locus-tag	class	description
I0K03_RS00010	COG0592	DNA-directed DNA polymerase activity
I0K03_RS00015	COG2501	S4 domain
I0K03_RS00025	COG0187	DNA topoisomerase II activity
I0K03_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K03_RS00065	COG0517	IMP dehydrogenase activity
I0K03_RS00065	COG0516	GMP reductase activity
I0K03_RS00070	COG1686	Belongs to the peptidase S11 family
I0K03_RS00100	COG1428	Deoxynucleoside kinase
I0K03_RS00105	COG1428	Deoxynucleoside kinase
I0K03_RS00110	COG1335	isochorismatase
I0K03_RS00115	COG0590	tRNA wobble adenosine to inosine editing
I0K03_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I0K03_RS00180	COG1982	Orn Lys Arg decarboxylase major
I0K03_RS00190	COG0470	DNA polymerase III
I0K03_RS00195	COG1774	PSP1 C-terminal conserved region
I0K03_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I0K03_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I0K03_RS00220	COG2002	toxin-antitoxin pair type II binding
I0K03_RS00230	COG0084	hydrolase, TatD family'
I0K03_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I0K03_RS00250	COG4466	Protein conserved in bacteria
I0K03_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0K03_RS00270	COG0251	oxidation-reduction process
I0K03_RS00275	COG2088	sporulation resulting in formation of a cellular spore
I0K03_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0K03_RS00305	COG2002	toxin-antitoxin pair type II binding
I0K03_RS00310	COG2244	polysaccharide biosynthetic process
I0K03_RS00315	COG3956	TIGRFAM MazG family protein
I0K03_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I0K03_RS00340	COG1098	S1 RNA binding domain
I0K03_RS00355	COG2208	phosphoserine phosphatase activity
I0K03_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K03_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0K03_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K03_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0K03_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K03_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0K03_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0K03_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I0K03_RS00420	COG1396	sequence-specific DNA binding
I0K03_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K03_RS00515	COG3880	PFAM UvrB UvrC protein
I0K03_RS00525	COG0542	response to heat
I0K03_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I0K03_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
I0K03_RS00560	COG1045	serine acetyltransferase
I0K03_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K03_RS00580	COG3688	RNA-binding protein containing a PIN domain
I0K03_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0K03_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K03_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
I0K03_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I0K03_RS00610	COG0081	regulation of translation
I0K03_RS00620	COG0222	ribosome binding
I0K03_RS00625	COG2813	Specifically methylates the guanine in position
I0K03_RS00640	COG1358	cellular component organization or biogenesis
I0K03_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I0K03_RS00665	COG0051	transcription antitermination factor activity, RNA binding
I0K03_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I0K03_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
I0K03_RS00760	COG1841	ribosomal large subunit assembly
I0K03_RS00770	COG0201	protein transport
I0K03_RS00780	COG0024	Methionine aminopeptidase
I0K03_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0K03_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0K03_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS00855	COG0489	protein tyrosine kinase activity
I0K03_RS00865	COG2194	sulfuric ester hydrolase activity
I0K03_RS00870	COG0726	polysaccharide deacetylase
I0K03_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I0K03_RS00955	COG4856	YbbR-like protein
I0K03_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS00995	COG2011	ABC-type metal ion transport system permease component
I0K03_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0K03_RS01005	COG1464	Belongs to the NlpA lipoprotein family
I0K03_RS01020	COG0277	FAD linked oxidase domain protein
I0K03_RS01025	COG2271	Major facilitator Superfamily
I0K03_RS01035	COG2814	Major facilitator Superfamily
I0K03_RS01050	COG0601	transmembrane transport
I0K03_RS01055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K03_RS01060	COG0444	Belongs to the ABC transporter superfamily
I0K03_RS01065	COG4608	Belongs to the ABC transporter superfamily
I0K03_RS01070	COG4166	transmembrane transport
I0K03_RS01080	COG2207	Transcriptional regulator
I0K03_RS01090	COG4166	transmembrane transport
I0K03_RS01095	COG4166	transmembrane transport
I0K03_RS01100	COG0656	L-ascorbic acid biosynthetic process
I0K03_RS01120	COG4149	molybdate abc transporter
I0K03_RS01125	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K03_RS01130	COG1910	domain protein
I0K03_RS01145	COG0697	spore germination
I0K03_RS01160	COG0204	Acyl-transferase
I0K03_RS01170	COG1609	Transcriptional regulator
I0K03_RS01180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS01195	COG5298	Protein conserved in bacteria
I0K03_RS01215	COG0488	(ABC) transporter
I0K03_RS01225	COG0747	negative chemotaxis
I0K03_RS01230	COG0601	transmembrane transport
I0K03_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K03_RS01240	COG0444	Belongs to the ABC transporter superfamily
I0K03_RS01245	COG4608	Belongs to the ABC transporter superfamily
I0K03_RS01250	COG0561	phosphatase activity
I0K03_RS01280	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I0K03_RS01285	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K03_RS01295	COG0531	amino acid
I0K03_RS01300	COG2814	Major facilitator Superfamily
I0K03_RS01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0K03_RS01320	COG4294	response to UV
I0K03_RS01325	COG0705	Rhomboid family
I0K03_RS01335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0K03_RS01340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K03_RS01345	COG0864	Transcriptional regulator
I0K03_RS01350	COG2337	Toxic component of a toxin-antitoxin (TA) module
I0K03_RS01355	COG2183	response to ionizing radiation
I0K03_RS01455	COG0802	atpase or kinase
I0K03_RS01460	COG1214	PFAM Peptidase M22, glycoprotease
I0K03_RS01465	COG0456	acetyltransferase
I0K03_RS01475	COG0488	(ABC) transporter
I0K03_RS01490	COG1266	CAAX protease self-immunity
I0K03_RS01500	COG0459	protein refolding
I0K03_RS01515	COG2252	PERMEase
I0K03_RS01525	COG5002	protein histidine kinase activity
I0K03_RS01550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K03_RS01600	COG1215	transferase activity, transferring glycosyl groups
I0K03_RS01620	COG0697	spore germination
I0K03_RS01665	COG2205	protein histidine kinase activity
I0K03_RS01670	COG0745	RESPONSE REGULATOR receiver
I0K03_RS01690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I0K03_RS01695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0K03_RS01700	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0K03_RS01710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0K03_RS01725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0K03_RS01735	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0K03_RS01740	COG0138	bifunctional purine biosynthesis protein purh
I0K03_RS01745	COG0151	Belongs to the GarS family
I0K03_RS01770	COG0210	DNA helicase
I0K03_RS01780	COG4851	CamS sex pheromone cAM373 precursor
I0K03_RS01795	COG1335	isochorismatase
I0K03_RS01805	COG2011	ABC-type metal ion transport system permease component
I0K03_RS01810	COG1464	Belongs to the NlpA lipoprotein family
I0K03_RS01825	COG0003	Pfam Anion-transporting ATPase
I0K03_RS01830	COG1846	Transcriptional regulator
I0K03_RS01835	COG4682	membrane
I0K03_RS01855	COG1597	lipid kinase activity
I0K03_RS01860	COG0546	phosphoglycolate phosphatase activity
I0K03_RS01865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS01880	COG2076	Multidrug Resistance protein
I0K03_RS01890	COG2309	aminopeptidase activity
I0K03_RS01905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS01915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K03_RS01920	COG5002	protein histidine kinase activity
I0K03_RS01925	COG4807	Protein conserved in bacteria
I0K03_RS01950	COG1757	Na H antiporter
I0K03_RS01955	COG1473	amidohydrolase
I0K03_RS01970	COG0450	alkyl hydroperoxide reductase
I0K03_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS01995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS02005	COG0492	ferredoxin-NADP+ reductase activity
I0K03_RS02015	COG0166	Belongs to the GPI family
I0K03_RS02040	COG5002	protein histidine kinase activity
I0K03_RS02060	COG3541	Predicted nucleotidyltransferase
I0K03_RS02065	COG2814	Major facilitator Superfamily
I0K03_RS02070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K03_RS02070	COG0723	plastoquinol--plastocyanin reductase activity
I0K03_RS02080	COG0765	amino acid transport
I0K03_RS02085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS02095	COG0840	transmembrane signaling receptor activity
I0K03_RS02120	COG0549	Belongs to the carbamate kinase family
I0K03_RS02135	COG0277	FAD linked oxidase domain protein
I0K03_RS02140	COG0366	Alpha amylase catalytic
I0K03_RS02145	COG1263	PTS System
I0K03_RS02145	COG2190	(PTS) system
I0K03_RS02145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS02175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0K03_RS02180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I0K03_RS02200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K03_RS02210	COG1116	anion transmembrane transporter activity
I0K03_RS02255	COG2270	Major facilitator Superfamily
I0K03_RS02280	COG4193	domain, Protein
I0K03_RS02290	COG2310	stress, protein
I0K03_RS02295	COG2310	stress, protein
I0K03_RS02300	COG2310	stress, protein
I0K03_RS02305	COG0861	Integral membrane protein TerC family
I0K03_RS02315	COG3853	Toxic anion resistance protein (TelA)
I0K03_RS02330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I0K03_RS02340	COG1295	ribonuclease BN
I0K03_RS02345	COG2217	Heavy metal translocating P-type atpase
I0K03_RS02350	COG0697	spore germination
I0K03_RS02370	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS02385	COG3871	stress protein (general stress protein 26)
I0K03_RS02390	COG0387	Pfam Sodium calcium exchanger
I0K03_RS02400	COG0535	radical SAM domain protein
I0K03_RS02420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K03_RS02440	COG3829	transcription factor binding
I0K03_RS02450	COG0833	amino acid
I0K03_RS02455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K03_RS02480	COG1263	PTS System
I0K03_RS02480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS02485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K03_RS02505	COG0463	Glycosyl transferase, family 2
I0K03_RS02515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0K03_RS02515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K03_RS02520	COG0463	Glycosyl transferase, family 2
I0K03_RS02525	COG1882	Formate acetyltransferase
I0K03_RS02530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0K03_RS02550	COG1228	amidohydrolase
I0K03_RS02555	COG1090	epimerase
I0K03_RS02585	COG1988	membrane-bound metal-dependent
I0K03_RS02590	COG1194	a g-specific adenine glycosylase
I0K03_RS02610	COG3557	Belongs to the UPF0374 family
I0K03_RS02615	COG1132	(ABC) transporter
I0K03_RS02620	COG4129	membrane
I0K03_RS02625	COG0067	glutamate synthase
I0K03_RS02625	COG0069	glutamate synthase activity
I0K03_RS02625	COG0070	glutamate synthase
I0K03_RS02630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I0K03_RS02635	COG4555	ABC transporter
I0K03_RS02655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0K03_RS02660	COG0735	belongs to the Fur family
I0K03_RS02780	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0K03_RS02805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0K03_RS02810	COG5001	Diguanylate cyclase
I0K03_RS02810	COG1716	ATPase activity
I0K03_RS02815	COG2766	serine protein kinase
I0K03_RS02820	COG2718	Belongs to the UPF0229 family
I0K03_RS02835	COG1585	Membrane protein implicated in regulation of membrane protease activity
I0K03_RS02840	COG2268	Band 7 protein
I0K03_RS02850	COG3290	protein histidine kinase activity
I0K03_RS02855	COG4565	transcriptional regulatory protein
I0K03_RS02860	COG2851	Citrate transporter
I0K03_RS02885	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K03_RS02890	COG3842	ATPase activity
I0K03_RS02895	COG1175	transmembrane transport
I0K03_RS02900	COG0395	ABC-type sugar transport system, permease component
I0K03_RS02910	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0K03_RS02915	COG0745	RESPONSE REGULATOR receiver
I0K03_RS02920	COG5002	protein histidine kinase activity
I0K03_RS02930	COG4990	cell redox homeostasis
I0K03_RS02940	COG3290	protein histidine kinase activity
I0K03_RS02945	COG4565	transcriptional regulatory protein
I0K03_RS02950	COG3493	citrate carrier protein
I0K03_RS02955	COG0281	malic enzyme
I0K03_RS02965	COG0697	spore germination
I0K03_RS02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS02980	COG5002	protein histidine kinase activity
I0K03_RS02985	COG0745	RESPONSE REGULATOR receiver
I0K03_RS02990	COG0456	acetyltransferase
I0K03_RS02990	COG0454	-acetyltransferase
I0K03_RS02995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K03_RS03000	COG3383	formate dehydrogenase (NAD+) activity
I0K03_RS03005	COG2427	Protein of unknown function (DUF1641)
I0K03_RS03020	COG0531	amino acid
I0K03_RS03030	COG0640	Transcriptional regulator
I0K03_RS03035	COG2217	Heavy metal translocating P-type atpase
I0K03_RS03040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I0K03_RS03055	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS03075	COG2720	vancomycin resistance protein
I0K03_RS03080	COG1316	TRANSCRIPTIONal
I0K03_RS03085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS03090	COG0346	lactoylglutathione lyase activity
I0K03_RS03095	COG1253	flavin adenine dinucleotide binding
I0K03_RS03100	COG1027	Aspartate ammonia-lyase
I0K03_RS03105	COG1620	l-lactate permease
I0K03_RS03120	COG3104	oligopeptide transport
I0K03_RS03125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS03130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS03135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS03145	COG2226	methyltransferase
I0K03_RS03155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K03_RS03165	COG4548	von Willebrand factor, type A
I0K03_RS03170	COG0714	Associated with various cellular activities
I0K03_RS03195	COG0531	amino acid
I0K03_RS03200	COG2188	Transcriptional regulator
I0K03_RS03205	COG1263	PTS System
I0K03_RS03205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS03210	COG0366	Alpha amylase catalytic
I0K03_RS03225	COG0697	spore germination
I0K03_RS03230	COG4585	Histidine kinase
I0K03_RS03235	COG2197	response regulator
I0K03_RS03240	COG1404	Belongs to the peptidase S8 family
I0K03_RS03250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K03_RS03255	COG1115	amino acid carrier protein
I0K03_RS03260	COG1126	abc transporter atp-binding protein
I0K03_RS03265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS03270	COG0765	amino acid transport
I0K03_RS03275	COG0765	amino acid transport
I0K03_RS03280	COG0833	amino acid
I0K03_RS03305	COG2378	regulation of single-species biofilm formation
I0K03_RS03310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0K03_RS03315	COG5002	protein histidine kinase activity
I0K03_RS03330	COG0659	secondary active sulfate transmembrane transporter activity
I0K03_RS03345	COG2271	Major facilitator Superfamily
I0K03_RS03350	COG1846	Transcriptional regulator
I0K03_RS03355	COG0477	Major facilitator Superfamily
I0K03_RS03360	COG1609	Transcriptional regulator
I0K03_RS03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0K03_RS03380	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS03385	COG1879	ABC-type sugar transport system periplasmic component
I0K03_RS03415	COG1063	alcohol dehydrogenase
I0K03_RS03465	COG0840	transmembrane signaling receptor activity
I0K03_RS03470	COG1388	LysM domain
I0K03_RS03470	COG3584	3D domain protein
I0K03_RS03475	COG1476	TRANSCRIPTIONal
I0K03_RS03495	COG3104	oligopeptide transport
I0K03_RS03500	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS03515	COG1113	amino acid transport
I0K03_RS03520	COG2252	PERMEase
I0K03_RS03545	COG0569	domain protein
I0K03_RS03545	COG0475	glutathione-regulated potassium exporter activity
