locus-tag class description HIS92_RS00050 ENOG4108M1A Chitin-binding protein HIS92_RS00070 ENOG4105BZG amino acid carrier protein HIS92_RS00075 ENOG4105C26 Dehydrogenase HIS92_RS00080 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HIS92_RS00090 ENOG4105CTU Proline racemase HIS92_RS00095 ENOG41080HI glycine oxidase HIS92_RS00105 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HIS92_RS00140 ENOG4107T5V SNARE associated Golgi HIS92_RS00150 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HIS92_RS00165 ENOG4105DTQ mandelate racemase muconate lactonizing HIS92_RS00180 ENOG4107SET aldo keto reductase HIS92_RS00215 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HIS92_RS00220 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HIS92_RS00225 ENOG4105BZU Histidine kinase HIS92_RS00230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS00255 ENOG4105DPN Oligoendopeptidase f HIS92_RS00260 ENOG4105EPR degv family HIS92_RS00320 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HIS92_RS00325 ENOG4106K7D Major facilitator family transporter HIS92_RS00350 ENOG4107BMA Transglycosylase associated protein HIS92_RS00365 ENOG41089UC methyltransferase, type 11 HIS92_RS00400 ENOG4105CHM Aminotransferase HIS92_RS00450 ENOG4105C02 permease HIS92_RS00465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HIS92_RS00470 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HIS92_RS00475 ENOG4105D7T ABC transporter HIS92_RS00500 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HIS92_RS00535 ENOG4107VC0 DNA alkylation repair enzyme HIS92_RS00540 ENOG4105C6T cysteine synthase HIS92_RS00545 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HIS92_RS00580 ENOG4108ZCF integral membrane protein HIS92_RS00585 ENOG4105E0M Sulfatase HIS92_RS00590 ENOG4105C5H ABC transporter HIS92_RS00595 ENOG4105EYF MMPL domain protein HIS92_RS00600 ENOG41082JN Transcriptional regulator HIS92_RS00625 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HIS92_RS00630 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HIS92_RS00650 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HIS92_RS00665 ENOG41069ER domain protein HIS92_RS00695 ENOG4105D4B ABC, transporter HIS92_RS00705 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HIS92_RS00715 ENOG4105DKT Transcriptional regulator HIS92_RS00720 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HIS92_RS00730 ENOG41061GT Aldolase HIS92_RS00745 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HIS92_RS00775 ENOG4105II7 pyrroline-5-carboxylate reductase HIS92_RS00785 ENOG4107258 Transcriptional regulator HIS92_RS00800 ENOG4105E0Y RtcB Protein HIS92_RS00810 ENOG4105ECK Fatty Acid Desaturase HIS92_RS00820 ENOG4107RBI VanW family HIS92_RS00825 ENOG4105G6Z alkaline phosphatase HIS92_RS00835 ENOG4105VMP Transcriptional regulator HIS92_RS00855 ENOG41068WN HIS92_RS00880 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HIS92_RS00900 ENOG4105CSH Transporter HIS92_RS00905 ENOG4105C8Y Acetylornithine aminotransferase HIS92_RS00940 ENOG41090AA HIS92_RS00970 ENOG4108TVJ Nitroreductase HIS92_RS00975 ENOG4105FS7 Transcriptional regulator HIS92_RS00990 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HIS92_RS00995 ENOG4105WEC Molybdate metabolism regulator HIS92_RS01000 ENOG4105CMR udp-glucose 4-epimerase HIS92_RS01005 ENOG4105C19 ABC transporter HIS92_RS01030 ENOG4108XET gCN5-related N-acetyltransferase HIS92_RS01040 ENOG4105E09 nadh pyrophosphatase HIS92_RS01045 ENOG4108PCN EamA-like transporter family HIS92_RS01095 ENOG410635A Membrane HIS92_RS01105 ENOG4108IQI permease HIS92_RS01150 ENOG4108VJ1 Transcriptional regulator (CarD family HIS92_RS01160 ENOG4105BZU Histidine kinase HIS92_RS01185 ENOG4107RF6 penicillin-binding protein HIS92_RS01190 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HIS92_RS01220 ENOG4105P4J Allophanate hydrolase, subunit 1 HIS92_RS01225 ENOG4107258 Transcriptional regulator HIS92_RS01235 ENOG4106N3A copper homeostasis protein cutc HIS92_RS01240 ENOG4108ZHR arsR family transcriptional regulator HIS92_RS01250 ENOG4105FDT acyl-CoA dehydrogenase HIS92_RS01265 ENOG4105DWD nucleoside recognition domain protein HIS92_RS01305 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HIS92_RS01330 ENOG4105E2A Dehydrogenase HIS92_RS01340 ENOG4108IJ0 Aspartate ammonia-lyase HIS92_RS01350 ENOG4108IMY Transcriptional regulator HIS92_RS01370 ENOG4108B31 Spore germination protein HIS92_RS01380 ENOG4105BZU Histidine kinase HIS92_RS01405 ENOG41075H3 AraC family transcriptional regulator HIS92_RS01415 ENOG4105YWU small acid-soluble spore protein HIS92_RS01420 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HIS92_RS01425 ENOG4105CUB amino acid HIS92_RS01430 ENOG4105II7 pyrroline-5-carboxylate reductase HIS92_RS01440 ENOG4108Q8B Spore germination protein HIS92_RS01475 ENOG4106A3M Cytochrome p-450 HIS92_RS01490 ENOG4105CGH 5'-nucleotidase HIS92_RS01500 ENOG4105CHJ isochorismatase hydrolase HIS92_RS01525 ENOG41090MY MarR family Transcriptional regulator HIS92_RS01550 ENOG4105F6J Alpha beta hydrolase fold HIS92_RS01565 ENOG4108606 TspO/MBR family HIS92_RS01570 ENOG4105CVP deoxyribo-dipyrimidine photolyase HIS92_RS01585 ENOG4108TWJ NADH dehydrogenase subunit 5 HIS92_RS01590 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HIS92_RS01605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HIS92_RS01610 ENOG4105DSE periplasmic solute binding protein HIS92_RS01615 ENOG4105CC5 ABC transporter HIS92_RS01620 ENOG4105DIK (ABC) transporter HIS92_RS01640 ENOG4105D6J arsenicaL-resistance protein HIS92_RS01645 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HIS92_RS01650 ENOG41085FC arsR family transcriptional regulator HIS92_RS01660 ENOG4105EGI Transcriptional regulator HIS92_RS01700 ENOG4105VZ8 Transcriptional regulator HIS92_RS01710 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HIS92_RS01720 ENOG4107P5I polyketide synthase HIS92_RS01725 ENOG4108IG5 Transcriptional regulator HIS92_RS01730 ENOG4105CHR reductase HIS92_RS01735 ENOG4108YXU transcriptional regulator AsnC family HIS92_RS01775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS01820 ENOG4105DNP FAD linked oxidase domain protein HIS92_RS01830 ENOG4105C19 ABC transporter HIS92_RS01860 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HIS92_RS01865 ENOG4105C0R drug resistance transporter emrb qaca subfamily HIS92_RS01875 ENOG4105K6H D-cysteine desulfhydrase HIS92_RS01895 ENOG4105JQZ Methyltransferase HIS92_RS01915 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HIS92_RS01935 ENOG4105BZU Histidine kinase HIS92_RS01950 ENOG4108U05 Transcriptional regulator HIS92_RS01955 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HIS92_RS01965 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HIS92_RS01990 ENOG4108JQ1 Dehydrogenase HIS92_RS01995 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HIS92_RS02010 ENOG41082W1 Cupin 2, conserved barrel domain protein HIS92_RS02015 ENOG410874W AraC family transcriptional regulator HIS92_RS02030 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HIS92_RS02040 ENOG4108IG5 Transcriptional regulator HIS92_RS02145 ENOG4107EV6 Inherit from COG: YD repeat protein HIS92_RS02170 ENOG4108VXD carboxy-peptidase HIS92_RS02175 ENOG4105PNM synthesis protein HIS92_RS02185 ENOG4108ISG Major Facilitator HIS92_RS02200 ENOG4107MII Sugar-specific transcriptional regulator TrmB HIS92_RS02205 ENOG4105CZM Major Facilitator HIS92_RS02215 ENOG4105CRW Short chain fatty acid transporter HIS92_RS02230 ENOG4105DYS nad(p)h dehydrogenase (quinone) HIS92_RS02290 ENOG4108K8S endonuclease I HIS92_RS02300 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HIS92_RS02305 ENOG4108Z66 YbaK ebsC protein HIS92_RS02325 ENOG4105KVH Transcriptional regulator HIS92_RS02330 ENOG4108RCM Nitroreductase HIS92_RS02360 ENOG4108PSK reductase HIS92_RS02425 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HIS92_RS02430 ENOG4105DKQ ROK family HIS92_RS02435 ENOG4106UW1 Major Facilitator superfamily HIS92_RS02440 ENOG4108UW5 maltose o-acetyltransferase HIS92_RS02450 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HIS92_RS02500 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HIS92_RS02510 ENOG4105EV4 Multidrug resistance protein mdtH HIS92_RS02540 ENOG4105C37 (CBS) domain HIS92_RS02565 ENOG4105DDN Pentapeptide repeat-containing protein HIS92_RS02570 ENOG4105XDF Protein of unknown function (DUF1272) HIS92_RS02575 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HIS92_RS02580 ENOG4105CMG Carbohydrate kinase HIS92_RS02585 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HIS92_RS02595 ENOG4105CV1 Transketolase (EC 2.2.1.1) HIS92_RS02600 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HIS92_RS02620 ENOG4105C44 Serine transporter HIS92_RS02650 ENOG4105KVH Transcriptional regulator HIS92_RS02655 ENOG4108TZY GntR Family Transcriptional Regulator HIS92_RS02660 ENOG4105D9R oxidoreductase HIS92_RS02705 ENOG4105JAB phenazine biosynthesis protein, phzf family HIS92_RS02720 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HIS92_RS02725 ENOG4105KVH Transcriptional regulator HIS92_RS02730 ENOG4107SCK Monooxygenase HIS92_RS02800 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HIS92_RS02835 ENOG4105H3G oxidoreductase HIS92_RS02870 ENOG4105CIS alcohol dehydrogenase HIS92_RS02905 ENOG4108TN2 lmbE family HIS92_RS02915 ENOG4107R3E Citrate transporter HIS92_RS02925 ENOG4105WCN acetyltransferase HIS92_RS02930 ENOG4105NX3 Membrane HIS92_RS02950 ENOG4107CUJ Protein of unknown function (DUF2690) HIS92_RS02960 ENOG4107V2S Transcriptional regulator HIS92_RS02980 ENOG4105C98 muts2 protein HIS92_RS02990 ENOG4105E5K Alpha-amylase HIS92_RS02995 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HIS92_RS03000 ENOG4105DPN Oligoendopeptidase f HIS92_RS03035 ENOG4108A04 Beta-lactamase HIS92_RS03060 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HIS92_RS03070 ENOG41082BM Transcriptional regulator, arsr family HIS92_RS03075 ENOG4105CIS alcohol dehydrogenase HIS92_RS03095 ENOG4105C09 Bile acid HIS92_RS03100 ENOG4105CQB FAD linked oxidase domain protein HIS92_RS03120 ENOG4105CEP NADH dehydrogenase HIS92_RS03145 ENOG4105D2T synthase HIS92_RS03160 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HIS92_RS03165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HIS92_RS03170 ENOG4105C1B dTDP-glucose 4-6-dehydratase HIS92_RS03175 ENOG4105C5E polysaccharide biosynthesis protein HIS92_RS03200 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HIS92_RS03205 ENOG4108M1A Chitin-binding protein HIS92_RS03215 ENOG4105E1K spore germination protein HIS92_RS03235 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HIS92_RS03250 ENOG4105FAW cDP-glucose 4,6-dehydratase HIS92_RS03300 ENOG4105BZU Histidine kinase HIS92_RS03310 ENOG41067SE Tetr family transcriptional regulator HIS92_RS03315 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HIS92_RS03325 ENOG4108VXD carboxy-peptidase HIS92_RS03330 ENOG4107DUR UPF0457 protein HIS92_RS03350 ENOG4105BZU Histidine kinase HIS92_RS03360 ENOG4105KT7 mgtC SapB transporter HIS92_RS03370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HIS92_RS03375 ENOG41073R8 VanW family HIS92_RS03385 ENOG4108R1P HIS92_RS03405 ENOG4105VEQ Cold shock protein HIS92_RS03425 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HIS92_RS03445 ENOG410904N short-chain dehydrogenase reductase HIS92_RS03455 ENOG4106IQC argininosuccinate lyase HIS92_RS03470 ENOG4108IA2 Sodium pantothenate symporter HIS92_RS03480 ENOG4105C26 Dehydrogenase HIS92_RS03485 ENOG4105CHR reductase HIS92_RS03495 ENOG4105EWU Squalene--hopene cyclase HIS92_RS03505 ENOG4105FR1 rard protein HIS92_RS03510 ENOG410696E Membrane HIS92_RS03525 ENOG4105D1F ATP-binding protein HIS92_RS03535 ENOG4108ZAF Molybdopterin HIS92_RS03540 ENOG4105CVM Molybdenum cofactor synthesis domain protein HIS92_RS03545 ENOG4105D06 uba thif-type nad fad binding protein HIS92_RS03550 ENOG4105TMB Formate nitrite transporter HIS92_RS03560 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HIS92_RS03565 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HIS92_RS03575 ENOG4108JB9 formate dehydrogenase HIS92_RS03650 ENOG4107QJT sodium dicarboxylate symporter HIS92_RS03655 ENOG4108KGH TRANSCRIPTIONal HIS92_RS03665 ENOG4105EMN RNA polymerase sigma factor