locus-tag class description FOC87_RS00020 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC87_RS00025 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC87_RS00040 ENOG4105C2M dna polymerase I FOC87_RS00045 ENOG4105BZU Histidine kinase FOC87_RS00050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS00070 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC87_RS00075 ENOG4105BZN citrate synthase FOC87_RS00085 ENOG4108REF Sporulation integral membrane protein ytvi FOC87_RS00090 ENOG4105FS0 cytoplasmic membrane protein FOC87_RS00115 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS00120 ENOG4105C6K Malic enzyme FOC87_RS00125 ENOG4105C0B DNA polymerase III (alpha subunit) FOC87_RS00130 ENOG4105VV2 FOC87_RS00140 ENOG4105SFS phosphoesterase RecJ domain protein FOC87_RS00180 ENOG4105DC7 peptidase M24 FOC87_RS00225 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC87_RS00235 ENOG4105VZ8 Transcriptional regulator FOC87_RS00255 ENOG4107YZX Universal stress protein FOC87_RS00295 ENOG4108JYZ YitT family FOC87_RS00310 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC87_RS00320 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC87_RS00325 ENOG4105KBJ sporulation protein ytfj FOC87_RS00340 ENOG4105EFZ amidohydrolase FOC87_RS00350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC87_RS00375 ENOG4106KR7 LysR family Transcriptional regulator FOC87_RS00385 ENOG4105U5Y Transcriptional regulator FOC87_RS00395 ENOG4105C28 cystathionine FOC87_RS00445 ENOG4105EMN RNA polymerase sigma factor FOC87_RS00460 ENOG4105F1V Acetoin utilization protein FOC87_RS00465 ENOG4105W87 Cbs domain FOC87_RS00470 ENOG4105DGU Histone deacetylase FOC87_RS00485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS00495 ENOG4107SNB ankyrin repeat protein YahD FOC87_RS00500 ENOG4105EP9 oxidoreductase FOC87_RS00530 ENOG4105ETE Transcriptional regulator (LacI family FOC87_RS00550 ENOG4105C88 aminopeptidase FOC87_RS00595 ENOG4108VDD TRNA binding domain protein FOC87_RS00625 ENOG4105C8F Beta-lactamase domain protein FOC87_RS00640 ENOG4108V15 phosphotransferase enzyme family FOC87_RS00645 ENOG4108IUM Glycogen debranching enzyme FOC87_RS00655 ENOG4107QSE Dipeptidase FOC87_RS00660 ENOG4105YW5 deoR family transcriptional regulator FOC87_RS00675 ENOG4105CBX hi0933 family FOC87_RS00710 ENOG4108VJ1 Transcriptional regulator (CarD family FOC87_RS00715 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC87_RS00735 ENOG4108ZAF Molybdopterin FOC87_RS00740 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC87_RS00745 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC87_RS00755 ENOG4105D06 uba thif-type nad fad binding protein FOC87_RS00760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC87_RS00780 ENOG41085GJ domain protein FOC87_RS00790 ENOG4105DWV Homoserine O-trans-acetylase FOC87_RS00800 ENOG4108B31 Spore germination protein FOC87_RS00835 ENOG410605W Major Facilitator FOC87_RS00840 ENOG4107S91 Sodium hydrogen exchanger FOC87_RS00845 ENOG4105NCW Trka-c domain protein FOC87_RS00860 ENOG4105C19 ABC transporter FOC87_RS00880 ENOG4105N5T Radical SAM Protein FOC87_RS00890 ENOG4105CIG ABC transporter FOC87_RS00935 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC87_RS00940 ENOG4108Z0R Transferase FOC87_RS00945 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC87_RS00950 ENOG4105BZF Glycosyl transferase (Group 1 FOC87_RS00960 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC87_RS01025 ENOG4107XGZ Hydrolase FOC87_RS01030 ENOG4105E98 transcriptional regulator DeoR family FOC87_RS01040 ENOG4105BZU Histidine kinase FOC87_RS01045 ENOG4105BZU Histidine kinase FOC87_RS01050 ENOG4107S9D Alpha beta hydrolase FOC87_RS01055 ENOG4107T7U Sulfatase FOC87_RS01070 ENOG4105D2X ABC transporter substrate-binding protein FOC87_RS01080 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC87_RS01095 ENOG4107XGZ Hydrolase FOC87_RS01140 ENOG4108V2W Carbonate dehydratase FOC87_RS01145 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC87_RS01150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC87_RS01195 ENOG41087YS Phage shock protein A FOC87_RS01255 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC87_RS01260 ENOG4105BZU Histidine kinase FOC87_RS01265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS01290 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC87_RS01295 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC87_RS01305 ENOG4105D7V transposase FOC87_RS01325 ENOG4107ZTW SNARE associated Golgi FOC87_RS01335 ENOG41063TF transcriptional regulator (AraC FOC87_RS01350 ENOG4105C19 ABC transporter FOC87_RS01355 ENOG41086D8 Transcriptional regulator FOC87_RS01395 ENOG4105C6Z Gluconate FOC87_RS01420 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC87_RS01440 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_RS01450 ENOG4108IPT Naphthoate synthase FOC87_RS01455 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC87_RS01465 ENOG4105E4F Isochorismate synthase FOC87_RS01470 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC87_RS01480 ENOG4105VEQ Cold shock protein FOC87_RS01525 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_RS01625 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC87_RS01660 ENOG4105KT7 mgtC SapB transporter FOC87_RS01665 ENOG4107PBV potassium channel FOC87_RS01680 ENOG4105WG9 Conserved Protein FOC87_RS01690 ENOG4105CHM Aminotransferase FOC87_RS01695 ENOG4108ZB6 transcriptional regulator AsnC family FOC87_RS01700 ENOG4105C5I Dehydrogenase FOC87_RS01705 ENOG4108MUZ hydrolase FOC87_RS01715 ENOG4105C87 Aminotransferase class I and II FOC87_RS01730 ENOG4105Y38 Kinase-associated protein B FOC87_RS01740 ENOG4107R3E Citrate transporter FOC87_RS01760 ENOG4105KA0 thioesterase Superfamily protein FOC87_RS01775 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC87_RS01795 ENOG41069ER domain protein FOC87_RS01810 ENOG4105CEP NADH dehydrogenase FOC87_RS01840 ENOG4105EWC Purine nucleoside phosphorylase FOC87_RS01850 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC87_RS01875 ENOG4108JJA ABC, transporter FOC87_RS01880 ENOG4105C4B ABC transporter, permease FOC87_RS01885 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC87_RS01910 ENOG41083MR nifu domain-containing protein FOC87_RS01925 ENOG4108W5N phosphatidylglycerophosphatase a FOC87_RS01940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_RS01945 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC87_RS01950 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC87_RS01965 ENOG4105CBT Fructose-1,6-bisphosphatase FOC87_RS01980 ENOG4105MMD transcriptional regulator FOC87_RS01985 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC87_RS01990 ENOG4107TXC Transcriptional regulator FOC87_RS01995 ENOG41090T1 Membrane FOC87_RS02020 ENOG4105FAA peptidase M23 FOC87_RS02030 ENOG4105KZD Domain of unknown function (DUF1805) FOC87_RS02035 ENOG4107R8B 5'-nucleotidase FOC87_RS02050 ENOG4105DIW FeS assembly protein SUFB FOC87_RS02055 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC87_RS02060 ENOG4105C9B Cysteine desulfurase FOC87_RS02065 ENOG4105JRK feS assembly protein SufD FOC87_RS02070 ENOG4105C3K feS assembly ATPase SufC FOC87_RS02075 ENOG4105D01 (LipO)protein FOC87_RS02080 ENOG4105D01 (LipO)protein FOC87_RS02085 ENOG4108UMI ABC transporter, permease FOC87_RS02115 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC87_RS02160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC87_RS02185 ENOG4108IMY Transcriptional regulator FOC87_RS02195 ENOG4108W8B Beta-lactamase domain protein FOC87_RS02205 ENOG4108IUW ABC transporter FOC87_RS02230 ENOG4105C1G acyl-Coa dehydrogenase FOC87_RS02235 ENOG4105CHU acetyl-coa acetyltransferase FOC87_RS02250 ENOG4105DZ1 carboxypeptidase FOC87_RS02270 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_RS02290 ENOG4108SUT Major Facilitator Superfamily FOC87_RS02295 ENOG4107R7I amino acid FOC87_RS02310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC87_RS02320 ENOG4107AYK membrAne FOC87_RS02355 ENOG4107ZTW SNARE associated Golgi FOC87_RS02365 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC87_RS02370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS02375 ENOG4105BZU Histidine kinase FOC87_RS02395 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_RS02400 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_RS02405 ENOG4105VG1 fes assembly suf system protein FOC87_RS02410 ENOG4105D4Y metalloprotease FOC87_RS02430 ENOG4107S91 Sodium hydrogen exchanger FOC87_RS02435 ENOG4105NCW Trka-c domain protein FOC87_RS02445 ENOG4108RMU ferritin dps family protein FOC87_RS02460 ENOG4108URH decarboxylase FOC87_RS02480 ENOG4105D9N nucleoside FOC87_RS02485 ENOG4105D9N nucleoside FOC87_RS02500 ENOG4108RYK Nad-dependent epimerase dehydratase FOC87_RS02515 ENOG4105CV8 reductase FOC87_RS02520 ENOG4105F27 Major Facilitator FOC87_RS02525 ENOG4105KVH Transcriptional regulator FOC87_RS02540 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC87_RS02565 ENOG4105WMR Protein CrcB homolog FOC87_RS02590 ENOG4105C5H ABC transporter FOC87_RS02595 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC87_RS02615 ENOG4108IPW abc transporter atp-binding protein FOC87_RS02620 ENOG4105CM4 permease protein FOC87_RS02635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS02650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC87_RS02660 ENOG4105XZU Preprotein translocase, subunit SecG FOC87_RS02665 ENOG41067MG lrgb family FOC87_RS02715 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS02735 ENOG41090VF Stage v sporulation protein ac FOC87_RS02740 ENOG4105CZ3 stage V sporulation protein ad FOC87_RS02755 ENOG4105H67 Protein of unknown function (DUF421) FOC87_RS02765 ENOG4105KRI phosphocarrier protein (HPr FOC87_RS02775 ENOG4105CHW UPF0052 protein FOC87_RS02785 ENOG4108Z4K mutator MutT protein FOC87_RS02795 ENOG4105C3M thioredoxin reductase FOC87_RS02805 ENOG4108S4C acetyltransferase FOC87_RS02825 ENOG41086DT Membrane protein of unknown function FOC87_RS02875 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_RS02880 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC87_RS02895 ENOG4107TXC Transcriptional regulator FOC87_RS02920 ENOG4105HMI Membrane FOC87_RS02925 ENOG4105DUM transcriptional regulator, lysR family FOC87_RS02935 ENOG4108WS4 fmn reductase FOC87_RS02940 ENOG4105C5H ABC transporter FOC87_RS02950 ENOG4105BZ1 (ABC) transporter FOC87_RS02960 ENOG4105CN1 protease FOC87_RS02965 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC87_RS02970 ENOG4105CAK Cell division ATP-binding protein ftsE FOC87_RS02990 ENOG4105MS2 ribosomal subunit Interface protein FOC87_RS02995 ENOG4105VEQ Cold shock protein FOC87_RS03000 ENOG41081UC Inherit from COG: Competence protein FOC87_RS03015 ENOG4105KVH Transcriptional regulator FOC87_RS03025 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC87_RS03030 ENOG4108KGH TRANSCRIPTIONal FOC87_RS03035 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC87_RS03040 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC87_RS03045 ENOG4105ESV Glycosyl transferase, family 4 FOC87_RS03055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC87_RS03075 ENOG4105F8D glycoside hydrolase family 4 FOC87_RS03080 ENOG4105VCP PTS System FOC87_RS03085 ENOG4105CK1 PTS System FOC87_RS03095 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC87_RS03115 ENOG4105VCP PTS System FOC87_RS03125 ENOG4105VZJ PTS System FOC87_RS03140 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC87_RS03160 ENOG4105ECB domain protein FOC87_RS03165 ENOG4107RSM transcriptional regulator FOC87_RS03200 ENOG4105DAA L-lactate FOC87_RS03205 ENOG4105D7V transposase FOC87_RS03215 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC87_RS03225 ENOG4105E0M Sulfatase FOC87_RS03250 ENOG4107R8N Glycosyl transferase, family 2 FOC87_RS03255 ENOG4105C94 Transporter FOC87_RS03260 ENOG41069ER domain protein FOC87_RS03285 ENOG4105KBK Zinc finger, swim domain protein FOC87_RS03290 ENOG4105C0D helicase FOC87_RS03320 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS03335 ENOG4107RBB ABC transporter, permease FOC87_RS03340 ENOG4105C19 ABC transporter FOC87_RS03360 ENOG4105CXY transporter FOC87_RS03380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS03385 ENOG4105DG6 mannose-6-phosphate isomerase FOC87_RS03390 ENOG4105DM4 PTS System FOC87_RS03400 ENOG4105CMR udp-glucose 4-epimerase FOC87_RS03410 ENOG4108KGH TRANSCRIPTIONal FOC87_RS03415 ENOG4105DG6 