locus-tag	class	description
DF16_RS00015	COG0745	RESPONSE REGULATOR receiver
DF16_RS00020	COG2205	protein histidine kinase activity
DF16_RS00060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DF16_RS00085	COG5002	protein histidine kinase activity
DF16_RS00095	COG2252	PERMEase
DF16_RS00130	COG1388	LysM domain
DF16_RS00130	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS00130	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS00140	COG3344	reverse transcriptase
DF16_RS00260	COG3331	DNA recombination
DF16_RS00355	COG0582	viral genome integration into host DNA
DF16_RS00415	COG3378	Phage plasmid primase P4 family
DF16_RS00435	COG0582	viral genome integration into host DNA
DF16_RS00450	COG1266	CAAX protease self-immunity
DF16_RS00465	COG0488	(ABC) transporter
DF16_RS00475	COG0456	acetyltransferase
DF16_RS00480	COG1214	PFAM Peptidase M22, glycoprotease
DF16_RS00485	COG0802	atpase or kinase
DF16_RS00585	COG2183	response to ionizing radiation
DF16_RS00590	COG2337	Toxic component of a toxin-antitoxin (TA) module
DF16_RS00595	COG0864	Transcriptional regulator
DF16_RS00600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DF16_RS00605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DF16_RS00615	COG0705	Rhomboid family
DF16_RS00620	COG4294	response to UV
DF16_RS00630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DF16_RS00640	COG2814	Major facilitator Superfamily
DF16_RS00645	COG0531	amino acid
DF16_RS00655	COG0179	Fumarylacetoacetate (FAA) hydrolase
DF16_RS00660	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DF16_RS00690	COG0561	phosphatase activity
DF16_RS00700	COG2801	Transposase and inactivated derivatives
DF16_RS00705	COG4608	Belongs to the ABC transporter superfamily
DF16_RS00710	COG0444	Belongs to the ABC transporter superfamily
DF16_RS00715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF16_RS00720	COG0601	transmembrane transport
DF16_RS00730	COG3344	reverse transcriptase
DF16_RS00750	COG0747	negative chemotaxis
DF16_RS00760	COG0488	(ABC) transporter
DF16_RS00785	COG5298	Protein conserved in bacteria
DF16_RS00805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS00825	COG0204	Acyl-transferase
DF16_RS00840	COG0697	spore germination
DF16_RS00865	COG1910	domain protein
DF16_RS00870	COG0725	ABC transporter, periplasmic molybdate-binding protein
DF16_RS00875	COG4149	molybdate abc transporter
DF16_RS00895	COG0656	L-ascorbic acid biosynthetic process
DF16_RS00900	COG4166	transmembrane transport
DF16_RS00905	COG4166	transmembrane transport
DF16_RS00920	COG2207	Transcriptional regulator
DF16_RS00935	COG2814	Major facilitator Superfamily
DF16_RS00945	COG2271	Major facilitator Superfamily
DF16_RS00950	COG0277	FAD linked oxidase domain protein
DF16_RS00960	COG0604	alcohol dehydrogenase
DF16_RS00965	COG1464	Belongs to the NlpA lipoprotein family
DF16_RS00970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DF16_RS00975	COG2011	ABC-type metal ion transport system permease component
DF16_RS00980	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS01015	COG4856	YbbR-like protein
DF16_RS01020	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DF16_RS01100	COG0726	polysaccharide deacetylase
DF16_RS01105	COG2194	sulfuric ester hydrolase activity
DF16_RS01115	COG0489	protein tyrosine kinase activity
DF16_RS01145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DF16_RS01180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DF16_RS01190	COG0024	Methionine aminopeptidase
DF16_RS01200	COG0201	protein transport
DF16_RS01260	COG0255	Belongs to the universal ribosomal protein uL29 family
DF16_RS01325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DF16_RS01330	COG1358	cellular component organization or biogenesis
DF16_RS01345	COG2813	Specifically methylates the guanine in position
DF16_RS01365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DF16_RS01370	COG0250	Participates in transcription elongation, termination and antitermination
DF16_RS01375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DF16_RS01390	COG3688	RNA-binding protein containing a PIN domain
DF16_RS01395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF16_RS01410	COG1045	serine acetyltransferase
DF16_RS01430	COG4956	integral membrane protein (PIN domain superfamily)
DF16_RS01440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DF16_RS01445	COG0542	response to heat
DF16_RS01455	COG3880	PFAM UvrB UvrC protein
DF16_RS01545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DF16_RS01550	COG1396	sequence-specific DNA binding
DF16_RS01555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DF16_RS01560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DF16_RS01565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DF16_RS01570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF16_RS01575	COG0512	Glutamine amidotransferase of anthranilate synthase
DF16_RS01580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DF16_RS01585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DF16_RS01600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DF16_RS01605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DF16_RS01615	COG2208	phosphoserine phosphatase activity
DF16_RS01630	COG1098	S1 RNA binding domain
DF16_RS01650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DF16_RS01655	COG3956	TIGRFAM MazG family protein
DF16_RS01660	COG2244	polysaccharide biosynthetic process
DF16_RS01665	COG2002	toxin-antitoxin pair type II binding
DF16_RS01670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DF16_RS01690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DF16_RS01700	COG0251	oxidation-reduction process
DF16_RS01705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DF16_RS01720	COG4466	Protein conserved in bacteria
DF16_RS01740	COG0084	hydrolase, TatD family'
DF16_RS01750	COG2002	toxin-antitoxin pair type II binding
DF16_RS01755	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DF16_RS01765	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DF16_RS01775	COG1774	PSP1 C-terminal conserved region
DF16_RS01780	COG0470	DNA polymerase III
DF16_RS01790	COG1982	Orn Lys Arg decarboxylase major
DF16_RS01845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DF16_RS01850	COG0590	tRNA wobble adenosine to inosine editing
DF16_RS01860	COG1335	isochorismatase
DF16_RS01865	COG1428	Deoxynucleoside kinase
DF16_RS01870	COG1428	Deoxynucleoside kinase
DF16_RS01900	COG1686	Belongs to the peptidase S11 family
DF16_RS01905	COG0517	IMP dehydrogenase activity
DF16_RS01905	COG0516	GMP reductase activity
DF16_RS01940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DF16_RS01945	COG0187	DNA topoisomerase II activity
DF16_RS01955	COG2501	S4 domain
DF16_RS01960	COG0592	DNA-directed DNA polymerase activity
DF16_RS01970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DF16_RS01985	COG1847	R3H domain protein
DF16_RS02010	COG1192	Involved in chromosome partitioning
DF16_RS02015	COG1475	DNA binding
DF16_RS02025	COG0668	transmembrane transport
DF16_RS02030	COG4481	Protein conserved in bacteria
DF16_RS02035	COG0012	GTP binding
DF16_RS02055	COG4241	membrane
DF16_RS02060	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DF16_RS02070	COG0305	Participates in initiation and elongation during chromosome replication
DF16_RS02100	COG0745	RESPONSE REGULATOR receiver
DF16_RS02105	COG5002	protein histidine kinase activity
DF16_RS02115	COG4853	Protein conserved in bacteria
DF16_RS02120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DF16_RS02125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DF16_RS02140	COG5002	protein histidine kinase activity
DF16_RS02180	COG3344	reverse transcriptase
DF16_RS02200	COG1272	protein, Hemolysin III
DF16_RS02205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DF16_RS02225	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DF16_RS02230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DF16_RS02235	COG2814	Major facilitator Superfamily
DF16_RS02240	COG3275	phosphorelay sensor kinase activity
DF16_RS02260	COG0628	permease
DF16_RS02265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF16_RS02265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF16_RS02270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DF16_RS02275	COG1309	transcriptional regulator
DF16_RS02280	COG0488	(ABC) transporter
DF16_RS02285	COG0463	Glycosyl transferase, family 2
DF16_RS02290	COG4485	Bacterial membrane protein, YfhO
DF16_RS02300	COG1216	Glycosyl transferase, family 2
DF16_RS02315	COG1216	Glycosyl transferase, family 2
DF16_RS02320	COG1607	acyl-coa hydrolase
DF16_RS02330	COG0840	transmembrane signaling receptor activity
DF16_RS02345	COG0438	transferase activity, transferring glycosyl groups
DF16_RS02355	COG0477	Major facilitator Superfamily
DF16_RS02360	COG3279	Response regulator of the LytR AlgR family
DF16_RS02365	COG1966	Carbon starvation protein
DF16_RS02370	COG2879	small protein
DF16_RS02375	COG3706	GGDEF domain
DF16_RS02380	COG0351	phosphomethylpyrimidine kinase
DF16_RS02385	COG2203	Gaf domain
DF16_RS02385	COG4585	Histidine kinase
DF16_RS02390	COG2197	response regulator
DF16_RS02400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF16_RS02405	COG1011	Hydrolase
DF16_RS02415	COG2873	o-acetylhomoserine
DF16_RS02425	COG0460	homoserine dehydrogenase
DF16_RS02435	COG1609	Transcriptional regulator
DF16_RS02440	COG2755	lipolytic protein G-D-S-L family
DF16_RS02445	COG1131	(ABC) transporter
DF16_RS02450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DF16_RS02460	COG2814	Major facilitator Superfamily
DF16_RS02465	COG0561	phosphatase activity
DF16_RS02470	COG2233	PERMEase
DF16_RS02475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DF16_RS02485	COG2363	Small membrane protein
DF16_RS02495	COG3773	Cell wall hydrolase
DF16_RS02510	COG0280	phosphate acetyltransferase
DF16_RS02530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS02535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS02540	COG1120	ATPase activity
DF16_RS02545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS02550	COG1078	dGTPase activity
DF16_RS02560	COG1994	Peptidase M50
DF16_RS02570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF16_RS02575	COG0584	glycerophosphoryl diester phosphodiesterase
DF16_RS02580	COG0789	Transcriptional regulator
DF16_RS02585	COG2814	Major facilitator Superfamily
DF16_RS02615	COG1619	proteins homologs of microcin C7 resistance protein MccF
DF16_RS02620	COG4506	Protein conserved in bacteria
DF16_RS02630	COG1595	DNA-templated transcription, initiation
DF16_RS02655	COG2801	Transposase and inactivated derivatives
DF16_RS02660	COG2234	aminopeptidase activity
DF16_RS02670	COG0024	Methionine aminopeptidase
DF16_RS02675	COG1131	(ABC) transporter
DF16_RS02680	COG0842	Transport permease protein
DF16_RS02685	COG4585	Histidine kinase
DF16_RS02690	COG2197	response regulator
DF16_RS02695	COG3227	Zinc metalloprotease (Elastase)
DF16_RS02710	COG5001	Diguanylate cyclase
DF16_RS02710	COG3300	MHYT domain
DF16_RS02730	COG3344	reverse transcriptase
DF16_RS02745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF16_RS02750	COG2181	nitrate reductase activity
DF16_RS02750	COG0247	lactate metabolic process
DF16_RS02755	COG0183	Belongs to the thiolase family
DF16_RS02760	COG1250	3-hydroxyacyl-CoA dehydrogenase
DF16_RS02765	COG1960	acyl-CoA dehydrogenase activity
DF16_RS02770	COG1960	acyl-CoA dehydrogenase activity
DF16_RS02780	COG3343	RNA polymerase activity
DF16_RS02790	COG4821	SIS domain
DF16_RS02810	COG1494	fructose-1,6-bisphosphatase
DF16_RS02815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DF16_RS02850	COG0009	L-threonylcarbamoyladenylate synthase
DF16_RS02870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DF16_RS02875	COG2259	Doxx family
DF16_RS02890	COG0698	ribose 5-phosphate isomerase
DF16_RS02925	COG0356	it plays a direct role in the translocation of protons across the membrane
DF16_RS03015	COG0839	Belongs to the complex I subunit 6 family
DF16_RS03025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DF16_RS03030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DF16_RS03035	COG1007	ATP synthesis coupled electron transport
DF16_RS03040	COG4836	Membrane
DF16_RS03055	COG2385	sporulation resulting in formation of a cellular spore
DF16_RS03060	COG3279	Response regulator of the LytR AlgR family
DF16_RS03075	COG0739	heme binding
DF16_RS03085	COG1609	Transcriptional regulator
DF16_RS03100	COG0489	protein tyrosine kinase activity
DF16_RS03105	COG3944	biosynthesis protein
DF16_RS03110	COG0489	protein tyrosine kinase activity
DF16_RS03115	COG4464	protein tyrosine phosphatase activity
DF16_RS03120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DF16_RS03135	COG1216	Glycosyl transferase, family 2
DF16_RS03150	COG0463	Glycosyl transferase, family 2
DF16_RS03155	COG1215	transferase activity, transferring glycosyl groups
DF16_RS03160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DF16_RS03165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DF16_RS03170	COG1316	TRANSCRIPTIONal
DF16_RS03180	COG0745	RESPONSE REGULATOR receiver
DF16_RS03185	COG5002	protein histidine kinase activity
DF16_RS03210	COG1136	(ABC) transporter
DF16_RS03215	COG0577	efflux transmembrane transporter activity
DF16_RS03255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DF16_RS03260	COG4715	Zinc finger, swim domain protein
DF16_RS03285	COG3584	3D domain protein
DF16_RS03285	COG1388	LysM domain
DF16_RS03290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DF16_RS03300	COG1215	transferase activity, transferring glycosyl groups
DF16_RS03310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS03315	COG1388	LysM domain
DF16_RS03315	COG0791	NLP P60 protein
DF16_RS03325	COG1368	sulfuric ester hydrolase activity
DF16_RS03335	COG2389	metal-binding protein
DF16_RS03350	COG1620	l-lactate permease
DF16_RS03360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DF16_RS03365	COG1294	oxidase, subunit
DF16_RS03370	COG1271	oxidase subunit
DF16_RS03380	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DF16_RS03385	COG0583	DNA-binding transcription factor activity
DF16_RS03390	COG1511	domain protein
DF16_RS03405	COG1301	dicarboxylic acid transport
DF16_RS03410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF16_RS03420	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF16_RS03435	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF16_RS03440	COG1486	melibiose metabolic process
DF16_RS03460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DF16_RS03460	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DF16_RS03470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DF16_RS03475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DF16_RS03480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DF16_RS03485	COG1316	TRANSCRIPTIONal
DF16_RS03490	COG1739	Uncharacterized protein family UPF0029
DF16_RS03495	COG1307	EDD domain protein, DegV family
DF16_RS03500	COG1733	regulation of RNA biosynthetic process
DF16_RS03505	COG0791	NLP P60 protein
DF16_RS03505	COG1388	LysM domain
DF16_RS03510	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DF16_RS03515	COG1040	competence protein