I0K03_RS03560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0K03_RS03565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0K03_RS03570	COG0833	amino acid
I0K03_RS03575	COG4990	cell redox homeostasis
I0K03_RS03590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K03_RS03595	COG0697	spore germination
I0K03_RS03600	COG0531	amino acid
I0K03_RS03610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K03_RS03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K03_RS03620	COG1918	ferrous iron import across plasma membrane
I0K03_RS03620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K03_RS03625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K03_RS03630	COG0573	inorganic phosphate transmembrane transporter activity
I0K03_RS03635	COG0581	inorganic phosphate transmembrane transporter activity
I0K03_RS03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K03_RS03760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I0K03_RS03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K03_RS03785	COG1116	anion transmembrane transporter activity
I0K03_RS03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K03_RS03795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K03_RS03800	COG0352	thiamine-phosphate diphosphorylase activity
I0K03_RS03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K03_RS03810	COG2104	thiamine diphosphate biosynthetic process
I0K03_RS03815	COG2022	thiamine diphosphate biosynthetic process
I0K03_RS03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K03_RS03825	COG0351	phosphomethylpyrimidine kinase
I0K03_RS03855	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I0K03_RS03860	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I0K03_RS03865	COG2205	protein histidine kinase activity
I0K03_RS03870	COG2814	Major facilitator Superfamily
I0K03_RS03875	COG1846	Transcriptional regulator
I0K03_RS03895	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS03900	COG1129	ABC transporter
I0K03_RS03905	COG1879	ABC-type sugar transport system periplasmic component
I0K03_RS03910	COG2252	PERMEase
I0K03_RS03915	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS03975	COG0778	Nitroreductase
I0K03_RS03980	COG2719	SpoVR family
I0K03_RS04005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0K03_RS04010	COG1937	Protein conserved in bacteria
I0K03_RS04015	COG0425	Belongs to the sulfur carrier protein TusA family
I0K03_RS04015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS04020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS04025	COG0425	Belongs to the sulfur carrier protein TusA family
I0K03_RS04030	COG0425	Belongs to the sulfur carrier protein TusA family
I0K03_RS04030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS04040	COG2210	Belongs to the sulfur carrier protein TusA family
I0K03_RS04045	COG0730	response to heat
I0K03_RS04055	COG1316	TRANSCRIPTIONal
I0K03_RS04060	COG0604	alcohol dehydrogenase
I0K03_RS04065	COG1283	sodium-dependent phosphate transmembrane transporter activity
I0K03_RS04075	COG2814	Major facilitator Superfamily
I0K03_RS04085	COG3711	transcriptional antiterminator
I0K03_RS04085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K03_RS04090	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K03_RS04095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K03_RS04115	COG3584	3D domain protein
I0K03_RS04115	COG1388	LysM domain
I0K03_RS04120	COG0577	efflux transmembrane transporter activity
I0K03_RS04125	COG1136	(ABC) transporter
I0K03_RS04135	COG5522	Integral membrane protein (intg_mem_TP0381)
I0K03_RS04150	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS04155	COG3546	catalase activity
I0K03_RS04190	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS04225	COG0531	amino acid
I0K03_RS04230	COG0475	glutathione-regulated potassium exporter activity
I0K03_RS04240	COG1737	Transcriptional regulator
I0K03_RS04250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS04250	COG1263	PTS System
I0K03_RS04260	COG2259	Doxx family
I0K03_RS04280	COG1522	sequence-specific DNA binding
I0K03_RS04310	COG2076	Multidrug Resistance protein
I0K03_RS04315	COG1309	transcriptional regulator
I0K03_RS04320	COG2814	Major facilitator Superfamily
I0K03_RS04325	COG1733	regulation of RNA biosynthetic process
I0K03_RS04335	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K03_RS04345	COG4533	DNA binding
I0K03_RS04350	COG2814	Major facilitator Superfamily
I0K03_RS04360	COG0693	protein deglycase activity
I0K03_RS04370	COG0531	amino acid
I0K03_RS04375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0K03_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS04385	COG1132	(ABC) transporter
I0K03_RS04390	COG1132	(ABC) transporter
I0K03_RS04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS04400	COG0765	amino acid transport
I0K03_RS04405	COG1126	abc transporter atp-binding protein
I0K03_RS04420	COG0189	ligase activity
I0K03_RS04440	COG0028	Belongs to the TPP enzyme family
I0K03_RS04445	COG3527	Alpha-acetolactate decarboxylase
I0K03_RS04455	COG0561	phosphatase activity
I0K03_RS04465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K03_RS04480	COG0659	secondary active sulfate transmembrane transporter activity
I0K03_RS04490	COG1024	Enoyl-CoA hydratase
I0K03_RS04510	COG1363	Peptidase, m42
I0K03_RS04540	COG0579	oxidoreductase
I0K03_RS04560	COG0601	transmembrane transport
I0K03_RS04565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K03_RS04570	COG0444	Belongs to the ABC transporter superfamily
I0K03_RS04575	COG4608	Belongs to the ABC transporter superfamily
I0K03_RS04580	COG5444	nuclease activity
I0K03_RS04585	COG5444	nuclease activity
I0K03_RS04685	COG0477	Major facilitator Superfamily
I0K03_RS04690	COG3290	protein histidine kinase activity
I0K03_RS04695	COG4565	transcriptional regulatory protein
I0K03_RS04700	COG3181	Tripartite tricarboxylate transporter family receptor
I0K03_RS04750	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS04770	COG0477	Major facilitator Superfamily
I0K03_RS04810	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS04810	COG3409	Peptidoglycan-binding domain 1 protein
I0K03_RS04820	COG3711	transcriptional antiterminator
I0K03_RS04825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS04825	COG1263	PTS System
I0K03_RS04825	COG2190	(PTS) system
I0K03_RS04830	COG2723	6-phospho-beta-galactosidase activity
I0K03_RS04840	COG1183	phosphatidylcholine synthase activity
I0K03_RS04865	COG2814	Major facilitator Superfamily
I0K03_RS04870	COG0640	Transcriptional regulator
I0K03_RS04890	COG2376	Dihydroxyacetone kinase
I0K03_RS04900	COG2376	Dihydroxyacetone kinase
I0K03_RS04910	COG1959	2 iron, 2 sulfur cluster binding
I0K03_RS04925	COG0745	RESPONSE REGULATOR receiver
I0K03_RS04930	COG5002	protein histidine kinase activity
I0K03_RS04930	COG3850	Histidine kinase
I0K03_RS04965	COG3237	CsbD-like
I0K03_RS04990	COG1191	sigma factor activity
I0K03_RS05000	COG2208	phosphoserine phosphatase activity
I0K03_RS05005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K03_RS05010	COG2205	protein histidine kinase activity
I0K03_RS05010	COG2198	Histidine kinase
I0K03_RS05010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS05010	COG0784	Response regulator, receiver
I0K03_RS05070	COG0420	3'-5' exonuclease activity
I0K03_RS05075	COG4717	serine-type aminopeptidase activity
I0K03_RS05090	COG0714	Associated with various cellular activities
I0K03_RS05100	COG0346	lactoylglutathione lyase activity
I0K03_RS05105	COG0346	lactoylglutathione lyase activity
I0K03_RS05110	COG0457	Tetratricopeptide repeat
I0K03_RS05120	COG2267	carboxylic ester hydrolase activity
I0K03_RS05130	COG3620	sequence-specific DNA binding
I0K03_RS05135	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K03_RS05140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I0K03_RS05150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0K03_RS05170	COG0772	Belongs to the SEDS family
I0K03_RS05180	COG3973	AAA domain
I0K03_RS05190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K03_RS05215	COG0537	adenosine 5'-monophosphoramidase activity
I0K03_RS05220	COG1131	(ABC) transporter
I0K03_RS05225	COG4473	ABC transporter
I0K03_RS05240	COG1309	transcriptional regulator
I0K03_RS05250	COG3402	PFAM membrane-flanked domain
I0K03_RS05255	COG3428	Bacterial PH domain
I0K03_RS05305	COG3402	PFAM membrane-flanked domain
I0K03_RS05310	COG3428	Bacterial PH domain
I0K03_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
I0K03_RS05320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K03_RS05370	COG1309	transcriptional regulator
I0K03_RS05375	COG1511	domain protein
I0K03_RS05420	COG1609	Transcriptional regulator
I0K03_RS05430	COG1234	tRNA 3'-trailer cleavage
I0K03_RS05435	COG0095	Lipoate-protein ligase
I0K03_RS05445	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS05465	COG1408	metallophosphoesterase
I0K03_RS05475	COG1078	dGTPase activity
I0K03_RS05485	COG1595	DNA-templated transcription, initiation
I0K03_RS05490	COG3708	Transcriptional regulator
I0K03_RS05490	COG2207	Transcriptional regulator
I0K03_RS05505	COG2205	protein histidine kinase activity
I0K03_RS05510	COG0745	RESPONSE REGULATOR receiver
I0K03_RS05535	COG0501	Belongs to the peptidase M48B family
I0K03_RS05540	COG0840	transmembrane signaling receptor activity
I0K03_RS05545	COG0697	spore germination
I0K03_RS05550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I0K03_RS05555	COG2224	Isocitrate lyase
I0K03_RS05585	COG4903	ComK protein
I0K03_RS05590	COG0398	Pfam SNARE associated Golgi protein
I0K03_RS05610	COG0202	RNA polymerase activity
I0K03_RS05650	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K03_RS05675	COG0367	asparagine synthase
I0K03_RS05685	COG0753	catalase activity
I0K03_RS05690	COG0004	ammonium transporteR
I0K03_RS05710	COG2996	Protein conserved in bacteria
I0K03_RS05735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS05750	COG0561	phosphatase activity
I0K03_RS05770	COG2267	carboxylic ester hydrolase activity
I0K03_RS05785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K03_RS05790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0K03_RS05795	COG5504	Zn-dependent protease
I0K03_RS05805	COG0180	Tryptophanyl-tRNA synthetase
I0K03_RS05815	COG4166	transmembrane transport
I0K03_RS05820	COG0601	transmembrane transport
I0K03_RS05825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K03_RS05830	COG0444	Belongs to the ABC transporter superfamily
I0K03_RS05835	COG4608	Belongs to the ABC transporter superfamily
I0K03_RS05850	COG0534	Mate efflux family protein
I0K03_RS05855	COG4166	transmembrane transport
I0K03_RS05870	COG0861	Integral membrane protein TerC family
I0K03_RS05880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K03_RS05890	COG1164	Oligoendopeptidase f
I0K03_RS05900	COG2346	COG2346, Truncated hemoglobins
I0K03_RS05905	COG4116	CYTH
I0K03_RS05915	COG2357	RelA SpoT domain protein
I0K03_RS05925	COG0564	pseudouridine synthase activity
I0K03_RS05940	COG0772	Belongs to the SEDS family
I0K03_RS05945	COG1216	Glycosyl transferase, family 2
I0K03_RS05965	COG0463	Glycosyl transferase, family 2
I0K03_RS05965	COG0457	Tetratricopeptide repeat
I0K03_RS05985	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I0K03_RS06000	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0K03_RS06045	COG2153	protein acetylation
I0K03_RS06055	COG2382	esterase
I0K03_RS06070	COG5492	domain, Protein
I0K03_RS06075	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K03_RS06085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0K03_RS06085	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K03_RS06090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0K03_RS06105	COG0133	tryptophan synthase activity
I0K03_RS06120	COG1620	l-lactate permease
I0K03_RS06125	COG5634	Uncharacterized conserved protein (DUF2278)
I0K03_RS06180	COG2226	methyltransferase
I0K03_RS06200	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K03_RS06210	COG1476	TRANSCRIPTIONal
I0K03_RS06250	COG4152	abc transporter atp-binding protein
I0K03_RS06255	COG1668	transmembrane transport
I0K03_RS06290	COG1686	Belongs to the peptidase S11 family
I0K03_RS06295	COG0681	Belongs to the peptidase S26 family
I0K03_RS06330	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS06340	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0K03_RS06345	COG1177	transmembrane transport
I0K03_RS06350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I0K03_RS06360	COG2409	Drug exporters of the RND superfamily
I0K03_RS06370	COG0564	pseudouridine synthase activity
I0K03_RS06380	COG2340	Cysteine-rich secretory protein family
I0K03_RS06385	COG0247	lactate metabolic process
I0K03_RS06390	COG0277	FAD linked oxidase domain protein
I0K03_RS06395	COG3835	regulator
I0K03_RS06405	COG0745	RESPONSE REGULATOR receiver
I0K03_RS06410	COG5002	protein histidine kinase activity
I0K03_RS06415	COG2186	Transcriptional regulator
I0K03_RS06435	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I0K03_RS06445	COG2116	formate transmembrane transporter activity
I0K03_RS06450	COG0861	Integral membrane protein TerC family
I0K03_RS06455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K03_RS06465	COG2030	dehydratase
I0K03_RS06485	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS06490	COG3243	poly(R)-hydroxyalkanoic acid synthase
I0K03_RS06500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K03_RS06515	COG1840	ABC-type Fe3 transport system, periplasmic component
I0K03_RS06520	COG3842	ATPase activity
I0K03_RS06545	COG1349	DNA-binding transcription factor activity
I0K03_RS06555	COG0235	Class ii aldolase
I0K03_RS06565	COG2861	carbohydrate metabolic process
I0K03_RS06575	COG3852	Histidine kinase
I0K03_RS06580	COG1846	Transcriptional regulator
I0K03_RS06590	COG2318	DinB family
I0K03_RS06595	COG5002	protein histidine kinase activity
I0K03_RS06605	COG0720	synthase
I0K03_RS06620	COG4873	Protein conserved in bacteria
I0K03_RS06635	COG0456	acetyltransferase
I0K03_RS06650	COG1780	Probably involved in ribonucleotide reductase function
I0K03_RS06665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0K03_RS06670	COG0531	amino acid
I0K03_RS06675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0K03_RS06690	COG2204	response regulator
I0K03_RS06695	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS06705	COG1725	Transcriptional regulator
I0K03_RS06710	COG1131	(ABC) transporter
I0K03_RS06720	COG1131	(ABC) transporter
I0K03_RS06725	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K03_RS06740	COG1522	sequence-specific DNA binding
I0K03_RS06750	COG1335	isochorismatase
I0K03_RS06760	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K03_RS06765	COG2070	2-Nitropropane dioxygenase
I0K03_RS06770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K03_RS06780	COG1696	Membrane protein involved in D-alanine export
I0K03_RS06805	COG0716	FMN binding
I0K03_RS06840	COG0534	Mate efflux family protein
I0K03_RS06865	COG1846	Transcriptional regulator
I0K03_RS06875	COG1301	dicarboxylic acid transport
I0K03_RS06880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K03_RS06885	COG4709	membrane
I0K03_RS06890	COG3874	Sporulation protein YtfJ
I0K03_RS06915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS06920	COG0028	Belongs to the TPP enzyme family
I0K03_RS06925	COG0440	acetolactate synthase activity
I0K03_RS06945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I0K03_RS06975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I0K03_RS06985	COG0107	imidazoleglycerol-phosphate synthase activity
I0K03_RS06995	COG0140	phosphoribosyl-ATP diphosphatase activity
I0K03_RS07000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I0K03_RS07010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K03_RS07015	COG1183	phosphatidylcholine synthase activity
I0K03_RS07020	COG1368	sulfuric ester hydrolase activity
I0K03_RS07030	COG0019	diaminopimelate decarboxylase activity
I0K03_RS07050	COG0529	Catalyzes the synthesis of activated sulfate
I0K03_RS07055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K03_RS07075	COG1648	precorrin-2 dehydrogenase activity
I0K03_RS07080	COG0733	neurotransmitter:sodium symporter activity
I0K03_RS07105	COG1757	Na H antiporter
I0K03_RS07120	COG4758	membrane
I0K03_RS07125	COG4585	Histidine kinase
I0K03_RS07130	COG2197	response regulator
I0K03_RS07140	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS07150	COG2226	methyltransferase
I0K03_RS07190	COG0730	response to heat
I0K03_RS07195	COG0306	phosphate transporter
I0K03_RS07200	COG1392	Phosphate transport regulator
I0K03_RS07205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS07220	COG3852	Histidine kinase
