locus-tag	class	description
MC28_RS00080	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MC28_RS00100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MC28_RS00105	COG1116	anion transmembrane transporter activity
MC28_RS00110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_RS00115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_RS00120	COG0352	thiamine-phosphate diphosphorylase activity
MC28_RS00125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_RS00130	COG2104	thiamine diphosphate biosynthetic process
MC28_RS00135	COG2022	thiamine diphosphate biosynthetic process
MC28_RS00140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_RS00145	COG0351	phosphomethylpyrimidine kinase
MC28_RS00175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
MC28_RS00180	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
MC28_RS00185	COG2205	protein histidine kinase activity
MC28_RS00190	COG2814	Major facilitator Superfamily
MC28_RS00195	COG1846	Transcriptional regulator
MC28_RS00215	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_RS00220	COG1129	ABC transporter
MC28_RS00225	COG1879	ABC-type sugar transport system periplasmic component
MC28_RS00230	COG2252	PERMEase
MC28_RS00235	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS00295	COG0778	Nitroreductase
MC28_RS00300	COG2719	SpoVR family
MC28_RS00325	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC28_RS00330	COG1937	Protein conserved in bacteria
MC28_RS00335	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_RS00335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS00340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS00340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS00345	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_RS00350	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_RS00350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS00355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS00360	COG2210	Belongs to the sulfur carrier protein TusA family
MC28_RS00365	COG0730	response to heat
MC28_RS00375	COG1316	TRANSCRIPTIONal
MC28_RS00380	COG0604	alcohol dehydrogenase
MC28_RS00385	COG1283	sodium-dependent phosphate transmembrane transporter activity
MC28_RS00395	COG2814	Major facilitator Superfamily
MC28_RS00405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_RS00405	COG3711	transcriptional antiterminator
MC28_RS00410	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_RS00415	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_RS00435	COG3584	3D domain protein
MC28_RS00435	COG1388	LysM domain
MC28_RS00440	COG0577	efflux transmembrane transporter activity
MC28_RS00445	COG1136	(ABC) transporter
MC28_RS00470	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS00475	COG3546	catalase activity
MC28_RS00510	COG0586	Pfam SNARE associated Golgi protein
MC28_RS00545	COG0531	amino acid
MC28_RS00550	COG0475	glutathione-regulated potassium exporter activity
MC28_RS00560	COG1737	Transcriptional regulator
MC28_RS00570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS00570	COG1263	PTS System
MC28_RS00580	COG2259	Doxx family
MC28_RS00600	COG1522	sequence-specific DNA binding
MC28_RS00630	COG2076	Multidrug Resistance protein
MC28_RS00635	COG1309	transcriptional regulator
MC28_RS00640	COG2814	Major facilitator Superfamily
MC28_RS00645	COG1733	regulation of RNA biosynthetic process
MC28_RS00655	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_RS00665	COG4533	DNA binding
MC28_RS00670	COG2211	Major facilitator Superfamily
MC28_RS00680	COG0693	protein deglycase activity
MC28_RS00690	COG0531	amino acid
MC28_RS00695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MC28_RS00700	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS00705	COG1132	(ABC) transporter
MC28_RS00710	COG1132	(ABC) transporter
MC28_RS00715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_RS00720	COG0765	amino acid transport
MC28_RS00725	COG1126	abc transporter atp-binding protein
MC28_RS00745	COG0189	ligase activity
MC28_RS00765	COG0028	Belongs to the TPP enzyme family
MC28_RS00770	COG3527	Alpha-acetolactate decarboxylase
MC28_RS00780	COG0561	phosphatase activity
MC28_RS00795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC28_RS00810	COG0659	secondary active sulfate transmembrane transporter activity
MC28_RS00820	COG1024	Enoyl-CoA hydratase
MC28_RS00840	COG1363	Peptidase, m42
MC28_RS00870	COG0579	oxidoreductase
MC28_RS00890	COG0601	transmembrane transport
MC28_RS00895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_RS00900	COG0444	Belongs to the ABC transporter superfamily
MC28_RS00905	COG4608	Belongs to the ABC transporter superfamily
MC28_RS00910	COG5444	nuclease activity
MC28_RS00950	COG0477	Major facilitator Superfamily
MC28_RS00955	COG3290	protein histidine kinase activity
MC28_RS00960	COG4565	transcriptional regulatory protein
MC28_RS00965	COG3181	Tripartite tricarboxylate transporter family receptor
MC28_RS00970	COG0494	nUDIX hydrolase
MC28_RS00995	COG0305	Participates in initiation and elongation during chromosome replication
MC28_RS01025	COG0477	Major facilitator Superfamily
MC28_RS01070	COG3711	transcriptional antiterminator
MC28_RS01075	COG2190	(PTS) system
MC28_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS01075	COG1263	PTS System
MC28_RS01080	COG2723	6-phospho-beta-galactosidase activity
MC28_RS01090	COG1183	phosphatidylcholine synthase activity
MC28_RS01115	COG2814	Major facilitator Superfamily
MC28_RS01120	COG0640	Transcriptional regulator
MC28_RS01140	COG2376	Dihydroxyacetone kinase
MC28_RS01160	COG1959	2 iron, 2 sulfur cluster binding
MC28_RS01175	COG0745	RESPONSE REGULATOR receiver
MC28_RS01180	COG3850	Histidine kinase
MC28_RS01180	COG5002	protein histidine kinase activity
MC28_RS01215	COG3237	CsbD-like
MC28_RS01240	COG1191	sigma factor activity
MC28_RS01250	COG2208	phosphoserine phosphatase activity
MC28_RS01255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC28_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_RS01260	COG0784	Response regulator, receiver
MC28_RS01260	COG2205	protein histidine kinase activity
MC28_RS01260	COG2198	Histidine kinase
MC28_RS01315	COG0420	3'-5' exonuclease activity
MC28_RS01320	COG4717	serine-type aminopeptidase activity
MC28_RS01335	COG0714	Associated with various cellular activities
MC28_RS01340	COG0346	lactoylglutathione lyase activity
MC28_RS01345	COG0346	lactoylglutathione lyase activity
MC28_RS01350	COG0457	Tetratricopeptide repeat
MC28_RS01360	COG2267	carboxylic ester hydrolase activity
MC28_RS01370	COG3620	sequence-specific DNA binding
MC28_RS01375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MC28_RS01380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MC28_RS01390	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MC28_RS01405	COG0772	Belongs to the SEDS family
MC28_RS01415	COG3973	AAA domain
MC28_RS01425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC28_RS01450	COG0537	adenosine 5'-monophosphoramidase activity
MC28_RS01455	COG1131	(ABC) transporter
MC28_RS01460	COG4473	ABC transporter
MC28_RS01475	COG1309	transcriptional regulator
MC28_RS01485	COG3402	PFAM membrane-flanked domain
MC28_RS01490	COG3428	Bacterial PH domain
MC28_RS01540	COG3402	PFAM membrane-flanked domain
MC28_RS01545	COG3428	Bacterial PH domain
MC28_RS01550	COG2329	Antibiotic biosynthesis monooxygenase
MC28_RS01555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_RS01570	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MC28_RS01605	COG1309	transcriptional regulator
MC28_RS01610	COG1511	domain protein
MC28_RS01635	COG1609	Transcriptional regulator
MC28_RS01645	COG1234	tRNA 3'-trailer cleavage
MC28_RS01650	COG0095	Lipoate-protein ligase
MC28_RS01660	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS01680	COG1408	metallophosphoesterase
MC28_RS01690	COG1078	dGTPase activity
MC28_RS01700	COG1595	DNA-templated transcription, initiation
MC28_RS01705	COG3708	Transcriptional regulator
MC28_RS01705	COG2207	Transcriptional regulator
MC28_RS01715	COG2205	protein histidine kinase activity
MC28_RS01720	COG0745	RESPONSE REGULATOR receiver
MC28_RS01740	COG0501	Belongs to the peptidase M48B family
MC28_RS01745	COG0840	transmembrane signaling receptor activity
MC28_RS01750	COG0697	spore germination
MC28_RS01755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MC28_RS01760	COG2224	Isocitrate lyase
MC28_RS01790	COG4903	ComK protein
MC28_RS01795	COG0398	Pfam SNARE associated Golgi protein
MC28_RS01815	COG0202	RNA polymerase activity
MC28_RS01855	COG0179	Fumarylacetoacetate (FAA) hydrolase
MC28_RS01880	COG0367	asparagine synthase
MC28_RS01890	COG0753	catalase activity
MC28_RS01895	COG0004	ammonium transporteR
MC28_RS01915	COG2996	Protein conserved in bacteria
MC28_RS01940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS01955	COG0561	phosphatase activity
MC28_RS01975	COG2267	carboxylic ester hydrolase activity
MC28_RS01990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_RS01995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC28_RS02000	COG5504	Zn-dependent protease
MC28_RS02015	COG0180	Tryptophanyl-tRNA synthetase
MC28_RS02025	COG4166	transmembrane transport
MC28_RS02030	COG0601	transmembrane transport
MC28_RS02035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_RS02040	COG0444	Belongs to the ABC transporter superfamily
MC28_RS02045	COG4608	Belongs to the ABC transporter superfamily
MC28_RS02060	COG0534	Mate efflux family protein
MC28_RS02065	COG4166	transmembrane transport
MC28_RS02080	COG0861	Integral membrane protein TerC family
MC28_RS02090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_RS02100	COG1164	Oligoendopeptidase f
MC28_RS02110	COG2346	COG2346, Truncated hemoglobins
MC28_RS02115	COG4116	CYTH
MC28_RS02125	COG2357	RelA SpoT domain protein
MC28_RS02135	COG0564	pseudouridine synthase activity
MC28_RS02150	COG0772	Belongs to the SEDS family
MC28_RS02155	COG1216	Glycosyl transferase, family 2
MC28_RS02175	COG0457	Tetratricopeptide repeat
MC28_RS02175	COG0463	Glycosyl transferase, family 2
MC28_RS02195	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MC28_RS02210	COG1091	dTDP-4-dehydrorhamnose reductase activity
MC28_RS02255	COG2153	protein acetylation
MC28_RS02265	COG2382	esterase
MC28_RS02280	COG5492	domain, Protein
MC28_RS02285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_RS02295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC28_RS02295	COG0512	Glutamine amidotransferase of anthranilate synthase
MC28_RS02300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC28_RS02315	COG0133	tryptophan synthase activity
MC28_RS02330	COG1620	l-lactate permease
MC28_RS02335	COG5634	Uncharacterized conserved protein (DUF2278)
MC28_RS02400	COG2226	methyltransferase
MC28_RS02420	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_RS02430	COG1476	TRANSCRIPTIONal
MC28_RS02465	COG4152	abc transporter atp-binding protein
MC28_RS02470	COG1668	transmembrane transport
MC28_RS02510	COG0582	viral genome integration into host DNA
MC28_RS02540	COG1686	Belongs to the peptidase S11 family
MC28_RS02545	COG0681	Belongs to the peptidase S26 family
MC28_RS02585	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS02595	COG1176	ABC-type spermidine putrescine transport system, permease component I
MC28_RS02600	COG1177	transmembrane transport
MC28_RS02605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MC28_RS02615	COG2409	Drug exporters of the RND superfamily
MC28_RS02625	COG0564	pseudouridine synthase activity
MC28_RS02635	COG2340	Cysteine-rich secretory protein family
MC28_RS02640	COG0247	lactate metabolic process
MC28_RS02645	COG0277	FAD linked oxidase domain protein
MC28_RS02650	COG3835	regulator
MC28_RS02660	COG0745	RESPONSE REGULATOR receiver
MC28_RS02665	COG5002	protein histidine kinase activity
MC28_RS02670	COG2186	Transcriptional regulator
MC28_RS02690	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MC28_RS02700	COG2116	formate transmembrane transporter activity
MC28_RS02705	COG0861	Integral membrane protein TerC family
MC28_RS02710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_RS02720	COG2030	dehydratase
MC28_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS02745	COG3243	poly(R)-hydroxyalkanoic acid synthase
MC28_RS02755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_RS02770	COG1840	ABC-type Fe3 transport system, periplasmic component
MC28_RS02775	COG3842	ATPase activity
MC28_RS02800	COG1349	DNA-binding transcription factor activity
MC28_RS02815	COG0235	Class ii aldolase
MC28_RS02825	COG2861	carbohydrate metabolic process
MC28_RS02835	COG3852	Histidine kinase
MC28_RS02840	COG1846	Transcriptional regulator
MC28_RS02850	COG2318	DinB family
MC28_RS02860	COG5002	protein histidine kinase activity
MC28_RS02870	COG0720	synthase
MC28_RS02885	COG4873	Protein conserved in bacteria
MC28_RS02900	COG0456	acetyltransferase
MC28_RS02915	COG1780	Probably involved in ribonucleotide reductase function
MC28_RS02920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC28_RS02925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC28_RS02930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC28_RS02935	COG0531	amino acid
MC28_RS02940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC28_RS02955	COG2204	response regulator
MC28_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS02970	COG1725	Transcriptional regulator
MC28_RS02975	COG1131	(ABC) transporter
MC28_RS02985	COG1131	(ABC) transporter
MC28_RS02990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MC28_RS03005	COG1522	sequence-specific DNA binding
MC28_RS03015	COG1335	isochorismatase
MC28_RS03025	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_RS03030	COG2070	2-Nitropropane dioxygenase
MC28_RS03035	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MC28_RS03045	COG1696	Membrane protein involved in D-alanine export
MC28_RS03070	COG0716	FMN binding
MC28_RS03105	COG0534	Mate efflux family protein
MC28_RS03130	COG1846	Transcriptional regulator
MC28_RS03140	COG1301	dicarboxylic acid transport
MC28_RS03145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_RS03150	COG4709	membrane
MC28_RS03155	COG3874	Sporulation protein YtfJ
MC28_RS03175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_RS03180	COG0028	Belongs to the TPP enzyme family
MC28_RS03185	COG0440	acetolactate synthase activity
MC28_RS03205	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MC28_RS03235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MC28_RS03245	COG0107	imidazoleglycerol-phosphate synthase activity
MC28_RS03255	COG0140	phosphoribosyl-ATP diphosphatase activity
MC28_RS03260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC28_RS03270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_RS03275	COG1183	phosphatidylcholine synthase activity
MC28_RS03280	COG1368	sulfuric ester hydrolase activity
MC28_RS03290	COG0019	diaminopimelate decarboxylase activity
MC28_RS03310	COG0529	Catalyzes the synthesis of activated sulfate
MC28_RS03315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_RS03335	COG1648	precorrin-2 dehydrogenase activity
MC28_RS03340	COG0733	neurotransmitter:sodium symporter activity
MC28_RS03360	COG1757	Na H antiporter
MC28_RS03375	COG4758	membrane
MC28_RS03380	COG4585	Histidine kinase
MC28_RS03385	COG2197	response regulator
MC28_RS03395	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS03405	COG2226	methyltransferase
MC28_RS03445	COG0730	response to heat
MC28_RS03450	COG0306	phosphate transporter
MC28_RS03455	COG1392	Phosphate transport regulator
MC28_RS03460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_RS03475	COG3852	Histidine kinase
MC28_RS03480	COG1801	Protein of unknown function DUF72
MC28_RS03490	COG0582	viral genome integration into host DNA
MC28_RS03495	COG5002	protein histidine kinase activity
MC28_RS03510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MC28_RS03510	COG0392	lysyltransferase activity
MC28_RS03525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_RS03530	COG1686	Belongs to the peptidase S11 family
MC28_RS03535	COG2715	membrane protein required for spore maturation