DF16_RS03520	COG1278	Cold shock
DF16_RS03525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DF16_RS03555	COG1131	(ABC) transporter
DF16_RS03570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DF16_RS03585	COG2884	Cell division ATP-binding protein ftsE
DF16_RS03590	COG2177	Part of the ABC transporter FtsEX involved in
DF16_RS03595	COG0793	Belongs to the peptidase S41A family
DF16_RS03595	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS03600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DF16_RS03605	COG1132	(ABC) transporter
DF16_RS03615	COG0488	(ABC) transporter
DF16_RS03620	COG0655	NAD(P)H dehydrogenase (quinone) activity
DF16_RS03630	COG0583	DNA-binding transcription factor activity
DF16_RS03650	COG0789	Transcriptional regulator
DF16_RS03665	COG0556	nucleotide-excision repair
DF16_RS03670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DF16_RS03680	COG1950	PFAM Membrane protein of
DF16_RS03700	COG0110	maltose O-acetyltransferase activity
DF16_RS03705	COG0457	Tetratricopeptide repeat
DF16_RS03710	COG0492	ferredoxin-NADP+ reductase activity
DF16_RS03720	COG1051	belongs to the nudix hydrolase family
DF16_RS03730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DF16_RS03740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF16_RS03750	COG2323	membrane
DF16_RS03765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DF16_RS03790	COG0582	viral genome integration into host DNA
DF16_RS04020	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS04045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DF16_RS04060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DF16_RS04095	COG1346	cytolysis
DF16_RS04100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DF16_RS04105	COG1647	Serine aminopeptidase, S33
DF16_RS04110	COG0557	exoribonuclease II activity
DF16_RS04135	COG3344	reverse transcriptase
DF16_RS04150	COG0745	RESPONSE REGULATOR receiver
DF16_RS04200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS04205	COG0488	(ABC) transporter
DF16_RS04260	COG1252	NADH dehydrogenase
DF16_RS04270	COG1733	regulation of RNA biosynthetic process
DF16_RS04275	COG2814	Major facilitator Superfamily
DF16_RS04280	COG0656	L-ascorbic acid biosynthetic process
DF16_RS04295	COG2910	NAD(P)H-binding
DF16_RS04300	COG1115	amino acid carrier protein
DF16_RS04305	COG1115	amino acid carrier protein
DF16_RS04310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS04315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS04320	COG2311	Membrane
DF16_RS04325	COG1528	Iron-storage protein
DF16_RS04335	COG1611	Belongs to the LOG family
DF16_RS04350	COG0783	Belongs to the Dps family
DF16_RS04355	COG1115	amino acid carrier protein
DF16_RS04365	COG0490	domain, Protein
DF16_RS04370	COG0475	glutathione-regulated potassium exporter activity
DF16_RS04375	COG0586	Pfam SNARE associated Golgi protein
DF16_RS04395	COG3227	Zinc metalloprotease (Elastase)
DF16_RS04400	COG2151	metal-sulfur cluster biosynthetic enzyme
DF16_RS04405	COG0840	transmembrane signaling receptor activity
DF16_RS04435	COG5002	protein histidine kinase activity
DF16_RS04440	COG0745	RESPONSE REGULATOR receiver
DF16_RS04445	COG1376	ErfK ybiS ycfS ynhG family protein
DF16_RS04455	COG0586	Pfam SNARE associated Golgi protein
DF16_RS04490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS04510	COG0531	amino acid
DF16_RS04515	COG2814	Major facilitator Superfamily
DF16_RS04530	COG0840	transmembrane signaling receptor activity
DF16_RS04535	COG0011	TIGRFAM Protein of
DF16_RS04550	COG1686	Belongs to the peptidase S11 family
DF16_RS04560	COG1250	3-hydroxyacyl-CoA dehydrogenase
DF16_RS04560	COG1024	Enoyl-CoA hydratase
DF16_RS04565	COG0183	Belongs to the thiolase family
DF16_RS04570	COG1960	acyl-CoA dehydrogenase activity
DF16_RS04575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS04580	COG1309	transcriptional regulator
DF16_RS04595	COG0039	L-malate dehydrogenase activity
DF16_RS04615	COG1393	Belongs to the ArsC family
DF16_RS04625	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DF16_RS04630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF16_RS04645	COG2011	ABC-type metal ion transport system permease component
DF16_RS04650	COG1464	Belongs to the NlpA lipoprotein family
DF16_RS04655	COG1464	Belongs to the NlpA lipoprotein family
DF16_RS04660	COG0396	ATPase activity
DF16_RS04665	COG0719	Fe-S assembly protein
DF16_RS04670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DF16_RS04675	COG0822	iron-sulfur transferase activity
DF16_RS04680	COG0719	Fe-S assembly protein
DF16_RS04685	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS04690	COG3377	Domain of unknown function (DUF1805)
DF16_RS04700	COG0739	heme binding
DF16_RS04725	COG4377	Putative membrane peptidase family (DUF2324)
DF16_RS04730	COG0789	Transcriptional regulator
DF16_RS04740	COG4470	Protein conserved in bacteria
DF16_RS04765	COG1494	fructose-1,6-bisphosphatase
DF16_RS04770	COG2445	Protein of unknown function DUF86
DF16_RS04780	COG0647	UMP catabolic process
DF16_RS04785	COG2249	NAD(P)H dehydrogenase (quinone) activity
DF16_RS04795	COG1358	cellular component organization or biogenesis
DF16_RS04815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DF16_RS04820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DF16_RS04830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DF16_RS04835	COG4837	Protein of unknown function (DUF1462)
DF16_RS04880	COG2824	Alkylphosphonate utilization operon protein PhnA
DF16_RS04885	COG0390	transport system, permease component
DF16_RS04900	COG1252	NADH dehydrogenase
DF16_RS04915	COG0316	Belongs to the HesB IscA family
DF16_RS04920	COG2801	Transposase and inactivated derivatives
DF16_RS04925	COG2963	transposase activity
DF16_RS04960	COG1396	sequence-specific DNA binding
DF16_RS05050	COG0582	viral genome integration into host DNA
DF16_RS05100	COG1802	Transcriptional regulator
DF16_RS05100	COG4626	Terminase
DF16_RS05110	COG0740	serine-type endopeptidase activity
DF16_RS05180	COG4824	toxin secretion phage lysis holin
DF16_RS05185	COG1388	LysM domain
DF16_RS05185	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS05185	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS05245	COG1683	Conserved Protein
DF16_RS05260	COG3708	Transcriptional regulator
DF16_RS05275	COG1252	NADH dehydrogenase
DF16_RS05290	COG3584	3D domain protein
DF16_RS05305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DF16_RS05310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DF16_RS05315	COG1268	BioY protein
DF16_RS05325	COG2050	protein possibly involved in aromatic compounds catabolism
DF16_RS05330	COG2801	Transposase and inactivated derivatives
DF16_RS05355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DF16_RS05360	COG5018	Exonuclease
DF16_RS05380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DF16_RS05390	COG2267	carboxylic ester hydrolase activity
DF16_RS05395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DF16_RS05400	COG1522	sequence-specific DNA binding
DF16_RS05405	COG0436	Aminotransferase
DF16_RS05410	COG1098	S1 RNA binding domain
DF16_RS05415	COG2155	Conserved Protein
DF16_RS05435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DF16_RS05440	COG1285	pathogenesis
DF16_RS05475	COG0544	peptidyl-prolyl cis-trans isomerase activity
DF16_RS05595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DF16_RS05605	COG0058	SHG alpha-glucan phosphorylase activity
DF16_RS05640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DF16_RS05645	COG1575	Belongs to the MenA family. Type 1 subfamily
DF16_RS05650	COG1169	isochorismate synthase
DF16_RS05660	COG0596	Alpha beta hydrolase
DF16_RS05665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DF16_RS05685	COG4948	Mandelate Racemase Muconate Lactonizing
DF16_RS05705	COG3964	amidohydrolase
DF16_RS05725	COG2188	Transcriptional regulator
DF16_RS05730	COG2801	Transposase and inactivated derivatives
DF16_RS05760	COG0577	efflux transmembrane transporter activity
DF16_RS05765	COG1136	(ABC) transporter
DF16_RS05770	COG0577	efflux transmembrane transporter activity
DF16_RS05775	COG0577	efflux transmembrane transporter activity
DF16_RS05780	COG2205	protein histidine kinase activity
DF16_RS05785	COG0745	RESPONSE REGULATOR receiver
DF16_RS05790	COG0640	Transcriptional regulator
DF16_RS05795	COG5658	integral membrane protein
DF16_RS05805	COG2207	Transcriptional regulator
DF16_RS05805	COG3708	Transcriptional regulator
DF16_RS05810	COG1136	(ABC) transporter
DF16_RS05815	COG0577	efflux transmembrane transporter activity
DF16_RS05825	COG0586	Pfam SNARE associated Golgi protein
DF16_RS05855	COG1597	lipid kinase activity
DF16_RS05860	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DF16_RS05885	COG0745	RESPONSE REGULATOR receiver
DF16_RS05890	COG5002	protein histidine kinase activity
DF16_RS05920	COG1842	Phage shock protein A
DF16_RS05945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS05960	COG1294	oxidase, subunit
DF16_RS05965	COG1271	oxidase subunit
DF16_RS05970	COG0288	reversible hydration of carbon dioxide
DF16_RS05980	COG1854	S-ribosylhomocysteine lyase activity
DF16_RS06010	COG0494	nUDIX hydrolase
DF16_RS06030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF16_RS06035	COG1116	anion transmembrane transporter activity
DF16_RS06040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF16_RS06065	COG2267	carboxylic ester hydrolase activity
DF16_RS06075	COG3852	Histidine kinase
DF16_RS06080	COG5002	protein histidine kinase activity
DF16_RS06090	COG1349	DNA-binding transcription factor activity
DF16_RS06095	COG0546	phosphoglycolate phosphatase activity
DF16_RS06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS06165	COG0438	transferase activity, transferring glycosyl groups
DF16_RS06170	COG0671	phosphoesterase, PA-phosphatase related
DF16_RS06175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DF16_RS06180	COG2267	carboxylic ester hydrolase activity
DF16_RS06200	COG1794	racemase activity, acting on amino acids and derivatives
DF16_RS06205	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DF16_RS06210	COG1242	4 iron, 4 sulfur cluster binding
DF16_RS06230	COG1136	(ABC) transporter
DF16_RS06240	COG0582	viral genome integration into host DNA
DF16_RS06245	COG0490	domain, Protein
DF16_RS06250	COG0475	glutathione-regulated potassium exporter activity
DF16_RS06255	COG2814	Major facilitator Superfamily
DF16_RS06305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DF16_RS06315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF16_RS06335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DF16_RS06340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DF16_RS06350	COG0303	'Molybdopterin
DF16_RS06355	COG1763	Mo-molybdopterin cofactor biosynthetic process
DF16_RS06360	COG0314	molybdopterin synthase activity
DF16_RS06385	COG1329	Transcriptional regulator
DF16_RS06410	COG3832	glyoxalase III activity
DF16_RS06420	COG2814	Major facilitator Superfamily
DF16_RS06425	COG2081	HI0933 family
DF16_RS06430	COG2244	polysaccharide biosynthetic process
DF16_RS06435	COG1187	pseudouridine synthase activity
DF16_RS06440	COG1349	DNA-binding transcription factor activity
DF16_RS06445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF16_RS06460	COG1523	belongs to the glycosyl hydrolase 13 family
DF16_RS06465	COG0510	thiamine kinase activity
DF16_RS06480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS06490	COG1363	Peptidase, m42
DF16_RS06495	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DF16_RS06500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF16_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF16_RS06525	COG1674	ftsk spoiiie
DF16_RS06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS06555	COG2309	aminopeptidase activity
DF16_RS06565	COG3118	belongs to the thioredoxin family
DF16_RS06570	COG4851	CamS sex pheromone cAM373 precursor
DF16_RS06575	COG1605	Chorismate mutase
DF16_RS06575	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DF16_RS06585	COG1609	Transcriptional regulator
DF16_RS06640	COG0745	RESPONSE REGULATOR receiver
DF16_RS06640	COG2972	Histidine kinase
DF16_RS06645	COG0666	response to abiotic stimulus
DF16_RS06655	COG0745	RESPONSE REGULATOR receiver
DF16_RS06675	COG0517	IMP dehydrogenase activity
DF16_RS06680	COG0454	-acetyltransferase
DF16_RS06685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DF16_RS06690	COG0110	maltose O-acetyltransferase activity
DF16_RS06700	COG1595	DNA-templated transcription, initiation
DF16_RS06740	COG0626	cystathionine gamma-synthase activity
DF16_RS06745	COG1956	GAF domain-containing protein
DF16_RS06750	COG1309	transcriptional regulator
DF16_RS06755	COG0697	spore germination
DF16_RS06760	COG0583	DNA-binding transcription factor activity
DF16_RS06770	COG1104	cysteine desulfurase activity
DF16_RS06785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DF16_RS06795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DF16_RS06810	COG3874	Sporulation protein YtfJ
DF16_RS06815	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DF16_RS06820	COG0827	DNA restriction-modification system
DF16_RS06845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS06890	COG0589	response to stress
DF16_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS06910	COG0662	Cupin 2, conserved barrel domain protein
DF16_RS06945	COG0006	proline dipeptidase activity
DF16_RS06960	COG4109	DRTGG domain
DF16_RS06975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DF16_RS06990	COG0587	DNA-directed DNA polymerase activity
DF16_RS06995	COG0281	malic enzyme
DF16_RS07000	COG1725	Transcriptional regulator
DF16_RS07025	COG3030	protein affecting phage T7 exclusion by the F plasmid
DF16_RS07030	COG0628	permease
DF16_RS07045	COG0372	Belongs to the citrate synthase family
DF16_RS07050	COG0538	isocitrate dehydrogenase activity
DF16_RS07070	COG0745	RESPONSE REGULATOR receiver
DF16_RS07075	COG5002	protein histidine kinase activity
DF16_RS07080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF16_RS07080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF16_RS07090	COG1971	Probably functions as a manganese efflux pump
DF16_RS07100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DF16_RS07105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DF16_RS07115	COG3611	Membrane attachment protein
DF16_RS07120	COG1484	DNA-dependent DNA replication
DF16_RS07135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DF16_RS07160	COG1363	Peptidase, m42
DF16_RS07165	COG1309	transcriptional regulator
DF16_RS07170	COG1566	PFAM secretion protein HlyD family protein
DF16_RS07175	COG2814	Major facilitator Superfamily
DF16_RS07195	COG1418	mRNA catabolic process
DF16_RS07205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DF16_RS07250	COG1286	toxin biosynthetic process
DF16_RS07255	COG1796	DNA polymerase
DF16_RS07255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF16_RS07270	COG1187	pseudouridine synthase activity
DF16_RS07275	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS07280	COG5386	Cell surface protein
DF16_RS07290	COG5386	Cell surface protein
DF16_RS07305	COG1120	ATPase activity