I0K03_RS07225	COG1801	Protein of unknown function DUF72
I0K03_RS07235	COG0582	viral genome integration into host DNA
I0K03_RS07240	COG5002	protein histidine kinase activity
I0K03_RS07255	COG0392	lysyltransferase activity
I0K03_RS07255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I0K03_RS07270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K03_RS07275	COG1686	Belongs to the peptidase S11 family
I0K03_RS07280	COG2715	membrane protein required for spore maturation
I0K03_RS07285	COG0700	Nucleoside recognition
I0K03_RS07290	COG1187	pseudouridine synthase activity
I0K03_RS07300	COG1333	cytochrome c biogenesis protein
I0K03_RS07305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K03_RS07310	COG0745	RESPONSE REGULATOR receiver
I0K03_RS07315	COG5002	protein histidine kinase activity
I0K03_RS07320	COG2096	Adenosyltransferase
I0K03_RS07325	COG4942	peptidase
I0K03_RS07335	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I0K03_RS07340	COG1141	Ferredoxin
I0K03_RS07345	COG4955	Helix-turn-helix domain
I0K03_RS07350	COG0514	ATP-dependent DNA helicase (RecQ)
I0K03_RS07355	COG1266	CAAX protease self-immunity
I0K03_RS07365	COG1408	metallophosphoesterase
I0K03_RS07370	COG0789	Transcriptional regulator
I0K03_RS07375	COG4862	establishment of competence for transformation
I0K03_RS07380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0K03_RS07400	COG0492	ferredoxin-NADP+ reductase activity
I0K03_RS07475	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K03_RS07490	COG0142	geranyltranstransferase activity
I0K03_RS07500	COG0142	geranyltranstransferase activity
I0K03_RS07525	COG0457	Tetratricopeptide repeat
I0K03_RS07545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K03_RS07550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K03_RS07550	COG2010	Cytochrome c
I0K03_RS07555	COG4347	Protein of unknown function (DUF1405)
I0K03_RS07570	COG2738	Putative neutral zinc metallopeptidase
I0K03_RS07580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS07585	COG1694	Mazg nucleotide pyrophosphohydrolase
I0K03_RS07600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K03_RS07605	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS07640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0K03_RS07640	COG1199	ATP-dependent helicase activity
I0K03_RS07660	COG3935	DnaD domain protein
I0K03_RS07665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I0K03_RS07675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS07675	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K03_RS07720	COG3599	regulation of cell shape
I0K03_RS07730	COG0116	Belongs to the methyltransferase superfamily
I0K03_RS07740	COG1199	ATP-dependent helicase activity
I0K03_RS07745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I0K03_RS07755	COG3173	Aminoglycoside phosphotransferase
I0K03_RS07760	COG0024	Methionine aminopeptidase
I0K03_RS07770	COG2233	PERMEase
I0K03_RS07775	COG2311	Membrane
I0K03_RS07785	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K03_RS07795	COG0456	acetyltransferase
I0K03_RS07835	COG0754	glutathionylspermidine amidase activity
I0K03_RS07850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K03_RS07865	COG0454	-acetyltransferase
I0K03_RS07885	COG0328	RNA-DNA hybrid ribonuclease activity
I0K03_RS07920	COG3403	YqcI/YcgG family
I0K03_RS07925	COG1280	lysine exporter protein (LysE YggA)
I0K03_RS07940	COG3162	membrane
I0K03_RS07945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K03_RS07950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K03_RS07960	COG0475	glutathione-regulated potassium exporter activity
I0K03_RS07965	COG0789	Transcriptional regulator
I0K03_RS07965	COG4978	Transcriptional regulator
I0K03_RS07975	COG2323	membrane
I0K03_RS07980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I0K03_RS08030	COG1923	regulation of RNA biosynthetic process
I0K03_RS08040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K03_RS08045	COG1360	Flagellar Motor Protein
I0K03_RS08050	COG2201	protein-glutamate methylesterase activity
I0K03_RS08055	COG2198	Histidine kinase
I0K03_RS08055	COG0643	Histidine kinase
I0K03_RS08060	COG1776	CheC inhibitor of MCP methylation
I0K03_RS08060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K03_RS08075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K03_RS08095	COG1256	bacterial-type flagellum assembly
I0K03_RS08100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K03_RS08120	COG1815	bacterial-type flagellum-dependent cell motility
I0K03_RS08125	COG1558	bacterial-type flagellum-dependent cell motility
I0K03_RS08135	COG1766	The M ring may be actively involved in energy transduction
I0K03_RS08140	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K03_RS08150	COG1157	protein secretion by the type III secretion system
I0K03_RS08170	COG1749	Flagellar hook protein flgE
I0K03_RS08185	COG0835	chemotaxis
I0K03_RS08185	COG0784	Response regulator, receiver
I0K03_RS08195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K03_RS08200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K03_RS08205	COG0741	lytic transglycosylase activity
I0K03_RS08215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K03_RS08220	COG1776	CheC inhibitor of MCP methylation
I0K03_RS08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K03_RS08230	COG1338	Plays a role in the flagellum-specific transport system
I0K03_RS08235	COG1987	bacterial-type flagellum assembly
I0K03_RS08245	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K03_RS08250	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K03_RS08255	COG1419	protein localization to endoplasmic reticulum
I0K03_RS08260	COG4786	Flagellar basal body rod
I0K03_RS08300	COG2329	Antibiotic biosynthesis monooxygenase
I0K03_RS08315	COG2814	Major facilitator Superfamily
I0K03_RS08325	COG0583	DNA-binding transcription factor activity
I0K03_RS08330	COG3842	ATPase activity
I0K03_RS08335	COG1840	ABC-type Fe3 transport system, periplasmic component
I0K03_RS08345	COG1234	tRNA 3'-trailer cleavage
I0K03_RS08380	COG0406	alpha-ribazole phosphatase activity
I0K03_RS08400	COG1846	Transcriptional regulator
I0K03_RS08410	COG0367	asparagine synthase
I0K03_RS08440	COG1802	Transcriptional regulator
I0K03_RS08445	COG0697	spore germination
I0K03_RS08455	COG0523	cobalamin synthesis protein
I0K03_RS08460	COG0701	Predicted permease
I0K03_RS08470	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS08470	COG1216	Glycosyl transferase, family 2
I0K03_RS08475	COG1757	Na H antiporter
I0K03_RS08480	COG0789	Transcriptional regulator
I0K03_RS08485	COG4221	oxidoreductase activity
I0K03_RS08505	COG0534	Mate efflux family protein
I0K03_RS08510	COG3340	Belongs to the peptidase S51 family
I0K03_RS08530	COG0785	Cytochrome C biogenesis protein
I0K03_RS08535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K03_RS08555	COG2733	membrane
I0K03_RS08590	COG1131	(ABC) transporter
I0K03_RS08605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K03_RS08610	COG0528	UMP kinase activity
I0K03_RS08620	COG1027	Aspartate ammonia-lyase
I0K03_RS08625	COG0281	malic enzyme
I0K03_RS08630	COG4191	Histidine kinase
I0K03_RS08635	COG0784	Response regulator, receiver
I0K03_RS08640	COG1846	Transcriptional regulator
I0K03_RS08650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K03_RS08665	COG3620	sequence-specific DNA binding
I0K03_RS08695	COG2814	Major facilitator Superfamily
I0K03_RS08710	COG0477	Major facilitator Superfamily
I0K03_RS08715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K03_RS08725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K03_RS08730	COG2223	nitrite transmembrane transporter activity
I0K03_RS08735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K03_RS08750	COG2244	polysaccharide biosynthetic process
I0K03_RS08755	COG0733	neurotransmitter:sodium symporter activity
I0K03_RS08765	COG5566	PFAM Mor transcription activator
I0K03_RS08770	COG2323	membrane
I0K03_RS08790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K03_RS08800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS08805	COG0028	Belongs to the TPP enzyme family
I0K03_RS08825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0K03_RS08845	COG2814	Major facilitator Superfamily
I0K03_RS08850	COG3384	dioxygenase
I0K03_RS08860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K03_RS08880	COG4166	transmembrane transport
I0K03_RS08890	COG0535	radical SAM domain protein
I0K03_RS08895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS08915	COG1914	H( )-stimulated, divalent metal cation uptake system
I0K03_RS08930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K03_RS08935	COG0531	amino acid
I0K03_RS08955	COG1280	lysine exporter protein (LysE YggA)
I0K03_RS08960	COG2390	Transcriptional regulator
I0K03_RS08970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS08975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I0K03_RS08980	COG0295	cytidine deaminase activity
I0K03_RS08990	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K03_RS09010	COG0583	DNA-binding transcription factor activity
I0K03_RS09025	COG0006	proline dipeptidase activity
I0K03_RS09030	COG2132	Multicopper oxidase
I0K03_RS09080	COG1760	l-serine dehydratase
I0K03_RS09085	COG1760	l-serine dehydratase
I0K03_RS09090	COG0814	amino acid
I0K03_RS09100	COG1136	(ABC) transporter
I0K03_RS09105	COG0577	efflux transmembrane transporter activity
I0K03_RS09110	COG0745	RESPONSE REGULATOR receiver
I0K03_RS09115	COG2205	protein histidine kinase activity
I0K03_RS09145	COG0772	Belongs to the SEDS family
I0K03_RS09150	COG2239	Acts as a magnesium transporter
I0K03_RS09160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K03_RS09180	COG1073	alpha beta
I0K03_RS09205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K03_RS09220	COG2409	Drug exporters of the RND superfamily
I0K03_RS09250	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS09260	COG1910	domain protein
I0K03_RS09280	COG1280	lysine exporter protein (LysE YggA)
I0K03_RS09285	COG3403	YqcI/YcgG family
I0K03_RS09300	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K03_RS09305	COG0561	phosphatase activity
I0K03_RS09310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I0K03_RS09320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I0K03_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS09390	COG1787	Restriction endonuclease
I0K03_RS09390	COG1715	Restriction endonuclease
I0K03_RS09410	COG2372	response to copper ion
I0K03_RS09410	COG1276	copper resistance
I0K03_RS09415	COG4549	nuclear export factor GLE1
I0K03_RS09420	COG0697	spore germination
I0K03_RS09425	COG0583	DNA-binding transcription factor activity
I0K03_RS09430	COG1959	2 iron, 2 sulfur cluster binding
I0K03_RS09435	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K03_RS09440	COG0778	Nitroreductase
I0K03_RS09450	COG0628	permease
I0K03_RS09465	COG1231	oxidoreductase activity
I0K03_RS09470	COG0523	cobalamin synthesis protein
I0K03_RS09480	COG0411	ABC transporter
I0K03_RS09490	COG0559	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS09500	COG0583	DNA-binding transcription factor activity
I0K03_RS09530	COG1271	oxidase subunit
I0K03_RS09535	COG1294	oxidase, subunit
I0K03_RS09540	COG4988	ABC transporter
I0K03_RS09545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I0K03_RS09550	COG0463	Glycosyl transferase, family 2
I0K03_RS09570	COG1686	Belongs to the peptidase S11 family
I0K03_RS09580	COG0791	NLP P60 protein
I0K03_RS09580	COG1388	LysM domain
I0K03_RS09590	COG1132	(ABC) transporter
I0K03_RS09595	COG0745	RESPONSE REGULATOR receiver
I0K03_RS09600	COG5002	protein histidine kinase activity
I0K03_RS09610	COG0300	oxidoreductase activity
I0K03_RS09635	COG5658	integral membrane protein
I0K03_RS09650	COG0460	homoserine dehydrogenase
I0K03_RS09660	COG0083	homoserine kinase activity
I0K03_RS09675	COG1316	TRANSCRIPTIONal
I0K03_RS09685	COG0745	RESPONSE REGULATOR receiver
I0K03_RS09690	COG5002	protein histidine kinase activity
I0K03_RS09705	COG1285	pathogenesis
I0K03_RS09710	COG1247	-acetyltransferase
I0K03_RS09730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K03_RS09740	COG1082	Xylose isomerase domain protein TIM barrel
I0K03_RS09750	COG2814	Major facilitator Superfamily
I0K03_RS09755	COG1279	arginine transmembrane transporter activity
I0K03_RS09760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS09770	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K03_RS09805	COG0577	efflux transmembrane transporter activity
I0K03_RS09810	COG2002	toxin-antitoxin pair type II binding
I0K03_RS09815	COG1404	Belongs to the peptidase S8 family
I0K03_RS09820	COG0640	Transcriptional regulator
I0K03_RS09825	COG0667	Aldo Keto reductase
I0K03_RS09865	COG3949	Membrane
I0K03_RS09870	COG0783	Belongs to the Dps family
I0K03_RS09885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K03_RS09895	COG1231	oxidoreductase activity
I0K03_RS09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS09905	COG4989	oxidoreductase activity
I0K03_RS09910	COG0523	cobalamin synthesis protein
I0K03_RS09920	COG0803	Belongs to the bacterial solute-binding protein 9 family
I0K03_RS09930	COG0702	epimerase
I0K03_RS09940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K03_RS09950	COG4166	transmembrane transport
I0K03_RS09955	COG0346	lactoylglutathione lyase activity
I0K03_RS09975	COG5337	Spore coat protein CotH
I0K03_RS09980	COG1051	belongs to the nudix hydrolase family
I0K03_RS09985	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS09990	COG2244	polysaccharide biosynthetic process
I0K03_RS10000	COG0701	Predicted permease
I0K03_RS10005	COG3689	TIGRFAM TIGR03943 family protein
I0K03_RS10010	COG1607	acyl-coa hydrolase
I0K03_RS10020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K03_RS10035	COG0702	epimerase
I0K03_RS10040	COG2839	Protein conserved in bacteria
I0K03_RS10045	COG1253	flavin adenine dinucleotide binding
I0K03_RS10070	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS10075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K03_RS10095	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS10105	COG1876	peptidase activity
I0K03_RS10115	COG0154	amidase activity
I0K03_RS10120	COG2211	Major facilitator Superfamily
I0K03_RS10135	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS10145	COG0561	phosphatase activity
I0K03_RS10150	COG1846	Transcriptional regulator
I0K03_RS10155	COG2814	Major facilitator Superfamily
I0K03_RS10165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K03_RS10180	COG1819	glycosyl
I0K03_RS10185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS10190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS10220	COG0456	acetyltransferase
I0K03_RS10325	COG3874	Sporulation protein YtfJ
I0K03_RS10350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K03_RS10370	COG0346	lactoylglutathione lyase activity
I0K03_RS10405	COG0426	domain, Protein
I0K03_RS10405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K03_RS10415	COG0386	Belongs to the glutathione peroxidase family
I0K03_RS10420	COG1305	Transglutaminase-like
I0K03_RS10425	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I0K03_RS10430	COG0714	Associated with various cellular activities
I0K03_RS10435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I0K03_RS10440	COG1140	nitrate reductase beta subunit
I0K03_RS10445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I0K03_RS10450	COG2181	nitrate reductase activity
I0K03_RS10455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K03_RS10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K03_RS10465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K03_RS10470	COG0303	'Molybdopterin
I0K03_RS10475	COG0314	molybdopterin synthase activity
I0K03_RS10485	COG2223	nitrite transmembrane transporter activity
I0K03_RS10495	COG1648	precorrin-2 dehydrogenase activity
I0K03_RS10505	COG1587	Uroporphyrinogen-III synthase
I0K03_RS10505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0K03_RS10510	COG2146	nitrite reductase [NAD(P)H] activity
I0K03_RS10515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K03_RS10520	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I0K03_RS10550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS10595	COG2359	stage V sporulation protein S
I0K03_RS10605	COG1418	mRNA catabolic process
I0K03_RS10610	COG0488	(ABC) transporter
I0K03_RS10625	COG0629	single-stranded DNA binding
I0K03_RS10635	COG1413	lyase activity
I0K03_RS10650	COG2521	methyltransferase
I0K03_RS10650	COG2136	Putative SAM-dependent methyltransferase
I0K03_RS10655	COG0018	arginyl-trna synthetase
I0K03_RS10690	COG1309	transcriptional regulator