mannose-6-phosphate isomerase FOC87_RS03420 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC87_RS03425 ENOG4105CPK Glycosyl transferase (Group 1 FOC87_RS03430 ENOG4108TJN glycosyl transferase group 1 FOC87_RS03435 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC87_RS03455 ENOG4105D3Q Sugar transferase FOC87_RS03460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC87_RS03465 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC87_RS03470 ENOG4107YJ4 chain length determinant protein FOC87_RS03475 ENOG4105HTX biosynthesis protein FOC87_RS03480 ENOG4107YJ4 chain length determinant protein FOC87_RS03495 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC87_RS03505 ENOG4105FRN stage II sporulation protein FOC87_RS03520 ENOG4105DY9 regulatoR FOC87_RS03540 ENOG4106778 Protein of unknown function (DUF1146) FOC87_RS03545 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC87_RS03550 ENOG4105C8S subunit m FOC87_RS03555 ENOG4105D65 subunit l FOC87_RS03585 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC87_RS03600 ENOG4105BZU Histidine kinase FOC87_RS03650 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC87_RS03655 ENOG41062M3 atp synthase FOC87_RS03685 ENOG4108YZG isomerase FOC87_RS03700 ENOG4108VGI doxx family FOC87_RS03705 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC87_RS03720 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC87_RS03730 ENOG4108ZXQ stage ii sporulation protein r FOC87_RS03735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC87_RS03755 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC87_RS03760 ENOG4105CBT Fructose-1,6-bisphosphatase FOC87_RS03800 ENOG4105C1G acyl-Coa dehydrogenase FOC87_RS03805 ENOG4105C1G acyl-Coa dehydrogenase FOC87_RS03810 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC87_RS03820 ENOG4105DF6 Fe-S oxidoreductase FOC87_RS03835 ENOG4105BZU Histidine kinase FOC87_RS03860 ENOG4105BZU Histidine kinase FOC87_RS03865 ENOG4105KCT ABC transporter FOC87_RS03870 ENOG4108M15 ABC transporter FOC87_RS03875 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_RS03885 ENOG4105IIU Aminopeptidase FOC87_RS03905 ENOG4105EMN RNA polymerase sigma factor FOC87_RS03915 ENOG410684U Domain of unknown function (DUF1934) FOC87_RS03935 ENOG4105CYW agmatinase FOC87_RS03945 ENOG4105DXB Major Facilitator superfamily FOC87_RS03950 ENOG4107SWG transcriptional regulator MERR family FOC87_RS03955 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_RS03960 ENOG4105BZ4 penicillin-binding protein FOC87_RS03965 ENOG4108XFG YwhD family FOC87_RS03970 ENOG4108Z4T Peptidase M50 FOC87_RS03975 ENOG41069HH 4-oxalocrotonate tautomerase FOC87_RS03980 ENOG4105DCI Phosphohydrolase FOC87_RS03985 ENOG4108MES Periplasmic binding protein FOC87_RS03990 ENOG4105E0A ABC, transporter FOC87_RS03995 ENOG4105EHG Permease protein FOC87_RS04000 ENOG4105DQ5 transport system permease protein FOC87_RS04010 ENOG4108VCI transcription factor, rsfa family FOC87_RS04025 ENOG4108IJ2 phosphate acetyltransferase FOC87_RS04040 ENOG4108VKI Cell wall hydrolase FOC87_RS04060 ENOG4107SVH Potassium channel protein FOC87_RS04070 ENOG410667J hydrolase FOC87_RS04075 ENOG4105VCH membrane FOC87_RS04085 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC87_RS04090 ENOG4105CJ1 ABC, transporter FOC87_RS04095 ENOG41090WU lipolytic protein G-D-S-L family FOC87_RS04110 ENOG4105D6E homoserine dehydrogenase FOC87_RS04130 ENOG4108Y4K DNA-binding transcriptional activator FOC87_RS04140 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_RS04145 ENOG4105BZU Histidine kinase FOC87_RS04150 ENOG4105DWF phosphomethylpyrimidine kinase FOC87_RS04155 ENOG4105BZU Histidine kinase FOC87_RS04160 ENOG4105VCD cytoplasmic protein FOC87_RS04165 ENOG4105D22 carbon starvation protein FOC87_RS04170 ENOG4105DY9 regulatoR FOC87_RS04175 ENOG41079KZ Major Facilitator Superfamily FOC87_RS04195 ENOG4105EN6 Membrane FOC87_RS04200 ENOG4106YBV Methyl-accepting chemotaxis FOC87_RS04210 ENOG4108S4H thioesterase Superfamily protein FOC87_RS04220 ENOG4105JEU Glycosyl transferase, family 2 FOC87_RS04225 ENOG4105C5H ABC transporter FOC87_RS04245 ENOG4105CKK Glycosyl transferase, family 2 FOC87_RS04250 ENOG41067SE Tetr family transcriptional regulator FOC87_RS04260 ENOG4105E0X reductase FOC87_RS04265 ENOG4106F5Q Membrane FOC87_RS04280 ENOG4105DY9 regulatoR FOC87_RS04285 ENOG4108HRK Histidine kinase FOC87_RS04290 ENOG4107RGD Major Facilitator superfamily FOC87_RS04305 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_RS04315 ENOG4105IW1 AmiS UreI transporter FOC87_RS04325 ENOG4105CMR udp-glucose 4-epimerase FOC87_RS04330 ENOG4108UT2 hemolysin iii FOC87_RS04340 ENOG4105C1J atp-dependent rna helicase FOC87_RS04355 ENOG4105DPN Oligoendopeptidase f FOC87_RS04375 ENOG4105C0H protease FOC87_RS04380 ENOG4105Q2H domain protein FOC87_RS04395 ENOG4105BZU Histidine kinase FOC87_RS04400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS04430 ENOG4105CDU Replicative dna helicase FOC87_RS04440 ENOG4105BZR domain protein FOC87_RS04445 ENOG4108XMW Membrane FOC87_RS04455 ENOG4108UUM single-stranded DNA-binding protein FOC87_RS04465 ENOG4105C3G gtp-binding protein FOC87_RS04470 ENOG4105VDK protein, conserved in bacteria FOC87_RS04475 ENOG4105D8X mechanosensitive ion channel FOC87_RS04480 ENOG4108ZDA Sporulation protein YyaC FOC87_RS04485 ENOG4105FA0 parb-like partition protein FOC87_RS04490 ENOG4107QJE Chromosome Partitioning Protein FOC87_RS04520 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC87_RS04540 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC87_RS04545 ENOG410848D S4 domain protein YaaA FOC87_RS04560 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC87_RS04595 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC87_RS04630 ENOG4105ZMH deoxynucleoside kinase FOC87_RS04640 ENOG4105GTG Isochorismatase FOC87_RS04645 ENOG4108Z6B deaminase FOC87_RS04655 ENOG4105C6E dna polymerase iii FOC87_RS04675 ENOG41067KS pro-sigma K processing FOC87_RS04710 ENOG4105CXN decarboxylase FOC87_RS04720 ENOG4105FA2 dna polymerase iii FOC87_RS04725 ENOG4105MA4 psp1 domain protein FOC87_RS04735 ENOG41060K3 Methyltransferase FOC87_RS04745 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC87_RS04750 ENOG4105KRN Transcriptional regulator, abrb family FOC87_RS04760 ENOG4105F8V Hydrolase, tatD family FOC87_RS04765 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC87_RS04775 ENOG4105XFA sporulation peptidase YabG FOC87_RS04780 ENOG4105W42 Veg protein FOC87_RS04795 ENOG4105DFT pur operon repressor FOC87_RS04800 ENOG4105KME endoribonuclease L-psp FOC87_RS04830 ENOG4108JA2 transcriptioN-repair coupling factor FOC87_RS04835 ENOG4108M14 stage v sporulation protein t FOC87_RS04845 ENOG4108IY2 MazG family FOC87_RS04850 ENOG41082I2 s4 domain protein FOC87_RS04855 ENOG4105VYY sporulation protein yabp FOC87_RS04870 ENOG41060GV RNA binding s1 domain protein FOC87_RS04895 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC87_RS04900 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC87_RS04915 ENOG4105C6T cysteine synthase FOC87_RS04920 ENOG4105CRQ synthase (Component I) FOC87_RS04925 ENOG4105DDQ anthranilate synthase FOC87_RS04930 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC87_RS04935 ENOG4105EEI dihydropteroate synthase FOC87_RS04940 ENOG4105KRF dihydroneopterin aldolase FOC87_RS04945 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC87_RS04955 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC87_RS05045 ENOG4108Z0C Uvrb UvrC protein FOC87_RS05060 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC87_RS05070 ENOG4105CTP PilT protein domain protein FOC87_RS05090 ENOG4105D7W serine acetyltransferase FOC87_RS05105 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC87_RS05110 ENOG4105M0M Tetracycline resistance protein FOC87_RS05115 ENOG4105QIV RNA polymerase FOC87_RS05130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC87_RS05155 ENOG4107Y49 methyltransferase FOC87_RS05170 ENOG4105XPM ribosomal protein FOC87_RS05300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC87_RS05310 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_RS05355 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC87_RS05385 ENOG4105D1F ATP-binding protein FOC87_RS05400 ENOG4108NMV polysaccharide deacetylase FOC87_RS05480 ENOG4105C8B TIGR00159 family FOC87_RS05485 ENOG4107U5W ybbr family FOC87_RS05520 ENOG4105CMG Carbohydrate kinase FOC87_RS05530 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC87_RS05535 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC87_RS05575 ENOG4108PSK reductase FOC87_RS05580 ENOG4108UMI ABC transporter, permease FOC87_RS05585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC87_RS05590 ENOG4105D01 (LipO)protein FOC87_RS05605 ENOG4105IQ5 FAD linked oxidase domain protein FOC87_RS05620 ENOG4105C2C drug resistance transporter, Bcr CflA FOC87_RS05635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_RS05640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_RS05645 ENOG4105C3U ABC transporter FOC87_RS05650 ENOG4108JQ7 (ABC) transporter FOC87_RS05675 ENOG4105U5Y Transcriptional regulator FOC87_RS05685 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC87_RS05690 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC87_RS05700 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_RS05705 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC87_RS05715 ENOG4105E0C molybdate abc transporter FOC87_RS05720 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC87_RS05725 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC87_RS05755 ENOG4105F6E Acyl-transferase FOC87_RS05775 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC87_RS05785 ENOG4108RE7 deoxyribonuclease FOC87_RS05795 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC87_RS05820 ENOG4105C5H ABC transporter FOC87_RS05835 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC87_RS05845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_RS05850 ENOG4105C3U ABC transporter FOC87_RS05855 ENOG4108JQ7 (ABC) transporter FOC87_RS05860 ENOG410667J hydrolase FOC87_RS05890 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC87_RS05895 ENOG4105ERH Fumarylacetoacetate hydrolase FOC87_RS05905 ENOG4105CUB amino acid FOC87_RS05910 ENOG4108SC4 )-transporter FOC87_RS05915 ENOG4105CPF Cell wall formation (By similarity) FOC87_RS05920 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC87_RS05935 ENOG4107ZXI Rhomboid family FOC87_RS05945 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC87_RS05950 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC87_RS05960 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC87_RS06060 ENOG4105K8N protein family UPF0079, ATPase FOC87_RS06065 ENOG41072GX Peptidase M22 Glycoprotease FOC87_RS06070 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC87_RS06080 ENOG4105C5H ABC transporter FOC87_RS06095 ENOG4108TYN CAAX amino terminal protease family protein FOC87_RS06110 ENOG4107EV6 Inherit from COG: YD repeat protein FOC87_RS06130 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC87_RS06170 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_RS06180 ENOG4105BZU Histidine kinase FOC87_RS06205 ENOG4107ZXU DSBA oxidoreductase FOC87_RS06280 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS06300 ENOG4105SX7 Transporter FOC87_RS06325 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC87_RS06330 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC87_RS06335 ENOG4105C83 adenylosuccinate lyase FOC87_RS06345 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC87_RS06370 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC87_RS06380 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC87_RS06405 ENOG4105C4R Atp-dependent dna helicase FOC87_RS06435 ENOG4108W2Y isochorismatase FOC87_RS06440 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC87_RS06445 ENOG4108UMI ABC transporter, permease FOC87_RS06450 ENOG4105D01 (LipO)protein FOC87_RS06480 ENOG410834F Transcriptional regulator FOC87_RS06485 ENOG4107I77 yiaA/B two helix domain FOC87_RS06505 ENOG4105CBD Diacylglycerol kinase FOC87_RS06510 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC87_RS06515 ENOG4108JPW Aminotransferase FOC87_RS06525 ENOG4105C26 Dehydrogenase FOC87_RS06530 ENOG4105KPY Small multidrug resistance protein FOC87_RS06550 ENOG4105D9N nucleoside FOC87_RS06555 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC87_RS06565 ENOG4105BZU Histidine kinase