locus-tag	class	description
H175_RS00010	COG0592	DNA-directed DNA polymerase activity
H175_RS00015	COG2501	S4 domain
H175_RS00025	COG0187	DNA topoisomerase II activity
H175_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS00055	COG0516	GMP reductase activity
H175_RS00055	COG0517	IMP dehydrogenase activity
H175_RS00060	COG1686	Belongs to the peptidase S11 family
H175_RS00090	COG1428	Deoxynucleoside kinase
H175_RS00095	COG1428	Deoxynucleoside kinase
H175_RS00100	COG1335	isochorismatase
H175_RS00105	COG0590	tRNA wobble adenosine to inosine editing
H175_RS00110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H175_RS00155	COG1982	Orn Lys Arg decarboxylase major
H175_RS00165	COG0470	DNA polymerase III
H175_RS00170	COG1774	PSP1 C-terminal conserved region
H175_RS00180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H175_RS00190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H175_RS00195	COG2002	toxin-antitoxin pair type II binding
H175_RS00205	COG0084	hydrolase, TatD family'
H175_RS00225	COG4466	Protein conserved in bacteria
H175_RS00240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H175_RS00245	COG0251	oxidation-reduction process
H175_RS00275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H175_RS00280	COG2002	toxin-antitoxin pair type II binding
H175_RS00285	COG2244	polysaccharide biosynthetic process
H175_RS00290	COG3956	TIGRFAM MazG family protein
H175_RS00295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H175_RS00315	COG1098	S1 RNA binding domain
H175_RS00330	COG2208	phosphoserine phosphatase activity
H175_RS00340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H175_RS00345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H175_RS00360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H175_RS00365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H175_RS00370	COG0512	Glutamine amidotransferase of anthranilate synthase
H175_RS00375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H175_RS00380	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H175_RS00385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H175_RS00390	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H175_RS00395	COG1396	sequence-specific DNA binding
H175_RS00400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H175_RS00425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS00430	COG0506	proline dehydrogenase activity
H175_RS00455	COG3880	PFAM UvrB UvrC protein
H175_RS00465	COG0542	response to heat
H175_RS00470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H175_RS00480	COG4956	integral membrane protein (PIN domain superfamily)
H175_RS00500	COG1045	serine acetyltransferase
H175_RS00515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H175_RS00520	COG3688	RNA-binding protein containing a PIN domain
H175_RS00530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H175_RS00535	COG0250	Participates in transcription elongation, termination and antitermination
H175_RS00540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H175_RS00555	COG0222	ribosome binding
H175_RS00560	COG2813	Specifically methylates the guanine in position
H175_RS00570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H175_RS00575	COG1358	cellular component organization or biogenesis
H175_RS00580	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H175_RS00600	COG0051	transcription antitermination factor activity, RNA binding
H175_RS00605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H175_RS00645	COG0255	Belongs to the universal ribosomal protein uL29 family
H175_RS00705	COG0201	protein transport
H175_RS00715	COG0024	Methionine aminopeptidase
H175_RS00725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H175_RS00760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H175_RS00785	COG0860	N-Acetylmuramoyl-L-alanine amidase
H175_RS00790	COG0489	protein tyrosine kinase activity
H175_RS00800	COG2194	sulfuric ester hydrolase activity
H175_RS00805	COG0726	polysaccharide deacetylase
H175_RS00885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H175_RS00890	COG4856	YbbR-like protein
H175_RS00930	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS00935	COG2011	ABC-type metal ion transport system permease component
H175_RS00940	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H175_RS00945	COG1464	Belongs to the NlpA lipoprotein family
H175_RS00950	COG0604	alcohol dehydrogenase
H175_RS00960	COG0277	FAD linked oxidase domain protein
H175_RS00965	COG2271	Major facilitator Superfamily
H175_RS00975	COG2814	Major facilitator Superfamily
H175_RS00995	COG0601	transmembrane transport
H175_RS01000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS01005	COG0444	Belongs to the ABC transporter superfamily
H175_RS01010	COG4608	Belongs to the ABC transporter superfamily
H175_RS01015	COG4166	transmembrane transport
H175_RS01030	COG4166	transmembrane transport
H175_RS01035	COG4166	transmembrane transport
H175_RS01040	COG0656	L-ascorbic acid biosynthetic process
H175_RS01060	COG4149	molybdate abc transporter
H175_RS01065	COG0725	ABC transporter, periplasmic molybdate-binding protein
H175_RS01070	COG1910	domain protein
H175_RS01080	COG0697	spore germination
H175_RS01090	COG0204	Acyl-transferase
H175_RS01095	COG1609	Transcriptional regulator
H175_RS01105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS01125	COG5298	Protein conserved in bacteria
H175_RS01145	COG0488	(ABC) transporter
H175_RS01155	COG0747	negative chemotaxis
H175_RS01160	COG0601	transmembrane transport
H175_RS01165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS01170	COG0444	Belongs to the ABC transporter superfamily
H175_RS01175	COG4608	Belongs to the ABC transporter superfamily
H175_RS01180	COG0561	phosphatase activity
H175_RS01200	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H175_RS01205	COG0179	Fumarylacetoacetate (FAA) hydrolase
H175_RS01215	COG0531	amino acid
H175_RS01225	COG2814	Major facilitator Superfamily
H175_RS01235	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H175_RS01245	COG4294	response to UV
H175_RS01250	COG0705	Rhomboid family
H175_RS01260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H175_RS01265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H175_RS01270	COG0864	Transcriptional regulator
H175_RS01275	COG2337	Toxic component of a toxin-antitoxin (TA) module
H175_RS01280	COG2183	response to ionizing radiation
H175_RS01375	COG0802	atpase or kinase
H175_RS01380	COG1214	PFAM Peptidase M22, glycoprotease
H175_RS01385	COG0456	acetyltransferase
H175_RS01395	COG0488	(ABC) transporter
H175_RS01410	COG1266	CAAX protease self-immunity
H175_RS01430	COG5444	nuclease activity
H175_RS01445	COG2252	PERMEase
H175_RS01455	COG5002	protein histidine kinase activity
H175_RS01480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H175_RS01535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H175_RS01545	COG1215	transferase activity, transferring glycosyl groups
H175_RS01565	COG0697	spore germination
H175_RS01590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H175_RS01595	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H175_RS01600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H175_RS01610	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H175_RS01625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H175_RS01635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H175_RS01645	COG0151	Belongs to the GarS family
H175_RS01655	COG0583	DNA-binding transcription factor activity
H175_RS01680	COG0210	DNA helicase
H175_RS01690	COG4851	CamS sex pheromone cAM373 precursor
H175_RS01705	COG1335	isochorismatase
H175_RS01720	COG2011	ABC-type metal ion transport system permease component
H175_RS01725	COG1464	Belongs to the NlpA lipoprotein family
H175_RS01735	COG0003	Pfam Anion-transporting ATPase
H175_RS01740	COG1846	Transcriptional regulator
H175_RS01745	COG4682	membrane
H175_RS01765	COG1597	lipid kinase activity
H175_RS01770	COG0546	phosphoglycolate phosphatase activity
H175_RS01775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H175_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS01790	COG2076	Multidrug Resistance protein
H175_RS01800	COG2309	aminopeptidase activity
H175_RS01815	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS01825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H175_RS01830	COG4807	Protein conserved in bacteria
H175_RS01855	COG1757	Na H antiporter
H175_RS01860	COG1473	amidohydrolase
H175_RS01880	COG0450	alkyl hydroperoxide reductase
H175_RS01900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS01910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS01915	COG0492	ferredoxin-NADP+ reductase activity
H175_RS01925	COG0166	Belongs to the GPI family
H175_RS01950	COG5002	protein histidine kinase activity
H175_RS01970	COG3541	Predicted nucleotidyltransferase
H175_RS01975	COG2814	Major facilitator Superfamily
H175_RS01980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H175_RS01980	COG0723	plastoquinol--plastocyanin reductase activity
H175_RS01990	COG0765	amino acid transport
H175_RS01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS02005	COG0840	transmembrane signaling receptor activity
H175_RS02030	COG0549	Belongs to the carbamate kinase family
H175_RS02035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H175_RS02045	COG0277	FAD linked oxidase domain protein
H175_RS02050	COG0366	Alpha amylase catalytic
H175_RS02055	COG2190	(PTS) system
H175_RS02055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS02055	COG1263	PTS System
H175_RS02085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H175_RS02105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H175_RS02110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H175_RS02115	COG1116	anion transmembrane transporter activity
H175_RS02120	COG0488	(ABC) transporter
H175_RS02165	COG2270	Major facilitator Superfamily
H175_RS02195	COG2310	stress, protein
H175_RS02200	COG2310	stress, protein
H175_RS02205	COG2310	stress, protein
H175_RS02210	COG0861	Integral membrane protein TerC family
H175_RS02220	COG3853	Toxic anion resistance protein (TelA)
H175_RS02235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H175_RS02245	COG1295	ribonuclease BN
H175_RS02250	COG2217	Heavy metal translocating P-type atpase
H175_RS02255	COG0697	spore germination
H175_RS02275	COG0586	Pfam SNARE associated Golgi protein
H175_RS02290	COG3871	stress protein (general stress protein 26)
H175_RS02295	COG0387	Pfam Sodium calcium exchanger
H175_RS02305	COG0535	radical SAM domain protein
H175_RS02325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H175_RS02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H175_RS02345	COG3829	transcription factor binding
H175_RS02355	COG0833	amino acid
H175_RS02360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H175_RS02385	COG1263	PTS System
H175_RS02385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS02390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H175_RS02405	COG1216	Glycosyl transferase, family 2
H175_RS02415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H175_RS02415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H175_RS02420	COG0463	Glycosyl transferase, family 2
H175_RS02430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H175_RS02450	COG1228	amidohydrolase
H175_RS02455	COG1090	epimerase
H175_RS02485	COG1988	membrane-bound metal-dependent
H175_RS02490	COG1194	a g-specific adenine glycosylase
H175_RS02510	COG3557	Belongs to the UPF0374 family
H175_RS02515	COG1132	(ABC) transporter
H175_RS02520	COG4129	membrane
H175_RS02525	COG0069	glutamate synthase activity
H175_RS02525	COG0067	glutamate synthase
H175_RS02525	COG0070	glutamate synthase
H175_RS02535	COG4555	ABC transporter
H175_RS02555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H175_RS02560	COG0735	belongs to the Fur family
H175_RS02680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H175_RS02705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H175_RS02715	COG2766	serine protein kinase
H175_RS02735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H175_RS02745	COG1585	Membrane protein implicated in regulation of membrane protease activity
H175_RS02750	COG2268	Band 7 protein
H175_RS02760	COG3290	protein histidine kinase activity
H175_RS02765	COG4565	transcriptional regulatory protein
H175_RS02770	COG2851	Citrate transporter
H175_RS02795	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H175_RS02800	COG3842	ATPase activity
H175_RS02805	COG1175	transmembrane transport
H175_RS02810	COG0395	ABC-type sugar transport system, permease component
H175_RS02820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H175_RS02825	COG0745	RESPONSE REGULATOR receiver
H175_RS02830	COG5002	protein histidine kinase activity
H175_RS02840	COG4990	cell redox homeostasis
H175_RS02850	COG3290	protein histidine kinase activity
H175_RS02855	COG4565	transcriptional regulatory protein
H175_RS02860	COG3493	citrate carrier protein
H175_RS02865	COG0281	malic enzyme
H175_RS02875	COG0697	spore germination
H175_RS02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS02890	COG5002	protein histidine kinase activity
H175_RS02895	COG0745	RESPONSE REGULATOR receiver
H175_RS02905	COG0454	-acetyltransferase
H175_RS02905	COG0456	acetyltransferase
H175_RS02910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H175_RS02915	COG3383	formate dehydrogenase (NAD+) activity
H175_RS02920	COG2427	Protein of unknown function (DUF1641)
H175_RS02935	COG0531	amino acid
H175_RS02940	COG0640	Transcriptional regulator
H175_RS02945	COG2217	Heavy metal translocating P-type atpase
H175_RS02950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H175_RS02960	COG3227	Zinc metalloprotease (Elastase)
H175_RS02980	COG2720	vancomycin resistance protein
H175_RS02985	COG1316	TRANSCRIPTIONal
H175_RS02990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS02995	COG0346	lactoylglutathione lyase activity
H175_RS03000	COG1253	flavin adenine dinucleotide binding
H175_RS03005	COG1027	Aspartate ammonia-lyase
H175_RS03010	COG1620	l-lactate permease
H175_RS03025	COG3104	oligopeptide transport
H175_RS03030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS03035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS03040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS03060	COG3344	reverse transcriptase
H175_RS03065	COG0156	8-amino-7-oxononanoate synthase activity
H175_RS03070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H175_RS03080	COG4548	von Willebrand factor, type A
H175_RS03085	COG0714	Associated with various cellular activities
H175_RS03105	COG0531	amino acid
H175_RS03110	COG2188	Transcriptional regulator
H175_RS03115	COG1263	PTS System
H175_RS03115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS03120	COG0366	Alpha amylase catalytic
H175_RS03135	COG0697	spore germination
H175_RS03145	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H175_RS03150	COG1115	amino acid carrier protein
H175_RS03155	COG1126	abc transporter atp-binding protein
H175_RS03160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS03165	COG0765	amino acid transport
H175_RS03170	COG0765	amino acid transport
H175_RS03175	COG0833	amino acid
H175_RS03190	COG1595	DNA-templated transcription, initiation
H175_RS03200	COG2378	regulation of single-species biofilm formation
H175_RS03210	COG5002	protein histidine kinase activity
H175_RS03235	COG0659	secondary active sulfate transmembrane transporter activity
H175_RS03250	COG0747	negative chemotaxis
H175_RS03260	COG0601	transmembrane transport
H175_RS03265	COG4608	Belongs to the ABC transporter superfamily
H175_RS03275	COG2271	Major facilitator Superfamily
H175_RS03280	COG1846	Transcriptional regulator
H175_RS03285	COG0477	Major facilitator Superfamily
H175_RS03290	COG1609	Transcriptional regulator
H175_RS03295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H175_RS03310	COG1172	Belongs to the binding-protein-dependent transport system permease family