I0K03_RS10705	COG0017	Asparaginyl-tRNA synthetase
I0K03_RS10710	COG0733	neurotransmitter:sodium symporter activity
I0K03_RS10715	COG2267	carboxylic ester hydrolase activity
I0K03_RS10735	COG2610	gluconate transmembrane transporter activity
I0K03_RS10745	COG1794	racemase activity, acting on amino acids and derivatives
I0K03_RS10755	COG0456	acetyltransferase
I0K03_RS10760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I0K03_RS10775	COG0546	phosphoglycolate phosphatase activity
I0K03_RS10790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K03_RS10805	COG0768	penicillin binding
I0K03_RS10815	COG0204	Acyl-transferase
I0K03_RS10820	COG1272	protein, Hemolysin III
I0K03_RS10830	COG0805	protein transport
I0K03_RS10840	COG1307	EDD domain protein, DegV family
I0K03_RS10845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I0K03_RS10850	COG1999	signal sequence binding
I0K03_RS10855	COG0071	Belongs to the small heat shock protein (HSP20) family
I0K03_RS10860	COG0367	asparagine synthase
I0K03_RS10875	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS10880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS10885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS10900	COG1335	isochorismatase
I0K03_RS10905	COG1051	belongs to the nudix hydrolase family
I0K03_RS10910	COG0668	transmembrane transport
I0K03_RS10915	COG2203	Gaf domain
I0K03_RS10915	COG4585	Histidine kinase
I0K03_RS10920	COG2197	response regulator
I0K03_RS10925	COG1737	Transcriptional regulator
I0K03_RS10930	COG1064	alcohol dehydrogenase
I0K03_RS10990	COG0517	IMP dehydrogenase activity
I0K03_RS10990	COG1125	glycine betaine transport
I0K03_RS10995	COG1174	glycine betaine transport
I0K03_RS11030	COG1253	flavin adenine dinucleotide binding
I0K03_RS11035	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS11040	COG5506	Protein of unknown function (DUF1694)
I0K03_RS11055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K03_RS11060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0K03_RS11065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0K03_RS11070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K03_RS11075	COG0456	acetyltransferase
I0K03_RS11080	COG3829	transcription factor binding
I0K03_RS11085	COG1509	lysine 2,3-aminomutase activity
I0K03_RS11120	COG3064	Membrane
I0K03_RS11120	COG4991	sh3 domain protein
I0K03_RS11120	COG0515	serine threonine protein kinase
I0K03_RS11130	COG0671	phosphoesterase, PA-phosphatase related
I0K03_RS11135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K03_RS11140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K03_RS11190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K03_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS11235	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K03_RS11235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS11245	COG2814	Major facilitator Superfamily
I0K03_RS11255	COG0372	Belongs to the citrate synthase family
I0K03_RS11260	COG2079	MmgE PrpD family protein
I0K03_RS11265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I0K03_RS11270	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS11275	COG2084	Dehydrogenase
I0K03_RS11285	COG1280	lysine exporter protein (LysE YggA)
I0K03_RS11290	COG1024	Enoyl-CoA hydratase
I0K03_RS11305	COG0420	3'-5' exonuclease activity
I0K03_RS11335	COG2223	nitrite transmembrane transporter activity
I0K03_RS11340	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS11345	COG1169	isochorismate synthase
I0K03_RS11350	COG1021	2,3-dihydroxybenzoate-AMP ligase
I0K03_RS11355	COG3433	isochorismatase activity
I0K03_RS11355	COG1535	isochorismatase
I0K03_RS11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0K03_RS11365	COG3251	PFAM MbtH domain protein
I0K03_RS11370	COG2814	Major facilitator Superfamily
I0K03_RS11385	COG0776	regulation of translation
I0K03_RS11395	COG2318	DinB family
I0K03_RS11405	COG1115	amino acid carrier protein
I0K03_RS11415	COG2329	Antibiotic biosynthesis monooxygenase
I0K03_RS11420	COG1187	pseudouridine synthase activity
I0K03_RS11425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K03_RS11430	COG1136	(ABC) transporter
I0K03_RS11440	COG0596	Alpha beta hydrolase
I0K03_RS11455	COG0028	Belongs to the TPP enzyme family
I0K03_RS11490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K03_RS11500	COG2207	Transcriptional regulator
I0K03_RS11525	COG2755	lipolytic protein G-D-S-L family
I0K03_RS11525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I0K03_RS11535	COG5002	protein histidine kinase activity
I0K03_RS11545	COG0745	RESPONSE REGULATOR receiver
I0K03_RS11565	COG1846	Transcriptional regulator
I0K03_RS11580	COG1309	transcriptional regulator
I0K03_RS11605	COG1247	-acetyltransferase
I0K03_RS11630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K03_RS11640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS11675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K03_RS11680	COG0583	DNA-binding transcription factor activity
I0K03_RS11685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0K03_RS11690	COG2258	MOSC domain
I0K03_RS11705	COG1132	(ABC) transporter
I0K03_RS11710	COG1132	(ABC) transporter
I0K03_RS11725	COG1396	sequence-specific DNA binding
I0K03_RS11760	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I0K03_RS11765	COG1595	DNA-templated transcription, initiation
I0K03_RS11790	COG1649	PFAM Uncharacterised BCR, COG1649
I0K03_RS11810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I0K03_RS11815	COG2971	BadF BadG BcrA BcrD
I0K03_RS11845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS11875	COG2226	methyltransferase
I0K03_RS11880	COG3961	Belongs to the TPP enzyme family
I0K03_RS11915	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K03_RS11945	COG2002	toxin-antitoxin pair type II binding
I0K03_RS11955	COG0730	response to heat
I0K03_RS11960	COG0110	maltose O-acetyltransferase activity
I0K03_RS11965	COG1686	Belongs to the peptidase S11 family
I0K03_RS11980	COG0768	penicillin binding
I0K03_RS11985	COG1595	DNA-templated transcription, initiation
I0K03_RS11995	COG0768	penicillin binding
I0K03_RS12000	COG0768	penicillin binding
I0K03_RS12045	COG0697	spore germination
I0K03_RS12055	COG3397	chitin binding
I0K03_RS12060	COG0823	Involved in the tonB-independent uptake of proteins
I0K03_RS12070	COG1408	metallophosphoesterase
I0K03_RS12080	COG1131	(ABC) transporter
I0K03_RS12090	COG1309	transcriptional regulator
I0K03_RS12100	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS12105	COG0439	Biotin carboxylase
I0K03_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
I0K03_RS12115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0K03_RS12120	COG1024	Enoyl-CoA hydratase
I0K03_RS12125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0K03_RS12130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K03_RS12190	COG2318	DinB family
I0K03_RS12195	COG1686	Belongs to the peptidase S11 family
I0K03_RS12220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K03_RS12240	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS12245	COG2207	Transcriptional regulator
I0K03_RS12285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0K03_RS12315	COG1733	regulation of RNA biosynthetic process
I0K03_RS12320	COG2226	methyltransferase
I0K03_RS12350	COG0697	spore germination
I0K03_RS12355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS12380	COG2323	membrane
I0K03_RS12390	COG0693	protein deglycase activity
I0K03_RS12400	COG3386	PFAM SMP-30 Gluconolaconase
I0K03_RS12410	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I0K03_RS12415	COG3773	Cell wall hydrolase
I0K03_RS12425	COG0745	RESPONSE REGULATOR receiver
I0K03_RS12430	COG2205	protein histidine kinase activity
I0K03_RS12440	COG0583	DNA-binding transcription factor activity
I0K03_RS12445	COG0667	Aldo Keto reductase
I0K03_RS12450	COG0488	(ABC) transporter
I0K03_RS12460	COG1136	(ABC) transporter
I0K03_RS12465	COG0577	efflux transmembrane transporter activity
I0K03_RS12490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS12500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K03_RS12605	COG0463	Glycosyl transferase, family 2
I0K03_RS12635	COG2124	cytochrome p450
I0K03_RS12670	COG0561	phosphatase activity
I0K03_RS12675	COG5002	protein histidine kinase activity
I0K03_RS12680	COG0768	penicillin binding
I0K03_RS12690	COG1819	glycosyl
I0K03_RS12695	COG1794	racemase activity, acting on amino acids and derivatives
I0K03_RS12720	COG2205	protein histidine kinase activity
I0K03_RS12730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K03_RS12735	COG0604	alcohol dehydrogenase
I0K03_RS12740	COG0671	phosphoesterase, PA-phosphatase related
I0K03_RS12745	COG0768	penicillin binding
I0K03_RS12805	COG2814	Major facilitator Superfamily
I0K03_RS12820	COG0584	glycerophosphoryl diester phosphodiesterase
I0K03_RS12840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS12845	COG0697	spore germination
I0K03_RS12875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K03_RS12885	COG2223	nitrite transmembrane transporter activity
I0K03_RS12895	COG2816	NAD+ diphosphatase activity
I0K03_RS12900	COG0592	DNA-directed DNA polymerase activity
I0K03_RS12925	COG3878	Protein conserved in bacteria
I0K03_RS12945	COG4667	esterase of the alpha-beta hydrolase superfamily
I0K03_RS12985	COG0322	excinuclease ABC activity
I0K03_RS13010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K03_RS13035	COG1011	Hydrolase
I0K03_RS13040	COG0745	RESPONSE REGULATOR receiver
I0K03_RS13045	COG5002	protein histidine kinase activity
I0K03_RS13080	COG1136	(ABC) transporter
I0K03_RS13085	COG0577	efflux transmembrane transporter activity
I0K03_RS13100	COG0657	acetylesterase activity
I0K03_RS13105	COG1523	belongs to the glycosyl hydrolase 13 family
I0K03_RS13110	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS13115	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS13125	COG0201	protein transport
I0K03_RS13130	COG0697	spore germination
I0K03_RS13135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS13170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS13185	COG2959	enzyme of heme biosynthesis
I0K03_RS13225	COG1309	transcriptional regulator
I0K03_RS13235	COG3284	Transcriptional regulator
I0K03_RS13255	COG1349	DNA-binding transcription factor activity
I0K03_RS13275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K03_RS13280	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K03_RS13285	COG0022	dehydrogenase e1 component
I0K03_RS13290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K03_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS13330	COG4176	ABC-type proline glycine betaine transport system permease component
I0K03_RS13335	COG0517	IMP dehydrogenase activity
I0K03_RS13335	COG4175	Glycine betaine
I0K03_RS13365	COG2153	protein acetylation
I0K03_RS13380	COG3397	chitin binding
I0K03_RS13390	COG1819	glycosyl
I0K03_RS13410	COG2205	protein histidine kinase activity
I0K03_RS13415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K03_RS13420	COG2315	Protein conserved in bacteria
I0K03_RS13470	COG3973	AAA domain
I0K03_RS13480	COG0514	ATP-dependent DNA helicase (RecQ)
I0K03_RS13505	COG4637	Psort location Cytoplasmic, score
I0K03_RS13520	COG3397	chitin binding
I0K03_RS13525	COG2318	DinB family
I0K03_RS13540	COG1162	GTPase activity
I0K03_RS13545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0K03_RS13550	COG1115	amino acid carrier protein
I0K03_RS13555	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS13560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0K03_RS13565	COG3938	Belongs to the proline racemase family
I0K03_RS13570	COG3938	Belongs to the proline racemase family
I0K03_RS13575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K03_RS13625	COG1078	dGTPase activity
I0K03_RS13630	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS13640	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K03_RS13645	COG4166	transmembrane transport
I0K03_RS13655	COG4948	Mandelate Racemase Muconate Lactonizing
I0K03_RS13700	COG2936	dipeptidyl-peptidase activity
I0K03_RS13705	COG5002	protein histidine kinase activity
I0K03_RS13705	COG3850	Histidine kinase
I0K03_RS13735	COG1164	Oligoendopeptidase f
I0K03_RS13740	COG0456	acetyltransferase
I0K03_RS13745	COG1307	EDD domain protein, DegV family
I0K03_RS13785	COG2814	Major facilitator Superfamily
I0K03_RS13795	COG1664	Polymer-forming cytoskeletal
I0K03_RS13800	COG0789	Transcriptional regulator
I0K03_RS13805	COG4533	DNA binding
I0K03_RS13810	COG0477	Major facilitator Superfamily
I0K03_RS13810	COG2814	Major facilitator Superfamily
I0K03_RS13835	COG2261	transglycosylase associated protein
I0K03_RS13850	COG2226	methyltransferase
I0K03_RS13885	COG0436	Aminotransferase
I0K03_RS13890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0K03_RS13900	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I0K03_RS13915	COG1131	(ABC) transporter
I0K03_RS13960	COG0628	permease
I0K03_RS13970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K03_RS13975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K03_RS13980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K03_RS14020	COG2746	aminoglycoside 3-N-acetyltransferase activity
I0K03_RS14050	COG0697	spore germination
I0K03_RS14085	COG0346	lactoylglutathione lyase activity
I0K03_RS14090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS14115	COG2814	Major facilitator Superfamily
I0K03_RS14120	COG0861	Integral membrane protein TerC family
I0K03_RS14125	COG1368	sulfuric ester hydrolase activity
I0K03_RS14130	COG0488	(ABC) transporter
I0K03_RS14135	COG1033	growth of symbiont in host cell
I0K03_RS14135	COG2409	Drug exporters of the RND superfamily
I0K03_RS14140	COG1309	transcriptional regulator
I0K03_RS14155	COG0287	Prephenate dehydrogenase
I0K03_RS14170	COG1605	Chorismate mutase
I0K03_RS14170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I0K03_RS14215	COG3584	3D domain protein
I0K03_RS14215	COG1388	LysM domain
I0K03_RS14225	COG0346	lactoylglutathione lyase activity
I0K03_RS14230	COG0519	Catalyzes the synthesis of GMP from XMP
I0K03_RS14235	COG0431	NADPH-dependent FMN reductase
I0K03_RS14260	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS14265	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS14275	COG2390	Transcriptional regulator
I0K03_RS14280	COG1070	Carbohydrate kinase
I0K03_RS14315	COG2329	Antibiotic biosynthesis monooxygenase
I0K03_RS14335	COG1472	Belongs to the glycosyl hydrolase 3 family
I0K03_RS14340	COG2207	Transcriptional regulator
I0K03_RS14345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS14350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I0K03_RS14355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I0K03_RS14360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K03_RS14365	COG4187	Peptidase family M20/M25/M40
I0K03_RS14370	COG1414	Transcriptional regulator
I0K03_RS14375	COG0833	amino acid
I0K03_RS14390	COG3239	Fatty acid desaturase
I0K03_RS14400	COG1785	Belongs to the alkaline phosphatase family
I0K03_RS14410	COG3655	Transcriptional regulator
I0K03_RS14435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS14440	COG0346	lactoylglutathione lyase activity
I0K03_RS14460	COG0714	Associated with various cellular activities
I0K03_RS14485	COG0753	catalase activity
I0K03_RS14525	COG0714	Associated with various cellular activities
I0K03_RS14555	COG0778	Nitroreductase
I0K03_RS14560	COG1846	Transcriptional regulator
I0K03_RS14580	COG3831	ATPase activity
I0K03_RS14580	COG4884	unkown
I0K03_RS14615	COG0456	acetyltransferase
I0K03_RS14635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS14680	COG0730	response to heat
I0K03_RS14690	COG0833	amino acid
I0K03_RS14700	COG4335	DNA alkylation repair
I0K03_RS14730	COG0768	penicillin binding
I0K03_RS14760	COG1984	allophanate hydrolase subunit 2
I0K03_RS14765	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I0K03_RS14770	COG1414	Transcriptional regulator
I0K03_RS14800	COG0640	Transcriptional regulator
I0K03_RS14810	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS14825	COG3314	Sporulation integral membrane protein YlbJ
I0K03_RS14855	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I0K03_RS14875	COG0574	Belongs to the PEP-utilizing enzyme family
I0K03_RS14875	COG3848	Pyruvate phosphate dikinase
I0K03_RS14900	COG1876	peptidase activity
I0K03_RS14905	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS14910	COG2267	carboxylic ester hydrolase activity
I0K03_RS14915	COG1335	isochorismatase
I0K03_RS14935	COG0583	DNA-binding transcription factor activity
I0K03_RS14945	COG0598	Magnesium transport protein CorA