FOC87_RS06570 ENOG4108W15 Protein of unknown function (DUF1456) FOC87_RS06585 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_RS06595 ENOG4105DFD Na H antiporter FOC87_RS06615 ENOG4105D3R alkyl hydroperoxide reductase FOC87_RS06635 ENOG4105EHG Permease protein FOC87_RS06640 ENOG4105DQ5 transport system permease protein FOC87_RS06645 ENOG4108V5C ABC transporter FOC87_RS06665 ENOG4106UIA FOC87_RS06670 ENOG4106UIA FOC87_RS06690 ENOG4105BZU Histidine kinase FOC87_RS06710 ENOG410756H nucleotidyltransferase FOC87_RS06715 ENOG4105D2S major facilitator superfamily FOC87_RS06735 ENOG4105EAB amino acid AbC transporter FOC87_RS06745 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_RS06760 ENOG4105DBV ornithine carbamoyltransferase FOC87_RS06770 ENOG4105C5B carbamate kinase FOC87_RS06795 ENOG4105CI1 PTS System FOC87_RS06825 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC87_RS06840 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC87_RS06885 ENOG41062JF Transcriptional regulator FOC87_RS06905 ENOG4105DEU major facilitator superfamily FOC87_RS06935 ENOG4108N0M stress protein FOC87_RS06940 ENOG4106FN3 tellurium resistance protein FOC87_RS06945 ENOG4106FN3 tellurium resistance protein FOC87_RS06950 ENOG4107TS3 membrane protein, TerC FOC87_RS06955 ENOG4108TTB tellurium resistance protein FOC87_RS06975 ENOG4105KJF protein tyrosine phosphatase FOC87_RS06985 ENOG4107U9T Pfam:Ribonuclease_BN FOC87_RS06990 ENOG4105C59 p-type ATPase FOC87_RS06995 ENOG4108IPJ Membrane FOC87_RS07015 ENOG4107ZTW SNARE associated Golgi FOC87_RS07030 ENOG410606W general stress protein FOC87_RS07035 ENOG4105UPD Calcium Proton FOC87_RS07085 ENOG4108JUB Transcriptional regulator FOC87_RS07095 ENOG4108IQI permease FOC87_RS07135 ENOG4108A04 Beta-lactamase FOC87_RS07150 ENOG4105CKK Glycosyl transferase, family 2 FOC87_RS07155 ENOG4107QQG Dehydrogenase FOC87_RS07160 ENOG4105C3I Nad-dependent epimerase dehydratase FOC87_RS07180 ENOG4105F1A Pyruvate formate-lyase FOC87_RS07200 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC87_RS07205 ENOG4105ECP epimerase FOC87_RS07235 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC87_RS07240 ENOG4105CEN a g-specific adenine glycosylase FOC87_RS07245 ENOG4106BXE FOC87_RS07265 ENOG4105BZ1 (ABC) transporter FOC87_RS07270 ENOG4107NBY Membrane FOC87_RS07275 ENOG4105CBC glutamate synthase FOC87_RS07285 ENOG4108IUW ABC transporter FOC87_RS07305 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC87_RS07310 ENOG4105G5W regulator Fur family FOC87_RS07445 ENOG4105BZ1 (ABC) transporter FOC87_RS07460 ENOG4108JQC penicillin-binding protein 1A FOC87_RS07465 ENOG4107ZQN disulfide bond FOC87_RS07480 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC87_RS07490 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC87_RS07500 ENOG4105CYN Serine protein kinase FOC87_RS07520 ENOG4105C94 Transporter FOC87_RS07535 ENOG4105DZ6 Band 7 protein FOC87_RS07545 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC87_RS07550 ENOG4108V9W transcriptional regulatory protein FOC87_RS07555 ENOG4105D4T Citrate transporter FOC87_RS07575 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC87_RS07580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_RS07585 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC87_RS07590 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC87_RS07595 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC87_RS07600 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC87_RS07605 ENOG4108STX response regulator FOC87_RS07610 ENOG4105US7 Histidine kinase FOC87_RS07635 ENOG4108MRH transcriptional regulatory protein FOC87_RS07645 ENOG4105C6K Malic enzyme FOC87_RS07655 ENOG4108UZ3 Transporter FOC87_RS07660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS07670 ENOG4105BZU Histidine kinase FOC87_RS07675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS07680 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC87_RS07685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC87_RS07690 ENOG4108JB9 formate dehydrogenase FOC87_RS07710 ENOG4105CUB amino acid FOC87_RS07720 ENOG4105C59 p-type ATPase FOC87_RS07725 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC87_RS07760 ENOG41073R8 VanW family FOC87_RS07765 ENOG4108KGH TRANSCRIPTIONal FOC87_RS07770 ENOG4105D9N nucleoside FOC87_RS07775 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC87_RS07780 ENOG4105C37 (CBS) domain FOC87_RS07785 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_RS07790 ENOG4105DAA L-lactate FOC87_RS07805 ENOG4105DUX Transporter FOC87_RS07810 ENOG4108MES Periplasmic binding protein FOC87_RS07815 ENOG4105DQ5 transport system permease protein FOC87_RS07820 ENOG4108IHU transport system permease protein FOC87_RS07825 ENOG4105E0A ABC, transporter FOC87_RS07830 ENOG4105DMQ Methyltransferase FOC87_RS07840 ENOG4105EXW epimerase dehydratase FOC87_RS07850 ENOG4107T89 von Willebrand factor, type A FOC87_RS07855 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC87_RS07860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_RS07870 ENOG4105BZU Histidine kinase FOC87_RS07875 ENOG4105D5Q Arginine ornithine antiporter FOC87_RS07880 ENOG4107414 GntR family transcriptional regulator FOC87_RS07885 ENOG4105C5Y PTS System FOC87_RS07890 ENOG4105CG3 alpha amylase, catalytic region FOC87_RS07905 ENOG4105E1K spore germination protein FOC87_RS07910 ENOG4108XG2 Histidine kinase FOC87_RS07915 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_RS07920 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_RS07935 ENOG4105CRN Aminoglycoside phosphotransferase FOC87_RS07940 ENOG4105BZG amino acid carrier protein FOC87_RS07945 ENOG4105CDA abc transporter atp-binding protein FOC87_RS07950 ENOG4105CT1 (ABC) transporter FOC87_RS07955 ENOG4105EAD ABC transporter FOC87_RS07960 ENOG4105DRP amino acid AbC transporter FOC87_RS07965 ENOG4108IQI permease FOC87_RS07990 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC87_RS07995 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC87_RS08000 ENOG4105BZU Histidine kinase FOC87_RS08005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS08015 ENOG4105CHH sulfate transporter FOC87_RS08020 ENOG41068KF Universal stress protein FOC87_RS08030 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC87_RS08040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_RS08045 ENOG4108JQ7 (ABC) transporter FOC87_RS08055 ENOG4105CXY transporter FOC87_RS08060 ENOG41067TZ transcriptional regulator, MarR family FOC87_RS08065 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS08070 ENOG4105ETE Transcriptional regulator (LacI family FOC87_RS08075 ENOG4108RVA ribokinase FOC87_RS08090 ENOG4105CNN ABC, transporter FOC87_RS08095 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC87_RS08160 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC87_RS08165 ENOG41069ER domain protein FOC87_RS08170 ENOG4105VZ8 Transcriptional regulator FOC87_RS08175 ENOG4107D63 FOC87_RS08185 ENOG4105DUX Transporter FOC87_RS08205 ENOG4105C85 amino acid FOC87_RS08210 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_RS08225 ENOG4105MA6 gCN5-related N-acetyltransferase FOC87_RS08250 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC87_RS08255 ENOG4105E2S oxidase) subunit II FOC87_RS08270 ENOG4106CAD Protein of unknown function (DUF3311) FOC87_RS08275 ENOG4105E1V na solute symporter FOC87_RS08290 ENOG4108NHD germination protein FOC87_RS08295 ENOG4105CE1 Ferrous iron transport protein b FOC87_RS08300 ENOG4105CE1 Ferrous iron transport protein b FOC87_RS08305 ENOG4105CE1 Ferrous iron transport protein b FOC87_RS08310 ENOG4105CVA phosphate FOC87_RS08315 ENOG4105C8U phosphate abc transporter FOC87_RS08320 ENOG4105E2Z phosphate ABC transporter (Permease FOC87_RS08450 ENOG41080XQ Signal transduction protein with cbs domains FOC87_RS08470 ENOG4105ETU transcriptional activator (TenA FOC87_RS08480 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC87_RS08490 ENOG4108VEU Thiamine monophosphate synthase FOC87_RS08495 ENOG41080HI glycine oxidase FOC87_RS08510 ENOG4105D06 uba thif-type nad fad binding protein FOC87_RS08515 ENOG4105DWF phosphomethylpyrimidine kinase FOC87_RS08565 ENOG4108INS Transcriptional regulator FOC87_RS08590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_RS08600 ENOG4105C7N Xanthine uracil vitamin C permease FOC87_RS08610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC87_RS08630 ENOG4105C5Y PTS System FOC87_RS08665 ENOG4108B31 Spore germination protein FOC87_RS08685 ENOG4107Y03 Nitroreductase FOC87_RS08690 ENOG4105ED1 spovr family FOC87_RS08695 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC87_RS08700 ENOG4105XTG Pfam:DUF156 FOC87_RS08705 ENOG4105VFE sira family FOC87_RS08710 ENOG4107TPS domain protein FOC87_RS08715 ENOG4105VFE sira family FOC87_RS08720 ENOG41085GJ domain protein FOC87_RS08730 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC87_RS08735 ENOG41087NI Sulfite exporter TauE/SafE FOC87_RS08745 ENOG4108KGH TRANSCRIPTIONal FOC87_RS08770 ENOG4105EMD TRANSCRIPTIONal FOC87_RS08775 ENOG4105VCP PTS System FOC87_RS08780 ENOG4105VZJ PTS System FOC87_RS08800 ENOG41069ER domain protein FOC87_RS08805 ENOG4107RBB ABC transporter, permease FOC87_RS08810 ENOG4105C19 ABC transporter FOC87_RS08845 ENOG4105WEF catalase FOC87_RS08880 ENOG4107T5V SNARE associated Golgi FOC87_RS08915 ENOG4105CUB amino acid FOC87_RS08920 ENOG4107RWR Sodium hydrogen exchanger FOC87_RS08930 ENOG4106KNT transcriptional regulator FOC87_RS08975 ENOG4108YXU transcriptional regulator AsnC family FOC87_RS08990 ENOG4105KPY Small multidrug resistance protein FOC87_RS09005 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC87_RS09010 ENOG4105E5W Transporter FOC87_RS09020 ENOG4107RKG DJ-1/PfpI family FOC87_RS09025 ENOG4105CH6 catalase FOC87_RS09035 ENOG4105D5Q Arginine ornithine antiporter FOC87_RS09040 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC87_RS09050 ENOG4105C26 Dehydrogenase FOC87_RS09055 ENOG4105BZ1 (ABC) transporter FOC87_RS09060 ENOG4105BZ1 (ABC) transporter FOC87_RS09070 ENOG4105DRP amino acid AbC transporter FOC87_RS09075 ENOG4105CDA abc transporter atp-binding protein FOC87_RS09090 ENOG410839P FOC87_RS09125 ENOG4107FQX Alpha-acetolactate decarboxylase FOC87_RS09140 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_RS09145 ENOG4105D4P Coproporphyrinogen iii oxidase FOC87_RS09160 ENOG4105CHH sulfate transporter FOC87_RS09200 ENOG4106AKK s-layer domain-containing protein FOC87_RS09205 ENOG4106AKK s-layer domain-containing protein FOC87_RS09215 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC87_RS09225 ENOG4105CGU Enoyl-CoA hydratase FOC87_RS09245 ENOG4105DER m42 family FOC87_RS09265 ENOG4105CTU Proline racemase FOC87_RS09290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_RS09300 ENOG4108JQ7 (ABC) transporter FOC87_RS09345 ENOG4105CSH Transporter FOC87_RS09355 ENOG4108MRH transcriptional regulatory protein FOC87_RS09415 ENOG4105CDU Replicative dna helicase FOC87_RS09435 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS09495 ENOG4107P5I polyketide synthase FOC87_RS09500 ENOG4108IG5 Transcriptional regulator FOC87_RS09515 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC87_RS09545 ENOG4105CMT Dihydroxyacetone kinase FOC87_RS09555 ENOG4105CMT Dihydroxyacetone kinase FOC87_RS09560 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC87_RS09565 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC87_RS09580 ENOG410780I phosphoprotein phosphatase activity FOC87_RS09590 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC87_RS09655 ENOG4105WN5 stage II sporulation protein FOC87_RS09665 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS09675 ENOG4108MJI response regulator FOC87_RS09680 ENOG4105BZU Histidine kinase FOC87_RS09685 ENOG4105BZU Histidine kinase FOC87_RS09725 ENOG4105ENE Histidine kinase FOC87_RS09730 ENOG4108VB1 regulatoR FOC87_RS09760 ENOG4107VRP DNA repair exonuclease FOC87_RS09765 ENOG4106D4I domain protein FOC87_RS09815 ENOG4108MUZ hydrolase FOC87_RS09835 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC87_RS09850 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC87_RS09870 ENOG4105EMN RNA polymerase sigma factor FOC87_RS09895 ENOG4105C57 major facilitator superfamily FOC87_RS09900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS09910 ENOG4105EEM helicase FOC87_RS09915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_RS09940 ENOG4105K59 histidine triad (HIT) protein