17210 ENOG4105KPY Small multidrug resistance protein FOC85_RS17225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC85_RS17230 ENOG4105E5W Transporter FOC85_RS17240 ENOG4107RKG DJ-1/PfpI family FOC85_RS17245 ENOG4105CH6 catalase FOC85_RS17255 ENOG4105D5Q Arginine ornithine antiporter FOC85_RS17260 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC85_RS17270 ENOG4105C26 Dehydrogenase FOC85_RS17275 ENOG4105BZ1 (ABC) transporter FOC85_RS17280 ENOG4105BZ1 (ABC) transporter FOC85_RS17290 ENOG4105DRP amino acid AbC transporter FOC85_RS17295 ENOG4105CDA abc transporter atp-binding protein FOC85_RS17310 ENOG410839P FOC85_RS17345 ENOG4107FQX Alpha-acetolactate decarboxylase FOC85_RS17360 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC85_RS17365 ENOG4105D4P Coproporphyrinogen iii oxidase FOC85_RS17380 ENOG4105CHH sulfate transporter FOC85_RS17420 ENOG4106AKK s-layer domain-containing protein FOC85_RS17425 ENOG4106AKK s-layer domain-containing protein FOC85_RS17435 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC85_RS17445 ENOG4105CGU Enoyl-CoA hydratase FOC85_RS17465 ENOG4105DER m42 family FOC85_RS17485 ENOG4105CTU Proline racemase FOC85_RS17510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_RS17520 ENOG4108JQ7 (ABC) transporter FOC85_RS17565 ENOG4105CSH Transporter FOC85_RS17575 ENOG4108MRH transcriptional regulatory protein FOC85_RS17635 ENOG4105CDU Replicative dna helicase FOC85_RS17655 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS17715 ENOG4107P5I polyketide synthase FOC85_RS17720 ENOG4108IG5 Transcriptional regulator FOC85_RS17735 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC85_RS17765 ENOG4105CMT Dihydroxyacetone kinase FOC85_RS17775 ENOG4105CMT Dihydroxyacetone kinase FOC85_RS17780 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC85_RS17785 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC85_RS17800 ENOG410780I phosphoprotein phosphatase activity FOC85_RS17810 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC85_RS17875 ENOG4105WN5 stage II sporulation protein FOC85_RS17885 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC85_RS17895 ENOG4108MJI response regulator FOC85_RS17900 ENOG4105BZU Histidine kinase FOC85_RS17905 ENOG4105BZU Histidine kinase FOC85_RS17945 ENOG4105ENE Histidine kinase FOC85_RS17950 ENOG4108VB1 regulatoR FOC85_RS17980 ENOG4107VRP DNA repair exonuclease FOC85_RS17985 ENOG4106D4I domain protein FOC85_RS18035 ENOG4108MUZ hydrolase FOC85_RS18055 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC85_RS18070 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC85_RS18090 ENOG4105EMN RNA polymerase sigma factor FOC85_RS18115 ENOG4105C57 major facilitator superfamily FOC85_RS18120 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS18130 ENOG4105EEM helicase FOC85_RS18135 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_RS18160 ENOG4105K59 histidine triad (HIT) protein FOC85_RS18195 ENOG410905X membrane-flanked domain protein FOC85_RS18200 ENOG4105CKV Membrane FOC85_RS18220 ENOG41060BG Tetr family transcriptional regulator FOC85_RS18240 ENOG410905X membrane-flanked domain protein FOC85_RS18245 ENOG4105CKV Membrane FOC85_RS18250 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC85_RS18255 ENOG4105BZ4 penicillin-binding protein FOC85_RS18270 ENOG4105C1Q protoporphyrinogen oxidase FOC85_RS18300 ENOG4105NA0 Transcriptional regulator FOC85_RS18315 ENOG4105ECB domain protein FOC85_RS18320 ENOG4105ECB domain protein FOC85_RS18350 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC85_RS18360 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC85_RS18370 ENOG4106AXD FOC85_RS18375 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC85_RS18380 ENOG4105DF9 Lipoate-protein, ligase FOC85_RS18390 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_RS18450 ENOG4105ST3 Transcriptional regulator FOC85_RS18455 ENOG4105ENX hydrolase FOC85_RS18460 ENOG4107RN3 metallophosphoesterase FOC85_RS18470 ENOG4107TVP HD domain protein FOC85_RS18480 ENOG4108AEY RNA polymerase sigma factor FOC85_RS18485 ENOG41086D8 Transcriptional regulator FOC85_RS18495 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS18515 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC85_RS18540 ENOG4107QP3 malate synthase g FOC85_RS18570 ENOG4105XVF Competence transcription factor FOC85_RS18635 ENOG4105ERH Fumarylacetoacetate