locus-tag	class	description
K6T24_RS00010	COG0592	DNA-directed DNA polymerase activity
K6T24_RS00015	COG2501	S4 domain
K6T24_RS00025	COG0187	DNA topoisomerase II activity
K6T24_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6T24_RS00065	COG0516	GMP reductase activity
K6T24_RS00065	COG0517	IMP dehydrogenase activity
K6T24_RS00070	COG1686	Belongs to the peptidase S11 family
K6T24_RS00100	COG1428	Deoxynucleoside kinase
K6T24_RS00105	COG1428	Deoxynucleoside kinase
K6T24_RS00110	COG1335	isochorismatase
K6T24_RS00115	COG0590	tRNA wobble adenosine to inosine editing
K6T24_RS00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6T24_RS00180	COG1982	Orn Lys Arg decarboxylase major
K6T24_RS00190	COG0470	DNA polymerase III
K6T24_RS00195	COG1774	PSP1 C-terminal conserved region
K6T24_RS00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K6T24_RS00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K6T24_RS00220	COG2002	toxin-antitoxin pair type II binding
K6T24_RS00230	COG0084	hydrolase, TatD family'
K6T24_RS00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6T24_RS00250	COG4466	Protein conserved in bacteria
K6T24_RS00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K6T24_RS00270	COG0251	oxidation-reduction process
K6T24_RS00275	COG2088	sporulation resulting in formation of a cellular spore
K6T24_RS00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K6T24_RS00305	COG2002	toxin-antitoxin pair type II binding
K6T24_RS00310	COG2244	polysaccharide biosynthetic process
K6T24_RS00315	COG3956	TIGRFAM MazG family protein
K6T24_RS00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K6T24_RS00340	COG1098	S1 RNA binding domain
K6T24_RS00355	COG2208	phosphoserine phosphatase activity
K6T24_RS00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6T24_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K6T24_RS00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6T24_RS00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K6T24_RS00395	COG0512	Glutamine amidotransferase of anthranilate synthase
K6T24_RS00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K6T24_RS00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K6T24_RS00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K6T24_RS00420	COG1396	sequence-specific DNA binding
K6T24_RS00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6T24_RS00515	COG3880	PFAM UvrB UvrC protein
K6T24_RS00525	COG0542	response to heat
K6T24_RS00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K6T24_RS00540	COG4956	integral membrane protein (PIN domain superfamily)
K6T24_RS00560	COG1045	serine acetyltransferase
K6T24_RS00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6T24_RS00580	COG3688	RNA-binding protein containing a PIN domain
K6T24_RS00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6T24_RS00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6T24_RS00600	COG0250	Participates in transcription elongation, termination and antitermination
K6T24_RS00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K6T24_RS00610	COG0081	regulation of translation
K6T24_RS00620	COG0222	ribosome binding
K6T24_RS00625	COG2813	Specifically methylates the guanine in position
K6T24_RS00640	COG1358	cellular component organization or biogenesis
K6T24_RS00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K6T24_RS00665	COG0051	transcription antitermination factor activity, RNA binding
K6T24_RS00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K6T24_RS00710	COG0255	Belongs to the universal ribosomal protein uL29 family
K6T24_RS00760	COG1841	ribosomal large subunit assembly
K6T24_RS00770	COG0201	protein transport
K6T24_RS00780	COG0024	Methionine aminopeptidase
K6T24_RS00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K6T24_RS00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K6T24_RS00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS00855	COG0489	protein tyrosine kinase activity
K6T24_RS00865	COG2194	sulfuric ester hydrolase activity
K6T24_RS00870	COG0726	polysaccharide deacetylase
K6T24_RS00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K6T24_RS00955	COG4856	YbbR-like protein
K6T24_RS00990	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS00995	COG2011	ABC-type metal ion transport system permease component
K6T24_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K6T24_RS01005	COG1464	Belongs to the NlpA lipoprotein family
K6T24_RS01010	COG0604	alcohol dehydrogenase
K6T24_RS01020	COG0277	FAD linked oxidase domain protein
K6T24_RS01025	COG2271	Major facilitator Superfamily
K6T24_RS01035	COG2814	Major facilitator Superfamily
K6T24_RS01055	COG2207	Transcriptional regulator
K6T24_RS01065	COG4166	transmembrane transport
K6T24_RS01070	COG4166	transmembrane transport
K6T24_RS01075	COG0656	L-ascorbic acid biosynthetic process
K6T24_RS01095	COG4149	molybdate abc transporter
K6T24_RS01100	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6T24_RS01105	COG1910	domain protein
K6T24_RS01120	COG0697	spore germination
K6T24_RS01135	COG0204	Acyl-transferase
K6T24_RS01145	COG1609	Transcriptional regulator
K6T24_RS01155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS01170	COG5298	Protein conserved in bacteria
K6T24_RS01195	COG0488	(ABC) transporter
K6T24_RS01205	COG0747	negative chemotaxis
K6T24_RS01210	COG0601	transmembrane transport
K6T24_RS01215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6T24_RS01220	COG0444	Belongs to the ABC transporter superfamily
K6T24_RS01225	COG4608	Belongs to the ABC transporter superfamily
K6T24_RS01230	COG0561	phosphatase activity
K6T24_RS01260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K6T24_RS01265	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6T24_RS01275	COG0531	amino acid
K6T24_RS01280	COG2814	Major facilitator Superfamily
K6T24_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K6T24_RS01300	COG4294	response to UV
K6T24_RS01305	COG0705	Rhomboid family
K6T24_RS01315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K6T24_RS01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6T24_RS01325	COG0864	Transcriptional regulator
K6T24_RS01330	COG2337	Toxic component of a toxin-antitoxin (TA) module
K6T24_RS01335	COG2183	response to ionizing radiation
K6T24_RS01435	COG0802	atpase or kinase
K6T24_RS01440	COG1214	PFAM Peptidase M22, glycoprotease
K6T24_RS01445	COG0456	acetyltransferase
K6T24_RS01455	COG0488	(ABC) transporter
K6T24_RS01470	COG1266	CAAX protease self-immunity
K6T24_RS01480	COG0459	protein refolding
K6T24_RS01495	COG2252	PERMEase
K6T24_RS01505	COG5002	protein histidine kinase activity
K6T24_RS01530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6T24_RS01570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6T24_RS01580	COG1215	transferase activity, transferring glycosyl groups
K6T24_RS01600	COG0697	spore germination
K6T24_RS01645	COG2205	protein histidine kinase activity
K6T24_RS01650	COG0745	RESPONSE REGULATOR receiver
K6T24_RS01675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K6T24_RS01680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K6T24_RS01685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K6T24_RS01695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K6T24_RS01700	COG0047	phosphoribosylformylglycinamidine synthase activity
K6T24_RS01710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K6T24_RS01720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K6T24_RS01725	COG0138	bifunctional purine biosynthesis protein purh
K6T24_RS01730	COG0151	Belongs to the GarS family
K6T24_RS01755	COG0210	DNA helicase
K6T24_RS01765	COG4851	CamS sex pheromone cAM373 precursor
K6T24_RS01780	COG1335	isochorismatase
K6T24_RS01790	COG2011	ABC-type metal ion transport system permease component
K6T24_RS01795	COG1464	Belongs to the NlpA lipoprotein family
K6T24_RS01810	COG0003	Pfam Anion-transporting ATPase
K6T24_RS01815	COG1846	Transcriptional regulator
K6T24_RS01820	COG4682	membrane
K6T24_RS01840	COG1597	lipid kinase activity
K6T24_RS01845	COG0546	phosphoglycolate phosphatase activity
K6T24_RS01850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS01860	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS01865	COG2076	Multidrug Resistance protein
K6T24_RS01875	COG2309	aminopeptidase activity
K6T24_RS01890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS01900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K6T24_RS01905	COG5002	protein histidine kinase activity
K6T24_RS01915	COG4807	Protein conserved in bacteria
K6T24_RS01940	COG1757	Na H antiporter
K6T24_RS01945	COG1473	amidohydrolase
K6T24_RS01960	COG0450	alkyl hydroperoxide reductase
K6T24_RS01980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS01990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6T24_RS01995	COG0492	ferredoxin-NADP+ reductase activity
K6T24_RS02005	COG0166	Belongs to the GPI family
K6T24_RS02030	COG5002	protein histidine kinase activity
K6T24_RS02050	COG3541	Predicted nucleotidyltransferase
K6T24_RS02055	COG2814	Major facilitator Superfamily
K6T24_RS02060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6T24_RS02060	COG0723	plastoquinol--plastocyanin reductase activity
K6T24_RS02070	COG0765	amino acid transport
K6T24_RS02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6T24_RS02085	COG0840	transmembrane signaling receptor activity
K6T24_RS02110	COG0549	Belongs to the carbamate kinase family
K6T24_RS02125	COG0277	FAD linked oxidase domain protein
K6T24_RS02130	COG0366	Alpha amylase catalytic
K6T24_RS02135	COG2190	(PTS) system
K6T24_RS02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS02135	COG1263	PTS System
K6T24_RS02200	COG1074	ATP-dependent DNA helicase activity
K6T24_RS02205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K6T24_RS02225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6T24_RS02230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K6T24_RS02250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6T24_RS02260	COG1116	anion transmembrane transporter activity
K6T24_RS02310	COG2270	Major facilitator Superfamily
K6T24_RS02335	COG4193	domain, Protein
K6T24_RS02345	COG2310	stress, protein
K6T24_RS02350	COG2310	stress, protein
K6T24_RS02355	COG2310	stress, protein
K6T24_RS02360	COG0861	Integral membrane protein TerC family
K6T24_RS02370	COG3853	Toxic anion resistance protein (TelA)
K6T24_RS02385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K6T24_RS02395	COG1295	ribonuclease BN
K6T24_RS02400	COG2217	Heavy metal translocating P-type atpase
K6T24_RS02405	COG0697	spore germination
K6T24_RS02425	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS02440	COG3871	stress protein (general stress protein 26)
K6T24_RS02445	COG0387	Pfam Sodium calcium exchanger
K6T24_RS02455	COG0535	radical SAM domain protein
K6T24_RS02475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6T24_RS02495	COG3829	transcription factor binding
K6T24_RS02505	COG0833	amino acid
K6T24_RS02510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6T24_RS02535	COG1263	PTS System
K6T24_RS02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS02540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6T24_RS02560	COG0463	Glycosyl transferase, family 2
K6T24_RS02570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6T24_RS02570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6T24_RS02575	COG0463	Glycosyl transferase, family 2
K6T24_RS02585	COG1882	Formate acetyltransferase
K6T24_RS02590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K6T24_RS02610	COG1228	amidohydrolase
K6T24_RS02615	COG1090	epimerase
K6T24_RS02645	COG1988	membrane-bound metal-dependent
K6T24_RS02650	COG1194	a g-specific adenine glycosylase
K6T24_RS02670	COG3557	Belongs to the UPF0374 family
K6T24_RS02675	COG1132	(ABC) transporter
K6T24_RS02680	COG4129	membrane
K6T24_RS02685	COG0067	glutamate synthase
K6T24_RS02685	COG0070	glutamate synthase
K6T24_RS02685	COG0069	glutamate synthase activity
K6T24_RS02690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K6T24_RS02695	COG4555	ABC transporter
K6T24_RS02715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K6T24_RS02720	COG0735	belongs to the Fur family
K6T24_RS02840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K6T24_RS02865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K6T24_RS02870	COG1716	ATPase activity
K6T24_RS02870	COG5001	Diguanylate cyclase
K6T24_RS02875	COG2766	serine protein kinase
K6T24_RS02880	COG2718	Belongs to the UPF0229 family
K6T24_RS02895	COG1585	Membrane protein implicated in regulation of membrane protease activity
K6T24_RS02900	COG2268	Band 7 protein
K6T24_RS02910	COG3290	protein histidine kinase activity
K6T24_RS02915	COG4565	transcriptional regulatory protein
K6T24_RS02920	COG2851	Citrate transporter
K6T24_RS02945	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K6T24_RS02950	COG3842	ATPase activity
K6T24_RS02955	COG1175	transmembrane transport
K6T24_RS02960	COG0395	ABC-type sugar transport system, permease component
K6T24_RS02970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K6T24_RS02975	COG0745	RESPONSE REGULATOR receiver
K6T24_RS02980	COG5002	protein histidine kinase activity
K6T24_RS02990	COG4990	cell redox homeostasis
K6T24_RS03000	COG3290	protein histidine kinase activity
K6T24_RS03005	COG4565	transcriptional regulatory protein
K6T24_RS03010	COG3493	citrate carrier protein
K6T24_RS03015	COG0281	malic enzyme
K6T24_RS03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS03040	COG5002	protein histidine kinase activity
K6T24_RS03045	COG0745	RESPONSE REGULATOR receiver
K6T24_RS03050	COG0454	-acetyltransferase
K6T24_RS03050	COG0456	acetyltransferase
K6T24_RS03055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6T24_RS03060	COG3383	formate dehydrogenase (NAD+) activity
K6T24_RS03065	COG2427	Protein of unknown function (DUF1641)
K6T24_RS03080	COG0531	amino acid
K6T24_RS03090	COG0640	Transcriptional regulator
K6T24_RS03095	COG2217	Heavy metal translocating P-type atpase
K6T24_RS03100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K6T24_RS03115	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS03135	COG2720	vancomycin resistance protein
K6T24_RS03140	COG1316	TRANSCRIPTIONal
K6T24_RS03145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS03150	COG0346	lactoylglutathione lyase activity
K6T24_RS03155	COG1253	flavin adenine dinucleotide binding
K6T24_RS03160	COG1027	Aspartate ammonia-lyase
K6T24_RS03165	COG1620	l-lactate permease
K6T24_RS03180	COG3104	oligopeptide transport
K6T24_RS03185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6T24_RS03190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS03195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS03205	COG2226	methyltransferase
K6T24_RS03215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K6T24_RS03225	COG4548	von Willebrand factor, type A
K6T24_RS03230	COG0714	Associated with various cellular activities
K6T24_RS03250	COG0531	amino acid
K6T24_RS03255	COG2188	Transcriptional regulator
K6T24_RS03260	COG1263	PTS System
K6T24_RS03260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS03265	COG0366	Alpha amylase catalytic
K6T24_RS03280	COG0697	spore germination
K6T24_RS03285	COG4585	Histidine kinase
K6T24_RS03290	COG2197	response regulator
K6T24_RS03295	COG1404	Belongs to the peptidase S8 family
K6T24_RS03305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6T24_RS03310	COG1115	amino acid carrier protein
K6T24_RS03315	COG1126	abc transporter atp-binding protein
K6T24_RS03320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6T24_RS03325	COG0765	amino acid transport
K6T24_RS03330	COG0765	amino acid transport
K6T24_RS03335	COG0833	amino acid
K6T24_RS03360	COG2378	regulation of single-species biofilm formation
K6T24_RS03365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K6T24_RS03370	COG5002	protein histidine kinase activity
K6T24_RS03375	COG0745	RESPONSE REGULATOR receiver
K6T24_RS03385	COG0659	secondary active sulfate transmembrane transporter activity
K6T24_RS03400	COG2271	Major facilitator Superfamily
K6T24_RS03405	COG1846	Transcriptional regulator
K6T24_RS03410	COG0477	Major facilitator Superfamily
K6T24_RS03415	COG1609	Transcriptional regulator
K6T24_RS03420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K6T24_RS03435	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS03440	COG1879	ABC-type sugar transport system periplasmic component
K6T24_RS03470	COG1063	alcohol dehydrogenase
K6T24_RS03520	COG0840	transmembrane signaling receptor activity
K6T24_RS03525	COG1388	LysM domain
K6T24_RS03525	COG3584	3D domain protein
K6T24_RS03530	COG1476	TRANSCRIPTIONal
K6T24_RS03550	COG3104	oligopeptide transport