FOC87_RS09975 ENOG410905X membrane-flanked domain protein FOC87_RS09980 ENOG4105CKV Membrane FOC87_RS10000 ENOG41060BG Tetr family transcriptional regulator FOC87_RS10020 ENOG410905X membrane-flanked domain protein FOC87_RS10025 ENOG4105CKV Membrane FOC87_RS10030 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC87_RS10035 ENOG4105BZ4 penicillin-binding protein FOC87_RS10050 ENOG4105C1Q protoporphyrinogen oxidase FOC87_RS10080 ENOG4105NA0 Transcriptional regulator FOC87_RS10095 ENOG4105ECB domain protein FOC87_RS10100 ENOG4105ECB domain protein FOC87_RS10130 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC87_RS10140 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC87_RS10150 ENOG4106AXD FOC87_RS10155 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC87_RS10160 ENOG4105DF9 Lipoate-protein, ligase FOC87_RS10170 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_RS10235 ENOG4105ENX hydrolase FOC87_RS10240 ENOG4107RN3 metallophosphoesterase FOC87_RS10250 ENOG4107TVP HD domain protein FOC87_RS10260 ENOG4108AEY RNA polymerase sigma factor FOC87_RS10265 ENOG41086D8 Transcriptional regulator FOC87_RS10275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS10295 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC87_RS10320 ENOG4107QP3 malate synthase g FOC87_RS10350 ENOG4105XVF Competence transcription factor FOC87_RS10415 ENOG4105ERH Fumarylacetoacetate hydrolase FOC87_RS10440 ENOG4105CAQ asparagine synthetase FOC87_RS10445 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC87_RS10450 ENOG4105CH6 catalase FOC87_RS10455 ENOG4105BZU Histidine kinase FOC87_RS10475 ENOG4105QNR S1 RNA binding domain protein FOC87_RS10485 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_RS10495 ENOG4107AYK membrAne FOC87_RS10500 ENOG41073B9 FOC87_RS10510 ENOG4108KP7 hydrolase FOC87_RS10520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC87_RS10545 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_RS10550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC87_RS10565 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC87_RS10580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC87_RS10585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC87_RS10595 ENOG4108JQ7 (ABC) transporter FOC87_RS10600 ENOG4105UQX Mate efflux family protein FOC87_RS10620 ENOG4108ZCF integral membrane protein FOC87_RS10630 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_RS10640 ENOG4105DPN Oligoendopeptidase f FOC87_RS10655 ENOG4108Z18 K06886 hemoglobin FOC87_RS10660 ENOG4105MIX Adenylate cyclase FOC87_RS10680 ENOG4105EMS pseudouridine synthase FOC87_RS10700 ENOG4105K64 Glycosyl transferase, family 2 FOC87_RS10720 ENOG4107TVC Glycosyl transferase, family 2 FOC87_RS10740 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC87_RS10745 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC87_RS10755 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC87_RS10830 ENOG4105CK7 Sodium proline symporter FOC87_RS10840 ENOG4105DDQ anthranilate synthase FOC87_RS10935 ENOG4105C7S Dehydrogenase FOC87_RS10945 ENOG4105VZ8 Transcriptional regulator FOC87_RS11005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_RS11020 ENOG4108IUX (ABC) transporter FOC87_RS11025 ENOG4105RHA ABC transporter, permease FOC87_RS11070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_RS11085 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC87_RS11095 ENOG4105DZ1 carboxypeptidase FOC87_RS11100 ENOG4105VFR signal peptidase FOC87_RS11135 ENOG4105C26 Dehydrogenase FOC87_RS11145 ENOG4105F38 ABC transporter, permease FOC87_RS11150 ENOG4105D38 putrescine abc transporter FOC87_RS11155 ENOG4107RUE extracellular solute-binding protein family 1 FOC87_RS11165 ENOG4105EYF MMPL domain protein FOC87_RS11175 ENOG4108YBP pseudouridine synthase FOC87_RS11185 ENOG4105K4I Scp-like extracellular FOC87_RS11190 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC87_RS11195 ENOG4105CQB FAD linked oxidase domain protein FOC87_RS11210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS11215 ENOG4105BZU Histidine kinase FOC87_RS11220 ENOG4105JXH GntR family transcriptional regulator FOC87_RS11240 ENOG4106A3R peptidase FOC87_RS11250 ENOG4108QTI )-transporter FOC87_RS11255 ENOG4107TS3 membrane protein, TerC FOC87_RS11260 ENOG4105CZN Potassium uptake protein FOC87_RS11265 ENOG410681C small acid-soluble spore protein FOC87_RS11270 ENOG4108Z7G MaoC domain protein dehydratase FOC87_RS11290 ENOG4105CHR reductase FOC87_RS11300 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC87_RS11320 ENOG4105C4Y ABC transporter FOC87_RS11325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_RS11330 ENOG4107RCV ABC transporter, permease FOC87_RS11350 ENOG4105E98 transcriptional regulator DeoR family FOC87_RS11360 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC87_RS11370 ENOG4105PXI polysaccharide deacetylase FOC87_RS11380 ENOG4105BZU Histidine kinase FOC87_RS11385 ENOG41090MY MarR family Transcriptional regulator FOC87_RS11395 ENOG4106DF1 FOC87_RS11400 ENOG4105BZU Histidine kinase FOC87_RS11410 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC87_RS11415 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC87_RS11455 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC87_RS11460 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC87_RS11465 ENOG41079K6 HNH endonuclease FOC87_RS11475 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC87_RS11480 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS11485 ENOG4105CZV ABC transporter FOC87_RS11495 ENOG4105CJ1 ABC, transporter FOC87_RS11535 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC87_RS11540 ENOG4105EA8 2-Nitropropane dioxygenase FOC87_RS11545 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC87_RS11555 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC87_RS11580 ENOG4105NQC Flavodoxin FOC87_RS11615 ENOG4107QMU Mate efflux family protein FOC87_RS11620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC87_RS11650 ENOG4105CZN Potassium uptake protein FOC87_RS11655 ENOG41063Y9 FOC87_RS11660 ENOG4105KBJ sporulation protein ytfj FOC87_RS11685 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC87_RS11690 ENOG4105C7K acetolactate synthase FOC87_RS11695 ENOG4108ZP8 Acetolactate synthase small subunit FOC87_RS11770 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC87_RS11780 ENOG4105C5I Dehydrogenase FOC87_RS11785 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC87_RS11790 ENOG4105E0M Sulfatase FOC87_RS11800 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC87_RS11820 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC87_RS11825 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC87_RS11835 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC87_RS11840 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC87_RS11845 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC87_RS11850 ENOG4105C8J )-transporter FOC87_RS11870 ENOG4105DFD Na H antiporter FOC87_RS11890 ENOG4105ENE Histidine kinase FOC87_RS11895 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_RS11915 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC87_RS11960 ENOG4105CJ3 phosphate transporter FOC87_RS11965 ENOG4107GRR phosphate transport regulator FOC87_RS11970 ENOG4105BZ4 penicillin-binding protein FOC87_RS11985 ENOG4105BZU Histidine kinase FOC87_RS11990 ENOG4105I3N Conserved Protein FOC87_RS12005 ENOG4105BZU Histidine kinase FOC87_RS12035 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_RS12040 ENOG4105DZ1 carboxypeptidase FOC87_RS12045 ENOG4108JIC nucleoside recognition domain protein FOC87_RS12055 ENOG4105FE9 pseudouridine synthase FOC87_RS12065 ENOG4107TWT Cytochrome c biogenesis protein FOC87_RS12070 ENOG4105CRE cytochrome C FOC87_RS12075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS12080 ENOG4105BZU Histidine kinase FOC87_RS12085 ENOG4108WBT adenosyltransferase FOC87_RS12090 ENOG41063SB peptidase FOC87_RS12100 ENOG4108SAX Membrane FOC87_RS12115 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC87_RS12120 ENOG4105I7S Abortive infection protein FOC87_RS12130 ENOG4107RGJ metallophosphoesterase FOC87_RS12135 ENOG4107X2D transcriptional regulator, merr family FOC87_RS12140 ENOG4108S6Z Negative regulator of genetic competence FOC87_RS12165 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC87_RS12170 ENOG4105HDK L-asparaginase FOC87_RS12205 ENOG4105S2F FOC87_RS12210 ENOG41065D1 FOC87_RS12240 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC87_RS12255 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC87_RS12265 ENOG4105EAH synthase FOC87_RS12285 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC87_RS12290 ENOG41068YB TPR repeat-containing protein FOC87_RS12305 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC87_RS12310 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC87_RS12315 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC87_RS12345 ENOG4108JYZ YitT family FOC87_RS12350 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC87_RS12365 ENOG4105FJR Lmbe family FOC87_RS12370 ENOG4105CPK Glycosyl transferase (Group 1 FOC87_RS12405 ENOG4105DVT helicase FOC87_RS12410 ENOG4105YAC FOC87_RS12430 ENOG4105CSM endonuclease III FOC87_RS12440 ENOG4105BZ4 penicillin-binding protein FOC87_RS12500 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC87_RS12510 ENOG4105DVT helicase FOC87_RS12515 ENOG4105CTD carboxy-peptidase FOC87_RS12530 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC87_RS12540 ENOG4105C2W permease FOC87_RS12545 ENOG4105DHF Membrane FOC87_RS12550 ENOG410890F Dynamin family FOC87_RS12560 ENOG4108W0I acetyltransferase FOC87_RS12570 ENOG4105KHC sulfurtransferase FOC87_RS12595 ENOG4106032 Glutathionylspermidine synthase FOC87_RS12625 ENOG4108SZE gCN5-related N-acetyltransferase FOC87_RS12645 ENOG41081VK Ribonuclease FOC87_RS12710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_RS12720 ENOG4107RWR Sodium hydrogen exchanger FOC87_RS12725 ENOG4105CN5 Metallo-Beta-Lactamase FOC87_RS12730 ENOG4108Z5V transcriptional regulator, merr family FOC87_RS12740 ENOG4105H67 Protein of unknown function (DUF421) FOC87_RS12745 ENOG41080C8 DUF218 domain FOC87_RS12800 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC87_RS12810 ENOG4107R0U MotA TolQ exbB proton channel FOC87_RS12815 ENOG4105ER2 Ompa motb domain protein FOC87_RS12825 ENOG4105CBS Chea signal transduction histidine kinase FOC87_RS12830 ENOG4105DD5 Flagellar motor switch protein FOC87_RS12845 ENOG4105BZU Histidine kinase FOC87_RS12865 ENOG4105E1Q flagellar hook-associated protein FOC87_RS12870 ENOG4105DTJ flagellar hook-associated protein FOC87_RS12875 ENOG4107TPX flagellar hook-associated FOC87_RS12890 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC87_RS12895 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC87_RS12905 ENOG4107U2N Flagellar M-ring protein FOC87_RS12910 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC87_RS12940 ENOG4105BZE flagellar hook protein, FlgE FOC87_RS12955 ENOG4107R88 Chemotaxis protein (CheV) FOC87_RS12965 ENOG4105I03 Flagellin FOC87_RS12970 ENOG4105I03 Flagellin FOC87_RS12975 ENOG4105E4C Lytic transglycosylase catalytic FOC87_RS12985 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC87_RS12990 ENOG4105DD5 Flagellar motor switch protein FOC87_RS13000 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC87_RS13005 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC87_RS13015 ENOG4105D00 flagellar biosynthetic protein flhB FOC87_RS13020 ENOG4105D7B Flagellar biosynthesis protein flha FOC87_RS13025 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC87_RS13030 ENOG4105KTQ flagellar basal-body rod protein FOC87_RS13035 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC87_RS13060 ENOG41062JF Transcriptional regulator FOC87_RS13090 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC87_RS13120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC87_RS13130 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC87_RS13135 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC87_RS13175 ENOG4105CVJ phosphoglycerate mutase FOC87_RS13195 ENOG4105K56 Transcriptional regulator FOC87_RS13205 ENOG4105CAQ asparagine synthetase FOC87_RS13225 ENOG4105PGM cation diffusion facilitator family transporter FOC87_RS13235 ENOG4105DRR Transcriptional regulator, GntR family FOC87_RS13240 ENOG4108UZ3 Transporter FOC87_RS13245 ENOG4105CKI cobalamin synthesis protein FOC87_RS13250 ENOG4108PJD