hydrolase FOC85_RS18660 ENOG4105CAQ asparagine synthetase FOC85_RS18665 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC85_RS18670 ENOG4105CH6 catalase FOC85_RS18675 ENOG4105BZU Histidine kinase FOC85_RS18695 ENOG4105QNR S1 RNA binding domain protein FOC85_RS18705 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_RS18715 ENOG4107AYK membrAne FOC85_RS18720 ENOG41073B9 FOC85_RS18730 ENOG4108KP7 hydrolase FOC85_RS18740 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC85_RS18765 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_RS18770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC85_RS18785 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC85_RS18800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC85_RS18805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC85_RS18815 ENOG4108JQ7 (ABC) transporter FOC85_RS18820 ENOG4105UQX Mate efflux family protein FOC85_RS18840 ENOG4108ZCF integral membrane protein FOC85_RS18850 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_RS18860 ENOG4105DPN Oligoendopeptidase f FOC85_RS18875 ENOG4108Z18 K06886 hemoglobin FOC85_RS18880 ENOG4105MIX Adenylate cyclase FOC85_RS18900 ENOG4105EMS pseudouridine synthase FOC85_RS18920 ENOG4105K64 Glycosyl transferase, family 2 FOC85_RS18940 ENOG4107TVC Glycosyl transferase, family 2 FOC85_RS18960 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC85_RS18965 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC85_RS18975 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC85_RS19050 ENOG4105CK7 Sodium proline symporter FOC85_RS19060 ENOG4105DDQ anthranilate synthase FOC85_RS19155 ENOG4105C7S Dehydrogenase FOC85_RS19165 ENOG4105VZ8 Transcriptional regulator FOC85_RS19225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_RS19240 ENOG4108IUX (ABC) transporter FOC85_RS19245 ENOG4105RHA ABC transporter, permease FOC85_RS19290 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_RS19305 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC85_RS19315 ENOG4105DZ1 carboxypeptidase FOC85_RS19320 ENOG4105VFR signal peptidase FOC85_RS19355 ENOG4105C26 Dehydrogenase FOC85_RS19365 ENOG4105F38 ABC transporter, permease FOC85_RS19370 ENOG4105D38 putrescine abc transporter FOC85_RS19375 ENOG4107RUE extracellular solute-binding protein family 1 FOC85_RS19385 ENOG4105EYF MMPL domain protein FOC85_RS19395 ENOG4108YBP pseudouridine synthase FOC85_RS19405 ENOG4105K4I Scp-like extracellular FOC85_RS19410 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC85_RS19415 ENOG4105CQB FAD linked oxidase domain protein FOC85_RS19430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS19435 ENOG4105BZU Histidine kinase FOC85_RS19440 ENOG4105JXH GntR family transcriptional regulator FOC85_RS19460 ENOG4106A3R peptidase FOC85_RS19470 ENOG4108QTI )-transporter FOC85_RS19475 ENOG4107TS3 membrane protein, TerC FOC85_RS19480 ENOG4105CZN Potassium uptake protein FOC85_RS19485 ENOG410681C small acid-soluble spore protein FOC85_RS19490 ENOG4108Z7G MaoC domain protein dehydratase FOC85_RS19510 ENOG4105CHR reductase FOC85_RS19520 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC85_RS19540 ENOG4105C4Y ABC transporter FOC85_RS19545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_RS19550 ENOG4107RCV ABC transporter, permease FOC85_RS19570 ENOG4105E98 transcriptional regulator DeoR family FOC85_RS19580 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC85_RS19590 ENOG4105PXI polysaccharide deacetylase FOC85_RS19600 ENOG4105BZU Histidine kinase FOC85_RS19605 ENOG41090MY MarR family Transcriptional regulator FOC85_RS19615 ENOG4106DF1 FOC85_RS19620 ENOG4105BZU Histidine kinase FOC85_RS19630 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC85_RS19635 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC85_RS19675 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC85_RS19680 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC85_RS19685 ENOG41079K6 HNH endonuclease FOC85_RS19695 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC85_RS19700 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS19705 ENOG4105CZV ABC transporter FOC85_RS19715 ENOG4105CJ1 ABC, transporter FOC85_RS19755 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC85_RS19760 ENOG4105EA8 2-Nitropropane dioxygenase FOC85_RS19765 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC85_RS19775 