DF16_RS07310	COG4509	Sortase family
DF16_RS07320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DF16_RS07325	COG4895	conserved protein (DUF2196)
DF16_RS07335	COG0745	RESPONSE REGULATOR receiver
DF16_RS07340	COG2205	protein histidine kinase activity
DF16_RS07345	COG1131	(ABC) transporter
DF16_RS07375	COG2318	DinB family
DF16_RS07400	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS07405	COG1309	transcriptional regulator
DF16_RS07410	COG1024	Enoyl-CoA hydratase
DF16_RS07415	COG2086	electron transfer activity
DF16_RS07420	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DF16_RS07425	COG3118	belongs to the thioredoxin family
DF16_RS07435	COG1719	4-vinyl reductase, 4VR
DF16_RS07440	COG2009	succinate dehydrogenase
DF16_RS07445	COG1053	succinate dehydrogenase
DF16_RS07450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DF16_RS07455	COG0824	Thioesterase
DF16_RS07460	COG1876	peptidase activity
DF16_RS07465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DF16_RS07475	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DF16_RS07480	COG4152	abc transporter atp-binding protein
DF16_RS07485	COG1668	transmembrane transport
DF16_RS07490	COG1959	2 iron, 2 sulfur cluster binding
DF16_RS07500	COG0697	spore germination
DF16_RS07505	COG1396	sequence-specific DNA binding
DF16_RS07510	COG1983	PspC domain protein
DF16_RS07515	COG0402	S-adenosylhomocysteine deaminase activity
DF16_RS07520	COG2233	PERMEase
DF16_RS07525	COG2197	response regulator
DF16_RS07545	COG5401	PFAM Sporulation and spore germination
DF16_RS07560	COG0622	Phosphoesterase
DF16_RS07610	COG0470	DNA polymerase III
DF16_RS07610	COG1067	ATP-dependent peptidase activity
DF16_RS07625	COG1764	response to oxidative stress
DF16_RS07630	COG1846	Transcriptional regulator
DF16_RS07640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DF16_RS07650	COG1587	Uroporphyrinogen-III synthase
DF16_RS07655	COG0113	porphobilinogen synthase activity
DF16_RS07665	COG1388	LysM domain
DF16_RS07680	COG0285	dihydrofolate synthase activity
DF16_RS07700	COG1077	Cell shape determining protein MreB Mrl
DF16_RS07720	COG2894	cell division
DF16_RS07725	COG0739	heme binding
DF16_RS07730	COG1994	Peptidase M50
DF16_RS07735	COG1530	ribonuclease E activity
DF16_RS07745	COG2868	ribosomal protein
DF16_RS07755	COG3290	protein histidine kinase activity
DF16_RS07765	COG0745	RESPONSE REGULATOR receiver
DF16_RS07770	COG5002	protein histidine kinase activity
DF16_RS07775	COG1136	(ABC) transporter
DF16_RS07780	COG0577	efflux transmembrane transporter activity
DF16_RS07785	COG0577	efflux transmembrane transporter activity
DF16_RS07790	COG0077	Prephenate dehydratase
DF16_RS07795	COG2258	MOSC domain
DF16_RS07800	COG1827	regulation of RNA biosynthetic process
DF16_RS07805	COG1104	cysteine desulfurase activity
DF16_RS07810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DF16_RS07815	COG0157	Belongs to the NadC ModD family
DF16_RS07845	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DF16_RS07875	COG1862	Preprotein translocase
DF16_RS07885	COG2323	membrane
DF16_RS07890	COG2244	polysaccharide biosynthetic process
DF16_RS07900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DF16_RS07900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DF16_RS07905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF16_RS07910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DF16_RS07910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DF16_RS07920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DF16_RS07945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DF16_RS07960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DF16_RS07965	COG1959	2 iron, 2 sulfur cluster binding
DF16_RS07970	COG1104	cysteine desulfurase activity
DF16_RS07985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DF16_RS08005	COG0628	permease
DF16_RS08035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DF16_RS08040	COG4122	O-methyltransferase activity
DF16_RS08045	COG0826	peptidase U32
DF16_RS08050	COG0826	peptidase U32
DF16_RS08070	COG0768	penicillin binding
DF16_RS08095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DF16_RS08100	COG0626	cystathionine gamma-synthase activity
DF16_RS08105	COG1454	alcohol dehydrogenase
DF16_RS08105	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS08115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS08155	COG2259	Doxx family
DF16_RS08160	COG2514	catechol 2,3-dioxygenase activity
DF16_RS08170	COG3186	Phenylalanine-4-hydroxylase
DF16_RS08220	COG2267	carboxylic ester hydrolase activity
DF16_RS08230	COG1785	Belongs to the alkaline phosphatase family
DF16_RS08240	COG2357	RelA SpoT domain protein
DF16_RS08245	COG0778	Nitroreductase
DF16_RS08255	COG1595	DNA-templated transcription, initiation
DF16_RS08280	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DF16_RS08285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DF16_RS08295	COG1534	Rna-binding protein
DF16_RS08305	COG1713	HD superfamily hydrolase involved in NAD metabolism
DF16_RS08310	COG0799	negative regulation of ribosome biogenesis
DF16_RS08315	COG2226	methyltransferase
DF16_RS08320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF16_RS08325	COG1596	polysaccharide export
DF16_RS08325	COG1555	photosystem II stabilization
DF16_RS08330	COG2131	deaminase
DF16_RS08340	COG2333	competence protein COMEC
DF16_RS08340	COG0658	competence protein
DF16_RS08350	COG1466	dna polymerase III delta subunit
DF16_RS08375	COG1733	regulation of RNA biosynthetic process
DF16_RS08380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DF16_RS08410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DF16_RS08415	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DF16_RS08420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DF16_RS08425	COG1610	YqeY-like protein
DF16_RS08450	COG1702	phosphate starvation-inducible protein PhoH
DF16_RS08455	COG1480	7TM receptor with intracellular HD hydrolase
DF16_RS08465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DF16_RS08470	COG0295	cytidine deaminase activity
DF16_RS08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DF16_RS08490	COG0517	IMP dehydrogenase activity
DF16_RS08505	COG0358	DNA primase activity
DF16_RS08510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DF16_RS08520	COG2384	SAM-dependent methyltransferase
DF16_RS08525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DF16_RS08555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS08560	COG1121	(ABC) transporter
DF16_RS08565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DF16_RS08570	COG0735	belongs to the Fur family
DF16_RS08585	COG5521	maltodextrose utilization protein MalA
DF16_RS08595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DF16_RS08600	COG0477	Major facilitator Superfamily
DF16_RS08605	COG0768	penicillin binding
DF16_RS08610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DF16_RS08615	COG0573	inorganic phosphate transmembrane transporter activity
DF16_RS08620	COG0573	inorganic phosphate transmembrane transporter activity
DF16_RS08630	COG0704	Plays a role in the regulation of phosphate uptake
DF16_RS08635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DF16_RS08640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DF16_RS08645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DF16_RS08650	COG4483	Protein conserved in bacteria
DF16_RS08655	COG1940	carbohydrate kinase activity
DF16_RS08665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS08685	COG0626	cystathionine gamma-synthase activity
DF16_RS08690	COG0626	cystathionine gamma-synthase activity
DF16_RS08700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DF16_RS08700	COG0646	methionine synthase
DF16_RS08760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DF16_RS08765	COG1459	type II secretion system
DF16_RS08830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DF16_RS08860	COG1725	Transcriptional regulator
DF16_RS08865	COG1131	(ABC) transporter
DF16_RS08900	COG2076	Multidrug Resistance protein
DF16_RS08905	COG2076	Multidrug Resistance protein
DF16_RS08915	COG1609	Transcriptional regulator
DF16_RS08925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF16_RS08960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DF16_RS08970	COG3872	metal-dependent enzyme
DF16_RS08985	COG0006	proline dipeptidase activity
DF16_RS09010	COG3854	ATPases associated with a variety of cellular activities
DF16_RS09055	COG0511	ligase activity, forming carbon-carbon bonds
DF16_RS09060	COG0439	Biotin carboxylase
DF16_RS09065	COG1302	Protein conserved in bacteria
DF16_RS09090	COG0142	geranyltranstransferase activity
DF16_RS09100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DF16_RS09110	COG0497	DNA recombination
DF16_RS09115	COG0750	zinc metalloprotease
DF16_RS09135	COG3093	addiction module antidote protein HigA
DF16_RS09140	COG0584	glycerophosphoryl diester phosphodiesterase
DF16_RS09150	COG3290	protein histidine kinase activity
DF16_RS09150	COG3829	transcription factor binding
DF16_RS09160	COG0280	phosphate acetyltransferase
DF16_RS09175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF16_RS09180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DF16_RS09185	COG0022	dehydrogenase e1 component
DF16_RS09190	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF16_RS09200	COG0772	Belongs to the SEDS family
DF16_RS09205	COG2323	membrane
DF16_RS09225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF16_RS09230	COG0765	amino acid transport
DF16_RS09235	COG1126	abc transporter atp-binding protein
DF16_RS09240	COG4129	membrane
DF16_RS09245	COG1376	ErfK ybiS ycfS ynhG family protein
DF16_RS09260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS09265	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF16_RS09280	COG1285	pathogenesis
DF16_RS09310	COG1760	l-serine dehydratase
DF16_RS09315	COG1760	l-serine dehydratase
DF16_RS09320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF16_RS09325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS09330	COG0300	oxidoreductase activity
DF16_RS09375	COG1522	sequence-specific DNA binding
DF16_RS09385	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS09390	COG1757	Na H antiporter
DF16_RS09400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DF16_RS09415	COG2226	methyltransferase
DF16_RS09415	COG1073	alpha beta
DF16_RS09445	COG0307	riboflavin synthase, alpha
DF16_RS09450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DF16_RS09450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DF16_RS09465	COG1073	alpha beta
DF16_RS09470	COG0456	acetyltransferase
DF16_RS09475	COG1609	Transcriptional regulator
DF16_RS09480	COG2056	Na+-H+ antiporter family
DF16_RS09485	COG0596	Alpha beta hydrolase
DF16_RS09495	COG1525	nuclease
DF16_RS09495	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS09495	COG4085	toxin activity
DF16_RS09505	COG0456	acetyltransferase
DF16_RS09505	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DF16_RS09510	COG0656	L-ascorbic acid biosynthetic process
DF16_RS09515	COG0667	Aldo Keto reductase
DF16_RS09535	COG1300	Membrane
DF16_RS09540	COG0735	belongs to the Fur family
DF16_RS09550	COG4974	Belongs to the 'phage' integrase family
DF16_RS09575	COG0598	Magnesium transport protein CorA
DF16_RS09590	COG1846	Transcriptional regulator
DF16_RS09605	COG1131	(ABC) transporter
DF16_RS09610	COG1725	Transcriptional regulator
DF16_RS09615	COG1686	Belongs to the peptidase S11 family
DF16_RS09660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DF16_RS09675	COG0697	spore germination
DF16_RS09680	COG0561	phosphatase activity
DF16_RS09685	COG4086	secreted protein
DF16_RS09690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DF16_RS09700	COG0456	acetyltransferase
DF16_RS09705	COG1547	Domain of unknown function (DUF309)
DF16_RS09735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DF16_RS09745	COG2188	Transcriptional regulator
DF16_RS09755	COG3711	transcriptional antiterminator
DF16_RS09760	COG2190	(PTS) system
DF16_RS09760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF16_RS09760	COG1263	PTS System
DF16_RS09785	COG0778	Nitroreductase
DF16_RS09790	COG2199	diguanylate cyclase activity
DF16_RS09800	COG2084	Dehydrogenase
DF16_RS09835	COG0436	Aminotransferase
DF16_RS09840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DF16_RS09870	COG0640	Transcriptional regulator
DF16_RS09875	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS09900	COG4974	Belongs to the 'phage' integrase family
DF16_RS09920	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS09925	COG1695	Transcriptional regulator
DF16_RS09960	COG0183	Belongs to the thiolase family
DF16_RS09995	COG3842	ATPase activity
DF16_RS10000	COG0366	Alpha amylase catalytic
DF16_RS10010	COG2182	Extracellular solute-binding protein
DF16_RS10015	COG1175	transmembrane transport
DF16_RS10020	COG3833	ABC-type maltose transport systems, permease component
DF16_RS10025	COG1609	Transcriptional regulator
DF16_RS10030	COG0436	Aminotransferase
DF16_RS10040	COG2205	protein histidine kinase activity
DF16_RS10050	COG3209	COG3209 Rhs family protein
DF16_RS10075	COG2814	Major facilitator Superfamily
DF16_RS10120	COG1408	metallophosphoesterase
DF16_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS10130	COG2200	EAL domain
DF16_RS10150	COG4703	Protein of unknown function (DUF1797)
DF16_RS10160	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DF16_RS10170	COG0517	IMP dehydrogenase activity
DF16_RS10175	COG0583	DNA-binding transcription factor activity
DF16_RS10195	COG0569	domain protein
DF16_RS10200	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DF16_RS10210	COG0561	phosphatase activity
DF16_RS10225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DF16_RS10230	COG0022	dehydrogenase e1 component
DF16_RS10275	COG1982	Orn Lys Arg decarboxylase major
DF16_RS10295	COG0483	inositol monophosphate 1-phosphatase activity
DF16_RS10305	COG1217	gtp-binding protein TYPA
DF16_RS10320	COG4896	Protein conserved in bacteria
DF16_RS10330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DF16_RS10335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DF16_RS10345	COG0772	Belongs to the SEDS family
DF16_RS10350	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DF16_RS10385	COG3336	cytochrome c oxidase
DF16_RS10400	COG2340	Cysteine-rich secretory protein family
DF16_RS10415	COG0406	alpha-ribazole phosphatase activity
DF16_RS10420	COG3679	Belongs to the UPF0342 family
DF16_RS10435	COG0742	ribosomal rna small subunit methyltransferase
DF16_RS10445	COG3314	Sporulation integral membrane protein YlbJ
DF16_RS10450	COG1752	Esterase of the alpha-beta hydrolase superfamily
DF16_RS10455	COG3480	Lon protease (S16) C-terminal proteolytic domain
DF16_RS10465	COG1399	metal-binding, possibly nucleic acid-binding protein
DF16_RS10470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DF16_RS10485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DF16_RS10505	COG0768	penicillin binding
DF16_RS10510	COG0768	penicillin binding
DF16_RS10530	COG0772	Belongs to the SEDS family
DF16_RS10550	COG0849	cell division
DF16_RS10555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DF16_RS10565	COG1191	sigma factor activity