permease FOC87_RS13265 ENOG4105DFD Na H antiporter FOC87_RS13270 ENOG4105C9Q fumarate hydratase class II FOC87_RS13285 ENOG4107QJQ Mate efflux family protein FOC87_RS13290 ENOG4105EC3 peptidase S51, dipeptidase E FOC87_RS13310 ENOG4107QIV Cytochrome c biogenesis protein FOC87_RS13340 ENOG4106BRA Membrane FOC87_RS13375 ENOG4105CJ1 ABC, transporter FOC87_RS13395 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC87_RS13405 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_RS13410 ENOG4105C6K Malic enzyme FOC87_RS13445 ENOG41067QW Transcriptional regulator FOC87_RS13465 ENOG4105FVX FOC87_RS13500 ENOG4105CSR polyphosphate kinase 2 FOC87_RS13505 ENOG4105DXI Major Facilitator superfamily FOC87_RS13520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC87_RS13530 ENOG4105EU0 Major facilitator Superfamily FOC87_RS13535 ENOG4105C6T cysteine synthase FOC87_RS13555 ENOG4105C8J )-transporter FOC87_RS13565 ENOG4105X5K response regulator receiver protein FOC87_RS13570 ENOG4105H67 Protein of unknown function (DUF421) FOC87_RS13590 ENOG4106KE4 Dehydrogenase FOC87_RS13605 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC87_RS13610 ENOG4105CHR reductase FOC87_RS13615 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC87_RS13620 ENOG4105C7K acetolactate synthase FOC87_RS13630 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC87_RS13640 ENOG4105C7B Threonine dehydratase FOC87_RS13665 ENOG4105C6X Major Facilitator FOC87_RS13670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC87_RS13690 ENOG4105DY9 regulatoR FOC87_RS13695 ENOG4105CYC Transferase FOC87_RS13755 ENOG41068WN FOC87_RS13760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS13780 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC87_RS13795 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC87_RS13800 ENOG4105C0X amino acid FOC87_RS13845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS13855 ENOG4107RHR regulatoR FOC87_RS13865 ENOG4105D9N nucleoside FOC87_RS13870 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC87_RS13900 ENOG4107RAQ aminopeptidase FOC87_RS13905 ENOG4107R16 Multicopper oxidase FOC87_RS13950 ENOG4108T5E Copper resistance protein FOC87_RS13955 ENOG4105KTB nuclear export factor GLE1 FOC87_RS13960 ENOG4107RT3 EamA-like transporter family FOC87_RS13965 ENOG4105GZI Transcriptional regulator FOC87_RS13970 ENOG4108Z40 Transcriptional regulator FOC87_RS13975 ENOG4107ZXU DSBA oxidoreductase FOC87_RS13980 ENOG4108TVJ Nitroreductase FOC87_RS13985 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC87_RS13990 ENOG4106F5Q Membrane FOC87_RS14005 ENOG4105CKI cobalamin synthesis protein FOC87_RS14025 ENOG4108Z7G MaoC domain protein dehydratase FOC87_RS14030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_RS14040 ENOG4105C0Z ABC transporter FOC87_RS14045 ENOG4108IV0 ABC, transporter FOC87_RS14050 ENOG4105C32 Amino acid ABC transporter (Permease) FOC87_RS14060 ENOG4105EGI Transcriptional regulator FOC87_RS14070 ENOG4105MDS 4-oxalocrotonate tautomerase FOC87_RS14090 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC87_RS14095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC87_RS14100 ENOG4108JJ9 ABC, transporter FOC87_RS14105 ENOG4108JJ8 (ABC) transporter FOC87_RS14150 ENOG4105BZ1 (ABC) transporter FOC87_RS14155 ENOG4105EFI regulatoR FOC87_RS14160 ENOG4105EB3 Histidine kinase FOC87_RS14180 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC87_RS14205 ENOG4105D6E homoserine dehydrogenase FOC87_RS14230 ENOG4108KGH TRANSCRIPTIONal FOC87_RS14240 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS14245 ENOG4105BZU Histidine kinase FOC87_RS14260 ENOG4105KT7 mgtC SapB transporter FOC87_RS14265 ENOG4105VRR gCN5-related N-acetyltransferase FOC87_RS14275 ENOG4105DUU IucA IucC family protein FOC87_RS14280 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_RS14295 ENOG4108WBH protein TIM barrel FOC87_RS14300 ENOG4105YWU small acid-soluble spore protein FOC87_RS14310 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC87_RS14315 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS14365 ENOG4105KRN Transcriptional regulator, abrb family FOC87_RS14375 ENOG4105YVS arsR family transcriptional regulator FOC87_RS14380 ENOG4107SET aldo keto reductase FOC87_RS14385 ENOG4107XZQ multidrug resistance protein FOC87_RS14410 ENOG4105C8Q Methyl-accepting chemotaxis FOC87_RS14425 ENOG4108K88 Membrane FOC87_RS14430 ENOG4108WPJ Ferritin-like domain FOC87_RS14445 ENOG4105DEN Luciferase family FOC87_RS14465 ENOG4107QM2 Aldo Keto reductase FOC87_RS14470 ENOG4105CKI cobalamin synthesis protein FOC87_RS14490 ENOG4108IBT Inherit from COG: transposase FOC87_RS14495 ENOG4105DSE periplasmic solute binding protein FOC87_RS14505 ENOG4105K4T epimerase FOC87_RS14515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC87_RS14540 ENOG4105CVJ phosphoglycerate mutase FOC87_RS14560 ENOG4107T5V SNARE associated Golgi FOC87_RS14575 ENOG4108PJD permease FOC87_RS14585 ENOG4108S4H thioesterase Superfamily protein FOC87_RS14595 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC87_RS14615 ENOG4105SXS Protein of unknown function (DUF456) FOC87_RS14620 ENOG4105C37 (CBS) domain FOC87_RS14640 ENOG4108Z7R Chaperone CsaA FOC87_RS14660 ENOG4108ZRV stage ii sporulation protein p FOC87_RS14670 ENOG4108VXD carboxy-peptidase FOC87_RS14700 ENOG4105EFA 4-hydroxyphenylacetate FOC87_RS14710 ENOG4105U1N riboflavin FOC87_RS14725 ENOG4105KME endoribonuclease L-psp FOC87_RS14735 ENOG4105IKQ hydratase FOC87_RS14755 ENOG41069HH 4-oxalocrotonate tautomerase FOC87_RS14765 ENOG4108X4Q Hydrolase FOC87_RS14775 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC87_RS14795 ENOG41087PP glycosyltransferase MGT family FOC87_RS14800 ENOG4108JYZ YitT family FOC87_RS14805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS14835 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC87_RS14910 ENOG4105KBJ sporulation protein ytfj FOC87_RS14935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC87_RS14960 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC87_RS14970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC87_RS14975 ENOG4105EMN RNA polymerase sigma factor FOC87_RS14990 ENOG4105CNW domain protein FOC87_RS15000 ENOG4108V06 Glutathione peroxidase FOC87_RS15015 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_RS15035 ENOG4108IUE nitrate reductase beta subunit FOC87_RS15040 ENOG4105R3A Nitrate reductase FOC87_RS15050 ENOG4107V6Q Cyclic nucleotide-binding domain FOC87_RS15055 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC87_RS15060 ENOG4105D06 uba thif-type nad fad binding protein FOC87_RS15070 ENOG4108ZAF Molybdopterin FOC87_RS15090 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC87_RS15095 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC87_RS15100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC87_RS15105 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC87_RS15110 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC87_RS15115 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC87_RS15140 ENOG4105MCT stage V sporulation protein S FOC87_RS15205 ENOG4105C5H ABC transporter FOC87_RS15220 ENOG4108UUM single-stranded DNA-binding protein FOC87_RS15250 ENOG4107YX5 Pfam:DUF548 FOC87_RS15295 ENOG4105C5S asparaginyl-tRNA synthetase FOC87_RS15315 ENOG4105EC2 ftsk spoIIIe FOC87_RS15435 ENOG4105BZW Glycerate kinase FOC87_RS15440 ENOG4107QPK )-transporter FOC87_RS15445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS15450 ENOG41062D9 Histidine kinase FOC87_RS15465 ENOG4105C8J )-transporter FOC87_RS15485 ENOG4107XGZ Hydrolase FOC87_RS15490 ENOG4105CY2 Citrate transporter FOC87_RS15495 ENOG4105C0A alcohol dehydrogenase FOC87_RS15510 ENOG4105KD7 acetyltransferase FOC87_RS15515 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC87_RS15540 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC87_RS15560 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC87_RS15580 ENOG4107RVG penicillin-binding protein FOC87_RS15590 ENOG4105E9Q Acyl-transferase FOC87_RS15595 ENOG4108UT2 hemolysin iii FOC87_RS15605 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC87_RS15615 ENOG4108RCR degv family FOC87_RS15620 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC87_RS15625 ENOG4108KF3 Electron transport protein SCO1 SenC FOC87_RS15630 ENOG4107Y70 Heat shock protein FOC87_RS15635 ENOG4105CAQ asparagine synthetase FOC87_RS15655 ENOG4108MES Periplasmic binding protein FOC87_RS15660 ENOG4105F0I Aminotransferase FOC87_RS15695 ENOG4105D8X mechanosensitive ion channel FOC87_RS15700 ENOG4105BZU Histidine kinase FOC87_RS15705 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_RS15740 ENOG4105CMG Carbohydrate kinase FOC87_RS15770 ENOG4108IJ8 ABC transporter FOC87_RS15775 ENOG4105E90 ABC transporter FOC87_RS15810 ENOG4105C37 (CBS) domain FOC87_RS15835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_RS15850 ENOG4107S4Y M20 DapE family protein YgeY FOC87_RS15855 ENOG4108TSC N-acetyltransferase FOC87_RS15860 ENOG4108JUB Transcriptional regulator FOC87_RS15865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC87_RS15905 ENOG4108N23 SpoOM-related protein FOC87_RS15910 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC87_RS15920 ENOG4105SZ6 Thioredoxin FOC87_RS15980 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC87_RS16035 ENOG4105BZ4 penicillin-binding protein FOC87_RS16045 ENOG4105W8X HesB YadR YfhF-family protein FOC87_RS16055 ENOG4105DXD 2-methylcitrate dehydratase FOC87_RS16060 ENOG4105CR4 methylisocitrate lyase FOC87_RS16065 ENOG4105C1G acyl-Coa dehydrogenase FOC87_RS16070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC87_RS16080 ENOG4105N14 lysine exporter protein LysE YggA FOC87_RS16085 ENOG4105E39 Enoyl-CoA hydratase FOC87_RS16100 ENOG4107RFY SbcCD D subunit FOC87_RS16105 ENOG4105EYH Exonuclease FOC87_RS16125 ENOG4105FCD Major Facilitator FOC87_RS16130 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC87_RS16135 ENOG4105E4F Isochorismate synthase FOC87_RS16140 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC87_RS16145 ENOG4105WQI isochorismatase FOC87_RS16150 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_RS16155 ENOG4105WQT MbtH domain protein FOC87_RS16160 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS16175 ENOG4105K70 DNA-binding protein FOC87_RS16195 ENOG4105BZG amino acid carrier protein FOC87_RS16215 ENOG4105FE9 pseudouridine synthase FOC87_RS16220 ENOG4105C22 threonyL-tRNA synthetase FOC87_RS16230 ENOG4105C19 ABC transporter FOC87_RS16240 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC87_RS16265 ENOG4108D32 Methyltransferase FOC87_RS16295 ENOG41081I9 integral membrane protein FOC87_RS16310 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC87_RS16320 ENOG4105EYF MMPL domain protein FOC87_RS16345 ENOG4105WCN acetyltransferase FOC87_RS16375 ENOG4105C1Q protoporphyrinogen oxidase FOC87_RS16385 ENOG41089UC methyltransferase, type 11 FOC87_RS16390 ENOG41068WN FOC87_RS16400 ENOG4105VEQ Cold shock protein FOC87_RS16425 ENOG4107V2S Transcriptional regulator FOC87_RS16430 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC87_RS16445 ENOG4105DND Transcriptional regulator FOC87_RS16450 ENOG4108RPX mosc domain containing protein FOC87_RS16465 ENOG4105BZ1 (ABC) transporter FOC87_RS16470 ENOG4105BZ1 (ABC) transporter FOC87_RS16490 ENOG4108JCI Transcriptional regulator FOC87_RS16520 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC87_RS16530 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC87_RS16535 ENOG4108KPJ rna polymerase sigma factor FOC87_RS16560 ENOG4105F32 YngK protein FOC87_RS16585 ENOG4105RD7 BadF BadG BcrA BcrD FOC87_RS16595 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC87_RS16630 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC87_RS16645 ENOG4105C1J atp-dependent rna helicase FOC87_RS16720 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_RS16745 ENOG41088CC tellurite resistance protein tehB FOC87_RS16840 ENOG41090HR transcriptional regulator FOC87_RS16875 ENOG4105CIN aminoacyl-histidine dipeptidase FOC87_RS16885 ENOG4105EQK -acetyltransferase FOC87_RS16900 ENOG4107RVG penicillin-binding protein FOC87_RS16915 ENOG4107RF6 penicillin-binding protein FOC87_RS16920 ENOG4107RF6 penicillin-binding protein FOC87_RS16935 ENOG4105ETE Transcriptional regulator (LacI family FOC87_RS16940 ENOG4105IE8 Alpha-ketoglutarate permease FOC87_RS16945 ENOG4105CK5 oxidoreductase FOC87_RS16970 ENOG4105D2N