locus-tag	class	description
I6G77_RS00005	COG1187	pseudouridine synthase activity
I6G77_RS00015	COG1333	cytochrome c biogenesis protein
I6G77_RS00020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G77_RS00025	COG0745	RESPONSE REGULATOR receiver
I6G77_RS00030	COG5002	protein histidine kinase activity
I6G77_RS00035	COG2096	Adenosyltransferase
I6G77_RS00040	COG4942	peptidase
I6G77_RS00050	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6G77_RS00055	COG1141	Ferredoxin
I6G77_RS00065	COG0514	ATP-dependent DNA helicase (RecQ)
I6G77_RS00070	COG1266	CAAX protease self-immunity
I6G77_RS00080	COG1408	metallophosphoesterase
I6G77_RS00090	COG4862	establishment of competence for transformation
I6G77_RS00095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G77_RS00115	COG0492	ferredoxin-NADP+ reductase activity
I6G77_RS00190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G77_RS00205	COG0142	geranyltranstransferase activity
I6G77_RS00215	COG0142	geranyltranstransferase activity
I6G77_RS00240	COG0457	Tetratricopeptide repeat
I6G77_RS00260	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G77_RS00265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G77_RS00265	COG2010	Cytochrome c
I6G77_RS00270	COG4347	Protein of unknown function (DUF1405)
I6G77_RS00285	COG2738	Putative neutral zinc metallopeptidase
I6G77_RS00295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS00300	COG1694	Mazg nucleotide pyrophosphohydrolase
I6G77_RS00315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G77_RS00320	COG0438	transferase activity, transferring glycosyl groups
I6G77_RS00355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G77_RS00355	COG1199	ATP-dependent helicase activity
I6G77_RS00375	COG3935	DnaD domain protein
I6G77_RS00380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G77_RS00390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G77_RS00390	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G77_RS00445	COG0116	Belongs to the methyltransferase superfamily
I6G77_RS00455	COG1199	ATP-dependent helicase activity
I6G77_RS00460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6G77_RS00470	COG0024	Methionine aminopeptidase
I6G77_RS00480	COG2233	PERMEase
I6G77_RS00485	COG2311	Membrane
I6G77_RS00490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G77_RS00500	COG0456	acetyltransferase
I6G77_RS00535	COG0754	glutathionylspermidine amidase activity
I6G77_RS00550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G77_RS00575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G77_RS00590	COG1215	transferase activity, transferring glycosyl groups
I6G77_RS00595	COG0438	transferase activity, transferring glycosyl groups
I6G77_RS00610	COG0454	-acetyltransferase
I6G77_RS00630	COG0328	RNA-DNA hybrid ribonuclease activity
I6G77_RS00665	COG3403	YqcI/YcgG family
I6G77_RS00670	COG1280	lysine exporter protein (LysE YggA)
I6G77_RS00685	COG3162	membrane
I6G77_RS00690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G77_RS00695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G77_RS00705	COG0475	glutathione-regulated potassium exporter activity
I6G77_RS00710	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G77_RS00715	COG0789	Transcriptional regulator
I6G77_RS00715	COG4978	Transcriptional regulator
I6G77_RS00725	COG2323	membrane
I6G77_RS00730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G77_RS00765	COG2814	Major facilitator Superfamily
I6G77_RS00785	COG1923	regulation of RNA biosynthetic process
I6G77_RS00795	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G77_RS00805	COG2201	protein-glutamate methylesterase activity
I6G77_RS00810	COG2198	Histidine kinase
I6G77_RS00810	COG0643	Histidine kinase
I6G77_RS00815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G77_RS00815	COG1776	CheC inhibitor of MCP methylation
I6G77_RS00830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G77_RS00850	COG1256	bacterial-type flagellum assembly
I6G77_RS00855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G77_RS00875	COG1815	bacterial-type flagellum-dependent cell motility
I6G77_RS00880	COG1558	bacterial-type flagellum-dependent cell motility
I6G77_RS00890	COG1766	The M ring may be actively involved in energy transduction
I6G77_RS00895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G77_RS00905	COG1157	protein secretion by the type III secretion system
I6G77_RS00925	COG1749	Flagellar hook protein flgE
I6G77_RS00940	COG0784	Response regulator, receiver
I6G77_RS00940	COG0835	chemotaxis
I6G77_RS00950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G77_RS00955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G77_RS00960	COG0741	lytic transglycosylase activity
I6G77_RS00970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G77_RS00975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G77_RS00975	COG1776	CheC inhibitor of MCP methylation
I6G77_RS00985	COG1338	Plays a role in the flagellum-specific transport system
I6G77_RS00990	COG1987	bacterial-type flagellum assembly
I6G77_RS01000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G77_RS01005	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G77_RS01010	COG1419	protein localization to endoplasmic reticulum
I6G77_RS01015	COG4786	Flagellar basal body rod
I6G77_RS01020	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G77_RS01065	COG2329	Antibiotic biosynthesis monooxygenase
I6G77_RS01090	COG3764	Sortase (surface protein transpeptidase)
I6G77_RS01095	COG3764	Sortase (surface protein transpeptidase)
I6G77_RS01125	COG0583	DNA-binding transcription factor activity
I6G77_RS01130	COG3842	ATPase activity
I6G77_RS01135	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G77_RS01175	COG1686	Belongs to the peptidase S11 family
I6G77_RS01185	COG0406	alpha-ribazole phosphatase activity
I6G77_RS01205	COG1846	Transcriptional regulator
I6G77_RS01215	COG0367	asparagine synthase
I6G77_RS01245	COG1802	Transcriptional regulator
I6G77_RS01250	COG0697	spore germination
I6G77_RS01255	COG0523	cobalamin synthesis protein
I6G77_RS01260	COG0701	Predicted permease
I6G77_RS01270	COG1216	Glycosyl transferase, family 2
I6G77_RS01270	COG0438	transferase activity, transferring glycosyl groups
I6G77_RS01275	COG1757	Na H antiporter
I6G77_RS01280	COG0789	Transcriptional regulator
I6G77_RS01285	COG4221	oxidoreductase activity
I6G77_RS01330	COG0534	Mate efflux family protein
I6G77_RS01335	COG3340	Belongs to the peptidase S51 family
I6G77_RS01355	COG0785	Cytochrome C biogenesis protein
I6G77_RS01385	COG2733	membrane
I6G77_RS01420	COG1131	(ABC) transporter
I6G77_RS01440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G77_RS01445	COG0528	UMP kinase activity
I6G77_RS01455	COG1027	Aspartate ammonia-lyase
I6G77_RS01460	COG0281	malic enzyme
I6G77_RS01465	COG4191	Histidine kinase
I6G77_RS01470	COG0784	Response regulator, receiver
I6G77_RS01475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G77_RS01520	COG1051	belongs to the nudix hydrolase family
I6G77_RS01535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS01540	COG2814	Major facilitator Superfamily
I6G77_RS01560	COG0477	Major facilitator Superfamily
I6G77_RS01570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G77_RS01580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G77_RS01585	COG4166	transmembrane transport
I6G77_RS01590	COG2223	nitrite transmembrane transporter activity
I6G77_RS01595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G77_RS01610	COG2244	polysaccharide biosynthetic process
I6G77_RS01615	COG0733	neurotransmitter:sodium symporter activity
I6G77_RS01625	COG5566	PFAM Mor transcription activator
I6G77_RS01630	COG2323	membrane
I6G77_RS01650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G77_RS01655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G77_RS01660	COG0028	Belongs to the TPP enzyme family
I6G77_RS01680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G77_RS01705	COG2814	Major facilitator Superfamily
I6G77_RS01710	COG3384	dioxygenase
I6G77_RS01725	COG3279	Response regulator of the LytR AlgR family
I6G77_RS01730	COG0427	acetyl-CoA hydrolase
I6G77_RS01750	COG4166	transmembrane transport
I6G77_RS01755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS01775	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G77_RS01790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G77_RS01795	COG0531	amino acid
I6G77_RS01830	COG1309	transcriptional regulator
I6G77_RS01835	COG2390	Transcriptional regulator
I6G77_RS01845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS01850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6G77_RS01865	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G77_RS01890	COG0006	proline dipeptidase activity
I6G77_RS01895	COG2132	Multicopper oxidase
I6G77_RS01905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G77_RS01910	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS01915	COG1522	sequence-specific DNA binding
I6G77_RS01955	COG0583	DNA-binding transcription factor activity
I6G77_RS01960	COG0367	asparagine synthase
I6G77_RS01980	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS01990	COG2372	response to copper ion
I6G77_RS01990	COG1276	copper resistance
I6G77_RS01995	COG4549	nuclear export factor GLE1
I6G77_RS02000	COG0697	spore germination
I6G77_RS02005	COG0583	DNA-binding transcription factor activity
I6G77_RS02010	COG1959	2 iron, 2 sulfur cluster binding
I6G77_RS02015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G77_RS02020	COG0778	Nitroreductase
I6G77_RS02030	COG0628	permease
I6G77_RS02040	COG1231	oxidoreductase activity
I6G77_RS02045	COG0523	cobalamin synthesis protein
I6G77_RS02055	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS02060	COG2030	dehydratase
I6G77_RS02065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G77_RS02080	COG0411	ABC transporter
I6G77_RS02100	COG0583	DNA-binding transcription factor activity
I6G77_RS02110	COG1942	4-Oxalocrotonate Tautomerase
I6G77_RS02125	COG1271	oxidase subunit
I6G77_RS02130	COG1294	oxidase, subunit
I6G77_RS02135	COG4988	ABC transporter
I6G77_RS02140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G77_RS02150	COG1216	Glycosyl transferase, family 2
I6G77_RS02180	COG1686	Belongs to the peptidase S11 family
I6G77_RS02195	COG0791	NLP P60 protein
I6G77_RS02195	COG1388	LysM domain
I6G77_RS02205	COG1132	(ABC) transporter
I6G77_RS02210	COG0745	RESPONSE REGULATOR receiver
I6G77_RS02215	COG5002	protein histidine kinase activity
I6G77_RS02220	COG2205	protein histidine kinase activity
I6G77_RS02225	COG0745	RESPONSE REGULATOR receiver
I6G77_RS02250	COG0300	oxidoreductase activity
I6G77_RS02255	COG4122	O-methyltransferase activity
I6G77_RS02285	COG0460	homoserine dehydrogenase
I6G77_RS02310	COG1316	TRANSCRIPTIONal
I6G77_RS02320	COG0745	RESPONSE REGULATOR receiver
I6G77_RS02325	COG5002	protein histidine kinase activity
I6G77_RS02340	COG1285	pathogenesis
I6G77_RS02345	COG1247	-acetyltransferase
I6G77_RS02365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G77_RS02375	COG1082	Xylose isomerase domain protein TIM barrel
I6G77_RS02385	COG2814	Major facilitator Superfamily
I6G77_RS02390	COG1279	arginine transmembrane transporter activity
I6G77_RS02395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS02405	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G77_RS02440	COG0577	efflux transmembrane transporter activity
I6G77_RS02445	COG2002	toxin-antitoxin pair type II binding
I6G77_RS02450	COG1404	Belongs to the peptidase S8 family
I6G77_RS02455	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6G77_RS02460	COG0640	Transcriptional regulator
I6G77_RS02465	COG0667	Aldo Keto reductase
I6G77_RS02470	COG2814	Major facilitator Superfamily
I6G77_RS02510	COG3949	Membrane
I6G77_RS02515	COG0783	Belongs to the Dps family
I6G77_RS02530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G77_RS02540	COG1231	oxidoreductase activity
I6G77_RS02545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS02550	COG4989	oxidoreductase activity
I6G77_RS02555	COG0523	cobalamin synthesis protein
I6G77_RS02560	COG0456	acetyltransferase
I6G77_RS02565	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G77_RS02565	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G77_RS02575	COG0702	epimerase
I6G77_RS02585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G77_RS02595	COG4166	transmembrane transport
I6G77_RS02610	COG0406	alpha-ribazole phosphatase activity
