locus-tag	class	description
EXW25_RS00010	COG0592	DNA-directed DNA polymerase activity
EXW25_RS00015	COG2501	S4 domain
EXW25_RS00025	COG0187	DNA topoisomerase II activity
EXW25_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW25_RS00065	COG0516	GMP reductase activity
EXW25_RS00065	COG0517	IMP dehydrogenase activity
EXW25_RS00070	COG1686	Belongs to the peptidase S11 family
EXW25_RS00100	COG1428	Deoxynucleoside kinase
EXW25_RS00105	COG1428	Deoxynucleoside kinase
EXW25_RS00110	COG1335	isochorismatase
EXW25_RS00115	COG0590	tRNA wobble adenosine to inosine editing
EXW25_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW25_RS00180	COG1982	Orn Lys Arg decarboxylase major
EXW25_RS00190	COG0470	DNA polymerase III
EXW25_RS00195	COG1774	PSP1 C-terminal conserved region
EXW25_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW25_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW25_RS00220	COG2002	toxin-antitoxin pair type II binding
EXW25_RS00230	COG0084	hydrolase, TatD family'
EXW25_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW25_RS00250	COG4466	Protein conserved in bacteria
EXW25_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW25_RS00270	COG0251	oxidation-reduction process
EXW25_RS00275	COG2088	sporulation resulting in formation of a cellular spore
EXW25_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW25_RS00305	COG2002	toxin-antitoxin pair type II binding
EXW25_RS00310	COG2244	polysaccharide biosynthetic process
EXW25_RS00315	COG3956	TIGRFAM MazG family protein
EXW25_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW25_RS00340	COG1098	S1 RNA binding domain
EXW25_RS00355	COG2208	phosphoserine phosphatase activity
EXW25_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW25_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW25_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW25_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW25_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW25_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW25_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW25_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW25_RS00420	COG1396	sequence-specific DNA binding
EXW25_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW25_RS00515	COG3880	PFAM UvrB UvrC protein
EXW25_RS00525	COG0542	response to heat
EXW25_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW25_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW25_RS00560	COG1045	serine acetyltransferase
EXW25_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW25_RS00580	COG3688	RNA-binding protein containing a PIN domain
EXW25_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW25_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW25_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW25_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW25_RS00610	COG0081	regulation of translation
EXW25_RS00620	COG0222	ribosome binding
EXW25_RS00625	COG2813	Specifically methylates the guanine in position
EXW25_RS00640	COG1358	cellular component organization or biogenesis
EXW25_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW25_RS00665	COG0051	transcription antitermination factor activity, RNA binding
EXW25_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW25_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW25_RS00760	COG1841	ribosomal large subunit assembly
EXW25_RS00770	COG0201	protein transport
EXW25_RS00780	COG0024	Methionine aminopeptidase
EXW25_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW25_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW25_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS00855	COG0489	protein tyrosine kinase activity
EXW25_RS00865	COG2194	sulfuric ester hydrolase activity
EXW25_RS00870	COG0726	polysaccharide deacetylase
EXW25_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW25_RS00955	COG4856	YbbR-like protein
EXW25_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS00995	COG2011	ABC-type metal ion transport system permease component
EXW25_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW25_RS01005	COG1464	Belongs to the NlpA lipoprotein family
EXW25_RS01020	COG0277	FAD linked oxidase domain protein
EXW25_RS01025	COG2271	Major facilitator Superfamily
EXW25_RS01035	COG2814	Major facilitator Superfamily
EXW25_RS01050	COG0601	transmembrane transport
EXW25_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW25_RS01060	COG0444	Belongs to the ABC transporter superfamily
EXW25_RS01065	COG4608	Belongs to the ABC transporter superfamily
EXW25_RS01070	COG4166	transmembrane transport
EXW25_RS01080	COG2207	Transcriptional regulator
EXW25_RS01090	COG4166	transmembrane transport
EXW25_RS01095	COG4166	transmembrane transport
EXW25_RS01100	COG0656	L-ascorbic acid biosynthetic process
EXW25_RS01120	COG4149	molybdate abc transporter
EXW25_RS01125	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW25_RS01130	COG1910	domain protein
EXW25_RS01145	COG0697	spore germination
EXW25_RS01160	COG0204	Acyl-transferase
EXW25_RS01170	COG1609	Transcriptional regulator
EXW25_RS01180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS01195	COG5298	Protein conserved in bacteria
EXW25_RS01215	COG0488	(ABC) transporter
EXW25_RS01225	COG0747	negative chemotaxis
EXW25_RS01230	COG0601	transmembrane transport
EXW25_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW25_RS01240	COG0444	Belongs to the ABC transporter superfamily
EXW25_RS01245	COG4608	Belongs to the ABC transporter superfamily
EXW25_RS01250	COG0561	phosphatase activity
EXW25_RS01280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW25_RS01285	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW25_RS01295	COG0531	amino acid
EXW25_RS01300	COG2814	Major facilitator Superfamily
EXW25_RS01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW25_RS01320	COG4294	response to UV
EXW25_RS01325	COG0705	Rhomboid family
EXW25_RS01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW25_RS01340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW25_RS01345	COG0864	Transcriptional regulator
EXW25_RS01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW25_RS01355	COG2183	response to ionizing radiation
EXW25_RS01455	COG0802	atpase or kinase
EXW25_RS01460	COG1214	PFAM Peptidase M22, glycoprotease
EXW25_RS01465	COG0456	acetyltransferase
EXW25_RS01475	COG0488	(ABC) transporter
EXW25_RS01490	COG1266	CAAX protease self-immunity
EXW25_RS01500	COG0459	protein refolding
EXW25_RS01515	COG2252	PERMEase
EXW25_RS01525	COG5002	protein histidine kinase activity
EXW25_RS01545	COG0697	spore germination
EXW25_RS01590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW25_RS01600	COG1215	transferase activity, transferring glycosyl groups
EXW25_RS01625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW25_RS01665	COG2205	protein histidine kinase activity
EXW25_RS01670	COG0745	RESPONSE REGULATOR receiver
EXW25_RS01690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW25_RS01695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW25_RS01700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW25_RS01710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW25_RS01725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW25_RS01735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW25_RS01740	COG0138	bifunctional purine biosynthesis protein purh
EXW25_RS01745	COG0151	Belongs to the GarS family
EXW25_RS01770	COG0210	DNA helicase
EXW25_RS01780	COG4851	CamS sex pheromone cAM373 precursor
EXW25_RS01795	COG1335	isochorismatase
EXW25_RS01805	COG2011	ABC-type metal ion transport system permease component
EXW25_RS01810	COG1464	Belongs to the NlpA lipoprotein family
EXW25_RS01825	COG0003	Pfam Anion-transporting ATPase
EXW25_RS01830	COG1846	Transcriptional regulator
EXW25_RS01835	COG4682	membrane
EXW25_RS01855	COG1597	lipid kinase activity
EXW25_RS01860	COG0546	phosphoglycolate phosphatase activity
EXW25_RS01865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS01880	COG2076	Multidrug Resistance protein
EXW25_RS01890	COG2309	aminopeptidase activity
EXW25_RS01905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS01915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW25_RS01920	COG5002	protein histidine kinase activity
EXW25_RS01930	COG4807	Protein conserved in bacteria
EXW25_RS01955	COG1757	Na H antiporter
EXW25_RS01960	COG1473	amidohydrolase
EXW25_RS01975	COG0450	alkyl hydroperoxide reductase
EXW25_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS02000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS02005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS02010	COG0492	ferredoxin-NADP+ reductase activity
EXW25_RS02020	COG0166	Belongs to the GPI family
EXW25_RS02045	COG5002	protein histidine kinase activity
EXW25_RS02065	COG3541	Predicted nucleotidyltransferase
EXW25_RS02070	COG2814	Major facilitator Superfamily
EXW25_RS02075	COG0723	plastoquinol--plastocyanin reductase activity
EXW25_RS02075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW25_RS02085	COG0765	amino acid transport
EXW25_RS02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW25_RS02100	COG0840	transmembrane signaling receptor activity
EXW25_RS02125	COG0549	Belongs to the carbamate kinase family
EXW25_RS02140	COG0277	FAD linked oxidase domain protein
EXW25_RS02145	COG0366	Alpha amylase catalytic
EXW25_RS02150	COG2190	(PTS) system
EXW25_RS02150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS02150	COG1263	PTS System
EXW25_RS02180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW25_RS02185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW25_RS02205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW25_RS02215	COG1116	anion transmembrane transporter activity
EXW25_RS02265	COG2270	Major facilitator Superfamily
EXW25_RS02290	COG4193	domain, Protein
EXW25_RS02290	COG4193	domain, Protein
EXW25_RS02300	COG2310	stress, protein
EXW25_RS02305	COG2310	stress, protein
EXW25_RS02310	COG2310	stress, protein
EXW25_RS02315	COG0861	Integral membrane protein TerC family
EXW25_RS02325	COG3853	Toxic anion resistance protein (TelA)
EXW25_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW25_RS02350	COG1295	ribonuclease BN
EXW25_RS02355	COG2217	Heavy metal translocating P-type atpase
EXW25_RS02360	COG0697	spore germination
EXW25_RS02380	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS02395	COG3871	stress protein (general stress protein 26)
EXW25_RS02400	COG0387	Pfam Sodium calcium exchanger
EXW25_RS02410	COG0535	radical SAM domain protein
EXW25_RS02430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW25_RS02435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXW25_RS02450	COG3829	transcription factor binding
EXW25_RS02460	COG0833	amino acid
EXW25_RS02465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW25_RS02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS02490	COG1263	PTS System
EXW25_RS02495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW25_RS02515	COG0463	Glycosyl transferase, family 2
EXW25_RS02525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW25_RS02525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW25_RS02530	COG0463	Glycosyl transferase, family 2
EXW25_RS02535	COG1882	Formate acetyltransferase
EXW25_RS02540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW25_RS02560	COG1228	amidohydrolase
EXW25_RS02565	COG1090	epimerase
EXW25_RS02595	COG1988	membrane-bound metal-dependent
EXW25_RS02600	COG1194	a g-specific adenine glycosylase
EXW25_RS02620	COG3557	Belongs to the UPF0374 family
EXW25_RS02625	COG1132	(ABC) transporter
EXW25_RS02630	COG4129	membrane
EXW25_RS02635	COG0070	glutamate synthase
EXW25_RS02635	COG0067	glutamate synthase
EXW25_RS02635	COG0069	glutamate synthase activity
EXW25_RS02640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW25_RS02645	COG4555	ABC transporter
EXW25_RS02665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW25_RS02670	COG0735	belongs to the Fur family
EXW25_RS02790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW25_RS02815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW25_RS02820	COG1716	ATPase activity
EXW25_RS02820	COG5001	Diguanylate cyclase
EXW25_RS02825	COG2766	serine protein kinase
EXW25_RS02830	COG2718	Belongs to the UPF0229 family
EXW25_RS02845	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW25_RS02850	COG2268	Band 7 protein
EXW25_RS02860	COG3290	protein histidine kinase activity
EXW25_RS02865	COG4565	transcriptional regulatory protein
EXW25_RS02870	COG2851	Citrate transporter
EXW25_RS02900	COG3842	ATPase activity
EXW25_RS02905	COG1175	transmembrane transport
EXW25_RS02910	COG0395	ABC-type sugar transport system, permease component
EXW25_RS02920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW25_RS02925	COG0745	RESPONSE REGULATOR receiver
EXW25_RS02930	COG5002	protein histidine kinase activity
EXW25_RS02940	COG4990	cell redox homeostasis
EXW25_RS02950	COG3290	protein histidine kinase activity
EXW25_RS02955	COG4565	transcriptional regulatory protein
EXW25_RS02960	COG3493	citrate carrier protein
EXW25_RS02965	COG0281	malic enzyme
EXW25_RS02975	COG0697	spore germination
EXW25_RS02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS02990	COG5002	protein histidine kinase activity
EXW25_RS02995	COG0745	RESPONSE REGULATOR receiver
EXW25_RS03000	COG0454	-acetyltransferase
EXW25_RS03000	COG0456	acetyltransferase
EXW25_RS03005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW25_RS03010	COG3383	formate dehydrogenase (NAD+) activity
EXW25_RS03015	COG2427	Protein of unknown function (DUF1641)
EXW25_RS03030	COG0531	amino acid
EXW25_RS03040	COG0640	Transcriptional regulator
EXW25_RS03045	COG2217	Heavy metal translocating P-type atpase
EXW25_RS03050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW25_RS03065	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS03085	COG2720	vancomycin resistance protein
EXW25_RS03090	COG1316	TRANSCRIPTIONal
EXW25_RS03095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS03100	COG0346	lactoylglutathione lyase activity
EXW25_RS03105	COG1253	flavin adenine dinucleotide binding
EXW25_RS03110	COG1027	Aspartate ammonia-lyase
EXW25_RS03115	COG1620	l-lactate permease
EXW25_RS03130	COG3104	oligopeptide transport
EXW25_RS03135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS03140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS03145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS03155	COG2226	methyltransferase
EXW25_RS03165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW25_RS03175	COG4548	von Willebrand factor, type A
EXW25_RS03180	COG0714	Associated with various cellular activities
EXW25_RS03205	COG0531	amino acid
EXW25_RS03210	COG2188	Transcriptional regulator
EXW25_RS03215	COG1263	PTS System
EXW25_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS03220	COG0366	Alpha amylase catalytic
EXW25_RS03235	COG0697	spore germination
EXW25_RS03240	COG4585	Histidine kinase
EXW25_RS03245	COG2197	response regulator
EXW25_RS03250	COG1404	Belongs to the peptidase S8 family
EXW25_RS03260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW25_RS03265	COG1115	amino acid carrier protein
EXW25_RS03270	COG1126	abc transporter atp-binding protein
EXW25_RS03275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW25_RS03280	COG0765	amino acid transport
EXW25_RS03285	COG0765	amino acid transport
EXW25_RS03290	COG0833	amino acid
EXW25_RS03300	COG1595	DNA-templated transcription, initiation
EXW25_RS03310	COG2378	regulation of single-species biofilm formation
EXW25_RS03315	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW25_RS03320	COG5002	protein histidine kinase activity
EXW25_RS03325	COG0745	RESPONSE REGULATOR receiver
EXW25_RS03335	COG0659	secondary active sulfate transmembrane transporter activity
EXW25_RS03350	COG2271	Major facilitator Superfamily
EXW25_RS03355	COG1846	Transcriptional regulator
EXW25_RS03360	COG0477	Major facilitator Superfamily
EXW25_RS03365	COG1609	Transcriptional regulator
EXW25_RS03370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW25_RS03385	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS03390	COG1879	ABC-type sugar transport system periplasmic component
EXW25_RS03420	COG1063	alcohol dehydrogenase
EXW25_RS03470	COG0840	transmembrane signaling receptor activity
EXW25_RS03475	COG3584	3D domain protein
EXW25_RS03475	COG1388	LysM domain
EXW25_RS03480	COG1476	TRANSCRIPTIONal
EXW25_RS03500	COG3104	oligopeptide transport
EXW25_RS03505	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS03520	COG1113	amino acid transport
EXW25_RS03525	COG2252	PERMEase
EXW25_RS03550	COG0475	glutathione-regulated potassium exporter activity
EXW25_RS03550	COG0569	domain protein
EXW25_RS03560	COG1845	cytochrome c oxidase, subunit III
