locus-tag class description HBA75_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBA75_RS00015 ENOG410848D S4 domain protein YaaA HBA75_RS00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBA75_RS00145 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HBA75_RS00180 ENOG4105ZMH deoxynucleoside kinase HBA75_RS00190 ENOG4105GTG Isochorismatase HBA75_RS00195 ENOG4108Z6B deaminase HBA75_RS00205 ENOG4105C6E dna polymerase iii HBA75_RS00225 ENOG41067KS pro-sigma K processing HBA75_RS00260 ENOG4105CXN decarboxylase HBA75_RS00270 ENOG4105FA2 dna polymerase iii HBA75_RS00275 ENOG4105MA4 psp1 domain protein HBA75_RS00285 ENOG41060K3 Methyltransferase HBA75_RS00305 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HBA75_RS00310 ENOG4105KRN Transcriptional regulator, abrb family HBA75_RS00315 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HBA75_RS00320 ENOG4105F8V Hydrolase, tatD family HBA75_RS00325 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HBA75_RS00335 ENOG4105XFA sporulation peptidase YabG HBA75_RS00340 ENOG4105W42 Veg protein HBA75_RS00355 ENOG4105DFT pur operon repressor HBA75_RS00360 ENOG4105KME endoribonuclease L-psp HBA75_RS00380 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HBA75_RS00390 ENOG4108JA2 transcriptioN-repair coupling factor HBA75_RS00395 ENOG4108M14 stage v sporulation protein t HBA75_RS00405 ENOG4108IY2 MazG family HBA75_RS00410 ENOG41082I2 s4 domain protein HBA75_RS00415 ENOG4105VYY sporulation protein yabp HBA75_RS00430 ENOG41060GV RNA binding s1 domain protein HBA75_RS00450 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HBA75_RS00455 ENOG4108UGV hypoxanthine phosphoribosyltransferase HBA75_RS00460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HBA75_RS00475 ENOG4105C6T cysteine synthase HBA75_RS00480 ENOG4105CRQ synthase (Component I) HBA75_RS00485 ENOG4105DDQ anthranilate synthase HBA75_RS00490 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HBA75_RS00495 ENOG4105EEI dihydropteroate synthase HBA75_RS00500 ENOG4105KRF dihydroneopterin aldolase HBA75_RS00505 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HBA75_RS00515 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HBA75_RS00605 ENOG4108Z0C Uvrb UvrC protein HBA75_RS00620 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HBA75_RS00630 ENOG4105CTP PilT protein domain protein HBA75_RS00635 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HBA75_RS00650 ENOG4105D7W serine acetyltransferase HBA75_RS00665 ENOG4105C2N RNA methyltransferase TrmH family group 3 HBA75_RS00670 ENOG4105M0M Tetracycline resistance protein HBA75_RS00675 ENOG4105QIV RNA polymerase HBA75_RS00690 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HBA75_RS00715 ENOG4107Y49 methyltransferase HBA75_RS00730 ENOG4105XPM ribosomal protein HBA75_RS00860 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HBA75_RS00870 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_RS00905 ENOG4108JJB ABC transporter HBA75_RS00910 ENOG4108JJB ABC transporter HBA75_RS00915 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HBA75_RS00920 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HBA75_RS00945 ENOG4105D1F ATP-binding protein HBA75_RS00960 ENOG4108NMV polysaccharide deacetylase HBA75_RS01030 ENOG4105C8B TIGR00159 family HBA75_RS01035 ENOG4107U5W ybbr family HBA75_RS01050 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HBA75_RS01075 ENOG4108PSK reductase HBA75_RS01080 ENOG4108UMI ABC transporter, permease HBA75_RS01085 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS01090 ENOG4105D01 (LipO)protein HBA75_RS01095 ENOG4105CB2 alcohol dehydrogenase HBA75_RS01105 ENOG4105IQ5 FAD linked oxidase domain protein HBA75_RS01120 ENOG4105C2C drug resistance transporter, Bcr CflA HBA75_RS01135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HBA75_RS01145 ENOG4105C3U ABC transporter HBA75_RS01150 ENOG4108JQ7 (ABC) transporter HBA75_RS01185 ENOG4108J59 Extracellular solute-binding protein, family 5 HBA75_RS01190 ENOG4108J59 Extracellular solute-binding protein, family 5 HBA75_RS01200 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_RS01210 ENOG4105E0C molybdate abc transporter HBA75_RS01215 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HBA75_RS01225 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HBA75_RS01235 ENOG4105EGI Transcriptional regulator HBA75_RS01255 ENOG4105F6E Acyl-transferase HBA75_RS01275 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HBA75_RS01290 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HBA75_RS01315 ENOG4105C5H ABC transporter HBA75_RS01325 ENOG4105DEF Extracellular solute-binding protein, family 5 HBA75_RS01355 ENOG4105C3U ABC transporter HBA75_RS01360 ENOG4108JQ7 (ABC) transporter HBA75_RS01365 ENOG410667J hydrolase HBA75_RS01395 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HBA75_RS01400 ENOG4105ERH Fumarylacetoacetate hydrolase HBA75_RS01410 ENOG4105CUB amino acid HBA75_RS01415 ENOG4108SC4 )-transporter HBA75_RS01420 ENOG4105CPF Cell wall formation (By similarity) HBA75_RS01425 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HBA75_RS01450 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HBA75_RS01455 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HBA75_RS01465 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HBA75_RS01580 ENOG4105K8N protein family UPF0079, ATPase HBA75_RS01585 ENOG41072GX Peptidase M22 Glycoprotease HBA75_RS01590 ENOG410801F ribosomal-protein-alanine acetyltransferase HBA75_RS01595 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HBA75_RS01600 ENOG4105C5H ABC transporter HBA75_RS01615 ENOG4108TYN CAAX amino terminal protease family protein HBA75_RS01630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HBA75_RS01635 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_RS01645 ENOG4105BZU Histidine kinase HBA75_RS01670 ENOG4107ZXU DSBA oxidoreductase HBA75_RS01715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS01745 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_RS01795 ENOG4108SHN Glycosyl transferase, family 2 HBA75_RS01815 ENOG4105SX7 Transporter HBA75_RS01840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HBA75_RS01845 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HBA75_RS01850 ENOG4105C83 adenylosuccinate lyase HBA75_RS01860 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HBA75_RS01885 ENOG4108V3E phosphoribosylglycinamide formyltransferase HBA75_RS01895 ENOG4105C12 Phosphoribosylglycinamide synthetase HBA75_RS01920 ENOG4105C4R Atp-dependent dna helicase HBA75_RS01925 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HBA75_RS01945 ENOG4108W2Y isochorismatase HBA75_RS01950 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS01955 ENOG4108UMI ABC transporter, permease HBA75_RS01960 ENOG4105D01 (LipO)protein HBA75_RS01980 ENOG410834F Transcriptional regulator HBA75_RS01985 ENOG4107I77 yiaA/B two helix domain HBA75_RS02005 ENOG4105CBD Diacylglycerol kinase HBA75_RS02015 ENOG4108JPW Aminotransferase HBA75_RS02025 ENOG4105C26 Dehydrogenase HBA75_RS02030 ENOG4105KPY Small multidrug resistance protein HBA75_RS02065 ENOG4105D9N nucleoside HBA75_RS02070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HBA75_RS02075 ENOG4105VTR Integrase HBA75_RS02090 ENOG41067QW Transcriptional regulator HBA75_RS02235 ENOG4108A04 Beta-lactamase HBA75_RS02250 ENOG4105CKK Glycosyl transferase, family 2 HBA75_RS02255 ENOG4107QQG Dehydrogenase HBA75_RS02260 ENOG4105C3I Nad-dependent epimerase dehydratase HBA75_RS02280 ENOG4105F1A Pyruvate formate-lyase HBA75_RS02300 ENOG4105CI2 imidazolone-5-propionate hydrolase HBA75_RS02305 ENOG4105ECP epimerase HBA75_RS02335 ENOG41067AE Membrane-bound metal-dependent hydrolase HBA75_RS02340 ENOG4105CEN a g-specific adenine glycosylase HBA75_RS02345 ENOG4106BXE HBA75_RS02365 ENOG4105BZ1 (ABC) transporter HBA75_RS02370 ENOG4107NBY Membrane HBA75_RS02375 ENOG4105CBC glutamate synthase HBA75_RS02385 ENOG4108IUW ABC transporter HBA75_RS02405 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_RS02410 ENOG4105G5W regulator Fur family HBA75_RS02530 ENOG4108JQC penicillin-binding protein 1A HBA75_RS02535 ENOG4108R9S DSBA oxidoreductase HBA75_RS02545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HBA75_RS02555 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HBA75_RS02560 ENOG4105BZU Histidine kinase HBA75_RS02565 ENOG4105CYN Serine protein kinase HBA75_RS02585 ENOG4105C94 Transporter HBA75_RS02600 ENOG4105DZ6 Band 7 protein HBA75_RS02610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HBA75_RS02615 ENOG4108V9W transcriptional regulatory protein HBA75_RS02620 ENOG4105D4T Citrate transporter HBA75_RS02640 ENOG410836F Transposase HBA75_RS02650 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HBA75_RS02655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS02660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HBA75_RS02665 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HBA75_RS02670 ENOG4105BZ7 extracellular solute-binding protein family 1 HBA75_RS02680 ENOG4105DQ6 Transposase HBA75_RS02685 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HBA75_RS02690 ENOG4108STX response regulator HBA75_RS02695 ENOG41062D9 Histidine kinase HBA75_RS02720 ENOG4108MRH transcriptional regulatory protein HBA75_RS02730 ENOG4105C6K Malic enzyme HBA75_RS02740 ENOG4108UZ3 Transporter HBA75_RS02745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS02755 ENOG4105BZU Histidine kinase HBA75_RS02760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS02765 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HBA75_RS02770 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HBA75_RS02780 ENOG4108JB9 formate dehydrogenase HBA75_RS02800 ENOG4105CUB amino acid HBA75_RS02815 ENOG4105C59 p-type ATPase HBA75_RS02820 ENOG4105DAP Nicotinate phosphoribosyltransferase HBA75_RS02855 ENOG41073R8 VanW family HBA75_RS02860 ENOG4108KGH TRANSCRIPTIONal HBA75_RS02865 ENOG4105D9N nucleoside HBA75_RS02875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HBA75_RS02880 ENOG41085W3 Transposase HBA75_RS02885 ENOG4105C37 (CBS) domain HBA75_RS02890 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_RS02895 ENOG4105DAA L-lactate HBA75_RS02910 ENOG4105DUX Transporter HBA75_RS02915 ENOG4108MES Periplasmic binding protein HBA75_RS02920 ENOG4105DQ5 transport system permease protein HBA75_RS02925 ENOG4108IHU transport system permease protein HBA75_RS02930 ENOG4105E0A ABC, transporter HBA75_RS02935 ENOG4105DMQ Methyltransferase HBA75_RS02945 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS02955 ENOG4105EXW epimerase dehydratase HBA75_RS02960 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HBA75_RS02970 ENOG4107T89 von Willebrand factor, type A HBA75_RS02975 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HBA75_RS02980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_RS02990 ENOG4105BZU Histidine kinase HBA75_RS02995 ENOG4105D5Q Arginine ornithine antiporter HBA75_RS03000 ENOG4107414 GntR family transcriptional regulator HBA75_RS03005 ENOG4105C5Y PTS System HBA75_RS03010 ENOG4105CG3 alpha amylase, catalytic region HBA75_RS03025 ENOG4105E1K spore germination protein HBA75_RS03030 ENOG4105CRN Aminoglycoside phosphotransferase HBA75_RS03035 ENOG4105BZG amino acid carrier protein HBA75_RS03040 ENOG4105CDA abc transporter atp-binding protein HBA75_RS03045 ENOG4105CT1 (ABC) transporter HBA75_RS03050 ENOG4105EAD ABC transporter HBA75_RS03055 ENOG4105DRP amino acid AbC transporter HBA75_RS03060 ENOG4108IQI permease HBA75_RS03085 ENOG4105D29 Helix-turn-helix type 11 domain protein HBA75_RS03090 ENOG4105NAE bifunctional deaminase-reductase domain protein HBA75_RS03095 ENOG4105BZU Histidine kinase HBA75_RS03100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS03110 ENOG4105CHH sulfate transporter HBA75_RS03115 ENOG41068KF Universal stress protein HBA75_RS03125 ENOG4105CXY transporter HBA75_RS03130 ENOG41067TZ transcriptional regulator, MarR family HBA75_RS03135 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_RS03140 ENOG4105ETE Transcriptional regulator (LacI family HBA75_RS03145 ENOG4108RVA ribokinase HBA75_RS03155 ENOG4105C2J ABC transporter HBA75_RS03160 ENOG4105CNN ABC, transporter HBA75_RS03165 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HBA75_RS03220 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HBA75_RS03250 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_RS03255 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HBA75_RS03260 ENOG41069ER domain protein HBA75_RS03265 ENOG4105VZ8 Transcriptional regulator HBA75_RS03270 ENOG4107D63 HBA75_RS03285 ENOG4105DUX Transporter HBA75_RS03305 ENOG4105C85 amino acid HBA75_RS03310 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_RS03325 ENOG4105MA6 gCN5-related N-acetyltransferase HBA75_RS03345 ENOG4105CCU oxidase (Subunit III) HBA75_RS03350 ENOG4105BZ9 Cytochrome C oxidase, subunit I HBA75_RS03355 ENOG4105E2S oxidase) subunit II HBA75_RS03375 ENOG4106CAD Protein of unknown function (DUF3311) HBA75_RS03380 ENOG4105E1V na solute symporter HBA75_RS03395 ENOG4108NHD germination protein HBA75_RS03405 ENOG4105CE1 Ferrous iron transport protein b HBA75_RS03410 ENOG4105CE1 Ferrous iron transport protein b HBA75_RS03415 ENOG4105CE1 Ferrous iron transport protein b HBA75_RS03420 ENOG4105CVA phosphate HBA75_RS03425 ENOG4105C8U phosphate abc transporter HBA75_RS03430 ENOG4105E2Z phosphate ABC transporter (Permease HBA75_RS03560 ENOG41080XQ Signal transduction protein with cbs domains HBA75_RS03580 ENOG4105ETU transcriptional activator (TenA HBA75_RS03590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HBA75_RS03600 ENOG4108VEU Thiamine monophosphate synthase HBA75_RS03605 ENOG41080HI glycine oxidase HBA75_RS03620 ENOG4105D06 uba thif-type nad fad binding protein HBA75_RS03625 ENOG4105DWF