I6G77_RS02620	COG5337	Spore coat protein CotH
I6G77_RS02625	COG1051	belongs to the nudix hydrolase family
I6G77_RS02630	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS02635	COG2244	polysaccharide biosynthetic process
I6G77_RS02645	COG0701	Predicted permease
I6G77_RS02650	COG3689	TIGRFAM TIGR03943 family protein
I6G77_RS02655	COG1607	acyl-coa hydrolase
I6G77_RS02665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G77_RS02680	COG0702	epimerase
I6G77_RS02685	COG2839	Protein conserved in bacteria
I6G77_RS02690	COG1253	flavin adenine dinucleotide binding
I6G77_RS02705	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS02710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G77_RS02730	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS02740	COG1876	peptidase activity
I6G77_RS02750	COG0154	amidase activity
I6G77_RS02755	COG2211	Major facilitator Superfamily
I6G77_RS02790	COG0561	phosphatase activity
I6G77_RS02800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G77_RS02805	COG4106	trans-aconitate 2-methyltransferase activity
I6G77_RS02825	COG1819	glycosyl
I6G77_RS02830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS02835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS02865	COG0456	acetyltransferase
I6G77_RS02905	COG3874	Sporulation protein YtfJ
I6G77_RS02930	COG2226	methyltransferase
I6G77_RS02950	COG0346	lactoylglutathione lyase activity
I6G77_RS02960	COG0604	alcohol dehydrogenase
I6G77_RS02965	COG1595	DNA-templated transcription, initiation
I6G77_RS02980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G77_RS03000	COG0386	Belongs to the glutathione peroxidase family
I6G77_RS03005	COG1305	Transglutaminase-like
I6G77_RS03010	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I6G77_RS03015	COG0714	Associated with various cellular activities
I6G77_RS03020	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G77_RS03025	COG1140	nitrate reductase beta subunit
I6G77_RS03030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G77_RS03035	COG2181	nitrate reductase activity
I6G77_RS03055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G77_RS03060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G77_RS03065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G77_RS03070	COG0303	'Molybdopterin
I6G77_RS03075	COG0314	molybdopterin synthase activity
I6G77_RS03085	COG2223	nitrite transmembrane transporter activity
I6G77_RS03105	COG1648	precorrin-2 dehydrogenase activity
I6G77_RS03115	COG1587	Uroporphyrinogen-III synthase
I6G77_RS03115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G77_RS03120	COG2146	nitrite reductase [NAD(P)H] activity
I6G77_RS03125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G77_RS03130	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G77_RS03160	COG2359	stage V sporulation protein S
I6G77_RS03170	COG1418	mRNA catabolic process
I6G77_RS03175	COG0488	(ABC) transporter
I6G77_RS03190	COG0629	single-stranded DNA binding
I6G77_RS03195	COG1413	lyase activity
I6G77_RS03210	COG2136	Putative SAM-dependent methyltransferase
I6G77_RS03210	COG2521	methyltransferase
I6G77_RS03215	COG0018	arginyl-trna synthetase
I6G77_RS03250	COG0017	Asparaginyl-tRNA synthetase
I6G77_RS03255	COG1929	Belongs to the glycerate kinase type-1 family
I6G77_RS03265	COG0733	neurotransmitter:sodium symporter activity
I6G77_RS03290	COG2610	gluconate transmembrane transporter activity
I6G77_RS03295	COG1454	alcohol dehydrogenase
I6G77_RS03300	COG1794	racemase activity, acting on amino acids and derivatives
I6G77_RS03310	COG0456	acetyltransferase
I6G77_RS03315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G77_RS03325	COG1131	(ABC) transporter
I6G77_RS03330	COG4473	ABC transporter
I6G77_RS03340	COG0546	phosphoglycolate phosphatase activity
I6G77_RS03355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G77_RS03370	COG0768	penicillin binding
I6G77_RS03380	COG0204	Acyl-transferase
I6G77_RS03385	COG1272	protein, Hemolysin III
I6G77_RS03395	COG0805	protein transport
I6G77_RS03405	COG1307	EDD domain protein, DegV family
I6G77_RS03410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G77_RS03415	COG1999	signal sequence binding
I6G77_RS03420	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G77_RS03425	COG0367	asparagine synthase
I6G77_RS03445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS03450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G77_RS03465	COG1335	isochorismatase
I6G77_RS03470	COG1051	belongs to the nudix hydrolase family
I6G77_RS03480	COG0668	transmembrane transport
I6G77_RS03485	COG4585	Histidine kinase
I6G77_RS03485	COG2203	Gaf domain
I6G77_RS03490	COG2197	response regulator
I6G77_RS03495	COG1737	Transcriptional regulator
I6G77_RS03500	COG1064	alcohol dehydrogenase
I6G77_RS03525	COG1070	Carbohydrate kinase
I6G77_RS03535	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6G77_RS03570	COG0517	IMP dehydrogenase activity
I6G77_RS03570	COG1125	glycine betaine transport
I6G77_RS03575	COG1174	glycine betaine transport
I6G77_RS03610	COG1253	flavin adenine dinucleotide binding
I6G77_RS03615	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS03620	COG5506	Protein of unknown function (DUF1694)
I6G77_RS03635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G77_RS03640	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G77_RS03645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G77_RS03650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G77_RS03655	COG0456	acetyltransferase
I6G77_RS03660	COG3829	transcription factor binding
I6G77_RS03665	COG1509	lysine 2,3-aminomutase activity
I6G77_RS03700	COG4991	sh3 domain protein
I6G77_RS03700	COG0515	serine threonine protein kinase
I6G77_RS03700	COG3064	Membrane
I6G77_RS03705	COG4326	sporulation control protein
I6G77_RS03710	COG0671	phosphoesterase, PA-phosphatase related
I6G77_RS03715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G77_RS03720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G77_RS03775	COG1595	DNA-templated transcription, initiation
I6G77_RS03810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G77_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS03860	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6G77_RS03860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G77_RS03870	COG2814	Major facilitator Superfamily
I6G77_RS03875	COG4841	protein insertion into membrane
I6G77_RS03880	COG0372	Belongs to the citrate synthase family
I6G77_RS03885	COG2079	MmgE PrpD family protein
I6G77_RS03890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G77_RS03895	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS03900	COG2084	Dehydrogenase
I6G77_RS03910	COG1280	lysine exporter protein (LysE YggA)
I6G77_RS03915	COG1024	Enoyl-CoA hydratase
I6G77_RS03930	COG0420	3'-5' exonuclease activity
I6G77_RS03955	COG2223	nitrite transmembrane transporter activity
I6G77_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS03965	COG1169	isochorismate synthase
I6G77_RS03970	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G77_RS03975	COG1535	isochorismatase
I6G77_RS03975	COG3433	isochorismatase activity
I6G77_RS03980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G77_RS03990	COG2814	Major facilitator Superfamily
I6G77_RS04005	COG0776	regulation of translation
I6G77_RS04015	COG2318	DinB family
I6G77_RS04025	COG1115	amino acid carrier protein
I6G77_RS04040	COG2329	Antibiotic biosynthesis monooxygenase
I6G77_RS04045	COG1187	pseudouridine synthase activity
I6G77_RS04050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G77_RS04055	COG1136	(ABC) transporter
I6G77_RS04065	COG2814	Major facilitator Superfamily
I6G77_RS04080	COG0028	Belongs to the TPP enzyme family
I6G77_RS04090	COG2226	methyltransferase
I6G77_RS04130	COG1846	Transcriptional regulator
I6G77_RS04165	COG1247	-acetyltransferase
I6G77_RS04190	COG0596	Alpha beta hydrolase
I6G77_RS04195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G77_RS04205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS04215	COG1278	Cold shock
I6G77_RS04340	COG0592	DNA-directed DNA polymerase activity
I6G77_RS04345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G77_RS04345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G77_RS04430	COG2002	toxin-antitoxin pair type II binding
I6G77_RS04450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G77_RS04450	COG0515	serine threonine protein kinase
I6G77_RS04650	COG0010	Belongs to the arginase family
I6G77_RS04655	COG0561	phosphatase activity
I6G77_RS04665	COG0583	DNA-binding transcription factor activity
I6G77_RS04670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G77_RS04685	COG0583	DNA-binding transcription factor activity
I6G77_RS04690	COG2258	MOSC domain
I6G77_RS04705	COG1132	(ABC) transporter
I6G77_RS04710	COG1132	(ABC) transporter
I6G77_RS04730	COG1396	sequence-specific DNA binding
I6G77_RS04760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G77_RS04770	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6G77_RS04775	COG1595	DNA-templated transcription, initiation
I6G77_RS04800	COG1649	PFAM Uncharacterised BCR, COG1649
I6G77_RS04825	COG2971	BadF BadG BcrA BcrD
I6G77_RS04845	COG1846	Transcriptional regulator
I6G77_RS04870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS04910	COG1309	transcriptional regulator
I6G77_RS04925	COG1136	(ABC) transporter
I6G77_RS04930	COG3615	Tellurite resistance protein tehB
I6G77_RS04930	COG0500	methyltransferase
I6G77_RS04940	COG2226	methyltransferase
I6G77_RS04945	COG3961	Belongs to the TPP enzyme family
I6G77_RS04950	COG1846	Transcriptional regulator
I6G77_RS04975	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G77_RS04985	COG0110	maltose O-acetyltransferase activity
I6G77_RS05005	COG1760	l-serine dehydratase
I6G77_RS05010	COG1760	l-serine dehydratase
I6G77_RS05015	COG0814	amino acid
I6G77_RS05035	COG1533	DNA photolyase activity
I6G77_RS05040	COG0076	glutamate decarboxylase activity
I6G77_RS05070	COG0768	penicillin binding
I6G77_RS05075	COG1595	DNA-templated transcription, initiation
I6G77_RS05085	COG0768	penicillin binding
I6G77_RS05090	COG0768	penicillin binding
I6G77_RS05095	COG2367	Beta-lactamase
I6G77_RS05100	COG1408	metallophosphoesterase
I6G77_RS05110	COG1131	(ABC) transporter
I6G77_RS05120	COG1309	transcriptional regulator
I6G77_RS05135	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS05140	COG0439	Biotin carboxylase
I6G77_RS05145	COG0511	ligase activity, forming carbon-carbon bonds
I6G77_RS05150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G77_RS05155	COG1024	Enoyl-CoA hydratase
I6G77_RS05160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G77_RS05165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G77_RS05185	COG0572	uridine kinase
I6G77_RS05195	COG2318	DinB family
I6G77_RS05200	COG1686	Belongs to the peptidase S11 family
I6G77_RS05230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G77_RS05250	COG3227	Zinc metalloprotease (Elastase)
I6G77_RS05265	COG2814	Major facilitator Superfamily
I6G77_RS05275	COG1733	regulation of RNA biosynthetic process
I6G77_RS05280	COG2226	methyltransferase
I6G77_RS05295	COG1131	(ABC) transporter
I6G77_RS05305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G77_RS05325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS05335	COG2368	4-hydroxyphenylacetate
I6G77_RS05355	COG2323	membrane
I6G77_RS05365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G77_RS05375	COG3386	PFAM SMP-30 Gluconolaconase
I6G77_RS05385	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I6G77_RS05390	COG3773	Cell wall hydrolase
I6G77_RS05400	COG0745	RESPONSE REGULATOR receiver
I6G77_RS05405	COG2205	protein histidine kinase activity
I6G77_RS05415	COG0488	(ABC) transporter
I6G77_RS05430	COG1136	(ABC) transporter
I6G77_RS05435	COG0577	efflux transmembrane transporter activity
I6G77_RS05455	COG0460	homoserine dehydrogenase
I6G77_RS05460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS05470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G77_RS05505	COG1191	sigma factor activity
I6G77_RS05575	COG2124	cytochrome p450
I6G77_RS05610	COG0561	phosphatase activity
I6G77_RS05615	COG5002	protein histidine kinase activity
I6G77_RS05620	COG1819	glycosyl
I6G77_RS05625	COG1794	racemase activity, acting on amino acids and derivatives
I6G77_RS05650	COG2205	protein histidine kinase activity
I6G77_RS05660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G77_RS05675	COG5002	protein histidine kinase activity