HIS92_RS03675 ENOG4105CIG ABC transporter HIS92_RS03695 ENOG4105D9R oxidoreductase HIS92_RS03705 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HIS92_RS03710 ENOG4105K4P CoA-binding domain protein HIS92_RS03715 ENOG4105C0H protease HIS92_RS03720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS03730 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HIS92_RS03740 ENOG4105W8X HesB YadR YfhF-family protein HIS92_RS03765 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HIS92_RS03770 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HIS92_RS03780 ENOG4108JJB ABC transporter HIS92_RS03785 ENOG4108I0Z Aconitate hydratase HIS92_RS03815 ENOG4105E5W Transporter HIS92_RS03825 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HIS92_RS03845 ENOG4107F3J Amp-dependent synthetase and ligase HIS92_RS03850 ENOG4107ZYJ bioY protein HIS92_RS03855 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS03860 ENOG4108IMY Transcriptional regulator HIS92_RS03895 ENOG4107AYK membrAne HIS92_RS03905 ENOG4105BZU Histidine kinase HIS92_RS03910 ENOG4105FBA Phospholipase Carboxylesterase HIS92_RS03915 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HIS92_RS03920 ENOG4105CK7 Sodium proline symporter HIS92_RS03930 ENOG4105CBC glutamate synthase HIS92_RS03935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HIS92_RS03940 ENOG4108VJ1 Transcriptional regulator (CarD family HIS92_RS03945 ENOG4108903 Formimidoylglutamase HIS92_RS04000 ENOG4107QIV Cytochrome c biogenesis protein HIS92_RS04020 ENOG4105CJ1 ABC, transporter HIS92_RS04040 ENOG4107RSM transcriptional regulator HIS92_RS04050 ENOG41067MG lrgb family HIS92_RS04090 ENOG4105BZ1 (ABC) transporter HIS92_RS04095 ENOG4105BZ1 (ABC) transporter HIS92_RS04130 ENOG4108HW3 (ABC) transporter HIS92_RS04135 ENOG4105CGH 5'-nucleotidase HIS92_RS04145 ENOG4108SVB resolvase HIS92_RS04165 ENOG4105K7K Transcriptional regulator HIS92_RS04175 ENOG4105E4C Lytic transglycosylase catalytic HIS92_RS04180 ENOG41065S2 pneumococcal vaccine antigen HIS92_RS04215 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HIS92_RS04220 ENOG4105C5F glutamine synthetase HIS92_RS04225 ENOG4105KV4 Transcriptional regulator HIS92_RS04230 ENOG4105CXI aluminum resistance protein HIS92_RS04235 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HIS92_RS04240 ENOG4105EN6 Membrane HIS92_RS04250 ENOG4106F1P AAA ATPase, central domain protein HIS92_RS04280 ENOG41069ER domain protein HIS92_RS04285 ENOG4105DM4 PTS System HIS92_RS04290 ENOG4105DE4 1-phosphofructokinase HIS92_RS04295 ENOG4105E98 transcriptional regulator DeoR family HIS92_RS04300 ENOG4107QW4 alcohol dehydrogenase HIS92_RS04305 ENOG4108SJC Membrane HIS92_RS04315 ENOG4105C85 amino acid HIS92_RS04335 ENOG4105TMB Formate nitrite transporter HIS92_RS04340 ENOG4105K70 DNA-binding protein HIS92_RS04350 ENOG4105C59 p-type ATPase HIS92_RS04355 ENOG410681U heavy metal transport detoxification protein HIS92_RS04360 ENOG4105VPX protein, conserved in bacteria HIS92_RS04380 ENOG4105NIV Esterase HIS92_RS04385 ENOG4105E0A ABC, transporter HIS92_RS04405 ENOG4105CGK Exodeoxyribonuclease III HIS92_RS04415 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HIS92_RS04420 ENOG4105D03 DNA-3-methyladenine glycosylase II HIS92_RS04450 ENOG4105BZU Histidine kinase HIS92_RS04485 ENOG41067MG lrgb family HIS92_RS04505 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS04520 ENOG4105F0V Cell wall hydrolase HIS92_RS04530 ENOG4105E0M Sulfatase HIS92_RS04535 ENOG410890F Dynamin family HIS92_RS04570 ENOG4105DQU oxidoreductase, subunit beta HIS92_RS04575 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HIS92_RS04580 ENOG4108IGT Dipeptidase HIS92_RS04585 ENOG4105MCT stage V sporulation protein S HIS92_RS04590 ENOG4105D48 metallophosphoesterase HIS92_RS04610 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HIS92_RS04625 ENOG4105XZV Protein of unknown function (DUF3243) HIS92_RS04630 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HIS92_RS04650 ENOG4105UIB (ABC) transporter HIS92_RS04655 ENOG4108JQ9 ABC transporter HIS92_RS04660 ENOG4105DIH basic membrane HIS92_RS04665 ENOG4105FDP GntR family transcriptional regulator HIS92_RS04670 ENOG4105CNU cell division protein FtsK HIS92_RS04680 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HIS92_RS04690 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HIS92_RS04700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HIS92_RS04705 ENOG4108S0H Dipicolinic acid synthetase, b subunit HIS92_RS04710 ENOG4108IBT Inherit from COG: transposase HIS92_RS04830 ENOG4105VEQ Cold shock protein HIS92_RS04870 ENOG4105CDU Replicative dna helicase HIS92_RS04915 ENOG4108IMY Transcriptional regulator HIS92_RS04940 ENOG4105E35 Dipicolinate synthase subunit A HIS92_RS04950 ENOG4105C1V Peptidase, M16 HIS92_RS04970 ENOG4105DTN riboflavin biosynthesis protein ribF HIS92_RS04985 ENOG4105W7A Protein of unknown function (DUF503) HIS92_RS04995 ENOG4105VHM ribosomal protein HIS92_RS05000 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HIS92_RS05005 ENOG4105CHV Transcription elongation factor NusA HIS92_RS05015 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HIS92_RS05025 ENOG4105DZP Membrane-associated zinc metalloprotease HIS92_RS05030 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HIS92_RS05035 ENOG4105KNE Phosphatidate cytidylyltransferase HIS92_RS05040 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HIS92_RS05050 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HIS92_RS05080 ENOG4108HE4 integrase family HIS92_RS05090 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HIS92_RS05095 ENOG4105C79 DNA protecting protein DprA HIS92_RS05100 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HIS92_RS05115 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HIS92_RS05140 ENOG4105VB6 UPF0109 protein HIS92_RS05160 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HIS92_RS05165 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HIS92_RS05180 ENOG4105CHR reductase HIS92_RS05185 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HIS92_RS05200 ENOG4105CB5 ATP-dependent DNA helicase recG HIS92_RS05205 ENOG4105DP4 dak2 domain fusion protein ylov HIS92_RS05210 ENOG4108ZAA Alkaline-shock protein HIS92_RS05225 ENOG4105FJ0 thiamine HIS92_RS05230 ENOG4105DJV ribulose-phosphate 3-epimerase HIS92_RS05235 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HIS92_RS05240 ENOG4105D9P serine threonine protein kinase HIS92_RS05245 ENOG4108ZF3 Phosphatase HIS92_RS05255 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HIS92_RS05270 ENOG4105C25 Primosomal protein n' HIS92_RS05275 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HIS92_RS05295 ENOG4105DSJ YicC domain protein HIS92_RS05310 ENOG4105DC7 peptidase M24 HIS92_RS05390 ENOG4105C34 Pseudouridine synthase HIS92_RS05415 ENOG4105DBK s4 domain protein HIS92_RS05420 ENOG41067XK integral membrane protein HIS92_RS05430 ENOG4105DFA alanine racemase domain protein HIS92_RS05435 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HIS92_RS05440 ENOG4105WR5 sporulation protein, YlmC YmxH family HIS92_RS05450 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS05460 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HIS92_RS05465 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HIS92_RS05475 ENOG4105D4A Cell wall formation (By similarity) HIS92_RS05485 ENOG4105CNI cell division protein FtsW HIS92_RS05500 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HIS92_RS05505 ENOG4105CJN penicillin-binding protein HIS92_RS05510 ENOG4105CJN penicillin-binding protein HIS92_RS05550 ENOG4105KNH Nucleic acid-binding protein HIS92_RS05560 ENOG41063PX domain protein HIS92_RS05565 ENOG4105D78 K07001 NTE family protein HIS92_RS05570 ENOG4105H20 Sporulation integral membrane protein YlbJ HIS92_RS05580 ENOG4106H78 methyltransferase HIS92_RS05600 ENOG4107TB6 phosphoglycerate mutase HIS92_RS05615 ENOG4106UY4 Inherit from COG: Scp-like extracellular HIS92_RS05665 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HIS92_RS05670 ENOG4105CNI cell division protein FtsW HIS92_RS05685 ENOG4108IAB Phoh family HIS92_RS05705 ENOG4105QA2 HIS92_RS05710 ENOG4105CI3 gtp-binding protein typa HIS92_RS05720 ENOG4105ECY inositol monophosphatase HIS92_RS05740 ENOG4105CXN decarboxylase HIS92_RS05790 ENOG4105CPP Dehydrogenase, E1 component HIS92_RS05805 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HIS92_RS05810 ENOG4108X4Q Hydrolase HIS92_RS05820 ENOG4105CN5 Metallo-Beta-Lactamase HIS92_RS05825 ENOG4107ZYR domain protein HIS92_RS05860 ENOG4108XRC Protein of unknown function (DUF458) HIS92_RS05870 ENOG4107IN1 Protein of unknown function (DUF1797) HIS92_RS05885 ENOG4105EPM Diguanylate phosphodiesterase HIS92_RS05890 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HIS92_RS05915 ENOG4105UIN HIS92_RS05970 ENOG4108HGU Histidine kinase HIS92_RS05980 ENOG4105CHM Aminotransferase HIS92_RS05985 ENOG4105FKQ transcriptional regulator HIS92_RS05990 ENOG4105EG2 ABC transporter, permease HIS92_RS06000 ENOG4107FKK extracellular solute-binding protein family 1 HIS92_RS06010 ENOG4105CG3 alpha amylase, catalytic region HIS92_RS06055 ENOG4105CHU acetyl-coa acetyltransferase HIS92_RS06090 ENOG4105K7K Transcriptional regulator HIS92_RS06095 ENOG4105DTD Dehydrogenase HIS92_RS06115 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HIS92_RS06140 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HIS92_RS06155 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HIS92_RS06165 ENOG4105BZU Histidine kinase HIS92_RS06185 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HIS92_RS06200 ENOG4105CID antiterminator HIS92_RS06220 ENOG4105CE4 GlcNAc 6-P deacetylase HIS92_RS06255 ENOG4107ZE5 PPIases accelerate the folding of proteins HIS92_RS06260 ENOG4105PTM secreted protein HIS92_RS06265 ENOG4105J7I hydrolase HIS92_RS06275 ENOG4105G6R Stage v sporulation protein ae HIS92_RS06285 ENOG4105CZ3 stage V sporulation protein ad HIS92_RS06290 ENOG41090VF Stage v sporulation protein ac HIS92_RS06310 ENOG4105C8J )-transporter HIS92_RS06315 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS06325 ENOG41082AN stage II sporulation protein HIS92_RS06330 ENOG4105DZ1 carboxypeptidase HIS92_RS06335 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS06340 ENOG4105DVE abc transporter atp-binding protein HIS92_RS06375 ENOG4105D7N magnesium and cobalt transport protein CorA HIS92_RS06400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HIS92_RS06410 ENOG4105I3K Ferric uptake regulator, Fur family HIS92_RS06415 ENOG4105MZ9 stage II sporulation protein m HIS92_RS06435 ENOG4105CPC Aldo Keto reductase HIS92_RS06445 ENOG4105RHY Pfam:UPF0157 HIS92_RS06465 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HIS92_RS06475 ENOG4105ETE Transcriptional regulator (LacI family HIS92_RS06480 ENOG4108YM7 Gcn5-related n-acetyltransferase HIS92_RS06500 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HIS92_RS06505 ENOG4108R6K riboflavin synthase, subunit alpha HIS92_RS06530 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HIS92_RS06535 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HIS92_RS06550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HIS92_RS06560 ENOG4105DFD Na H antiporter HIS92_RS06565 ENOG4105CGH 5'-nucleotidase HIS92_RS06590 ENOG4105DBV ornithine carbamoyltransferase HIS92_RS06605 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HIS92_RS06620 ENOG4108IXY short-chain dehydrogenase reductase HIS92_RS06625 ENOG41069FQ Metallo-beta-lactamase superfamily HIS92_RS06630 ENOG4105II7 pyrroline-5-carboxylate reductase HIS92_RS06635 ENOG4105EJQ L-serine dehydratase HIS92_RS06665 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HIS92_RS06685 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HIS92_RS06690 ENOG4105D9U N-acetyltransferase HIS92_RS06705 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HIS92_RS06710 ENOG4108QEG Membrane HIS92_RS06715 ENOG4105CDA abc transporter atp-binding protein HIS92_RS06720 ENOG4105E5Q amino acid AbC transporter HIS92_RS06725 ENOG4108HW3 (ABC) transporter HIS92_RS06735 ENOG4105G7B Protein of unknown function (DUF2992) HIS92_RS06745 ENOG4108QY0 Membrane HIS92_RS06755 ENOG4105C7S Dehydrogenase HIS92_RS06760 ENOG4105CPP Dehydrogenase, E1 component HIS92_RS06780 ENOG4107RDP