phosphomethylpyrimidine kinase HBA75_RS03675 ENOG4108INS Transcriptional regulator HBA75_RS03685 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_RS03695 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HBA75_RS03715 ENOG4105C5Y PTS System HBA75_RS03730 ENOG4105K63 Thioredoxin HBA75_RS03750 ENOG4108B31 Spore germination protein HBA75_RS03775 ENOG4107Y03 Nitroreductase HBA75_RS03780 ENOG4105ED1 spovr family HBA75_RS03805 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HBA75_RS03810 ENOG4105XTG Pfam:DUF156 HBA75_RS03815 ENOG4105VFE sira family HBA75_RS03820 ENOG4107TPS domain protein HBA75_RS03825 ENOG4105VFE sira family HBA75_RS03830 ENOG4105VFE sira family HBA75_RS03835 ENOG41085GJ domain protein HBA75_RS03840 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HBA75_RS03845 ENOG41087NI Sulfite exporter TauE/SafE HBA75_RS03855 ENOG4108KGH TRANSCRIPTIONal HBA75_RS03880 ENOG4105EMD TRANSCRIPTIONal HBA75_RS03885 ENOG4105VCP PTS System HBA75_RS03890 ENOG4105VZJ PTS System HBA75_RS03910 ENOG41069ER domain protein HBA75_RS03915 ENOG4107RBB ABC transporter, permease HBA75_RS03920 ENOG4105C19 ABC transporter HBA75_RS03950 ENOG4105WEF catalase HBA75_RS03985 ENOG4107T5V SNARE associated Golgi HBA75_RS04020 ENOG4105CUB amino acid HBA75_RS04025 ENOG4107RWR Sodium hydrogen exchanger HBA75_RS04035 ENOG4106KNT transcriptional regulator HBA75_RS04075 ENOG4108YXU transcriptional regulator AsnC family HBA75_RS04080 ENOG4105CH7 arginosuccinase HBA75_RS04130 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HBA75_RS04135 ENOG4105E5W Transporter HBA75_RS04150 ENOG4107RKG DJ-1/PfpI family HBA75_RS04155 ENOG4105CH6 catalase HBA75_RS04165 ENOG4105D5Q Arginine ornithine antiporter HBA75_RS04170 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HBA75_RS04180 ENOG4105C26 Dehydrogenase HBA75_RS04185 ENOG4105BZ1 (ABC) transporter HBA75_RS04190 ENOG4105BZ1 (ABC) transporter HBA75_RS04200 ENOG4105DRP amino acid AbC transporter HBA75_RS04205 ENOG4105CDA abc transporter atp-binding protein HBA75_RS04220 ENOG410839P HBA75_RS04260 ENOG4107FQX Alpha-acetolactate decarboxylase HBA75_RS04280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_RS04285 ENOG4105D4P Coproporphyrinogen iii oxidase HBA75_RS04290 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS04305 ENOG4105CHH sulfate transporter HBA75_RS04335 ENOG4105CGU Enoyl-CoA hydratase HBA75_RS04355 ENOG4105DER m42 family HBA75_RS04375 ENOG4105CTU Proline racemase HBA75_RS04380 ENOG4105CIF Ornithine Cyclodeaminase HBA75_RS04395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HBA75_RS04405 ENOG4108JQ7 (ABC) transporter HBA75_RS04495 ENOG4108IBT Inherit from COG: transposase HBA75_RS04545 ENOG4105CSH Transporter HBA75_RS04555 ENOG4108MRH transcriptional regulatory protein HBA75_RS04650 ENOG4105CDU Replicative dna helicase HBA75_RS04675 ENOG41085W3 Transposase HBA75_RS04690 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_RS04720 ENOG4105F6J Alpha beta hydrolase fold HBA75_RS04765 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_RS04780 ENOG4105CMT Dihydroxyacetone kinase HBA75_RS04790 ENOG4105CMT Dihydroxyacetone kinase HBA75_RS04825 ENOG41069ER domain protein HBA75_RS04855 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HBA75_RS04895 ENOG4105WN5 stage II sporulation protein HBA75_RS04905 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS04915 ENOG4108MJI response regulator HBA75_RS04920 ENOG4105BZU Histidine kinase HBA75_RS04925 ENOG4105BZU Histidine kinase HBA75_RS04965 ENOG4107QHE Choloylglycine hydrolase HBA75_RS04985 ENOG4107VRP DNA repair exonuclease HBA75_RS04990 ENOG4106D4I domain protein HBA75_RS05005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_RS05060 ENOG4108MUZ hydrolase HBA75_RS05090 ENOG4105F0F Oxalate decarboxylase HBA75_RS05100 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HBA75_RS05120 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HBA75_RS05135 ENOG4105DU6 RNA polymerase HBA75_RS05150 ENOG4105EEM helicase HBA75_RS05160 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_RS05185 ENOG4105K59 histidine triad (HIT) protein HBA75_RS05220 ENOG410905X membrane-flanked domain protein HBA75_RS05225 ENOG4105CKV Membrane HBA75_RS05270 ENOG410905X membrane-flanked domain protein HBA75_RS05275 ENOG4105CKV Membrane HBA75_RS05280 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HBA75_RS05285 ENOG4105BZ4 penicillin-binding protein HBA75_RS05295 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HBA75_RS05300 ENOG4105C1Q protoporphyrinogen oxidase HBA75_RS05325 ENOG4105NA0 Transcriptional regulator HBA75_RS05340 ENOG4105ECB domain protein HBA75_RS05385 ENOG4106AXD HBA75_RS05390 ENOG4108RQ5 Beta-lactamase domain-containing protein HBA75_RS05395 ENOG4105DF9 Lipoate-protein, ligase HBA75_RS05405 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS05415 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HBA75_RS05420 ENOG4108I5D sulfate abc transporter HBA75_RS05425 ENOG4105ECW sulfate abc transporter HBA75_RS05430 ENOG4108IJ6 ABC transporter HBA75_RS05470 ENOG4107RN3 metallophosphoesterase HBA75_RS05475 ENOG4107TVP HD domain protein HBA75_RS05485 ENOG4108AEY RNA polymerase sigma factor HBA75_RS05490 ENOG41086D8 Transcriptional regulator HBA75_RS05495 ENOG41085W3 Transposase HBA75_RS05510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS05530 ENOG410836F Transposase HBA75_RS05535 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HBA75_RS05540 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS05545 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HBA75_RS05555 ENOG4107QP3 malate synthase g HBA75_RS05620 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HBA75_RS05665 ENOG4105ERH Fumarylacetoacetate hydrolase HBA75_RS05675 ENOG4105C8Y Acetylornithine aminotransferase HBA75_RS05690 ENOG4105CAQ asparagine synthetase HBA75_RS05695 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HBA75_RS05700 ENOG4105CH6 catalase HBA75_RS05705 ENOG4105BZU Histidine kinase HBA75_RS05725 ENOG4105QNR S1 RNA binding domain protein HBA75_RS05730 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_RS05740 ENOG4107AYK membrAne HBA75_RS05750 ENOG41073B9 HBA75_RS05760 ENOG4108KP7 hydrolase HBA75_RS05770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HBA75_RS05795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HBA75_RS05800 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HBA75_RS05820 ENOG4105C31 Tryptophanyl-tRNA synthetase HBA75_RS05845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HBA75_RS05850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HBA75_RS05860 ENOG4108JQ7 (ABC) transporter HBA75_RS05865 ENOG4105UQX Mate efflux family protein HBA75_RS05885 ENOG4108ZCF integral membrane protein HBA75_RS05895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_RS05905 ENOG4105DPN Oligoendopeptidase f HBA75_RS05920 ENOG4108Z18 K06886 hemoglobin HBA75_RS05925 ENOG4105MIX Adenylate cyclase HBA75_RS05940 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HBA75_RS05945 ENOG4105EMS pseudouridine synthase HBA75_RS05965 ENOG4105K64 Glycosyl transferase, family 2 HBA75_RS05985 ENOG4107TVC Glycosyl transferase, family 2 HBA75_RS06005 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HBA75_RS06010 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HBA75_RS06020 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HBA75_RS06100 ENOG4105CK7 Sodium proline symporter HBA75_RS06110 ENOG4105DDQ anthranilate synthase HBA75_RS06200 ENOG4105C7S Dehydrogenase HBA75_RS06205 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HBA75_RS06210 ENOG4105VZ8 Transcriptional regulator HBA75_RS06270 ENOG4105DZ1 carboxypeptidase HBA75_RS06275 ENOG4105VFR signal peptidase HBA75_RS06310 ENOG4105C26 Dehydrogenase HBA75_RS06315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS06320 ENOG4105F38 ABC transporter, permease HBA75_RS06325 ENOG4105D38 putrescine abc transporter HBA75_RS06330 ENOG4108HM4 ABC transporter HBA75_RS06340 ENOG4105EYF MMPL domain protein HBA75_RS06350 ENOG4108YBP pseudouridine synthase HBA75_RS06360 ENOG4105K4I Scp-like extracellular HBA75_RS06365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HBA75_RS06370 ENOG4105CQB FAD linked oxidase domain protein HBA75_RS06385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS06390 ENOG4105BZU Histidine kinase HBA75_RS06395 ENOG4105JXH GntR family transcriptional regulator HBA75_RS06415 ENOG4106A3R peptidase HBA75_RS06425 ENOG4108QTI )-transporter HBA75_RS06430 ENOG4107TS3 membrane protein, TerC HBA75_RS06435 ENOG4105CZN Potassium uptake protein HBA75_RS06440 ENOG410681C small acid-soluble spore protein HBA75_RS06445 ENOG4108Z7G MaoC domain protein dehydratase HBA75_RS06465 ENOG4105CHR reductase HBA75_RS06495 ENOG4105C4Y ABC transporter HBA75_RS06500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS06505 ENOG4107RCV ABC transporter, permease HBA75_RS06525 ENOG4105E98 transcriptional regulator DeoR family HBA75_RS06535 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HBA75_RS06545 ENOG4105PXI polysaccharide deacetylase HBA75_RS06555 ENOG4105BZU Histidine kinase HBA75_RS06560 ENOG41090MY MarR family Transcriptional regulator HBA75_RS06570 ENOG4106DF1 HBA75_RS06575 ENOG4105BZU Histidine kinase HBA75_RS06580 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HBA75_RS06585 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HBA75_RS06590 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HBA75_RS06630 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HBA75_RS06635 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBA75_RS06640 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBA75_RS06645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS06650 ENOG4105CZV ABC transporter HBA75_RS06660 ENOG4105CJ1 ABC, transporter HBA75_RS06700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HBA75_RS06705 ENOG4105EA8 2-Nitropropane dioxygenase HBA75_RS06710 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HBA75_RS06720 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HBA75_RS06745 ENOG4105NQC Flavodoxin HBA75_RS06785 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_RS06815 ENOG4105CZN Potassium uptake protein HBA75_RS06820 ENOG41063Y9 HBA75_RS06825 ENOG4105KBJ sporulation protein ytfj HBA75_RS06845 ENOG4105CM2 brancheD-chain amino acid aminotransferase HBA75_RS06850 ENOG4105C7K acetolactate synthase HBA75_RS06855 ENOG4108ZP8 Acetolactate synthase small subunit HBA75_RS06860 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HBA75_RS06875 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HBA75_RS06895 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HBA75_RS06900 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HBA75_RS06925 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HBA75_RS06930 ENOG4107RVV histidinol phosphate phosphatase, hisj family HBA75_RS06945 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_RS06950 ENOG4105E0M Sulfatase HBA75_RS06960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HBA75_RS06975 ENOG4107S4M Sulfate adenylate transferase HBA75_RS06980 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HBA75_RS06985 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HBA75_RS06995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HBA75_RS07000 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HBA75_RS07005 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HBA75_RS07010 ENOG4105C8J )-transporter HBA75_RS07035 ENOG4105DFD Na H antiporter HBA75_RS07055 ENOG4105ENE Histidine kinase HBA75_RS07060 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_RS07080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HBA75_RS07120 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HBA75_RS07145 ENOG4105CJ3 phosphate transporter HBA75_RS07150 ENOG4107GRR phosphate transport regulator HBA75_RS07155 ENOG4105BZ4 penicillin-binding protein HBA75_RS07170 ENOG4105BZU Histidine kinase HBA75_RS07175 ENOG4105I3N Conserved Protein HBA75_RS07190 ENOG4105BZU Histidine kinase HBA75_RS07220 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_RS07225 ENOG4105DZ1 carboxypeptidase HBA75_RS07230 ENOG4108JIC nucleoside recognition domain protein HBA75_RS07240 ENOG4105FE9 pseudouridine synthase HBA75_RS07245 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_RS07250 ENOG4107TWT Cytochrome c biogenesis protein HBA75_RS07255 ENOG4105CRE cytochrome C HBA75_RS07260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS07265 ENOG4105BZU Histidine kinase HBA75_RS07270 ENOG4108WBT adenosyltransferase HBA75_RS07290 ENOG4108SAX Membrane HBA75_RS07305 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_RS07310 ENOG4105I7S Abortive infection protein HBA75_RS07325 ENOG4108XDN Transcriptional regulator HBA75_RS07330 ENOG4108S6Z Negative regulator of genetic competence HBA75_RS07355 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HBA75_RS07360 ENOG4107RB3 L-asparaginase HBA75_RS07380 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HBA75_RS07395 ENOG4105S2F HBA75_RS07400 ENOG41065D1 HBA75_RS07430 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HBA75_RS07445 ENOG4105XXQ heptaprenyl diphosphate synthase component I HBA75_RS07455 ENOG4105EAH synthase HBA75_RS07460 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HBA75_RS07470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HBA75_RS07485 ENOG41068YB TPR repeat-containing protein HBA75_RS07500 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HBA75_RS07505 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HBA75_RS07540 ENOG4108JYZ YitT family HBA75_RS07545 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HBA75_RS07560 ENOG4105FJR Lmbe family HBA75_RS07565 ENOG4105CPK Glycosyl transferase (Group 1 HBA75_RS07585 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HBA75_RS07600 