DF16_RS10570	COG1191	sigma factor activity
DF16_RS10575	COG1873	PFAM PRC-barrel domain
DF16_RS10585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DF16_RS10595	COG0762	integral membrane protein
DF16_RS10600	COG2302	S4 RNA-binding domain
DF16_RS10605	COG3599	regulation of cell shape
DF16_RS10625	COG0564	pseudouridine synthase activity
DF16_RS10685	COG3069	C4-dicarboxylate transmembrane transporter activity
DF16_RS10700	COG0006	proline dipeptidase activity
DF16_RS10710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DF16_RS10715	COG1561	YicC-like family, N-terminal region
DF16_RS10735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DF16_RS10740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DF16_RS10755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DF16_RS10755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DF16_RS10765	COG0631	protein serine/threonine phosphatase activity
DF16_RS10770	COG2815	serine threonine protein kinase
DF16_RS10770	COG0515	serine threonine protein kinase
DF16_RS10780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DF16_RS10800	COG1302	Protein conserved in bacteria
DF16_RS10805	COG1461	Dihydroxyacetone kinase
DF16_RS10810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DF16_RS10825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DF16_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS10835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DF16_RS10845	COG1196	nuclear chromosome segregation
DF16_RS10850	COG3344	reverse transcriptase
DF16_RS10855	COG1196	nuclear chromosome segregation
DF16_RS10860	COG0552	protein localization to endoplasmic reticulum
DF16_RS10870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DF16_RS10880	COG1837	Belongs to the UPF0109 family
DF16_RS10920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DF16_RS10925	COG0758	DNA mediated transformation
DF16_RS10930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DF16_RS10940	COG4974	Belongs to the 'phage' integrase family
DF16_RS10985	COG4589	Belongs to the CDS family
DF16_RS10995	COG0750	zinc metalloprotease
DF16_RS11015	COG0195	Participates in both transcription termination and antitermination
DF16_RS11020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DF16_RS11025	COG1358	cellular component organization or biogenesis
DF16_RS11035	COG1550	Protein conserved in bacteria
DF16_RS11040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DF16_RS11050	COG0196	riboflavin kinase activity
DF16_RS11065	COG0726	polysaccharide deacetylase
DF16_RS11070	COG0612	Peptidase, M16
DF16_RS11075	COG1873	PFAM PRC-barrel domain
DF16_RS11080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DF16_RS11085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DF16_RS11090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DF16_RS11095	COG0527	aspartate kinase activity
DF16_RS11110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DF16_RS11115	COG0740	serine-type endopeptidase activity
DF16_RS11130	COG2188	Transcriptional regulator
DF16_RS11135	COG1744	ABC transporter substrate-binding protein PnrA-like
DF16_RS11140	COG3845	ABC transporter
DF16_RS11145	COG4603	Belongs to the binding-protein-dependent transport system permease family
DF16_RS11150	COG1079	Belongs to the binding-protein-dependent transport system permease family
DF16_RS11155	COG0612	Peptidase, M16
DF16_RS11160	COG0612	Peptidase, M16
DF16_RS11165	COG0300	oxidoreductase activity
DF16_RS11180	COG1426	Protein conserved in bacteria
DF16_RS11185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DF16_RS11205	COG1692	metallophosphoesterase
DF16_RS11210	COG2359	stage V sporulation protein S
DF16_RS11220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DF16_RS11220	COG0674	pyruvate-flavodoxin oxidoreductase activity
DF16_RS11225	COG1013	pyruvate-flavodoxin oxidoreductase activity
DF16_RS11235	COG4550	Control of competence regulator ComK, YlbF/YmcA
DF16_RS11260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DF16_RS11265	COG1368	sulfuric ester hydrolase activity
DF16_RS11275	COG3773	Cell wall hydrolase
DF16_RS11280	COG1404	Belongs to the peptidase S8 family
DF16_RS11285	COG0823	Involved in the tonB-independent uptake of proteins
DF16_RS11290	COG2723	6-phospho-beta-galactosidase activity
DF16_RS11295	COG2188	Transcriptional regulator
DF16_RS11305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS11315	COG1346	cytolysis
DF16_RS11335	COG1086	Polysaccharide biosynthesis protein
DF16_RS11355	COG3300	MHYT domain
DF16_RS11355	COG5001	Diguanylate cyclase
DF16_RS11360	COG2267	carboxylic ester hydrolase activity
DF16_RS11380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DF16_RS11385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DF16_RS11390	COG2169	Transcriptional regulator
DF16_RS11395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS11400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS11405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS11410	COG1120	ATPase activity
DF16_RS11415	COG2819	hydrolase of the alpha beta superfamily
DF16_RS11425	COG1937	Protein conserved in bacteria
DF16_RS11430	COG2608	mercury ion transmembrane transporter activity
DF16_RS11435	COG2217	Heavy metal translocating P-type atpase
DF16_RS11450	COG2116	formate transmembrane transporter activity
DF16_RS11455	COG1408	metallophosphoesterase
DF16_RS11465	COG1113	amino acid transport
DF16_RS11480	COG2322	membrane
DF16_RS11485	COG1979	alcohol dehydrogenase
DF16_RS11490	COG1349	DNA-binding transcription factor activity
DF16_RS11495	COG1105	Belongs to the carbohydrate kinase PfkB family
DF16_RS11500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF16_RS11500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF16_RS11500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DF16_RS11505	COG1388	LysM domain
DF16_RS11505	COG3584	3D domain protein
DF16_RS11540	COG0464	growth
DF16_RS11545	COG2860	membrane
DF16_RS11550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DF16_RS11555	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DF16_RS11560	COG0789	Transcriptional regulator
DF16_RS11565	COG0174	glutamine synthetase
DF16_RS11570	COG1695	Transcriptional regulator
DF16_RS11590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DF16_RS11600	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS11610	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS11615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF16_RS11650	COG1132	(ABC) transporter
DF16_RS11655	COG1132	(ABC) transporter
DF16_RS11680	COG0730	response to heat
DF16_RS11695	COG1346	cytolysis
DF16_RS11705	COG0583	DNA-binding transcription factor activity
DF16_RS11720	COG1131	(ABC) transporter
DF16_RS11730	COG2801	Transposase and inactivated derivatives
DF16_RS11740	COG1473	amidohydrolase
DF16_RS11750	COG0785	Cytochrome C biogenesis protein
DF16_RS11755	COG4846	Membrane protein involved in cytochrome C biogenesis
DF16_RS11785	COG2226	methyltransferase
DF16_RS11810	COG0010	Belongs to the arginase family
DF16_RS11815	COG1329	Transcriptional regulator
DF16_RS11825	COG3344	reverse transcriptase
DF16_RS11830	COG1902	pentaerythritol trinitrate reductase activity
DF16_RS11835	COG0069	glutamate synthase activity
DF16_RS11845	COG0346	lactoylglutathione lyase activity
DF16_RS11850	COG0400	carboxylic ester hydrolase activity
DF16_RS11855	COG5002	protein histidine kinase activity
DF16_RS11865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS11905	COG0830	nickel cation binding
DF16_RS11925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DF16_RS11950	COG1396	sequence-specific DNA binding
DF16_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS11960	COG1268	BioY protein
DF16_RS11965	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS11970	COG0183	Belongs to the thiolase family
DF16_RS11985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DF16_RS11995	COG2211	Major facilitator Superfamily
DF16_RS12025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DF16_RS12030	COG1132	(ABC) transporter
DF16_RS12045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF16_RS12080	COG0824	Thioesterase
DF16_RS12085	COG4841	protein insertion into membrane
DF16_RS12095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DF16_RS12095	COG1328	CTP reductase activity
DF16_RS12105	COG0745	RESPONSE REGULATOR receiver
DF16_RS12110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DF16_RS12115	COG1832	CoA-binding protein
DF16_RS12125	COG0187	DNA topoisomerase II activity
DF16_RS12130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DF16_RS12135	COG0673	inositol 2-dehydrogenase activity
DF16_RS12155	COG1131	(ABC) transporter
DF16_RS12165	COG1595	DNA-templated transcription, initiation
DF16_RS12175	COG1316	TRANSCRIPTIONal
DF16_RS12180	COG4166	transmembrane transport
DF16_RS12185	COG4166	transmembrane transport
DF16_RS12190	COG4166	transmembrane transport
DF16_RS12195	COG2226	methyltransferase
DF16_RS12230	COG0531	amino acid
DF16_RS12245	COG0697	spore germination
DF16_RS12260	COG2427	Protein of unknown function (DUF1641)
DF16_RS12265	COG5609	conserved protein (DUF2294)
DF16_RS12270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DF16_RS12280	COG2116	formate transmembrane transporter activity
DF16_RS12285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DF16_RS12290	COG0303	'Molybdopterin
DF16_RS12295	COG0314	molybdopterin synthase activity
DF16_RS12305	COG0489	protein tyrosine kinase activity
DF16_RS12320	COG3326	Membrane
DF16_RS12325	COG2962	Rard protein
DF16_RS12330	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DF16_RS12335	COG1657	PFAM Prenyltransferase squalene oxidase
DF16_RS12345	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS12350	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS12360	COG4145	pantothenate transmembrane transporter activity
DF16_RS12375	COG0165	Argininosuccinate lyase
DF16_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS12420	COG0716	FMN binding
DF16_RS12460	COG2720	vancomycin resistance protein
DF16_RS12465	COG2514	catechol 2,3-dioxygenase activity
DF16_RS12475	COG1285	pathogenesis
DF16_RS12485	COG3852	Histidine kinase
DF16_RS12510	COG0488	(ABC) transporter
DF16_RS12555	COG1404	Belongs to the peptidase S8 family
DF16_RS12590	COG0457	Tetratricopeptide repeat
DF16_RS12600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DF16_RS12610	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DF16_RS12635	COG3344	reverse transcriptase
DF16_RS12665	COG0697	spore germination
DF16_RS12675	COG3397	chitin binding
DF16_RS12685	COG0823	Involved in the tonB-independent uptake of proteins
DF16_RS12695	COG1252	NADH dehydrogenase
DF16_RS12700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS12700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF16_RS12710	COG1183	phosphatidylcholine synthase activity
DF16_RS12735	COG0277	FAD linked oxidase domain protein
DF16_RS12740	COG0385	Bile acid
DF16_RS12765	COG0604	alcohol dehydrogenase
DF16_RS12770	COG0640	Transcriptional regulator
DF16_RS12785	COG0584	glycerophosphoryl diester phosphodiesterase
DF16_RS12810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DF16_RS12840	COG1164	Oligoendopeptidase f
DF16_RS12845	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DF16_RS12855	COG1193	negative regulation of DNA recombination
DF16_RS12870	COG2890	protein-(glutamine-N5) methyltransferase activity
DF16_RS12880	COG0583	DNA-binding transcription factor activity
DF16_RS12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS12915	COG3739	integral membrane protein
DF16_RS12920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS12925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS12930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS12935	COG1247	-acetyltransferase
DF16_RS12945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DF16_RS12950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DF16_RS12980	COG2814	Major facilitator Superfamily
DF16_RS12985	COG1113	amino acid transport
DF16_RS13040	COG1151	hydroxylamine reductase activity
DF16_RS13095	COG1191	sigma factor activity
DF16_RS13120	COG1733	regulation of RNA biosynthetic process
DF16_RS13125	COG2249	NAD(P)H dehydrogenase (quinone) activity
DF16_RS13130	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS13150	COG0384	phenazine biosynthesis protein PhzF
DF16_RS13170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS13190	COG0673	inositol 2-dehydrogenase activity
DF16_RS13195	COG2188	Transcriptional regulator
DF16_RS13220	COG0814	amino acid
DF16_RS13235	COG1733	regulation of RNA biosynthetic process
DF16_RS13240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DF16_RS13240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DF16_RS13245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DF16_RS13245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DF16_RS13255	COG0840	transmembrane signaling receptor activity
DF16_RS13285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DF16_RS13290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DF16_RS13295	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DF16_RS13300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DF16_RS13310	COG1070	Carbohydrate kinase
DF16_RS13315	COG2706	6-phosphogluconolactonase activity
DF16_RS13320	COG3813	Protein conserved in bacteria
DF16_RS13325	COG1357	PFAM Pentapeptide repeats (8 copies)
DF16_RS13335	COG0697	spore germination
DF16_RS13365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DF16_RS13375	COG0789	Transcriptional regulator
DF16_RS13380	COG1253	flavin adenine dinucleotide binding
DF16_RS13410	COG0477	Major facilitator Superfamily
DF16_RS13420	COG0500	methyltransferase
DF16_RS13445	COG0628	permease
DF16_RS13480	COG2365	Tyrosine phosphatase family
DF16_RS13490	COG1011	Hydrolase
DF16_RS13515	COG1131	(ABC) transporter
DF16_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS13545	COG0469	pyruvate kinase activity
DF16_RS13555	COG0778	Nitroreductase
DF16_RS13560	COG1733	regulation of RNA biosynthetic process
DF16_RS13570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DF16_RS13585	COG1288	antiporter activity
DF16_RS13640	COG2249	NAD(P)H dehydrogenase (quinone) activity
DF16_RS13650	COG2031	fatty acid transporter
DF16_RS13665	COG2814	Major facilitator Superfamily
DF16_RS13670	COG1846	Transcriptional regulator
DF16_RS13685	COG0477	Major facilitator Superfamily
DF16_RS13695	COG2843	Capsule synthesis protein
DF16_RS13700	COG1876	peptidase activity
DF16_RS13725	COG5444	nuclease activity
DF16_RS13830	COG1396	sequence-specific DNA binding
DF16_RS13850	COG1309	transcriptional regulator
DF16_RS13855	COG0367	asparagine synthase
DF16_RS13885	COG1760	l-serine dehydratase
DF16_RS13890	COG1760	l-serine dehydratase
DF16_RS13895	COG0814	amino acid
DF16_RS13920	COG1533	DNA photolyase activity
DF16_RS13930	COG0076	glutamate decarboxylase activity
DF16_RS13955	COG0772	Belongs to the SEDS family
DF16_RS13960	COG2239	Acts as a magnesium transporter
DF16_RS13970	COG0768	penicillin binding
DF16_RS13975	COG1595	DNA-templated transcription, initiation
