locus-tag class description FOC88_RS00115 ENOG4108MDF Phage Portal Protein FOC88_RS00120 ENOG4106CGH Phage Mu protein F like protein FOC88_RS00150 ENOG41060SN FOC88_RS00230 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_RS00255 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC88_RS00275 ENOG4107QJE Chromosome Partitioning Protein FOC88_RS00355 ENOG4108IMY Transcriptional regulator FOC88_RS00405 ENOG4106CVF DNA replication protein FOC88_RS00440 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC88_RS00460 ENOG4107R8N Glycosyl transferase, family 2 FOC88_RS00485 ENOG4105E0M Sulfatase FOC88_RS00495 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC88_RS00505 ENOG4105DAA L-lactate FOC88_RS00540 ENOG4107RSM transcriptional regulator FOC88_RS00545 ENOG4105ECB domain protein FOC88_RS00550 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC88_RS00565 ENOG4105VZJ PTS System FOC88_RS00575 ENOG4105VCP PTS System FOC88_RS00580 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC88_RS00585 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC88_RS00595 ENOG4105CK1 PTS System FOC88_RS00600 ENOG4105VCP PTS System FOC88_RS00605 ENOG4105F8D glycoside hydrolase family 4 FOC88_RS00625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC88_RS00635 ENOG4105ESV Glycosyl transferase, family 4 FOC88_RS00640 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC88_RS00645 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC88_RS00650 ENOG4108KGH TRANSCRIPTIONal FOC88_RS00655 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC88_RS00665 ENOG4105KVH Transcriptional regulator FOC88_RS00680 ENOG41081UC Inherit from COG: Competence protein FOC88_RS00685 ENOG4105VEQ Cold shock protein FOC88_RS00690 ENOG4105MS2 ribosomal subunit Interface protein FOC88_RS00710 ENOG4105CAK Cell division ATP-binding protein ftsE FOC88_RS00715 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC88_RS00720 ENOG4105CN1 protease FOC88_RS00730 ENOG4105BZ1 (ABC) transporter FOC88_RS00745 ENOG4108WS4 fmn reductase FOC88_RS00755 ENOG4105DUM transcriptional regulator, lysR family FOC88_RS00760 ENOG4105HMI Membrane FOC88_RS00790 ENOG4107TXC Transcriptional regulator FOC88_RS00810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC88_RS00820 ENOG41086DT Membrane protein of unknown function FOC88_RS00840 ENOG4108S4C acetyltransferase FOC88_RS00850 ENOG4105C3M thioredoxin reductase FOC88_RS00860 ENOG4108Z4K mutator MutT protein FOC88_RS00870 ENOG4105CHW UPF0052 protein FOC88_RS00880 ENOG4105KRI phosphocarrier protein (HPr FOC88_RS00890 ENOG4105H67 Protein of unknown function (DUF421) FOC88_RS00905 ENOG4105CZ3 stage V sporulation protein ad FOC88_RS00910 ENOG41090VF Stage v sporulation protein ac FOC88_RS00930 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS00980 ENOG41067MG lrgb family FOC88_RS00985 ENOG4105XZU Preprotein translocase, subunit SecG FOC88_RS00995 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC88_RS01015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS01030 ENOG4105CM4 permease protein FOC88_RS01035 ENOG4108IPW abc transporter atp-binding protein FOC88_RS01055 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC88_RS01085 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_RS01110 ENOG4105D4A Cell wall formation (By similarity) FOC88_RS01115 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC88_RS01130 ENOG4105KVH Transcriptional regulator FOC88_RS01135 ENOG4105F27 Major Facilitator FOC88_RS01140 ENOG4105CV8 reductase FOC88_RS01160 ENOG4108RYK Nad-dependent epimerase dehydratase FOC88_RS01170 ENOG4105D9N nucleoside FOC88_RS01175 ENOG4105D9N nucleoside FOC88_RS01195 ENOG4108URH decarboxylase FOC88_RS01210 ENOG4108RMU ferritin dps family protein FOC88_RS01220 ENOG4105NCW Trka-c domain protein FOC88_RS01225 ENOG4107S91 Sodium hydrogen exchanger FOC88_RS01245 ENOG4105D4Y metalloprotease FOC88_RS01250 ENOG4105VG1 fes assembly suf system protein FOC88_RS01255 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_RS01260 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_RS01280 ENOG4105BZU Histidine kinase FOC88_RS01285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS01290 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC88_RS01300 ENOG4107ZTW SNARE associated Golgi FOC88_RS01335 ENOG4107AYK membrAne FOC88_RS01345 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC88_RS01355 ENOG4107R7I amino acid FOC88_RS01360 ENOG4108SUT Major Facilitator Superfamily FOC88_RS01380 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_RS01400 ENOG4105DZ1 carboxypeptidase FOC88_RS01415 ENOG4105CHU acetyl-coa acetyltransferase FOC88_RS01425 ENOG4105C1G acyl-Coa dehydrogenase FOC88_RS01430 ENOG4108W8B Beta-lactamase domain protein FOC88_RS01440 ENOG4108IMY Transcriptional regulator FOC88_RS01510 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC88_RS01540 ENOG4108UMI ABC transporter, permease FOC88_RS01545 ENOG4105D01 (LipO)protein FOC88_RS01550 ENOG4105D01 (LipO)protein FOC88_RS01555 ENOG4105C3K feS assembly ATPase SufC FOC88_RS01560 ENOG4105JRK feS assembly protein SufD FOC88_RS01565 ENOG4105C9B Cysteine desulfurase FOC88_RS01570 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC88_RS01575 ENOG4105DIW FeS assembly protein SUFB FOC88_RS01580 ENOG4107R8B 5'-nucleotidase FOC88_RS01585 ENOG4105KZD Domain of unknown function (DUF1805) FOC88_RS01595 ENOG4105FAA peptidase M23 FOC88_RS01620 ENOG41090T1 Membrane FOC88_RS01625 ENOG4107TXC Transcriptional regulator FOC88_RS01630 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC88_RS01635 ENOG4105MMD transcriptional regulator FOC88_RS01650 ENOG4105CBT Fructose-1,6-bisphosphatase FOC88_RS01665 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC88_RS01675 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC88_RS01685 ENOG4108W5N phosphatidylglycerophosphatase a FOC88_RS01700 ENOG41083MR nifu domain-containing protein FOC88_RS01725 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC88_RS01730 ENOG4105C4B ABC transporter, permease FOC88_RS01735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS01760 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC88_RS01770 ENOG4105EWC Purine nucleoside phosphorylase FOC88_RS01800 ENOG4105CEP NADH dehydrogenase FOC88_RS01820 ENOG41069ER domain protein FOC88_RS01840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC88_RS01860 ENOG4105KA0 thioesterase Superfamily protein FOC88_RS01880 ENOG4107R3E Citrate transporter FOC88_RS01890 ENOG4105Y38 Kinase-associated protein B FOC88_RS01905 ENOG4105C87 Aminotransferase class I and II FOC88_RS01915 ENOG4108MUZ hydrolase FOC88_RS01920 ENOG4105C5I Dehydrogenase FOC88_RS01925 ENOG4108ZB6 transcriptional regulator AsnC family FOC88_RS01930 ENOG4105CHM Aminotransferase FOC88_RS01940 ENOG4105WG9 Conserved Protein FOC88_RS01955 ENOG4107PBV potassium channel FOC88_RS01960 ENOG4105KT7 mgtC SapB transporter FOC88_RS01995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC88_RS02090 ENOG4105JVQ RNA Polymerase FOC88_RS02150 ENOG4105VEQ Cold shock protein FOC88_RS02160 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC88_RS02165 ENOG4105E4F Isochorismate synthase FOC88_RS02170 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOC88_RS02175 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC88_RS02180 ENOG4108IPT Naphthoate synthase FOC88_RS02190 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_RS02220 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC88_RS02285 ENOG41086D8 Transcriptional regulator FOC88_RS02290 ENOG4105C19 ABC transporter FOC88_RS02305 ENOG4107ZTW SNARE associated Golgi FOC88_RS02330 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC88_RS02335 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC88_RS02360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS02365 ENOG4105BZU Histidine kinase FOC88_RS02395 ENOG41087YS Phage shock protein A FOC88_RS02440 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC88_RS02445 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC88_RS02450 ENOG4108V2W Carbonate dehydratase FOC88_RS02510 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC88_RS02520 ENOG4105D2X ABC transporter substrate-binding protein FOC88_RS02535 ENOG4107T7U Sulfatase FOC88_RS02540 ENOG4107S9D Alpha beta hydrolase FOC88_RS02545 ENOG4105BZU Histidine kinase FOC88_RS02550 ENOG4105BZU Histidine kinase FOC88_RS02555 ENOG4105EGD dinuclear metal center protein, YbgI family FOC88_RS02610 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC88_RS02620 ENOG4105BZF Glycosyl transferase (Group 1 FOC88_RS02625 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC88_RS02630 ENOG4108Z0R Transferase FOC88_RS02635 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC88_RS02665 ENOG4105CIG ABC transporter FOC88_RS02675 ENOG4105N5T Radical SAM Protein FOC88_RS02695 ENOG4105C19 ABC transporter FOC88_RS02710 ENOG4105NCW Trka-c domain protein FOC88_RS02715 ENOG4107S91 Sodium hydrogen exchanger FOC88_RS02720 ENOG410605W Major Facilitator FOC88_RS02750 ENOG4108B31 Spore germination protein FOC88_RS02760 ENOG4105DWV Homoserine O-trans-acetylase FOC88_RS02770 ENOG41085GJ domain protein FOC88_RS02790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC88_RS02795 ENOG4105D06 uba thif-type nad fad binding protein FOC88_RS02805 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_RS02810 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC88_RS02815 ENOG4108ZAF Molybdopterin FOC88_RS02835 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC88_RS02840 ENOG4108VJ1 Transcriptional regulator (CarD family FOC88_RS02875 ENOG4105CBX hi0933 family FOC88_RS02890 ENOG4105YW5 deoR family transcriptional regulator FOC88_RS02895 ENOG4107QSE Dipeptidase FOC88_RS02905 ENOG4108IUM Glycogen debranching enzyme FOC88_RS02910 ENOG4108V15 phosphotransferase enzyme family FOC88_RS02925 ENOG4105C8F Beta-lactamase domain protein FOC88_RS02955 ENOG4108VDD TRNA binding domain protein FOC88_RS02985 ENOG4105K7K Transcriptional regulator FOC88_RS03015 ENOG4105C88 aminopeptidase FOC88_RS03035 ENOG4105ETE Transcriptional regulator (LacI family FOC88_RS03065 ENOG4105EP9 oxidoreductase FOC88_RS03070 ENOG4107SNB ankyrin repeat protein YahD FOC88_RS03080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS03090 ENOG4106HB6 Alpha beta hydrolase FOC88_RS03095 ENOG4105DGU Histone deacetylase FOC88_RS03100 ENOG4105W87 Cbs domain FOC88_RS03105 ENOG4105F1V Acetoin utilization protein FOC88_RS03120 ENOG4105EMN RNA polymerase sigma factor FOC88_RS03150 ENOG4105C28 cystathionine FOC88_RS03160 ENOG4105U5Y Transcriptional regulator FOC88_RS03170 ENOG4106KR7 LysR family Transcriptional regulator FOC88_RS03195 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC88_RS03205 ENOG4105EFZ amidohydrolase FOC88_RS03220 ENOG4105KBJ sporulation protein ytfj FOC88_RS03225 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC88_RS03255 ENOG4108JYZ YitT family FOC88_RS03295 ENOG4107YZX Universal stress protein FOC88_RS03315 ENOG4105VZ8 Transcriptional regulator FOC88_RS03325 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC88_RS03370 ENOG4105DC7 peptidase M24 FOC88_RS03410 ENOG4105SFS phosphoesterase RecJ domain protein FOC88_RS03420 ENOG4105VV2 FOC88_RS03425 ENOG4105C0B DNA polymerase III (alpha subunit) FOC88_RS03430 ENOG4105C6K Malic enzyme FOC88_RS03435 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS03460 ENOG4105FS0 cytoplasmic membrane protein FOC88_RS03465 ENOG4108REF Sporulation integral membrane protein ytvi FOC88_RS03475 ENOG4105BZN citrate synthase FOC88_RS03480 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC88_RS03500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS03505 ENOG4105BZU Histidine kinase FOC88_RS03510 ENOG4105C2M dna polymerase I FOC88_RS03525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC88_RS03530 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC88_RS03555 ENOG4108TDW sporulation protein YtxC FOC88_RS03560 ENOG4105C22 threonyL-tRNA synthetase FOC88_RS03585 ENOG4105CN9 Peptidase m42 family protein FOC88_RS03590 ENOG4108JGH Tetr family transcriptional regulator FOC88_RS03595 ENOG4105CW7 secretion protein, HlyD family FOC88_RS03600 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS03635 ENOG4108RWN rrna methyltransferase FOC88_RS03685 ENOG4105DCG PHP domain protein FOC88_RS03695 ENOG4105FE9 pseudouridine synthase FOC88_RS03705 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC88_RS03710 