I6G77_RS05680	COG0604	alcohol dehydrogenase
I6G77_RS05685	COG0671	phosphoesterase, PA-phosphatase related
I6G77_RS05690	COG0768	penicillin binding
I6G77_RS05730	COG0693	protein deglycase activity
I6G77_RS05740	COG2814	Major facilitator Superfamily
I6G77_RS05750	COG2814	Major facilitator Superfamily
I6G77_RS05765	COG0584	glycerophosphoryl diester phosphodiesterase
I6G77_RS05780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS05785	COG0697	spore germination
I6G77_RS05805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G77_RS05820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G77_RS05830	COG2223	nitrite transmembrane transporter activity
I6G77_RS05845	COG2816	NAD+ diphosphatase activity
I6G77_RS05850	COG0592	DNA-directed DNA polymerase activity
I6G77_RS05875	COG3878	Protein conserved in bacteria
I6G77_RS05895	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G77_RS05935	COG0322	excinuclease ABC activity
I6G77_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G77_RS06000	COG1011	Hydrolase
I6G77_RS06020	COG1523	belongs to the glycosyl hydrolase 13 family
I6G77_RS06025	COG3227	Zinc metalloprotease (Elastase)
I6G77_RS06040	COG0201	protein transport
I6G77_RS06050	COG0697	spore germination
I6G77_RS06055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS06100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS06115	COG2959	enzyme of heme biosynthesis
I6G77_RS06155	COG1309	transcriptional regulator
I6G77_RS06175	COG3284	Transcriptional regulator
I6G77_RS06195	COG1349	DNA-binding transcription factor activity
I6G77_RS06215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G77_RS06220	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G77_RS06225	COG0022	dehydrogenase e1 component
I6G77_RS06230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G77_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS06245	COG0456	acetyltransferase
I6G77_RS06245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G77_RS06285	COG4176	ABC-type proline glycine betaine transport system permease component
I6G77_RS06290	COG4175	Glycine betaine
I6G77_RS06290	COG0517	IMP dehydrogenase activity
I6G77_RS06320	COG2153	protein acetylation
I6G77_RS06325	COG3397	chitin binding
I6G77_RS06330	COG1819	glycosyl
I6G77_RS06345	COG2205	protein histidine kinase activity
I6G77_RS06350	COG2226	methyltransferase
I6G77_RS06355	COG2315	Protein conserved in bacteria
I6G77_RS06365	COG0658	competence protein
I6G77_RS06365	COG2333	competence protein COMEC
I6G77_RS06415	COG3973	AAA domain
I6G77_RS06435	COG0514	ATP-dependent DNA helicase (RecQ)
I6G77_RS06470	COG4637	Psort location Cytoplasmic, score
I6G77_RS06495	COG3397	chitin binding
I6G77_RS06510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G77_RS06515	COG1115	amino acid carrier protein
I6G77_RS06520	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS06525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G77_RS06535	COG3938	Belongs to the proline racemase family
I6G77_RS06540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G77_RS06580	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS06595	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G77_RS06610	COG4166	transmembrane transport
I6G77_RS06620	COG4948	Mandelate Racemase Muconate Lactonizing
I6G77_RS06665	COG2936	dipeptidyl-peptidase activity
I6G77_RS06670	COG5002	protein histidine kinase activity
I6G77_RS06675	COG0745	RESPONSE REGULATOR receiver
I6G77_RS06705	COG1164	Oligoendopeptidase f
I6G77_RS06710	COG0531	amino acid
I6G77_RS06715	COG1522	sequence-specific DNA binding
I6G77_RS06720	COG1307	EDD domain protein, DegV family
I6G77_RS06770	COG2814	Major facilitator Superfamily
I6G77_RS06780	COG1664	Polymer-forming cytoskeletal
I6G77_RS06785	COG0789	Transcriptional regulator
I6G77_RS06790	COG4533	DNA binding
I6G77_RS06795	COG0477	Major facilitator Superfamily
I6G77_RS06795	COG2814	Major facilitator Superfamily
I6G77_RS06820	COG2261	transglycosylase associated protein
I6G77_RS06835	COG2226	methyltransferase
I6G77_RS06875	COG0436	Aminotransferase
I6G77_RS06880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G77_RS06890	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G77_RS06905	COG1131	(ABC) transporter
I6G77_RS06955	COG0628	permease
I6G77_RS06965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G77_RS06970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G77_RS06975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G77_RS06990	COG2816	NAD+ diphosphatase activity
I6G77_RS07010	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6G77_RS07030	COG0697	spore germination
I6G77_RS07035	COG2318	DinB family
I6G77_RS07040	COG0454	-acetyltransferase
I6G77_RS07065	COG0346	lactoylglutathione lyase activity
I6G77_RS07095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS07100	COG0861	Integral membrane protein TerC family
I6G77_RS07105	COG1368	sulfuric ester hydrolase activity
I6G77_RS07110	COG0488	(ABC) transporter
I6G77_RS07155	COG1033	growth of symbiont in host cell
I6G77_RS07155	COG2409	Drug exporters of the RND superfamily
I6G77_RS07160	COG1309	transcriptional regulator
I6G77_RS07175	COG0287	Prephenate dehydrogenase
I6G77_RS07190	COG1605	Chorismate mutase
I6G77_RS07190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6G77_RS07230	COG3584	3D domain protein
I6G77_RS07230	COG1388	LysM domain
I6G77_RS07250	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G77_RS07265	COG2390	Transcriptional regulator
I6G77_RS07270	COG1070	Carbohydrate kinase
I6G77_RS07285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS07305	COG2329	Antibiotic biosynthesis monooxygenase
I6G77_RS07325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS07340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G77_RS07345	COG4187	Peptidase family M20/M25/M40
I6G77_RS07350	COG1414	Transcriptional regulator
I6G77_RS07355	COG0833	amino acid
I6G77_RS07360	COG1690	Belongs to the RtcB family
I6G77_RS07365	COG3239	Fatty acid desaturase
I6G77_RS07375	COG1785	Belongs to the alkaline phosphatase family
I6G77_RS07385	COG3655	Transcriptional regulator
I6G77_RS07400	COG4377	Putative membrane peptidase family (DUF2324)
I6G77_RS07410	COG3279	Response regulator of the LytR AlgR family
I6G77_RS07425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS07430	COG0346	lactoylglutathione lyase activity
I6G77_RS07450	COG0714	Associated with various cellular activities
I6G77_RS07470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G77_RS07475	COG0753	catalase activity
I6G77_RS07485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G77_RS07510	COG0714	Associated with various cellular activities
I6G77_RS07515	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G77_RS07520	COG0659	secondary active sulfate transmembrane transporter activity
I6G77_RS07540	COG0778	Nitroreductase
I6G77_RS07545	COG1846	Transcriptional regulator
I6G77_RS07565	COG4884	unkown
I6G77_RS07565	COG3831	ATPase activity
I6G77_RS07590	COG0456	acetyltransferase
I6G77_RS07605	COG0697	spore germination
I6G77_RS07610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS07625	COG0642	Histidine kinase
I6G77_RS07630	COG0745	RESPONSE REGULATOR receiver
I6G77_RS07635	COG0596	Alpha beta hydrolase
I6G77_RS07665	COG0730	response to heat
I6G77_RS07675	COG0833	amino acid
I6G77_RS07685	COG4335	DNA alkylation repair
I6G77_RS07690	COG4978	Transcriptional regulator
I6G77_RS07690	COG0789	Transcriptional regulator
I6G77_RS07720	COG0768	penicillin binding
I6G77_RS07730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G77_RS07760	COG1984	allophanate hydrolase subunit 2
I6G77_RS07765	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G77_RS07770	COG1414	Transcriptional regulator
I6G77_RS07780	COG3142	Participates in the control of copper homeostasis
I6G77_RS07785	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS07790	COG0640	Transcriptional regulator
I6G77_RS07805	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS07820	COG3314	Sporulation integral membrane protein YlbJ
I6G77_RS07840	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I6G77_RS07855	COG3848	Pyruvate phosphate dikinase
I6G77_RS07855	COG0574	Belongs to the PEP-utilizing enzyme family
I6G77_RS07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS07885	COG1063	alcohol dehydrogenase
I6G77_RS07895	COG1027	Aspartate ammonia-lyase
I6G77_RS07900	COG0252	asparaginase activity
I6G77_RS07905	COG1396	sequence-specific DNA binding
I6G77_RS07940	COG5002	protein histidine kinase activity
I6G77_RS07965	COG2207	Transcriptional regulator
I6G77_RS07980	COG0322	excinuclease ABC activity
I6G77_RS07985	COG0531	amino acid
I6G77_RS07990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G77_RS08000	COG0531	amino acid
I6G77_RS08005	COG0697	spore germination
I6G77_RS08010	COG0784	Response regulator, receiver
I6G77_RS08015	COG4191	Histidine kinase
I6G77_RS08020	COG2066	Belongs to the glutaminase family
I6G77_RS08025	COG1115	amino acid carrier protein
I6G77_RS08060	COG0737	Belongs to the 5'-nucleotidase family
I6G77_RS08065	COG2267	carboxylic ester hydrolase activity
I6G77_RS08070	COG1335	isochorismatase
I6G77_RS08090	COG0583	DNA-binding transcription factor activity
I6G77_RS08100	COG0598	Magnesium transport protein CorA
I6G77_RS08150	COG0415	Belongs to the DNA photolyase family
I6G77_RS08160	COG2814	Major facilitator Superfamily
I6G77_RS08170	COG0657	acetylesterase activity
I6G77_RS08175	COG0288	reversible hydration of carbon dioxide
I6G77_RS08185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G77_RS08190	COG5609	conserved protein (DUF2294)
I6G77_RS08195	COG2814	Major facilitator Superfamily
I6G77_RS08200	COG0583	DNA-binding transcription factor activity
I6G77_RS08220	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G77_RS08240	COG2211	Major facilitator Superfamily
I6G77_RS08260	COG2267	carboxylic ester hydrolase activity
I6G77_RS08265	COG4641	Protein conserved in bacteria
I6G77_RS08270	COG1136	(ABC) transporter
I6G77_RS08275	COG0577	efflux transmembrane transporter activity
I6G77_RS08280	COG4585	Histidine kinase
I6G77_RS08310	COG0798	PFAM Bile acid sodium symporter
I6G77_RS08315	COG0346	lactoylglutathione lyase activity
I6G77_RS08320	COG0640	Transcriptional regulator
I6G77_RS08345	COG1309	transcriptional regulator
I6G77_RS08350	COG2814	Major facilitator Superfamily
I6G77_RS08355	COG1309	transcriptional regulator
I6G77_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS08365	COG1522	sequence-specific DNA binding
I6G77_RS08385	COG0346	lactoylglutathione lyase activity
I6G77_RS08410	COG2226	methyltransferase
I6G77_RS08415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS08425	COG2814	Major facilitator Superfamily
I6G77_RS08455	COG0745	RESPONSE REGULATOR receiver
I6G77_RS08460	COG3850	Histidine kinase
I6G77_RS08460	COG5002	protein histidine kinase activity
I6G77_RS08485	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G77_RS08505	COG1476	TRANSCRIPTIONal
I6G77_RS08525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6G77_RS08545	COG0577	efflux transmembrane transporter activity
I6G77_RS08560	COG3850	Histidine kinase
I6G77_RS08560	COG5002	protein histidine kinase activity
I6G77_RS08570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS08585	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G77_RS08605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G77_RS08655	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS08655	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS08685	COG1876	peptidase activity
I6G77_RS08690	COG2843	Capsule synthesis protein
I6G77_RS08700	COG0477	Major facilitator Superfamily
I6G77_RS08715	COG1846	Transcriptional regulator
I6G77_RS08720	COG2814	Major facilitator Superfamily
I6G77_RS08730	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G77_RS08735	COG1131	(ABC) transporter
I6G77_RS08755	COG2076	Multidrug Resistance protein
I6G77_RS08760	COG1309	transcriptional regulator
I6G77_RS08770	COG2031	fatty acid transporter
I6G77_RS08780	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G77_RS08815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G77_RS08830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G77_RS08835	COG1288	antiporter activity
I6G77_RS08840	COG2356	endonuclease I
I6G77_RS08850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G77_RS08855	COG2814	Major facilitator Superfamily
I6G77_RS08860	COG1309	transcriptional regulator
I6G77_RS08870	COG0789	Transcriptional regulator