Aldolase FOC87_RS16975 ENOG4105DH8 myo-inositol catabolism FOC87_RS17000 ENOG4105CGH 5'-nucleotidase FOC87_RS17010 ENOG4107JM4 Tetratricopeptide repeat FOC87_RS17015 ENOG4105VZ8 Transcriptional regulator FOC87_RS17030 ENOG4108VXD carboxy-peptidase FOC87_RS17045 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC87_RS17050 ENOG41067SE Tetr family transcriptional regulator FOC87_RS17055 ENOG4105C5H ABC transporter FOC87_RS17090 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC87_RS17120 ENOG4105C1G acyl-Coa dehydrogenase FOC87_RS17125 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC87_RS17130 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC87_RS17135 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC87_RS17140 ENOG4105E39 Enoyl-CoA hydratase FOC87_RS17145 ENOG4107QX3 carboxylase FOC87_RS17150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC87_RS17160 ENOG4105WCN acetyltransferase FOC87_RS17165 ENOG4105DBI uridine monophosphokinase FOC87_RS17195 ENOG4105T9C HD domain FOC87_RS17205 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC87_RS17245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_RS17245 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC87_RS17290 ENOG4105CUV Homoserine Kinase FOC87_RS17350 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC87_RS17360 ENOG4105DK7 lysyl-tRNA synthetase FOC87_RS17445 ENOG4105ETU transcriptional activator (TenA FOC87_RS17555 ENOG410667J hydrolase FOC87_RS17560 ENOG4105BZU Histidine kinase FOC87_RS17565 ENOG4107RF6 penicillin-binding protein FOC87_RS17600 ENOG4108HGU Histidine kinase FOC87_RS17610 ENOG4105RHY Pfam:UPF0157 FOC87_RS17615 ENOG4105CB2 alcohol dehydrogenase FOC87_RS17620 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC87_RS17625 ENOG4105CJN penicillin-binding protein FOC87_RS17630 ENOG4108IG5 Transcriptional regulator FOC87_RS17635 ENOG4107GJV short-chain dehydrogenase reductase FOC87_RS17645 ENOG4105FQP Beta-lactamase FOC87_RS17685 ENOG4108V4B ThiJ pfpI FOC87_RS17700 ENOG4107Y80 Major Facilitator superfamily FOC87_RS17715 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC87_RS17740 ENOG4107Y9U Membrane FOC87_RS17775 ENOG4105FCD Major Facilitator FOC87_RS17780 ENOG4105E09 nadh pyrophosphatase FOC87_RS17785 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC87_RS17790 ENOG4108Z4K mutator MutT protein FOC87_RS17810 ENOG4107TB6 phosphoglycerate mutase FOC87_RS17820 ENOG4108XI2 Domain of unknown function (DUF1963) FOC87_RS17840 ENOG4108NRW Phospholipase, patatin family FOC87_RS17845 ENOG4105KWG Pfam:DUF1696 FOC87_RS17880 ENOG4105PKS Excinuclease abc c subunit domain protein FOC87_RS17915 ENOG4107VFR oxidoreductase FOC87_RS17960 ENOG4108IUM Glycogen debranching enzyme FOC87_RS17985 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC87_RS17990 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC87_RS18000 ENOG4105FDR Membrane FOC87_RS18055 ENOG4105MSI germination protein ypeb FOC87_RS18090 ENOG4107Z3H Transcriptional regulator, TetR family FOC87_RS18125 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC87_RS18140 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC87_RS18145 ENOG4105E98 transcriptional regulator DeoR family FOC87_RS18165 ENOG41062ES Transcriptional regulator FOC87_RS18185 ENOG4107QKR Dehydrogenase FOC87_RS18195 ENOG4107RUY (E1 component), alpha subunit FOC87_RS18205 ENOG4105E1F short-chain dehydrogenase reductase FOC87_RS18210 ENOG4105RHY Pfam:UPF0157 FOC87_RS18215 ENOG4105DBI uridine monophosphokinase FOC87_RS18225 ENOG4105M6F mutator MutT protein FOC87_RS18250 ENOG4107SQ8 Glycine betaine FOC87_RS18255 ENOG4108IJ7 Glycine betaine FOC87_RS18280 ENOG4105E66 phosphoriboisomerase A FOC87_RS18285 ENOG41082BV acetyltransferase FOC87_RS18290 ENOG4108M1A Chitin-binding protein FOC87_RS18305 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_RS18310 ENOG4105MSB protein, conserved in bacteria FOC87_RS18315 ENOG4107YB6 acetyltransferase, (GNAT) family FOC87_RS18320 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC87_RS18350 ENOG4108Z7F N-acetyltransferase FOC87_RS18370 ENOG4105EEM helicase FOC87_RS18390 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC87_RS18440 ENOG4108M1A Chitin-binding protein FOC87_RS18460 ENOG4105BZG amino acid carrier protein FOC87_RS18465 ENOG4105C26 Dehydrogenase FOC87_RS18470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC87_RS18475 ENOG4105CTU Proline racemase FOC87_RS18480 ENOG4105CTU Proline racemase FOC87_RS18485 ENOG41080HI glycine oxidase FOC87_RS18495 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC87_RS18525 ENOG4107T5V SNARE associated Golgi FOC87_RS18540 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC87_RS18545 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC87_RS18560 ENOG4105DTQ mandelate racemase muconate lactonizing FOC87_RS18605 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC87_RS18610 ENOG4105BZU Histidine kinase FOC87_RS18615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS18645 ENOG4105DPN Oligoendopeptidase f FOC87_RS18650 ENOG4105DVH amino acid FOC87_RS18660 ENOG4105EPR degv family FOC87_RS18720 ENOG4106K7D Major facilitator family transporter FOC87_RS18740 ENOG4107BMA Transglycosylase associated protein FOC87_RS18755 ENOG41089UC methyltransferase, type 11 FOC87_RS18785 ENOG4105CHM Aminotransferase FOC87_RS18800 ENOG4108ZMI UPF0477 protein FOC87_RS18815 ENOG4105DVE abc transporter atp-binding protein FOC87_RS18860 ENOG4105C02 permease FOC87_RS18870 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC87_RS18875 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC87_RS18880 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC87_RS18895 ENOG4105E09 nadh pyrophosphatase FOC87_RS18915 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC87_RS18985 ENOG4108ZCF integral membrane protein FOC87_RS18990 ENOG4105E0M Sulfatase FOC87_RS18995 ENOG4105C5H ABC transporter FOC87_RS19005 ENOG4105EYF MMPL domain protein FOC87_RS19010 ENOG41082JN Transcriptional regulator FOC87_RS19030 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC87_RS19040 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC87_RS19060 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC87_RS19080 ENOG41069ER domain protein FOC87_RS19090 ENOG4105CY2 Citrate transporter FOC87_RS19095 ENOG4105E39 Enoyl-CoA hydratase FOC87_RS19100 ENOG4105J5T Amp-dependent synthetase and ligase FOC87_RS19105 ENOG4108JUB Transcriptional regulator FOC87_RS19120 ENOG4105D4B ABC, transporter FOC87_RS19125 ENOG4105F5R ABC transporter FOC87_RS19130 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC87_RS19140 ENOG4105DKT Transcriptional regulator FOC87_RS19145 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC87_RS19155 ENOG41061GT Aldolase FOC87_RS19180 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC87_RS19215 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_RS19225 ENOG4107258 Transcriptional regulator FOC87_RS19235 ENOG4105E0Y RtcB Protein FOC87_RS19240 ENOG4105ECK Fatty Acid Desaturase FOC87_RS19245 ENOG4105G6Z alkaline phosphatase FOC87_RS19255 ENOG4105VMP Transcriptional regulator FOC87_RS19270 ENOG41090T1 Membrane FOC87_RS19280 ENOG4108WCX response regulator FOC87_RS19290 ENOG41068WN FOC87_RS19315 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_RS19330 ENOG4105CSH Transporter FOC87_RS19340 ENOG4105CKK Glycosyl transferase, family 2 FOC87_RS19355 ENOG4105CKK Glycosyl transferase, family 2 FOC87_RS19365 ENOG4105C8Y Acetylornithine aminotransferase FOC87_RS19370 ENOG4105CH6 catalase FOC87_RS19410 ENOG4108TVJ Nitroreductase FOC87_RS19415 ENOG4105FS7 Transcriptional regulator FOC87_RS19450 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS19470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC87_RS19500 ENOG4108XET gCN5-related N-acetyltransferase FOC87_RS19560 ENOG410635A Membrane FOC87_RS19565 ENOG4105KNA -acetyltransferase FOC87_RS19570 ENOG4108IQI permease FOC87_RS19580 ENOG4105F1N DNA alkylation repair FOC87_RS19610 ENOG4107RF6 penicillin-binding protein FOC87_RS19645 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC87_RS19650 ENOG4107258 Transcriptional regulator FOC87_RS19660 ENOG4106N3A copper homeostasis protein cutc FOC87_RS19665 ENOG4108ZRV stage ii sporulation protein p FOC87_RS19670 ENOG4108ZHR arsR family transcriptional regulator FOC87_RS19680 ENOG4105FDT acyl-CoA dehydrogenase FOC87_RS19695 ENOG4105DWD nucleoside recognition domain protein FOC87_RS19790 ENOG4105E2A Dehydrogenase FOC87_RS19800 ENOG4108IJ0 Aspartate ammonia-lyase FOC87_RS19805 ENOG4105HDK L-asparaginase FOC87_RS19810 ENOG4108IMY Transcriptional regulator FOC87_RS19830 ENOG4108B31 Spore germination protein FOC87_RS19865 ENOG41075H3 AraC family transcriptional regulator FOC87_RS19885 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC87_RS19890 ENOG4105CUB amino acid FOC87_RS19895 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_RS19915 ENOG4105CSV Glutaminase FOC87_RS19950 ENOG4105CGH 5'-nucleotidase FOC87_RS19955 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC87_RS19995 ENOG4108606 TspO/MBR family FOC87_RS20000 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC87_RS20015 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC87_RS20020 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC87_RS20035 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC87_RS20045 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC87_RS20050 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC87_RS20060 ENOG4105C19 ABC transporter FOC87_RS20075 ENOG4108NEV two component transcriptional regulator, LytTR family FOC87_RS20080 ENOG4105DSE periplasmic solute binding protein FOC87_RS20085 ENOG4105CC5 ABC transporter FOC87_RS20090 ENOG4105DIK (ABC) transporter FOC87_RS20115 ENOG4105D6J arsenicaL-resistance protein FOC87_RS20120 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_RS20125 ENOG41085FC arsR family transcriptional regulator FOC87_RS20140 ENOG4105F7F Chaperone FOC87_RS20175 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC87_RS20180 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS20190 ENOG4105IIP Membrane FOC87_RS20205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS20210 ENOG41062D9 Histidine kinase FOC87_RS20235 ENOG4105K6H D-cysteine desulfhydrase FOC87_RS20260 ENOG4108NNI Beta-lactamase domain-containing protein FOC87_RS20265 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC87_RS20275 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC87_RS20290 ENOG4105C88 aminopeptidase FOC87_RS20300 ENOG4105W1Y Transcriptional regulator FOC87_RS20305 ENOG4105JQZ Methyltransferase FOC87_RS20325 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC87_RS20340 ENOG4105BZU Histidine kinase FOC87_RS20355 ENOG4108U05 Transcriptional regulator FOC87_RS20360 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC87_RS20370 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC87_RS20385 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC87_RS20400 ENOG4105CEP NADH dehydrogenase FOC87_RS20405 ENOG4105D4Y metalloprotease FOC87_RS20410 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_RS20460 ENOG4105TRI Hydrolase FOC87_RS20500 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_RS20525 ENOG4105C44 Serine transporter FOC87_RS20530 ENOG4105EJQ L-serine dehydratase FOC87_RS20540 ENOG4105MZU cell filamentation protein FOC87_RS20545 ENOG4108JPW Aminotransferase FOC87_RS20560 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC87_RS20570 ENOG4105DVH amino acid FOC87_RS20585 ENOG4108JQ1 Dehydrogenase FOC87_RS20605 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC87_RS20610 ENOG410874W AraC family transcriptional regulator FOC87_RS20625 ENOG4108IBT Inherit from COG: transposase FOC87_RS20640 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_RS20680 ENOG4108ISG Major Facilitator FOC87_RS20690 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC87_RS20695 ENOG4105CZM Major Facilitator FOC87_RS20710 ENOG4105DA5 (ABC) transporter FOC87_RS20715 ENOG41069JR FOC87_RS20725 ENOG4105RXJ FOC87_RS20735 ENOG4105KBX Transcriptional regulator, TetR family FOC87_RS20740 ENOG4107AUC FOC87_RS20750 ENOG4105CRW Short chain fatty acid transporter FOC87_RS20760 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC87_RS20795 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC87_RS20820 ENOG4108K8S endonuclease I FOC87_RS20825 