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC88_RS03725 ENOG4105E0A ABC, transporter FOC88_RS03730 ENOG4105KFN sortase, SrtB family FOC88_RS03745 ENOG4105DR4 Methyltransferase FOC88_RS03760 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS03800 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC88_RS03805 ENOG4105J76 Periplasmic binding protein FOC88_RS03815 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS03820 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_RS03825 ENOG41060WC Enoyl-CoA hydratase FOC88_RS03830 ENOG4105BZJ Electron transfer flavoprotein FOC88_RS03835 ENOG4105C10 Electron transfer flavoprotein FOC88_RS03840 ENOG4105K63 Thioredoxin FOC88_RS03855 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC88_RS03865 ENOG4105E33 succinate dehydrogenase FOC88_RS03875 ENOG4108VXD carboxy-peptidase FOC88_RS03880 ENOG4105E14 MotA TolQ exbB proton channel FOC88_RS03885 ENOG4105ER2 Ompa motb domain protein FOC88_RS03890 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC88_RS03895 ENOG4108IUX (ABC) transporter FOC88_RS03900 ENOG4105RHA ABC transporter, permease FOC88_RS03905 ENOG4108Z40 Transcriptional regulator FOC88_RS03910 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC88_RS03920 ENOG4108JCI Transcriptional regulator FOC88_RS03925 ENOG41067S9 phage shock protein C, PspC FOC88_RS03945 ENOG4105DY9 regulatoR FOC88_RS03950 ENOG4108HRK Histidine kinase FOC88_RS03955 ENOG4108JQ7 (ABC) transporter FOC88_RS03970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_RS03975 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC88_RS03980 ENOG4105DZC cytosine deaminase FOC88_RS03985 ENOG4105DZC cytosine deaminase FOC88_RS04000 ENOG4105PFC Transcriptional regulator FOC88_RS04015 ENOG4105KBX Transcriptional regulator, TetR family FOC88_RS04025 ENOG4108PCX Major Facilitator FOC88_RS04035 ENOG4108XJQ germination protein FOC88_RS04050 ENOG4105M59 Phosphodiesterase, mj0936 family FOC88_RS04070 ENOG4108QCI YvbH-like oligomerisation region FOC88_RS04100 ENOG4108IUQ atp-dependent protease FOC88_RS04120 ENOG4105K56 Transcriptional regulator FOC88_RS04145 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC88_RS04155 ENOG41068KH stage VI sporulation protein D FOC88_RS04165 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC88_RS04170 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC88_RS04190 ENOG4105DFF Rod shape-determining protein mreb FOC88_RS04210 ENOG4107QMS site-determining protein FOC88_RS04225 ENOG4105C03 ribonuclease FOC88_RS04235 ENOG4105X36 (ribosomal) protein FOC88_RS04260 ENOG4105EWM Histidine kinase FOC88_RS04280 ENOG4105CQC Prephenate dehydratase FOC88_RS04285 ENOG4108RPX mosc domain containing protein FOC88_RS04300 ENOG4108IYU L-aspartate oxidase FOC88_RS04305 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC88_RS04330 ENOG41082BM Transcriptional regulator, arsr family FOC88_RS04335 ENOG4108IPJ Membrane FOC88_RS04345 ENOG4108HUF Transporter FOC88_RS04360 ENOG41061AI Protein of unknown function (DUF2905) FOC88_RS04375 ENOG4105VIE preprotein translocase, subunit YajC FOC88_RS04385 ENOG4108QG2 Membrane FOC88_RS04390 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC88_RS04400 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC88_RS04405 ENOG41076HS cation diffusion facilitator family transporter FOC88_RS04410 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC88_RS04420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC88_RS04445 ENOG4105CUZ uba thif-type nad fad binding protein FOC88_RS04450 ENOG4108VCI transcription factor, rsfa family FOC88_RS04455 ENOG4105D1H recombination factor protein RarA FOC88_RS04465 ENOG4105C3J Cysteine desulfurase FOC88_RS04480 ENOG4105C7H Helicase, RecD TraA family FOC88_RS04485 ENOG41060CR FOC88_RS04500 ENOG4105C02 permease FOC88_RS04530 ENOG4105HHA aminodeoxychorismate lyase FOC88_RS04540 ENOG4105XYU peptidase (U32 family) FOC88_RS04545 ENOG4105CFP Peptidase U32 FOC88_RS04560 ENOG4107XRG penicillin-binding protein FOC88_RS04590 ENOG4105C28 cystathionine FOC88_RS04595 ENOG4105C0A alcohol dehydrogenase FOC88_RS04605 ENOG4108V5C ABC transporter FOC88_RS04610 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC88_RS04650 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_RS04660 ENOG4105MIR Phenylalanine 4-monooxygenase FOC88_RS04665 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC88_RS04700 ENOG4108MUZ hydrolase FOC88_RS04710 ENOG4105G6Z alkaline phosphatase FOC88_RS04725 ENOG4108TVJ Nitroreductase FOC88_RS04745 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS04760 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC88_RS04765 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC88_RS04775 ENOG410812S Rna-binding protein FOC88_RS04785 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC88_RS04795 ENOG4105DXX methyltransferase FOC88_RS04805 ENOG4105KQC Competence protein FOC88_RS04810 ENOG4108UK2 deaminase FOC88_RS04815 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC88_RS04825 ENOG4105TQK DNA polymerase iii, delta' subunit FOC88_RS04850 ENOG4105KVH Transcriptional regulator FOC88_RS04855 ENOG4105CSA Coproporphyrinogen iii oxidase FOC88_RS04885 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC88_RS04890 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC88_RS04900 ENOG4105KTH gatB Yqey FOC88_RS04905 ENOG41068P3 sporulation protein YqfC FOC88_RS04915 ENOG4105C9A Phoh family FOC88_RS04920 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC88_RS04930 ENOG4107YR5 Diacylglycerol kinase FOC88_RS04935 ENOG4105KG3 cytidine deaminase FOC88_RS04940 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC88_RS04970 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC88_RS04975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS04990 ENOG4105EGD dinuclear metal center protein, YbgI family FOC88_RS05015 ENOG41069ZM Protein of unknown function (DUF2624) FOC88_RS05020 ENOG4108JYZ YitT family FOC88_RS05025 ENOG4105FDK ABC transporter FOC88_RS05035 ENOG4105N80 Ferric uptake regulator, Fur family FOC88_RS05060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_RS05070 ENOG4107RF6 penicillin-binding protein FOC88_RS05075 ENOG4105PWN phosphate abc transporter FOC88_RS05080 ENOG4105C8U phosphate abc transporter FOC88_RS05085 ENOG4105E2Z phosphate ABC transporter (Permease FOC88_RS05095 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC88_RS05110 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC88_RS05120 ENOG4105DKQ ROK family FOC88_RS05130 ENOG4105C5X domain protein FOC88_RS05150 ENOG4105C28 cystathionine FOC88_RS05155 ENOG4105C28 cystathionine FOC88_RS05165 ENOG4105C3R Methionine synthase FOC88_RS05170 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC88_RS05285 ENOG4105C0D helicase FOC88_RS05315 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS05355 ENOG41080TC multidrug resistance protein FOC88_RS05375 ENOG4105WZW rhodanese family FOC88_RS05380 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC88_RS05415 ENOG4107YBY Hydrolase FOC88_RS05425 ENOG4105CBJ Metal-dependent enzyme FOC88_RS05440 ENOG4105DC7 peptidase M24 FOC88_RS05465 ENOG4105CD2 stage iii sporulation protein aa FOC88_RS05470 ENOG4105KR5 Stage iii sporulation protein FOC88_RS05475 ENOG4108CQH stage III sporulation protein AC FOC88_RS05480 ENOG4105KQ4 Stage iii sporulation protein ad FOC88_RS05490 ENOG410644B Stage III sporulation protein af FOC88_RS05515 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC88_RS05520 ENOG4108ZSR alkaline shock protein FOC88_RS05545 ENOG4105CTB Polyprenyl synthetase FOC88_RS05555 ENOG4105DX0 Hemolysin A FOC88_RS05565 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC88_RS05570 ENOG4105S1Z Stage IV sporulation protein B FOC88_RS05575 ENOG4107QQR Sporulation FOC88_RS05590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC88_RS05600 ENOG4108JUB Transcriptional regulator FOC88_RS05610 ENOG4107RDP Dehydrogenase FOC88_RS05630 ENOG4105CPP Dehydrogenase, E1 component FOC88_RS05635 ENOG4105C7S Dehydrogenase FOC88_RS05645 ENOG4105E09 nadh pyrophosphatase FOC88_RS05650 ENOG4105G7B Protein of unknown function (DUF2992) FOC88_RS05660 ENOG4108HW3 (ABC) transporter FOC88_RS05665 ENOG4105E5Q amino acid AbC transporter FOC88_RS05670 ENOG4105CDA abc transporter atp-binding protein FOC88_RS05675 ENOG4108QEG Membrane FOC88_RS05680 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC88_RS05695 ENOG4105D9U N-acetyltransferase FOC88_RS05700 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC88_RS05710 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_RS05735 ENOG4105EJQ L-serine dehydratase FOC88_RS05740 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_RS05745 ENOG41069FQ Metallo-beta-lactamase superfamily FOC88_RS05750 ENOG4108IXY short-chain dehydrogenase reductase FOC88_RS05765 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC88_RS05805 ENOG4105CGH 5'-nucleotidase FOC88_RS05810 ENOG4105DFD Na H antiporter FOC88_RS05820 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_RS05835 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_RS05840 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_RS05865 ENOG4108R6K riboflavin synthase, subunit alpha FOC88_RS05870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC88_RS05890 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC88_RS05895 ENOG4105ETE Transcriptional regulator (LacI family FOC88_RS05905 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC88_RS05925 ENOG4105RHY Pfam:UPF0157 FOC88_RS05935 ENOG4105CPC Aldo Keto reductase FOC88_RS05955 ENOG4105MZ9 stage II sporulation protein m FOC88_RS05960 ENOG4105I3K Ferric uptake regulator, Fur family FOC88_RS05970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC88_RS05995 ENOG4105D7N magnesium and cobalt transport protein CorA FOC88_RS06030 ENOG4105DVE abc transporter atp-binding protein FOC88_RS06035 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS06040 ENOG4105DZ1 carboxypeptidase FOC88_RS06045 ENOG41082AN stage II sporulation protein FOC88_RS06055 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS06060 ENOG4105C8J )-transporter FOC88_RS06080 ENOG41090VF Stage v sporulation protein ac FOC88_RS06085 ENOG4105CZ3 stage V sporulation protein ad FOC88_RS06095 ENOG4105G6R Stage v sporulation protein ae FOC88_RS06105 ENOG4105J7I hydrolase FOC88_RS06110 ENOG4105PTM secreted protein FOC88_RS06115 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC88_RS06150 ENOG4105CE4 GlcNAc 6-P deacetylase FOC88_RS06170 ENOG4105CID antiterminator FOC88_RS06185 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC88_RS06205 ENOG4106TD9 Diguanylate cyclase FOC88_RS06210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC88_RS06250 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC88_RS06270 ENOG4105DTD Dehydrogenase FOC88_RS06275 ENOG4105K7K Transcriptional regulator FOC88_RS06310 ENOG4105CHU acetyl-coa acetyltransferase FOC88_RS06355 ENOG4105CG3 alpha amylase, catalytic region FOC88_RS06365 ENOG4107FKK extracellular solute-binding protein family 1 FOC88_RS06375 ENOG4105EG2 ABC transporter, permease FOC88_RS06380 ENOG4105FKQ transcriptional regulator FOC88_RS06385 ENOG4105CHM Aminotransferase FOC88_RS06395 ENOG4108HGU Histidine kinase FOC88_RS06450 ENOG4105UIN FOC88_RS06460 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC88_RS06475 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC88_RS06480 ENOG4105EPM Diguanylate phosphodiesterase FOC88_RS06495 ENOG4107IN1 Protein of unknown function (DUF1797) FOC88_RS06505 ENOG4108XRC Protein of unknown function (DUF458) FOC88_RS06540 ENOG4107ZYR domain protein FOC88_RS06545 ENOG4105CN5 Metallo-Beta-Lactamase FOC88_RS06555 ENOG4108X4Q Hydrolase FOC88_RS06560 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC88_RS06575 ENOG4105CPP Dehydrogenase, E1 component FOC88_RS06625 ENOG4105CXN decarboxylase FOC88_RS06645 ENOG4105ECY inositol monophosphatase FOC88_RS06655 ENOG4105CI3 gtp-binding protein typa FOC88_RS06660 ENOG4105QA2 FOC88_RS06680 ENOG4108IAB Phoh family FOC88_RS06695 ENOG4105CNI cell division protein FtsW FOC88_RS06700 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC88_RS06750 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC88_RS06765 ENOG4107TB6 phosphoglycerate mutase FOC88_RS06785 ENOG4106H78 methyltransferase FOC88_RS06795 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC88_RS06800 ENOG4105D78 K07001 NTE family protein FOC88_RS06805 ENOG41063PX domain protein