MC28_RS03540	COG0700	Nucleoside recognition
MC28_RS03545	COG1187	pseudouridine synthase activity
MC28_RS03555	COG1333	cytochrome c biogenesis protein
MC28_RS03560	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC28_RS03565	COG0745	RESPONSE REGULATOR receiver
MC28_RS03570	COG5002	protein histidine kinase activity
MC28_RS03575	COG2096	Adenosyltransferase
MC28_RS03580	COG4942	peptidase
MC28_RS03590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MC28_RS03595	COG1141	Ferredoxin
MC28_RS03600	COG4955	Helix-turn-helix domain
MC28_RS03605	COG0514	ATP-dependent DNA helicase (RecQ)
MC28_RS03610	COG1266	CAAX protease self-immunity
MC28_RS03620	COG1408	metallophosphoesterase
MC28_RS03625	COG0789	Transcriptional regulator
MC28_RS03630	COG4862	establishment of competence for transformation
MC28_RS03635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC28_RS03655	COG0492	ferredoxin-NADP+ reductase activity
MC28_RS03660	COG0252	asparaginase activity
MC28_RS03725	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MC28_RS03740	COG0142	geranyltranstransferase activity
MC28_RS03750	COG0142	geranyltranstransferase activity
MC28_RS03775	COG0457	Tetratricopeptide repeat
MC28_RS03795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MC28_RS03800	COG2010	Cytochrome c
MC28_RS03800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MC28_RS03805	COG4347	Protein of unknown function (DUF1405)
MC28_RS03820	COG2738	Putative neutral zinc metallopeptidase
MC28_RS03830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS03835	COG1694	Mazg nucleotide pyrophosphohydrolase
MC28_RS03850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_RS03855	COG0438	transferase activity, transferring glycosyl groups
MC28_RS03890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC28_RS03890	COG1199	ATP-dependent helicase activity
MC28_RS03910	COG3935	DnaD domain protein
MC28_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MC28_RS03925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_RS03925	COG4499	WXG100 protein secretion system (Wss), protein YukC
MC28_RS03970	COG3599	regulation of cell shape
MC28_RS03975	COG0116	Belongs to the methyltransferase superfamily
MC28_RS03980	COG4974	Belongs to the 'phage' integrase family
MC28_RS04070	COG1199	ATP-dependent helicase activity
MC28_RS04075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MC28_RS04085	COG3173	Aminoglycoside phosphotransferase
MC28_RS04090	COG0024	Methionine aminopeptidase
MC28_RS04100	COG2233	PERMEase
MC28_RS04105	COG2311	Membrane
MC28_RS04110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MC28_RS04120	COG0456	acetyltransferase
MC28_RS04155	COG0754	glutathionylspermidine amidase activity
MC28_RS04170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_RS04185	COG0454	-acetyltransferase
MC28_RS04205	COG0328	RNA-DNA hybrid ribonuclease activity
MC28_RS04240	COG3403	YqcI/YcgG family
MC28_RS04245	COG1280	lysine exporter protein (LysE YggA)
MC28_RS04260	COG3162	membrane
MC28_RS04265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_RS04270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_RS04280	COG0475	glutathione-regulated potassium exporter activity
MC28_RS04285	COG0789	Transcriptional regulator
MC28_RS04285	COG4978	Transcriptional regulator
MC28_RS04295	COG2323	membrane
MC28_RS04300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MC28_RS04330	COG2814	Major facilitator Superfamily
MC28_RS04350	COG1923	regulation of RNA biosynthetic process
MC28_RS04360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC28_RS04365	COG1360	Flagellar Motor Protein
MC28_RS04370	COG2201	protein-glutamate methylesterase activity
MC28_RS04375	COG2198	Histidine kinase
MC28_RS04375	COG0643	Histidine kinase
MC28_RS04380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_RS04380	COG1776	CheC inhibitor of MCP methylation
MC28_RS04395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC28_RS04415	COG1256	bacterial-type flagellum assembly
MC28_RS04420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_RS04440	COG1815	bacterial-type flagellum-dependent cell motility
MC28_RS04445	COG1558	bacterial-type flagellum-dependent cell motility
MC28_RS04455	COG1766	The M ring may be actively involved in energy transduction
MC28_RS04460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_RS04470	COG1157	protein secretion by the type III secretion system
MC28_RS04490	COG1749	Flagellar hook protein flgE
MC28_RS04505	COG0835	chemotaxis
MC28_RS04505	COG0784	Response regulator, receiver
MC28_RS04515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_RS04520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_RS04525	COG0741	lytic transglycosylase activity
MC28_RS04535	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_RS04540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_RS04540	COG1776	CheC inhibitor of MCP methylation
MC28_RS04550	COG1338	Plays a role in the flagellum-specific transport system
MC28_RS04555	COG1987	bacterial-type flagellum assembly
MC28_RS04565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC28_RS04570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC28_RS04575	COG1419	protein localization to endoplasmic reticulum
MC28_RS04580	COG4786	Flagellar basal body rod
MC28_RS04620	COG2329	Antibiotic biosynthesis monooxygenase
MC28_RS04635	COG2814	Major facilitator Superfamily
MC28_RS04645	COG0583	DNA-binding transcription factor activity
MC28_RS04650	COG3842	ATPase activity
MC28_RS04655	COG1840	ABC-type Fe3 transport system, periplasmic component
MC28_RS04665	COG1234	tRNA 3'-trailer cleavage
MC28_RS04695	COG0406	alpha-ribazole phosphatase activity
MC28_RS04715	COG1846	Transcriptional regulator
MC28_RS04725	COG0367	asparagine synthase
MC28_RS04755	COG1802	Transcriptional regulator
MC28_RS04760	COG0697	spore germination
MC28_RS04770	COG0523	cobalamin synthesis protein
MC28_RS04775	COG0701	Predicted permease
MC28_RS04785	COG0438	transferase activity, transferring glycosyl groups
MC28_RS04785	COG1216	Glycosyl transferase, family 2
MC28_RS04790	COG1757	Na H antiporter
MC28_RS04795	COG0789	Transcriptional regulator
MC28_RS04800	COG4221	oxidoreductase activity
MC28_RS04820	COG0534	Mate efflux family protein
MC28_RS04825	COG3340	Belongs to the peptidase S51 family
MC28_RS04845	COG0785	Cytochrome C biogenesis protein
MC28_RS04850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_RS04870	COG2733	membrane
MC28_RS04905	COG1131	(ABC) transporter
MC28_RS04920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_RS04925	COG0528	UMP kinase activity
MC28_RS04935	COG1027	Aspartate ammonia-lyase
MC28_RS04940	COG0281	malic enzyme
MC28_RS04945	COG4191	Histidine kinase
MC28_RS04950	COG0784	Response regulator, receiver
MC28_RS04955	COG1846	Transcriptional regulator
MC28_RS04965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_RS04980	COG3620	sequence-specific DNA binding
MC28_RS05035	COG0477	Major facilitator Superfamily
MC28_RS05040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_RS05050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC28_RS05055	COG2223	nitrite transmembrane transporter activity
MC28_RS05060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_RS05075	COG2244	polysaccharide biosynthetic process
MC28_RS05080	COG0733	neurotransmitter:sodium symporter activity
MC28_RS05090	COG5566	PFAM Mor transcription activator
MC28_RS05095	COG2323	membrane
MC28_RS05110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_RS05120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_RS05125	COG0028	Belongs to the TPP enzyme family
MC28_RS05145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC28_RS05165	COG2814	Major facilitator Superfamily
MC28_RS05170	COG3384	dioxygenase
MC28_RS05180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_RS05200	COG4166	transmembrane transport
MC28_RS05210	COG0535	radical SAM domain protein
MC28_RS05215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS05235	COG1914	H( )-stimulated, divalent metal cation uptake system
MC28_RS05250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MC28_RS05260	COG0531	amino acid
MC28_RS05280	COG1280	lysine exporter protein (LysE YggA)
MC28_RS05285	COG2390	Transcriptional regulator
MC28_RS05295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS05300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MC28_RS05305	COG0295	cytidine deaminase activity
MC28_RS05335	COG0583	DNA-binding transcription factor activity
MC28_RS05350	COG0006	proline dipeptidase activity
MC28_RS05355	COG2132	Multicopper oxidase
MC28_RS05360	COG4193	domain, Protein
MC28_RS05365	COG1073	alpha beta
MC28_RS05400	COG1760	l-serine dehydratase
MC28_RS05405	COG1760	l-serine dehydratase
MC28_RS05410	COG0814	amino acid
MC28_RS05420	COG1136	(ABC) transporter
MC28_RS05425	COG0577	efflux transmembrane transporter activity
MC28_RS05430	COG0745	RESPONSE REGULATOR receiver
MC28_RS05435	COG2205	protein histidine kinase activity
MC28_RS05460	COG0772	Belongs to the SEDS family
MC28_RS05465	COG2239	Acts as a magnesium transporter
MC28_RS05475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC28_RS05495	COG1073	alpha beta
MC28_RS05520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC28_RS05530	COG0583	DNA-binding transcription factor activity
MC28_RS05550	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS05560	COG2372	response to copper ion
MC28_RS05560	COG1276	copper resistance
MC28_RS05565	COG4549	nuclear export factor GLE1
MC28_RS05570	COG0697	spore germination
MC28_RS05575	COG0583	DNA-binding transcription factor activity
MC28_RS05580	COG1959	2 iron, 2 sulfur cluster binding
MC28_RS05585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MC28_RS05590	COG0778	Nitroreductase
MC28_RS05605	COG0628	permease
MC28_RS05620	COG1231	oxidoreductase activity
MC28_RS05625	COG0523	cobalamin synthesis protein
MC28_RS05635	COG0411	ABC transporter
MC28_RS05645	COG0559	Belongs to the binding-protein-dependent transport system permease family
MC28_RS05655	COG0583	DNA-binding transcription factor activity
MC28_RS05685	COG1271	oxidase subunit
MC28_RS05690	COG1294	oxidase, subunit
MC28_RS05695	COG4988	ABC transporter
MC28_RS05700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MC28_RS05705	COG0463	Glycosyl transferase, family 2
MC28_RS05725	COG1686	Belongs to the peptidase S11 family
MC28_RS05740	COG0791	NLP P60 protein
MC28_RS05740	COG1388	LysM domain
MC28_RS05750	COG1132	(ABC) transporter
MC28_RS05755	COG0745	RESPONSE REGULATOR receiver
MC28_RS05760	COG5002	protein histidine kinase activity
MC28_RS05770	COG0300	oxidoreductase activity
MC28_RS05790	COG5658	integral membrane protein
MC28_RS05805	COG0460	homoserine dehydrogenase
MC28_RS05815	COG0083	homoserine kinase activity
MC28_RS05830	COG1316	TRANSCRIPTIONal
MC28_RS05840	COG0745	RESPONSE REGULATOR receiver
MC28_RS05845	COG5002	protein histidine kinase activity
MC28_RS05860	COG1285	pathogenesis
MC28_RS05865	COG1247	-acetyltransferase
MC28_RS05885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC28_RS05895	COG1082	Xylose isomerase domain protein TIM barrel
MC28_RS05905	COG2814	Major facilitator Superfamily
MC28_RS05910	COG1279	arginine transmembrane transporter activity
MC28_RS05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS05925	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC28_RS06015	COG4695	Portal protein
MC28_RS06050	COG0577	efflux transmembrane transporter activity
MC28_RS06055	COG2002	toxin-antitoxin pair type II binding
MC28_RS06060	COG1404	Belongs to the peptidase S8 family
MC28_RS06065	COG0640	Transcriptional regulator
MC28_RS06070	COG0667	Aldo Keto reductase
MC28_RS06110	COG3949	Membrane
MC28_RS06115	COG0783	Belongs to the Dps family
MC28_RS06130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_RS06140	COG1231	oxidoreductase activity
MC28_RS06145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS06150	COG4989	oxidoreductase activity
MC28_RS06155	COG0523	cobalamin synthesis protein
MC28_RS06165	COG0803	Belongs to the bacterial solute-binding protein 9 family
MC28_RS06170	COG0702	epimerase
MC28_RS06180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC28_RS06190	COG4166	transmembrane transport
MC28_RS06195	COG0346	lactoylglutathione lyase activity
MC28_RS06215	COG5337	Spore coat protein CotH
MC28_RS06220	COG1051	belongs to the nudix hydrolase family
MC28_RS06225	COG0586	Pfam SNARE associated Golgi protein
MC28_RS06230	COG2244	polysaccharide biosynthetic process
MC28_RS06240	COG0701	Predicted permease
MC28_RS06245	COG3689	TIGRFAM TIGR03943 family protein
MC28_RS06250	COG1607	acyl-coa hydrolase
MC28_RS06255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_RS06270	COG0702	epimerase
MC28_RS06275	COG2839	Protein conserved in bacteria
MC28_RS06280	COG1253	flavin adenine dinucleotide binding
MC28_RS06305	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC28_RS06325	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_RS06335	COG1876	peptidase activity
MC28_RS06345	COG0154	amidase activity
MC28_RS06350	COG2211	Major facilitator Superfamily
MC28_RS06365	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_RS06375	COG0561	phosphatase activity
MC28_RS06380	COG1846	Transcriptional regulator
MC28_RS06385	COG2814	Major facilitator Superfamily
MC28_RS06395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC28_RS06410	COG1819	glycosyl
MC28_RS06415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS06420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS06450	COG0456	acetyltransferase
MC28_RS06530	COG3874	Sporulation protein YtfJ
MC28_RS06555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC28_RS06575	COG0346	lactoylglutathione lyase activity
MC28_RS06610	COG0426	domain, Protein
MC28_RS06610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MC28_RS06620	COG0386	Belongs to the glutathione peroxidase family
MC28_RS06625	COG1305	Transglutaminase-like
MC28_RS06630	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MC28_RS06635	COG0714	Associated with various cellular activities
MC28_RS06640	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MC28_RS06645	COG1140	nitrate reductase beta subunit
MC28_RS06650	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MC28_RS06655	COG2181	nitrate reductase activity
MC28_RS06660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_RS06665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC28_RS06670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_RS06675	COG0303	'Molybdopterin
MC28_RS06680	COG0314	molybdopterin synthase activity
MC28_RS06690	COG2223	nitrite transmembrane transporter activity
MC28_RS06700	COG1648	precorrin-2 dehydrogenase activity
MC28_RS06710	COG1587	Uroporphyrinogen-III synthase
MC28_RS06710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC28_RS06715	COG2146	nitrite reductase [NAD(P)H] activity
MC28_RS06720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_RS06725	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MC28_RS06755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS06800	COG2359	stage V sporulation protein S
MC28_RS06815	COG1418	mRNA catabolic process
MC28_RS06820	COG0488	(ABC) transporter
MC28_RS06835	COG0629	single-stranded DNA binding
MC28_RS06850	COG1413	lyase activity
MC28_RS06865	COG2521	methyltransferase
MC28_RS06865	COG2136	Putative SAM-dependent methyltransferase
MC28_RS06870	COG0018	arginyl-trna synthetase
MC28_RS06905	COG1309	transcriptional regulator
MC28_RS06920	COG0017	Asparaginyl-tRNA synthetase
MC28_RS06925	COG0733	neurotransmitter:sodium symporter activity
MC28_RS06930	COG2267	carboxylic ester hydrolase activity
MC28_RS06950	COG2610	gluconate transmembrane transporter activity
MC28_RS06960	COG1794	racemase activity, acting on amino acids and derivatives
MC28_RS06970	COG0456	acetyltransferase
MC28_RS06975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC28_RS06990	COG0546	phosphoglycolate phosphatase activity
MC28_RS07005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_RS07020	COG0768	penicillin binding
MC28_RS07030	COG0204	Acyl-transferase
MC28_RS07035	COG1272	protein, Hemolysin III
MC28_RS07045	COG0805	protein transport