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC87_RS20855 ENOG4105DSE periplasmic solute binding protein FOC87_RS20860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS20880 ENOG4108Z66 YbaK ebsC protein FOC87_RS20890 ENOG4105WH1 Two component transcriptional regulator luxr family FOC87_RS20910 ENOG4105KVH Transcriptional regulator FOC87_RS20915 ENOG4108RCM Nitroreductase FOC87_RS20935 ENOG4108PSK reductase FOC87_RS20945 ENOG4105CJ1 ABC, transporter FOC87_RS20980 ENOG4105D7V transposase FOC87_RS21020 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_RS21025 ENOG4105DKQ ROK family FOC87_RS21030 ENOG4106UW1 Major Facilitator superfamily FOC87_RS21035 ENOG4108UW5 maltose o-acetyltransferase FOC87_RS21060 ENOG4105DMQ Methyltransferase FOC87_RS21070 ENOG4105EV4 Multidrug resistance protein mdtH FOC87_RS21100 ENOG4105C37 (CBS) domain FOC87_RS21115 ENOG4105DDN Pentapeptide repeat-containing protein FOC87_RS21120 ENOG4105XDF Protein of unknown function (DUF1272) FOC87_RS21125 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC87_RS21130 ENOG4105CMG Carbohydrate kinase FOC87_RS21135 ENOG4105C6Z Gluconate FOC87_RS21140 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC87_RS21155 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC87_RS21175 ENOG4105C44 Serine transporter FOC87_RS21210 ENOG4108TZY GntR Family Transcriptional Regulator FOC87_RS21215 ENOG4105D9R oxidoreductase FOC87_RS21250 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC87_RS21260 ENOG4105CHR reductase FOC87_RS21270 ENOG4105KNA -acetyltransferase FOC87_RS21280 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC87_RS21285 ENOG4105KVH Transcriptional regulator FOC87_RS21350 ENOG4105KAF membrAne FOC87_RS21400 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC87_RS21415 ENOG4107YXZ hydrolase, family 25 FOC87_RS21450 ENOG4105H3G oxidoreductase FOC87_RS21495 ENOG4105K7K Transcriptional regulator FOC87_RS21500 ENOG4105CIS alcohol dehydrogenase FOC87_RS21535 ENOG4108TN2 lmbE family FOC87_RS21545 ENOG4107R3E Citrate transporter FOC87_RS21560 ENOG4108MES Periplasmic binding protein FOC87_RS21565 ENOG4105EHG Permease protein FOC87_RS21570 ENOG4105DQ5 transport system permease protein FOC87_RS21575 ENOG4105NX3 Membrane FOC87_RS21580 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC87_RS21600 ENOG4107V2S Transcriptional regulator FOC87_RS21620 ENOG4105C98 muts2 protein FOC87_RS21635 ENOG4105E5K Alpha-amylase FOC87_RS21640 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC87_RS21645 ENOG4105DPN Oligoendopeptidase f FOC87_RS21650 ENOG4108A04 Beta-lactamase FOC87_RS21680 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC87_RS21705 ENOG41082BM Transcriptional regulator, arsr family FOC87_RS21710 ENOG4105CIS alcohol dehydrogenase FOC87_RS21745 ENOG4105C09 Bile acid FOC87_RS21750 ENOG4105CQB FAD linked oxidase domain protein FOC87_RS21770 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC87_RS21780 ENOG4105K64 Glycosyl transferase, family 2 FOC87_RS21785 ENOG4105E39 Enoyl-CoA hydratase FOC87_RS21795 ENOG4105KT7 mgtC SapB transporter FOC87_RS21810 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_RS21815 ENOG41073R8 VanW family FOC87_RS21825 ENOG4108R1P FOC87_RS21840 ENOG4105VEQ Cold shock protein FOC87_RS21880 ENOG410904N short-chain dehydrogenase reductase FOC87_RS21890 ENOG4106IQC argininosuccinate lyase FOC87_RS21905 ENOG4108IA2 Sodium pantothenate symporter FOC87_RS21915 ENOG4105C26 Dehydrogenase FOC87_RS21920 ENOG4105CHR reductase FOC87_RS21930 ENOG4105EWU Squalene--hopene cyclase FOC87_RS21940 ENOG4105FR1 rard protein FOC87_RS21945 ENOG410696E Membrane FOC87_RS21960 ENOG4105D1F ATP-binding protein FOC87_RS21970 ENOG4108ZAF Molybdopterin FOC87_RS21975 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC87_RS21980 ENOG4105D06 uba thif-type nad fad binding protein FOC87_RS21985 ENOG4105TMB Formate nitrite transporter FOC87_RS21995 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC87_RS22000 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC87_RS22010 ENOG4108JB9 formate dehydrogenase FOC87_RS22015 ENOG4105E1K spore germination protein FOC87_RS22080 ENOG4107QJT sodium dicarboxylate symporter FOC87_RS22085 ENOG4108KGH TRANSCRIPTIONal FOC87_RS22095 ENOG4105EMN RNA polymerase sigma factor FOC87_RS22115 ENOG4105CIG ABC transporter FOC87_RS22125 ENOG4105D9R oxidoreductase FOC87_RS22140 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC87_RS22145 ENOG4105K4P CoA-binding domain protein FOC87_RS22150 ENOG4105C0H protease FOC87_RS22155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC87_RS22165 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC87_RS22175 ENOG4105W8X HesB YadR YfhF-family protein FOC87_RS22205 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC87_RS22210 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC87_RS22220 ENOG4108JJA ABC, transporter FOC87_RS22225 ENOG4108I0Z Aconitate hydratase FOC87_RS22265 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC87_RS22285 ENOG4107F3J Amp-dependent synthetase and ligase FOC87_RS22290 ENOG4107ZYJ bioY protein FOC87_RS22295 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_RS22345 ENOG4107AYK membrAne FOC87_RS22355 ENOG4105BZU Histidine kinase FOC87_RS22360 ENOG4105FBA Phospholipase Carboxylesterase FOC87_RS22365 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC87_RS22370 ENOG4105CK7 Sodium proline symporter FOC87_RS22375 ENOG4105CBC glutamate synthase FOC87_RS22380 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC87_RS22385 ENOG4108VJ1 Transcriptional regulator (CarD family FOC87_RS22390 ENOG4108903 Formimidoylglutamase FOC87_RS22415 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC87_RS22460 ENOG4107QIV Cytochrome c biogenesis protein FOC87_RS22480 ENOG4105CJ1 ABC, transporter FOC87_RS22490 ENOG4107RSM transcriptional regulator FOC87_RS22500 ENOG41067MG lrgb family FOC87_RS22525 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC87_RS22540 ENOG4105BZ1 (ABC) transporter FOC87_RS22545 ENOG4105BZ1 (ABC) transporter FOC87_RS22585 ENOG4105CGH 5'-nucleotidase FOC87_RS22595 ENOG4108SVB resolvase FOC87_RS22615 ENOG4105K7K Transcriptional regulator FOC87_RS22620 ENOG4105C5F glutamine synthetase FOC87_RS22625 ENOG4105KV4 Transcriptional regulator FOC87_RS22630 ENOG4105CXI aluminum resistance protein FOC87_RS22635 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC87_RS22640 ENOG4105EN6 Membrane FOC87_RS22645 ENOG4106F1P AAA ATPase, central domain protein FOC87_RS22675 ENOG41069ER domain protein FOC87_RS22680 ENOG4105DM4 PTS System FOC87_RS22685 ENOG4105DE4 1-phosphofructokinase FOC87_RS22690 ENOG4105E98 transcriptional regulator DeoR family FOC87_RS22695 ENOG4107QW4 alcohol dehydrogenase FOC87_RS22700 ENOG4108SJC Membrane FOC87_RS22710 ENOG4105C85 amino acid FOC87_RS22730 ENOG4105TMB Formate nitrite transporter FOC87_RS22735 ENOG4105K70 DNA-binding protein FOC87_RS22740 ENOG4105C59 p-type ATPase FOC87_RS22745 ENOG410681U heavy metal transport detoxification protein FOC87_RS22750 ENOG4105VPX protein, conserved in bacteria FOC87_RS22770 ENOG4105NIV Esterase FOC87_RS22775 ENOG4105E0A ABC, transporter FOC87_RS22795 ENOG4105CGK Exodeoxyribonuclease III FOC87_RS22805 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC87_RS22810 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC87_RS22840 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_RS22845 ENOG4105BZU Histidine kinase FOC87_RS22935 ENOG4105F0V Cell wall hydrolase FOC87_RS22945 ENOG4105E0M Sulfatase FOC87_RS22950 ENOG410890F Dynamin family FOC87_RS22960 ENOG4107QHE Choloylglycine hydrolase FOC87_RS22990 ENOG4105DQU oxidoreductase, subunit beta FOC87_RS22995 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC87_RS23000 ENOG4108IGT Dipeptidase FOC87_RS23005 ENOG4105MCT stage V sporulation protein S FOC87_RS23010 ENOG4105D48 metallophosphoesterase FOC87_RS23030 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC87_RS23045 ENOG4105XZV Protein of unknown function (DUF3243) FOC87_RS23050 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC87_RS23070 ENOG4105UIB (ABC) transporter FOC87_RS23075 ENOG4108JQ9 ABC transporter FOC87_RS23080 ENOG4105DIH basic membrane FOC87_RS23085 ENOG4105FDP GntR family transcriptional regulator FOC87_RS23090 ENOG4107QZI cell division protein FtsK FOC87_RS23100 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC87_RS23110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC87_RS23120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC87_RS23125 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC87_RS23130 ENOG4105E35 Dipicolinate synthase subunit A FOC87_RS23140 ENOG4105C1V Peptidase, M16 FOC87_RS23160 ENOG4105DTN riboflavin biosynthesis protein ribF FOC87_RS23175 ENOG4105W7A Protein of unknown function (DUF503) FOC87_RS23185 ENOG4105VHM ribosomal protein FOC87_RS23190 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC87_RS23195 ENOG4105CHV Transcription elongation factor NusA FOC87_RS23205 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC87_RS23210 ENOG4105EKQ RNA-directed DNA polymerase FOC87_RS23225 ENOG4105DZP Membrane-associated zinc metalloprotease FOC87_RS23235 ENOG4105KNE Phosphatidate cytidylyltransferase FOC87_RS23280 ENOG4108HE4 integrase family FOC87_RS23290 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC87_RS23295 ENOG4105C79 DNA protecting protein DprA FOC87_RS23300 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC87_RS23315 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC87_RS23340 ENOG4105VB6 UPF0109 protein FOC87_RS23360 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC87_RS23365 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC87_RS23380 ENOG4105CHR reductase FOC87_RS23385 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC87_RS23400 ENOG4105CB5 ATP-dependent DNA helicase recG FOC87_RS23405 ENOG4105DP4 dak2 domain fusion protein ylov FOC87_RS23410 ENOG4108ZAA Alkaline-shock protein FOC87_RS23425 ENOG4105FJ0 thiamine FOC87_RS23430 ENOG4105DJV ribulose-phosphate 3-epimerase FOC87_RS23435 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC87_RS23440 ENOG4105D9P serine threonine protein kinase FOC87_RS23445 ENOG4108ZF3 Phosphatase FOC87_RS23455 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC87_RS23465 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC87_RS23470 ENOG4105C25 Primosomal protein n' FOC87_RS23475 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC87_RS23495 ENOG4105DSJ YicC domain protein FOC87_RS23510 ENOG4105DC7 peptidase M24 FOC87_RS23600 ENOG4105C34 Pseudouridine synthase FOC87_RS23625 ENOG4105DBK s4 domain protein FOC87_RS23630 ENOG41067XK integral membrane protein FOC87_RS23640 ENOG4105DFA alanine racemase domain protein FOC87_RS23645 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC87_RS23650 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC87_RS23660 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS23670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC87_RS23675 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC87_RS23680 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC87_RS23685 ENOG4105D4A Cell wall formation (By similarity) FOC87_RS23695 ENOG4105CNI cell division protein FtsW FOC87_RS23710 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC87_RS23715 ENOG4105CJN penicillin-binding protein FOC87_RS23720 ENOG4105CJN penicillin-binding protein FOC87_RS23725 ENOG41068DC Essential cell division protein (By similarity) FOC87_RS23760 ENOG4105KNH Nucleic acid-binding protein FOC87_RS23770 ENOG41063PX domain protein FOC87_RS23775 ENOG4105D78 K07001 NTE family protein FOC87_RS23780 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC87_RS23790 ENOG4106H78 methyltransferase FOC87_RS23810 ENOG4107TB6 phosphoglycerate mutase FOC87_RS23825 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC87_RS23875 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC87_RS23880 ENOG4105CNI cell division protein FtsW FOC87_RS23895 ENOG4108IAB Phoh family FOC87_RS23915 ENOG4105QA2 FOC87_RS23920 ENOG4105CI3 gtp-binding protein typa FOC87_RS23930 ENOG4105ECY inositol monophosphatase FOC87_RS23950 ENOG4105CXN decarboxylase FOC87_RS24000 ENOG4105CPP Dehydrogenase, E1 component FOC87_RS24015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC87_RS24020 ENOG4108X4Q Hydrolase FOC87_RS24030 ENOG4105CN5 Metallo-Beta-Lactamase FOC87_RS24035 ENOG4107ZYR domain protein FOC87_RS24070 