I6G77_RS08900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G77_RS08920	COG1733	regulation of RNA biosynthetic process
I6G77_RS08925	COG0778	Nitroreductase
I6G77_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS08965	COG1131	(ABC) transporter
I6G77_RS08990	COG1011	Hydrolase
I6G77_RS09000	COG2365	Tyrosine phosphatase family
I6G77_RS09020	COG0346	lactoylglutathione lyase activity
I6G77_RS09025	COG1940	carbohydrate kinase activity
I6G77_RS09035	COG0110	maltose O-acetyltransferase activity
I6G77_RS09045	COG1136	(ABC) transporter
I6G77_RS09045	COG0577	efflux transmembrane transporter activity
I6G77_RS09065	COG0628	permease
I6G77_RS09095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G77_RS09105	COG0477	Major facilitator Superfamily
I6G77_RS09135	COG1253	flavin adenine dinucleotide binding
I6G77_RS09140	COG0789	Transcriptional regulator
I6G77_RS09150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G77_RS09175	COG0697	spore germination
I6G77_RS09180	COG1357	PFAM Pentapeptide repeats (8 copies)
I6G77_RS09185	COG3813	Protein conserved in bacteria
I6G77_RS09190	COG2706	6-phosphogluconolactonase activity
I6G77_RS09195	COG1070	Carbohydrate kinase
I6G77_RS09205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G77_RS09210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6G77_RS09220	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G77_RS09255	COG0814	amino acid
I6G77_RS09275	COG1393	Belongs to the ArsC family
I6G77_RS09280	COG2188	Transcriptional regulator
I6G77_RS09285	COG0673	inositol 2-dehydrogenase activity
I6G77_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS09320	COG0384	phenazine biosynthesis protein PhzF
I6G77_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS09345	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS09350	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G77_RS09355	COG1733	regulation of RNA biosynthetic process
I6G77_RS09385	COG1191	sigma factor activity
I6G77_RS09395	COG1280	lysine exporter protein (LysE YggA)
I6G77_RS09415	COG3152	Membrane
I6G77_RS09440	COG1151	hydroxylamine reductase activity
I6G77_RS09485	COG2072	flavoprotein involved in K transport
I6G77_RS09535	COG1695	Transcriptional regulator
I6G77_RS09545	COG1113	amino acid transport
I6G77_RS09550	COG2814	Major facilitator Superfamily
I6G77_RS09570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G77_RS09575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G77_RS09590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS09595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS09600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS09640	COG0583	DNA-binding transcription factor activity
I6G77_RS09660	COG1193	negative regulation of DNA recombination
I6G77_RS09675	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6G77_RS09680	COG1164	Oligoendopeptidase f
I6G77_RS09710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G77_RS09740	COG0584	glycerophosphoryl diester phosphodiesterase
I6G77_RS09750	COG0640	Transcriptional regulator
I6G77_RS09755	COG0604	alcohol dehydrogenase
I6G77_RS09765	COG0457	Tetratricopeptide repeat
I6G77_RS09770	COG2808	Putative FMN-binding domain
I6G77_RS09775	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G77_RS09785	COG0385	Bile acid
I6G77_RS09790	COG0277	FAD linked oxidase domain protein
I6G77_RS09800	COG0825	malonyl-CoA metabolic process
I6G77_RS09815	COG1309	transcriptional regulator
I6G77_RS09845	COG3852	Histidine kinase
I6G77_RS09860	COG1285	pathogenesis
I6G77_RS09880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G77_RS09890	COG2514	catechol 2,3-dioxygenase activity
I6G77_RS09895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS09900	COG1126	abc transporter atp-binding protein
I6G77_RS09905	COG0765	amino acid transport
I6G77_RS09910	COG2720	vancomycin resistance protein
I6G77_RS09950	COG0716	FMN binding
I6G77_RS09960	COG0494	nUDIX hydrolase
I6G77_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS09995	COG0165	Argininosuccinate lyase
I6G77_RS10010	COG4145	pantothenate transmembrane transporter activity
I6G77_RS10020	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS10035	COG1657	PFAM Prenyltransferase squalene oxidase
I6G77_RS10040	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6G77_RS10045	COG2962	Rard protein
I6G77_RS10050	COG3326	Membrane
I6G77_RS10065	COG0489	protein tyrosine kinase activity
I6G77_RS10075	COG0314	molybdopterin synthase activity
I6G77_RS10080	COG0303	'Molybdopterin
I6G77_RS10085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G77_RS10090	COG2116	formate transmembrane transporter activity
I6G77_RS10100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G77_RS10105	COG5609	conserved protein (DUF2294)
I6G77_RS10110	COG2427	Protein of unknown function (DUF1641)
I6G77_RS10115	COG3383	formate dehydrogenase (NAD+) activity
I6G77_RS10120	COG0697	spore germination
I6G77_RS10135	COG0531	amino acid
I6G77_RS10170	COG2226	methyltransferase
I6G77_RS10180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G77_RS10185	COG4166	transmembrane transport
I6G77_RS10190	COG4166	transmembrane transport
I6G77_RS10195	COG1316	TRANSCRIPTIONal
I6G77_RS10205	COG1595	DNA-templated transcription, initiation
I6G77_RS10210	COG0346	lactoylglutathione lyase activity
I6G77_RS10220	COG1131	(ABC) transporter
I6G77_RS10240	COG0673	inositol 2-dehydrogenase activity
I6G77_RS10245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G77_RS10250	COG0187	DNA topoisomerase II activity
I6G77_RS10255	COG1832	CoA-binding protein
I6G77_RS10260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G77_RS10265	COG0745	RESPONSE REGULATOR receiver
I6G77_RS10285	COG4841	protein insertion into membrane
I6G77_RS10290	COG0824	Thioesterase
I6G77_RS10320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G77_RS10330	COG2274	protein secretion by the type I secretion system
I6G77_RS10335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G77_RS10365	COG2211	Major facilitator Superfamily
I6G77_RS10375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G77_RS10390	COG0183	Belongs to the thiolase family
I6G77_RS10395	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS10400	COG1268	BioY protein
I6G77_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS10420	COG1396	sequence-specific DNA binding
I6G77_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS10470	COG5002	protein histidine kinase activity
I6G77_RS10475	COG0400	carboxylic ester hydrolase activity
I6G77_RS10480	COG0346	lactoylglutathione lyase activity
I6G77_RS10485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G77_RS10495	COG0069	glutamate synthase activity
I6G77_RS10500	COG1902	pentaerythritol trinitrate reductase activity
I6G77_RS10505	COG1329	Transcriptional regulator
I6G77_RS10510	COG0010	Belongs to the arginase family
I6G77_RS10535	COG2226	methyltransferase
I6G77_RS10570	COG4846	Membrane protein involved in cytochrome C biogenesis
I6G77_RS10575	COG0785	Cytochrome C biogenesis protein
I6G77_RS10585	COG1473	amidohydrolase
I6G77_RS10595	COG1131	(ABC) transporter
I6G77_RS10605	COG0583	DNA-binding transcription factor activity
I6G77_RS10615	COG1346	cytolysis
I6G77_RS10630	COG0730	response to heat
I6G77_RS10640	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS10640	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS10655	COG1132	(ABC) transporter
I6G77_RS10660	COG1132	(ABC) transporter
I6G77_RS10685	COG3639	organic phosphonate transmembrane transporter activity
I6G77_RS10695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS10700	COG0737	Belongs to the 5'-nucleotidase family
I6G77_RS10710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G77_RS10730	COG1695	Transcriptional regulator
I6G77_RS10760	COG0174	glutamine synthetase
I6G77_RS10765	COG0789	Transcriptional regulator
I6G77_RS10770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6G77_RS10775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G77_RS10780	COG2860	membrane
I6G77_RS10785	COG0464	growth
I6G77_RS10815	COG3584	3D domain protein
I6G77_RS10815	COG1388	LysM domain
I6G77_RS10820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS10820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G77_RS10820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G77_RS10825	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G77_RS10830	COG1349	DNA-binding transcription factor activity
I6G77_RS10835	COG1979	alcohol dehydrogenase
I6G77_RS10840	COG2322	membrane
I6G77_RS10850	COG1113	amino acid transport
I6G77_RS10860	COG1408	metallophosphoesterase
I6G77_RS10865	COG2116	formate transmembrane transporter activity
I6G77_RS10880	COG2217	Heavy metal translocating P-type atpase
I6G77_RS10885	COG2608	mercury ion transmembrane transporter activity
I6G77_RS10890	COG1937	Protein conserved in bacteria
I6G77_RS10900	COG2819	hydrolase of the alpha beta superfamily
I6G77_RS10905	COG1120	ATPase activity
I6G77_RS10910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS10915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS10920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS10925	COG0708	Exodeoxyribonuclease III
I6G77_RS10930	COG2169	Transcriptional regulator
I6G77_RS10935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G77_RS10940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G77_RS10950	COG2364	Membrane
I6G77_RS10970	COG5001	Diguanylate cyclase
I6G77_RS10970	COG3300	MHYT domain
I6G77_RS11005	COG0384	phenazine biosynthesis protein PhzF
I6G77_RS11015	COG1346	cytolysis
I6G77_RS11020	COG1380	Effector of murein hydrolase LrgA
I6G77_RS11025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS11035	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G77_RS11045	COG2188	Transcriptional regulator
I6G77_RS11050	COG2723	6-phospho-beta-galactosidase activity
I6G77_RS11060	COG1404	Belongs to the peptidase S8 family
I6G77_RS11065	COG3773	Cell wall hydrolase
I6G77_RS11075	COG1368	sulfuric ester hydrolase activity
I6G77_RS11080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6G77_RS11090	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6G77_RS11115	COG1131	(ABC) transporter
I6G77_RS11140	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6G77_RS11150	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G77_RS11155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G77_RS11155	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G77_RS11165	COG2359	stage V sporulation protein S
I6G77_RS11170	COG1692	metallophosphoesterase
I6G77_RS11190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G77_RS11195	COG1426	Protein conserved in bacteria
I6G77_RS11210	COG0300	oxidoreductase activity
I6G77_RS11215	COG0612	Peptidase, M16
I6G77_RS11220	COG0612	Peptidase, M16
I6G77_RS11225	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G77_RS11230	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G77_RS11235	COG3845	ABC transporter
I6G77_RS11240	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G77_RS11245	COG2188	Transcriptional regulator
I6G77_RS11250	COG1674	ftsk spoiiie
I6G77_RS11260	COG0740	serine-type endopeptidase activity
I6G77_RS11265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G77_RS11275	COG0527	aspartate kinase activity
I6G77_RS11280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G77_RS11285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G77_RS11335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G77_RS11340	COG1873	PFAM PRC-barrel domain
I6G77_RS11345	COG0612	Peptidase, M16
I6G77_RS11350	COG0726	polysaccharide deacetylase
I6G77_RS11365	COG0196	riboflavin kinase activity
I6G77_RS11380	COG1550	Protein conserved in bacteria
I6G77_RS11390	COG1358	cellular component organization or biogenesis
I6G77_RS11395	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6G77_RS11400	COG0195	Participates in both transcription termination and antitermination
I6G77_RS11420	COG0750	zinc metalloprotease
I6G77_RS11430	COG4589	Belongs to the CDS family
I6G77_RS11445	COG0528	UMP kinase activity
I6G77_RS11475	COG4974	Belongs to the 'phage' integrase family
I6G77_RS11485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G77_RS11490	COG0758	DNA mediated transformation
I6G77_RS11495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G77_RS11535	COG1837	Belongs to the UPF0109 family
I6G77_RS11545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G77_RS11555	COG0552	protein localization to endoplasmic reticulum