K6T24_RS03555	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS03570	COG1113	amino acid transport
K6T24_RS03575	COG2252	PERMEase
K6T24_RS03600	COG0475	glutathione-regulated potassium exporter activity
K6T24_RS03600	COG0569	domain protein
K6T24_RS03615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K6T24_RS03620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K6T24_RS03625	COG0833	amino acid
K6T24_RS03630	COG4990	cell redox homeostasis
K6T24_RS03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6T24_RS03650	COG0697	spore germination
K6T24_RS03655	COG0531	amino acid
K6T24_RS03665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6T24_RS03670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6T24_RS03675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K6T24_RS03675	COG1918	ferrous iron import across plasma membrane
K6T24_RS03680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6T24_RS03685	COG0573	inorganic phosphate transmembrane transporter activity
K6T24_RS03690	COG0581	inorganic phosphate transmembrane transporter activity
K6T24_RS03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6T24_RS03820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K6T24_RS03840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6T24_RS03845	COG1116	anion transmembrane transporter activity
K6T24_RS03850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6T24_RS03855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6T24_RS03860	COG0352	thiamine-phosphate diphosphorylase activity
K6T24_RS03865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6T24_RS03870	COG2104	thiamine diphosphate biosynthetic process
K6T24_RS03875	COG2022	thiamine diphosphate biosynthetic process
K6T24_RS03880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6T24_RS03885	COG0351	phosphomethylpyrimidine kinase
K6T24_RS03910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K6T24_RS03915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K6T24_RS03920	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K6T24_RS03925	COG2205	protein histidine kinase activity
K6T24_RS03930	COG2814	Major facilitator Superfamily
K6T24_RS03935	COG1846	Transcriptional regulator
K6T24_RS03955	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS03960	COG1129	ABC transporter
K6T24_RS03970	COG2252	PERMEase
K6T24_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS04035	COG0778	Nitroreductase
K6T24_RS04040	COG2719	SpoVR family
K6T24_RS04065	COG0446	pyridine nucleotide-disulphide oxidoreductase
K6T24_RS04070	COG1937	Protein conserved in bacteria
K6T24_RS04075	COG0425	Belongs to the sulfur carrier protein TusA family
K6T24_RS04075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS04080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS04080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS04085	COG0425	Belongs to the sulfur carrier protein TusA family
K6T24_RS04090	COG0425	Belongs to the sulfur carrier protein TusA family
K6T24_RS04090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS04095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS04100	COG2210	Belongs to the sulfur carrier protein TusA family
K6T24_RS04105	COG0730	response to heat
K6T24_RS04115	COG1316	TRANSCRIPTIONal
K6T24_RS04120	COG0604	alcohol dehydrogenase
K6T24_RS04125	COG1283	sodium-dependent phosphate transmembrane transporter activity
K6T24_RS04130	COG2814	Major facilitator Superfamily
K6T24_RS04140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6T24_RS04140	COG3711	transcriptional antiterminator
K6T24_RS04145	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6T24_RS04150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6T24_RS04170	COG1388	LysM domain
K6T24_RS04170	COG3584	3D domain protein
K6T24_RS04175	COG0577	efflux transmembrane transporter activity
K6T24_RS04180	COG1136	(ABC) transporter
K6T24_RS04205	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS04210	COG3546	catalase activity
K6T24_RS04245	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS04280	COG0531	amino acid
K6T24_RS04285	COG0475	glutathione-regulated potassium exporter activity
K6T24_RS04295	COG1737	Transcriptional regulator
K6T24_RS04305	COG1263	PTS System
K6T24_RS04305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS04315	COG2259	Doxx family
K6T24_RS04330	COG0697	spore germination
K6T24_RS04335	COG1522	sequence-specific DNA binding
K6T24_RS04365	COG2076	Multidrug Resistance protein
K6T24_RS04370	COG1309	transcriptional regulator
K6T24_RS04375	COG2814	Major facilitator Superfamily
K6T24_RS04380	COG1733	regulation of RNA biosynthetic process
K6T24_RS04390	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6T24_RS04400	COG4533	DNA binding
K6T24_RS04405	COG2211	Major facilitator Superfamily
K6T24_RS04415	COG0693	protein deglycase activity
K6T24_RS04425	COG0531	amino acid
K6T24_RS04430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K6T24_RS04435	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS04440	COG1132	(ABC) transporter
K6T24_RS04445	COG1132	(ABC) transporter
K6T24_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6T24_RS04455	COG0765	amino acid transport
K6T24_RS04460	COG1126	abc transporter atp-binding protein
K6T24_RS04475	COG0189	ligase activity
K6T24_RS04495	COG0028	Belongs to the TPP enzyme family
K6T24_RS04500	COG3527	Alpha-acetolactate decarboxylase
K6T24_RS04510	COG0561	phosphatase activity
K6T24_RS04520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6T24_RS04530	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS04540	COG0789	Transcriptional regulator
K6T24_RS04540	COG4978	Transcriptional regulator
K6T24_RS04550	COG0659	secondary active sulfate transmembrane transporter activity
K6T24_RS04560	COG1024	Enoyl-CoA hydratase
K6T24_RS04580	COG1363	Peptidase, m42
K6T24_RS04610	COG0579	oxidoreductase
K6T24_RS04635	COG0601	transmembrane transport
K6T24_RS04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6T24_RS04645	COG0444	Belongs to the ABC transporter superfamily
K6T24_RS04650	COG4608	Belongs to the ABC transporter superfamily
K6T24_RS04720	COG0477	Major facilitator Superfamily
K6T24_RS04725	COG3290	protein histidine kinase activity
K6T24_RS04730	COG4565	transcriptional regulatory protein
K6T24_RS04735	COG3181	Tripartite tricarboxylate transporter family receptor
K6T24_RS04775	COG0305	Participates in initiation and elongation during chromosome replication
K6T24_RS04780	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS04800	COG0477	Major facilitator Superfamily
K6T24_RS04840	COG3409	Peptidoglycan-binding domain 1 protein
K6T24_RS04840	COG5632	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS04850	COG3711	transcriptional antiterminator
K6T24_RS04855	COG1263	PTS System
K6T24_RS04855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS04855	COG2190	(PTS) system
K6T24_RS04860	COG2723	6-phospho-beta-galactosidase activity
K6T24_RS04870	COG1183	phosphatidylcholine synthase activity
K6T24_RS04900	COG2814	Major facilitator Superfamily
K6T24_RS04905	COG0640	Transcriptional regulator
K6T24_RS04920	COG2376	Dihydroxyacetone kinase
K6T24_RS04930	COG2376	Dihydroxyacetone kinase
K6T24_RS04940	COG1959	2 iron, 2 sulfur cluster binding
K6T24_RS04955	COG0745	RESPONSE REGULATOR receiver
K6T24_RS04960	COG5002	protein histidine kinase activity
K6T24_RS04960	COG3850	Histidine kinase
K6T24_RS05000	COG3237	CsbD-like
K6T24_RS05025	COG1191	sigma factor activity
K6T24_RS05035	COG2208	phosphoserine phosphatase activity
K6T24_RS05040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6T24_RS05045	COG2198	Histidine kinase
K6T24_RS05045	COG2205	protein histidine kinase activity
K6T24_RS05045	COG0784	Response regulator, receiver
K6T24_RS05100	COG0420	3'-5' exonuclease activity
K6T24_RS05105	COG4717	serine-type aminopeptidase activity
K6T24_RS05125	COG0346	lactoylglutathione lyase activity
K6T24_RS05130	COG0346	lactoylglutathione lyase activity
K6T24_RS05135	COG0457	Tetratricopeptide repeat
K6T24_RS05145	COG2267	carboxylic ester hydrolase activity
K6T24_RS05155	COG3620	sequence-specific DNA binding
K6T24_RS05160	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K6T24_RS05165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K6T24_RS05170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K6T24_RS05175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K6T24_RS05195	COG3973	AAA domain
K6T24_RS05200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6T24_RS05225	COG0537	adenosine 5'-monophosphoramidase activity
K6T24_RS05230	COG1131	(ABC) transporter
K6T24_RS05235	COG4473	ABC transporter
K6T24_RS05250	COG1309	transcriptional regulator
K6T24_RS05260	COG3402	PFAM membrane-flanked domain
K6T24_RS05265	COG3428	Bacterial PH domain
K6T24_RS05305	COG3402	PFAM membrane-flanked domain
K6T24_RS05310	COG3428	Bacterial PH domain
K6T24_RS05315	COG2329	Antibiotic biosynthesis monooxygenase
K6T24_RS05320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6T24_RS05330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K6T24_RS05335	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K6T24_RS05360	COG1309	transcriptional regulator
K6T24_RS05365	COG1511	domain protein
K6T24_RS05410	COG1609	Transcriptional regulator
K6T24_RS05420	COG1234	tRNA 3'-trailer cleavage
K6T24_RS05425	COG0095	Lipoate-protein ligase
K6T24_RS05435	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS05460	COG1408	metallophosphoesterase
K6T24_RS05470	COG1078	dGTPase activity
K6T24_RS05480	COG1595	DNA-templated transcription, initiation
K6T24_RS05485	COG2207	Transcriptional regulator
K6T24_RS05485	COG3708	Transcriptional regulator
K6T24_RS05500	COG2205	protein histidine kinase activity
K6T24_RS05505	COG0745	RESPONSE REGULATOR receiver
K6T24_RS05530	COG0501	Belongs to the peptidase M48B family
K6T24_RS05535	COG0840	transmembrane signaling receptor activity
K6T24_RS05540	COG0697	spore germination
K6T24_RS05545	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K6T24_RS05550	COG2224	Isocitrate lyase
K6T24_RS05580	COG4903	ComK protein
K6T24_RS05585	COG0398	Pfam SNARE associated Golgi protein
K6T24_RS05645	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6T24_RS05670	COG0367	asparagine synthase
K6T24_RS05680	COG0753	catalase activity
K6T24_RS05685	COG0004	ammonium transporteR
K6T24_RS05705	COG2996	Protein conserved in bacteria
K6T24_RS05725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS05740	COG0561	phosphatase activity
K6T24_RS05760	COG2267	carboxylic ester hydrolase activity
K6T24_RS05775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6T24_RS05780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K6T24_RS05785	COG5504	Zn-dependent protease
K6T24_RS05795	COG0180	Tryptophanyl-tRNA synthetase
K6T24_RS05805	COG4166	transmembrane transport
K6T24_RS05810	COG0601	transmembrane transport
K6T24_RS05815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K6T24_RS05820	COG0444	Belongs to the ABC transporter superfamily
K6T24_RS05825	COG4608	Belongs to the ABC transporter superfamily
K6T24_RS05830	COG0534	Mate efflux family protein
K6T24_RS05835	COG4166	transmembrane transport
K6T24_RS05850	COG0861	Integral membrane protein TerC family
K6T24_RS05860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6T24_RS05870	COG1164	Oligoendopeptidase f
K6T24_RS05880	COG2346	COG2346, Truncated hemoglobins
K6T24_RS05885	COG4116	CYTH
K6T24_RS05895	COG2357	RelA SpoT domain protein
K6T24_RS05905	COG0564	pseudouridine synthase activity
K6T24_RS05920	COG0772	Belongs to the SEDS family
K6T24_RS05925	COG1216	Glycosyl transferase, family 2
K6T24_RS05945	COG0457	Tetratricopeptide repeat
K6T24_RS05945	COG0463	Glycosyl transferase, family 2
K6T24_RS05965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K6T24_RS05980	COG1091	dTDP-4-dehydrorhamnose reductase activity
K6T24_RS06025	COG2153	protein acetylation
K6T24_RS06035	COG2382	esterase
K6T24_RS06050	COG5492	domain, Protein
K6T24_RS06055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6T24_RS06065	COG0512	Glutamine amidotransferase of anthranilate synthase
K6T24_RS06065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6T24_RS06070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K6T24_RS06100	COG1620	l-lactate permease
K6T24_RS06105	COG5634	Uncharacterized conserved protein (DUF2278)
K6T24_RS06185	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6T24_RS06195	COG1476	TRANSCRIPTIONal
K6T24_RS06235	COG4152	abc transporter atp-binding protein
K6T24_RS06240	COG1668	transmembrane transport
K6T24_RS06305	COG0582	viral genome integration into host DNA
K6T24_RS06330	COG1686	Belongs to the peptidase S11 family
K6T24_RS06335	COG0681	Belongs to the peptidase S26 family
K6T24_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS06380	COG1176	ABC-type spermidine putrescine transport system, permease component I
K6T24_RS06385	COG1177	transmembrane transport
K6T24_RS06390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K6T24_RS06400	COG2409	Drug exporters of the RND superfamily
K6T24_RS06410	COG0564	pseudouridine synthase activity
K6T24_RS06420	COG2340	Cysteine-rich secretory protein family
K6T24_RS06425	COG0247	lactate metabolic process
K6T24_RS06430	COG0277	FAD linked oxidase domain protein
K6T24_RS06435	COG3835	regulator
K6T24_RS06445	COG0745	RESPONSE REGULATOR receiver
K6T24_RS06450	COG5002	protein histidine kinase activity
K6T24_RS06455	COG2186	Transcriptional regulator
K6T24_RS06475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K6T24_RS06485	COG2116	formate transmembrane transporter activity
K6T24_RS06490	COG0861	Integral membrane protein TerC family
K6T24_RS06495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6T24_RS06505	COG2030	dehydratase
K6T24_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS06530	COG3243	poly(R)-hydroxyalkanoic acid synthase
K6T24_RS06540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6T24_RS06555	COG1840	ABC-type Fe3 transport system, periplasmic component
K6T24_RS06560	COG3842	ATPase activity
K6T24_RS06585	COG1349	DNA-binding transcription factor activity
K6T24_RS06595	COG0235	Class ii aldolase
K6T24_RS06605	COG2861	carbohydrate metabolic process
K6T24_RS06615	COG3852	Histidine kinase
K6T24_RS06620	COG1846	Transcriptional regulator
K6T24_RS06630	COG2318	DinB family
K6T24_RS06640	COG5002	protein histidine kinase activity
K6T24_RS06650	COG0720	synthase
K6T24_RS06665	COG4873	Protein conserved in bacteria
K6T24_RS06680	COG0456	acetyltransferase
K6T24_RS06695	COG1780	Probably involved in ribonucleotide reductase function
K6T24_RS06710	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K6T24_RS06715	COG0531	amino acid
K6T24_RS06720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6T24_RS06735	COG2204	response regulator
K6T24_RS06740	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS06750	COG1725	Transcriptional regulator
K6T24_RS06755	COG1131	(ABC) transporter
K6T24_RS06765	COG1131	(ABC) transporter
K6T24_RS06770	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6T24_RS06775	COG1266	CAAX protease self-immunity
K6T24_RS06785	COG1522	sequence-specific DNA binding
K6T24_RS06795	COG1335	isochorismatase
K6T24_RS06810	COG2070	2-Nitropropane dioxygenase
K6T24_RS06815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K6T24_RS06825	COG1696	Membrane protein involved in D-alanine export
K6T24_RS06850	COG0716	FMN binding
K6T24_RS06885	COG0534	Mate efflux family protein
K6T24_RS06915	COG1846	Transcriptional regulator
K6T24_RS06925	COG1301	dicarboxylic acid transport
K6T24_RS06930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K6T24_RS06935	COG4709	membrane
K6T24_RS06940	COG3874	Sporulation protein YtfJ
K6T24_RS06960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS06965	COG0028	Belongs to the TPP enzyme family
K6T24_RS06970	COG0440	acetolactate synthase activity
K6T24_RS06990	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K6T24_RS07020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K6T24_RS07030	COG0107	imidazoleglycerol-phosphate synthase activity
K6T24_RS07040	COG0140	phosphoribosyl-ATP diphosphatase activity
K6T24_RS07045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6T24_RS07055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6T24_RS07060	COG1183	phosphatidylcholine synthase activity
K6T24_RS07065	COG1368	sulfuric ester hydrolase activity
K6T24_RS07075	COG0019	diaminopimelate decarboxylase activity
K6T24_RS07095	COG0529	Catalyzes the synthesis of activated sulfate
K6T24_RS07100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6T24_RS07120	COG1648	precorrin-2 dehydrogenase activity
K6T24_RS07125	COG0733	neurotransmitter:sodium symporter activity
K6T24_RS07150	COG1757	Na H antiporter
K6T24_RS07165	COG4758	membrane