H175_RS03315	COG1879	ABC-type sugar transport system periplasmic component
H175_RS03335	COG1063	alcohol dehydrogenase
H175_RS03365	COG1396	sequence-specific DNA binding
H175_RS03405	COG5377	YqaJ viral recombinase family
H175_RS03410	COG3723	Recombinational DNA repair protein, rece pathway
H175_RS03425	COG1484	DNA-dependent DNA replication
H175_RS03470	COG3617	BRO family, N-terminal domain
H175_RS03495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H175_RS03590	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS03590	COG5632	N-Acetylmuramoyl-L-alanine amidase
H175_RS03590	COG1388	LysM domain
H175_RS03610	COG1674	ftsk spoiiie
H175_RS03655	COG0840	transmembrane signaling receptor activity
H175_RS03660	COG3584	3D domain protein
H175_RS03660	COG1388	LysM domain
H175_RS03665	COG1476	TRANSCRIPTIONal
H175_RS03685	COG3104	oligopeptide transport
H175_RS03690	COG1114	Component of the transport system for branched-chain amino acids
H175_RS03705	COG1113	amino acid transport
H175_RS03710	COG2252	PERMEase
H175_RS03725	COG2153	protein acetylation
H175_RS03735	COG0569	domain protein
H175_RS03735	COG0475	glutathione-regulated potassium exporter activity
H175_RS03745	COG1845	cytochrome c oxidase, subunit III
H175_RS03750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H175_RS03760	COG0833	amino acid
H175_RS03765	COG4990	cell redox homeostasis
H175_RS03780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H175_RS03785	COG0697	spore germination
H175_RS03790	COG0531	amino acid
H175_RS03800	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H175_RS03805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H175_RS03810	COG1918	ferrous iron import across plasma membrane
H175_RS03810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H175_RS03815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H175_RS03820	COG0573	inorganic phosphate transmembrane transporter activity
H175_RS03825	COG0581	inorganic phosphate transmembrane transporter activity
H175_RS03835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H175_RS03950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
H175_RS03970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H175_RS03975	COG1116	anion transmembrane transporter activity
H175_RS03980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H175_RS03985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H175_RS03990	COG0352	thiamine-phosphate diphosphorylase activity
H175_RS03995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H175_RS04000	COG2104	thiamine diphosphate biosynthetic process
H175_RS04010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H175_RS04015	COG0351	phosphomethylpyrimidine kinase
H175_RS04055	COG2205	protein histidine kinase activity
H175_RS04060	COG2814	Major facilitator Superfamily
H175_RS04065	COG1846	Transcriptional regulator
H175_RS04080	COG2252	PERMEase
H175_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H175_RS04105	COG1621	beta-fructofuranosidase activity
H175_RS04110	COG1263	PTS System
H175_RS04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS04115	COG1609	Transcriptional regulator
H175_RS04165	COG0778	Nitroreductase
H175_RS04170	COG2719	SpoVR family
H175_RS04175	COG1414	Transcriptional regulator
H175_RS04190	COG0446	pyridine nucleotide-disulphide oxidoreductase
H175_RS04195	COG1937	Protein conserved in bacteria
H175_RS04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H175_RS04200	COG0425	Belongs to the sulfur carrier protein TusA family
H175_RS04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H175_RS04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS04210	COG0425	Belongs to the sulfur carrier protein TusA family
H175_RS04215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H175_RS04225	COG2210	Belongs to the sulfur carrier protein TusA family
H175_RS04230	COG0730	response to heat
H175_RS04240	COG1316	TRANSCRIPTIONal
H175_RS04245	COG0604	alcohol dehydrogenase
H175_RS04250	COG1283	sodium-dependent phosphate transmembrane transporter activity
H175_RS04265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H175_RS04265	COG3711	transcriptional antiterminator
H175_RS04270	COG1447	Phosphotransferase system cellobiose-specific component IIA
H175_RS04275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H175_RS04295	COG1388	LysM domain
H175_RS04295	COG3584	3D domain protein
H175_RS04300	COG0577	efflux transmembrane transporter activity
H175_RS04305	COG1136	(ABC) transporter
H175_RS04315	COG5522	Integral membrane protein (intg_mem_TP0381)
H175_RS04330	COG1114	Component of the transport system for branched-chain amino acids
H175_RS04335	COG3546	catalase activity
H175_RS04370	COG0586	Pfam SNARE associated Golgi protein
H175_RS04405	COG0531	amino acid
H175_RS04410	COG0475	glutathione-regulated potassium exporter activity
H175_RS04420	COG1737	Transcriptional regulator
H175_RS04430	COG1263	PTS System
H175_RS04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS04440	COG2259	Doxx family
H175_RS04460	COG1522	sequence-specific DNA binding
H175_RS04465	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H175_RS04465	COG0165	Argininosuccinate lyase
H175_RS04470	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS04490	COG1309	transcriptional regulator
H175_RS04495	COG2814	Major facilitator Superfamily
H175_RS04500	COG1733	regulation of RNA biosynthetic process
H175_RS04515	COG4533	DNA binding
H175_RS04520	COG2211	Major facilitator Superfamily
H175_RS04530	COG0693	protein deglycase activity
H175_RS04535	COG0693	protein deglycase activity
H175_RS04535	COG0753	catalase activity
H175_RS04545	COG0531	amino acid
H175_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS04565	COG1132	(ABC) transporter
H175_RS04570	COG1132	(ABC) transporter
H175_RS04575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS04580	COG0765	amino acid transport
H175_RS04585	COG1126	abc transporter atp-binding protein
H175_RS04600	COG0189	ligase activity
H175_RS04635	COG0028	Belongs to the TPP enzyme family
H175_RS04640	COG3527	Alpha-acetolactate decarboxylase
H175_RS04655	COG0561	phosphatase activity
H175_RS04665	COG5632	N-Acetylmuramoyl-L-alanine amidase
H175_RS04665	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H175_RS04675	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS04690	COG0659	secondary active sulfate transmembrane transporter activity
H175_RS04695	COG2244	polysaccharide biosynthetic process
H175_RS04715	COG1024	Enoyl-CoA hydratase
H175_RS04735	COG1363	Peptidase, m42
H175_RS04775	COG0601	transmembrane transport
H175_RS04780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS04785	COG0444	Belongs to the ABC transporter superfamily
H175_RS04790	COG4608	Belongs to the ABC transporter superfamily
H175_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS04830	COG0477	Major facilitator Superfamily
H175_RS04835	COG3290	protein histidine kinase activity
H175_RS04840	COG4565	transcriptional regulatory protein
H175_RS04845	COG3181	Tripartite tricarboxylate transporter family receptor
H175_RS04850	COG0494	nUDIX hydrolase
H175_RS04865	COG0305	Participates in initiation and elongation during chromosome replication
H175_RS04895	COG0477	Major facilitator Superfamily
H175_RS04920	COG1073	alpha beta
H175_RS04960	COG1183	phosphatidylcholine synthase activity
H175_RS04970	COG2814	Major facilitator Superfamily
H175_RS04975	COG0640	Transcriptional regulator
H175_RS04985	COG2376	Dihydroxyacetone kinase
H175_RS05040	COG0457	Tetratricopeptide repeat
H175_RS05045	COG2373	Large extracellular alpha-helical protein
H175_RS05075	COG0596	Alpha beta hydrolase
H175_RS05100	COG3237	CsbD-like
H175_RS05125	COG1191	sigma factor activity
H175_RS05135	COG2208	phosphoserine phosphatase activity
H175_RS05140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H175_RS05145	COG2205	protein histidine kinase activity
H175_RS05145	COG2198	Histidine kinase
H175_RS05145	COG0784	Response regulator, receiver
H175_RS05175	COG2801	Transposase and inactivated derivatives
H175_RS05185	COG3344	reverse transcriptase
H175_RS05195	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H175_RS05215	COG0420	3'-5' exonuclease activity
H175_RS05220	COG4717	serine-type aminopeptidase activity
H175_RS05235	COG1280	lysine exporter protein (LysE YggA)
H175_RS05240	COG0346	lactoylglutathione lyase activity
H175_RS05245	COG0346	lactoylglutathione lyase activity
H175_RS05255	COG0457	Tetratricopeptide repeat
H175_RS05265	COG2267	carboxylic ester hydrolase activity
H175_RS05290	COG2140	Oxalate decarboxylase
H175_RS05295	COG3620	sequence-specific DNA binding
H175_RS05300	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H175_RS05305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H175_RS05315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H175_RS05320	COG1695	Transcriptional regulator
H175_RS05330	COG1595	DNA-templated transcription, initiation
H175_RS05345	COG3973	AAA domain
H175_RS05375	COG4980	gas vesicle protein
H175_RS05380	COG0537	adenosine 5'-monophosphoramidase activity
H175_RS05385	COG1131	(ABC) transporter
H175_RS05390	COG4473	ABC transporter
H175_RS05435	COG1309	transcriptional regulator
H175_RS05445	COG3402	PFAM membrane-flanked domain
H175_RS05450	COG3428	Bacterial PH domain
H175_RS05495	COG0697	spore germination
H175_RS05500	COG3402	PFAM membrane-flanked domain
H175_RS05505	COG3428	Bacterial PH domain
H175_RS05510	COG2329	Antibiotic biosynthesis monooxygenase
H175_RS05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H175_RS05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H175_RS05565	COG1309	transcriptional regulator
H175_RS05570	COG1511	domain protein
H175_RS05590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS05595	COG1609	Transcriptional regulator
H175_RS05605	COG1234	tRNA 3'-trailer cleavage
H175_RS05610	COG0095	Lipoate-protein ligase
H175_RS05620	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS05630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H175_RS05640	COG4208	sulfate ABC transporter
H175_RS05655	COG1408	metallophosphoesterase
H175_RS05660	COG1078	dGTPase activity
H175_RS05670	COG1595	DNA-templated transcription, initiation
H175_RS05675	COG3708	Transcriptional regulator
H175_RS05675	COG2207	Transcriptional regulator
H175_RS05680	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS05685	COG2205	protein histidine kinase activity
H175_RS05690	COG0745	RESPONSE REGULATOR receiver
H175_RS05710	COG0501	Belongs to the peptidase M48B family
H175_RS05715	COG0840	transmembrane signaling receptor activity
H175_RS05720	COG3693	PFAM glycoside hydrolase, family 10
H175_RS05730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H175_RS05735	COG2224	Isocitrate lyase
H175_RS05750	COG1278	Cold shock
H175_RS05770	COG0398	Pfam SNARE associated Golgi protein
H175_RS05790	COG0202	RNA polymerase activity
H175_RS05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
H175_RS05855	COG0367	asparagine synthase
H175_RS05865	COG0753	catalase activity
H175_RS05870	COG0004	ammonium transporteR
H175_RS05890	COG2996	Protein conserved in bacteria
H175_RS05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS05915	COG0561	phosphatase activity
H175_RS05935	COG2267	carboxylic ester hydrolase activity
H175_RS05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H175_RS05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H175_RS05960	COG5504	Zn-dependent protease
H175_RS05970	COG0180	Tryptophanyl-tRNA synthetase
H175_RS05980	COG4166	transmembrane transport
H175_RS05985	COG0601	transmembrane transport
H175_RS05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS05995	COG0444	Belongs to the ABC transporter superfamily
H175_RS06000	COG4608	Belongs to the ABC transporter superfamily
H175_RS06005	COG0534	Mate efflux family protein
H175_RS06010	COG4166	transmembrane transport
H175_RS06025	COG0861	Integral membrane protein TerC family
H175_RS06035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H175_RS06045	COG1164	Oligoendopeptidase f
H175_RS06055	COG2346	COG2346, Truncated hemoglobins
H175_RS06060	COG4116	CYTH
H175_RS06070	COG2357	RelA SpoT domain protein
H175_RS06080	COG0564	pseudouridine synthase activity
H175_RS06095	COG0772	Belongs to the SEDS family
H175_RS06100	COG1216	Glycosyl transferase, family 2
H175_RS06120	COG0457	Tetratricopeptide repeat
H175_RS06120	COG0463	Glycosyl transferase, family 2
H175_RS06140	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H175_RS06155	COG1091	dTDP-4-dehydrorhamnose reductase activity
H175_RS06200	COG2153	protein acetylation
H175_RS06210	COG2382	esterase
H175_RS06230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H175_RS06240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H175_RS06240	COG0512	Glutamine amidotransferase of anthranilate synthase
H175_RS06275	COG1620	l-lactate permease
H175_RS06280	COG5634	Uncharacterized conserved protein (DUF2278)
H175_RS06295	COG4640	response to antibiotic
H175_RS06320	COG2226	methyltransferase
H175_RS06340	COG0508	dehydrogenase complex catalyzes the overall conversion of
H175_RS06350	COG1476	TRANSCRIPTIONal
H175_RS06420	COG1686	Belongs to the peptidase S11 family
H175_RS06425	COG0681	Belongs to the peptidase S26 family
H175_RS06460	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS06470	COG1176	ABC-type spermidine putrescine transport system, permease component I
H175_RS06475	COG1177	transmembrane transport
H175_RS06490	COG2409	Drug exporters of the RND superfamily
H175_RS06500	COG0564	pseudouridine synthase activity
H175_RS06510	COG2340	Cysteine-rich secretory protein family
H175_RS06515	COG0247	lactate metabolic process
H175_RS06520	COG0277	FAD linked oxidase domain protein
H175_RS06525	COG3835	regulator
H175_RS06535	COG0745	RESPONSE REGULATOR receiver
H175_RS06540	COG5002	protein histidine kinase activity
H175_RS06545	COG2186	Transcriptional regulator
H175_RS06565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H175_RS06575	COG2116	formate transmembrane transporter activity
H175_RS06580	COG0861	Integral membrane protein TerC family
H175_RS06585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H175_RS06595	COG2030	dehydratase
H175_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS06620	COG3243	poly(R)-hydroxyalkanoic acid synthase
H175_RS06630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H175_RS06645	COG1840	ABC-type Fe3 transport system, periplasmic component
H175_RS06650	COG3842	ATPase activity
H175_RS06675	COG1349	DNA-binding transcription factor activity
H175_RS06690	COG0235	Class ii aldolase
H175_RS06700	COG2801	Transposase and inactivated derivatives
H175_RS06710	COG2861	carbohydrate metabolic process
H175_RS06720	COG3852	Histidine kinase
H175_RS06725	COG1846	Transcriptional regulator
H175_RS06735	COG2318	DinB family
H175_RS06745	COG5002	protein histidine kinase activity
H175_RS06755	COG0720	synthase
H175_RS06770	COG4873	Protein conserved in bacteria
H175_RS06800	COG1780	Probably involved in ribonucleotide reductase function
H175_RS06805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H175_RS06810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H175_RS06815	COG1725	Transcriptional regulator
H175_RS06820	COG1131	(ABC) transporter
H175_RS06830	COG1131	(ABC) transporter
H175_RS06850	COG1522	sequence-specific DNA binding
H175_RS06860	COG1335	isochorismatase
H175_RS06870	COG1619	proteins homologs of microcin C7 resistance protein MccF
H175_RS06875	COG2070	2-Nitropropane dioxygenase
H175_RS06880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H175_RS06890	COG1696	Membrane protein involved in D-alanine export
H175_RS06915	COG0716	FMN binding
H175_RS06970	COG1846	Transcriptional regulator
H175_RS06985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H175_RS06990	COG4709	membrane
H175_RS06995	COG3874	Sporulation protein YtfJ
H175_RS07015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H175_RS07020	COG0028	Belongs to the TPP enzyme family