Dehydrogenase HIS92_RS06790 ENOG4108JUB Transcriptional regulator HIS92_RS06800 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HIS92_RS06850 ENOG4108C33 Resolvase HIS92_RS06885 ENOG4107QQR Sporulation HIS92_RS06890 ENOG4105S1Z Stage IV sporulation protein B HIS92_RS06895 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HIS92_RS06900 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HIS92_RS06905 ENOG4105DX0 Hemolysin A HIS92_RS06915 ENOG4105CTB Polyprenyl synthetase HIS92_RS06940 ENOG4108ZSR alkaline shock protein HIS92_RS06945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HIS92_RS06970 ENOG410644B Stage III sporulation protein af HIS92_RS06980 ENOG4105KQ4 Stage iii sporulation protein ad HIS92_RS06985 ENOG4108CQH stage III sporulation protein AC HIS92_RS06990 ENOG4105KR5 Stage iii sporulation protein HIS92_RS06995 ENOG4105CD2 stage iii sporulation protein aa HIS92_RS07020 ENOG4105DC7 peptidase M24 HIS92_RS07035 ENOG4105CBJ Metal-dependent enzyme HIS92_RS07045 ENOG4107YBY Hydrolase HIS92_RS07075 ENOG41082GG biotin lipoate A B protein ligase HIS92_RS07080 ENOG4105WZW rhodanese family HIS92_RS07105 ENOG41080TC multidrug resistance protein HIS92_RS07145 ENOG4105C0D helicase HIS92_RS07230 ENOG4107R6U sodium dicarboxylate symporter HIS92_RS07265 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HIS92_RS07270 ENOG4105C3R Methionine synthase HIS92_RS07280 ENOG4105C28 cystathionine HIS92_RS07285 ENOG4105C28 cystathionine HIS92_RS07305 ENOG4105C5X domain protein HIS92_RS07315 ENOG4105DKQ ROK family HIS92_RS07325 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HIS92_RS07340 ENOG4108UTW Plays a role in the regulation of phosphate uptake HIS92_RS07345 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS07350 ENOG4105C8U phosphate abc transporter HIS92_RS07355 ENOG4105C8U phosphate abc transporter HIS92_RS07365 ENOG4107RF6 penicillin-binding protein HIS92_RS07375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HIS92_RS07400 ENOG4105N80 Ferric uptake regulator, Fur family HIS92_RS07410 ENOG4105FDK ABC transporter HIS92_RS07415 ENOG4108JYZ YitT family HIS92_RS07420 ENOG41069ZM Protein of unknown function (DUF2624) HIS92_RS07445 ENOG4105EGD dinuclear metal center protein, YbgI family HIS92_RS07460 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS07465 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HIS92_RS07470 ENOG4107XJU UPF0178 protein HIS92_RS07495 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HIS92_RS07500 ENOG4105KG3 cytidine deaminase HIS92_RS07505 ENOG4107YR5 Diacylglycerol kinase HIS92_RS07515 ENOG4105CTJ Metal Dependent Phosphohydrolase HIS92_RS07520 ENOG4105C9A Phoh family HIS92_RS07530 ENOG41068P3 sporulation protein YqfC HIS92_RS07540 ENOG4105KTH gatB Yqey HIS92_RS07550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HIS92_RS07555 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HIS92_RS07585 ENOG4105CSA Coproporphyrinogen iii oxidase HIS92_RS07590 ENOG4105KVH Transcriptional regulator HIS92_RS07615 ENOG4105TQK DNA polymerase iii, delta' subunit HIS92_RS07625 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HIS92_RS07630 ENOG4108UK2 deaminase HIS92_RS07635 ENOG4105KQC Competence protein HIS92_RS07645 ENOG4105DXX methyltransferase HIS92_RS07655 ENOG4108WF2 Metal Dependent Phosphohydrolase HIS92_RS07665 ENOG410812S Rna-binding protein HIS92_RS07675 ENOG4105CQW ribosome biogenesis GTPase YqeH HIS92_RS07680 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HIS92_RS07695 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS07715 ENOG4108TVJ Nitroreductase HIS92_RS07730 ENOG4105G6Z alkaline phosphatase HIS92_RS07735 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HIS92_RS07740 ENOG4108MUZ hydrolase HIS92_RS07775 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HIS92_RS07780 ENOG4105MIR Phenylalanine 4-monooxygenase HIS92_RS07790 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HIS92_RS07830 ENOG4105S6R Iron-hydroxamate transporter permease subunit HIS92_RS07835 ENOG4108V5C ABC transporter HIS92_RS07845 ENOG4105C0A alcohol dehydrogenase HIS92_RS07850 ENOG4105C28 cystathionine HIS92_RS07880 ENOG4107XRG penicillin-binding protein HIS92_RS07890 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HIS92_RS07900 ENOG4105CFP Peptidase U32 HIS92_RS07905 ENOG4105XYU peptidase (U32 family) HIS92_RS07915 ENOG4105HHA aminodeoxychorismate lyase HIS92_RS07935 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HIS92_RS07945 ENOG4105C02 permease HIS92_RS07960 ENOG41060CR HIS92_RS07965 ENOG4105C7H Helicase, RecD TraA family HIS92_RS07975 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HIS92_RS07980 ENOG4105C3J Cysteine desulfurase HIS92_RS07990 ENOG4105D1H recombination factor protein RarA HIS92_RS07995 ENOG4108VCI transcription factor, rsfa family HIS92_RS08000 ENOG4105CUZ uba thif-type nad fad binding protein HIS92_RS08010 ENOG4105CUT histidyl-tRNA synthetase HIS92_RS08030 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HIS92_RS08040 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HIS92_RS08045 ENOG41076HS cation diffusion facilitator family transporter HIS92_RS08050 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HIS92_RS08060 ENOG4105CKP Polysaccharide Biosynthesis Protein HIS92_RS08065 ENOG4108QG2 Membrane HIS92_RS08075 ENOG4105VIE preprotein translocase, subunit YajC HIS92_RS08090 ENOG41061AI Protein of unknown function (DUF2905) HIS92_RS08105 ENOG4108HUF Transporter HIS92_RS08135 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HIS92_RS08140 ENOG4108IYU L-aspartate oxidase HIS92_RS08155 ENOG4108RPX mosc domain containing protein HIS92_RS08165 ENOG4105CQC Prephenate dehydratase HIS92_RS08185 ENOG4105EWM Histidine kinase HIS92_RS08210 ENOG4105X36 (ribosomal) protein HIS92_RS08220 ENOG4105C03 ribonuclease HIS92_RS08235 ENOG4107QMS site-determining protein HIS92_RS08255 ENOG4105DFF Rod shape-determining protein mreb HIS92_RS08275 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HIS92_RS08280 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HIS92_RS08290 ENOG41068KH stage VI sporulation protein D HIS92_RS08300 ENOG4105D52 delta-aminolevulinic acid dehydratase HIS92_RS08325 ENOG4105K56 Transcriptional regulator HIS92_RS08345 ENOG4108IUQ atp-dependent protease HIS92_RS08370 ENOG4108QCI YvbH-like oligomerisation region HIS92_RS08395 ENOG4105M59 Phosphodiesterase, mj0936 family HIS92_RS08410 ENOG4108XJQ germination protein HIS92_RS08420 ENOG4108PCX Major Facilitator HIS92_RS08430 ENOG4105KBX Transcriptional regulator, TetR family HIS92_RS08440 ENOG4105PFC Transcriptional regulator HIS92_RS08450 ENOG4105DZC cytosine deaminase HIS92_RS08455 ENOG41067S9 phage shock protein C, PspC HIS92_RS08460 ENOG4108JCI Transcriptional regulator HIS92_RS08470 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HIS92_RS08475 ENOG4108Z40 Transcriptional regulator HIS92_RS08480 ENOG4105RHA ABC transporter, permease HIS92_RS08485 ENOG4108IUX (ABC) transporter HIS92_RS08490 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HIS92_RS08495 ENOG4105ER2 Ompa motb domain protein HIS92_RS08500 ENOG4105E14 MotA TolQ exbB proton channel HIS92_RS08505 ENOG4108VXD carboxy-peptidase HIS92_RS08515 ENOG4105E33 succinate dehydrogenase HIS92_RS08525 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HIS92_RS08540 ENOG4105K63 Thioredoxin HIS92_RS08545 ENOG4105C10 Electron transfer flavoprotein HIS92_RS08550 ENOG4105BZJ Electron transfer flavoprotein HIS92_RS08555 ENOG41060WC Enoyl-CoA hydratase HIS92_RS08560 ENOG4107Z3H Transcriptional regulator, TetR family HIS92_RS08565 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS08575 ENOG4105J76 Periplasmic binding protein HIS92_RS08580 ENOG4105S6R Iron-hydroxamate transporter permease subunit HIS92_RS08620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HIS92_RS08635 ENOG4105DR4 Methyltransferase HIS92_RS08645 ENOG4105KFN sortase, SrtB family HIS92_RS08650 ENOG4105E0A ABC, transporter HIS92_RS08665 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HIS92_RS08675 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HIS92_RS08685 ENOG4105FE9 pseudouridine synthase HIS92_RS08695 ENOG4105DCG PHP domain protein HIS92_RS08710 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HIS92_RS08730 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HIS92_RS08740 ENOG4108RWN rrna methyltransferase HIS92_RS08765 ENOG4105C0R drug resistance transporter emrb qaca subfamily HIS92_RS08770 ENOG4105CW7 secretion protein, HlyD family HIS92_RS08775 ENOG4108JGH Tetr family transcriptional regulator HIS92_RS08780 ENOG4105CN9 Peptidase m42 family protein HIS92_RS08800 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HIS92_RS08805 ENOG4105C22 threonyL-tRNA synthetase HIS92_RS08810 ENOG4108TDW sporulation protein YtxC HIS92_RS08840 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HIS92_RS08845 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HIS92_RS08855 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HIS92_RS08860 ENOG4105C2M dna polymerase I HIS92_RS08865 ENOG4105BZU Histidine kinase HIS92_RS08870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HIS92_RS08890 ENOG4108HMX isocitrate dehydrogenase (NADP) HIS92_RS08895 ENOG4105BZN citrate synthase HIS92_RS08905 ENOG4108REF Sporulation integral membrane protein ytvi HIS92_RS08910 ENOG4105FS0 cytoplasmic membrane protein HIS92_RS08935 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS08940 ENOG4105C6K Malic enzyme HIS92_RS08945 ENOG4105C0B DNA polymerase III (alpha subunit) HIS92_RS08950 ENOG4105VV2 HIS92_RS08960 ENOG4105SFS phosphoesterase RecJ domain protein HIS92_RS08990 ENOG4105DC7 peptidase M24 HIS92_RS09025 ENOG4105Z7P Acetyltransferase (GNAT) family HIS92_RS09030 ENOG41082W1 Cupin 2, conserved barrel domain protein HIS92_RS09050 ENOG4107YZX Universal stress protein HIS92_RS09090 ENOG4108JYZ YitT family HIS92_RS09110 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HIS92_RS09120 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HIS92_RS09125 ENOG4105KBJ sporulation protein ytfj HIS92_RS09140 ENOG4105EFZ amidohydrolase HIS92_RS09150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HIS92_RS09175 ENOG4107RSM transcriptional regulator HIS92_RS09185 ENOG4105U5Y Transcriptional regulator HIS92_RS09195 ENOG4105C28 cystathionine HIS92_RS09220 ENOG4108UW5 maltose o-acetyltransferase HIS92_RS09230 ENOG4105F1V Acetoin utilization protein HIS92_RS09235 ENOG4105W87 Cbs domain HIS92_RS09240 ENOG4105DGU Histone deacetylase HIS92_RS09255 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HIS92_RS09260 ENOG4105BZU Histidine kinase HIS92_RS09265 ENOG4107SNB ankyrin repeat protein YahD HIS92_RS09270 ENOG4105EP9 oxidoreductase HIS92_RS09300 ENOG4105ETE Transcriptional regulator (LacI family HIS92_RS09310 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HIS92_RS09315 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HIS92_RS09335 ENOG4105C88 aminopeptidase HIS92_RS09355 ENOG4108IPJ Membrane HIS92_RS09380 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HIS92_RS09390 ENOG4108VDD TRNA binding domain protein HIS92_RS09420 ENOG4105C8F Beta-lactamase domain protein HIS92_RS09435 ENOG4108V15 phosphotransferase enzyme family HIS92_RS09440 ENOG4108IUM Glycogen debranching enzyme HIS92_RS09450 ENOG4107QSE Dipeptidase HIS92_RS09455 ENOG4105YW5 deoR family transcriptional regulator HIS92_RS09470 ENOG4105CBX hi0933 family HIS92_RS09505 ENOG4108VJ1 Transcriptional regulator (CarD family HIS92_RS09510 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HIS92_RS09515 ENOG4105CSC Glucose uptake protein HIS92_RS09530 ENOG4108ZAF Molybdopterin HIS92_RS09535 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HIS92_RS09540 ENOG4105CVM Molybdenum cofactor synthesis domain protein HIS92_RS09550 ENOG4105D06 uba thif-type nad fad binding protein HIS92_RS09555 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HIS92_RS09575 ENOG41085GJ domain protein HIS92_RS09585 ENOG4105DWV Homoserine O-trans-acetylase HIS92_RS09625 ENOG410605W Major Facilitator HIS92_RS09630 ENOG4107S91 Sodium hydrogen exchanger HIS92_RS09635 ENOG4105NCW Trka-c domain protein HIS92_RS09650 ENOG4105C19 ABC transporter HIS92_RS09670 ENOG4105N5T Radical SAM Protein HIS92_RS09695 