EXW25_RS03565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW25_RS03570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXW25_RS03575	COG0833	amino acid
EXW25_RS03580	COG4990	cell redox homeostasis
EXW25_RS03595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW25_RS03600	COG0697	spore germination
EXW25_RS03605	COG0531	amino acid
EXW25_RS03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW25_RS03620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW25_RS03625	COG1918	ferrous iron import across plasma membrane
EXW25_RS03625	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW25_RS03630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW25_RS03635	COG0573	inorganic phosphate transmembrane transporter activity
EXW25_RS03640	COG0581	inorganic phosphate transmembrane transporter activity
EXW25_RS03645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW25_RS03765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW25_RS03785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW25_RS03790	COG1116	anion transmembrane transporter activity
EXW25_RS03795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW25_RS03800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW25_RS03805	COG0352	thiamine-phosphate diphosphorylase activity
EXW25_RS03810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW25_RS03815	COG2104	thiamine diphosphate biosynthetic process
EXW25_RS03820	COG2022	thiamine diphosphate biosynthetic process
EXW25_RS03825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW25_RS03830	COG0351	phosphomethylpyrimidine kinase
EXW25_RS03855	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXW25_RS03860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW25_RS03870	COG2205	protein histidine kinase activity
EXW25_RS03875	COG2814	Major facilitator Superfamily
EXW25_RS03880	COG1846	Transcriptional regulator
EXW25_RS03895	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS03900	COG1129	ABC transporter
EXW25_RS03910	COG2252	PERMEase
EXW25_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS03975	COG0778	Nitroreductase
EXW25_RS03980	COG2719	SpoVR family
EXW25_RS03995	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXW25_RS04000	COG1937	Protein conserved in bacteria
EXW25_RS04005	COG0425	Belongs to the sulfur carrier protein TusA family
EXW25_RS04005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS04010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS04010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS04015	COG0425	Belongs to the sulfur carrier protein TusA family
EXW25_RS04020	COG0425	Belongs to the sulfur carrier protein TusA family
EXW25_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS04030	COG2210	Belongs to the sulfur carrier protein TusA family
EXW25_RS04035	COG0730	response to heat
EXW25_RS04045	COG1316	TRANSCRIPTIONal
EXW25_RS04050	COG0604	alcohol dehydrogenase
EXW25_RS04055	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW25_RS04060	COG2814	Major facilitator Superfamily
EXW25_RS04070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW25_RS04070	COG3711	transcriptional antiterminator
EXW25_RS04075	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW25_RS04080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW25_RS04100	COG3584	3D domain protein
EXW25_RS04100	COG1388	LysM domain
EXW25_RS04105	COG0577	efflux transmembrane transporter activity
EXW25_RS04110	COG1136	(ABC) transporter
EXW25_RS04120	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW25_RS04135	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS04140	COG3546	catalase activity
EXW25_RS04175	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS04210	COG0531	amino acid
EXW25_RS04215	COG0475	glutathione-regulated potassium exporter activity
EXW25_RS04225	COG1737	Transcriptional regulator
EXW25_RS04235	COG1263	PTS System
EXW25_RS04235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS04245	COG2259	Doxx family
EXW25_RS04265	COG1522	sequence-specific DNA binding
EXW25_RS04290	COG0596	Alpha beta hydrolase
EXW25_RS04300	COG2076	Multidrug Resistance protein
EXW25_RS04305	COG1309	transcriptional regulator
EXW25_RS04310	COG2814	Major facilitator Superfamily
EXW25_RS04315	COG1733	regulation of RNA biosynthetic process
EXW25_RS04325	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW25_RS04335	COG4533	DNA binding
EXW25_RS04340	COG2211	Major facilitator Superfamily
EXW25_RS04350	COG0693	protein deglycase activity
EXW25_RS04360	COG0531	amino acid
EXW25_RS04365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXW25_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS04375	COG1132	(ABC) transporter
EXW25_RS04380	COG1132	(ABC) transporter
EXW25_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW25_RS04390	COG0765	amino acid transport
EXW25_RS04395	COG1126	abc transporter atp-binding protein
EXW25_RS04410	COG0189	ligase activity
EXW25_RS04430	COG0028	Belongs to the TPP enzyme family
EXW25_RS04435	COG3527	Alpha-acetolactate decarboxylase
EXW25_RS04445	COG0561	phosphatase activity
EXW25_RS04455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW25_RS04460	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS04465	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS04475	COG4978	Transcriptional regulator
EXW25_RS04475	COG0789	Transcriptional regulator
EXW25_RS04485	COG0659	secondary active sulfate transmembrane transporter activity
EXW25_RS04495	COG1024	Enoyl-CoA hydratase
EXW25_RS04515	COG1363	Peptidase, m42
EXW25_RS04545	COG0579	oxidoreductase
EXW25_RS04585	COG0601	transmembrane transport
EXW25_RS04590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW25_RS04595	COG0444	Belongs to the ABC transporter superfamily
EXW25_RS04600	COG4608	Belongs to the ABC transporter superfamily
EXW25_RS04750	COG0477	Major facilitator Superfamily
EXW25_RS04755	COG3290	protein histidine kinase activity
EXW25_RS04760	COG4565	transcriptional regulatory protein
EXW25_RS04765	COG3181	Tripartite tricarboxylate transporter family receptor
EXW25_RS04770	COG0494	nUDIX hydrolase
EXW25_RS04800	COG0326	Molecular chaperone. Has ATPase activity
EXW25_RS04815	COG0789	Transcriptional regulator
EXW25_RS04815	COG4978	Transcriptional regulator
EXW25_RS04830	COG0305	Participates in initiation and elongation during chromosome replication
EXW25_RS04855	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EXW25_RS04860	COG1288	antiporter activity
EXW25_RS04870	COG0477	Major facilitator Superfamily
EXW25_RS04910	COG3409	Peptidoglycan-binding domain 1 protein
EXW25_RS04910	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS04920	COG3711	transcriptional antiterminator
EXW25_RS04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS04925	COG2190	(PTS) system
EXW25_RS04925	COG1263	PTS System
EXW25_RS04930	COG2723	6-phospho-beta-galactosidase activity
EXW25_RS04940	COG1183	phosphatidylcholine synthase activity
EXW25_RS04965	COG2814	Major facilitator Superfamily
EXW25_RS04970	COG0640	Transcriptional regulator
EXW25_RS04985	COG2376	Dihydroxyacetone kinase
EXW25_RS04995	COG2376	Dihydroxyacetone kinase
EXW25_RS05005	COG1959	2 iron, 2 sulfur cluster binding
EXW25_RS05020	COG0745	RESPONSE REGULATOR receiver
EXW25_RS05025	COG5002	protein histidine kinase activity
EXW25_RS05025	COG3850	Histidine kinase
EXW25_RS05065	COG3237	CsbD-like
EXW25_RS05090	COG1191	sigma factor activity
EXW25_RS05100	COG2208	phosphoserine phosphatase activity
EXW25_RS05105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW25_RS05140	COG2807	transmembrane transport
EXW25_RS05145	COG2186	Transcriptional regulator
EXW25_RS05180	COG0420	3'-5' exonuclease activity
EXW25_RS05185	COG4717	serine-type aminopeptidase activity
EXW25_RS05210	COG0346	lactoylglutathione lyase activity
EXW25_RS05215	COG0346	lactoylglutathione lyase activity
EXW25_RS05220	COG0457	Tetratricopeptide repeat
EXW25_RS05230	COG2267	carboxylic ester hydrolase activity
EXW25_RS05240	COG3620	sequence-specific DNA binding
EXW25_RS05245	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW25_RS05250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW25_RS05260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW25_RS05270	COG1595	DNA-templated transcription, initiation
EXW25_RS05280	COG0772	Belongs to the SEDS family
EXW25_RS05290	COG3973	AAA domain
EXW25_RS05295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW25_RS05320	COG0537	adenosine 5'-monophosphoramidase activity
EXW25_RS05325	COG1131	(ABC) transporter
EXW25_RS05330	COG4473	ABC transporter
EXW25_RS05345	COG1309	transcriptional regulator
EXW25_RS05355	COG3402	PFAM membrane-flanked domain
EXW25_RS05360	COG3428	Bacterial PH domain
EXW25_RS05415	COG3402	PFAM membrane-flanked domain
EXW25_RS05420	COG3428	Bacterial PH domain
EXW25_RS05425	COG2329	Antibiotic biosynthesis monooxygenase
EXW25_RS05430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS05445	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW25_RS05470	COG1309	transcriptional regulator
EXW25_RS05475	COG1511	domain protein
EXW25_RS05510	COG1609	Transcriptional regulator
EXW25_RS05520	COG1234	tRNA 3'-trailer cleavage
EXW25_RS05525	COG0095	Lipoate-protein ligase
EXW25_RS05535	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS05560	COG1408	metallophosphoesterase
EXW25_RS05570	COG1078	dGTPase activity
EXW25_RS05580	COG1595	DNA-templated transcription, initiation
EXW25_RS05585	COG2207	Transcriptional regulator
EXW25_RS05585	COG3708	Transcriptional regulator
EXW25_RS05590	COG2205	protein histidine kinase activity
EXW25_RS05595	COG0745	RESPONSE REGULATOR receiver
EXW25_RS05620	COG0501	Belongs to the peptidase M48B family
EXW25_RS05625	COG0840	transmembrane signaling receptor activity
EXW25_RS05630	COG0697	spore germination
EXW25_RS05635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW25_RS05640	COG2224	Isocitrate lyase
EXW25_RS05660	COG1278	Cold shock
EXW25_RS05670	COG4903	ComK protein
EXW25_RS05675	COG0398	Pfam SNARE associated Golgi protein
EXW25_RS05735	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW25_RS05760	COG0367	asparagine synthase
EXW25_RS05770	COG0753	catalase activity
EXW25_RS05775	COG0004	ammonium transporteR
EXW25_RS05795	COG2996	Protein conserved in bacteria
EXW25_RS05830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS05845	COG0561	phosphatase activity
EXW25_RS05865	COG2267	carboxylic ester hydrolase activity
EXW25_RS05880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW25_RS05885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW25_RS05890	COG5504	Zn-dependent protease
EXW25_RS05900	COG0180	Tryptophanyl-tRNA synthetase
EXW25_RS05910	COG4166	transmembrane transport
EXW25_RS05915	COG0601	transmembrane transport
EXW25_RS05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW25_RS05925	COG0444	Belongs to the ABC transporter superfamily
EXW25_RS05930	COG4608	Belongs to the ABC transporter superfamily
EXW25_RS05935	COG0534	Mate efflux family protein
EXW25_RS05940	COG4166	transmembrane transport
EXW25_RS05955	COG0861	Integral membrane protein TerC family
EXW25_RS05965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW25_RS05975	COG1164	Oligoendopeptidase f
EXW25_RS05985	COG2346	COG2346, Truncated hemoglobins
EXW25_RS05990	COG4116	CYTH
EXW25_RS06000	COG2357	RelA SpoT domain protein
EXW25_RS06010	COG0564	pseudouridine synthase activity
EXW25_RS06025	COG0772	Belongs to the SEDS family
EXW25_RS06030	COG1216	Glycosyl transferase, family 2
EXW25_RS06050	COG0463	Glycosyl transferase, family 2
EXW25_RS06050	COG0457	Tetratricopeptide repeat
EXW25_RS06070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW25_RS06085	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW25_RS06130	COG2153	protein acetylation
EXW25_RS06140	COG2382	esterase
EXW25_RS06155	COG5492	domain, Protein
EXW25_RS06160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW25_RS06170	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW25_RS06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW25_RS06175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW25_RS06205	COG1620	l-lactate permease
EXW25_RS06210	COG5634	Uncharacterized conserved protein (DUF2278)
EXW25_RS06290	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW25_RS06300	COG1476	TRANSCRIPTIONal
EXW25_RS06340	COG4152	abc transporter atp-binding protein
EXW25_RS06345	COG1668	transmembrane transport
EXW25_RS06390	COG1686	Belongs to the peptidase S11 family
EXW25_RS06395	COG0681	Belongs to the peptidase S26 family
EXW25_RS06430	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW25_RS06445	COG1177	transmembrane transport
EXW25_RS06450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW25_RS06460	COG2409	Drug exporters of the RND superfamily
EXW25_RS06470	COG0564	pseudouridine synthase activity
EXW25_RS06480	COG2340	Cysteine-rich secretory protein family
EXW25_RS06485	COG0247	lactate metabolic process
EXW25_RS06490	COG0277	FAD linked oxidase domain protein
EXW25_RS06495	COG3835	regulator
EXW25_RS06505	COG0745	RESPONSE REGULATOR receiver
EXW25_RS06510	COG5002	protein histidine kinase activity
EXW25_RS06515	COG2186	Transcriptional regulator
EXW25_RS06535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW25_RS06545	COG2116	formate transmembrane transporter activity
EXW25_RS06550	COG0861	Integral membrane protein TerC family
EXW25_RS06555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW25_RS06565	COG2030	dehydratase
EXW25_RS06585	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS06590	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW25_RS06600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW25_RS06615	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW25_RS06620	COG3842	ATPase activity
EXW25_RS06645	COG1349	DNA-binding transcription factor activity
EXW25_RS06655	COG0235	Class ii aldolase
EXW25_RS06665	COG2861	carbohydrate metabolic process
EXW25_RS06675	COG3852	Histidine kinase
EXW25_RS06680	COG1846	Transcriptional regulator
EXW25_RS06690	COG2318	DinB family
EXW25_RS06695	COG5002	protein histidine kinase activity
EXW25_RS06705	COG0720	synthase
EXW25_RS06720	COG4873	Protein conserved in bacteria
EXW25_RS06735	COG0456	acetyltransferase
EXW25_RS06750	COG1780	Probably involved in ribonucleotide reductase function
EXW25_RS06765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW25_RS06770	COG0531	amino acid
EXW25_RS06775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW25_RS06790	COG2204	response regulator
EXW25_RS06795	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS06805	COG1725	Transcriptional regulator
EXW25_RS06810	COG1131	(ABC) transporter
EXW25_RS06820	COG1131	(ABC) transporter
EXW25_RS06825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW25_RS06840	COG1522	sequence-specific DNA binding
EXW25_RS06850	COG1335	isochorismatase
EXW25_RS06865	COG2070	2-Nitropropane dioxygenase
EXW25_RS06870	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW25_RS06880	COG1696	Membrane protein involved in D-alanine export
EXW25_RS06905	COG0716	FMN binding
EXW25_RS06935	COG0534	Mate efflux family protein
EXW25_RS06960	COG1846	Transcriptional regulator
EXW25_RS06975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW25_RS06980	COG4709	membrane
EXW25_RS06985	COG3874	Sporulation protein YtfJ
EXW25_RS07005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS07010	COG0028	Belongs to the TPP enzyme family
EXW25_RS07015	COG0440	acetolactate synthase activity
EXW25_RS07035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW25_RS07065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW25_RS07075	COG0107	imidazoleglycerol-phosphate synthase activity
EXW25_RS07085	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW25_RS07090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW25_RS07100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW25_RS07105	COG1183	phosphatidylcholine synthase activity
EXW25_RS07110	COG1368	sulfuric ester hydrolase activity
EXW25_RS07120	COG0019	diaminopimelate decarboxylase activity
EXW25_RS07140	COG0529	Catalyzes the synthesis of activated sulfate
EXW25_RS07145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW25_RS07165	COG1648	precorrin-2 dehydrogenase activity
EXW25_RS07170	COG0733	neurotransmitter:sodium symporter activity
EXW25_RS07195	COG1757	Na H antiporter
EXW25_RS07210	COG4758	membrane
EXW25_RS07215	COG4585	Histidine kinase
EXW25_RS07220	COG2197	response regulator
EXW25_RS07230	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS07240	COG2226	methyltransferase
EXW25_RS07280	COG0730	response to heat
EXW25_RS07285	COG0306	phosphate transporter
EXW25_RS07290	COG1392	Phosphate transport regulator
EXW25_RS07295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS07310	COG3852	Histidine kinase
EXW25_RS07315	COG1801	Protein of unknown function DUF72