ENOG4105DVT helicase HBA75_RS07605 ENOG4105YAC HBA75_RS07625 ENOG4105CSM endonuclease III HBA75_RS07635 ENOG4105BZ4 penicillin-binding protein HBA75_RS07690 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HBA75_RS07730 ENOG4105DVT helicase HBA75_RS07735 ENOG4105CTD carboxy-peptidase HBA75_RS07745 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_RS07750 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HBA75_RS07755 ENOG4105C2W permease HBA75_RS07760 ENOG4105DHF Membrane HBA75_RS07770 ENOG410890F Dynamin family HBA75_RS07780 ENOG4108W0I acetyltransferase HBA75_RS07790 ENOG4105KHC sulfurtransferase HBA75_RS07815 ENOG4106032 Glutathionylspermidine synthase HBA75_RS07845 ENOG4105HTX biosynthesis protein HBA75_RS07875 ENOG4105CPK Glycosyl transferase (Group 1 HBA75_RS07890 ENOG4108SZE gCN5-related N-acetyltransferase HBA75_RS07910 ENOG41081VK Ribonuclease HBA75_RS07985 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_RS07995 ENOG4107RWR Sodium hydrogen exchanger HBA75_RS08000 ENOG4105CN5 Metallo-Beta-Lactamase HBA75_RS08005 ENOG4108Z5V transcriptional regulator, merr family HBA75_RS08015 ENOG4105H67 Protein of unknown function (DUF421) HBA75_RS08020 ENOG41080C8 DUF218 domain HBA75_RS08060 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HBA75_RS08070 ENOG4107R0U MotA TolQ exbB proton channel HBA75_RS08075 ENOG4105ER2 Ompa motb domain protein HBA75_RS08080 ENOG4107YTP response regulator receiver protein HBA75_RS08085 ENOG4105CBS Chea signal transduction histidine kinase HBA75_RS08090 ENOG4105DD5 Flagellar motor switch protein HBA75_RS08105 ENOG4105BZU Histidine kinase HBA75_RS08125 ENOG4105E1Q flagellar hook-associated protein HBA75_RS08130 ENOG4105DTJ flagellar hook-associated protein HBA75_RS08135 ENOG4107TPX flagellar hook-associated HBA75_RS08150 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HBA75_RS08155 ENOG4108ZC9 flagellar basal-body rod protein flgc HBA75_RS08165 ENOG4107U2N Flagellar M-ring protein HBA75_RS08170 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HBA75_RS08200 ENOG4105BZE flagellar hook protein, FlgE HBA75_RS08215 ENOG4107R88 Chemotaxis protein (CheV) HBA75_RS08225 ENOG4105I03 Flagellin HBA75_RS08230 ENOG4105I03 Flagellin HBA75_RS08235 ENOG4105I03 Flagellin HBA75_RS08240 ENOG4105I03 Flagellin HBA75_RS08245 ENOG4105E4C Lytic transglycosylase catalytic HBA75_RS08255 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HBA75_RS08260 ENOG4105DD5 Flagellar motor switch protein HBA75_RS08270 ENOG4105CN7 Flagellar biosynthetic protein FliP HBA75_RS08275 ENOG4105VS8 Flagellar biosynthetic protein fliq HBA75_RS08285 ENOG4105D00 flagellar biosynthetic protein flhB HBA75_RS08290 ENOG4105D7B Flagellar biosynthesis protein flha HBA75_RS08295 ENOG4105FZW flagellar biosynthesis regulator FlhF HBA75_RS08300 ENOG4105KTQ flagellar basal-body rod protein HBA75_RS08305 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_RS08350 ENOG4105KAC Antibiotic biosynthesis monooxygenase HBA75_RS08390 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HBA75_RS08395 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HBA75_RS08430 ENOG4105CVJ phosphoglycerate mutase HBA75_RS08440 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HBA75_RS08460 ENOG4105CAQ asparagine synthetase HBA75_RS08480 ENOG4105PGM cation diffusion facilitator family transporter HBA75_RS08490 ENOG4105DRR Transcriptional regulator, GntR family HBA75_RS08495 ENOG4108UZ3 Transporter HBA75_RS08505 ENOG4105CKI cobalamin synthesis protein HBA75_RS08510 ENOG4108PJD permease HBA75_RS08525 ENOG4105DFD Na H antiporter HBA75_RS08530 ENOG4105VUF Transcriptional regulator HBA75_RS08540 ENOG4105C9Q fumarate hydratase class II HBA75_RS08560 ENOG4107QJQ Mate efflux family protein HBA75_RS08565 ENOG4105EC3 peptidase S51, dipeptidase E HBA75_RS08585 ENOG4107QIV Cytochrome c biogenesis protein HBA75_RS08590 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_RS08610 ENOG4106BRA Membrane HBA75_RS08645 ENOG4105CJ1 ABC, transporter HBA75_RS08670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HBA75_RS08680 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_RS08685 ENOG4105DQ6 Transposase HBA75_RS08700 ENOG4105C6K Malic enzyme HBA75_RS08755 ENOG4105FVX HBA75_RS08760 ENOG4105E09 nadh pyrophosphatase HBA75_RS08775 ENOG4105CSR polyphosphate kinase 2 HBA75_RS08780 ENOG4105U3E Transcriptional regulator HBA75_RS08795 ENOG4105DXI Major Facilitator superfamily HBA75_RS08810 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HBA75_RS08830 ENOG4105C6T cysteine synthase HBA75_RS08850 ENOG4105C8J )-transporter HBA75_RS08860 ENOG4105X5K response regulator receiver protein HBA75_RS08865 ENOG4105H67 Protein of unknown function (DUF421) HBA75_RS08885 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HBA75_RS08890 ENOG4105CHR reductase HBA75_RS08895 ENOG4105CM2 brancheD-chain amino acid aminotransferase HBA75_RS08900 ENOG4105C7K acetolactate synthase HBA75_RS08910 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HBA75_RS08920 ENOG4105C7B Threonine dehydratase HBA75_RS08940 ENOG4105C6X Major Facilitator HBA75_RS08945 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HBA75_RS08955 ENOG4105DY9 regulatoR HBA75_RS08960 ENOG4105CYC Transferase HBA75_RS08965 ENOG4105K5X acetyltransferase HBA75_RS08985 ENOG41068WN HBA75_RS09005 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HBA75_RS09020 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HBA75_RS09025 ENOG4105C0X amino acid HBA75_RS09070 ENOG410849A acetyltransferase, (GNAT) family HBA75_RS09130 ENOG4107RHR regulatoR HBA75_RS09140 ENOG4105D9N nucleoside HBA75_RS09145 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HBA75_RS09175 ENOG410811B TRANSCRIPTIONal HBA75_RS09190 ENOG4107RAQ aminopeptidase HBA75_RS09200 ENOG4107R16 Multicopper oxidase HBA75_RS09215 ENOG4105MKU Transcriptional regulator HBA75_RS09275 ENOG4105W8Z 4'-phosphopantetheinyl transferase HBA75_RS09315 ENOG4108T5E Copper resistance protein HBA75_RS09320 ENOG4105KTB nuclear export factor GLE1 HBA75_RS09340 ENOG4105GZI Transcriptional regulator HBA75_RS09345 ENOG4108Z40 Transcriptional regulator HBA75_RS09355 ENOG4108TVJ Nitroreductase HBA75_RS09365 ENOG4106F5Q Membrane HBA75_RS09370 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_RS09380 ENOG4105CKI cobalamin synthesis protein HBA75_RS09390 ENOG4105C0Z ABC transporter HBA75_RS09395 ENOG4108IV0 ABC, transporter HBA75_RS09400 ENOG4105C32 Amino acid ABC transporter (Permease) HBA75_RS09410 ENOG4105SKE transcriptional Regulator LysR family HBA75_RS09440 ENOG4105C4M (Ubiquinol oxidase) subunit I HBA75_RS09445 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBA75_RS09455 ENOG4108JJ8 (ABC) transporter HBA75_RS09465 ENOG4105K64 Glycosyl transferase, family 2 HBA75_RS09475 ENOG4108UT6 Transferase hexapeptide repeat containing protein HBA75_RS09530 ENOG4105BZ1 (ABC) transporter HBA75_RS09535 ENOG4105EFI regulatoR HBA75_RS09540 ENOG4105BZU Histidine kinase HBA75_RS09555 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HBA75_RS09580 ENOG41085W3 Transposase HBA75_RS09585 ENOG4105D6E homoserine dehydrogenase HBA75_RS09610 ENOG4108KGH TRANSCRIPTIONal HBA75_RS09620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS09625 ENOG4105BZU Histidine kinase HBA75_RS09640 ENOG4105KT7 mgtC SapB transporter HBA75_RS09645 ENOG4105VRR gCN5-related N-acetyltransferase HBA75_RS09655 ENOG4105DUU IucA IucC family protein HBA75_RS09660 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS09675 ENOG4108WBH protein TIM barrel HBA75_RS09680 ENOG4105YWU small acid-soluble spore protein HBA75_RS09690 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HBA75_RS09695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS09750 ENOG4105KRN Transcriptional regulator, abrb family HBA75_RS09760 ENOG4105YVS arsR family transcriptional regulator HBA75_RS09765 ENOG4105CPC Aldo Keto reductase HBA75_RS09770 ENOG4107XZQ multidrug resistance protein HBA75_RS09795 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS09810 ENOG4108K88 Membrane HBA75_RS09815 ENOG4108WPJ Ferritin-like domain HBA75_RS09830 ENOG4105DEN Luciferase family HBA75_RS09845 ENOG4105VMI -acetyltransferase HBA75_RS09850 ENOG4107QM2 Aldo Keto reductase HBA75_RS09860 ENOG4105CKI cobalamin synthesis protein HBA75_RS09870 ENOG4105DSE periplasmic solute binding protein HBA75_RS09885 ENOG4105K4T epimerase HBA75_RS09895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBA75_RS09940 ENOG4107T5V SNARE associated Golgi HBA75_RS09955 ENOG4108PJD permease HBA75_RS09965 ENOG4108S4H thioesterase Superfamily protein HBA75_RS09975 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_RS09995 ENOG4105SXS Protein of unknown function (DUF456) HBA75_RS10000 ENOG4105C37 (CBS) domain HBA75_RS10020 ENOG4108Z7R Chaperone CsaA HBA75_RS10040 ENOG4108ZRV stage ii sporulation protein p HBA75_RS10050 ENOG4108VXD carboxy-peptidase HBA75_RS10075 ENOG4108ZRV stage ii sporulation protein p HBA75_RS10085 ENOG4108X4Q Hydrolase HBA75_RS10100 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HBA75_RS10115 ENOG41087PP glycosyltransferase MGT family HBA75_RS10120 ENOG4108JYZ YitT family HBA75_RS10125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS10155 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HBA75_RS10190 ENOG4108MGT Required for secretion of EsxA and EsxB HBA75_RS10270 ENOG4105KBJ sporulation protein ytfj HBA75_RS10275 ENOG4105DQ6 Transposase HBA75_RS10305 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HBA75_RS10325 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HBA75_RS10330 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HBA75_RS10340 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HBA75_RS10360 ENOG4105CNW domain protein HBA75_RS10370 ENOG4108V06 Glutathione peroxidase HBA75_RS10385 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_RS10395 ENOG4108IUE nitrate reductase beta subunit HBA75_RS10400 ENOG4105R3A Nitrate reductase HBA75_RS10410 ENOG4107V6Q Cyclic nucleotide-binding domain HBA75_RS10415 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_RS10420 ENOG4105D06 uba thif-type nad fad binding protein HBA75_RS10425 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_RS10430 ENOG4108ZAF Molybdopterin HBA75_RS10460 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HBA75_RS10465 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HBA75_RS10470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HBA75_RS10475 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HBA75_RS10480 ENOG4108IFG nitrite reductase, (NAD(P)H) HBA75_RS10535 ENOG4105MCT stage V sporulation protein S HBA75_RS10580 ENOG4105C5H ABC transporter HBA75_RS10595 ENOG4108UUM single-stranded DNA-binding protein HBA75_RS10630 ENOG4107YX5 Pfam:DUF548 HBA75_RS10635 ENOG4105C75 arginyL-tRNA synthetase HBA75_RS10660 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HBA75_RS10670 ENOG410836F Transposase HBA75_RS10695 ENOG4105C5S asparaginyl-tRNA synthetase HBA75_RS10700 ENOG4105C8J )-transporter HBA75_RS10720 ENOG4107XGZ Hydrolase HBA75_RS10725 ENOG4105CY2 Citrate transporter HBA75_RS10745 ENOG4105KD7 acetyltransferase HBA75_RS10755 ENOG4105VMP Transcriptional regulator HBA75_RS10760 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HBA75_RS10785 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HBA75_RS10800 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HBA75_RS10805 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HBA75_RS10815 ENOG4107RVG penicillin-binding protein HBA75_RS10820 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HBA75_RS10825 ENOG4105E9Q Acyl-transferase HBA75_RS10830 ENOG4108UT2 hemolysin iii HBA75_RS10840 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HBA75_RS10850 ENOG4108RCR degv family HBA75_RS10860 ENOG4108KF3 Electron transport protein SCO1 SenC HBA75_RS10865 ENOG4107Y70 Heat shock protein HBA75_RS10870 ENOG4105CAQ asparagine synthetase HBA75_RS10890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HBA75_RS10895 ENOG4108MES Periplasmic binding protein HBA75_RS10900 ENOG4105F0I Aminotransferase HBA75_RS10945 ENOG4105D8X mechanosensitive ion channel HBA75_RS10950 ENOG4105BZU Histidine kinase HBA75_RS10955 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_RS10960 ENOG4106KNT transcriptional regulator HBA75_RS10995 ENOG4105CMG Carbohydrate kinase HBA75_RS11000 ENOG4105C6Z Gluconate HBA75_RS11010 ENOG4108YV3 Protein of unknown function (DUF2711) HBA75_RS11040 ENOG4108IJ8 ABC transporter HBA75_RS11045 ENOG4105E90 ABC transporter HBA75_RS11080 ENOG4105C37 (CBS) domain HBA75_RS11105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_RS11120 ENOG4107S4Y M20 DapE family protein YgeY HBA75_RS11125 ENOG4108TSC N-acetyltransferase HBA75_RS11130 ENOG4108JUB Transcriptional regulator HBA75_RS11140 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HBA75_RS11185 ENOG410841Q phosphoesterase PA-phosphatase related protein HBA75_RS11195 ENOG4105SZ6 Thioredoxin HBA75_RS11240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_RS11295 ENOG4105BZ4 penicillin-binding protein HBA75_RS11305 ENOG4105CZM Major Facilitator HBA75_RS11310 ENOG4105W8X HesB YadR YfhF-family protein HBA75_RS11320 ENOG4105DXD 2-methylcitrate dehydratase HBA75_RS11325 ENOG4105CR4 methylisocitrate lyase HBA75_RS11330 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS11335 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBA75_RS11345 ENOG4105N14 lysine exporter protein LysE YggA HBA75_RS11350 ENOG4105E39 Enoyl-CoA hydratase HBA75_RS11365 ENOG4107RFY SbcCD D subunit HBA75_RS11370 ENOG4105EYH Exonuclease HBA75_RS11400 ENOG4105FCD Major Facilitator HBA75_RS11405 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HBA75_RS11410 ENOG4105E4F Isochorismate synthase HBA75_RS11415 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HBA75_RS11420 