ENOG4105E8V Alpha Beta Hydrolase Fold protein HIS92_RS09700 ENOG4108Z0R Transferase HIS92_RS09705 ENOG4105YVM Phosphoesterase, PA-phosphatase related HIS92_RS09710 ENOG4105BZF Glycosyl transferase (Group 1 HIS92_RS09720 ENOG4105EPU Molybdenum cofactor synthesis domain protein HIS92_RS09805 ENOG4105BZU Histidine kinase HIS92_RS09810 ENOG4105BZU Histidine kinase HIS92_RS09815 ENOG4105CH6 catalase HIS92_RS09820 ENOG4107S9D Alpha beta hydrolase HIS92_RS09825 ENOG4107T7U Sulfatase HIS92_RS09850 ENOG4105D2X ABC transporter substrate-binding protein HIS92_RS09860 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HIS92_RS09915 ENOG41080TC multidrug resistance protein HIS92_RS09920 ENOG410839T multidrug resistance protein HIS92_RS09940 ENOG4108V2W Carbonate dehydratase HIS92_RS09945 ENOG4105C4M (Ubiquinol oxidase) subunit I HIS92_RS09950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HIS92_RS09995 ENOG41087YS Phage shock protein A HIS92_RS10020 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HIS92_RS10025 ENOG4105BZU Histidine kinase HIS92_RS10030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS10055 ENOG4108UGV hypoxanthine phosphoribosyltransferase HIS92_RS10060 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HIS92_RS10110 ENOG4105BZU Histidine kinase HIS92_RS10120 ENOG4107ZTW SNARE associated Golgi HIS92_RS10135 ENOG4105C19 ABC transporter HIS92_RS10140 ENOG41086D8 Transcriptional regulator HIS92_RS10150 ENOG4105CJ1 ABC, transporter HIS92_RS10160 ENOG41082BM Transcriptional regulator, arsr family HIS92_RS10205 ENOG4105C6Z Gluconate HIS92_RS10230 ENOG41069H0 dihydroorotase EC 3.5.2.3 HIS92_RS10250 ENOG4105DTQ mandelate racemase muconate lactonizing HIS92_RS10260 ENOG4108IPT Naphthoate synthase HIS92_RS10265 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HIS92_RS10275 ENOG4105E4F Isochorismate synthase HIS92_RS10280 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HIS92_RS10290 ENOG4105VEQ Cold shock protein HIS92_RS10355 ENOG4108Q5F Tetr family transcriptional regulator HIS92_RS10490 ENOG4105KT7 mgtC SapB transporter HIS92_RS10495 ENOG4107PBV potassium channel HIS92_RS10510 ENOG4105WG9 Conserved Protein HIS92_RS10520 ENOG4105CHM Aminotransferase HIS92_RS10525 ENOG4108ZB6 transcriptional regulator AsnC family HIS92_RS10530 ENOG4105C5I Dehydrogenase HIS92_RS10535 ENOG4108MUZ hydrolase HIS92_RS10545 ENOG4105C87 Aminotransferase class I and II HIS92_RS10560 ENOG4105Y38 Kinase-associated protein B HIS92_RS10570 ENOG4107R3E Citrate transporter HIS92_RS10590 ENOG4105KA0 thioesterase Superfamily protein HIS92_RS10605 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HIS92_RS10625 ENOG41069ER domain protein HIS92_RS10640 ENOG4105CEP NADH dehydrogenase HIS92_RS10665 ENOG4105EWC Purine nucleoside phosphorylase HIS92_RS10695 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HIS92_RS10720 ENOG4108JJA ABC, transporter HIS92_RS10725 ENOG4105C4B ABC transporter, permease HIS92_RS10730 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HIS92_RS10775 ENOG41083MR nifu domain-containing protein HIS92_RS10790 ENOG4108W5N phosphatidylglycerophosphatase a HIS92_RS10810 ENOG4105DAX Pfam:DUF2983 HIS92_RS10820 ENOG4105DYS nad(p)h dehydrogenase (quinone) HIS92_RS10825 ENOG4105D4U had-superfamily hydrolase, subfamily iia HIS92_RS10840 ENOG4105CBT Fructose-1,6-bisphosphatase HIS92_RS10855 ENOG4105MMD transcriptional regulator HIS92_RS10860 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HIS92_RS10865 ENOG4107TXC Transcriptional regulator HIS92_RS10870 ENOG41090T1 Membrane HIS92_RS10895 ENOG4105FAA peptidase M23 HIS92_RS10900 ENOG4108YTE sporulation protein YunB HIS92_RS10905 ENOG4105KZD Domain of unknown function (DUF1805) HIS92_RS10910 ENOG4107R8B 5'-nucleotidase HIS92_RS10915 ENOG4105DIW FeS assembly protein SUFB HIS92_RS10920 ENOG4108UNV SUF system FeS assembly protein, NifU family HIS92_RS10925 ENOG4105C9B Cysteine desulfurase HIS92_RS10930 ENOG4105JRK feS assembly protein SufD HIS92_RS10935 ENOG4105C3K feS assembly ATPase SufC HIS92_RS10940 ENOG4105D01 (LipO)protein HIS92_RS10945 ENOG4105D01 (LipO)protein HIS92_RS10950 ENOG4108UMI ABC transporter, permease HIS92_RS10955 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS10980 ENOG41080E8 Transcriptional regulator, Spx MgsR family HIS92_RS11000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HIS92_RS11015 ENOG4108W8B Beta-lactamase domain protein HIS92_RS11020 ENOG4105C1G acyl-Coa dehydrogenase HIS92_RS11025 ENOG4105CHU acetyl-coa acetyltransferase HIS92_RS11040 ENOG4105DZ1 carboxypeptidase HIS92_RS11060 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HIS92_RS11075 ENOG4108SUT Major Facilitator Superfamily HIS92_RS11080 ENOG4107R7I amino acid HIS92_RS11095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HIS92_RS11105 ENOG4107AYK membrAne HIS92_RS11140 ENOG4107ZTW SNARE associated Golgi HIS92_RS11150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HIS92_RS11155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS11160 ENOG4105BZU Histidine kinase HIS92_RS11185 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS11190 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS11195 ENOG4105VG1 fes assembly suf system protein HIS92_RS11205 ENOG4105D4Y metalloprotease HIS92_RS11210 ENOG4105C2I pirin domain protein HIS92_RS11225 ENOG4107T5V SNARE associated Golgi HIS92_RS11230 ENOG4107S91 Sodium hydrogen exchanger HIS92_RS11235 ENOG4105NCW Trka-c domain protein HIS92_RS11245 ENOG4108RMU ferritin dps family protein HIS92_RS11260 ENOG4108URH decarboxylase HIS92_RS11270 ENOG41090A1 ferritin HIS92_RS11280 ENOG4105D9N nucleoside HIS92_RS11285 ENOG4105D9N nucleoside HIS92_RS11300 ENOG4108RYK Nad-dependent epimerase dehydratase HIS92_RS11315 ENOG4105CV8 reductase HIS92_RS11320 ENOG4105F27 Major Facilitator HIS92_RS11325 ENOG4105KVH Transcriptional regulator HIS92_RS11340 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HIS92_RS11345 ENOG4105D4A Cell wall formation (By similarity) HIS92_RS11355 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS11370 ENOG4105WMR Protein CrcB homolog HIS92_RS11390 ENOG4105C5H ABC transporter HIS92_RS11395 ENOG4108MK9 spermidine N(1)-acetyltransferase HIS92_RS11415 ENOG4108W2Y isochorismatase HIS92_RS11435 ENOG4108V2W Carbonate dehydratase HIS92_RS11440 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HIS92_RS11455 ENOG4108IPW abc transporter atp-binding protein HIS92_RS11460 ENOG4105CM4 permease protein HIS92_RS11475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS11490 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HIS92_RS11500 ENOG4105XZU Preprotein translocase, subunit SecG HIS92_RS11505 ENOG41067MG lrgb family HIS92_RS11555 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS11575 ENOG41090VF Stage v sporulation protein ac HIS92_RS11580 ENOG4105CZ3 stage V sporulation protein ad HIS92_RS11595 ENOG4108QY0 Membrane HIS92_RS11605 ENOG4105KRI phosphocarrier protein (HPr HIS92_RS11615 ENOG4105CHW UPF0052 protein HIS92_RS11625 ENOG4108Z4K mutator MutT protein HIS92_RS11635 ENOG4105C3M thioredoxin reductase HIS92_RS11645 ENOG4108S4C acetyltransferase HIS92_RS11665 ENOG41086DT Membrane protein of unknown function HIS92_RS11675 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HIS92_RS11695 ENOG4107TXC Transcriptional regulator HIS92_RS11710 ENOG4105HMI Membrane HIS92_RS11715 ENOG4105DUM transcriptional regulator, lysR family HIS92_RS11725 ENOG4108WS4 fmn reductase HIS92_RS11730 ENOG4105C5H ABC transporter HIS92_RS11740 ENOG4105BZ1 (ABC) transporter HIS92_RS11750 ENOG4105CN1 protease HIS92_RS11755 ENOG4105CRP Part of the ABC transporter FtsEX involved in HIS92_RS11760 ENOG4105CAK Cell division ATP-binding protein ftsE HIS92_RS11780 ENOG4105MS2 ribosomal subunit Interface protein HIS92_RS11785 ENOG4105VEQ Cold shock protein HIS92_RS11790 ENOG41081UC Inherit from COG: Competence protein HIS92_RS11805 ENOG4105KVH Transcriptional regulator HIS92_RS11815 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HIS92_RS11820 ENOG4108KGH TRANSCRIPTIONal HIS92_RS11825 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HIS92_RS11830 ENOG4105C6Y Udp-glucose 6-dehydrogenase HIS92_RS11835 ENOG4105ESV Glycosyl transferase, family 4 HIS92_RS11845 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HIS92_RS11865 ENOG4105F8D glycoside hydrolase family 4 HIS92_RS11870 ENOG4105VCP PTS System HIS92_RS11875 ENOG4105CK1 PTS System HIS92_RS11885 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HIS92_RS11890 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HIS92_RS11895 ENOG4105VCP PTS System HIS92_RS11905 ENOG4105VZJ PTS System HIS92_RS11925 ENOG4105ECB domain protein HIS92_RS11930 ENOG4107RSM transcriptional regulator HIS92_RS11965 ENOG4105DAA L-lactate HIS92_RS11975 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HIS92_RS11985 ENOG4105E0M Sulfatase HIS92_RS12010 ENOG4107R8N Glycosyl transferase, family 2 HIS92_RS12015 ENOG4105C94 Transporter HIS92_RS12020 ENOG41069ER domain protein HIS92_RS12045 ENOG4105KBK Zinc finger, swim domain protein HIS92_RS12050 ENOG4105C0D helicase HIS92_RS12080 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS12090 ENOG4107RBB ABC transporter, permease HIS92_RS12095 ENOG4105C19 ABC transporter HIS92_RS12115 ENOG4105CXY transporter HIS92_RS12130 ENOG4105BZU Histidine kinase HIS92_RS12135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS12150 ENOG4105CMR udp-glucose 4-epimerase HIS92_RS12155 ENOG4105C6Y Udp-glucose 6-dehydrogenase HIS92_RS12165 ENOG4105CPK Glycosyl transferase (Group 1 HIS92_RS12180 ENOG4105D3Q Sugar transferase HIS92_RS12185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HIS92_RS12190 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HIS92_RS12195 ENOG4107YJ4 chain length determinant protein HIS92_RS12200 ENOG4105HTX biosynthesis protein HIS92_RS12205 ENOG4107YJ4 chain length determinant protein HIS92_RS12220 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HIS92_RS12230 ENOG4105FRN stage II sporulation protein HIS92_RS12245 ENOG4105DY9 regulatoR HIS92_RS12265 ENOG4106778 Protein of unknown function (DUF1146) HIS92_RS12270 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HIS92_RS12275 ENOG4105C8S subunit m HIS92_RS12280 ENOG4105D65 subunit l HIS92_RS12305 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HIS92_RS12310 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HIS92_RS12320 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HIS92_RS12325 ENOG4105BZU Histidine kinase HIS92_RS12375 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HIS92_RS12380 ENOG41062M3 atp synthase HIS92_RS12405 ENOG4108UIC UPF0340 protein HIS92_RS12410 ENOG4108YZG isomerase HIS92_RS12425 ENOG4108VGI doxx family HIS92_RS12430 ENOG4107XC4 flavin reductase domain protein, FMN-binding HIS92_RS12450 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HIS92_RS12460 ENOG4108ZXQ stage ii sporulation protein r HIS92_RS12465 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HIS92_RS12485 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HIS92_RS12490 ENOG4105CBT Fructose-1,6-bisphosphatase HIS92_RS12495 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HIS92_RS12530 ENOG4105C1G acyl-Coa dehydrogenase HIS92_RS12535 ENOG4105C1G acyl-Coa dehydrogenase HIS92_RS12540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HIS92_RS12550 ENOG4105DF6 Fe-S oxidoreductase HIS92_RS12555 ENOG41067QW Transcriptional regulator HIS92_RS12595 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HIS92_RS12600 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) HIS92_RS12655 ENOG4105BZU Histidine kinase HIS92_RS12670 ENOG4105D4Y metalloprotease HIS92_RS12680 ENOG4105BZU Histidine kinase HIS92_RS12685 ENOG4105KCT ABC transporter HIS92_RS12690 ENOG4108M15 ABC transporter HIS92_RS12695 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HIS92_RS12705 ENOG4105IIU Aminopeptidase HIS92_RS12725 ENOG4105EMN RNA polymerase sigma factor HIS92_RS12735 ENOG410684U Domain of unknown function (DUF1934) HIS92_RS12755 ENOG4105CYW agmatinase HIS92_RS12765 ENOG4105DXB Major Facilitator superfamily HIS92_RS12770 ENOG4107SWG transcriptional regulator MERR family HIS92_RS12775 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HIS92_RS12780 ENOG4105BZ4 penicillin-binding