DF16_RS13985	COG0768	penicillin binding
DF16_RS13990	COG0768	penicillin binding
DF16_RS14005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS14020	COG1131	(ABC) transporter
DF16_RS14030	COG1309	transcriptional regulator
DF16_RS14045	COG1960	acyl-CoA dehydrogenase activity
DF16_RS14050	COG0439	Biotin carboxylase
DF16_RS14055	COG0511	ligase activity, forming carbon-carbon bonds
DF16_RS14060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DF16_RS14065	COG1024	Enoyl-CoA hydratase
DF16_RS14070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DF16_RS14075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DF16_RS14110	COG0572	uridine kinase
DF16_RS14125	COG1686	Belongs to the peptidase S11 family
DF16_RS14170	COG3227	Zinc metalloprotease (Elastase)
DF16_RS14175	COG2207	Transcriptional regulator
DF16_RS14230	COG1942	4-Oxalocrotonate Tautomerase
DF16_RS14235	COG0583	DNA-binding transcription factor activity
DF16_RS14245	COG1131	(ABC) transporter
DF16_RS14275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS14310	COG2323	membrane
DF16_RS14315	COG0693	protein deglycase activity
DF16_RS14325	COG3386	PFAM SMP-30 Gluconolaconase
DF16_RS14335	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DF16_RS14340	COG3773	Cell wall hydrolase
DF16_RS14350	COG0745	RESPONSE REGULATOR receiver
DF16_RS14360	COG3344	reverse transcriptase
DF16_RS14365	COG2205	protein histidine kinase activity
DF16_RS14370	COG0488	(ABC) transporter
DF16_RS14380	COG1136	(ABC) transporter
DF16_RS14385	COG0577	efflux transmembrane transporter activity
DF16_RS14405	COG0460	homoserine dehydrogenase
DF16_RS14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS14420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DF16_RS14460	COG3547	Transposase (IS116 IS110 IS902 family)
DF16_RS14485	COG2124	cytochrome p450
DF16_RS14520	COG0561	phosphatase activity
DF16_RS14540	COG1819	glycosyl
DF16_RS14570	COG0582	viral genome integration into host DNA
DF16_RS14610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF16_RS14625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DF16_RS14635	COG0745	RESPONSE REGULATOR receiver
DF16_RS14640	COG5002	protein histidine kinase activity
DF16_RS14645	COG0604	alcohol dehydrogenase
DF16_RS14650	COG0671	phosphoesterase, PA-phosphatase related
DF16_RS14655	COG0768	penicillin binding
DF16_RS14700	COG2814	Major facilitator Superfamily
DF16_RS14705	COG2814	Major facilitator Superfamily
DF16_RS14725	COG0584	glycerophosphoryl diester phosphodiesterase
DF16_RS14740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS14745	COG0697	spore germination
DF16_RS14780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DF16_RS14790	COG2223	nitrite transmembrane transporter activity
DF16_RS14805	COG0592	DNA-directed DNA polymerase activity
DF16_RS14830	COG3878	Protein conserved in bacteria
DF16_RS14855	COG4667	esterase of the alpha-beta hydrolase superfamily
DF16_RS14895	COG0322	excinuclease ABC activity
DF16_RS14915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF16_RS14945	COG0745	RESPONSE REGULATOR receiver
DF16_RS14965	COG1136	(ABC) transporter
DF16_RS14970	COG0577	efflux transmembrane transporter activity
DF16_RS14975	COG1073	alpha beta
DF16_RS14980	COG0657	acetylesterase activity
DF16_RS14985	COG0076	glutamate decarboxylase activity
DF16_RS15000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DF16_RS15020	COG1523	belongs to the glycosyl hydrolase 13 family
DF16_RS15030	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS15045	COG0201	protein transport
DF16_RS15050	COG0697	spore germination
DF16_RS15055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS15095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS15110	COG2959	enzyme of heme biosynthesis
DF16_RS15150	COG1309	transcriptional regulator
DF16_RS15180	COG3284	Transcriptional regulator
DF16_RS15215	COG1959	2 iron, 2 sulfur cluster binding
DF16_RS15225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF16_RS15230	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF16_RS15235	COG0022	dehydrogenase e1 component
DF16_RS15240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DF16_RS15250	COG2814	Major facilitator Superfamily
DF16_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS15275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DF16_RS15275	COG0456	acetyltransferase
DF16_RS15315	COG4176	ABC-type proline glycine betaine transport system permease component
DF16_RS15320	COG0517	IMP dehydrogenase activity
DF16_RS15320	COG4175	Glycine betaine
DF16_RS15350	COG2153	protein acetylation
DF16_RS15355	COG3397	chitin binding
DF16_RS15380	COG2205	protein histidine kinase activity
DF16_RS15390	COG2315	Protein conserved in bacteria
DF16_RS15435	COG0456	acetyltransferase
DF16_RS15440	COG3973	AAA domain
DF16_RS15450	COG2105	PFAM AIG2 family protein
DF16_RS15455	COG0514	ATP-dependent DNA helicase (RecQ)
DF16_RS15475	COG2801	Transposase and inactivated derivatives
DF16_RS15495	COG2801	Transposase and inactivated derivatives
DF16_RS15510	COG4637	Psort location Cytoplasmic, score
DF16_RS15525	COG3397	chitin binding
DF16_RS15540	COG1162	GTPase activity
DF16_RS15545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DF16_RS15550	COG1115	amino acid carrier protein
DF16_RS15555	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS15560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DF16_RS15570	COG3938	Belongs to the proline racemase family
DF16_RS15615	COG0586	Pfam SNARE associated Golgi protein
DF16_RS15625	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DF16_RS15635	COG4166	transmembrane transport
DF16_RS15645	COG4948	Mandelate Racemase Muconate Lactonizing
DF16_RS15660	COG0667	Aldo Keto reductase
DF16_RS15705	COG5002	protein histidine kinase activity
DF16_RS15705	COG3850	Histidine kinase
DF16_RS15710	COG0745	RESPONSE REGULATOR receiver
DF16_RS15730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DF16_RS15745	COG1307	EDD domain protein, DegV family
DF16_RS15785	COG2814	Major facilitator Superfamily
DF16_RS15795	COG1664	Polymer-forming cytoskeletal
DF16_RS15800	COG0789	Transcriptional regulator
DF16_RS15805	COG4533	DNA binding
DF16_RS15810	COG2814	Major facilitator Superfamily
DF16_RS15810	COG0477	Major facilitator Superfamily
DF16_RS15830	COG2261	transglycosylase associated protein
DF16_RS15845	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DF16_RS15880	COG0436	Aminotransferase
DF16_RS15885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DF16_RS15895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DF16_RS15910	COG1131	(ABC) transporter
DF16_RS15960	COG0628	permease
DF16_RS15975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DF16_RS15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF16_RS15985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF16_RS16015	COG2746	aminoglycoside 3-N-acetyltransferase activity
DF16_RS16035	COG0697	spore germination
DF16_RS16060	COG0346	lactoylglutathione lyase activity
DF16_RS16070	COG0861	Integral membrane protein TerC family
DF16_RS16075	COG1368	sulfuric ester hydrolase activity
DF16_RS16080	COG0488	(ABC) transporter
DF16_RS16085	COG2409	Drug exporters of the RND superfamily
DF16_RS16085	COG1033	growth of symbiont in host cell
DF16_RS16095	COG1033	growth of symbiont in host cell
DF16_RS16095	COG2409	Drug exporters of the RND superfamily
DF16_RS16100	COG1309	transcriptional regulator
DF16_RS16130	COG1605	Chorismate mutase
DF16_RS16130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DF16_RS16185	COG0277	FAD linked oxidase domain protein
DF16_RS16205	COG1879	ABC-type sugar transport system periplasmic component
DF16_RS16215	COG1172	Belongs to the binding-protein-dependent transport system permease family
DF16_RS16225	COG2390	Transcriptional regulator
DF16_RS16230	COG1070	Carbohydrate kinase
DF16_RS16255	COG2329	Antibiotic biosynthesis monooxygenase
DF16_RS16275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS16300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DF16_RS16305	COG4187	Peptidase family M20/M25/M40
DF16_RS16310	COG1414	Transcriptional regulator
DF16_RS16315	COG0833	amino acid
DF16_RS16325	COG3239	Fatty acid desaturase
DF16_RS16335	COG2720	vancomycin resistance protein
DF16_RS16340	COG1785	Belongs to the alkaline phosphatase family
DF16_RS16350	COG3655	Transcriptional regulator
DF16_RS16370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS16375	COG0346	lactoylglutathione lyase activity
DF16_RS16405	COG0714	Associated with various cellular activities
DF16_RS16450	COG0463	Glycosyl transferase, family 2
DF16_RS16475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DF16_RS16480	COG0753	catalase activity
DF16_RS16520	COG0714	Associated with various cellular activities
DF16_RS16605	COG0778	Nitroreductase
DF16_RS16610	COG1846	Transcriptional regulator
DF16_RS16630	COG4884	unkown
DF16_RS16630	COG3831	ATPase activity
DF16_RS16655	COG0037	tRNA processing
DF16_RS16655	COG0590	tRNA wobble adenosine to inosine editing
DF16_RS16660	COG0456	acetyltransferase
DF16_RS16675	COG0697	spore germination
DF16_RS16680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS16720	COG0730	response to heat
DF16_RS16735	COG0833	amino acid
DF16_RS16780	COG0768	penicillin binding
DF16_RS16815	COG1984	allophanate hydrolase subunit 2
DF16_RS16820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DF16_RS16825	COG1414	Transcriptional regulator
DF16_RS16835	COG3142	Participates in the control of copper homeostasis
DF16_RS16840	COG0640	Transcriptional regulator
DF16_RS16850	COG1960	acyl-CoA dehydrogenase activity
DF16_RS16865	COG3314	Sporulation integral membrane protein YlbJ
DF16_RS16875	COG0454	-acetyltransferase
DF16_RS16885	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DF16_RS16895	COG2801	Transposase and inactivated derivatives
DF16_RS16900	COG2963	transposase activity
DF16_RS16915	COG3848	Pyruvate phosphate dikinase
DF16_RS16915	COG0574	Belongs to the PEP-utilizing enzyme family
DF16_RS16930	COG1522	sequence-specific DNA binding
DF16_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS16940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS16960	COG1063	alcohol dehydrogenase
DF16_RS16965	COG5002	protein histidine kinase activity
DF16_RS17010	COG0737	Belongs to the 5'-nucleotidase family
DF16_RS17015	COG2267	carboxylic ester hydrolase activity
DF16_RS17020	COG1335	isochorismatase
DF16_RS17040	COG0583	DNA-binding transcription factor activity
DF16_RS17075	COG0598	Magnesium transport protein CorA
DF16_RS17120	COG0415	Belongs to the DNA photolyase family
DF16_RS17145	COG0657	acetylesterase activity
DF16_RS17150	COG0288	reversible hydration of carbon dioxide
DF16_RS17160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DF16_RS17165	COG5609	conserved protein (DUF2294)
DF16_RS17175	COG0456	acetyltransferase
DF16_RS17180	COG1575	Belongs to the MenA family. Type 1 subfamily
DF16_RS17190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS17200	COG0798	PFAM Bile acid sodium symporter
DF16_RS17205	COG0346	lactoylglutathione lyase activity
DF16_RS17210	COG0640	Transcriptional regulator
DF16_RS17220	COG2814	Major facilitator Superfamily
DF16_RS17225	COG1309	transcriptional regulator
DF16_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS17235	COG1522	sequence-specific DNA binding
DF16_RS17250	COG0346	lactoylglutathione lyase activity
DF16_RS17325	COG2814	Major facilitator Superfamily
DF16_RS17345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DF16_RS17355	COG1690	Belongs to the RtcB family
DF16_RS17365	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DF16_RS17385	COG0577	efflux transmembrane transporter activity
DF16_RS17390	COG3850	Histidine kinase
DF16_RS17390	COG5002	protein histidine kinase activity
DF16_RS17400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS17430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DF16_RS17460	COG3831	ATPase activity
DF16_RS17475	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS17475	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS17555	COG2239	Acts as a magnesium transporter
DF16_RS17560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS17570	COG0741	lytic transglycosylase activity
DF16_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS17640	COG1686	Belongs to the peptidase S11 family
DF16_RS17645	COG0110	maltose O-acetyltransferase activity
DF16_RS17650	COG0730	response to heat
DF16_RS17660	COG2801	Transposase and inactivated derivatives
DF16_RS17670	COG2002	toxin-antitoxin pair type II binding
DF16_RS17695	COG2195	Cleaves the N-terminal amino acid of tripeptides
DF16_RS17725	COG1846	Transcriptional regulator
DF16_RS17730	COG3961	Belongs to the TPP enzyme family
DF16_RS17735	COG2226	methyltransferase
DF16_RS17745	COG3615	Tellurite resistance protein tehB
DF16_RS17745	COG0500	methyltransferase
DF16_RS17765	COG1309	transcriptional regulator
DF16_RS17785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS17805	COG1846	Transcriptional regulator
DF16_RS17825	COG2971	BadF BadG BcrA BcrD
DF16_RS17830	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DF16_RS17850	COG1649	PFAM Uncharacterised BCR, COG1649
DF16_RS17875	COG1595	DNA-templated transcription, initiation
DF16_RS17880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DF16_RS17915	COG1396	sequence-specific DNA binding
DF16_RS17955	COG1132	(ABC) transporter
DF16_RS17960	COG1132	(ABC) transporter
DF16_RS17975	COG2258	MOSC domain
DF16_RS17980	COG0583	DNA-binding transcription factor activity
DF16_RS18000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DF16_RS18005	COG0583	DNA-binding transcription factor activity
DF16_RS18045	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DF16_RS18105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS18130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF16_RS18170	COG0028	Belongs to the TPP enzyme family
DF16_RS18180	COG1136	(ABC) transporter
DF16_RS18185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DF16_RS18190	COG1187	pseudouridine synthase activity
DF16_RS18195	COG2329	Antibiotic biosynthesis monooxygenase
DF16_RS18210	COG1115	amino acid carrier protein
DF16_RS18220	COG2318	DinB family
DF16_RS18230	COG0776	regulation of translation
DF16_RS18245	COG2814	Major facilitator Superfamily
DF16_RS18250	COG3251	PFAM MbtH domain protein
DF16_RS18255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DF16_RS18260	COG3433	isochorismatase activity
DF16_RS18260	COG1535	isochorismatase
DF16_RS18265	COG1021	2,3-dihydroxybenzoate-AMP ligase
DF16_RS18270	COG1169	isochorismate synthase
DF16_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS18280	COG2223	nitrite transmembrane transporter activity
DF16_RS18305	COG0419	ATPase involved in DNA repair
DF16_RS18310	COG0420	3'-5' exonuclease activity
DF16_RS18325	COG1024	Enoyl-CoA hydratase
DF16_RS18330	COG1280	lysine exporter protein (LysE YggA)
DF16_RS18340	COG2084	Dehydrogenase
DF16_RS18345	COG1960	acyl-CoA dehydrogenase activity
DF16_RS18350	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DF16_RS18355	COG2079	MmgE PrpD family protein
DF16_RS18360	COG0372	Belongs to the citrate synthase family