H175_RS07025	COG0440	acetolactate synthase activity
H175_RS07100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H175_RS07115	COG1183	phosphatidylcholine synthase activity
H175_RS07120	COG1368	sulfuric ester hydrolase activity
H175_RS07130	COG0019	diaminopimelate decarboxylase activity
H175_RS07150	COG0529	Catalyzes the synthesis of activated sulfate
H175_RS07155	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H175_RS07175	COG1648	precorrin-2 dehydrogenase activity
H175_RS07180	COG0733	neurotransmitter:sodium symporter activity
H175_RS07200	COG1757	Na H antiporter
H175_RS07215	COG4758	membrane
H175_RS07220	COG4585	Histidine kinase
H175_RS07225	COG2197	response regulator
H175_RS07235	COG1114	Component of the transport system for branched-chain amino acids
H175_RS07245	COG2226	methyltransferase
H175_RS07285	COG0730	response to heat
H175_RS07290	COG0306	phosphate transporter
H175_RS07295	COG1392	Phosphate transport regulator
H175_RS07300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H175_RS07315	COG3852	Histidine kinase
H175_RS07320	COG1801	Protein of unknown function DUF72
H175_RS07330	COG0582	viral genome integration into host DNA
H175_RS07335	COG5002	protein histidine kinase activity
H175_RS07350	COG0392	lysyltransferase activity
H175_RS07350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H175_RS07365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H175_RS07370	COG1686	Belongs to the peptidase S11 family
H175_RS07375	COG2715	membrane protein required for spore maturation
H175_RS07380	COG0700	Nucleoside recognition
H175_RS07385	COG1187	pseudouridine synthase activity
H175_RS07395	COG1333	cytochrome c biogenesis protein
H175_RS07400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H175_RS07405	COG0745	RESPONSE REGULATOR receiver
H175_RS07410	COG5002	protein histidine kinase activity
H175_RS07415	COG2096	Adenosyltransferase
H175_RS07430	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H175_RS07435	COG1141	Ferredoxin
H175_RS07445	COG0514	ATP-dependent DNA helicase (RecQ)
H175_RS07450	COG1266	CAAX protease self-immunity
H175_RS07460	COG1408	metallophosphoesterase
H175_RS07465	COG0789	Transcriptional regulator
H175_RS07475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H175_RS07495	COG0492	ferredoxin-NADP+ reductase activity
H175_RS07500	COG0252	asparaginase activity
H175_RS07565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H175_RS07580	COG0142	geranyltranstransferase activity
H175_RS07590	COG0142	geranyltranstransferase activity
H175_RS07615	COG0457	Tetratricopeptide repeat
H175_RS07635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H175_RS07640	COG2010	Cytochrome c
H175_RS07640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H175_RS07645	COG4347	Protein of unknown function (DUF1405)
H175_RS07660	COG2738	Putative neutral zinc metallopeptidase
H175_RS07670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS07675	COG1694	Mazg nucleotide pyrophosphohydrolase
H175_RS07695	COG0438	transferase activity, transferring glycosyl groups
H175_RS07730	COG1199	ATP-dependent helicase activity
H175_RS07730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H175_RS07750	COG3935	DnaD domain protein
H175_RS07755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H175_RS07765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H175_RS07765	COG4499	WXG100 protein secretion system (Wss), protein YukC
H175_RS07815	COG0116	Belongs to the methyltransferase superfamily
H175_RS07825	COG1199	ATP-dependent helicase activity
H175_RS07830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H175_RS07840	COG0024	Methionine aminopeptidase
H175_RS07850	COG2233	PERMEase
H175_RS07855	COG2311	Membrane
H175_RS07860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H175_RS07870	COG0456	acetyltransferase
H175_RS07910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H175_RS07925	COG3944	biosynthesis protein
H175_RS07935	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H175_RS07950	COG1215	transferase activity, transferring glycosyl groups
H175_RS07955	COG0438	transferase activity, transferring glycosyl groups
H175_RS07970	COG0454	-acetyltransferase
H175_RS07990	COG0328	RNA-DNA hybrid ribonuclease activity
H175_RS07995	COG3344	reverse transcriptase
H175_RS08035	COG3403	YqcI/YcgG family
H175_RS08040	COG1280	lysine exporter protein (LysE YggA)
H175_RS08060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H175_RS08065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H175_RS08075	COG0475	glutathione-regulated potassium exporter activity
H175_RS08080	COG0789	Transcriptional regulator
H175_RS08080	COG4978	Transcriptional regulator
H175_RS08090	COG2323	membrane
H175_RS08095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H175_RS08155	COG1923	regulation of RNA biosynthetic process
H175_RS08165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H175_RS08170	COG1360	Flagellar Motor Protein
H175_RS08175	COG2201	protein-glutamate methylesterase activity
H175_RS08180	COG0643	Histidine kinase
H175_RS08180	COG2198	Histidine kinase
H175_RS08185	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H175_RS08185	COG1776	CheC inhibitor of MCP methylation
H175_RS08200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H175_RS08220	COG1256	bacterial-type flagellum assembly
H175_RS08225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H175_RS08245	COG1815	bacterial-type flagellum-dependent cell motility
H175_RS08250	COG1558	bacterial-type flagellum-dependent cell motility
H175_RS08260	COG1766	The M ring may be actively involved in energy transduction
H175_RS08265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H175_RS08275	COG1157	protein secretion by the type III secretion system
H175_RS08295	COG1749	Flagellar hook protein flgE
H175_RS08310	COG0784	Response regulator, receiver
H175_RS08310	COG0835	chemotaxis
H175_RS08320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H175_RS08325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H175_RS08330	COG0741	lytic transglycosylase activity
H175_RS08340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H175_RS08345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H175_RS08345	COG1776	CheC inhibitor of MCP methylation
H175_RS08355	COG1338	Plays a role in the flagellum-specific transport system
H175_RS08360	COG1987	bacterial-type flagellum assembly
H175_RS08370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H175_RS08375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H175_RS08380	COG1419	protein localization to endoplasmic reticulum
H175_RS08385	COG4786	Flagellar basal body rod
H175_RS08390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H175_RS08395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H175_RS08425	COG2329	Antibiotic biosynthesis monooxygenase
H175_RS08455	COG0583	DNA-binding transcription factor activity
H175_RS08460	COG3842	ATPase activity
H175_RS08470	COG1177	transmembrane transport
H175_RS08510	COG0406	alpha-ribazole phosphatase activity
H175_RS08540	COG0367	asparagine synthase
H175_RS08570	COG1802	Transcriptional regulator
H175_RS08575	COG0697	spore germination
H175_RS08585	COG0523	cobalamin synthesis protein
H175_RS08590	COG0701	Predicted permease
H175_RS08605	COG1757	Na H antiporter
H175_RS08610	COG0789	Transcriptional regulator
H175_RS08635	COG0534	Mate efflux family protein
H175_RS08640	COG3340	Belongs to the peptidase S51 family
H175_RS08660	COG0785	Cytochrome C biogenesis protein
H175_RS08665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H175_RS08675	COG0457	Tetratricopeptide repeat
H175_RS08695	COG2733	membrane
H175_RS08730	COG1131	(ABC) transporter
H175_RS08745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H175_RS08750	COG0528	UMP kinase activity
H175_RS08760	COG1027	Aspartate ammonia-lyase
H175_RS08765	COG0281	malic enzyme
H175_RS08770	COG4191	Histidine kinase
H175_RS08775	COG0784	Response regulator, receiver
H175_RS08780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H175_RS08840	COG1695	Transcriptional regulator
H175_RS08850	COG0477	Major facilitator Superfamily
H175_RS08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H175_RS08870	COG2223	nitrite transmembrane transporter activity
H175_RS08875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H175_RS08895	COG0733	neurotransmitter:sodium symporter activity
H175_RS08905	COG5566	PFAM Mor transcription activator
H175_RS08910	COG2323	membrane
H175_RS08930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H175_RS08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H175_RS08945	COG0028	Belongs to the TPP enzyme family
H175_RS08965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H175_RS08990	COG2814	Major facilitator Superfamily
H175_RS08995	COG3384	dioxygenase
H175_RS09005	COG3279	Response regulator of the LytR AlgR family
H175_RS09010	COG0427	acetyl-CoA hydrolase
H175_RS09030	COG2814	Major facilitator Superfamily
H175_RS09035	COG1309	transcriptional regulator
H175_RS09040	COG4166	transmembrane transport
H175_RS09045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS09070	COG1914	H( )-stimulated, divalent metal cation uptake system
H175_RS09085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H175_RS09095	COG0531	amino acid
H175_RS09120	COG2309	aminopeptidase activity
H175_RS09135	COG0456	acetyltransferase
H175_RS09145	COG1266	CAAX protease self-immunity
H175_RS09150	COG1309	transcriptional regulator
H175_RS09155	COG2390	Transcriptional regulator
H175_RS09165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS09170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H175_RS09180	COG4846	Membrane protein involved in cytochrome C biogenesis
H175_RS09200	COG0583	DNA-binding transcription factor activity
H175_RS09215	COG0006	proline dipeptidase activity
H175_RS09225	COG2132	Multicopper oxidase
H175_RS09235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H175_RS09255	COG1114	Component of the transport system for branched-chain amino acids
H175_RS09265	COG1276	copper resistance
H175_RS09265	COG2372	response to copper ion
H175_RS09270	COG4549	nuclear export factor GLE1
H175_RS09275	COG0697	spore germination
H175_RS09280	COG0583	DNA-binding transcription factor activity
H175_RS09285	COG1959	2 iron, 2 sulfur cluster binding
H175_RS09290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H175_RS09295	COG0778	Nitroreductase
H175_RS09305	COG0154	amidase activity
H175_RS09310	COG1396	sequence-specific DNA binding
H175_RS09330	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS09400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H175_RS09400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H175_RS09485	COG2002	toxin-antitoxin pair type II binding
H175_RS09520	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H175_RS09630	COG4824	toxin secretion phage lysis holin
H175_RS09720	COG0628	permease
H175_RS09730	COG1231	oxidoreductase activity
H175_RS09735	COG0523	cobalamin synthesis protein
H175_RS09745	COG0411	ABC transporter
H175_RS09765	COG0583	DNA-binding transcription factor activity
H175_RS09775	COG1942	4-Oxalocrotonate Tautomerase
H175_RS09795	COG1271	oxidase subunit
H175_RS09800	COG1294	oxidase, subunit
H175_RS09805	COG4988	ABC transporter
H175_RS09810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H175_RS09820	COG1216	Glycosyl transferase, family 2
H175_RS09860	COG1686	Belongs to the peptidase S11 family
H175_RS09875	COG1388	LysM domain
H175_RS09875	COG0791	NLP P60 protein
H175_RS09885	COG1132	(ABC) transporter
H175_RS09890	COG0745	RESPONSE REGULATOR receiver
H175_RS09895	COG5002	protein histidine kinase activity
H175_RS09905	COG0300	oxidoreductase activity
H175_RS09910	COG4122	O-methyltransferase activity
H175_RS09940	COG0460	homoserine dehydrogenase
H175_RS09965	COG1316	TRANSCRIPTIONal
H175_RS09975	COG0745	RESPONSE REGULATOR receiver
H175_RS09980	COG5002	protein histidine kinase activity
H175_RS09995	COG1285	pathogenesis
H175_RS10000	COG1247	-acetyltransferase
H175_RS10020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H175_RS10030	COG1082	Xylose isomerase domain protein TIM barrel
H175_RS10040	COG2814	Major facilitator Superfamily
H175_RS10045	COG1279	arginine transmembrane transporter activity
H175_RS10050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS10060	COG1752	Esterase of the alpha-beta hydrolase superfamily
H175_RS10095	COG0577	efflux transmembrane transporter activity
H175_RS10100	COG2002	toxin-antitoxin pair type II binding
H175_RS10105	COG1404	Belongs to the peptidase S8 family
H175_RS10110	COG0640	Transcriptional regulator
H175_RS10115	COG0667	Aldo Keto reductase
H175_RS10120	COG2814	Major facilitator Superfamily
H175_RS10145	COG0840	transmembrane signaling receptor activity
H175_RS10160	COG3949	Membrane
H175_RS10165	COG0783	Belongs to the Dps family
H175_RS10180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H175_RS10190	COG1231	oxidoreductase activity
H175_RS10195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS10200	COG4989	oxidoreductase activity
H175_RS10205	COG0523	cobalamin synthesis protein
H175_RS10210	COG0456	acetyltransferase
H175_RS10215	COG0803	Belongs to the bacterial solute-binding protein 9 family
H175_RS10220	COG0702	epimerase
H175_RS10240	COG4166	transmembrane transport
H175_RS10265	COG5337	Spore coat protein CotH
H175_RS10270	COG1051	belongs to the nudix hydrolase family
H175_RS10275	COG0586	Pfam SNARE associated Golgi protein
H175_RS10280	COG2244	polysaccharide biosynthetic process
H175_RS10290	COG0701	Predicted permease
H175_RS10295	COG3689	TIGRFAM TIGR03943 family protein
H175_RS10300	COG1607	acyl-coa hydrolase
H175_RS10305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H175_RS10320	COG0702	epimerase
H175_RS10325	COG2839	Protein conserved in bacteria
H175_RS10330	COG1253	flavin adenine dinucleotide binding
H175_RS10355	COG1114	Component of the transport system for branched-chain amino acids
H175_RS10360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H175_RS10375	COG0860	N-Acetylmuramoyl-L-alanine amidase
H175_RS10385	COG1876	peptidase activity
H175_RS10400	COG2211	Major facilitator Superfamily
H175_RS10425	COG0561	phosphatase activity
H175_RS10430	COG1846	Transcriptional regulator
H175_RS10435	COG2814	Major facilitator Superfamily
H175_RS10445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H175_RS10450	COG4106	trans-aconitate 2-methyltransferase activity
H175_RS10465	COG1819	glycosyl
H175_RS10470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS10475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS10505	COG0456	acetyltransferase
H175_RS10550	COG3874	Sporulation protein YtfJ
H175_RS10575	COG2226	methyltransferase
H175_RS10595	COG1082	Xylose isomerase domain protein TIM barrel
H175_RS10600	COG0346	lactoylglutathione lyase activity
H175_RS10610	COG0604	alcohol dehydrogenase
H175_RS10615	COG1595	DNA-templated transcription, initiation
H175_RS10630	COG0426	domain, Protein
H175_RS10630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H175_RS10640	COG0386	Belongs to the glutathione peroxidase family
H175_RS10645	COG1305	Transglutaminase-like
H175_RS10650	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
H175_RS10655	COG0714	Associated with various cellular activities
H175_RS10660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H175_RS10665	COG1140	nitrate reductase beta subunit
H175_RS10670	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
H175_RS10675	COG2181	nitrate reductase activity
H175_RS10680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H175_RS10685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H175_RS10690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H175_RS10695	COG0303	'Molybdopterin
H175_RS10700	COG0314	molybdopterin synthase activity
H175_RS10710	COG2223	nitrite transmembrane transporter activity
H175_RS10725	COG1648	precorrin-2 dehydrogenase activity
H175_RS10735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H175_RS10735	COG1587	Uroporphyrinogen-III synthase