K6T24_RS07170	COG4585	Histidine kinase
K6T24_RS07175	COG2197	response regulator
K6T24_RS07185	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS07195	COG2226	methyltransferase
K6T24_RS07235	COG0730	response to heat
K6T24_RS07240	COG0306	phosphate transporter
K6T24_RS07245	COG1392	Phosphate transport regulator
K6T24_RS07250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6T24_RS07265	COG3852	Histidine kinase
K6T24_RS07270	COG1801	Protein of unknown function DUF72
K6T24_RS07280	COG0582	viral genome integration into host DNA
K6T24_RS07285	COG5002	protein histidine kinase activity
K6T24_RS07300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K6T24_RS07300	COG0392	lysyltransferase activity
K6T24_RS07315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6T24_RS07320	COG1686	Belongs to the peptidase S11 family
K6T24_RS07325	COG2715	membrane protein required for spore maturation
K6T24_RS07330	COG0700	Nucleoside recognition
K6T24_RS07335	COG1187	pseudouridine synthase activity
K6T24_RS07345	COG1333	cytochrome c biogenesis protein
K6T24_RS07350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6T24_RS07355	COG0745	RESPONSE REGULATOR receiver
K6T24_RS07360	COG5002	protein histidine kinase activity
K6T24_RS07365	COG2096	Adenosyltransferase
K6T24_RS07370	COG4942	peptidase
K6T24_RS07380	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K6T24_RS07385	COG1141	Ferredoxin
K6T24_RS07390	COG4955	Helix-turn-helix domain
K6T24_RS07395	COG0514	ATP-dependent DNA helicase (RecQ)
K6T24_RS07400	COG1266	CAAX protease self-immunity
K6T24_RS07410	COG1408	metallophosphoesterase
K6T24_RS07415	COG0789	Transcriptional regulator
K6T24_RS07420	COG4862	establishment of competence for transformation
K6T24_RS07425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K6T24_RS07445	COG0492	ferredoxin-NADP+ reductase activity
K6T24_RS07520	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6T24_RS07535	COG0142	geranyltranstransferase activity
K6T24_RS07545	COG0142	geranyltranstransferase activity
K6T24_RS07570	COG0457	Tetratricopeptide repeat
K6T24_RS07590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6T24_RS07595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K6T24_RS07595	COG2010	Cytochrome c
K6T24_RS07600	COG4347	Protein of unknown function (DUF1405)
K6T24_RS07615	COG2738	Putative neutral zinc metallopeptidase
K6T24_RS07625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS07630	COG1694	Mazg nucleotide pyrophosphohydrolase
K6T24_RS07645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6T24_RS07650	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS07685	COG1199	ATP-dependent helicase activity
K6T24_RS07685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K6T24_RS07705	COG3935	DnaD domain protein
K6T24_RS07710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K6T24_RS07720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6T24_RS07720	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6T24_RS07765	COG3599	regulation of cell shape
K6T24_RS07775	COG0116	Belongs to the methyltransferase superfamily
K6T24_RS07785	COG1199	ATP-dependent helicase activity
K6T24_RS07790	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K6T24_RS07800	COG3173	Aminoglycoside phosphotransferase
K6T24_RS07805	COG0024	Methionine aminopeptidase
K6T24_RS07815	COG2233	PERMEase
K6T24_RS07820	COG2311	Membrane
K6T24_RS07825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K6T24_RS07835	COG0456	acetyltransferase
K6T24_RS07870	COG0754	glutathionylspermidine amidase activity
K6T24_RS07885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6T24_RS07900	COG0454	-acetyltransferase
K6T24_RS07920	COG0328	RNA-DNA hybrid ribonuclease activity
K6T24_RS07955	COG3403	YqcI/YcgG family
K6T24_RS07960	COG1280	lysine exporter protein (LysE YggA)
K6T24_RS07975	COG3162	membrane
K6T24_RS07980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K6T24_RS07985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6T24_RS07995	COG0475	glutathione-regulated potassium exporter activity
K6T24_RS08000	COG0789	Transcriptional regulator
K6T24_RS08000	COG4978	Transcriptional regulator
K6T24_RS08010	COG2323	membrane
K6T24_RS08015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K6T24_RS08050	COG2814	Major facilitator Superfamily
K6T24_RS08070	COG1923	regulation of RNA biosynthetic process
K6T24_RS08080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6T24_RS08085	COG1360	Flagellar Motor Protein
K6T24_RS08090	COG2201	protein-glutamate methylesterase activity
K6T24_RS08095	COG2198	Histidine kinase
K6T24_RS08095	COG0643	Histidine kinase
K6T24_RS08100	COG1776	CheC inhibitor of MCP methylation
K6T24_RS08100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6T24_RS08115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K6T24_RS08135	COG1256	bacterial-type flagellum assembly
K6T24_RS08140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6T24_RS08160	COG1815	bacterial-type flagellum-dependent cell motility
K6T24_RS08165	COG1558	bacterial-type flagellum-dependent cell motility
K6T24_RS08175	COG1766	The M ring may be actively involved in energy transduction
K6T24_RS08180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6T24_RS08190	COG1157	protein secretion by the type III secretion system
K6T24_RS08210	COG1749	Flagellar hook protein flgE
K6T24_RS08225	COG0835	chemotaxis
K6T24_RS08225	COG0784	Response regulator, receiver
K6T24_RS08240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K6T24_RS08245	COG0741	lytic transglycosylase activity
K6T24_RS08255	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6T24_RS08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K6T24_RS08260	COG1776	CheC inhibitor of MCP methylation
K6T24_RS08270	COG1338	Plays a role in the flagellum-specific transport system
K6T24_RS08275	COG1987	bacterial-type flagellum assembly
K6T24_RS08285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6T24_RS08290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K6T24_RS08295	COG1419	protein localization to endoplasmic reticulum
K6T24_RS08300	COG4787	bacterial-type flagellum-dependent cell motility
K6T24_RS08305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6T24_RS08340	COG2329	Antibiotic biosynthesis monooxygenase
K6T24_RS08355	COG2814	Major facilitator Superfamily
K6T24_RS08365	COG0583	DNA-binding transcription factor activity
K6T24_RS08370	COG3842	ATPase activity
K6T24_RS08375	COG1840	ABC-type Fe3 transport system, periplasmic component
K6T24_RS08385	COG1234	tRNA 3'-trailer cleavage
K6T24_RS08420	COG0406	alpha-ribazole phosphatase activity
K6T24_RS08440	COG1846	Transcriptional regulator
K6T24_RS08450	COG0367	asparagine synthase
K6T24_RS08480	COG1802	Transcriptional regulator
K6T24_RS08485	COG0697	spore germination
K6T24_RS08495	COG0523	cobalamin synthesis protein
K6T24_RS08500	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS08500	COG1216	Glycosyl transferase, family 2
K6T24_RS08505	COG1757	Na H antiporter
K6T24_RS08510	COG0789	Transcriptional regulator
K6T24_RS08515	COG4221	oxidoreductase activity
K6T24_RS08535	COG0534	Mate efflux family protein
K6T24_RS08540	COG3340	Belongs to the peptidase S51 family
K6T24_RS08560	COG0785	Cytochrome C biogenesis protein
K6T24_RS08565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6T24_RS08585	COG2733	membrane
K6T24_RS08620	COG1131	(ABC) transporter
K6T24_RS08635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6T24_RS08640	COG0528	UMP kinase activity
K6T24_RS08650	COG1027	Aspartate ammonia-lyase
K6T24_RS08655	COG0281	malic enzyme
K6T24_RS08660	COG4191	Histidine kinase
K6T24_RS08665	COG0784	Response regulator, receiver
K6T24_RS08670	COG1846	Transcriptional regulator
K6T24_RS08680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6T24_RS08695	COG3620	sequence-specific DNA binding
K6T24_RS08725	COG2814	Major facilitator Superfamily
K6T24_RS08750	COG0477	Major facilitator Superfamily
K6T24_RS08755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6T24_RS08765	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6T24_RS08770	COG2223	nitrite transmembrane transporter activity
K6T24_RS08775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6T24_RS08790	COG2244	polysaccharide biosynthetic process
K6T24_RS08795	COG0733	neurotransmitter:sodium symporter activity
K6T24_RS08805	COG5566	PFAM Mor transcription activator
K6T24_RS08810	COG2323	membrane
K6T24_RS08830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6T24_RS08840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS08845	COG0028	Belongs to the TPP enzyme family
K6T24_RS08865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K6T24_RS08890	COG2814	Major facilitator Superfamily
K6T24_RS08895	COG3384	dioxygenase
K6T24_RS08905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6T24_RS08925	COG4166	transmembrane transport
K6T24_RS08955	COG0535	radical SAM domain protein
K6T24_RS08960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS08980	COG1914	H( )-stimulated, divalent metal cation uptake system
K6T24_RS08995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6T24_RS09000	COG0531	amino acid
K6T24_RS09025	COG1266	CAAX protease self-immunity
K6T24_RS09030	COG1309	transcriptional regulator
K6T24_RS09035	COG2390	Transcriptional regulator
K6T24_RS09045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS09050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K6T24_RS09055	COG0295	cytidine deaminase activity
K6T24_RS09085	COG0583	DNA-binding transcription factor activity
K6T24_RS09100	COG0006	proline dipeptidase activity
K6T24_RS09105	COG2132	Multicopper oxidase
K6T24_RS09145	COG1760	l-serine dehydratase
K6T24_RS09150	COG1760	l-serine dehydratase
K6T24_RS09155	COG0814	amino acid
K6T24_RS09175	COG1136	(ABC) transporter
K6T24_RS09180	COG0577	efflux transmembrane transporter activity
K6T24_RS09185	COG0745	RESPONSE REGULATOR receiver
K6T24_RS09190	COG2205	protein histidine kinase activity
K6T24_RS09235	COG0772	Belongs to the SEDS family
K6T24_RS09240	COG2239	Acts as a magnesium transporter
K6T24_RS09250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6T24_RS09270	COG1073	alpha beta
K6T24_RS09295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6T24_RS09305	COG0583	DNA-binding transcription factor activity
K6T24_RS09325	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS09335	COG1276	copper resistance
K6T24_RS09335	COG2372	response to copper ion
K6T24_RS09340	COG4549	nuclear export factor GLE1
K6T24_RS09345	COG0697	spore germination
K6T24_RS09350	COG0583	DNA-binding transcription factor activity
K6T24_RS09355	COG1959	2 iron, 2 sulfur cluster binding
K6T24_RS09360	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6T24_RS09365	COG0778	Nitroreductase
K6T24_RS09375	COG0628	permease
K6T24_RS09390	COG1231	oxidoreductase activity
K6T24_RS09395	COG0523	cobalamin synthesis protein
K6T24_RS09405	COG0411	ABC transporter
K6T24_RS09415	COG0559	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS09425	COG0583	DNA-binding transcription factor activity
K6T24_RS09450	COG1271	oxidase subunit
K6T24_RS09455	COG1294	oxidase, subunit
K6T24_RS09460	COG4988	ABC transporter
K6T24_RS09465	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K6T24_RS09470	COG1216	Glycosyl transferase, family 2
K6T24_RS09490	COG1686	Belongs to the peptidase S11 family
K6T24_RS09505	COG1388	LysM domain
K6T24_RS09505	COG0791	NLP P60 protein
K6T24_RS09515	COG1132	(ABC) transporter
K6T24_RS09520	COG0745	RESPONSE REGULATOR receiver
K6T24_RS09525	COG5002	protein histidine kinase activity
K6T24_RS09530	COG0300	oxidoreductase activity
K6T24_RS09555	COG5658	integral membrane protein
K6T24_RS09570	COG0460	homoserine dehydrogenase
K6T24_RS09580	COG0083	homoserine kinase activity
K6T24_RS09595	COG1316	TRANSCRIPTIONal
K6T24_RS09605	COG0745	RESPONSE REGULATOR receiver
K6T24_RS09610	COG5002	protein histidine kinase activity
K6T24_RS09625	COG1285	pathogenesis
K6T24_RS09630	COG1247	-acetyltransferase
K6T24_RS09650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6T24_RS09660	COG1082	Xylose isomerase domain protein TIM barrel
K6T24_RS09670	COG2814	Major facilitator Superfamily
K6T24_RS09675	COG1279	arginine transmembrane transporter activity
K6T24_RS09680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS09690	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6T24_RS09725	COG0577	efflux transmembrane transporter activity
K6T24_RS09730	COG2002	toxin-antitoxin pair type II binding
K6T24_RS09735	COG1404	Belongs to the peptidase S8 family
K6T24_RS09740	COG0640	Transcriptional regulator
K6T24_RS09745	COG0667	Aldo Keto reductase
K6T24_RS09785	COG3949	Membrane
K6T24_RS09790	COG0783	Belongs to the Dps family
K6T24_RS09805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6T24_RS09815	COG1231	oxidoreductase activity
K6T24_RS09820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS09825	COG4989	oxidoreductase activity
K6T24_RS09830	COG0523	cobalamin synthesis protein
K6T24_RS09835	COG0456	acetyltransferase
K6T24_RS09840	COG0803	Belongs to the bacterial solute-binding protein 9 family
K6T24_RS09850	COG0702	epimerase
K6T24_RS09860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6T24_RS09870	COG4166	transmembrane transport
K6T24_RS09875	COG0346	lactoylglutathione lyase activity
K6T24_RS09885	COG0406	alpha-ribazole phosphatase activity
K6T24_RS09895	COG5337	Spore coat protein CotH
K6T24_RS09900	COG1051	belongs to the nudix hydrolase family
K6T24_RS09905	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS09910	COG2244	polysaccharide biosynthetic process
K6T24_RS09920	COG0701	Predicted permease
K6T24_RS09925	COG3689	TIGRFAM TIGR03943 family protein
K6T24_RS09930	COG1607	acyl-coa hydrolase
K6T24_RS09940	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6T24_RS09955	COG0702	epimerase
K6T24_RS09960	COG2839	Protein conserved in bacteria
K6T24_RS09965	COG1253	flavin adenine dinucleotide binding
K6T24_RS09980	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS09985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6T24_RS10005	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS10015	COG1876	peptidase activity
K6T24_RS10025	COG0154	amidase activity
K6T24_RS10030	COG2211	Major facilitator Superfamily
K6T24_RS10045	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS10055	COG0561	phosphatase activity
K6T24_RS10060	COG1846	Transcriptional regulator
K6T24_RS10065	COG2814	Major facilitator Superfamily
K6T24_RS10075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K6T24_RS10090	COG1819	glycosyl
K6T24_RS10095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS10100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS10130	COG0456	acetyltransferase
K6T24_RS10225	COG3874	Sporulation protein YtfJ
K6T24_RS10250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6T24_RS10270	COG0346	lactoylglutathione lyase activity
K6T24_RS10305	COG0426	domain, Protein
K6T24_RS10305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6T24_RS10315	COG0386	Belongs to the glutathione peroxidase family
K6T24_RS10320	COG1305	Transglutaminase-like
K6T24_RS10325	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K6T24_RS10330	COG0714	Associated with various cellular activities
K6T24_RS10335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K6T24_RS10340	COG1140	nitrate reductase beta subunit
K6T24_RS10345	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K6T24_RS10350	COG2181	nitrate reductase activity
K6T24_RS10355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS10360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6T24_RS10365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6T24_RS10370	COG0303	'Molybdopterin
K6T24_RS10375	COG0314	molybdopterin synthase activity
K6T24_RS10385	COG2223	nitrite transmembrane transporter activity
K6T24_RS10410	COG1648	precorrin-2 dehydrogenase activity
K6T24_RS10420	COG1587	Uroporphyrinogen-III synthase
K6T24_RS10420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K6T24_RS10425	COG2146	nitrite reductase [NAD(P)H] activity
K6T24_RS10430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6T24_RS10445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS10450	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
K6T24_RS10475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS10525	COG2359	stage V sporulation protein S
K6T24_RS10535	COG1418	mRNA catabolic process
K6T24_RS10540	COG0488	(ABC) transporter
K6T24_RS10635	COG1413	lyase activity
K6T24_RS10650	COG2521	methyltransferase
K6T24_RS10650	COG2136	Putative SAM-dependent methyltransferase
K6T24_RS10655	COG0018	arginyl-trna synthetase
K6T24_RS10660	COG4106	trans-aconitate 2-methyltransferase activity