DF16_RS18365	COG4841	protein insertion into membrane
DF16_RS18370	COG2814	Major facilitator Superfamily
DF16_RS18380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF16_RS18380	COG4499	WXG100 protein secretion system (Wss), protein YukC
DF16_RS18480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF16_RS18485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DF16_RS18490	COG0671	phosphoesterase, PA-phosphatase related
DF16_RS18500	COG0515	serine threonine protein kinase
DF16_RS18500	COG3064	Membrane
DF16_RS18500	COG4991	sh3 domain protein
DF16_RS18535	COG1509	lysine 2,3-aminomutase activity
DF16_RS18540	COG3829	transcription factor binding
DF16_RS18545	COG0456	acetyltransferase
DF16_RS18550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF16_RS18555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DF16_RS18560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DF16_RS18565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DF16_RS18580	COG5506	Protein of unknown function (DUF1694)
DF16_RS18585	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS18590	COG1253	flavin adenine dinucleotide binding
DF16_RS18625	COG1174	glycine betaine transport
DF16_RS18630	COG0517	IMP dehydrogenase activity
DF16_RS18630	COG1125	glycine betaine transport
DF16_RS18665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DF16_RS18690	COG1064	alcohol dehydrogenase
DF16_RS18695	COG0384	phenazine biosynthesis protein PhzF
DF16_RS18700	COG1737	Transcriptional regulator
DF16_RS18705	COG2197	response regulator
DF16_RS18710	COG2203	Gaf domain
DF16_RS18710	COG4585	Histidine kinase
DF16_RS18715	COG0668	transmembrane transport
DF16_RS18725	COG1335	isochorismatase
DF16_RS18745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF16_RS18750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS18770	COG0367	asparagine synthase
DF16_RS18775	COG0071	Belongs to the small heat shock protein (HSP20) family
DF16_RS18780	COG1999	signal sequence binding
DF16_RS18790	COG1307	EDD domain protein, DegV family
DF16_RS18800	COG0805	protein transport
DF16_RS18810	COG1272	protein, Hemolysin III
DF16_RS18815	COG0204	Acyl-transferase
DF16_RS18825	COG0768	penicillin binding
DF16_RS18840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DF16_RS18855	COG0546	phosphoglycolate phosphatase activity
DF16_RS18865	COG4473	ABC transporter
DF16_RS18870	COG1131	(ABC) transporter
DF16_RS18880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DF16_RS18885	COG3655	Transcriptional regulator
DF16_RS18895	COG0456	acetyltransferase
DF16_RS18905	COG1794	racemase activity, acting on amino acids and derivatives
DF16_RS18915	COG2610	gluconate transmembrane transporter activity
DF16_RS18940	COG0733	neurotransmitter:sodium symporter activity
DF16_RS18945	COG0017	Asparaginyl-tRNA synthetase
DF16_RS18955	COG2963	transposase activity
DF16_RS18960	COG2801	Transposase and inactivated derivatives
DF16_RS19005	COG0018	arginyl-trna synthetase
DF16_RS19010	COG2136	Putative SAM-dependent methyltransferase
DF16_RS19010	COG2521	methyltransferase
DF16_RS19025	COG1413	lyase activity
DF16_RS19035	COG0629	single-stranded DNA binding
DF16_RS19145	COG0488	(ABC) transporter
DF16_RS19150	COG1418	mRNA catabolic process
DF16_RS19165	COG0457	Tetratricopeptide repeat
DF16_RS19190	COG0730	response to heat
DF16_RS19215	COG2359	stage V sporulation protein S
DF16_RS19260	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DF16_RS19265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DF16_RS19270	COG2146	nitrite reductase [NAD(P)H] activity
DF16_RS19275	COG1587	Uroporphyrinogen-III synthase
DF16_RS19275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DF16_RS19285	COG1648	precorrin-2 dehydrogenase activity
DF16_RS19295	COG2223	nitrite transmembrane transporter activity
DF16_RS19300	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DF16_RS19305	COG0314	molybdopterin synthase activity
DF16_RS19310	COG0303	'Molybdopterin
DF16_RS19315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DF16_RS19320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DF16_RS19325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF16_RS19330	COG2181	nitrate reductase activity
DF16_RS19335	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DF16_RS19340	COG1140	nitrate reductase beta subunit
DF16_RS19345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DF16_RS19355	COG0714	Associated with various cellular activities
DF16_RS19360	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DF16_RS19365	COG1305	Transglutaminase-like
DF16_RS19370	COG0386	Belongs to the glutathione peroxidase family
DF16_RS19385	COG0426	domain, Protein
DF16_RS19385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DF16_RS19400	COG1595	DNA-templated transcription, initiation
DF16_RS19405	COG0604	alcohol dehydrogenase
DF16_RS19415	COG0346	lactoylglutathione lyase activity
DF16_RS19420	COG1082	Xylose isomerase domain protein TIM barrel
DF16_RS19440	COG2226	methyltransferase
DF16_RS19465	COG3874	Sporulation protein YtfJ
DF16_RS19560	COG4499	WXG100 protein secretion system (Wss), protein YukC
DF16_RS19600	COG0456	acetyltransferase
DF16_RS19630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS19635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS19640	COG1819	glycosyl
DF16_RS19650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DF16_RS19665	COG0561	phosphatase activity
DF16_RS19745	COG3344	reverse transcriptase
DF16_RS19795	COG0740	serine-type endopeptidase activity
DF16_RS19855	COG0582	viral genome integration into host DNA
DF16_RS19930	COG3646	Phage regulatory protein
DF16_RS19960	COG0561	phosphatase activity
DF16_RS19970	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF16_RS19985	COG2211	Major facilitator Superfamily
DF16_RS20000	COG1876	peptidase activity
DF16_RS20010	COG0860	N-Acetylmuramoyl-L-alanine amidase
DF16_RS20030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DF16_RS20035	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS20040	COG2963	transposase activity
DF16_RS20045	COG2801	Transposase and inactivated derivatives
DF16_RS20060	COG1253	flavin adenine dinucleotide binding
DF16_RS20065	COG2839	Protein conserved in bacteria
DF16_RS20070	COG0702	epimerase
DF16_RS20085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF16_RS20090	COG1607	acyl-coa hydrolase
DF16_RS20095	COG3689	TIGRFAM TIGR03943 family protein
DF16_RS20100	COG0701	Predicted permease
DF16_RS20110	COG2244	polysaccharide biosynthetic process
DF16_RS20115	COG0586	Pfam SNARE associated Golgi protein
DF16_RS20120	COG1051	belongs to the nudix hydrolase family
DF16_RS20125	COG5337	Spore coat protein CotH
DF16_RS20150	COG4166	transmembrane transport
DF16_RS20160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DF16_RS20170	COG0702	epimerase
DF16_RS20185	COG0803	Belongs to the bacterial solute-binding protein 9 family
DF16_RS20190	COG0456	acetyltransferase
DF16_RS20195	COG0523	cobalamin synthesis protein
DF16_RS20205	COG4989	oxidoreductase activity
DF16_RS20210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS20215	COG1231	oxidoreductase activity
DF16_RS20225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DF16_RS20235	COG2801	Transposase and inactivated derivatives
DF16_RS20250	COG0783	Belongs to the Dps family
DF16_RS20255	COG3949	Membrane
DF16_RS20300	COG3152	Membrane
DF16_RS20310	COG2814	Major facilitator Superfamily
DF16_RS20315	COG0667	Aldo Keto reductase
DF16_RS20320	COG0640	Transcriptional regulator
DF16_RS20325	COG1404	Belongs to the peptidase S8 family
DF16_RS20330	COG2002	toxin-antitoxin pair type II binding
DF16_RS20335	COG0577	efflux transmembrane transporter activity
DF16_RS20370	COG1752	Esterase of the alpha-beta hydrolase superfamily
DF16_RS20380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS20385	COG1279	arginine transmembrane transporter activity
DF16_RS20390	COG2814	Major facilitator Superfamily
DF16_RS20400	COG1082	Xylose isomerase domain protein TIM barrel
DF16_RS20410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DF16_RS20455	COG1247	-acetyltransferase
DF16_RS20460	COG1285	pathogenesis
DF16_RS20475	COG5002	protein histidine kinase activity
DF16_RS20480	COG0745	RESPONSE REGULATOR receiver
DF16_RS20490	COG1316	TRANSCRIPTIONal
DF16_RS20515	COG0460	homoserine dehydrogenase
DF16_RS20545	COG0300	oxidoreductase activity
DF16_RS20550	COG5002	protein histidine kinase activity
DF16_RS20555	COG0745	RESPONSE REGULATOR receiver
DF16_RS20560	COG1132	(ABC) transporter
DF16_RS20570	COG0791	NLP P60 protein
DF16_RS20570	COG1388	LysM domain
DF16_RS20625	COG1216	Glycosyl transferase, family 2
DF16_RS20635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DF16_RS20640	COG4988	ABC transporter
DF16_RS20645	COG1294	oxidase, subunit
DF16_RS20650	COG1271	oxidase subunit
DF16_RS20670	COG1942	4-Oxalocrotonate Tautomerase
DF16_RS20680	COG0583	DNA-binding transcription factor activity
DF16_RS20700	COG0411	ABC transporter
DF16_RS20710	COG0523	cobalamin synthesis protein
DF16_RS20715	COG1231	oxidoreductase activity
DF16_RS20725	COG0628	permease
DF16_RS20740	COG0778	Nitroreductase
DF16_RS20745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DF16_RS20750	COG1959	2 iron, 2 sulfur cluster binding
DF16_RS20755	COG0583	DNA-binding transcription factor activity
DF16_RS20760	COG0697	spore germination
DF16_RS20765	COG4549	nuclear export factor GLE1
DF16_RS20770	COG1276	copper resistance
DF16_RS20770	COG2372	response to copper ion
DF16_RS20780	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS20800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DF16_RS20810	COG2132	Multicopper oxidase
DF16_RS20820	COG0006	proline dipeptidase activity
DF16_RS20830	COG4846	Membrane protein involved in cytochrome C biogenesis
DF16_RS20845	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DF16_RS20850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS20860	COG2390	Transcriptional regulator
DF16_RS20865	COG1309	transcriptional regulator
DF16_RS20900	COG0531	amino acid
DF16_RS20910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DF16_RS20925	COG1914	H( )-stimulated, divalent metal cation uptake system
DF16_RS20930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS20935	COG4166	transmembrane transport
DF16_RS20955	COG0427	acetyl-CoA hydrolase
DF16_RS20960	COG3279	Response regulator of the LytR AlgR family
DF16_RS20970	COG3384	dioxygenase
DF16_RS20975	COG2814	Major facilitator Superfamily
DF16_RS21000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DF16_RS21020	COG0028	Belongs to the TPP enzyme family
DF16_RS21025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF16_RS21035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DF16_RS21055	COG2323	membrane
DF16_RS21060	COG5566	PFAM Mor transcription activator
DF16_RS21065	COG0733	neurotransmitter:sodium symporter activity
DF16_RS21085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DF16_RS21090	COG2223	nitrite transmembrane transporter activity
DF16_RS21095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DF16_RS21105	COG0477	Major facilitator Superfamily
DF16_RS21115	COG1695	Transcriptional regulator
DF16_RS21135	COG2814	Major facilitator Superfamily
DF16_RS21175	COG3620	sequence-specific DNA binding
DF16_RS21185	COG2801	Transposase and inactivated derivatives
DF16_RS21210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DF16_RS21215	COG0784	Response regulator, receiver
DF16_RS21220	COG4191	Histidine kinase
DF16_RS21225	COG0281	malic enzyme
DF16_RS21230	COG1027	Aspartate ammonia-lyase
DF16_RS21245	COG0528	UMP kinase activity
DF16_RS21250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF16_RS21270	COG1131	(ABC) transporter
DF16_RS21305	COG2733	membrane
DF16_RS21325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DF16_RS21345	COG3340	Belongs to the peptidase S51 family
DF16_RS21350	COG0534	Mate efflux family protein
DF16_RS21385	COG0789	Transcriptional regulator
DF16_RS21390	COG1757	Na H antiporter
DF16_RS21410	COG0523	cobalamin synthesis protein
DF16_RS21420	COG0697	spore germination
DF16_RS21425	COG1802	Transcriptional regulator
DF16_RS21455	COG0367	asparagine synthase
DF16_RS21475	COG3547	Transposase (IS116 IS110 IS902 family)
DF16_RS21490	COG0406	alpha-ribazole phosphatase activity
DF16_RS21525	COG0725	ABC transporter, periplasmic molybdate-binding protein
DF16_RS21530	COG3842	ATPase activity
DF16_RS21535	COG0583	DNA-binding transcription factor activity
DF16_RS21595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DF16_RS21600	COG4786	Flagellar basal body rod
DF16_RS21605	COG1419	protein localization to endoplasmic reticulum
DF16_RS21610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DF16_RS21615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DF16_RS21625	COG1987	bacterial-type flagellum assembly
DF16_RS21630	COG1338	Plays a role in the flagellum-specific transport system
DF16_RS21640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF16_RS21640	COG1776	CheC inhibitor of MCP methylation
DF16_RS21645	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF16_RS21655	COG0741	lytic transglycosylase activity
DF16_RS21660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF16_RS21665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF16_RS21670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF16_RS21675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF16_RS21685	COG0835	chemotaxis
DF16_RS21685	COG0784	Response regulator, receiver
DF16_RS21720	COG1157	protein secretion by the type III secretion system
DF16_RS21730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF16_RS21735	COG1766	The M ring may be actively involved in energy transduction
DF16_RS21745	COG1558	bacterial-type flagellum-dependent cell motility
DF16_RS21750	COG1815	bacterial-type flagellum-dependent cell motility
DF16_RS21770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DF16_RS21775	COG1256	bacterial-type flagellum assembly
DF16_RS21795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DF16_RS21810	COG1776	CheC inhibitor of MCP methylation
DF16_RS21810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DF16_RS21815	COG0643	Histidine kinase
DF16_RS21815	COG2198	Histidine kinase
DF16_RS21820	COG2201	protein-glutamate methylesterase activity
DF16_RS21825	COG1360	Flagellar Motor Protein
DF16_RS21830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DF16_RS21840	COG1923	regulation of RNA biosynthetic process
DF16_RS21880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DF16_RS21885	COG2323	membrane
DF16_RS21895	COG4978	Transcriptional regulator
DF16_RS21895	COG0789	Transcriptional regulator
DF16_RS21900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DF16_RS21905	COG0475	glutathione-regulated potassium exporter activity
DF16_RS21915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DF16_RS21920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DF16_RS21940	COG1280	lysine exporter protein (LysE YggA)
DF16_RS21945	COG3403	YqcI/YcgG family
DF16_RS21980	COG0328	RNA-DNA hybrid ribonuclease activity
DF16_RS22000	COG0454	-acetyltransferase
