locus-tag	class	description
HD73_RS00010	COG0592	DNA-directed DNA polymerase activity
HD73_RS00015	COG2501	S4 domain
HD73_RS00025	COG0187	DNA topoisomerase II activity
HD73_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD73_RS00065	COG0517	IMP dehydrogenase activity
HD73_RS00065	COG0516	GMP reductase activity
HD73_RS00070	COG1686	Belongs to the peptidase S11 family
HD73_RS00100	COG1428	Deoxynucleoside kinase
HD73_RS00105	COG1428	Deoxynucleoside kinase
HD73_RS00110	COG1335	isochorismatase
HD73_RS00120	COG0590	tRNA wobble adenosine to inosine editing
HD73_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HD73_RS00180	COG1982	Orn Lys Arg decarboxylase major
HD73_RS00190	COG0470	DNA polymerase III
HD73_RS00195	COG1774	PSP1 C-terminal conserved region
HD73_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HD73_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HD73_RS00220	COG2002	toxin-antitoxin pair type II binding
HD73_RS00230	COG0084	hydrolase, TatD family'
HD73_RS00250	COG4466	Protein conserved in bacteria
HD73_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HD73_RS00270	COG0251	oxidation-reduction process
HD73_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HD73_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD73_RS00305	COG2002	toxin-antitoxin pair type II binding
HD73_RS00310	COG2244	polysaccharide biosynthetic process
HD73_RS00315	COG3956	TIGRFAM MazG family protein
HD73_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HD73_RS00340	COG1098	S1 RNA binding domain
HD73_RS00355	COG2208	phosphoserine phosphatase activity
HD73_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HD73_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HD73_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HD73_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HD73_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
HD73_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HD73_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HD73_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HD73_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HD73_RS00420	COG1396	sequence-specific DNA binding
HD73_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HD73_RS00455	COG3880	PFAM UvrB UvrC protein
HD73_RS00465	COG0542	response to heat
HD73_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HD73_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
HD73_RS00500	COG1045	serine acetyltransferase
HD73_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HD73_RS00520	COG3688	RNA-binding protein containing a PIN domain
HD73_RS00535	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HD73_RS00540	COG0250	Participates in transcription elongation, termination and antitermination
HD73_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HD73_RS00565	COG2813	Specifically methylates the guanine in position
HD73_RS00580	COG1358	cellular component organization or biogenesis
HD73_RS00585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HD73_RS00650	COG0255	Belongs to the universal ribosomal protein uL29 family
HD73_RS00710	COG0201	protein transport
HD73_RS00720	COG0024	Methionine aminopeptidase
HD73_RS00730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HD73_RS00765	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HD73_RS00790	COG0860	N-Acetylmuramoyl-L-alanine amidase
HD73_RS00795	COG0489	protein tyrosine kinase activity
HD73_RS00805	COG2194	sulfuric ester hydrolase activity
HD73_RS00810	COG0726	polysaccharide deacetylase
HD73_RS00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HD73_RS00895	COG4856	YbbR-like protein
HD73_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS00935	COG2011	ABC-type metal ion transport system permease component
HD73_RS00940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HD73_RS00945	COG1464	Belongs to the NlpA lipoprotein family
HD73_RS00950	COG0604	alcohol dehydrogenase
HD73_RS00960	COG0277	FAD linked oxidase domain protein
HD73_RS00965	COG2271	Major facilitator Superfamily
HD73_RS00975	COG2814	Major facilitator Superfamily
HD73_RS00990	COG2207	Transcriptional regulator
HD73_RS01005	COG4166	transmembrane transport
HD73_RS01010	COG4166	transmembrane transport
HD73_RS01015	COG0656	L-ascorbic acid biosynthetic process
HD73_RS01030	COG4149	molybdate abc transporter
HD73_RS01035	COG0725	ABC transporter, periplasmic molybdate-binding protein
HD73_RS01040	COG1910	domain protein
HD73_RS01060	COG0697	spore germination
HD73_RS01075	COG0204	Acyl-transferase
HD73_RS01085	COG1609	Transcriptional regulator
HD73_RS01095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS01105	COG2963	transposase activity
HD73_RS01110	COG2801	Transposase and inactivated derivatives
HD73_RS01125	COG5298	Protein conserved in bacteria
HD73_RS01150	COG0488	(ABC) transporter
HD73_RS01160	COG0747	negative chemotaxis
HD73_RS01180	COG3344	reverse transcriptase
HD73_RS01190	COG0601	transmembrane transport
HD73_RS01195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HD73_RS01200	COG0444	Belongs to the ABC transporter superfamily
HD73_RS01205	COG4608	Belongs to the ABC transporter superfamily
HD73_RS01210	COG2801	Transposase and inactivated derivatives
HD73_RS01220	COG0561	phosphatase activity
HD73_RS01245	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HD73_RS01250	COG0179	Fumarylacetoacetate (FAA) hydrolase
HD73_RS01260	COG0531	amino acid
HD73_RS01265	COG2814	Major facilitator Superfamily
HD73_RS01275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HD73_RS01285	COG4294	response to UV
HD73_RS01290	COG0705	Rhomboid family
HD73_RS01300	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HD73_RS01305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HD73_RS01310	COG0864	Transcriptional regulator
HD73_RS01315	COG2337	Toxic component of a toxin-antitoxin (TA) module
HD73_RS01320	COG2183	response to ionizing radiation
HD73_RS01420	COG0802	atpase or kinase
HD73_RS01425	COG1214	PFAM Peptidase M22, glycoprotease
HD73_RS01430	COG0456	acetyltransferase
HD73_RS01440	COG0488	(ABC) transporter
HD73_RS01455	COG1266	CAAX protease self-immunity
HD73_RS01475	COG0582	viral genome integration into host DNA
HD73_RS01610	COG0582	viral genome integration into host DNA
HD73_RS01710	COG4824	toxin secretion phage lysis holin
HD73_RS01745	COG2252	PERMEase
HD73_RS01755	COG5002	protein histidine kinase activity
HD73_RS01790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HD73_RS01830	COG2205	protein histidine kinase activity
HD73_RS01835	COG0745	RESPONSE REGULATOR receiver
HD73_RS01895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HD73_RS01905	COG1216	Glycosyl transferase, family 2
HD73_RS01905	COG0463	Glycosyl transferase, family 2
HD73_RS01940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HD73_RS01945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HD73_RS01950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HD73_RS01960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HD73_RS01975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HD73_RS01985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HD73_RS01995	COG0151	Belongs to the GarS family
HD73_RS02025	COG0210	DNA helicase
HD73_RS02035	COG4851	CamS sex pheromone cAM373 precursor
HD73_RS02050	COG1335	isochorismatase
HD73_RS02060	COG2011	ABC-type metal ion transport system permease component
HD73_RS02065	COG1464	Belongs to the NlpA lipoprotein family
HD73_RS02080	COG0003	Pfam Anion-transporting ATPase
HD73_RS02085	COG1846	Transcriptional regulator
HD73_RS02090	COG4682	membrane
HD73_RS02110	COG1597	lipid kinase activity
HD73_RS02120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HD73_RS02130	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS02135	COG2076	Multidrug Resistance protein
HD73_RS02145	COG2309	aminopeptidase activity
HD73_RS02160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS02170	COG0582	viral genome integration into host DNA
HD73_RS02215	COG1484	DNA-dependent DNA replication
HD73_RS02225	COG2002	toxin-antitoxin pair type II binding
HD73_RS02310	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS02315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS02320	COG0582	viral genome integration into host DNA
HD73_RS02360	COG4626	Terminase
HD73_RS02360	COG1802	Transcriptional regulator
HD73_RS02370	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS02375	COG0740	serine-type endopeptidase activity
HD73_RS02460	COG0730	response to heat
HD73_RS02485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HD73_RS02490	COG4807	Protein conserved in bacteria
HD73_RS02520	COG1473	amidohydrolase
HD73_RS02535	COG0450	alkyl hydroperoxide reductase
HD73_RS02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS02560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS02565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS02575	COG0492	ferredoxin-NADP+ reductase activity
HD73_RS02590	COG0166	Belongs to the GPI family
HD73_RS02615	COG5002	protein histidine kinase activity
HD73_RS02635	COG3541	Predicted nucleotidyltransferase
HD73_RS02640	COG2814	Major facilitator Superfamily
HD73_RS02645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD73_RS02645	COG0723	plastoquinol--plastocyanin reductase activity
HD73_RS02655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD73_RS02655	COG0723	plastoquinol--plastocyanin reductase activity
HD73_RS02665	COG0765	amino acid transport
HD73_RS02670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD73_RS02680	COG0840	transmembrane signaling receptor activity
HD73_RS02705	COG0549	Belongs to the carbamate kinase family
HD73_RS02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HD73_RS02735	COG0366	Alpha amylase catalytic
HD73_RS02740	COG1263	PTS System
HD73_RS02740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD73_RS02740	COG2190	(PTS) system
HD73_RS02770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HD73_RS02790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HD73_RS02800	COG1116	anion transmembrane transporter activity
HD73_RS02845	COG2270	Major facilitator Superfamily
HD73_RS02875	COG2310	stress, protein
HD73_RS02880	COG2310	stress, protein
HD73_RS02885	COG2310	stress, protein
HD73_RS02890	COG0861	Integral membrane protein TerC family
HD73_RS02900	COG3853	Toxic anion resistance protein (TelA)
HD73_RS02915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HD73_RS02925	COG1295	ribonuclease BN
HD73_RS02930	COG2217	Heavy metal translocating P-type atpase
HD73_RS02955	COG0586	Pfam SNARE associated Golgi protein
HD73_RS02970	COG3871	stress protein (general stress protein 26)
HD73_RS02975	COG0387	Pfam Sodium calcium exchanger
HD73_RS02985	COG0535	radical SAM domain protein
HD73_RS03005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HD73_RS03010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HD73_RS03025	COG3829	transcription factor binding
HD73_RS03035	COG0833	amino acid
HD73_RS03040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HD73_RS03075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD73_RS03075	COG1263	PTS System
HD73_RS03080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HD73_RS03095	COG0463	Glycosyl transferase, family 2
HD73_RS03105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HD73_RS03105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HD73_RS03125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HD73_RS03145	COG1228	amidohydrolase
HD73_RS03150	COG1090	epimerase
HD73_RS03180	COG1988	membrane-bound metal-dependent
HD73_RS03185	COG1194	a g-specific adenine glycosylase
HD73_RS03210	COG1132	(ABC) transporter
HD73_RS03215	COG4129	membrane
HD73_RS03220	COG0067	glutamate synthase
HD73_RS03220	COG0069	glutamate synthase activity
HD73_RS03220	COG0070	glutamate synthase
HD73_RS03230	COG4555	ABC transporter
HD73_RS03250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HD73_RS03255	COG0735	belongs to the Fur family
HD73_RS03375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HD73_RS03400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HD73_RS03405	COG5001	Diguanylate cyclase
HD73_RS03405	COG1716	ATPase activity
HD73_RS03415	COG2766	serine protein kinase
HD73_RS03435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HD73_RS03445	COG1585	Membrane protein implicated in regulation of membrane protease activity
HD73_RS03450	COG2268	Band 7 protein
HD73_RS03460	COG3290	protein histidine kinase activity
HD73_RS03465	COG4565	transcriptional regulatory protein
HD73_RS03470	COG2851	Citrate transporter
HD73_RS03495	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HD73_RS03500	COG3842	ATPase activity
HD73_RS03505	COG1175	transmembrane transport
HD73_RS03510	COG0395	ABC-type sugar transport system, permease component
HD73_RS03520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HD73_RS03525	COG0745	RESPONSE REGULATOR receiver
HD73_RS03530	COG5002	protein histidine kinase activity
HD73_RS03530	COG3850	Histidine kinase
HD73_RS03540	COG4990	cell redox homeostasis
HD73_RS03550	COG3290	protein histidine kinase activity
HD73_RS03555	COG4565	transcriptional regulatory protein
HD73_RS03560	COG3493	citrate carrier protein
HD73_RS03565	COG0281	malic enzyme
HD73_RS03575	COG0697	spore germination
HD73_RS03580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS03590	COG5002	protein histidine kinase activity
HD73_RS03595	COG0745	RESPONSE REGULATOR receiver
HD73_RS03610	COG0454	-acetyltransferase
HD73_RS03610	COG0456	acetyltransferase
HD73_RS03615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HD73_RS03620	COG3383	formate dehydrogenase (NAD+) activity
HD73_RS03625	COG2427	Protein of unknown function (DUF1641)
HD73_RS03640	COG0531	amino acid
HD73_RS03650	COG0640	Transcriptional regulator
HD73_RS03655	COG2217	Heavy metal translocating P-type atpase
HD73_RS03660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HD73_RS03675	COG3227	Zinc metalloprotease (Elastase)
HD73_RS03695	COG2720	vancomycin resistance protein
HD73_RS03700	COG1316	TRANSCRIPTIONal
HD73_RS03705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS03720	COG3344	reverse transcriptase
HD73_RS03730	COG0346	lactoylglutathione lyase activity
HD73_RS03735	COG1253	flavin adenine dinucleotide binding
HD73_RS03745	COG1620	l-lactate permease
HD73_RS03770	COG3104	oligopeptide transport
HD73_RS03775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS03780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS03785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS03795	COG2226	methyltransferase
HD73_RS03805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HD73_RS03815	COG4548	von Willebrand factor, type A
HD73_RS03820	COG0714	Associated with various cellular activities
HD73_RS03840	COG0531	amino acid
HD73_RS03845	COG2188	Transcriptional regulator
HD73_RS03850	COG1263	PTS System
HD73_RS03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD73_RS03855	COG0366	Alpha amylase catalytic
HD73_RS03870	COG0697	spore germination
HD73_RS03875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HD73_RS03880	COG1115	amino acid carrier protein
HD73_RS03890	COG1126	abc transporter atp-binding protein
HD73_RS03895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD73_RS03900	COG0765	amino acid transport
HD73_RS03905	COG0765	amino acid transport
HD73_RS03910	COG0833	amino acid
HD73_RS03925	COG1595	DNA-templated transcription, initiation
HD73_RS03935	COG2378	regulation of single-species biofilm formation