K6T24_RS10695	COG0017	Asparaginyl-tRNA synthetase
K6T24_RS10700	COG0733	neurotransmitter:sodium symporter activity
K6T24_RS10725	COG2610	gluconate transmembrane transporter activity
K6T24_RS10735	COG1794	racemase activity, acting on amino acids and derivatives
K6T24_RS10745	COG0456	acetyltransferase
K6T24_RS10750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K6T24_RS10760	COG1131	(ABC) transporter
K6T24_RS10765	COG4473	ABC transporter
K6T24_RS10775	COG0546	phosphoglycolate phosphatase activity
K6T24_RS10790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6T24_RS10805	COG0768	penicillin binding
K6T24_RS10815	COG0204	Acyl-transferase
K6T24_RS10820	COG1272	protein, Hemolysin III
K6T24_RS10830	COG0805	protein transport
K6T24_RS10840	COG1307	EDD domain protein, DegV family
K6T24_RS10845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6T24_RS10850	COG1999	signal sequence binding
K6T24_RS10855	COG0071	Belongs to the small heat shock protein (HSP20) family
K6T24_RS10860	COG0367	asparagine synthase
K6T24_RS10875	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS10880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6T24_RS10885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS10900	COG1335	isochorismatase
K6T24_RS10905	COG1051	belongs to the nudix hydrolase family
K6T24_RS10910	COG0668	transmembrane transport
K6T24_RS10915	COG2203	Gaf domain
K6T24_RS10915	COG4585	Histidine kinase
K6T24_RS10920	COG2197	response regulator
K6T24_RS10925	COG1737	Transcriptional regulator
K6T24_RS10930	COG1064	alcohol dehydrogenase
K6T24_RS10955	COG1070	Carbohydrate kinase
K6T24_RS10965	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K6T24_RS11000	COG1125	glycine betaine transport
K6T24_RS11000	COG0517	IMP dehydrogenase activity
K6T24_RS11005	COG1174	glycine betaine transport
K6T24_RS11040	COG1253	flavin adenine dinucleotide binding
K6T24_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS11050	COG5506	Protein of unknown function (DUF1694)
K6T24_RS11065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6T24_RS11070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K6T24_RS11075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K6T24_RS11080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6T24_RS11085	COG0456	acetyltransferase
K6T24_RS11090	COG3829	transcription factor binding
K6T24_RS11095	COG1509	lysine 2,3-aminomutase activity
K6T24_RS11130	COG3064	Membrane
K6T24_RS11130	COG4991	sh3 domain protein
K6T24_RS11130	COG0515	serine threonine protein kinase
K6T24_RS11140	COG0671	phosphoesterase, PA-phosphatase related
K6T24_RS11145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6T24_RS11150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6T24_RS11200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K6T24_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS11250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6T24_RS11250	COG4499	WXG100 protein secretion system (Wss), protein YukC
K6T24_RS11260	COG2814	Major facilitator Superfamily
K6T24_RS11270	COG0372	Belongs to the citrate synthase family
K6T24_RS11275	COG2079	MmgE PrpD family protein
K6T24_RS11280	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K6T24_RS11285	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS11290	COG2084	Dehydrogenase
K6T24_RS11300	COG1280	lysine exporter protein (LysE YggA)
K6T24_RS11305	COG1024	Enoyl-CoA hydratase
K6T24_RS11320	COG0420	3'-5' exonuclease activity
K6T24_RS11350	COG2223	nitrite transmembrane transporter activity
K6T24_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS11360	COG1169	isochorismate synthase
K6T24_RS11365	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6T24_RS11370	COG1535	isochorismatase
K6T24_RS11370	COG3433	isochorismatase activity
K6T24_RS11375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6T24_RS11380	COG3251	PFAM MbtH domain protein
K6T24_RS11385	COG2814	Major facilitator Superfamily
K6T24_RS11400	COG0776	regulation of translation
K6T24_RS11410	COG2318	DinB family
K6T24_RS11430	COG1115	amino acid carrier protein
K6T24_RS11445	COG2329	Antibiotic biosynthesis monooxygenase
K6T24_RS11450	COG1187	pseudouridine synthase activity
K6T24_RS11455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6T24_RS11460	COG1136	(ABC) transporter
K6T24_RS11470	COG0596	Alpha beta hydrolase
K6T24_RS11485	COG0028	Belongs to the TPP enzyme family
K6T24_RS11520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS11530	COG2207	Transcriptional regulator
K6T24_RS11555	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K6T24_RS11555	COG2755	lipolytic protein G-D-S-L family
K6T24_RS11565	COG5002	protein histidine kinase activity
K6T24_RS11575	COG0745	RESPONSE REGULATOR receiver
K6T24_RS11595	COG1846	Transcriptional regulator
K6T24_RS11605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS11610	COG1309	transcriptional regulator
K6T24_RS11635	COG1247	-acetyltransferase
K6T24_RS11660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K6T24_RS11670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS11700	COG0583	DNA-binding transcription factor activity
K6T24_RS11705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6T24_RS11710	COG0583	DNA-binding transcription factor activity
K6T24_RS11715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K6T24_RS11720	COG2258	MOSC domain
K6T24_RS11735	COG1132	(ABC) transporter
K6T24_RS11740	COG1132	(ABC) transporter
K6T24_RS11755	COG1396	sequence-specific DNA binding
K6T24_RS11800	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
K6T24_RS11805	COG1595	DNA-templated transcription, initiation
K6T24_RS11815	COG4122	O-methyltransferase activity
K6T24_RS11830	COG1649	PFAM Uncharacterised BCR, COG1649
K6T24_RS11850	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K6T24_RS11855	COG2971	BadF BadG BcrA BcrD
K6T24_RS11895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS11925	COG2226	methyltransferase
K6T24_RS11930	COG3961	Belongs to the TPP enzyme family
K6T24_RS11965	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6T24_RS11995	COG2002	toxin-antitoxin pair type II binding
K6T24_RS12005	COG0730	response to heat
K6T24_RS12015	COG1686	Belongs to the peptidase S11 family
K6T24_RS12035	COG0768	penicillin binding
K6T24_RS12040	COG1595	DNA-templated transcription, initiation
K6T24_RS12050	COG0768	penicillin binding
K6T24_RS12055	COG0768	penicillin binding
K6T24_RS12090	COG1404	Belongs to the peptidase S8 family
K6T24_RS12110	COG0697	spore germination
K6T24_RS12120	COG3397	chitin binding
K6T24_RS12125	COG0823	Involved in the tonB-independent uptake of proteins
K6T24_RS12150	COG0426	domain, Protein
K6T24_RS12155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6T24_RS12160	COG1773	rubredoxin
K6T24_RS12165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS12185	COG1131	(ABC) transporter
K6T24_RS12195	COG1309	transcriptional regulator
K6T24_RS12205	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS12210	COG0439	Biotin carboxylase
K6T24_RS12215	COG0511	ligase activity, forming carbon-carbon bonds
K6T24_RS12220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K6T24_RS12225	COG1024	Enoyl-CoA hydratase
K6T24_RS12230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K6T24_RS12235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6T24_RS12295	COG2318	DinB family
K6T24_RS12300	COG1686	Belongs to the peptidase S11 family
K6T24_RS12325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6T24_RS12345	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS12350	COG2207	Transcriptional regulator
K6T24_RS12380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6T24_RS12400	COG0789	Transcriptional regulator
K6T24_RS12410	COG1733	regulation of RNA biosynthetic process
K6T24_RS12415	COG2226	methyltransferase
K6T24_RS12425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6T24_RS12435	COG1942	4-Oxalocrotonate Tautomerase
K6T24_RS12440	COG0583	DNA-binding transcription factor activity
K6T24_RS12465	COG0697	spore germination
K6T24_RS12470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS12495	COG2323	membrane
K6T24_RS12505	COG0693	protein deglycase activity
K6T24_RS12515	COG3386	PFAM SMP-30 Gluconolaconase
K6T24_RS12525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
K6T24_RS12530	COG3773	Cell wall hydrolase
K6T24_RS12540	COG0745	RESPONSE REGULATOR receiver
K6T24_RS12545	COG2205	protein histidine kinase activity
K6T24_RS12555	COG0583	DNA-binding transcription factor activity
K6T24_RS12560	COG0667	Aldo Keto reductase
K6T24_RS12565	COG0488	(ABC) transporter
K6T24_RS12575	COG1136	(ABC) transporter
K6T24_RS12580	COG0577	efflux transmembrane transporter activity
K6T24_RS12605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS12615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K6T24_RS12775	COG2124	cytochrome p450
K6T24_RS12810	COG0561	phosphatase activity
K6T24_RS12845	COG5002	protein histidine kinase activity
K6T24_RS12850	COG0768	penicillin binding
K6T24_RS12860	COG1819	glycosyl
K6T24_RS12865	COG1794	racemase activity, acting on amino acids and derivatives
K6T24_RS12890	COG2205	protein histidine kinase activity
K6T24_RS12900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6T24_RS12905	COG0604	alcohol dehydrogenase
K6T24_RS12910	COG0671	phosphoesterase, PA-phosphatase related
K6T24_RS12915	COG0768	penicillin binding
K6T24_RS12975	COG2814	Major facilitator Superfamily
K6T24_RS12990	COG0584	glycerophosphoryl diester phosphodiesterase
K6T24_RS13015	COG0697	spore germination
K6T24_RS13050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6T24_RS13060	COG2223	nitrite transmembrane transporter activity
K6T24_RS13070	COG2816	NAD+ diphosphatase activity
K6T24_RS13075	COG0592	DNA-directed DNA polymerase activity
K6T24_RS13105	COG3878	Protein conserved in bacteria
K6T24_RS13130	COG4667	esterase of the alpha-beta hydrolase superfamily
K6T24_RS13170	COG0322	excinuclease ABC activity
K6T24_RS13200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6T24_RS13225	COG1011	Hydrolase
K6T24_RS13230	COG0745	RESPONSE REGULATOR receiver
K6T24_RS13235	COG5002	protein histidine kinase activity
K6T24_RS13265	COG1136	(ABC) transporter
K6T24_RS13270	COG0577	efflux transmembrane transporter activity
K6T24_RS13280	COG1073	alpha beta
K6T24_RS13285	COG0657	acetylesterase activity
K6T24_RS13290	COG0076	glutamate decarboxylase activity
K6T24_RS13305	COG1523	belongs to the glycosyl hydrolase 13 family
K6T24_RS13310	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS13315	COG0737	Belongs to the 5'-nucleotidase family
K6T24_RS13325	COG0201	protein transport
K6T24_RS13330	COG0697	spore germination
K6T24_RS13335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS13370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS13385	COG2959	enzyme of heme biosynthesis
K6T24_RS13425	COG1309	transcriptional regulator
K6T24_RS13435	COG3284	Transcriptional regulator
K6T24_RS13450	COG1349	DNA-binding transcription factor activity
K6T24_RS13470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6T24_RS13475	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6T24_RS13480	COG0022	dehydrogenase e1 component
K6T24_RS13485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6T24_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS13525	COG4176	ABC-type proline glycine betaine transport system permease component
K6T24_RS13530	COG0517	IMP dehydrogenase activity
K6T24_RS13530	COG4175	Glycine betaine
K6T24_RS13560	COG2153	protein acetylation
K6T24_RS13575	COG3397	chitin binding
K6T24_RS13585	COG1819	glycosyl
K6T24_RS13605	COG2205	protein histidine kinase activity
K6T24_RS13610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K6T24_RS13615	COG2315	Protein conserved in bacteria
K6T24_RS13665	COG3973	AAA domain
K6T24_RS13675	COG0514	ATP-dependent DNA helicase (RecQ)
K6T24_RS13710	COG4637	Psort location Cytoplasmic, score
K6T24_RS13725	COG3397	chitin binding
K6T24_RS13730	COG2318	DinB family
K6T24_RS13745	COG1162	GTPase activity
K6T24_RS13750	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K6T24_RS13755	COG1115	amino acid carrier protein
K6T24_RS13760	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS13765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K6T24_RS13770	COG3938	Belongs to the proline racemase family
K6T24_RS13775	COG3938	Belongs to the proline racemase family
K6T24_RS13780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6T24_RS13830	COG1078	dGTPase activity
K6T24_RS13835	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS13845	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K6T24_RS13850	COG4166	transmembrane transport
K6T24_RS13860	COG4948	Mandelate Racemase Muconate Lactonizing
K6T24_RS13910	COG2936	dipeptidyl-peptidase activity
K6T24_RS13915	COG3850	Histidine kinase
K6T24_RS13915	COG5002	protein histidine kinase activity
K6T24_RS13920	COG0745	RESPONSE REGULATOR receiver
K6T24_RS13945	COG1164	Oligoendopeptidase f
K6T24_RS13950	COG0456	acetyltransferase
K6T24_RS13955	COG1307	EDD domain protein, DegV family
K6T24_RS13980	COG1335	isochorismatase
K6T24_RS13995	COG2814	Major facilitator Superfamily
K6T24_RS14005	COG1664	Polymer-forming cytoskeletal
K6T24_RS14010	COG0789	Transcriptional regulator
K6T24_RS14015	COG4533	DNA binding
K6T24_RS14020	COG0477	Major facilitator Superfamily
K6T24_RS14020	COG2814	Major facilitator Superfamily
K6T24_RS14045	COG2261	transglycosylase associated protein
K6T24_RS14060	COG2226	methyltransferase
K6T24_RS14095	COG0436	Aminotransferase
K6T24_RS14100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K6T24_RS14110	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K6T24_RS14125	COG1131	(ABC) transporter
K6T24_RS14170	COG0628	permease
K6T24_RS14185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6T24_RS14190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6T24_RS14195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6T24_RS14225	COG2746	aminoglycoside 3-N-acetyltransferase activity
K6T24_RS14255	COG0697	spore germination
K6T24_RS14260	COG2318	DinB family
K6T24_RS14290	COG0346	lactoylglutathione lyase activity
K6T24_RS14295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS14320	COG2814	Major facilitator Superfamily
K6T24_RS14325	COG0861	Integral membrane protein TerC family
K6T24_RS14330	COG1368	sulfuric ester hydrolase activity
K6T24_RS14335	COG0488	(ABC) transporter
K6T24_RS14340	COG1033	growth of symbiont in host cell
K6T24_RS14340	COG2409	Drug exporters of the RND superfamily
K6T24_RS14345	COG1309	transcriptional regulator
K6T24_RS14360	COG0287	Prephenate dehydrogenase
K6T24_RS14375	COG1605	Chorismate mutase
K6T24_RS14375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K6T24_RS14415	COG1388	LysM domain
K6T24_RS14415	COG3584	3D domain protein
K6T24_RS14425	COG0346	lactoylglutathione lyase activity
K6T24_RS14430	COG0519	Catalyzes the synthesis of GMP from XMP
K6T24_RS14435	COG0431	NADPH-dependent FMN reductase
K6T24_RS14455	COG1879	ABC-type sugar transport system periplasmic component
K6T24_RS14460	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS14465	COG1172	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS14475	COG2390	Transcriptional regulator
K6T24_RS14510	COG2329	Antibiotic biosynthesis monooxygenase
K6T24_RS14530	COG1472	Belongs to the glycosyl hydrolase 3 family
K6T24_RS14535	COG2207	Transcriptional regulator
K6T24_RS14540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS14550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K6T24_RS14555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6T24_RS14560	COG4187	Peptidase family M20/M25/M40
K6T24_RS14565	COG1414	Transcriptional regulator
K6T24_RS14570	COG0833	amino acid
K6T24_RS14580	COG3239	Fatty acid desaturase
K6T24_RS14590	COG1785	Belongs to the alkaline phosphatase family
K6T24_RS14600	COG3655	Transcriptional regulator
K6T24_RS14625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS14630	COG0346	lactoylglutathione lyase activity
K6T24_RS14650	COG0714	Associated with various cellular activities
K6T24_RS14675	COG0753	catalase activity
K6T24_RS14715	COG0714	Associated with various cellular activities
K6T24_RS14760	COG0778	Nitroreductase
K6T24_RS14765	COG1846	Transcriptional regulator
K6T24_RS14785	COG0179	Fumarylacetoacetate (FAA) hydrolase
K6T24_RS14805	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS14810	COG0183	Belongs to the thiolase family
K6T24_RS14815	COG1024	Enoyl-CoA hydratase
K6T24_RS14820	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6T24_RS14825	COG2723	6-phospho-beta-galactosidase activity