I6G77_RS11560	COG1196	nuclear chromosome segregation
I6G77_RS11570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G77_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS11580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G77_RS11595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G77_RS11600	COG1461	Dihydroxyacetone kinase
I6G77_RS11605	COG1302	Protein conserved in bacteria
I6G77_RS11620	COG1564	THIamine pyrophosphokinase
I6G77_RS11625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G77_RS11635	COG2815	serine threonine protein kinase
I6G77_RS11635	COG0515	serine threonine protein kinase
I6G77_RS11640	COG0631	protein serine/threonine phosphatase activity
I6G77_RS11650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G77_RS11650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G77_RS11660	COG0242	peptide deformylase activity
I6G77_RS11665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G77_RS11670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G77_RS11690	COG1561	YicC-like family, N-terminal region
I6G77_RS11695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G77_RS11710	COG0006	proline dipeptidase activity
I6G77_RS11725	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G77_RS11785	COG0564	pseudouridine synthase activity
I6G77_RS11805	COG3599	regulation of cell shape
I6G77_RS11810	COG2302	S4 RNA-binding domain
I6G77_RS11815	COG0762	integral membrane protein
I6G77_RS11825	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G77_RS11835	COG1873	PFAM PRC-barrel domain
I6G77_RS11840	COG1191	sigma factor activity
I6G77_RS11845	COG1191	sigma factor activity
I6G77_RS11855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G77_RS11860	COG0849	cell division
I6G77_RS11865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G77_RS11880	COG0772	Belongs to the SEDS family
I6G77_RS11895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G77_RS11900	COG0768	penicillin binding
I6G77_RS11905	COG0768	penicillin binding
I6G77_RS11910	COG4839	cell division protein FtsL
I6G77_RS11925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G77_RS11940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G77_RS11945	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G77_RS11955	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G77_RS11960	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G77_RS11965	COG3314	Sporulation integral membrane protein YlbJ
I6G77_RS11975	COG0742	ribosomal rna small subunit methyltransferase
I6G77_RS11990	COG3679	Belongs to the UPF0342 family
I6G77_RS11995	COG0406	alpha-ribazole phosphatase activity
I6G77_RS12010	COG2340	Cysteine-rich secretory protein family
I6G77_RS12020	COG3336	cytochrome c oxidase
I6G77_RS12055	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G77_RS12060	COG0772	Belongs to the SEDS family
I6G77_RS12070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G77_RS12075	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G77_RS12085	COG4896	Protein conserved in bacteria
I6G77_RS12100	COG1217	gtp-binding protein TYPA
I6G77_RS12110	COG0483	inositol monophosphate 1-phosphatase activity
I6G77_RS12130	COG1982	Orn Lys Arg decarboxylase major
I6G77_RS12180	COG0022	dehydrogenase e1 component
I6G77_RS12185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G77_RS12195	COG0242	peptide deformylase activity
I6G77_RS12200	COG0561	phosphatase activity
I6G77_RS12210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G77_RS12215	COG0569	domain protein
I6G77_RS12235	COG0583	DNA-binding transcription factor activity
I6G77_RS12240	COG0517	IMP dehydrogenase activity
I6G77_RS12250	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I6G77_RS12260	COG4703	Protein of unknown function (DUF1797)
I6G77_RS12275	COG2200	EAL domain
I6G77_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS12285	COG1408	metallophosphoesterase
I6G77_RS12295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G77_RS12330	COG2814	Major facilitator Superfamily
I6G77_RS12370	COG3209	COG3209 Rhs family protein
I6G77_RS12380	COG2205	protein histidine kinase activity
I6G77_RS12390	COG0436	Aminotransferase
I6G77_RS12395	COG1609	Transcriptional regulator
I6G77_RS12400	COG3833	ABC-type maltose transport systems, permease component
I6G77_RS12405	COG1175	transmembrane transport
I6G77_RS12410	COG2182	Extracellular solute-binding protein
I6G77_RS12420	COG0366	Alpha amylase catalytic
I6G77_RS12425	COG3842	ATPase activity
I6G77_RS12460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G77_RS12465	COG0183	Belongs to the thiolase family
I6G77_RS12500	COG1695	Transcriptional regulator
I6G77_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS12525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G77_RS12530	COG0436	Aminotransferase
I6G77_RS12565	COG2084	Dehydrogenase
I6G77_RS12575	COG2199	diguanylate cyclase activity
I6G77_RS12580	COG0778	Nitroreductase
I6G77_RS12605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G77_RS12605	COG1263	PTS System
I6G77_RS12605	COG2190	(PTS) system
I6G77_RS12610	COG3711	transcriptional antiterminator
I6G77_RS12620	COG2188	Transcriptional regulator
I6G77_RS12630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G77_RS12655	COG1547	Domain of unknown function (DUF309)
I6G77_RS12660	COG0456	acetyltransferase
I6G77_RS12665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G77_RS12670	COG4086	secreted protein
I6G77_RS12675	COG0561	phosphatase activity
I6G77_RS12680	COG0697	spore germination
I6G77_RS12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G77_RS12720	COG0733	neurotransmitter:sodium symporter activity
I6G77_RS12740	COG1686	Belongs to the peptidase S11 family
I6G77_RS12745	COG1725	Transcriptional regulator
I6G77_RS12750	COG1131	(ABC) transporter
I6G77_RS12770	COG1846	Transcriptional regulator
I6G77_RS12785	COG0598	Magnesium transport protein CorA
I6G77_RS12810	COG4974	Belongs to the 'phage' integrase family
I6G77_RS12820	COG0735	belongs to the Fur family
I6G77_RS12825	COG1300	Membrane
I6G77_RS12845	COG0667	Aldo Keto reductase
I6G77_RS12850	COG0656	L-ascorbic acid biosynthetic process
I6G77_RS12855	COG0456	acetyltransferase
I6G77_RS12855	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G77_RS12865	COG1525	nuclease
I6G77_RS12865	COG4085	toxin activity
I6G77_RS12865	COG0737	Belongs to the 5'-nucleotidase family
I6G77_RS12875	COG0596	Alpha beta hydrolase
I6G77_RS12880	COG2056	Na+-H+ antiporter family
I6G77_RS12885	COG1609	Transcriptional regulator
I6G77_RS12890	COG0456	acetyltransferase
I6G77_RS12895	COG1073	alpha beta
I6G77_RS12910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G77_RS12910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G77_RS12915	COG0307	riboflavin synthase, alpha
I6G77_RS12940	COG4106	trans-aconitate 2-methyltransferase activity
I6G77_RS12945	COG2226	methyltransferase
I6G77_RS12945	COG1073	alpha beta
I6G77_RS12960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G77_RS12970	COG1757	Na H antiporter
I6G77_RS12975	COG0737	Belongs to the 5'-nucleotidase family
I6G77_RS12985	COG1522	sequence-specific DNA binding
I6G77_RS13005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G77_RS13030	COG0300	oxidoreductase activity
I6G77_RS13035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS13040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G77_RS13045	COG1760	l-serine dehydratase
I6G77_RS13050	COG1760	l-serine dehydratase
I6G77_RS13075	COG1285	pathogenesis
I6G77_RS13090	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G77_RS13095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS13110	COG1376	ErfK ybiS ycfS ynhG family protein
I6G77_RS13115	COG4129	membrane
I6G77_RS13120	COG1126	abc transporter atp-binding protein
I6G77_RS13125	COG0765	amino acid transport
I6G77_RS13130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS13150	COG2323	membrane
I6G77_RS13155	COG0772	Belongs to the SEDS family
I6G77_RS13160	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G77_RS13165	COG0022	dehydrogenase e1 component
I6G77_RS13170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G77_RS13175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G77_RS13190	COG0280	phosphate acetyltransferase
I6G77_RS13195	COG3290	protein histidine kinase activity
I6G77_RS13195	COG3829	transcription factor binding
I6G77_RS13205	COG0584	glycerophosphoryl diester phosphodiesterase
I6G77_RS13210	COG3093	addiction module antidote protein HigA
I6G77_RS13215	COG1215	transferase activity, transferring glycosyl groups
I6G77_RS13230	COG0745	RESPONSE REGULATOR receiver
I6G77_RS13235	COG0750	zinc metalloprotease
I6G77_RS13240	COG0497	DNA recombination
I6G77_RS13250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6G77_RS13260	COG0142	geranyltranstransferase activity
I6G77_RS13285	COG1302	Protein conserved in bacteria
I6G77_RS13290	COG0439	Biotin carboxylase
I6G77_RS13295	COG0511	ligase activity, forming carbon-carbon bonds
I6G77_RS13340	COG3854	ATPases associated with a variety of cellular activities
I6G77_RS13365	COG0006	proline dipeptidase activity
I6G77_RS13380	COG3872	metal-dependent enzyme
I6G77_RS13390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G77_RS13420	COG0095	Lipoate-protein ligase
I6G77_RS13425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G77_RS13435	COG1609	Transcriptional regulator
I6G77_RS13445	COG2076	Multidrug Resistance protein
I6G77_RS13450	COG2076	Multidrug Resistance protein
I6G77_RS13485	COG1131	(ABC) transporter
I6G77_RS13490	COG1725	Transcriptional regulator
I6G77_RS13520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G77_RS13585	COG4970	Tfp pilus assembly protein FimT
I6G77_RS13595	COG1459	type II secretion system
I6G77_RS13660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G77_RS13710	COG1410	methionine synthase
I6G77_RS13710	COG0646	methionine synthase
I6G77_RS13715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G77_RS13715	COG0646	methionine synthase
I6G77_RS13720	COG0626	cystathionine gamma-synthase activity
I6G77_RS13725	COG0626	cystathionine gamma-synthase activity
I6G77_RS13745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS13755	COG1940	carbohydrate kinase activity
I6G77_RS13760	COG4483	Protein conserved in bacteria
I6G77_RS13765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G77_RS13770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G77_RS13775	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6G77_RS13780	COG0704	Plays a role in the regulation of phosphate uptake
I6G77_RS13790	COG0581	inorganic phosphate transmembrane transporter activity
I6G77_RS13795	COG0573	inorganic phosphate transmembrane transporter activity
I6G77_RS13800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G77_RS13805	COG0768	penicillin binding
I6G77_RS13810	COG0477	Major facilitator Superfamily
I6G77_RS13815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G77_RS13840	COG0735	belongs to the Fur family
I6G77_RS13845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G77_RS13850	COG1121	(ABC) transporter
I6G77_RS13855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS13885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G77_RS13890	COG2384	SAM-dependent methyltransferase
I6G77_RS13900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G77_RS13905	COG0358	DNA primase activity
I6G77_RS13915	COG0517	IMP dehydrogenase activity
I6G77_RS13930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G77_RS13935	COG0295	cytidine deaminase activity
I6G77_RS13940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G77_RS13950	COG1480	7TM receptor with intracellular HD hydrolase
I6G77_RS13955	COG1702	phosphate starvation-inducible protein PhoH
I6G77_RS13970	COG1610	YqeY-like protein
I6G77_RS13975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G77_RS13980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G77_RS13985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G77_RS14015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G77_RS14020	COG1733	regulation of RNA biosynthetic process
I6G77_RS14045	COG1466	dna polymerase III delta subunit
I6G77_RS14055	COG2333	competence protein COMEC
I6G77_RS14055	COG0658	competence protein
I6G77_RS14060	COG2131	deaminase
I6G77_RS14065	COG1596	polysaccharide export
I6G77_RS14065	COG1555	photosystem II stabilization
I6G77_RS14070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G77_RS14075	COG2226	methyltransferase