HD73_RS03940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HD73_RS03945	COG5002	protein histidine kinase activity
HD73_RS03975	COG2271	Major facilitator Superfamily
HD73_RS03980	COG1846	Transcriptional regulator
HD73_RS03985	COG0477	Major facilitator Superfamily
HD73_RS03990	COG1609	Transcriptional regulator
HD73_RS03995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HD73_RS04010	COG1172	Belongs to the binding-protein-dependent transport system permease family
HD73_RS04015	COG1879	ABC-type sugar transport system periplasmic component
HD73_RS04045	COG1063	alcohol dehydrogenase
HD73_RS04055	COG2801	Transposase and inactivated derivatives
HD73_RS04085	COG1396	sequence-specific DNA binding
HD73_RS04175	COG0582	viral genome integration into host DNA
HD73_RS04225	COG1802	Transcriptional regulator
HD73_RS04225	COG4626	Terminase
HD73_RS04235	COG0740	serine-type endopeptidase activity
HD73_RS04285	COG3344	reverse transcriptase
HD73_RS04350	COG1674	ftsk spoiiie
HD73_RS04395	COG0840	transmembrane signaling receptor activity
HD73_RS04400	COG3584	3D domain protein
HD73_RS04400	COG3583	domain protein
HD73_RS04405	COG1476	TRANSCRIPTIONal
HD73_RS04425	COG3104	oligopeptide transport
HD73_RS04430	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS04445	COG1113	amino acid transport
HD73_RS04450	COG2252	PERMEase
HD73_RS04465	COG2153	protein acetylation
HD73_RS04475	COG0475	glutathione-regulated potassium exporter activity
HD73_RS04475	COG0569	domain protein
HD73_RS04480	COG0475	glutathione-regulated potassium exporter activity
HD73_RS04480	COG0569	domain protein
HD73_RS04490	COG1845	cytochrome c oxidase, subunit III
HD73_RS04495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HD73_RS04505	COG0833	amino acid
HD73_RS04510	COG4990	cell redox homeostasis
HD73_RS04525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HD73_RS04530	COG0697	spore germination
HD73_RS04535	COG0531	amino acid
HD73_RS04550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HD73_RS04555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HD73_RS04560	COG1918	ferrous iron import across plasma membrane
HD73_RS04560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HD73_RS04565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HD73_RS04570	COG0573	inorganic phosphate transmembrane transporter activity
HD73_RS04575	COG0581	inorganic phosphate transmembrane transporter activity
HD73_RS04580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HD73_RS04700	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HD73_RS04730	COG1116	anion transmembrane transporter activity
HD73_RS04735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HD73_RS04740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HD73_RS04745	COG0352	thiamine-phosphate diphosphorylase activity
HD73_RS04750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD73_RS04755	COG2104	thiamine diphosphate biosynthetic process
HD73_RS04765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HD73_RS04770	COG0351	phosphomethylpyrimidine kinase
HD73_RS04810	COG2205	protein histidine kinase activity
HD73_RS04815	COG2814	Major facilitator Superfamily
HD73_RS04820	COG1846	Transcriptional regulator
HD73_RS04845	COG1136	(ABC) transporter
HD73_RS04855	COG2252	PERMEase
HD73_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS04915	COG2801	Transposase and inactivated derivatives
HD73_RS04930	COG0778	Nitroreductase
HD73_RS04935	COG2719	SpoVR family
HD73_RS04945	COG3591	Belongs to the peptidase S1B family
HD73_RS04955	COG0446	pyridine nucleotide-disulphide oxidoreductase
HD73_RS04960	COG1937	Protein conserved in bacteria
HD73_RS04965	COG0425	Belongs to the sulfur carrier protein TusA family
HD73_RS04965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD73_RS04970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS04970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD73_RS04975	COG0425	Belongs to the sulfur carrier protein TusA family
HD73_RS04990	COG2210	Belongs to the sulfur carrier protein TusA family
HD73_RS04995	COG0730	response to heat
HD73_RS05005	COG1316	TRANSCRIPTIONal
HD73_RS05010	COG0604	alcohol dehydrogenase
HD73_RS05015	COG1283	sodium-dependent phosphate transmembrane transporter activity
HD73_RS05030	COG3711	transcriptional antiterminator
HD73_RS05030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HD73_RS05035	COG1447	Phosphotransferase system cellobiose-specific component IIA
HD73_RS05040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HD73_RS05065	COG1388	LysM domain
HD73_RS05065	COG3584	3D domain protein
HD73_RS05070	COG0577	efflux transmembrane transporter activity
HD73_RS05075	COG1136	(ABC) transporter
HD73_RS05085	COG5522	Integral membrane protein (intg_mem_TP0381)
HD73_RS05100	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS05105	COG3546	catalase activity
HD73_RS05175	COG0531	amino acid
HD73_RS05180	COG0475	glutathione-regulated potassium exporter activity
HD73_RS05190	COG1737	Transcriptional regulator
HD73_RS05200	COG1263	PTS System
HD73_RS05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD73_RS05210	COG2259	Doxx family
HD73_RS05230	COG1522	sequence-specific DNA binding
HD73_RS05235	COG0165	Argininosuccinate lyase
HD73_RS05235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HD73_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS05260	COG1309	transcriptional regulator
HD73_RS05265	COG2814	Major facilitator Superfamily
HD73_RS05270	COG1733	regulation of RNA biosynthetic process
HD73_RS05285	COG4533	DNA binding
HD73_RS05290	COG2211	Major facilitator Superfamily
HD73_RS05300	COG0693	protein deglycase activity
HD73_RS05305	COG0753	catalase activity
HD73_RS05330	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS05340	COG1132	(ABC) transporter
HD73_RS05345	COG1132	(ABC) transporter
HD73_RS05350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD73_RS05355	COG0765	amino acid transport
HD73_RS05360	COG1126	abc transporter atp-binding protein
HD73_RS05375	COG0189	ligase activity
HD73_RS05405	COG0028	Belongs to the TPP enzyme family
HD73_RS05410	COG3527	Alpha-acetolactate decarboxylase
HD73_RS05425	COG0561	phosphatase activity
HD73_RS05435	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS05435	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS05440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HD73_RS05445	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS05460	COG0659	secondary active sulfate transmembrane transporter activity
HD73_RS05465	COG2244	polysaccharide biosynthetic process
HD73_RS05485	COG1024	Enoyl-CoA hydratase
HD73_RS05505	COG1363	Peptidase, m42
HD73_RS05545	COG0601	transmembrane transport
HD73_RS05550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HD73_RS05555	COG0444	Belongs to the ABC transporter superfamily
HD73_RS05560	COG4608	Belongs to the ABC transporter superfamily
HD73_RS05575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS05595	COG2801	Transposase and inactivated derivatives
HD73_RS05675	COG0477	Major facilitator Superfamily
HD73_RS05680	COG3290	protein histidine kinase activity
HD73_RS05685	COG4565	transcriptional regulatory protein
HD73_RS05690	COG3181	Tripartite tricarboxylate transporter family receptor
HD73_RS05695	COG0494	nUDIX hydrolase
HD73_RS05710	COG0305	Participates in initiation and elongation during chromosome replication
HD73_RS05725	COG0305	Participates in initiation and elongation during chromosome replication
HD73_RS05750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HD73_RS05755	COG1288	antiporter activity
HD73_RS05765	COG1842	Phage shock protein A
HD73_RS05775	COG0477	Major facilitator Superfamily
HD73_RS05790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS05805	COG2801	Transposase and inactivated derivatives
HD73_RS05845	COG2020	methyltransferase activity
HD73_RS05870	COG3344	reverse transcriptase
HD73_RS05885	COG1073	alpha beta
HD73_RS05920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HD73_RS05925	COG1522	sequence-specific DNA binding
HD73_RS05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HD73_RS05970	COG2814	Major facilitator Superfamily
HD73_RS05975	COG0640	Transcriptional regulator
HD73_RS06000	COG2376	Dihydroxyacetone kinase
HD73_RS06055	COG2373	Large extracellular alpha-helical protein
HD73_RS06125	COG1191	sigma factor activity
HD73_RS06135	COG2208	phosphoserine phosphatase activity
HD73_RS06140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HD73_RS06145	COG5002	protein histidine kinase activity
HD73_RS06145	COG2205	protein histidine kinase activity
HD73_RS06145	COG0784	Response regulator, receiver
HD73_RS06185	COG2186	Transcriptional regulator
HD73_RS06195	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HD73_RS06215	COG0420	3'-5' exonuclease activity
HD73_RS06220	COG4717	serine-type aminopeptidase activity
HD73_RS06245	COG0346	lactoylglutathione lyase activity
HD73_RS06250	COG0346	lactoylglutathione lyase activity
HD73_RS06255	COG0457	Tetratricopeptide repeat
HD73_RS06280	COG2140	Oxalate decarboxylase
HD73_RS06285	COG3620	sequence-specific DNA binding
HD73_RS06290	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HD73_RS06295	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HD73_RS06305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HD73_RS06320	COG1595	DNA-templated transcription, initiation
HD73_RS06330	COG0772	Belongs to the SEDS family
HD73_RS06335	COG3973	AAA domain
HD73_RS06365	COG4980	gas vesicle protein
HD73_RS06370	COG0537	adenosine 5'-monophosphoramidase activity
HD73_RS06375	COG1131	(ABC) transporter
HD73_RS06380	COG4473	ABC transporter
HD73_RS06390	COG1309	transcriptional regulator
HD73_RS06400	COG3402	PFAM membrane-flanked domain
HD73_RS06405	COG3428	Bacterial PH domain
HD73_RS06440	COG0697	spore germination
HD73_RS06445	COG3402	PFAM membrane-flanked domain
HD73_RS06450	COG3428	Bacterial PH domain
HD73_RS06455	COG2329	Antibiotic biosynthesis monooxygenase
HD73_RS06460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HD73_RS06475	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HD73_RS06510	COG1309	transcriptional regulator
HD73_RS06515	COG1511	domain protein
HD73_RS06515	COG1511	domain protein
HD73_RS06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS06560	COG1234	tRNA 3'-trailer cleavage
HD73_RS06565	COG0095	Lipoate-protein ligase
HD73_RS06580	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS06590	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HD73_RS06600	COG4208	sulfate ABC transporter
HD73_RS06685	COG1309	transcriptional regulator
HD73_RS06690	COG1073	alpha beta
HD73_RS06695	COG1408	metallophosphoesterase
HD73_RS06700	COG1078	dGTPase activity
HD73_RS06710	COG1595	DNA-templated transcription, initiation
HD73_RS06715	COG2207	Transcriptional regulator
HD73_RS06715	COG3708	Transcriptional regulator
HD73_RS06730	COG0745	RESPONSE REGULATOR receiver
HD73_RS06750	COG0501	Belongs to the peptidase M48B family
HD73_RS06755	COG0840	transmembrane signaling receptor activity
HD73_RS06760	COG3693	PFAM glycoside hydrolase, family 10
HD73_RS06770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HD73_RS06775	COG2224	Isocitrate lyase
HD73_RS06790	COG1278	Cold shock
HD73_RS06810	COG0398	Pfam SNARE associated Golgi protein
HD73_RS06870	COG0179	Fumarylacetoacetate (FAA) hydrolase
HD73_RS06895	COG0367	asparagine synthase
HD73_RS06910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HD73_RS07005	COG3331	DNA recombination
HD73_RS07025	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS07060	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS07130	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS07135	COG4824	toxin secretion phage lysis holin
HD73_RS07140	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS07140	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS07140	COG1388	LysM domain
HD73_RS07165	COG0367	asparagine synthase
HD73_RS07175	COG0753	catalase activity
HD73_RS07185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HD73_RS07205	COG3339	Conserved Protein
HD73_RS07210	COG0004	ammonium transporteR
HD73_RS07230	COG2996	Protein conserved in bacteria
HD73_RS07255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS07270	COG0561	phosphatase activity
HD73_RS07295	COG2267	carboxylic ester hydrolase activity
HD73_RS07310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HD73_RS07315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HD73_RS07320	COG5504	Zn-dependent protease
HD73_RS07330	COG0180	Tryptophanyl-tRNA synthetase
HD73_RS07345	COG4166	transmembrane transport
HD73_RS07350	COG0601	transmembrane transport
HD73_RS07355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HD73_RS07360	COG0444	Belongs to the ABC transporter superfamily
HD73_RS07365	COG4608	Belongs to the ABC transporter superfamily
HD73_RS07370	COG0534	Mate efflux family protein
HD73_RS07375	COG4166	transmembrane transport
HD73_RS07395	COG0861	Integral membrane protein TerC family
HD73_RS07405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HD73_RS07415	COG1164	Oligoendopeptidase f
HD73_RS07430	COG2346	COG2346, Truncated hemoglobins
HD73_RS07435	COG4116	CYTH
HD73_RS07445	COG2357	RelA SpoT domain protein
HD73_RS07455	COG0564	pseudouridine synthase activity
HD73_RS07470	COG0772	Belongs to the SEDS family
HD73_RS07475	COG1216	Glycosyl transferase, family 2
HD73_RS07495	COG0463	Glycosyl transferase, family 2
HD73_RS07495	COG0457	Tetratricopeptide repeat
HD73_RS07515	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HD73_RS07530	COG1091	dTDP-4-dehydrorhamnose reductase activity
HD73_RS07575	COG2153	protein acetylation
HD73_RS07585	COG2382	esterase
HD73_RS07610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HD73_RS07625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HD73_RS07625	COG0512	Glutamine amidotransferase of anthranilate synthase
HD73_RS07660	COG1620	l-lactate permease
HD73_RS07665	COG5634	Uncharacterized conserved protein (DUF2278)
HD73_RS07710	COG2801	Transposase and inactivated derivatives
HD73_RS07715	COG2226	methyltransferase
HD73_RS07735	COG0508	dehydrogenase complex catalyzes the overall conversion of
HD73_RS07745	COG1476	TRANSCRIPTIONal
HD73_RS07780	COG2801	Transposase and inactivated derivatives
HD73_RS07795	COG4152	abc transporter atp-binding protein
HD73_RS07800	COG1668	transmembrane transport
HD73_RS07820	COG2226	methyltransferase
HD73_RS07830	COG1686	Belongs to the peptidase S11 family
HD73_RS07835	COG0681	Belongs to the peptidase S26 family
HD73_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS07880	COG1176	ABC-type spermidine putrescine transport system, permease component I
HD73_RS07885	COG1177	transmembrane transport
HD73_RS07900	COG2409	Drug exporters of the RND superfamily
HD73_RS07910	COG0564	pseudouridine synthase activity
HD73_RS07920	COG2340	Cysteine-rich secretory protein family
HD73_RS07925	COG0247	lactate metabolic process
HD73_RS07930	COG0277	FAD linked oxidase domain protein
HD73_RS07935	COG3835	regulator
HD73_RS07945	COG0745	RESPONSE REGULATOR receiver
HD73_RS07950	COG5002	protein histidine kinase activity
HD73_RS07955	COG2186	Transcriptional regulator
HD73_RS07975	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HD73_RS07985	COG2116	formate transmembrane transporter activity
HD73_RS07990	COG0861	Integral membrane protein TerC family
HD73_RS07995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HD73_RS08005	COG2030	dehydratase