ENOG4105WQI isochorismatase HBA75_RS11425 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS11430 ENOG4105WQT MbtH domain protein HBA75_RS11435 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_RS11450 ENOG4105K70 DNA-binding protein HBA75_RS11470 ENOG4105BZG amino acid carrier protein HBA75_RS11490 ENOG4105FE9 pseudouridine synthase HBA75_RS11495 ENOG4105C22 threonyL-tRNA synthetase HBA75_RS11500 ENOG4105C19 ABC transporter HBA75_RS11560 ENOG41081I9 integral membrane protein HBA75_RS11570 ENOG4108Y4K DNA-binding transcriptional activator HBA75_RS11590 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HBA75_RS11600 ENOG4105EYF MMPL domain protein HBA75_RS11625 ENOG4105WCN acetyltransferase HBA75_RS11650 ENOG4105C1Q protoporphyrinogen oxidase HBA75_RS11660 ENOG41068WN HBA75_RS11690 ENOG4107V2S Transcriptional regulator HBA75_RS11695 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HBA75_RS11715 ENOG4105DND Transcriptional regulator HBA75_RS11720 ENOG4108RPX mosc domain containing protein HBA75_RS11735 ENOG4105BZ1 (ABC) transporter HBA75_RS11770 ENOG4108JCI Transcriptional regulator HBA75_RS11800 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HBA75_RS11805 ENOG4108KPJ rna polymerase sigma factor HBA75_RS11830 ENOG4105F32 YngK protein HBA75_RS11850 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HBA75_RS11855 ENOG4105RD7 BadF BadG BcrA BcrD HBA75_RS11860 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HBA75_RS11865 ENOG4107STF Involved in phosphonate degradation (By similarity) HBA75_RS11875 ENOG4108INS Transcriptional regulator HBA75_RS11890 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HBA75_RS11900 ENOG4105C1J atp-dependent rna helicase HBA75_RS11920 ENOG4105KRN Transcriptional regulator, abrb family HBA75_RS11985 ENOG41088CC tellurite resistance protein tehB HBA75_RS11995 ENOG4108I0C methyltransferase HBA75_RS12000 ENOG4107RA9 decarboxylase HBA75_RS12005 ENOG41090HR transcriptional regulator HBA75_RS12010 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HBA75_RS12035 ENOG4105CIN aminoacyl-histidine dipeptidase HBA75_RS12065 ENOG4105KRN Transcriptional regulator, abrb family HBA75_RS12080 ENOG4105EJ9 Membrane HBA75_RS12085 ENOG4105EQK -acetyltransferase HBA75_RS12125 ENOG41085W3 Transposase HBA75_RS12140 ENOG4105W8Z 4'-phosphopantetheinyl transferase HBA75_RS12185 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS12270 ENOG4105FQP Beta-lactamase HBA75_RS12275 ENOG4107RVG penicillin-binding protein HBA75_RS12290 ENOG4107RF6 penicillin-binding protein HBA75_RS12295 ENOG4107RF6 penicillin-binding protein HBA75_RS12305 ENOG4105DIN metallophosphoesterase HBA75_RS12315 ENOG4105CJ1 ABC, transporter HBA75_RS12325 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_RS12340 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS12345 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBA75_RS12350 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HBA75_RS12355 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HBA75_RS12360 ENOG4105E39 Enoyl-CoA hydratase HBA75_RS12365 ENOG4107QX3 carboxylase HBA75_RS12370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HBA75_RS12380 ENOG41085W3 Transposase HBA75_RS12395 ENOG4105DBI uridine monophosphokinase HBA75_RS12410 ENOG4105DZ1 carboxypeptidase HBA75_RS12435 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HBA75_RS12455 ENOG41075H3 AraC family transcriptional regulator HBA75_RS12500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HBA75_RS12540 ENOG4107Y80 Major Facilitator superfamily HBA75_RS12545 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HBA75_RS12550 ENOG4105KVH Transcriptional regulator HBA75_RS12615 ENOG4105EFA 4-hydroxyphenylacetate HBA75_RS12630 ENOG4105CPQ Dehydrogenase HBA75_RS12640 ENOG410900G Protein of unknown function (DUF421) HBA75_RS12655 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HBA75_RS12665 ENOG4105DK7 lysyl-tRNA synthetase HBA75_RS12675 ENOG4108VQT Alpha beta hydrolase fold protein HBA75_RS12775 ENOG4105CPF Cell wall formation (By similarity) HBA75_RS12780 ENOG4105ETU transcriptional activator (TenA HBA75_RS12875 ENOG410667J hydrolase HBA75_RS12880 ENOG4105BZU Histidine kinase HBA75_RS12885 ENOG4107RF6 penicillin-binding protein HBA75_RS12910 ENOG4108JJB ABC transporter HBA75_RS12925 ENOG4108HGU Histidine kinase HBA75_RS12940 ENOG4105CB2 alcohol dehydrogenase HBA75_RS12945 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HBA75_RS12950 ENOG4105CJN penicillin-binding protein HBA75_RS13010 ENOG4107STQ Multicopper oxidase HBA75_RS13020 ENOG4107TXC Transcriptional regulator HBA75_RS13040 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HBA75_RS13060 ENOG4105DQ6 Transposase HBA75_RS13080 ENOG4107Y9U Membrane HBA75_RS13125 ENOG4105FCD Major Facilitator HBA75_RS13135 ENOG4105E09 nadh pyrophosphatase HBA75_RS13140 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBA75_RS13160 ENOG4108XI2 Domain of unknown function (DUF1963) HBA75_RS13180 ENOG4108NRW Phospholipase, patatin family HBA75_RS13185 ENOG4105KWG Pfam:DUF1696 HBA75_RS13210 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_RS13220 ENOG4105PKS Excinuclease abc c subunit domain protein HBA75_RS13270 ENOG4107VFR oxidoreductase HBA75_RS13310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS13315 ENOG4105BZU Histidine kinase HBA75_RS13335 ENOG4107WD8 ABC transporter, permease HBA75_RS13350 ENOG4105DQ6 Transposase HBA75_RS13370 ENOG4105DY8 decarboxylase HBA75_RS13395 ENOG4105CGH 5'-nucleotidase HBA75_RS13410 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HBA75_RS13415 ENOG4105FDR Membrane HBA75_RS13475 ENOG4105MSI germination protein ypeb HBA75_RS13525 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HBA75_RS13530 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HBA75_RS13535 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_RS13560 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HBA75_RS13580 ENOG4105E98 transcriptional regulator DeoR family HBA75_RS13595 ENOG41062ES Transcriptional regulator HBA75_RS13615 ENOG4107QKR Dehydrogenase HBA75_RS13625 ENOG4107RUY (E1 component), alpha subunit HBA75_RS13635 ENOG4105E1F short-chain dehydrogenase reductase HBA75_RS13640 ENOG4105RHY Pfam:UPF0157 HBA75_RS13680 ENOG4107SQ8 Glycine betaine HBA75_RS13685 ENOG4108IJ7 Glycine betaine HBA75_RS13695 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HBA75_RS13710 ENOG4105E66 phosphoriboisomerase A HBA75_RS13715 ENOG41082BV acetyltransferase HBA75_RS13720 ENOG4108M1A Chitin-binding protein HBA75_RS13750 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_RS13755 ENOG4105MSB protein, conserved in bacteria HBA75_RS13780 ENOG4108Z7F N-acetyltransferase HBA75_RS13800 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HBA75_RS13805 ENOG4105EEM helicase HBA75_RS13820 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_RS13860 ENOG4105DQ6 Transposase HBA75_RS13890 ENOG4108M1A Chitin-binding protein HBA75_RS13905 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HBA75_RS13915 ENOG4105BZG amino acid carrier protein HBA75_RS13920 ENOG4105C26 Dehydrogenase HBA75_RS13925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBA75_RS13930 ENOG4105CTU Proline racemase HBA75_RS13935 ENOG4105CTU Proline racemase HBA75_RS13940 ENOG41080HI glycine oxidase HBA75_RS13950 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HBA75_RS13985 ENOG4107T5V SNARE associated Golgi HBA75_RS13995 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HBA75_RS14020 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_RS14035 ENOG4107SET aldo keto reductase HBA75_RS14070 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HBA75_RS14075 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_RS14080 ENOG4105BZU Histidine kinase HBA75_RS14085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS14105 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HBA75_RS14120 ENOG4105DPN Oligoendopeptidase f HBA75_RS14125 ENOG4105EPR degv family HBA75_RS14185 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HBA75_RS14190 ENOG4106K7D Major facilitator family transporter HBA75_RS14210 ENOG4107BMA Transglycosylase associated protein HBA75_RS14225 ENOG41089UC methyltransferase, type 11 HBA75_RS14260 ENOG4105CHM Aminotransferase HBA75_RS14275 ENOG4108ZMI UPF0477 protein HBA75_RS14315 ENOG4105C02 permease HBA75_RS14325 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HBA75_RS14330 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HBA75_RS14335 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HBA75_RS14340 ENOG4105D7T ABC transporter HBA75_RS14375 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HBA75_RS14420 ENOG4107VC0 DNA alkylation repair enzyme HBA75_RS14425 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_RS14445 ENOG4108ZCF integral membrane protein HBA75_RS14450 ENOG4105E0M Sulfatase HBA75_RS14455 ENOG4105C5H ABC transporter HBA75_RS14460 ENOG4105EYF MMPL domain protein HBA75_RS14465 ENOG41082JN Transcriptional regulator HBA75_RS14475 ENOG410836F Transposase HBA75_RS14495 ENOG4105CIH Imidazole acetol-phosphate transaminase HBA75_RS14500 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HBA75_RS14505 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HBA75_RS14525 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HBA75_RS14550 ENOG41069ER domain protein HBA75_RS14560 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_RS14565 ENOG4105DNP FAD linked oxidase domain protein HBA75_RS14595 ENOG4105D4B ABC, transporter HBA75_RS14600 ENOG4105F5R ABC transporter HBA75_RS14605 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HBA75_RS14615 ENOG4105DKT Transcriptional regulator HBA75_RS14620 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HBA75_RS14630 ENOG41061GT Aldolase HBA75_RS14640 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HBA75_RS14675 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_RS14685 ENOG4107258 Transcriptional regulator HBA75_RS14740 ENOG4107RBI VanW family HBA75_RS14745 ENOG4105G6Z alkaline phosphatase HBA75_RS14755 ENOG4105VMP Transcriptional regulator HBA75_RS14780 ENOG41068WN HBA75_RS14810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_RS14825 ENOG4105CSH Transporter HBA75_RS14835 ENOG4105CKK Glycosyl transferase, family 2 HBA75_RS14865 ENOG4105C8Y Acetylornithine aminotransferase HBA75_RS14915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_RS14960 ENOG4108IBT Inherit from COG: transposase HBA75_RS14980 ENOG4108TVJ Nitroreductase HBA75_RS14985 ENOG4105FS7 Transcriptional regulator HBA75_RS15005 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HBA75_RS15010 ENOG4105WEC Molybdate metabolism regulator HBA75_RS15020 ENOG4105CMR udp-glucose 4-epimerase HBA75_RS15030 ENOG4108DMH HTH_ARAC HBA75_RS15035 ENOG4108XET gCN5-related N-acetyltransferase HBA75_RS15050 ENOG4108PCN EamA-like transporter family HBA75_RS15095 ENOG410635A Membrane HBA75_RS15110 ENOG4108IQI permease HBA75_RS15120 ENOG4105F1N DNA alkylation repair HBA75_RS15150 ENOG4107RF6 penicillin-binding protein HBA75_RS15155 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HBA75_RS15175 ENOG410836F Transposase HBA75_RS15180 ENOG4105E7W lamb ycsf family protein HBA75_RS15190 ENOG4105P4J Allophanate hydrolase, subunit 1 HBA75_RS15195 ENOG4107258 Transcriptional regulator HBA75_RS15205 ENOG4106N3A copper homeostasis protein cutc HBA75_RS15210 ENOG4108ZHR arsR family transcriptional regulator HBA75_RS15225 ENOG4105FDT acyl-CoA dehydrogenase HBA75_RS15245 ENOG4105DQ6 Transposase HBA75_RS15260 ENOG4105DQ6 Transposase HBA75_RS15265 ENOG4105DWD nucleoside recognition domain protein HBA75_RS15305 ENOG4105DQ6 Transposase HBA75_RS15325 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HBA75_RS15330 ENOG41087PP glycosyltransferase MGT family HBA75_RS15385 ENOG4105E2A Dehydrogenase HBA75_RS15395 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_RS15400 ENOG4105HDK L-asparaginase HBA75_RS15405 ENOG4108IMY Transcriptional regulator HBA75_RS15440 ENOG4108B31 Spore germination protein HBA75_RS15450 ENOG4105BZU Histidine kinase HBA75_RS15475 ENOG41075H3 AraC family transcriptional regulator HBA75_RS15485 ENOG4105YWU small acid-soluble spore protein HBA75_RS15490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HBA75_RS15495 ENOG4105CUB amino acid HBA75_RS15500 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_RS15510 ENOG4105C6K Malic enzyme HBA75_RS15535 ENOG4108NHD germination protein HBA75_RS15540 ENOG4108Q8B Spore germination protein HBA75_RS15560 ENOG4105CSV Glutaminase HBA75_RS15575 ENOG4106A3M Cytochrome p-450 HBA75_RS15590 ENOG4108IG5 Transcriptional regulator HBA75_RS15595 ENOG4105F27 Major Facilitator HBA75_RS15600 ENOG4105M4P Tetr family transcriptional regulator HBA75_RS15610 ENOG4108YXU transcriptional regulator AsnC family HBA75_RS15650 ENOG4105N0V mono-oxygenase ydhR HBA75_RS15675 ENOG41085W3 Transposase HBA75_RS15725 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HBA75_RS15730 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_RS15740 ENOG4105K6H D-cysteine desulfhydrase HBA75_RS15750 ENOG4105E0Y RtcB Protein HBA75_RS15760 ENOG4105JQZ Methyltransferase HBA75_RS15785 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HBA75_RS15805 ENOG4105BZU Histidine kinase HBA75_RS15820 ENOG4108U05 Transcriptional regulator HBA75_RS15825 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HBA75_RS15835 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HBA75_RS15870 ENOG4108JQ1 Dehydrogenase HBA75_RS15875 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HBA75_RS15915 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_RS16020 ENOG4108VXD carboxy-peptidase HBA75_RS16025 ENOG4105PNM synthesis protein HBA75_RS16035 ENOG4108ISG Major Facilitator HBA75_RS16050 