FOC88_RS06815 ENOG4105KNH Nucleic acid-binding protein FOC88_RS06850 ENOG41068DC Essential cell division protein (By similarity) FOC88_RS06855 ENOG4105CJN penicillin-binding protein FOC88_RS06860 ENOG4105CJN penicillin-binding protein FOC88_RS06865 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC88_RS06880 ENOG4105CNI cell division protein FtsW FOC88_RS06890 ENOG4105D4A Cell wall formation (By similarity) FOC88_RS06895 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC88_RS06900 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC88_RS06905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC88_RS06915 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS06925 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC88_RS06930 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC88_RS06935 ENOG4105DFA alanine racemase domain protein FOC88_RS06945 ENOG41067XK integral membrane protein FOC88_RS06950 ENOG4105DBK s4 domain protein FOC88_RS06975 ENOG4105C34 Pseudouridine synthase FOC88_RS07055 ENOG4105DC7 peptidase M24 FOC88_RS07070 ENOG4105DSJ YicC domain protein FOC88_RS07090 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC88_RS07095 ENOG4105C25 Primosomal protein n' FOC88_RS07100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC88_RS07110 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC88_RS07120 ENOG4108ZF3 Phosphatase FOC88_RS07125 ENOG4105D9P serine threonine protein kinase FOC88_RS07130 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC88_RS07135 ENOG4105DJV ribulose-phosphate 3-epimerase FOC88_RS07140 ENOG4105FJ0 thiamine FOC88_RS07155 ENOG4108ZAA Alkaline-shock protein FOC88_RS07160 ENOG4105DP4 dak2 domain fusion protein ylov FOC88_RS07165 ENOG4105CB5 ATP-dependent DNA helicase recG FOC88_RS07180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC88_RS07185 ENOG4105CHR reductase FOC88_RS07200 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC88_RS07205 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC88_RS07225 ENOG4105VB6 UPF0109 protein FOC88_RS07250 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC88_RS07265 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC88_RS07270 ENOG4105C79 DNA protecting protein DprA FOC88_RS07275 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC88_RS07285 ENOG4108HE4 integrase family FOC88_RS07330 ENOG4105KNE Phosphatidate cytidylyltransferase FOC88_RS07340 ENOG4105DZP Membrane-associated zinc metalloprotease FOC88_RS07350 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC88_RS07360 ENOG4105CHV Transcription elongation factor NusA FOC88_RS07365 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC88_RS07370 ENOG4105VHM ribosomal protein FOC88_RS07380 ENOG4105W7A Protein of unknown function (DUF503) FOC88_RS07390 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC88_RS07395 ENOG4105DTN riboflavin biosynthesis protein ribF FOC88_RS07415 ENOG4105C1V Peptidase, M16 FOC88_RS07425 ENOG4105E35 Dipicolinate synthase subunit A FOC88_RS07430 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC88_RS07435 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC88_RS07445 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC88_RS07455 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC88_RS07465 ENOG4107QZI cell division protein FtsK FOC88_RS07470 ENOG4105FDP GntR family transcriptional regulator FOC88_RS07475 ENOG4105DIH basic membrane FOC88_RS07480 ENOG4108JQ9 ABC transporter FOC88_RS07485 ENOG4105UIB (ABC) transporter FOC88_RS07505 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC88_RS07510 ENOG4105XZV Protein of unknown function (DUF3243) FOC88_RS07525 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC88_RS07550 ENOG4105D48 metallophosphoesterase FOC88_RS07555 ENOG4105MCT stage V sporulation protein S FOC88_RS07560 ENOG4108IGT Dipeptidase FOC88_RS07565 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC88_RS07570 ENOG4105DQU oxidoreductase, subunit beta FOC88_RS07600 ENOG4107QHE Choloylglycine hydrolase FOC88_RS07610 ENOG410890F Dynamin family FOC88_RS07615 ENOG4105E0M Sulfatase FOC88_RS07620 ENOG4107R6R udp-galactopyranose mutase FOC88_RS07625 ENOG4105F0V Cell wall hydrolase FOC88_RS07650 ENOG4107YEI lmbE family FOC88_RS07655 ENOG4107TTQ Alpha beta hydrolase fold FOC88_RS07670 ENOG41067MG lrgb family FOC88_RS07685 ENOG4105BZU Histidine kinase FOC88_RS07690 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_RS07720 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC88_RS07725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC88_RS07735 ENOG4105CGK Exodeoxyribonuclease III FOC88_RS07755 ENOG4105E0A ABC, transporter FOC88_RS07760 ENOG4105NIV Esterase FOC88_RS07770 ENOG4105VPX protein, conserved in bacteria FOC88_RS07775 ENOG410681U heavy metal transport detoxification protein FOC88_RS07780 ENOG4105C59 p-type ATPase FOC88_RS07790 ENOG4105K70 DNA-binding protein FOC88_RS07795 ENOG4105TMB Formate nitrite transporter FOC88_RS07815 ENOG4105C85 amino acid FOC88_RS07825 ENOG4108SJC Membrane FOC88_RS07830 ENOG4107QW4 alcohol dehydrogenase FOC88_RS07835 ENOG4105E98 transcriptional regulator DeoR family FOC88_RS07840 ENOG4105DE4 1-phosphofructokinase FOC88_RS07845 ENOG4105DM4 PTS System FOC88_RS07850 ENOG41069ER domain protein FOC88_RS07880 ENOG4106F1P AAA ATPase, central domain protein FOC88_RS07885 ENOG4105EN6 Membrane FOC88_RS07890 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC88_RS07895 ENOG4105CXI aluminum resistance protein FOC88_RS07900 ENOG4105KV4 Transcriptional regulator FOC88_RS07905 ENOG4105C5F glutamine synthetase FOC88_RS08015 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FOC88_RS08205 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_RS08245 ENOG4105K7K Transcriptional regulator FOC88_RS08265 ENOG4108SVB resolvase FOC88_RS08275 ENOG4105CGH 5'-nucleotidase FOC88_RS08285 ENOG4105D5T phosphonate abc transporter FOC88_RS08300 ENOG4105D7V transposase FOC88_RS08320 ENOG4105BZ1 (ABC) transporter FOC88_RS08325 ENOG4105BZ1 (ABC) transporter FOC88_RS08340 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_RS08365 ENOG41067MG lrgb family FOC88_RS08375 ENOG4107RSM transcriptional regulator FOC88_RS08385 ENOG4105CJ1 ABC, transporter FOC88_RS08405 ENOG4107QIV Cytochrome c biogenesis protein FOC88_RS08470 ENOG4108903 Formimidoylglutamase FOC88_RS08475 ENOG4108VJ1 Transcriptional regulator (CarD family FOC88_RS08480 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC88_RS08485 ENOG4105CBC glutamate synthase FOC88_RS08490 ENOG4105CK7 Sodium proline symporter FOC88_RS08495 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC88_RS08500 ENOG4105FBA Phospholipase Carboxylesterase FOC88_RS08505 ENOG4105BZU Histidine kinase FOC88_RS08515 ENOG4107AYK membrAne FOC88_RS08565 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS08570 ENOG4107ZYJ bioY protein FOC88_RS08575 ENOG4107F3J Amp-dependent synthetase and ligase FOC88_RS08595 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC88_RS08635 ENOG4108I0Z Aconitate hydratase FOC88_RS08640 ENOG4108JJA ABC, transporter FOC88_RS08650 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC88_RS08655 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC88_RS08685 ENOG4105W8X HesB YadR YfhF-family protein FOC88_RS08695 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC88_RS08705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS08710 ENOG4105C0H protease FOC88_RS08715 ENOG4105K4P CoA-binding domain protein FOC88_RS08720 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC88_RS08730 ENOG4105D9R oxidoreductase FOC88_RS08740 ENOG4105CIG ABC transporter FOC88_RS08760 ENOG4105EMN RNA polymerase sigma factor FOC88_RS08770 ENOG4108KGH TRANSCRIPTIONal FOC88_RS08775 ENOG4107QJT sodium dicarboxylate symporter FOC88_RS08840 ENOG4105E1K spore germination protein FOC88_RS08845 ENOG4108JB9 formate dehydrogenase FOC88_RS08855 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC88_RS08860 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC88_RS08870 ENOG4105TMB Formate nitrite transporter FOC88_RS08875 ENOG4105D06 uba thif-type nad fad binding protein FOC88_RS08880 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_RS08885 ENOG4108ZAF Molybdopterin FOC88_RS08895 ENOG4105D1F ATP-binding protein FOC88_RS08910 ENOG410696E Membrane FOC88_RS08915 ENOG4105FR1 rard protein FOC88_RS08925 ENOG4105EWU Squalene--hopene cyclase FOC88_RS08935 ENOG4105CHR reductase FOC88_RS08940 ENOG4105C26 Dehydrogenase FOC88_RS08950 ENOG4108IA2 Sodium pantothenate symporter FOC88_RS08965 ENOG4106IQC argininosuccinate lyase FOC88_RS08975 ENOG410904N short-chain dehydrogenase reductase FOC88_RS08995 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC88_RS09015 ENOG4105VEQ Cold shock protein FOC88_RS09035 ENOG4108R1P FOC88_RS09045 ENOG41073R8 VanW family FOC88_RS09050 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_RS09060 ENOG4105KT7 mgtC SapB transporter FOC88_RS09070 ENOG4105E39 Enoyl-CoA hydratase FOC88_RS09075 ENOG4105K64 Glycosyl transferase, family 2 FOC88_RS09085 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC88_RS09110 ENOG4105CQB FAD linked oxidase domain protein FOC88_RS09115 ENOG4105C09 Bile acid FOC88_RS09150 ENOG4105CIS alcohol dehydrogenase FOC88_RS09155 ENOG41082BM Transcriptional regulator, arsr family FOC88_RS09180 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC88_RS09210 ENOG4108A04 Beta-lactamase FOC88_RS09215 ENOG4105DPN Oligoendopeptidase f FOC88_RS09220 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC88_RS09225 ENOG4105E5K Alpha-amylase FOC88_RS09235 ENOG4105C98 muts2 protein FOC88_RS09255 ENOG4107V2S Transcriptional regulator FOC88_RS09265 ENOG4107CUJ Protein of unknown function (DUF2690) FOC88_RS09290 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC88_RS09295 ENOG4105NX3 Membrane FOC88_RS09300 ENOG4105DQ5 transport system permease protein FOC88_RS09305 ENOG4105EHG Permease protein FOC88_RS09310 ENOG4108MES Periplasmic binding protein FOC88_RS09325 ENOG4107R3E Citrate transporter FOC88_RS09335 ENOG4108TN2 lmbE family FOC88_RS09370 ENOG4105CIS alcohol dehydrogenase FOC88_RS09405 ENOG4105H3G oxidoreductase FOC88_RS09455 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC88_RS09480 ENOG4105KAF membrAne FOC88_RS09535 ENOG4105KVH Transcriptional regulator FOC88_RS09540 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC88_RS09555 ENOG4105CHR reductase FOC88_RS09565 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC88_RS09605 ENOG4105KVH Transcriptional regulator FOC88_RS09610 ENOG4105KVH Transcriptional regulator FOC88_RS09615 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC88_RS09620 ENOG4105D9R oxidoreductase FOC88_RS09625 ENOG4108TZY GntR Family Transcriptional Regulator FOC88_RS09665 ENOG4105C44 Serine transporter FOC88_RS09700 ENOG4105D4Y metalloprotease FOC88_RS09705 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC88_RS09720 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC88_RS09735 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC88_RS09750 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC88_RS09755 ENOG4105C6Z Gluconate FOC88_RS09760 ENOG4105CMG Carbohydrate kinase FOC88_RS09765 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC88_RS09770 ENOG4105XDF Protein of unknown function (DUF1272) FOC88_RS09775 ENOG4105DDN Pentapeptide repeat-containing protein FOC88_RS09790 ENOG4105C37 (CBS) domain FOC88_RS09820 ENOG4105EV4 Multidrug resistance protein mdtH FOC88_RS09830 ENOG4105DMQ Methyltransferase FOC88_RS09870 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC88_RS09880 ENOG4108UW5 maltose o-acetyltransferase FOC88_RS09885 ENOG4106UW1 Major Facilitator superfamily FOC88_RS09890 ENOG4105DKQ ROK family FOC88_RS09895 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_RS09955 ENOG4105CJ1 ABC, transporter FOC88_RS09965 ENOG4108PSK reductase FOC88_RS09985 ENOG4108RCM Nitroreductase FOC88_RS09990 ENOG4105KVH Transcriptional regulator FOC88_RS10005 ENOG4105CUT histidyl-tRNA synthetase FOC88_RS10010 ENOG4108Z66 YbaK ebsC protein FOC88_RS10020 ENOG41067QW Transcriptional regulator FOC88_RS10030 ENOG4108IND Tetr family transcriptional regulator FOC88_RS10035 ENOG4105EQ0 Major Facilitator superfamily FOC88_RS10070 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC88_RS10105 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC88_RS10115 ENOG4105CRW Short chain fatty acid transporter FOC88_RS10125 ENOG4105KBX Transcriptional regulator, TetR