HD73_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS08030	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS08035	COG3243	poly(R)-hydroxyalkanoic acid synthase
HD73_RS08045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HD73_RS08060	COG1840	ABC-type Fe3 transport system, periplasmic component
HD73_RS08065	COG3842	ATPase activity
HD73_RS08090	COG1349	DNA-binding transcription factor activity
HD73_RS08105	COG0235	Class ii aldolase
HD73_RS08115	COG2861	carbohydrate metabolic process
HD73_RS08125	COG3852	Histidine kinase
HD73_RS08130	COG1846	Transcriptional regulator
HD73_RS08140	COG2318	DinB family
HD73_RS08150	COG5002	protein histidine kinase activity
HD73_RS08160	COG0720	synthase
HD73_RS08175	COG4873	Protein conserved in bacteria
HD73_RS08215	COG1780	Probably involved in ribonucleotide reductase function
HD73_RS08220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HD73_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HD73_RS08230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HD73_RS08235	COG1725	Transcriptional regulator
HD73_RS08240	COG1131	(ABC) transporter
HD73_RS08250	COG1131	(ABC) transporter
HD73_RS08270	COG1522	sequence-specific DNA binding
HD73_RS08280	COG1335	isochorismatase
HD73_RS08290	COG1619	proteins homologs of microcin C7 resistance protein MccF
HD73_RS08295	COG2070	2-Nitropropane dioxygenase
HD73_RS08300	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HD73_RS08310	COG1696	Membrane protein involved in D-alanine export
HD73_RS08340	COG0716	FMN binding
HD73_RS08390	COG1846	Transcriptional regulator
HD73_RS08400	COG1301	dicarboxylic acid transport
HD73_RS08405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HD73_RS08410	COG4709	membrane
HD73_RS08415	COG3874	Sporulation protein YtfJ
HD73_RS08445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HD73_RS08450	COG0028	Belongs to the TPP enzyme family
HD73_RS08455	COG0440	acetolactate synthase activity
HD73_RS08530	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HD73_RS08545	COG1183	phosphatidylcholine synthase activity
HD73_RS08550	COG1368	sulfuric ester hydrolase activity
HD73_RS08560	COG0019	diaminopimelate decarboxylase activity
HD73_RS08580	COG0529	Catalyzes the synthesis of activated sulfate
HD73_RS08585	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HD73_RS08605	COG1648	precorrin-2 dehydrogenase activity
HD73_RS08615	COG0733	neurotransmitter:sodium symporter activity
HD73_RS08635	COG1757	Na H antiporter
HD73_RS08650	COG4758	membrane
HD73_RS08655	COG4585	Histidine kinase
HD73_RS08660	COG2197	response regulator
HD73_RS08670	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS08725	COG0730	response to heat
HD73_RS08730	COG0306	phosphate transporter
HD73_RS08735	COG1392	Phosphate transport regulator
HD73_RS08740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HD73_RS08755	COG3852	Histidine kinase
HD73_RS08760	COG1801	Protein of unknown function DUF72
HD73_RS08770	COG0582	viral genome integration into host DNA
HD73_RS08775	COG5002	protein histidine kinase activity
HD73_RS08790	COG0392	lysyltransferase activity
HD73_RS08790	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HD73_RS08805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HD73_RS08810	COG1686	Belongs to the peptidase S11 family
HD73_RS08815	COG2715	membrane protein required for spore maturation
HD73_RS08820	COG0700	Nucleoside recognition
HD73_RS08825	COG1187	pseudouridine synthase activity
HD73_RS08835	COG1333	cytochrome c biogenesis protein
HD73_RS08840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HD73_RS08845	COG0745	RESPONSE REGULATOR receiver
HD73_RS08850	COG5002	protein histidine kinase activity
HD73_RS08855	COG2096	Adenosyltransferase
HD73_RS08870	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HD73_RS08875	COG1141	Ferredoxin
HD73_RS08885	COG0514	ATP-dependent DNA helicase (RecQ)
HD73_RS08890	COG1266	CAAX protease self-immunity
HD73_RS08900	COG1408	metallophosphoesterase
HD73_RS08905	COG0789	Transcriptional regulator
HD73_RS08915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HD73_RS08935	COG0492	ferredoxin-NADP+ reductase activity
HD73_RS08940	COG0252	asparaginase activity
HD73_RS09010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HD73_RS09025	COG0142	geranyltranstransferase activity
HD73_RS09035	COG0142	geranyltranstransferase activity
HD73_RS09065	COG0457	Tetratricopeptide repeat
HD73_RS09085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HD73_RS09090	COG2010	Cytochrome c
HD73_RS09090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HD73_RS09095	COG4347	Protein of unknown function (DUF1405)
HD73_RS09110	COG2738	Putative neutral zinc metallopeptidase
HD73_RS09120	COG2801	Transposase and inactivated derivatives
HD73_RS09130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS09135	COG1694	Mazg nucleotide pyrophosphohydrolase
HD73_RS09155	COG0438	transferase activity, transferring glycosyl groups
HD73_RS09195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HD73_RS09195	COG1199	ATP-dependent helicase activity
HD73_RS09215	COG3935	DnaD domain protein
HD73_RS09220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HD73_RS09230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HD73_RS09230	COG4499	WXG100 protein secretion system (Wss), protein YukC
HD73_RS09280	COG0116	Belongs to the methyltransferase superfamily
HD73_RS09290	COG1199	ATP-dependent helicase activity
HD73_RS09295	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HD73_RS09305	COG0024	Methionine aminopeptidase
HD73_RS09315	COG2233	PERMEase
HD73_RS09320	COG2311	Membrane
HD73_RS09325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HD73_RS09335	COG0456	acetyltransferase
HD73_RS09375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HD73_RS09390	COG3944	biosynthesis protein
HD73_RS09400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HD73_RS09415	COG1215	transferase activity, transferring glycosyl groups
HD73_RS09420	COG0438	transferase activity, transferring glycosyl groups
HD73_RS09435	COG0454	-acetyltransferase
HD73_RS09455	COG0328	RNA-DNA hybrid ribonuclease activity
HD73_RS09490	COG3403	YqcI/YcgG family
HD73_RS09495	COG1280	lysine exporter protein (LysE YggA)
HD73_RS09515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HD73_RS09520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HD73_RS09530	COG0475	glutathione-regulated potassium exporter activity
HD73_RS09535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HD73_RS09540	COG0789	Transcriptional regulator
HD73_RS09540	COG4978	Transcriptional regulator
HD73_RS09550	COG2323	membrane
HD73_RS09555	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HD73_RS09595	COG1923	regulation of RNA biosynthetic process
HD73_RS09605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HD73_RS09610	COG1360	Flagellar Motor Protein
HD73_RS09615	COG2201	protein-glutamate methylesterase activity
HD73_RS09620	COG2198	Histidine kinase
HD73_RS09620	COG0643	Histidine kinase
HD73_RS09625	COG1776	CheC inhibitor of MCP methylation
HD73_RS09625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HD73_RS09640	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HD73_RS09660	COG1256	bacterial-type flagellum assembly
HD73_RS09665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HD73_RS09685	COG1815	bacterial-type flagellum-dependent cell motility
HD73_RS09690	COG1558	bacterial-type flagellum-dependent cell motility
HD73_RS09700	COG1766	The M ring may be actively involved in energy transduction
HD73_RS09705	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HD73_RS09715	COG1157	protein secretion by the type III secretion system
HD73_RS09750	COG0784	Response regulator, receiver
HD73_RS09750	COG0835	chemotaxis
HD73_RS09760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HD73_RS09765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HD73_RS09770	COG0741	lytic transglycosylase activity
HD73_RS09780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HD73_RS09785	COG1776	CheC inhibitor of MCP methylation
HD73_RS09785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HD73_RS09795	COG1338	Plays a role in the flagellum-specific transport system
HD73_RS09800	COG1987	bacterial-type flagellum assembly
HD73_RS09810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HD73_RS09815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HD73_RS09820	COG1419	protein localization to endoplasmic reticulum
HD73_RS09825	COG4786	Flagellar basal body rod
HD73_RS09830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HD73_RS09890	COG0583	DNA-binding transcription factor activity
HD73_RS09895	COG3842	ATPase activity
HD73_RS09900	COG0725	ABC transporter, periplasmic molybdate-binding protein
HD73_RS09935	COG0406	alpha-ribazole phosphatase activity
HD73_RS09950	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS09970	COG0367	asparagine synthase
HD73_RS10000	COG1802	Transcriptional regulator
HD73_RS10005	COG0697	spore germination
HD73_RS10015	COG0523	cobalamin synthesis protein
HD73_RS10020	COG0701	Predicted permease
HD73_RS10035	COG1757	Na H antiporter
HD73_RS10040	COG0789	Transcriptional regulator
HD73_RS10075	COG0534	Mate efflux family protein
HD73_RS10080	COG3340	Belongs to the peptidase S51 family
HD73_RS10100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD73_RS10120	COG2733	membrane
HD73_RS10155	COG1131	(ABC) transporter
HD73_RS10175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HD73_RS10180	COG0528	UMP kinase activity
HD73_RS10195	COG1027	Aspartate ammonia-lyase
HD73_RS10200	COG0281	malic enzyme
HD73_RS10205	COG4191	Histidine kinase
HD73_RS10210	COG0784	Response regulator, receiver
HD73_RS10215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HD73_RS10240	COG2801	Transposase and inactivated derivatives
HD73_RS10250	COG3620	sequence-specific DNA binding
HD73_RS10290	COG2814	Major facilitator Superfamily
HD73_RS10310	COG1695	Transcriptional regulator
HD73_RS10320	COG0477	Major facilitator Superfamily
HD73_RS10330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HD73_RS10335	COG2223	nitrite transmembrane transporter activity
HD73_RS10340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HD73_RS10360	COG0733	neurotransmitter:sodium symporter activity
HD73_RS10365	COG5566	PFAM Mor transcription activator
HD73_RS10370	COG2323	membrane
HD73_RS10390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HD73_RS10400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HD73_RS10405	COG0028	Belongs to the TPP enzyme family
HD73_RS10425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HD73_RS10450	COG2814	Major facilitator Superfamily
HD73_RS10455	COG3384	dioxygenase
HD73_RS10465	COG3279	Response regulator of the LytR AlgR family
HD73_RS10470	COG0427	acetyl-CoA hydrolase
HD73_RS10490	COG4166	transmembrane transport
HD73_RS10495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS10500	COG1914	H( )-stimulated, divalent metal cation uptake system
HD73_RS10515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HD73_RS10525	COG0531	amino acid
HD73_RS10560	COG1309	transcriptional regulator
HD73_RS10565	COG2390	Transcriptional regulator
HD73_RS10575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS10580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HD73_RS10595	COG4846	Membrane protein involved in cytochrome C biogenesis
HD73_RS10605	COG0006	proline dipeptidase activity
HD73_RS10615	COG2132	Multicopper oxidase
HD73_RS10625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HD73_RS10645	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS10655	COG1276	copper resistance
HD73_RS10655	COG2372	response to copper ion
HD73_RS10660	COG4549	nuclear export factor GLE1
HD73_RS10665	COG0697	spore germination
HD73_RS10670	COG0583	DNA-binding transcription factor activity
HD73_RS10675	COG1959	2 iron, 2 sulfur cluster binding
HD73_RS10680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HD73_RS10685	COG0778	Nitroreductase
HD73_RS10700	COG0628	permease
HD73_RS10710	COG1231	oxidoreductase activity
HD73_RS10715	COG0523	cobalamin synthesis protein
HD73_RS10725	COG0411	ABC transporter
HD73_RS10745	COG0583	DNA-binding transcription factor activity
HD73_RS10755	COG1942	4-Oxalocrotonate Tautomerase
HD73_RS10775	COG1271	oxidase subunit
HD73_RS10780	COG1294	oxidase, subunit
HD73_RS10785	COG4988	ABC transporter
HD73_RS10790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HD73_RS10800	COG1216	Glycosyl transferase, family 2
HD73_RS10840	COG1686	Belongs to the peptidase S11 family
HD73_RS10855	COG0791	NLP P60 protein
HD73_RS10855	COG1388	LysM domain
HD73_RS10865	COG1132	(ABC) transporter
HD73_RS10870	COG0745	RESPONSE REGULATOR receiver
HD73_RS10875	COG5002	protein histidine kinase activity
HD73_RS10880	COG0300	oxidoreductase activity
HD73_RS10910	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS10915	COG0460	homoserine dehydrogenase
HD73_RS10940	COG1316	TRANSCRIPTIONal
HD73_RS10950	COG0745	RESPONSE REGULATOR receiver
HD73_RS10955	COG5002	protein histidine kinase activity
HD73_RS10970	COG1285	pathogenesis
HD73_RS10975	COG1247	-acetyltransferase
HD73_RS11020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HD73_RS11030	COG1082	Xylose isomerase domain protein TIM barrel
HD73_RS11040	COG2814	Major facilitator Superfamily
HD73_RS11045	COG1279	arginine transmembrane transporter activity
HD73_RS11050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS11060	COG1752	Esterase of the alpha-beta hydrolase superfamily
HD73_RS11095	COG0577	efflux transmembrane transporter activity
HD73_RS11100	COG2002	toxin-antitoxin pair type II binding
HD73_RS11105	COG1404	Belongs to the peptidase S8 family
HD73_RS11110	COG0640	Transcriptional regulator
HD73_RS11115	COG0667	Aldo Keto reductase
HD73_RS11120	COG2814	Major facilitator Superfamily
HD73_RS11130	COG3152	Membrane
HD73_RS11155	COG0840	transmembrane signaling receptor activity
HD73_RS11175	COG3949	Membrane
HD73_RS11180	COG0783	Belongs to the Dps family
HD73_RS11195	COG2801	Transposase and inactivated derivatives
HD73_RS11205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HD73_RS11215	COG1231	oxidoreductase activity
HD73_RS11220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS11225	COG4989	oxidoreductase activity
HD73_RS11235	COG0523	cobalamin synthesis protein
HD73_RS11240	COG0456	acetyltransferase
HD73_RS11245	COG0803	Belongs to the bacterial solute-binding protein 9 family
HD73_RS11265	COG3344	reverse transcriptase
HD73_RS11275	COG0702	epimerase
HD73_RS11285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HD73_RS11295	COG4166	transmembrane transport
HD73_RS11320	COG5337	Spore coat protein CotH
HD73_RS11325	COG1051	belongs to the nudix hydrolase family
HD73_RS11330	COG0586	Pfam SNARE associated Golgi protein
HD73_RS11335	COG2244	polysaccharide biosynthetic process
HD73_RS11345	COG0701	Predicted permease
HD73_RS11350	COG3689	TIGRFAM TIGR03943 family protein
HD73_RS11355	COG1607	acyl-coa hydrolase
HD73_RS11360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HD73_RS11375	COG0702	epimerase
HD73_RS11380	COG2839	Protein conserved in bacteria
HD73_RS11385	COG1253	flavin adenine dinucleotide binding
HD73_RS11400	COG2801	Transposase and inactivated derivatives
HD73_RS11405	COG2963	transposase activity
HD73_RS11410	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS11415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HD73_RS11435	COG0860	N-Acetylmuramoyl-L-alanine amidase