MC28_RS07055	COG1307	EDD domain protein, DegV family
MC28_RS07060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MC28_RS07065	COG1999	signal sequence binding
MC28_RS07070	COG0071	Belongs to the small heat shock protein (HSP20) family
MC28_RS07075	COG0367	asparagine synthase
MC28_RS07090	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_RS07095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS07100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_RS07115	COG1335	isochorismatase
MC28_RS07120	COG1051	belongs to the nudix hydrolase family
MC28_RS07125	COG0668	transmembrane transport
MC28_RS07130	COG2203	Gaf domain
MC28_RS07130	COG4585	Histidine kinase
MC28_RS07135	COG2197	response regulator
MC28_RS07140	COG1737	Transcriptional regulator
MC28_RS07145	COG1064	alcohol dehydrogenase
MC28_RS07170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MC28_RS07200	COG0517	IMP dehydrogenase activity
MC28_RS07200	COG1125	glycine betaine transport
MC28_RS07205	COG1174	glycine betaine transport
MC28_RS07240	COG1253	flavin adenine dinucleotide binding
MC28_RS07245	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS07250	COG5506	Protein of unknown function (DUF1694)
MC28_RS07265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_RS07270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MC28_RS07275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MC28_RS07280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_RS07285	COG0456	acetyltransferase
MC28_RS07290	COG3829	transcription factor binding
MC28_RS07295	COG1509	lysine 2,3-aminomutase activity
MC28_RS07325	COG4991	sh3 domain protein
MC28_RS07325	COG3064	Membrane
MC28_RS07325	COG0515	serine threonine protein kinase
MC28_RS07335	COG0671	phosphoesterase, PA-phosphatase related
MC28_RS07340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC28_RS07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_RS07350	COG0582	viral genome integration into host DNA
MC28_RS07385	COG1396	sequence-specific DNA binding
MC28_RS07410	COG5377	YqaJ viral recombinase family
MC28_RS07415	COG3723	Recombinational DNA repair protein, rece pathway
MC28_RS07655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC28_RS07685	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS07705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_RS07705	COG4499	WXG100 protein secretion system (Wss), protein YukC
MC28_RS07715	COG2814	Major facilitator Superfamily
MC28_RS07725	COG0372	Belongs to the citrate synthase family
MC28_RS07730	COG2079	MmgE PrpD family protein
MC28_RS07735	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MC28_RS07740	COG1960	acyl-CoA dehydrogenase activity
MC28_RS07745	COG2084	Dehydrogenase
MC28_RS07755	COG1280	lysine exporter protein (LysE YggA)
MC28_RS07760	COG1024	Enoyl-CoA hydratase
MC28_RS07775	COG0420	3'-5' exonuclease activity
MC28_RS07805	COG2223	nitrite transmembrane transporter activity
MC28_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS07815	COG1169	isochorismate synthase
MC28_RS07820	COG1021	2,3-dihydroxybenzoate-AMP ligase
MC28_RS07825	COG3433	isochorismatase activity
MC28_RS07825	COG1535	isochorismatase
MC28_RS07830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MC28_RS07835	COG3251	PFAM MbtH domain protein
MC28_RS07840	COG2814	Major facilitator Superfamily
MC28_RS07855	COG0776	regulation of translation
MC28_RS07865	COG2318	DinB family
MC28_RS07875	COG1115	amino acid carrier protein
MC28_RS07885	COG2329	Antibiotic biosynthesis monooxygenase
MC28_RS07890	COG1187	pseudouridine synthase activity
MC28_RS07895	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC28_RS07900	COG1136	(ABC) transporter
MC28_RS07910	COG0596	Alpha beta hydrolase
MC28_RS07925	COG0028	Belongs to the TPP enzyme family
MC28_RS07960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_RS07970	COG2207	Transcriptional regulator
MC28_RS08005	COG5002	protein histidine kinase activity
MC28_RS08015	COG0745	RESPONSE REGULATOR receiver
MC28_RS08035	COG1846	Transcriptional regulator
MC28_RS08050	COG1309	transcriptional regulator
MC28_RS08070	COG1247	-acetyltransferase
MC28_RS08095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MC28_RS08105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS08135	COG0583	DNA-binding transcription factor activity
MC28_RS08140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC28_RS08145	COG0583	DNA-binding transcription factor activity
MC28_RS08150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MC28_RS08155	COG2258	MOSC domain
MC28_RS08170	COG1132	(ABC) transporter
MC28_RS08175	COG1132	(ABC) transporter
MC28_RS08190	COG1396	sequence-specific DNA binding
MC28_RS08225	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
MC28_RS08230	COG1595	DNA-templated transcription, initiation
MC28_RS08255	COG1649	PFAM Uncharacterised BCR, COG1649
MC28_RS08275	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MC28_RS08280	COG2971	BadF BadG BcrA BcrD
MC28_RS08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS08335	COG2226	methyltransferase
MC28_RS08340	COG3961	Belongs to the TPP enzyme family
MC28_RS08405	COG2002	toxin-antitoxin pair type II binding
MC28_RS08415	COG0730	response to heat
MC28_RS08420	COG0110	maltose O-acetyltransferase activity
MC28_RS08425	COG1686	Belongs to the peptidase S11 family
MC28_RS08440	COG0768	penicillin binding
MC28_RS08445	COG1595	DNA-templated transcription, initiation
MC28_RS08455	COG0768	penicillin binding
MC28_RS08460	COG0768	penicillin binding
MC28_RS08500	COG0697	spore germination
MC28_RS08510	COG3397	chitin binding
MC28_RS08515	COG0823	Involved in the tonB-independent uptake of proteins
MC28_RS08525	COG1408	metallophosphoesterase
MC28_RS08535	COG1131	(ABC) transporter
MC28_RS08545	COG1309	transcriptional regulator
MC28_RS08555	COG1960	acyl-CoA dehydrogenase activity
MC28_RS08560	COG0439	Biotin carboxylase
MC28_RS08565	COG0511	ligase activity, forming carbon-carbon bonds
MC28_RS08570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MC28_RS08575	COG1024	Enoyl-CoA hydratase
MC28_RS08580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MC28_RS08585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_RS08640	COG2318	DinB family
MC28_RS08645	COG1686	Belongs to the peptidase S11 family
MC28_RS08670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_RS08690	COG3227	Zinc metalloprotease (Elastase)
MC28_RS08695	COG2207	Transcriptional regulator
MC28_RS08725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MC28_RS08755	COG1733	regulation of RNA biosynthetic process
MC28_RS08760	COG2226	methyltransferase
MC28_RS08790	COG0697	spore germination
MC28_RS08795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS08820	COG2323	membrane
MC28_RS08830	COG0693	protein deglycase activity
MC28_RS08840	COG3386	PFAM SMP-30 Gluconolaconase
MC28_RS08845	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MC28_RS08850	COG3773	Cell wall hydrolase
MC28_RS08860	COG0745	RESPONSE REGULATOR receiver
MC28_RS08865	COG2205	protein histidine kinase activity
MC28_RS08875	COG0583	DNA-binding transcription factor activity
MC28_RS08880	COG0667	Aldo Keto reductase
MC28_RS08885	COG0488	(ABC) transporter
MC28_RS08895	COG1136	(ABC) transporter
MC28_RS08900	COG0577	efflux transmembrane transporter activity
MC28_RS08920	COG0460	homoserine dehydrogenase
MC28_RS08925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS08935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MC28_RS09060	COG2124	cytochrome p450
MC28_RS09095	COG0561	phosphatase activity
MC28_RS09100	COG5002	protein histidine kinase activity
MC28_RS09105	COG0768	penicillin binding
MC28_RS09115	COG1819	glycosyl
MC28_RS09120	COG1794	racemase activity, acting on amino acids and derivatives
MC28_RS09140	COG2205	protein histidine kinase activity
MC28_RS09150	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MC28_RS09155	COG0604	alcohol dehydrogenase
MC28_RS09160	COG0671	phosphoesterase, PA-phosphatase related
MC28_RS09165	COG0768	penicillin binding
MC28_RS09220	COG0789	Transcriptional regulator
MC28_RS09225	COG2814	Major facilitator Superfamily
MC28_RS09240	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_RS09260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS09265	COG0697	spore germination
MC28_RS09295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_RS09305	COG2223	nitrite transmembrane transporter activity
MC28_RS09315	COG2816	NAD+ diphosphatase activity
MC28_RS09320	COG0592	DNA-directed DNA polymerase activity
MC28_RS09350	COG3878	Protein conserved in bacteria
MC28_RS09375	COG4667	esterase of the alpha-beta hydrolase superfamily
MC28_RS09415	COG0322	excinuclease ABC activity
MC28_RS09445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_RS09470	COG1011	Hydrolase
MC28_RS09475	COG0745	RESPONSE REGULATOR receiver
MC28_RS09480	COG5002	protein histidine kinase activity
MC28_RS09510	COG1136	(ABC) transporter
MC28_RS09515	COG0577	efflux transmembrane transporter activity
MC28_RS09525	COG1073	alpha beta
MC28_RS09530	COG0657	acetylesterase activity
MC28_RS09535	COG1523	belongs to the glycosyl hydrolase 13 family
MC28_RS09540	COG3227	Zinc metalloprotease (Elastase)
MC28_RS09545	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS09555	COG0201	protein transport
MC28_RS09560	COG0697	spore germination
MC28_RS09565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS09600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS09615	COG2959	enzyme of heme biosynthesis
MC28_RS09655	COG1309	transcriptional regulator
MC28_RS09665	COG3284	Transcriptional regulator
MC28_RS09685	COG1349	DNA-binding transcription factor activity
MC28_RS09705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC28_RS09710	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_RS09715	COG0022	dehydrogenase e1 component
MC28_RS09720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC28_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS09760	COG4176	ABC-type proline glycine betaine transport system permease component
MC28_RS09765	COG4175	Glycine betaine
MC28_RS09765	COG0517	IMP dehydrogenase activity
MC28_RS09795	COG2153	protein acetylation
MC28_RS09810	COG3397	chitin binding
MC28_RS09820	COG1819	glycosyl
MC28_RS09840	COG2205	protein histidine kinase activity
MC28_RS09845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC28_RS09850	COG2315	Protein conserved in bacteria
MC28_RS09900	COG3973	AAA domain
MC28_RS09910	COG0514	ATP-dependent DNA helicase (RecQ)
MC28_RS09935	COG4637	Psort location Cytoplasmic, score
MC28_RS09950	COG3397	chitin binding
MC28_RS09955	COG2318	DinB family
MC28_RS09970	COG1162	GTPase activity
MC28_RS09975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MC28_RS09980	COG1115	amino acid carrier protein
MC28_RS09985	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS09990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC28_RS09995	COG3938	Belongs to the proline racemase family
MC28_RS10000	COG3938	Belongs to the proline racemase family
MC28_RS10005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_RS10055	COG1078	dGTPase activity
MC28_RS10060	COG0586	Pfam SNARE associated Golgi protein
MC28_RS10070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MC28_RS10075	COG4166	transmembrane transport
MC28_RS10085	COG4948	Mandelate Racemase Muconate Lactonizing
MC28_RS10130	COG2936	dipeptidyl-peptidase activity
MC28_RS10135	COG3850	Histidine kinase
MC28_RS10135	COG5002	protein histidine kinase activity
MC28_RS10165	COG1164	Oligoendopeptidase f
MC28_RS10170	COG0456	acetyltransferase
MC28_RS10175	COG1307	EDD domain protein, DegV family
MC28_RS10215	COG2814	Major facilitator Superfamily
MC28_RS10225	COG1664	Polymer-forming cytoskeletal
MC28_RS10230	COG0789	Transcriptional regulator
MC28_RS10235	COG4533	DNA binding
MC28_RS10265	COG2261	transglycosylase associated protein
MC28_RS10280	COG2226	methyltransferase
MC28_RS10315	COG0436	Aminotransferase
MC28_RS10320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC28_RS10345	COG1131	(ABC) transporter
MC28_RS10390	COG0628	permease
MC28_RS10400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_RS10405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_RS10410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_RS10440	COG2746	aminoglycoside 3-N-acetyltransferase activity
MC28_RS10470	COG0697	spore germination
MC28_RS10505	COG0346	lactoylglutathione lyase activity
MC28_RS10510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS10535	COG2814	Major facilitator Superfamily
MC28_RS10540	COG0861	Integral membrane protein TerC family
MC28_RS10545	COG1368	sulfuric ester hydrolase activity
MC28_RS10550	COG0488	(ABC) transporter
MC28_RS10555	COG2409	Drug exporters of the RND superfamily
MC28_RS10555	COG1033	growth of symbiont in host cell
MC28_RS10560	COG1309	transcriptional regulator
MC28_RS10575	COG0287	Prephenate dehydrogenase
MC28_RS10590	COG1605	Chorismate mutase
MC28_RS10590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MC28_RS10630	COG1388	LysM domain
MC28_RS10630	COG3584	3D domain protein
MC28_RS10640	COG0346	lactoylglutathione lyase activity
MC28_RS10645	COG0519	Catalyzes the synthesis of GMP from XMP
MC28_RS10650	COG0431	NADPH-dependent FMN reductase
MC28_RS10675	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_RS10680	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_RS10690	COG2390	Transcriptional regulator
MC28_RS10695	COG1070	Carbohydrate kinase
MC28_RS10730	COG2329	Antibiotic biosynthesis monooxygenase
MC28_RS10750	COG1472	Belongs to the glycosyl hydrolase 3 family
MC28_RS10755	COG2207	Transcriptional regulator
MC28_RS10760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS10765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MC28_RS10770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MC28_RS10775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_RS10780	COG4187	Peptidase family M20/M25/M40
MC28_RS10785	COG1414	Transcriptional regulator
MC28_RS10790	COG0833	amino acid
MC28_RS10800	COG3239	Fatty acid desaturase
MC28_RS10810	COG1785	Belongs to the alkaline phosphatase family
MC28_RS10820	COG3655	Transcriptional regulator
MC28_RS10845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS10850	COG0346	lactoylglutathione lyase activity
MC28_RS10870	COG0714	Associated with various cellular activities
MC28_RS10895	COG0753	catalase activity
MC28_RS10935	COG0714	Associated with various cellular activities
MC28_RS10980	COG0778	Nitroreductase
MC28_RS10985	COG1846	Transcriptional regulator
MC28_RS11005	COG2312	Erythromycin esterase
MC28_RS11010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_RS11030	COG0456	acetyltransferase
MC28_RS11050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS11070	COG0642	Histidine kinase
MC28_RS11075	COG0745	RESPONSE REGULATOR receiver
MC28_RS11080	COG0596	Alpha beta hydrolase
MC28_RS11110	COG0730	response to heat
MC28_RS11120	COG0833	amino acid
MC28_RS11130	COG4335	DNA alkylation repair
MC28_RS11160	COG0768	penicillin binding
MC28_RS11190	COG1984	allophanate hydrolase subunit 2
MC28_RS11195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MC28_RS11200	COG1414	Transcriptional regulator
MC28_RS11215	COG3142	Participates in the control of copper homeostasis
MC28_RS11225	COG0640	Transcriptional regulator
MC28_RS11235	COG1960	acyl-CoA dehydrogenase activity
MC28_RS11250	COG3314	Sporulation integral membrane protein YlbJ
MC28_RS11280	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MC28_RS11300	COG0574	Belongs to the PEP-utilizing enzyme family
MC28_RS11300	COG3848	Pyruvate phosphate dikinase
MC28_RS11315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC28_RS11325	COG1876	peptidase activity
MC28_RS11330	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS11335	COG2267	carboxylic ester hydrolase activity
MC28_RS11340	COG1335	isochorismatase
MC28_RS11360	COG0583	DNA-binding transcription factor activity
MC28_RS11375	COG0598	Magnesium transport protein CorA
MC28_RS11415	COG0415	Belongs to the DNA photolyase family
MC28_RS11420	COG0288	reversible hydration of carbon dioxide