family FOC88_RS10130 ENOG4105KPY Small multidrug resistance protein FOC88_RS10135 ENOG4105RXJ FOC88_RS10145 ENOG41069JR FOC88_RS10150 ENOG4105DA5 (ABC) transporter FOC88_RS10165 ENOG4105CZM Major Facilitator FOC88_RS10170 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC88_RS10180 ENOG4108ISG Major Facilitator FOC88_RS10220 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_RS10240 ENOG410874W AraC family transcriptional regulator FOC88_RS10245 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC88_RS10265 ENOG4108JQ1 Dehydrogenase FOC88_RS10280 ENOG4105DVH amino acid FOC88_RS10290 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC88_RS10305 ENOG4108JPW Aminotransferase FOC88_RS10320 ENOG4105EJQ L-serine dehydratase FOC88_RS10325 ENOG4105C44 Serine transporter FOC88_RS10360 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_RS10395 ENOG4105TRI Hydrolase FOC88_RS10430 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_RS10440 ENOG4106P55 Transcriptional regulator FOC88_RS10450 ENOG4107QR9 Iron-sulfur cluster binding protein FOC88_RS10460 ENOG4105DJB Major Facilitator Superfamily FOC88_RS10465 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC88_RS10475 ENOG4105BZU Histidine kinase FOC88_RS10490 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC88_RS10495 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC88_RS10510 ENOG4105JQZ Methyltransferase FOC88_RS10515 ENOG4105W1Y Transcriptional regulator FOC88_RS10525 ENOG4105C88 aminopeptidase FOC88_RS10540 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_RS10550 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC88_RS10555 ENOG4108NNI Beta-lactamase domain-containing protein FOC88_RS10580 ENOG4105K6H D-cysteine desulfhydrase FOC88_RS10605 ENOG41062D9 Histidine kinase FOC88_RS10610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS10625 ENOG4105IIP Membrane FOC88_RS10635 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS10640 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC88_RS10715 ENOG4108YXU transcriptional regulator AsnC family FOC88_RS10720 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC88_RS10725 ENOG4108IG5 Transcriptional regulator FOC88_RS10730 ENOG4107P5I polyketide synthase FOC88_RS10745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS10750 ENOG4105BZU Histidine kinase FOC88_RS10770 ENOG41085FC arsR family transcriptional regulator FOC88_RS10775 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC88_RS10780 ENOG4105D6J arsenicaL-resistance protein FOC88_RS10790 ENOG4105DBI uridine monophosphokinase FOC88_RS10815 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC88_RS10820 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC88_RS10835 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC88_RS10840 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC88_RS10855 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC88_RS10860 ENOG4108606 TspO/MBR family FOC88_RS10895 ENOG41090MY MarR family Transcriptional regulator FOC88_RS10920 ENOG4105CHJ isochorismatase hydrolase FOC88_RS10930 ENOG4105CH6 catalase FOC88_RS10935 ENOG4105CGH 5'-nucleotidase FOC88_RS10970 ENOG4105CSV Glutaminase FOC88_RS10990 ENOG4108Q8B Spore germination protein FOC88_RS10995 ENOG4108NHD germination protein FOC88_RS11005 ENOG4105C6K Malic enzyme FOC88_RS11015 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_RS11025 ENOG4105CUB amino acid FOC88_RS11030 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC88_RS11035 ENOG4105YWU small acid-soluble spore protein FOC88_RS11045 ENOG41075H3 AraC family transcriptional regulator FOC88_RS11070 ENOG4105BZU Histidine kinase FOC88_RS11080 ENOG4108B31 Spore germination protein FOC88_RS11100 ENOG4108IMY Transcriptional regulator FOC88_RS11105 ENOG4105HDK L-asparaginase FOC88_RS11110 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_RS11120 ENOG4105E2A Dehydrogenase FOC88_RS11185 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC88_RS11215 ENOG4105DWD nucleoside recognition domain protein FOC88_RS11230 ENOG4105FDT acyl-CoA dehydrogenase FOC88_RS11240 ENOG4108ZHR arsR family transcriptional regulator FOC88_RS11245 ENOG4108ZRV stage ii sporulation protein p FOC88_RS11250 ENOG4106N3A copper homeostasis protein cutc FOC88_RS11260 ENOG4107258 Transcriptional regulator FOC88_RS11265 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC88_RS11305 ENOG4107RF6 penicillin-binding protein FOC88_RS11345 ENOG4105F1N DNA alkylation repair FOC88_RS11355 ENOG4108IQI permease FOC88_RS11360 ENOG4105KNA -acetyltransferase FOC88_RS11365 ENOG410635A Membrane FOC88_RS11425 ENOG4108XET gCN5-related N-acetyltransferase FOC88_RS11455 ENOG4105C19 ABC transporter FOC88_RS11465 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS11495 ENOG4105EFZ amidohydrolase FOC88_RS11500 ENOG4105D2S major facilitator superfamily FOC88_RS11505 ENOG4105G9B Transcriptional regulator FOC88_RS11515 ENOG4105VZJ PTS System FOC88_RS11530 ENOG4108QVC Component IIC FOC88_RS11535 ENOG4105VCP PTS System FOC88_RS11540 ENOG4105CS2 ec 3.2.1.21 FOC88_RS11545 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC88_RS11550 ENOG4105E39 Enoyl-CoA hydratase FOC88_RS11555 ENOG4105CHU acetyl-coa acetyltransferase FOC88_RS11560 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS11565 ENOG41082UD thioesterase Superfamily protein FOC88_RS11580 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_RS11600 ENOG4105FS7 Transcriptional regulator FOC88_RS11605 ENOG4108TVJ Nitroreductase FOC88_RS11650 ENOG4105C8Y Acetylornithine aminotransferase FOC88_RS11660 ENOG4105CKK Glycosyl transferase, family 2 FOC88_RS11675 ENOG4105CKK Glycosyl transferase, family 2 FOC88_RS11685 ENOG4105CSH Transporter FOC88_RS11700 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC88_RS11725 ENOG41068WN FOC88_RS11735 ENOG4108WCX response regulator FOC88_RS11745 ENOG41090T1 Membrane FOC88_RS11760 ENOG4105VMP Transcriptional regulator FOC88_RS11770 ENOG4105G6Z alkaline phosphatase FOC88_RS11775 ENOG4105ECK Fatty Acid Desaturase FOC88_RS11780 ENOG4105E0Y RtcB Protein FOC88_RS11790 ENOG4107258 Transcriptional regulator FOC88_RS11800 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_RS11835 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC88_RS11855 ENOG41061GT Aldolase FOC88_RS11865 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC88_RS11870 ENOG4105DKT Transcriptional regulator FOC88_RS11880 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC88_RS11885 ENOG4105F5R ABC transporter FOC88_RS11890 ENOG4105D4B ABC, transporter FOC88_RS11905 ENOG4108JUB Transcriptional regulator FOC88_RS11910 ENOG4105J5T Amp-dependent synthetase and ligase FOC88_RS11915 ENOG4105E39 Enoyl-CoA hydratase FOC88_RS11920 ENOG4105CY2 Citrate transporter FOC88_RS11930 ENOG41069ER domain protein FOC88_RS11945 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC88_RS11965 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC88_RS11975 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC88_RS11995 ENOG41082JN Transcriptional regulator FOC88_RS12000 ENOG4105EYF MMPL domain protein FOC88_RS12010 ENOG4105C5H ABC transporter FOC88_RS12015 ENOG4105E0M Sulfatase FOC88_RS12020 ENOG4108ZCF integral membrane protein FOC88_RS12040 ENOG4107VC0 DNA alkylation repair enzyme FOC88_RS12090 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC88_RS12110 ENOG4105E09 nadh pyrophosphatase FOC88_RS12135 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC88_RS12140 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC88_RS12145 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC88_RS12155 ENOG4105C02 permease FOC88_RS12195 ENOG4108ZMI UPF0477 protein FOC88_RS12210 ENOG4105CHM Aminotransferase FOC88_RS12250 ENOG41089UC methyltransferase, type 11 FOC88_RS12265 ENOG4107BMA Transglycosylase associated protein FOC88_RS12285 ENOG4106K7D Major facilitator family transporter FOC88_RS12290 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC88_RS12330 ENOG4105EPR degv family FOC88_RS12340 ENOG4105DPN Oligoendopeptidase f FOC88_RS12370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS12375 ENOG4105BZU Histidine kinase FOC88_RS12380 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC88_RS12425 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_RS12440 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC88_RS12445 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC88_RS12460 ENOG4107T5V SNARE associated Golgi FOC88_RS12490 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC88_RS12500 ENOG41080HI glycine oxidase FOC88_RS12505 ENOG4105CTU Proline racemase FOC88_RS12510 ENOG4105CTU Proline racemase FOC88_RS12515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC88_RS12520 ENOG4105C26 Dehydrogenase FOC88_RS12525 ENOG4105BZG amino acid carrier protein FOC88_RS12545 ENOG4108M1A Chitin-binding protein FOC88_RS12590 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC88_RS12610 ENOG4105EEM helicase FOC88_RS12630 ENOG4108Z7F N-acetyltransferase FOC88_RS12660 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC88_RS12685 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_RS12705 ENOG41087PP glycosyltransferase MGT family FOC88_RS12710 ENOG4108M1A Chitin-binding protein FOC88_RS12715 ENOG41082BV acetyltransferase FOC88_RS12745 ENOG4108IJ7 Glycine betaine FOC88_RS12750 ENOG4107SQ8 Glycine betaine FOC88_RS12780 ENOG4105DBI uridine monophosphokinase FOC88_RS12785 ENOG4105RHY Pfam:UPF0157 FOC88_RS12790 ENOG4105E1F short-chain dehydrogenase reductase FOC88_RS12800 ENOG4107RUY (E1 component), alpha subunit FOC88_RS12810 ENOG4107QKR Dehydrogenase FOC88_RS12835 ENOG4105E98 transcriptional regulator DeoR family FOC88_RS12855 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC88_RS12875 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_RS12910 ENOG4105MSI germination protein ypeb FOC88_RS12970 ENOG4105FDR Membrane FOC88_RS12980 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC88_RS13005 ENOG4108IUM Glycogen debranching enzyme FOC88_RS13020 ENOG4105DY8 decarboxylase FOC88_RS13060 ENOG4107VFR oxidoreductase FOC88_RS13100 ENOG4105PKS Excinuclease abc c subunit domain protein FOC88_RS13135 ENOG4105KWG Pfam:DUF1696 FOC88_RS13140 ENOG4108NRW Phospholipase, patatin family FOC88_RS13160 ENOG4108XI2 Domain of unknown function (DUF1963) FOC88_RS13185 ENOG4108Z4K mutator MutT protein FOC88_RS13190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC88_RS13195 ENOG4105E09 nadh pyrophosphatase FOC88_RS13210 ENOG4105FCD Major Facilitator FOC88_RS13245 ENOG4107Y9U Membrane FOC88_RS13265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC88_RS13280 ENOG4107Y80 Major Facilitator superfamily FOC88_RS13335 ENOG4105FQP Beta-lactamase FOC88_RS13345 ENOG4105CJN penicillin-binding protein FOC88_RS13350 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC88_RS13355 ENOG4105CB2 alcohol dehydrogenase FOC88_RS13370 ENOG4108HGU Histidine kinase FOC88_RS13385 ENOG4108JJB ABC transporter FOC88_RS13405 ENOG4107RF6 penicillin-binding protein FOC88_RS13410 ENOG4105BZU Histidine kinase FOC88_RS13415 ENOG410667J hydrolase FOC88_RS13500 ENOG4105ETU transcriptional activator (TenA FOC88_RS13595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC88_RS13610 ENOG4105CPQ Dehydrogenase FOC88_RS13655 ENOG4105CUV Homoserine Kinase FOC88_RS13670 ENOG41089UC methyltransferase, type 11 FOC88_RS13690 ENOG4108V4B ThiJ pfpI FOC88_RS13710 ENOG4105FQP Beta-lactamase FOC88_RS13725 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC88_RS13755 ENOG41075H3 AraC family transcriptional regulator FOC88_RS13780 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC88_RS13790 ENOG4105T9C HD domain FOC88_RS13820 ENOG4105DBI uridine monophosphokinase FOC88_RS13825 ENOG4105WCN acetyltransferase FOC88_RS13835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC88_RS13840 ENOG4107QX3 carboxylase FOC88_RS13845 ENOG4105E39 Enoyl-CoA hydratase FOC88_RS13850 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC88_RS13855 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC88_RS13860 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC88_RS13865 ENOG4105C1G acyl-Coa dehydrogenase FOC88_RS13880 ENOG4107Z3H Transcriptional regulator, TetR family FOC88_RS13890 ENOG4105CJ1 ABC, transporter FOC88_RS13905 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC88_RS13910 ENOG4105CEP NADH dehydrogenase FOC88_RS13930 ENOG4105BZU Histidine kinase FOC88_RS13940 ENOG4105C5H ABC transporter