K6T24_RS14830	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6T24_RS14835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6T24_RS14850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6T24_RS14860	COG2508	Transcriptional regulator
K6T24_RS14865	COG2814	Major facilitator Superfamily
K6T24_RS14880	COG4884	unkown
K6T24_RS14880	COG3831	ATPase activity
K6T24_RS14915	COG0456	acetyltransferase
K6T24_RS14930	COG0697	spore germination
K6T24_RS14935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS14955	COG0642	Histidine kinase
K6T24_RS14960	COG0745	RESPONSE REGULATOR receiver
K6T24_RS14965	COG0596	Alpha beta hydrolase
K6T24_RS14995	COG0730	response to heat
K6T24_RS15005	COG0833	amino acid
K6T24_RS15015	COG4335	DNA alkylation repair
K6T24_RS15045	COG0768	penicillin binding
K6T24_RS15075	COG1984	allophanate hydrolase subunit 2
K6T24_RS15080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K6T24_RS15085	COG1414	Transcriptional regulator
K6T24_RS15110	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS15125	COG3314	Sporulation integral membrane protein YlbJ
K6T24_RS15155	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K6T24_RS15175	COG3848	Pyruvate phosphate dikinase
K6T24_RS15175	COG0574	Belongs to the PEP-utilizing enzyme family
K6T24_RS15205	COG1999	signal sequence binding
K6T24_RS15210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K6T24_RS15215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K6T24_RS15230	COG0798	PFAM Bile acid sodium symporter
K6T24_RS15235	COG0346	lactoylglutathione lyase activity
K6T24_RS15240	COG0640	Transcriptional regulator
K6T24_RS15250	COG2814	Major facilitator Superfamily
K6T24_RS15260	COG1309	transcriptional regulator
K6T24_RS15265	COG2186	Transcriptional regulator
K6T24_RS15280	COG0814	amino acid
K6T24_RS15285	COG0697	spore germination
K6T24_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS15300	COG1522	sequence-specific DNA binding
K6T24_RS15315	COG0346	lactoylglutathione lyase activity
K6T24_RS15390	COG0384	phenazine biosynthesis protein PhzF
K6T24_RS15395	COG2814	Major facilitator Superfamily
K6T24_RS15400	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K6T24_RS15415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K6T24_RS15435	COG0577	efflux transmembrane transporter activity
K6T24_RS15455	COG5002	protein histidine kinase activity
K6T24_RS15455	COG3850	Histidine kinase
K6T24_RS15465	COG2364	Membrane
K6T24_RS15470	COG1846	Transcriptional regulator
K6T24_RS15475	COG0456	acetyltransferase
K6T24_RS15480	COG2808	Putative FMN-binding domain
K6T24_RS15485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS15500	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6T24_RS15520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K6T24_RS15570	COG2814	Major facilitator Superfamily
K6T24_RS15650	COG1876	peptidase activity
K6T24_RS15655	COG2843	Capsule synthesis protein
K6T24_RS15665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6T24_RS15670	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS15680	COG0534	Mate efflux family protein
K6T24_RS15685	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS15690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K6T24_RS15705	COG0477	Major facilitator Superfamily
K6T24_RS15720	COG1846	Transcriptional regulator
K6T24_RS15725	COG2814	Major facilitator Superfamily
K6T24_RS15745	COG1136	(ABC) transporter
K6T24_RS15770	COG2031	fatty acid transporter
K6T24_RS15780	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6T24_RS15835	COG1288	antiporter activity
K6T24_RS15840	COG2356	endonuclease I
K6T24_RS15850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6T24_RS15855	COG1902	pentaerythritol trinitrate reductase activity
K6T24_RS15860	COG0583	DNA-binding transcription factor activity
K6T24_RS15865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K6T24_RS15885	COG1733	regulation of RNA biosynthetic process
K6T24_RS15890	COG0778	Nitroreductase
K6T24_RS15920	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS15930	COG1131	(ABC) transporter
K6T24_RS15955	COG1011	Hydrolase
K6T24_RS15965	COG2365	Tyrosine phosphatase family
K6T24_RS16015	COG0628	permease
K6T24_RS16045	COG0477	Major facilitator Superfamily
K6T24_RS16065	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K6T24_RS16075	COG1253	flavin adenine dinucleotide binding
K6T24_RS16080	COG0789	Transcriptional regulator
K6T24_RS16115	COG0697	spore germination
K6T24_RS16120	COG1357	PFAM Pentapeptide repeats (8 copies)
K6T24_RS16125	COG3813	Protein conserved in bacteria
K6T24_RS16130	COG2706	6-phosphogluconolactonase activity
K6T24_RS16135	COG1070	Carbohydrate kinase
K6T24_RS16150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K6T24_RS16160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6T24_RS16165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K6T24_RS16170	COG0604	alcohol dehydrogenase
K6T24_RS16175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K6T24_RS16180	COG0789	Transcriptional regulator
K6T24_RS16185	COG4221	oxidoreductase activity
K6T24_RS16205	COG0656	L-ascorbic acid biosynthetic process
K6T24_RS16210	COG2814	Major facilitator Superfamily
K6T24_RS16225	COG0346	lactoylglutathione lyase activity
K6T24_RS16230	COG0814	amino acid
K6T24_RS16235	COG3655	Transcriptional regulator
K6T24_RS16265	COG1393	Belongs to the ArsC family
K6T24_RS16270	COG1733	regulation of RNA biosynthetic process
K6T24_RS16275	COG2188	Transcriptional regulator
K6T24_RS16280	COG0673	inositol 2-dehydrogenase activity
K6T24_RS16285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K6T24_RS16290	COG1733	regulation of RNA biosynthetic process
K6T24_RS16295	COG1733	regulation of RNA biosynthetic process
K6T24_RS16315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS16345	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS16350	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6T24_RS16355	COG1733	regulation of RNA biosynthetic process
K6T24_RS16385	COG1191	sigma factor activity
K6T24_RS16400	COG3226	Transcriptional regulator
K6T24_RS16405	COG1280	lysine exporter protein (LysE YggA)
K6T24_RS16445	COG1151	hydroxylamine reductase activity
K6T24_RS16450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS16455	COG3409	Peptidoglycan-binding domain 1 protein
K6T24_RS16455	COG3757	hydrolase, family 25
K6T24_RS16490	COG2072	flavoprotein involved in K transport
K6T24_RS16530	COG0604	alcohol dehydrogenase
K6T24_RS16535	COG1113	amino acid transport
K6T24_RS16540	COG2814	Major facilitator Superfamily
K6T24_RS16590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6T24_RS16595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6T24_RS16605	COG1247	-acetyltransferase
K6T24_RS16610	COG3739	integral membrane protein
K6T24_RS16640	COG0583	DNA-binding transcription factor activity
K6T24_RS16650	COG2890	protein-(glutamine-N5) methyltransferase activity
K6T24_RS16665	COG1193	negative regulation of DNA recombination
K6T24_RS16685	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K6T24_RS16690	COG1164	Oligoendopeptidase f
K6T24_RS16715	COG3781	membrane
K6T24_RS16730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K6T24_RS16755	COG0584	glycerophosphoryl diester phosphodiesterase
K6T24_RS16765	COG0640	Transcriptional regulator
K6T24_RS16770	COG0604	alcohol dehydrogenase
K6T24_RS16800	COG0277	FAD linked oxidase domain protein
K6T24_RS16840	COG3852	Histidine kinase
K6T24_RS16850	COG1285	pathogenesis
K6T24_RS16865	COG2720	vancomycin resistance protein
K6T24_RS16900	COG0716	FMN binding
K6T24_RS16930	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS16940	COG0165	Argininosuccinate lyase
K6T24_RS16955	COG4145	pantothenate transmembrane transporter activity
K6T24_RS16965	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS16980	COG1657	PFAM Prenyltransferase squalene oxidase
K6T24_RS16985	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K6T24_RS16990	COG2962	Rard protein
K6T24_RS16995	COG3326	Membrane
K6T24_RS17010	COG0489	protein tyrosine kinase activity
K6T24_RS17020	COG0314	molybdopterin synthase activity
K6T24_RS17025	COG0303	'Molybdopterin
K6T24_RS17030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6T24_RS17035	COG2116	formate transmembrane transporter activity
K6T24_RS17045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K6T24_RS17050	COG5609	conserved protein (DUF2294)
K6T24_RS17055	COG2427	Protein of unknown function (DUF1641)
K6T24_RS17060	COG3383	formate dehydrogenase (NAD+) activity
K6T24_RS17075	COG0531	amino acid
K6T24_RS17110	COG2226	methyltransferase
K6T24_RS17115	COG4166	transmembrane transport
K6T24_RS17120	COG4166	transmembrane transport
K6T24_RS17125	COG4166	transmembrane transport
K6T24_RS17135	COG1316	TRANSCRIPTIONal
K6T24_RS17145	COG1595	DNA-templated transcription, initiation
K6T24_RS17155	COG1131	(ABC) transporter
K6T24_RS17165	COG0673	inositol 2-dehydrogenase activity
K6T24_RS17170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K6T24_RS17175	COG0187	DNA topoisomerase II activity
K6T24_RS17180	COG1832	CoA-binding protein
K6T24_RS17185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6T24_RS17190	COG0745	RESPONSE REGULATOR receiver
K6T24_RS17200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K6T24_RS17200	COG1328	CTP reductase activity
K6T24_RS17210	COG4841	protein insertion into membrane
K6T24_RS17215	COG0824	Thioesterase
K6T24_RS17245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6T24_RS17255	COG2274	protein secretion by the type I secretion system
K6T24_RS17260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K6T24_RS17290	COG2211	Major facilitator Superfamily
K6T24_RS17300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K6T24_RS17315	COG0183	Belongs to the thiolase family
K6T24_RS17320	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS17325	COG1268	BioY protein
K6T24_RS17330	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS17335	COG1396	sequence-specific DNA binding
K6T24_RS17375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS17385	COG5002	protein histidine kinase activity
K6T24_RS17390	COG0400	carboxylic ester hydrolase activity
K6T24_RS17395	COG0346	lactoylglutathione lyase activity
K6T24_RS17400	COG0069	glutamate synthase activity
K6T24_RS17405	COG1902	pentaerythritol trinitrate reductase activity
K6T24_RS17410	COG1329	Transcriptional regulator
K6T24_RS17415	COG0010	Belongs to the arginase family
K6T24_RS17465	COG4846	Membrane protein involved in cytochrome C biogenesis
K6T24_RS17470	COG0785	Cytochrome C biogenesis protein
K6T24_RS17480	COG1473	amidohydrolase
K6T24_RS17490	COG1131	(ABC) transporter
K6T24_RS17505	COG0583	DNA-binding transcription factor activity
K6T24_RS17515	COG1346	cytolysis
K6T24_RS17530	COG0730	response to heat
K6T24_RS17555	COG1132	(ABC) transporter
K6T24_RS17560	COG1132	(ABC) transporter
K6T24_RS17565	COG3763	UPF0154 protein
K6T24_RS17585	COG3639	organic phosphonate transmembrane transporter activity
K6T24_RS17600	COG0737	Belongs to the 5'-nucleotidase family
K6T24_RS17610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K6T24_RS17630	COG1695	Transcriptional regulator
K6T24_RS17635	COG1132	(ABC) transporter
K6T24_RS17665	COG0367	asparagine synthase
K6T24_RS17680	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6T24_RS17685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6T24_RS17690	COG3420	alginic acid biosynthetic process
K6T24_RS17690	COG5434	Belongs to the glycosyl hydrolase 28 family
K6T24_RS17715	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS17725	COG0463	Glycosyl transferase, family 2
K6T24_RS17725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K6T24_RS17730	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS17735	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS17740	COG1086	Polysaccharide biosynthesis protein
K6T24_RS17745	COG0489	protein tyrosine kinase activity
K6T24_RS17765	COG1196	nuclear chromosome segregation
K6T24_RS17765	COG0739	heme binding
K6T24_RS17765	COG0741	lytic transglycosylase activity
K6T24_RS17770	COG0741	lytic transglycosylase activity
K6T24_RS17800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K6T24_RS17805	COG0174	glutamine synthetase
K6T24_RS17810	COG0789	Transcriptional regulator
K6T24_RS17815	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K6T24_RS17820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K6T24_RS17825	COG2860	membrane
K6T24_RS17835	COG0464	growth
K6T24_RS17875	COG3584	3D domain protein
K6T24_RS17875	COG1388	LysM domain
K6T24_RS17880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6T24_RS17880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6T24_RS17880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K6T24_RS17885	COG1105	Belongs to the carbohydrate kinase PfkB family
K6T24_RS17890	COG1349	DNA-binding transcription factor activity
K6T24_RS17895	COG1979	alcohol dehydrogenase
K6T24_RS17900	COG2322	membrane
K6T24_RS17910	COG1113	amino acid transport
K6T24_RS17920	COG1473	amidohydrolase
K6T24_RS17925	COG1408	metallophosphoesterase
K6T24_RS17945	COG2217	Heavy metal translocating P-type atpase
K6T24_RS17950	COG2608	mercury ion transmembrane transporter activity
K6T24_RS17955	COG1937	Protein conserved in bacteria
K6T24_RS17975	COG2819	hydrolase of the alpha beta superfamily
K6T24_RS17980	COG1120	ATPase activity
K6T24_RS17985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS17990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS17995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6T24_RS18000	COG0708	Exodeoxyribonuclease III
K6T24_RS18005	COG2169	Transcriptional regulator
K6T24_RS18010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K6T24_RS18015	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K6T24_RS18025	COG2364	Membrane
K6T24_RS18045	COG5001	Diguanylate cyclase
K6T24_RS18045	COG3300	MHYT domain
K6T24_RS18085	COG1346	cytolysis
K6T24_RS18095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K6T24_RS18100	COG0596	Alpha beta hydrolase
K6T24_RS18100	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6T24_RS18105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K6T24_RS18125	COG1404	Belongs to the peptidase S8 family
K6T24_RS18130	COG3773	Cell wall hydrolase
K6T24_RS18140	COG1368	sulfuric ester hydrolase activity
K6T24_RS18175	COG4550	Control of competence regulator ComK, YlbF/YmcA
K6T24_RS18185	COG1013	pyruvate-flavodoxin oxidoreductase activity
K6T24_RS18190	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K6T24_RS18190	COG0674	pyruvate-flavodoxin oxidoreductase activity
K6T24_RS18200	COG2359	stage V sporulation protein S
K6T24_RS18205	COG1692	metallophosphoesterase
K6T24_RS18225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K6T24_RS18230	COG1426	Protein conserved in bacteria
K6T24_RS18245	COG0300	oxidoreductase activity
K6T24_RS18250	COG0612	Peptidase, M16
K6T24_RS18255	COG0612	Peptidase, M16
K6T24_RS18260	COG1079	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS18265	COG4603	Belongs to the binding-protein-dependent transport system permease family
K6T24_RS18270	COG3845	ABC transporter
K6T24_RS18275	COG1744	ABC transporter substrate-binding protein PnrA-like
K6T24_RS18280	COG2188	Transcriptional regulator
K6T24_RS18285	COG1674	ftsk spoiiie
K6T24_RS18295	COG0740	serine-type endopeptidase activity
K6T24_RS18300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6T24_RS18310	COG0527	aspartate kinase activity
K6T24_RS18315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K6T24_RS18320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6T24_RS18325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6T24_RS18330	COG1873	PFAM PRC-barrel domain
K6T24_RS18335	COG0612	Peptidase, M16
K6T24_RS18340	COG0726	polysaccharide deacetylase
K6T24_RS18355	COG0196	riboflavin kinase activity
K6T24_RS18365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K6T24_RS18370	COG1550	Protein conserved in bacteria
K6T24_RS18380	COG1358	cellular component organization or biogenesis
K6T24_RS18385	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K6T24_RS18390	COG0195	Participates in both transcription termination and antitermination
K6T24_RS18410	COG0750	zinc metalloprotease
K6T24_RS18420	COG4589	Belongs to the CDS family
K6T24_RS18435	COG0528	UMP kinase activity
K6T24_RS18440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K6T24_RS18465	COG4974	Belongs to the 'phage' integrase family
K6T24_RS18475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6T24_RS18480	COG0758	DNA mediated transformation
K6T24_RS18485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K6T24_RS18510	COG0335	large ribosomal subunit rRNA binding
K6T24_RS18525	COG1837	Belongs to the UPF0109 family
K6T24_RS18535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K6T24_RS18545	COG0552	protein localization to endoplasmic reticulum