HD73_RS11460	COG2211	Major facilitator Superfamily
HD73_RS11475	COG0860	N-Acetylmuramoyl-L-alanine amidase
HD73_RS11485	COG0561	phosphatase activity
HD73_RS11515	COG3646	Phage regulatory protein
HD73_RS11590	COG0582	viral genome integration into host DNA
HD73_RS11640	COG4626	Terminase
HD73_RS11640	COG1802	Transcriptional regulator
HD73_RS11650	COG0740	serine-type endopeptidase activity
HD73_RS11700	COG3344	reverse transcriptase
HD73_RS11735	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS11745	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS11785	COG0561	phosphatase activity
HD73_RS11800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HD73_RS11810	COG1819	glycosyl
HD73_RS11815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS11820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS11850	COG0456	acetyltransferase
HD73_RS11885	COG4499	WXG100 protein secretion system (Wss), protein YukC
HD73_RS11980	COG3874	Sporulation protein YtfJ
HD73_RS12005	COG2226	methyltransferase
HD73_RS12025	COG1082	Xylose isomerase domain protein TIM barrel
HD73_RS12030	COG0346	lactoylglutathione lyase activity
HD73_RS12040	COG0604	alcohol dehydrogenase
HD73_RS12050	COG1595	DNA-templated transcription, initiation
HD73_RS12065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HD73_RS12065	COG0426	domain, Protein
HD73_RS12080	COG0386	Belongs to the glutathione peroxidase family
HD73_RS12085	COG1305	Transglutaminase-like
HD73_RS12090	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HD73_RS12095	COG0714	Associated with various cellular activities
HD73_RS12105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HD73_RS12110	COG1140	nitrate reductase beta subunit
HD73_RS12115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HD73_RS12120	COG2181	nitrate reductase activity
HD73_RS12125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HD73_RS12130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HD73_RS12135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HD73_RS12140	COG0303	'Molybdopterin
HD73_RS12145	COG0314	molybdopterin synthase activity
HD73_RS12150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HD73_RS12155	COG2223	nitrite transmembrane transporter activity
HD73_RS12165	COG1648	precorrin-2 dehydrogenase activity
HD73_RS12175	COG1587	Uroporphyrinogen-III synthase
HD73_RS12175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HD73_RS12180	COG2146	nitrite reductase [NAD(P)H] activity
HD73_RS12185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HD73_RS12190	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HD73_RS12225	COG2359	stage V sporulation protein S
HD73_RS12250	COG0730	response to heat
HD73_RS12275	COG0457	Tetratricopeptide repeat
HD73_RS12290	COG1418	mRNA catabolic process
HD73_RS12295	COG0488	(ABC) transporter
HD73_RS12405	COG0629	single-stranded DNA binding
HD73_RS12415	COG1413	lyase activity
HD73_RS12430	COG2136	Putative SAM-dependent methyltransferase
HD73_RS12430	COG2521	methyltransferase
HD73_RS12435	COG0018	arginyl-trna synthetase
HD73_RS12480	COG2801	Transposase and inactivated derivatives
HD73_RS12485	COG2963	transposase activity
HD73_RS12495	COG0017	Asparaginyl-tRNA synthetase
HD73_RS12500	COG0733	neurotransmitter:sodium symporter activity
HD73_RS12525	COG2610	gluconate transmembrane transporter activity
HD73_RS12535	COG1794	racemase activity, acting on amino acids and derivatives
HD73_RS12545	COG0456	acetyltransferase
HD73_RS12555	COG3655	Transcriptional regulator
HD73_RS12560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HD73_RS12570	COG1131	(ABC) transporter
HD73_RS12575	COG4473	ABC transporter
HD73_RS12585	COG0546	phosphoglycolate phosphatase activity
HD73_RS12600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HD73_RS12615	COG0768	penicillin binding
HD73_RS12625	COG0204	Acyl-transferase
HD73_RS12630	COG1272	protein, Hemolysin III
HD73_RS12640	COG0805	protein transport
HD73_RS12650	COG1307	EDD domain protein, DegV family
HD73_RS12660	COG1999	signal sequence binding
HD73_RS12665	COG0071	Belongs to the small heat shock protein (HSP20) family
HD73_RS12670	COG0367	asparagine synthase
HD73_RS12690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS12695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HD73_RS12715	COG1335	isochorismatase
HD73_RS12725	COG0668	transmembrane transport
HD73_RS12730	COG4585	Histidine kinase
HD73_RS12730	COG2203	Gaf domain
HD73_RS12735	COG2197	response regulator
HD73_RS12740	COG1737	Transcriptional regulator
HD73_RS12745	COG0384	phenazine biosynthesis protein PhzF
HD73_RS12750	COG1064	alcohol dehydrogenase
HD73_RS12775	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HD73_RS12810	COG1125	glycine betaine transport
HD73_RS12810	COG0517	IMP dehydrogenase activity
HD73_RS12815	COG1174	glycine betaine transport
HD73_RS12850	COG1253	flavin adenine dinucleotide binding
HD73_RS12855	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS12860	COG5506	Protein of unknown function (DUF1694)
HD73_RS12875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HD73_RS12880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HD73_RS12885	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HD73_RS12890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HD73_RS12895	COG0456	acetyltransferase
HD73_RS12900	COG3829	transcription factor binding
HD73_RS12905	COG1509	lysine 2,3-aminomutase activity
HD73_RS12940	COG4991	sh3 domain protein
HD73_RS12940	COG3064	Membrane
HD73_RS12940	COG0515	serine threonine protein kinase
HD73_RS12950	COG0671	phosphoesterase, PA-phosphatase related
HD73_RS12955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HD73_RS12960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD73_RS13040	COG0300	oxidoreductase activity
HD73_RS13060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HD73_RS13060	COG4499	WXG100 protein secretion system (Wss), protein YukC
HD73_RS13070	COG2814	Major facilitator Superfamily
HD73_RS13075	COG4841	protein insertion into membrane
HD73_RS13080	COG0372	Belongs to the citrate synthase family
HD73_RS13085	COG2079	MmgE PrpD family protein
HD73_RS13090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HD73_RS13095	COG1960	acyl-CoA dehydrogenase activity
HD73_RS13100	COG2084	Dehydrogenase
HD73_RS13110	COG1280	lysine exporter protein (LysE YggA)
HD73_RS13115	COG1024	Enoyl-CoA hydratase
HD73_RS13130	COG0420	3'-5' exonuclease activity
HD73_RS13135	COG0419	ATPase involved in DNA repair
HD73_RS13160	COG2223	nitrite transmembrane transporter activity
HD73_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS13170	COG1169	isochorismate synthase
HD73_RS13175	COG1021	2,3-dihydroxybenzoate-AMP ligase
HD73_RS13180	COG1535	isochorismatase
HD73_RS13180	COG3433	isochorismatase activity
HD73_RS13185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HD73_RS13190	COG3251	PFAM MbtH domain protein
HD73_RS13195	COG2814	Major facilitator Superfamily
HD73_RS13210	COG0776	regulation of translation
HD73_RS13220	COG2318	DinB family
HD73_RS13245	COG2329	Antibiotic biosynthesis monooxygenase
HD73_RS13250	COG1187	pseudouridine synthase activity
HD73_RS13255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HD73_RS13260	COG1136	(ABC) transporter
HD73_RS13270	COG0028	Belongs to the TPP enzyme family
HD73_RS13310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HD73_RS13335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS13370	COG1247	-acetyltransferase
HD73_RS13395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HD73_RS13405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS13435	COG0583	DNA-binding transcription factor activity
HD73_RS13440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HD73_RS13460	COG0583	DNA-binding transcription factor activity
HD73_RS13465	COG2258	MOSC domain
HD73_RS13480	COG1132	(ABC) transporter
HD73_RS13485	COG1132	(ABC) transporter
HD73_RS13510	COG1396	sequence-specific DNA binding
HD73_RS13545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HD73_RS13550	COG1595	DNA-templated transcription, initiation
HD73_RS13575	COG1649	PFAM Uncharacterised BCR, COG1649
HD73_RS13595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HD73_RS13600	COG2971	BadF BadG BcrA BcrD
HD73_RS13620	COG1846	Transcriptional regulator
HD73_RS13640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS13660	COG1309	transcriptional regulator
HD73_RS13680	COG3615	Tellurite resistance protein tehB
HD73_RS13680	COG0500	methyltransferase
HD73_RS13695	COG3961	Belongs to the TPP enzyme family
HD73_RS13700	COG1846	Transcriptional regulator
HD73_RS13755	COG2002	toxin-antitoxin pair type II binding
HD73_RS13760	COG2963	transposase activity
HD73_RS13765	COG2801	Transposase and inactivated derivatives
HD73_RS13775	COG0730	response to heat
HD73_RS13780	COG0110	maltose O-acetyltransferase activity
HD73_RS13785	COG1686	Belongs to the peptidase S11 family
HD73_RS13795	COG2814	Major facilitator Superfamily
HD73_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS13855	COG0741	lytic transglycosylase activity
HD73_RS13865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS13870	COG2239	Acts as a magnesium transporter
HD73_RS13950	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS13950	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS13960	COG3831	ATPase activity
HD73_RS13990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HD73_RS14020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS14030	COG3850	Histidine kinase
HD73_RS14030	COG5002	protein histidine kinase activity
HD73_RS14035	COG0577	efflux transmembrane transporter activity
HD73_RS14055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HD73_RS14065	COG1690	Belongs to the RtcB family
HD73_RS14075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HD73_RS14095	COG2814	Major facilitator Superfamily
HD73_RS14170	COG0346	lactoylglutathione lyase activity
HD73_RS14185	COG1522	sequence-specific DNA binding
HD73_RS14190	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS14195	COG1309	transcriptional regulator
HD73_RS14200	COG2814	Major facilitator Superfamily
HD73_RS14210	COG0640	Transcriptional regulator
HD73_RS14215	COG0346	lactoylglutathione lyase activity
HD73_RS14220	COG0798	PFAM Bile acid sodium symporter
HD73_RS14230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS14240	COG1575	Belongs to the MenA family. Type 1 subfamily
HD73_RS14245	COG0456	acetyltransferase
HD73_RS14255	COG5609	conserved protein (DUF2294)
HD73_RS14260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HD73_RS14270	COG0288	reversible hydration of carbon dioxide
HD73_RS14275	COG0657	acetylesterase activity
HD73_RS14300	COG0415	Belongs to the DNA photolyase family
HD73_RS14345	COG0598	Magnesium transport protein CorA
HD73_RS14380	COG0583	DNA-binding transcription factor activity
HD73_RS14400	COG1335	isochorismatase
HD73_RS14405	COG2267	carboxylic ester hydrolase activity
HD73_RS14410	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS14430	COG2207	Transcriptional regulator
HD73_RS14455	COG5002	protein histidine kinase activity
HD73_RS14460	COG1063	alcohol dehydrogenase
HD73_RS14480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS14485	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS14490	COG1522	sequence-specific DNA binding
HD73_RS14505	COG3848	Pyruvate phosphate dikinase
HD73_RS14505	COG0574	Belongs to the PEP-utilizing enzyme family
HD73_RS14520	COG2963	transposase activity
HD73_RS14525	COG2801	Transposase and inactivated derivatives
HD73_RS14535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HD73_RS14545	COG0454	-acetyltransferase
HD73_RS14555	COG3314	Sporulation integral membrane protein YlbJ
HD73_RS14580	COG0640	Transcriptional regulator
HD73_RS14585	COG3142	Participates in the control of copper homeostasis
HD73_RS14595	COG1414	Transcriptional regulator
HD73_RS14600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HD73_RS14605	COG1984	allophanate hydrolase subunit 2
HD73_RS14640	COG0768	penicillin binding
HD73_RS14685	COG0833	amino acid
HD73_RS14695	COG0730	response to heat
HD73_RS14735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS14740	COG0697	spore germination
HD73_RS14755	COG0456	acetyltransferase
HD73_RS14760	COG0037	tRNA processing
HD73_RS14760	COG0590	tRNA wobble adenosine to inosine editing
HD73_RS14785	COG3831	ATPase activity
HD73_RS14785	COG4884	unkown
HD73_RS14805	COG1846	Transcriptional regulator
HD73_RS14810	COG0778	Nitroreductase
HD73_RS14855	COG0714	Associated with various cellular activities
HD73_RS14895	COG0753	catalase activity
HD73_RS14900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HD73_RS14970	COG0714	Associated with various cellular activities
HD73_RS15000	COG0346	lactoylglutathione lyase activity
HD73_RS15005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS15025	COG3655	Transcriptional regulator
HD73_RS15035	COG1785	Belongs to the alkaline phosphatase family
HD73_RS15050	COG3239	Fatty acid desaturase
HD73_RS15060	COG0833	amino acid
HD73_RS15065	COG1414	Transcriptional regulator
HD73_RS15070	COG4187	Peptidase family M20/M25/M40
HD73_RS15075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HD73_RS15090	COG2801	Transposase and inactivated derivatives
HD73_RS15100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS15120	COG2329	Antibiotic biosynthesis monooxygenase
HD73_RS15130	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS15150	COG1070	Carbohydrate kinase
HD73_RS15155	COG2390	Transcriptional regulator
HD73_RS15165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HD73_RS15175	COG1879	ABC-type sugar transport system periplasmic component
HD73_RS15195	COG0277	FAD linked oxidase domain protein
HD73_RS15205	COG3584	3D domain protein
HD73_RS15205	COG1388	LysM domain
HD73_RS15245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HD73_RS15245	COG1605	Chorismate mutase
HD73_RS15260	COG0287	Prephenate dehydrogenase
HD73_RS15275	COG1309	transcriptional regulator
HD73_RS15280	COG2409	Drug exporters of the RND superfamily
HD73_RS15280	COG1033	growth of symbiont in host cell
HD73_RS15290	COG2409	Drug exporters of the RND superfamily
HD73_RS15290	COG1033	growth of symbiont in host cell
HD73_RS15295	COG0488	(ABC) transporter
HD73_RS15300	COG1368	sulfuric ester hydrolase activity
HD73_RS15305	COG0861	Integral membrane protein TerC family
HD73_RS15315	COG0346	lactoylglutathione lyase activity
HD73_RS15320	COG4912	Dna alkylation repair
HD73_RS15340	COG0697	spore germination
HD73_RS15360	COG2746	aminoglycoside 3-N-acetyltransferase activity
HD73_RS15390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HD73_RS15395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HD73_RS15415	COG0628	permease
HD73_RS15465	COG1131	(ABC) transporter
HD73_RS15480	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HD73_RS15490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HD73_RS15495	COG0436	Aminotransferase
HD73_RS15535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HD73_RS15550	COG2261	transglycosylase associated protein
HD73_RS15570	COG2814	Major facilitator Superfamily
HD73_RS15570	COG0477	Major facilitator Superfamily
HD73_RS15580	COG0789	Transcriptional regulator
HD73_RS15585	COG1664	Polymer-forming cytoskeletal
HD73_RS15595	COG2814	Major facilitator Superfamily
HD73_RS15635	COG1307	EDD domain protein, DegV family
HD73_RS15640	COG1164	Oligoendopeptidase f