H175_RS10740	COG2146	nitrite reductase [NAD(P)H] activity
H175_RS10745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H175_RS10750	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H175_RS10785	COG2359	stage V sporulation protein S
H175_RS10805	COG1418	mRNA catabolic process
H175_RS10810	COG0488	(ABC) transporter
H175_RS10825	COG0629	single-stranded DNA binding
H175_RS10835	COG1413	lyase activity
H175_RS10850	COG2521	methyltransferase
H175_RS10850	COG2136	Putative SAM-dependent methyltransferase
H175_RS10855	COG0018	arginyl-trna synthetase
H175_RS10895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H175_RS10900	COG0017	Asparaginyl-tRNA synthetase
H175_RS10920	COG1674	ftsk spoiiie
H175_RS10995	COG0733	neurotransmitter:sodium symporter activity
H175_RS11020	COG2610	gluconate transmembrane transporter activity
H175_RS11030	COG1794	racemase activity, acting on amino acids and derivatives
H175_RS11040	COG0456	acetyltransferase
H175_RS11050	COG3655	Transcriptional regulator
H175_RS11055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H175_RS11065	COG1131	(ABC) transporter
H175_RS11070	COG4473	ABC transporter
H175_RS11080	COG0546	phosphoglycolate phosphatase activity
H175_RS11090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H175_RS11105	COG0768	penicillin binding
H175_RS11115	COG0204	Acyl-transferase
H175_RS11120	COG1272	protein, Hemolysin III
H175_RS11130	COG0805	protein transport
H175_RS11140	COG1307	EDD domain protein, DegV family
H175_RS11150	COG1999	signal sequence binding
H175_RS11155	COG0071	Belongs to the small heat shock protein (HSP20) family
H175_RS11160	COG0367	asparagine synthase
H175_RS11175	COG0860	N-Acetylmuramoyl-L-alanine amidase
H175_RS11180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS11185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H175_RS11205	COG1335	isochorismatase
H175_RS11210	COG1051	belongs to the nudix hydrolase family
H175_RS11215	COG0668	transmembrane transport
H175_RS11220	COG4585	Histidine kinase
H175_RS11220	COG2203	Gaf domain
H175_RS11225	COG2197	response regulator
H175_RS11230	COG1737	Transcriptional regulator
H175_RS11235	COG0384	phenazine biosynthesis protein PhzF
H175_RS11240	COG1064	alcohol dehydrogenase
H175_RS11265	COG1070	Carbohydrate kinase
H175_RS11275	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H175_RS11310	COG0517	IMP dehydrogenase activity
H175_RS11310	COG1125	glycine betaine transport
H175_RS11315	COG1174	glycine betaine transport
H175_RS11350	COG1253	flavin adenine dinucleotide binding
H175_RS11355	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS11360	COG5506	Protein of unknown function (DUF1694)
H175_RS11375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H175_RS11380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H175_RS11385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H175_RS11390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H175_RS11395	COG0456	acetyltransferase
H175_RS11400	COG3829	transcription factor binding
H175_RS11405	COG1509	lysine 2,3-aminomutase activity
H175_RS11435	COG3064	Membrane
H175_RS11435	COG4991	sh3 domain protein
H175_RS11435	COG0515	serine threonine protein kinase
H175_RS11445	COG0671	phosphoesterase, PA-phosphatase related
H175_RS11450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H175_RS11455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H175_RS11525	COG0300	oxidoreductase activity
H175_RS11545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H175_RS11545	COG4499	WXG100 protein secretion system (Wss), protein YukC
H175_RS11555	COG2814	Major facilitator Superfamily
H175_RS11560	COG4841	protein insertion into membrane
H175_RS11565	COG0372	Belongs to the citrate synthase family
H175_RS11570	COG2079	MmgE PrpD family protein
H175_RS11575	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H175_RS11580	COG1960	acyl-CoA dehydrogenase activity
H175_RS11585	COG2084	Dehydrogenase
H175_RS11595	COG1280	lysine exporter protein (LysE YggA)
H175_RS11600	COG1024	Enoyl-CoA hydratase
H175_RS11615	COG0420	3'-5' exonuclease activity
H175_RS11620	COG0419	ATPase involved in DNA repair
H175_RS11640	COG2223	nitrite transmembrane transporter activity
H175_RS11645	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS11650	COG1169	isochorismate synthase
H175_RS11655	COG1021	2,3-dihydroxybenzoate-AMP ligase
H175_RS11660	COG1535	isochorismatase
H175_RS11660	COG3433	isochorismatase activity
H175_RS11665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H175_RS11670	COG3251	PFAM MbtH domain protein
H175_RS11675	COG2814	Major facilitator Superfamily
H175_RS11690	COG0776	regulation of translation
H175_RS11700	COG2318	DinB family
H175_RS11710	COG1115	amino acid carrier protein
H175_RS11730	COG1187	pseudouridine synthase activity
H175_RS11735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H175_RS11740	COG1136	(ABC) transporter
H175_RS11750	COG2814	Major facilitator Superfamily
H175_RS11765	COG0028	Belongs to the TPP enzyme family
H175_RS11775	COG1234	tRNA 3'-trailer cleavage
H175_RS11800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H175_RS11815	COG1846	Transcriptional regulator
H175_RS11825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS11860	COG1247	-acetyltransferase
H175_RS11885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H175_RS11895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS11925	COG0583	DNA-binding transcription factor activity
H175_RS11930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H175_RS11950	COG0583	DNA-binding transcription factor activity
H175_RS11955	COG2258	MOSC domain
H175_RS11970	COG1132	(ABC) transporter
H175_RS11975	COG1132	(ABC) transporter
H175_RS12015	COG0582	viral genome integration into host DNA
H175_RS12045	COG5484	DNA packaging
H175_RS12060	COG5632	N-Acetylmuramoyl-L-alanine amidase
H175_RS12090	COG1396	sequence-specific DNA binding
H175_RS12120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H175_RS12125	COG1595	DNA-templated transcription, initiation
H175_RS12150	COG1649	PFAM Uncharacterised BCR, COG1649
H175_RS12175	COG2971	BadF BadG BcrA BcrD
H175_RS12195	COG1846	Transcriptional regulator
H175_RS12210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS12245	COG3615	Tellurite resistance protein tehB
H175_RS12245	COG0500	methyltransferase
H175_RS12255	COG2226	methyltransferase
H175_RS12260	COG3961	Belongs to the TPP enzyme family
H175_RS12265	COG1846	Transcriptional regulator
H175_RS12305	COG2195	Cleaves the N-terminal amino acid of tripeptides
H175_RS12335	COG2002	toxin-antitoxin pair type II binding
H175_RS12345	COG0730	response to heat
H175_RS12350	COG0110	maltose O-acetyltransferase activity
H175_RS12355	COG1686	Belongs to the peptidase S11 family
H175_RS12370	COG2814	Major facilitator Superfamily
H175_RS12405	COG1115	amino acid carrier protein
H175_RS12410	COG2066	Belongs to the glutaminase family
H175_RS12415	COG4191	Histidine kinase
H175_RS12420	COG0784	Response regulator, receiver
H175_RS12425	COG0697	spore germination
H175_RS12430	COG0531	amino acid
H175_RS12440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H175_RS12445	COG0531	amino acid
H175_RS12450	COG0322	excinuclease ABC activity
H175_RS12455	COG2207	Transcriptional regulator
H175_RS12485	COG5002	protein histidine kinase activity
H175_RS12495	COG2267	carboxylic ester hydrolase activity
H175_RS12545	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS12555	COG0768	penicillin binding
H175_RS12560	COG1595	DNA-templated transcription, initiation
H175_RS12570	COG0768	penicillin binding
H175_RS12575	COG0768	penicillin binding
H175_RS12590	COG1408	metallophosphoesterase
H175_RS12600	COG1131	(ABC) transporter
H175_RS12610	COG1309	transcriptional regulator
H175_RS12625	COG1960	acyl-CoA dehydrogenase activity
H175_RS12630	COG0439	Biotin carboxylase
H175_RS12635	COG0511	ligase activity, forming carbon-carbon bonds
H175_RS12640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H175_RS12645	COG1024	Enoyl-CoA hydratase
H175_RS12650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H175_RS12655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H175_RS12665	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS12685	COG1686	Belongs to the peptidase S11 family
H175_RS12710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H175_RS12725	COG3227	Zinc metalloprotease (Elastase)
H175_RS12730	COG2207	Transcriptional regulator
H175_RS12760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H175_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS12790	COG1733	regulation of RNA biosynthetic process
H175_RS12830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS12840	COG2368	4-hydroxyphenylacetate
H175_RS12855	COG1063	alcohol dehydrogenase
H175_RS12865	COG2323	membrane
H175_RS12875	COG0693	protein deglycase activity
H175_RS12885	COG3386	PFAM SMP-30 Gluconolaconase
H175_RS12890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
H175_RS12895	COG3773	Cell wall hydrolase
H175_RS12905	COG0745	RESPONSE REGULATOR receiver
H175_RS12910	COG2205	protein histidine kinase activity
H175_RS12925	COG0488	(ABC) transporter
H175_RS12940	COG1136	(ABC) transporter
H175_RS12945	COG0577	efflux transmembrane transporter activity
H175_RS12965	COG0460	homoserine dehydrogenase
H175_RS12970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS12980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H175_RS13005	COG0582	viral genome integration into host DNA
H175_RS13060	COG1484	DNA-dependent DNA replication
H175_RS13080	COG2002	toxin-antitoxin pair type II binding
H175_RS13090	COG2002	toxin-antitoxin pair type II binding
H175_RS13150	COG0582	viral genome integration into host DNA
H175_RS13185	COG5484	DNA packaging
H175_RS13200	COG0740	serine-type endopeptidase activity
H175_RS13260	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS13325	COG2124	cytochrome p450
H175_RS13360	COG0561	phosphatase activity
H175_RS13365	COG5002	protein histidine kinase activity
H175_RS13370	COG0768	penicillin binding
H175_RS13380	COG1819	glycosyl
H175_RS13385	COG1794	racemase activity, acting on amino acids and derivatives
H175_RS13405	COG2205	protein histidine kinase activity
H175_RS13465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H175_RS13470	COG0604	alcohol dehydrogenase
H175_RS13475	COG0671	phosphoesterase, PA-phosphatase related
H175_RS13480	COG0768	penicillin binding
H175_RS13530	COG0789	Transcriptional regulator
H175_RS13535	COG2814	Major facilitator Superfamily
H175_RS13550	COG0584	glycerophosphoryl diester phosphodiesterase
H175_RS13570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS13575	COG0697	spore germination
H175_RS13610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H175_RS13620	COG2223	nitrite transmembrane transporter activity
H175_RS13635	COG0592	DNA-directed DNA polymerase activity
H175_RS13670	COG3878	Protein conserved in bacteria
H175_RS13695	COG4667	esterase of the alpha-beta hydrolase superfamily
H175_RS13735	COG0322	excinuclease ABC activity
H175_RS13775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H175_RS13805	COG1011	Hydrolase
H175_RS13810	COG0745	RESPONSE REGULATOR receiver
H175_RS13815	COG5002	protein histidine kinase activity
H175_RS13825	COG3813	Protein conserved in bacteria
H175_RS13830	COG1522	sequence-specific DNA binding
H175_RS13845	COG1136	(ABC) transporter
H175_RS13850	COG0577	efflux transmembrane transporter activity
H175_RS13855	COG1073	alpha beta
H175_RS13860	COG0657	acetylesterase activity
H175_RS13865	COG0076	glutamate decarboxylase activity
H175_RS13880	COG1523	belongs to the glycosyl hydrolase 13 family
H175_RS13885	COG3227	Zinc metalloprotease (Elastase)
H175_RS13890	COG0737	Belongs to the 5'-nucleotidase family
H175_RS13905	COG0201	protein transport
H175_RS13920	COG0697	spore germination
H175_RS13925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS13935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H175_RS13965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS13980	COG2959	enzyme of heme biosynthesis
H175_RS14020	COG1309	transcriptional regulator
H175_RS14045	COG3284	Transcriptional regulator
H175_RS14065	COG1349	DNA-binding transcription factor activity
H175_RS14080	COG1959	2 iron, 2 sulfur cluster binding
H175_RS14095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H175_RS14100	COG0508	dehydrogenase complex catalyzes the overall conversion of
H175_RS14105	COG0022	dehydrogenase e1 component
H175_RS14110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H175_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS14125	COG0456	acetyltransferase
H175_RS14125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H175_RS14160	COG4176	ABC-type proline glycine betaine transport system permease component
H175_RS14165	COG4175	Glycine betaine
H175_RS14165	COG0517	IMP dehydrogenase activity
H175_RS14195	COG2153	protein acetylation
H175_RS14200	COG3397	chitin binding
H175_RS14205	COG1819	glycosyl
H175_RS14220	COG2205	protein histidine kinase activity
H175_RS14230	COG2315	Protein conserved in bacteria
H175_RS14280	COG0456	acetyltransferase
H175_RS14285	COG3973	AAA domain
H175_RS14295	COG2801	Transposase and inactivated derivatives
H175_RS14315	COG0514	ATP-dependent DNA helicase (RecQ)
H175_RS14340	COG4637	Psort location Cytoplasmic, score
H175_RS14360	COG3397	chitin binding
H175_RS14375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H175_RS14380	COG1115	amino acid carrier protein
H175_RS14385	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS14390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H175_RS14400	COG3938	Belongs to the proline racemase family
H175_RS14405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H175_RS14450	COG1078	dGTPase activity
H175_RS14455	COG0586	Pfam SNARE associated Golgi protein
H175_RS14465	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H175_RS14475	COG4166	transmembrane transport
H175_RS14485	COG4948	Mandelate Racemase Muconate Lactonizing
H175_RS14500	COG0667	Aldo Keto reductase
H175_RS14540	COG3850	Histidine kinase
H175_RS14540	COG5002	protein histidine kinase activity
H175_RS14545	COG0745	RESPONSE REGULATOR receiver
H175_RS14580	COG1164	Oligoendopeptidase f
H175_RS14585	COG1307	EDD domain protein, DegV family
H175_RS14610	COG2814	Major facilitator Superfamily
H175_RS14620	COG1664	Polymer-forming cytoskeletal
H175_RS14625	COG0789	Transcriptional regulator
H175_RS14630	COG4533	DNA binding
H175_RS14635	COG2814	Major facilitator Superfamily
H175_RS14635	COG0477	Major facilitator Superfamily
H175_RS14660	COG2261	transglycosylase associated protein
H175_RS14675	COG2226	methyltransferase
H175_RS14710	COG0436	Aminotransferase
H175_RS14715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H175_RS14725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H175_RS14740	COG1131	(ABC) transporter
H175_RS14790	COG0628	permease
H175_RS14805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H175_RS14810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H175_RS14850	COG2746	aminoglycoside 3-N-acetyltransferase activity
H175_RS14860	COG0697	spore germination
H175_RS14870	COG2318	DinB family
H175_RS14890	COG4912	Dna alkylation repair
H175_RS14895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H175_RS14900	COG0346	lactoylglutathione lyase activity
H175_RS14905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS14925	COG0861	Integral membrane protein TerC family
H175_RS14930	COG1368	sulfuric ester hydrolase activity
H175_RS14935	COG0488	(ABC) transporter
H175_RS14940	COG2409	Drug exporters of the RND superfamily
H175_RS14940	COG1033	growth of symbiont in host cell
H175_RS14945	COG1309	transcriptional regulator
H175_RS14960	COG0287	Prephenate dehydrogenase
H175_RS14975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H175_RS14975	COG1605	Chorismate mutase
H175_RS15020	COG3584	3D domain protein
H175_RS15020	COG1388	LysM domain