EXW25_RS07325	COG0582	viral genome integration into host DNA
EXW25_RS07330	COG5002	protein histidine kinase activity
EXW25_RS07345	COG0392	lysyltransferase activity
EXW25_RS07345	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW25_RS07360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW25_RS07365	COG1686	Belongs to the peptidase S11 family
EXW25_RS07370	COG2715	membrane protein required for spore maturation
EXW25_RS07375	COG0700	Nucleoside recognition
EXW25_RS07380	COG1187	pseudouridine synthase activity
EXW25_RS07390	COG1333	cytochrome c biogenesis protein
EXW25_RS07395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW25_RS07400	COG0745	RESPONSE REGULATOR receiver
EXW25_RS07405	COG5002	protein histidine kinase activity
EXW25_RS07410	COG2096	Adenosyltransferase
EXW25_RS07415	COG4942	peptidase
EXW25_RS07425	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW25_RS07430	COG1141	Ferredoxin
EXW25_RS07435	COG4955	Helix-turn-helix domain
EXW25_RS07440	COG0514	ATP-dependent DNA helicase (RecQ)
EXW25_RS07445	COG1266	CAAX protease self-immunity
EXW25_RS07455	COG1408	metallophosphoesterase
EXW25_RS07460	COG0789	Transcriptional regulator
EXW25_RS07465	COG4862	establishment of competence for transformation
EXW25_RS07470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW25_RS07490	COG0492	ferredoxin-NADP+ reductase activity
EXW25_RS07495	COG0252	asparaginase activity
EXW25_RS07565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW25_RS07580	COG0142	geranyltranstransferase activity
EXW25_RS07590	COG0142	geranyltranstransferase activity
EXW25_RS07615	COG0457	Tetratricopeptide repeat
EXW25_RS07635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW25_RS07640	COG2010	Cytochrome c
EXW25_RS07640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW25_RS07645	COG4347	Protein of unknown function (DUF1405)
EXW25_RS07660	COG2738	Putative neutral zinc metallopeptidase
EXW25_RS07670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS07675	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW25_RS07690	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW25_RS07695	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS07730	COG1199	ATP-dependent helicase activity
EXW25_RS07730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW25_RS07750	COG3935	DnaD domain protein
EXW25_RS07755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW25_RS07765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS07765	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW25_RS07810	COG3599	regulation of cell shape
EXW25_RS07820	COG0116	Belongs to the methyltransferase superfamily
EXW25_RS07830	COG1199	ATP-dependent helicase activity
EXW25_RS07835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW25_RS07845	COG3173	Aminoglycoside phosphotransferase
EXW25_RS07850	COG0024	Methionine aminopeptidase
EXW25_RS07860	COG2233	PERMEase
EXW25_RS07865	COG2311	Membrane
EXW25_RS07875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW25_RS07885	COG0456	acetyltransferase
EXW25_RS07925	COG0754	glutathionylspermidine amidase activity
EXW25_RS07940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW25_RS07955	COG0454	-acetyltransferase
EXW25_RS07975	COG0328	RNA-DNA hybrid ribonuclease activity
EXW25_RS08010	COG3403	YqcI/YcgG family
EXW25_RS08015	COG1280	lysine exporter protein (LysE YggA)
EXW25_RS08030	COG3162	membrane
EXW25_RS08035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW25_RS08040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW25_RS08050	COG0475	glutathione-regulated potassium exporter activity
EXW25_RS08055	COG4978	Transcriptional regulator
EXW25_RS08055	COG0789	Transcriptional regulator
EXW25_RS08065	COG2323	membrane
EXW25_RS08070	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW25_RS08100	COG2814	Major facilitator Superfamily
EXW25_RS08120	COG1923	regulation of RNA biosynthetic process
EXW25_RS08130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW25_RS08135	COG1360	Flagellar Motor Protein
EXW25_RS08140	COG2201	protein-glutamate methylesterase activity
EXW25_RS08145	COG2198	Histidine kinase
EXW25_RS08145	COG0643	Histidine kinase
EXW25_RS08150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW25_RS08150	COG1776	CheC inhibitor of MCP methylation
EXW25_RS08165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW25_RS08185	COG1256	bacterial-type flagellum assembly
EXW25_RS08190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW25_RS08195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EXW25_RS08210	COG1815	bacterial-type flagellum-dependent cell motility
EXW25_RS08215	COG1558	bacterial-type flagellum-dependent cell motility
EXW25_RS08225	COG1766	The M ring may be actively involved in energy transduction
EXW25_RS08230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW25_RS08240	COG1157	protein secretion by the type III secretion system
EXW25_RS08260	COG1749	Flagellar hook protein flgE
EXW25_RS08275	COG0835	chemotaxis
EXW25_RS08275	COG0784	Response regulator, receiver
EXW25_RS08285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW25_RS08290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW25_RS08295	COG0741	lytic transglycosylase activity
EXW25_RS08305	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW25_RS08310	COG1776	CheC inhibitor of MCP methylation
EXW25_RS08310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW25_RS08320	COG1338	Plays a role in the flagellum-specific transport system
EXW25_RS08325	COG1987	bacterial-type flagellum assembly
EXW25_RS08335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW25_RS08340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW25_RS08345	COG1419	protein localization to endoplasmic reticulum
EXW25_RS08350	COG4786	Flagellar basal body rod
EXW25_RS08390	COG2329	Antibiotic biosynthesis monooxygenase
EXW25_RS08405	COG2814	Major facilitator Superfamily
EXW25_RS08415	COG0583	DNA-binding transcription factor activity
EXW25_RS08420	COG3842	ATPase activity
EXW25_RS08425	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW25_RS08430	COG1177	transmembrane transport
EXW25_RS08470	COG0406	alpha-ribazole phosphatase activity
EXW25_RS08490	COG1846	Transcriptional regulator
EXW25_RS08500	COG0367	asparagine synthase
EXW25_RS08530	COG1802	Transcriptional regulator
EXW25_RS08535	COG0697	spore germination
EXW25_RS08545	COG0523	cobalamin synthesis protein
EXW25_RS08550	COG1216	Glycosyl transferase, family 2
EXW25_RS08550	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS08555	COG1757	Na H antiporter
EXW25_RS08560	COG0789	Transcriptional regulator
EXW25_RS08565	COG4221	oxidoreductase activity
EXW25_RS08585	COG0534	Mate efflux family protein
EXW25_RS08590	COG3340	Belongs to the peptidase S51 family
EXW25_RS08610	COG0785	Cytochrome C biogenesis protein
EXW25_RS08615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW25_RS08635	COG2733	membrane
EXW25_RS08670	COG1131	(ABC) transporter
EXW25_RS08690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW25_RS08695	COG0528	UMP kinase activity
EXW25_RS08705	COG1027	Aspartate ammonia-lyase
EXW25_RS08710	COG0281	malic enzyme
EXW25_RS08715	COG4191	Histidine kinase
EXW25_RS08720	COG0784	Response regulator, receiver
EXW25_RS08725	COG1846	Transcriptional regulator
EXW25_RS08735	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW25_RS08780	COG2814	Major facilitator Superfamily
EXW25_RS08800	COG0477	Major facilitator Superfamily
EXW25_RS08805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW25_RS08815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW25_RS08820	COG2223	nitrite transmembrane transporter activity
EXW25_RS08825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW25_RS08840	COG2244	polysaccharide biosynthetic process
EXW25_RS08845	COG0733	neurotransmitter:sodium symporter activity
EXW25_RS08855	COG5566	PFAM Mor transcription activator
EXW25_RS08860	COG2323	membrane
EXW25_RS08880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW25_RS08890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS08895	COG0028	Belongs to the TPP enzyme family
EXW25_RS08915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW25_RS08935	COG2814	Major facilitator Superfamily
EXW25_RS08940	COG3384	dioxygenase
EXW25_RS08950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW25_RS08970	COG4166	transmembrane transport
EXW25_RS08980	COG0535	radical SAM domain protein
EXW25_RS08985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS09005	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW25_RS09020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW25_RS09025	COG0531	amino acid
EXW25_RS09050	COG1266	CAAX protease self-immunity
EXW25_RS09055	COG1309	transcriptional regulator
EXW25_RS09060	COG2390	Transcriptional regulator
EXW25_RS09070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS09075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW25_RS09080	COG0295	cytidine deaminase activity
EXW25_RS09110	COG0583	DNA-binding transcription factor activity
EXW25_RS09125	COG0006	proline dipeptidase activity
EXW25_RS09130	COG2132	Multicopper oxidase
EXW25_RS09175	COG1760	l-serine dehydratase
EXW25_RS09180	COG1760	l-serine dehydratase
EXW25_RS09185	COG0814	amino acid
EXW25_RS09200	COG3615	Tellurite resistance protein tehB
EXW25_RS09200	COG0500	methyltransferase
EXW25_RS09215	COG1073	alpha beta
EXW25_RS09285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW25_RS09360	COG0464	growth
EXW25_RS09465	COG0583	DNA-binding transcription factor activity
EXW25_RS09485	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS09495	COG2372	response to copper ion
EXW25_RS09495	COG1276	copper resistance
EXW25_RS09500	COG4549	nuclear export factor GLE1
EXW25_RS09505	COG0697	spore germination
EXW25_RS09510	COG0583	DNA-binding transcription factor activity
EXW25_RS09515	COG1959	2 iron, 2 sulfur cluster binding
EXW25_RS09520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW25_RS09535	COG0628	permease
EXW25_RS09550	COG1231	oxidoreductase activity
EXW25_RS09555	COG0523	cobalamin synthesis protein
EXW25_RS09565	COG0411	ABC transporter
EXW25_RS09575	COG0559	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS09585	COG0583	DNA-binding transcription factor activity
EXW25_RS09610	COG0346	lactoylglutathione lyase activity
EXW25_RS09620	COG1271	oxidase subunit
EXW25_RS09625	COG1294	oxidase, subunit
EXW25_RS09630	COG4988	ABC transporter
EXW25_RS09635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW25_RS09640	COG0463	Glycosyl transferase, family 2
EXW25_RS09660	COG1686	Belongs to the peptidase S11 family
EXW25_RS09675	COG1388	LysM domain
EXW25_RS09675	COG0791	NLP P60 protein
EXW25_RS09685	COG1132	(ABC) transporter
EXW25_RS09690	COG0745	RESPONSE REGULATOR receiver
EXW25_RS09695	COG5002	protein histidine kinase activity
EXW25_RS09700	COG0300	oxidoreductase activity
EXW25_RS09705	COG4122	O-methyltransferase activity
EXW25_RS09720	COG5658	integral membrane protein
EXW25_RS09735	COG0460	homoserine dehydrogenase
EXW25_RS09745	COG0083	homoserine kinase activity
EXW25_RS09760	COG1316	TRANSCRIPTIONal
EXW25_RS09770	COG0745	RESPONSE REGULATOR receiver
EXW25_RS09775	COG5002	protein histidine kinase activity
EXW25_RS09790	COG1285	pathogenesis
EXW25_RS09795	COG1247	-acetyltransferase
EXW25_RS09815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW25_RS09825	COG1082	Xylose isomerase domain protein TIM barrel
EXW25_RS09835	COG2814	Major facilitator Superfamily
EXW25_RS09840	COG1279	arginine transmembrane transporter activity
EXW25_RS09845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS09855	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW25_RS09890	COG0577	efflux transmembrane transporter activity
EXW25_RS09895	COG2002	toxin-antitoxin pair type II binding
EXW25_RS09900	COG1404	Belongs to the peptidase S8 family
EXW25_RS09905	COG0640	Transcriptional regulator
EXW25_RS09910	COG0667	Aldo Keto reductase
EXW25_RS09955	COG3949	Membrane
EXW25_RS09960	COG0783	Belongs to the Dps family
EXW25_RS09975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW25_RS09985	COG1231	oxidoreductase activity
EXW25_RS09990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS09995	COG4989	oxidoreductase activity
EXW25_RS10000	COG0523	cobalamin synthesis protein
EXW25_RS10010	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW25_RS10020	COG0702	epimerase
EXW25_RS10030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW25_RS10040	COG4166	transmembrane transport
EXW25_RS10045	COG0346	lactoylglutathione lyase activity
EXW25_RS10055	COG0406	alpha-ribazole phosphatase activity
EXW25_RS10065	COG5337	Spore coat protein CotH
EXW25_RS10070	COG1051	belongs to the nudix hydrolase family
EXW25_RS10075	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS10080	COG2244	polysaccharide biosynthetic process
EXW25_RS10090	COG0701	Predicted permease
EXW25_RS10095	COG3689	TIGRFAM TIGR03943 family protein
EXW25_RS10100	COG1607	acyl-coa hydrolase
EXW25_RS10110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW25_RS10125	COG0702	epimerase
EXW25_RS10130	COG2839	Protein conserved in bacteria
EXW25_RS10135	COG1253	flavin adenine dinucleotide binding
EXW25_RS10150	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS10155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW25_RS10170	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS10180	COG1876	peptidase activity
EXW25_RS10190	COG0154	amidase activity
EXW25_RS10195	COG2211	Major facilitator Superfamily
EXW25_RS10210	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS10220	COG0561	phosphatase activity
EXW25_RS10225	COG1846	Transcriptional regulator
EXW25_RS10230	COG2814	Major facilitator Superfamily
EXW25_RS10240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW25_RS10255	COG1819	glycosyl
EXW25_RS10260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS10265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS10290	COG0456	acetyltransferase
EXW25_RS10390	COG3874	Sporulation protein YtfJ
EXW25_RS10415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW25_RS10435	COG0346	lactoylglutathione lyase activity
EXW25_RS10450	COG1595	DNA-templated transcription, initiation
EXW25_RS10470	COG0426	domain, Protein
EXW25_RS10470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW25_RS10480	COG0386	Belongs to the glutathione peroxidase family
EXW25_RS10485	COG1305	Transglutaminase-like
EXW25_RS10490	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW25_RS10495	COG0714	Associated with various cellular activities
EXW25_RS10510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW25_RS10515	COG1140	nitrate reductase beta subunit
EXW25_RS10520	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW25_RS10525	COG2181	nitrate reductase activity
EXW25_RS10530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW25_RS10535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW25_RS10540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW25_RS10545	COG0303	'Molybdopterin
EXW25_RS10550	COG0314	molybdopterin synthase activity
EXW25_RS10560	COG2223	nitrite transmembrane transporter activity
EXW25_RS10570	COG1648	precorrin-2 dehydrogenase activity
EXW25_RS10580	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW25_RS10580	COG1587	Uroporphyrinogen-III synthase
EXW25_RS10585	COG2146	nitrite reductase [NAD(P)H] activity
EXW25_RS10590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW25_RS10595	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW25_RS10625	COG2359	stage V sporulation protein S
EXW25_RS10635	COG2856	Zn peptidase
EXW25_RS10650	COG1396	sequence-specific DNA binding
EXW25_RS10740	COG0582	viral genome integration into host DNA
EXW25_RS10790	COG1783	phage Terminase large subunit
EXW25_RS10805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EXW25_RS10810	COG4653	Phage capsid family
EXW25_RS10930	COG0457	Tetratricopeptide repeat
EXW25_RS10945	COG1418	mRNA catabolic process
EXW25_RS10950	COG0488	(ABC) transporter
EXW25_RS10965	COG0629	single-stranded DNA binding
EXW25_RS10980	COG1413	lyase activity
EXW25_RS10995	COG2136	Putative SAM-dependent methyltransferase
EXW25_RS10995	COG2521	methyltransferase
EXW25_RS11000	COG0018	arginyl-trna synthetase
EXW25_RS11040	COG0017	Asparaginyl-tRNA synthetase
EXW25_RS11045	COG0733	neurotransmitter:sodium symporter activity
EXW25_RS11070	COG2610	gluconate transmembrane transporter activity
EXW25_RS11080	COG1794	racemase activity, acting on amino acids and derivatives
EXW25_RS11090	COG0456	acetyltransferase
EXW25_RS11095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW25_RS11105	COG1131	(ABC) transporter
EXW25_RS11110	COG4473	ABC transporter
EXW25_RS11120	COG0546	phosphoglycolate phosphatase activity
EXW25_RS11150	COG0768	penicillin binding
EXW25_RS11160	COG0204	Acyl-transferase