HD73_RS15650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HD73_RS15670	COG0745	RESPONSE REGULATOR receiver
HD73_RS15675	COG5002	protein histidine kinase activity
HD73_RS15675	COG3850	Histidine kinase
HD73_RS15720	COG0667	Aldo Keto reductase
HD73_RS15735	COG4948	Mandelate Racemase Muconate Lactonizing
HD73_RS15745	COG4166	transmembrane transport
HD73_RS15755	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HD73_RS15765	COG0586	Pfam SNARE associated Golgi protein
HD73_RS15805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD73_RS15810	COG3938	Belongs to the proline racemase family
HD73_RS15820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HD73_RS15825	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS15830	COG1115	amino acid carrier protein
HD73_RS15835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HD73_RS15840	COG1162	GTPase activity
HD73_RS15855	COG3397	chitin binding
HD73_RS15870	COG4637	Psort location Cytoplasmic, score
HD73_RS15885	COG2801	Transposase and inactivated derivatives
HD73_RS15905	COG2801	Transposase and inactivated derivatives
HD73_RS15925	COG0514	ATP-dependent DNA helicase (RecQ)
HD73_RS15930	COG2105	PFAM AIG2 family protein
HD73_RS15940	COG3973	AAA domain
HD73_RS15945	COG0456	acetyltransferase
HD73_RS15990	COG2315	Protein conserved in bacteria
HD73_RS15995	COG2226	methyltransferase
HD73_RS16000	COG2205	protein histidine kinase activity
HD73_RS16025	COG3397	chitin binding
HD73_RS16030	COG2153	protein acetylation
HD73_RS16060	COG0517	IMP dehydrogenase activity
HD73_RS16060	COG4175	Glycine betaine
HD73_RS16065	COG4176	ABC-type proline glycine betaine transport system permease component
HD73_RS16105	COG0456	acetyltransferase
HD73_RS16105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HD73_RS16110	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS16130	COG2814	Major facilitator Superfamily
HD73_RS16145	COG0022	dehydrogenase e1 component
HD73_RS16150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HD73_RS16155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HD73_RS16165	COG1959	2 iron, 2 sulfur cluster binding
HD73_RS16200	COG3284	Transcriptional regulator
HD73_RS16230	COG1309	transcriptional regulator
HD73_RS16270	COG2959	enzyme of heme biosynthesis
HD73_RS16285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS16325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS16330	COG0697	spore germination
HD73_RS16335	COG0201	protein transport
HD73_RS16350	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS16360	COG1523	belongs to the glycosyl hydrolase 13 family
HD73_RS16390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HD73_RS16405	COG0076	glutamate decarboxylase activity
HD73_RS16410	COG0657	acetylesterase activity
HD73_RS16415	COG1073	alpha beta
HD73_RS16420	COG0577	efflux transmembrane transporter activity
HD73_RS16425	COG1136	(ABC) transporter
HD73_RS16440	COG5002	protein histidine kinase activity
HD73_RS16445	COG0745	RESPONSE REGULATOR receiver
HD73_RS16450	COG1011	Hydrolase
HD73_RS16475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HD73_RS16495	COG0322	excinuclease ABC activity
HD73_RS16535	COG4667	esterase of the alpha-beta hydrolase superfamily
HD73_RS16560	COG3878	Protein conserved in bacteria
HD73_RS16585	COG0592	DNA-directed DNA polymerase activity
HD73_RS16600	COG2223	nitrite transmembrane transporter activity
HD73_RS16610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HD73_RS16645	COG0697	spore germination
HD73_RS16650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS16665	COG0584	glycerophosphoryl diester phosphodiesterase
HD73_RS16685	COG2814	Major facilitator Superfamily
HD73_RS16690	COG2814	Major facilitator Superfamily
HD73_RS16735	COG0768	penicillin binding
HD73_RS16740	COG0671	phosphoesterase, PA-phosphatase related
HD73_RS16745	COG0604	alcohol dehydrogenase
HD73_RS16750	COG5002	protein histidine kinase activity
HD73_RS16755	COG0745	RESPONSE REGULATOR receiver
HD73_RS16765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HD73_RS16780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HD73_RS16820	COG0582	viral genome integration into host DNA
HD73_RS16825	COG2205	protein histidine kinase activity
HD73_RS16845	COG1794	racemase activity, acting on amino acids and derivatives
HD73_RS16850	COG1819	glycosyl
HD73_RS16860	COG0768	penicillin binding
HD73_RS16865	COG5002	protein histidine kinase activity
HD73_RS16870	COG0561	phosphatase activity
HD73_RS16905	COG2124	cytochrome p450
HD73_RS16930	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS16965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HD73_RS16980	COG0460	homoserine dehydrogenase
HD73_RS17000	COG0577	efflux transmembrane transporter activity
HD73_RS17005	COG1136	(ABC) transporter
HD73_RS17015	COG0488	(ABC) transporter
HD73_RS17020	COG2205	protein histidine kinase activity
HD73_RS17025	COG3344	reverse transcriptase
HD73_RS17035	COG0745	RESPONSE REGULATOR receiver
HD73_RS17045	COG3773	Cell wall hydrolase
HD73_RS17060	COG3386	PFAM SMP-30 Gluconolaconase
HD73_RS17070	COG0693	protein deglycase activity
HD73_RS17075	COG2323	membrane
HD73_RS17140	COG1131	(ABC) transporter
HD73_RS17150	COG0583	DNA-binding transcription factor activity
HD73_RS17155	COG1942	4-Oxalocrotonate Tautomerase
HD73_RS17210	COG2207	Transcriptional regulator
HD73_RS17215	COG3227	Zinc metalloprotease (Elastase)
HD73_RS17230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HD73_RS17260	COG1686	Belongs to the peptidase S11 family
HD73_RS17275	COG0572	uridine kinase
HD73_RS17290	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS17315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HD73_RS17320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HD73_RS17325	COG1024	Enoyl-CoA hydratase
HD73_RS17330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HD73_RS17335	COG0511	ligase activity, forming carbon-carbon bonds
HD73_RS17340	COG0439	Biotin carboxylase
HD73_RS17345	COG1960	acyl-CoA dehydrogenase activity
HD73_RS17360	COG1309	transcriptional regulator
HD73_RS17370	COG1131	(ABC) transporter
HD73_RS17385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS17405	COG0768	penicillin binding
HD73_RS17415	COG1595	DNA-templated transcription, initiation
HD73_RS17420	COG0768	penicillin binding
HD73_RS17430	COG2239	Acts as a magnesium transporter
HD73_RS17435	COG0772	Belongs to the SEDS family
HD73_RS17460	COG0076	glutamate decarboxylase activity
HD73_RS17470	COG1533	DNA photolyase activity
HD73_RS17495	COG3344	reverse transcriptase
HD73_RS17515	COG1760	l-serine dehydratase
HD73_RS17520	COG1760	l-serine dehydratase
HD73_RS17550	COG0367	asparagine synthase
HD73_RS17555	COG1309	transcriptional regulator
HD73_RS17575	COG1396	sequence-specific DNA binding
HD73_RS17680	COG5444	nuclease activity
HD73_RS17705	COG1876	peptidase activity
HD73_RS17710	COG2843	Capsule synthesis protein
HD73_RS17720	COG0477	Major facilitator Superfamily
HD73_RS17735	COG1846	Transcriptional regulator
HD73_RS17740	COG2814	Major facilitator Superfamily
HD73_RS17755	COG2031	fatty acid transporter
HD73_RS17765	COG2249	NAD(P)H dehydrogenase (quinone) activity
HD73_RS17820	COG1288	antiporter activity
HD73_RS17835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HD73_RS17845	COG1733	regulation of RNA biosynthetic process
HD73_RS17850	COG0778	Nitroreductase
HD73_RS17860	COG0469	pyruvate kinase activity
HD73_RS17880	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS17890	COG1131	(ABC) transporter
HD73_RS17915	COG1011	Hydrolase
HD73_RS17925	COG2365	Tyrosine phosphatase family
HD73_RS17960	COG0628	permease
HD73_RS17985	COG0500	methyltransferase
HD73_RS17995	COG0477	Major facilitator Superfamily
HD73_RS18025	COG1253	flavin adenine dinucleotide binding
HD73_RS18040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HD73_RS18070	COG0697	spore germination
HD73_RS18080	COG1357	PFAM Pentapeptide repeats (8 copies)
HD73_RS18085	COG3813	Protein conserved in bacteria
HD73_RS18090	COG2706	6-phosphogluconolactonase activity
HD73_RS18095	COG1070	Carbohydrate kinase
HD73_RS18105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HD73_RS18110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HD73_RS18115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HD73_RS18120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HD73_RS18150	COG0840	transmembrane signaling receptor activity
HD73_RS18160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HD73_RS18160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HD73_RS18165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HD73_RS18165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HD73_RS18170	COG1733	regulation of RNA biosynthetic process
HD73_RS18185	COG0814	amino acid
HD73_RS18210	COG2188	Transcriptional regulator
HD73_RS18215	COG0673	inositol 2-dehydrogenase activity
HD73_RS18235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS18255	COG0384	phenazine biosynthesis protein PhzF
HD73_RS18275	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS18280	COG2249	NAD(P)H dehydrogenase (quinone) activity
HD73_RS18285	COG1733	regulation of RNA biosynthetic process
HD73_RS18310	COG1191	sigma factor activity
HD73_RS18365	COG1151	hydroxylamine reductase activity
HD73_RS18420	COG1113	amino acid transport
HD73_RS18425	COG2814	Major facilitator Superfamily
HD73_RS18455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HD73_RS18460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HD73_RS18470	COG1247	-acetyltransferase
HD73_RS18475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS18480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS18485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS18490	COG3739	integral membrane protein
HD73_RS18510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS18525	COG0583	DNA-binding transcription factor activity
HD73_RS18535	COG2890	protein-(glutamine-N5) methyltransferase activity
HD73_RS18550	COG1193	negative regulation of DNA recombination
HD73_RS18560	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HD73_RS18565	COG1164	Oligoendopeptidase f
HD73_RS18595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HD73_RS18620	COG0584	glycerophosphoryl diester phosphodiesterase
HD73_RS18635	COG0640	Transcriptional regulator
HD73_RS18640	COG0604	alcohol dehydrogenase
HD73_RS18655	COG0457	Tetratricopeptide repeat
HD73_RS18665	COG0385	Bile acid
HD73_RS18670	COG0277	FAD linked oxidase domain protein
HD73_RS18695	COG1183	phosphatidylcholine synthase activity
HD73_RS18705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS18705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD73_RS18710	COG1252	NADH dehydrogenase
HD73_RS18720	COG0823	Involved in the tonB-independent uptake of proteins
HD73_RS18725	COG3397	chitin binding
HD73_RS18735	COG0697	spore germination
HD73_RS18765	COG3344	reverse transcriptase
HD73_RS18790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HD73_RS18800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HD73_RS18810	COG0457	Tetratricopeptide repeat
HD73_RS18845	COG1404	Belongs to the peptidase S8 family
HD73_RS18890	COG0488	(ABC) transporter
HD73_RS18915	COG3852	Histidine kinase
HD73_RS18925	COG1285	pathogenesis
HD73_RS18935	COG2514	catechol 2,3-dioxygenase activity
HD73_RS18940	COG2720	vancomycin resistance protein
HD73_RS18980	COG0716	FMN binding
HD73_RS19015	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS19025	COG0165	Argininosuccinate lyase
HD73_RS19040	COG4145	pantothenate transmembrane transporter activity
HD73_RS19050	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS19055	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS19065	COG1657	PFAM Prenyltransferase squalene oxidase
HD73_RS19070	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HD73_RS19075	COG2962	Rard protein
HD73_RS19080	COG3326	Membrane
HD73_RS19095	COG0489	protein tyrosine kinase activity
HD73_RS19105	COG0314	molybdopterin synthase activity
HD73_RS19110	COG0303	'Molybdopterin
HD73_RS19115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HD73_RS19120	COG2116	formate transmembrane transporter activity
HD73_RS19130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HD73_RS19135	COG5609	conserved protein (DUF2294)
HD73_RS19140	COG2427	Protein of unknown function (DUF1641)
HD73_RS19145	COG3383	formate dehydrogenase (NAD+) activity
HD73_RS19155	COG0697	spore germination
HD73_RS19170	COG0531	amino acid
HD73_RS19205	COG2226	methyltransferase
HD73_RS19210	COG4166	transmembrane transport
HD73_RS19215	COG4166	transmembrane transport
HD73_RS19220	COG4166	transmembrane transport
HD73_RS19225	COG1316	TRANSCRIPTIONal
HD73_RS19235	COG1595	DNA-templated transcription, initiation
HD73_RS19245	COG1131	(ABC) transporter
HD73_RS19265	COG0673	inositol 2-dehydrogenase activity
HD73_RS19270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD73_RS19275	COG0187	DNA topoisomerase II activity
HD73_RS19285	COG1832	CoA-binding protein
HD73_RS19290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HD73_RS19295	COG0745	RESPONSE REGULATOR receiver
HD73_RS19305	COG1328	CTP reductase activity
HD73_RS19305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HD73_RS19315	COG4841	protein insertion into membrane
HD73_RS19320	COG0824	Thioesterase
HD73_RS19355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD73_RS19370	COG1132	(ABC) transporter
HD73_RS19375	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HD73_RS19405	COG2211	Major facilitator Superfamily
HD73_RS19415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HD73_RS19430	COG0183	Belongs to the thiolase family
HD73_RS19435	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS19440	COG1268	BioY protein
HD73_RS19445	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS19450	COG1396	sequence-specific DNA binding
HD73_RS19475	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HD73_RS19495	COG0830	nickel cation binding
HD73_RS19535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS19545	COG5002	protein histidine kinase activity
HD73_RS19550	COG0400	carboxylic ester hydrolase activity
HD73_RS19555	COG0346	lactoylglutathione lyase activity
HD73_RS19570	COG0069	glutamate synthase activity
HD73_RS19575	COG1902	pentaerythritol trinitrate reductase activity
HD73_RS19580	COG3344	reverse transcriptase
HD73_RS19590	COG1329	Transcriptional regulator
HD73_RS19595	COG0010	Belongs to the arginase family
HD73_RS19620	COG2226	methyltransferase
HD73_RS19650	COG4846	Membrane protein involved in cytochrome C biogenesis
HD73_RS19655	COG0785	Cytochrome C biogenesis protein
HD73_RS19665	COG1473	amidohydrolase
HD73_RS19670	COG2963	transposase activity
HD73_RS19675	COG2801	Transposase and inactivated derivatives
HD73_RS19685	COG1131	(ABC) transporter
HD73_RS19700	COG0583	DNA-binding transcription factor activity
HD73_RS19710	COG1346	cytolysis
HD73_RS19725	COG0730	response to heat
HD73_RS19750	COG1132	(ABC) transporter
HD73_RS19755	COG1132	(ABC) transporter
HD73_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD73_RS19795	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS19805	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS19815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HD73_RS19835	COG1695	Transcriptional regulator
HD73_RS19840	COG0174	glutamine synthetase
HD73_RS19845	COG0789	Transcriptional regulator
HD73_RS19850	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HD73_RS19855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HD73_RS19860	COG2860	membrane