H175_RS15030	COG0277	FAD linked oxidase domain protein
H175_RS15055	COG1879	ABC-type sugar transport system periplasmic component
H175_RS15060	COG1172	Belongs to the binding-protein-dependent transport system permease family
H175_RS15065	COG1172	Belongs to the binding-protein-dependent transport system permease family
H175_RS15075	COG1129	ABC transporter
H175_RS15080	COG2390	Transcriptional regulator
H175_RS15085	COG1070	Carbohydrate kinase
H175_RS15105	COG2329	Antibiotic biosynthesis monooxygenase
H175_RS15115	COG0640	Transcriptional regulator
H175_RS15120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS15135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H175_RS15140	COG4187	Peptidase family M20/M25/M40
H175_RS15145	COG1414	Transcriptional regulator
H175_RS15150	COG0833	amino acid
H175_RS15170	COG0825	malonyl-CoA metabolic process
H175_RS15180	COG3239	Fatty acid desaturase
H175_RS15190	COG2720	vancomycin resistance protein
H175_RS15195	COG1785	Belongs to the alkaline phosphatase family
H175_RS15205	COG3655	Transcriptional regulator
H175_RS15225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS15230	COG0346	lactoylglutathione lyase activity
H175_RS15250	COG0714	Associated with various cellular activities
H175_RS15270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H175_RS15275	COG0753	catalase activity
H175_RS15310	COG0778	Nitroreductase
H175_RS15315	COG1846	Transcriptional regulator
H175_RS15335	COG3831	ATPase activity
H175_RS15335	COG4884	unkown
H175_RS15370	COG0456	acetyltransferase
H175_RS15385	COG0697	spore germination
H175_RS15390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS15435	COG0730	response to heat
H175_RS15445	COG0833	amino acid
H175_RS15455	COG4335	DNA alkylation repair
H175_RS15465	COG5002	protein histidine kinase activity
H175_RS15470	COG0745	RESPONSE REGULATOR receiver
H175_RS15480	COG0577	efflux transmembrane transporter activity
H175_RS15480	COG1136	(ABC) transporter
H175_RS15515	COG0768	penicillin binding
H175_RS15545	COG1984	allophanate hydrolase subunit 2
H175_RS15550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H175_RS15555	COG1414	Transcriptional regulator
H175_RS15570	COG3142	Participates in the control of copper homeostasis
H175_RS15575	COG0640	Transcriptional regulator
H175_RS15585	COG1960	acyl-CoA dehydrogenase activity
H175_RS15600	COG3314	Sporulation integral membrane protein YlbJ
H175_RS15620	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
H175_RS15655	COG0737	Belongs to the 5'-nucleotidase family
H175_RS15660	COG2267	carboxylic ester hydrolase activity
H175_RS15665	COG1335	isochorismatase
H175_RS15685	COG0583	DNA-binding transcription factor activity
H175_RS15690	COG1846	Transcriptional regulator
H175_RS15695	COG0598	Magnesium transport protein CorA
H175_RS15740	COG0814	amino acid
H175_RS15765	COG0415	Belongs to the DNA photolyase family
H175_RS15770	COG0288	reversible hydration of carbon dioxide
H175_RS15780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H175_RS15785	COG5609	conserved protein (DUF2294)
H175_RS15795	COG0456	acetyltransferase
H175_RS15800	COG1575	Belongs to the MenA family. Type 1 subfamily
H175_RS15810	COG0798	PFAM Bile acid sodium symporter
H175_RS15815	COG0346	lactoylglutathione lyase activity
H175_RS15820	COG0640	Transcriptional regulator
H175_RS15830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H175_RS15840	COG3320	Male sterility
H175_RS15840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H175_RS15845	COG1309	transcriptional regulator
H175_RS15895	COG2814	Major facilitator Superfamily
H175_RS15900	COG1309	transcriptional regulator
H175_RS15905	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS15910	COG1522	sequence-specific DNA binding
H175_RS15925	COG0346	lactoylglutathione lyase activity
H175_RS15995	COG0745	RESPONSE REGULATOR receiver
H175_RS16000	COG3850	Histidine kinase
H175_RS16000	COG5002	protein histidine kinase activity
H175_RS16040	COG1136	(ABC) transporter
H175_RS16080	COG2814	Major facilitator Superfamily
H175_RS16100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H175_RS16125	COG1690	Belongs to the RtcB family
H175_RS16135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H175_RS16150	COG0277	FAD linked oxidase domain protein
H175_RS16160	COG0577	efflux transmembrane transporter activity
H175_RS16180	COG3850	Histidine kinase
H175_RS16180	COG5002	protein histidine kinase activity
H175_RS16190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS16205	COG1619	proteins homologs of microcin C7 resistance protein MccF
H175_RS16225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H175_RS16245	COG0662	Cupin 2, conserved barrel domain protein
H175_RS16250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS16250	COG2207	Transcriptional regulator
H175_RS16265	COG5632	N-Acetylmuramoyl-L-alanine amidase
H175_RS16265	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS16285	COG1876	peptidase activity
H175_RS16290	COG2843	Capsule synthesis protein
H175_RS16300	COG0477	Major facilitator Superfamily
H175_RS16315	COG1846	Transcriptional regulator
H175_RS16320	COG2814	Major facilitator Superfamily
H175_RS16340	COG2031	fatty acid transporter
H175_RS16350	COG2249	NAD(P)H dehydrogenase (quinone) activity
H175_RS16405	COG1288	antiporter activity
H175_RS16410	COG2356	endonuclease I
H175_RS16420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H175_RS16430	COG3620	sequence-specific DNA binding
H175_RS16445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H175_RS16465	COG1733	regulation of RNA biosynthetic process
H175_RS16470	COG0778	Nitroreductase
H175_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS16510	COG1131	(ABC) transporter
H175_RS16535	COG1011	Hydrolase
H175_RS16545	COG2365	Tyrosine phosphatase family
H175_RS16570	COG0346	lactoylglutathione lyase activity
H175_RS16575	COG1940	carbohydrate kinase activity
H175_RS16585	COG0110	maltose O-acetyltransferase activity
H175_RS16600	COG0628	permease
H175_RS16625	COG0500	methyltransferase
H175_RS16635	COG0477	Major facilitator Superfamily
H175_RS16660	COG1253	flavin adenine dinucleotide binding
H175_RS16665	COG0789	Transcriptional regulator
H175_RS16675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H175_RS16700	COG0697	spore germination
H175_RS16710	COG1357	PFAM Pentapeptide repeats (8 copies)
H175_RS16715	COG3813	Protein conserved in bacteria
H175_RS16720	COG2706	6-phosphogluconolactonase activity
H175_RS16725	COG1070	Carbohydrate kinase
H175_RS16740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H175_RS16745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H175_RS16750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H175_RS16755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H175_RS16760	COG0604	alcohol dehydrogenase
H175_RS16765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H175_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS16790	COG0840	transmembrane signaling receptor activity
H175_RS16800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H175_RS16800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H175_RS16805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H175_RS16805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H175_RS16810	COG1733	regulation of RNA biosynthetic process
H175_RS16825	COG0656	L-ascorbic acid biosynthetic process
H175_RS16830	COG2814	Major facilitator Superfamily
H175_RS16850	COG2824	Alkylphosphonate utilization operon protein PhnA
H175_RS16855	COG0659	secondary active sulfate transmembrane transporter activity
H175_RS16870	COG0814	amino acid
H175_RS16905	COG1733	regulation of RNA biosynthetic process
H175_RS16910	COG2188	Transcriptional regulator
H175_RS16920	COG0673	inositol 2-dehydrogenase activity
H175_RS16925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H175_RS16930	COG1733	regulation of RNA biosynthetic process
H175_RS16935	COG1733	regulation of RNA biosynthetic process
H175_RS16960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS16985	COG0384	phenazine biosynthesis protein PhzF
H175_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS17005	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS17010	COG2249	NAD(P)H dehydrogenase (quinone) activity
H175_RS17015	COG1733	regulation of RNA biosynthetic process
H175_RS17025	COG0726	polysaccharide deacetylase
H175_RS17035	COG1191	sigma factor activity
H175_RS17045	COG1280	lysine exporter protein (LysE YggA)
H175_RS17095	COG1151	hydroxylamine reductase activity
H175_RS17105	COG3757	hydrolase, family 25
H175_RS17105	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS17140	COG2072	flavoprotein involved in K transport
H175_RS17175	COG1113	amino acid transport
H175_RS17180	COG2814	Major facilitator Superfamily
H175_RS17210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H175_RS17215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H175_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS17235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS17240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS17245	COG3739	integral membrane protein
H175_RS17275	COG0583	DNA-binding transcription factor activity
H175_RS17295	COG1193	negative regulation of DNA recombination
H175_RS17310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H175_RS17315	COG1164	Oligoendopeptidase f
H175_RS17335	COG3781	membrane
H175_RS17350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H175_RS17375	COG0584	glycerophosphoryl diester phosphodiesterase
H175_RS17390	COG0640	Transcriptional regulator
H175_RS17395	COG0604	alcohol dehydrogenase
H175_RS17405	COG0457	Tetratricopeptide repeat
H175_RS17415	COG2808	Putative FMN-binding domain
H175_RS17420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H175_RS17430	COG0277	FAD linked oxidase domain protein
H175_RS17440	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS17460	COG0823	Involved in the tonB-independent uptake of proteins
H175_RS17465	COG3397	chitin binding
H175_RS17475	COG0697	spore germination
H175_RS17520	COG0488	(ABC) transporter
H175_RS17525	COG1309	transcriptional regulator
H175_RS17540	COG1876	peptidase activity
H175_RS17565	COG3852	Histidine kinase
H175_RS17575	COG1285	pathogenesis
H175_RS17590	COG2514	catechol 2,3-dioxygenase activity
H175_RS17595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS17600	COG1126	abc transporter atp-binding protein
H175_RS17605	COG0765	amino acid transport
H175_RS17610	COG2720	vancomycin resistance protein
H175_RS17645	COG0716	FMN binding
H175_RS17655	COG1051	belongs to the nudix hydrolase family
H175_RS17675	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS17685	COG0165	Argininosuccinate lyase
H175_RS17700	COG4145	pantothenate transmembrane transporter activity
H175_RS17710	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS17725	COG1657	PFAM Prenyltransferase squalene oxidase
H175_RS17730	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
H175_RS17735	COG2962	Rard protein
H175_RS17740	COG3326	Membrane
H175_RS17755	COG0489	protein tyrosine kinase activity
H175_RS17765	COG0314	molybdopterin synthase activity
H175_RS17770	COG0303	'Molybdopterin
H175_RS17775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H175_RS17780	COG2116	formate transmembrane transporter activity
H175_RS17790	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H175_RS17795	COG5609	conserved protein (DUF2294)
H175_RS17800	COG2427	Protein of unknown function (DUF1641)
H175_RS17805	COG3383	formate dehydrogenase (NAD+) activity
H175_RS17815	COG0697	spore germination
H175_RS17830	COG0531	amino acid
H175_RS17865	COG2226	methyltransferase
H175_RS17870	COG4166	transmembrane transport
H175_RS17875	COG2801	Transposase and inactivated derivatives
H175_RS17885	COG4166	transmembrane transport
H175_RS17890	COG4166	transmembrane transport
H175_RS17895	COG1316	TRANSCRIPTIONal
H175_RS17905	COG1595	DNA-templated transcription, initiation
H175_RS17915	COG1131	(ABC) transporter
H175_RS17935	COG0673	inositol 2-dehydrogenase activity
H175_RS17940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS17945	COG0187	DNA topoisomerase II activity
H175_RS17950	COG1832	CoA-binding protein
H175_RS17955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H175_RS17960	COG0745	RESPONSE REGULATOR receiver
H175_RS17970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H175_RS17970	COG1328	CTP reductase activity
H175_RS17980	COG4841	protein insertion into membrane
H175_RS17985	COG0824	Thioesterase
H175_RS18015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H175_RS18025	COG2274	protein secretion by the type I secretion system
H175_RS18030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H175_RS18060	COG2211	Major facilitator Superfamily
H175_RS18070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H175_RS18085	COG0183	Belongs to the thiolase family
H175_RS18090	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS18095	COG1268	BioY protein
H175_RS18100	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS18105	COG1396	sequence-specific DNA binding
H175_RS18140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS18150	COG5002	protein histidine kinase activity
H175_RS18155	COG0400	carboxylic ester hydrolase activity
H175_RS18160	COG0346	lactoylglutathione lyase activity
H175_RS18165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H175_RS18170	COG0069	glutamate synthase activity
H175_RS18175	COG1902	pentaerythritol trinitrate reductase activity
H175_RS18180	COG1329	Transcriptional regulator
H175_RS18185	COG0010	Belongs to the arginase family
H175_RS18210	COG2226	methyltransferase
H175_RS18235	COG4846	Membrane protein involved in cytochrome C biogenesis
H175_RS18240	COG0785	Cytochrome C biogenesis protein
H175_RS18250	COG1473	amidohydrolase
H175_RS18260	COG1131	(ABC) transporter
H175_RS18275	COG0583	DNA-binding transcription factor activity
H175_RS18285	COG1346	cytolysis
H175_RS18300	COG0730	response to heat
H175_RS18325	COG1132	(ABC) transporter
H175_RS18330	COG1132	(ABC) transporter
H175_RS18365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS18370	COG0737	Belongs to the 5'-nucleotidase family
H175_RS18380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H175_RS18400	COG1695	Transcriptional regulator
H175_RS18405	COG0174	glutamine synthetase
H175_RS18410	COG0789	Transcriptional regulator
H175_RS18415	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H175_RS18420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H175_RS18425	COG2860	membrane
H175_RS18435	COG0464	growth
H175_RS18450	COG2801	Transposase and inactivated derivatives
H175_RS18475	COG3584	3D domain protein
H175_RS18475	COG1388	LysM domain
H175_RS18480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H175_RS18480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H175_RS18480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H175_RS18485	COG1105	Belongs to the carbohydrate kinase PfkB family
H175_RS18490	COG1349	DNA-binding transcription factor activity
H175_RS18495	COG1979	alcohol dehydrogenase
H175_RS18500	COG2322	membrane
H175_RS18515	COG1113	amino acid transport
H175_RS18525	COG1408	metallophosphoesterase
H175_RS18530	COG2116	formate transmembrane transporter activity
H175_RS18545	COG2217	Heavy metal translocating P-type atpase
H175_RS18550	COG2608	mercury ion transmembrane transporter activity
H175_RS18555	COG1937	Protein conserved in bacteria
H175_RS18575	COG2819	hydrolase of the alpha beta superfamily
H175_RS18580	COG1120	ATPase activity
H175_RS18585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS18590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS18595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS18600	COG0708	Exodeoxyribonuclease III
H175_RS18605	COG2169	Transcriptional regulator
H175_RS18610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H175_RS18615	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H175_RS18625	COG2364	Membrane