EXW25_RS11165	COG1272	protein, Hemolysin III
EXW25_RS11175	COG0805	protein transport
EXW25_RS11185	COG1307	EDD domain protein, DegV family
EXW25_RS11190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW25_RS11195	COG1999	signal sequence binding
EXW25_RS11200	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW25_RS11205	COG0367	asparagine synthase
EXW25_RS11220	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS11225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS11230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS11245	COG1335	isochorismatase
EXW25_RS11250	COG1051	belongs to the nudix hydrolase family
EXW25_RS11255	COG0668	transmembrane transport
EXW25_RS11260	COG2203	Gaf domain
EXW25_RS11260	COG4585	Histidine kinase
EXW25_RS11265	COG2197	response regulator
EXW25_RS11270	COG1737	Transcriptional regulator
EXW25_RS11275	COG1064	alcohol dehydrogenase
EXW25_RS11335	COG1125	glycine betaine transport
EXW25_RS11335	COG0517	IMP dehydrogenase activity
EXW25_RS11340	COG1174	glycine betaine transport
EXW25_RS11375	COG1253	flavin adenine dinucleotide binding
EXW25_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS11385	COG5506	Protein of unknown function (DUF1694)
EXW25_RS11400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW25_RS11405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW25_RS11410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW25_RS11415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW25_RS11420	COG0456	acetyltransferase
EXW25_RS11425	COG3829	transcription factor binding
EXW25_RS11430	COG1509	lysine 2,3-aminomutase activity
EXW25_RS11465	COG3064	Membrane
EXW25_RS11465	COG4991	sh3 domain protein
EXW25_RS11465	COG0515	serine threonine protein kinase
EXW25_RS11475	COG0671	phosphoesterase, PA-phosphatase related
EXW25_RS11480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW25_RS11485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW25_RS11600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW25_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS11645	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW25_RS11645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS11655	COG2814	Major facilitator Superfamily
EXW25_RS11665	COG0372	Belongs to the citrate synthase family
EXW25_RS11670	COG2079	MmgE PrpD family protein
EXW25_RS11675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW25_RS11680	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS11685	COG2084	Dehydrogenase
EXW25_RS11695	COG1280	lysine exporter protein (LysE YggA)
EXW25_RS11700	COG1024	Enoyl-CoA hydratase
EXW25_RS11715	COG0420	3'-5' exonuclease activity
EXW25_RS11745	COG2223	nitrite transmembrane transporter activity
EXW25_RS11750	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS11755	COG1169	isochorismate synthase
EXW25_RS11760	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW25_RS11765	COG1535	isochorismatase
EXW25_RS11765	COG3433	isochorismatase activity
EXW25_RS11770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW25_RS11775	COG3251	PFAM MbtH domain protein
EXW25_RS11780	COG2814	Major facilitator Superfamily
EXW25_RS11795	COG0776	regulation of translation
EXW25_RS11805	COG2318	DinB family
EXW25_RS11825	COG1115	amino acid carrier protein
EXW25_RS11840	COG1187	pseudouridine synthase activity
EXW25_RS11845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW25_RS11850	COG1136	(ABC) transporter
EXW25_RS11860	COG0596	Alpha beta hydrolase
EXW25_RS11875	COG0028	Belongs to the TPP enzyme family
EXW25_RS11915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW25_RS11925	COG2207	Transcriptional regulator
EXW25_RS11950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW25_RS11950	COG2755	lipolytic protein G-D-S-L family
EXW25_RS11960	COG5002	protein histidine kinase activity
EXW25_RS11970	COG0745	RESPONSE REGULATOR receiver
EXW25_RS12005	COG1309	transcriptional regulator
EXW25_RS12030	COG1247	-acetyltransferase
EXW25_RS12055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW25_RS12065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS12095	COG0583	DNA-binding transcription factor activity
EXW25_RS12100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW25_RS12105	COG0583	DNA-binding transcription factor activity
EXW25_RS12110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW25_RS12115	COG2258	MOSC domain
EXW25_RS12130	COG1132	(ABC) transporter
EXW25_RS12135	COG1132	(ABC) transporter
EXW25_RS12160	COG1396	sequence-specific DNA binding
EXW25_RS12200	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW25_RS12205	COG1595	DNA-templated transcription, initiation
EXW25_RS12215	COG4122	O-methyltransferase activity
EXW25_RS12230	COG1649	PFAM Uncharacterised BCR, COG1649
EXW25_RS12250	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW25_RS12255	COG2971	BadF BadG BcrA BcrD
EXW25_RS12285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS12305	COG0500	methyltransferase
EXW25_RS12305	COG3615	Tellurite resistance protein tehB
EXW25_RS12315	COG2226	methyltransferase
EXW25_RS12320	COG3961	Belongs to the TPP enzyme family
EXW25_RS12355	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW25_RS12385	COG2002	toxin-antitoxin pair type II binding
EXW25_RS12395	COG0730	response to heat
EXW25_RS12405	COG1686	Belongs to the peptidase S11 family
EXW25_RS12430	COG1115	amino acid carrier protein
EXW25_RS12435	COG2066	Belongs to the glutaminase family
EXW25_RS12440	COG4191	Histidine kinase
EXW25_RS12445	COG0784	Response regulator, receiver
EXW25_RS12450	COG0697	spore germination
EXW25_RS12455	COG0531	amino acid
EXW25_RS12465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW25_RS12470	COG0531	amino acid
EXW25_RS12475	COG0322	excinuclease ABC activity
EXW25_RS12490	COG1396	sequence-specific DNA binding
EXW25_RS12495	COG0252	asparaginase activity
EXW25_RS12500	COG1027	Aspartate ammonia-lyase
EXW25_RS12510	COG0768	penicillin binding
EXW25_RS12515	COG1595	DNA-templated transcription, initiation
EXW25_RS12530	COG0768	penicillin binding
EXW25_RS12540	COG1408	metallophosphoesterase
EXW25_RS12550	COG1131	(ABC) transporter
EXW25_RS12560	COG1309	transcriptional regulator
EXW25_RS12575	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS12580	COG0439	Biotin carboxylase
EXW25_RS12585	COG0511	ligase activity, forming carbon-carbon bonds
EXW25_RS12590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW25_RS12595	COG1024	Enoyl-CoA hydratase
EXW25_RS12600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW25_RS12605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW25_RS12660	COG2318	DinB family
EXW25_RS12665	COG1686	Belongs to the peptidase S11 family
EXW25_RS12690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW25_RS12710	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS12715	COG2207	Transcriptional regulator
EXW25_RS12745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW25_RS12765	COG0789	Transcriptional regulator
EXW25_RS12775	COG1733	regulation of RNA biosynthetic process
EXW25_RS12790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW25_RS12800	COG1942	4-Oxalocrotonate Tautomerase
EXW25_RS12805	COG0583	DNA-binding transcription factor activity
EXW25_RS12815	COG1131	(ABC) transporter
EXW25_RS12825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW25_RS12845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS12870	COG2323	membrane
EXW25_RS12880	COG0693	protein deglycase activity
EXW25_RS12890	COG3386	PFAM SMP-30 Gluconolaconase
EXW25_RS12900	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW25_RS12905	COG3773	Cell wall hydrolase
EXW25_RS12915	COG0745	RESPONSE REGULATOR receiver
EXW25_RS12920	COG2205	protein histidine kinase activity
EXW25_RS12935	COG0667	Aldo Keto reductase
EXW25_RS12940	COG0488	(ABC) transporter
EXW25_RS12950	COG1136	(ABC) transporter
EXW25_RS12955	COG0577	efflux transmembrane transporter activity
EXW25_RS12975	COG0460	homoserine dehydrogenase
EXW25_RS12980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS12990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW25_RS13135	COG2124	cytochrome p450
EXW25_RS13170	COG0561	phosphatase activity
EXW25_RS13175	COG5002	protein histidine kinase activity
EXW25_RS13180	COG0768	penicillin binding
EXW25_RS13190	COG1819	glycosyl
EXW25_RS13195	COG1794	racemase activity, acting on amino acids and derivatives
EXW25_RS13220	COG2205	protein histidine kinase activity
EXW25_RS13230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW25_RS13240	COG0745	RESPONSE REGULATOR receiver
EXW25_RS13245	COG5002	protein histidine kinase activity
EXW25_RS13250	COG0604	alcohol dehydrogenase
EXW25_RS13255	COG0671	phosphoesterase, PA-phosphatase related
EXW25_RS13260	COG0768	penicillin binding
EXW25_RS13320	COG2814	Major facilitator Superfamily
EXW25_RS13335	COG0584	glycerophosphoryl diester phosphodiesterase
EXW25_RS13355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS13360	COG0697	spore germination
EXW25_RS13390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW25_RS13400	COG2223	nitrite transmembrane transporter activity
EXW25_RS13410	COG2816	NAD+ diphosphatase activity
EXW25_RS13415	COG0592	DNA-directed DNA polymerase activity
EXW25_RS13445	COG3878	Protein conserved in bacteria
EXW25_RS13470	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW25_RS13510	COG0322	excinuclease ABC activity
EXW25_RS13540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW25_RS13565	COG1011	Hydrolase
EXW25_RS13570	COG0745	RESPONSE REGULATOR receiver
EXW25_RS13575	COG5002	protein histidine kinase activity
EXW25_RS13605	COG1136	(ABC) transporter
EXW25_RS13610	COG0577	efflux transmembrane transporter activity
EXW25_RS13625	COG1073	alpha beta
EXW25_RS13630	COG1523	belongs to the glycosyl hydrolase 13 family
EXW25_RS13635	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS13640	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS13650	COG0201	protein transport
EXW25_RS13655	COG0697	spore germination
EXW25_RS13660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS13695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS13710	COG2959	enzyme of heme biosynthesis
EXW25_RS13750	COG1309	transcriptional regulator
EXW25_RS13760	COG3284	Transcriptional regulator
EXW25_RS13780	COG1349	DNA-binding transcription factor activity
EXW25_RS13800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW25_RS13805	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW25_RS13810	COG0022	dehydrogenase e1 component
EXW25_RS13815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW25_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS13830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW25_RS13830	COG0456	acetyltransferase
EXW25_RS13870	COG4176	ABC-type proline glycine betaine transport system permease component
EXW25_RS13875	COG0517	IMP dehydrogenase activity
EXW25_RS13875	COG4175	Glycine betaine
EXW25_RS13905	COG2153	protein acetylation
EXW25_RS13920	COG3397	chitin binding
EXW25_RS13930	COG1819	glycosyl
EXW25_RS13950	COG2205	protein histidine kinase activity
EXW25_RS13955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW25_RS13960	COG2315	Protein conserved in bacteria
EXW25_RS14010	COG3973	AAA domain
EXW25_RS14015	COG2105	PFAM AIG2 family protein
EXW25_RS14020	COG0514	ATP-dependent DNA helicase (RecQ)
EXW25_RS14050	COG4637	Psort location Cytoplasmic, score
EXW25_RS14065	COG3397	chitin binding
EXW25_RS14070	COG2318	DinB family
EXW25_RS14085	COG1162	GTPase activity
EXW25_RS14090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW25_RS14095	COG1115	amino acid carrier protein
EXW25_RS14100	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS14105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW25_RS14110	COG3938	Belongs to the proline racemase family
EXW25_RS14115	COG3938	Belongs to the proline racemase family
EXW25_RS14120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW25_RS14125	COG2204	response regulator
EXW25_RS14170	COG1078	dGTPase activity
EXW25_RS14175	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS14185	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW25_RS14190	COG4166	transmembrane transport
EXW25_RS14200	COG4948	Mandelate Racemase Muconate Lactonizing
EXW25_RS14245	COG2936	dipeptidyl-peptidase activity
EXW25_RS14250	COG3850	Histidine kinase
EXW25_RS14250	COG5002	protein histidine kinase activity
EXW25_RS14280	COG1164	Oligoendopeptidase f
EXW25_RS14285	COG0456	acetyltransferase
EXW25_RS14290	COG1307	EDD domain protein, DegV family
EXW25_RS14330	COG2814	Major facilitator Superfamily
EXW25_RS14340	COG1664	Polymer-forming cytoskeletal
EXW25_RS14345	COG0789	Transcriptional regulator
EXW25_RS14350	COG4533	DNA binding
EXW25_RS14355	COG2814	Major facilitator Superfamily
EXW25_RS14355	COG0477	Major facilitator Superfamily
EXW25_RS14380	COG2261	transglycosylase associated protein
EXW25_RS14395	COG2226	methyltransferase
EXW25_RS14430	COG0436	Aminotransferase
EXW25_RS14435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW25_RS14445	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW25_RS14460	COG1131	(ABC) transporter
EXW25_RS14505	COG0628	permease
EXW25_RS14515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW25_RS14520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW25_RS14525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW25_RS14555	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW25_RS14590	COG0697	spore germination
EXW25_RS14625	COG0346	lactoylglutathione lyase activity
EXW25_RS14630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS14655	COG2814	Major facilitator Superfamily
EXW25_RS14660	COG0861	Integral membrane protein TerC family
EXW25_RS14665	COG1368	sulfuric ester hydrolase activity
EXW25_RS14670	COG0488	(ABC) transporter
EXW25_RS14675	COG1033	growth of symbiont in host cell
EXW25_RS14675	COG2409	Drug exporters of the RND superfamily
EXW25_RS14680	COG1309	transcriptional regulator
EXW25_RS14695	COG0287	Prephenate dehydrogenase
EXW25_RS14710	COG1605	Chorismate mutase
EXW25_RS14710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW25_RS14755	COG1388	LysM domain
EXW25_RS14755	COG3584	3D domain protein
EXW25_RS14765	COG0346	lactoylglutathione lyase activity
EXW25_RS14770	COG0519	Catalyzes the synthesis of GMP from XMP
EXW25_RS14775	COG0431	NADPH-dependent FMN reductase
EXW25_RS14795	COG1879	ABC-type sugar transport system periplasmic component
EXW25_RS14800	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS14805	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS14815	COG2390	Transcriptional regulator
EXW25_RS14820	COG1070	Carbohydrate kinase
EXW25_RS14850	COG2329	Antibiotic biosynthesis monooxygenase
EXW25_RS14870	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW25_RS14875	COG2207	Transcriptional regulator
EXW25_RS14880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS14885	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW25_RS14890	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW25_RS14895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW25_RS14900	COG4187	Peptidase family M20/M25/M40
EXW25_RS14905	COG1414	Transcriptional regulator
EXW25_RS14910	COG0833	amino acid
EXW25_RS14920	COG3239	Fatty acid desaturase
EXW25_RS14930	COG1785	Belongs to the alkaline phosphatase family
EXW25_RS14940	COG3655	Transcriptional regulator
EXW25_RS14965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS14970	COG0346	lactoylglutathione lyase activity
EXW25_RS14990	COG0714	Associated with various cellular activities
EXW25_RS15015	COG0753	catalase activity
EXW25_RS15055	COG0714	Associated with various cellular activities
EXW25_RS15085	COG0778	Nitroreductase
EXW25_RS15090	COG1846	Transcriptional regulator
EXW25_RS15110	COG4884	unkown
EXW25_RS15110	COG3831	ATPase activity
EXW25_RS15145	COG0456	acetyltransferase
EXW25_RS15165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS15180	COG0642	Histidine kinase
EXW25_RS15185	COG0745	RESPONSE REGULATOR receiver
EXW25_RS15190	COG0596	Alpha beta hydrolase
EXW25_RS15225	COG0730	response to heat
EXW25_RS15235	COG0833	amino acid
EXW25_RS15245	COG4335	DNA alkylation repair
EXW25_RS15275	COG0768	penicillin binding
EXW25_RS15305	COG1984	allophanate hydrolase subunit 2
EXW25_RS15310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW25_RS15315	COG1414	Transcriptional regulator
EXW25_RS15330	COG3142	Participates in the control of copper homeostasis
EXW25_RS15340	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS15355	COG3314	Sporulation integral membrane protein YlbJ
EXW25_RS15385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW25_RS15405	COG3848	Pyruvate phosphate dikinase
EXW25_RS15405	COG0574	Belongs to the PEP-utilizing enzyme family
EXW25_RS15415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS15440	COG1063	alcohol dehydrogenase