K6T24_RS18550	COG1196	nuclear chromosome segregation
K6T24_RS18560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6T24_RS18565	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS18570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K6T24_RS18585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K6T24_RS18590	COG1461	Dihydroxyacetone kinase
K6T24_RS18595	COG1302	Protein conserved in bacteria
K6T24_RS18610	COG1564	THIamine pyrophosphokinase
K6T24_RS18615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K6T24_RS18620	COG1162	GTPase activity
K6T24_RS18625	COG0515	serine threonine protein kinase
K6T24_RS18625	COG2815	serine threonine protein kinase
K6T24_RS18630	COG0631	protein serine/threonine phosphatase activity
K6T24_RS18640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K6T24_RS18640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6T24_RS18645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6T24_RS18655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K6T24_RS18660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K6T24_RS18680	COG1561	YicC-like family, N-terminal region
K6T24_RS18685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K6T24_RS18695	COG0006	proline dipeptidase activity
K6T24_RS18715	COG3069	C4-dicarboxylate transmembrane transporter activity
K6T24_RS18775	COG0564	pseudouridine synthase activity
K6T24_RS18795	COG3599	regulation of cell shape
K6T24_RS18800	COG2302	S4 RNA-binding domain
K6T24_RS18805	COG0762	integral membrane protein
K6T24_RS18815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K6T24_RS18825	COG1873	PFAM PRC-barrel domain
K6T24_RS18830	COG1191	sigma factor activity
K6T24_RS18835	COG1191	sigma factor activity
K6T24_RS18845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6T24_RS18850	COG0849	cell division
K6T24_RS18855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K6T24_RS18870	COG0772	Belongs to the SEDS family
K6T24_RS18890	COG0768	penicillin binding
K6T24_RS18895	COG0768	penicillin binding
K6T24_RS18915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K6T24_RS18930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K6T24_RS18935	COG1399	metal-binding, possibly nucleic acid-binding protein
K6T24_RS18945	COG3480	Lon protease (S16) C-terminal proteolytic domain
K6T24_RS18950	COG1752	Esterase of the alpha-beta hydrolase superfamily
K6T24_RS18955	COG3314	Sporulation integral membrane protein YlbJ
K6T24_RS18965	COG0742	ribosomal rna small subunit methyltransferase
K6T24_RS18980	COG3679	Belongs to the UPF0342 family
K6T24_RS18985	COG0406	alpha-ribazole phosphatase activity
K6T24_RS19000	COG2340	Cysteine-rich secretory protein family
K6T24_RS19015	COG3336	cytochrome c oxidase
K6T24_RS19050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K6T24_RS19055	COG0772	Belongs to the SEDS family
K6T24_RS19065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K6T24_RS19070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K6T24_RS19080	COG4896	Protein conserved in bacteria
K6T24_RS19095	COG1217	gtp-binding protein TYPA
K6T24_RS19105	COG0483	inositol monophosphate 1-phosphatase activity
K6T24_RS19125	COG1982	Orn Lys Arg decarboxylase major
K6T24_RS19185	COG0022	dehydrogenase e1 component
K6T24_RS19190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6T24_RS19205	COG0561	phosphatase activity
K6T24_RS19210	COG5503	Protein of unknown function (DUF1447)
K6T24_RS19215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K6T24_RS19220	COG0569	domain protein
K6T24_RS19235	COG2171	N-acyltransferase activity
K6T24_RS19240	COG0583	DNA-binding transcription factor activity
K6T24_RS19245	COG0517	IMP dehydrogenase activity
K6T24_RS19255	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K6T24_RS19265	COG4703	Protein of unknown function (DUF1797)
K6T24_RS19285	COG2200	EAL domain
K6T24_RS19290	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS19295	COG1408	metallophosphoesterase
K6T24_RS19305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K6T24_RS19340	COG2814	Major facilitator Superfamily
K6T24_RS19360	COG3209	COG3209 Rhs family protein
K6T24_RS19370	COG2205	protein histidine kinase activity
K6T24_RS19380	COG0436	Aminotransferase
K6T24_RS19385	COG1609	Transcriptional regulator
K6T24_RS19390	COG3833	ABC-type maltose transport systems, permease component
K6T24_RS19395	COG1175	transmembrane transport
K6T24_RS19400	COG2182	Extracellular solute-binding protein
K6T24_RS19410	COG0366	Alpha amylase catalytic
K6T24_RS19415	COG3842	ATPase activity
K6T24_RS19455	COG0183	Belongs to the thiolase family
K6T24_RS19460	COG0494	nUDIX hydrolase
K6T24_RS19490	COG1695	Transcriptional regulator
K6T24_RS19495	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS19515	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K6T24_RS19520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K6T24_RS19525	COG0436	Aminotransferase
K6T24_RS19560	COG2084	Dehydrogenase
K6T24_RS19570	COG2199	diguanylate cyclase activity
K6T24_RS19575	COG0778	Nitroreductase
K6T24_RS19600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS19600	COG2190	(PTS) system
K6T24_RS19600	COG1263	PTS System
K6T24_RS19605	COG3711	transcriptional antiterminator
K6T24_RS19615	COG2188	Transcriptional regulator
K6T24_RS19625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K6T24_RS19650	COG1547	Domain of unknown function (DUF309)
K6T24_RS19655	COG0456	acetyltransferase
K6T24_RS19660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K6T24_RS19665	COG4086	secreted protein
K6T24_RS19670	COG0561	phosphatase activity
K6T24_RS19675	COG0697	spore germination
K6T24_RS19690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6T24_RS19715	COG0733	neurotransmitter:sodium symporter activity
K6T24_RS19735	COG1686	Belongs to the peptidase S11 family
K6T24_RS19740	COG1725	Transcriptional regulator
K6T24_RS19745	COG1131	(ABC) transporter
K6T24_RS19760	COG1846	Transcriptional regulator
K6T24_RS19775	COG0598	Magnesium transport protein CorA
K6T24_RS19800	COG4974	Belongs to the 'phage' integrase family
K6T24_RS19810	COG0735	belongs to the Fur family
K6T24_RS19815	COG1300	Membrane
K6T24_RS19835	COG0667	Aldo Keto reductase
K6T24_RS19840	COG0656	L-ascorbic acid biosynthetic process
K6T24_RS19845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K6T24_RS19845	COG0456	acetyltransferase
K6T24_RS19855	COG4085	toxin activity
K6T24_RS19855	COG0737	Belongs to the 5'-nucleotidase family
K6T24_RS19855	COG1525	nuclease
K6T24_RS19865	COG0596	Alpha beta hydrolase
K6T24_RS19870	COG2056	Na+-H+ antiporter family
K6T24_RS19875	COG1609	Transcriptional regulator
K6T24_RS19880	COG0456	acetyltransferase
K6T24_RS19885	COG1073	alpha beta
K6T24_RS19900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6T24_RS19900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K6T24_RS19905	COG0307	riboflavin synthase, alpha
K6T24_RS19930	COG4106	trans-aconitate 2-methyltransferase activity
K6T24_RS19935	COG1073	alpha beta
K6T24_RS19935	COG2226	methyltransferase
K6T24_RS19950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K6T24_RS19960	COG1757	Na H antiporter
K6T24_RS19965	COG0737	Belongs to the 5'-nucleotidase family
K6T24_RS19975	COG1522	sequence-specific DNA binding
K6T24_RS20010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K6T24_RS20020	COG0300	oxidoreductase activity
K6T24_RS20025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS20030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6T24_RS20035	COG1760	l-serine dehydratase
K6T24_RS20040	COG1760	l-serine dehydratase
K6T24_RS20070	COG1285	pathogenesis
K6T24_RS20085	COG2195	Cleaves the N-terminal amino acid of tripeptides
K6T24_RS20090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS20105	COG1376	ErfK ybiS ycfS ynhG family protein
K6T24_RS20110	COG4129	membrane
K6T24_RS20115	COG1126	abc transporter atp-binding protein
K6T24_RS20120	COG0765	amino acid transport
K6T24_RS20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K6T24_RS20140	COG2816	NAD+ diphosphatase activity
K6T24_RS20145	COG2323	membrane
K6T24_RS20150	COG0772	Belongs to the SEDS family
K6T24_RS20155	COG0508	dehydrogenase complex catalyzes the overall conversion of
K6T24_RS20160	COG0022	dehydrogenase e1 component
K6T24_RS20165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K6T24_RS20170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K6T24_RS20185	COG0280	phosphate acetyltransferase
K6T24_RS20190	COG3290	protein histidine kinase activity
K6T24_RS20190	COG3829	transcription factor binding
K6T24_RS20200	COG0584	glycerophosphoryl diester phosphodiesterase
K6T24_RS20205	COG3093	addiction module antidote protein HigA
K6T24_RS20210	COG1215	transferase activity, transferring glycosyl groups
K6T24_RS20255	COG0457	Tetratricopeptide repeat
K6T24_RS20290	COG0745	RESPONSE REGULATOR receiver
K6T24_RS20295	COG0750	zinc metalloprotease
K6T24_RS20300	COG0497	DNA recombination
K6T24_RS20310	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K6T24_RS20320	COG0142	geranyltranstransferase activity
K6T24_RS20340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K6T24_RS20345	COG1302	Protein conserved in bacteria
K6T24_RS20350	COG0439	Biotin carboxylase
K6T24_RS20355	COG0511	ligase activity, forming carbon-carbon bonds
K6T24_RS20400	COG3854	ATPases associated with a variety of cellular activities
K6T24_RS20425	COG0006	proline dipeptidase activity
K6T24_RS20440	COG3872	metal-dependent enzyme
K6T24_RS20450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K6T24_RS20480	COG0095	Lipoate-protein ligase
K6T24_RS20485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS20495	COG1609	Transcriptional regulator
K6T24_RS20505	COG2076	Multidrug Resistance protein
K6T24_RS20510	COG2076	Multidrug Resistance protein
K6T24_RS20540	COG1131	(ABC) transporter
K6T24_RS20545	COG1725	Transcriptional regulator
K6T24_RS20560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K6T24_RS20570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K6T24_RS20575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6T24_RS20630	COG4970	Tfp pilus assembly protein FimT
K6T24_RS20640	COG1459	type II secretion system
K6T24_RS20760	COG0646	methionine synthase
K6T24_RS20760	COG1410	methionine synthase
K6T24_RS20765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K6T24_RS20765	COG0646	methionine synthase
K6T24_RS20770	COG0626	cystathionine gamma-synthase activity
K6T24_RS20775	COG0626	cystathionine gamma-synthase activity
K6T24_RS20805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS20815	COG1940	carbohydrate kinase activity
K6T24_RS20820	COG4483	Protein conserved in bacteria
K6T24_RS20825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K6T24_RS20830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K6T24_RS20835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K6T24_RS20840	COG0704	Plays a role in the regulation of phosphate uptake
K6T24_RS20850	COG0581	inorganic phosphate transmembrane transporter activity
K6T24_RS20855	COG0573	inorganic phosphate transmembrane transporter activity
K6T24_RS20860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K6T24_RS20865	COG0768	penicillin binding
K6T24_RS20870	COG0477	Major facilitator Superfamily
K6T24_RS20875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6T24_RS20900	COG0735	belongs to the Fur family
K6T24_RS20905	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K6T24_RS20910	COG1121	(ABC) transporter
K6T24_RS20915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS20945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K6T24_RS20950	COG2384	SAM-dependent methyltransferase
K6T24_RS20955	COG2010	Cytochrome c
K6T24_RS20960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6T24_RS20965	COG0358	DNA primase activity
K6T24_RS20970	COG1671	Belongs to the UPF0178 family
K6T24_RS20980	COG0517	IMP dehydrogenase activity
K6T24_RS20995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K6T24_RS21000	COG0295	cytidine deaminase activity
K6T24_RS21005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K6T24_RS21010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K6T24_RS21015	COG1480	7TM receptor with intracellular HD hydrolase
K6T24_RS21020	COG1702	phosphate starvation-inducible protein PhoH
K6T24_RS21035	COG1610	YqeY-like protein
K6T24_RS21040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K6T24_RS21045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K6T24_RS21050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K6T24_RS21060	COG0484	heat shock protein binding
K6T24_RS21075	COG1420	regulation of RNA biosynthetic process
K6T24_RS21080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K6T24_RS21085	COG1733	regulation of RNA biosynthetic process
K6T24_RS21110	COG1466	dna polymerase III delta subunit
K6T24_RS21120	COG2333	competence protein COMEC
K6T24_RS21120	COG0658	competence protein
K6T24_RS21125	COG2131	deaminase
K6T24_RS21130	COG1596	polysaccharide export
K6T24_RS21130	COG1555	photosystem II stabilization
K6T24_RS21135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K6T24_RS21140	COG2226	methyltransferase
K6T24_RS21145	COG0799	negative regulation of ribosome biogenesis
K6T24_RS21150	COG1713	HD superfamily hydrolase involved in NAD metabolism
K6T24_RS21155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K6T24_RS21160	COG1534	Rna-binding protein
K6T24_RS21170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K6T24_RS21175	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K6T24_RS21210	COG0778	Nitroreductase
K6T24_RS21215	COG2357	RelA SpoT domain protein
K6T24_RS21225	COG1785	Belongs to the alkaline phosphatase family
K6T24_RS21235	COG2267	carboxylic ester hydrolase activity
K6T24_RS21280	COG1404	Belongs to the peptidase S8 family
K6T24_RS21285	COG3186	Phenylalanine-4-hydroxylase
K6T24_RS21295	COG2514	catechol 2,3-dioxygenase activity
K6T24_RS21300	COG2259	Doxx family
K6T24_RS21340	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6T24_RS21350	COG1012	belongs to the aldehyde dehydrogenase family
K6T24_RS21350	COG1454	alcohol dehydrogenase
K6T24_RS21355	COG0626	cystathionine gamma-synthase activity
K6T24_RS21360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K6T24_RS21385	COG0768	penicillin binding
K6T24_RS21400	COG0826	peptidase U32
K6T24_RS21405	COG0826	peptidase U32
K6T24_RS21410	COG4122	O-methyltransferase activity
K6T24_RS21415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K6T24_RS21430	COG4472	Bacterial protein of unknown function (DUF965)
K6T24_RS21445	COG0628	permease
K6T24_RS21465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K6T24_RS21480	COG1104	cysteine desulfurase activity
K6T24_RS21485	COG1959	2 iron, 2 sulfur cluster binding
K6T24_RS21490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K6T24_RS21500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K6T24_RS21535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K6T24_RS21545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K6T24_RS21545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K6T24_RS21550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K6T24_RS21555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6T24_RS21555	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K6T24_RS21565	COG2244	polysaccharide biosynthetic process
K6T24_RS21570	COG2323	membrane
K6T24_RS21580	COG1862	Preprotein translocase
K6T24_RS21585	COG0343	queuine tRNA-ribosyltransferase activity
K6T24_RS21600	COG2255	four-way junction helicase activity
K6T24_RS21605	COG0632	four-way junction helicase activity
K6T24_RS21610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K6T24_RS21640	COG0157	Belongs to the NadC ModD family
K6T24_RS21645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K6T24_RS21650	COG1104	cysteine desulfurase activity
K6T24_RS21655	COG1827	regulation of RNA biosynthetic process
K6T24_RS21660	COG2258	MOSC domain
K6T24_RS21665	COG0077	Prephenate dehydratase
K6T24_RS21670	COG0577	efflux transmembrane transporter activity
K6T24_RS21675	COG0577	efflux transmembrane transporter activity
K6T24_RS21680	COG1136	(ABC) transporter
K6T24_RS21685	COG5002	protein histidine kinase activity
K6T24_RS21690	COG0745	RESPONSE REGULATOR receiver
K6T24_RS21700	COG3290	protein histidine kinase activity
K6T24_RS21710	COG2868	ribosomal protein
K6T24_RS21720	COG1530	ribonuclease E activity
K6T24_RS21725	COG1994	Peptidase M50
K6T24_RS21730	COG0739	heme binding
K6T24_RS21735	COG2894	cell division
K6T24_RS21755	COG1077	Cell shape determining protein MreB Mrl
K6T24_RS21775	COG0285	dihydrofolate synthase activity
K6T24_RS21790	COG1388	LysM domain