H175_RS18640	COG2267	carboxylic ester hydrolase activity
H175_RS18645	COG3300	MHYT domain
H175_RS18645	COG5001	Diguanylate cyclase
H175_RS18665	COG1086	Polysaccharide biosynthesis protein
H175_RS18680	COG1346	cytolysis
H175_RS18690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H175_RS18700	COG2188	Transcriptional regulator
H175_RS18705	COG2723	6-phospho-beta-galactosidase activity
H175_RS18715	COG1404	Belongs to the peptidase S8 family
H175_RS18720	COG3773	Cell wall hydrolase
H175_RS18730	COG1368	sulfuric ester hydrolase activity
H175_RS18735	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H175_RS18760	COG4550	Control of competence regulator ComK, YlbF/YmcA
H175_RS18770	COG1013	pyruvate-flavodoxin oxidoreductase activity
H175_RS18775	COG0674	pyruvate-flavodoxin oxidoreductase activity
H175_RS18775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H175_RS18785	COG2359	stage V sporulation protein S
H175_RS18790	COG1692	metallophosphoesterase
H175_RS18815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H175_RS18820	COG1426	Protein conserved in bacteria
H175_RS18835	COG0300	oxidoreductase activity
H175_RS18840	COG0612	Peptidase, M16
H175_RS18845	COG0612	Peptidase, M16
H175_RS18850	COG1079	Belongs to the binding-protein-dependent transport system permease family
H175_RS18855	COG4603	Belongs to the binding-protein-dependent transport system permease family
H175_RS18860	COG3845	ABC transporter
H175_RS18865	COG1744	ABC transporter substrate-binding protein PnrA-like
H175_RS18870	COG2188	Transcriptional regulator
H175_RS18890	COG0740	serine-type endopeptidase activity
H175_RS18895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H175_RS18905	COG0527	aspartate kinase activity
H175_RS18910	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H175_RS18915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H175_RS18925	COG5444	nuclease activity
H175_RS18950	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS19060	COG0582	viral genome integration into host DNA
H175_RS19105	COG0305	Participates in initiation and elongation during chromosome replication
H175_RS19140	COG1396	sequence-specific DNA binding
H175_RS19165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H175_RS19170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H175_RS19175	COG1873	PFAM PRC-barrel domain
H175_RS19180	COG0612	Peptidase, M16
H175_RS19185	COG0726	polysaccharide deacetylase
H175_RS19200	COG0196	riboflavin kinase activity
H175_RS19210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H175_RS19215	COG1550	Protein conserved in bacteria
H175_RS19225	COG1358	cellular component organization or biogenesis
H175_RS19230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H175_RS19235	COG0195	Participates in both transcription termination and antitermination
H175_RS19255	COG0750	zinc metalloprotease
H175_RS19265	COG4589	Belongs to the CDS family
H175_RS19310	COG4974	Belongs to the 'phage' integrase family
H175_RS19320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H175_RS19325	COG0758	DNA mediated transformation
H175_RS19330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H175_RS19370	COG1837	Belongs to the UPF0109 family
H175_RS19380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H175_RS19390	COG0552	protein localization to endoplasmic reticulum
H175_RS19395	COG1196	nuclear chromosome segregation
H175_RS19405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H175_RS19410	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS19415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H175_RS19430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H175_RS19435	COG1461	Dihydroxyacetone kinase
H175_RS19440	COG1302	Protein conserved in bacteria
H175_RS19455	COG1564	THIamine pyrophosphokinase
H175_RS19460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H175_RS19470	COG0515	serine threonine protein kinase
H175_RS19470	COG2815	serine threonine protein kinase
H175_RS19475	COG0631	protein serine/threonine phosphatase activity
H175_RS19485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H175_RS19485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H175_RS19500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H175_RS19505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H175_RS19525	COG1561	YicC-like family, N-terminal region
H175_RS19530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H175_RS19545	COG0006	proline dipeptidase activity
H175_RS19565	COG3069	C4-dicarboxylate transmembrane transporter activity
H175_RS19630	COG0564	pseudouridine synthase activity
H175_RS19650	COG3599	regulation of cell shape
H175_RS19655	COG2302	S4 RNA-binding domain
H175_RS19660	COG0762	integral membrane protein
H175_RS19670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H175_RS19680	COG1873	PFAM PRC-barrel domain
H175_RS19685	COG1191	sigma factor activity
H175_RS19690	COG1191	sigma factor activity
H175_RS19700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H175_RS19705	COG0849	cell division
H175_RS19725	COG0772	Belongs to the SEDS family
H175_RS19745	COG0768	penicillin binding
H175_RS19750	COG0768	penicillin binding
H175_RS19770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H175_RS19785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H175_RS19790	COG1399	metal-binding, possibly nucleic acid-binding protein
H175_RS19800	COG3480	Lon protease (S16) C-terminal proteolytic domain
H175_RS19805	COG1752	Esterase of the alpha-beta hydrolase superfamily
H175_RS19810	COG3314	Sporulation integral membrane protein YlbJ
H175_RS19820	COG0742	ribosomal rna small subunit methyltransferase
H175_RS19835	COG3679	Belongs to the UPF0342 family
H175_RS19840	COG0406	alpha-ribazole phosphatase activity
H175_RS19855	COG2340	Cysteine-rich secretory protein family
H175_RS19870	COG2801	Transposase and inactivated derivatives
H175_RS19880	COG3344	reverse transcriptase
H175_RS19890	COG3336	cytochrome c oxidase
H175_RS19925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
H175_RS19930	COG0772	Belongs to the SEDS family
H175_RS19940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H175_RS19945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H175_RS19955	COG4896	Protein conserved in bacteria
H175_RS19970	COG1217	gtp-binding protein TYPA
H175_RS19980	COG0483	inositol monophosphate 1-phosphatase activity
H175_RS20000	COG1982	Orn Lys Arg decarboxylase major
H175_RS20050	COG0022	dehydrogenase e1 component
H175_RS20055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H175_RS20070	COG0561	phosphatase activity
H175_RS20080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H175_RS20085	COG0569	domain protein
H175_RS20105	COG0583	DNA-binding transcription factor activity
H175_RS20110	COG0517	IMP dehydrogenase activity
H175_RS20120	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
H175_RS20130	COG4703	Protein of unknown function (DUF1797)
H175_RS20145	COG2200	EAL domain
H175_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS20155	COG1408	metallophosphoesterase
H175_RS20200	COG2814	Major facilitator Superfamily
H175_RS20220	COG3209	COG3209 Rhs family protein
H175_RS20230	COG2205	protein histidine kinase activity
H175_RS20240	COG0436	Aminotransferase
H175_RS20245	COG1609	Transcriptional regulator
H175_RS20250	COG3833	ABC-type maltose transport systems, permease component
H175_RS20255	COG1175	transmembrane transport
H175_RS20260	COG2182	Extracellular solute-binding protein
H175_RS20270	COG0366	Alpha amylase catalytic
H175_RS20275	COG3842	ATPase activity
H175_RS20315	COG0183	Belongs to the thiolase family
H175_RS20345	COG1695	Transcriptional regulator
H175_RS20350	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS20370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H175_RS20375	COG0436	Aminotransferase
H175_RS20410	COG2084	Dehydrogenase
H175_RS20420	COG2199	diguanylate cyclase activity
H175_RS20425	COG0778	Nitroreductase
H175_RS20450	COG1263	PTS System
H175_RS20450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H175_RS20450	COG2190	(PTS) system
H175_RS20455	COG3711	transcriptional antiterminator
H175_RS20465	COG2188	Transcriptional regulator
H175_RS20475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H175_RS20495	COG1547	Domain of unknown function (DUF309)
H175_RS20500	COG0456	acetyltransferase
H175_RS20505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H175_RS20510	COG4086	secreted protein
H175_RS20515	COG0561	phosphatase activity
H175_RS20520	COG0697	spore germination
H175_RS20535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H175_RS20560	COG0733	neurotransmitter:sodium symporter activity
H175_RS20580	COG1686	Belongs to the peptidase S11 family
H175_RS20585	COG1725	Transcriptional regulator
H175_RS20590	COG1131	(ABC) transporter
H175_RS20610	COG1846	Transcriptional regulator
H175_RS20625	COG0598	Magnesium transport protein CorA
H175_RS20650	COG4974	Belongs to the 'phage' integrase family
H175_RS20660	COG0735	belongs to the Fur family
H175_RS20665	COG1300	Membrane
H175_RS20685	COG0667	Aldo Keto reductase
H175_RS20690	COG0656	L-ascorbic acid biosynthetic process
H175_RS20695	COG0456	acetyltransferase
H175_RS20695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H175_RS20705	COG0737	Belongs to the 5'-nucleotidase family
H175_RS20705	COG1525	nuclease
H175_RS20705	COG4085	toxin activity
H175_RS20715	COG0596	Alpha beta hydrolase
H175_RS20720	COG2056	Na+-H+ antiporter family
H175_RS20725	COG1609	Transcriptional regulator
H175_RS20730	COG0456	acetyltransferase
H175_RS20735	COG1073	alpha beta
H175_RS20750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H175_RS20750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H175_RS20755	COG0307	riboflavin synthase, alpha
H175_RS20785	COG1073	alpha beta
H175_RS20785	COG2226	methyltransferase
H175_RS20800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H175_RS20810	COG1757	Na H antiporter
H175_RS20815	COG0737	Belongs to the 5'-nucleotidase family
H175_RS20825	COG1522	sequence-specific DNA binding
H175_RS20865	COG5444	nuclease activity
H175_RS20900	COG0300	oxidoreductase activity
H175_RS20905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS20910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H175_RS20915	COG1760	l-serine dehydratase
H175_RS20920	COG1760	l-serine dehydratase
H175_RS20950	COG1285	pathogenesis
H175_RS20965	COG2195	Cleaves the N-terminal amino acid of tripeptides
H175_RS20970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS20980	COG1376	ErfK ybiS ycfS ynhG family protein
H175_RS20985	COG4129	membrane
H175_RS20990	COG1126	abc transporter atp-binding protein
H175_RS20995	COG0765	amino acid transport
H175_RS21000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H175_RS21020	COG2323	membrane
H175_RS21025	COG0772	Belongs to the SEDS family
H175_RS21030	COG0508	dehydrogenase complex catalyzes the overall conversion of
H175_RS21035	COG0022	dehydrogenase e1 component
H175_RS21040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H175_RS21045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H175_RS21060	COG0280	phosphate acetyltransferase
H175_RS21065	COG3829	transcription factor binding
H175_RS21065	COG3290	protein histidine kinase activity
H175_RS21075	COG0584	glycerophosphoryl diester phosphodiesterase
H175_RS21080	COG3093	addiction module antidote protein HigA
H175_RS21095	COG0750	zinc metalloprotease
H175_RS21100	COG0497	DNA recombination
H175_RS21110	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H175_RS21120	COG0142	geranyltranstransferase activity
H175_RS21145	COG1302	Protein conserved in bacteria
H175_RS21150	COG0439	Biotin carboxylase
H175_RS21155	COG0511	ligase activity, forming carbon-carbon bonds
H175_RS21195	COG3854	ATPases associated with a variety of cellular activities
H175_RS21220	COG0006	proline dipeptidase activity
H175_RS21235	COG3872	metal-dependent enzyme
H175_RS21245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H175_RS21280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H175_RS21290	COG1609	Transcriptional regulator
H175_RS21300	COG2076	Multidrug Resistance protein
H175_RS21305	COG2076	Multidrug Resistance protein
H175_RS21340	COG1725	Transcriptional regulator
H175_RS21370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H175_RS21435	COG1459	type II secretion system
H175_RS21440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H175_RS21505	COG1410	methionine synthase
H175_RS21505	COG0646	methionine synthase
H175_RS21510	COG0646	methionine synthase
H175_RS21510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H175_RS21515	COG0626	cystathionine gamma-synthase activity
H175_RS21520	COG0626	cystathionine gamma-synthase activity
H175_RS21540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS21550	COG1940	carbohydrate kinase activity
H175_RS21555	COG4483	Protein conserved in bacteria
H175_RS21560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H175_RS21565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H175_RS21570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H175_RS21575	COG0704	Plays a role in the regulation of phosphate uptake
H175_RS21585	COG0573	inorganic phosphate transmembrane transporter activity
H175_RS21590	COG0573	inorganic phosphate transmembrane transporter activity
H175_RS21595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H175_RS21600	COG0768	penicillin binding
H175_RS21605	COG0477	Major facilitator Superfamily
H175_RS21610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H175_RS21620	COG5521	maltodextrose utilization protein MalA
H175_RS21635	COG0735	belongs to the Fur family
H175_RS21640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H175_RS21645	COG1121	(ABC) transporter
H175_RS21650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS21680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H175_RS21685	COG2384	SAM-dependent methyltransferase
H175_RS21695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H175_RS21700	COG0358	DNA primase activity
H175_RS21710	COG0517	IMP dehydrogenase activity
H175_RS21725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H175_RS21730	COG0295	cytidine deaminase activity
H175_RS21735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H175_RS21745	COG1480	7TM receptor with intracellular HD hydrolase
H175_RS21750	COG1702	phosphate starvation-inducible protein PhoH
H175_RS21770	COG1610	YqeY-like protein
H175_RS21775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H175_RS21780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H175_RS21785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H175_RS21815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H175_RS21820	COG1733	regulation of RNA biosynthetic process
H175_RS21845	COG1466	dna polymerase III delta subunit
H175_RS21855	COG0658	competence protein
H175_RS21855	COG2333	competence protein COMEC
H175_RS21860	COG2131	deaminase
H175_RS21865	COG1596	polysaccharide export
H175_RS21865	COG1555	photosystem II stabilization
H175_RS21870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H175_RS21875	COG2226	methyltransferase
H175_RS21880	COG0799	negative regulation of ribosome biogenesis
H175_RS21885	COG1713	HD superfamily hydrolase involved in NAD metabolism
H175_RS21895	COG1534	Rna-binding protein
H175_RS21905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H175_RS21910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H175_RS21935	COG1595	DNA-templated transcription, initiation
H175_RS21945	COG0778	Nitroreductase
H175_RS21950	COG2357	RelA SpoT domain protein
H175_RS21960	COG1785	Belongs to the alkaline phosphatase family
H175_RS21970	COG2267	carboxylic ester hydrolase activity
H175_RS22005	COG1404	Belongs to the peptidase S8 family
H175_RS22010	COG3186	Phenylalanine-4-hydroxylase
H175_RS22020	COG2514	catechol 2,3-dioxygenase activity
H175_RS22025	COG2259	Doxx family
H175_RS22065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS22075	COG1012	belongs to the aldehyde dehydrogenase family