EXW25_RS15450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW25_RS15460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW25_RS15475	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS15480	COG2267	carboxylic ester hydrolase activity
EXW25_RS15485	COG1335	isochorismatase
EXW25_RS15505	COG0583	DNA-binding transcription factor activity
EXW25_RS15515	COG0598	Magnesium transport protein CorA
EXW25_RS15550	COG0415	Belongs to the DNA photolyase family
EXW25_RS15555	COG0288	reversible hydration of carbon dioxide
EXW25_RS15565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW25_RS15570	COG5609	conserved protein (DUF2294)
EXW25_RS15575	COG2814	Major facilitator Superfamily
EXW25_RS15580	COG0583	DNA-binding transcription factor activity
EXW25_RS15605	COG5002	protein histidine kinase activity
EXW25_RS15610	COG0745	RESPONSE REGULATOR receiver
EXW25_RS15615	COG0456	acetyltransferase
EXW25_RS15620	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW25_RS15665	COG1329	Transcriptional regulator
EXW25_RS15680	COG2962	Rard protein
EXW25_RS15690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW25_RS15705	COG4641	Protein conserved in bacteria
EXW25_RS15720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS15730	COG0798	PFAM Bile acid sodium symporter
EXW25_RS15735	COG0346	lactoylglutathione lyase activity
EXW25_RS15740	COG0640	Transcriptional regulator
EXW25_RS15765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW25_RS15765	COG3320	Male sterility
EXW25_RS15770	COG1309	transcriptional regulator
EXW25_RS15775	COG2186	Transcriptional regulator
EXW25_RS15790	COG0814	amino acid
EXW25_RS15795	COG0697	spore germination
EXW25_RS15800	COG2814	Major facilitator Superfamily
EXW25_RS15805	COG1309	transcriptional regulator
EXW25_RS15810	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS15815	COG1522	sequence-specific DNA binding
EXW25_RS15830	COG0346	lactoylglutathione lyase activity
EXW25_RS15895	COG0384	phenazine biosynthesis protein PhzF
EXW25_RS15900	COG2814	Major facilitator Superfamily
EXW25_RS15915	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW25_RS15930	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW25_RS15955	COG0577	efflux transmembrane transporter activity
EXW25_RS15965	COG5002	protein histidine kinase activity
EXW25_RS15965	COG3850	Histidine kinase
EXW25_RS15975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS15990	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW25_RS16010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW25_RS16065	COG2814	Major facilitator Superfamily
EXW25_RS16170	COG1876	peptidase activity
EXW25_RS16175	COG2843	Capsule synthesis protein
EXW25_RS16185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW25_RS16190	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS16200	COG0534	Mate efflux family protein
EXW25_RS16205	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW25_RS16225	COG0477	Major facilitator Superfamily
EXW25_RS16240	COG1846	Transcriptional regulator
EXW25_RS16245	COG2814	Major facilitator Superfamily
EXW25_RS16270	COG2031	fatty acid transporter
EXW25_RS16280	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW25_RS16335	COG1288	antiporter activity
EXW25_RS16340	COG2356	endonuclease I
EXW25_RS16350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW25_RS16355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW25_RS16375	COG1733	regulation of RNA biosynthetic process
EXW25_RS16380	COG0778	Nitroreductase
EXW25_RS16410	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS16420	COG1131	(ABC) transporter
EXW25_RS16445	COG1011	Hydrolase
EXW25_RS16455	COG2365	Tyrosine phosphatase family
EXW25_RS16485	COG0628	permease
EXW25_RS16515	COG0477	Major facilitator Superfamily
EXW25_RS16535	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW25_RS16545	COG1253	flavin adenine dinucleotide binding
EXW25_RS16550	COG0789	Transcriptional regulator
EXW25_RS16560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW25_RS16585	COG0697	spore germination
EXW25_RS16590	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW25_RS16595	COG3813	Protein conserved in bacteria
EXW25_RS16600	COG2706	6-phosphogluconolactonase activity
EXW25_RS16605	COG1070	Carbohydrate kinase
EXW25_RS16620	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW25_RS16630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW25_RS16670	COG0346	lactoylglutathione lyase activity
EXW25_RS16675	COG0814	amino acid
EXW25_RS16680	COG3655	Transcriptional regulator
EXW25_RS16710	COG1393	Belongs to the ArsC family
EXW25_RS16715	COG1733	regulation of RNA biosynthetic process
EXW25_RS16720	COG2188	Transcriptional regulator
EXW25_RS16725	COG0673	inositol 2-dehydrogenase activity
EXW25_RS16745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS16775	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS16790	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS16795	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW25_RS16800	COG1733	regulation of RNA biosynthetic process
EXW25_RS16815	COG0640	Transcriptional regulator
EXW25_RS16840	COG1191	sigma factor activity
EXW25_RS16850	COG1280	lysine exporter protein (LysE YggA)
EXW25_RS16885	COG3152	Membrane
EXW25_RS16915	COG1151	hydroxylamine reductase activity
EXW25_RS16945	COG2072	flavoprotein involved in K transport
EXW25_RS16980	COG0604	alcohol dehydrogenase
EXW25_RS16985	COG1113	amino acid transport
EXW25_RS16995	COG2814	Major facilitator Superfamily
EXW25_RS17050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW25_RS17055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW25_RS17070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS17075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS17080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS17085	COG3739	integral membrane protein
EXW25_RS17115	COG0583	DNA-binding transcription factor activity
EXW25_RS17140	COG1193	negative regulation of DNA recombination
EXW25_RS17150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW25_RS17155	COG1164	Oligoendopeptidase f
EXW25_RS17180	COG3781	membrane
EXW25_RS17195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW25_RS17210	COG0583	DNA-binding transcription factor activity
EXW25_RS17225	COG0584	glycerophosphoryl diester phosphodiesterase
EXW25_RS17235	COG0640	Transcriptional regulator
EXW25_RS17240	COG0604	alcohol dehydrogenase
EXW25_RS17250	COG0457	Tetratricopeptide repeat
EXW25_RS17260	COG2808	Putative FMN-binding domain
EXW25_RS17265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW25_RS17275	COG0277	FAD linked oxidase domain protein
EXW25_RS17300	COG0488	(ABC) transporter
EXW25_RS17305	COG1876	peptidase activity
EXW25_RS17340	COG3852	Histidine kinase
EXW25_RS17350	COG1285	pathogenesis
EXW25_RS17360	COG2514	catechol 2,3-dioxygenase activity
EXW25_RS17365	COG2720	vancomycin resistance protein
EXW25_RS17400	COG0716	FMN binding
EXW25_RS17430	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS17440	COG0165	Argininosuccinate lyase
EXW25_RS17455	COG4145	pantothenate transmembrane transporter activity
EXW25_RS17465	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS17470	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS17480	COG1657	PFAM Prenyltransferase squalene oxidase
EXW25_RS17485	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW25_RS17490	COG2962	Rard protein
EXW25_RS17495	COG3326	Membrane
EXW25_RS17510	COG0489	protein tyrosine kinase activity
EXW25_RS17520	COG0314	molybdopterin synthase activity
EXW25_RS17525	COG0303	'Molybdopterin
EXW25_RS17530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW25_RS17535	COG2116	formate transmembrane transporter activity
EXW25_RS17545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW25_RS17550	COG5609	conserved protein (DUF2294)
EXW25_RS17555	COG2427	Protein of unknown function (DUF1641)
EXW25_RS17560	COG3383	formate dehydrogenase (NAD+) activity
EXW25_RS17565	COG0697	spore germination
EXW25_RS17580	COG0531	amino acid
EXW25_RS17615	COG2226	methyltransferase
EXW25_RS17620	COG4166	transmembrane transport
EXW25_RS17625	COG4166	transmembrane transport
EXW25_RS17630	COG4166	transmembrane transport
EXW25_RS17640	COG1316	TRANSCRIPTIONal
EXW25_RS17650	COG1595	DNA-templated transcription, initiation
EXW25_RS17660	COG1131	(ABC) transporter
EXW25_RS17670	COG0673	inositol 2-dehydrogenase activity
EXW25_RS17675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW25_RS17680	COG0187	DNA topoisomerase II activity
EXW25_RS17685	COG1832	CoA-binding protein
EXW25_RS17690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW25_RS17695	COG0745	RESPONSE REGULATOR receiver
EXW25_RS17705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW25_RS17705	COG1328	CTP reductase activity
EXW25_RS17715	COG4841	protein insertion into membrane
EXW25_RS17720	COG0824	Thioesterase
EXW25_RS17745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW25_RS17760	COG1132	(ABC) transporter
EXW25_RS17765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW25_RS17795	COG2211	Major facilitator Superfamily
EXW25_RS17805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW25_RS17820	COG0183	Belongs to the thiolase family
EXW25_RS17825	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS17830	COG1268	BioY protein
EXW25_RS17835	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS17840	COG1396	sequence-specific DNA binding
EXW25_RS17860	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EXW25_RS17880	COG0830	nickel cation binding
EXW25_RS17920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS17930	COG5002	protein histidine kinase activity
EXW25_RS17935	COG0400	carboxylic ester hydrolase activity
EXW25_RS17940	COG0346	lactoylglutathione lyase activity
EXW25_RS17945	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW25_RS17950	COG0069	glutamate synthase activity
EXW25_RS17955	COG1902	pentaerythritol trinitrate reductase activity
EXW25_RS17960	COG1329	Transcriptional regulator
EXW25_RS17965	COG0010	Belongs to the arginase family
EXW25_RS17990	COG2226	methyltransferase
EXW25_RS18015	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW25_RS18020	COG0785	Cytochrome C biogenesis protein
EXW25_RS18030	COG1473	amidohydrolase
EXW25_RS18040	COG1131	(ABC) transporter
EXW25_RS18055	COG0583	DNA-binding transcription factor activity
EXW25_RS18065	COG1346	cytolysis
EXW25_RS18080	COG0730	response to heat
EXW25_RS18105	COG1132	(ABC) transporter
EXW25_RS18110	COG1132	(ABC) transporter
EXW25_RS18115	COG3763	UPF0154 protein
EXW25_RS18135	COG3639	organic phosphonate transmembrane transporter activity
EXW25_RS18150	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS18160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW25_RS18180	COG1695	Transcriptional regulator
EXW25_RS18185	COG1132	(ABC) transporter
EXW25_RS18215	COG0367	asparagine synthase
EXW25_RS18220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW25_RS18230	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW25_RS18235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW25_RS18240	COG3420	alginic acid biosynthetic process
EXW25_RS18240	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW25_RS18265	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS18275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW25_RS18275	COG0463	Glycosyl transferase, family 2
EXW25_RS18280	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS18285	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS18290	COG1086	Polysaccharide biosynthesis protein
EXW25_RS18295	COG0489	protein tyrosine kinase activity
EXW25_RS18315	COG0741	lytic transglycosylase activity
EXW25_RS18315	COG1196	nuclear chromosome segregation
EXW25_RS18315	COG0739	heme binding
EXW25_RS18355	COG0174	glutamine synthetase
EXW25_RS18360	COG0789	Transcriptional regulator
EXW25_RS18365	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW25_RS18370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW25_RS18375	COG2860	membrane
EXW25_RS18385	COG0464	growth
EXW25_RS18420	COG1388	LysM domain
EXW25_RS18420	COG3584	3D domain protein
EXW25_RS18425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW25_RS18425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW25_RS18425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW25_RS18430	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW25_RS18435	COG1349	DNA-binding transcription factor activity
EXW25_RS18440	COG1979	alcohol dehydrogenase
EXW25_RS18445	COG2322	membrane
EXW25_RS18455	COG1113	amino acid transport
EXW25_RS18465	COG1473	amidohydrolase
EXW25_RS18470	COG1408	metallophosphoesterase
EXW25_RS18485	COG0454	-acetyltransferase
EXW25_RS18490	COG2217	Heavy metal translocating P-type atpase
EXW25_RS18495	COG2608	mercury ion transmembrane transporter activity
EXW25_RS18500	COG1937	Protein conserved in bacteria
EXW25_RS18510	COG2819	hydrolase of the alpha beta superfamily
EXW25_RS18515	COG1120	ATPase activity
EXW25_RS18520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS18525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS18530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS18535	COG0708	Exodeoxyribonuclease III
EXW25_RS18540	COG2169	Transcriptional regulator
EXW25_RS18545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW25_RS18550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW25_RS18560	COG2364	Membrane
EXW25_RS18580	COG5001	Diguanylate cyclase
EXW25_RS18580	COG3300	MHYT domain
EXW25_RS18620	COG1346	cytolysis
EXW25_RS18630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW25_RS18635	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW25_RS18635	COG0596	Alpha beta hydrolase
EXW25_RS18640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW25_RS18665	COG3773	Cell wall hydrolase
EXW25_RS18675	COG1368	sulfuric ester hydrolase activity
EXW25_RS18705	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW25_RS18715	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW25_RS18720	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW25_RS18720	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW25_RS18730	COG2359	stage V sporulation protein S
EXW25_RS18735	COG1692	metallophosphoesterase
EXW25_RS18740	COG1418	mRNA catabolic process
EXW25_RS18755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW25_RS18760	COG1426	Protein conserved in bacteria
EXW25_RS18775	COG0300	oxidoreductase activity
EXW25_RS18780	COG0612	Peptidase, M16
EXW25_RS18785	COG0612	Peptidase, M16
EXW25_RS18790	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS18795	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW25_RS18800	COG3845	ABC transporter
EXW25_RS18805	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW25_RS18810	COG2188	Transcriptional regulator
EXW25_RS18815	COG1674	ftsk spoiiie
EXW25_RS18825	COG0740	serine-type endopeptidase activity
EXW25_RS18830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW25_RS18840	COG0527	aspartate kinase activity
EXW25_RS18845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW25_RS18870	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS18995	COG0582	viral genome integration into host DNA
EXW25_RS19035	COG0305	Participates in initiation and elongation during chromosome replication
EXW25_RS19070	COG1396	sequence-specific DNA binding
EXW25_RS19105	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW25_RS19110	COG1873	PFAM PRC-barrel domain
EXW25_RS19115	COG0612	Peptidase, M16
EXW25_RS19120	COG0726	polysaccharide deacetylase
EXW25_RS19135	COG0196	riboflavin kinase activity
EXW25_RS19145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW25_RS19150	COG1550	Protein conserved in bacteria
EXW25_RS19160	COG1358	cellular component organization or biogenesis
EXW25_RS19165	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW25_RS19170	COG0195	Participates in both transcription termination and antitermination
EXW25_RS19190	COG0750	zinc metalloprotease
EXW25_RS19200	COG4589	Belongs to the CDS family
EXW25_RS19215	COG0528	UMP kinase activity
EXW25_RS19220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW25_RS19245	COG4974	Belongs to the 'phage' integrase family
EXW25_RS19255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW25_RS19260	COG0758	DNA mediated transformation
EXW25_RS19265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW25_RS19290	COG0335	large ribosomal subunit rRNA binding
EXW25_RS19305	COG1837	Belongs to the UPF0109 family
EXW25_RS19315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW25_RS19325	COG0552	protein localization to endoplasmic reticulum
EXW25_RS19330	COG1196	nuclear chromosome segregation
EXW25_RS19340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW25_RS19345	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS19350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW25_RS19365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW25_RS19370	COG1461	Dihydroxyacetone kinase