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC85_RS19800 ENOG4105NQC Flavodoxin FOC85_RS19835 ENOG4107QMU Mate efflux family protein FOC85_RS19840 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC85_RS19870 ENOG4105CZN Potassium uptake protein FOC85_RS19875 ENOG41063Y9 FOC85_RS19880 ENOG4105KBJ sporulation protein ytfj FOC85_RS19905 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC85_RS19910 ENOG4105C7K acetolactate synthase FOC85_RS19915 ENOG4108ZP8 Acetolactate synthase small subunit FOC85_RS19990 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC85_RS20000 ENOG4105C5I Dehydrogenase FOC85_RS20005 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC85_RS20010 ENOG4105E0M Sulfatase FOC85_RS20020 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC85_RS20040 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC85_RS20045 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC85_RS20055 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC85_RS20060 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC85_RS20065 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC85_RS20070 ENOG4105C8J )-transporter FOC85_RS20090 ENOG4105DFD Na H antiporter FOC85_RS20110 ENOG4105ENE Histidine kinase FOC85_RS20115 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_RS20135 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC85_RS20180 ENOG4105CJ3 phosphate transporter FOC85_RS20185 ENOG4107GRR phosphate transport regulator FOC85_RS20190 ENOG4105BZ4 penicillin-binding protein FOC85_RS20205 ENOG4105BZU Histidine kinase FOC85_RS20210 ENOG4105I3N Conserved Protein FOC85_RS20225 ENOG4105BZU Histidine kinase FOC85_RS20255 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC85_RS20260 ENOG4105DZ1 carboxypeptidase FOC85_RS20265 ENOG4108JIC nucleoside recognition domain protein FOC85_RS20275 ENOG4105FE9 pseudouridine synthase FOC85_RS20285 ENOG4107TWT Cytochrome c biogenesis protein FOC85_RS20290 ENOG4105CRE cytochrome C FOC85_RS20295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS20300 ENOG4105BZU Histidine kinase FOC85_RS20305 ENOG4108WBT adenosyltransferase FOC85_RS20310 ENOG41063SB peptidase FOC85_RS20320 ENOG4108SAX Membrane FOC85_RS20335 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC85_RS20340 ENOG4105I7S Abortive infection protein FOC85_RS20350 ENOG4107RGJ metallophosphoesterase FOC85_RS20355 ENOG4107X2D transcriptional regulator, merr family FOC85_RS20360 ENOG4108S6Z Negative regulator of genetic competence FOC85_RS20385 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC85_RS20390 ENOG4105HDK L-asparaginase FOC85_RS20425 ENOG4105S2F FOC85_RS20430 ENOG41065D1 FOC85_RS20460 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC85_RS20475 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC85_RS20485 ENOG4105EAH synthase FOC85_RS20505 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC85_RS20510 ENOG41068YB TPR repeat-containing protein FOC85_RS20525 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC85_RS20530 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC85_RS20535 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC85_RS20565 ENOG4108JYZ YitT family FOC85_RS20570 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC85_RS20585 ENOG4105FJR Lmbe family FOC85_RS20590 ENOG4105CPK Glycosyl transferase (Group 1 FOC85_RS20625 ENOG4105DVT helicase FOC85_RS20630 ENOG4105YAC FOC85_RS20650 ENOG4105CSM endonuclease III FOC85_RS20660 ENOG4105BZ4 penicillin-binding protein FOC85_RS20720 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC85_RS20730 ENOG4105DVT helicase FOC85_RS20735 ENOG4105CTD carboxy-peptidase FOC85_RS20750 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC85_RS20760 ENOG4105C2W permease FOC85_RS20765 ENOG4105DHF Membrane FOC85_RS20770 ENOG410890F Dynamin family FOC85_RS20780 ENOG4108W0I acetyltransferase FOC85_RS20790 ENOG4105KHC sulfurtransferase FOC85_RS20815 ENOG4106032 Glutathionylspermidine synthase FOC85_RS20845 ENOG4108SZE gCN5-related N-acetyltransferase FOC85_RS20865 ENOG41081VK Ribonuclease FOC85_RS20930 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_RS20940 ENOG4107RWR Sodium hydrogen exchanger FOC85_RS20945 ENOG4105CN5 Metallo-Beta-Lactamase FOC85_RS20950 ENOG4108Z5V transcriptional regulator, merr family FOC85_RS20960 ENOG4105H67 Protein of unknown function (DUF421) FOC85_RS20965 ENOG41080C8 DUF218 