MC28_RS11430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC28_RS11435	COG5609	conserved protein (DUF2294)
MC28_RS11450	COG0697	spore germination
MC28_RS11460	COG1575	Belongs to the MenA family. Type 1 subfamily
MC28_RS11490	COG0798	PFAM Bile acid sodium symporter
MC28_RS11495	COG0346	lactoylglutathione lyase activity
MC28_RS11500	COG0640	Transcriptional regulator
MC28_RS11520	COG1309	transcriptional regulator
MC28_RS11530	COG2186	Transcriptional regulator
MC28_RS11545	COG0814	amino acid
MC28_RS11550	COG0697	spore germination
MC28_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS11565	COG1522	sequence-specific DNA binding
MC28_RS11580	COG0346	lactoylglutathione lyase activity
MC28_RS11640	COG0384	phenazine biosynthesis protein PhzF
MC28_RS11645	COG2814	Major facilitator Superfamily
MC28_RS11650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MC28_RS11675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS11680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_RS11690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_RS11715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MC28_RS11735	COG0577	efflux transmembrane transporter activity
MC28_RS11745	COG3850	Histidine kinase
MC28_RS11745	COG5002	protein histidine kinase activity
MC28_RS11755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS11765	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_RS11785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC28_RS11830	COG2814	Major facilitator Superfamily
MC28_RS11855	COG5444	nuclease activity
MC28_RS11890	COG1876	peptidase activity
MC28_RS11895	COG2843	Capsule synthesis protein
MC28_RS11905	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_RS11910	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS11920	COG0534	Mate efflux family protein
MC28_RS11930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_RS11945	COG0477	Major facilitator Superfamily
MC28_RS11960	COG1846	Transcriptional regulator
MC28_RS11965	COG2814	Major facilitator Superfamily
MC28_RS11985	COG1136	(ABC) transporter
MC28_RS12015	COG2031	fatty acid transporter
MC28_RS12025	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_RS12085	COG1288	antiporter activity
MC28_RS12090	COG2356	endonuclease I
MC28_RS12100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_RS12105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC28_RS12125	COG1733	regulation of RNA biosynthetic process
MC28_RS12130	COG0778	Nitroreductase
MC28_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS12175	COG1131	(ABC) transporter
MC28_RS12200	COG1011	Hydrolase
MC28_RS12210	COG2365	Tyrosine phosphatase family
MC28_RS12235	COG0346	lactoylglutathione lyase activity
MC28_RS12240	COG1940	carbohydrate kinase activity
MC28_RS12245	COG0738	Major facilitator superfamily
MC28_RS12250	COG0110	maltose O-acetyltransferase activity
MC28_RS12265	COG0628	permease
MC28_RS12300	COG0477	Major facilitator Superfamily
MC28_RS12315	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MC28_RS12325	COG1253	flavin adenine dinucleotide binding
MC28_RS12330	COG0789	Transcriptional regulator
MC28_RS12365	COG0697	spore germination
MC28_RS12370	COG1357	PFAM Pentapeptide repeats (8 copies)
MC28_RS12375	COG3813	Protein conserved in bacteria
MC28_RS12380	COG2706	6-phosphogluconolactonase activity
MC28_RS12385	COG1070	Carbohydrate kinase
MC28_RS12400	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MC28_RS12410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MC28_RS12415	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MC28_RS12420	COG0604	alcohol dehydrogenase
MC28_RS12425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_RS12440	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS12455	COG0840	transmembrane signaling receptor activity
MC28_RS12465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_RS12465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_RS12470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC28_RS12470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC28_RS12475	COG1733	regulation of RNA biosynthetic process
MC28_RS12490	COG0656	L-ascorbic acid biosynthetic process
MC28_RS12495	COG2814	Major facilitator Superfamily
MC28_RS12515	COG1846	Transcriptional regulator
MC28_RS12520	COG2824	Alkylphosphonate utilization operon protein PhnA
MC28_RS12525	COG0659	secondary active sulfate transmembrane transporter activity
MC28_RS12540	COG0814	amino acid
MC28_RS12545	COG3655	Transcriptional regulator
MC28_RS12575	COG1393	Belongs to the ArsC family
MC28_RS12580	COG1733	regulation of RNA biosynthetic process
MC28_RS12585	COG2188	Transcriptional regulator
MC28_RS12590	COG0673	inositol 2-dehydrogenase activity
MC28_RS12595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MC28_RS12600	COG1733	regulation of RNA biosynthetic process
MC28_RS12610	COG1733	regulation of RNA biosynthetic process
MC28_RS12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS12660	COG0384	phenazine biosynthesis protein PhzF
MC28_RS12680	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS12685	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_RS12690	COG1733	regulation of RNA biosynthetic process
MC28_RS12715	COG1191	sigma factor activity
MC28_RS12725	COG1280	lysine exporter protein (LysE YggA)
MC28_RS12775	COG1151	hydroxylamine reductase activity
MC28_RS12785	COG3757	hydrolase, family 25
MC28_RS12785	COG3409	Peptidoglycan-binding domain 1 protein
MC28_RS12820	COG2072	flavoprotein involved in K transport
MC28_RS12855	COG0604	alcohol dehydrogenase
MC28_RS12860	COG1113	amino acid transport
MC28_RS12865	COG0456	acetyltransferase
MC28_RS12870	COG2814	Major facilitator Superfamily
MC28_RS12920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_RS12925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_RS12935	COG1247	-acetyltransferase
MC28_RS12940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS12945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS12950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS12955	COG3739	integral membrane protein
MC28_RS12985	COG0583	DNA-binding transcription factor activity
MC28_RS13005	COG1193	negative regulation of DNA recombination
MC28_RS13015	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MC28_RS13020	COG1164	Oligoendopeptidase f
MC28_RS13045	COG3781	membrane
MC28_RS13060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_RS13075	COG0583	DNA-binding transcription factor activity
MC28_RS13090	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_RS13105	COG0640	Transcriptional regulator
MC28_RS13110	COG0604	alcohol dehydrogenase
MC28_RS13120	COG0457	Tetratricopeptide repeat
MC28_RS13130	COG2808	Putative FMN-binding domain
MC28_RS13135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MC28_RS13145	COG0277	FAD linked oxidase domain protein
MC28_RS13160	COG3858	chitin binding
MC28_RS13170	COG3300	MHYT domain
MC28_RS13170	COG5001	Diguanylate cyclase
MC28_RS13180	COG1876	peptidase activity
MC28_RS13210	COG2801	Transposase and inactivated derivatives
MC28_RS13220	COG3852	Histidine kinase
MC28_RS13230	COG1285	pathogenesis
MC28_RS13240	COG2514	catechol 2,3-dioxygenase activity
MC28_RS13245	COG2720	vancomycin resistance protein
MC28_RS13280	COG0716	FMN binding
MC28_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS13320	COG0165	Argininosuccinate lyase
MC28_RS13335	COG4145	pantothenate transmembrane transporter activity
MC28_RS13345	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS13360	COG1657	PFAM Prenyltransferase squalene oxidase
MC28_RS13365	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MC28_RS13370	COG2962	Rard protein
MC28_RS13375	COG3326	Membrane
MC28_RS13390	COG0489	protein tyrosine kinase activity
MC28_RS13400	COG0314	molybdopterin synthase activity
MC28_RS13405	COG0303	'Molybdopterin
MC28_RS13410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_RS13415	COG2116	formate transmembrane transporter activity
MC28_RS13425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC28_RS13430	COG5609	conserved protein (DUF2294)
MC28_RS13435	COG2427	Protein of unknown function (DUF1641)
MC28_RS13440	COG3383	formate dehydrogenase (NAD+) activity
MC28_RS13450	COG0697	spore germination
MC28_RS13465	COG0531	amino acid
MC28_RS13500	COG2226	methyltransferase
MC28_RS13505	COG4166	transmembrane transport
MC28_RS13510	COG4166	transmembrane transport
MC28_RS13515	COG4166	transmembrane transport
MC28_RS13520	COG1301	dicarboxylic acid transport
MC28_RS13525	COG1316	TRANSCRIPTIONal
MC28_RS13535	COG1595	DNA-templated transcription, initiation
MC28_RS13545	COG1131	(ABC) transporter
MC28_RS13555	COG0673	inositol 2-dehydrogenase activity
MC28_RS13560	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MC28_RS13565	COG0187	DNA topoisomerase II activity
MC28_RS13570	COG1832	CoA-binding protein
MC28_RS13575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_RS13580	COG0745	RESPONSE REGULATOR receiver
MC28_RS13590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC28_RS13590	COG1328	CTP reductase activity
MC28_RS13600	COG4841	protein insertion into membrane
MC28_RS13605	COG0824	Thioesterase
MC28_RS13630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_RS13640	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MC28_RS13645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MC28_RS13675	COG2211	Major facilitator Superfamily
MC28_RS13685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MC28_RS13700	COG0183	Belongs to the thiolase family
MC28_RS13705	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS13710	COG1268	BioY protein
MC28_RS13715	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS13720	COG1396	sequence-specific DNA binding
MC28_RS13760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS13770	COG5002	protein histidine kinase activity
MC28_RS13775	COG0400	carboxylic ester hydrolase activity
MC28_RS13780	COG0346	lactoylglutathione lyase activity
MC28_RS13785	COG0069	glutamate synthase activity
MC28_RS13790	COG1902	pentaerythritol trinitrate reductase activity
MC28_RS13795	COG1329	Transcriptional regulator
MC28_RS13800	COG0010	Belongs to the arginase family
MC28_RS13850	COG4846	Membrane protein involved in cytochrome C biogenesis
MC28_RS13855	COG0785	Cytochrome C biogenesis protein
MC28_RS13865	COG1473	amidohydrolase
MC28_RS13875	COG1131	(ABC) transporter
MC28_RS13890	COG0583	DNA-binding transcription factor activity
MC28_RS13900	COG1346	cytolysis
MC28_RS13915	COG0730	response to heat
MC28_RS13945	COG1132	(ABC) transporter
MC28_RS13950	COG1132	(ABC) transporter
MC28_RS13955	COG3763	UPF0154 protein
MC28_RS13975	COG3639	organic phosphonate transmembrane transporter activity
MC28_RS13990	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS14000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MC28_RS14020	COG1695	Transcriptional regulator
MC28_RS14025	COG1132	(ABC) transporter
MC28_RS14055	COG0367	asparagine synthase
MC28_RS14060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC28_RS14070	COG1181	Belongs to the D-alanine--D-alanine ligase family
MC28_RS14075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MC28_RS14105	COG0438	transferase activity, transferring glycosyl groups
MC28_RS14115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MC28_RS14115	COG0463	Glycosyl transferase, family 2
MC28_RS14120	COG0438	transferase activity, transferring glycosyl groups
MC28_RS14125	COG0438	transferase activity, transferring glycosyl groups
MC28_RS14130	COG1086	Polysaccharide biosynthesis protein
MC28_RS14135	COG0489	protein tyrosine kinase activity
MC28_RS14145	COG0174	glutamine synthetase
MC28_RS14150	COG0789	Transcriptional regulator
MC28_RS14155	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MC28_RS14160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC28_RS14165	COG2860	membrane
MC28_RS14175	COG0464	growth
MC28_RS14205	COG2801	Transposase and inactivated derivatives
MC28_RS14225	COG1388	LysM domain
MC28_RS14225	COG3584	3D domain protein
MC28_RS14230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_RS14230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_RS14230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_RS14235	COG1105	Belongs to the carbohydrate kinase PfkB family
MC28_RS14240	COG1349	DNA-binding transcription factor activity
MC28_RS14245	COG1979	alcohol dehydrogenase
MC28_RS14250	COG2322	membrane
MC28_RS14265	COG1113	amino acid transport
MC28_RS14275	COG1473	amidohydrolase
MC28_RS14280	COG1408	metallophosphoesterase
MC28_RS14295	COG2217	Heavy metal translocating P-type atpase
MC28_RS14300	COG2608	mercury ion transmembrane transporter activity
MC28_RS14305	COG1937	Protein conserved in bacteria
MC28_RS14325	COG2819	hydrolase of the alpha beta superfamily
MC28_RS14330	COG1120	ATPase activity
MC28_RS14335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS14340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS14345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS14350	COG0708	Exodeoxyribonuclease III
MC28_RS14355	COG2169	Transcriptional regulator
MC28_RS14360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC28_RS14365	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MC28_RS14375	COG2364	Membrane
MC28_RS14395	COG5001	Diguanylate cyclase
MC28_RS14395	COG3300	MHYT domain
MC28_RS14435	COG1346	cytolysis
MC28_RS14445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS14450	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_RS14450	COG0596	Alpha beta hydrolase
MC28_RS14455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_RS14465	COG2188	Transcriptional regulator
MC28_RS14470	COG2723	6-phospho-beta-galactosidase activity
MC28_RS14480	COG1404	Belongs to the peptidase S8 family
MC28_RS14485	COG3773	Cell wall hydrolase
MC28_RS14495	COG1368	sulfuric ester hydrolase activity
MC28_RS14525	COG4550	Control of competence regulator ComK, YlbF/YmcA
MC28_RS14535	COG1013	pyruvate-flavodoxin oxidoreductase activity
MC28_RS14540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MC28_RS14540	COG0674	pyruvate-flavodoxin oxidoreductase activity
MC28_RS14550	COG2359	stage V sporulation protein S
MC28_RS14555	COG1692	metallophosphoesterase
MC28_RS14590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC28_RS14595	COG1426	Protein conserved in bacteria
MC28_RS14610	COG0300	oxidoreductase activity
MC28_RS14615	COG0612	Peptidase, M16
MC28_RS14620	COG0612	Peptidase, M16
MC28_RS14625	COG1079	Belongs to the binding-protein-dependent transport system permease family
MC28_RS14630	COG4603	Belongs to the binding-protein-dependent transport system permease family
MC28_RS14635	COG3845	ABC transporter
MC28_RS14640	COG1744	ABC transporter substrate-binding protein PnrA-like
MC28_RS14645	COG2188	Transcriptional regulator
MC28_RS14650	COG1674	ftsk spoiiie
MC28_RS14660	COG0740	serine-type endopeptidase activity
MC28_RS14665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MC28_RS14675	COG0527	aspartate kinase activity
MC28_RS14680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC28_RS14685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC28_RS14705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC28_RS14735	COG5632	N-Acetylmuramoyl-L-alanine amidase
MC28_RS14805	COG0740	serine-type endopeptidase activity
MC28_RS14845	COG1388	LysM domain
MC28_RS14845	COG3584	3D domain protein
MC28_RS14855	COG0582	viral genome integration into host DNA
MC28_RS14895	COG0305	Participates in initiation and elongation during chromosome replication
MC28_RS14930	COG1396	sequence-specific DNA binding
MC28_RS14950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC28_RS14955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_RS14960	COG1873	PFAM PRC-barrel domain
MC28_RS14965	COG0612	Peptidase, M16
MC28_RS14970	COG0726	polysaccharide deacetylase
MC28_RS14985	COG0196	riboflavin kinase activity
MC28_RS14995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MC28_RS15010	COG1358	cellular component organization or biogenesis
MC28_RS15015	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MC28_RS15020	COG0195	Participates in both transcription termination and antitermination