H175_RS22075	COG1454	alcohol dehydrogenase
H175_RS22080	COG0626	cystathionine gamma-synthase activity
H175_RS22085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H175_RS22110	COG0768	penicillin binding
H175_RS22125	COG0826	peptidase U32
H175_RS22130	COG0826	peptidase U32
H175_RS22135	COG4122	O-methyltransferase activity
H175_RS22140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H175_RS22155	COG4472	Bacterial protein of unknown function (DUF965)
H175_RS22170	COG0628	permease
H175_RS22190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H175_RS22205	COG1104	cysteine desulfurase activity
H175_RS22210	COG1959	2 iron, 2 sulfur cluster binding
H175_RS22215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H175_RS22225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H175_RS22250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H175_RS22260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H175_RS22260	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H175_RS22265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H175_RS22270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H175_RS22270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H175_RS22280	COG2244	polysaccharide biosynthetic process
H175_RS22285	COG2323	membrane
H175_RS22295	COG1862	Preprotein translocase
H175_RS22325	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H175_RS22355	COG0157	Belongs to the NadC ModD family
H175_RS22360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H175_RS22365	COG1104	cysteine desulfurase activity
H175_RS22370	COG1827	regulation of RNA biosynthetic process
H175_RS22375	COG2258	MOSC domain
H175_RS22380	COG0077	Prephenate dehydratase
H175_RS22385	COG0577	efflux transmembrane transporter activity
H175_RS22390	COG0577	efflux transmembrane transporter activity
H175_RS22395	COG1136	(ABC) transporter
H175_RS22400	COG5002	protein histidine kinase activity
H175_RS22405	COG0745	RESPONSE REGULATOR receiver
H175_RS22415	COG3290	protein histidine kinase activity
H175_RS22425	COG2868	ribosomal protein
H175_RS22435	COG1530	ribonuclease E activity
H175_RS22440	COG1994	Peptidase M50
H175_RS22445	COG0739	heme binding
H175_RS22450	COG2894	cell division
H175_RS22470	COG1077	Cell shape determining protein MreB Mrl
H175_RS22490	COG0285	dihydrofolate synthase activity
H175_RS22505	COG1388	LysM domain
H175_RS22515	COG0113	porphobilinogen synthase activity
H175_RS22520	COG1587	Uroporphyrinogen-III synthase
H175_RS22530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H175_RS22540	COG1846	Transcriptional regulator
H175_RS22545	COG1764	response to oxidative stress
H175_RS22560	COG0470	DNA polymerase III
H175_RS22560	COG1067	ATP-dependent peptidase activity
H175_RS22655	COG3611	Membrane attachment protein
H175_RS22695	COG0622	Phosphoesterase
H175_RS22710	COG5401	PFAM Sporulation and spore germination
H175_RS22730	COG1309	transcriptional regulator
H175_RS22740	COG2197	response regulator
H175_RS22745	COG2233	PERMEase
H175_RS22750	COG0402	S-adenosylhomocysteine deaminase activity
H175_RS22755	COG1983	PspC domain protein
H175_RS22760	COG1396	sequence-specific DNA binding
H175_RS22765	COG0697	spore germination
H175_RS22775	COG1959	2 iron, 2 sulfur cluster binding
H175_RS22780	COG1668	transmembrane transport
H175_RS22785	COG4152	abc transporter atp-binding protein
H175_RS22790	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H175_RS22795	COG1360	Flagellar Motor Protein
H175_RS22800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H175_RS22805	COG1876	peptidase activity
H175_RS22810	COG0824	Thioesterase
H175_RS22815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H175_RS22820	COG1053	succinate dehydrogenase
H175_RS22825	COG2009	succinate dehydrogenase
H175_RS22830	COG1719	4-vinyl reductase, 4VR
H175_RS22840	COG3118	belongs to the thioredoxin family
H175_RS22845	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H175_RS22850	COG2086	electron transfer activity
H175_RS22855	COG1024	Enoyl-CoA hydratase
H175_RS22860	COG1309	transcriptional regulator
H175_RS22865	COG0318	PFAM AMP-dependent synthetase and ligase
H175_RS22890	COG2318	DinB family
H175_RS22915	COG1131	(ABC) transporter
H175_RS22920	COG2205	protein histidine kinase activity
H175_RS22925	COG0745	RESPONSE REGULATOR receiver
H175_RS22935	COG4895	conserved protein (DUF2196)
H175_RS22940	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H175_RS22950	COG4509	Sortase family
H175_RS22955	COG1120	ATPase activity
H175_RS22970	COG5386	Cell surface protein
H175_RS22980	COG5386	Cell surface protein
H175_RS22985	COG1114	Component of the transport system for branched-chain amino acids
H175_RS22990	COG1187	pseudouridine synthase activity
H175_RS23000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H175_RS23000	COG1796	DNA polymerase
H175_RS23005	COG1286	toxin biosynthetic process
H175_RS23040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H175_RS23045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H175_RS23055	COG1418	mRNA catabolic process
H175_RS23075	COG2814	Major facilitator Superfamily
H175_RS23080	COG1566	PFAM secretion protein HlyD family protein
H175_RS23085	COG1309	transcriptional regulator
H175_RS23090	COG1363	Peptidase, m42
H175_RS23115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H175_RS23130	COG1484	DNA-dependent DNA replication
H175_RS23135	COG3611	Membrane attachment protein
H175_RS23145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H175_RS23150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H175_RS23155	COG0237	dephospho-CoA kinase activity
H175_RS23160	COG1971	Probably functions as a manganese efflux pump
H175_RS23170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H175_RS23170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H175_RS23175	COG5002	protein histidine kinase activity
H175_RS23180	COG0745	RESPONSE REGULATOR receiver
H175_RS23200	COG0538	isocitrate dehydrogenase activity
H175_RS23205	COG0372	Belongs to the citrate synthase family
H175_RS23215	COG0628	permease
H175_RS23220	COG3030	protein affecting phage T7 exclusion by the F plasmid
H175_RS23245	COG1725	Transcriptional regulator
H175_RS23250	COG0281	malic enzyme
H175_RS23255	COG0587	DNA-directed DNA polymerase activity
H175_RS23270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H175_RS23285	COG4109	DRTGG domain
H175_RS23300	COG0006	proline dipeptidase activity
H175_RS23335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS23340	COG0662	Cupin 2, conserved barrel domain protein
H175_RS23355	COG1028	Short-chain dehydrogenase reductase Sdr
H175_RS23360	COG0589	response to stress
H175_RS23400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS23425	COG0827	DNA restriction-modification system
H175_RS23430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H175_RS23435	COG3874	Sporulation protein YtfJ
H175_RS23450	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H175_RS23460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H175_RS23475	COG1104	cysteine desulfurase activity
H175_RS23485	COG0583	DNA-binding transcription factor activity
H175_RS23490	COG0697	spore germination
H175_RS23495	COG1309	transcriptional regulator
H175_RS23500	COG1956	GAF domain-containing protein
H175_RS23505	COG0626	cystathionine gamma-synthase activity
H175_RS23535	COG1595	DNA-templated transcription, initiation
H175_RS23545	COG0110	maltose O-acetyltransferase activity
H175_RS23550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H175_RS23555	COG0454	-acetyltransferase
H175_RS23560	COG0517	IMP dehydrogenase activity
H175_RS23565	COG0123	including yeast histone deacetylase and acetoin utilization protein
H175_RS23570	COG2267	carboxylic ester hydrolase activity
H175_RS23580	COG0745	RESPONSE REGULATOR receiver
H175_RS23585	COG5002	protein histidine kinase activity
H175_RS23590	COG0666	response to abiotic stimulus
H175_RS23620	COG1609	Transcriptional regulator
H175_RS23625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H175_RS23625	COG1605	Chorismate mutase
H175_RS23630	COG1605	Chorismate mutase
H175_RS23630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H175_RS23635	COG1605	Chorismate mutase
H175_RS23635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H175_RS23640	COG4851	CamS sex pheromone cAM373 precursor
H175_RS23645	COG3118	belongs to the thioredoxin family
H175_RS23655	COG2309	aminopeptidase activity
H175_RS23670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS23675	COG0697	spore germination
H175_RS23680	COG0789	Transcriptional regulator
H175_RS23695	COG1674	ftsk spoiiie
H175_RS23710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H175_RS23720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H175_RS23725	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H175_RS23730	COG1363	Peptidase, m42
H175_RS23740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS23755	COG0510	thiamine kinase activity
H175_RS23760	COG1523	belongs to the glycosyl hydrolase 13 family
H175_RS23770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H175_RS23775	COG1349	DNA-binding transcription factor activity
H175_RS23780	COG1187	pseudouridine synthase activity
H175_RS23785	COG2244	polysaccharide biosynthetic process
H175_RS23790	COG2081	HI0933 family
H175_RS23795	COG2814	Major facilitator Superfamily
H175_RS23805	COG3832	glyoxalase III activity
H175_RS23825	COG1329	Transcriptional regulator
H175_RS23850	COG0314	molybdopterin synthase activity
H175_RS23855	COG1763	Mo-molybdopterin cofactor biosynthetic process
H175_RS23860	COG0303	'Molybdopterin
H175_RS23870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H175_RS23875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H175_RS23895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H175_RS23905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H175_RS23945	COG2814	Major facilitator Superfamily
H175_RS23950	COG0475	glutathione-regulated potassium exporter activity
H175_RS23955	COG0490	domain, Protein
H175_RS23960	COG0582	viral genome integration into host DNA
H175_RS23970	COG1136	(ABC) transporter
H175_RS24000	COG1242	4 iron, 4 sulfur cluster binding
H175_RS24005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H175_RS24010	COG1131	(ABC) transporter
H175_RS24020	COG1794	racemase activity, acting on amino acids and derivatives
H175_RS24040	COG2267	carboxylic ester hydrolase activity
H175_RS24045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H175_RS24050	COG0671	phosphoesterase, PA-phosphatase related
H175_RS24055	COG0438	transferase activity, transferring glycosyl groups
H175_RS24135	COG5002	protein histidine kinase activity
H175_RS24140	COG3852	Histidine kinase
H175_RS24145	COG0753	catalase activity
H175_RS24150	COG2267	carboxylic ester hydrolase activity
H175_RS24155	COG1368	sulfuric ester hydrolase activity
H175_RS24175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H175_RS24180	COG1116	anion transmembrane transporter activity
H175_RS24185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H175_RS24210	COG0494	nUDIX hydrolase
H175_RS24240	COG2076	Multidrug Resistance protein
H175_RS24245	COG2076	Multidrug Resistance protein
H175_RS24250	COG0789	Transcriptional regulator
H175_RS24255	COG1854	S-ribosylhomocysteine lyase activity
H175_RS24265	COG0288	reversible hydration of carbon dioxide
H175_RS24270	COG1271	oxidase subunit
H175_RS24275	COG1294	oxidase, subunit
H175_RS24290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS24310	COG1842	Phage shock protein A
H175_RS24335	COG3859	Proton-coupled thiamine transporter YuaJ
H175_RS24340	COG5002	protein histidine kinase activity
H175_RS24345	COG0745	RESPONSE REGULATOR receiver
H175_RS24370	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H175_RS24375	COG1597	lipid kinase activity
H175_RS24385	COG0577	efflux transmembrane transporter activity
H175_RS24390	COG1136	(ABC) transporter
H175_RS24405	COG0586	Pfam SNARE associated Golgi protein
H175_RS24415	COG0577	efflux transmembrane transporter activity
H175_RS24420	COG1136	(ABC) transporter
H175_RS24425	COG2207	Transcriptional regulator
H175_RS24425	COG3708	Transcriptional regulator
H175_RS24435	COG5658	integral membrane protein
H175_RS24440	COG0640	Transcriptional regulator
H175_RS24445	COG0745	RESPONSE REGULATOR receiver
H175_RS24450	COG2205	protein histidine kinase activity
H175_RS24455	COG0577	efflux transmembrane transporter activity
H175_RS24460	COG0577	efflux transmembrane transporter activity
H175_RS24465	COG1136	(ABC) transporter
H175_RS24470	COG0577	efflux transmembrane transporter activity
H175_RS24495	COG2188	Transcriptional regulator
H175_RS24515	COG3964	amidohydrolase
H175_RS24535	COG4948	Mandelate Racemase Muconate Lactonizing
H175_RS24545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H175_RS24550	COG0596	Alpha beta hydrolase
H175_RS24560	COG1169	isochorismate synthase
H175_RS24565	COG1575	Belongs to the MenA family. Type 1 subfamily
H175_RS24570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H175_RS24575	COG1278	Cold shock
H175_RS24600	COG0058	SHG alpha-glucan phosphorylase activity
H175_RS24610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H175_RS24630	COG1404	Belongs to the peptidase S8 family
H175_RS24725	COG1285	pathogenesis
H175_RS24730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H175_RS24745	COG2155	Conserved Protein
H175_RS24750	COG1098	S1 RNA binding domain
H175_RS24755	COG0436	Aminotransferase
H175_RS24760	COG1522	sequence-specific DNA binding
H175_RS24765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H175_RS24770	COG2267	carboxylic ester hydrolase activity
H175_RS24780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H175_RS24800	COG5018	Exonuclease
H175_RS24805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H175_RS24825	COG2050	protein possibly involved in aromatic compounds catabolism
H175_RS24835	COG1268	BioY protein
H175_RS24840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H175_RS24845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H175_RS24865	COG2076	Multidrug Resistance protein
H175_RS24870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H175_RS24880	COG3584	3D domain protein
H175_RS24895	COG1252	NADH dehydrogenase
H175_RS24910	COG3708	Transcriptional regulator
H175_RS24925	COG1683	Conserved Protein
H175_RS24975	COG1388	LysM domain
H175_RS24975	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS24975	COG5632	N-Acetylmuramoyl-L-alanine amidase
H175_RS24980	COG4824	toxin secretion phage lysis holin
H175_RS25115	COG1191	sigma factor activity
H175_RS25140	COG3645	SOS response
H175_RS25140	COG3646	Phage regulatory protein
H175_RS25160	COG1396	sequence-specific DNA binding
H175_RS25195	COG4122	O-methyltransferase activity
H175_RS25210	COG0316	Belongs to the HesB IscA family
H175_RS25225	COG1252	NADH dehydrogenase
H175_RS25235	COG2274	protein secretion by the type I secretion system
H175_RS25240	COG0390	transport system, permease component
H175_RS25245	COG2824	Alkylphosphonate utilization operon protein PhnA
H175_RS25270	COG4837	Protein of unknown function (DUF1462)
H175_RS25275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H175_RS25285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H175_RS25290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H175_RS25310	COG1358	cellular component organization or biogenesis
H175_RS25320	COG2249	NAD(P)H dehydrogenase (quinone) activity
H175_RS25325	COG0647	UMP catabolic process
H175_RS25335	COG2445	Protein of unknown function DUF86
H175_RS25340	COG1494	fructose-1,6-bisphosphatase
H175_RS25360	COG4470	Protein conserved in bacteria
H175_RS25370	COG0789	Transcriptional regulator
H175_RS25375	COG4377	Putative membrane peptidase family (DUF2324)
H175_RS25400	COG0739	heme binding
H175_RS25410	COG3377	Domain of unknown function (DUF1805)
H175_RS25415	COG0737	Belongs to the 5'-nucleotidase family
H175_RS25420	COG0719	Fe-S assembly protein