ENOG4107MII Sugar-specific transcriptional regulator TrmB HBA75_RS16055 ENOG4105CZM Major Facilitator HBA75_RS16070 ENOG4105DA5 (ABC) transporter HBA75_RS16075 ENOG41069JR HBA75_RS16090 ENOG4105CRW Short chain fatty acid transporter HBA75_RS16100 ENOG4105DYS nad(p)h dehydrogenase (quinone) HBA75_RS16160 ENOG4108K8S endonuclease I HBA75_RS16170 ENOG4105CUT histidyl-tRNA synthetase HBA75_RS16185 ENOG4105KVH Transcriptional regulator HBA75_RS16190 ENOG4108RCM Nitroreductase HBA75_RS16200 ENOG4105CA9 Pyruvate kinase HBA75_RS16220 ENOG4108PSK reductase HBA75_RS16290 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HBA75_RS16325 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HBA75_RS16365 ENOG4105C37 (CBS) domain HBA75_RS16380 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HBA75_RS16385 ENOG4105FAW cDP-glucose 4,6-dehydratase HBA75_RS16415 ENOG4105DDN Pentapeptide repeat-containing protein HBA75_RS16420 ENOG4105XDF Protein of unknown function (DUF1272) HBA75_RS16425 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HBA75_RS16430 ENOG4105CMG Carbohydrate kinase HBA75_RS16435 ENOG4105C6Z Gluconate HBA75_RS16445 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HBA75_RS16455 ENOG4105CV1 Transketolase (EC 2.2.1.1) HBA75_RS16460 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HBA75_RS16465 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HBA75_RS16470 ENOG4105CIS alcohol dehydrogenase HBA75_RS16475 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HBA75_RS16485 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HBA75_RS16500 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS16505 ENOG4108UX3 '-nucleotidase HBA75_RS16510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HBA75_RS16515 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HBA75_RS16520 ENOG4105KVH Transcriptional regulator HBA75_RS16535 ENOG4105CV8 reductase HBA75_RS16540 ENOG4105F27 Major Facilitator HBA75_RS16550 ENOG41090KN UPF0303 protein HBA75_RS16565 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HBA75_RS16570 ENOG4105CHH sulfate transporter HBA75_RS16585 ENOG4105C44 Serine transporter HBA75_RS16610 ENOG41085W3 Transposase HBA75_RS16625 ENOG4105KVH Transcriptional regulator HBA75_RS16630 ENOG4108TZY GntR Family Transcriptional Regulator HBA75_RS16635 ENOG4105D9R oxidoreductase HBA75_RS16640 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HBA75_RS16645 ENOG4105KVH Transcriptional regulator HBA75_RS16650 ENOG4105KVH Transcriptional regulator HBA75_RS16710 ENOG4105JAB phenazine biosynthesis protein, phzf family HBA75_RS16720 ENOG4105CHR reductase HBA75_RS16730 ENOG4105KNA -acetyltransferase HBA75_RS16745 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HBA75_RS16750 ENOG4105KVH Transcriptional regulator HBA75_RS16765 ENOG41085W3 Transposase HBA75_RS16770 ENOG4105DQ6 Transposase HBA75_RS16880 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HBA75_RS16890 ENOG4107YXZ hydrolase, family 25 HBA75_RS16920 ENOG4105H3G oxidoreductase HBA75_RS16990 ENOG4108TN2 lmbE family HBA75_RS17000 ENOG4107R3E Citrate transporter HBA75_RS17010 ENOG4105WCN acetyltransferase HBA75_RS17015 ENOG4108MES Periplasmic binding protein HBA75_RS17020 ENOG4105EHG Permease protein HBA75_RS17025 ENOG4105DQ5 transport system permease protein HBA75_RS17030 ENOG4105NX3 Membrane HBA75_RS17050 ENOG4105D9U N-acetyltransferase HBA75_RS17055 ENOG4107CUJ Protein of unknown function (DUF2690) HBA75_RS17065 ENOG4107V2S Transcriptional regulator HBA75_RS17085 ENOG4105C98 muts2 protein HBA75_RS17090 ENOG4105E5K Alpha-amylase HBA75_RS17095 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HBA75_RS17100 ENOG4105DPN Oligoendopeptidase f HBA75_RS17125 ENOG4105FFC UPF0187 protein HBA75_RS17140 ENOG4108A04 Beta-lactamase HBA75_RS17165 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HBA75_RS17175 ENOG41082BM Transcriptional regulator, arsr family HBA75_RS17180 ENOG4105CIS alcohol dehydrogenase HBA75_RS17185 ENOG4105CNG UPF0061 protein HBA75_RS17205 ENOG4105CQB FAD linked oxidase domain protein HBA75_RS17230 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_RS17235 ENOG4107TPS domain protein HBA75_RS17240 ENOG4105CEP NADH dehydrogenase HBA75_RS17250 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HBA75_RS17260 ENOG4108IAJ Nad-dependent epimerase dehydratase HBA75_RS17265 ENOG4105FAW cDP-glucose 4,6-dehydratase HBA75_RS17300 ENOG41067SE Tetr family transcriptional regulator HBA75_RS17315 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HBA75_RS17325 ENOG4107DUR UPF0457 protein HBA75_RS17345 ENOG4105BZU Histidine kinase HBA75_RS17355 ENOG4105KT7 mgtC SapB transporter HBA75_RS17365 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_RS17370 ENOG41073R8 VanW family HBA75_RS17380 ENOG4108R1P HBA75_RS17395 ENOG4105VEQ Cold shock protein HBA75_RS17415 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HBA75_RS17465 ENOG410904N short-chain dehydrogenase reductase HBA75_RS17475 ENOG4106IQC argininosuccinate lyase HBA75_RS17490 ENOG4108IA2 Sodium pantothenate symporter HBA75_RS17500 ENOG4105C26 Dehydrogenase HBA75_RS17505 ENOG4105CHR reductase HBA75_RS17515 ENOG4105EWU Squalene--hopene cyclase HBA75_RS17525 ENOG4105FR1 rard protein HBA75_RS17535 ENOG410696E Membrane HBA75_RS17550 ENOG4105D1F ATP-binding protein HBA75_RS17560 ENOG4108ZAF Molybdopterin HBA75_RS17565 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_RS17570 ENOG4105D06 uba thif-type nad fad binding protein HBA75_RS17575 ENOG4105TMB Formate nitrite transporter HBA75_RS17585 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HBA75_RS17590 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HBA75_RS17600 ENOG4108JB9 formate dehydrogenase HBA75_RS17605 ENOG4105E1K spore germination protein HBA75_RS17620 ENOG4105CUB amino acid HBA75_RS17675 ENOG4107QJT sodium dicarboxylate symporter HBA75_RS17680 ENOG4108KGH TRANSCRIPTIONal HBA75_RS17690 ENOG4105EMN RNA polymerase sigma factor HBA75_RS17705 ENOG4105CIG ABC transporter HBA75_RS17715 ENOG4105D9R oxidoreductase HBA75_RS17725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBA75_RS17730 ENOG4105K4P CoA-binding domain protein HBA75_RS17735 ENOG4105C0H protease HBA75_RS17740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS17750 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HBA75_RS17760 ENOG4105W8X HesB YadR YfhF-family protein HBA75_RS17795 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HBA75_RS17800 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_RS17810 ENOG4105BZ1 (ABC) transporter HBA75_RS17815 ENOG4108I0Z Aconitate hydratase HBA75_RS17845 ENOG4105E5W Transporter HBA75_RS17855 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_RS17875 ENOG4107F3J Amp-dependent synthetase and ligase HBA75_RS17880 ENOG4107ZYJ bioY protein HBA75_RS17885 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS17930 ENOG4107AYK membrAne HBA75_RS17940 ENOG4105BZU Histidine kinase HBA75_RS17945 ENOG4105FBA Phospholipase Carboxylesterase HBA75_RS17950 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HBA75_RS17955 ENOG4105CK7 Sodium proline symporter HBA75_RS17965 ENOG4105CBC glutamate synthase HBA75_RS17975 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS17985 ENOG4108VJ1 Transcriptional regulator (CarD family HBA75_RS17990 ENOG4108903 Formimidoylglutamase HBA75_RS18045 ENOG4107QIV Cytochrome c biogenesis protein HBA75_RS18080 ENOG4107RSM transcriptional regulator HBA75_RS18090 ENOG41067MG lrgb family HBA75_RS18130 ENOG4105BZ1 (ABC) transporter HBA75_RS18135 ENOG4105BZ1 (ABC) transporter HBA75_RS18185 ENOG4105CGH 5'-nucleotidase HBA75_RS18195 ENOG4108SVB resolvase HBA75_RS18215 ENOG4105K7K Transcriptional regulator HBA75_RS18225 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_RS18230 ENOG4105DR5 peptidase HBA75_RS18235 ENOG41065S2 pneumococcal vaccine antigen HBA75_RS18265 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HBA75_RS18270 ENOG4105C5F glutamine synthetase HBA75_RS18275 ENOG4105KV4 Transcriptional regulator HBA75_RS18280 ENOG4105CXI aluminum resistance protein HBA75_RS18285 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HBA75_RS18290 ENOG4105EN6 Membrane HBA75_RS18300 ENOG4106F1P AAA ATPase, central domain protein HBA75_RS18335 ENOG41069ER domain protein HBA75_RS18340 ENOG4105DM4 PTS System HBA75_RS18345 ENOG4105DE4 1-phosphofructokinase HBA75_RS18350 ENOG4105E98 transcriptional regulator DeoR family HBA75_RS18355 ENOG4107QW4 alcohol dehydrogenase HBA75_RS18360 ENOG4108SJC Membrane HBA75_RS18370 ENOG4105C85 amino acid HBA75_RS18385 ENOG4105TMB Formate nitrite transporter HBA75_RS18390 ENOG4105K70 DNA-binding protein HBA75_RS18400 ENOG4105C59 p-type ATPase HBA75_RS18405 ENOG410681U heavy metal transport detoxification protein HBA75_RS18410 ENOG4105VPX protein, conserved in bacteria HBA75_RS18420 ENOG4105NIV Esterase HBA75_RS18425 ENOG4105E0A ABC, transporter HBA75_RS18455 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBA75_RS18460 ENOG4105D03 DNA-3-methyladenine glycosylase II HBA75_RS18485 ENOG4105BZU Histidine kinase HBA75_RS18525 ENOG41067MG lrgb family HBA75_RS18540 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HBA75_RS18545 ENOG4107YEI lmbE family HBA75_RS18565 ENOG4105F0V Cell wall hydrolase HBA75_RS18575 ENOG4105E0M Sulfatase HBA75_RS18580 ENOG410890F Dynamin family HBA75_RS18615 ENOG4105DQU oxidoreductase, subunit beta HBA75_RS18620 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HBA75_RS18625 ENOG4108IGT Dipeptidase HBA75_RS18630 ENOG4105MCT stage V sporulation protein S HBA75_RS18635 ENOG4105D48 metallophosphoesterase HBA75_RS18655 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HBA75_RS18670 ENOG4105XZV Protein of unknown function (DUF3243) HBA75_RS18675 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HBA75_RS18695 ENOG4105UIB (ABC) transporter HBA75_RS18700 ENOG4108JQ9 ABC transporter HBA75_RS18705 ENOG4105DIH basic membrane HBA75_RS18710 ENOG4105FDP GntR family transcriptional regulator HBA75_RS18720 ENOG4105CNU cell division protein FtsK HBA75_RS18730 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HBA75_RS18740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBA75_RS18750 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HBA75_RS18755 ENOG4108S0H Dipicolinic acid synthetase, b subunit HBA75_RS18760 ENOG4105E35 Dipicolinate synthase subunit A HBA75_RS18770 ENOG4105C1V Peptidase, M16 HBA75_RS18790 ENOG4105DTN riboflavin biosynthesis protein ribF HBA75_RS18805 ENOG4105W7A Protein of unknown function (DUF503) HBA75_RS18815 ENOG4105VHM ribosomal protein HBA75_RS18820 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HBA75_RS18825 ENOG4105CHV Transcription elongation factor NusA HBA75_RS18835 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HBA75_RS18845 ENOG4105DZP Membrane-associated zinc metalloprotease HBA75_RS18850 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HBA75_RS18855 ENOG4105KNE Phosphatidate cytidylyltransferase HBA75_RS18860 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HBA75_RS18870 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HBA75_RS18900 ENOG4108HE4 integrase family HBA75_RS18910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HBA75_RS18915 ENOG4105C79 DNA protecting protein DprA HBA75_RS18920 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HBA75_RS18935 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HBA75_RS18960 ENOG4105VB6 UPF0109 protein HBA75_RS18980 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HBA75_RS18985 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HBA75_RS19000 ENOG4105CHR reductase HBA75_RS19005 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HBA75_RS19020 ENOG4105CB5 ATP-dependent DNA helicase recG HBA75_RS19025 ENOG4105DP4 dak2 domain fusion protein ylov HBA75_RS19030 ENOG4108ZAA Alkaline-shock protein HBA75_RS19045 ENOG4105FJ0 thiamine HBA75_RS19050 ENOG4105DJV ribulose-phosphate 3-epimerase HBA75_RS19055 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HBA75_RS19060 ENOG4105D9P serine threonine protein kinase HBA75_RS19065 ENOG4108ZF3 Phosphatase HBA75_RS19075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HBA75_RS19090 ENOG4105C25 Primosomal protein n' HBA75_RS19095 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HBA75_RS19115 ENOG4105DSJ YicC domain protein HBA75_RS19130 ENOG4105DC7 peptidase M24 HBA75_RS19155 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HBA75_RS19170 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HBA75_RS19175 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HBA75_RS19185 ENOG4105CD3 dihydroorotase HBA75_RS19205 ENOG4105C34 Pseudouridine synthase HBA75_RS19230 ENOG4105DBK s4 domain protein HBA75_RS19235 ENOG41067XK integral membrane protein HBA75_RS19245 ENOG4105DFA alanine racemase domain protein HBA75_RS19250 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HBA75_RS19255 ENOG4105WR5 sporulation protein, YlmC YmxH family HBA75_RS19265 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS19275 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HBA75_RS19280 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HBA75_RS19290 ENOG4105D4A Cell wall formation (By similarity) HBA75_RS19295 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HBA75_RS19300 ENOG4105CNI cell division protein FtsW HBA75_RS19315 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HBA75_RS19320 ENOG4105CJN penicillin-binding protein HBA75_RS19325 ENOG4105CJN penicillin-binding protein HBA75_RS19340 ENOG41074B2 UPF0747 protein HBA75_RS19365 ENOG4105KNH Nucleic acid-binding protein HBA75_RS19375 ENOG41063PX domain protein HBA75_RS19380 ENOG4105D78 K07001 NTE family protein HBA75_RS19385 ENOG4105H20 Sporulation integral membrane protein YlbJ HBA75_RS19395 ENOG4106H78 methyltransferase HBA75_RS19415 