domain FOC85_RS21020 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC85_RS21030 ENOG4107R0U MotA TolQ exbB proton channel FOC85_RS21035 ENOG4105ER2 Ompa motb domain protein FOC85_RS21040 ENOG4107YTP response regulator receiver protein FOC85_RS21045 ENOG4105CBS Chea signal transduction histidine kinase FOC85_RS21050 ENOG4105DD5 Flagellar motor switch protein FOC85_RS21065 ENOG4105BZU Histidine kinase FOC85_RS21085 ENOG4105E1Q flagellar hook-associated protein FOC85_RS21090 ENOG4105DTJ flagellar hook-associated protein FOC85_RS21095 ENOG4107TPX flagellar hook-associated FOC85_RS21110 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC85_RS21115 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC85_RS21125 ENOG4107U2N Flagellar M-ring protein FOC85_RS21130 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC85_RS21160 ENOG4105BZE flagellar hook protein, FlgE FOC85_RS21175 ENOG4107R88 Chemotaxis protein (CheV) FOC85_RS21185 ENOG4105I03 Flagellin FOC85_RS21190 ENOG4105I03 Flagellin FOC85_RS21195 ENOG4105E4C Lytic transglycosylase catalytic FOC85_RS21205 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC85_RS21210 ENOG4105DD5 Flagellar motor switch protein FOC85_RS21220 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC85_RS21225 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC85_RS21235 ENOG4105D00 flagellar biosynthetic protein flhB FOC85_RS21240 ENOG4105D7B Flagellar biosynthesis protein flha FOC85_RS21245 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC85_RS21250 ENOG4105KTQ flagellar basal-body rod protein FOC85_RS21255 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC85_RS21280 ENOG41062JF Transcriptional regulator FOC85_RS21310 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC85_RS21340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC85_RS21350 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC85_RS21355 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC85_RS21395 ENOG4105CVJ phosphoglycerate mutase FOC85_RS21415 ENOG4105K56 Transcriptional regulator FOC85_RS21425 ENOG4105CAQ asparagine synthetase FOC85_RS21445 ENOG4105PGM cation diffusion facilitator family transporter FOC85_RS21455 ENOG4105DRR Transcriptional regulator, GntR family FOC85_RS21460 ENOG4108UZ3 Transporter FOC85_RS21465 ENOG4105CKI cobalamin synthesis protein FOC85_RS21470 ENOG4108PJD permease FOC85_RS21485 ENOG4105DFD Na H antiporter FOC85_RS21490 ENOG4105C9Q fumarate hydratase class II FOC85_RS21510 ENOG4107QJQ Mate efflux family protein FOC85_RS21515 ENOG4105EC3 peptidase S51, dipeptidase E FOC85_RS21535 ENOG4107QIV Cytochrome c biogenesis protein FOC85_RS21565 ENOG4106BRA Membrane FOC85_RS21600 ENOG4105CJ1 ABC, transporter FOC85_RS21620 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC85_RS21630 ENOG4108IJ0 Aspartate ammonia-lyase FOC85_RS21635 ENOG4105C6K Malic enzyme FOC85_RS21670 ENOG41067QW Transcriptional regulator FOC85_RS21690 ENOG4105FVX FOC85_RS21725 ENOG4105CSR polyphosphate kinase 2 FOC85_RS21730 ENOG4105DXI Major Facilitator superfamily FOC85_RS21745 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC85_RS21755 ENOG4105EU0 Major facilitator Superfamily FOC85_RS21760 ENOG4105C6T cysteine synthase FOC85_RS21780 ENOG4105C8J )-transporter FOC85_RS21790 ENOG4105X5K response regulator receiver protein FOC85_RS21795 ENOG4105H67 Protein of unknown function (DUF421) FOC85_RS21815 ENOG4106KE4 Dehydrogenase FOC85_RS21830 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC85_RS21835 ENOG4105CHR reductase FOC85_RS21840 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC85_RS21845 ENOG4105C7K acetolactate synthase FOC85_RS21855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC85_RS21865 ENOG4105C7B Threonine dehydratase FOC85_RS21890 ENOG4105C6X Major Facilitator FOC85_RS21895 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC85_RS21915 ENOG4105DY9 regulatoR FOC85_RS21920 ENOG4105CYC Transferase FOC85_RS21980 ENOG41068WN FOC85_RS21985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS22005 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC85_RS22020 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC85_RS22025 ENOG4105C0X amino acid FOC85_RS22070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS22080 ENOG4107RHR regulatoR FOC85_RS22090 ENOG4105D9N nucleoside FOC85_RS22095 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC85_RS22125 