HD73_RS19865	COG0464	growth
HD73_RS19895	COG1388	LysM domain
HD73_RS19895	COG3584	3D domain protein
HD73_RS19900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HD73_RS19900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HD73_RS19900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HD73_RS19905	COG1105	Belongs to the carbohydrate kinase PfkB family
HD73_RS19910	COG1349	DNA-binding transcription factor activity
HD73_RS19915	COG1979	alcohol dehydrogenase
HD73_RS19920	COG2322	membrane
HD73_RS19935	COG1113	amino acid transport
HD73_RS19945	COG1408	metallophosphoesterase
HD73_RS19950	COG2116	formate transmembrane transporter activity
HD73_RS19965	COG2217	Heavy metal translocating P-type atpase
HD73_RS19970	COG2608	mercury ion transmembrane transporter activity
HD73_RS19975	COG1937	Protein conserved in bacteria
HD73_RS19985	COG2819	hydrolase of the alpha beta superfamily
HD73_RS19990	COG1120	ATPase activity
HD73_RS19995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS20000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS20005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS20010	COG2169	Transcriptional regulator
HD73_RS20015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HD73_RS20020	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HD73_RS20040	COG2267	carboxylic ester hydrolase activity
HD73_RS20045	COG3300	MHYT domain
HD73_RS20045	COG5001	Diguanylate cyclase
HD73_RS20065	COG1086	Polysaccharide biosynthesis protein
HD73_RS20085	COG1346	cytolysis
HD73_RS20095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HD73_RS20105	COG2188	Transcriptional regulator
HD73_RS20110	COG2723	6-phospho-beta-galactosidase activity
HD73_RS20115	COG0823	Involved in the tonB-independent uptake of proteins
HD73_RS20120	COG1404	Belongs to the peptidase S8 family
HD73_RS20125	COG3773	Cell wall hydrolase
HD73_RS20135	COG1368	sulfuric ester hydrolase activity
HD73_RS20140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HD73_RS20165	COG4550	Control of competence regulator ComK, YlbF/YmcA
HD73_RS20175	COG1013	pyruvate-flavodoxin oxidoreductase activity
HD73_RS20180	COG0674	pyruvate-flavodoxin oxidoreductase activity
HD73_RS20180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HD73_RS20190	COG2359	stage V sporulation protein S
HD73_RS20195	COG1692	metallophosphoesterase
HD73_RS20215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HD73_RS20220	COG1426	Protein conserved in bacteria
HD73_RS20235	COG0300	oxidoreductase activity
HD73_RS20240	COG0612	Peptidase, M16
HD73_RS20245	COG0612	Peptidase, M16
HD73_RS20250	COG1079	Belongs to the binding-protein-dependent transport system permease family
HD73_RS20255	COG4603	Belongs to the binding-protein-dependent transport system permease family
HD73_RS20260	COG3845	ABC transporter
HD73_RS20265	COG1744	ABC transporter substrate-binding protein PnrA-like
HD73_RS20270	COG2188	Transcriptional regulator
HD73_RS20285	COG0740	serine-type endopeptidase activity
HD73_RS20290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HD73_RS20305	COG0527	aspartate kinase activity
HD73_RS20310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HD73_RS20315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HD73_RS20320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HD73_RS20325	COG1873	PFAM PRC-barrel domain
HD73_RS20330	COG0612	Peptidase, M16
HD73_RS20335	COG0726	polysaccharide deacetylase
HD73_RS20350	COG0196	riboflavin kinase activity
HD73_RS20360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HD73_RS20365	COG1550	Protein conserved in bacteria
HD73_RS20375	COG1358	cellular component organization or biogenesis
HD73_RS20380	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HD73_RS20385	COG0195	Participates in both transcription termination and antitermination
HD73_RS20405	COG0750	zinc metalloprotease
HD73_RS20415	COG4589	Belongs to the CDS family
HD73_RS20460	COG4974	Belongs to the 'phage' integrase family
HD73_RS20470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HD73_RS20475	COG0758	DNA mediated transformation
HD73_RS20480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HD73_RS20520	COG1837	Belongs to the UPF0109 family
HD73_RS20530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HD73_RS20540	COG0552	protein localization to endoplasmic reticulum
HD73_RS20545	COG1196	nuclear chromosome segregation
HD73_RS20550	COG3344	reverse transcriptase
HD73_RS20555	COG1196	nuclear chromosome segregation
HD73_RS20565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HD73_RS20570	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS20575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HD73_RS20590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HD73_RS20595	COG1461	Dihydroxyacetone kinase
HD73_RS20600	COG1302	Protein conserved in bacteria
HD73_RS20615	COG1564	THIamine pyrophosphokinase
HD73_RS20620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HD73_RS20630	COG0515	serine threonine protein kinase
HD73_RS20630	COG2815	serine threonine protein kinase
HD73_RS20635	COG0631	protein serine/threonine phosphatase activity
HD73_RS20645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HD73_RS20645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HD73_RS20660	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HD73_RS20665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HD73_RS20685	COG1561	YicC-like family, N-terminal region
HD73_RS20690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HD73_RS20700	COG0006	proline dipeptidase activity
HD73_RS20715	COG3069	C4-dicarboxylate transmembrane transporter activity
HD73_RS20775	COG0564	pseudouridine synthase activity
HD73_RS20795	COG3599	regulation of cell shape
HD73_RS20800	COG2302	S4 RNA-binding domain
HD73_RS20805	COG0762	integral membrane protein
HD73_RS20815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HD73_RS20825	COG1873	PFAM PRC-barrel domain
HD73_RS20830	COG1191	sigma factor activity
HD73_RS20835	COG1191	sigma factor activity
HD73_RS20845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HD73_RS20850	COG0849	cell division
HD73_RS20870	COG0772	Belongs to the SEDS family
HD73_RS20890	COG0768	penicillin binding
HD73_RS20895	COG0768	penicillin binding
HD73_RS20915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HD73_RS20930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HD73_RS20935	COG1399	metal-binding, possibly nucleic acid-binding protein
HD73_RS20945	COG3480	Lon protease (S16) C-terminal proteolytic domain
HD73_RS20950	COG1752	Esterase of the alpha-beta hydrolase superfamily
HD73_RS20955	COG3314	Sporulation integral membrane protein YlbJ
HD73_RS20965	COG0742	ribosomal rna small subunit methyltransferase
HD73_RS20980	COG3679	Belongs to the UPF0342 family
HD73_RS20985	COG0406	alpha-ribazole phosphatase activity
HD73_RS21000	COG2340	Cysteine-rich secretory protein family
HD73_RS21015	COG3336	cytochrome c oxidase
HD73_RS21050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HD73_RS21055	COG0772	Belongs to the SEDS family
HD73_RS21065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HD73_RS21070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HD73_RS21080	COG4896	Protein conserved in bacteria
HD73_RS21095	COG1217	gtp-binding protein TYPA
HD73_RS21105	COG0483	inositol monophosphate 1-phosphatase activity
HD73_RS21125	COG1982	Orn Lys Arg decarboxylase major
HD73_RS21170	COG0022	dehydrogenase e1 component
HD73_RS21175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HD73_RS21190	COG0561	phosphatase activity
HD73_RS21200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HD73_RS21205	COG0569	domain protein
HD73_RS21225	COG0583	DNA-binding transcription factor activity
HD73_RS21230	COG0517	IMP dehydrogenase activity
HD73_RS21240	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HD73_RS21250	COG4703	Protein of unknown function (DUF1797)
HD73_RS21265	COG2200	EAL domain
HD73_RS21270	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS21275	COG1408	metallophosphoesterase
HD73_RS21320	COG2814	Major facilitator Superfamily
HD73_RS21345	COG3209	COG3209 Rhs family protein
HD73_RS21355	COG2205	protein histidine kinase activity
HD73_RS21365	COG0436	Aminotransferase
HD73_RS21370	COG1609	Transcriptional regulator
HD73_RS21375	COG3833	ABC-type maltose transport systems, permease component
HD73_RS21380	COG1175	transmembrane transport
HD73_RS21385	COG2182	Extracellular solute-binding protein
HD73_RS21395	COG0366	Alpha amylase catalytic
HD73_RS21400	COG3842	ATPase activity
HD73_RS21435	COG0183	Belongs to the thiolase family
HD73_RS21470	COG1695	Transcriptional regulator
HD73_RS21475	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS21495	COG4974	Belongs to the 'phage' integrase family
HD73_RS21520	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS21525	COG0640	Transcriptional regulator
HD73_RS21555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HD73_RS21560	COG0436	Aminotransferase
HD73_RS21595	COG2084	Dehydrogenase
HD73_RS21605	COG2199	diguanylate cyclase activity
HD73_RS21610	COG0778	Nitroreductase
HD73_RS21635	COG2190	(PTS) system
HD73_RS21635	COG1263	PTS System
HD73_RS21635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HD73_RS21640	COG3711	transcriptional antiterminator
HD73_RS21650	COG2188	Transcriptional regulator
HD73_RS21660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HD73_RS21690	COG1547	Domain of unknown function (DUF309)
HD73_RS21695	COG0456	acetyltransferase
HD73_RS21705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HD73_RS21710	COG4086	secreted protein
HD73_RS21715	COG0561	phosphatase activity
HD73_RS21720	COG0697	spore germination
HD73_RS21735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HD73_RS21780	COG1686	Belongs to the peptidase S11 family
HD73_RS21785	COG1725	Transcriptional regulator
HD73_RS21790	COG1131	(ABC) transporter
HD73_RS21805	COG1846	Transcriptional regulator
HD73_RS21820	COG0598	Magnesium transport protein CorA
HD73_RS21845	COG4974	Belongs to the 'phage' integrase family
HD73_RS21855	COG0735	belongs to the Fur family
HD73_RS21860	COG1300	Membrane
HD73_RS21880	COG0667	Aldo Keto reductase
HD73_RS21885	COG0656	L-ascorbic acid biosynthetic process
HD73_RS21890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HD73_RS21890	COG0456	acetyltransferase
HD73_RS21900	COG4085	toxin activity
HD73_RS21900	COG1525	nuclease
HD73_RS21900	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS21910	COG0596	Alpha beta hydrolase
HD73_RS21915	COG2056	Na+-H+ antiporter family
HD73_RS21920	COG1609	Transcriptional regulator
HD73_RS21925	COG0456	acetyltransferase
HD73_RS21930	COG1073	alpha beta
HD73_RS21945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HD73_RS21945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HD73_RS21950	COG0307	riboflavin synthase, alpha
HD73_RS21980	COG1073	alpha beta
HD73_RS21980	COG2226	methyltransferase
HD73_RS21995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HD73_RS22005	COG1757	Na H antiporter
HD73_RS22010	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS22020	COG1522	sequence-specific DNA binding
HD73_RS22065	COG0300	oxidoreductase activity
HD73_RS22070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS22075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HD73_RS22080	COG1760	l-serine dehydratase
HD73_RS22085	COG1760	l-serine dehydratase
HD73_RS22115	COG1285	pathogenesis
HD73_RS22130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HD73_RS22135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS22150	COG1376	ErfK ybiS ycfS ynhG family protein
HD73_RS22155	COG4129	membrane
HD73_RS22160	COG1126	abc transporter atp-binding protein
HD73_RS22165	COG0765	amino acid transport
HD73_RS22170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HD73_RS22195	COG2323	membrane
HD73_RS22200	COG0772	Belongs to the SEDS family
HD73_RS22210	COG0508	dehydrogenase complex catalyzes the overall conversion of
HD73_RS22215	COG0022	dehydrogenase e1 component
HD73_RS22220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HD73_RS22225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HD73_RS22240	COG0280	phosphate acetyltransferase
HD73_RS22250	COG3829	transcription factor binding
HD73_RS22250	COG3290	protein histidine kinase activity
HD73_RS22260	COG0584	glycerophosphoryl diester phosphodiesterase
HD73_RS22265	COG3093	addiction module antidote protein HigA
HD73_RS22285	COG0750	zinc metalloprotease
HD73_RS22290	COG0497	DNA recombination
HD73_RS22300	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HD73_RS22310	COG0142	geranyltranstransferase activity
HD73_RS22335	COG1302	Protein conserved in bacteria
HD73_RS22340	COG0439	Biotin carboxylase
HD73_RS22345	COG0511	ligase activity, forming carbon-carbon bonds
HD73_RS22390	COG3854	ATPases associated with a variety of cellular activities
HD73_RS22415	COG0006	proline dipeptidase activity
HD73_RS22430	COG3872	metal-dependent enzyme
HD73_RS22440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HD73_RS22475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD73_RS22485	COG1609	Transcriptional regulator
HD73_RS22495	COG2076	Multidrug Resistance protein
HD73_RS22500	COG2076	Multidrug Resistance protein
HD73_RS22540	COG1725	Transcriptional regulator
HD73_RS22570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HD73_RS22635	COG1459	type II secretion system
HD73_RS22640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HD73_RS22695	COG0646	methionine synthase
HD73_RS22695	COG1410	methionine synthase
HD73_RS22700	COG0646	methionine synthase
HD73_RS22700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HD73_RS22710	COG0626	cystathionine gamma-synthase activity
HD73_RS22715	COG0626	cystathionine gamma-synthase activity
HD73_RS22735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS22745	COG1940	carbohydrate kinase activity
HD73_RS22750	COG4483	Protein conserved in bacteria
HD73_RS22755	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HD73_RS22760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HD73_RS22770	COG0704	Plays a role in the regulation of phosphate uptake
HD73_RS22780	COG0573	inorganic phosphate transmembrane transporter activity
HD73_RS22785	COG0573	inorganic phosphate transmembrane transporter activity
HD73_RS22790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HD73_RS22795	COG0768	penicillin binding
HD73_RS22800	COG0477	Major facilitator Superfamily
HD73_RS22805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HD73_RS22815	COG5521	maltodextrose utilization protein MalA
HD73_RS22830	COG0735	belongs to the Fur family
HD73_RS22835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HD73_RS22840	COG1121	(ABC) transporter
HD73_RS22845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS22875	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HD73_RS22880	COG2384	SAM-dependent methyltransferase
HD73_RS22890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HD73_RS22895	COG0358	DNA primase activity
HD73_RS22910	COG0517	IMP dehydrogenase activity
HD73_RS22925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HD73_RS22930	COG0295	cytidine deaminase activity
HD73_RS22935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HD73_RS22945	COG1480	7TM receptor with intracellular HD hydrolase
HD73_RS22950	COG1702	phosphate starvation-inducible protein PhoH
HD73_RS22975	COG1610	YqeY-like protein