ENOG4107TB6 phosphoglycerate mutase HBA75_RS19430 ENOG4106UY4 Inherit from COG: Scp-like extracellular HBA75_RS19480 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HBA75_RS19485 ENOG4105CNI cell division protein FtsW HBA75_RS19500 ENOG4108IAB Phoh family HBA75_RS19520 ENOG4105QA2 HBA75_RS19525 ENOG4105CI3 gtp-binding protein typa HBA75_RS19535 ENOG4105ECY inositol monophosphatase HBA75_RS19555 ENOG4105CXN decarboxylase HBA75_RS19605 ENOG4105CPP Dehydrogenase, E1 component HBA75_RS19620 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HBA75_RS19625 ENOG4108X4Q Hydrolase HBA75_RS19635 ENOG4105CN5 Metallo-Beta-Lactamase HBA75_RS19640 ENOG4107ZYR domain protein HBA75_RS19675 ENOG4108XRC Protein of unknown function (DUF458) HBA75_RS19685 ENOG4107IN1 Protein of unknown function (DUF1797) HBA75_RS19700 ENOG4105EPM Diguanylate phosphodiesterase HBA75_RS19705 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HBA75_RS19720 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HBA75_RS19730 ENOG4105UIN HBA75_RS19765 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HBA75_RS19785 ENOG4108HGU Histidine kinase HBA75_RS19795 ENOG4105CHM Aminotransferase HBA75_RS19800 ENOG4105FKQ transcriptional regulator HBA75_RS19805 ENOG4105EG2 ABC transporter, permease HBA75_RS19815 ENOG4107FKK extracellular solute-binding protein family 1 HBA75_RS19825 ENOG4105CG3 alpha amylase, catalytic region HBA75_RS19875 ENOG4105CHU acetyl-coa acetyltransferase HBA75_RS19910 ENOG4105K7K Transcriptional regulator HBA75_RS19915 ENOG4105DTD Dehydrogenase HBA75_RS19945 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HBA75_RS19970 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HBA75_RS19985 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBA75_RS19995 ENOG4105BZU Histidine kinase HBA75_RS20015 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HBA75_RS20030 ENOG4105CID antiterminator HBA75_RS20050 ENOG4105CE4 GlcNAc 6-P deacetylase HBA75_RS20085 ENOG4107ZE5 PPIases accelerate the folding of proteins HBA75_RS20090 ENOG4105PTM secreted protein HBA75_RS20095 ENOG4105DQ6 Transposase HBA75_RS20105 ENOG4105J7I hydrolase HBA75_RS20115 ENOG4105G6R Stage v sporulation protein ae HBA75_RS20140 ENOG41090VF Stage v sporulation protein ac HBA75_RS20160 ENOG4105C8J )-transporter HBA75_RS20165 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS20175 ENOG41082AN stage II sporulation protein HBA75_RS20180 ENOG4105DZ1 carboxypeptidase HBA75_RS20185 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS20190 ENOG4105DVE abc transporter atp-binding protein HBA75_RS20225 ENOG4105D7N magnesium and cobalt transport protein CorA HBA75_RS20250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_RS20260 ENOG4105I3K Ferric uptake regulator, Fur family HBA75_RS20265 ENOG4105MZ9 stage II sporulation protein m HBA75_RS20285 ENOG4105CPC Aldo Keto reductase HBA75_RS20295 ENOG4105RHY Pfam:UPF0157 HBA75_RS20315 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HBA75_RS20325 ENOG4105ETE Transcriptional regulator (LacI family HBA75_RS20330 ENOG4108YM7 Gcn5-related n-acetyltransferase HBA75_RS20350 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HBA75_RS20355 ENOG4108R6K riboflavin synthase, subunit alpha HBA75_RS20380 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_RS20385 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_RS20395 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HBA75_RS20400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_RS20410 ENOG4105DFD Na H antiporter HBA75_RS20415 ENOG4105CGH 5'-nucleotidase HBA75_RS20440 ENOG4105DBV ornithine carbamoyltransferase HBA75_RS20455 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HBA75_RS20470 ENOG4108IXY short-chain dehydrogenase reductase HBA75_RS20475 ENOG41069FQ Metallo-beta-lactamase superfamily HBA75_RS20480 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_RS20485 ENOG4105EJQ L-serine dehydratase HBA75_RS20500 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HBA75_RS20520 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HBA75_RS20535 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HBA75_RS20540 ENOG4105D9U N-acetyltransferase HBA75_RS20555 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HBA75_RS20560 ENOG4108QEG Membrane HBA75_RS20565 ENOG4105CDA abc transporter atp-binding protein HBA75_RS20570 ENOG4105E5Q amino acid AbC transporter HBA75_RS20575 ENOG4108HW3 (ABC) transporter HBA75_RS20585 ENOG4105G7B Protein of unknown function (DUF2992) HBA75_RS20590 ENOG4105E09 nadh pyrophosphatase HBA75_RS20595 ENOG4108QY0 Membrane HBA75_RS20605 ENOG4105C7S Dehydrogenase HBA75_RS20610 ENOG4105CPP Dehydrogenase, E1 component HBA75_RS20625 ENOG4105CKM Branched-chain carboxylic acid kinase HBA75_RS20630 ENOG4107RDP Dehydrogenase HBA75_RS20640 ENOG4108JUB Transcriptional regulator HBA75_RS20650 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HBA75_RS20670 ENOG4107QQR Sporulation HBA75_RS20675 ENOG4105S1Z Stage IV sporulation protein B HBA75_RS20680 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HBA75_RS20695 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HBA75_RS20705 ENOG4105DX0 Hemolysin A HBA75_RS20715 ENOG4105CTB Polyprenyl synthetase HBA75_RS20730 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HBA75_RS20740 ENOG4108ZSR alkaline shock protein HBA75_RS20745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBA75_RS20770 ENOG410644B Stage III sporulation protein af HBA75_RS20780 ENOG4105KQ4 Stage iii sporulation protein ad HBA75_RS20785 ENOG4108CQH stage III sporulation protein AC HBA75_RS20790 ENOG4105KR5 Stage iii sporulation protein HBA75_RS20795 ENOG4105CD2 stage iii sporulation protein aa HBA75_RS20820 ENOG4105DC7 peptidase M24 HBA75_RS20825 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HBA75_RS20840 ENOG4105CBJ Metal-dependent enzyme HBA75_RS20850 ENOG4107YBY Hydrolase HBA75_RS20865 ENOG4105K7K Transcriptional regulator HBA75_RS20880 ENOG41082GG biotin lipoate A B protein ligase HBA75_RS20885 ENOG4105WZW rhodanese family HBA75_RS20910 ENOG41080TC multidrug resistance protein HBA75_RS20945 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS20975 ENOG4105C0D helicase HBA75_RS21095 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HBA75_RS21100 ENOG4105C3R Methionine synthase HBA75_RS21110 ENOG4105C28 cystathionine HBA75_RS21115 ENOG4105C28 cystathionine HBA75_RS21140 ENOG4105C5X domain protein HBA75_RS21150 ENOG4105DKQ ROK family HBA75_RS21160 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HBA75_RS21175 ENOG4108UTW Plays a role in the regulation of phosphate uptake HBA75_RS21180 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS21185 ENOG4105C8U phosphate abc transporter HBA75_RS21190 ENOG4105C8U phosphate abc transporter HBA75_RS21195 ENOG4105EXS phosphate abc transporter HBA75_RS21200 ENOG4107RF6 penicillin-binding protein HBA75_RS21210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_RS21235 ENOG4105N80 Ferric uptake regulator, Fur family HBA75_RS21245 ENOG4105FDK ABC transporter HBA75_RS21250 ENOG4108JYZ YitT family HBA75_RS21255 ENOG41069ZM Protein of unknown function (DUF2624) HBA75_RS21280 ENOG4105EGD dinuclear metal center protein, YbgI family HBA75_RS21295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS21300 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HBA75_RS21330 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HBA75_RS21335 ENOG4105KG3 cytidine deaminase HBA75_RS21340 ENOG4107YR5 Diacylglycerol kinase HBA75_RS21345 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HBA75_RS21350 ENOG4105CTJ Metal Dependent Phosphohydrolase HBA75_RS21355 ENOG4105C9A Phoh family HBA75_RS21365 ENOG41068P3 sporulation protein YqfC HBA75_RS21375 ENOG4105KTH gatB Yqey HBA75_RS21385 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HBA75_RS21390 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HBA75_RS21420 ENOG4105CSA Coproporphyrinogen iii oxidase HBA75_RS21425 ENOG4105KVH Transcriptional regulator HBA75_RS21435 ENOG4105DQ6 Transposase HBA75_RS21460 ENOG4105TQK DNA polymerase iii, delta' subunit HBA75_RS21475 ENOG4108UK2 deaminase HBA75_RS21480 ENOG4105KQC Competence protein HBA75_RS21490 ENOG4105DXX methyltransferase HBA75_RS21500 ENOG4108WF2 Metal Dependent Phosphohydrolase HBA75_RS21510 ENOG410812S Rna-binding protein HBA75_RS21520 ENOG4105CQW ribosome biogenesis GTPase YqeH HBA75_RS21525 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HBA75_RS21540 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS21560 ENOG4108TVJ Nitroreductase HBA75_RS21575 ENOG4105G6Z alkaline phosphatase HBA75_RS21580 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HBA75_RS21585 ENOG4108MUZ hydrolase HBA75_RS21620 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HBA75_RS21635 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_RS21675 ENOG4105S6R Iron-hydroxamate transporter permease subunit HBA75_RS21680 ENOG4108V5C ABC transporter HBA75_RS21690 ENOG4105C0A alcohol dehydrogenase HBA75_RS21695 ENOG4105C28 cystathionine HBA75_RS21735 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HBA75_RS21745 ENOG4105CFP Peptidase U32 HBA75_RS21750 ENOG4105XYU peptidase (U32 family) HBA75_RS21760 ENOG4105HHA aminodeoxychorismate lyase HBA75_RS21780 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_RS21790 ENOG4105C02 permease HBA75_RS21805 ENOG41060CR HBA75_RS21810 ENOG4105C7H Helicase, RecD TraA family HBA75_RS21820 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HBA75_RS21825 ENOG4105C3J Cysteine desulfurase HBA75_RS21835 ENOG4105D1H recombination factor protein RarA HBA75_RS21840 ENOG4108VCI transcription factor, rsfa family HBA75_RS21845 ENOG4105CUZ uba thif-type nad fad binding protein HBA75_RS21855 ENOG4105CUT histidyl-tRNA synthetase HBA75_RS21865 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HBA75_RS21870 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HBA75_RS21880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HBA75_RS21885 ENOG41076HS cation diffusion facilitator family transporter HBA75_RS21890 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HBA75_RS21900 ENOG4105CKP Polysaccharide Biosynthesis Protein HBA75_RS21905 ENOG4108QG2 Membrane HBA75_RS21920 ENOG4105VIE preprotein translocase, subunit YajC HBA75_RS21935 ENOG41061AI Protein of unknown function (DUF2905) HBA75_RS21950 ENOG4108HUF Transporter HBA75_RS21985 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HBA75_RS21990 ENOG4108IYU L-aspartate oxidase HBA75_RS22005 ENOG4108RPX mosc domain containing protein HBA75_RS22010 ENOG4105CQC Prephenate dehydratase HBA75_RS22025 ENOG4105C19 ABC transporter HBA75_RS22030 ENOG4105EWM Histidine kinase HBA75_RS22040 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HBA75_RS22055 ENOG4105X36 (ribosomal) protein HBA75_RS22065 ENOG4105C03 ribonuclease HBA75_RS22080 ENOG4107QMS site-determining protein HBA75_RS22100 ENOG4105DFF Rod shape-determining protein mreb HBA75_RS22130 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_RS22135 ENOG4105XSJ toxin secretion phage lysis holin HBA75_RS22255 ENOG41085W3 Transposase HBA75_RS22280 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HBA75_RS22305 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS22375 ENOG4106050 phage regulatory protein, rha family HBA75_RS22395 ENOG4107Y5K Resolvase HBA75_RS22415 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HBA75_RS22420 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HBA75_RS22430 ENOG41068KH stage VI sporulation protein D HBA75_RS22440 ENOG4105D52 delta-aminolevulinic acid dehydratase HBA75_RS22465 ENOG4105K56 Transcriptional regulator HBA75_RS22490 ENOG4108IUQ atp-dependent protease HBA75_RS22515 ENOG4108QCI YvbH-like oligomerisation region HBA75_RS22535 ENOG4105M59 Phosphodiesterase, mj0936 family HBA75_RS22540 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HBA75_RS22550 ENOG4108XJQ germination protein HBA75_RS22560 ENOG4108PCX Major Facilitator HBA75_RS22570 ENOG4105KBX Transcriptional regulator, TetR family HBA75_RS22580 ENOG4105PFC Transcriptional regulator HBA75_RS22590 ENOG4105DZC cytosine deaminase HBA75_RS22595 ENOG41067S9 phage shock protein C, PspC HBA75_RS22600 ENOG4108JCI Transcriptional regulator HBA75_RS22610 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HBA75_RS22615 ENOG4108Z40 Transcriptional regulator HBA75_RS22620 ENOG4105RHA ABC transporter, permease HBA75_RS22625 ENOG4108IUX (ABC) transporter HBA75_RS22630 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HBA75_RS22635 ENOG4105ER2 Ompa motb domain protein HBA75_RS22640 ENOG4105E14 MotA TolQ exbB proton channel HBA75_RS22645 ENOG4108VXD carboxy-peptidase HBA75_RS22655 ENOG4105E33 succinate dehydrogenase HBA75_RS22665 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HBA75_RS22675 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HBA75_RS22680 ENOG4105K63 Thioredoxin HBA75_RS22685 ENOG4105C10 Electron transfer flavoprotein HBA75_RS22690 ENOG4105BZJ Electron transfer flavoprotein HBA75_RS22695 ENOG41060WC Enoyl-CoA hydratase HBA75_RS22700 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_RS22705 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS22715 ENOG4105J76 Periplasmic binding protein HBA75_RS22720 ENOG4105S6R Iron-hydroxamate transporter permease subunit HBA75_RS22770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS22785 ENOG4105DR4 Methyltransferase HBA75_RS22795 ENOG4105KFN sortase, SrtB family HBA75_RS22800 ENOG4105E0A ABC, transporter HBA75_RS22815 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HBA75_RS22825 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HBA75_RS22835 ENOG4105FE9 pseudouridine synthase HBA75_RS22845 ENOG4105DCG PHP domain protein HBA75_RS22860 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HBA75_RS22875 