ENOG4107RAQ aminopeptidase FOC85_RS22130 ENOG4107R16 Multicopper oxidase FOC85_RS22175 ENOG4108T5E Copper resistance protein FOC85_RS22180 ENOG4105KTB nuclear export factor GLE1 FOC85_RS22185 ENOG4107RT3 EamA-like transporter family FOC85_RS22190 ENOG4105GZI Transcriptional regulator FOC85_RS22195 ENOG4108Z40 Transcriptional regulator FOC85_RS22200 ENOG4107ZXU DSBA oxidoreductase FOC85_RS22205 ENOG4108TVJ Nitroreductase FOC85_RS22210 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC85_RS22215 ENOG4106F5Q Membrane FOC85_RS22230 ENOG4105CKI cobalamin synthesis protein FOC85_RS22250 ENOG4108Z7G MaoC domain protein dehydratase FOC85_RS22255 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC85_RS22265 ENOG4105C0Z ABC transporter FOC85_RS22270 ENOG4108IV0 ABC, transporter FOC85_RS22275 ENOG4105C32 Amino acid ABC transporter (Permease) FOC85_RS22285 ENOG4105EGI Transcriptional regulator FOC85_RS22295 ENOG4105MDS 4-oxalocrotonate tautomerase FOC85_RS22315 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC85_RS22320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC85_RS22325 ENOG4108JJ9 ABC, transporter FOC85_RS22330 ENOG4108JJ8 (ABC) transporter FOC85_RS22375 ENOG4105BZ1 (ABC) transporter FOC85_RS22380 ENOG4105EFI regulatoR FOC85_RS22385 ENOG4105EB3 Histidine kinase FOC85_RS22405 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC85_RS22430 ENOG4105D6E homoserine dehydrogenase FOC85_RS22455 ENOG4108KGH TRANSCRIPTIONal FOC85_RS22465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC85_RS22470 ENOG4105BZU Histidine kinase FOC85_RS22485 ENOG4105KT7 mgtC SapB transporter FOC85_RS22490 ENOG4105VRR gCN5-related N-acetyltransferase FOC85_RS22500 ENOG4105DUU IucA IucC family protein FOC85_RS22505 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_RS22520 ENOG4108WBH protein TIM barrel FOC85_RS22525 ENOG4105YWU small acid-soluble spore protein FOC85_RS22535 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC85_RS22540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS22590 ENOG4105KRN Transcriptional regulator, abrb family FOC85_RS22600 ENOG4105YVS arsR family transcriptional regulator FOC85_RS22605 ENOG4107SET aldo keto reductase FOC85_RS22610 ENOG4107XZQ multidrug resistance protein FOC85_RS22635 ENOG4105C8Q Methyl-accepting chemotaxis FOC85_RS22650 ENOG4108K88 Membrane FOC85_RS22655 ENOG4108WPJ Ferritin-like domain FOC85_RS22670 ENOG4105DEN Luciferase family FOC85_RS22690 ENOG4107QM2 Aldo Keto reductase FOC85_RS22695 ENOG4105CKI cobalamin synthesis protein FOC85_RS22715 ENOG4108IBT Inherit from COG: transposase FOC85_RS22720 ENOG4105DSE periplasmic solute binding protein FOC85_RS22730 ENOG4105K4T epimerase FOC85_RS22740 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC85_RS22765 ENOG4105CVJ phosphoglycerate mutase FOC85_RS22785 ENOG4107T5V SNARE associated Golgi FOC85_RS22800 ENOG4108PJD permease FOC85_RS22810 ENOG4108S4H thioesterase Superfamily protein FOC85_RS22820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC85_RS22840 ENOG4105SXS Protein of unknown function (DUF456) FOC85_RS22845 ENOG4105C37 (CBS) domain FOC85_RS22865 ENOG4108Z7R Chaperone CsaA FOC85_RS22885 ENOG4108ZRV stage ii sporulation protein p FOC85_RS22895 ENOG4108VXD carboxy-peptidase FOC85_RS22925 ENOG4105EFA 4-hydroxyphenylacetate FOC85_RS22935 ENOG4105U1N riboflavin FOC85_RS22950 ENOG4105KME endoribonuclease L-psp FOC85_RS22960 ENOG4105IKQ hydratase FOC85_RS22980 ENOG41069HH 4-oxalocrotonate tautomerase FOC85_RS22990 ENOG4108X4Q Hydrolase FOC85_RS23000 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC85_RS23020 ENOG41087PP glycosyltransferase MGT family FOC85_RS23025 ENOG4108JYZ YitT family FOC85_RS23030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC85_RS23060 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC85_RS23135 ENOG4105KBJ sporulation protein ytfj FOC85_RS23160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC85_RS23185 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC85_RS23195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC85_RS23200 ENOG4105EMN RNA polymerase sigma factor FOC85_RS23215 ENOG4105CNW domain protein FOC85_RS23225 ENOG4108V06 Glutathione peroxidase FOC85_RS23240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC85_RS23260 ENOG4108IUE nitrate reductase beta subunit FOC85_RS23265 ENOG4105R3A