EXW25_RS19375	COG1302	Protein conserved in bacteria
EXW25_RS19390	COG1564	THIamine pyrophosphokinase
EXW25_RS19395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW25_RS19400	COG1162	GTPase activity
EXW25_RS19405	COG0515	serine threonine protein kinase
EXW25_RS19405	COG2815	serine threonine protein kinase
EXW25_RS19410	COG0631	protein serine/threonine phosphatase activity
EXW25_RS19420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW25_RS19420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW25_RS19425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW25_RS19435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW25_RS19440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW25_RS19460	COG1561	YicC-like family, N-terminal region
EXW25_RS19465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW25_RS19475	COG0006	proline dipeptidase activity
EXW25_RS19560	COG0564	pseudouridine synthase activity
EXW25_RS19580	COG3599	regulation of cell shape
EXW25_RS19585	COG2302	S4 RNA-binding domain
EXW25_RS19590	COG0762	integral membrane protein
EXW25_RS19600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW25_RS19610	COG1873	PFAM PRC-barrel domain
EXW25_RS19615	COG1191	sigma factor activity
EXW25_RS19620	COG1191	sigma factor activity
EXW25_RS19630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW25_RS19635	COG0849	cell division
EXW25_RS19640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW25_RS19655	COG0772	Belongs to the SEDS family
EXW25_RS19675	COG0768	penicillin binding
EXW25_RS19680	COG0768	penicillin binding
EXW25_RS19700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW25_RS19715	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW25_RS19720	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW25_RS19730	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW25_RS19735	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW25_RS19740	COG3314	Sporulation integral membrane protein YlbJ
EXW25_RS19750	COG0742	ribosomal rna small subunit methyltransferase
EXW25_RS19765	COG3679	Belongs to the UPF0342 family
EXW25_RS19770	COG0406	alpha-ribazole phosphatase activity
EXW25_RS19785	COG2340	Cysteine-rich secretory protein family
EXW25_RS19800	COG3336	cytochrome c oxidase
EXW25_RS19835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW25_RS19840	COG0772	Belongs to the SEDS family
EXW25_RS19850	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW25_RS19855	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW25_RS19865	COG4896	Protein conserved in bacteria
EXW25_RS19880	COG1217	gtp-binding protein TYPA
EXW25_RS19890	COG0483	inositol monophosphate 1-phosphatase activity
EXW25_RS19910	COG1982	Orn Lys Arg decarboxylase major
EXW25_RS19970	COG0022	dehydrogenase e1 component
EXW25_RS19975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW25_RS19985	COG0242	peptide deformylase activity
EXW25_RS19990	COG0561	phosphatase activity
EXW25_RS19995	COG5503	Protein of unknown function (DUF1447)
EXW25_RS20000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW25_RS20005	COG0569	domain protein
EXW25_RS20020	COG2171	N-acyltransferase activity
EXW25_RS20025	COG0583	DNA-binding transcription factor activity
EXW25_RS20030	COG0517	IMP dehydrogenase activity
EXW25_RS20040	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW25_RS20050	COG4703	Protein of unknown function (DUF1797)
EXW25_RS20070	COG2200	EAL domain
EXW25_RS20075	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS20080	COG1408	metallophosphoesterase
EXW25_RS20090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EXW25_RS20125	COG2814	Major facilitator Superfamily
EXW25_RS20145	COG3209	COG3209 Rhs family protein
EXW25_RS20155	COG2205	protein histidine kinase activity
EXW25_RS20165	COG0436	Aminotransferase
EXW25_RS20170	COG1609	Transcriptional regulator
EXW25_RS20175	COG3833	ABC-type maltose transport systems, permease component
EXW25_RS20180	COG1175	transmembrane transport
EXW25_RS20185	COG2182	Extracellular solute-binding protein
EXW25_RS20200	COG0366	Alpha amylase catalytic
EXW25_RS20205	COG3842	ATPase activity
EXW25_RS20245	COG0183	Belongs to the thiolase family
EXW25_RS20275	COG1695	Transcriptional regulator
EXW25_RS20280	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS20295	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW25_RS20300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW25_RS20305	COG0436	Aminotransferase
EXW25_RS20340	COG2084	Dehydrogenase
EXW25_RS20350	COG2199	diguanylate cyclase activity
EXW25_RS20355	COG0778	Nitroreductase
EXW25_RS20380	COG1263	PTS System
EXW25_RS20380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS20380	COG2190	(PTS) system
EXW25_RS20385	COG3711	transcriptional antiterminator
EXW25_RS20395	COG2188	Transcriptional regulator
EXW25_RS20405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW25_RS20430	COG1547	Domain of unknown function (DUF309)
EXW25_RS20435	COG0456	acetyltransferase
EXW25_RS20440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW25_RS20445	COG4086	secreted protein
EXW25_RS20450	COG0561	phosphatase activity
EXW25_RS20455	COG0697	spore germination
EXW25_RS20470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW25_RS20495	COG0733	neurotransmitter:sodium symporter activity
EXW25_RS20515	COG1686	Belongs to the peptidase S11 family
EXW25_RS20520	COG1725	Transcriptional regulator
EXW25_RS20525	COG1131	(ABC) transporter
EXW25_RS20545	COG1846	Transcriptional regulator
EXW25_RS20560	COG0598	Magnesium transport protein CorA
EXW25_RS20585	COG4974	Belongs to the 'phage' integrase family
EXW25_RS20595	COG0735	belongs to the Fur family
EXW25_RS20600	COG1300	Membrane
EXW25_RS20620	COG0667	Aldo Keto reductase
EXW25_RS20625	COG0656	L-ascorbic acid biosynthetic process
EXW25_RS20630	COG0456	acetyltransferase
EXW25_RS20630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW25_RS20640	COG4085	toxin activity
EXW25_RS20640	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS20640	COG1525	nuclease
EXW25_RS20650	COG0596	Alpha beta hydrolase
EXW25_RS20655	COG2056	Na+-H+ antiporter family
EXW25_RS20660	COG1609	Transcriptional regulator
EXW25_RS20665	COG0454	-acetyltransferase
EXW25_RS20670	COG1073	alpha beta
EXW25_RS20685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW25_RS20685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW25_RS20690	COG0307	riboflavin synthase, alpha
EXW25_RS20715	COG4106	trans-aconitate 2-methyltransferase activity
EXW25_RS20720	COG2226	methyltransferase
EXW25_RS20720	COG1073	alpha beta
EXW25_RS20735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW25_RS20745	COG1757	Na H antiporter
EXW25_RS20750	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS20760	COG1522	sequence-specific DNA binding
EXW25_RS20805	COG0300	oxidoreductase activity
EXW25_RS20810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS20815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW25_RS20820	COG1760	l-serine dehydratase
EXW25_RS20825	COG1760	l-serine dehydratase
EXW25_RS20845	COG1285	pathogenesis
EXW25_RS20860	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW25_RS20865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS20880	COG1376	ErfK ybiS ycfS ynhG family protein
EXW25_RS20885	COG4129	membrane
EXW25_RS20890	COG1126	abc transporter atp-binding protein
EXW25_RS20895	COG0765	amino acid transport
EXW25_RS20900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW25_RS20915	COG2816	NAD+ diphosphatase activity
EXW25_RS20920	COG2323	membrane
EXW25_RS20925	COG0772	Belongs to the SEDS family
EXW25_RS20930	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW25_RS20935	COG0022	dehydrogenase e1 component
EXW25_RS20940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW25_RS20945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW25_RS20960	COG0280	phosphate acetyltransferase
EXW25_RS20965	COG3829	transcription factor binding
EXW25_RS20965	COG3290	protein histidine kinase activity
EXW25_RS20975	COG0584	glycerophosphoryl diester phosphodiesterase
EXW25_RS20980	COG3093	addiction module antidote protein HigA
EXW25_RS20985	COG1215	transferase activity, transferring glycosyl groups
EXW25_RS21005	COG0745	RESPONSE REGULATOR receiver
EXW25_RS21010	COG0750	zinc metalloprotease
EXW25_RS21015	COG0497	DNA recombination
EXW25_RS21025	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW25_RS21035	COG0142	geranyltranstransferase activity
EXW25_RS21055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW25_RS21060	COG1302	Protein conserved in bacteria
EXW25_RS21065	COG0439	Biotin carboxylase
EXW25_RS21070	COG0511	ligase activity, forming carbon-carbon bonds
EXW25_RS21115	COG3854	ATPases associated with a variety of cellular activities
EXW25_RS21140	COG0006	proline dipeptidase activity
EXW25_RS21155	COG3872	metal-dependent enzyme
EXW25_RS21165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW25_RS21195	COG0095	Lipoate-protein ligase
EXW25_RS21200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS21210	COG1609	Transcriptional regulator
EXW25_RS21220	COG2076	Multidrug Resistance protein
EXW25_RS21225	COG2076	Multidrug Resistance protein
EXW25_RS21260	COG1725	Transcriptional regulator
EXW25_RS21275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW25_RS21285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW25_RS21290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW25_RS21330	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW25_RS21360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW25_RS21365	COG2169	Transcriptional regulator
EXW25_RS21400	COG4970	Tfp pilus assembly protein FimT
EXW25_RS21410	COG1459	type II secretion system
EXW25_RS21415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW25_RS21470	COG0646	methionine synthase
EXW25_RS21470	COG1410	methionine synthase
EXW25_RS21475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW25_RS21475	COG0646	methionine synthase
EXW25_RS21480	COG0626	cystathionine gamma-synthase activity
EXW25_RS21485	COG0626	cystathionine gamma-synthase activity
EXW25_RS21510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS21520	COG1940	carbohydrate kinase activity
EXW25_RS21525	COG4483	Protein conserved in bacteria
EXW25_RS21530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW25_RS21535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW25_RS21540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW25_RS21545	COG0704	Plays a role in the regulation of phosphate uptake
EXW25_RS21555	COG0581	inorganic phosphate transmembrane transporter activity
EXW25_RS21560	COG0573	inorganic phosphate transmembrane transporter activity
EXW25_RS21565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW25_RS21570	COG0768	penicillin binding
EXW25_RS21575	COG0477	Major facilitator Superfamily
EXW25_RS21580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW25_RS21605	COG0735	belongs to the Fur family
EXW25_RS21610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW25_RS21615	COG1121	(ABC) transporter
EXW25_RS21620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS21650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW25_RS21655	COG2384	SAM-dependent methyltransferase
EXW25_RS21660	COG2010	Cytochrome c
EXW25_RS21665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW25_RS21670	COG0358	DNA primase activity
EXW25_RS21675	COG1671	Belongs to the UPF0178 family
EXW25_RS21685	COG0517	IMP dehydrogenase activity
EXW25_RS21700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW25_RS21705	COG0295	cytidine deaminase activity
EXW25_RS21710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW25_RS21715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW25_RS21720	COG1480	7TM receptor with intracellular HD hydrolase
EXW25_RS21725	COG1702	phosphate starvation-inducible protein PhoH
EXW25_RS21740	COG1610	YqeY-like protein
EXW25_RS21745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW25_RS21750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW25_RS21755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW25_RS21765	COG0484	heat shock protein binding
EXW25_RS21780	COG1420	regulation of RNA biosynthetic process
EXW25_RS21785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW25_RS21790	COG1733	regulation of RNA biosynthetic process
EXW25_RS21815	COG1466	dna polymerase III delta subunit
EXW25_RS21825	COG2333	competence protein COMEC
EXW25_RS21825	COG0658	competence protein
EXW25_RS21830	COG2131	deaminase
EXW25_RS21835	COG1555	photosystem II stabilization
EXW25_RS21835	COG1596	polysaccharide export
EXW25_RS21840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW25_RS21845	COG2226	methyltransferase
EXW25_RS21850	COG0799	negative regulation of ribosome biogenesis
EXW25_RS21855	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW25_RS21860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW25_RS21865	COG1534	Rna-binding protein
EXW25_RS21875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW25_RS21880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW25_RS21915	COG0778	Nitroreductase
EXW25_RS21920	COG2357	RelA SpoT domain protein
EXW25_RS21930	COG1785	Belongs to the alkaline phosphatase family
EXW25_RS21940	COG2267	carboxylic ester hydrolase activity
EXW25_RS21975	COG1404	Belongs to the peptidase S8 family
EXW25_RS21980	COG3186	Phenylalanine-4-hydroxylase
EXW25_RS21990	COG2514	catechol 2,3-dioxygenase activity
EXW25_RS21995	COG2259	Doxx family
EXW25_RS22035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS22045	COG1454	alcohol dehydrogenase
EXW25_RS22045	COG1012	belongs to the aldehyde dehydrogenase family
EXW25_RS22050	COG0626	cystathionine gamma-synthase activity
EXW25_RS22055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW25_RS22080	COG0768	penicillin binding
EXW25_RS22095	COG0826	peptidase U32
EXW25_RS22100	COG0826	peptidase U32
EXW25_RS22105	COG4122	O-methyltransferase activity
EXW25_RS22110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW25_RS22125	COG4472	Bacterial protein of unknown function (DUF965)
EXW25_RS22140	COG0628	permease
EXW25_RS22160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW25_RS22175	COG1104	cysteine desulfurase activity
EXW25_RS22180	COG1959	2 iron, 2 sulfur cluster binding
EXW25_RS22185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW25_RS22195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW25_RS22230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW25_RS22240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW25_RS22240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW25_RS22245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW25_RS22250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW25_RS22250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW25_RS22260	COG2244	polysaccharide biosynthetic process
EXW25_RS22265	COG2323	membrane
EXW25_RS22275	COG1862	Preprotein translocase
EXW25_RS22280	COG0343	queuine tRNA-ribosyltransferase activity
EXW25_RS22295	COG2255	four-way junction helicase activity
EXW25_RS22300	COG0632	four-way junction helicase activity
EXW25_RS22305	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW25_RS22335	COG0157	Belongs to the NadC ModD family
EXW25_RS22340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW25_RS22345	COG1104	cysteine desulfurase activity
EXW25_RS22350	COG1827	regulation of RNA biosynthetic process
EXW25_RS22355	COG2258	MOSC domain
EXW25_RS22360	COG0077	Prephenate dehydratase
EXW25_RS22365	COG0577	efflux transmembrane transporter activity
EXW25_RS22370	COG0577	efflux transmembrane transporter activity
EXW25_RS22375	COG1136	(ABC) transporter
EXW25_RS22380	COG5002	protein histidine kinase activity
EXW25_RS22385	COG0745	RESPONSE REGULATOR receiver
EXW25_RS22395	COG3290	protein histidine kinase activity
EXW25_RS22405	COG2868	ribosomal protein
EXW25_RS22415	COG1530	ribonuclease E activity
EXW25_RS22420	COG1994	Peptidase M50
EXW25_RS22425	COG0739	heme binding
EXW25_RS22430	COG2894	cell division
EXW25_RS22450	COG1077	Cell shape determining protein MreB Mrl
EXW25_RS22470	COG0285	dihydrofolate synthase activity
EXW25_RS22485	COG1388	LysM domain
EXW25_RS22495	COG0113	porphobilinogen synthase activity
EXW25_RS22500	COG1587	Uroporphyrinogen-III synthase
EXW25_RS22510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW25_RS22520	COG1846	Transcriptional regulator
EXW25_RS22525	COG1764	response to oxidative stress
EXW25_RS22540	COG0470	DNA polymerase III
EXW25_RS22540	COG1067	ATP-dependent peptidase activity
EXW25_RS22585	COG0622	Phosphoesterase
EXW25_RS22600	COG5401	PFAM Sporulation and spore germination
EXW25_RS22615	COG2197	response regulator