FOC88_RS13945 ENOG41067SE Tetr family transcriptional regulator FOC88_RS13960 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC88_RS13975 ENOG4108VXD carboxy-peptidase FOC88_RS13990 ENOG4105VZ8 Transcriptional regulator FOC88_RS14005 ENOG4105CGH 5'-nucleotidase FOC88_RS14020 ENOG4105DH8 myo-inositol catabolism FOC88_RS14025 ENOG4105D2N Aldolase FOC88_RS14050 ENOG4105CK5 oxidoreductase FOC88_RS14055 ENOG4105IE8 Alpha-ketoglutarate permease FOC88_RS14060 ENOG4105ETE Transcriptional regulator (LacI family FOC88_RS14070 ENOG4107RF6 penicillin-binding protein FOC88_RS14075 ENOG4107RF6 penicillin-binding protein FOC88_RS14100 ENOG4105CIN aminoacyl-histidine dipeptidase FOC88_RS14140 ENOG41090HR transcriptional regulator FOC88_RS14145 ENOG4107RA9 decarboxylase FOC88_RS14160 ENOG41088CC tellurite resistance protein tehB FOC88_RS14180 ENOG4108RZE Tetr family transcriptional regulator FOC88_RS14195 ENOG4105C1J atp-dependent rna helicase FOC88_RS14210 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC88_RS14245 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC88_RS14255 ENOG4105RD7 BadF BadG BcrA BcrD FOC88_RS14280 ENOG4105F32 YngK protein FOC88_RS14305 ENOG4108KPJ rna polymerase sigma factor FOC88_RS14310 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC88_RS14320 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC88_RS14350 ENOG4108JCI Transcriptional regulator FOC88_RS14370 ENOG4105BZ1 (ABC) transporter FOC88_RS14375 ENOG4105BZ1 (ABC) transporter FOC88_RS14390 ENOG4108RPX mosc domain containing protein FOC88_RS14395 ENOG4105DND Transcriptional regulator FOC88_RS14410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC88_RS14415 ENOG4107V2S Transcriptional regulator FOC88_RS14455 ENOG410667J hydrolase FOC88_RS14475 ENOG4105VEQ Cold shock protein FOC88_RS14485 ENOG41068WN FOC88_RS14490 ENOG41089UC methyltransferase, type 11 FOC88_RS14500 ENOG4105C1Q protoporphyrinogen oxidase FOC88_RS14530 ENOG4105WCN acetyltransferase FOC88_RS14555 ENOG4105EYF MMPL domain protein FOC88_RS14565 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC88_RS14580 ENOG4108Y4K DNA-binding transcriptional activator FOC88_RS14590 ENOG41081I9 integral membrane protein FOC88_RS14635 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC88_RS14645 ENOG4105C19 ABC transporter FOC88_RS14650 ENOG4105C22 threonyL-tRNA synthetase FOC88_RS14655 ENOG4105FE9 pseudouridine synthase FOC88_RS14675 ENOG4105BZG amino acid carrier protein FOC88_RS14695 ENOG4105K70 DNA-binding protein FOC88_RS14710 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS14715 ENOG4105WQT MbtH domain protein FOC88_RS14720 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS14725 ENOG4105WQI isochorismatase FOC88_RS14730 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC88_RS14735 ENOG4105E4F Isochorismate synthase FOC88_RS14740 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC88_RS14745 ENOG4105FCD Major Facilitator FOC88_RS14885 ENOG4105VTR Integrase FOC88_RS14890 ENOG4105EYH Exonuclease FOC88_RS14895 ENOG4107RFY SbcCD D subunit FOC88_RS14910 ENOG4105E39 Enoyl-CoA hydratase FOC88_RS14915 ENOG4105N14 lysine exporter protein LysE YggA FOC88_RS14925 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC88_RS14930 ENOG4105C1G acyl-Coa dehydrogenase FOC88_RS14935 ENOG4105CR4 methylisocitrate lyase FOC88_RS14940 ENOG4105DXD 2-methylcitrate dehydratase FOC88_RS14950 ENOG4105W8X HesB YadR YfhF-family protein FOC88_RS14955 ENOG4105CZM Major Facilitator FOC88_RS14960 ENOG4105BZ4 penicillin-binding protein FOC88_RS15000 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_RS15055 ENOG4105SZ6 Thioredoxin FOC88_RS15065 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC88_RS15070 ENOG4108N23 SpoOM-related protein FOC88_RS15110 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC88_RS15115 ENOG4108JUB Transcriptional regulator FOC88_RS15120 ENOG4108TSC N-acetyltransferase FOC88_RS15125 ENOG4107S4Y M20 DapE family protein YgeY FOC88_RS15140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_RS15165 ENOG4105C37 (CBS) domain FOC88_RS15200 ENOG4105E90 ABC transporter FOC88_RS15205 ENOG4108IJ8 ABC transporter FOC88_RS15275 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_RS15280 ENOG4105BZU Histidine kinase FOC88_RS15285 ENOG4105D8X mechanosensitive ion channel FOC88_RS15290 ENOG4107Y70 Heat shock protein FOC88_RS15320 ENOG4105F0I Aminotransferase FOC88_RS15325 ENOG4108MES Periplasmic binding protein FOC88_RS15340 ENOG4105CAQ asparagine synthetase FOC88_RS15345 ENOG4107Y70 Heat shock protein FOC88_RS15350 ENOG4108KF3 Electron transport protein SCO1 SenC FOC88_RS15355 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC88_RS15360 ENOG4108RCR degv family FOC88_RS15370 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC88_RS15380 ENOG4108UT2 hemolysin iii FOC88_RS15385 ENOG4105E9Q Acyl-transferase FOC88_RS15395 ENOG4107RVG penicillin-binding protein FOC88_RS15415 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC88_RS15435 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC88_RS15460 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC88_RS15465 ENOG4105KD7 acetyltransferase FOC88_RS15480 ENOG4105C0A alcohol dehydrogenase FOC88_RS15485 ENOG4105CY2 Citrate transporter FOC88_RS15490 ENOG4107XGZ Hydrolase FOC88_RS15510 ENOG4105C8J )-transporter FOC88_RS15525 ENOG41062D9 Histidine kinase FOC88_RS15530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS15535 ENOG4107QPK )-transporter FOC88_RS15540 ENOG4105BZW Glycerate kinase FOC88_RS15620 ENOG4106ANW SMI1_KNR4 FOC88_RS15625 ENOG4106BHF FOC88_RS15650 ENOG4105EC2 ftsk spoIIIe FOC88_RS15670 ENOG4105C5S asparaginyl-tRNA synthetase FOC88_RS15720 ENOG4107YX5 Pfam:DUF548 FOC88_RS15740 ENOG4108UUM single-stranded DNA-binding protein FOC88_RS15755 ENOG4105C5H ABC transporter FOC88_RS15775 ENOG4105MCT stage V sporulation protein S FOC88_RS15810 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC88_RS15815 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC88_RS15820 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC88_RS15825 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC88_RS15830 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC88_RS15835 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC88_RS15855 ENOG4108ZAF Molybdopterin FOC88_RS15860 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC88_RS15865 ENOG4105D06 uba thif-type nad fad binding protein FOC88_RS15870 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC88_RS15875 ENOG4107V6Q Cyclic nucleotide-binding domain FOC88_RS15885 ENOG4105CZV ABC transporter FOC88_RS15900 ENOG4105R3A Nitrate reductase FOC88_RS15905 ENOG4108IUE nitrate reductase beta subunit FOC88_RS15915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC88_RS15930 ENOG4108V06 Glutathione peroxidase FOC88_RS15950 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC88_RS15965 ENOG4105EMN RNA polymerase sigma factor FOC88_RS15970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC88_RS15980 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC88_RS15985 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FOC88_RS16005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC88_RS16030 ENOG4105KBJ sporulation protein ytfj FOC88_RS16055 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC88_RS16085 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS16090 ENOG4108JYZ YitT family FOC88_RS16110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC88_RS16120 ENOG4108X4Q Hydrolase FOC88_RS16145 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC88_RS16155 ENOG4108VXD carboxy-peptidase FOC88_RS16165 ENOG4108ZRV stage ii sporulation protein p FOC88_RS16185 ENOG4108Z7R Chaperone CsaA FOC88_RS16205 ENOG4105C37 (CBS) domain FOC88_RS16210 ENOG4105SXS Protein of unknown function (DUF456) FOC88_RS16230 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_RS16240 ENOG4108S4H thioesterase Superfamily protein FOC88_RS16250 ENOG4108PJD permease FOC88_RS16265 ENOG4107T5V SNARE associated Golgi FOC88_RS16285 ENOG4105CVJ phosphoglycerate mutase FOC88_RS16310 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC88_RS16320 ENOG4105K4T epimerase FOC88_RS16330 ENOG4105DSE periplasmic solute binding protein FOC88_RS16390 ENOG4105CKI cobalamin synthesis protein FOC88_RS16395 ENOG4107QM2 Aldo Keto reductase FOC88_RS16415 ENOG4105DEN Luciferase family FOC88_RS16430 ENOG4108WPJ Ferritin-like domain FOC88_RS16435 ENOG4108K88 Membrane FOC88_RS16450 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_RS16475 ENOG4107XZQ multidrug resistance protein FOC88_RS16480 ENOG4107SET aldo keto reductase FOC88_RS16485 ENOG4105YVS arsR family transcriptional regulator FOC88_RS16505 ENOG4105KRN Transcriptional regulator, abrb family FOC88_RS16555 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC88_RS16565 ENOG4105YWU small acid-soluble spore protein FOC88_RS16570 ENOG4108WBH protein TIM barrel FOC88_RS16585 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS16590 ENOG4105DUU IucA IucC family protein FOC88_RS16600 ENOG4105VRR gCN5-related N-acetyltransferase FOC88_RS16605 ENOG4105KT7 mgtC SapB transporter FOC88_RS16620 ENOG4105BZU Histidine kinase FOC88_RS16625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS16635 ENOG4108KGH TRANSCRIPTIONal FOC88_RS16660 ENOG4105D6E homoserine dehydrogenase FOC88_RS16675 ENOG4106AKJ FOC88_RS16685 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC88_RS16705 ENOG4105BZU Histidine kinase FOC88_RS16710 ENOG4105EFI regulatoR FOC88_RS16715 ENOG4105BZ1 (ABC) transporter FOC88_RS16745 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_RS16760 ENOG4108JJ8 (ABC) transporter FOC88_RS16765 ENOG4108JJ9 ABC, transporter FOC88_RS16770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC88_RS16775 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC88_RS16805 ENOG4105SKE transcriptional Regulator LysR family FOC88_RS16815 ENOG4105C32 Amino acid ABC transporter (Permease) FOC88_RS16820 ENOG4108IV0 ABC, transporter FOC88_RS16825 ENOG4105C0Z ABC transporter FOC88_RS16835 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_RS16840 ENOG4108Z7G MaoC domain protein dehydratase FOC88_RS16860 ENOG4105CKI cobalamin synthesis protein FOC88_RS16875 ENOG4106F5Q Membrane FOC88_RS16880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC88_RS16890 ENOG4108TVJ Nitroreductase FOC88_RS16895 ENOG4107ZXU DSBA oxidoreductase FOC88_RS16900 ENOG4108Z40 Transcriptional regulator FOC88_RS16905 ENOG4105GZI Transcriptional regulator FOC88_RS16910 ENOG4107RT3 EamA-like transporter family FOC88_RS16915 ENOG4105KTB nuclear export factor GLE1 FOC88_RS16920 ENOG4108T5E Copper resistance protein FOC88_RS16965 ENOG4107R16 Multicopper oxidase FOC88_RS16970 ENOG4107RAQ aminopeptidase FOC88_RS17005 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC88_RS17010 ENOG4105D9N nucleoside FOC88_RS17020 ENOG4107RHR regulatoR FOC88_RS17045 ENOG4105C0X amino acid FOC88_RS17050 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC88_RS17065 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC88_RS17085 ENOG41068WN FOC88_RS17135 ENOG4105CYC Transferase FOC88_RS17140 ENOG4105DY9 regulatoR FOC88_RS17150 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC88_RS17155 ENOG4105C6X Major Facilitator FOC88_RS17180 ENOG4105C7B Threonine dehydratase FOC88_RS17190 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC88_RS17195 ENOG4108ZP8 Acetolactate synthase small subunit FOC88_RS17200 ENOG4105C7K acetolactate synthase FOC88_RS17205 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC88_RS17210 ENOG4105CHR reductase FOC88_RS17215 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC88_RS17230 ENOG4105H67 Protein of unknown function (DUF421) FOC88_RS17235 ENOG4105X5K response regulator receiver protein FOC88_RS17245 ENOG4105C8J )-transporter FOC88_RS17265 ENOG4105C6T cysteine synthase FOC88_RS17270 ENOG4105EU0 Major facilitator Superfamily FOC88_RS17280 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC88_RS17295 ENOG4105DXI Major Facilitator superfamily FOC88_RS17305 ENOG4105U3E Transcriptional regulator FOC88_RS17310 ENOG4105CSR polyphosphate kinase 2 FOC88_RS17350 ENOG4105FVX FOC88_RS17415 ENOG4105C6K Malic enzyme FOC88_RS17420 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_RS17430 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC88_RS17450 ENOG4105CJ1 ABC, transporter FOC88_RS17485 ENOG4106BRA Membrane FOC88_RS17515 ENOG4107QIV