protein HIS92_RS12785 ENOG4108XFG YwhD family HIS92_RS12790 ENOG4108Z4T Peptidase M50 HIS92_RS12795 ENOG41069HH 4-oxalocrotonate tautomerase HIS92_RS12800 ENOG4105DCI Phosphohydrolase HIS92_RS12805 ENOG4108MES Periplasmic binding protein HIS92_RS12810 ENOG4105E0A ABC, transporter HIS92_RS12815 ENOG4105EHG Permease protein HIS92_RS12820 ENOG4105DQ5 transport system permease protein HIS92_RS12830 ENOG4108VCI transcription factor, rsfa family HIS92_RS12835 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HIS92_RS12840 ENOG4108IJ2 phosphate acetyltransferase HIS92_RS12855 ENOG4108VKI Cell wall hydrolase HIS92_RS12875 ENOG4107SVH Potassium channel protein HIS92_RS12885 ENOG410667J hydrolase HIS92_RS12890 ENOG4105VCH membrane HIS92_RS12900 ENOG4108TU7 Inherit from COG: (ABC) transporter HIS92_RS12905 ENOG4105CJ1 ABC, transporter HIS92_RS12910 ENOG41090WU lipolytic protein G-D-S-L family HIS92_RS12925 ENOG4105D6E homoserine dehydrogenase HIS92_RS12945 ENOG4108Y4K DNA-binding transcriptional activator HIS92_RS12955 ENOG4105WH1 Two component transcriptional regulator luxr family HIS92_RS12960 ENOG4105BZU Histidine kinase HIS92_RS12965 ENOG4105DWF phosphomethylpyrimidine kinase HIS92_RS12970 ENOG4105BZU Histidine kinase HIS92_RS12975 ENOG4105VCD cytoplasmic protein HIS92_RS12980 ENOG4105D22 carbon starvation protein HIS92_RS12985 ENOG4105DY9 regulatoR HIS92_RS12990 ENOG41079KZ Major Facilitator Superfamily HIS92_RS13000 ENOG4105CG5 Glycosyl transferase (Group 1 HIS92_RS13010 ENOG4105EN6 Membrane HIS92_RS13015 ENOG4106YBV Methyl-accepting chemotaxis HIS92_RS13025 ENOG4108S4H thioesterase Superfamily protein HIS92_RS13030 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HIS92_RS13045 ENOG4105K64 Glycosyl transferase, family 2 HIS92_RS13055 ENOG4105EJV Membrane HIS92_RS13060 ENOG4105CKK Glycosyl transferase, family 2 HIS92_RS13070 ENOG4107XI7 Tetr family transcriptional regulator HIS92_RS13075 ENOG4105C5H ABC transporter HIS92_RS13080 ENOG41067SE Tetr family transcriptional regulator HIS92_RS13090 ENOG4105E0X reductase HIS92_RS13095 ENOG4106F5Q Membrane HIS92_RS13110 ENOG4108NEV two component transcriptional regulator, LytTR family HIS92_RS13115 ENOG4108HRK Histidine kinase HIS92_RS13120 ENOG4107RGD Major Facilitator superfamily HIS92_RS13135 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HIS92_RS13145 ENOG4105IW1 AmiS UreI transporter HIS92_RS13155 ENOG4105CMR udp-glucose 4-epimerase HIS92_RS13160 ENOG4108UT2 hemolysin iii HIS92_RS13170 ENOG4105C1J atp-dependent rna helicase HIS92_RS13175 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HIS92_RS13180 ENOG4105DPN Oligoendopeptidase f HIS92_RS13200 ENOG4107Y5K Resolvase HIS92_RS13250 ENOG4107Y5K Resolvase HIS92_RS13255 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HIS92_RS13300 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HIS92_RS13315 ENOG4105C0H protease HIS92_RS13320 ENOG4105Q2H domain protein HIS92_RS13335 ENOG4105BZU Histidine kinase HIS92_RS13340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS13365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HIS92_RS13370 ENOG4105CDU Replicative dna helicase HIS92_RS13380 ENOG4105BZR domain protein HIS92_RS13385 ENOG4108XMW Membrane HIS92_RS13395 ENOG4108UUM single-stranded DNA-binding protein HIS92_RS13405 ENOG4105C3G gtp-binding protein HIS92_RS13410 ENOG4105VDK protein, conserved in bacteria HIS92_RS13415 ENOG4105D8X mechanosensitive ion channel HIS92_RS13420 ENOG4108ZDA Sporulation protein YyaC HIS92_RS13425 ENOG4105FA0 parb-like partition protein HIS92_RS13430 ENOG4107QJE Chromosome Partitioning Protein HIS92_RS13450 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HIS92_RS13460 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HIS92_RS13480 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HIS92_RS13485 ENOG410848D S4 domain protein YaaA HIS92_RS13500 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HIS92_RS13535 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HIS92_RS13570 ENOG4105ZMH deoxynucleoside kinase HIS92_RS13580 ENOG4105GTG Isochorismatase HIS92_RS13585 ENOG4108Z6B deaminase HIS92_RS13595 ENOG4105C6E dna polymerase iii HIS92_RS13615 ENOG41067KS pro-sigma K processing HIS92_RS13650 ENOG4105CXN decarboxylase HIS92_RS13660 ENOG4105FA2 dna polymerase iii HIS92_RS13665 ENOG4105MA4 psp1 domain protein HIS92_RS13675 ENOG41060K3 Methyltransferase HIS92_RS13685 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HIS92_RS13690 ENOG4105KRN Transcriptional regulator, abrb family HIS92_RS13695 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HIS92_RS13700 ENOG4105F8V Hydrolase, tatD family HIS92_RS13705 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HIS92_RS13715 ENOG4105XFA sporulation peptidase YabG HIS92_RS13720 ENOG4105W42 Veg protein HIS92_RS13735 ENOG4105DFT pur operon repressor HIS92_RS13740 ENOG4105KME endoribonuclease L-psp HIS92_RS13760 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HIS92_RS13770 ENOG4108JA2 transcriptioN-repair coupling factor HIS92_RS13775 ENOG4108M14 stage v sporulation protein t HIS92_RS13785 ENOG4108IY2 MazG family HIS92_RS13790 ENOG41082I2 s4 domain protein HIS92_RS13795 ENOG4105VYY sporulation protein yabp HIS92_RS13810 ENOG41060GV RNA binding s1 domain protein HIS92_RS13830 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HIS92_RS13835 ENOG4108UGV hypoxanthine phosphoribosyltransferase HIS92_RS13840 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HIS92_RS13855 ENOG4105C6T cysteine synthase HIS92_RS13860 ENOG4105CRQ synthase (Component I) HIS92_RS13865 ENOG4105DDQ anthranilate synthase HIS92_RS13870 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HIS92_RS13875 ENOG4105EEI dihydropteroate synthase HIS92_RS13880 ENOG4105KRF dihydroneopterin aldolase HIS92_RS13885 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HIS92_RS13895 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HIS92_RS13925 ENOG4108Z0C Uvrb UvrC protein HIS92_RS13940 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HIS92_RS13950 ENOG4105CTP PilT protein domain protein HIS92_RS13970 ENOG4105D7W serine acetyltransferase HIS92_RS13985 ENOG4105C2N RNA methyltransferase TrmH family group 3 HIS92_RS13990 ENOG4105M0M Tetracycline resistance protein HIS92_RS13995 ENOG4105QIV RNA polymerase HIS92_RS14010 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HIS92_RS14035 ENOG4107Y49 methyltransferase HIS92_RS14050 ENOG4105XPM ribosomal protein HIS92_RS14180 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HIS92_RS14190 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HIS92_RS14225 ENOG4108JJB ABC transporter HIS92_RS14230 ENOG4108JJB ABC transporter HIS92_RS14235 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HIS92_RS14240 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HIS92_RS14265 ENOG4105D1F ATP-binding protein HIS92_RS14280 ENOG4108NMV polysaccharide deacetylase HIS92_RS14360 ENOG4105C8B TIGR00159 family HIS92_RS14365 ENOG4107U5W ybbr family HIS92_RS14380 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HIS92_RS14400 ENOG4108PSK reductase HIS92_RS14405 ENOG4108UMI ABC transporter, permease HIS92_RS14410 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS14415 ENOG4105D01 (LipO)protein HIS92_RS14420 ENOG4105CB2 alcohol dehydrogenase HIS92_RS14430 ENOG4105IQ5 FAD linked oxidase domain protein HIS92_RS14445 ENOG4105C2C drug resistance transporter, Bcr CflA HIS92_RS14465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HIS92_RS14470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HIS92_RS14475 ENOG4105C3U ABC transporter HIS92_RS14480 ENOG4108JQ7 (ABC) transporter HIS92_RS14500 ENOG4108J59 Extracellular solute-binding protein, family 5 HIS92_RS14525 ENOG4105E0C molybdate abc transporter HIS92_RS14530 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HIS92_RS14535 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HIS92_RS14565 ENOG4105F6E Acyl-transferase HIS92_RS14585 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HIS92_RS14600 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HIS92_RS14620 ENOG4105C5H ABC transporter HIS92_RS14630 ENOG4105DEF Extracellular solute-binding protein, family 5 HIS92_RS14640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HIS92_RS14645 ENOG4105C3U ABC transporter HIS92_RS14650 ENOG4108JQ7 (ABC) transporter HIS92_RS14655 ENOG410667J hydrolase HIS92_RS14680 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HIS92_RS14685 ENOG4105ERH Fumarylacetoacetate hydrolase HIS92_RS14695 ENOG4105CUB amino acid HIS92_RS14700 ENOG4108SC4 )-transporter HIS92_RS14705 ENOG4105CPF Cell wall formation (By similarity) HIS92_RS14710 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HIS92_RS14735 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HIS92_RS14740 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HIS92_RS14750 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HIS92_RS14855 ENOG4105K8N protein family UPF0079, ATPase HIS92_RS14860 ENOG41072GX Peptidase M22 Glycoprotease HIS92_RS14865 ENOG410801F ribosomal-protein-alanine acetyltransferase HIS92_RS14870 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HIS92_RS14875 ENOG4105C5H ABC transporter HIS92_RS14890 ENOG4108TYN CAAX amino terminal protease family protein HIS92_RS14980 ENOG4108IBT Inherit from COG: transposase HIS92_RS15025 ENOG4106BHR ftsk SpoIIIE family protein HIS92_RS15035 ENOG4106128 DNA-binding helix-turn-helix protein HIS92_RS15050 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HIS92_RS15060 ENOG4105C7N Xanthine uracil vitamin C permease HIS92_RS15070 ENOG4105BZU Histidine kinase HIS92_RS15095 ENOG4107ZXU DSBA oxidoreductase HIS92_RS15140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HIS92_RS15160 ENOG410631K Membrane HIS92_RS15185 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HIS92_RS15190 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HIS92_RS15195 ENOG4105C83 adenylosuccinate lyase HIS92_RS15205 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HIS92_RS15230 ENOG4108V3E phosphoribosylglycinamide formyltransferase HIS92_RS15240 ENOG4105C12 Phosphoribosylglycinamide synthetase HIS92_RS15265 ENOG4105C4R Atp-dependent dna helicase HIS92_RS15290 ENOG4108W2Y isochorismatase HIS92_RS15295 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS15300 ENOG4108UMI ABC transporter, permease HIS92_RS15305 ENOG4105D01 (LipO)protein HIS92_RS15325 ENOG410834F Transcriptional regulator HIS92_RS15330 ENOG4107I77 yiaA/B two helix domain HIS92_RS15350 ENOG4105CBD Diacylglycerol kinase HIS92_RS15355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HIS92_RS15360 ENOG4108JPW Aminotransferase HIS92_RS15370 ENOG4105C26 Dehydrogenase HIS92_RS15375 ENOG4105KPY Small multidrug resistance protein HIS92_RS15400 ENOG4105D9N nucleoside HIS92_RS15405 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HIS92_RS15415 ENOG4108W15 Protein of unknown function (DUF1456) HIS92_RS15430 ENOG4105DTQ mandelate racemase muconate lactonizing HIS92_RS15440 ENOG4105DFD Na H antiporter HIS92_RS15460 ENOG4105D3R alkyl hydroperoxide reductase HIS92_RS15485 ENOG4105EHG Permease protein HIS92_RS15490 ENOG4105DQ5 transport system permease protein HIS92_RS15495 ENOG4108V5C ABC transporter HIS92_RS15515 ENOG4106UIA HIS92_RS15520 ENOG4106UIA HIS92_RS15535 ENOG4105BZU Histidine kinase HIS92_RS15555 ENOG410756H nucleotidyltransferase HIS92_RS15560 ENOG4105D2S major facilitator superfamily HIS92_RS15575 ENOG4105E5Q amino acid AbC transporter HIS92_RS15580 ENOG4105EAB amino acid AbC transporter HIS92_RS15585 ENOG4105CDA abc transporter atp-binding protein HIS92_RS15590 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS15605 ENOG4105DBV ornithine carbamoyltransferase HIS92_RS15615 ENOG4105C5B carbamate kinase HIS92_RS15620 ENOG4108W63 CRP FNR family transcriptional regulator HIS92_RS15630 ENOG4105DNP FAD linked oxidase domain protein HIS92_RS15640 ENOG4105CI1 PTS System HIS92_RS15655 ENOG4105C9U ATP-dependent DNA helicase RecQ HIS92_RS15670 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HIS92_RS15690 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HIS92_RS15695 ENOG4105D2X ABC transporter substrate-binding protein HIS92_RS15705 ENOG4105C5H ABC transporter HIS92_RS15735 ENOG41062JF