I0K03_RS14985	COG0415	Belongs to the DNA photolyase family
I0K03_RS14990	COG0288	reversible hydration of carbon dioxide
I0K03_RS15000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K03_RS15005	COG5609	conserved protein (DUF2294)
I0K03_RS15030	COG0697	spore germination
I0K03_RS15040	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K03_RS15070	COG0798	PFAM Bile acid sodium symporter
I0K03_RS15075	COG0346	lactoylglutathione lyase activity
I0K03_RS15080	COG0640	Transcriptional regulator
I0K03_RS15110	COG1309	transcriptional regulator
I0K03_RS15115	COG2186	Transcriptional regulator
I0K03_RS15130	COG0814	amino acid
I0K03_RS15135	COG0697	spore germination
I0K03_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS15150	COG1522	sequence-specific DNA binding
I0K03_RS15165	COG0346	lactoylglutathione lyase activity
I0K03_RS15230	COG0384	phenazine biosynthesis protein PhzF
I0K03_RS15235	COG2814	Major facilitator Superfamily
I0K03_RS15240	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I0K03_RS15265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS15270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K03_RS15280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K03_RS15300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I0K03_RS15320	COG0577	efflux transmembrane transporter activity
I0K03_RS15330	COG5002	protein histidine kinase activity
I0K03_RS15330	COG3850	Histidine kinase
I0K03_RS15340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS15350	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K03_RS15370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0K03_RS15440	COG5444	nuclease activity
I0K03_RS15475	COG1876	peptidase activity
I0K03_RS15480	COG2843	Capsule synthesis protein
I0K03_RS15490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K03_RS15495	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS15505	COG0534	Mate efflux family protein
I0K03_RS15510	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS15515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K03_RS15530	COG0477	Major facilitator Superfamily
I0K03_RS15545	COG1846	Transcriptional regulator
I0K03_RS15550	COG2814	Major facilitator Superfamily
I0K03_RS15570	COG1136	(ABC) transporter
I0K03_RS15595	COG2031	fatty acid transporter
I0K03_RS15605	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K03_RS15660	COG1288	antiporter activity
I0K03_RS15665	COG2356	endonuclease I
I0K03_RS15675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K03_RS15680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0K03_RS15700	COG1733	regulation of RNA biosynthetic process
I0K03_RS15705	COG0778	Nitroreductase
I0K03_RS15740	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS15750	COG1131	(ABC) transporter
I0K03_RS15775	COG1011	Hydrolase
I0K03_RS15785	COG2365	Tyrosine phosphatase family
I0K03_RS15810	COG0346	lactoylglutathione lyase activity
I0K03_RS15815	COG1940	carbohydrate kinase activity
I0K03_RS15820	COG0738	Major facilitator superfamily
I0K03_RS15825	COG0110	maltose O-acetyltransferase activity
I0K03_RS15840	COG0628	permease
I0K03_RS15870	COG0477	Major facilitator Superfamily
I0K03_RS15890	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I0K03_RS15900	COG1253	flavin adenine dinucleotide binding
I0K03_RS15905	COG0789	Transcriptional regulator
I0K03_RS15940	COG0697	spore germination
I0K03_RS15945	COG1357	PFAM Pentapeptide repeats (8 copies)
I0K03_RS15950	COG3813	Protein conserved in bacteria
I0K03_RS15955	COG2706	6-phosphogluconolactonase activity
I0K03_RS15960	COG1070	Carbohydrate kinase
I0K03_RS15975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I0K03_RS15980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I0K03_RS15985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K03_RS15990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K03_RS15995	COG0604	alcohol dehydrogenase
I0K03_RS16000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K03_RS16015	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS16030	COG0840	transmembrane signaling receptor activity
I0K03_RS16040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K03_RS16040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K03_RS16045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0K03_RS16045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I0K03_RS16050	COG1733	regulation of RNA biosynthetic process
I0K03_RS16065	COG0656	L-ascorbic acid biosynthetic process
I0K03_RS16070	COG2814	Major facilitator Superfamily
I0K03_RS16090	COG1846	Transcriptional regulator
I0K03_RS16100	COG2824	Alkylphosphonate utilization operon protein PhnA
I0K03_RS16105	COG0659	secondary active sulfate transmembrane transporter activity
I0K03_RS16120	COG0814	amino acid
I0K03_RS16125	COG3655	Transcriptional regulator
I0K03_RS16155	COG1393	Belongs to the ArsC family
I0K03_RS16160	COG1733	regulation of RNA biosynthetic process
I0K03_RS16165	COG2188	Transcriptional regulator
I0K03_RS16170	COG0673	inositol 2-dehydrogenase activity
I0K03_RS16175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0K03_RS16195	COG1733	regulation of RNA biosynthetic process
I0K03_RS16220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS16245	COG0384	phenazine biosynthesis protein PhzF
I0K03_RS16265	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS16270	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K03_RS16275	COG1733	regulation of RNA biosynthetic process
I0K03_RS16300	COG1191	sigma factor activity
I0K03_RS16310	COG1280	lysine exporter protein (LysE YggA)
I0K03_RS16355	COG1151	hydroxylamine reductase activity
I0K03_RS16400	COG2072	flavoprotein involved in K transport
I0K03_RS16435	COG0604	alcohol dehydrogenase
I0K03_RS16440	COG1113	amino acid transport
I0K03_RS16445	COG0456	acetyltransferase
I0K03_RS16450	COG2814	Major facilitator Superfamily
I0K03_RS16500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K03_RS16505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K03_RS16515	COG1247	-acetyltransferase
I0K03_RS16520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS16525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS16530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS16535	COG3739	integral membrane protein
I0K03_RS16565	COG0583	DNA-binding transcription factor activity
I0K03_RS16585	COG1193	negative regulation of DNA recombination
I0K03_RS16595	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I0K03_RS16600	COG1164	Oligoendopeptidase f
I0K03_RS16625	COG3781	membrane
I0K03_RS16640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K03_RS16670	COG0584	glycerophosphoryl diester phosphodiesterase
I0K03_RS16680	COG0640	Transcriptional regulator
I0K03_RS16685	COG0604	alcohol dehydrogenase
I0K03_RS16695	COG0457	Tetratricopeptide repeat
I0K03_RS16705	COG2808	Putative FMN-binding domain
I0K03_RS16710	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K03_RS16725	COG0277	FAD linked oxidase domain protein
I0K03_RS16740	COG3858	chitin binding
I0K03_RS16750	COG5001	Diguanylate cyclase
I0K03_RS16750	COG3300	MHYT domain
I0K03_RS16760	COG1876	peptidase activity
I0K03_RS16795	COG3852	Histidine kinase
I0K03_RS16805	COG1285	pathogenesis
I0K03_RS16815	COG2514	catechol 2,3-dioxygenase activity
I0K03_RS16820	COG2720	vancomycin resistance protein
I0K03_RS16855	COG0716	FMN binding
I0K03_RS16885	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS16895	COG0165	Argininosuccinate lyase
I0K03_RS16910	COG4145	pantothenate transmembrane transporter activity
I0K03_RS16915	COG3924	membrane
I0K03_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS16935	COG1657	PFAM Prenyltransferase squalene oxidase
I0K03_RS16940	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I0K03_RS16945	COG2962	Rard protein
I0K03_RS16950	COG3326	Membrane
I0K03_RS16965	COG0489	protein tyrosine kinase activity
I0K03_RS16975	COG0314	molybdopterin synthase activity
I0K03_RS16980	COG0303	'Molybdopterin
I0K03_RS16985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K03_RS16990	COG2116	formate transmembrane transporter activity
I0K03_RS17000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K03_RS17005	COG5609	conserved protein (DUF2294)
I0K03_RS17010	COG2427	Protein of unknown function (DUF1641)
I0K03_RS17015	COG3383	formate dehydrogenase (NAD+) activity
I0K03_RS17020	COG0697	spore germination
I0K03_RS17035	COG0531	amino acid
I0K03_RS17070	COG2226	methyltransferase
I0K03_RS17075	COG4166	transmembrane transport
I0K03_RS17080	COG4166	transmembrane transport
I0K03_RS17085	COG4166	transmembrane transport
I0K03_RS17090	COG1301	dicarboxylic acid transport
I0K03_RS17095	COG1316	TRANSCRIPTIONal
I0K03_RS17105	COG1595	DNA-templated transcription, initiation
I0K03_RS17115	COG1131	(ABC) transporter
I0K03_RS17125	COG0673	inositol 2-dehydrogenase activity
I0K03_RS17130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K03_RS17135	COG0187	DNA topoisomerase II activity
I0K03_RS17140	COG1832	CoA-binding protein
I0K03_RS17145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K03_RS17150	COG0745	RESPONSE REGULATOR receiver
I0K03_RS17160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I0K03_RS17160	COG1328	CTP reductase activity
I0K03_RS17170	COG4841	protein insertion into membrane
I0K03_RS17175	COG0824	Thioesterase
I0K03_RS17200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K03_RS17210	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I0K03_RS17215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0K03_RS17245	COG2211	Major facilitator Superfamily
I0K03_RS17255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0K03_RS17270	COG0183	Belongs to the thiolase family
I0K03_RS17275	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS17280	COG1268	BioY protein
I0K03_RS17285	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS17290	COG1396	sequence-specific DNA binding
I0K03_RS17330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS17340	COG5002	protein histidine kinase activity
I0K03_RS17345	COG0400	carboxylic ester hydrolase activity
I0K03_RS17350	COG0346	lactoylglutathione lyase activity
I0K03_RS17355	COG0069	glutamate synthase activity
I0K03_RS17360	COG1902	pentaerythritol trinitrate reductase activity
I0K03_RS17365	COG1329	Transcriptional regulator
I0K03_RS17370	COG0010	Belongs to the arginase family
I0K03_RS17420	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K03_RS17425	COG0785	Cytochrome C biogenesis protein
I0K03_RS17435	COG1473	amidohydrolase
I0K03_RS17445	COG1131	(ABC) transporter
I0K03_RS17460	COG0583	DNA-binding transcription factor activity
I0K03_RS17470	COG1346	cytolysis
I0K03_RS17485	COG0730	response to heat
I0K03_RS17510	COG1132	(ABC) transporter
I0K03_RS17515	COG1132	(ABC) transporter
I0K03_RS17520	COG3763	UPF0154 protein
I0K03_RS17540	COG3639	organic phosphonate transmembrane transporter activity
I0K03_RS17550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS17555	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS17565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I0K03_RS17585	COG1695	Transcriptional regulator
I0K03_RS17590	COG1132	(ABC) transporter
I0K03_RS17620	COG0367	asparagine synthase
I0K03_RS17625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0K03_RS17635	COG1181	Belongs to the D-alanine--D-alanine ligase family
I0K03_RS17640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K03_RS17645	COG5434	Belongs to the glycosyl hydrolase 28 family
I0K03_RS17645	COG3420	alginic acid biosynthetic process
I0K03_RS17670	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS17680	COG0463	Glycosyl transferase, family 2
I0K03_RS17680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I0K03_RS17685	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS17690	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS17695	COG1086	Polysaccharide biosynthesis protein
I0K03_RS17700	COG0489	protein tyrosine kinase activity
I0K03_RS17710	COG0174	glutamine synthetase
I0K03_RS17715	COG0789	Transcriptional regulator
I0K03_RS17720	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I0K03_RS17725	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K03_RS17730	COG2860	membrane
I0K03_RS17740	COG0464	growth
I0K03_RS17785	COG3584	3D domain protein
I0K03_RS17785	COG1388	LysM domain
I0K03_RS17790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K03_RS17790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K03_RS17790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K03_RS17795	COG1105	Belongs to the carbohydrate kinase PfkB family
I0K03_RS17800	COG1349	DNA-binding transcription factor activity
I0K03_RS17805	COG1979	alcohol dehydrogenase
I0K03_RS17810	COG2322	membrane
I0K03_RS17820	COG1113	amino acid transport
I0K03_RS17830	COG1473	amidohydrolase
I0K03_RS17835	COG1408	metallophosphoesterase
I0K03_RS17855	COG2217	Heavy metal translocating P-type atpase
I0K03_RS17860	COG2608	mercury ion transmembrane transporter activity
I0K03_RS17865	COG1937	Protein conserved in bacteria
I0K03_RS17885	COG2819	hydrolase of the alpha beta superfamily
I0K03_RS17890	COG1120	ATPase activity
I0K03_RS17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS17900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS17905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS17910	COG0708	Exodeoxyribonuclease III
I0K03_RS17915	COG2169	Transcriptional regulator
I0K03_RS17920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K03_RS17925	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K03_RS17935	COG2364	Membrane
I0K03_RS17950	COG2267	carboxylic ester hydrolase activity
I0K03_RS17955	COG3300	MHYT domain
I0K03_RS17955	COG5001	Diguanylate cyclase
I0K03_RS17995	COG1346	cytolysis
I0K03_RS18005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K03_RS18010	COG0596	Alpha beta hydrolase
I0K03_RS18010	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K03_RS18015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K03_RS18025	COG2188	Transcriptional regulator
I0K03_RS18030	COG2723	6-phospho-beta-galactosidase activity
I0K03_RS18040	COG1404	Belongs to the peptidase S8 family
I0K03_RS18045	COG3773	Cell wall hydrolase
I0K03_RS18055	COG1368	sulfuric ester hydrolase activity
I0K03_RS18085	COG4550	Control of competence regulator ComK, YlbF/YmcA
I0K03_RS18095	COG1013	pyruvate-flavodoxin oxidoreductase activity
I0K03_RS18100	COG0674	pyruvate-flavodoxin oxidoreductase activity
I0K03_RS18100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I0K03_RS18110	COG2359	stage V sporulation protein S
I0K03_RS18115	COG1692	metallophosphoesterase
I0K03_RS18135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0K03_RS18140	COG1426	Protein conserved in bacteria
I0K03_RS18155	COG0300	oxidoreductase activity
I0K03_RS18160	COG0612	Peptidase, M16
I0K03_RS18165	COG0612	Peptidase, M16
I0K03_RS18170	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS18175	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0K03_RS18180	COG3845	ABC transporter
I0K03_RS18185	COG1744	ABC transporter substrate-binding protein PnrA-like
I0K03_RS18190	COG2188	Transcriptional regulator
I0K03_RS18195	COG1674	ftsk spoiiie
I0K03_RS18205	COG0740	serine-type endopeptidase activity
I0K03_RS18210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K03_RS18220	COG0527	aspartate kinase activity
I0K03_RS18225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K03_RS18230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K03_RS18330	COG0740	serine-type endopeptidase activity
I0K03_RS18380	COG0582	viral genome integration into host DNA
I0K03_RS18425	COG0305	Participates in initiation and elongation during chromosome replication
I0K03_RS18460	COG1396	sequence-specific DNA binding
I0K03_RS18485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K03_RS18490	COG1873	PFAM PRC-barrel domain
I0K03_RS18495	COG0612	Peptidase, M16
I0K03_RS18500	COG0726	polysaccharide deacetylase
I0K03_RS18515	COG0196	riboflavin kinase activity
I0K03_RS18525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I0K03_RS18530	COG1550	Protein conserved in bacteria
I0K03_RS18540	COG1358	cellular component organization or biogenesis
I0K03_RS18545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I0K03_RS18550	COG0195	Participates in both transcription termination and antitermination
I0K03_RS18570	COG0750	zinc metalloprotease
I0K03_RS18580	COG4589	Belongs to the CDS family
I0K03_RS18595	COG0528	UMP kinase activity
I0K03_RS18600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I0K03_RS18625	COG4974	Belongs to the 'phage' integrase family