ENOG4105C5S asparaginyl-tRNA synthetase HBA75_RS22880 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HBA75_RS22890 ENOG4108RWN rrna methyltransferase HBA75_RS22915 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_RS22920 ENOG4105CW7 secretion protein, HlyD family HBA75_RS22925 ENOG4108JGH Tetr family transcriptional regulator HBA75_RS22930 ENOG4105CN9 Peptidase m42 family protein HBA75_RS22950 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HBA75_RS22955 ENOG4105DQ6 Transposase HBA75_RS22965 ENOG4105C22 threonyL-tRNA synthetase HBA75_RS22970 ENOG4108TDW sporulation protein YtxC HBA75_RS23000 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HBA75_RS23005 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HBA75_RS23015 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HBA75_RS23020 ENOG4105C2M dna polymerase I HBA75_RS23025 ENOG4105BZU Histidine kinase HBA75_RS23030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS23040 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_RS23045 ENOG4108HMX isocitrate dehydrogenase (NADP) HBA75_RS23050 ENOG4105BZN citrate synthase HBA75_RS23060 ENOG4108REF Sporulation integral membrane protein ytvi HBA75_RS23065 ENOG4105FS0 cytoplasmic membrane protein HBA75_RS23090 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS23095 ENOG4105C6K Malic enzyme HBA75_RS23100 ENOG4105C0B DNA polymerase III (alpha subunit) HBA75_RS23105 ENOG4105VV2 HBA75_RS23115 ENOG4105SFS phosphoesterase RecJ domain protein HBA75_RS23145 ENOG4105DC7 peptidase M24 HBA75_RS23170 ENOG410836F Transposase HBA75_RS23180 ENOG4105Z7P Acetyltransferase (GNAT) family HBA75_RS23185 ENOG41082W1 Cupin 2, conserved barrel domain protein HBA75_RS23205 ENOG4107YZX Universal stress protein HBA75_RS23245 ENOG4108JYZ YitT family HBA75_RS23265 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HBA75_RS23275 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HBA75_RS23280 ENOG4105KBJ sporulation protein ytfj HBA75_RS23295 ENOG4105EFZ amidohydrolase HBA75_RS23305 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HBA75_RS23350 ENOG4105U5Y Transcriptional regulator HBA75_RS23360 ENOG4105C28 cystathionine HBA75_RS23390 ENOG4108UW5 maltose o-acetyltransferase HBA75_RS23400 ENOG4105F1V Acetoin utilization protein HBA75_RS23405 ENOG4105W87 Cbs domain HBA75_RS23410 ENOG4105DGU Histone deacetylase HBA75_RS23425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_RS23435 ENOG4107SNB ankyrin repeat protein YahD HBA75_RS23440 ENOG4105EP9 oxidoreductase HBA75_RS23470 ENOG4105ETE Transcriptional regulator (LacI family HBA75_RS23475 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HBA75_RS23495 ENOG4105C88 aminopeptidase HBA75_RS23530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HBA75_RS23540 ENOG4108VDD TRNA binding domain protein HBA75_RS23570 ENOG4105C8F Beta-lactamase domain protein HBA75_RS23590 ENOG4108V15 phosphotransferase enzyme family HBA75_RS23600 ENOG4108IUM Glycogen debranching enzyme HBA75_RS23610 ENOG4107QSE Dipeptidase HBA75_RS23615 ENOG4105YW5 deoR family transcriptional regulator HBA75_RS23630 ENOG4105CBX hi0933 family HBA75_RS23675 ENOG4108VJ1 Transcriptional regulator (CarD family HBA75_RS23680 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HBA75_RS23685 ENOG4105CSC Glucose uptake protein HBA75_RS23700 ENOG4108ZAF Molybdopterin HBA75_RS23705 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HBA75_RS23710 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_RS23720 ENOG4105D06 uba thif-type nad fad binding protein HBA75_RS23725 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_RS23745 ENOG41085GJ domain protein HBA75_RS23755 ENOG4105DWV Homoserine O-trans-acetylase HBA75_RS23765 ENOG4108B31 Spore germination protein HBA75_RS23795 ENOG4105C8T Leucyl-tRNA synthetase HBA75_RS23805 ENOG4107S91 Sodium hydrogen exchanger HBA75_RS23810 ENOG4105NCW Trka-c domain protein HBA75_RS23825 ENOG4105C19 ABC transporter HBA75_RS23845 ENOG4105N5T Radical SAM Protein HBA75_RS23870 ENOG4105E8V Alpha Beta Hydrolase Fold protein HBA75_RS23875 ENOG4108Z0R Transferase HBA75_RS23880 ENOG4105YVM Phosphoesterase, PA-phosphatase related HBA75_RS23885 ENOG4105BZF Glycosyl transferase (Group 1 HBA75_RS23895 ENOG4105EPU Molybdenum cofactor synthesis domain protein HBA75_RS23905 ENOG4108MK9 spermidine N(1)-acetyltransferase HBA75_RS23950 ENOG4105BZU Histidine kinase HBA75_RS23955 ENOG4105BZU Histidine kinase HBA75_RS23960 ENOG4105CH6 catalase HBA75_RS23970 ENOG4107S9D Alpha beta hydrolase HBA75_RS23975 ENOG4107T7U Sulfatase HBA75_RS24000 ENOG4105D2X ABC transporter substrate-binding protein HBA75_RS24010 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HBA75_RS24035 ENOG4105DQ6 Transposase HBA75_RS24090 ENOG4108V2W Carbonate dehydratase HBA75_RS24095 ENOG4105C4M (Ubiquinol oxidase) subunit I HBA75_RS24100 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBA75_RS24140 ENOG41087YS Phage shock protein A HBA75_RS24170 ENOG4105BZU Histidine kinase HBA75_RS24175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS24200 ENOG4108UGV hypoxanthine phosphoribosyltransferase HBA75_RS24205 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HBA75_RS24225 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS24270 ENOG4107ZTW SNARE associated Golgi HBA75_RS24285 ENOG4105C19 ABC transporter HBA75_RS24290 ENOG41086D8 Transcriptional regulator HBA75_RS24315 ENOG41082BM Transcriptional regulator, arsr family HBA75_RS24365 ENOG4105C6Z Gluconate HBA75_RS24390 ENOG41069H0 dihydroorotase EC 3.5.2.3 HBA75_RS24410 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_RS24415 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS24420 ENOG4108IPT Naphthoate synthase HBA75_RS24425 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HBA75_RS24430 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HBA75_RS24435 ENOG4105E4F Isochorismate synthase HBA75_RS24440 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HBA75_RS24450 ENOG4105VEQ Cold shock protein HBA75_RS24485 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HBA75_RS24500 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HBA75_RS24600 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HBA75_RS24635 ENOG4105KT7 mgtC SapB transporter HBA75_RS24640 ENOG4107PBV potassium channel HBA75_RS24655 ENOG4105WG9 Conserved Protein HBA75_RS24665 ENOG4105CHM Aminotransferase HBA75_RS24670 ENOG4108ZB6 transcriptional regulator AsnC family HBA75_RS24675 ENOG4105C5I Dehydrogenase HBA75_RS24680 ENOG4108MUZ hydrolase HBA75_RS24690 ENOG4105C87 Aminotransferase class I and II HBA75_RS24705 ENOG4105Y38 Kinase-associated protein B HBA75_RS24715 ENOG4107R3E Citrate transporter HBA75_RS24735 ENOG4105KA0 thioesterase Superfamily protein HBA75_RS24750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HBA75_RS24775 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HBA75_RS24780 ENOG4106YN8 Prenyltransferase HBA75_RS24790 ENOG41069ER domain protein HBA75_RS24805 ENOG4105CEP NADH dehydrogenase HBA75_RS24835 ENOG4105EWC Purine nucleoside phosphorylase HBA75_RS24890 ENOG4105XSJ toxin secretion phage lysis holin HBA75_RS25030 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS25055 ENOG4108ZUE Phage regulatory protein rha HBA75_RS25075 ENOG4108IMY Transcriptional regulator HBA75_RS25115 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HBA75_RS25140 ENOG4108JJA ABC, transporter HBA75_RS25145 ENOG4105C4B ABC transporter, permease HBA75_RS25150 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HBA75_RS25195 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS25230 ENOG41083MR nifu domain-containing protein HBA75_RS25245 ENOG4108W5N phosphatidylglycerophosphatase a HBA75_RS25265 ENOG4105DAX Pfam:DUF2983 HBA75_RS25275 ENOG4105DYS nad(p)h dehydrogenase (quinone) HBA75_RS25285 ENOG4105D4U had-superfamily hydrolase, subfamily iia HBA75_RS25300 ENOG4105CBT Fructose-1,6-bisphosphatase HBA75_RS25320 ENOG4105MMD transcriptional regulator HBA75_RS25325 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HBA75_RS25330 ENOG4107TXC Transcriptional regulator HBA75_RS25335 ENOG41090T1 Membrane HBA75_RS25360 ENOG4105FAA peptidase M23 HBA75_RS25365 ENOG4108YTE sporulation protein YunB HBA75_RS25370 ENOG4105KZD Domain of unknown function (DUF1805) HBA75_RS25375 ENOG4107R8B 5'-nucleotidase HBA75_RS25380 ENOG4105DIW FeS assembly protein SUFB HBA75_RS25385 ENOG4108UNV SUF system FeS assembly protein, NifU family HBA75_RS25390 ENOG4105C9B Cysteine desulfurase HBA75_RS25395 ENOG4105JRK feS assembly protein SufD HBA75_RS25400 ENOG4105C3K feS assembly ATPase SufC HBA75_RS25405 ENOG4105D01 (LipO)protein HBA75_RS25410 ENOG4105D01 (LipO)protein HBA75_RS25415 ENOG4108UMI ABC transporter, permease HBA75_RS25420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_RS25445 ENOG41080E8 Transcriptional regulator, Spx MgsR family HBA75_RS25465 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_RS25490 ENOG4108W8B Beta-lactamase domain protein HBA75_RS25495 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS25500 ENOG4105CHU acetyl-coa acetyltransferase HBA75_RS25515 ENOG4105DZ1 carboxypeptidase HBA75_RS25535 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HBA75_RS25550 ENOG4108SUT Major Facilitator Superfamily HBA75_RS25555 ENOG4107R7I amino acid HBA75_RS25570 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HBA75_RS25580 ENOG4107AYK membrAne HBA75_RS25615 ENOG4107ZTW SNARE associated Golgi HBA75_RS25625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HBA75_RS25630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS25635 ENOG4105BZU Histidine kinase HBA75_RS25650 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HBA75_RS25680 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS25685 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS25690 ENOG4105VG1 fes assembly suf system protein HBA75_RS25695 ENOG4105D4Y metalloprotease HBA75_RS25700 ENOG4105C2I pirin domain protein HBA75_RS25715 ENOG4107T5V SNARE associated Golgi HBA75_RS25720 ENOG4107S91 Sodium hydrogen exchanger HBA75_RS25725 ENOG4105NCW Trka-c domain protein HBA75_RS25735 ENOG4108RMU ferritin dps family protein HBA75_RS25750 ENOG4108URH decarboxylase HBA75_RS25760 ENOG41090A1 ferritin HBA75_RS25770 ENOG4105D9N nucleoside HBA75_RS25775 ENOG4105D9N nucleoside HBA75_RS25790 ENOG4108RYK Nad-dependent epimerase dehydratase HBA75_RS25805 ENOG4105CV8 reductase HBA75_RS25810 ENOG4105F27 Major Facilitator HBA75_RS25815 ENOG4105KVH Transcriptional regulator HBA75_RS25830 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HBA75_RS25835 ENOG4105D4A Cell wall formation (By similarity) HBA75_RS25855 ENOG4105WMR Protein CrcB homolog HBA75_RS25860 ENOG4105WMR Protein CrcB homolog HBA75_RS25875 ENOG4108MK9 spermidine N(1)-acetyltransferase HBA75_RS25890 ENOG4108W2Y isochorismatase HBA75_RS25920 ENOG4108IPW abc transporter atp-binding protein HBA75_RS25925 ENOG4105CM4 permease protein HBA75_RS25940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS25960 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HBA75_RS25965 ENOG410836F Transposase HBA75_RS25990 ENOG4105CNU cell division protein FtsK HBA75_RS26015 ENOG4105XSJ toxin secretion phage lysis holin HBA75_RS26025 ENOG410836F Transposase HBA75_RS26225 ENOG4106050 phage regulatory protein, rha family HBA75_RS26245 ENOG4108IMY Transcriptional regulator HBA75_RS26265 ENOG4105XZU Preprotein translocase, subunit SecG HBA75_RS26270 ENOG41067MG lrgb family HBA75_RS26320 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS26345 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_RS26350 ENOG4105XSJ toxin secretion phage lysis holin HBA75_RS26425 ENOG41085W3 Transposase HBA75_RS26495 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HBA75_RS26600 ENOG4106050 phage regulatory protein, rha family HBA75_RS26630 ENOG4105VTR Integrase HBA75_RS26685 ENOG4105KQC Competence protein HBA75_RS26695 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_RS26710 ENOG41090VF Stage v sporulation protein ac HBA75_RS26715 ENOG4105CZ3 stage V sporulation protein ad HBA75_RS26730 ENOG4108QY0 Membrane HBA75_RS26740 ENOG4105KRI phosphocarrier protein (HPr HBA75_RS26750 ENOG4105CHW UPF0052 protein HBA75_RS26760 ENOG4108Z4K mutator MutT protein HBA75_RS26770 ENOG4105C3M thioredoxin reductase HBA75_RS26780 ENOG4108S4C acetyltransferase HBA75_RS26800 ENOG41086DT Membrane protein of unknown function HBA75_RS26810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HBA75_RS26815 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HBA75_RS26830 ENOG4107TXC Transcriptional regulator HBA75_RS26850 ENOG4105DUM transcriptional regulator, lysR family HBA75_RS26860 ENOG4108WS4 fmn reductase HBA75_RS26865 ENOG4105C5H ABC transporter HBA75_RS26875 ENOG4105BZ1 (ABC) transporter HBA75_RS26885 ENOG4105CN1 protease HBA75_RS26890 ENOG4105CRP Part of the ABC transporter FtsEX involved in HBA75_RS26895 ENOG4105CAK Cell division ATP-binding protein ftsE HBA75_RS26915 ENOG4105MS2 ribosomal subunit Interface protein HBA75_RS26920 ENOG4105VEQ Cold shock protein HBA75_RS26925 ENOG41081UC Inherit from COG: Competence protein HBA75_RS26935 ENOG4105K4H Nlp p60 protein HBA75_RS26940 ENOG4105KVH Transcriptional regulator HBA75_RS26950 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HBA75_RS26955 ENOG4108KGH TRANSCRIPTIONal HBA75_RS26960 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HBA75_RS26965 ENOG4105C6Y Udp-glucose 6-dehydrogenase HBA75_RS26970 ENOG4105ESV Glycosyl transferase, family 4 HBA75_RS26980 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HBA75_RS27000 ENOG4105F8D glycoside hydrolase family 4 HBA75_RS27005 ENOG4105VCP PTS System HBA75_RS27010 ENOG4105CK1 PTS System HBA75_RS27020 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HBA75_RS27025 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HBA75_RS27030 