ENOG4108XRC Protein of unknown function (DUF458) FOC87_RS24080 ENOG4107IN1 Protein of unknown function (DUF1797) FOC87_RS24095 ENOG4105EPM Diguanylate phosphodiesterase FOC87_RS24100 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC87_RS24115 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC87_RS24125 ENOG4105UIN FOC87_RS24180 ENOG4108HGU Histidine kinase FOC87_RS24190 ENOG4105CHM Aminotransferase FOC87_RS24195 ENOG4105FKQ transcriptional regulator FOC87_RS24200 ENOG4105EG2 ABC transporter, permease FOC87_RS24210 ENOG4107FKK extracellular solute-binding protein family 1 FOC87_RS24220 ENOG4105CG3 alpha amylase, catalytic region FOC87_RS24265 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC87_RS24270 ENOG4105CHU acetyl-coa acetyltransferase FOC87_RS24300 ENOG4105K7K Transcriptional regulator FOC87_RS24305 ENOG4105DTD Dehydrogenase FOC87_RS24325 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC87_RS24365 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC87_RS24370 ENOG4105BZU Histidine kinase FOC87_RS24390 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC87_RS24405 ENOG4105CID antiterminator FOC87_RS24425 ENOG4105CE4 GlcNAc 6-P deacetylase FOC87_RS24460 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC87_RS24465 ENOG4105PTM secreted protein FOC87_RS24470 ENOG4105J7I hydrolase FOC87_RS24480 ENOG4105G6R Stage v sporulation protein ae FOC87_RS24490 ENOG4105CZ3 stage V sporulation protein ad FOC87_RS24495 ENOG41090VF Stage v sporulation protein ac FOC87_RS24515 ENOG4105C8J )-transporter FOC87_RS24520 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS24530 ENOG41082AN stage II sporulation protein FOC87_RS24535 ENOG4105DZ1 carboxypeptidase FOC87_RS24540 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS24545 ENOG4105DVE abc transporter atp-binding protein FOC87_RS24575 ENOG4105D7N magnesium and cobalt transport protein CorA FOC87_RS24600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC87_RS24610 ENOG4105I3K Ferric uptake regulator, Fur family FOC87_RS24615 ENOG4105MZ9 stage II sporulation protein m FOC87_RS24635 ENOG4105CPC Aldo Keto reductase FOC87_RS24645 ENOG4105RHY Pfam:UPF0157 FOC87_RS24665 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC87_RS24675 ENOG4105ETE Transcriptional regulator (LacI family FOC87_RS24680 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC87_RS24700 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC87_RS24705 ENOG4108R6K riboflavin synthase, subunit alpha FOC87_RS24730 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_RS24735 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC87_RS24750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC87_RS24760 ENOG4105DFD Na H antiporter FOC87_RS24765 ENOG4105CGH 5'-nucleotidase FOC87_RS24805 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC87_RS24820 ENOG4108IXY short-chain dehydrogenase reductase FOC87_RS24825 ENOG41069FQ Metallo-beta-lactamase superfamily FOC87_RS24830 ENOG4105II7 pyrroline-5-carboxylate reductase FOC87_RS24835 ENOG4105EJQ L-serine dehydratase FOC87_RS24860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_RS24870 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC87_RS24875 ENOG4105D9U N-acetyltransferase FOC87_RS24890 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC87_RS24895 ENOG4108QEG Membrane FOC87_RS24900 ENOG4105CDA abc transporter atp-binding protein FOC87_RS24905 ENOG4105E5Q amino acid AbC transporter FOC87_RS24910 ENOG4108HW3 (ABC) transporter FOC87_RS24920 ENOG4105G7B Protein of unknown function (DUF2992) FOC87_RS24925 ENOG4105E09 nadh pyrophosphatase FOC87_RS24935 ENOG4105C7S Dehydrogenase FOC87_RS24940 ENOG4105CPP Dehydrogenase, E1 component FOC87_RS24960 ENOG4107RDP Dehydrogenase FOC87_RS24970 ENOG4108JUB Transcriptional regulator FOC87_RS24980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC87_RS24995 ENOG4107QQR Sporulation FOC87_RS25000 ENOG4105S1Z Stage IV sporulation protein B FOC87_RS25005 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC87_RS25015 ENOG4105DX0 Hemolysin A FOC87_RS25025 ENOG4105CTB Polyprenyl synthetase FOC87_RS25050 ENOG4108ZSR alkaline shock protein FOC87_RS25055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC87_RS25080 ENOG410644B Stage III sporulation protein af FOC87_RS25090 ENOG4105KQ4 Stage iii sporulation protein ad FOC87_RS25095 ENOG4108CQH stage III sporulation protein AC FOC87_RS25100 ENOG4105KR5 Stage iii sporulation protein FOC87_RS25105 ENOG4105CD2 stage iii sporulation protein aa FOC87_RS25130 ENOG4105DC7 peptidase M24 FOC87_RS25145 ENOG4105CBJ Metal-dependent enzyme FOC87_RS25155 ENOG4107YBY Hydrolase FOC87_RS25170 ENOG4105K7K Transcriptional regulator FOC87_RS25185 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC87_RS25190 ENOG4105WZW rhodanese family FOC87_RS25210 ENOG41080TC multidrug resistance protein FOC87_RS25245 ENOG4105CJ1 ABC, transporter FOC87_RS25250 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC87_RS25280 ENOG4105C0D helicase FOC87_RS25400 ENOG4105C3R Methionine synthase FOC87_RS25410 ENOG4105C28 cystathionine FOC87_RS25415 ENOG4105C28 cystathionine FOC87_RS25435 ENOG4105C5X domain protein FOC87_RS25445 ENOG4105DKQ ROK family FOC87_RS25455 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC87_RS25470 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC87_RS25480 ENOG4105E2Z phosphate ABC transporter (Permease FOC87_RS25485 ENOG4105C8U phosphate abc transporter FOC87_RS25490 ENOG4105PWN phosphate abc transporter FOC87_RS25495 ENOG4107RF6 penicillin-binding protein FOC87_RS25505 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC87_RS25530 ENOG4105N80 Ferric uptake regulator, Fur family FOC87_RS25540 ENOG4105FDK ABC transporter FOC87_RS25545 ENOG4108JYZ YitT family FOC87_RS25550 ENOG41069ZM Protein of unknown function (DUF2624) FOC87_RS25575 ENOG4105EGD dinuclear metal center protein, YbgI family FOC87_RS25590 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS25595 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC87_RS25625 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC87_RS25630 ENOG4105KG3 cytidine deaminase FOC87_RS25635 ENOG4107YR5 Diacylglycerol kinase FOC87_RS25645 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC87_RS25650 ENOG4105C9A Phoh family FOC87_RS25660 ENOG41068P3 sporulation protein YqfC FOC87_RS25665 ENOG4105KTH gatB Yqey FOC87_RS25675 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC87_RS25680 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC87_RS25710 ENOG4105CSA Coproporphyrinogen iii oxidase FOC87_RS25715 ENOG4105KVH Transcriptional regulator FOC87_RS25740 ENOG4105TQK DNA polymerase iii, delta' subunit FOC87_RS25750 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC87_RS25755 ENOG4108UK2 deaminase FOC87_RS25760 ENOG4105KQC Competence protein FOC87_RS25770 ENOG4105DXX methyltransferase FOC87_RS25780 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC87_RS25790 ENOG410812S Rna-binding protein FOC87_RS25800 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC87_RS25805 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC87_RS25820 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC87_RS25850 ENOG4108TVJ Nitroreductase FOC87_RS25865 ENOG4105G6Z alkaline phosphatase FOC87_RS25875 ENOG4108MUZ hydrolase FOC87_RS25910 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC87_RS25915 ENOG4105MIR Phenylalanine 4-monooxygenase FOC87_RS25925 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC87_RS25965 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC87_RS25970 ENOG4108V5C ABC transporter FOC87_RS25980 ENOG4105C0A alcohol dehydrogenase FOC87_RS25985 ENOG4105C28 cystathionine FOC87_RS26015 ENOG4107XRG penicillin-binding protein FOC87_RS26030 ENOG4105CFP Peptidase U32 FOC87_RS26035 ENOG4105XYU peptidase (U32 family) FOC87_RS26045 ENOG4105HHA aminodeoxychorismate lyase FOC87_RS26075 ENOG4105C02 permease FOC87_RS26090 ENOG41060CR FOC87_RS26095 ENOG4105C7H Helicase, RecD TraA family FOC87_RS26110 ENOG4105C3J Cysteine desulfurase FOC87_RS26120 ENOG4105D1H recombination factor protein RarA FOC87_RS26125 ENOG4108VCI transcription factor, rsfa family FOC87_RS26130 ENOG4105CUZ uba thif-type nad fad binding protein FOC87_RS26155 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC87_RS26165 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC87_RS26170 ENOG41076HS cation diffusion facilitator family transporter FOC87_RS26175 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC87_RS26185 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC87_RS26190 ENOG4108QG2 Membrane FOC87_RS26200 ENOG4105VIE preprotein translocase, subunit YajC FOC87_RS26215 ENOG41061AI Protein of unknown function (DUF2905) FOC87_RS26230 ENOG4108HUF Transporter FOC87_RS26240 ENOG4108IPJ Membrane FOC87_RS26245 ENOG41082BM Transcriptional regulator, arsr family FOC87_RS26270 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC87_RS26275 ENOG4108IYU L-aspartate oxidase FOC87_RS26290 ENOG4108RPX mosc domain containing protein FOC87_RS26295 ENOG4105CQC Prephenate dehydratase FOC87_RS26315 ENOG4105EWM Histidine kinase FOC87_RS26340 ENOG4105X36 (ribosomal) protein FOC87_RS26350 ENOG4105C03 ribonuclease FOC87_RS26365 ENOG4107QMS site-determining protein FOC87_RS26385 ENOG4105DFF Rod shape-determining protein mreb FOC87_RS26465 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC87_RS26480 ENOG41068KH stage VI sporulation protein D FOC87_RS26490 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC87_RS26515 ENOG4105K56 Transcriptional regulator FOC87_RS26535 ENOG4108IUQ atp-dependent protease FOC87_RS26565 ENOG4108QCI YvbH-like oligomerisation region FOC87_RS26580 ENOG4105M59 Phosphodiesterase, mj0936 family FOC87_RS26595 ENOG4108XJQ germination protein FOC87_RS26605 ENOG4108PCX Major Facilitator FOC87_RS26615 ENOG4105KBX Transcriptional regulator, TetR family FOC87_RS26630 ENOG4105PFC Transcriptional regulator FOC87_RS26640 ENOG4105DZC cytosine deaminase FOC87_RS26645 ENOG41067S9 phage shock protein C, PspC FOC87_RS26650 ENOG4108JCI Transcriptional regulator FOC87_RS26660 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC87_RS26665 ENOG4108Z40 Transcriptional regulator FOC87_RS26670 ENOG4105RHA ABC transporter, permease FOC87_RS26675 ENOG4108IUX (ABC) transporter FOC87_RS26680 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC87_RS26685 ENOG4105ER2 Ompa motb domain protein FOC87_RS26690 ENOG4105E14 MotA TolQ exbB proton channel FOC87_RS26695 ENOG4108VXD carboxy-peptidase FOC87_RS26705 ENOG4105E33 succinate dehydrogenase FOC87_RS26715 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC87_RS26730 ENOG4105K63 Thioredoxin FOC87_RS26735 ENOG4105C10 Electron transfer flavoprotein FOC87_RS26740 ENOG4105BZJ Electron transfer flavoprotein FOC87_RS26745 ENOG41060WC Enoyl-CoA hydratase FOC87_RS26750 ENOG4107Z3H Transcriptional regulator, TetR family FOC87_RS26755 ENOG4105CEY Amp-dependent synthetase and ligase FOC87_RS26765 ENOG4105J76 Periplasmic binding protein FOC87_RS26770 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC87_RS26810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC87_RS26825 ENOG4105DR4 Methyltransferase FOC87_RS26840 ENOG4105KFN sortase, SrtB family FOC87_RS26845 ENOG4105E0A ABC, transporter FOC87_RS26860 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC87_RS26865 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC87_RS26875 ENOG4105FE9 pseudouridine synthase FOC87_RS26885 ENOG4105DCG PHP domain protein FOC87_RS26935 ENOG4108RWN rrna methyltransferase FOC87_RS26980 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC87_RS26985 ENOG4105CW7 secretion protein, HlyD family FOC87_RS26990 ENOG4108JGH Tetr family transcriptional regulator FOC87_RS26995 ENOG4105CN9 Peptidase m42 family protein FOC87_RS27020 ENOG4105C22 threonyL-tRNA synthetase FOC87_RS27025 ENOG4108TDW sporulation protein YtxC FOC87_RS27050 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC87_RS27135 ENOG41060SN FOC87_RS27165 ENOG4106CGH Phage Mu protein F like protein FOC87_RS27170 ENOG4108MDF Phage Portal Protein FOC87_RS27180 ENOG4108TFU terminase (Small subunit) FOC87_RS27185 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC87_RS27210 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC87_RS27285 ENOG4106CVF DNA replication protein FOC87_RS27315 ENOG4105WXW Antirepressor FOC87_RS27380 ENOG4107QJE Chromosome Partitioning Protein