K6T24_RS21800	COG0113	porphobilinogen synthase activity
K6T24_RS21805	COG1587	Uroporphyrinogen-III synthase
K6T24_RS21815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K6T24_RS21825	COG1846	Transcriptional regulator
K6T24_RS21830	COG1764	response to oxidative stress
K6T24_RS21845	COG0470	DNA polymerase III
K6T24_RS21845	COG1067	ATP-dependent peptidase activity
K6T24_RS21885	COG0622	Phosphoesterase
K6T24_RS21900	COG5401	PFAM Sporulation and spore germination
K6T24_RS21920	COG1309	transcriptional regulator
K6T24_RS21930	COG2197	response regulator
K6T24_RS21935	COG2233	PERMEase
K6T24_RS21940	COG0402	S-adenosylhomocysteine deaminase activity
K6T24_RS21945	COG1983	PspC domain protein
K6T24_RS21950	COG1396	sequence-specific DNA binding
K6T24_RS21955	COG0697	spore germination
K6T24_RS21965	COG1959	2 iron, 2 sulfur cluster binding
K6T24_RS21970	COG1668	transmembrane transport
K6T24_RS21975	COG4152	abc transporter atp-binding protein
K6T24_RS21980	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K6T24_RS21985	COG1360	Flagellar Motor Protein
K6T24_RS21990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K6T24_RS21995	COG1876	peptidase activity
K6T24_RS22000	COG0824	Thioesterase
K6T24_RS22005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K6T24_RS22010	COG1053	succinate dehydrogenase
K6T24_RS22015	COG2009	succinate dehydrogenase
K6T24_RS22020	COG1719	4-vinyl reductase, 4VR
K6T24_RS22025	COG0322	excinuclease ABC activity
K6T24_RS22030	COG3118	belongs to the thioredoxin family
K6T24_RS22035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K6T24_RS22040	COG2086	electron transfer activity
K6T24_RS22045	COG1024	Enoyl-CoA hydratase
K6T24_RS22050	COG1309	transcriptional regulator
K6T24_RS22055	COG0318	PFAM AMP-dependent synthetase and ligase
K6T24_RS22085	COG2318	DinB family
K6T24_RS22110	COG1131	(ABC) transporter
K6T24_RS22115	COG2205	protein histidine kinase activity
K6T24_RS22120	COG0745	RESPONSE REGULATOR receiver
K6T24_RS22130	COG4895	conserved protein (DUF2196)
K6T24_RS22135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K6T24_RS22145	COG4509	Sortase family
K6T24_RS22150	COG1120	ATPase activity
K6T24_RS22165	COG5386	Cell surface protein
K6T24_RS22175	COG5386	Cell surface protein
K6T24_RS22180	COG1114	Component of the transport system for branched-chain amino acids
K6T24_RS22185	COG1187	pseudouridine synthase activity
K6T24_RS22195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K6T24_RS22195	COG1796	DNA polymerase
K6T24_RS22200	COG1286	toxin biosynthetic process
K6T24_RS22205	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K6T24_RS22240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K6T24_RS22250	COG1418	mRNA catabolic process
K6T24_RS22270	COG2814	Major facilitator Superfamily
K6T24_RS22275	COG1566	PFAM secretion protein HlyD family protein
K6T24_RS22280	COG1309	transcriptional regulator
K6T24_RS22285	COG1363	Peptidase, m42
K6T24_RS22310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K6T24_RS22320	COG1484	DNA-dependent DNA replication
K6T24_RS22325	COG3611	Membrane attachment protein
K6T24_RS22335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K6T24_RS22340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6T24_RS22345	COG0237	dephospho-CoA kinase activity
K6T24_RS22350	COG1971	Probably functions as a manganese efflux pump
K6T24_RS22360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6T24_RS22360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K6T24_RS22365	COG5002	protein histidine kinase activity
K6T24_RS22370	COG0745	RESPONSE REGULATOR receiver
K6T24_RS22390	COG0538	isocitrate dehydrogenase activity
K6T24_RS22395	COG0372	Belongs to the citrate synthase family
K6T24_RS22405	COG0628	permease
K6T24_RS22410	COG3030	protein affecting phage T7 exclusion by the F plasmid
K6T24_RS22435	COG1725	Transcriptional regulator
K6T24_RS22440	COG0281	malic enzyme
K6T24_RS22445	COG0587	DNA-directed DNA polymerase activity
K6T24_RS22460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K6T24_RS22475	COG4109	DRTGG domain
K6T24_RS22490	COG0006	proline dipeptidase activity
K6T24_RS22530	COG0662	Cupin 2, conserved barrel domain protein
K6T24_RS22545	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS22550	COG0589	response to stress
K6T24_RS22555	COG0346	lactoylglutathione lyase activity
K6T24_RS22595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS22620	COG0827	DNA restriction-modification system
K6T24_RS22625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K6T24_RS22630	COG3874	Sporulation protein YtfJ
K6T24_RS22645	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K6T24_RS22655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6T24_RS22670	COG1104	cysteine desulfurase activity
K6T24_RS22675	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K6T24_RS22680	COG0583	DNA-binding transcription factor activity
K6T24_RS22685	COG0697	spore germination
K6T24_RS22690	COG1309	transcriptional regulator
K6T24_RS22695	COG1956	GAF domain-containing protein
K6T24_RS22700	COG0626	cystathionine gamma-synthase activity
K6T24_RS22735	COG1595	DNA-templated transcription, initiation
K6T24_RS22745	COG0110	maltose O-acetyltransferase activity
K6T24_RS22750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K6T24_RS22755	COG0454	-acetyltransferase
K6T24_RS22760	COG0517	IMP dehydrogenase activity
K6T24_RS22765	COG0123	including yeast histone deacetylase and acetoin utilization protein
K6T24_RS22780	COG0745	RESPONSE REGULATOR receiver
K6T24_RS22785	COG5002	protein histidine kinase activity
K6T24_RS22790	COG0666	response to abiotic stimulus
K6T24_RS22820	COG1609	Transcriptional regulator
K6T24_RS22830	COG4851	CamS sex pheromone cAM373 precursor
K6T24_RS22835	COG3118	belongs to the thioredoxin family
K6T24_RS22845	COG2309	aminopeptidase activity
K6T24_RS22870	COG0789	Transcriptional regulator
K6T24_RS22885	COG1674	ftsk spoiiie
K6T24_RS22890	COG1388	LysM domain
K6T24_RS22890	COG0860	N-Acetylmuramoyl-L-alanine amidase
K6T24_RS22900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6T24_RS22910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6T24_RS22915	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K6T24_RS22920	COG1363	Peptidase, m42
K6T24_RS22930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS22945	COG0510	thiamine kinase activity
K6T24_RS22950	COG1523	belongs to the glycosyl hydrolase 13 family
K6T24_RS22960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K6T24_RS22965	COG1349	DNA-binding transcription factor activity
K6T24_RS22970	COG1187	pseudouridine synthase activity
K6T24_RS22975	COG2244	polysaccharide biosynthetic process
K6T24_RS22980	COG2081	HI0933 family
K6T24_RS22985	COG2814	Major facilitator Superfamily
K6T24_RS22995	COG3832	glyoxalase III activity
K6T24_RS23020	COG1329	Transcriptional regulator
K6T24_RS23045	COG0314	molybdopterin synthase activity
K6T24_RS23050	COG1763	Mo-molybdopterin cofactor biosynthetic process
K6T24_RS23055	COG0303	'Molybdopterin
K6T24_RS23065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K6T24_RS23070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K6T24_RS23090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K6T24_RS23100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K6T24_RS23145	COG2814	Major facilitator Superfamily
K6T24_RS23150	COG0475	glutathione-regulated potassium exporter activity
K6T24_RS23155	COG0490	domain, Protein
K6T24_RS23160	COG0582	viral genome integration into host DNA
K6T24_RS23175	COG1136	(ABC) transporter
K6T24_RS23195	COG1242	4 iron, 4 sulfur cluster binding
K6T24_RS23200	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K6T24_RS23205	COG1794	racemase activity, acting on amino acids and derivatives
K6T24_RS23225	COG2267	carboxylic ester hydrolase activity
K6T24_RS23230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K6T24_RS23235	COG0671	phosphoesterase, PA-phosphatase related
K6T24_RS23240	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS23300	COG3852	Histidine kinase
K6T24_RS23305	COG3852	Histidine kinase
K6T24_RS23315	COG2267	carboxylic ester hydrolase activity
K6T24_RS23320	COG1368	sulfuric ester hydrolase activity
K6T24_RS23335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K6T24_RS23340	COG1116	anion transmembrane transporter activity
K6T24_RS23345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K6T24_RS23370	COG0494	nUDIX hydrolase
K6T24_RS23400	COG2076	Multidrug Resistance protein
K6T24_RS23405	COG2076	Multidrug Resistance protein
K6T24_RS23410	COG0789	Transcriptional regulator
K6T24_RS23415	COG1854	S-ribosylhomocysteine lyase activity
K6T24_RS23425	COG0288	reversible hydration of carbon dioxide
K6T24_RS23430	COG1271	oxidase subunit
K6T24_RS23435	COG1294	oxidase, subunit
K6T24_RS23450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS23475	COG1842	Phage shock protein A
K6T24_RS23500	COG3859	Proton-coupled thiamine transporter YuaJ
K6T24_RS23505	COG5002	protein histidine kinase activity
K6T24_RS23510	COG0745	RESPONSE REGULATOR receiver
K6T24_RS23535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K6T24_RS23540	COG1597	lipid kinase activity
K6T24_RS23550	COG0577	efflux transmembrane transporter activity
K6T24_RS23555	COG1136	(ABC) transporter
K6T24_RS23580	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS23585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K6T24_RS23590	COG0577	efflux transmembrane transporter activity
K6T24_RS23595	COG1136	(ABC) transporter
K6T24_RS23600	COG2207	Transcriptional regulator
K6T24_RS23600	COG3708	Transcriptional regulator
K6T24_RS23610	COG1131	(ABC) transporter
K6T24_RS23615	COG5658	integral membrane protein
K6T24_RS23620	COG0640	Transcriptional regulator
K6T24_RS23630	COG1595	DNA-templated transcription, initiation
K6T24_RS23635	COG0745	RESPONSE REGULATOR receiver
K6T24_RS23640	COG2205	protein histidine kinase activity
K6T24_RS23645	COG0577	efflux transmembrane transporter activity
K6T24_RS23650	COG0577	efflux transmembrane transporter activity
K6T24_RS23655	COG1136	(ABC) transporter
K6T24_RS23660	COG0577	efflux transmembrane transporter activity
K6T24_RS23675	COG2188	Transcriptional regulator
K6T24_RS23695	COG3964	amidohydrolase
K6T24_RS23710	COG0745	RESPONSE REGULATOR receiver
K6T24_RS23715	COG4948	Mandelate Racemase Muconate Lactonizing
K6T24_RS23725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K6T24_RS23730	COG0596	Alpha beta hydrolase
K6T24_RS23740	COG1169	isochorismate synthase
K6T24_RS23745	COG1575	Belongs to the MenA family. Type 1 subfamily
K6T24_RS23750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K6T24_RS23755	COG1278	Cold shock
K6T24_RS23775	COG0058	SHG alpha-glucan phosphorylase activity
K6T24_RS23785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6T24_RS23790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K6T24_RS23805	COG1404	Belongs to the peptidase S8 family
K6T24_RS23950	COG1285	pathogenesis
K6T24_RS23955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6T24_RS23970	COG2155	Conserved Protein
K6T24_RS23975	COG1098	S1 RNA binding domain
K6T24_RS23980	COG0436	Aminotransferase
K6T24_RS23985	COG1522	sequence-specific DNA binding
K6T24_RS23990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K6T24_RS23995	COG2267	carboxylic ester hydrolase activity
K6T24_RS24005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K6T24_RS24025	COG5018	Exonuclease
K6T24_RS24030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6T24_RS24050	COG2050	protein possibly involved in aromatic compounds catabolism
K6T24_RS24060	COG1268	BioY protein
K6T24_RS24065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6T24_RS24070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K6T24_RS24085	COG3584	3D domain protein
K6T24_RS24100	COG1252	NADH dehydrogenase
K6T24_RS24110	COG3708	Transcriptional regulator
K6T24_RS24125	COG1683	Conserved Protein
K6T24_RS24145	COG0316	Belongs to the HesB IscA family
K6T24_RS24160	COG1252	NADH dehydrogenase
K6T24_RS24175	COG0390	transport system, permease component
K6T24_RS24180	COG2824	Alkylphosphonate utilization operon protein PhnA
K6T24_RS24205	COG4837	Protein of unknown function (DUF1462)
K6T24_RS24210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K6T24_RS24220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K6T24_RS24225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K6T24_RS24245	COG2249	NAD(P)H dehydrogenase (quinone) activity
K6T24_RS24255	COG0647	UMP catabolic process
K6T24_RS24265	COG2445	Protein of unknown function DUF86
K6T24_RS24270	COG1494	fructose-1,6-bisphosphatase
K6T24_RS24285	COG4470	Protein conserved in bacteria
K6T24_RS24295	COG0789	Transcriptional regulator
K6T24_RS24300	COG4377	Putative membrane peptidase family (DUF2324)
K6T24_RS24325	COG0739	heme binding
K6T24_RS24335	COG3377	Domain of unknown function (DUF1805)
K6T24_RS24340	COG0737	Belongs to the 5'-nucleotidase family
K6T24_RS24345	COG0719	Fe-S assembly protein
K6T24_RS24350	COG0822	iron-sulfur transferase activity
K6T24_RS24355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K6T24_RS24360	COG0719	Fe-S assembly protein
K6T24_RS24365	COG0396	ATPase activity
K6T24_RS24370	COG1464	Belongs to the NlpA lipoprotein family
K6T24_RS24375	COG1464	Belongs to the NlpA lipoprotein family
K6T24_RS24380	COG2011	ABC-type metal ion transport system permease component
K6T24_RS24395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K6T24_RS24400	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K6T24_RS24410	COG1393	Belongs to the ArsC family
K6T24_RS24430	COG0039	L-malate dehydrogenase activity
K6T24_RS24450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K6T24_RS24455	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS24460	COG0183	Belongs to the thiolase family
K6T24_RS24465	COG1024	Enoyl-CoA hydratase
K6T24_RS24465	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6T24_RS24475	COG1686	Belongs to the peptidase S11 family
K6T24_RS24480	COG0506	proline dehydrogenase activity
K6T24_RS24490	COG0011	TIGRFAM Protein of
K6T24_RS24495	COG0840	transmembrane signaling receptor activity
K6T24_RS24515	COG2814	Major facilitator Superfamily
K6T24_RS24520	COG0531	amino acid
K6T24_RS24540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K6T24_RS24575	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS24585	COG1376	ErfK ybiS ycfS ynhG family protein
K6T24_RS24590	COG0745	RESPONSE REGULATOR receiver
K6T24_RS24595	COG5002	protein histidine kinase activity
K6T24_RS24620	COG0840	transmembrane signaling receptor activity
K6T24_RS24625	COG2151	metal-sulfur cluster biosynthetic enzyme
K6T24_RS24630	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS24650	COG0586	Pfam SNARE associated Golgi protein
K6T24_RS24655	COG0475	glutathione-regulated potassium exporter activity
K6T24_RS24660	COG0490	domain, Protein
K6T24_RS24665	COG1115	amino acid carrier protein
K6T24_RS24670	COG0783	Belongs to the Dps family
K6T24_RS24685	COG1611	Belongs to the LOG family
K6T24_RS24695	COG1528	Iron-storage protein
K6T24_RS24700	COG2311	Membrane
K6T24_RS24705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS24710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS24715	COG1115	amino acid carrier protein
K6T24_RS24720	COG1115	amino acid carrier protein
K6T24_RS24725	COG2910	NAD(P)H-binding
K6T24_RS24740	COG0656	L-ascorbic acid biosynthetic process
K6T24_RS24745	COG2814	Major facilitator Superfamily
K6T24_RS24750	COG1733	regulation of RNA biosynthetic process
K6T24_RS24760	COG1252	NADH dehydrogenase
K6T24_RS24765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K6T24_RS24780	COG0840	transmembrane signaling receptor activity
K6T24_RS24780	COG3290	protein histidine kinase activity
K6T24_RS24790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K6T24_RS24815	COG0488	(ABC) transporter
K6T24_RS24820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS24835	COG1335	isochorismatase
K6T24_RS24840	COG1522	sequence-specific DNA binding
K6T24_RS24875	COG1522	sequence-specific DNA binding
K6T24_RS24880	COG0288	reversible hydration of carbon dioxide
K6T24_RS24885	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
K6T24_RS24890	COG2233	PERMEase
K6T24_RS24940	COG0557	exoribonuclease II activity
K6T24_RS24945	COG1647	Serine aminopeptidase, S33
K6T24_RS24950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K6T24_RS24955	COG1346	cytolysis
K6T24_RS24990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K6T24_RS25005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K6T24_RS25045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K6T24_RS25060	COG2323	membrane