MC28_RS15040	COG0750	zinc metalloprotease
MC28_RS15050	COG4589	Belongs to the CDS family
MC28_RS15065	COG0528	UMP kinase activity
MC28_RS15070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MC28_RS15095	COG4974	Belongs to the 'phage' integrase family
MC28_RS15105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC28_RS15110	COG0758	DNA mediated transformation
MC28_RS15115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MC28_RS15140	COG0335	large ribosomal subunit rRNA binding
MC28_RS15155	COG1837	Belongs to the UPF0109 family
MC28_RS15165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MC28_RS15175	COG0552	protein localization to endoplasmic reticulum
MC28_RS15180	COG1196	nuclear chromosome segregation
MC28_RS15190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC28_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS15200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MC28_RS15215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MC28_RS15220	COG1461	Dihydroxyacetone kinase
MC28_RS15225	COG1302	Protein conserved in bacteria
MC28_RS15240	COG1564	THIamine pyrophosphokinase
MC28_RS15245	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MC28_RS15250	COG1162	GTPase activity
MC28_RS15255	COG2815	serine threonine protein kinase
MC28_RS15255	COG0515	serine threonine protein kinase
MC28_RS15260	COG0631	protein serine/threonine phosphatase activity
MC28_RS15270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC28_RS15270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC28_RS15275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC28_RS15285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MC28_RS15290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC28_RS15310	COG1561	YicC-like family, N-terminal region
MC28_RS15315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MC28_RS15325	COG0006	proline dipeptidase activity
MC28_RS15345	COG3069	C4-dicarboxylate transmembrane transporter activity
MC28_RS15405	COG0564	pseudouridine synthase activity
MC28_RS15425	COG3599	regulation of cell shape
MC28_RS15430	COG2302	S4 RNA-binding domain
MC28_RS15435	COG0762	integral membrane protein
MC28_RS15445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MC28_RS15455	COG1873	PFAM PRC-barrel domain
MC28_RS15460	COG1191	sigma factor activity
MC28_RS15465	COG1191	sigma factor activity
MC28_RS15475	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MC28_RS15480	COG0849	cell division
MC28_RS15485	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MC28_RS15500	COG0772	Belongs to the SEDS family
MC28_RS15520	COG0768	penicillin binding
MC28_RS15525	COG0768	penicillin binding
MC28_RS15545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MC28_RS15560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MC28_RS15565	COG1399	metal-binding, possibly nucleic acid-binding protein
MC28_RS15610	COG4824	toxin secretion phage lysis holin
MC28_RS15695	COG0740	serine-type endopeptidase activity
MC28_RS15705	COG1802	Transcriptional regulator
MC28_RS15705	COG4626	Terminase
MC28_RS15740	COG0582	viral genome integration into host DNA
MC28_RS15830	COG2002	toxin-antitoxin pair type II binding
MC28_RS15855	COG1396	sequence-specific DNA binding
MC28_RS15885	COG0582	viral genome integration into host DNA
MC28_RS15895	COG3480	Lon protease (S16) C-terminal proteolytic domain
MC28_RS15900	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC28_RS15905	COG3314	Sporulation integral membrane protein YlbJ
MC28_RS15915	COG0742	ribosomal rna small subunit methyltransferase
MC28_RS15930	COG3679	Belongs to the UPF0342 family
MC28_RS15935	COG0406	alpha-ribazole phosphatase activity
MC28_RS15950	COG2340	Cysteine-rich secretory protein family
MC28_RS15965	COG3336	cytochrome c oxidase
MC28_RS16000	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MC28_RS16005	COG0772	Belongs to the SEDS family
MC28_RS16015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MC28_RS16020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MC28_RS16030	COG4896	Protein conserved in bacteria
MC28_RS16045	COG1217	gtp-binding protein TYPA
MC28_RS16055	COG0483	inositol monophosphate 1-phosphatase activity
MC28_RS16075	COG1982	Orn Lys Arg decarboxylase major
MC28_RS16135	COG0022	dehydrogenase e1 component
MC28_RS16140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC28_RS16150	COG0242	peptide deformylase activity
MC28_RS16155	COG0561	phosphatase activity
MC28_RS16160	COG5503	Protein of unknown function (DUF1447)
MC28_RS16165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MC28_RS16170	COG0569	domain protein
MC28_RS16185	COG2171	N-acyltransferase activity
MC28_RS16190	COG0583	DNA-binding transcription factor activity
MC28_RS16195	COG0517	IMP dehydrogenase activity
MC28_RS16205	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MC28_RS16215	COG4703	Protein of unknown function (DUF1797)
MC28_RS16235	COG2200	EAL domain
MC28_RS16240	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS16245	COG1408	metallophosphoesterase
MC28_RS16255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MC28_RS16290	COG2814	Major facilitator Superfamily
MC28_RS16310	COG3209	COG3209 Rhs family protein
MC28_RS16320	COG2205	protein histidine kinase activity
MC28_RS16330	COG0436	Aminotransferase
MC28_RS16335	COG1609	Transcriptional regulator
MC28_RS16340	COG3833	ABC-type maltose transport systems, permease component
MC28_RS16345	COG1175	transmembrane transport
MC28_RS16350	COG2182	Extracellular solute-binding protein
MC28_RS16360	COG0366	Alpha amylase catalytic
MC28_RS16365	COG3842	ATPase activity
MC28_RS16405	COG0183	Belongs to the thiolase family
MC28_RS16435	COG1695	Transcriptional regulator
MC28_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS16455	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MC28_RS16460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC28_RS16465	COG0436	Aminotransferase
MC28_RS16500	COG2084	Dehydrogenase
MC28_RS16510	COG2199	diguanylate cyclase activity
MC28_RS16515	COG0778	Nitroreductase
MC28_RS16540	COG1263	PTS System
MC28_RS16540	COG2190	(PTS) system
MC28_RS16540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS16545	COG3711	transcriptional antiterminator
MC28_RS16555	COG2188	Transcriptional regulator
MC28_RS16565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC28_RS16585	COG1547	Domain of unknown function (DUF309)
MC28_RS16590	COG0456	acetyltransferase
MC28_RS16595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC28_RS16600	COG4086	secreted protein
MC28_RS16605	COG0561	phosphatase activity
MC28_RS16610	COG0697	spore germination
MC28_RS16625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_RS16650	COG0733	neurotransmitter:sodium symporter activity
MC28_RS16670	COG1686	Belongs to the peptidase S11 family
MC28_RS16675	COG1725	Transcriptional regulator
MC28_RS16680	COG1131	(ABC) transporter
MC28_RS16700	COG1846	Transcriptional regulator
MC28_RS16715	COG0598	Magnesium transport protein CorA
MC28_RS16740	COG4974	Belongs to the 'phage' integrase family
MC28_RS16750	COG0735	belongs to the Fur family
MC28_RS16755	COG1300	Membrane
MC28_RS16775	COG0667	Aldo Keto reductase
MC28_RS16780	COG0656	L-ascorbic acid biosynthetic process
MC28_RS16785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MC28_RS16785	COG0456	acetyltransferase
MC28_RS16795	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS16795	COG1525	nuclease
MC28_RS16795	COG4085	toxin activity
MC28_RS16805	COG0596	Alpha beta hydrolase
MC28_RS16810	COG2056	Na+-H+ antiporter family
MC28_RS16815	COG1609	Transcriptional regulator
MC28_RS16820	COG0456	acetyltransferase
MC28_RS16825	COG1073	alpha beta
MC28_RS16840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_RS16840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_RS16845	COG0307	riboflavin synthase, alpha
MC28_RS16870	COG4106	trans-aconitate 2-methyltransferase activity
MC28_RS16875	COG2226	methyltransferase
MC28_RS16875	COG1073	alpha beta
MC28_RS16890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_RS16900	COG1757	Na H antiporter
MC28_RS16905	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS16915	COG1522	sequence-specific DNA binding
MC28_RS16950	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MC28_RS16960	COG0300	oxidoreductase activity
MC28_RS16965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS16970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_RS16975	COG1760	l-serine dehydratase
MC28_RS16980	COG1760	l-serine dehydratase
MC28_RS17010	COG1285	pathogenesis
MC28_RS17020	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC28_RS17025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS17035	COG1376	ErfK ybiS ycfS ynhG family protein
MC28_RS17040	COG4129	membrane
MC28_RS17045	COG1126	abc transporter atp-binding protein
MC28_RS17050	COG0765	amino acid transport
MC28_RS17055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_RS17075	COG2323	membrane
MC28_RS17080	COG0772	Belongs to the SEDS family
MC28_RS17085	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_RS17090	COG0022	dehydrogenase e1 component
MC28_RS17095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC28_RS17100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC28_RS17115	COG0280	phosphate acetyltransferase
MC28_RS17120	COG3290	protein histidine kinase activity
MC28_RS17120	COG3829	transcription factor binding
MC28_RS17130	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_RS17135	COG3093	addiction module antidote protein HigA
MC28_RS17140	COG1215	transferase activity, transferring glycosyl groups
MC28_RS17150	COG0745	RESPONSE REGULATOR receiver
MC28_RS17155	COG0750	zinc metalloprotease
MC28_RS17160	COG0497	DNA recombination
MC28_RS17170	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MC28_RS17180	COG0142	geranyltranstransferase activity
MC28_RS17200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC28_RS17205	COG1302	Protein conserved in bacteria
MC28_RS17210	COG0439	Biotin carboxylase
MC28_RS17215	COG0511	ligase activity, forming carbon-carbon bonds
MC28_RS17260	COG3854	ATPases associated with a variety of cellular activities
MC28_RS17285	COG0006	proline dipeptidase activity
MC28_RS17300	COG3872	metal-dependent enzyme
MC28_RS17310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC28_RS17340	COG0095	Lipoate-protein ligase
MC28_RS17345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS17355	COG1609	Transcriptional regulator
MC28_RS17365	COG2076	Multidrug Resistance protein
MC28_RS17370	COG2076	Multidrug Resistance protein
MC28_RS17400	COG1131	(ABC) transporter
MC28_RS17405	COG1725	Transcriptional regulator
MC28_RS17420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MC28_RS17430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MC28_RS17435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_RS17490	COG4970	Tfp pilus assembly protein FimT
MC28_RS17500	COG1459	type II secretion system
MC28_RS17505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC28_RS17560	COG1410	methionine synthase
MC28_RS17560	COG0646	methionine synthase
MC28_RS17565	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MC28_RS17565	COG0646	methionine synthase
MC28_RS17570	COG0626	cystathionine gamma-synthase activity
MC28_RS17575	COG0626	cystathionine gamma-synthase activity
MC28_RS17600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS17610	COG1940	carbohydrate kinase activity
MC28_RS17615	COG4483	Protein conserved in bacteria
MC28_RS17620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MC28_RS17625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MC28_RS17630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MC28_RS17635	COG0704	Plays a role in the regulation of phosphate uptake
MC28_RS17645	COG0581	inorganic phosphate transmembrane transporter activity
MC28_RS17650	COG0573	inorganic phosphate transmembrane transporter activity
MC28_RS17655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MC28_RS17660	COG0768	penicillin binding
MC28_RS17665	COG0477	Major facilitator Superfamily
MC28_RS17670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_RS17695	COG0735	belongs to the Fur family
MC28_RS17700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC28_RS17705	COG1121	(ABC) transporter
MC28_RS17710	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS17740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MC28_RS17745	COG2384	SAM-dependent methyltransferase
MC28_RS17750	COG2010	Cytochrome c
MC28_RS17755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC28_RS17760	COG0358	DNA primase activity
MC28_RS17765	COG1671	Belongs to the UPF0178 family
MC28_RS17775	COG0517	IMP dehydrogenase activity
MC28_RS17790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MC28_RS17795	COG0295	cytidine deaminase activity
MC28_RS17800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MC28_RS17805	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MC28_RS17810	COG1480	7TM receptor with intracellular HD hydrolase
MC28_RS17815	COG1702	phosphate starvation-inducible protein PhoH
MC28_RS17830	COG1610	YqeY-like protein
MC28_RS17835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MC28_RS17840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC28_RS17845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MC28_RS17855	COG0484	heat shock protein binding
MC28_RS17870	COG1420	regulation of RNA biosynthetic process
MC28_RS17875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC28_RS17880	COG1733	regulation of RNA biosynthetic process
MC28_RS17905	COG1466	dna polymerase III delta subunit
MC28_RS17915	COG0658	competence protein
MC28_RS17915	COG2333	competence protein COMEC
MC28_RS17920	COG2131	deaminase
MC28_RS17925	COG1555	photosystem II stabilization
MC28_RS17925	COG1596	polysaccharide export
MC28_RS17930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_RS17935	COG2226	methyltransferase
MC28_RS17940	COG0799	negative regulation of ribosome biogenesis
MC28_RS17945	COG1713	HD superfamily hydrolase involved in NAD metabolism
MC28_RS17950	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MC28_RS17955	COG1534	Rna-binding protein
MC28_RS17965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MC28_RS17970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MC28_RS18005	COG0778	Nitroreductase
MC28_RS18010	COG2357	RelA SpoT domain protein
MC28_RS18020	COG1785	Belongs to the alkaline phosphatase family
MC28_RS18030	COG2267	carboxylic ester hydrolase activity
MC28_RS18065	COG1404	Belongs to the peptidase S8 family
MC28_RS18070	COG3186	Phenylalanine-4-hydroxylase
MC28_RS18080	COG2514	catechol 2,3-dioxygenase activity
MC28_RS18085	COG2259	Doxx family
MC28_RS18125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS18135	COG1454	alcohol dehydrogenase
MC28_RS18135	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS18140	COG0626	cystathionine gamma-synthase activity
MC28_RS18145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_RS18170	COG0768	penicillin binding
MC28_RS18185	COG0826	peptidase U32
MC28_RS18190	COG0826	peptidase U32
MC28_RS18195	COG4122	O-methyltransferase activity
MC28_RS18200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MC28_RS18215	COG4472	Bacterial protein of unknown function (DUF965)
MC28_RS18230	COG0628	permease
MC28_RS18250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MC28_RS18265	COG1104	cysteine desulfurase activity
MC28_RS18270	COG1959	2 iron, 2 sulfur cluster binding
MC28_RS18275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MC28_RS18285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MC28_RS18320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC28_RS18330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MC28_RS18330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MC28_RS18335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC28_RS18340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC28_RS18340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC28_RS18350	COG2244	polysaccharide biosynthetic process
MC28_RS18355	COG2323	membrane
MC28_RS18365	COG1862	Preprotein translocase