I6G77_RS14080	COG0799	negative regulation of ribosome biogenesis
I6G77_RS14085	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6G77_RS14095	COG1534	Rna-binding protein
I6G77_RS14105	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6G77_RS14110	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6G77_RS14135	COG1595	DNA-templated transcription, initiation
I6G77_RS14145	COG0778	Nitroreductase
I6G77_RS14150	COG2357	RelA SpoT domain protein
I6G77_RS14160	COG1785	Belongs to the alkaline phosphatase family
I6G77_RS14170	COG2267	carboxylic ester hydrolase activity
I6G77_RS14210	COG1404	Belongs to the peptidase S8 family
I6G77_RS14215	COG3186	Phenylalanine-4-hydroxylase
I6G77_RS14225	COG2514	catechol 2,3-dioxygenase activity
I6G77_RS14230	COG2259	Doxx family
I6G77_RS14270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS14280	COG1454	alcohol dehydrogenase
I6G77_RS14280	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS14285	COG0626	cystathionine gamma-synthase activity
I6G77_RS14290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G77_RS14315	COG0768	penicillin binding
I6G77_RS14330	COG0826	peptidase U32
I6G77_RS14335	COG0826	peptidase U32
I6G77_RS14340	COG4122	O-methyltransferase activity
I6G77_RS14345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G77_RS14375	COG0628	permease
I6G77_RS14395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G77_RS14410	COG1104	cysteine desulfurase activity
I6G77_RS14415	COG1959	2 iron, 2 sulfur cluster binding
I6G77_RS14420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G77_RS14425	COG0464	growth
I6G77_RS14435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G77_RS14460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G77_RS14470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G77_RS14470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6G77_RS14475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G77_RS14480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G77_RS14480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G77_RS14490	COG2244	polysaccharide biosynthetic process
I6G77_RS14495	COG2323	membrane
I6G77_RS14505	COG1862	Preprotein translocase
I6G77_RS14535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6G77_RS14545	COG0697	spore germination
I6G77_RS14550	COG0640	Transcriptional regulator
I6G77_RS14575	COG0157	Belongs to the NadC ModD family
I6G77_RS14580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G77_RS14585	COG1104	cysteine desulfurase activity
I6G77_RS14590	COG1827	regulation of RNA biosynthetic process
I6G77_RS14595	COG2258	MOSC domain
I6G77_RS14600	COG0077	Prephenate dehydratase
I6G77_RS14605	COG0577	efflux transmembrane transporter activity
I6G77_RS14610	COG0577	efflux transmembrane transporter activity
I6G77_RS14615	COG1136	(ABC) transporter
I6G77_RS14620	COG5002	protein histidine kinase activity
I6G77_RS14625	COG0745	RESPONSE REGULATOR receiver
I6G77_RS14635	COG3290	protein histidine kinase activity
I6G77_RS14645	COG2868	ribosomal protein
I6G77_RS14655	COG1530	ribonuclease E activity
I6G77_RS14660	COG1994	Peptidase M50
I6G77_RS14665	COG0739	heme binding
I6G77_RS14670	COG2894	cell division
I6G77_RS14690	COG1077	Cell shape determining protein MreB Mrl
I6G77_RS14710	COG0285	dihydrofolate synthase activity
I6G77_RS14725	COG1388	LysM domain
I6G77_RS14735	COG0113	porphobilinogen synthase activity
I6G77_RS14740	COG1587	Uroporphyrinogen-III synthase
I6G77_RS14750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G77_RS14760	COG1846	Transcriptional regulator
I6G77_RS14765	COG1764	response to oxidative stress
I6G77_RS14780	COG0470	DNA polymerase III
I6G77_RS14780	COG1067	ATP-dependent peptidase activity
I6G77_RS14825	COG0622	Phosphoesterase
I6G77_RS14840	COG5401	PFAM Sporulation and spore germination
I6G77_RS14850	COG2814	Major facilitator Superfamily
I6G77_RS14860	COG1309	transcriptional regulator
I6G77_RS14875	COG2197	response regulator
I6G77_RS14880	COG2233	PERMEase
I6G77_RS14885	COG0402	S-adenosylhomocysteine deaminase activity
I6G77_RS14890	COG1983	PspC domain protein
I6G77_RS14895	COG1396	sequence-specific DNA binding
I6G77_RS14900	COG0697	spore germination
I6G77_RS14910	COG1959	2 iron, 2 sulfur cluster binding
I6G77_RS14915	COG1668	transmembrane transport
I6G77_RS14920	COG4152	abc transporter atp-binding protein
I6G77_RS14925	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6G77_RS14930	COG1360	Flagellar Motor Protein
I6G77_RS14935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G77_RS14940	COG1876	peptidase activity
I6G77_RS14945	COG0824	Thioesterase
I6G77_RS14950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G77_RS14955	COG1053	succinate dehydrogenase
I6G77_RS14960	COG2009	succinate dehydrogenase
I6G77_RS14965	COG1719	4-vinyl reductase, 4VR
I6G77_RS14975	COG3118	belongs to the thioredoxin family
I6G77_RS14980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G77_RS14985	COG2086	electron transfer activity
I6G77_RS14990	COG1024	Enoyl-CoA hydratase
I6G77_RS14995	COG1309	transcriptional regulator
I6G77_RS15000	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS15010	COG2318	DinB family
I6G77_RS15040	COG1131	(ABC) transporter
I6G77_RS15045	COG2205	protein histidine kinase activity
I6G77_RS15050	COG0745	RESPONSE REGULATOR receiver
I6G77_RS15060	COG4895	conserved protein (DUF2196)
I6G77_RS15065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6G77_RS15075	COG4509	Sortase family
I6G77_RS15080	COG1120	ATPase activity
I6G77_RS15095	COG5386	Cell surface protein
I6G77_RS15105	COG5386	Cell surface protein
I6G77_RS15110	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS15115	COG1187	pseudouridine synthase activity
I6G77_RS15125	COG1796	DNA polymerase
I6G77_RS15125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G77_RS15130	COG1286	toxin biosynthetic process
I6G77_RS15155	COG0443	Heat shock 70 kDa protein
I6G77_RS15165	COG0464	growth
I6G77_RS15200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G77_RS15210	COG1418	mRNA catabolic process
I6G77_RS15220	COG2814	Major facilitator Superfamily
I6G77_RS15225	COG1566	PFAM secretion protein HlyD family protein
I6G77_RS15230	COG1309	transcriptional regulator
I6G77_RS15235	COG1363	Peptidase, m42
I6G77_RS15260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G77_RS15270	COG1484	DNA-dependent DNA replication
I6G77_RS15275	COG3611	Membrane attachment protein
I6G77_RS15285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G77_RS15290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G77_RS15295	COG0237	dephospho-CoA kinase activity
I6G77_RS15300	COG1971	Probably functions as a manganese efflux pump
I6G77_RS15310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G77_RS15310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G77_RS15315	COG5002	protein histidine kinase activity
I6G77_RS15320	COG0745	RESPONSE REGULATOR receiver
I6G77_RS15340	COG0538	isocitrate dehydrogenase activity
I6G77_RS15345	COG0372	Belongs to the citrate synthase family
I6G77_RS15355	COG0628	permease
I6G77_RS15360	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G77_RS15385	COG1725	Transcriptional regulator
I6G77_RS15390	COG0281	malic enzyme
I6G77_RS15395	COG0587	DNA-directed DNA polymerase activity
I6G77_RS15410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6G77_RS15425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G77_RS15435	COG4109	DRTGG domain
I6G77_RS15450	COG0006	proline dipeptidase activity
I6G77_RS15490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS15495	COG0662	Cupin 2, conserved barrel domain protein
I6G77_RS15505	COG1476	TRANSCRIPTIONal
I6G77_RS15520	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS15525	COG0589	response to stress
I6G77_RS15560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS15585	COG0827	DNA restriction-modification system
I6G77_RS15590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G77_RS15595	COG3874	Sporulation protein YtfJ
I6G77_RS15610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6G77_RS15620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G77_RS15635	COG1104	cysteine desulfurase activity
I6G77_RS15645	COG0583	DNA-binding transcription factor activity
I6G77_RS15650	COG0697	spore germination
I6G77_RS15655	COG1309	transcriptional regulator
I6G77_RS15660	COG1956	GAF domain-containing protein
I6G77_RS15665	COG0626	cystathionine gamma-synthase activity
I6G77_RS15700	COG1595	DNA-templated transcription, initiation
I6G77_RS15710	COG0110	maltose O-acetyltransferase activity
I6G77_RS15715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G77_RS15720	COG0454	-acetyltransferase
I6G77_RS15725	COG0517	IMP dehydrogenase activity
I6G77_RS15730	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G77_RS15735	COG2267	carboxylic ester hydrolase activity
I6G77_RS15745	COG0745	RESPONSE REGULATOR receiver
I6G77_RS15745	COG2972	Histidine kinase
I6G77_RS15765	COG3279	Response regulator of the LytR AlgR family
I6G77_RS15795	COG1609	Transcriptional regulator
I6G77_RS15800	COG4851	CamS sex pheromone cAM373 precursor
I6G77_RS15805	COG3118	belongs to the thioredoxin family
I6G77_RS15815	COG2309	aminopeptidase activity
I6G77_RS15840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS15845	COG0697	spore germination
I6G77_RS15850	COG0789	Transcriptional regulator
I6G77_RS15855	COG1695	Transcriptional regulator
I6G77_RS15875	COG1674	ftsk spoiiie
I6G77_RS15890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G77_RS15900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G77_RS15905	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I6G77_RS15910	COG1363	Peptidase, m42
I6G77_RS15920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS15935	COG0510	thiamine kinase activity
I6G77_RS15940	COG1523	belongs to the glycosyl hydrolase 13 family
I6G77_RS15950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G77_RS15955	COG1349	DNA-binding transcription factor activity
I6G77_RS15960	COG1187	pseudouridine synthase activity
I6G77_RS15965	COG2244	polysaccharide biosynthetic process
I6G77_RS15970	COG2081	HI0933 family
I6G77_RS15975	COG2814	Major facilitator Superfamily
I6G77_RS15985	COG3832	glyoxalase III activity
I6G77_RS16005	COG1329	Transcriptional regulator
I6G77_RS16030	COG0314	molybdopterin synthase activity
I6G77_RS16035	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G77_RS16040	COG0303	'Molybdopterin
I6G77_RS16050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G77_RS16055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G77_RS16075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G77_RS16085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G77_RS16125	COG2814	Major facilitator Superfamily
I6G77_RS16130	COG0475	glutathione-regulated potassium exporter activity
I6G77_RS16135	COG0490	domain, Protein
I6G77_RS16140	COG0582	viral genome integration into host DNA
I6G77_RS16150	COG1136	(ABC) transporter
I6G77_RS16170	COG1242	4 iron, 4 sulfur cluster binding
I6G77_RS16175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6G77_RS16180	COG1131	(ABC) transporter
I6G77_RS16190	COG1794	racemase activity, acting on amino acids and derivatives
I6G77_RS16220	COG2267	carboxylic ester hydrolase activity
I6G77_RS16225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G77_RS16230	COG0671	phosphoesterase, PA-phosphatase related
I6G77_RS16235	COG0438	transferase activity, transferring glycosyl groups
I6G77_RS16245	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G77_RS16325	COG5002	protein histidine kinase activity
I6G77_RS16330	COG4191	Histidine kinase
I6G77_RS16335	COG2267	carboxylic ester hydrolase activity
I6G77_RS16340	COG1368	sulfuric ester hydrolase activity
I6G77_RS16355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G77_RS16360	COG1116	anion transmembrane transporter activity
I6G77_RS16365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G77_RS16390	COG0494	nUDIX hydrolase
I6G77_RS16440	COG0288	reversible hydration of carbon dioxide
I6G77_RS16445	COG1271	oxidase subunit
I6G77_RS16450	COG1294	oxidase, subunit
I6G77_RS16475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS16500	COG1842	Phage shock protein A
I6G77_RS16535	COG5002	protein histidine kinase activity
I6G77_RS16540	COG0745	RESPONSE REGULATOR receiver
I6G77_RS16565	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G77_RS16570	COG1597	lipid kinase activity