EXW25_RS22620	COG2233	PERMEase
EXW25_RS22625	COG0402	S-adenosylhomocysteine deaminase activity
EXW25_RS22630	COG1983	PspC domain protein
EXW25_RS22635	COG1396	sequence-specific DNA binding
EXW25_RS22640	COG0697	spore germination
EXW25_RS22650	COG1959	2 iron, 2 sulfur cluster binding
EXW25_RS22655	COG1668	transmembrane transport
EXW25_RS22660	COG4152	abc transporter atp-binding protein
EXW25_RS22665	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW25_RS22670	COG1360	Flagellar Motor Protein
EXW25_RS22675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW25_RS22680	COG1876	peptidase activity
EXW25_RS22685	COG0824	Thioesterase
EXW25_RS22690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW25_RS22695	COG1053	succinate dehydrogenase
EXW25_RS22700	COG2009	succinate dehydrogenase
EXW25_RS22705	COG1719	4-vinyl reductase, 4VR
EXW25_RS22710	COG0322	excinuclease ABC activity
EXW25_RS22715	COG3118	belongs to the thioredoxin family
EXW25_RS22720	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW25_RS22725	COG2086	electron transfer activity
EXW25_RS22730	COG1024	Enoyl-CoA hydratase
EXW25_RS22735	COG1309	transcriptional regulator
EXW25_RS22740	COG0318	PFAM AMP-dependent synthetase and ligase
EXW25_RS22765	COG2318	DinB family
EXW25_RS22795	COG1131	(ABC) transporter
EXW25_RS22800	COG2205	protein histidine kinase activity
EXW25_RS22805	COG0745	RESPONSE REGULATOR receiver
EXW25_RS22815	COG4895	conserved protein (DUF2196)
EXW25_RS22820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW25_RS22830	COG4509	Sortase family
EXW25_RS22835	COG1120	ATPase activity
EXW25_RS22850	COG5386	Cell surface protein
EXW25_RS22860	COG5386	Cell surface protein
EXW25_RS22865	COG1114	Component of the transport system for branched-chain amino acids
EXW25_RS22870	COG1187	pseudouridine synthase activity
EXW25_RS22880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW25_RS22880	COG1796	DNA polymerase
EXW25_RS22885	COG1286	toxin biosynthetic process
EXW25_RS22890	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW25_RS22925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW25_RS22935	COG1418	mRNA catabolic process
EXW25_RS22955	COG2814	Major facilitator Superfamily
EXW25_RS22960	COG1566	PFAM secretion protein HlyD family protein
EXW25_RS22965	COG1309	transcriptional regulator
EXW25_RS22970	COG1363	Peptidase, m42
EXW25_RS22995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW25_RS23005	COG1484	DNA-dependent DNA replication
EXW25_RS23010	COG3611	Membrane attachment protein
EXW25_RS23020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW25_RS23025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW25_RS23030	COG0237	dephospho-CoA kinase activity
EXW25_RS23035	COG1971	Probably functions as a manganese efflux pump
EXW25_RS23045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW25_RS23045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW25_RS23050	COG5002	protein histidine kinase activity
EXW25_RS23055	COG0745	RESPONSE REGULATOR receiver
EXW25_RS23075	COG0538	isocitrate dehydrogenase activity
EXW25_RS23080	COG0372	Belongs to the citrate synthase family
EXW25_RS23090	COG0628	permease
EXW25_RS23095	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW25_RS23120	COG1725	Transcriptional regulator
EXW25_RS23125	COG0281	malic enzyme
EXW25_RS23130	COG0587	DNA-directed DNA polymerase activity
EXW25_RS23145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW25_RS23160	COG4109	DRTGG domain
EXW25_RS23175	COG0006	proline dipeptidase activity
EXW25_RS23215	COG0662	Cupin 2, conserved barrel domain protein
EXW25_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
EXW25_RS23235	COG0589	response to stress
EXW25_RS23240	COG0346	lactoylglutathione lyase activity
EXW25_RS23280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS23305	COG0827	DNA restriction-modification system
EXW25_RS23310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW25_RS23315	COG3874	Sporulation protein YtfJ
EXW25_RS23330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW25_RS23340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW25_RS23355	COG1104	cysteine desulfurase activity
EXW25_RS23360	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW25_RS23365	COG0583	DNA-binding transcription factor activity
EXW25_RS23370	COG0697	spore germination
EXW25_RS23375	COG1309	transcriptional regulator
EXW25_RS23380	COG1956	GAF domain-containing protein
EXW25_RS23385	COG0626	cystathionine gamma-synthase activity
EXW25_RS23420	COG1595	DNA-templated transcription, initiation
EXW25_RS23430	COG0110	maltose O-acetyltransferase activity
EXW25_RS23435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW25_RS23440	COG0454	-acetyltransferase
EXW25_RS23445	COG0517	IMP dehydrogenase activity
EXW25_RS23450	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW25_RS23465	COG0745	RESPONSE REGULATOR receiver
EXW25_RS23470	COG5002	protein histidine kinase activity
EXW25_RS23475	COG0666	response to abiotic stimulus
EXW25_RS23505	COG1609	Transcriptional regulator
EXW25_RS23515	COG4851	CamS sex pheromone cAM373 precursor
EXW25_RS23520	COG3118	belongs to the thioredoxin family
EXW25_RS23530	COG2309	aminopeptidase activity
EXW25_RS23575	COG1674	ftsk spoiiie
EXW25_RS23580	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS23580	COG1388	LysM domain
EXW25_RS23590	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW25_RS23595	COG4848	Belongs to the UPF0354 family
EXW25_RS23600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW25_RS23605	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW25_RS23610	COG1363	Peptidase, m42
EXW25_RS23620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS23635	COG0510	thiamine kinase activity
EXW25_RS23640	COG1523	belongs to the glycosyl hydrolase 13 family
EXW25_RS23650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW25_RS23655	COG1349	DNA-binding transcription factor activity
EXW25_RS23660	COG1187	pseudouridine synthase activity
EXW25_RS23665	COG2244	polysaccharide biosynthetic process
EXW25_RS23670	COG2081	HI0933 family
EXW25_RS23675	COG2814	Major facilitator Superfamily
EXW25_RS23685	COG3832	glyoxalase III activity
EXW25_RS23715	COG1329	Transcriptional regulator
EXW25_RS23740	COG0314	molybdopterin synthase activity
EXW25_RS23745	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW25_RS23750	COG0303	'Molybdopterin
EXW25_RS23760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW25_RS23765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW25_RS23785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW25_RS23795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW25_RS23840	COG2814	Major facilitator Superfamily
EXW25_RS23845	COG0475	glutathione-regulated potassium exporter activity
EXW25_RS23850	COG0490	domain, Protein
EXW25_RS23855	COG0582	viral genome integration into host DNA
EXW25_RS23870	COG1136	(ABC) transporter
EXW25_RS23890	COG1242	4 iron, 4 sulfur cluster binding
EXW25_RS23895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW25_RS23900	COG1794	racemase activity, acting on amino acids and derivatives
EXW25_RS23915	COG2267	carboxylic ester hydrolase activity
EXW25_RS23920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW25_RS23925	COG0671	phosphoesterase, PA-phosphatase related
EXW25_RS23930	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS23990	COG3852	Histidine kinase
EXW25_RS23995	COG3852	Histidine kinase
EXW25_RS24005	COG2267	carboxylic ester hydrolase activity
EXW25_RS24010	COG1368	sulfuric ester hydrolase activity
EXW25_RS24025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW25_RS24030	COG1116	anion transmembrane transporter activity
EXW25_RS24035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW25_RS24060	COG0494	nUDIX hydrolase
EXW25_RS24090	COG2076	Multidrug Resistance protein
EXW25_RS24095	COG2076	Multidrug Resistance protein
EXW25_RS24100	COG0789	Transcriptional regulator
EXW25_RS24105	COG1854	S-ribosylhomocysteine lyase activity
EXW25_RS24115	COG0288	reversible hydration of carbon dioxide
EXW25_RS24120	COG1271	oxidase subunit
EXW25_RS24125	COG1294	oxidase, subunit
EXW25_RS24140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS24165	COG1842	Phage shock protein A
EXW25_RS24195	COG5002	protein histidine kinase activity
EXW25_RS24200	COG0745	RESPONSE REGULATOR receiver
EXW25_RS24225	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW25_RS24230	COG1597	lipid kinase activity
EXW25_RS24240	COG0577	efflux transmembrane transporter activity
EXW25_RS24245	COG1136	(ABC) transporter
EXW25_RS24260	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS24265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW25_RS24270	COG0577	efflux transmembrane transporter activity
EXW25_RS24275	COG1136	(ABC) transporter
EXW25_RS24280	COG2207	Transcriptional regulator
EXW25_RS24280	COG3708	Transcriptional regulator
EXW25_RS24290	COG1131	(ABC) transporter
EXW25_RS24295	COG5658	integral membrane protein
EXW25_RS24300	COG0640	Transcriptional regulator
EXW25_RS24310	COG1595	DNA-templated transcription, initiation
EXW25_RS24315	COG0745	RESPONSE REGULATOR receiver
EXW25_RS24320	COG2205	protein histidine kinase activity
EXW25_RS24325	COG0577	efflux transmembrane transporter activity
EXW25_RS24330	COG0577	efflux transmembrane transporter activity
EXW25_RS24335	COG1136	(ABC) transporter
EXW25_RS24340	COG0577	efflux transmembrane transporter activity
EXW25_RS24365	COG2188	Transcriptional regulator
EXW25_RS24385	COG3964	amidohydrolase
EXW25_RS24400	COG0745	RESPONSE REGULATOR receiver
EXW25_RS24405	COG4948	Mandelate Racemase Muconate Lactonizing
EXW25_RS24415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW25_RS24420	COG0596	Alpha beta hydrolase
EXW25_RS24430	COG1169	isochorismate synthase
EXW25_RS24435	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW25_RS24440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW25_RS24445	COG1278	Cold shock
EXW25_RS24465	COG0058	SHG alpha-glucan phosphorylase activity
EXW25_RS24475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW25_RS24480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW25_RS24635	COG1285	pathogenesis
EXW25_RS24640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW25_RS24655	COG2155	Conserved Protein
EXW25_RS24660	COG1098	S1 RNA binding domain
EXW25_RS24665	COG0436	Aminotransferase
EXW25_RS24670	COG1522	sequence-specific DNA binding
EXW25_RS24675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW25_RS24680	COG2267	carboxylic ester hydrolase activity
EXW25_RS24690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW25_RS24710	COG5018	Exonuclease
EXW25_RS24715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW25_RS24735	COG2050	protein possibly involved in aromatic compounds catabolism
EXW25_RS24745	COG1268	BioY protein
EXW25_RS24750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW25_RS24755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW25_RS24775	COG3584	3D domain protein
EXW25_RS24790	COG1252	NADH dehydrogenase
EXW25_RS24800	COG3708	Transcriptional regulator
EXW25_RS24815	COG1683	Conserved Protein
EXW25_RS24835	COG0316	Belongs to the HesB IscA family
EXW25_RS24850	COG1252	NADH dehydrogenase
EXW25_RS24860	COG2274	protein secretion by the type I secretion system
EXW25_RS24865	COG0390	transport system, permease component
EXW25_RS24870	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW25_RS24900	COG4837	Protein of unknown function (DUF1462)
EXW25_RS24905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW25_RS24915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW25_RS24920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW25_RS24940	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW25_RS24950	COG0647	UMP catabolic process
EXW25_RS24960	COG2445	Protein of unknown function DUF86
EXW25_RS24965	COG1494	fructose-1,6-bisphosphatase
EXW25_RS24985	COG4470	Protein conserved in bacteria
EXW25_RS24995	COG0789	Transcriptional regulator
EXW25_RS25000	COG4377	Putative membrane peptidase family (DUF2324)
EXW25_RS25025	COG0739	heme binding
EXW25_RS25035	COG3377	Domain of unknown function (DUF1805)
EXW25_RS25040	COG0737	Belongs to the 5'-nucleotidase family
EXW25_RS25045	COG0719	Fe-S assembly protein
EXW25_RS25050	COG0822	iron-sulfur transferase activity
EXW25_RS25055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW25_RS25060	COG0719	Fe-S assembly protein
EXW25_RS25065	COG0396	ATPase activity
EXW25_RS25070	COG1464	Belongs to the NlpA lipoprotein family
EXW25_RS25075	COG1464	Belongs to the NlpA lipoprotein family
EXW25_RS25080	COG2011	ABC-type metal ion transport system permease component
EXW25_RS25095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW25_RS25100	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW25_RS25115	COG1393	Belongs to the ArsC family
EXW25_RS25145	COG0039	L-malate dehydrogenase activity
EXW25_RS25170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS25175	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS25180	COG0183	Belongs to the thiolase family
EXW25_RS25185	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW25_RS25185	COG1024	Enoyl-CoA hydratase
EXW25_RS25195	COG1686	Belongs to the peptidase S11 family
EXW25_RS25200	COG0506	proline dehydrogenase activity
EXW25_RS25210	COG0011	TIGRFAM Protein of
EXW25_RS25215	COG0840	transmembrane signaling receptor activity
EXW25_RS25230	COG2814	Major facilitator Superfamily
EXW25_RS25235	COG0531	amino acid
EXW25_RS25260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW25_RS25295	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS25305	COG1376	ErfK ybiS ycfS ynhG family protein
EXW25_RS25310	COG0745	RESPONSE REGULATOR receiver
EXW25_RS25315	COG5002	protein histidine kinase activity
EXW25_RS25325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW25_RS25340	COG0840	transmembrane signaling receptor activity
EXW25_RS25345	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW25_RS25350	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS25370	COG0586	Pfam SNARE associated Golgi protein
EXW25_RS25375	COG0475	glutathione-regulated potassium exporter activity
EXW25_RS25380	COG0490	domain, Protein
EXW25_RS25385	COG1115	amino acid carrier protein
EXW25_RS25390	COG0783	Belongs to the Dps family
EXW25_RS25405	COG1611	Belongs to the LOG family
EXW25_RS25415	COG1528	Iron-storage protein
EXW25_RS25420	COG2311	Membrane
EXW25_RS25425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS25430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS25435	COG1115	amino acid carrier protein
EXW25_RS25440	COG1115	amino acid carrier protein
EXW25_RS25445	COG2910	NAD(P)H-binding
EXW25_RS25460	COG0656	L-ascorbic acid biosynthetic process
EXW25_RS25465	COG2814	Major facilitator Superfamily
EXW25_RS25470	COG1733	regulation of RNA biosynthetic process
EXW25_RS25480	COG1252	NADH dehydrogenase
EXW25_RS25485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EXW25_RS25500	COG3290	protein histidine kinase activity
EXW25_RS25500	COG0840	transmembrane signaling receptor activity
EXW25_RS25510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW25_RS25535	COG0488	(ABC) transporter
EXW25_RS25540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS25555	COG1335	isochorismatase
EXW25_RS25560	COG1522	sequence-specific DNA binding
EXW25_RS25615	COG0557	exoribonuclease II activity
EXW25_RS25620	COG1647	Serine aminopeptidase, S33
EXW25_RS25625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW25_RS25630	COG1346	cytolysis
EXW25_RS25665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW25_RS25680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW25_RS25715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW25_RS25730	COG2323	membrane
EXW25_RS25740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW25_RS25750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW25_RS25760	COG1051	belongs to the nudix hydrolase family
EXW25_RS25770	COG0492	ferredoxin-NADP+ reductase activity
EXW25_RS25775	COG0457	Tetratricopeptide repeat
EXW25_RS25780	COG0110	maltose O-acetyltransferase activity
EXW25_RS25800	COG1950	PFAM Membrane protein of
EXW25_RS25810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW25_RS25815	COG0556	nucleotide-excision repair
EXW25_RS25830	COG0789	Transcriptional regulator
EXW25_RS25860	COG0583	DNA-binding transcription factor activity
EXW25_RS25870	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW25_RS25875	COG0488	(ABC) transporter
EXW25_RS25885	COG1132	(ABC) transporter
EXW25_RS25890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW25_RS25895	COG3409	Peptidoglycan-binding domain 1 protein
EXW25_RS25895	COG0793	Belongs to the peptidase S41A family
EXW25_RS25900	COG2177	Part of the ABC transporter FtsEX involved in