DF16_RS22015	COG0438	transferase activity, transferring glycosyl groups
DF16_RS22020	COG1215	transferase activity, transferring glycosyl groups
DF16_RS22035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DF16_RS22045	COG3944	biosynthesis protein
DF16_RS22060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DF16_RS22100	COG0456	acetyltransferase
DF16_RS22110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DF16_RS22115	COG2311	Membrane
DF16_RS22120	COG2233	PERMEase
DF16_RS22130	COG0024	Methionine aminopeptidase
DF16_RS22140	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DF16_RS22145	COG1199	ATP-dependent helicase activity
DF16_RS22155	COG0116	Belongs to the methyltransferase superfamily
DF16_RS22205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF16_RS22205	COG4499	WXG100 protein secretion system (Wss), protein YukC
DF16_RS22215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DF16_RS22220	COG3935	DnaD domain protein
DF16_RS22240	COG1199	ATP-dependent helicase activity
DF16_RS22240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DF16_RS22280	COG0438	transferase activity, transferring glycosyl groups
DF16_RS22300	COG1694	Mazg nucleotide pyrophosphohydrolase
DF16_RS22305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS22315	COG2801	Transposase and inactivated derivatives
DF16_RS22325	COG2738	Putative neutral zinc metallopeptidase
DF16_RS22340	COG4347	Protein of unknown function (DUF1405)
DF16_RS22345	COG2010	Cytochrome c
DF16_RS22345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DF16_RS22350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DF16_RS22370	COG0457	Tetratricopeptide repeat
DF16_RS22400	COG0142	geranyltranstransferase activity
DF16_RS22410	COG0142	geranyltranstransferase activity
DF16_RS22425	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DF16_RS22495	COG0252	asparaginase activity
DF16_RS22500	COG0492	ferredoxin-NADP+ reductase activity
DF16_RS22520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DF16_RS22530	COG0789	Transcriptional regulator
DF16_RS22535	COG1408	metallophosphoesterase
DF16_RS22545	COG1266	CAAX protease self-immunity
DF16_RS22550	COG0514	ATP-dependent DNA helicase (RecQ)
DF16_RS22560	COG1141	Ferredoxin
DF16_RS22565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DF16_RS22580	COG2096	Adenosyltransferase
DF16_RS22585	COG5002	protein histidine kinase activity
DF16_RS22590	COG0745	RESPONSE REGULATOR receiver
DF16_RS22595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DF16_RS22600	COG1333	cytochrome c biogenesis protein
DF16_RS22610	COG1187	pseudouridine synthase activity
DF16_RS22615	COG0700	Nucleoside recognition
DF16_RS22620	COG2715	membrane protein required for spore maturation
DF16_RS22625	COG1686	Belongs to the peptidase S11 family
DF16_RS22630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DF16_RS22645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DF16_RS22645	COG0392	lysyltransferase activity
DF16_RS22660	COG5002	protein histidine kinase activity
DF16_RS22665	COG0582	viral genome integration into host DNA
DF16_RS22675	COG1801	Protein of unknown function DUF72
DF16_RS22680	COG3852	Histidine kinase
DF16_RS22700	COG1392	Phosphate transport regulator
DF16_RS22705	COG0306	phosphate transporter
DF16_RS22710	COG0730	response to heat
DF16_RS22765	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS22775	COG2197	response regulator
DF16_RS22780	COG4585	Histidine kinase
DF16_RS22785	COG4758	membrane
DF16_RS22800	COG1757	Na H antiporter
DF16_RS22820	COG0733	neurotransmitter:sodium symporter activity
DF16_RS22830	COG1648	precorrin-2 dehydrogenase activity
DF16_RS22850	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DF16_RS22855	COG0529	Catalyzes the synthesis of activated sulfate
DF16_RS22875	COG0019	diaminopimelate decarboxylase activity
DF16_RS22885	COG1368	sulfuric ester hydrolase activity
DF16_RS22890	COG1183	phosphatidylcholine synthase activity
DF16_RS22905	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DF16_RS22980	COG0440	acetolactate synthase activity
DF16_RS22985	COG0028	Belongs to the TPP enzyme family
DF16_RS22990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DF16_RS23020	COG3874	Sporulation protein YtfJ
DF16_RS23025	COG4709	membrane
DF16_RS23030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DF16_RS23035	COG1301	dicarboxylic acid transport
DF16_RS23045	COG1846	Transcriptional regulator
DF16_RS23095	COG0716	FMN binding
DF16_RS23120	COG1696	Membrane protein involved in D-alanine export
DF16_RS23130	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DF16_RS23135	COG2070	2-Nitropropane dioxygenase
DF16_RS23140	COG1619	proteins homologs of microcin C7 resistance protein MccF
DF16_RS23150	COG1335	isochorismatase
DF16_RS23160	COG1522	sequence-specific DNA binding
DF16_RS23180	COG1131	(ABC) transporter
DF16_RS23190	COG1131	(ABC) transporter
DF16_RS23195	COG1725	Transcriptional regulator
DF16_RS23200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF16_RS23205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF16_RS23210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DF16_RS23215	COG1780	Probably involved in ribonucleotide reductase function
DF16_RS23255	COG4873	Protein conserved in bacteria
DF16_RS23270	COG0720	synthase
DF16_RS23280	COG5002	protein histidine kinase activity
DF16_RS23290	COG2318	DinB family
DF16_RS23300	COG1846	Transcriptional regulator
DF16_RS23305	COG3852	Histidine kinase
DF16_RS23315	COG2861	carbohydrate metabolic process
DF16_RS23325	COG0235	Class ii aldolase
DF16_RS23340	COG1349	DNA-binding transcription factor activity
DF16_RS23365	COG3842	ATPase activity
DF16_RS23370	COG1840	ABC-type Fe3 transport system, periplasmic component
DF16_RS23385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DF16_RS23395	COG3243	poly(R)-hydroxyalkanoic acid synthase
DF16_RS23400	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS23420	COG2030	dehydratase
DF16_RS23430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DF16_RS23435	COG0861	Integral membrane protein TerC family
DF16_RS23440	COG2116	formate transmembrane transporter activity
DF16_RS23450	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DF16_RS23470	COG2186	Transcriptional regulator
DF16_RS23475	COG5002	protein histidine kinase activity
DF16_RS23480	COG0745	RESPONSE REGULATOR receiver
DF16_RS23490	COG3835	regulator
DF16_RS23495	COG0277	FAD linked oxidase domain protein
DF16_RS23500	COG0247	lactate metabolic process
DF16_RS23505	COG2340	Cysteine-rich secretory protein family
DF16_RS23515	COG0564	pseudouridine synthase activity
DF16_RS23525	COG2409	Drug exporters of the RND superfamily
DF16_RS23540	COG1177	transmembrane transport
DF16_RS23545	COG1176	ABC-type spermidine putrescine transport system, permease component I
DF16_RS23555	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS23590	COG0681	Belongs to the peptidase S26 family
DF16_RS23595	COG1686	Belongs to the peptidase S11 family
DF16_RS23605	COG2226	methyltransferase
DF16_RS23625	COG1668	transmembrane transport
DF16_RS23630	COG4152	abc transporter atp-binding protein
DF16_RS23680	COG1476	TRANSCRIPTIONal
DF16_RS23690	COG0508	dehydrogenase complex catalyzes the overall conversion of
DF16_RS23710	COG2226	methyltransferase
DF16_RS23715	COG2801	Transposase and inactivated derivatives
DF16_RS23760	COG5634	Uncharacterized conserved protein (DUF2278)
DF16_RS23765	COG1620	l-lactate permease
DF16_RS23800	COG0512	Glutamine amidotransferase of anthranilate synthase
DF16_RS23800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DF16_RS23815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DF16_RS23840	COG2382	esterase
DF16_RS23850	COG2153	protein acetylation
DF16_RS23895	COG1091	dTDP-4-dehydrorhamnose reductase activity
DF16_RS23910	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DF16_RS23930	COG0463	Glycosyl transferase, family 2
DF16_RS23930	COG0457	Tetratricopeptide repeat
DF16_RS23950	COG1216	Glycosyl transferase, family 2
DF16_RS23955	COG0772	Belongs to the SEDS family
DF16_RS23970	COG0564	pseudouridine synthase activity
DF16_RS23980	COG2357	RelA SpoT domain protein
DF16_RS23990	COG4116	CYTH
DF16_RS23995	COG2346	COG2346, Truncated hemoglobins
DF16_RS24010	COG1164	Oligoendopeptidase f
DF16_RS24020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DF16_RS24030	COG0861	Integral membrane protein TerC family
DF16_RS24050	COG4166	transmembrane transport
DF16_RS24055	COG0534	Mate efflux family protein
DF16_RS24060	COG4608	Belongs to the ABC transporter superfamily
DF16_RS24065	COG0444	Belongs to the ABC transporter superfamily
DF16_RS24070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF16_RS24075	COG0601	transmembrane transport
DF16_RS24080	COG4166	transmembrane transport
DF16_RS24095	COG0180	Tryptophanyl-tRNA synthetase
DF16_RS24110	COG5504	Zn-dependent protease
DF16_RS24115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DF16_RS24120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DF16_RS24135	COG2267	carboxylic ester hydrolase activity
DF16_RS24160	COG0561	phosphatase activity
DF16_RS24175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DF16_RS24200	COG2996	Protein conserved in bacteria
DF16_RS24220	COG0004	ammonium transporteR
DF16_RS24225	COG3339	Conserved Protein
DF16_RS24250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DF16_RS24260	COG0753	catalase activity
DF16_RS24270	COG0367	asparagine synthase
DF16_RS24295	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS24295	COG1388	LysM domain
DF16_RS24295	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS24300	COG4824	toxin secretion phage lysis holin
DF16_RS24370	COG3547	Transposase (IS116 IS110 IS902 family)
DF16_RS24420	COG3331	DNA recombination
DF16_RS24515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DF16_RS24530	COG0367	asparagine synthase
DF16_RS24555	COG0179	Fumarylacetoacetate (FAA) hydrolase
DF16_RS24615	COG0398	Pfam SNARE associated Golgi protein
DF16_RS24635	COG1278	Cold shock
DF16_RS24650	COG2224	Isocitrate lyase
DF16_RS24655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DF16_RS24665	COG3693	PFAM glycoside hydrolase, family 10
DF16_RS24670	COG0840	transmembrane signaling receptor activity
DF16_RS24675	COG0501	Belongs to the peptidase M48B family
DF16_RS24695	COG0745	RESPONSE REGULATOR receiver
DF16_RS24710	COG3708	Transcriptional regulator
DF16_RS24710	COG2207	Transcriptional regulator
DF16_RS24715	COG1595	DNA-templated transcription, initiation
DF16_RS24725	COG1078	dGTPase activity
DF16_RS24730	COG1408	metallophosphoesterase
DF16_RS24735	COG1073	alpha beta
DF16_RS24825	COG4208	sulfate ABC transporter
DF16_RS24835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DF16_RS24845	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS24860	COG0095	Lipoate-protein ligase
DF16_RS24865	COG1234	tRNA 3'-trailer cleavage
DF16_RS24875	COG1609	Transcriptional regulator
DF16_RS24880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS24910	COG1511	domain protein
DF16_RS24910	COG1511	domain protein
DF16_RS24915	COG1309	transcriptional regulator
DF16_RS24950	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DF16_RS24965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DF16_RS24970	COG2329	Antibiotic biosynthesis monooxygenase
DF16_RS24975	COG3428	Bacterial PH domain
DF16_RS24980	COG3402	PFAM membrane-flanked domain
DF16_RS24985	COG0697	spore germination
DF16_RS25020	COG3428	Bacterial PH domain
DF16_RS25025	COG3402	PFAM membrane-flanked domain
DF16_RS25035	COG1309	transcriptional regulator
DF16_RS25045	COG4473	ABC transporter
DF16_RS25050	COG1131	(ABC) transporter
DF16_RS25055	COG0537	adenosine 5'-monophosphoramidase activity
DF16_RS25060	COG4980	gas vesicle protein
DF16_RS25090	COG3973	AAA domain
DF16_RS25095	COG0772	Belongs to the SEDS family
DF16_RS25105	COG1595	DNA-templated transcription, initiation
DF16_RS25120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DF16_RS25130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DF16_RS25135	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DF16_RS25140	COG3620	sequence-specific DNA binding
DF16_RS25145	COG2140	Oxalate decarboxylase
DF16_RS25170	COG0457	Tetratricopeptide repeat
DF16_RS25175	COG0346	lactoylglutathione lyase activity
DF16_RS25180	COG0346	lactoylglutathione lyase activity
DF16_RS25205	COG4717	serine-type aminopeptidase activity
DF16_RS25210	COG0420	3'-5' exonuclease activity
DF16_RS25230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DF16_RS25240	COG2186	Transcriptional regulator
DF16_RS25280	COG0784	Response regulator, receiver
DF16_RS25280	COG2205	protein histidine kinase activity
DF16_RS25280	COG5002	protein histidine kinase activity
DF16_RS25285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DF16_RS25290	COG2208	phosphoserine phosphatase activity
DF16_RS25300	COG1191	sigma factor activity
DF16_RS25370	COG2373	Large extracellular alpha-helical protein
DF16_RS25430	COG2376	Dihydroxyacetone kinase
DF16_RS25455	COG0640	Transcriptional regulator
DF16_RS25460	COG2814	Major facilitator Superfamily
DF16_RS25470	COG2801	Transposase and inactivated derivatives
DF16_RS25485	COG1183	phosphatidylcholine synthase activity
DF16_RS25540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DF16_RS25555	COG1522	sequence-specific DNA binding
DF16_RS25560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DF16_RS25590	COG1073	alpha beta
DF16_RS25605	COG3344	reverse transcriptase
DF16_RS25630	COG2020	methyltransferase activity
DF16_RS25670	COG2801	Transposase and inactivated derivatives
DF16_RS25680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DF16_RS25695	COG0477	Major facilitator Superfamily
DF16_RS25705	COG1842	Phage shock protein A
DF16_RS25715	COG1288	antiporter activity
DF16_RS25720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DF16_RS25745	COG0305	Participates in initiation and elongation during chromosome replication
DF16_RS25775	COG0494	nUDIX hydrolase
DF16_RS25780	COG3181	Tripartite tricarboxylate transporter family receptor
DF16_RS25785	COG4565	transcriptional regulatory protein
DF16_RS25790	COG3290	protein histidine kinase activity
DF16_RS25795	COG0477	Major facilitator Superfamily
DF16_RS25875	COG2801	Transposase and inactivated derivatives
DF16_RS25895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS25910	COG4608	Belongs to the ABC transporter superfamily
DF16_RS25915	COG0444	Belongs to the ABC transporter superfamily
DF16_RS25920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF16_RS25925	COG0601	transmembrane transport
DF16_RS25965	COG1363	Peptidase, m42
DF16_RS25985	COG1024	Enoyl-CoA hydratase
DF16_RS26005	COG2244	polysaccharide biosynthetic process
DF16_RS26010	COG0659	secondary active sulfate transmembrane transporter activity
DF16_RS26025	COG0318	PFAM AMP-dependent synthetase and ligase
DF16_RS26030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DF16_RS26035	COG3409	Peptidoglycan-binding domain 1 protein
DF16_RS26035	COG5632	N-Acetylmuramoyl-L-alanine amidase
DF16_RS26045	COG0561	phosphatase activity
DF16_RS26060	COG3527	Alpha-acetolactate decarboxylase
DF16_RS26065	COG0028	Belongs to the TPP enzyme family