Cytochrome c biogenesis protein FOC88_RS17535 ENOG4105EC3 peptidase S51, dipeptidase E FOC88_RS17540 ENOG4107QJQ Mate efflux family protein FOC88_RS17560 ENOG4105C9Q fumarate hydratase class II FOC88_RS17570 ENOG4105VUF Transcriptional regulator FOC88_RS17575 ENOG4105DFD Na H antiporter FOC88_RS17590 ENOG4108PJD permease FOC88_RS17595 ENOG4105CKI cobalamin synthesis protein FOC88_RS17600 ENOG4108UZ3 Transporter FOC88_RS17605 ENOG4105DRR Transcriptional regulator, GntR family FOC88_RS17615 ENOG4105PGM cation diffusion facilitator family transporter FOC88_RS17635 ENOG4105CAQ asparagine synthetase FOC88_RS17645 ENOG4105K56 Transcriptional regulator FOC88_RS17665 ENOG4105CVJ phosphoglycerate mutase FOC88_RS17705 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC88_RS17710 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC88_RS17720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS17750 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC88_RS17785 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC88_RS17790 ENOG4105KTQ flagellar basal-body rod protein FOC88_RS17795 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC88_RS17800 ENOG4105D7B Flagellar biosynthesis protein flha FOC88_RS17805 ENOG4105D00 flagellar biosynthetic protein flhB FOC88_RS17815 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC88_RS17820 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC88_RS17830 ENOG4105DD5 Flagellar motor switch protein FOC88_RS17835 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC88_RS17845 ENOG4105E4C Lytic transglycosylase catalytic FOC88_RS17850 ENOG4105I03 Flagellin FOC88_RS17870 ENOG4107R88 Chemotaxis protein (CheV) FOC88_RS17885 ENOG4105BZE flagellar hook protein, FlgE FOC88_RS17915 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC88_RS17930 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC88_RS17935 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC88_RS17950 ENOG4107TPX flagellar hook-associated FOC88_RS17955 ENOG4105DTJ flagellar hook-associated protein FOC88_RS17960 ENOG4105E1Q flagellar hook-associated protein FOC88_RS17980 ENOG4105BZU Histidine kinase FOC88_RS17995 ENOG4105DD5 Flagellar motor switch protein FOC88_RS18000 ENOG4105CBS Chea signal transduction histidine kinase FOC88_RS18005 ENOG4107YTP response regulator receiver protein FOC88_RS18010 ENOG4105ER2 Ompa motb domain protein FOC88_RS18015 ENOG4107R0U MotA TolQ exbB proton channel FOC88_RS18025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC88_RS18080 ENOG41080C8 DUF218 domain FOC88_RS18085 ENOG4105H67 Protein of unknown function (DUF421) FOC88_RS18095 ENOG4108Z5V transcriptional regulator, merr family FOC88_RS18100 ENOG4105CN5 Metallo-Beta-Lactamase FOC88_RS18105 ENOG4107RWR Sodium hydrogen exchanger FOC88_RS18115 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC88_RS18180 ENOG41081VK Ribonuclease FOC88_RS18200 ENOG4108SZE gCN5-related N-acetyltransferase FOC88_RS18215 ENOG4105CPK Glycosyl transferase (Group 1 FOC88_RS18275 ENOG4106032 Glutathionylspermidine synthase FOC88_RS18300 ENOG4105KHC sulfurtransferase FOC88_RS18310 ENOG4108W0I acetyltransferase FOC88_RS18320 ENOG410890F Dynamin family FOC88_RS18325 ENOG4105DHF Membrane FOC88_RS18330 ENOG4105C2W permease FOC88_RS18340 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_RS18355 ENOG4105CTD carboxy-peptidase FOC88_RS18360 ENOG4105DVT helicase FOC88_RS18370 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC88_RS18430 ENOG4105BZ4 penicillin-binding protein FOC88_RS18440 ENOG4105CSM endonuclease III FOC88_RS18460 ENOG4105YAC FOC88_RS18465 ENOG4105DVT helicase FOC88_RS18500 ENOG4105CPK Glycosyl transferase (Group 1 FOC88_RS18505 ENOG4105FJR Lmbe family FOC88_RS18520 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC88_RS18525 ENOG4108JYZ YitT family FOC88_RS18555 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC88_RS18560 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC88_RS18565 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC88_RS18580 ENOG41068YB TPR repeat-containing protein FOC88_RS18585 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC88_RS18605 ENOG4105EAH synthase FOC88_RS18615 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC88_RS18630 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC88_RS18660 ENOG41065D1 FOC88_RS18665 ENOG4105S2F FOC88_RS18700 ENOG4105HDK L-asparaginase FOC88_RS18705 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC88_RS18730 ENOG4108S6Z Negative regulator of genetic competence FOC88_RS18735 ENOG4107X2D transcriptional regulator, merr family FOC88_RS18740 ENOG4107RGJ metallophosphoesterase FOC88_RS18750 ENOG4105I7S Abortive infection protein FOC88_RS18755 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC88_RS18770 ENOG4108SAX Membrane FOC88_RS18780 ENOG41063SB peptidase FOC88_RS18785 ENOG4108WBT adenosyltransferase FOC88_RS18790 ENOG4105BZU Histidine kinase FOC88_RS18795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS18800 ENOG4105CRE cytochrome C FOC88_RS18805 ENOG4107TWT Cytochrome c biogenesis protein FOC88_RS18815 ENOG4105FE9 pseudouridine synthase FOC88_RS18825 ENOG4108JIC nucleoside recognition domain protein FOC88_RS18830 ENOG4105DZ1 carboxypeptidase FOC88_RS18835 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_RS18870 ENOG4105BZU Histidine kinase FOC88_RS18885 ENOG4105I3N Conserved Protein FOC88_RS18890 ENOG4105BZU Histidine kinase FOC88_RS18905 ENOG4105BZ4 penicillin-binding protein FOC88_RS18910 ENOG4107GRR phosphate transport regulator FOC88_RS18915 ENOG4105CJ3 phosphate transporter FOC88_RS18960 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC88_RS18980 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_RS18985 ENOG4105ENE Histidine kinase FOC88_RS19005 ENOG4105DFD Na H antiporter FOC88_RS19025 ENOG4105C8J )-transporter FOC88_RS19030 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC88_RS19035 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC88_RS19040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC88_RS19050 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC88_RS19055 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC88_RS19075 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC88_RS19085 ENOG4105E0M Sulfatase FOC88_RS19090 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC88_RS19105 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC88_RS19180 ENOG4108ZP8 Acetolactate synthase small subunit FOC88_RS19185 ENOG4105C7K acetolactate synthase FOC88_RS19190 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC88_RS19210 ENOG4105KBJ sporulation protein ytfj FOC88_RS19215 ENOG41063Y9 FOC88_RS19220 ENOG4105CZN Potassium uptake protein FOC88_RS19250 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC88_RS19255 ENOG4107QMU Mate efflux family protein FOC88_RS19290 ENOG4105NQC Flavodoxin FOC88_RS19315 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC88_RS19325 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC88_RS19330 ENOG4105EA8 2-Nitropropane dioxygenase FOC88_RS19335 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC88_RS19375 ENOG4105CJ1 ABC, transporter FOC88_RS19385 ENOG4105CZV ABC transporter FOC88_RS19390 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS19395 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC88_RS19415 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC88_RS19455 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC88_RS19460 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC88_RS19470 ENOG4105BZU Histidine kinase FOC88_RS19475 ENOG4106DF1 FOC88_RS19485 ENOG41090MY MarR family Transcriptional regulator FOC88_RS19490 ENOG4105BZU Histidine kinase FOC88_RS19500 ENOG4105PXI polysaccharide deacetylase FOC88_RS19510 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC88_RS19520 ENOG4105E98 transcriptional regulator DeoR family FOC88_RS19540 ENOG4107RCV ABC transporter, permease FOC88_RS19545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS19550 ENOG4105C4Y ABC transporter FOC88_RS19570 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC88_RS19580 ENOG4105CHR reductase FOC88_RS19600 ENOG4108Z7G MaoC domain protein dehydratase FOC88_RS19605 ENOG410681C small acid-soluble spore protein FOC88_RS19610 ENOG4105CZN Potassium uptake protein FOC88_RS19615 ENOG4107TS3 membrane protein, TerC FOC88_RS19620 ENOG4108QTI )-transporter FOC88_RS19630 ENOG4106A3R peptidase FOC88_RS19650 ENOG4105JXH GntR family transcriptional regulator FOC88_RS19655 ENOG4105BZU Histidine kinase FOC88_RS19660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS19675 ENOG4105CQB FAD linked oxidase domain protein FOC88_RS19680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC88_RS19685 ENOG4105K4I Scp-like extracellular FOC88_RS19695 ENOG4108YBP pseudouridine synthase FOC88_RS19705 ENOG4105EYF MMPL domain protein FOC88_RS19715 ENOG4107RUE extracellular solute-binding protein family 1 FOC88_RS19720 ENOG4105D38 putrescine abc transporter FOC88_RS19725 ENOG4105F38 ABC transporter, permease FOC88_RS19735 ENOG4105C26 Dehydrogenase FOC88_RS19770 ENOG4105VFR signal peptidase FOC88_RS19775 ENOG4105DZ1 carboxypeptidase FOC88_RS19785 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC88_RS19845 ENOG4105VZ8 Transcriptional regulator FOC88_RS19855 ENOG4105C7S Dehydrogenase FOC88_RS19945 ENOG4105DDQ anthranilate synthase FOC88_RS19955 ENOG4105CK7 Sodium proline symporter FOC88_RS20030 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC88_RS20040 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC88_RS20045 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC88_RS20065 ENOG4107TVC Glycosyl transferase, family 2 FOC88_RS20085 ENOG4105K64 Glycosyl transferase, family 2 FOC88_RS20105 ENOG4105EMS pseudouridine synthase FOC88_RS20125 ENOG4105MIX Adenylate cyclase FOC88_RS20130 ENOG4108Z18 K06886 hemoglobin FOC88_RS20145 ENOG4105DPN Oligoendopeptidase f FOC88_RS20155 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_RS20165 ENOG4108ZCF integral membrane protein FOC88_RS20185 ENOG4105UQX Mate efflux family protein FOC88_RS20190 ENOG4108JQ7 (ABC) transporter FOC88_RS20200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_RS20205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_RS20220 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC88_RS20235 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC88_RS20240 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC88_RS20265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC88_RS20275 ENOG4108KP7 hydrolase FOC88_RS20285 ENOG41073B9 FOC88_RS20290 ENOG4107AYK membrAne FOC88_RS20300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_RS20310 ENOG4105QNR S1 RNA binding domain protein FOC88_RS20330 ENOG4105BZU Histidine kinase FOC88_RS20335 ENOG4105CH6 catalase FOC88_RS20340 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC88_RS20345 ENOG4105CAQ asparagine synthetase FOC88_RS20370 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_RS20435 ENOG4105XVF Competence transcription factor FOC88_RS20465 ENOG4107QP3 malate synthase g FOC88_RS20490 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC88_RS20515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS20535 ENOG41086D8 Transcriptional regulator FOC88_RS20540 ENOG4108AEY RNA polymerase sigma factor FOC88_RS20550 ENOG4107TVP HD domain protein FOC88_RS20555 ENOG4107RN3 metallophosphoesterase FOC88_RS20575 ENOG4105CEY Amp-dependent synthetase and ligase FOC88_RS20585 ENOG4105DF9 Lipoate-protein, ligase FOC88_RS20590 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC88_RS20595 ENOG4106AXD FOC88_RS20605 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC88_RS20625 ENOG4105ECB domain protein FOC88_RS20660 ENOG4105C1Q protoporphyrinogen oxidase FOC88_RS20675 ENOG4105BZ4 penicillin-binding protein FOC88_RS20680 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC88_RS20685 ENOG4105CKV Membrane FOC88_RS20690 ENOG410905X membrane-flanked domain protein FOC88_RS20730 ENOG4105CKV Membrane FOC88_RS20735 ENOG410905X membrane-flanked domain protein FOC88_RS20770 ENOG4105K59 histidine triad (HIT) protein FOC88_RS20795 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC88_RS20800 ENOG4105EEM helicase FOC88_RS20810 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS20815 ENOG4105C57 major facilitator superfamily FOC88_RS20830 ENOG4105CNI cell division protein FtsW FOC88_RS20840 ENOG4105EMN RNA polymerase sigma factor FOC88_RS20855 