Nitrate reductase FOC85_RS23275 ENOG4107V6Q Cyclic nucleotide-binding domain FOC85_RS23280 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC85_RS23285 ENOG4105D06 uba thif-type nad fad binding protein FOC85_RS23295 ENOG4108ZAF Molybdopterin FOC85_RS23315 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC85_RS23320 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC85_RS23325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC85_RS23330 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC85_RS23335 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC85_RS23340 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC85_RS23365 ENOG4105MCT stage V sporulation protein S FOC85_RS23430 ENOG4105C5H ABC transporter FOC85_RS23445 ENOG4108UUM single-stranded DNA-binding protein FOC85_RS23475 ENOG4107YX5 Pfam:DUF548 FOC85_RS23520 ENOG4105C5S asparaginyl-tRNA synthetase FOC85_RS23540 ENOG4105EC2 ftsk spoIIIe FOC85_RS23660 ENOG4105BZW Glycerate kinase FOC85_RS23665 ENOG4107QPK )-transporter FOC85_RS23670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS23675 ENOG41062D9 Histidine kinase FOC85_RS23690 ENOG4105C8J )-transporter FOC85_RS23710 ENOG4107XGZ Hydrolase FOC85_RS23715 ENOG4105CY2 Citrate transporter FOC85_RS23720 ENOG4105C0A alcohol dehydrogenase FOC85_RS23735 ENOG4105KD7 acetyltransferase FOC85_RS23740 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC85_RS23765 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC85_RS23785 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC85_RS23805 ENOG4107RVG penicillin-binding protein FOC85_RS23815 ENOG4105E9Q Acyl-transferase FOC85_RS23820 ENOG4108UT2 hemolysin iii FOC85_RS23830 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC85_RS23840 ENOG4108RCR degv family FOC85_RS23845 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC85_RS23850 ENOG4108KF3 Electron transport protein SCO1 SenC FOC85_RS23855 ENOG4107Y70 Heat shock protein FOC85_RS23860 ENOG4105CAQ asparagine synthetase FOC85_RS23880 ENOG4108MES Periplasmic binding protein FOC85_RS23885 ENOG4105F0I Aminotransferase FOC85_RS23920 ENOG4105D8X mechanosensitive ion channel FOC85_RS23925 ENOG4105BZU Histidine kinase FOC85_RS23930 ENOG4105WH1 Two component transcriptional regulator luxr family FOC85_RS23965 ENOG4105CMG Carbohydrate kinase FOC85_RS23995 ENOG4108IJ8 ABC transporter FOC85_RS24000 ENOG4105E90 ABC transporter FOC85_RS24035 ENOG4105C37 (CBS) domain FOC85_RS24060 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC85_RS24075 ENOG4107S4Y M20 DapE family protein YgeY FOC85_RS24080 ENOG4108TSC N-acetyltransferase FOC85_RS24085 ENOG4108JUB Transcriptional regulator FOC85_RS24090 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC85_RS24130 ENOG4108N23 SpoOM-related protein FOC85_RS24135 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC85_RS24145 ENOG4105SZ6 Thioredoxin FOC85_RS24205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC85_RS24260 ENOG4105BZ4 penicillin-binding protein FOC85_RS24270 ENOG4105W8X HesB YadR YfhF-family protein FOC85_RS24280 ENOG4105DXD 2-methylcitrate dehydratase FOC85_RS24285 ENOG4105CR4 methylisocitrate lyase FOC85_RS24290 ENOG4105C1G acyl-Coa dehydrogenase FOC85_RS24295 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC85_RS24305 ENOG4105N14 lysine exporter protein LysE YggA FOC85_RS24310 ENOG4105E39 Enoyl-CoA hydratase FOC85_RS24325 ENOG4107RFY SbcCD D subunit FOC85_RS24330 ENOG4105EYH Exonuclease FOC85_RS24350 ENOG4105FCD Major Facilitator FOC85_RS24355 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC85_RS24360 ENOG4105E4F Isochorismate synthase FOC85_RS24365 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC85_RS24370 ENOG4105WQI isochorismatase FOC85_RS24375 ENOG4105CEY Amp-dependent synthetase and ligase FOC85_RS24380 ENOG4105WQT MbtH domain protein FOC85_RS24385 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC85_RS24400 ENOG4105K70 DNA-binding protein FOC85_RS24420 ENOG4105BZG amino acid carrier protein FOC85_RS24440 ENOG4105FE9 pseudouridine synthase FOC85_RS24445 ENOG4105C22 threonyL-tRNA synthetase FOC85_RS24455 ENOG4105C19 ABC transporter FOC85_RS24465 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC85_RS24490 ENOG4108D32 Methyltransferase FOC85_RS24520 ENOG41081I9 integral membrane protein FOC85_RS24535 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC85_RS24545 