HD73_RS22980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HD73_RS22985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HD73_RS22990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HD73_RS23020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HD73_RS23025	COG1733	regulation of RNA biosynthetic process
HD73_RS23050	COG1466	dna polymerase III delta subunit
HD73_RS23060	COG0658	competence protein
HD73_RS23060	COG2333	competence protein COMEC
HD73_RS23065	COG2131	deaminase
HD73_RS23070	COG1596	polysaccharide export
HD73_RS23070	COG1555	photosystem II stabilization
HD73_RS23075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HD73_RS23080	COG2226	methyltransferase
HD73_RS23085	COG0799	negative regulation of ribosome biogenesis
HD73_RS23090	COG1713	HD superfamily hydrolase involved in NAD metabolism
HD73_RS23100	COG1534	Rna-binding protein
HD73_RS23110	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HD73_RS23115	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HD73_RS23140	COG1595	DNA-templated transcription, initiation
HD73_RS23150	COG0778	Nitroreductase
HD73_RS23155	COG2357	RelA SpoT domain protein
HD73_RS23165	COG1785	Belongs to the alkaline phosphatase family
HD73_RS23175	COG2267	carboxylic ester hydrolase activity
HD73_RS23225	COG3186	Phenylalanine-4-hydroxylase
HD73_RS23235	COG2514	catechol 2,3-dioxygenase activity
HD73_RS23240	COG2259	Doxx family
HD73_RS23280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS23290	COG1454	alcohol dehydrogenase
HD73_RS23290	COG1012	belongs to the aldehyde dehydrogenase family
HD73_RS23295	COG0626	cystathionine gamma-synthase activity
HD73_RS23300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HD73_RS23325	COG0768	penicillin binding
HD73_RS23345	COG0826	peptidase U32
HD73_RS23350	COG0826	peptidase U32
HD73_RS23355	COG4122	O-methyltransferase activity
HD73_RS23360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HD73_RS23390	COG0628	permease
HD73_RS23410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HD73_RS23425	COG1104	cysteine desulfurase activity
HD73_RS23430	COG1959	2 iron, 2 sulfur cluster binding
HD73_RS23435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HD73_RS23450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HD73_RS23475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HD73_RS23485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HD73_RS23485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HD73_RS23490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HD73_RS23495	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HD73_RS23495	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HD73_RS23505	COG2244	polysaccharide biosynthetic process
HD73_RS23510	COG2323	membrane
HD73_RS23520	COG1862	Preprotein translocase
HD73_RS23550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HD73_RS23580	COG0157	Belongs to the NadC ModD family
HD73_RS23585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HD73_RS23590	COG1104	cysteine desulfurase activity
HD73_RS23595	COG1827	regulation of RNA biosynthetic process
HD73_RS23600	COG2258	MOSC domain
HD73_RS23605	COG0077	Prephenate dehydratase
HD73_RS23610	COG0577	efflux transmembrane transporter activity
HD73_RS23615	COG0577	efflux transmembrane transporter activity
HD73_RS23620	COG1136	(ABC) transporter
HD73_RS23625	COG5002	protein histidine kinase activity
HD73_RS23630	COG0745	RESPONSE REGULATOR receiver
HD73_RS23640	COG3290	protein histidine kinase activity
HD73_RS23650	COG2868	ribosomal protein
HD73_RS23660	COG1530	ribonuclease E activity
HD73_RS23665	COG1994	Peptidase M50
HD73_RS23670	COG0739	heme binding
HD73_RS23675	COG2894	cell division
HD73_RS23695	COG1077	Cell shape determining protein MreB Mrl
HD73_RS23715	COG0285	dihydrofolate synthase activity
HD73_RS23730	COG1388	LysM domain
HD73_RS23740	COG0113	porphobilinogen synthase activity
HD73_RS23745	COG1587	Uroporphyrinogen-III synthase
HD73_RS23755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HD73_RS23765	COG1846	Transcriptional regulator
HD73_RS23770	COG1764	response to oxidative stress
HD73_RS23785	COG1067	ATP-dependent peptidase activity
HD73_RS23785	COG0470	DNA polymerase III
HD73_RS23835	COG0622	Phosphoesterase
HD73_RS23850	COG5401	PFAM Sporulation and spore germination
HD73_RS23870	COG2197	response regulator
HD73_RS23875	COG2233	PERMEase
HD73_RS23880	COG0402	S-adenosylhomocysteine deaminase activity
HD73_RS23885	COG1983	PspC domain protein
HD73_RS23890	COG1396	sequence-specific DNA binding
HD73_RS23895	COG0697	spore germination
HD73_RS23905	COG1959	2 iron, 2 sulfur cluster binding
HD73_RS23910	COG1668	transmembrane transport
HD73_RS23915	COG4152	abc transporter atp-binding protein
HD73_RS23920	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HD73_RS23925	COG1360	Flagellar Motor Protein
HD73_RS23930	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HD73_RS23935	COG1876	peptidase activity
HD73_RS23940	COG0824	Thioesterase
HD73_RS23945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HD73_RS23950	COG1053	succinate dehydrogenase
HD73_RS23955	COG2009	succinate dehydrogenase
HD73_RS23960	COG1719	4-vinyl reductase, 4VR
HD73_RS23970	COG3118	belongs to the thioredoxin family
HD73_RS23975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HD73_RS23980	COG2086	electron transfer activity
HD73_RS23985	COG1024	Enoyl-CoA hydratase
HD73_RS23990	COG1309	transcriptional regulator
HD73_RS23995	COG0318	PFAM AMP-dependent synthetase and ligase
HD73_RS24020	COG2318	DinB family
HD73_RS24050	COG1131	(ABC) transporter
HD73_RS24055	COG2205	protein histidine kinase activity
HD73_RS24060	COG0745	RESPONSE REGULATOR receiver
HD73_RS24070	COG4895	conserved protein (DUF2196)
HD73_RS24075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HD73_RS24085	COG4509	Sortase family
HD73_RS24090	COG1120	ATPase activity
HD73_RS24105	COG5386	Cell surface protein
HD73_RS24115	COG5386	Cell surface protein
HD73_RS24120	COG1114	Component of the transport system for branched-chain amino acids
HD73_RS24125	COG1187	pseudouridine synthase activity
HD73_RS24140	COG1796	DNA polymerase
HD73_RS24140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HD73_RS24145	COG1286	toxin biosynthetic process
HD73_RS24190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HD73_RS24200	COG1418	mRNA catabolic process
HD73_RS24220	COG2814	Major facilitator Superfamily
HD73_RS24225	COG1566	PFAM secretion protein HlyD family protein
HD73_RS24230	COG1309	transcriptional regulator
HD73_RS24235	COG1363	Peptidase, m42
HD73_RS24260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HD73_RS24275	COG1484	DNA-dependent DNA replication
HD73_RS24280	COG3611	Membrane attachment protein
HD73_RS24290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HD73_RS24295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HD73_RS24305	COG1971	Probably functions as a manganese efflux pump
HD73_RS24315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HD73_RS24315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HD73_RS24320	COG5002	protein histidine kinase activity
HD73_RS24325	COG0745	RESPONSE REGULATOR receiver
HD73_RS24345	COG0538	isocitrate dehydrogenase activity
HD73_RS24350	COG0372	Belongs to the citrate synthase family
HD73_RS24365	COG0628	permease
HD73_RS24370	COG3030	protein affecting phage T7 exclusion by the F plasmid
HD73_RS24395	COG1725	Transcriptional regulator
HD73_RS24400	COG0281	malic enzyme
HD73_RS24405	COG0587	DNA-directed DNA polymerase activity
HD73_RS24420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HD73_RS24435	COG4109	DRTGG domain
HD73_RS24450	COG0006	proline dipeptidase activity
HD73_RS24485	COG0662	Cupin 2, conserved barrel domain protein
HD73_RS24500	COG1028	Short-chain dehydrogenase reductase Sdr
HD73_RS24505	COG0589	response to stress
HD73_RS24550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS24575	COG0827	DNA restriction-modification system
HD73_RS24580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HD73_RS24585	COG3874	Sporulation protein YtfJ
HD73_RS24600	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HD73_RS24610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HD73_RS24625	COG1104	cysteine desulfurase activity
HD73_RS24635	COG0583	DNA-binding transcription factor activity
HD73_RS24640	COG0697	spore germination
HD73_RS24645	COG1309	transcriptional regulator
HD73_RS24650	COG1956	GAF domain-containing protein
HD73_RS24655	COG0626	cystathionine gamma-synthase activity
HD73_RS24695	COG1595	DNA-templated transcription, initiation
HD73_RS24705	COG0110	maltose O-acetyltransferase activity
HD73_RS24710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HD73_RS24715	COG0454	-acetyltransferase
HD73_RS24720	COG0517	IMP dehydrogenase activity
HD73_RS24725	COG0123	including yeast histone deacetylase and acetoin utilization protein
HD73_RS24740	COG0745	RESPONSE REGULATOR receiver
HD73_RS24750	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS24755	COG0666	response to abiotic stimulus
HD73_RS24760	COG0745	RESPONSE REGULATOR receiver
HD73_RS24760	COG2972	Histidine kinase
HD73_RS24780	COG3279	Response regulator of the LytR AlgR family
HD73_RS24825	COG1605	Chorismate mutase
HD73_RS24825	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HD73_RS24830	COG4851	CamS sex pheromone cAM373 precursor
HD73_RS24835	COG3118	belongs to the thioredoxin family
HD73_RS24845	COG2309	aminopeptidase activity
HD73_RS24860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS24875	COG1674	ftsk spoiiie
HD73_RS24890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HD73_RS24900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD73_RS24905	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HD73_RS24910	COG1363	Peptidase, m42
HD73_RS24920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS24935	COG0510	thiamine kinase activity
HD73_RS24940	COG1523	belongs to the glycosyl hydrolase 13 family
HD73_RS24955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HD73_RS24960	COG1349	DNA-binding transcription factor activity
HD73_RS24965	COG1187	pseudouridine synthase activity
HD73_RS24970	COG2244	polysaccharide biosynthetic process
HD73_RS24975	COG2081	HI0933 family
HD73_RS24980	COG2814	Major facilitator Superfamily
HD73_RS24990	COG3832	glyoxalase III activity
HD73_RS25010	COG1329	Transcriptional regulator
HD73_RS25035	COG0314	molybdopterin synthase activity
HD73_RS25040	COG1763	Mo-molybdopterin cofactor biosynthetic process
HD73_RS25045	COG0303	'Molybdopterin
HD73_RS25055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HD73_RS25060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HD73_RS25080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HD73_RS25090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HD73_RS25140	COG2814	Major facilitator Superfamily
HD73_RS25145	COG0475	glutathione-regulated potassium exporter activity
HD73_RS25150	COG0490	domain, Protein
HD73_RS25155	COG0582	viral genome integration into host DNA
HD73_RS25165	COG1136	(ABC) transporter
HD73_RS25185	COG1242	4 iron, 4 sulfur cluster binding
HD73_RS25190	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HD73_RS25195	COG1794	racemase activity, acting on amino acids and derivatives
HD73_RS25215	COG2267	carboxylic ester hydrolase activity
HD73_RS25220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HD73_RS25225	COG0671	phosphoesterase, PA-phosphatase related
HD73_RS25230	COG0438	transferase activity, transferring glycosyl groups
HD73_RS25255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS25300	COG0546	phosphoglycolate phosphatase activity
HD73_RS25305	COG1349	DNA-binding transcription factor activity
HD73_RS25315	COG5002	protein histidine kinase activity
HD73_RS25320	COG3852	Histidine kinase
HD73_RS25325	COG2267	carboxylic ester hydrolase activity
HD73_RS25330	COG1368	sulfuric ester hydrolase activity
HD73_RS25350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HD73_RS25355	COG1116	anion transmembrane transporter activity
HD73_RS25360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HD73_RS25380	COG0494	nUDIX hydrolase
HD73_RS25410	COG1854	S-ribosylhomocysteine lyase activity
HD73_RS25420	COG0288	reversible hydration of carbon dioxide
HD73_RS25425	COG1271	oxidase subunit
HD73_RS25430	COG1294	oxidase, subunit
HD73_RS25445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS25465	COG1842	Phage shock protein A
HD73_RS25495	COG5002	protein histidine kinase activity
HD73_RS25500	COG0745	RESPONSE REGULATOR receiver
HD73_RS25525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HD73_RS25530	COG1597	lipid kinase activity
HD73_RS25560	COG0586	Pfam SNARE associated Golgi protein
HD73_RS25570	COG0577	efflux transmembrane transporter activity
HD73_RS25575	COG1136	(ABC) transporter
HD73_RS25580	COG2207	Transcriptional regulator
HD73_RS25580	COG3708	Transcriptional regulator
HD73_RS25590	COG5658	integral membrane protein
HD73_RS25595	COG0640	Transcriptional regulator
HD73_RS25600	COG0745	RESPONSE REGULATOR receiver
HD73_RS25605	COG2205	protein histidine kinase activity
HD73_RS25610	COG0577	efflux transmembrane transporter activity
HD73_RS25615	COG0577	efflux transmembrane transporter activity
HD73_RS25620	COG1136	(ABC) transporter
HD73_RS25625	COG0577	efflux transmembrane transporter activity
HD73_RS25655	COG2801	Transposase and inactivated derivatives
HD73_RS25660	COG2188	Transcriptional regulator
HD73_RS25680	COG3964	amidohydrolase
HD73_RS25700	COG4948	Mandelate Racemase Muconate Lactonizing
HD73_RS25720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HD73_RS25725	COG0596	Alpha beta hydrolase
HD73_RS25735	COG1169	isochorismate synthase
HD73_RS25740	COG1575	Belongs to the MenA family. Type 1 subfamily
HD73_RS25745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HD73_RS25780	COG0058	SHG alpha-glucan phosphorylase activity
HD73_RS25790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HD73_RS25910	COG0544	peptidyl-prolyl cis-trans isomerase activity
HD73_RS25945	COG1285	pathogenesis
HD73_RS25950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HD73_RS25970	COG2155	Conserved Protein
HD73_RS25975	COG1098	S1 RNA binding domain
HD73_RS25980	COG0436	Aminotransferase
HD73_RS25985	COG1522	sequence-specific DNA binding
HD73_RS25990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HD73_RS25995	COG2267	carboxylic ester hydrolase activity
HD73_RS26005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HD73_RS26025	COG5018	Exonuclease
HD73_RS26030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HD73_RS26055	COG2801	Transposase and inactivated derivatives
HD73_RS26060	COG2050	protein possibly involved in aromatic compounds catabolism
HD73_RS26070	COG1268	BioY protein
HD73_RS26075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HD73_RS26080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HD73_RS26095	COG3584	3D domain protein
HD73_RS26110	COG1252	NADH dehydrogenase
HD73_RS26125	COG3708	Transcriptional regulator
HD73_RS26140	COG1683	Conserved Protein
HD73_RS26205	COG1388	LysM domain
HD73_RS26205	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS26205	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS26210	COG4824	toxin secretion phage lysis holin
HD73_RS26270	COG0740	serine-type endopeptidase activity
HD73_RS26280	COG4626	Terminase
HD73_RS26280	COG1802	Transcriptional regulator
HD73_RS26330	COG0582	viral genome integration into host DNA
HD73_RS26420	COG1396	sequence-specific DNA binding