ENOG4105VCP PTS System HBA75_RS27040 ENOG4105VZJ PTS System HBA75_RS27060 ENOG4105ECB domain protein HBA75_RS27065 ENOG4107RSM transcriptional regulator HBA75_RS27100 ENOG4105DAA L-lactate HBA75_RS27110 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HBA75_RS27120 ENOG4105E0M Sulfatase HBA75_RS27160 ENOG4105C94 Transporter HBA75_RS27165 ENOG41069ER domain protein HBA75_RS27200 ENOG4105KBK Zinc finger, swim domain protein HBA75_RS27205 ENOG4105C0D helicase HBA75_RS27215 ENOG41085W3 Transposase HBA75_RS27240 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_RS27250 ENOG4107RBB ABC transporter, permease HBA75_RS27255 ENOG4105C19 ABC transporter HBA75_RS27275 ENOG4105CXY transporter HBA75_RS27290 ENOG4105BZU Histidine kinase HBA75_RS27295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS27300 ENOG4105DG6 mannose-6-phosphate isomerase HBA75_RS27305 ENOG4105DM4 PTS System HBA75_RS27325 ENOG4108KGH TRANSCRIPTIONal HBA75_RS27330 ENOG4105DG6 mannose-6-phosphate isomerase HBA75_RS27355 ENOG4108TJN glycosyl transferase group 1 HBA75_RS27360 ENOG4105C6Y Udp-glucose 6-dehydrogenase HBA75_RS27365 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HBA75_RS27375 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HBA75_RS27380 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HBA75_RS27405 ENOG4105D3Q Sugar transferase HBA75_RS27410 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HBA75_RS27415 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HBA75_RS27420 ENOG4107YJ4 chain length determinant protein HBA75_RS27425 ENOG4105HTX biosynthesis protein HBA75_RS27430 ENOG4107YJ4 chain length determinant protein HBA75_RS27445 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HBA75_RS27455 ENOG4105FRN stage II sporulation protein HBA75_RS27470 ENOG4105DY9 regulatoR HBA75_RS27490 ENOG4106778 Protein of unknown function (DUF1146) HBA75_RS27495 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HBA75_RS27500 ENOG4105C8S subunit m HBA75_RS27505 ENOG4105D65 subunit l HBA75_RS27530 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HBA75_RS27535 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HBA75_RS27545 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HBA75_RS27550 ENOG4105BZU Histidine kinase HBA75_RS27600 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HBA75_RS27605 ENOG41062M3 atp synthase HBA75_RS27625 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HBA75_RS27630 ENOG4108UIC UPF0340 protein HBA75_RS27635 ENOG4108YZG isomerase HBA75_RS27650 ENOG4108VGI doxx family HBA75_RS27655 ENOG4107XC4 flavin reductase domain protein, FMN-binding HBA75_RS27670 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HBA75_RS27680 ENOG4108ZXQ stage ii sporulation protein r HBA75_RS27685 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HBA75_RS27690 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HBA75_RS27695 ENOG4107104 thymidine kinase HBA75_RS27705 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HBA75_RS27710 ENOG4105CBT Fructose-1,6-bisphosphatase HBA75_RS27715 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HBA75_RS27735 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HBA75_RS27750 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS27755 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS27760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBA75_RS27770 ENOG4105DF6 Fe-S oxidoreductase HBA75_RS27790 ENOG4105BZU Histidine kinase HBA75_RS27805 ENOG4105D4Y metalloprotease HBA75_RS27815 ENOG4105BZU Histidine kinase HBA75_RS27820 ENOG4105KCT ABC transporter HBA75_RS27825 ENOG4108M15 ABC transporter HBA75_RS27830 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_RS27840 ENOG4105IIU Aminopeptidase HBA75_RS27855 ENOG4105DU6 RNA polymerase HBA75_RS27865 ENOG410684U Domain of unknown function (DUF1934) HBA75_RS27885 ENOG4105CYW agmatinase HBA75_RS27895 ENOG4105DXB Major Facilitator superfamily HBA75_RS27900 ENOG4107SWG transcriptional regulator MERR family HBA75_RS27905 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HBA75_RS27910 ENOG4105BZ4 penicillin-binding protein HBA75_RS27915 ENOG4108XFG YwhD family HBA75_RS27920 ENOG4108Z4T Peptidase M50 HBA75_RS27925 ENOG41069HH 4-oxalocrotonate tautomerase HBA75_RS27930 ENOG4105DCI Phosphohydrolase HBA75_RS27935 ENOG4108MES Periplasmic binding protein HBA75_RS27940 ENOG4105E0A ABC, transporter HBA75_RS27945 ENOG4105EHG Permease protein HBA75_RS27950 ENOG4105DQ5 transport system permease protein HBA75_RS27960 ENOG4108VCI transcription factor, rsfa family HBA75_RS27965 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HBA75_RS27970 ENOG4108IJ2 phosphate acetyltransferase HBA75_RS27985 ENOG4108VKI Cell wall hydrolase HBA75_RS28010 ENOG4107SVH Potassium channel protein HBA75_RS28020 ENOG410667J hydrolase HBA75_RS28025 ENOG4105VCH membrane HBA75_RS28035 ENOG4108TU7 Inherit from COG: (ABC) transporter HBA75_RS28040 ENOG4105CJ1 ABC, transporter HBA75_RS28045 ENOG41090WU lipolytic protein G-D-S-L family HBA75_RS28060 ENOG4105D6E homoserine dehydrogenase HBA75_RS28085 ENOG4108Y4K DNA-binding transcriptional activator HBA75_RS28095 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_RS28100 ENOG4105BZU Histidine kinase HBA75_RS28105 ENOG4105DWF phosphomethylpyrimidine kinase HBA75_RS28110 ENOG4105BZU Histidine kinase HBA75_RS28115 ENOG4105VCD cytoplasmic protein HBA75_RS28120 ENOG4105D22 carbon starvation protein HBA75_RS28125 ENOG4105DY9 regulatoR HBA75_RS28130 ENOG41079KZ Major Facilitator Superfamily HBA75_RS28140 ENOG4105CG5 Glycosyl transferase (Group 1 HBA75_RS28150 ENOG4105EN6 Membrane HBA75_RS28155 ENOG4106YBV Methyl-accepting chemotaxis HBA75_RS28165 ENOG4108S4H thioesterase Superfamily protein HBA75_RS28170 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HBA75_RS28180 ENOG4105K64 Glycosyl transferase, family 2 HBA75_RS28200 ENOG4105CKK Glycosyl transferase, family 2 HBA75_RS28205 ENOG4105C5H ABC transporter HBA75_RS28210 ENOG41067SE Tetr family transcriptional regulator HBA75_RS28220 ENOG4105E0X reductase HBA75_RS28225 ENOG4106F5Q Membrane HBA75_RS28240 ENOG4108NEV two component transcriptional regulator, LytTR family HBA75_RS28245 ENOG4108HRK Histidine kinase HBA75_RS28250 ENOG4107RGD Major Facilitator superfamily HBA75_RS28265 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_RS28275 ENOG4105IW1 AmiS UreI transporter HBA75_RS28280 ENOG4105CMR udp-glucose 4-epimerase HBA75_RS28285 ENOG4108UT2 hemolysin iii HBA75_RS28295 ENOG4105C1J atp-dependent rna helicase HBA75_RS28300 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HBA75_RS28305 ENOG4105DPN Oligoendopeptidase f HBA75_RS28325 ENOG4105DQ6 Transposase HBA75_RS28340 ENOG4105BZU Histidine kinase HBA75_RS28345 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HBA75_RS28355 ENOG4105C0H protease HBA75_RS28360 ENOG4105Q2H domain protein HBA75_RS28375 ENOG4105BZU Histidine kinase HBA75_RS28380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS28405 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HBA75_RS28410 ENOG4105CDU Replicative dna helicase HBA75_RS28420 ENOG4105BZR domain protein HBA75_RS28425 ENOG4108XMW Membrane HBA75_RS28435 ENOG4108UUM single-stranded DNA-binding protein HBA75_RS28445 ENOG4105C3G gtp-binding protein HBA75_RS28450 ENOG4105VDK protein, conserved in bacteria HBA75_RS28455 ENOG4105D8X mechanosensitive ion channel HBA75_RS28460 ENOG4108ZDA Sporulation protein YyaC HBA75_RS28465 ENOG4105FA0 parb-like partition protein HBA75_RS28470 ENOG4107QJE Chromosome Partitioning Protein HBA75_RS28485 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HBA75_RS28490 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HBA75_RS28500 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HBA75_RS28515 ENOG4105C0W non-ribosomal peptide synthetase HBA75_RS28515 ENOG4105C0W non-ribosomal peptide synthetase HBA75_RS28535 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS28550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBA75_RS28555 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HBA75_RS28560 ENOG4105C1G acyl-Coa dehydrogenase HBA75_RS28570 ENOG4105C0W non-ribosomal peptide synthetase HBA75_RS28575 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HBA75_RS28580 ENOG4105IBP Cyclic peptide transporter HBA75_RS28625 ENOG4105TRI Hydrolase HBA75_RS28650 ENOG41067FT ParB-like nuclease domain HBA75_RS28670 ENOG4105BZ1 (ABC) transporter HBA75_RS28675 ENOG4105CJ1 ABC, transporter HBA75_RS28705 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_RS28760 ENOG4105CZV ABC transporter HBA75_RS28770 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_RS28775 ENOG4105BZ1 (ABC) transporter HBA75_RS28785 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HBA75_RS28825 ENOG4105DQ6 Transposase HBA75_RS28850 ENOG4108M1A Chitin-binding protein HBA75_RS28870 ENOG4105D7V transposase HBA75_RS28895 ENOG4105E1K spore germination protein HBA75_RS28905 ENOG4108M1A Chitin-binding protein HBA75_RS28910 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HBA75_RS28920 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_RS28945 ENOG4105BZU Histidine kinase HBA75_RS28950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_RS28960 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HBA75_RS28985 ENOG4107Y80 Major Facilitator superfamily HBA75_RS29010 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_RS29015 ENOG4108VGI doxx family HBA75_RS29035 ENOG4105DUX Transporter HBA75_RS29055 ENOG4105F6J Alpha beta hydrolase fold HBA75_RS29065 ENOG410836F Transposase HBA75_RS29110 ENOG4105CJ1 ABC, transporter HBA75_RS29145 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HBA75_RS29205 ENOG4105C19 ABC transporter HBA75_RS29295 ENOG4105DRR Transcriptional regulator, GntR family HBA75_RS29320 ENOG4107QHE Choloylglycine hydrolase HBA75_RS29345 ENOG4105MZU cell filamentation protein HBA75_RS29360 ENOG4105DVH amino acid HBA75_RS29380 ENOG4108UIN ybak prolyl-trna synthetase associated region HBA75_RS29395 ENOG4105JAB phenazine biosynthesis protein, phzf family HBA75_RS29405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_RS29430 ENOG4107XGZ Hydrolase HBA75_RS29435 ENOG4105E98 transcriptional regulator DeoR family HBA75_RS29440 ENOG4105D7V transposase HBA75_RS29610 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS29620 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS29635 ENOG4105EKQ RNA-directed DNA polymerase HBA75_RS29640 ENOG4105CNU cell division protein FtsK HBA75_RS29780 ENOG4107JM4 Tetratricopeptide repeat HBA75_RS29795 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HBA75_RS29800 ENOG4105M6F mutator MutT protein HBA75_RS29805 ENOG4108WZA zeta toxin HBA75_RS29845 ENOG4108V2W Carbonate dehydratase HBA75_RS29850 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HBA75_RS29880 ENOG4105KMT branched-chain amino acid HBA75_RS29885 ENOG4108UMN azlc family HBA75_RS29890 ENOG4107U9B transcriptional regulator HBA75_RS29925 ENOG41065S2 pneumococcal vaccine antigen HBA75_RS29930 ENOG4105DR5 peptidase HBA75_RS29935 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_RS29950 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_RS30035 ENOG4108TTB tellurium resistance protein HBA75_RS30040 ENOG4107TS3 membrane protein, TerC HBA75_RS30045 ENOG4106FN3 tellurium resistance protein HBA75_RS30050 ENOG4106FN3 tellurium resistance protein HBA75_RS30055 ENOG4108N0M stress protein HBA75_RS30060 ENOG41066F8 ROK family HBA75_RS30070 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HBA75_RS30085 ENOG4105DEU major facilitator superfamily HBA75_RS30100 ENOG41062JF Transcriptional regulator HBA75_RS30140 ENOG4105D2X ABC transporter substrate-binding protein HBA75_RS30145 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HBA75_RS30165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HBA75_RS30180 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_RS30195 ENOG4105CI1 PTS System HBA75_RS30205 ENOG4105DNP FAD linked oxidase domain protein HBA75_RS30220 ENOG4108W63 CRP FNR family transcriptional regulator HBA75_RS30225 ENOG4105C5B carbamate kinase HBA75_RS30235 ENOG4105DBV ornithine carbamoyltransferase HBA75_RS30255 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_RS30265 ENOG4105EAB amino acid AbC transporter HBA75_RS30270 ENOG4105E5Q amino acid AbC transporter HBA75_RS30295 ENOG4105D2S major facilitator superfamily HBA75_RS30300 ENOG410756H nucleotidyltransferase HBA75_RS30320 ENOG4105BZU Histidine kinase HBA75_RS30335 ENOG4106UIA HBA75_RS30340 ENOG4106UIA HBA75_RS30360 ENOG4108V5C ABC transporter HBA75_RS30365 ENOG4105DQ5 transport system permease protein HBA75_RS30370 ENOG4105EHG Permease protein HBA75_RS30390 ENOG4105D3R alkyl hydroperoxide reductase HBA75_RS30410 ENOG4105DFD Na H antiporter HBA75_RS30420 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_RS30435 ENOG4108W15 Protein of unknown function (DUF1456) HBA75_RS30445 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_RS30455 ENOG41085W3 Transposase HBA75_RS30615 ENOG4108JUB Transcriptional regulator HBA75_RS30625 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HBA75_RS30630 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HBA75_RS30665 ENOG4105UPD Calcium Proton HBA75_RS30670 ENOG410606W general stress protein HBA75_RS30680 ENOG4105DQ6 Transposase HBA75_RS30700 ENOG4107ZTW SNARE associated Golgi HBA75_RS30710 ENOG4105C3F Signal peptidase i HBA75_RS30720 ENOG4108IPJ Membrane HBA75_RS30725 ENOG4105C59 p-type ATPase HBA75_RS30730 ENOG4107U9T Pfam:Ribonuclease_BN HBA75_RS30740 ENOG4105KJF protein tyrosine phosphatase HBA75_RS30755 ENOG4105DQ6 Transposase HBA75_RS30770 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HBA75_RS31010 ENOG4105DQ6 Transposase HBA75_RS31020 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)