MC28_RS18370	COG0343	queuine tRNA-ribosyltransferase activity
MC28_RS18385	COG2255	four-way junction helicase activity
MC28_RS18390	COG0632	four-way junction helicase activity
MC28_RS18395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MC28_RS18425	COG0157	Belongs to the NadC ModD family
MC28_RS18430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MC28_RS18435	COG1104	cysteine desulfurase activity
MC28_RS18440	COG1827	regulation of RNA biosynthetic process
MC28_RS18445	COG2258	MOSC domain
MC28_RS18450	COG0077	Prephenate dehydratase
MC28_RS18455	COG0577	efflux transmembrane transporter activity
MC28_RS18460	COG0577	efflux transmembrane transporter activity
MC28_RS18465	COG1136	(ABC) transporter
MC28_RS18470	COG5002	protein histidine kinase activity
MC28_RS18475	COG0745	RESPONSE REGULATOR receiver
MC28_RS18485	COG3290	protein histidine kinase activity
MC28_RS18495	COG2868	ribosomal protein
MC28_RS18505	COG1530	ribonuclease E activity
MC28_RS18510	COG1994	Peptidase M50
MC28_RS18515	COG0739	heme binding
MC28_RS18520	COG2894	cell division
MC28_RS18540	COG1077	Cell shape determining protein MreB Mrl
MC28_RS18560	COG0285	dihydrofolate synthase activity
MC28_RS18575	COG1388	LysM domain
MC28_RS18585	COG0113	porphobilinogen synthase activity
MC28_RS18590	COG1587	Uroporphyrinogen-III synthase
MC28_RS18600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC28_RS18610	COG1846	Transcriptional regulator
MC28_RS18615	COG1764	response to oxidative stress
MC28_RS18630	COG1067	ATP-dependent peptidase activity
MC28_RS18630	COG0470	DNA polymerase III
MC28_RS18670	COG0622	Phosphoesterase
MC28_RS18685	COG5401	PFAM Sporulation and spore germination
MC28_RS18705	COG1309	transcriptional regulator
MC28_RS18715	COG2197	response regulator
MC28_RS18720	COG2233	PERMEase
MC28_RS18725	COG0402	S-adenosylhomocysteine deaminase activity
MC28_RS18730	COG1983	PspC domain protein
MC28_RS18735	COG1396	sequence-specific DNA binding
MC28_RS18740	COG0697	spore germination
MC28_RS18750	COG1959	2 iron, 2 sulfur cluster binding
MC28_RS18755	COG1668	transmembrane transport
MC28_RS18760	COG4152	abc transporter atp-binding protein
MC28_RS18765	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MC28_RS18770	COG1360	Flagellar Motor Protein
MC28_RS18775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC28_RS18780	COG1876	peptidase activity
MC28_RS18785	COG0824	Thioesterase
MC28_RS18790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MC28_RS18795	COG1053	succinate dehydrogenase
MC28_RS18800	COG2009	succinate dehydrogenase
MC28_RS18805	COG1719	4-vinyl reductase, 4VR
MC28_RS18810	COG0322	excinuclease ABC activity
MC28_RS18815	COG3118	belongs to the thioredoxin family
MC28_RS18820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MC28_RS18825	COG2086	electron transfer activity
MC28_RS18830	COG1024	Enoyl-CoA hydratase
MC28_RS18835	COG1309	transcriptional regulator
MC28_RS18840	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS18870	COG2318	DinB family
MC28_RS18895	COG1131	(ABC) transporter
MC28_RS18900	COG2205	protein histidine kinase activity
MC28_RS18905	COG0745	RESPONSE REGULATOR receiver
MC28_RS18915	COG4895	conserved protein (DUF2196)
MC28_RS18920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MC28_RS18930	COG4509	Sortase family
MC28_RS18935	COG1120	ATPase activity
MC28_RS18950	COG5386	Cell surface protein
MC28_RS18960	COG5386	Cell surface protein
MC28_RS18965	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS18970	COG1187	pseudouridine synthase activity
MC28_RS18980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC28_RS18980	COG1796	DNA polymerase
MC28_RS18985	COG1286	toxin biosynthetic process
MC28_RS18990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MC28_RS19020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC28_RS19030	COG1418	mRNA catabolic process
MC28_RS19045	COG2814	Major facilitator Superfamily
MC28_RS19050	COG1566	PFAM secretion protein HlyD family protein
MC28_RS19055	COG1309	transcriptional regulator
MC28_RS19060	COG1363	Peptidase, m42
MC28_RS19085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC28_RS19095	COG1484	DNA-dependent DNA replication
MC28_RS19100	COG3611	Membrane attachment protein
MC28_RS19110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MC28_RS19115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC28_RS19120	COG0237	dephospho-CoA kinase activity
MC28_RS19125	COG1971	Probably functions as a manganese efflux pump
MC28_RS19135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_RS19135	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_RS19140	COG5002	protein histidine kinase activity
MC28_RS19145	COG0745	RESPONSE REGULATOR receiver
MC28_RS19165	COG0538	isocitrate dehydrogenase activity
MC28_RS19170	COG0372	Belongs to the citrate synthase family
MC28_RS19180	COG0628	permease
MC28_RS19185	COG3030	protein affecting phage T7 exclusion by the F plasmid
MC28_RS19210	COG1725	Transcriptional regulator
MC28_RS19215	COG0281	malic enzyme
MC28_RS19220	COG0587	DNA-directed DNA polymerase activity
MC28_RS19235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MC28_RS19250	COG4109	DRTGG domain
MC28_RS19265	COG0006	proline dipeptidase activity
MC28_RS19300	COG0662	Cupin 2, conserved barrel domain protein
MC28_RS19315	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS19320	COG0589	response to stress
MC28_RS19325	COG0346	lactoylglutathione lyase activity
MC28_RS19365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS19390	COG0827	DNA restriction-modification system
MC28_RS19395	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MC28_RS19400	COG3874	Sporulation protein YtfJ
MC28_RS19415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MC28_RS19425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_RS19440	COG1104	cysteine desulfurase activity
MC28_RS19445	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MC28_RS19450	COG0583	DNA-binding transcription factor activity
MC28_RS19455	COG0697	spore germination
MC28_RS19460	COG1309	transcriptional regulator
MC28_RS19465	COG1956	GAF domain-containing protein
MC28_RS19470	COG0626	cystathionine gamma-synthase activity
MC28_RS19505	COG1595	DNA-templated transcription, initiation
MC28_RS19515	COG0110	maltose O-acetyltransferase activity
MC28_RS19520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_RS19525	COG0454	-acetyltransferase
MC28_RS19530	COG0517	IMP dehydrogenase activity
MC28_RS19535	COG0123	including yeast histone deacetylase and acetoin utilization protein
MC28_RS19550	COG0745	RESPONSE REGULATOR receiver
MC28_RS19555	COG5002	protein histidine kinase activity
MC28_RS19560	COG0666	response to abiotic stimulus
MC28_RS19590	COG1609	Transcriptional regulator
MC28_RS19595	COG1605	Chorismate mutase
MC28_RS19595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MC28_RS19600	COG4851	CamS sex pheromone cAM373 precursor
MC28_RS19605	COG3118	belongs to the thioredoxin family
MC28_RS19615	COG2309	aminopeptidase activity
MC28_RS19635	COG0697	spore germination
MC28_RS19640	COG0789	Transcriptional regulator
MC28_RS19655	COG1674	ftsk spoiiie
MC28_RS19660	COG1388	LysM domain
MC28_RS19660	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_RS19670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC28_RS19675	COG4848	Belongs to the UPF0354 family
MC28_RS19680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_RS19685	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MC28_RS19690	COG1363	Peptidase, m42
MC28_RS19700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS19715	COG0510	thiamine kinase activity
MC28_RS19720	COG1523	belongs to the glycosyl hydrolase 13 family
MC28_RS19730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_RS19735	COG1349	DNA-binding transcription factor activity
MC28_RS19740	COG1187	pseudouridine synthase activity
MC28_RS19745	COG2244	polysaccharide biosynthetic process
MC28_RS19750	COG2081	HI0933 family
MC28_RS19755	COG2814	Major facilitator Superfamily
MC28_RS19765	COG3832	glyoxalase III activity
MC28_RS19785	COG1329	Transcriptional regulator
MC28_RS19810	COG0314	molybdopterin synthase activity
MC28_RS19815	COG1763	Mo-molybdopterin cofactor biosynthetic process
MC28_RS19820	COG0303	'Molybdopterin
MC28_RS19830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_RS19835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC28_RS19855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS19865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MC28_RS19910	COG2814	Major facilitator Superfamily
MC28_RS19915	COG0475	glutathione-regulated potassium exporter activity
MC28_RS19920	COG0490	domain, Protein
MC28_RS19925	COG0582	viral genome integration into host DNA
MC28_RS19940	COG1136	(ABC) transporter
MC28_RS19960	COG1242	4 iron, 4 sulfur cluster binding
MC28_RS19965	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MC28_RS19980	COG1253	flavin adenine dinucleotide binding
MC28_RS20005	COG0656	L-ascorbic acid biosynthetic process
MC28_RS20030	COG2267	carboxylic ester hydrolase activity
MC28_RS20035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MC28_RS20040	COG0671	phosphoesterase, PA-phosphatase related
MC28_RS20045	COG0438	transferase activity, transferring glycosyl groups
MC28_RS20100	COG3852	Histidine kinase
MC28_RS20105	COG3852	Histidine kinase
MC28_RS20110	COG0753	catalase activity
MC28_RS20115	COG2267	carboxylic ester hydrolase activity
MC28_RS20120	COG1368	sulfuric ester hydrolase activity
MC28_RS20135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_RS20140	COG1116	anion transmembrane transporter activity
MC28_RS20145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_RS20170	COG0494	nUDIX hydrolase
MC28_RS20195	COG1854	S-ribosylhomocysteine lyase activity
MC28_RS20205	COG0288	reversible hydration of carbon dioxide
MC28_RS20210	COG1271	oxidase subunit
MC28_RS20215	COG1294	oxidase, subunit
MC28_RS20230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS20255	COG1842	Phage shock protein A
MC28_RS20285	COG5002	protein histidine kinase activity
MC28_RS20290	COG0745	RESPONSE REGULATOR receiver
MC28_RS20315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MC28_RS20320	COG1597	lipid kinase activity
MC28_RS20340	COG0577	efflux transmembrane transporter activity
MC28_RS20345	COG1136	(ABC) transporter
MC28_RS20370	COG0586	Pfam SNARE associated Golgi protein
MC28_RS20375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MC28_RS20380	COG0577	efflux transmembrane transporter activity
MC28_RS20385	COG1136	(ABC) transporter
MC28_RS20390	COG2207	Transcriptional regulator
MC28_RS20390	COG3708	Transcriptional regulator
MC28_RS20400	COG1131	(ABC) transporter
MC28_RS20405	COG5658	integral membrane protein
MC28_RS20410	COG0640	Transcriptional regulator
MC28_RS20420	COG1595	DNA-templated transcription, initiation
MC28_RS20425	COG0745	RESPONSE REGULATOR receiver
MC28_RS20430	COG2205	protein histidine kinase activity
MC28_RS20435	COG0577	efflux transmembrane transporter activity
MC28_RS20440	COG0577	efflux transmembrane transporter activity
MC28_RS20445	COG1136	(ABC) transporter
MC28_RS20450	COG0577	efflux transmembrane transporter activity
MC28_RS20465	COG2188	Transcriptional regulator
MC28_RS20485	COG3964	amidohydrolase
MC28_RS20500	COG0745	RESPONSE REGULATOR receiver
MC28_RS20505	COG4948	Mandelate Racemase Muconate Lactonizing
MC28_RS20515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MC28_RS20520	COG0596	Alpha beta hydrolase
MC28_RS20530	COG1169	isochorismate synthase
MC28_RS20535	COG1575	Belongs to the MenA family. Type 1 subfamily
MC28_RS20540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MC28_RS20545	COG1278	Cold shock
MC28_RS20565	COG0058	SHG alpha-glucan phosphorylase activity
MC28_RS20575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MC28_RS20580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MC28_RS20595	COG1404	Belongs to the peptidase S8 family
MC28_RS20635	COG1285	pathogenesis
MC28_RS20640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC28_RS20655	COG2155	Conserved Protein
MC28_RS20660	COG1098	S1 RNA binding domain
MC28_RS20665	COG0436	Aminotransferase
MC28_RS20670	COG1522	sequence-specific DNA binding
MC28_RS20675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_RS20680	COG2267	carboxylic ester hydrolase activity
MC28_RS20690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MC28_RS20710	COG5018	Exonuclease
MC28_RS20715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_RS20735	COG2050	protein possibly involved in aromatic compounds catabolism
MC28_RS20745	COG1268	BioY protein
MC28_RS20750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC28_RS20755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC28_RS20770	COG3584	3D domain protein
MC28_RS20785	COG1252	NADH dehydrogenase
MC28_RS20795	COG3708	Transcriptional regulator
MC28_RS20810	COG1683	Conserved Protein
MC28_RS20830	COG0316	Belongs to the HesB IscA family
MC28_RS20845	COG1252	NADH dehydrogenase
MC28_RS20860	COG0390	transport system, permease component
MC28_RS20865	COG2824	Alkylphosphonate utilization operon protein PhnA
MC28_RS20885	COG4837	Protein of unknown function (DUF1462)
MC28_RS20890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MC28_RS20900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC28_RS20905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MC28_RS20925	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_RS20935	COG0647	UMP catabolic process
MC28_RS20945	COG2445	Protein of unknown function DUF86
MC28_RS20950	COG1494	fructose-1,6-bisphosphatase
MC28_RS20970	COG4470	Protein conserved in bacteria
MC28_RS20980	COG0789	Transcriptional regulator
MC28_RS20985	COG4377	Putative membrane peptidase family (DUF2324)
MC28_RS21010	COG0739	heme binding
MC28_RS21020	COG3377	Domain of unknown function (DUF1805)
MC28_RS21025	COG0737	Belongs to the 5'-nucleotidase family
MC28_RS21030	COG0719	Fe-S assembly protein
MC28_RS21035	COG0822	iron-sulfur transferase activity
MC28_RS21040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MC28_RS21045	COG0719	Fe-S assembly protein
MC28_RS21050	COG0396	ATPase activity
MC28_RS21055	COG1464	Belongs to the NlpA lipoprotein family
MC28_RS21060	COG1464	Belongs to the NlpA lipoprotein family
MC28_RS21065	COG2011	ABC-type metal ion transport system permease component
MC28_RS21080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_RS21085	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MC28_RS21095	COG1393	Belongs to the ArsC family
MC28_RS21125	COG0039	L-malate dehydrogenase activity
MC28_RS21145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS21150	COG1960	acyl-CoA dehydrogenase activity
MC28_RS21160	COG0183	Belongs to the thiolase family
MC28_RS21165	COG1024	Enoyl-CoA hydratase
MC28_RS21165	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC28_RS21175	COG1686	Belongs to the peptidase S11 family
MC28_RS21190	COG0011	TIGRFAM Protein of
MC28_RS21195	COG0840	transmembrane signaling receptor activity
MC28_RS21210	COG2814	Major facilitator Superfamily
MC28_RS21215	COG0531	amino acid
MC28_RS21235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS21265	COG0586	Pfam SNARE associated Golgi protein
MC28_RS21275	COG1376	ErfK ybiS ycfS ynhG family protein
MC28_RS21280	COG0745	RESPONSE REGULATOR receiver
MC28_RS21285	COG5002	protein histidine kinase activity
MC28_RS21305	COG0840	transmembrane signaling receptor activity
MC28_RS21310	COG0840	transmembrane signaling receptor activity
MC28_RS21315	COG2151	metal-sulfur cluster biosynthetic enzyme
MC28_RS21320	COG3227	Zinc metalloprotease (Elastase)
MC28_RS21340	COG0586	Pfam SNARE associated Golgi protein
MC28_RS21345	COG0475	glutathione-regulated potassium exporter activity
MC28_RS21350	COG0490	domain, Protein
MC28_RS21355	COG1115	amino acid carrier protein
MC28_RS21360	COG0783	Belongs to the Dps family
MC28_RS21380	COG1611	Belongs to the LOG family
MC28_RS21390	COG1528	Iron-storage protein
MC28_RS21395	COG2311	Membrane
MC28_RS21400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS21405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS21410	COG1115	amino acid carrier protein