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC88_RS20870 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC88_RS20890 ENOG4108MUZ hydrolase FOC88_RS20940 ENOG4106D4I domain protein FOC88_RS20945 ENOG4107VRP DNA repair exonuclease FOC88_RS21000 ENOG4105BZU Histidine kinase FOC88_RS21005 ENOG4105BZU Histidine kinase FOC88_RS21010 ENOG4108MJI response regulator FOC88_RS21020 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS21030 ENOG4105WN5 stage II sporulation protein FOC88_RS21095 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC88_RS21110 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC88_RS21120 ENOG4105CMT Dihydroxyacetone kinase FOC88_RS21130 ENOG4105CMT Dihydroxyacetone kinase FOC88_RS21150 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC88_RS21165 ENOG4108IG5 Transcriptional regulator FOC88_RS21170 ENOG4107P5I polyketide synthase FOC88_RS21215 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS21255 ENOG4105CDU Replicative dna helicase FOC88_RS21340 ENOG4108MRH transcriptional regulatory protein FOC88_RS21350 ENOG4105CSH Transporter FOC88_RS21365 ENOG4108JQ7 (ABC) transporter FOC88_RS21375 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_RS21445 ENOG4105DER m42 family FOC88_RS21475 ENOG4105CGU Enoyl-CoA hydratase FOC88_RS21485 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC88_RS21495 ENOG4106AKK s-layer domain-containing protein FOC88_RS21535 ENOG4105CHH sulfate transporter FOC88_RS21550 ENOG4105D4P Coproporphyrinogen iii oxidase FOC88_RS21555 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC88_RS21575 ENOG4107FQX Alpha-acetolactate decarboxylase FOC88_RS21610 ENOG410839P FOC88_RS21625 ENOG4105CDA abc transporter atp-binding protein FOC88_RS21630 ENOG4105DRP amino acid AbC transporter FOC88_RS21640 ENOG4105BZ1 (ABC) transporter FOC88_RS21645 ENOG4105BZ1 (ABC) transporter FOC88_RS21650 ENOG4105C26 Dehydrogenase FOC88_RS21660 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC88_RS21665 ENOG4105D5Q Arginine ornithine antiporter FOC88_RS21675 ENOG4105CH6 catalase FOC88_RS21680 ENOG4107RKG DJ-1/PfpI family FOC88_RS21690 ENOG4105E5W Transporter FOC88_RS21695 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC88_RS21705 ENOG4105NF4 modulator of drug activity FOC88_RS21730 ENOG4105KPY Small multidrug resistance protein FOC88_RS21745 ENOG4108YXU transcriptional regulator AsnC family FOC88_RS21785 ENOG4106KNT transcriptional regulator FOC88_RS21795 ENOG4107RWR Sodium hydrogen exchanger FOC88_RS21800 ENOG4105CUB amino acid FOC88_RS21835 ENOG4107T5V SNARE associated Golgi FOC88_RS21870 ENOG4105WEF catalase FOC88_RS21900 ENOG4105C19 ABC transporter FOC88_RS21905 ENOG4107RBB ABC transporter, permease FOC88_RS21910 ENOG41069ER domain protein FOC88_RS21930 ENOG4105VZJ PTS System FOC88_RS21935 ENOG4105VCP PTS System FOC88_RS21940 ENOG4105EMD TRANSCRIPTIONal FOC88_RS21965 ENOG4108KGH TRANSCRIPTIONal FOC88_RS21975 ENOG41087NI Sulfite exporter TauE/SafE FOC88_RS21980 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC88_RS21990 ENOG4105VFE sira family FOC88_RS21995 ENOG4105VFE sira family FOC88_RS22000 ENOG4107TPS domain protein FOC88_RS22005 ENOG4105VFE sira family FOC88_RS22010 ENOG4105XTG Pfam:DUF156 FOC88_RS22015 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC88_RS22025 ENOG4108TCS Glutamyl endopeptidase FOC88_RS22030 ENOG4105ED1 spovr family FOC88_RS22035 ENOG4107Y03 Nitroreductase FOC88_RS22055 ENOG4108B31 Spore germination protein FOC88_RS22090 ENOG4105C5Y PTS System FOC88_RS22110 ENOG4108PXI ErfK YbiS YcfS YnhG FOC88_RS22120 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_RS22145 ENOG4108INS Transcriptional regulator FOC88_RS22195 ENOG4105DWF phosphomethylpyrimidine kinase FOC88_RS22200 ENOG4105D06 uba thif-type nad fad binding protein FOC88_RS22215 ENOG41080HI glycine oxidase FOC88_RS22220 ENOG4108VEU Thiamine monophosphate synthase FOC88_RS22230 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC88_RS22240 ENOG4105ETU transcriptional activator (TenA FOC88_RS22260 ENOG41080XQ Signal transduction protein with cbs domains FOC88_RS22385 ENOG4105E2Z phosphate ABC transporter (Permease FOC88_RS22390 ENOG4105C8U phosphate abc transporter FOC88_RS22395 ENOG4105CVA phosphate FOC88_RS22400 ENOG4105CE1 Ferrous iron transport protein b FOC88_RS22405 ENOG4105CE1 Ferrous iron transport protein b FOC88_RS22410 ENOG4105CE1 Ferrous iron transport protein b FOC88_RS22415 ENOG4108NHD germination protein FOC88_RS22430 ENOG4105E1V na solute symporter FOC88_RS22435 ENOG4106CAD Protein of unknown function (DUF3311) FOC88_RS22450 ENOG4108IQI permease FOC88_RS22455 ENOG4105E2S oxidase) subunit II FOC88_RS22460 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC88_RS22485 ENOG4105MA6 gCN5-related N-acetyltransferase FOC88_RS22500 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_RS22505 ENOG4105C85 amino acid FOC88_RS22525 ENOG4105DUX Transporter FOC88_RS22535 ENOG4107D63 FOC88_RS22540 ENOG4105VZ8 Transcriptional regulator FOC88_RS22545 ENOG41069ER domain protein FOC88_RS22550 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC88_RS22615 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC88_RS22620 ENOG4105CNN ABC, transporter FOC88_RS22635 ENOG4108RVA ribokinase FOC88_RS22640 ENOG4105ETE Transcriptional regulator (LacI family FOC88_RS22645 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC88_RS22650 ENOG41067TZ transcriptional regulator, MarR family FOC88_RS22655 ENOG4105CXY transporter FOC88_RS22665 ENOG4108JQ7 (ABC) transporter FOC88_RS22670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_RS22690 ENOG41068KF Universal stress protein FOC88_RS22695 ENOG4105CHH sulfate transporter FOC88_RS22705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS22710 ENOG4105BZU Histidine kinase FOC88_RS22715 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC88_RS22720 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC88_RS22740 ENOG4105GFR rna polymerase sigma factor FOC88_RS22755 ENOG4108IQI permease FOC88_RS22760 ENOG4105DRP amino acid AbC transporter FOC88_RS22765 ENOG4105EAD ABC transporter FOC88_RS22770 ENOG4105CT1 (ABC) transporter FOC88_RS22775 ENOG4105CDA abc transporter atp-binding protein FOC88_RS22780 ENOG4105BZG amino acid carrier protein FOC88_RS22785 ENOG4105CRN Aminoglycoside phosphotransferase FOC88_RS22795 ENOG4105E1K spore germination protein FOC88_RS22810 ENOG4105CG3 alpha amylase, catalytic region FOC88_RS22815 ENOG4105C5Y PTS System FOC88_RS22820 ENOG4107414 GntR family transcriptional regulator FOC88_RS22825 ENOG4105D5Q Arginine ornithine antiporter FOC88_RS22830 ENOG4105BZU Histidine kinase FOC88_RS22845 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC88_RS22850 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC88_RS22855 ENOG4107T89 von Willebrand factor, type A FOC88_RS22865 ENOG4105EXW epimerase dehydratase FOC88_RS22875 ENOG4105DMQ Methyltransferase FOC88_RS22880 ENOG4105E0A ABC, transporter FOC88_RS22885 ENOG4108IHU transport system permease protein FOC88_RS22890 ENOG4105DQ5 transport system permease protein FOC88_RS22895 ENOG4108MES Periplasmic binding protein FOC88_RS22900 ENOG4105DUX Transporter FOC88_RS22915 ENOG4105DAA L-lactate FOC88_RS22920 ENOG4108IJ0 Aspartate ammonia-lyase FOC88_RS22925 ENOG4105C37 (CBS) domain FOC88_RS22930 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC88_RS22935 ENOG4105D9N nucleoside FOC88_RS22940 ENOG4108KGH TRANSCRIPTIONal FOC88_RS22945 ENOG41073R8 VanW family FOC88_RS22980 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC88_RS22985 ENOG4105C59 p-type ATPase FOC88_RS22995 ENOG4105CUB amino acid FOC88_RS23015 ENOG4108JB9 formate dehydrogenase FOC88_RS23020 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC88_RS23025 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC88_RS23030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS23035 ENOG4105BZU Histidine kinase FOC88_RS23045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC88_RS23050 ENOG4108UZ3 Transporter FOC88_RS23060 ENOG4105C6K Malic enzyme FOC88_RS23070 ENOG4108MRH transcriptional regulatory protein FOC88_RS23095 ENOG4105US7 Histidine kinase FOC88_RS23100 ENOG4108STX response regulator FOC88_RS23105 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC88_RS23110 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC88_RS23115 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC88_RS23120 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC88_RS23125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS23130 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC88_RS23150 ENOG4105D4T Citrate transporter FOC88_RS23155 ENOG4108V9W transcriptional regulatory protein FOC88_RS23160 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC88_RS23170 ENOG4105DZ6 Band 7 protein FOC88_RS23185 ENOG4105C94 Transporter FOC88_RS23205 ENOG4105CYN Serine protein kinase FOC88_RS23210 ENOG4105BZU Histidine kinase FOC88_RS23215 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC88_RS23225 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC88_RS23235 ENOG4107ZQN disulfide bond FOC88_RS23240 ENOG4108JQC penicillin-binding protein 1A FOC88_RS23355 ENOG4105G5W regulator Fur family FOC88_RS23360 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC88_RS23380 ENOG4108IUW ABC transporter FOC88_RS23390 ENOG4105CBC glutamate synthase FOC88_RS23395 ENOG4107NBY Membrane FOC88_RS23400 ENOG4105BZ1 (ABC) transporter FOC88_RS23420 ENOG4106BXE FOC88_RS23425 ENOG4105CEN a g-specific adenine glycosylase FOC88_RS23430 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC88_RS23460 ENOG4105ECP epimerase FOC88_RS23465 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC88_RS23485 ENOG4105F1A Pyruvate formate-lyase FOC88_RS23505 ENOG4105C3I Nad-dependent epimerase dehydratase FOC88_RS23510 ENOG4107QQG Dehydrogenase FOC88_RS23515 ENOG4105CKK Glycosyl transferase, family 2 FOC88_RS23530 ENOG4108A04 Beta-lactamase FOC88_RS23580 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC88_RS23615 ENOG4105UPD Calcium Proton FOC88_RS23620 ENOG410606W general stress protein FOC88_RS23635 ENOG4107ZTW SNARE associated Golgi FOC88_RS23645 ENOG4105C3F Signal peptidase i FOC88_RS23660 ENOG4108IPJ Membrane FOC88_RS23665 ENOG4105C59 p-type ATPase FOC88_RS23670 ENOG4107U9T Pfam:Ribonuclease_BN FOC88_RS23680 ENOG4105KJF protein tyrosine phosphatase FOC88_RS23700 ENOG4108TTB tellurium resistance protein FOC88_RS23705 ENOG4107TS3 membrane protein, TerC FOC88_RS23710 ENOG4106FN3 tellurium resistance protein FOC88_RS23715 ENOG4106FN3 tellurium resistance protein FOC88_RS23720 ENOG4108N0M stress protein FOC88_RS23750 ENOG4105DEU major facilitator superfamily FOC88_RS23770 ENOG41062JF Transcriptional regulator FOC88_RS23800 ENOG4105C5H ABC transporter FOC88_RS23815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC88_RS23830 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC88_RS23860 ENOG4105CI1 PTS System FOC88_RS23880 ENOG4105C5B carbamate kinase FOC88_RS23905 ENOG4105C8Q Methyl-accepting chemotaxis FOC88_RS23915 ENOG4105EAB amino acid AbC transporter FOC88_RS23920 ENOG4105E5Q amino acid AbC transporter FOC88_RS23935 ENOG4105D2S major facilitator superfamily FOC88_RS23940 ENOG410756H nucleotidyltransferase FOC88_RS23985 ENOG4106UIA FOC88_RS23990 ENOG4106UIA FOC88_RS24010 ENOG4108V5C ABC transporter FOC88_RS24015 ENOG4105DQ5 transport system permease protein FOC88_RS24020 ENOG4105EHG Permease protein FOC88_RS24040 ENOG4105D3R alkyl hydroperoxide reductase FOC88_RS24060 ENOG4105DFD Na H antiporter FOC88_RS24070 ENOG4105DTQ mandelate racemase muconate lactonizing FOC88_RS24085 ENOG4108W15 Protein of unknown function (DUF1456) FOC88_RS24100 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC88_RS24105 ENOG4105D9N nucleoside FOC88_RS24125 ENOG4105KPY Small multidrug resistance protein FOC88_RS24130 ENOG4105C26 Dehydrogenase FOC88_RS24140 ENOG4108JPW Aminotransferase FOC88_RS24145 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC88_RS24150 ENOG4105CBD Diacylglycerol kinase FOC88_RS24170 ENOG4107I77 yiaA/B two helix domain FOC88_RS24175 ENOG410834F Transcriptional regulator FOC88_RS24195 ENOG4105D01 (LipO)protein FOC88_RS24200 ENOG4108UMI ABC transporter, permease FOC88_RS24205 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS24210 ENOG4108W2Y isochorismatase FOC88_RS24240 ENOG4105C4R Atp-dependent dna helicase FOC88_RS24265 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC88_RS24275 