I0K03_RS18635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K03_RS18640	COG0758	DNA mediated transformation
I0K03_RS18645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0K03_RS18670	COG0335	large ribosomal subunit rRNA binding
I0K03_RS18685	COG1837	Belongs to the UPF0109 family
I0K03_RS18695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0K03_RS18705	COG0552	protein localization to endoplasmic reticulum
I0K03_RS18710	COG1196	nuclear chromosome segregation
I0K03_RS18720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K03_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS18730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I0K03_RS18745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0K03_RS18750	COG1461	Dihydroxyacetone kinase
I0K03_RS18755	COG1302	Protein conserved in bacteria
I0K03_RS18770	COG1564	THIamine pyrophosphokinase
I0K03_RS18775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I0K03_RS18780	COG1162	GTPase activity
I0K03_RS18785	COG2815	serine threonine protein kinase
I0K03_RS18785	COG0515	serine threonine protein kinase
I0K03_RS18790	COG0631	protein serine/threonine phosphatase activity
I0K03_RS18800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0K03_RS18800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I0K03_RS18805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0K03_RS18815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I0K03_RS18820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K03_RS18840	COG1561	YicC-like family, N-terminal region
I0K03_RS18845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I0K03_RS18855	COG0006	proline dipeptidase activity
I0K03_RS18935	COG0564	pseudouridine synthase activity
I0K03_RS18955	COG3599	regulation of cell shape
I0K03_RS18960	COG2302	S4 RNA-binding domain
I0K03_RS18965	COG0762	integral membrane protein
I0K03_RS18975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I0K03_RS18985	COG1873	PFAM PRC-barrel domain
I0K03_RS18990	COG1191	sigma factor activity
I0K03_RS18995	COG1191	sigma factor activity
I0K03_RS19005	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0K03_RS19010	COG0849	cell division
I0K03_RS19015	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0K03_RS19030	COG0772	Belongs to the SEDS family
I0K03_RS19050	COG0768	penicillin binding
I0K03_RS19055	COG0768	penicillin binding
I0K03_RS19075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K03_RS19090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0K03_RS19095	COG1399	metal-binding, possibly nucleic acid-binding protein
I0K03_RS19105	COG3480	Lon protease (S16) C-terminal proteolytic domain
I0K03_RS19110	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K03_RS19115	COG3314	Sporulation integral membrane protein YlbJ
I0K03_RS19125	COG0742	ribosomal rna small subunit methyltransferase
I0K03_RS19140	COG3679	Belongs to the UPF0342 family
I0K03_RS19145	COG0406	alpha-ribazole phosphatase activity
I0K03_RS19160	COG2340	Cysteine-rich secretory protein family
I0K03_RS19175	COG3336	cytochrome c oxidase
I0K03_RS19210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I0K03_RS19215	COG0772	Belongs to the SEDS family
I0K03_RS19225	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I0K03_RS19230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I0K03_RS19240	COG4896	Protein conserved in bacteria
I0K03_RS19255	COG1217	gtp-binding protein TYPA
I0K03_RS19265	COG0483	inositol monophosphate 1-phosphatase activity
I0K03_RS19285	COG1982	Orn Lys Arg decarboxylase major
I0K03_RS19345	COG0022	dehydrogenase e1 component
I0K03_RS19350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K03_RS19360	COG0242	peptide deformylase activity
I0K03_RS19365	COG0561	phosphatase activity
I0K03_RS19370	COG5503	Protein of unknown function (DUF1447)
I0K03_RS19375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K03_RS19380	COG0569	domain protein
I0K03_RS19395	COG2171	N-acyltransferase activity
I0K03_RS19400	COG0583	DNA-binding transcription factor activity
I0K03_RS19405	COG0517	IMP dehydrogenase activity
I0K03_RS19415	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I0K03_RS19425	COG4703	Protein of unknown function (DUF1797)
I0K03_RS19445	COG2200	EAL domain
I0K03_RS19450	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS19455	COG1408	metallophosphoesterase
I0K03_RS19465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I0K03_RS19500	COG2814	Major facilitator Superfamily
I0K03_RS19520	COG3209	COG3209 Rhs family protein
I0K03_RS19530	COG2205	protein histidine kinase activity
I0K03_RS19540	COG0436	Aminotransferase
I0K03_RS19545	COG1609	Transcriptional regulator
I0K03_RS19550	COG3833	ABC-type maltose transport systems, permease component
I0K03_RS19555	COG1175	transmembrane transport
I0K03_RS19560	COG2182	Extracellular solute-binding protein
I0K03_RS19570	COG0366	Alpha amylase catalytic
I0K03_RS19575	COG3842	ATPase activity
I0K03_RS19615	COG0183	Belongs to the thiolase family
I0K03_RS19655	COG1695	Transcriptional regulator
I0K03_RS19660	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS19675	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I0K03_RS19680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0K03_RS19685	COG0436	Aminotransferase
I0K03_RS19720	COG2084	Dehydrogenase
I0K03_RS19730	COG2199	diguanylate cyclase activity
I0K03_RS19735	COG0778	Nitroreductase
I0K03_RS19760	COG2190	(PTS) system
I0K03_RS19760	COG1263	PTS System
I0K03_RS19760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K03_RS19765	COG3711	transcriptional antiterminator
I0K03_RS19775	COG2188	Transcriptional regulator
I0K03_RS19785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0K03_RS19810	COG1547	Domain of unknown function (DUF309)
I0K03_RS19815	COG0456	acetyltransferase
I0K03_RS19820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0K03_RS19825	COG4086	secreted protein
I0K03_RS19830	COG0561	phosphatase activity
I0K03_RS19835	COG0697	spore germination
I0K03_RS19850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K03_RS19875	COG0733	neurotransmitter:sodium symporter activity
I0K03_RS19895	COG1686	Belongs to the peptidase S11 family
I0K03_RS19900	COG1725	Transcriptional regulator
I0K03_RS19905	COG1131	(ABC) transporter
I0K03_RS19925	COG1846	Transcriptional regulator
I0K03_RS19940	COG0598	Magnesium transport protein CorA
I0K03_RS19965	COG4974	Belongs to the 'phage' integrase family
I0K03_RS19975	COG0735	belongs to the Fur family
I0K03_RS19980	COG1300	Membrane
I0K03_RS20000	COG0667	Aldo Keto reductase
I0K03_RS20005	COG0656	L-ascorbic acid biosynthetic process
I0K03_RS20010	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K03_RS20010	COG0456	acetyltransferase
I0K03_RS20020	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS20020	COG4085	toxin activity
I0K03_RS20020	COG1525	nuclease
I0K03_RS20030	COG0596	Alpha beta hydrolase
I0K03_RS20035	COG2056	Na+-H+ antiporter family
I0K03_RS20040	COG1609	Transcriptional regulator
I0K03_RS20045	COG0456	acetyltransferase
I0K03_RS20050	COG1073	alpha beta
I0K03_RS20065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K03_RS20065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K03_RS20070	COG0307	riboflavin synthase, alpha
I0K03_RS20095	COG4106	trans-aconitate 2-methyltransferase activity
I0K03_RS20100	COG1073	alpha beta
I0K03_RS20100	COG2226	methyltransferase
I0K03_RS20115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K03_RS20125	COG1757	Na H antiporter
I0K03_RS20130	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS20140	COG1522	sequence-specific DNA binding
I0K03_RS20175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I0K03_RS20185	COG0300	oxidoreductase activity
I0K03_RS20190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS20195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K03_RS20200	COG1760	l-serine dehydratase
I0K03_RS20205	COG1760	l-serine dehydratase
I0K03_RS20230	COG1285	pathogenesis
I0K03_RS20245	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K03_RS20250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS20265	COG1376	ErfK ybiS ycfS ynhG family protein
I0K03_RS20270	COG4129	membrane
I0K03_RS20275	COG1126	abc transporter atp-binding protein
I0K03_RS20280	COG0765	amino acid transport
I0K03_RS20285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K03_RS20300	COG2816	NAD+ diphosphatase activity
I0K03_RS20305	COG2323	membrane
I0K03_RS20310	COG0772	Belongs to the SEDS family
I0K03_RS20315	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K03_RS20320	COG0022	dehydrogenase e1 component
I0K03_RS20325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K03_RS20330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K03_RS20345	COG0280	phosphate acetyltransferase
I0K03_RS20350	COG3290	protein histidine kinase activity
I0K03_RS20350	COG3829	transcription factor binding
I0K03_RS20360	COG0584	glycerophosphoryl diester phosphodiesterase
I0K03_RS20365	COG3093	addiction module antidote protein HigA
I0K03_RS20370	COG1215	transferase activity, transferring glycosyl groups
I0K03_RS20380	COG0745	RESPONSE REGULATOR receiver
I0K03_RS20385	COG0750	zinc metalloprotease
I0K03_RS20390	COG0497	DNA recombination
I0K03_RS20400	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I0K03_RS20410	COG0142	geranyltranstransferase activity
I0K03_RS20430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0K03_RS20435	COG1302	Protein conserved in bacteria
I0K03_RS20440	COG0439	Biotin carboxylase
I0K03_RS20445	COG0511	ligase activity, forming carbon-carbon bonds
I0K03_RS20490	COG3854	ATPases associated with a variety of cellular activities
I0K03_RS20515	COG0006	proline dipeptidase activity
I0K03_RS20530	COG3872	metal-dependent enzyme
I0K03_RS20540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0K03_RS20570	COG0095	Lipoate-protein ligase
I0K03_RS20575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS20585	COG1609	Transcriptional regulator
I0K03_RS20595	COG2076	Multidrug Resistance protein
I0K03_RS20600	COG2076	Multidrug Resistance protein
I0K03_RS20625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I0K03_RS20635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I0K03_RS20640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K03_RS20695	COG4970	Tfp pilus assembly protein FimT
I0K03_RS20705	COG1459	type II secretion system
I0K03_RS20710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I0K03_RS20765	COG0646	methionine synthase
I0K03_RS20765	COG1410	methionine synthase
I0K03_RS20770	COG0646	methionine synthase
I0K03_RS20770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I0K03_RS20775	COG0626	cystathionine gamma-synthase activity
I0K03_RS20780	COG0626	cystathionine gamma-synthase activity
I0K03_RS20805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS20815	COG1940	carbohydrate kinase activity
I0K03_RS20820	COG4483	Protein conserved in bacteria
I0K03_RS20825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0K03_RS20830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0K03_RS20835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0K03_RS20840	COG0704	Plays a role in the regulation of phosphate uptake
I0K03_RS20850	COG0581	inorganic phosphate transmembrane transporter activity
I0K03_RS20855	COG0573	inorganic phosphate transmembrane transporter activity
I0K03_RS20860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K03_RS20865	COG0768	penicillin binding
I0K03_RS20870	COG0477	Major facilitator Superfamily
I0K03_RS20875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K03_RS20900	COG0735	belongs to the Fur family
I0K03_RS20905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0K03_RS20910	COG1121	(ABC) transporter
I0K03_RS20915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS20945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0K03_RS20950	COG2384	SAM-dependent methyltransferase
I0K03_RS20955	COG2010	Cytochrome c
I0K03_RS20960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0K03_RS20965	COG0358	DNA primase activity
I0K03_RS20970	COG1671	Belongs to the UPF0178 family
I0K03_RS20980	COG0517	IMP dehydrogenase activity
I0K03_RS20995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0K03_RS21000	COG0295	cytidine deaminase activity
I0K03_RS21005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I0K03_RS21010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I0K03_RS21015	COG1480	7TM receptor with intracellular HD hydrolase
I0K03_RS21020	COG1702	phosphate starvation-inducible protein PhoH
I0K03_RS21035	COG1610	YqeY-like protein
I0K03_RS21040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0K03_RS21045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0K03_RS21050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0K03_RS21060	COG0484	heat shock protein binding
I0K03_RS21075	COG1420	regulation of RNA biosynthetic process
I0K03_RS21080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K03_RS21085	COG1733	regulation of RNA biosynthetic process
I0K03_RS21110	COG1466	dna polymerase III delta subunit
I0K03_RS21120	COG2333	competence protein COMEC
I0K03_RS21120	COG0658	competence protein
I0K03_RS21125	COG2131	deaminase
I0K03_RS21130	COG1555	photosystem II stabilization
I0K03_RS21130	COG1596	polysaccharide export
I0K03_RS21135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K03_RS21140	COG2226	methyltransferase
I0K03_RS21145	COG0799	negative regulation of ribosome biogenesis
I0K03_RS21150	COG1713	HD superfamily hydrolase involved in NAD metabolism
I0K03_RS21155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I0K03_RS21160	COG1534	Rna-binding protein
I0K03_RS21170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I0K03_RS21175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I0K03_RS21210	COG0778	Nitroreductase
I0K03_RS21215	COG2357	RelA SpoT domain protein
I0K03_RS21225	COG1785	Belongs to the alkaline phosphatase family
I0K03_RS21235	COG2267	carboxylic ester hydrolase activity
I0K03_RS21270	COG1404	Belongs to the peptidase S8 family
I0K03_RS21275	COG3186	Phenylalanine-4-hydroxylase
I0K03_RS21285	COG2514	catechol 2,3-dioxygenase activity
I0K03_RS21290	COG2259	Doxx family
I0K03_RS21330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS21340	COG1454	alcohol dehydrogenase
I0K03_RS21340	COG1012	belongs to the aldehyde dehydrogenase family
I0K03_RS21345	COG0626	cystathionine gamma-synthase activity
I0K03_RS21350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K03_RS21375	COG0768	penicillin binding
I0K03_RS21390	COG0826	peptidase U32
I0K03_RS21395	COG0826	peptidase U32
I0K03_RS21400	COG4122	O-methyltransferase activity
I0K03_RS21405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0K03_RS21420	COG4472	Bacterial protein of unknown function (DUF965)
I0K03_RS21435	COG0628	permease
I0K03_RS21455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0K03_RS21470	COG1104	cysteine desulfurase activity
I0K03_RS21475	COG1959	2 iron, 2 sulfur cluster binding
I0K03_RS21480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0K03_RS21490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I0K03_RS21525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0K03_RS21535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I0K03_RS21535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0K03_RS21540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K03_RS21545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K03_RS21545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K03_RS21555	COG2244	polysaccharide biosynthetic process
I0K03_RS21560	COG2323	membrane
I0K03_RS21570	COG1862	Preprotein translocase
I0K03_RS21575	COG0343	queuine tRNA-ribosyltransferase activity
I0K03_RS21590	COG2255	four-way junction helicase activity
I0K03_RS21595	COG0632	four-way junction helicase activity
I0K03_RS21600	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I0K03_RS21630	COG0157	Belongs to the NadC ModD family
I0K03_RS21635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I0K03_RS21640	COG1104	cysteine desulfurase activity
I0K03_RS21645	COG1827	regulation of RNA biosynthetic process
I0K03_RS21650	COG2258	MOSC domain
I0K03_RS21655	COG0077	Prephenate dehydratase
I0K03_RS21660	COG0577	efflux transmembrane transporter activity
I0K03_RS21665	COG0577	efflux transmembrane transporter activity
I0K03_RS21670	COG1136	(ABC) transporter
I0K03_RS21675	COG5002	protein histidine kinase activity
I0K03_RS21680	COG0745	RESPONSE REGULATOR receiver
I0K03_RS21690	COG3290	protein histidine kinase activity
I0K03_RS21700	COG2868	ribosomal protein
I0K03_RS21710	COG1530	ribonuclease E activity
I0K03_RS21715	COG1994	Peptidase M50