MC28_RS21415	COG1115	amino acid carrier protein
MC28_RS21420	COG2910	NAD(P)H-binding
MC28_RS21435	COG0656	L-ascorbic acid biosynthetic process
MC28_RS21440	COG2814	Major facilitator Superfamily
MC28_RS21445	COG1733	regulation of RNA biosynthetic process
MC28_RS21455	COG1252	NADH dehydrogenase
MC28_RS21475	COG3290	protein histidine kinase activity
MC28_RS21475	COG0840	transmembrane signaling receptor activity
MC28_RS21485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MC28_RS21510	COG0488	(ABC) transporter
MC28_RS21515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_RS21530	COG1335	isochorismatase
MC28_RS21535	COG1522	sequence-specific DNA binding
MC28_RS21545	COG1522	sequence-specific DNA binding
MC28_RS21550	COG0288	reversible hydration of carbon dioxide
MC28_RS21555	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MC28_RS21560	COG2233	PERMEase
MC28_RS21600	COG0557	exoribonuclease II activity
MC28_RS21605	COG1647	Serine aminopeptidase, S33
MC28_RS21610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MC28_RS21615	COG1346	cytolysis
MC28_RS21650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC28_RS21665	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MC28_RS21700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_RS21715	COG2323	membrane
MC28_RS21725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_RS21735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MC28_RS21745	COG1051	belongs to the nudix hydrolase family
MC28_RS21755	COG0492	ferredoxin-NADP+ reductase activity
MC28_RS21760	COG0457	Tetratricopeptide repeat
MC28_RS21765	COG0110	maltose O-acetyltransferase activity
MC28_RS21785	COG1950	PFAM Membrane protein of
MC28_RS21795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MC28_RS21800	COG0556	nucleotide-excision repair
MC28_RS21810	COG0789	Transcriptional regulator
MC28_RS21830	COG0583	DNA-binding transcription factor activity
MC28_RS21840	COG0655	NAD(P)H dehydrogenase (quinone) activity
MC28_RS21845	COG0488	(ABC) transporter
MC28_RS21855	COG1132	(ABC) transporter
MC28_RS21860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_RS21865	COG0793	Belongs to the peptidase S41A family
MC28_RS21865	COG3409	Peptidoglycan-binding domain 1 protein
MC28_RS21870	COG2177	Part of the ABC transporter FtsEX involved in
MC28_RS21875	COG2884	Cell division ATP-binding protein ftsE
MC28_RS21885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MC28_RS21895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MC28_RS21900	COG1278	Cold shock
MC28_RS21905	COG1040	competence protein
MC28_RS21910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MC28_RS21915	COG0791	NLP P60 protein
MC28_RS21915	COG1388	LysM domain
MC28_RS21920	COG1733	regulation of RNA biosynthetic process
MC28_RS21925	COG1307	EDD domain protein, DegV family
MC28_RS21930	COG1739	Uncharacterized protein family UPF0029
MC28_RS21935	COG1316	TRANSCRIPTIONal
MC28_RS21940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MC28_RS21945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MC28_RS21950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MC28_RS21960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MC28_RS21960	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MC28_RS21980	COG1486	melibiose metabolic process
MC28_RS21985	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_RS21990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_RS22005	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MC28_RS22015	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_RS22025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_RS22030	COG1301	dicarboxylic acid transport
MC28_RS22045	COG1511	domain protein
MC28_RS22050	COG0583	DNA-binding transcription factor activity
MC28_RS22055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MC28_RS22065	COG1271	oxidase subunit
MC28_RS22070	COG1294	oxidase, subunit
MC28_RS22075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_RS22085	COG1620	l-lactate permease
MC28_RS22095	COG2389	metal-binding protein
MC28_RS22105	COG1368	sulfuric ester hydrolase activity
MC28_RS22115	COG1388	LysM domain
MC28_RS22115	COG0791	NLP P60 protein
MC28_RS22120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS22130	COG1215	transferase activity, transferring glycosyl groups
MC28_RS22140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC28_RS22145	COG1388	LysM domain
MC28_RS22145	COG3584	3D domain protein
MC28_RS22155	COG4715	Zinc finger, swim domain protein
MC28_RS22160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_RS22200	COG0577	efflux transmembrane transporter activity
MC28_RS22205	COG1136	(ABC) transporter
MC28_RS22230	COG2205	protein histidine kinase activity
MC28_RS22235	COG0745	RESPONSE REGULATOR receiver
MC28_RS22240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_RS22245	COG4750	Nucleotidyl transferase
MC28_RS22250	COG0697	spore germination
MC28_RS22260	COG3475	LICD family
MC28_RS22270	COG1316	TRANSCRIPTIONal
MC28_RS22280	COG0438	transferase activity, transferring glycosyl groups
MC28_RS22285	COG0463	Glycosyl transferase, family 2
MC28_RS22285	COG1216	Glycosyl transferase, family 2
MC28_RS22315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC28_RS22320	COG4464	protein tyrosine phosphatase activity
MC28_RS22325	COG0489	protein tyrosine kinase activity
MC28_RS22330	COG3944	biosynthesis protein
MC28_RS22335	COG0489	protein tyrosine kinase activity
MC28_RS22350	COG1609	Transcriptional regulator
MC28_RS22360	COG0739	heme binding
MC28_RS22375	COG3279	Response regulator of the LytR AlgR family
MC28_RS22380	COG2385	sporulation resulting in formation of a cellular spore
MC28_RS22395	COG4836	Membrane
MC28_RS22400	COG1007	ATP synthesis coupled electron transport
MC28_RS22405	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC28_RS22410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC28_RS22420	COG0839	Belongs to the complex I subunit 6 family
MC28_RS22440	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC28_RS22485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MC28_RS22505	COG0356	it plays a direct role in the translocation of protons across the membrane
MC28_RS22540	COG0698	ribose 5-phosphate isomerase
MC28_RS22550	COG2190	(PTS) system
MC28_RS22555	COG2259	Doxx family
MC28_RS22560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MC28_RS22575	COG0009	L-threonylcarbamoyladenylate synthase
MC28_RS22595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MC28_RS22610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MC28_RS22615	COG1494	fructose-1,6-bisphosphatase
MC28_RS22635	COG4821	SIS domain
MC28_RS22640	COG0504	CTP synthase activity
MC28_RS22655	COG1960	acyl-CoA dehydrogenase activity
MC28_RS22660	COG1960	acyl-CoA dehydrogenase activity
MC28_RS22665	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC28_RS22670	COG0183	Belongs to the thiolase family
MC28_RS22675	COG2181	nitrate reductase activity
MC28_RS22675	COG0247	lactate metabolic process
MC28_RS22680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_RS22690	COG5001	Diguanylate cyclase
MC28_RS22690	COG3300	MHYT domain
MC28_RS22705	COG3227	Zinc metalloprotease (Elastase)
MC28_RS22710	COG2197	response regulator
MC28_RS22715	COG4585	Histidine kinase
MC28_RS22720	COG0842	Transport permease protein
MC28_RS22725	COG1131	(ABC) transporter
MC28_RS22730	COG0024	Methionine aminopeptidase
MC28_RS22740	COG2234	aminopeptidase activity
MC28_RS22765	COG4506	Protein conserved in bacteria
MC28_RS22770	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_RS22790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MC28_RS22795	COG2814	Major facilitator Superfamily
MC28_RS22800	COG0789	Transcriptional regulator
MC28_RS22805	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_RS22810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_RS22820	COG1994	Peptidase M50
MC28_RS22830	COG1078	dGTPase activity
MC28_RS22835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS22840	COG1120	ATPase activity
MC28_RS22845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS22850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS22855	COG4844	belongs to the
MC28_RS22870	COG0280	phosphate acetyltransferase
MC28_RS22885	COG3773	Cell wall hydrolase
MC28_RS22895	COG2363	Small membrane protein
MC28_RS22905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC28_RS22910	COG2233	PERMEase
MC28_RS22915	COG0561	phosphatase activity
MC28_RS22920	COG2814	Major facilitator Superfamily
MC28_RS22930	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MC28_RS22935	COG1131	(ABC) transporter
MC28_RS22940	COG2755	lipolytic protein G-D-S-L family
MC28_RS22945	COG1609	Transcriptional regulator
MC28_RS22955	COG0460	homoserine dehydrogenase
MC28_RS22965	COG2873	o-acetylhomoserine
MC28_RS22975	COG1011	Hydrolase
MC28_RS22980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_RS22990	COG2197	response regulator
MC28_RS22995	COG2203	Gaf domain
MC28_RS22995	COG4585	Histidine kinase
MC28_RS23000	COG0351	phosphomethylpyrimidine kinase
MC28_RS23005	COG3706	GGDEF domain
MC28_RS23010	COG2879	small protein
MC28_RS23015	COG1966	Carbon starvation protein
MC28_RS23020	COG3279	Response regulator of the LytR AlgR family
MC28_RS23025	COG0477	Major facilitator Superfamily
MC28_RS23035	COG0438	transferase activity, transferring glycosyl groups
MC28_RS23050	COG0840	transmembrane signaling receptor activity
MC28_RS23060	COG1607	acyl-coa hydrolase
MC28_RS23070	COG1215	transferase activity, transferring glycosyl groups
MC28_RS23080	COG1309	transcriptional regulator
MC28_RS23085	COG0488	(ABC) transporter
MC28_RS23100	COG0463	Glycosyl transferase, family 2
MC28_RS23105	COG1309	transcriptional regulator
MC28_RS23110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC28_RS23115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_RS23115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_RS23120	COG0628	permease
MC28_RS23140	COG3275	phosphorelay sensor kinase activity
MC28_RS23145	COG2814	Major facilitator Superfamily
MC28_RS23150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC28_RS23155	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MC28_RS23160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_RS23180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_RS23185	COG1272	protein, Hemolysin III
MC28_RS23210	COG1164	Oligoendopeptidase f
MC28_RS23230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_RS23235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MC28_RS23240	COG4853	Protein conserved in bacteria
MC28_RS23250	COG5002	protein histidine kinase activity
MC28_RS23255	COG0745	RESPONSE REGULATOR receiver
MC28_RS23285	COG0305	Participates in initiation and elongation during chromosome replication
MC28_RS23295	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MC28_RS23300	COG4241	membrane
MC28_RS23310	COG0629	single-stranded DNA binding
MC28_RS23320	COG0012	GTP binding
MC28_RS23325	COG4481	Protein conserved in bacteria
MC28_RS23330	COG0668	transmembrane transport
MC28_RS23340	COG1475	DNA binding
MC28_RS23345	COG1192	Involved in chromosome partitioning
MC28_RS23370	COG1847	R3H domain protein
MC28_RS23375	COG0706	membrane insertase activity
MC28_RS23385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MC28_RS23395	COG0592	DNA-directed DNA polymerase activity
MC28_RS23400	COG2501	S4 domain
MC28_RS23410	COG0187	DNA topoisomerase II activity
MC28_RS23415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MC28_RS23440	COG0516	GMP reductase activity
MC28_RS23440	COG0517	IMP dehydrogenase activity
MC28_RS23445	COG1686	Belongs to the peptidase S11 family
MC28_RS23475	COG1428	Deoxynucleoside kinase
MC28_RS23480	COG1428	Deoxynucleoside kinase
MC28_RS23485	COG1335	isochorismatase
MC28_RS23490	COG0590	tRNA wobble adenosine to inosine editing
MC28_RS23495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MC28_RS23540	COG1982	Orn Lys Arg decarboxylase major
MC28_RS23550	COG0470	DNA polymerase III
MC28_RS23555	COG1774	PSP1 C-terminal conserved region
MC28_RS23565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MC28_RS23575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MC28_RS23580	COG2002	toxin-antitoxin pair type II binding
MC28_RS23590	COG0084	hydrolase, TatD family'
MC28_RS23600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MC28_RS23610	COG4466	Protein conserved in bacteria
MC28_RS23625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MC28_RS23630	COG0251	oxidation-reduction process
MC28_RS23635	COG2088	sporulation resulting in formation of a cellular spore
MC28_RS23660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MC28_RS23665	COG2002	toxin-antitoxin pair type II binding
MC28_RS23670	COG2244	polysaccharide biosynthetic process
MC28_RS23675	COG3956	TIGRFAM MazG family protein
MC28_RS23680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MC28_RS23700	COG1098	S1 RNA binding domain
MC28_RS23715	COG2208	phosphoserine phosphatase activity
MC28_RS23725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MC28_RS23730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MC28_RS23745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_RS23750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MC28_RS23755	COG0512	Glutamine amidotransferase of anthranilate synthase
MC28_RS23760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_RS23765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MC28_RS23770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MC28_RS23775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MC28_RS23780	COG1396	sequence-specific DNA binding
MC28_RS23785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC28_RS23815	COG3880	PFAM UvrB UvrC protein
MC28_RS23825	COG0542	response to heat
MC28_RS23830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MC28_RS23840	COG4956	integral membrane protein (PIN domain superfamily)
MC28_RS23860	COG1045	serine acetyltransferase
MC28_RS23875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC28_RS23880	COG3688	RNA-binding protein containing a PIN domain
MC28_RS23890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MC28_RS23895	COG0250	Participates in transcription elongation, termination and antitermination
MC28_RS23900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MC28_RS23905	COG0081	regulation of translation
MC28_RS23915	COG0222	ribosome binding
MC28_RS23920	COG2813	Specifically methylates the guanine in position
MC28_RS23935	COG1358	cellular component organization or biogenesis
MC28_RS23940	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MC28_RS23960	COG0051	transcription antitermination factor activity, RNA binding
MC28_RS23965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MC28_RS24005	COG0255	Belongs to the universal ribosomal protein uL29 family
MC28_RS24055	COG1841	ribosomal large subunit assembly
MC28_RS24065	COG0201	protein transport
MC28_RS24075	COG0024	Methionine aminopeptidase
MC28_RS24085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC28_RS24120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MC28_RS24145	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_RS24150	COG0489	protein tyrosine kinase activity
MC28_RS24160	COG2194	sulfuric ester hydrolase activity
MC28_RS24165	COG0726	polysaccharide deacetylase
MC28_RS24245	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MC28_RS24250	COG4856	YbbR-like protein
MC28_RS24255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC28_RS24290	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_RS24300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MC28_RS24305	COG1464	Belongs to the NlpA lipoprotein family
MC28_RS24320	COG0277	FAD linked oxidase domain protein
MC28_RS24325	COG2271	Major facilitator Superfamily
MC28_RS24335	COG2814	Major facilitator Superfamily
MC28_RS24350	COG0601	transmembrane transport
MC28_RS24355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_RS24360	COG0444	Belongs to the ABC transporter superfamily
MC28_RS24365	COG4608	Belongs to the ABC transporter superfamily
MC28_RS24370	COG4166	transmembrane transport