EXW25_RS25905	COG2884	Cell division ATP-binding protein ftsE
EXW25_RS25925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EXW25_RS25930	COG1278	Cold shock
EXW25_RS25935	COG1040	competence protein
EXW25_RS25970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW25_RS25985	COG1388	LysM domain
EXW25_RS25985	COG0791	NLP P60 protein
EXW25_RS25990	COG1733	regulation of RNA biosynthetic process
EXW25_RS25995	COG1307	EDD domain protein, DegV family
EXW25_RS26000	COG1739	Uncharacterized protein family UPF0029
EXW25_RS26005	COG1316	TRANSCRIPTIONal
EXW25_RS26010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW25_RS26015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW25_RS26020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW25_RS26030	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW25_RS26030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW25_RS26050	COG1486	melibiose metabolic process
EXW25_RS26055	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW25_RS26060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW25_RS26080	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW25_RS26090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW25_RS26095	COG1301	dicarboxylic acid transport
EXW25_RS26105	COG0346	lactoylglutathione lyase activity
EXW25_RS26110	COG1511	domain protein
EXW25_RS26115	COG0583	DNA-binding transcription factor activity
EXW25_RS26120	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW25_RS26130	COG1271	oxidase subunit
EXW25_RS26135	COG1294	oxidase, subunit
EXW25_RS26140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW25_RS26150	COG1620	l-lactate permease
EXW25_RS26160	COG2389	metal-binding protein
EXW25_RS26170	COG1368	sulfuric ester hydrolase activity
EXW25_RS26180	COG0791	NLP P60 protein
EXW25_RS26180	COG1388	LysM domain
EXW25_RS26185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW25_RS26195	COG1215	transferase activity, transferring glycosyl groups
EXW25_RS26200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW25_RS26205	COG1388	LysM domain
EXW25_RS26205	COG3584	3D domain protein
EXW25_RS26215	COG4715	Zinc finger, swim domain protein
EXW25_RS26220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW25_RS26260	COG0577	efflux transmembrane transporter activity
EXW25_RS26265	COG1136	(ABC) transporter
EXW25_RS26290	COG5002	protein histidine kinase activity
EXW25_RS26290	COG3850	Histidine kinase
EXW25_RS26295	COG0745	RESPONSE REGULATOR receiver
EXW25_RS26300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW25_RS26305	COG4750	Nucleotidyl transferase
EXW25_RS26310	COG0697	spore germination
EXW25_RS26320	COG3475	LICD family
EXW25_RS26330	COG1316	TRANSCRIPTIONal
EXW25_RS26335	COG0562	UDP-galactopyranose mutase
EXW25_RS26350	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS26370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW25_RS26385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW25_RS26390	COG1086	Polysaccharide biosynthesis protein
EXW25_RS26395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW25_RS26400	COG4464	protein tyrosine phosphatase activity
EXW25_RS26405	COG0489	protein tyrosine kinase activity
EXW25_RS26410	COG3944	biosynthesis protein
EXW25_RS26415	COG0489	protein tyrosine kinase activity
EXW25_RS26430	COG1609	Transcriptional regulator
EXW25_RS26440	COG0739	heme binding
EXW25_RS26455	COG3279	Response regulator of the LytR AlgR family
EXW25_RS26460	COG2385	sporulation resulting in formation of a cellular spore
EXW25_RS26475	COG4836	Membrane
EXW25_RS26480	COG1007	ATP synthesis coupled electron transport
EXW25_RS26485	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW25_RS26490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW25_RS26500	COG0839	Belongs to the complex I subunit 6 family
EXW25_RS26520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW25_RS26565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW25_RS26585	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW25_RS26620	COG0698	ribose 5-phosphate isomerase
EXW25_RS26630	COG2190	(PTS) system
EXW25_RS26635	COG2259	Doxx family
EXW25_RS26640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW25_RS26655	COG0009	L-threonylcarbamoyladenylate synthase
EXW25_RS26675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW25_RS26690	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW25_RS26695	COG1494	fructose-1,6-bisphosphatase
EXW25_RS26715	COG4821	SIS domain
EXW25_RS26720	COG0504	CTP synthase activity
EXW25_RS26735	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS26740	COG1960	acyl-CoA dehydrogenase activity
EXW25_RS26745	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW25_RS26755	COG0247	lactate metabolic process
EXW25_RS26755	COG2181	nitrate reductase activity
EXW25_RS26760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW25_RS26770	COG3300	MHYT domain
EXW25_RS26770	COG5001	Diguanylate cyclase
EXW25_RS26785	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS26790	COG2197	response regulator
EXW25_RS26795	COG4585	Histidine kinase
EXW25_RS26800	COG0842	Transport permease protein
EXW25_RS26805	COG1131	(ABC) transporter
EXW25_RS26810	COG0024	Methionine aminopeptidase
EXW25_RS26820	COG2234	aminopeptidase activity
EXW25_RS26840	COG4506	Protein conserved in bacteria
EXW25_RS26845	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW25_RS26865	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW25_RS26870	COG2814	Major facilitator Superfamily
EXW25_RS26875	COG0789	Transcriptional regulator
EXW25_RS26880	COG0584	glycerophosphoryl diester phosphodiesterase
EXW25_RS26885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS26895	COG1994	Peptidase M50
EXW25_RS26905	COG1078	dGTPase activity
EXW25_RS26910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW25_RS26915	COG1120	ATPase activity
EXW25_RS26920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS26925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW25_RS26930	COG4844	belongs to the
EXW25_RS26945	COG0280	phosphate acetyltransferase
EXW25_RS26960	COG3773	Cell wall hydrolase
EXW25_RS26970	COG2363	Small membrane protein
EXW25_RS26980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW25_RS26985	COG2233	PERMEase
EXW25_RS26990	COG0561	phosphatase activity
EXW25_RS26995	COG2814	Major facilitator Superfamily
EXW25_RS27005	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW25_RS27010	COG1131	(ABC) transporter
EXW25_RS27015	COG2755	lipolytic protein G-D-S-L family
EXW25_RS27020	COG1609	Transcriptional regulator
EXW25_RS27030	COG0460	homoserine dehydrogenase
EXW25_RS27040	COG2873	o-acetylhomoserine
EXW25_RS27050	COG1011	Hydrolase
EXW25_RS27055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW25_RS27065	COG2197	response regulator
EXW25_RS27070	COG4585	Histidine kinase
EXW25_RS27070	COG2203	Gaf domain
EXW25_RS27075	COG0351	phosphomethylpyrimidine kinase
EXW25_RS27080	COG3706	GGDEF domain
EXW25_RS27085	COG2879	small protein
EXW25_RS27090	COG1966	Carbon starvation protein
EXW25_RS27095	COG3279	Response regulator of the LytR AlgR family
EXW25_RS27100	COG0477	Major facilitator Superfamily
EXW25_RS27110	COG0438	transferase activity, transferring glycosyl groups
EXW25_RS27125	COG0840	transmembrane signaling receptor activity
EXW25_RS27135	COG1607	acyl-coa hydrolase
EXW25_RS27145	COG1215	transferase activity, transferring glycosyl groups
EXW25_RS27155	COG1309	transcriptional regulator
EXW25_RS27160	COG0488	(ABC) transporter
EXW25_RS27180	COG0463	Glycosyl transferase, family 2
EXW25_RS27185	COG1309	transcriptional regulator
EXW25_RS27190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW25_RS27195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW25_RS27195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW25_RS27200	COG0628	permease
EXW25_RS27220	COG3275	phosphorelay sensor kinase activity
EXW25_RS27225	COG2814	Major facilitator Superfamily
EXW25_RS27230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW25_RS27235	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW25_RS27240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW25_RS27260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW25_RS27265	COG1272	protein, Hemolysin III
EXW25_RS27290	COG1164	Oligoendopeptidase f
EXW25_RS27310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW25_RS27315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW25_RS27320	COG4853	Protein conserved in bacteria
EXW25_RS27330	COG5002	protein histidine kinase activity
EXW25_RS27335	COG0745	RESPONSE REGULATOR receiver
EXW25_RS27365	COG0305	Participates in initiation and elongation during chromosome replication
EXW25_RS27375	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW25_RS27380	COG4241	membrane
EXW25_RS27390	COG0629	single-stranded DNA binding
EXW25_RS27400	COG0012	GTP binding
EXW25_RS27405	COG4481	Protein conserved in bacteria
EXW25_RS27410	COG0668	transmembrane transport
EXW25_RS27420	COG1475	DNA binding
EXW25_RS27425	COG1192	Involved in chromosome partitioning
EXW25_RS27450	COG1847	R3H domain protein
EXW25_RS27455	COG0706	membrane insertase activity
EXW25_RS27465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW25_RS27565	COG1923	regulation of RNA biosynthetic process
EXW25_RS27590	COG2002	toxin-antitoxin pair type II binding
EXW25_RS27600	COG1923	regulation of RNA biosynthetic process
EXW25_RS27620	COG1476	TRANSCRIPTIONal
EXW25_RS27640	COG2409	Drug exporters of the RND superfamily
EXW25_RS27680	COG2312	Erythromycin esterase
EXW25_RS27710	COG0582	viral genome integration into host DNA
EXW25_RS27800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW25_RS27835	COG1136	(ABC) transporter
EXW25_RS27840	COG0577	efflux transmembrane transporter activity
EXW25_RS27850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS27860	COG3829	transcription factor binding
EXW25_RS27860	COG3290	protein histidine kinase activity
EXW25_RS27865	COG1288	antiporter activity
EXW25_RS27885	COG0697	spore germination
EXW25_RS27910	COG1329	Transcriptional regulator
EXW25_RS27935	COG1999	signal sequence binding
EXW25_RS27940	COG0662	Cupin 2, conserved barrel domain protein
EXW25_RS27950	COG0010	Belongs to the arginase family
EXW25_RS27960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW25_RS27975	COG0456	acetyltransferase
EXW25_RS28000	COG5183	chlorophyll binding
EXW25_RS28000	COG2133	pyrroloquinoline quinone binding
EXW25_RS28015	COG3290	protein histidine kinase activity
EXW25_RS28020	COG4565	transcriptional regulatory protein
EXW25_RS28030	COG0753	catalase activity
EXW25_RS28140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW25_RS28150	COG2707	UPF0756 membrane protein
EXW25_RS28160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW25_RS28175	COG4974	Belongs to the 'phage' integrase family
EXW25_RS28185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW25_RS28190	COG1621	beta-fructofuranosidase activity
EXW25_RS28195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW25_RS28195	COG1263	PTS System
EXW25_RS28200	COG1609	Transcriptional regulator
EXW25_RS28225	COG5002	protein histidine kinase activity
EXW25_RS28255	COG5002	protein histidine kinase activity
EXW25_RS28280	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW25_RS28295	COG5002	protein histidine kinase activity
EXW25_RS28300	COG3842	ATPase activity
EXW25_RS28320	COG0395	ABC-type sugar transport system, permease component
EXW25_RS28325	COG1175	transmembrane transport
EXW25_RS28340	COG0745	RESPONSE REGULATOR receiver
EXW25_RS28355	COG1696	Membrane protein involved in D-alanine export
EXW25_RS28370	COG1278	Cold shock
EXW25_RS28375	COG1285	pathogenesis
EXW25_RS28380	COG0833	amino acid
EXW25_RS28400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW25_RS28520	COG3883	PFAM NLP P60 protein
EXW25_RS28520	COG0791	NLP P60 protein
EXW25_RS28700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EXW25_RS28740	COG0741	lytic transglycosylase activity
EXW25_RS28740	COG0791	NLP P60 protein
EXW25_RS28760	COG5504	Zn-dependent protease
EXW25_RS28765	COG0789	Transcriptional regulator
EXW25_RS28770	COG0789	Transcriptional regulator
EXW25_RS28855	COG1136	(ABC) transporter
EXW25_RS28860	COG0577	efflux transmembrane transporter activity
EXW25_RS28865	COG1136	(ABC) transporter
EXW25_RS28870	COG0577	efflux transmembrane transporter activity
EXW25_RS28910	COG3409	Peptidoglycan-binding domain 1 protein
EXW25_RS28910	COG3773	Cell wall hydrolase
EXW25_RS28935	COG0741	lytic transglycosylase activity
EXW25_RS28940	COG5002	protein histidine kinase activity
EXW25_RS28945	COG0745	RESPONSE REGULATOR receiver
EXW25_RS28955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW25_RS28960	COG0577	efflux transmembrane transporter activity
EXW25_RS28965	COG1136	(ABC) transporter
EXW25_RS28970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW25_RS28990	COG1404	Belongs to the peptidase S8 family
EXW25_RS29040	COG1309	transcriptional regulator
EXW25_RS29045	COG2814	Major facilitator Superfamily
EXW25_RS29055	COG0657	acetylesterase activity
EXW25_RS29065	COG0457	Tetratricopeptide repeat
EXW25_RS29115	COG3173	Aminoglycoside phosphotransferase
EXW25_RS29120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EXW25_RS29135	COG1309	transcriptional regulator
EXW25_RS29150	COG2081	HI0933 family
EXW25_RS29165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW25_RS29235	COG1162	GTPase activity
EXW25_RS29265	COG0191	fructose-bisphosphate aldolase activity
EXW25_RS29270	COG3718	enzyme involved in inositol metabolism
EXW25_RS29275	COG0772	Belongs to the SEDS family
EXW25_RS29290	COG0457	Tetratricopeptide repeat
EXW25_RS29330	COG2814	Major facilitator Superfamily
EXW25_RS29340	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EXW25_RS29360	COG0745	RESPONSE REGULATOR receiver
EXW25_RS29365	COG2205	protein histidine kinase activity
EXW25_RS29405	COG1404	Belongs to the peptidase S8 family
EXW25_RS29440	COG0697	spore germination
EXW25_RS29450	COG3397	chitin binding
EXW25_RS29465	COG0463	Glycosyl transferase, family 2
EXW25_RS29470	COG0463	Glycosyl transferase, family 2
EXW25_RS29475	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW25_RS29485	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW25_RS29490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW25_RS29495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW25_RS29510	COG2089	acid synthase
EXW25_RS29515	COG4641	Protein conserved in bacteria
EXW25_RS29530	COG1252	NADH dehydrogenase
EXW25_RS29545	COG1183	phosphatidylcholine synthase activity
EXW25_RS29555	COG1073	alpha beta
EXW25_RS29565	COG1733	regulation of RNA biosynthetic process
EXW25_RS29585	COG1876	peptidase activity
EXW25_RS29590	COG4974	Belongs to the 'phage' integrase family
EXW25_RS29605	COG1686	Belongs to the peptidase S11 family
EXW25_RS29610	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW25_RS29615	COG0583	DNA-binding transcription factor activity
EXW25_RS29625	COG0367	asparagine synthase
EXW25_RS29660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW25_RS29685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW25_RS29705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW25_RS29710	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW25_RS29730	COG5444	nuclease activity
EXW25_RS29750	COG2732	(Barnase) inhibitor
EXW25_RS29765	COG1073	alpha beta
EXW25_RS29795	COG2184	nucleotidyltransferase activity
EXW25_RS29865	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW25_RS29865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW25_RS29870	COG2205	protein histidine kinase activity
EXW25_RS29875	COG0745	RESPONSE REGULATOR receiver
EXW25_RS29880	COG0577	efflux transmembrane transporter activity
EXW25_RS29885	COG1136	(ABC) transporter
EXW25_RS29900	COG2312	Erythromycin esterase
EXW25_RS29910	COG1136	(ABC) transporter
EXW25_RS29960	COG2814	Major facilitator Superfamily
EXW25_RS29970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW25_RS29980	COG0577	efflux transmembrane transporter activity
EXW25_RS29980	COG1136	(ABC) transporter
EXW25_RS29990	COG0745	RESPONSE REGULATOR receiver
EXW25_RS29995	COG5002	protein histidine kinase activity
EXW25_RS29995	COG3850	Histidine kinase
EXW25_RS30005	COG0833	amino acid
EXW25_RS30010	COG2040	homocysteine
EXW25_RS30020	COG0584	glycerophosphoryl diester phosphodiesterase
EXW25_RS30055	COG3227	Zinc metalloprotease (Elastase)
EXW25_RS30085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW25_RS30090	COG0640	Transcriptional regulator
EXW25_RS30190	COG0756	dUTP diphosphatase activity
EXW25_RS30265	COG2814	Major facilitator Superfamily
EXW25_RS30270	COG1309	transcriptional regulator
EXW25_RS30305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW25_RS30615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW25_RS30695	COG0457	Tetratricopeptide repeat