I0K03_RS21720	COG0739	heme binding
I0K03_RS21725	COG2894	cell division
I0K03_RS21745	COG1077	Cell shape determining protein MreB Mrl
I0K03_RS21765	COG0285	dihydrofolate synthase activity
I0K03_RS21780	COG1388	LysM domain
I0K03_RS21790	COG0113	porphobilinogen synthase activity
I0K03_RS21795	COG1587	Uroporphyrinogen-III synthase
I0K03_RS21805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K03_RS21815	COG1846	Transcriptional regulator
I0K03_RS21820	COG1764	response to oxidative stress
I0K03_RS21835	COG0470	DNA polymerase III
I0K03_RS21835	COG1067	ATP-dependent peptidase activity
I0K03_RS21880	COG0622	Phosphoesterase
I0K03_RS21895	COG5401	PFAM Sporulation and spore germination
I0K03_RS21915	COG1309	transcriptional regulator
I0K03_RS21925	COG2197	response regulator
I0K03_RS21930	COG2233	PERMEase
I0K03_RS21935	COG0402	S-adenosylhomocysteine deaminase activity
I0K03_RS21940	COG1983	PspC domain protein
I0K03_RS21945	COG1396	sequence-specific DNA binding
I0K03_RS21950	COG0697	spore germination
I0K03_RS21960	COG1959	2 iron, 2 sulfur cluster binding
I0K03_RS21965	COG1668	transmembrane transport
I0K03_RS21970	COG4152	abc transporter atp-binding protein
I0K03_RS21975	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I0K03_RS21980	COG1360	Flagellar Motor Protein
I0K03_RS21985	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K03_RS21990	COG1876	peptidase activity
I0K03_RS21995	COG0824	Thioesterase
I0K03_RS22000	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I0K03_RS22005	COG1053	succinate dehydrogenase
I0K03_RS22010	COG2009	succinate dehydrogenase
I0K03_RS22015	COG1719	4-vinyl reductase, 4VR
I0K03_RS22020	COG0322	excinuclease ABC activity
I0K03_RS22025	COG3118	belongs to the thioredoxin family
I0K03_RS22030	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0K03_RS22035	COG2086	electron transfer activity
I0K03_RS22040	COG1024	Enoyl-CoA hydratase
I0K03_RS22045	COG1309	transcriptional regulator
I0K03_RS22050	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS22080	COG2318	DinB family
I0K03_RS22110	COG1131	(ABC) transporter
I0K03_RS22115	COG2205	protein histidine kinase activity
I0K03_RS22120	COG0745	RESPONSE REGULATOR receiver
I0K03_RS22130	COG4895	conserved protein (DUF2196)
I0K03_RS22135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I0K03_RS22145	COG4509	Sortase family
I0K03_RS22150	COG1120	ATPase activity
I0K03_RS22165	COG5386	Cell surface protein
I0K03_RS22175	COG5386	Cell surface protein
I0K03_RS22180	COG1114	Component of the transport system for branched-chain amino acids
I0K03_RS22185	COG1187	pseudouridine synthase activity
I0K03_RS22195	COG1796	DNA polymerase
I0K03_RS22195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I0K03_RS22200	COG1286	toxin biosynthetic process
I0K03_RS22205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I0K03_RS22240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K03_RS22250	COG1418	mRNA catabolic process
I0K03_RS22270	COG2814	Major facilitator Superfamily
I0K03_RS22275	COG1566	PFAM secretion protein HlyD family protein
I0K03_RS22280	COG1309	transcriptional regulator
I0K03_RS22285	COG1363	Peptidase, m42
I0K03_RS22310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K03_RS22320	COG1484	DNA-dependent DNA replication
I0K03_RS22325	COG3611	Membrane attachment protein
I0K03_RS22335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I0K03_RS22340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K03_RS22345	COG0237	dephospho-CoA kinase activity
I0K03_RS22350	COG1971	Probably functions as a manganese efflux pump
I0K03_RS22360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K03_RS22360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K03_RS22365	COG5002	protein histidine kinase activity
I0K03_RS22370	COG0745	RESPONSE REGULATOR receiver
I0K03_RS22390	COG0538	isocitrate dehydrogenase activity
I0K03_RS22395	COG0372	Belongs to the citrate synthase family
I0K03_RS22405	COG0628	permease
I0K03_RS22410	COG3030	protein affecting phage T7 exclusion by the F plasmid
I0K03_RS22435	COG1725	Transcriptional regulator
I0K03_RS22440	COG0281	malic enzyme
I0K03_RS22445	COG0587	DNA-directed DNA polymerase activity
I0K03_RS22460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I0K03_RS22475	COG4109	DRTGG domain
I0K03_RS22490	COG0006	proline dipeptidase activity
I0K03_RS22530	COG0662	Cupin 2, conserved barrel domain protein
I0K03_RS22545	COG1028	Short-chain dehydrogenase reductase Sdr
I0K03_RS22550	COG0589	response to stress
I0K03_RS22555	COG0346	lactoylglutathione lyase activity
I0K03_RS22595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS22620	COG0827	DNA restriction-modification system
I0K03_RS22625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I0K03_RS22630	COG3874	Sporulation protein YtfJ
I0K03_RS22645	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I0K03_RS22655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K03_RS22670	COG1104	cysteine desulfurase activity
I0K03_RS22675	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I0K03_RS22680	COG0583	DNA-binding transcription factor activity
I0K03_RS22685	COG0697	spore germination
I0K03_RS22690	COG1309	transcriptional regulator
I0K03_RS22695	COG1956	GAF domain-containing protein
I0K03_RS22700	COG0626	cystathionine gamma-synthase activity
I0K03_RS22735	COG1595	DNA-templated transcription, initiation
I0K03_RS22745	COG0110	maltose O-acetyltransferase activity
I0K03_RS22750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K03_RS22755	COG0454	-acetyltransferase
I0K03_RS22760	COG0517	IMP dehydrogenase activity
I0K03_RS22765	COG0123	including yeast histone deacetylase and acetoin utilization protein
I0K03_RS22780	COG0745	RESPONSE REGULATOR receiver
I0K03_RS22785	COG5002	protein histidine kinase activity
I0K03_RS22790	COG0666	response to abiotic stimulus
I0K03_RS22820	COG1609	Transcriptional regulator
I0K03_RS22830	COG4851	CamS sex pheromone cAM373 precursor
I0K03_RS22835	COG3118	belongs to the thioredoxin family
I0K03_RS22845	COG2309	aminopeptidase activity
I0K03_RS22870	COG0697	spore germination
I0K03_RS22875	COG0789	Transcriptional regulator
I0K03_RS22890	COG1674	ftsk spoiiie
I0K03_RS22895	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K03_RS22895	COG1388	LysM domain
I0K03_RS22905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K03_RS22910	COG4848	Belongs to the UPF0354 family
I0K03_RS22915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K03_RS22920	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I0K03_RS22925	COG1363	Peptidase, m42
I0K03_RS22950	COG0510	thiamine kinase activity
I0K03_RS22955	COG1523	belongs to the glycosyl hydrolase 13 family
I0K03_RS22965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K03_RS22970	COG1349	DNA-binding transcription factor activity
I0K03_RS22975	COG1187	pseudouridine synthase activity
I0K03_RS22980	COG2244	polysaccharide biosynthetic process
I0K03_RS22985	COG2081	HI0933 family
I0K03_RS22990	COG2814	Major facilitator Superfamily
I0K03_RS23000	COG3832	glyoxalase III activity
I0K03_RS23020	COG1329	Transcriptional regulator
I0K03_RS23045	COG0314	molybdopterin synthase activity
I0K03_RS23050	COG1763	Mo-molybdopterin cofactor biosynthetic process
I0K03_RS23055	COG0303	'Molybdopterin
I0K03_RS23065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K03_RS23070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K03_RS23090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K03_RS23100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0K03_RS23145	COG2814	Major facilitator Superfamily
I0K03_RS23150	COG0475	glutathione-regulated potassium exporter activity
I0K03_RS23155	COG0490	domain, Protein
I0K03_RS23160	COG0582	viral genome integration into host DNA
I0K03_RS23175	COG1136	(ABC) transporter
I0K03_RS23195	COG1242	4 iron, 4 sulfur cluster binding
I0K03_RS23200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I0K03_RS23205	COG1794	racemase activity, acting on amino acids and derivatives
I0K03_RS23225	COG2267	carboxylic ester hydrolase activity
I0K03_RS23230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I0K03_RS23235	COG0671	phosphoesterase, PA-phosphatase related
I0K03_RS23240	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS23300	COG3852	Histidine kinase
I0K03_RS23305	COG3852	Histidine kinase
I0K03_RS23315	COG2267	carboxylic ester hydrolase activity
I0K03_RS23320	COG1368	sulfuric ester hydrolase activity
I0K03_RS23335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K03_RS23340	COG1116	anion transmembrane transporter activity
I0K03_RS23345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K03_RS23370	COG0494	nUDIX hydrolase
I0K03_RS23395	COG1854	S-ribosylhomocysteine lyase activity
I0K03_RS23405	COG0288	reversible hydration of carbon dioxide
I0K03_RS23410	COG1271	oxidase subunit
I0K03_RS23415	COG1294	oxidase, subunit
I0K03_RS23430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS23455	COG1842	Phage shock protein A
I0K03_RS23485	COG5002	protein histidine kinase activity
I0K03_RS23490	COG0745	RESPONSE REGULATOR receiver
I0K03_RS23515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K03_RS23520	COG1597	lipid kinase activity
I0K03_RS23530	COG0577	efflux transmembrane transporter activity
I0K03_RS23535	COG1136	(ABC) transporter
I0K03_RS23560	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS23565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I0K03_RS23570	COG0577	efflux transmembrane transporter activity
I0K03_RS23575	COG1136	(ABC) transporter
I0K03_RS23580	COG2207	Transcriptional regulator
I0K03_RS23580	COG3708	Transcriptional regulator
I0K03_RS23590	COG1131	(ABC) transporter
I0K03_RS23595	COG5658	integral membrane protein
I0K03_RS23600	COG0640	Transcriptional regulator
I0K03_RS23610	COG1595	DNA-templated transcription, initiation
I0K03_RS23615	COG0745	RESPONSE REGULATOR receiver
I0K03_RS23620	COG2205	protein histidine kinase activity
I0K03_RS23625	COG0577	efflux transmembrane transporter activity
I0K03_RS23630	COG0577	efflux transmembrane transporter activity
I0K03_RS23635	COG1136	(ABC) transporter
I0K03_RS23640	COG0577	efflux transmembrane transporter activity
I0K03_RS23655	COG2188	Transcriptional regulator
I0K03_RS23675	COG3964	amidohydrolase
I0K03_RS23690	COG0745	RESPONSE REGULATOR receiver
I0K03_RS23695	COG4948	Mandelate Racemase Muconate Lactonizing
I0K03_RS23705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I0K03_RS23710	COG0596	Alpha beta hydrolase
I0K03_RS23720	COG1169	isochorismate synthase
I0K03_RS23725	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K03_RS23730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I0K03_RS23735	COG1278	Cold shock
I0K03_RS23755	COG0058	SHG alpha-glucan phosphorylase activity
I0K03_RS23765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I0K03_RS23770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I0K03_RS23895	COG0544	peptidyl-prolyl cis-trans isomerase activity
I0K03_RS23930	COG1285	pathogenesis
I0K03_RS23935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K03_RS23950	COG2155	Conserved Protein
I0K03_RS23955	COG1098	S1 RNA binding domain
I0K03_RS23960	COG0436	Aminotransferase
I0K03_RS23965	COG1522	sequence-specific DNA binding
I0K03_RS23970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K03_RS23975	COG2267	carboxylic ester hydrolase activity
I0K03_RS23985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I0K03_RS24005	COG5018	Exonuclease
I0K03_RS24010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K03_RS24030	COG2050	protein possibly involved in aromatic compounds catabolism
I0K03_RS24040	COG1268	BioY protein
I0K03_RS24045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K03_RS24050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0K03_RS24065	COG3584	3D domain protein
I0K03_RS24080	COG1252	NADH dehydrogenase
I0K03_RS24090	COG3708	Transcriptional regulator
I0K03_RS24105	COG1683	Conserved Protein
I0K03_RS24125	COG0316	Belongs to the HesB IscA family
I0K03_RS24140	COG1252	NADH dehydrogenase
I0K03_RS24155	COG0390	transport system, permease component
I0K03_RS24160	COG2824	Alkylphosphonate utilization operon protein PhnA
I0K03_RS24185	COG4837	Protein of unknown function (DUF1462)
I0K03_RS24190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I0K03_RS24200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K03_RS24205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I0K03_RS24225	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K03_RS24235	COG0647	UMP catabolic process
I0K03_RS24245	COG2445	Protein of unknown function DUF86
I0K03_RS24250	COG1494	fructose-1,6-bisphosphatase
I0K03_RS24270	COG4470	Protein conserved in bacteria
I0K03_RS24280	COG0789	Transcriptional regulator
I0K03_RS24285	COG4377	Putative membrane peptidase family (DUF2324)
I0K03_RS24310	COG0739	heme binding
I0K03_RS24320	COG3377	Domain of unknown function (DUF1805)
I0K03_RS24325	COG0737	Belongs to the 5'-nucleotidase family
I0K03_RS24330	COG0719	Fe-S assembly protein
I0K03_RS24335	COG0822	iron-sulfur transferase activity
I0K03_RS24340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0K03_RS24345	COG0719	Fe-S assembly protein
I0K03_RS24350	COG0396	ATPase activity
I0K03_RS24355	COG1464	Belongs to the NlpA lipoprotein family
I0K03_RS24360	COG1464	Belongs to the NlpA lipoprotein family
I0K03_RS24365	COG2011	ABC-type metal ion transport system permease component
I0K03_RS24380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K03_RS24385	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I0K03_RS24395	COG1393	Belongs to the ArsC family
I0K03_RS24425	COG0039	L-malate dehydrogenase activity
I0K03_RS24445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS24450	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS24455	COG0183	Belongs to the thiolase family
I0K03_RS24460	COG1024	Enoyl-CoA hydratase
I0K03_RS24460	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K03_RS24470	COG1686	Belongs to the peptidase S11 family
I0K03_RS24485	COG0011	TIGRFAM Protein of
I0K03_RS24490	COG0840	transmembrane signaling receptor activity
I0K03_RS24505	COG2814	Major facilitator Superfamily
I0K03_RS24510	COG0531	amino acid
I0K03_RS24530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K03_RS24565	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS24575	COG1376	ErfK ybiS ycfS ynhG family protein
I0K03_RS24580	COG0745	RESPONSE REGULATOR receiver
I0K03_RS24585	COG5002	protein histidine kinase activity
I0K03_RS24605	COG0840	transmembrane signaling receptor activity
I0K03_RS24610	COG0840	transmembrane signaling receptor activity
I0K03_RS24615	COG2151	metal-sulfur cluster biosynthetic enzyme
I0K03_RS24620	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS24640	COG0586	Pfam SNARE associated Golgi protein
I0K03_RS24645	COG0475	glutathione-regulated potassium exporter activity
I0K03_RS24650	COG0490	domain, Protein
I0K03_RS24655	COG1115	amino acid carrier protein
I0K03_RS24660	COG0783	Belongs to the Dps family
I0K03_RS24675	COG1611	Belongs to the LOG family
I0K03_RS24685	COG1528	Iron-storage protein
I0K03_RS24690	COG2311	Membrane
I0K03_RS24695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS24700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS24705	COG1115	amino acid carrier protein
I0K03_RS24710	COG1115	amino acid carrier protein
I0K03_RS24715	COG2910	NAD(P)H-binding
I0K03_RS24730	COG0656	L-ascorbic acid biosynthetic process
I0K03_RS24735	COG2814	Major facilitator Superfamily
I0K03_RS24740	COG1733	regulation of RNA biosynthetic process
I0K03_RS24750	COG1252	NADH dehydrogenase
I0K03_RS24770	COG3290	protein histidine kinase activity
I0K03_RS24770	COG0840	transmembrane signaling receptor activity
I0K03_RS24780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0K03_RS24805	COG0488	(ABC) transporter
I0K03_RS24810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS24825	COG1335	isochorismatase
I0K03_RS24830	COG1522	sequence-specific DNA binding
I0K03_RS24840	COG1522	sequence-specific DNA binding
I0K03_RS24845	COG0288	reversible hydration of carbon dioxide
I0K03_RS24850	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I0K03_RS24855	COG2233	PERMEase
I0K03_RS24900	COG0557	exoribonuclease II activity
I0K03_RS24905	COG1647	Serine aminopeptidase, S33
I0K03_RS24910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K03_RS24915	COG1346	cytolysis
I0K03_RS24950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K03_RS24965	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I0K03_RS25000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K03_RS25015	COG2323	membrane