K6T24_RS25070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K6T24_RS25080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K6T24_RS25090	COG1051	belongs to the nudix hydrolase family
K6T24_RS25100	COG0492	ferredoxin-NADP+ reductase activity
K6T24_RS25105	COG0457	Tetratricopeptide repeat
K6T24_RS25110	COG0110	maltose O-acetyltransferase activity
K6T24_RS25130	COG1950	PFAM Membrane protein of
K6T24_RS25140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K6T24_RS25145	COG0556	nucleotide-excision repair
K6T24_RS25160	COG0789	Transcriptional regulator
K6T24_RS25190	COG0583	DNA-binding transcription factor activity
K6T24_RS25195	COG0789	Transcriptional regulator
K6T24_RS25200	COG0655	NAD(P)H dehydrogenase (quinone) activity
K6T24_RS25205	COG0488	(ABC) transporter
K6T24_RS25215	COG1132	(ABC) transporter
K6T24_RS25220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6T24_RS25225	COG0793	Belongs to the peptidase S41A family
K6T24_RS25225	COG3409	Peptidoglycan-binding domain 1 protein
K6T24_RS25230	COG2177	Part of the ABC transporter FtsEX involved in
K6T24_RS25235	COG2884	Cell division ATP-binding protein ftsE
K6T24_RS25255	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K6T24_RS25260	COG1278	Cold shock
K6T24_RS25265	COG1040	competence protein
K6T24_RS25270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K6T24_RS25275	COG0791	NLP P60 protein
K6T24_RS25275	COG1388	LysM domain
K6T24_RS25280	COG1733	regulation of RNA biosynthetic process
K6T24_RS25285	COG1307	EDD domain protein, DegV family
K6T24_RS25290	COG1739	Uncharacterized protein family UPF0029
K6T24_RS25295	COG1316	TRANSCRIPTIONal
K6T24_RS25300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6T24_RS25305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K6T24_RS25310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K6T24_RS25320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K6T24_RS25320	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K6T24_RS25340	COG1486	melibiose metabolic process
K6T24_RS25345	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6T24_RS25350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6T24_RS25370	COG1447	Phosphotransferase system cellobiose-specific component IIA
K6T24_RS25380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K6T24_RS25385	COG1301	dicarboxylic acid transport
K6T24_RS25395	COG0346	lactoylglutathione lyase activity
K6T24_RS25400	COG1511	domain protein
K6T24_RS25405	COG0583	DNA-binding transcription factor activity
K6T24_RS25410	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K6T24_RS25420	COG1271	oxidase subunit
K6T24_RS25425	COG1294	oxidase, subunit
K6T24_RS25430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K6T24_RS25440	COG1620	l-lactate permease
K6T24_RS25450	COG2389	metal-binding protein
K6T24_RS25460	COG1368	sulfuric ester hydrolase activity
K6T24_RS25470	COG1388	LysM domain
K6T24_RS25470	COG0791	NLP P60 protein
K6T24_RS25475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K6T24_RS25485	COG1215	transferase activity, transferring glycosyl groups
K6T24_RS25490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6T24_RS25495	COG1388	LysM domain
K6T24_RS25495	COG3584	3D domain protein
K6T24_RS25505	COG4715	Zinc finger, swim domain protein
K6T24_RS25510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K6T24_RS25550	COG0577	efflux transmembrane transporter activity
K6T24_RS25555	COG1136	(ABC) transporter
K6T24_RS25565	COG2271	Major facilitator Superfamily
K6T24_RS25580	COG3850	Histidine kinase
K6T24_RS25580	COG5002	protein histidine kinase activity
K6T24_RS25585	COG0745	RESPONSE REGULATOR receiver
K6T24_RS25590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6T24_RS25595	COG4750	Nucleotidyl transferase
K6T24_RS25600	COG0697	spore germination
K6T24_RS25610	COG3475	LICD family
K6T24_RS25625	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6T24_RS25635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K6T24_RS25640	COG2089	acid synthase
K6T24_RS25645	COG1083	cytidylyl-transferase
K6T24_RS25650	COG1086	Polysaccharide biosynthesis protein
K6T24_RS25660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K6T24_RS25680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K6T24_RS25685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K6T24_RS25690	COG4464	protein tyrosine phosphatase activity
K6T24_RS25695	COG0489	protein tyrosine kinase activity
K6T24_RS25700	COG3944	biosynthesis protein
K6T24_RS25705	COG0489	protein tyrosine kinase activity
K6T24_RS25720	COG1609	Transcriptional regulator
K6T24_RS25730	COG0739	heme binding
K6T24_RS25745	COG3279	Response regulator of the LytR AlgR family
K6T24_RS25750	COG2385	sporulation resulting in formation of a cellular spore
K6T24_RS25765	COG4836	Membrane
K6T24_RS25770	COG1007	ATP synthesis coupled electron transport
K6T24_RS25775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6T24_RS25780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K6T24_RS25790	COG0839	Belongs to the complex I subunit 6 family
K6T24_RS25810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K6T24_RS25845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K6T24_RS25855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K6T24_RS25875	COG0356	it plays a direct role in the translocation of protons across the membrane
K6T24_RS25910	COG0698	ribose 5-phosphate isomerase
K6T24_RS25920	COG2190	(PTS) system
K6T24_RS25925	COG2259	Doxx family
K6T24_RS25930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6T24_RS25945	COG0009	L-threonylcarbamoyladenylate synthase
K6T24_RS25965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K6T24_RS25980	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K6T24_RS25985	COG1494	fructose-1,6-bisphosphatase
K6T24_RS26005	COG4821	SIS domain
K6T24_RS26010	COG0504	CTP synthase activity
K6T24_RS26025	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS26030	COG1960	acyl-CoA dehydrogenase activity
K6T24_RS26035	COG1250	3-hydroxyacyl-CoA dehydrogenase
K6T24_RS26045	COG0247	lactate metabolic process
K6T24_RS26045	COG2181	nitrate reductase activity
K6T24_RS26050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K6T24_RS26060	COG5001	Diguanylate cyclase
K6T24_RS26060	COG3300	MHYT domain
K6T24_RS26075	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS26080	COG2197	response regulator
K6T24_RS26085	COG4585	Histidine kinase
K6T24_RS26090	COG0842	Transport permease protein
K6T24_RS26095	COG1131	(ABC) transporter
K6T24_RS26100	COG0024	Methionine aminopeptidase
K6T24_RS26105	COG2234	aminopeptidase activity
K6T24_RS26120	COG4506	Protein conserved in bacteria
K6T24_RS26125	COG1619	proteins homologs of microcin C7 resistance protein MccF
K6T24_RS26145	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K6T24_RS26150	COG2814	Major facilitator Superfamily
K6T24_RS26155	COG0789	Transcriptional regulator
K6T24_RS26160	COG0584	glycerophosphoryl diester phosphodiesterase
K6T24_RS26165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K6T24_RS26175	COG1994	Peptidase M50
K6T24_RS26185	COG1078	dGTPase activity
K6T24_RS26190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K6T24_RS26195	COG1120	ATPase activity
K6T24_RS26200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS26205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K6T24_RS26210	COG4844	belongs to the
K6T24_RS26225	COG0280	phosphate acetyltransferase
K6T24_RS26240	COG3773	Cell wall hydrolase
K6T24_RS26250	COG2363	Small membrane protein
K6T24_RS26260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K6T24_RS26265	COG2233	PERMEase
K6T24_RS26270	COG0561	phosphatase activity
K6T24_RS26275	COG2814	Major facilitator Superfamily
K6T24_RS26285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K6T24_RS26290	COG1131	(ABC) transporter
K6T24_RS26295	COG2755	lipolytic protein G-D-S-L family
K6T24_RS26300	COG1609	Transcriptional regulator
K6T24_RS26310	COG0460	homoserine dehydrogenase
K6T24_RS26320	COG2873	o-acetylhomoserine
K6T24_RS26330	COG1011	Hydrolase
K6T24_RS26335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS26345	COG2197	response regulator
K6T24_RS26350	COG4585	Histidine kinase
K6T24_RS26350	COG2203	Gaf domain
K6T24_RS26355	COG0351	phosphomethylpyrimidine kinase
K6T24_RS26360	COG3706	GGDEF domain
K6T24_RS26365	COG2879	small protein
K6T24_RS26370	COG1966	Carbon starvation protein
K6T24_RS26375	COG3279	Response regulator of the LytR AlgR family
K6T24_RS26380	COG0477	Major facilitator Superfamily
K6T24_RS26390	COG0438	transferase activity, transferring glycosyl groups
K6T24_RS26405	COG0840	transmembrane signaling receptor activity
K6T24_RS26415	COG1607	acyl-coa hydrolase
K6T24_RS26425	COG1215	transferase activity, transferring glycosyl groups
K6T24_RS26435	COG1309	transcriptional regulator
K6T24_RS26440	COG0488	(ABC) transporter
K6T24_RS26460	COG0463	Glycosyl transferase, family 2
K6T24_RS26465	COG1309	transcriptional regulator
K6T24_RS26470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K6T24_RS26475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6T24_RS26475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K6T24_RS26485	COG0628	permease
K6T24_RS26495	COG1380	Effector of murein hydrolase LrgA
K6T24_RS26505	COG3275	phosphorelay sensor kinase activity
K6T24_RS26510	COG2814	Major facilitator Superfamily
K6T24_RS26515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K6T24_RS26520	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K6T24_RS26525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K6T24_RS26545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K6T24_RS26550	COG1272	protein, Hemolysin III
K6T24_RS26575	COG1164	Oligoendopeptidase f
K6T24_RS26595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K6T24_RS26600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K6T24_RS26605	COG4853	Protein conserved in bacteria
K6T24_RS26615	COG5002	protein histidine kinase activity
K6T24_RS26620	COG0745	RESPONSE REGULATOR receiver
K6T24_RS26650	COG0305	Participates in initiation and elongation during chromosome replication
K6T24_RS26660	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K6T24_RS26665	COG4241	membrane
K6T24_RS26675	COG0629	single-stranded DNA binding
K6T24_RS26685	COG0012	GTP binding
K6T24_RS26690	COG4481	Protein conserved in bacteria
K6T24_RS26695	COG0668	transmembrane transport
K6T24_RS26705	COG1475	DNA binding
K6T24_RS26710	COG1192	Involved in chromosome partitioning
K6T24_RS26735	COG1847	R3H domain protein
K6T24_RS26740	COG0706	membrane insertase activity
K6T24_RS26750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K6T24_RS26805	COG0697	spore germination
K6T24_RS26810	COG0531	amino acid
K6T24_RS26820	COG2002	toxin-antitoxin pair type II binding
K6T24_RS26825	COG2323	membrane
K6T24_RS26865	COG1988	membrane-bound metal-dependent
K6T24_RS26875	COG0457	Tetratricopeptide repeat
K6T24_RS26920	COG2304	oxidoreductase activity
K6T24_RS26925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K6T24_RS26945	COG0470	DNA polymerase III
K6T24_RS26960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K6T24_RS26990	COG0457	Tetratricopeptide repeat
K6T24_RS27005	COG3718	enzyme involved in inositol metabolism
K6T24_RS27035	COG0673	inositol 2-dehydrogenase activity
K6T24_RS27040	COG2814	Major facilitator Superfamily
K6T24_RS27045	COG1609	Transcriptional regulator
K6T24_RS27075	COG1404	Belongs to the peptidase S8 family
K6T24_RS27090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K6T24_RS27095	COG0741	lytic transglycosylase activity
K6T24_RS27275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K6T24_RS27275	COG0784	Response regulator, receiver
K6T24_RS27285	COG4585	Histidine kinase
K6T24_RS27335	COG0791	NLP P60 protein
K6T24_RS27335	COG0741	lytic transglycosylase activity
K6T24_RS27375	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K6T24_RS27445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K6T24_RS27480	COG3344	reverse transcriptase
K6T24_RS27495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K6T24_RS27545	COG3344	reverse transcriptase
K6T24_RS27645	COG1780	Probably involved in ribonucleotide reductase function
K6T24_RS27720	COG0745	RESPONSE REGULATOR receiver
K6T24_RS27745	COG1846	Transcriptional regulator
K6T24_RS27760	COG1181	Belongs to the D-alanine--D-alanine ligase family
K6T24_RS27765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K6T24_RS27770	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6T24_RS27775	COG1535	isochorismatase
K6T24_RS27775	COG3433	isochorismatase activity
K6T24_RS27815	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS27820	COG1169	isochorismate synthase
K6T24_RS27825	COG1021	2,3-dihydroxybenzoate-AMP ligase
K6T24_RS27840	COG1132	(ABC) transporter
K6T24_RS27845	COG2801	Transposase and inactivated derivatives
K6T24_RS27865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K6T24_RS27890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K6T24_RS27910	COG0372	Belongs to the citrate synthase family
K6T24_RS27965	COG0640	Transcriptional regulator
K6T24_RS27980	COG2814	Major facilitator Superfamily
K6T24_RS27985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K6T24_RS28010	COG1846	Transcriptional regulator
K6T24_RS28015	COG0702	epimerase
K6T24_RS28090	COG0577	efflux transmembrane transporter activity
K6T24_RS28095	COG1136	(ABC) transporter
K6T24_RS28100	COG4974	Belongs to the 'phage' integrase family
K6T24_RS28125	COG1525	nuclease
K6T24_RS28140	COG0577	efflux transmembrane transporter activity
K6T24_RS28145	COG1136	(ABC) transporter
K6T24_RS28170	COG3344	reverse transcriptase
K6T24_RS28190	COG2002	toxin-antitoxin pair type II binding
K6T24_RS28205	COG2824	Alkylphosphonate utilization operon protein PhnA
K6T24_RS28220	COG0659	secondary active sulfate transmembrane transporter activity
K6T24_RS28300	COG1773	rubredoxin
K6T24_RS28305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K6T24_RS28310	COG0426	domain, Protein
K6T24_RS28325	COG0535	radical SAM domain protein
K6T24_RS28330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K6T24_RS28350	COG3227	Zinc metalloprotease (Elastase)
K6T24_RS28360	COG1957	nucleoside hydrolase
K6T24_RS28370	COG2031	fatty acid transporter
K6T24_RS28420	COG1329	Transcriptional regulator
K6T24_RS28455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K6T24_RS28510	COG3711	transcriptional antiterminator
K6T24_RS28515	COG2190	(PTS) system
K6T24_RS28515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K6T24_RS28515	COG1263	PTS System
K6T24_RS28520	COG2723	6-phospho-beta-galactosidase activity
K6T24_RS28535	COG1329	Transcriptional regulator
K6T24_RS28585	COG1999	signal sequence binding
K6T24_RS28590	COG0662	Cupin 2, conserved barrel domain protein
K6T24_RS28600	COG0010	Belongs to the arginase family
K6T24_RS28610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K6T24_RS28625	COG0456	acetyltransferase
K6T24_RS28650	COG3290	protein histidine kinase activity
K6T24_RS28655	COG4565	transcriptional regulatory protein
K6T24_RS28665	COG0753	catalase activity
K6T24_RS28680	COG0745	RESPONSE REGULATOR receiver
K6T24_RS28710	COG1136	(ABC) transporter
K6T24_RS28790	COG2211	Major facilitator Superfamily
K6T24_RS28810	COG0640	Transcriptional regulator
K6T24_RS28815	COG0346	lactoylglutathione lyase activity
K6T24_RS28820	COG0798	PFAM Bile acid sodium symporter
K6T24_RS28850	COG1910	domain protein
K6T24_RS28875	COG1280	lysine exporter protein (LysE YggA)
K6T24_RS28880	COG3403	YqcI/YcgG family
K6T24_RS28895	COG0725	ABC transporter, periplasmic molybdate-binding protein
K6T24_RS28900	COG0561	phosphatase activity
K6T24_RS28905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K6T24_RS28915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K6T24_RS28920	COG1028	Short-chain dehydrogenase reductase Sdr
K6T24_RS28925	COG4974	Belongs to the 'phage' integrase family
K6T24_RS28930	COG0583	DNA-binding transcription factor activity
K6T24_RS28935	COG2814	Major facilitator Superfamily
K6T24_RS28965	COG5002	protein histidine kinase activity
K6T24_RS29015	COG3409	Peptidoglycan-binding domain 1 protein
K6T24_RS29040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K6T24_RS29085	COG1923	regulation of RNA biosynthetic process
K6T24_RS29095	COG2002	toxin-antitoxin pair type II binding
K6T24_RS29170	COG0791	NLP P60 protein
K6T24_RS29170	COG3883	PFAM NLP P60 protein
K6T24_RS29205	COG3344	reverse transcriptase
K6T24_RS29470	COG1923	regulation of RNA biosynthetic process
K6T24_RS29490	COG1923	regulation of RNA biosynthetic process
K6T24_RS29495	COG0640	Transcriptional regulator
K6T24_RS29500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K6T24_RS29560	COG0577	efflux transmembrane transporter activity
K6T24_RS29565	COG1136	(ABC) transporter