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC88_RS24300 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC88_RS24310 ENOG4105C83 adenylosuccinate lyase FOC88_RS24315 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC88_RS24320 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC88_RS24340 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC88_RS24385 ENOG4108SHN Glycosyl transferase, family 2 FOC88_RS24405 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC88_RS24435 ENOG4107ZXU DSBA oxidoreductase FOC88_RS24460 ENOG4105BZU Histidine kinase FOC88_RS24470 ENOG4105C7N Xanthine uracil vitamin C permease FOC88_RS24490 ENOG4108TYN CAAX amino terminal protease family protein FOC88_RS24505 ENOG4105C5H ABC transporter FOC88_RS24515 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC88_RS24520 ENOG41072GX Peptidase M22 Glycoprotease FOC88_RS24525 ENOG4105K8N protein family UPF0079, ATPase FOC88_RS24625 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC88_RS24635 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC88_RS24640 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC88_RS24650 ENOG4107ZXI Rhomboid family FOC88_RS24665 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC88_RS24670 ENOG4105CPF Cell wall formation (By similarity) FOC88_RS24675 ENOG4108SC4 )-transporter FOC88_RS24685 ENOG4105ERH Fumarylacetoacetate hydrolase FOC88_RS24690 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC88_RS24720 ENOG410667J hydrolase FOC88_RS24725 ENOG4108JQ7 (ABC) transporter FOC88_RS24730 ENOG4105C3U ABC transporter FOC88_RS24735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_RS24745 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC88_RS24755 ENOG4108KYE ABC-2 type transporter FOC88_RS24760 ENOG41090VJ ABC-2 type transporter FOC88_RS24765 ENOG4105CJ1 ABC, transporter FOC88_RS24770 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_RS24775 ENOG4105BZU Histidine kinase FOC88_RS24780 ENOG4105C5H ABC transporter FOC88_RS24805 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC88_RS24810 ENOG4108RE7 deoxyribonuclease FOC88_RS24820 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC88_RS24840 ENOG4105F6E Acyl-transferase FOC88_RS24870 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC88_RS24875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC88_RS24880 ENOG4105E0C molybdate abc transporter FOC88_RS24890 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC88_RS24895 ENOG4105II7 pyrroline-5-carboxylate reductase FOC88_RS24905 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC88_RS24910 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC88_RS24940 ENOG4108JQ7 (ABC) transporter FOC88_RS24945 ENOG4105C3U ABC transporter FOC88_RS24950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC88_RS24955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC88_RS24970 ENOG4105C2C drug resistance transporter, Bcr CflA FOC88_RS24985 ENOG4105IQ5 FAD linked oxidase domain protein FOC88_RS25000 ENOG4105D01 (LipO)protein FOC88_RS25005 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC88_RS25010 ENOG4108UMI ABC transporter, permease FOC88_RS25015 ENOG4108PSK reductase FOC88_RS25050 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC88_RS25060 ENOG4105CMG Carbohydrate kinase FOC88_RS25070 ENOG4108VQT Alpha beta hydrolase fold protein FOC88_RS25090 ENOG4107U5W ybbr family FOC88_RS25095 ENOG4105C8B TIGR00159 family FOC88_RS25175 ENOG4108NMV polysaccharide deacetylase FOC88_RS25190 ENOG4105D1F ATP-binding protein FOC88_RS25220 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC88_RS25265 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_RS25275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC88_RS25405 ENOG4105XPM ribosomal protein FOC88_RS25420 ENOG4107Y49 methyltransferase FOC88_RS25445 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC88_RS25460 ENOG4105QIV RNA polymerase FOC88_RS25465 ENOG4105M0M Tetracycline resistance protein FOC88_RS25470 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC88_RS25485 ENOG4105D7W serine acetyltransferase FOC88_RS25505 ENOG4105CTP PilT protein domain protein FOC88_RS25515 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC88_RS25530 ENOG4108Z0C Uvrb UvrC protein FOC88_RS25620 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC88_RS25630 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC88_RS25635 ENOG4105KRF dihydroneopterin aldolase FOC88_RS25640 ENOG4105EEI dihydropteroate synthase FOC88_RS25645 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC88_RS25650 ENOG4105DDQ anthranilate synthase FOC88_RS25655 ENOG4105CRQ synthase (Component I) FOC88_RS25660 ENOG4105C6T cysteine synthase FOC88_RS25675 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC88_RS25680 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC88_RS25705 ENOG41060GV RNA binding s1 domain protein FOC88_RS25720 ENOG4105VYY sporulation protein yabp FOC88_RS25725 ENOG41082I2 s4 domain protein FOC88_RS25730 ENOG4108IY2 MazG family FOC88_RS25740 ENOG4108M14 stage v sporulation protein t FOC88_RS25745 ENOG4108JA2 transcriptioN-repair coupling factor FOC88_RS25775 ENOG4105KME endoribonuclease L-psp FOC88_RS25780 ENOG4105DFT pur operon repressor FOC88_RS25795 ENOG4105W42 Veg protein FOC88_RS25800 ENOG4105XFA sporulation peptidase YabG FOC88_RS25810 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC88_RS25815 ENOG4105F8V Hydrolase, tatD family FOC88_RS25825 ENOG4105KRN Transcriptional regulator, abrb family FOC88_RS25830 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC88_RS25840 ENOG41060K3 Methyltransferase FOC88_RS25850 ENOG4105MA4 psp1 domain protein FOC88_RS25855 ENOG4105FA2 dna polymerase iii FOC88_RS25865 ENOG4105CXN decarboxylase FOC88_RS25900 ENOG41067KS pro-sigma K processing FOC88_RS25920 ENOG4105C6E dna polymerase iii FOC88_RS25930 ENOG4108Z6B deaminase FOC88_RS25935 ENOG4105GTG Isochorismatase FOC88_RS25945 ENOG4105ZMH deoxynucleoside kinase FOC88_RS25980 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC88_RS26015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC88_RS26030 ENOG410848D S4 domain protein YaaA FOC88_RS26035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC88_RS26055 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC88_RS26085 ENOG4107QJE Chromosome Partitioning Protein FOC88_RS26090 ENOG4105FA0 parb-like partition protein FOC88_RS26095 ENOG4108ZDA Sporulation protein YyaC FOC88_RS26100 ENOG4105D8X mechanosensitive ion channel FOC88_RS26105 ENOG4105VDK protein, conserved in bacteria FOC88_RS26110 ENOG4105C3G gtp-binding protein FOC88_RS26120 ENOG4108UUM single-stranded DNA-binding protein FOC88_RS26130 ENOG4108XMW Membrane FOC88_RS26135 ENOG4105BZR domain protein FOC88_RS26145 ENOG4105CDU Replicative dna helicase FOC88_RS26175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS26180 ENOG4105BZU Histidine kinase FOC88_RS26195 ENOG4105Q2H domain protein FOC88_RS26200 ENOG4105C0H protease FOC88_RS26220 ENOG4105DPN Oligoendopeptidase f FOC88_RS26235 ENOG4105C1J atp-dependent rna helicase FOC88_RS26245 ENOG4108UT2 hemolysin iii FOC88_RS26250 ENOG4105CMR udp-glucose 4-epimerase FOC88_RS26260 ENOG4105IW1 AmiS UreI transporter FOC88_RS26270 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC88_RS26285 ENOG4107RGD Major Facilitator superfamily FOC88_RS26290 ENOG4108HRK Histidine kinase FOC88_RS26295 ENOG4105DY9 regulatoR FOC88_RS26310 ENOG4106F5Q Membrane FOC88_RS26315 ENOG4105E0X reductase FOC88_RS26325 ENOG41067SE Tetr family transcriptional regulator FOC88_RS26330 ENOG4105CKK Glycosyl transferase, family 2 FOC88_RS26350 ENOG4105C5H ABC transporter FOC88_RS26355 ENOG4105JEU Glycosyl transferase, family 2 FOC88_RS26365 ENOG4108S4H thioesterase Superfamily protein FOC88_RS26375 ENOG4106YBV Methyl-accepting chemotaxis FOC88_RS26380 ENOG4105EN6 Membrane FOC88_RS26400 ENOG41079KZ Major Facilitator Superfamily FOC88_RS26405 ENOG4105DY9 regulatoR FOC88_RS26410 ENOG4105D22 carbon starvation protein FOC88_RS26415 ENOG4105VCD cytoplasmic protein FOC88_RS26420 ENOG4105BZU Histidine kinase FOC88_RS26425 ENOG4105DWF phosphomethylpyrimidine kinase FOC88_RS26430 ENOG4105BZU Histidine kinase FOC88_RS26435 ENOG4105WH1 Two component transcriptional regulator luxr family FOC88_RS26445 ENOG4108Y4K DNA-binding transcriptional activator FOC88_RS26470 ENOG4105D6E homoserine dehydrogenase FOC88_RS26485 ENOG41090WU lipolytic protein G-D-S-L family FOC88_RS26490 ENOG4105CJ1 ABC, transporter FOC88_RS26495 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC88_RS26505 ENOG4105VCH membrane FOC88_RS26510 ENOG410667J hydrolase FOC88_RS26520 ENOG4107SVH Potassium channel protein FOC88_RS26540 ENOG4108VKI Cell wall hydrolase FOC88_RS26555 ENOG4108IJ2 phosphate acetyltransferase FOC88_RS26570 ENOG4108VCI transcription factor, rsfa family FOC88_RS26580 ENOG4105DQ5 transport system permease protein FOC88_RS26585 ENOG4105EHG Permease protein FOC88_RS26590 ENOG4105E0A ABC, transporter FOC88_RS26595 ENOG4108MES Periplasmic binding protein FOC88_RS26600 ENOG4105DCI Phosphohydrolase FOC88_RS26605 ENOG41069HH 4-oxalocrotonate tautomerase FOC88_RS26610 ENOG4108Z4T Peptidase M50 FOC88_RS26615 ENOG4108XFG YwhD family FOC88_RS26620 ENOG4105BZ4 penicillin-binding protein FOC88_RS26625 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC88_RS26630 ENOG4107SWG transcriptional regulator MERR family FOC88_RS26635 ENOG4105DXB Major Facilitator superfamily FOC88_RS26645 ENOG4105CYW agmatinase FOC88_RS26665 ENOG410684U Domain of unknown function (DUF1934) FOC88_RS26675 ENOG4105EMN RNA polymerase sigma factor FOC88_RS26695 ENOG4105IIU Aminopeptidase FOC88_RS26705 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC88_RS26710 ENOG4108M15 ABC transporter FOC88_RS26715 ENOG4105KCT ABC transporter FOC88_RS26720 ENOG4105BZU Histidine kinase FOC88_RS26745 ENOG4105BZU Histidine kinase FOC88_RS26760 ENOG4105DF6 Fe-S oxidoreductase FOC88_RS26770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC88_RS26775 ENOG4105C1G acyl-Coa dehydrogenase FOC88_RS26780 ENOG4105C1G acyl-Coa dehydrogenase FOC88_RS26820 ENOG4105CBT Fructose-1,6-bisphosphatase FOC88_RS26825 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC88_RS26845 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC88_RS26850 ENOG4108ZXQ stage ii sporulation protein r FOC88_RS26860 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC88_RS26875 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC88_RS26880 ENOG4108VGI doxx family FOC88_RS26895 ENOG4108YZG isomerase FOC88_RS26925 ENOG41062M3 atp synthase FOC88_RS26930 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC88_RS26980 ENOG4105BZU Histidine kinase FOC88_RS26995 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC88_RS27000 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC88_RS27025 ENOG4105D65 subunit l FOC88_RS27030 ENOG4105C8S subunit m FOC88_RS27035 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC88_RS27040 ENOG4106778 Protein of unknown function (DUF1146) FOC88_RS27060 ENOG4105DY9 regulatoR FOC88_RS27075 ENOG4105FRN stage II sporulation protein FOC88_RS27090 ENOG4107BJW polysaccharide deacetylase FOC88_RS27095 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC88_RS27125 ENOG4107VDP teichoic acid biosynthesis FOC88_RS27145 ENOG4105EY8 ABC transporter FOC88_RS27150 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC88_RS27170 ENOG4105CMR udp-glucose 4-epimerase FOC88_RS27175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC88_RS27180 ENOG4105BZU Histidine kinase FOC88_RS27195 ENOG4105CXY transporter FOC88_RS27205 ENOG4105C19 ABC transporter FOC88_RS27210 ENOG4107RBB ABC transporter, permease FOC88_RS27220 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC88_RS27250 ENOG4105C0D helicase FOC88_RS27255 ENOG4105KBK Zinc finger, swim domain protein FOC88_RS27280 ENOG41069ER domain protein FOC88_RS27285 ENOG4105C94 Transporter FOC88_RS27290 ENOG4107R8N Glycosyl transferase, family 2 FOC88_RS27380 ENOG4106CVF DNA replication protein FOC88_RS27430 ENOG4108IMY Transcriptional regulator FOC88_RS27510 ENOG4107QJE Chromosome Partitioning Protein FOC88_RS27530 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC88_RS27555 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC88_RS27635 ENOG41060SN FOC88_RS27665 ENOG4106CGH Phage Mu protein F like protein FOC88_RS27670 ENOG4108MDF Phage Portal Protein FOC88_RS27720 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)