DF16_RS26095	COG0189	ligase activity
DF16_RS26110	COG1126	abc transporter atp-binding protein
DF16_RS26115	COG0765	amino acid transport
DF16_RS26120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF16_RS26125	COG1132	(ABC) transporter
DF16_RS26130	COG1132	(ABC) transporter
DF16_RS26140	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS26155	COG0531	amino acid
DF16_RS26165	COG0753	catalase activity
DF16_RS26170	COG0693	protein deglycase activity
DF16_RS26180	COG2211	Major facilitator Superfamily
DF16_RS26185	COG4533	DNA binding
DF16_RS26200	COG1733	regulation of RNA biosynthetic process
DF16_RS26205	COG2814	Major facilitator Superfamily
DF16_RS26210	COG1309	transcriptional regulator
DF16_RS26230	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS26235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DF16_RS26235	COG0165	Argininosuccinate lyase
DF16_RS26240	COG1522	sequence-specific DNA binding
DF16_RS26260	COG2259	Doxx family
DF16_RS26270	COG1263	PTS System
DF16_RS26270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF16_RS26280	COG1737	Transcriptional regulator
DF16_RS26290	COG0475	glutathione-regulated potassium exporter activity
DF16_RS26295	COG0531	amino acid
DF16_RS26330	COG0586	Pfam SNARE associated Golgi protein
DF16_RS26365	COG3546	catalase activity
DF16_RS26370	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS26385	COG5522	Integral membrane protein (intg_mem_TP0381)
DF16_RS26395	COG1136	(ABC) transporter
DF16_RS26400	COG0577	efflux transmembrane transporter activity
DF16_RS26405	COG3584	3D domain protein
DF16_RS26405	COG1388	LysM domain
DF16_RS26430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DF16_RS26435	COG1447	Phosphotransferase system cellobiose-specific component IIA
DF16_RS26440	COG3711	transcriptional antiterminator
DF16_RS26440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DF16_RS26455	COG1283	sodium-dependent phosphate transmembrane transporter activity
DF16_RS26460	COG0604	alcohol dehydrogenase
DF16_RS26465	COG1316	TRANSCRIPTIONal
DF16_RS26475	COG0730	response to heat
DF16_RS26480	COG2210	Belongs to the sulfur carrier protein TusA family
DF16_RS26495	COG0425	Belongs to the sulfur carrier protein TusA family
DF16_RS26500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF16_RS26500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DF16_RS26505	COG0425	Belongs to the sulfur carrier protein TusA family
DF16_RS26505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DF16_RS26510	COG1937	Protein conserved in bacteria
DF16_RS26515	COG0446	pyridine nucleotide-disulphide oxidoreductase
DF16_RS26525	COG3591	Belongs to the peptidase S1B family
DF16_RS26535	COG2719	SpoVR family
DF16_RS26540	COG0778	Nitroreductase
DF16_RS26600	COG1028	Short-chain dehydrogenase reductase Sdr
DF16_RS26605	COG2252	PERMEase
DF16_RS26615	COG1136	(ABC) transporter
DF16_RS26640	COG1846	Transcriptional regulator
DF16_RS26645	COG2814	Major facilitator Superfamily
DF16_RS26650	COG2205	protein histidine kinase activity
DF16_RS26690	COG0351	phosphomethylpyrimidine kinase
DF16_RS26695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DF16_RS26705	COG2104	thiamine diphosphate biosynthetic process
DF16_RS26710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF16_RS26715	COG0352	thiamine-phosphate diphosphorylase activity
DF16_RS26720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DF16_RS26725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF16_RS26730	COG1116	anion transmembrane transporter activity
DF16_RS26735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DF16_RS26760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DF16_RS26880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DF16_RS26885	COG0581	inorganic phosphate transmembrane transporter activity
DF16_RS26890	COG0573	inorganic phosphate transmembrane transporter activity
DF16_RS26895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DF16_RS26900	COG1918	ferrous iron import across plasma membrane
DF16_RS26900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DF16_RS26905	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DF16_RS26910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DF16_RS26925	COG0531	amino acid
DF16_RS26930	COG0697	spore germination
DF16_RS26935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DF16_RS26950	COG4990	cell redox homeostasis
DF16_RS26955	COG0833	amino acid
DF16_RS26965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DF16_RS26970	COG1845	cytochrome c oxidase, subunit III
DF16_RS26980	COG0475	glutathione-regulated potassium exporter activity
DF16_RS26980	COG0569	domain protein
DF16_RS26990	COG2153	protein acetylation
DF16_RS27005	COG2252	PERMEase
DF16_RS27010	COG1113	amino acid transport
DF16_RS27025	COG1114	Component of the transport system for branched-chain amino acids
DF16_RS27030	COG3104	oligopeptide transport
DF16_RS27050	COG1476	TRANSCRIPTIONal
DF16_RS27055	COG3583	domain protein
DF16_RS27055	COG3584	3D domain protein
DF16_RS27060	COG0840	transmembrane signaling receptor activity
DF16_RS27105	COG1674	ftsk spoiiie
DF16_RS27205	COG1802	Transcriptional regulator
DF16_RS27205	COG4626	Terminase
DF16_RS27255	COG0582	viral genome integration into host DNA
DF16_RS27345	COG1396	sequence-specific DNA binding
DF16_RS27375	COG2801	Transposase and inactivated derivatives
DF16_RS27385	COG1063	alcohol dehydrogenase
DF16_RS27415	COG1879	ABC-type sugar transport system periplasmic component
DF16_RS27420	COG1172	Belongs to the binding-protein-dependent transport system permease family
DF16_RS27435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DF16_RS27440	COG1609	Transcriptional regulator
DF16_RS27445	COG0477	Major facilitator Superfamily
DF16_RS27450	COG1846	Transcriptional regulator
DF16_RS27455	COG2271	Major facilitator Superfamily
DF16_RS27485	COG5002	protein histidine kinase activity
DF16_RS27490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DF16_RS27495	COG2378	regulation of single-species biofilm formation
DF16_RS27505	COG1595	DNA-templated transcription, initiation
DF16_RS27520	COG0833	amino acid
DF16_RS27525	COG0765	amino acid transport
DF16_RS27530	COG0765	amino acid transport
DF16_RS27535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF16_RS27540	COG1126	abc transporter atp-binding protein
DF16_RS27550	COG1115	amino acid carrier protein
DF16_RS27555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DF16_RS27560	COG0697	spore germination
DF16_RS27575	COG0366	Alpha amylase catalytic
DF16_RS27580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF16_RS27580	COG1263	PTS System
DF16_RS27585	COG2188	Transcriptional regulator
DF16_RS27590	COG0531	amino acid
DF16_RS27610	COG0714	Associated with various cellular activities
DF16_RS27615	COG4548	von Willebrand factor, type A
DF16_RS27625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DF16_RS27635	COG2226	methyltransferase
DF16_RS27645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS27650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS27655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS27660	COG3104	oligopeptide transport
DF16_RS27685	COG1620	l-lactate permease
DF16_RS27690	COG1027	Aspartate ammonia-lyase
DF16_RS27695	COG1253	flavin adenine dinucleotide binding
DF16_RS27700	COG0346	lactoylglutathione lyase activity
DF16_RS27710	COG3344	reverse transcriptase
DF16_RS27725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS27730	COG1316	TRANSCRIPTIONal
DF16_RS27735	COG2720	vancomycin resistance protein
DF16_RS27755	COG3227	Zinc metalloprotease (Elastase)
DF16_RS27770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DF16_RS27780	COG0640	Transcriptional regulator
DF16_RS27790	COG0531	amino acid
DF16_RS27805	COG2427	Protein of unknown function (DUF1641)
DF16_RS27810	COG3383	formate dehydrogenase (NAD+) activity
DF16_RS27815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DF16_RS27820	COG0454	-acetyltransferase
DF16_RS27820	COG0456	acetyltransferase
DF16_RS27835	COG0745	RESPONSE REGULATOR receiver
DF16_RS27840	COG5002	protein histidine kinase activity
DF16_RS27850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DF16_RS27855	COG0697	spore germination
DF16_RS27865	COG0281	malic enzyme
DF16_RS27870	COG3493	citrate carrier protein
DF16_RS27875	COG4565	transcriptional regulatory protein
DF16_RS27880	COG3290	protein histidine kinase activity
DF16_RS27890	COG4990	cell redox homeostasis
DF16_RS27900	COG3850	Histidine kinase
DF16_RS27900	COG5002	protein histidine kinase activity
DF16_RS27905	COG0745	RESPONSE REGULATOR receiver
DF16_RS27910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DF16_RS27920	COG0395	ABC-type sugar transport system, permease component
DF16_RS27925	COG1175	transmembrane transport
DF16_RS27930	COG3842	ATPase activity
DF16_RS27935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DF16_RS27960	COG2851	Citrate transporter
DF16_RS27965	COG4565	transcriptional regulatory protein
DF16_RS27970	COG3290	protein histidine kinase activity
DF16_RS27980	COG2268	Band 7 protein
DF16_RS27985	COG1585	Membrane protein implicated in regulation of membrane protease activity
DF16_RS27995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DF16_RS28015	COG2766	serine protein kinase
DF16_RS28025	COG1716	ATPase activity
DF16_RS28025	COG5001	Diguanylate cyclase
DF16_RS28030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DF16_RS28055	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DF16_RS28175	COG0735	belongs to the Fur family
DF16_RS28180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DF16_RS28200	COG4555	ABC transporter
DF16_RS28210	COG0069	glutamate synthase activity
DF16_RS28210	COG0070	glutamate synthase
DF16_RS28210	COG0067	glutamate synthase
DF16_RS28215	COG4129	membrane
DF16_RS28220	COG1132	(ABC) transporter
DF16_RS28245	COG1194	a g-specific adenine glycosylase
DF16_RS28250	COG1988	membrane-bound metal-dependent
DF16_RS28280	COG1090	epimerase
DF16_RS28285	COG1228	amidohydrolase
DF16_RS28305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DF16_RS28325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DF16_RS28325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DF16_RS28335	COG0463	Glycosyl transferase, family 2
DF16_RS28350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DF16_RS28355	COG1263	PTS System
DF16_RS28355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF16_RS28390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DF16_RS28395	COG0833	amino acid
DF16_RS28405	COG3829	transcription factor binding
DF16_RS28420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DF16_RS28425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DF16_RS28445	COG0535	radical SAM domain protein
DF16_RS28455	COG0387	Pfam Sodium calcium exchanger
DF16_RS28460	COG3871	stress protein (general stress protein 26)
DF16_RS28475	COG0586	Pfam SNARE associated Golgi protein
DF16_RS28500	COG2217	Heavy metal translocating P-type atpase
DF16_RS28505	COG1295	ribonuclease BN
DF16_RS28515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DF16_RS28530	COG3853	Toxic anion resistance protein (TelA)
DF16_RS28540	COG0861	Integral membrane protein TerC family
DF16_RS28545	COG2310	stress, protein
DF16_RS28550	COG2310	stress, protein
DF16_RS28555	COG2310	stress, protein
DF16_RS28585	COG2270	Major facilitator Superfamily
DF16_RS28630	COG1116	anion transmembrane transporter activity
DF16_RS28640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DF16_RS28660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DF16_RS28690	COG1263	PTS System
DF16_RS28690	COG2190	(PTS) system
DF16_RS28690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DF16_RS28695	COG0366	Alpha amylase catalytic
DF16_RS28710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DF16_RS28715	COG0549	Belongs to the carbamate kinase family
DF16_RS28740	COG0840	transmembrane signaling receptor activity
DF16_RS28750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DF16_RS28755	COG0765	amino acid transport
DF16_RS28765	COG0723	plastoquinol--plastocyanin reductase activity
DF16_RS28765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF16_RS28775	COG0723	plastoquinol--plastocyanin reductase activity
DF16_RS28775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DF16_RS28780	COG2814	Major facilitator Superfamily
DF16_RS28785	COG3541	Predicted nucleotidyltransferase
DF16_RS28805	COG5002	protein histidine kinase activity
DF16_RS28830	COG0166	Belongs to the GPI family
DF16_RS28845	COG0492	ferredoxin-NADP+ reductase activity
DF16_RS28855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DF16_RS28860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS28865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DF16_RS28885	COG0450	alkyl hydroperoxide reductase
DF16_RS28900	COG1473	amidohydrolase
DF16_RS28930	COG4807	Protein conserved in bacteria
DF16_RS28935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DF16_RS28945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DF16_RS28960	COG2309	aminopeptidase activity
DF16_RS28970	COG2076	Multidrug Resistance protein
DF16_RS28975	COG1012	belongs to the aldehyde dehydrogenase family
DF16_RS28985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DF16_RS28995	COG1597	lipid kinase activity
DF16_RS29015	COG4682	membrane
DF16_RS29020	COG1846	Transcriptional regulator
DF16_RS29025	COG0003	Pfam Anion-transporting ATPase
DF16_RS29040	COG1464	Belongs to the NlpA lipoprotein family
DF16_RS29045	COG2011	ABC-type metal ion transport system permease component
DF16_RS29055	COG1335	isochorismatase
DF16_RS29080	COG0210	DNA helicase
DF16_RS29110	COG0151	Belongs to the GarS family
DF16_RS29120	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DF16_RS29130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DF16_RS29145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DF16_RS29155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DF16_RS29160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DF16_RS29165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DF16_RS29195	COG0697	spore germination
DF16_RS29215	COG0463	Glycosyl transferase, family 2
DF16_RS29215	COG1216	Glycosyl transferase, family 2
DF16_RS29225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DF16_RS29445	COG0745	RESPONSE REGULATOR receiver
DF16_RS29885	COG5002	protein histidine kinase activity
DF16_RS30225	COG1266	CAAX protease self-immunity
DF16_RS30825	COG2801	Transposase and inactivated derivatives
DF16_RS30900	COG5298	Protein conserved in bacteria
DF16_RS31315	COG1045	serine acetyltransferase
DF16_RS31535	COG2244	polysaccharide biosynthetic process
DF16_RS32020	COG1214	PFAM Peptidase M22, glycoprotease
DF16_RS32175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF16_RS32180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DF16_RS32290	COG0747	negative chemotaxis
DF16_RS32695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DF16_RS32710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DF16_RS33335	COG2376	Dihydroxyacetone kinase
DF16_RS33345	COG0659	secondary active sulfate transmembrane transporter activity