H175_RS25425	COG0822	iron-sulfur transferase activity
H175_RS25430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H175_RS25435	COG0719	Fe-S assembly protein
H175_RS25440	COG0396	ATPase activity
H175_RS25445	COG1464	Belongs to the NlpA lipoprotein family
H175_RS25450	COG1464	Belongs to the NlpA lipoprotein family
H175_RS25455	COG2011	ABC-type metal ion transport system permease component
H175_RS25470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H175_RS25475	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H175_RS25485	COG1393	Belongs to the ArsC family
H175_RS25520	COG0039	L-malate dehydrogenase activity
H175_RS25540	COG1309	transcriptional regulator
H175_RS25545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H175_RS25550	COG1960	acyl-CoA dehydrogenase activity
H175_RS25555	COG0183	Belongs to the thiolase family
H175_RS25560	COG1024	Enoyl-CoA hydratase
H175_RS25560	COG1250	3-hydroxyacyl-CoA dehydrogenase
H175_RS25570	COG1686	Belongs to the peptidase S11 family
H175_RS25585	COG0011	TIGRFAM Protein of
H175_RS25590	COG0840	transmembrane signaling receptor activity
H175_RS25605	COG2814	Major facilitator Superfamily
H175_RS25610	COG0531	amino acid
H175_RS25635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H175_RS25665	COG0586	Pfam SNARE associated Golgi protein
H175_RS25675	COG1376	ErfK ybiS ycfS ynhG family protein
H175_RS25680	COG0745	RESPONSE REGULATOR receiver
H175_RS25685	COG5002	protein histidine kinase activity
H175_RS25715	COG0840	transmembrane signaling receptor activity
H175_RS25720	COG2151	metal-sulfur cluster biosynthetic enzyme
H175_RS25725	COG3227	Zinc metalloprotease (Elastase)
H175_RS25745	COG0586	Pfam SNARE associated Golgi protein
H175_RS25750	COG0475	glutathione-regulated potassium exporter activity
H175_RS25755	COG0490	domain, Protein
H175_RS25760	COG1115	amino acid carrier protein
H175_RS25765	COG0783	Belongs to the Dps family
H175_RS25775	COG2318	DinB family
H175_RS25785	COG1611	Belongs to the LOG family
H175_RS25795	COG1528	Iron-storage protein
H175_RS25805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS25810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS25815	COG1115	amino acid carrier protein
H175_RS25820	COG1115	amino acid carrier protein
H175_RS25825	COG2910	NAD(P)H-binding
H175_RS25840	COG0656	L-ascorbic acid biosynthetic process
H175_RS25845	COG2814	Major facilitator Superfamily
H175_RS25850	COG1733	regulation of RNA biosynthetic process
H175_RS25860	COG1252	NADH dehydrogenase
H175_RS25865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H175_RS25915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H175_RS25930	COG1335	isochorismatase
H175_RS25935	COG1522	sequence-specific DNA binding
H175_RS26000	COG0557	exoribonuclease II activity
H175_RS26005	COG1647	Serine aminopeptidase, S33
H175_RS26010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H175_RS26015	COG1346	cytolysis
H175_RS26050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H175_RS26065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H175_RS26075	COG4585	Histidine kinase
H175_RS26105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H175_RS26120	COG2323	membrane
H175_RS26130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H175_RS26140	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H175_RS26150	COG1051	belongs to the nudix hydrolase family
H175_RS26160	COG0492	ferredoxin-NADP+ reductase activity
H175_RS26165	COG0457	Tetratricopeptide repeat
H175_RS26170	COG0110	maltose O-acetyltransferase activity
H175_RS26190	COG1950	PFAM Membrane protein of
H175_RS26200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H175_RS26220	COG0789	Transcriptional regulator
H175_RS26240	COG0583	DNA-binding transcription factor activity
H175_RS26250	COG0655	NAD(P)H dehydrogenase (quinone) activity
H175_RS26255	COG0488	(ABC) transporter
H175_RS26265	COG1132	(ABC) transporter
H175_RS26270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H175_RS26275	COG3409	Peptidoglycan-binding domain 1 protein
H175_RS26275	COG0793	Belongs to the peptidase S41A family
H175_RS26280	COG2177	Part of the ABC transporter FtsEX involved in
H175_RS26285	COG2884	Cell division ATP-binding protein ftsE
H175_RS26295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H175_RS26305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H175_RS26310	COG1278	Cold shock
H175_RS26315	COG1040	competence protein
H175_RS26320	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H175_RS26325	COG0791	NLP P60 protein
H175_RS26325	COG1388	LysM domain
H175_RS26330	COG1733	regulation of RNA biosynthetic process
H175_RS26335	COG1307	EDD domain protein, DegV family
H175_RS26340	COG1739	Uncharacterized protein family UPF0029
H175_RS26345	COG1316	TRANSCRIPTIONal
H175_RS26350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H175_RS26355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H175_RS26360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H175_RS26370	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H175_RS26370	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H175_RS26390	COG1486	melibiose metabolic process
H175_RS26395	COG1447	Phosphotransferase system cellobiose-specific component IIA
H175_RS26400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H175_RS26420	COG1447	Phosphotransferase system cellobiose-specific component IIA
H175_RS26430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H175_RS26435	COG1301	dicarboxylic acid transport
H175_RS26450	COG1511	domain protein
H175_RS26455	COG0583	DNA-binding transcription factor activity
H175_RS26460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H175_RS26470	COG1271	oxidase subunit
H175_RS26475	COG1294	oxidase, subunit
H175_RS26480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H175_RS26510	COG1620	l-lactate permease
H175_RS26520	COG2389	metal-binding protein
H175_RS26530	COG1368	sulfuric ester hydrolase activity
H175_RS26540	COG0791	NLP P60 protein
H175_RS26540	COG1388	LysM domain
H175_RS26545	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H175_RS26555	COG1215	transferase activity, transferring glycosyl groups
H175_RS26565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H175_RS26570	COG1388	LysM domain
H175_RS26570	COG3584	3D domain protein
H175_RS26595	COG4715	Zinc finger, swim domain protein
H175_RS26600	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H175_RS26610	COG3547	Transposase (IS116 IS110 IS902 family)
H175_RS26645	COG0577	efflux transmembrane transporter activity
H175_RS26650	COG1136	(ABC) transporter
H175_RS26685	COG5002	protein histidine kinase activity
H175_RS26690	COG0745	RESPONSE REGULATOR receiver
H175_RS26695	COG1482	cell wall glycoprotein biosynthetic process
H175_RS26700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H175_RS26700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H175_RS26700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H175_RS26705	COG3711	transcriptional antiterminator
H175_RS26705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H175_RS26710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H175_RS26725	COG1482	cell wall glycoprotein biosynthetic process
H175_RS26730	COG0662	Cupin 2, conserved barrel domain protein
H175_RS26730	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H175_RS26745	COG0438	transferase activity, transferring glycosyl groups
H175_RS26755	COG0297	glycogen (starch) synthase activity
H175_RS26755	COG0438	transferase activity, transferring glycosyl groups
H175_RS26760	COG0110	maltose O-acetyltransferase activity
H175_RS26780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H175_RS26785	COG4464	protein tyrosine phosphatase activity
H175_RS26790	COG0489	protein tyrosine kinase activity
H175_RS26795	COG3944	biosynthesis protein
H175_RS26800	COG0489	protein tyrosine kinase activity
H175_RS26815	COG1609	Transcriptional regulator
H175_RS26825	COG0739	heme binding
H175_RS26840	COG3279	Response regulator of the LytR AlgR family
H175_RS26845	COG2385	sporulation resulting in formation of a cellular spore
H175_RS26860	COG4836	Membrane
H175_RS26865	COG1007	ATP synthesis coupled electron transport
H175_RS26870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H175_RS26875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H175_RS26885	COG0839	Belongs to the complex I subunit 6 family
H175_RS26905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H175_RS26920	COG5001	Diguanylate cyclase
H175_RS26920	COG3300	MHYT domain
H175_RS26970	COG0356	it plays a direct role in the translocation of protons across the membrane
H175_RS27005	COG0698	ribose 5-phosphate isomerase
H175_RS27015	COG2190	(PTS) system
H175_RS27020	COG2259	Doxx family
H175_RS27025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H175_RS27040	COG0009	L-threonylcarbamoyladenylate synthase
H175_RS27075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H175_RS27080	COG1494	fructose-1,6-bisphosphatase
H175_RS27100	COG4821	SIS domain
H175_RS27120	COG1960	acyl-CoA dehydrogenase activity
H175_RS27125	COG1960	acyl-CoA dehydrogenase activity
H175_RS27130	COG1250	3-hydroxyacyl-CoA dehydrogenase
H175_RS27135	COG0183	Belongs to the thiolase family
H175_RS27140	COG2181	nitrate reductase activity
H175_RS27140	COG0247	lactate metabolic process
H175_RS27145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H175_RS27165	COG5001	Diguanylate cyclase
H175_RS27165	COG3300	MHYT domain
H175_RS27180	COG3227	Zinc metalloprotease (Elastase)
H175_RS27185	COG2197	response regulator
H175_RS27190	COG4585	Histidine kinase
H175_RS27195	COG0842	Transport permease protein
H175_RS27200	COG1131	(ABC) transporter
H175_RS27205	COG0024	Methionine aminopeptidase
H175_RS27215	COG2234	aminopeptidase activity
H175_RS27235	COG1595	DNA-templated transcription, initiation
H175_RS27245	COG4506	Protein conserved in bacteria
H175_RS27250	COG1619	proteins homologs of microcin C7 resistance protein MccF
H175_RS27280	COG2814	Major facilitator Superfamily
H175_RS27285	COG0789	Transcriptional regulator
H175_RS27290	COG0584	glycerophosphoryl diester phosphodiesterase
H175_RS27295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H175_RS27305	COG1994	Peptidase M50
H175_RS27315	COG1078	dGTPase activity
H175_RS27320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H175_RS27325	COG1120	ATPase activity
H175_RS27330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS27335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H175_RS27355	COG0280	phosphate acetyltransferase
H175_RS27370	COG3773	Cell wall hydrolase
H175_RS27380	COG2363	Small membrane protein
H175_RS27390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H175_RS27395	COG2233	PERMEase
H175_RS27400	COG0561	phosphatase activity
H175_RS27405	COG2814	Major facilitator Superfamily
H175_RS27415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
H175_RS27420	COG1131	(ABC) transporter
H175_RS27425	COG2755	lipolytic protein G-D-S-L family
H175_RS27430	COG1609	Transcriptional regulator
H175_RS27440	COG0460	homoserine dehydrogenase
H175_RS27450	COG2873	o-acetylhomoserine
H175_RS27460	COG1011	Hydrolase
H175_RS27465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H175_RS27475	COG2197	response regulator
H175_RS27480	COG2203	Gaf domain
H175_RS27480	COG4585	Histidine kinase
H175_RS27485	COG0351	phosphomethylpyrimidine kinase
H175_RS27490	COG3706	GGDEF domain
H175_RS27495	COG2879	small protein
H175_RS27500	COG1966	Carbon starvation protein
H175_RS27505	COG3279	Response regulator of the LytR AlgR family
H175_RS27510	COG0477	Major facilitator Superfamily
H175_RS27520	COG0438	transferase activity, transferring glycosyl groups
H175_RS27535	COG0840	transmembrane signaling receptor activity
H175_RS27545	COG1607	acyl-coa hydrolase
H175_RS27550	COG1216	Glycosyl transferase, family 2
H175_RS27560	COG1216	Glycosyl transferase, family 2
H175_RS27570	COG4485	Bacterial membrane protein, YfhO
H175_RS27575	COG0463	Glycosyl transferase, family 2
H175_RS27585	COG1309	transcriptional regulator
H175_RS27590	COG0488	(ABC) transporter
H175_RS27595	COG1309	transcriptional regulator
H175_RS27600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H175_RS27605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H175_RS27605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H175_RS27610	COG0628	permease
H175_RS27630	COG3275	phosphorelay sensor kinase activity
H175_RS27635	COG2814	Major facilitator Superfamily
H175_RS27640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H175_RS27645	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
H175_RS27670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H175_RS27675	COG1272	protein, Hemolysin III
H175_RS27695	COG1164	Oligoendopeptidase f
H175_RS27705	COG5002	protein histidine kinase activity
H175_RS27720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H175_RS27725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H175_RS27730	COG4853	Protein conserved in bacteria
H175_RS27740	COG5002	protein histidine kinase activity
H175_RS27745	COG0745	RESPONSE REGULATOR receiver
H175_RS27775	COG0305	Participates in initiation and elongation during chromosome replication
H175_RS27785	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H175_RS27790	COG4241	membrane
H175_RS27800	COG0629	single-stranded DNA binding
H175_RS27810	COG0012	GTP binding
H175_RS27815	COG4481	Protein conserved in bacteria
H175_RS27820	COG0668	transmembrane transport
H175_RS27830	COG1475	DNA binding
H175_RS27835	COG1192	Involved in chromosome partitioning
H175_RS27860	COG1847	R3H domain protein
H175_RS27865	COG0706	membrane insertase activity
H175_RS27875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H175_RS28125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS28280	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS28715	COG2244	polysaccharide biosynthetic process
H175_RS28780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS29180	COG0187	DNA topoisomerase II activity
H175_RS29185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS29280	COG0590	tRNA wobble adenosine to inosine editing
H175_RS29550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H175_RS29565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H175_RS29690	COG0516	GMP reductase activity
H175_RS29690	COG0517	IMP dehydrogenase activity
H175_RS29990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H175_RS30005	COG0512	Glutamine amidotransferase of anthranilate synthase
H175_RS30255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS31075	COG0444	Belongs to the ABC transporter superfamily
H175_RS31140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS31295	COG1774	PSP1 C-terminal conserved region
H175_RS31380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H175_RS31445	COG2208	phosphoserine phosphatase activity
H175_RS32005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS32010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS32165	COG0488	(ABC) transporter
H175_RS32195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H175_RS32210	COG3185	4-Hydroxyphenylpyruvate dioxygenase
H175_RS32220	COG0531	amino acid
H175_RS32435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H175_RS32475	COG0517	IMP dehydrogenase activity
H175_RS32475	COG0516	GMP reductase activity
H175_RS32660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H175_RS32665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H175_RS32720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H175_RS32765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H175_RS32880	COG0215	cysteine-tRNA ligase activity
H175_RS32945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H175_RS33175	COG0604	alcohol dehydrogenase
H175_RS33215	COG0444	Belongs to the ABC transporter superfamily
H175_RS33505	COG5002	protein histidine kinase activity
H175_RS33675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H175_RS33780	COG2376	Dihydroxyacetone kinase