Transcriptional regulator HIS92_RS15750 ENOG4105DEU major facilitator superfamily HIS92_RS15780 ENOG4108N0M stress protein HIS92_RS15785 ENOG4106FN3 tellurium resistance protein HIS92_RS15790 ENOG4106FN3 tellurium resistance protein HIS92_RS15795 ENOG4107TS3 membrane protein, TerC HIS92_RS15800 ENOG4108TTB tellurium resistance protein HIS92_RS15820 ENOG4105KJF protein tyrosine phosphatase HIS92_RS15830 ENOG4107U9T Pfam:Ribonuclease_BN HIS92_RS15835 ENOG4105C59 p-type ATPase HIS92_RS15840 ENOG4108IPJ Membrane HIS92_RS15850 ENOG4105C3F Signal peptidase i HIS92_RS15860 ENOG4107ZTW SNARE associated Golgi HIS92_RS15875 ENOG410606W general stress protein HIS92_RS15880 ENOG4105UPD Calcium Proton HIS92_RS15915 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HIS92_RS15925 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HIS92_RS15935 ENOG4108JUB Transcriptional regulator HIS92_RS15945 ENOG4108IQI permease HIS92_RS15985 ENOG4108A04 Beta-lactamase HIS92_RS16000 ENOG4105CKK Glycosyl transferase, family 2 HIS92_RS16005 ENOG4107QQG Dehydrogenase HIS92_RS16010 ENOG4105C3I Nad-dependent epimerase dehydratase HIS92_RS16015 ENOG4105CKK Glycosyl transferase, family 2 HIS92_RS16030 ENOG4105F1A Pyruvate formate-lyase HIS92_RS16050 ENOG4105CI2 imidazolone-5-propionate hydrolase HIS92_RS16055 ENOG4105ECP epimerase HIS92_RS16085 ENOG41067AE Membrane-bound metal-dependent hydrolase HIS92_RS16090 ENOG4105CEN a g-specific adenine glycosylase HIS92_RS16095 ENOG4106BXE HIS92_RS16115 ENOG4105BZ1 (ABC) transporter HIS92_RS16120 ENOG4107NBY Membrane HIS92_RS16125 ENOG4105CBC glutamate synthase HIS92_RS16135 ENOG4108IUW ABC transporter HIS92_RS16155 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HIS92_RS16160 ENOG4105G5W regulator Fur family HIS92_RS16280 ENOG4108JQC penicillin-binding protein 1A HIS92_RS16285 ENOG4108R9S DSBA oxidoreductase HIS92_RS16295 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HIS92_RS16305 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HIS92_RS16310 ENOG4105BZU Histidine kinase HIS92_RS16315 ENOG4105CYN Serine protein kinase HIS92_RS16330 ENOG4105C94 Transporter HIS92_RS16345 ENOG4105DZ6 Band 7 protein HIS92_RS16355 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HIS92_RS16360 ENOG4108V9W transcriptional regulatory protein HIS92_RS16365 ENOG4105D4T Citrate transporter HIS92_RS16390 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HIS92_RS16395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS16400 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HIS92_RS16405 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HIS92_RS16410 ENOG4105BZ7 extracellular solute-binding protein family 1 HIS92_RS16415 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HIS92_RS16420 ENOG4108STX response regulator HIS92_RS16425 ENOG4105US7 Histidine kinase HIS92_RS16450 ENOG4108MRH transcriptional regulatory protein HIS92_RS16460 ENOG4105C6K Malic enzyme HIS92_RS16470 ENOG4108UZ3 Transporter HIS92_RS16475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS16480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS16490 ENOG4105BZU Histidine kinase HIS92_RS16495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS16510 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HIS92_RS16515 ENOG4108JB9 formate dehydrogenase HIS92_RS16535 ENOG4105CUB amino acid HIS92_RS16545 ENOG4105C59 p-type ATPase HIS92_RS16550 ENOG4105DAP Nicotinate phosphoribosyltransferase HIS92_RS16585 ENOG41073R8 VanW family HIS92_RS16590 ENOG4108KGH TRANSCRIPTIONal HIS92_RS16595 ENOG4105D9N nucleoside HIS92_RS16600 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HIS92_RS16605 ENOG4105C37 (CBS) domain HIS92_RS16610 ENOG4108IJ0 Aspartate ammonia-lyase HIS92_RS16615 ENOG4105DAA L-lactate HIS92_RS16630 ENOG4105DUX Transporter HIS92_RS16635 ENOG4108MES Periplasmic binding protein HIS92_RS16640 ENOG4105DQ5 transport system permease protein HIS92_RS16645 ENOG4108IHU transport system permease protein HIS92_RS16650 ENOG4105E0A ABC, transporter HIS92_RS16665 ENOG4105EXW epimerase dehydratase HIS92_RS16675 ENOG4107T89 von Willebrand factor, type A HIS92_RS16680 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HIS92_RS16685 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HIS92_RS16695 ENOG4105BZU Histidine kinase HIS92_RS16700 ENOG4105D5Q Arginine ornithine antiporter HIS92_RS16705 ENOG4107414 GntR family transcriptional regulator HIS92_RS16710 ENOG4105C5Y PTS System HIS92_RS16715 ENOG4105CG3 alpha amylase, catalytic region HIS92_RS16730 ENOG4105E1K spore germination protein HIS92_RS16735 ENOG4105CRN Aminoglycoside phosphotransferase HIS92_RS16745 ENOG4105BZG amino acid carrier protein HIS92_RS16750 ENOG4105CDA abc transporter atp-binding protein HIS92_RS16755 ENOG4105CT1 (ABC) transporter HIS92_RS16760 ENOG4105EAD ABC transporter HIS92_RS16765 ENOG4105DRP amino acid AbC transporter HIS92_RS16770 ENOG4108IQI permease HIS92_RS16785 ENOG4105GFR rna polymerase sigma factor HIS92_RS16795 ENOG4105D29 Helix-turn-helix type 11 domain protein HIS92_RS16800 ENOG4105NAE bifunctional deaminase-reductase domain protein HIS92_RS16805 ENOG4105BZU Histidine kinase HIS92_RS16810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS16830 ENOG4105CHH sulfate transporter HIS92_RS16835 ENOG41068KF Universal stress protein HIS92_RS16845 ENOG4105CXY transporter HIS92_RS16850 ENOG41067TZ transcriptional regulator, MarR family HIS92_RS16855 ENOG4105C0R drug resistance transporter emrb qaca subfamily HIS92_RS16860 ENOG4105ETE Transcriptional regulator (LacI family HIS92_RS16865 ENOG4108RVA ribokinase HIS92_RS16875 ENOG4105C2J ABC transporter HIS92_RS16880 ENOG4105CNN ABC, transporter HIS92_RS16885 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HIS92_RS16930 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HIS92_RS16960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HIS92_RS16965 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HIS92_RS16970 ENOG41069ER domain protein HIS92_RS16975 ENOG4105VZ8 Transcriptional regulator HIS92_RS16980 ENOG4107D63 HIS92_RS16995 ENOG4105DUX Transporter HIS92_RS17015 ENOG4105C85 amino acid HIS92_RS17020 ENOG4105C7N Xanthine uracil vitamin C permease HIS92_RS17035 ENOG4105MA6 gCN5-related N-acetyltransferase HIS92_RS17060 ENOG4105BZ9 Cytochrome C oxidase, subunit I HIS92_RS17065 ENOG4105E2S oxidase) subunit II HIS92_RS17085 ENOG4106CAD Protein of unknown function (DUF3311) HIS92_RS17090 ENOG4105E1V na solute symporter HIS92_RS17105 ENOG4108NHD germination protein HIS92_RS17115 ENOG4105CE1 Ferrous iron transport protein b HIS92_RS17120 ENOG4105CE1 Ferrous iron transport protein b HIS92_RS17125 ENOG4105CE1 Ferrous iron transport protein b HIS92_RS17130 ENOG4105CVA phosphate HIS92_RS17135 ENOG4105C8U phosphate abc transporter HIS92_RS17140 ENOG4105E2Z phosphate ABC transporter (Permease HIS92_RS17270 ENOG41080XQ Signal transduction protein with cbs domains HIS92_RS17290 ENOG4105ETU transcriptional activator (TenA HIS92_RS17300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HIS92_RS17310 ENOG4108VEU Thiamine monophosphate synthase HIS92_RS17315 ENOG41080HI glycine oxidase HIS92_RS17330 ENOG4105D06 uba thif-type nad fad binding protein HIS92_RS17335 ENOG4105DWF phosphomethylpyrimidine kinase HIS92_RS17385 ENOG4108INS Transcriptional regulator HIS92_RS17400 ENOG4105C7N Xanthine uracil vitamin C permease HIS92_RS17410 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HIS92_RS17425 ENOG4105K63 Thioredoxin HIS92_RS17445 ENOG4108B31 Spore germination protein HIS92_RS17465 ENOG4107Y03 Nitroreductase HIS92_RS17470 ENOG4105ED1 spovr family HIS92_RS17490 ENOG4105XTG Pfam:DUF156 HIS92_RS17495 ENOG4105VFE sira family HIS92_RS17500 ENOG4107TPS domain protein HIS92_RS17505 ENOG4105VFE sira family HIS92_RS17510 ENOG4105VFE sira family HIS92_RS17520 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HIS92_RS17525 ENOG41087NI Sulfite exporter TauE/SafE HIS92_RS17535 ENOG4108KGH TRANSCRIPTIONal HIS92_RS17560 ENOG4105EMD TRANSCRIPTIONal HIS92_RS17565 ENOG4105VCP PTS System HIS92_RS17570 ENOG4105VZJ PTS System HIS92_RS17595 ENOG41069ER domain protein HIS92_RS17600 ENOG4107RBB ABC transporter, permease HIS92_RS17605 ENOG4105C19 ABC transporter HIS92_RS17635 ENOG4105WEF catalase HIS92_RS17670 ENOG4107T5V SNARE associated Golgi HIS92_RS17705 ENOG4105CUB amino acid HIS92_RS17710 ENOG4107RWR Sodium hydrogen exchanger HIS92_RS17720 ENOG4106KNT transcriptional regulator HIS92_RS17760 ENOG4108YXU transcriptional regulator AsnC family HIS92_RS17770 ENOG4105UBK short-chain dehydrogenase reductase HIS92_RS17775 ENOG4105W1Y Transcriptional regulator HIS92_RS17820 ENOG4107RKG DJ-1/PfpI family HIS92_RS17825 ENOG4105CH6 catalase HIS92_RS17835 ENOG4105D5Q Arginine ornithine antiporter HIS92_RS17840 ENOG4105C26 Dehydrogenase HIS92_RS17845 ENOG4105BZ1 (ABC) transporter HIS92_RS17850 ENOG4105BZ1 (ABC) transporter HIS92_RS17860 ENOG4105DRP amino acid AbC transporter HIS92_RS17865 ENOG4105CDA abc transporter atp-binding protein HIS92_RS17880 ENOG410839P HIS92_RS17915 ENOG4107FQX Alpha-acetolactate decarboxylase HIS92_RS17940 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HIS92_RS17945 ENOG4105D4P Coproporphyrinogen iii oxidase HIS92_RS17950 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS17960 ENOG4105CHH sulfate transporter HIS92_RS17985 ENOG4105CGU Enoyl-CoA hydratase HIS92_RS18005 ENOG4105DER m42 family HIS92_RS18030 ENOG4105CIF Ornithine Cyclodeaminase HIS92_RS18045 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HIS92_RS18055 ENOG4108JQ7 (ABC) transporter HIS92_RS18085 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HIS92_RS18100 ENOG4105D06 uba thif-type nad fad binding protein HIS92_RS18105 ENOG4107SFI Major Facilitator superfamily HIS92_RS18165 ENOG4105GMB type VI secretion system effector, hcp1 family HIS92_RS18220 ENOG4105CSH Transporter HIS92_RS18230 ENOG4108MRH transcriptional regulatory protein HIS92_RS18275 ENOG4105C4R Atp-dependent dna helicase HIS92_RS18295 ENOG4105CDU Replicative dna helicase HIS92_RS18325 ENOG4105C0R drug resistance transporter emrb qaca subfamily HIS92_RS18410 ENOG4105F6J Alpha beta hydrolase fold HIS92_RS18470 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HIS92_RS18480 ENOG4105F27 Major Facilitator HIS92_RS18485 ENOG4105WAB arsR family transcriptional regulator HIS92_RS18495 ENOG4105CMT Dihydroxyacetone kinase HIS92_RS18505 ENOG4105CMT Dihydroxyacetone kinase HIS92_RS18630 ENOG4105WN5 stage II sporulation protein HIS92_RS18640 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HIS92_RS18650 ENOG4108MJI response regulator HIS92_RS18655 ENOG4105BZU Histidine kinase HIS92_RS18660 ENOG4105BZU Histidine kinase HIS92_RS18700 ENOG4105D7V transposase HIS92_RS18710 ENOG4107QHE Choloylglycine hydrolase HIS92_RS18730 ENOG4107VRP DNA repair exonuclease HIS92_RS18735 ENOG4106D4I domain protein HIS92_RS18750 ENOG410829K Lysine exporter protein (Lyse ygga) HIS92_RS18775 ENOG4108MUZ hydrolase HIS92_RS18800 ENOG4105F0F Oxalate decarboxylase HIS92_RS18805 ENOG41067QW Transcriptional regulator HIS92_RS18810 ENOG4105D7V transposase HIS92_RS18815 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HIS92_RS18830 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HIS92_RS18865 ENOG4105EEM helicase HIS92_RS18870 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HIS92_RS18895 ENOG4105K59 histidine triad (HIT) protein HIS92_RS18930 ENOG410905X membrane-flanked domain protein HIS92_RS18935 ENOG4105CKV Membrane HIS92_RS18975 ENOG410905X membrane-flanked domain protein HIS92_RS18985 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HIS92_RS18990 ENOG4105BZ4 penicillin-binding protein HIS92_RS19000 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HIS92_RS19005 ENOG4105C1Q protoporphyrinogen oxidase HIS92_RS19035 ENOG4105ECB domain protein HIS92_RS19065 ENOG4106AXD HIS92_RS19070 ENOG4108RQ5 Beta-lactamase domain-containing protein HIS92_RS19075 ENOG4105DF9 Lipoate-protein, ligase HIS92_RS19085 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS19145 ENOG4105ENX hydrolase HIS92_RS19150 ENOG4107RN3 metallophosphoesterase HIS92_RS19155 ENOG4107TVP HD domain protein HIS92_RS19165 ENOG4108AEY RNA polymerase sigma factor HIS92_RS19170 ENOG41086D8 Transcriptional regulator