ENOG4105EYF MMPL domain protein FOC85_RS24570 ENOG4105WCN acetyltransferase FOC85_RS24600 ENOG4105C1Q protoporphyrinogen oxidase FOC85_RS24610 ENOG41089UC methyltransferase, type 11 FOC85_RS24615 ENOG41068WN FOC85_RS24625 ENOG4105VEQ Cold shock protein FOC85_RS24650 ENOG4107V2S Transcriptional regulator FOC85_RS24655 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC85_RS24670 ENOG4105DND Transcriptional regulator FOC85_RS24675 ENOG4108RPX mosc domain containing protein FOC85_RS24690 ENOG4105BZ1 (ABC) transporter FOC85_RS24695 ENOG4105BZ1 (ABC) transporter FOC85_RS24715 ENOG4108JCI Transcriptional regulator FOC85_RS24745 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC85_RS24755 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC85_RS24760 ENOG4108KPJ rna polymerase sigma factor FOC85_RS24785 ENOG4105F32 YngK protein FOC85_RS24810 ENOG4105RD7 BadF BadG BcrA BcrD FOC85_RS24820 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC85_RS24855 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC85_RS24870 ENOG4105C1J atp-dependent rna helicase FOC85_RS24945 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC85_RS24970 ENOG41088CC tellurite resistance protein tehB FOC85_RS25065 ENOG41090HR transcriptional regulator FOC85_RS25100 ENOG4105CIN aminoacyl-histidine dipeptidase FOC85_RS25110 ENOG4105EQK -acetyltransferase FOC85_RS25125 ENOG4107RVG penicillin-binding protein FOC85_RS25140 ENOG4107RF6 penicillin-binding protein FOC85_RS25145 ENOG4107RF6 penicillin-binding protein FOC85_RS25160 ENOG4105ETE Transcriptional regulator (LacI family FOC85_RS25165 ENOG4105IE8 Alpha-ketoglutarate permease FOC85_RS25170 ENOG4105CK5 oxidoreductase FOC85_RS25195 ENOG4105D2N Aldolase FOC85_RS25200 ENOG4105DH8 myo-inositol catabolism FOC85_RS25225 ENOG4105CGH 5'-nucleotidase FOC85_RS25235 ENOG4107JM4 Tetratricopeptide repeat FOC85_RS25240 ENOG4105VZ8 Transcriptional regulator FOC85_RS25255 ENOG4108VXD carboxy-peptidase FOC85_RS25270 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC85_RS25275 ENOG41067SE Tetr family transcriptional regulator FOC85_RS25280 ENOG4105C5H ABC transporter FOC85_RS25315 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC85_RS25345 ENOG4105C1G acyl-Coa dehydrogenase FOC85_RS25350 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC85_RS25355 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC85_RS25360 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC85_RS25365 ENOG4105E39 Enoyl-CoA hydratase FOC85_RS25370 ENOG4107QX3 carboxylase FOC85_RS25375 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC85_RS25385 ENOG4105WCN acetyltransferase FOC85_RS25390 ENOG4105DBI uridine monophosphokinase FOC85_RS25420 ENOG4105T9C HD domain FOC85_RS25430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC85_RS25470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_RS25470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC85_RS25515 ENOG4105CUV Homoserine Kinase FOC85_RS25575 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC85_RS25585 ENOG4105DK7 lysyl-tRNA synthetase FOC85_RS25670 ENOG4105ETU transcriptional activator (TenA FOC85_RS25780 ENOG410667J hydrolase FOC85_RS25785 ENOG4105BZU Histidine kinase FOC85_RS25790 ENOG4107RF6 penicillin-binding protein FOC85_RS25825 ENOG4108HGU Histidine kinase FOC85_RS25835 ENOG4105RHY Pfam:UPF0157 FOC85_RS25840 ENOG4105CB2 alcohol dehydrogenase FOC85_RS25845 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC85_RS25850 ENOG4105CJN penicillin-binding protein FOC85_RS25855 ENOG4108IG5 Transcriptional regulator FOC85_RS25860 ENOG4107GJV short-chain dehydrogenase reductase FOC85_RS25870 ENOG4105FQP Beta-lactamase FOC85_RS25910 ENOG4108V4B ThiJ pfpI FOC85_RS25925 ENOG4107Y80 Major Facilitator superfamily FOC85_RS25940 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC85_RS25965 ENOG4107Y9U Membrane FOC85_RS26000 ENOG4105FCD Major Facilitator FOC85_RS26005 ENOG4105E09 nadh pyrophosphatase FOC85_RS26010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC85_RS26015 ENOG4108Z4K mutator MutT protein FOC85_RS26035 ENOG4107TB6 phosphoglycerate mutase FOC85_RS26045 ENOG4108XI2 Domain of unknown function (DUF1963) FOC85_RS26065 ENOG4108NRW Phospholipase, patatin family FOC85_RS26070 ENOG4105KWG Pfam:DUF1696 FOC85_RS26105 ENOG4105PKS Excinuclease abc c subunit domain protein FOC85_RS26140 ENOG4107VFR