MC28_RS24380	COG2207	Transcriptional regulator
MC28_RS24390	COG4166	transmembrane transport
MC28_RS24395	COG4166	transmembrane transport
MC28_RS24400	COG0656	L-ascorbic acid biosynthetic process
MC28_RS24420	COG4149	molybdate abc transporter
MC28_RS24425	COG0725	ABC transporter, periplasmic molybdate-binding protein
MC28_RS24430	COG1910	domain protein
MC28_RS24440	COG0697	spore germination
MC28_RS24450	COG1609	Transcriptional regulator
MC28_RS24460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_RS24480	COG5298	Protein conserved in bacteria
MC28_RS24500	COG0488	(ABC) transporter
MC28_RS24510	COG0747	negative chemotaxis
MC28_RS24515	COG0601	transmembrane transport
MC28_RS24520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_RS24525	COG0444	Belongs to the ABC transporter superfamily
MC28_RS24530	COG4608	Belongs to the ABC transporter superfamily
MC28_RS24535	COG0561	phosphatase activity
MC28_RS24570	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MC28_RS24575	COG0179	Fumarylacetoacetate (FAA) hydrolase
MC28_RS24585	COG0531	amino acid
MC28_RS24590	COG2814	Major facilitator Superfamily
MC28_RS24600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MC28_RS24610	COG4294	response to UV
MC28_RS24615	COG0705	Rhomboid family
MC28_RS24625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MC28_RS24630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC28_RS24635	COG0864	Transcriptional regulator
MC28_RS24640	COG2337	Toxic component of a toxin-antitoxin (TA) module
MC28_RS24645	COG2183	response to ionizing radiation
MC28_RS24740	COG0802	atpase or kinase
MC28_RS24745	COG1214	PFAM Peptidase M22, glycoprotease
MC28_RS24750	COG0456	acetyltransferase
MC28_RS24760	COG0488	(ABC) transporter
MC28_RS24775	COG1266	CAAX protease self-immunity
MC28_RS24785	COG0459	protein refolding
MC28_RS24830	COG1674	ftsk spoiiie
MC28_RS24840	COG2946	Replication initiation factor
MC28_RS24855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MC28_RS24865	COG2252	PERMEase
MC28_RS24875	COG5002	protein histidine kinase activity
MC28_RS24900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MC28_RS24930	COG2226	methyltransferase
MC28_RS24950	COG1215	transferase activity, transferring glycosyl groups
MC28_RS24970	COG0697	spore germination
MC28_RS25020	COG2205	protein histidine kinase activity
MC28_RS25025	COG0745	RESPONSE REGULATOR receiver
MC28_RS25055	COG2226	methyltransferase
MC28_RS25065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_RS25075	COG1215	transferase activity, transferring glycosyl groups
MC28_RS25095	COG0697	spore germination
MC28_RS25125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MC28_RS25130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MC28_RS25135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC28_RS25145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MC28_RS25160	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MC28_RS25170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MC28_RS25175	COG0138	bifunctional purine biosynthesis protein purh
MC28_RS25180	COG0151	Belongs to the GarS family
MC28_RS25205	COG0210	DNA helicase
MC28_RS25215	COG4851	CamS sex pheromone cAM373 precursor
MC28_RS25230	COG1335	isochorismatase
MC28_RS25240	COG2011	ABC-type metal ion transport system permease component
MC28_RS25245	COG1464	Belongs to the NlpA lipoprotein family
MC28_RS25255	COG0003	Pfam Anion-transporting ATPase
MC28_RS25260	COG1846	Transcriptional regulator
MC28_RS25265	COG4682	membrane
MC28_RS25285	COG1597	lipid kinase activity
MC28_RS25290	COG0546	phosphoglycolate phosphatase activity
MC28_RS25295	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MC28_RS25305	COG1012	belongs to the aldehyde dehydrogenase family
MC28_RS25310	COG2076	Multidrug Resistance protein
MC28_RS25320	COG2309	aminopeptidase activity
MC28_RS25335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS25345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC28_RS25350	COG5002	protein histidine kinase activity
MC28_RS25355	COG4807	Protein conserved in bacteria
MC28_RS25380	COG1757	Na H antiporter
MC28_RS25385	COG1473	amidohydrolase
MC28_RS25400	COG0450	alkyl hydroperoxide reductase
MC28_RS25420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS25425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS25430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS25435	COG0492	ferredoxin-NADP+ reductase activity
MC28_RS25445	COG0166	Belongs to the GPI family
MC28_RS25470	COG5002	protein histidine kinase activity
MC28_RS25490	COG3541	Predicted nucleotidyltransferase
MC28_RS25495	COG2814	Major facilitator Superfamily
MC28_RS25500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_RS25500	COG0723	plastoquinol--plastocyanin reductase activity
MC28_RS25510	COG0765	amino acid transport
MC28_RS25515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_RS25525	COG0840	transmembrane signaling receptor activity
MC28_RS25550	COG0549	Belongs to the carbamate kinase family
MC28_RS25565	COG0277	FAD linked oxidase domain protein
MC28_RS25570	COG0366	Alpha amylase catalytic
MC28_RS25575	COG2190	(PTS) system
MC28_RS25575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS25575	COG1263	PTS System
MC28_RS25605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC28_RS25610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC28_RS25630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_RS25640	COG1116	anion transmembrane transporter activity
MC28_RS25685	COG2270	Major facilitator Superfamily
MC28_RS25710	COG4193	domain, Protein
MC28_RS25720	COG2310	stress, protein
MC28_RS25725	COG2310	stress, protein
MC28_RS25730	COG2310	stress, protein
MC28_RS25735	COG0861	Integral membrane protein TerC family
MC28_RS25745	COG3853	Toxic anion resistance protein (TelA)
MC28_RS25760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MC28_RS25770	COG1295	ribonuclease BN
MC28_RS25775	COG2217	Heavy metal translocating P-type atpase
MC28_RS25780	COG0697	spore germination
MC28_RS25800	COG0586	Pfam SNARE associated Golgi protein
MC28_RS25815	COG3871	stress protein (general stress protein 26)
MC28_RS25820	COG0387	Pfam Sodium calcium exchanger
MC28_RS25830	COG0535	radical SAM domain protein
MC28_RS25850	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MC28_RS25855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC28_RS25860	COG0582	viral genome integration into host DNA
MC28_RS25920	COG1484	DNA-dependent DNA replication
MC28_RS26015	COG0582	viral genome integration into host DNA
MC28_RS26070	COG0740	serine-type endopeptidase activity
MC28_RS26135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MC28_RS26180	COG3829	transcription factor binding
MC28_RS26190	COG0833	amino acid
MC28_RS26195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_RS26220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS26220	COG1263	PTS System
MC28_RS26225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_RS26245	COG0463	Glycosyl transferase, family 2
MC28_RS26255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_RS26255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC28_RS26260	COG0463	Glycosyl transferase, family 2
MC28_RS26265	COG1882	Formate acetyltransferase
MC28_RS26270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MC28_RS26290	COG1228	amidohydrolase
MC28_RS26295	COG1090	epimerase
MC28_RS26325	COG1988	membrane-bound metal-dependent
MC28_RS26330	COG1194	a g-specific adenine glycosylase
MC28_RS26350	COG3557	Belongs to the UPF0374 family
MC28_RS26355	COG1132	(ABC) transporter
MC28_RS26360	COG4129	membrane
MC28_RS26365	COG0069	glutamate synthase activity
MC28_RS26365	COG0070	glutamate synthase
MC28_RS26365	COG0067	glutamate synthase
MC28_RS26370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MC28_RS26375	COG4555	ABC transporter
MC28_RS26395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MC28_RS26400	COG0735	belongs to the Fur family
MC28_RS26520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MC28_RS26545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MC28_RS26550	COG1716	ATPase activity
MC28_RS26550	COG5001	Diguanylate cyclase
MC28_RS26555	COG2766	serine protein kinase
MC28_RS26560	COG2718	Belongs to the UPF0229 family
MC28_RS26575	COG1585	Membrane protein implicated in regulation of membrane protease activity
MC28_RS26580	COG2268	Band 7 protein
MC28_RS26590	COG3290	protein histidine kinase activity
MC28_RS26595	COG4565	transcriptional regulatory protein
MC28_RS26600	COG2851	Citrate transporter
MC28_RS26625	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MC28_RS26630	COG3842	ATPase activity
MC28_RS26635	COG1175	transmembrane transport
MC28_RS26640	COG0395	ABC-type sugar transport system, permease component
MC28_RS26650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MC28_RS26655	COG0745	RESPONSE REGULATOR receiver
MC28_RS26660	COG5002	protein histidine kinase activity
MC28_RS26670	COG4990	cell redox homeostasis
MC28_RS26680	COG3290	protein histidine kinase activity
MC28_RS26685	COG4565	transcriptional regulatory protein
MC28_RS26690	COG3493	citrate carrier protein
MC28_RS26695	COG0281	malic enzyme
MC28_RS26705	COG0697	spore germination
MC28_RS26710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_RS26720	COG5002	protein histidine kinase activity
MC28_RS26725	COG0745	RESPONSE REGULATOR receiver
MC28_RS26735	COG0454	-acetyltransferase
MC28_RS26735	COG0456	acetyltransferase
MC28_RS26740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC28_RS26745	COG3383	formate dehydrogenase (NAD+) activity
MC28_RS26750	COG2427	Protein of unknown function (DUF1641)
MC28_RS26765	COG0531	amino acid
MC28_RS26775	COG0640	Transcriptional regulator
MC28_RS26780	COG2217	Heavy metal translocating P-type atpase
MC28_RS26785	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MC28_RS26795	COG3227	Zinc metalloprotease (Elastase)
MC28_RS26815	COG2720	vancomycin resistance protein
MC28_RS26820	COG1316	TRANSCRIPTIONal
MC28_RS26825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_RS26830	COG0346	lactoylglutathione lyase activity
MC28_RS26835	COG1253	flavin adenine dinucleotide binding
MC28_RS26840	COG1027	Aspartate ammonia-lyase
MC28_RS26845	COG1620	l-lactate permease
MC28_RS26860	COG3104	oligopeptide transport
MC28_RS26865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_RS26870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS26875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_RS26885	COG2226	methyltransferase
MC28_RS26895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_RS26905	COG4548	von Willebrand factor, type A
MC28_RS26910	COG0714	Associated with various cellular activities
MC28_RS26930	COG0531	amino acid
MC28_RS26935	COG2188	Transcriptional regulator
MC28_RS26940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS26940	COG1263	PTS System
MC28_RS26945	COG0366	Alpha amylase catalytic
MC28_RS26960	COG0697	spore germination
MC28_RS26965	COG4585	Histidine kinase
MC28_RS26970	COG2197	response regulator
MC28_RS26975	COG1404	Belongs to the peptidase S8 family
MC28_RS26985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC28_RS26990	COG1115	amino acid carrier protein
MC28_RS26995	COG1126	abc transporter atp-binding protein
MC28_RS27000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_RS27005	COG0765	amino acid transport
MC28_RS27010	COG0765	amino acid transport
MC28_RS27015	COG0833	amino acid
MC28_RS27040	COG2378	regulation of single-species biofilm formation
MC28_RS27045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MC28_RS27050	COG5002	protein histidine kinase activity
MC28_RS27065	COG0659	secondary active sulfate transmembrane transporter activity
MC28_RS27080	COG2271	Major facilitator Superfamily
MC28_RS27085	COG1846	Transcriptional regulator
MC28_RS27090	COG0477	Major facilitator Superfamily
MC28_RS27095	COG1609	Transcriptional regulator
MC28_RS27100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC28_RS27115	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_RS27120	COG1879	ABC-type sugar transport system periplasmic component
MC28_RS27150	COG1063	alcohol dehydrogenase
MC28_RS27200	COG0840	transmembrane signaling receptor activity
MC28_RS27205	COG1388	LysM domain
MC28_RS27205	COG3584	3D domain protein
MC28_RS27210	COG1476	TRANSCRIPTIONal
MC28_RS27230	COG3104	oligopeptide transport
MC28_RS27235	COG1114	Component of the transport system for branched-chain amino acids
MC28_RS27250	COG1113	amino acid transport
MC28_RS27255	COG2252	PERMEase
MC28_RS27275	COG0475	glutathione-regulated potassium exporter activity
MC28_RS27275	COG0569	domain protein
MC28_RS27290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MC28_RS27295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC28_RS27300	COG0833	amino acid
MC28_RS27305	COG4990	cell redox homeostasis
MC28_RS27320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_RS27325	COG0697	spore germination
MC28_RS27330	COG0531	amino acid
MC28_RS27340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_RS27345	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_RS27350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_RS27350	COG1918	ferrous iron import across plasma membrane
MC28_RS27355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MC28_RS27360	COG0573	inorganic phosphate transmembrane transporter activity
MC28_RS27365	COG0581	inorganic phosphate transmembrane transporter activity
MC28_RS27370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC28_RS27505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MC28_RS27595	COG1129	ABC transporter
MC28_RS27690	COG0778	Nitroreductase
MC28_RS27700	COG2719	SpoVR family
MC28_RS27765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS27795	COG0730	response to heat
MC28_RS27840	COG1116	anion transmembrane transporter activity
MC28_RS28015	COG2719	SpoVR family
MC28_RS28020	COG2719	SpoVR family
MC28_RS28045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_RS28055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS28055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS28085	COG0730	response to heat
MC28_RS28095	COG1316	TRANSCRIPTIONal
MC28_RS28215	COG1737	Transcriptional regulator
MC28_RS28485	COG2719	SpoVR family
MC28_RS28530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS28530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS28535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_RS28535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_RS28790	COG1263	PTS System
MC28_RS28790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS28835	COG1309	transcriptional regulator
MC28_RS28955	COG0028	Belongs to the TPP enzyme family
MC28_RS28980	COG0561	phosphatase activity
MC28_RS29175	COG3290	protein histidine kinase activity
MC28_RS29200	COG0513	Belongs to the DEAD box helicase family
MC28_RS29445	COG2719	SpoVR family
MC28_RS29470	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC28_RS29720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MC28_RS30185	COG1129	ABC transporter
MC28_RS30210	COG2252	PERMEase
MC28_RS30395	COG0475	glutathione-regulated potassium exporter activity
MC28_RS30420	COG1263	PTS System
MC28_RS30420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_RS30520	COG1132	(ABC) transporter
MC28_RS30615	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_RS30625	COG0659	secondary active sulfate transmembrane transporter activity
MC28_RS30745	COG3290	protein histidine kinase activity
MC28_RS30875	COG1183	phosphatidylcholine synthase activity
MC28_RS31550	COG0697	spore germination
MC28_RS31710	COG3546	catalase activity
MC28_RS32115	COG0477	Major facilitator Superfamily
MC28_RS32255	COG2814	Major facilitator Superfamily
MC28_RS32710	COG0095	Lipoate-protein ligase
MC28_RS32810	COG0697	spore germination
MC28_RS33145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_RS33300	COG3409	Peptidoglycan-binding domain 1 protein
MC28_RS33300	COG5632	N-Acetylmuramoyl-L-alanine amidase
MC28_RS33305	COG2376	Dihydroxyacetone kinase
MC28_RS33325	COG4886	Leucine-rich repeat (LRR) protein
MC28_RS33325	COG4932	domain protein