HIS92_RS19185 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HIS92_RS19205 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HIS92_RS19210 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS19220 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HIS92_RS19230 ENOG4107QP3 malate synthase g HIS92_RS19265 ENOG4105XVF Competence transcription factor HIS92_RS19330 ENOG4105ERH Fumarylacetoacetate hydrolase HIS92_RS19340 ENOG4105C8Y Acetylornithine aminotransferase HIS92_RS19355 ENOG4105CAQ asparagine synthetase HIS92_RS19360 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HIS92_RS19365 ENOG4105CH6 catalase HIS92_RS19370 ENOG4105BZU Histidine kinase HIS92_RS19390 ENOG4105QNR S1 RNA binding domain protein HIS92_RS19395 ENOG4105CNA YD repeat protein HIS92_RS19440 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HIS92_RS19450 ENOG4107AYK membrAne HIS92_RS19455 ENOG41073B9 HIS92_RS19465 ENOG4108KP7 hydrolase HIS92_RS19475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HIS92_RS19500 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HIS92_RS19505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HIS92_RS19520 ENOG4105C31 Tryptophanyl-tRNA synthetase HIS92_RS19535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HIS92_RS19540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HIS92_RS19550 ENOG4108JQ7 (ABC) transporter HIS92_RS19555 ENOG4105UQX Mate efflux family protein HIS92_RS19575 ENOG4108ZCF integral membrane protein HIS92_RS19585 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HIS92_RS19595 ENOG4105DPN Oligoendopeptidase f HIS92_RS19610 ENOG4108Z18 K06886 hemoglobin HIS92_RS19615 ENOG4105MIX Adenylate cyclase HIS92_RS19630 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HIS92_RS19635 ENOG4105EMS pseudouridine synthase HIS92_RS19655 ENOG4105K64 Glycosyl transferase, family 2 HIS92_RS19695 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HIS92_RS19700 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HIS92_RS19710 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HIS92_RS19785 ENOG4105CK7 Sodium proline symporter HIS92_RS19795 ENOG4105DDQ anthranilate synthase HIS92_RS19890 ENOG4105C7S Dehydrogenase HIS92_RS19900 ENOG4105VZ8 Transcriptional regulator HIS92_RS19930 ENOG4108IUX (ABC) transporter HIS92_RS19935 ENOG4105RHA ABC transporter, permease HIS92_RS19960 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HIS92_RS19970 ENOG4105DZ1 carboxypeptidase HIS92_RS19975 ENOG4105VFR signal peptidase HIS92_RS20010 ENOG4105C26 Dehydrogenase HIS92_RS20015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS20020 ENOG4105F38 ABC transporter, permease HIS92_RS20025 ENOG4105D38 putrescine abc transporter HIS92_RS20030 ENOG4108HM4 ABC transporter HIS92_RS20035 ENOG410841Q phosphoesterase PA-phosphatase related protein HIS92_RS20040 ENOG4105EYF MMPL domain protein HIS92_RS20050 ENOG4108YBP pseudouridine synthase HIS92_RS20060 ENOG4105K4I Scp-like extracellular HIS92_RS20065 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HIS92_RS20070 ENOG4105CQB FAD linked oxidase domain protein HIS92_RS20085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS20090 ENOG4105BZU Histidine kinase HIS92_RS20095 ENOG4105JXH GntR family transcriptional regulator HIS92_RS20115 ENOG4106A3R peptidase HIS92_RS20125 ENOG4108QTI )-transporter HIS92_RS20130 ENOG4107TS3 membrane protein, TerC HIS92_RS20135 ENOG4105CZN Potassium uptake protein HIS92_RS20140 ENOG410681C small acid-soluble spore protein HIS92_RS20145 ENOG4108Z7G MaoC domain protein dehydratase HIS92_RS20165 ENOG4105CHR reductase HIS92_RS20195 ENOG4105C4Y ABC transporter HIS92_RS20200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HIS92_RS20205 ENOG4107RCV ABC transporter, permease HIS92_RS20225 ENOG4105E98 transcriptional regulator DeoR family HIS92_RS20235 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HIS92_RS20245 ENOG4105PXI polysaccharide deacetylase HIS92_RS20255 ENOG4105BZU Histidine kinase HIS92_RS20260 ENOG41090MY MarR family Transcriptional regulator HIS92_RS20270 ENOG4106DF1 HIS92_RS20275 ENOG4105BZU Histidine kinase HIS92_RS20285 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HIS92_RS20290 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HIS92_RS20330 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HIS92_RS20335 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HIS92_RS20340 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HIS92_RS20345 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS20350 ENOG4105CZV ABC transporter HIS92_RS20360 ENOG4105CJ1 ABC, transporter HIS92_RS20400 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HIS92_RS20405 ENOG4105EA8 2-Nitropropane dioxygenase HIS92_RS20410 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HIS92_RS20420 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HIS92_RS20445 ENOG4105NQC Flavodoxin HIS92_RS20485 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HIS92_RS20515 ENOG4105CZN Potassium uptake protein HIS92_RS20520 ENOG41063Y9 HIS92_RS20525 ENOG4105KBJ sporulation protein ytfj HIS92_RS20545 ENOG4105CM2 brancheD-chain amino acid aminotransferase HIS92_RS20550 ENOG4105C7K acetolactate synthase HIS92_RS20555 ENOG4108ZP8 Acetolactate synthase small subunit HIS92_RS20560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HIS92_RS20595 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HIS92_RS20630 ENOG4107RVV histidinol phosphate phosphatase, hisj family HIS92_RS20645 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HIS92_RS20650 ENOG4105E0M Sulfatase HIS92_RS20660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HIS92_RS20680 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HIS92_RS20685 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HIS92_RS20695 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HIS92_RS20700 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HIS92_RS20705 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HIS92_RS20710 ENOG4105C8J )-transporter HIS92_RS20735 ENOG4105DFD Na H antiporter HIS92_RS20755 ENOG4105ENE Histidine kinase HIS92_RS20760 ENOG4105WH1 Two component transcriptional regulator luxr family HIS92_RS20780 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HIS92_RS20805 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HIS92_RS20825 ENOG4105CJ3 phosphate transporter HIS92_RS20830 ENOG4107GRR phosphate transport regulator HIS92_RS20835 ENOG4105BZ4 penicillin-binding protein HIS92_RS20850 ENOG4105BZU Histidine kinase HIS92_RS20855 ENOG4105I3N Conserved Protein HIS92_RS20870 ENOG4105BZU Histidine kinase HIS92_RS20900 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HIS92_RS20905 ENOG4105DZ1 carboxypeptidase HIS92_RS20910 ENOG4108JIC nucleoside recognition domain protein HIS92_RS20920 ENOG4105FE9 pseudouridine synthase HIS92_RS20925 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HIS92_RS20930 ENOG4107TWT Cytochrome c biogenesis protein HIS92_RS20935 ENOG4105CRE cytochrome C HIS92_RS20940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HIS92_RS20945 ENOG4105BZU Histidine kinase HIS92_RS20950 ENOG4108WBT adenosyltransferase HIS92_RS20955 ENOG41063SB peptidase HIS92_RS20965 ENOG4108SAX Membrane HIS92_RS20980 ENOG4105C9U ATP-dependent DNA helicase RecQ HIS92_RS20985 ENOG4105I7S Abortive infection protein HIS92_RS20995 ENOG4107RGJ metallophosphoesterase HIS92_RS21000 ENOG4108XDN Transcriptional regulator HIS92_RS21005 ENOG4108S6Z Negative regulator of genetic competence HIS92_RS21030 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HIS92_RS21035 ENOG4107RB3 L-asparaginase HIS92_RS21070 ENOG4105S2F HIS92_RS21075 ENOG41065D1 HIS92_RS21105 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HIS92_RS21120 ENOG4105XXQ heptaprenyl diphosphate synthase component I HIS92_RS21130 ENOG4105EAH synthase HIS92_RS21135 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HIS92_RS21140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HIS92_RS21155 ENOG41068YB TPR repeat-containing protein HIS92_RS21170 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HIS92_RS21175 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HIS92_RS21210 ENOG4108JYZ YitT family HIS92_RS21215 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HIS92_RS21230 ENOG4105FJR Lmbe family HIS92_RS21235 ENOG4105CPK Glycosyl transferase (Group 1 HIS92_RS21270 ENOG4105DVT helicase HIS92_RS21275 ENOG4105YAC HIS92_RS21295 ENOG4105CSM endonuclease III HIS92_RS21305 ENOG4105BZ4 penicillin-binding protein HIS92_RS21360 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HIS92_RS21370 ENOG4105DVT helicase HIS92_RS21375 ENOG4105CTD carboxy-peptidase HIS92_RS21390 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HIS92_RS21400 ENOG4105C2W permease HIS92_RS21405 ENOG4105DHF Membrane HIS92_RS21415 ENOG410890F Dynamin family HIS92_RS21425 ENOG4108W0I acetyltransferase HIS92_RS21435 ENOG4105KHC sulfurtransferase HIS92_RS21460 ENOG4106032 Glutathionylspermidine synthase HIS92_RS21490 ENOG4105HTX biosynthesis protein HIS92_RS21520 ENOG4105CPK Glycosyl transferase (Group 1 HIS92_RS21535 ENOG4108SZE gCN5-related N-acetyltransferase HIS92_RS21555 ENOG41081VK Ribonuclease HIS92_RS21620 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HIS92_RS21630 ENOG4107RWR Sodium hydrogen exchanger HIS92_RS21640 ENOG4108Z5V transcriptional regulator, merr family HIS92_RS21650 ENOG4105H67 Protein of unknown function (DUF421) HIS92_RS21655 ENOG41080C8 DUF218 domain HIS92_RS21695 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HIS92_RS21705 ENOG4107R0U MotA TolQ exbB proton channel HIS92_RS21710 ENOG4105ER2 Ompa motb domain protein HIS92_RS21715 ENOG4107YTP response regulator receiver protein HIS92_RS21720 ENOG4105CBS Chea signal transduction histidine kinase HIS92_RS21725 ENOG4105DD5 Flagellar motor switch protein HIS92_RS21740 ENOG4105BZU Histidine kinase HIS92_RS21760 ENOG4105E1Q flagellar hook-associated protein HIS92_RS21765 ENOG4105DTJ flagellar hook-associated protein HIS92_RS21785 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HIS92_RS21790 ENOG4108ZC9 flagellar basal-body rod protein flgc HIS92_RS21800 ENOG4107U2N Flagellar M-ring protein HIS92_RS21805 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HIS92_RS21835 ENOG4105BZE flagellar hook protein, FlgE HIS92_RS21850 ENOG4107R88 Chemotaxis protein (CheV) HIS92_RS21870 ENOG4105I03 Flagellin HIS92_RS21875 ENOG4105E4C Lytic transglycosylase catalytic HIS92_RS21885 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HIS92_RS21890 ENOG4105DD5 Flagellar motor switch protein HIS92_RS21900 ENOG4105CN7 Flagellar biosynthetic protein FliP HIS92_RS21905 ENOG4105VS8 Flagellar biosynthetic protein fliq HIS92_RS21915 ENOG4105D00 flagellar biosynthetic protein flhB HIS92_RS21920 ENOG4105D7B Flagellar biosynthesis protein flha HIS92_RS21925 ENOG4105FZW flagellar biosynthesis regulator FlhF HIS92_RS21930 ENOG4105KTQ flagellar basal-body rod protein HIS92_RS21940 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HIS92_RS21970 ENOG4105KAC Antibiotic biosynthesis monooxygenase HIS92_RS21975 ENOG4107QZ7 Cellulose synthase catalytic subunit HIS92_RS22015 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HIS92_RS22020 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HIS92_RS22055 ENOG4105CVJ phosphoglycerate mutase HIS92_RS22065 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HIS92_RS22075 ENOG4105K56 Transcriptional regulator HIS92_RS22085 ENOG4105CAQ asparagine synthetase HIS92_RS22105 ENOG4105PGM cation diffusion facilitator family transporter HIS92_RS22125 ENOG4105CKI cobalamin synthesis protein HIS92_RS22130 ENOG4108PJD permease HIS92_RS22145 ENOG4105DFD Na H antiporter HIS92_RS22150 ENOG4105VUF Transcriptional regulator HIS92_RS22160 ENOG4105C9Q fumarate hydratase class II HIS92_RS22180 ENOG4107QJQ Mate efflux family protein HIS92_RS22185 ENOG4105EC3 peptidase S51, dipeptidase E HIS92_RS22205 ENOG4107QIV Cytochrome c biogenesis protein HIS92_RS22210 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HIS92_RS22225 ENOG4107JM4 Tetratricopeptide repeat HIS92_RS22245 ENOG4106BRA Membrane HIS92_RS22280 ENOG4105CJ1 ABC, transporter HIS92_RS22300 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HIS92_RS22310 ENOG4108IJ0 Aspartate ammonia-lyase