oxidoreductase FOC85_RS26185 ENOG4108IUM Glycogen debranching enzyme FOC85_RS26210 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC85_RS26215 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC85_RS26225 ENOG4105FDR Membrane FOC85_RS26280 ENOG4105MSI germination protein ypeb FOC85_RS26315 ENOG4107Z3H Transcriptional regulator, TetR family FOC85_RS26350 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC85_RS26365 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC85_RS26370 ENOG4105E98 transcriptional regulator DeoR family FOC85_RS26390 ENOG41062ES Transcriptional regulator FOC85_RS26410 ENOG4107QKR Dehydrogenase FOC85_RS26420 ENOG4107RUY (E1 component), alpha subunit FOC85_RS26430 ENOG4105E1F short-chain dehydrogenase reductase FOC85_RS26435 ENOG4105RHY Pfam:UPF0157 FOC85_RS26440 ENOG4105DBI uridine monophosphokinase FOC85_RS26450 ENOG4105M6F mutator MutT protein FOC85_RS26475 ENOG4107SQ8 Glycine betaine FOC85_RS26480 ENOG4108IJ7 Glycine betaine FOC85_RS26505 ENOG4105E66 phosphoriboisomerase A FOC85_RS26510 ENOG41082BV acetyltransferase FOC85_RS26515 ENOG4108M1A Chitin-binding protein FOC85_RS26530 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC85_RS26535 ENOG4105MSB protein, conserved in bacteria FOC85_RS26540 ENOG4107YB6 acetyltransferase, (GNAT) family FOC85_RS26545 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC85_RS26575 ENOG4108Z7F N-acetyltransferase FOC85_RS26595 ENOG4105EEM helicase FOC85_RS26615 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC85_RS26665 ENOG4108M1A Chitin-binding protein FOC85_RS26685 ENOG4105BZG amino acid carrier protein FOC85_RS26690 ENOG4105C26 Dehydrogenase FOC85_RS26695 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC85_RS26700 ENOG4105CTU Proline racemase FOC85_RS26705 ENOG4105CTU Proline racemase FOC85_RS26710 ENOG41080HI glycine oxidase FOC85_RS26720 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC85_RS26750 ENOG4107T5V SNARE associated Golgi FOC85_RS26765 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC85_RS26770 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC85_RS26785 ENOG4105DTQ mandelate racemase muconate lactonizing FOC85_RS26830 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC85_RS26835 ENOG4105BZU Histidine kinase FOC85_RS26840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC85_RS26870 ENOG4105DPN Oligoendopeptidase f FOC85_RS26875 ENOG4105DVH amino acid FOC85_RS26885 ENOG4105EPR degv family FOC85_RS26945 ENOG4106K7D Major facilitator family transporter FOC85_RS26965 ENOG4107BMA Transglycosylase associated protein FOC85_RS26980 ENOG41089UC methyltransferase, type 11 FOC85_RS27010 ENOG4105CHM Aminotransferase FOC85_RS27025 ENOG4108ZMI UPF0477 protein FOC85_RS27040 ENOG4105DVE abc transporter atp-binding protein FOC85_RS27085 ENOG4105C02 permease FOC85_RS27095 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC85_RS27100 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC85_RS27105 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC85_RS27120 ENOG4105E09 nadh pyrophosphatase FOC85_RS27140 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC85_RS27210 ENOG4108ZCF integral membrane protein FOC85_RS27215 ENOG4105E0M Sulfatase FOC85_RS27220 ENOG4105C5H ABC transporter FOC85_RS27230 ENOG4105EYF MMPL domain protein FOC85_RS27235 ENOG41082JN Transcriptional regulator FOC85_RS27255 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC85_RS27265 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC85_RS27285 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC85_RS27305 ENOG41069ER domain protein FOC85_RS27315 ENOG4105CY2 Citrate transporter FOC85_RS27320 ENOG4105E39 Enoyl-CoA hydratase FOC85_RS27325 ENOG4105J5T Amp-dependent synthetase and ligase FOC85_RS27330 ENOG4108JUB Transcriptional regulator FOC85_RS27345 ENOG4105D4B ABC, transporter FOC85_RS27350 ENOG4105F5R ABC transporter FOC85_RS27355 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC85_RS27365 ENOG4105DKT Transcriptional regulator FOC85_RS27370 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC85_RS27380 ENOG41061GT Aldolase FOC85_RS27405 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC85_RS27440 ENOG4105II7 pyrroline-5-carboxylate reductase FOC85_RS27450 ENOG4107258 Transcriptional regulator FOC85_RS27460 ENOG4105E0Y RtcB Protein FOC85_RS27465 ENOG4105ECK Fatty Acid Desaturase