I6G77_RS16595	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS16605	COG4977	sequence-specific DNA binding
I6G77_RS16615	COG0577	efflux transmembrane transporter activity
I6G77_RS16620	COG1136	(ABC) transporter
I6G77_RS16625	COG2207	Transcriptional regulator
I6G77_RS16625	COG3708	Transcriptional regulator
I6G77_RS16630	COG5658	integral membrane protein
I6G77_RS16635	COG0640	Transcriptional regulator
I6G77_RS16640	COG0745	RESPONSE REGULATOR receiver
I6G77_RS16645	COG2205	protein histidine kinase activity
I6G77_RS16650	COG0577	efflux transmembrane transporter activity
I6G77_RS16655	COG0577	efflux transmembrane transporter activity
I6G77_RS16660	COG1136	(ABC) transporter
I6G77_RS16665	COG0577	efflux transmembrane transporter activity
I6G77_RS16690	COG2188	Transcriptional regulator
I6G77_RS16710	COG3964	amidohydrolase
I6G77_RS16745	COG4948	Mandelate Racemase Muconate Lactonizing
I6G77_RS16755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G77_RS16760	COG0596	Alpha beta hydrolase
I6G77_RS16770	COG1169	isochorismate synthase
I6G77_RS16775	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G77_RS16780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G77_RS16805	COG0058	SHG alpha-glucan phosphorylase activity
I6G77_RS16815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6G77_RS16835	COG1404	Belongs to the peptidase S8 family
I6G77_RS16850	COG1595	DNA-templated transcription, initiation
I6G77_RS16945	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G77_RS16980	COG1285	pathogenesis
I6G77_RS16985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G77_RS17000	COG2155	Conserved Protein
I6G77_RS17005	COG1098	S1 RNA binding domain
I6G77_RS17010	COG0436	Aminotransferase
I6G77_RS17015	COG1522	sequence-specific DNA binding
I6G77_RS17020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G77_RS17025	COG2267	carboxylic ester hydrolase activity
I6G77_RS17035	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G77_RS17055	COG5018	Exonuclease
I6G77_RS17060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G77_RS17080	COG2050	protein possibly involved in aromatic compounds catabolism
I6G77_RS17090	COG1268	BioY protein
I6G77_RS17100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G77_RS17105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G77_RS17120	COG3584	3D domain protein
I6G77_RS17135	COG1252	NADH dehydrogenase
I6G77_RS17145	COG3708	Transcriptional regulator
I6G77_RS17160	COG1683	Conserved Protein
I6G77_RS17185	COG0316	Belongs to the HesB IscA family
I6G77_RS17200	COG1252	NADH dehydrogenase
I6G77_RS17215	COG0390	transport system, permease component
I6G77_RS17220	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G77_RS17240	COG4837	Protein of unknown function (DUF1462)
I6G77_RS17245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6G77_RS17255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G77_RS17260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G77_RS17280	COG1358	cellular component organization or biogenesis
I6G77_RS17290	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G77_RS17300	COG0647	UMP catabolic process
I6G77_RS17310	COG2445	Protein of unknown function DUF86
I6G77_RS17315	COG1494	fructose-1,6-bisphosphatase
I6G77_RS17330	COG4470	Protein conserved in bacteria
I6G77_RS17340	COG0789	Transcriptional regulator
I6G77_RS17345	COG4377	Putative membrane peptidase family (DUF2324)
I6G77_RS17370	COG0739	heme binding
I6G77_RS17380	COG3377	Domain of unknown function (DUF1805)
I6G77_RS17385	COG0737	Belongs to the 5'-nucleotidase family
I6G77_RS17395	COG1695	Transcriptional regulator
I6G77_RS17405	COG0719	Fe-S assembly protein
I6G77_RS17410	COG0822	iron-sulfur transferase activity
I6G77_RS17415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G77_RS17420	COG0719	Fe-S assembly protein
I6G77_RS17425	COG0396	ATPase activity
I6G77_RS17430	COG1464	Belongs to the NlpA lipoprotein family
I6G77_RS17435	COG1464	Belongs to the NlpA lipoprotein family
I6G77_RS17440	COG2011	ABC-type metal ion transport system permease component
I6G77_RS17445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G77_RS17455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G77_RS17460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G77_RS17470	COG1393	Belongs to the ArsC family
I6G77_RS17515	COG1309	transcriptional regulator
I6G77_RS17520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS17525	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS17530	COG0183	Belongs to the thiolase family
I6G77_RS17535	COG1024	Enoyl-CoA hydratase
I6G77_RS17535	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G77_RS17545	COG1686	Belongs to the peptidase S11 family
I6G77_RS17560	COG0011	TIGRFAM Protein of
I6G77_RS17565	COG0840	transmembrane signaling receptor activity
I6G77_RS17585	COG2814	Major facilitator Superfamily
I6G77_RS17590	COG0531	amino acid
I6G77_RS17615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS17655	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS17665	COG1376	ErfK ybiS ycfS ynhG family protein
I6G77_RS17670	COG0745	RESPONSE REGULATOR receiver
I6G77_RS17675	COG5002	protein histidine kinase activity
I6G77_RS17700	COG0840	transmembrane signaling receptor activity
I6G77_RS17705	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G77_RS17710	COG3227	Zinc metalloprotease (Elastase)
I6G77_RS17715	COG1741	Belongs to the pirin family
I6G77_RS17730	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS17735	COG0475	glutathione-regulated potassium exporter activity
I6G77_RS17740	COG0490	domain, Protein
I6G77_RS17745	COG1115	amino acid carrier protein
I6G77_RS17750	COG0783	Belongs to the Dps family
I6G77_RS17765	COG1611	Belongs to the LOG family
I6G77_RS17785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS17790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS17795	COG1115	amino acid carrier protein
I6G77_RS17800	COG1115	amino acid carrier protein
I6G77_RS17805	COG2910	NAD(P)H-binding
I6G77_RS17820	COG0656	L-ascorbic acid biosynthetic process
I6G77_RS17825	COG2814	Major facilitator Superfamily
I6G77_RS17830	COG1733	regulation of RNA biosynthetic process
I6G77_RS17840	COG1252	NADH dehydrogenase
I6G77_RS17845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G77_RS17860	COG0840	transmembrane signaling receptor activity
I6G77_RS17860	COG3290	protein histidine kinase activity
I6G77_RS17870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G77_RS17895	COG0488	(ABC) transporter
I6G77_RS17900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS17970	COG0557	exoribonuclease II activity
I6G77_RS17975	COG1647	Serine aminopeptidase, S33
I6G77_RS17980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G77_RS17985	COG1346	cytolysis
I6G77_RS18020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G77_RS18035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G77_RS18085	COG0582	viral genome integration into host DNA
I6G77_RS18130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G77_RS18145	COG2323	membrane
I6G77_RS18155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS18165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G77_RS18175	COG1051	belongs to the nudix hydrolase family
I6G77_RS18185	COG0492	ferredoxin-NADP+ reductase activity
I6G77_RS18190	COG0457	Tetratricopeptide repeat
I6G77_RS18195	COG0110	maltose O-acetyltransferase activity
I6G77_RS18215	COG1950	PFAM Membrane protein of
I6G77_RS18225	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G77_RS18230	COG0556	nucleotide-excision repair
I6G77_RS18245	COG0789	Transcriptional regulator
I6G77_RS18280	COG0583	DNA-binding transcription factor activity
I6G77_RS18290	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6G77_RS18300	COG1132	(ABC) transporter
I6G77_RS18305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G77_RS18310	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS18310	COG0793	Belongs to the peptidase S41A family
I6G77_RS18315	COG2177	Part of the ABC transporter FtsEX involved in
I6G77_RS18320	COG2884	Cell division ATP-binding protein ftsE
I6G77_RS18340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G77_RS18345	COG1278	Cold shock
I6G77_RS18350	COG1040	competence protein
I6G77_RS18355	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6G77_RS18360	COG1388	LysM domain
I6G77_RS18360	COG0791	NLP P60 protein
I6G77_RS18365	COG1733	regulation of RNA biosynthetic process
I6G77_RS18370	COG1307	EDD domain protein, DegV family
I6G77_RS18375	COG1739	Uncharacterized protein family UPF0029
I6G77_RS18380	COG1316	TRANSCRIPTIONal
I6G77_RS18385	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G77_RS18390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G77_RS18395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G77_RS18405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G77_RS18405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6G77_RS18425	COG1486	melibiose metabolic process
I6G77_RS18430	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G77_RS18435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G77_RS18455	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G77_RS18465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G77_RS18470	COG1301	dicarboxylic acid transport
I6G77_RS18480	COG0346	lactoylglutathione lyase activity
I6G77_RS18485	COG1511	domain protein
I6G77_RS18490	COG0583	DNA-binding transcription factor activity
I6G77_RS18505	COG1271	oxidase subunit
I6G77_RS18510	COG1294	oxidase, subunit
I6G77_RS18515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G77_RS18525	COG1620	l-lactate permease
I6G77_RS18535	COG2389	metal-binding protein
I6G77_RS18545	COG1368	sulfuric ester hydrolase activity
I6G77_RS18555	COG1388	LysM domain
I6G77_RS18555	COG0791	NLP P60 protein
I6G77_RS18560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS18570	COG1215	transferase activity, transferring glycosyl groups
I6G77_RS18575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G77_RS18580	COG3584	3D domain protein
I6G77_RS18580	COG1388	LysM domain
I6G77_RS18605	COG4715	Zinc finger, swim domain protein
I6G77_RS18610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G77_RS18655	COG0577	efflux transmembrane transporter activity
I6G77_RS18660	COG1136	(ABC) transporter
I6G77_RS18690	COG5002	protein histidine kinase activity
I6G77_RS18695	COG0745	RESPONSE REGULATOR receiver
I6G77_RS18700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G77_RS18705	COG4464	protein tyrosine phosphatase activity
I6G77_RS18730	COG0438	transferase activity, transferring glycosyl groups
I6G77_RS18735	COG1134	teichoic acid transport
I6G77_RS18740	COG1682	transport, permease protein
I6G77_RS18745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G77_RS18750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G77_RS18755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G77_RS18755	COG0463	Glycosyl transferase, family 2
I6G77_RS18765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G77_RS18775	COG1609	Transcriptional regulator
I6G77_RS18785	COG0739	heme binding
I6G77_RS18800	COG4555	ABC transporter
I6G77_RS18805	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS18810	COG2385	sporulation resulting in formation of a cellular spore
I6G77_RS18825	COG4836	Membrane
I6G77_RS18830	COG1007	ATP synthesis coupled electron transport
I6G77_RS18835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G77_RS18840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G77_RS18850	COG0839	Belongs to the complex I subunit 6 family
I6G77_RS18870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G77_RS18885	COG5001	Diguanylate cyclase
I6G77_RS18885	COG3300	MHYT domain
I6G77_RS18935	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G77_RS18970	COG0698	ribose 5-phosphate isomerase
I6G77_RS18980	COG2190	(PTS) system
I6G77_RS18985	COG2259	Doxx family
I6G77_RS18990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G77_RS19005	COG0009	L-threonylcarbamoyladenylate synthase
I6G77_RS19020	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G77_RS19040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G77_RS19045	COG1494	fructose-1,6-bisphosphatase
I6G77_RS19065	COG4821	SIS domain
I6G77_RS19085	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS19090	COG1960	acyl-CoA dehydrogenase activity
I6G77_RS19095	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G77_RS19100	COG0183	Belongs to the thiolase family