HIS92_RS22315 ENOG4105C6K Malic enzyme HIS92_RS22365 ENOG4105FVX HIS92_RS22370 ENOG4105E09 nadh pyrophosphatase HIS92_RS22385 ENOG4105CSR polyphosphate kinase 2 HIS92_RS22390 ENOG4105U3E Transcriptional regulator HIS92_RS22400 ENOG4105DXI Major Facilitator superfamily HIS92_RS22410 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HIS92_RS22415 ENOG4105EU0 Major facilitator Superfamily HIS92_RS22420 ENOG4105C6T cysteine synthase HIS92_RS22440 ENOG4105C8J )-transporter HIS92_RS22450 ENOG4105X5K response regulator receiver protein HIS92_RS22455 ENOG4105H67 Protein of unknown function (DUF421) HIS92_RS22475 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HIS92_RS22480 ENOG4105CHR reductase HIS92_RS22485 ENOG4105CM2 brancheD-chain amino acid aminotransferase HIS92_RS22490 ENOG4105C7K acetolactate synthase HIS92_RS22500 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HIS92_RS22510 ENOG4105C7B Threonine dehydratase HIS92_RS22535 ENOG4105C6X Major Facilitator HIS92_RS22540 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HIS92_RS22555 ENOG4105DY9 regulatoR HIS92_RS22560 ENOG4105CYC Transferase HIS92_RS22585 ENOG41068WN HIS92_RS22605 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HIS92_RS22620 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HIS92_RS22625 ENOG4105C0X amino acid HIS92_RS22660 ENOG410849A acetyltransferase, (GNAT) family HIS92_RS22665 ENOG4105K8R UPF0145 protein HIS92_RS22680 ENOG4107RHR regulatoR HIS92_RS22690 ENOG4105D9N nucleoside HIS92_RS22695 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HIS92_RS22700 ENOG4105KG3 cytidine deaminase HIS92_RS22745 ENOG4107RAQ aminopeptidase HIS92_RS22755 ENOG4107R16 Multicopper oxidase HIS92_RS22795 ENOG4108T5E Copper resistance protein HIS92_RS22800 ENOG4105KTB nuclear export factor GLE1 HIS92_RS22805 ENOG4107RT3 EamA-like transporter family HIS92_RS22810 ENOG4105GZI Transcriptional regulator HIS92_RS22815 ENOG4108Z40 Transcriptional regulator HIS92_RS22820 ENOG4107ZXU DSBA oxidoreductase HIS92_RS22825 ENOG4108TVJ Nitroreductase HIS92_RS22830 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HIS92_RS22835 ENOG4106F5Q Membrane HIS92_RS22840 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HIS92_RS22850 ENOG4105CKI cobalamin synthesis protein HIS92_RS22860 ENOG4105C0Z ABC transporter HIS92_RS22865 ENOG4108IV0 ABC, transporter HIS92_RS22870 ENOG4105C32 Amino acid ABC transporter (Permease) HIS92_RS22880 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HIS92_RS22910 ENOG4105C4M (Ubiquinol oxidase) subunit I HIS92_RS22915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HIS92_RS22920 ENOG4108JJ9 ABC, transporter HIS92_RS22925 ENOG4108JJ8 (ABC) transporter HIS92_RS22935 ENOG4105K64 Glycosyl transferase, family 2 HIS92_RS22945 ENOG4108UT6 Transferase hexapeptide repeat containing protein HIS92_RS23000 ENOG4105BZ1 (ABC) transporter HIS92_RS23005 ENOG4105EFI regulatoR HIS92_RS23010 ENOG4105BZU Histidine kinase HIS92_RS23030 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HIS92_RS23055 ENOG4105D6E homoserine dehydrogenase HIS92_RS23080 ENOG4108KGH TRANSCRIPTIONal HIS92_RS23095 ENOG4105KT7 mgtC SapB transporter HIS92_RS23100 ENOG4105VRR gCN5-related N-acetyltransferase HIS92_RS23110 ENOG4105DUU IucA IucC family protein HIS92_RS23115 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS23130 ENOG4108WBH protein TIM barrel HIS92_RS23135 ENOG4105YWU small acid-soluble spore protein HIS92_RS23145 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HIS92_RS23150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS23200 ENOG4105KRN Transcriptional regulator, abrb family HIS92_RS23210 ENOG4105YVS arsR family transcriptional regulator HIS92_RS23215 ENOG4105CPC Aldo Keto reductase HIS92_RS23245 ENOG4105C8Q Methyl-accepting chemotaxis HIS92_RS23260 ENOG4108K88 Membrane HIS92_RS23265 ENOG4108WPJ Ferritin-like domain HIS92_RS23280 ENOG4105DEN Luciferase family HIS92_RS23295 ENOG4105VMI -acetyltransferase HIS92_RS23300 ENOG4107QM2 Aldo Keto reductase HIS92_RS23305 ENOG4105CKI cobalamin synthesis protein HIS92_RS23315 ENOG4105DSE periplasmic solute binding protein HIS92_RS23325 ENOG4105K4T epimerase HIS92_RS23335 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HIS92_RS23360 ENOG4105CVJ phosphoglycerate mutase HIS92_RS23380 ENOG4107T5V SNARE associated Golgi HIS92_RS23395 ENOG4108PJD permease HIS92_RS23405 ENOG4108S4H thioesterase Superfamily protein HIS92_RS23415 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HIS92_RS23435 ENOG4105SXS Protein of unknown function (DUF456) HIS92_RS23440 ENOG4105C37 (CBS) domain HIS92_RS23470 ENOG4108Z7R Chaperone CsaA HIS92_RS23490 ENOG4108ZRV stage ii sporulation protein p HIS92_RS23500 ENOG4108VXD carboxy-peptidase HIS92_RS23530 ENOG4108ZRV stage ii sporulation protein p HIS92_RS23540 ENOG4108X4Q Hydrolase HIS92_RS23545 ENOG41082F9 transcriptional regulator HIS92_RS23550 ENOG4105D94 Major Facilitator Superfamily HIS92_RS23560 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HIS92_RS23580 ENOG41087PP glycosyltransferase MGT family HIS92_RS23585 ENOG4108JYZ YitT family HIS92_RS23590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HIS92_RS23620 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HIS92_RS23775 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HIS92_RS23785 ENOG4105KBJ sporulation protein ytfj HIS92_RS23810 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HIS92_RS23830 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HIS92_RS23835 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HIS92_RS23845 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HIS92_RS23850 ENOG4105EMN RNA polymerase sigma factor HIS92_RS23860 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HIS92_RS23870 ENOG4105CNW domain protein HIS92_RS23880 ENOG4108V06 Glutathione peroxidase HIS92_RS23895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HIS92_RS23905 ENOG4108IUE nitrate reductase beta subunit HIS92_RS23910 ENOG4105R3A Nitrate reductase HIS92_RS23920 ENOG4107V6Q Cyclic nucleotide-binding domain HIS92_RS23925 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HIS92_RS23930 ENOG4105D06 uba thif-type nad fad binding protein HIS92_RS23935 ENOG4105CVM Molybdenum cofactor synthesis domain protein HIS92_RS23940 ENOG4108ZAF Molybdopterin HIS92_RS23965 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HIS92_RS23970 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HIS92_RS23975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HIS92_RS23980 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HIS92_RS23985 ENOG4108IFG nitrite reductase, (NAD(P)H) HIS92_RS23990 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HIS92_RS24025 ENOG4105MCT stage V sporulation protein S HIS92_RS24065 ENOG4105C5H ABC transporter HIS92_RS24080 ENOG4108UUM single-stranded DNA-binding protein HIS92_RS24105 ENOG4107YX5 Pfam:DUF548 HIS92_RS24110 ENOG4105C75 arginyL-tRNA synthetase HIS92_RS24135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HIS92_RS24150 ENOG4105C5S asparaginyl-tRNA synthetase HIS92_RS24155 ENOG4105C8J )-transporter HIS92_RS24160 ENOG4108EF6 Proline imino-peptidase HIS92_RS24175 ENOG4107XGZ Hydrolase HIS92_RS24180 ENOG4105CY2 Citrate transporter HIS92_RS24200 ENOG4105KD7 acetyltransferase HIS92_RS24210 ENOG4105VMP Transcriptional regulator HIS92_RS24215 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HIS92_RS24240 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HIS92_RS24270 ENOG4107RVG penicillin-binding protein HIS92_RS24280 ENOG4105E9Q Acyl-transferase HIS92_RS24285 ENOG4108UT2 hemolysin iii HIS92_RS24295 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HIS92_RS24305 ENOG4108RCR degv family HIS92_RS24315 ENOG4108KF3 Electron transport protein SCO1 SenC HIS92_RS24320 ENOG4107Y70 Heat shock protein HIS92_RS24325 ENOG4105CAQ asparagine synthetase HIS92_RS24340 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HIS92_RS24345 ENOG4108MES Periplasmic binding protein HIS92_RS24350 ENOG4105F0I Aminotransferase HIS92_RS24375 ENOG4105D8X mechanosensitive ion channel HIS92_RS24380 ENOG4105BZU Histidine kinase HIS92_RS24385 ENOG4105WH1 Two component transcriptional regulator luxr family HIS92_RS24390 ENOG4106KNT transcriptional regulator HIS92_RS24395 ENOG4107ZY0 Phenazine biosynthesis-like protein HIS92_RS24415 ENOG4105CMG Carbohydrate kinase HIS92_RS24420 ENOG4105C6Z Gluconate HIS92_RS24430 ENOG4108YV3 Protein of unknown function (DUF2711) HIS92_RS24460 ENOG4108IJ8 ABC transporter HIS92_RS24465 ENOG4105E90 ABC transporter HIS92_RS24500 ENOG4105C37 (CBS) domain HIS92_RS24525 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HIS92_RS24540 ENOG4107S4Y M20 DapE family protein YgeY HIS92_RS24545 ENOG4108TSC N-acetyltransferase HIS92_RS24550 ENOG4108JUB Transcriptional regulator HIS92_RS24555 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HIS92_RS24600 ENOG410841Q phosphoesterase PA-phosphatase related protein HIS92_RS24610 ENOG4105SZ6 Thioredoxin HIS92_RS24650 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HIS92_RS24705 ENOG4105BZ4 penicillin-binding protein HIS92_RS24715 ENOG4105CZM Major Facilitator HIS92_RS24720 ENOG4105W8X HesB YadR YfhF-family protein HIS92_RS24730 ENOG4105DXD 2-methylcitrate dehydratase HIS92_RS24735 ENOG4105CR4 methylisocitrate lyase HIS92_RS24740 ENOG4105C1G acyl-Coa dehydrogenase HIS92_RS24745 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HIS92_RS24755 ENOG4105N14 lysine exporter protein LysE YggA HIS92_RS24760 ENOG4105E39 Enoyl-CoA hydratase HIS92_RS24775 ENOG4107RFY SbcCD D subunit HIS92_RS24780 ENOG4105EYH Exonuclease HIS92_RS24800 ENOG4105FCD Major Facilitator HIS92_RS24805 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HIS92_RS24810 ENOG4105E4F Isochorismate synthase HIS92_RS24815 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HIS92_RS24820 ENOG4105WQI isochorismatase HIS92_RS24825 ENOG4105CEY Amp-dependent synthetase and ligase HIS92_RS24830 ENOG4105WQT MbtH domain protein HIS92_RS24835 ENOG4105C0R drug resistance transporter emrb qaca subfamily HIS92_RS24850 ENOG4105K70 DNA-binding protein HIS92_RS24870 ENOG4105BZG amino acid carrier protein HIS92_RS24890 ENOG4105FE9 pseudouridine synthase HIS92_RS24895 ENOG4105C22 threonyL-tRNA synthetase HIS92_RS24900 ENOG4105C19 ABC transporter HIS92_RS24960 ENOG4105C0B DNA polymerase III (alpha subunit) HIS92_RS24970 ENOG4105C0B DNA polymerase III (alpha subunit) HIS92_RS24985 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HIS92_RS24995 ENOG4105EKQ RNA-directed DNA polymerase HIS92_RS25000 ENOG4105GJD protein, conserved in bacteria HIS92_RS25040 ENOG4107JM4 Tetratricopeptide repeat HIS92_RS25100 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HIS92_RS25215 ENOG4108UUM single-stranded DNA-binding protein HIS92_RS25225 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HIS92_RS25260 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HIS92_RS25265 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HIS92_RS25285 ENOG4105C4R Atp-dependent dna helicase HIS92_RS25290 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HIS92_RS25295 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HIS92_RS25335 ENOG4105K6T rare lipoprotein A HIS92_RS25340 ENOG4105C0D helicase HIS92_RS25355 ENOG4105BZU Histidine kinase HIS92_RS25360 ENOG4105GR3 Histidine kinase HIS92_RS25380 ENOG4105ZMH deoxynucleoside kinase HIS92_RS25565 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HIS92_RS25590 ENOG4106FN3 tellurium resistance protein HIS92_RS25595 ENOG4106FN3 tellurium resistance protein HIS92_RS25605 ENOG4107TS3 membrane protein, TerC HIS92_RS25615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HIS92_RS25625 ENOG4105D9N nucleoside HIS92_RS25650 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HIS92_RS25655 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HIS92_RS25660 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HIS92_RS25665 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HIS92_RS25705 ENOG4108IBT Inherit from COG: transposase HIS92_RS26165 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HIS92_RS26195 ENOG4105K4W Could be involved in septation (By similarity) HIS92_RS26220 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)