I0K03_RS25025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K03_RS25035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I0K03_RS25045	COG1051	belongs to the nudix hydrolase family
I0K03_RS25055	COG0492	ferredoxin-NADP+ reductase activity
I0K03_RS25060	COG0457	Tetratricopeptide repeat
I0K03_RS25065	COG0110	maltose O-acetyltransferase activity
I0K03_RS25085	COG1950	PFAM Membrane protein of
I0K03_RS25095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0K03_RS25100	COG0556	nucleotide-excision repair
I0K03_RS25110	COG0789	Transcriptional regulator
I0K03_RS25130	COG0583	DNA-binding transcription factor activity
I0K03_RS25140	COG0655	NAD(P)H dehydrogenase (quinone) activity
I0K03_RS25155	COG1132	(ABC) transporter
I0K03_RS25160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K03_RS25165	COG0793	Belongs to the peptidase S41A family
I0K03_RS25165	COG3409	Peptidoglycan-binding domain 1 protein
I0K03_RS25170	COG2177	Part of the ABC transporter FtsEX involved in
I0K03_RS25175	COG2884	Cell division ATP-binding protein ftsE
I0K03_RS25195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0K03_RS25200	COG1278	Cold shock
I0K03_RS25205	COG1040	competence protein
I0K03_RS25210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I0K03_RS25215	COG0791	NLP P60 protein
I0K03_RS25215	COG1388	LysM domain
I0K03_RS25220	COG1733	regulation of RNA biosynthetic process
I0K03_RS25225	COG1307	EDD domain protein, DegV family
I0K03_RS25230	COG1739	Uncharacterized protein family UPF0029
I0K03_RS25235	COG1316	TRANSCRIPTIONal
I0K03_RS25240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I0K03_RS25245	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0K03_RS25250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0K03_RS25260	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I0K03_RS25260	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I0K03_RS25280	COG1486	melibiose metabolic process
I0K03_RS25285	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K03_RS25290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K03_RS25300	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I0K03_RS25300	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I0K03_RS25310	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K03_RS25320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K03_RS25325	COG1301	dicarboxylic acid transport
I0K03_RS25335	COG0346	lactoylglutathione lyase activity
I0K03_RS25340	COG1511	domain protein
I0K03_RS25345	COG0583	DNA-binding transcription factor activity
I0K03_RS25350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I0K03_RS25360	COG1271	oxidase subunit
I0K03_RS25365	COG1294	oxidase, subunit
I0K03_RS25375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K03_RS25385	COG1620	l-lactate permease
I0K03_RS25395	COG2389	metal-binding protein
I0K03_RS25405	COG1368	sulfuric ester hydrolase activity
I0K03_RS25415	COG0791	NLP P60 protein
I0K03_RS25415	COG1388	LysM domain
I0K03_RS25420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K03_RS25430	COG1215	transferase activity, transferring glycosyl groups
I0K03_RS25435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K03_RS25440	COG3584	3D domain protein
I0K03_RS25440	COG1388	LysM domain
I0K03_RS25450	COG4715	Zinc finger, swim domain protein
I0K03_RS25455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K03_RS25495	COG0577	efflux transmembrane transporter activity
I0K03_RS25500	COG1136	(ABC) transporter
I0K03_RS25525	COG5002	protein histidine kinase activity
I0K03_RS25525	COG3850	Histidine kinase
I0K03_RS25530	COG0745	RESPONSE REGULATOR receiver
I0K03_RS25535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K03_RS25540	COG4750	Nucleotidyl transferase
I0K03_RS25545	COG0697	spore germination
I0K03_RS25555	COG3475	LICD family
I0K03_RS25570	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0K03_RS25585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I0K03_RS25600	COG0110	maltose O-acetyltransferase activity
I0K03_RS25615	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS25630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I0K03_RS25635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K03_RS25640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K03_RS25645	COG4464	protein tyrosine phosphatase activity
I0K03_RS25650	COG0489	protein tyrosine kinase activity
I0K03_RS25655	COG3944	biosynthesis protein
I0K03_RS25660	COG0489	protein tyrosine kinase activity
I0K03_RS25675	COG1609	Transcriptional regulator
I0K03_RS25685	COG0739	heme binding
I0K03_RS25700	COG3279	Response regulator of the LytR AlgR family
I0K03_RS25705	COG2385	sporulation resulting in formation of a cellular spore
I0K03_RS25720	COG4836	Membrane
I0K03_RS25725	COG1007	ATP synthesis coupled electron transport
I0K03_RS25730	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K03_RS25735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K03_RS25745	COG0839	Belongs to the complex I subunit 6 family
I0K03_RS25765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K03_RS25810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I0K03_RS25830	COG0356	it plays a direct role in the translocation of protons across the membrane
I0K03_RS25865	COG0698	ribose 5-phosphate isomerase
I0K03_RS25875	COG2190	(PTS) system
I0K03_RS25880	COG2259	Doxx family
I0K03_RS25885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K03_RS25900	COG0009	L-threonylcarbamoyladenylate synthase
I0K03_RS25920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I0K03_RS25935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I0K03_RS25940	COG1494	fructose-1,6-bisphosphatase
I0K03_RS25960	COG4821	SIS domain
I0K03_RS25965	COG0504	CTP synthase activity
I0K03_RS25980	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS25985	COG1960	acyl-CoA dehydrogenase activity
I0K03_RS25990	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K03_RS26000	COG2181	nitrate reductase activity
I0K03_RS26000	COG0247	lactate metabolic process
I0K03_RS26005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K03_RS26015	COG3300	MHYT domain
I0K03_RS26015	COG5001	Diguanylate cyclase
I0K03_RS26030	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS26035	COG2197	response regulator
I0K03_RS26040	COG4585	Histidine kinase
I0K03_RS26045	COG0842	Transport permease protein
I0K03_RS26050	COG1131	(ABC) transporter
I0K03_RS26055	COG0024	Methionine aminopeptidase
I0K03_RS26065	COG2234	aminopeptidase activity
I0K03_RS26085	COG4506	Protein conserved in bacteria
I0K03_RS26090	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K03_RS26110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I0K03_RS26115	COG2814	Major facilitator Superfamily
I0K03_RS26120	COG0789	Transcriptional regulator
I0K03_RS26125	COG0584	glycerophosphoryl diester phosphodiesterase
I0K03_RS26130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS26140	COG1994	Peptidase M50
I0K03_RS26150	COG1078	dGTPase activity
I0K03_RS26155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K03_RS26160	COG1120	ATPase activity
I0K03_RS26165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS26170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K03_RS26175	COG4844	belongs to the
I0K03_RS26190	COG0280	phosphate acetyltransferase
I0K03_RS26205	COG3773	Cell wall hydrolase
I0K03_RS26215	COG2363	Small membrane protein
I0K03_RS26225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K03_RS26230	COG2233	PERMEase
I0K03_RS26235	COG0561	phosphatase activity
I0K03_RS26240	COG2814	Major facilitator Superfamily
I0K03_RS26250	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K03_RS26255	COG1131	(ABC) transporter
I0K03_RS26260	COG2755	lipolytic protein G-D-S-L family
I0K03_RS26265	COG1609	Transcriptional regulator
I0K03_RS26275	COG0460	homoserine dehydrogenase
I0K03_RS26285	COG2873	o-acetylhomoserine
I0K03_RS26295	COG1011	Hydrolase
I0K03_RS26300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K03_RS26310	COG2197	response regulator
I0K03_RS26315	COG4585	Histidine kinase
I0K03_RS26315	COG2203	Gaf domain
I0K03_RS26320	COG0351	phosphomethylpyrimidine kinase
I0K03_RS26325	COG3706	GGDEF domain
I0K03_RS26330	COG2879	small protein
I0K03_RS26335	COG1966	Carbon starvation protein
I0K03_RS26340	COG3279	Response regulator of the LytR AlgR family
I0K03_RS26345	COG0477	Major facilitator Superfamily
I0K03_RS26355	COG0438	transferase activity, transferring glycosyl groups
I0K03_RS26370	COG0840	transmembrane signaling receptor activity
I0K03_RS26380	COG1607	acyl-coa hydrolase
I0K03_RS26390	COG1215	transferase activity, transferring glycosyl groups
I0K03_RS26400	COG1309	transcriptional regulator
I0K03_RS26405	COG0488	(ABC) transporter
I0K03_RS26420	COG0463	Glycosyl transferase, family 2
I0K03_RS26425	COG1309	transcriptional regulator
I0K03_RS26430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K03_RS26435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K03_RS26435	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K03_RS26440	COG0628	permease
I0K03_RS26460	COG3275	phosphorelay sensor kinase activity
I0K03_RS26465	COG2814	Major facilitator Superfamily
I0K03_RS26470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K03_RS26475	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I0K03_RS26480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K03_RS26500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K03_RS26505	COG1272	protein, Hemolysin III
I0K03_RS26530	COG1164	Oligoendopeptidase f
I0K03_RS26550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K03_RS26555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I0K03_RS26560	COG4853	Protein conserved in bacteria
I0K03_RS26570	COG5002	protein histidine kinase activity
I0K03_RS26575	COG0745	RESPONSE REGULATOR receiver
I0K03_RS26605	COG0305	Participates in initiation and elongation during chromosome replication
I0K03_RS26615	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I0K03_RS26620	COG4241	membrane
I0K03_RS26630	COG0629	single-stranded DNA binding
I0K03_RS26640	COG0012	GTP binding
I0K03_RS26645	COG4481	Protein conserved in bacteria
I0K03_RS26650	COG0668	transmembrane transport
I0K03_RS26660	COG1475	DNA binding
I0K03_RS26665	COG1192	Involved in chromosome partitioning
I0K03_RS26690	COG1847	R3H domain protein
I0K03_RS26695	COG0706	membrane insertase activity
I0K03_RS26705	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I0K03_RS26720	COG1073	alpha beta
I0K03_RS26740	COG2205	protein histidine kinase activity
I0K03_RS26750	COG1136	(ABC) transporter
I0K03_RS26755	COG0577	efflux transmembrane transporter activity
I0K03_RS26760	COG0789	Transcriptional regulator
I0K03_RS26770	COG5002	protein histidine kinase activity
I0K03_RS26830	COG1396	sequence-specific DNA binding
I0K03_RS26835	COG1378	Sugar-specific transcriptional regulator TrmB
I0K03_RS26845	COG0745	RESPONSE REGULATOR receiver
I0K03_RS26850	COG2205	protein histidine kinase activity
I0K03_RS26855	COG1136	(ABC) transporter
I0K03_RS26860	COG0577	efflux transmembrane transporter activity
I0K03_RS26870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K03_RS26870	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K03_RS26885	COG1136	(ABC) transporter
I0K03_RS26945	COG1136	(ABC) transporter
I0K03_RS26950	COG0577	efflux transmembrane transporter activity
I0K03_RS27015	COG2124	cytochrome p450
I0K03_RS27020	COG1846	Transcriptional regulator
I0K03_RS27025	COG1846	Transcriptional regulator
I0K03_RS27030	COG2814	Major facilitator Superfamily
I0K03_RS27055	COG2184	nucleotidyltransferase activity
I0K03_RS27100	COG1136	(ABC) transporter
I0K03_RS27100	COG0577	efflux transmembrane transporter activity
I0K03_RS27110	COG0745	RESPONSE REGULATOR receiver
I0K03_RS27115	COG3850	Histidine kinase
I0K03_RS27115	COG5002	protein histidine kinase activity
I0K03_RS27145	COG5002	protein histidine kinase activity
I0K03_RS27155	COG2072	flavoprotein involved in K transport
I0K03_RS27160	COG0697	spore germination
I0K03_RS27165	COG1522	sequence-specific DNA binding
I0K03_RS27190	COG2732	(Barnase) inhibitor
I0K03_RS27220	COG5444	nuclease activity
I0K03_RS27225	COG3620	sequence-specific DNA binding
I0K03_RS27240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I0K03_RS27275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0K03_RS27305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K03_RS27315	COG2814	Major facilitator Superfamily
I0K03_RS27320	COG0583	DNA-binding transcription factor activity
I0K03_RS27335	COG0156	8-amino-7-oxononanoate synthase activity
I0K03_RS27340	COG1760	l-serine dehydratase
I0K03_RS27345	COG4974	Belongs to the 'phage' integrase family
I0K03_RS27360	COG1846	Transcriptional regulator
I0K03_RS27375	COG5002	protein histidine kinase activity
I0K03_RS27380	COG0745	RESPONSE REGULATOR receiver
I0K03_RS27385	COG4990	cell redox homeostasis
I0K03_RS27395	COG2259	Doxx family
I0K03_RS27405	COG2040	homocysteine
I0K03_RS27410	COG0833	amino acid
I0K03_RS27415	COG0318	PFAM AMP-dependent synthetase and ligase
I0K03_RS27460	COG1252	NADH dehydrogenase
I0K03_RS27475	COG4641	Protein conserved in bacteria
I0K03_RS27495	COG2089	acid synthase
I0K03_RS27510	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I0K03_RS27515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0K03_RS27520	COG1088	dTDP-glucose 4,6-dehydratase activity
I0K03_RS27525	COG1086	Polysaccharide biosynthesis protein
I0K03_RS27530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I0K03_RS27535	COG0463	Glycosyl transferase, family 2
I0K03_RS27540	COG0463	Glycosyl transferase, family 2
I0K03_RS27545	COG0457	Tetratricopeptide repeat
I0K03_RS27590	COG3104	oligopeptide transport
I0K03_RS27620	COG0457	Tetratricopeptide repeat
I0K03_RS27635	COG0772	Belongs to the SEDS family
I0K03_RS27640	COG3718	enzyme involved in inositol metabolism
I0K03_RS27670	COG0673	inositol 2-dehydrogenase activity
I0K03_RS27675	COG2814	Major facilitator Superfamily
I0K03_RS27680	COG1609	Transcriptional regulator
I0K03_RS27695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0K03_RS27805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K03_RS27805	COG0784	Response regulator, receiver
I0K03_RS27815	COG4585	Histidine kinase
I0K03_RS27880	COG0457	Tetratricopeptide repeat
I0K03_RS27905	COG1484	DNA-dependent DNA replication
I0K03_RS27930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K03_RS27930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K03_RS28165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K03_RS28190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0K03_RS28230	COG0457	Tetratricopeptide repeat
I0K03_RS28240	COG0657	acetylesterase activity
I0K03_RS28250	COG2814	Major facilitator Superfamily
I0K03_RS28255	COG1309	transcriptional regulator
I0K03_RS28305	COG1404	Belongs to the peptidase S8 family
I0K03_RS28320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K03_RS28325	COG1136	(ABC) transporter
I0K03_RS28330	COG0577	efflux transmembrane transporter activity
I0K03_RS28335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K03_RS28345	COG0745	RESPONSE REGULATOR receiver
I0K03_RS28350	COG5002	protein histidine kinase activity
I0K03_RS28355	COG0741	lytic transglycosylase activity
I0K03_RS28430	COG0756	dUTP diphosphatase activity
I0K03_RS28465	COG0583	DNA-binding transcription factor activity
I0K03_RS28470	COG0346	lactoylglutathione lyase activity
I0K03_RS28520	COG0791	NLP P60 protein
I0K03_RS28520	COG0741	lytic transglycosylase activity
I0K03_RS28565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I0K03_RS28650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0K03_RS28685	COG1309	transcriptional regulator
I0K03_RS28690	COG2814	Major facilitator Superfamily
I0K03_RS28835	COG5002	protein histidine kinase activity
I0K03_RS28840	COG0745	RESPONSE REGULATOR receiver
I0K03_RS28845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I0K03_RS28850	COG0463	Glycosyl transferase, family 2
I0K03_RS28870	COG1136	(ABC) transporter
I0K03_RS28875	COG0577	efflux transmembrane transporter activity
I0K03_RS28940	COG2890	protein-(glutamine-N5) methyltransferase activity
I0K03_RS28965	COG3227	Zinc metalloprotease (Elastase)
I0K03_RS28980	COG1999	signal sequence binding
I0K03_RS28985	COG0662	Cupin 2, conserved barrel domain protein
I0K03_RS28995	COG0010	Belongs to the arginase family
I0K03_RS29005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K03_RS29020	COG0456	acetyltransferase
I0K03_RS29060	COG0584	glycerophosphoryl diester phosphodiesterase
I0K03_RS29080	COG0697	spore germination
I0K03_RS29085	COG0583	DNA-binding transcription factor activity