HD73_RS26455	COG2963	transposase activity
HD73_RS26460	COG2801	Transposase and inactivated derivatives
HD73_RS26465	COG0316	Belongs to the HesB IscA family
HD73_RS26480	COG1252	NADH dehydrogenase
HD73_RS26495	COG0390	transport system, permease component
HD73_RS26500	COG2824	Alkylphosphonate utilization operon protein PhnA
HD73_RS26545	COG4837	Protein of unknown function (DUF1462)
HD73_RS26550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HD73_RS26560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HD73_RS26565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HD73_RS26585	COG1358	cellular component organization or biogenesis
HD73_RS26595	COG2249	NAD(P)H dehydrogenase (quinone) activity
HD73_RS26600	COG0647	UMP catabolic process
HD73_RS26610	COG2445	Protein of unknown function DUF86
HD73_RS26615	COG1494	fructose-1,6-bisphosphatase
HD73_RS26640	COG4470	Protein conserved in bacteria
HD73_RS26650	COG0789	Transcriptional regulator
HD73_RS26655	COG4377	Putative membrane peptidase family (DUF2324)
HD73_RS26680	COG0739	heme binding
HD73_RS26690	COG3377	Domain of unknown function (DUF1805)
HD73_RS26695	COG0737	Belongs to the 5'-nucleotidase family
HD73_RS26700	COG0719	Fe-S assembly protein
HD73_RS26705	COG0822	iron-sulfur transferase activity
HD73_RS26710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HD73_RS26715	COG0719	Fe-S assembly protein
HD73_RS26720	COG0396	ATPase activity
HD73_RS26725	COG1464	Belongs to the NlpA lipoprotein family
HD73_RS26730	COG1464	Belongs to the NlpA lipoprotein family
HD73_RS26735	COG2011	ABC-type metal ion transport system permease component
HD73_RS26750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HD73_RS26755	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HD73_RS26765	COG1393	Belongs to the ArsC family
HD73_RS26785	COG0039	L-malate dehydrogenase activity
HD73_RS26800	COG1309	transcriptional regulator
HD73_RS26805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HD73_RS26810	COG1960	acyl-CoA dehydrogenase activity
HD73_RS26815	COG0183	Belongs to the thiolase family
HD73_RS26820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HD73_RS26820	COG1024	Enoyl-CoA hydratase
HD73_RS26830	COG1686	Belongs to the peptidase S11 family
HD73_RS26845	COG0011	TIGRFAM Protein of
HD73_RS26850	COG0840	transmembrane signaling receptor activity
HD73_RS26865	COG2814	Major facilitator Superfamily
HD73_RS26870	COG0531	amino acid
HD73_RS26890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HD73_RS26925	COG0586	Pfam SNARE associated Golgi protein
HD73_RS26935	COG1376	ErfK ybiS ycfS ynhG family protein
HD73_RS26940	COG0745	RESPONSE REGULATOR receiver
HD73_RS26945	COG5002	protein histidine kinase activity
HD73_RS26975	COG0840	transmembrane signaling receptor activity
HD73_RS26980	COG2151	metal-sulfur cluster biosynthetic enzyme
HD73_RS26985	COG3227	Zinc metalloprotease (Elastase)
HD73_RS27005	COG0586	Pfam SNARE associated Golgi protein
HD73_RS27010	COG0475	glutathione-regulated potassium exporter activity
HD73_RS27015	COG0490	domain, Protein
HD73_RS27025	COG1115	amino acid carrier protein
HD73_RS27030	COG0783	Belongs to the Dps family
HD73_RS27045	COG1611	Belongs to the LOG family
HD73_RS27055	COG1528	Iron-storage protein
HD73_RS27060	COG2311	Membrane
HD73_RS27065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS27070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS27075	COG1115	amino acid carrier protein
HD73_RS27080	COG1115	amino acid carrier protein
HD73_RS27085	COG2910	NAD(P)H-binding
HD73_RS27100	COG0656	L-ascorbic acid biosynthetic process
HD73_RS27105	COG2814	Major facilitator Superfamily
HD73_RS27110	COG1733	regulation of RNA biosynthetic process
HD73_RS27120	COG1252	NADH dehydrogenase
HD73_RS27175	COG0488	(ABC) transporter
HD73_RS27180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HD73_RS27230	COG0745	RESPONSE REGULATOR receiver
HD73_RS27245	COG3344	reverse transcriptase
HD73_RS27270	COG0557	exoribonuclease II activity
HD73_RS27275	COG1647	Serine aminopeptidase, S33
HD73_RS27280	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HD73_RS27285	COG1346	cytolysis
HD73_RS27320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HD73_RS27335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HD73_RS27365	COG0457	Tetratricopeptide repeat
HD73_RS27370	COG5632	N-Acetylmuramoyl-L-alanine amidase
HD73_RS27370	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS27370	COG1388	LysM domain
HD73_RS27375	COG4824	toxin secretion phage lysis holin
HD73_RS27380	COG3547	Transposase (IS116 IS110 IS902 family)
HD73_RS27515	COG3331	DNA recombination
HD73_RS27595	COG3646	Phage regulatory protein
HD73_RS27620	COG0582	viral genome integration into host DNA
HD73_RS27645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HD73_RS27660	COG2323	membrane
HD73_RS27670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HD73_RS27680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HD73_RS27690	COG1051	belongs to the nudix hydrolase family
HD73_RS27700	COG0492	ferredoxin-NADP+ reductase activity
HD73_RS27705	COG0457	Tetratricopeptide repeat
HD73_RS27710	COG0110	maltose O-acetyltransferase activity
HD73_RS27730	COG1950	PFAM Membrane protein of
HD73_RS27740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HD73_RS27745	COG0556	nucleotide-excision repair
HD73_RS27760	COG0789	Transcriptional regulator
HD73_RS27780	COG0583	DNA-binding transcription factor activity
HD73_RS27790	COG0655	NAD(P)H dehydrogenase (quinone) activity
HD73_RS27795	COG0488	(ABC) transporter
HD73_RS27805	COG1132	(ABC) transporter
HD73_RS27810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HD73_RS27815	COG3409	Peptidoglycan-binding domain 1 protein
HD73_RS27815	COG0793	Belongs to the peptidase S41A family
HD73_RS27820	COG2177	Part of the ABC transporter FtsEX involved in
HD73_RS27825	COG2884	Cell division ATP-binding protein ftsE
HD73_RS27840	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HD73_RS27855	COG1131	(ABC) transporter
HD73_RS27885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HD73_RS27890	COG1278	Cold shock
HD73_RS27895	COG1040	competence protein
HD73_RS27900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HD73_RS27905	COG1388	LysM domain
HD73_RS27905	COG0791	NLP P60 protein
HD73_RS27910	COG1733	regulation of RNA biosynthetic process
HD73_RS27915	COG1307	EDD domain protein, DegV family
HD73_RS27920	COG1739	Uncharacterized protein family UPF0029
HD73_RS27925	COG1316	TRANSCRIPTIONal
HD73_RS27930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HD73_RS27935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HD73_RS27940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HD73_RS27950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HD73_RS27950	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HD73_RS27970	COG1486	melibiose metabolic process
HD73_RS27975	COG1447	Phosphotransferase system cellobiose-specific component IIA
HD73_RS27980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HD73_RS27990	COG1447	Phosphotransferase system cellobiose-specific component IIA
HD73_RS28000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HD73_RS28005	COG1301	dicarboxylic acid transport
HD73_RS28020	COG1511	domain protein
HD73_RS28025	COG0583	DNA-binding transcription factor activity
HD73_RS28030	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HD73_RS28040	COG1271	oxidase subunit
HD73_RS28045	COG1294	oxidase, subunit
HD73_RS28050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HD73_RS28060	COG1620	l-lactate permease
HD73_RS28075	COG2389	metal-binding protein
HD73_RS28085	COG1368	sulfuric ester hydrolase activity
HD73_RS28095	COG1388	LysM domain
HD73_RS28095	COG0791	NLP P60 protein
HD73_RS28100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HD73_RS28110	COG1215	transferase activity, transferring glycosyl groups
HD73_RS28120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HD73_RS28125	COG3584	3D domain protein
HD73_RS28125	COG1388	LysM domain
HD73_RS28150	COG4715	Zinc finger, swim domain protein
HD73_RS28155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HD73_RS28195	COG0577	efflux transmembrane transporter activity
HD73_RS28200	COG1136	(ABC) transporter
HD73_RS28225	COG5002	protein histidine kinase activity
HD73_RS28230	COG0745	RESPONSE REGULATOR receiver
HD73_RS28240	COG1316	TRANSCRIPTIONal
HD73_RS28245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HD73_RS28250	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HD73_RS28255	COG1215	transferase activity, transferring glycosyl groups
HD73_RS28260	COG0463	Glycosyl transferase, family 2
HD73_RS28265	COG0438	transferase activity, transferring glycosyl groups
HD73_RS28275	COG1216	Glycosyl transferase, family 2
HD73_RS28290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HD73_RS28295	COG4464	protein tyrosine phosphatase activity
HD73_RS28300	COG0489	protein tyrosine kinase activity
HD73_RS28305	COG3944	biosynthesis protein
HD73_RS28310	COG0489	protein tyrosine kinase activity
HD73_RS28325	COG1609	Transcriptional regulator
HD73_RS28335	COG0739	heme binding
HD73_RS28350	COG3279	Response regulator of the LytR AlgR family
HD73_RS28355	COG2385	sporulation resulting in formation of a cellular spore
HD73_RS28370	COG4836	Membrane
HD73_RS28375	COG1007	ATP synthesis coupled electron transport
HD73_RS28380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HD73_RS28385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HD73_RS28395	COG0839	Belongs to the complex I subunit 6 family
HD73_RS28415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HD73_RS28480	COG0356	it plays a direct role in the translocation of protons across the membrane
HD73_RS28515	COG0698	ribose 5-phosphate isomerase
HD73_RS28530	COG2259	Doxx family
HD73_RS28535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HD73_RS28550	COG0009	L-threonylcarbamoyladenylate synthase
HD73_RS28585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HD73_RS28590	COG1494	fructose-1,6-bisphosphatase
HD73_RS28610	COG4821	SIS domain
HD73_RS28620	COG3343	RNA polymerase activity
HD73_RS28630	COG1960	acyl-CoA dehydrogenase activity
HD73_RS28635	COG1960	acyl-CoA dehydrogenase activity
HD73_RS28640	COG1250	3-hydroxyacyl-CoA dehydrogenase
HD73_RS28645	COG0183	Belongs to the thiolase family
HD73_RS28650	COG2181	nitrate reductase activity
HD73_RS28650	COG0247	lactate metabolic process
HD73_RS28655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HD73_RS28670	COG3344	reverse transcriptase
HD73_RS28690	COG5001	Diguanylate cyclase
HD73_RS28690	COG3300	MHYT domain
HD73_RS28705	COG3227	Zinc metalloprotease (Elastase)
HD73_RS28710	COG2197	response regulator
HD73_RS28715	COG4585	Histidine kinase
HD73_RS28720	COG0842	Transport permease protein
HD73_RS28725	COG1131	(ABC) transporter
HD73_RS28730	COG0024	Methionine aminopeptidase
HD73_RS28740	COG2234	aminopeptidase activity
HD73_RS28745	COG2801	Transposase and inactivated derivatives
HD73_RS28770	COG1595	DNA-templated transcription, initiation
HD73_RS28780	COG4506	Protein conserved in bacteria
HD73_RS28785	COG1619	proteins homologs of microcin C7 resistance protein MccF
HD73_RS28815	COG2814	Major facilitator Superfamily
HD73_RS28820	COG0789	Transcriptional regulator
HD73_RS28830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HD73_RS28840	COG1994	Peptidase M50
HD73_RS28850	COG1078	dGTPase activity
HD73_RS28855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HD73_RS28860	COG1120	ATPase activity
HD73_RS28865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS28870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HD73_RS28890	COG0280	phosphate acetyltransferase
HD73_RS28905	COG3773	Cell wall hydrolase
HD73_RS28915	COG2363	Small membrane protein
HD73_RS28925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HD73_RS28930	COG2233	PERMEase
HD73_RS28935	COG0561	phosphatase activity
HD73_RS28940	COG2814	Major facilitator Superfamily
HD73_RS28950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HD73_RS28955	COG1131	(ABC) transporter
HD73_RS28960	COG2755	lipolytic protein G-D-S-L family
HD73_RS28965	COG1609	Transcriptional regulator
HD73_RS28975	COG0460	homoserine dehydrogenase
HD73_RS28985	COG2873	o-acetylhomoserine
HD73_RS28995	COG1011	Hydrolase
HD73_RS29000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HD73_RS29010	COG2197	response regulator
HD73_RS29015	COG2203	Gaf domain
HD73_RS29015	COG4585	Histidine kinase
HD73_RS29020	COG0351	phosphomethylpyrimidine kinase
HD73_RS29025	COG3706	GGDEF domain
HD73_RS29030	COG2879	small protein
HD73_RS29035	COG1966	Carbon starvation protein
HD73_RS29040	COG3279	Response regulator of the LytR AlgR family
HD73_RS29045	COG0477	Major facilitator Superfamily
HD73_RS29055	COG0438	transferase activity, transferring glycosyl groups
HD73_RS29080	COG1607	acyl-coa hydrolase
HD73_RS29085	COG1216	Glycosyl transferase, family 2
HD73_RS29100	COG1216	Glycosyl transferase, family 2
HD73_RS29110	COG4485	Bacterial membrane protein, YfhO
HD73_RS29120	COG0488	(ABC) transporter
HD73_RS29125	COG1309	transcriptional regulator
HD73_RS29130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HD73_RS29135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HD73_RS29135	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HD73_RS29140	COG0628	permease
HD73_RS29160	COG3275	phosphorelay sensor kinase activity
HD73_RS29165	COG2814	Major facilitator Superfamily
HD73_RS29170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HD73_RS29175	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HD73_RS29195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HD73_RS29200	COG1272	protein, Hemolysin III
HD73_RS29220	COG3344	reverse transcriptase
HD73_RS29260	COG5002	protein histidine kinase activity
HD73_RS29275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HD73_RS29280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HD73_RS29285	COG4853	Protein conserved in bacteria
HD73_RS29295	COG5002	protein histidine kinase activity
HD73_RS29300	COG0745	RESPONSE REGULATOR receiver
HD73_RS29330	COG0305	Participates in initiation and elongation during chromosome replication
HD73_RS29340	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HD73_RS29345	COG4241	membrane
HD73_RS29365	COG0012	GTP binding
HD73_RS29370	COG4481	Protein conserved in bacteria
HD73_RS29375	COG0668	transmembrane transport
HD73_RS29385	COG1475	DNA binding
HD73_RS29390	COG1192	Involved in chromosome partitioning
HD73_RS29415	COG1847	R3H domain protein
HD73_RS29430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HD73_RS29670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD73_RS29675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD73_RS29685	COG2244	polysaccharide biosynthetic process
HD73_RS29790	COG0592	DNA-directed DNA polymerase activity
HD73_RS29950	COG1982	Orn Lys Arg decarboxylase major
HD73_RS30065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD73_RS30115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HD73_RS30155	COG2208	phosphoserine phosphatase activity
HD73_RS30535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HD73_RS30660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD73_RS30675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD73_RS30770	COG0592	DNA-directed DNA polymerase activity
HD73_RS30840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HD73_RS30855	COG2376	Dihydroxyacetone kinase