I6G77_RS19105	COG0247	lactate metabolic process
I6G77_RS19105	COG2181	nitrate reductase activity
I6G77_RS19110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G77_RS19120	COG5001	Diguanylate cyclase
I6G77_RS19120	COG3300	MHYT domain
I6G77_RS19140	COG2197	response regulator
I6G77_RS19145	COG4585	Histidine kinase
I6G77_RS19150	COG0842	Transport permease protein
I6G77_RS19155	COG1131	(ABC) transporter
I6G77_RS19160	COG0024	Methionine aminopeptidase
I6G77_RS19165	COG2234	aminopeptidase activity
I6G77_RS19190	COG1595	DNA-templated transcription, initiation
I6G77_RS19200	COG4506	Protein conserved in bacteria
I6G77_RS19205	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G77_RS19230	COG2814	Major facilitator Superfamily
I6G77_RS19235	COG0789	Transcriptional regulator
I6G77_RS19240	COG0584	glycerophosphoryl diester phosphodiesterase
I6G77_RS19245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G77_RS19255	COG1994	Peptidase M50
I6G77_RS19265	COG1078	dGTPase activity
I6G77_RS19270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS19275	COG1120	ATPase activity
I6G77_RS19280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS19285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS19305	COG0280	phosphate acetyltransferase
I6G77_RS19320	COG3773	Cell wall hydrolase
I6G77_RS19330	COG2363	Small membrane protein
I6G77_RS19340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G77_RS19345	COG2233	PERMEase
I6G77_RS19350	COG0561	phosphatase activity
I6G77_RS19355	COG2814	Major facilitator Superfamily
I6G77_RS19365	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G77_RS19370	COG1131	(ABC) transporter
I6G77_RS19375	COG2755	lipolytic protein G-D-S-L family
I6G77_RS19380	COG1609	Transcriptional regulator
I6G77_RS19390	COG0460	homoserine dehydrogenase
I6G77_RS19400	COG2873	o-acetylhomoserine
I6G77_RS19410	COG1011	Hydrolase
I6G77_RS19415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G77_RS19425	COG2197	response regulator
I6G77_RS19430	COG4585	Histidine kinase
I6G77_RS19430	COG2203	Gaf domain
I6G77_RS19435	COG0351	phosphomethylpyrimidine kinase
I6G77_RS19440	COG3706	GGDEF domain
I6G77_RS19445	COG2879	small protein
I6G77_RS19450	COG1966	Carbon starvation protein
I6G77_RS19455	COG3279	Response regulator of the LytR AlgR family
I6G77_RS19460	COG0477	Major facilitator Superfamily
I6G77_RS19485	COG0840	transmembrane signaling receptor activity
I6G77_RS19495	COG1607	acyl-coa hydrolase
I6G77_RS19510	COG0488	(ABC) transporter
I6G77_RS19530	COG0463	Glycosyl transferase, family 2
I6G77_RS19535	COG1309	transcriptional regulator
I6G77_RS19540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G77_RS19545	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G77_RS19545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G77_RS19550	COG0628	permease
I6G77_RS19565	COG3279	Response regulator of the LytR AlgR family
I6G77_RS19570	COG3275	phosphorelay sensor kinase activity
I6G77_RS19575	COG2814	Major facilitator Superfamily
I6G77_RS19580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G77_RS19585	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I6G77_RS19590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G77_RS19610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G77_RS19615	COG1272	protein, Hemolysin III
I6G77_RS19640	COG1164	Oligoendopeptidase f
I6G77_RS19665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G77_RS19670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6G77_RS19675	COG4853	Protein conserved in bacteria
I6G77_RS19680	COG4863	YycH protein
I6G77_RS19685	COG5002	protein histidine kinase activity
I6G77_RS19690	COG0745	RESPONSE REGULATOR receiver
I6G77_RS19720	COG0305	Participates in initiation and elongation during chromosome replication
I6G77_RS19730	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6G77_RS19735	COG4241	membrane
I6G77_RS19745	COG0629	single-stranded DNA binding
I6G77_RS19755	COG0012	GTP binding
I6G77_RS19760	COG4481	Protein conserved in bacteria
I6G77_RS19765	COG0668	transmembrane transport
I6G77_RS19775	COG1475	DNA binding
I6G77_RS19780	COG1192	Involved in chromosome partitioning
I6G77_RS19805	COG1847	R3H domain protein
I6G77_RS19810	COG0706	membrane insertase activity
I6G77_RS19820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G77_RS19830	COG0592	DNA-directed DNA polymerase activity
I6G77_RS19835	COG2501	S4 domain
I6G77_RS19845	COG0187	DNA topoisomerase II activity
I6G77_RS19850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G77_RS19885	COG0516	GMP reductase activity
I6G77_RS19885	COG0517	IMP dehydrogenase activity
I6G77_RS19890	COG1686	Belongs to the peptidase S11 family
I6G77_RS19920	COG1428	Deoxynucleoside kinase
I6G77_RS19925	COG1428	Deoxynucleoside kinase
I6G77_RS19930	COG1335	isochorismatase
I6G77_RS19935	COG0590	tRNA wobble adenosine to inosine editing
I6G77_RS19945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G77_RS20000	COG1982	Orn Lys Arg decarboxylase major
I6G77_RS20010	COG0470	DNA polymerase III
I6G77_RS20015	COG1774	PSP1 C-terminal conserved region
I6G77_RS20025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6G77_RS20035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G77_RS20040	COG2002	toxin-antitoxin pair type II binding
I6G77_RS20050	COG0084	hydrolase, TatD family'
I6G77_RS20055	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6G77_RS20070	COG4466	Protein conserved in bacteria
I6G77_RS20085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G77_RS20090	COG0251	oxidation-reduction process
I6G77_RS20120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G77_RS20125	COG2002	toxin-antitoxin pair type II binding
I6G77_RS20130	COG2244	polysaccharide biosynthetic process
I6G77_RS20135	COG3956	TIGRFAM MazG family protein
I6G77_RS20140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G77_RS20160	COG1098	S1 RNA binding domain
I6G77_RS20175	COG2208	phosphoserine phosphatase activity
I6G77_RS20185	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G77_RS20190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G77_RS20205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G77_RS20210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G77_RS20215	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G77_RS20220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G77_RS20225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G77_RS20230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G77_RS20235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G77_RS20240	COG1396	sequence-specific DNA binding
I6G77_RS20245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G77_RS20335	COG3880	PFAM UvrB UvrC protein
I6G77_RS20345	COG0542	response to heat
I6G77_RS20350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G77_RS20360	COG4956	integral membrane protein (PIN domain superfamily)
I6G77_RS20380	COG1045	serine acetyltransferase
I6G77_RS20395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G77_RS20400	COG3688	RNA-binding protein containing a PIN domain
I6G77_RS20415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G77_RS20420	COG0250	Participates in transcription elongation, termination and antitermination
I6G77_RS20425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G77_RS20445	COG2813	Specifically methylates the guanine in position
I6G77_RS20460	COG1358	cellular component organization or biogenesis
I6G77_RS20530	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G77_RS20590	COG0201	protein transport
I6G77_RS20600	COG0024	Methionine aminopeptidase
I6G77_RS20610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G77_RS20645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G77_RS20670	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS20675	COG0489	protein tyrosine kinase activity
I6G77_RS20685	COG2194	sulfuric ester hydrolase activity
I6G77_RS20690	COG0726	polysaccharide deacetylase
I6G77_RS20770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6G77_RS20775	COG4856	YbbR-like protein
I6G77_RS20790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G77_RS20825	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS20830	COG0604	alcohol dehydrogenase
I6G77_RS20840	COG0277	FAD linked oxidase domain protein
I6G77_RS20845	COG2271	Major facilitator Superfamily
I6G77_RS20855	COG2814	Major facilitator Superfamily
I6G77_RS20875	COG0601	transmembrane transport
I6G77_RS20880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G77_RS20885	COG0444	Belongs to the ABC transporter superfamily
I6G77_RS20890	COG4608	Belongs to the ABC transporter superfamily
I6G77_RS20895	COG4166	transmembrane transport
I6G77_RS20910	COG4166	transmembrane transport
I6G77_RS20915	COG4166	transmembrane transport
I6G77_RS20920	COG0656	L-ascorbic acid biosynthetic process
I6G77_RS20925	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G77_RS20940	COG4149	molybdate abc transporter
I6G77_RS20945	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G77_RS20950	COG1910	domain protein
I6G77_RS20965	COG0697	spore germination
I6G77_RS20980	COG0204	Acyl-transferase
I6G77_RS20990	COG1609	Transcriptional regulator
I6G77_RS21000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS21010	COG0084	hydrolase, TatD family'
I6G77_RS21020	COG5298	Protein conserved in bacteria
I6G77_RS21045	COG0488	(ABC) transporter
I6G77_RS21050	COG4585	Histidine kinase
I6G77_RS21055	COG2197	response regulator
I6G77_RS21060	COG1131	(ABC) transporter
I6G77_RS21065	COG0842	Transport permease protein
I6G77_RS21065	COG1511	domain protein
I6G77_RS21070	COG0842	Transport permease protein
I6G77_RS21080	COG0747	negative chemotaxis
I6G77_RS21085	COG0747	negative chemotaxis
I6G77_RS21090	COG0601	transmembrane transport
I6G77_RS21095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G77_RS21100	COG0444	Belongs to the ABC transporter superfamily
I6G77_RS21105	COG4608	Belongs to the ABC transporter superfamily
I6G77_RS21110	COG0561	phosphatase activity
I6G77_RS21140	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6G77_RS21145	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G77_RS21155	COG0531	amino acid
I6G77_RS21160	COG2814	Major facilitator Superfamily
I6G77_RS21170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G77_RS21180	COG4294	response to UV
I6G77_RS21185	COG0705	Rhomboid family
I6G77_RS21195	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G77_RS21200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G77_RS21205	COG0864	Transcriptional regulator
I6G77_RS21210	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G77_RS21215	COG2183	response to ionizing radiation
I6G77_RS21310	COG0802	atpase or kinase
I6G77_RS21315	COG1214	PFAM Peptidase M22, glycoprotease
I6G77_RS21320	COG0456	acetyltransferase
I6G77_RS21330	COG0488	(ABC) transporter
I6G77_RS21345	COG1266	CAAX protease self-immunity
I6G77_RS21355	COG0459	protein refolding
I6G77_RS21365	COG2252	PERMEase
I6G77_RS21375	COG5002	protein histidine kinase activity
I6G77_RS21400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G77_RS21430	COG2226	methyltransferase
I6G77_RS21440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G77_RS21450	COG1215	transferase activity, transferring glycosyl groups
I6G77_RS21470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS21475	COG0506	proline dehydrogenase activity
I6G77_RS21495	COG0697	spore germination
I6G77_RS21520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G77_RS21525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G77_RS21530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G77_RS21540	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G77_RS21555	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G77_RS21565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G77_RS21575	COG0151	Belongs to the GarS family
I6G77_RS21600	COG0210	DNA helicase
I6G77_RS21610	COG4851	CamS sex pheromone cAM373 precursor
I6G77_RS21630	COG1335	isochorismatase
I6G77_RS21640	COG2011	ABC-type metal ion transport system permease component
I6G77_RS21645	COG1464	Belongs to the NlpA lipoprotein family
I6G77_RS21660	COG0003	Pfam Anion-transporting ATPase
I6G77_RS21665	COG1846	Transcriptional regulator
I6G77_RS21670	COG4682	membrane
I6G77_RS21690	COG1597	lipid kinase activity
I6G77_RS21695	COG0546	phosphoglycolate phosphatase activity
I6G77_RS21700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G77_RS21710	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS21715	COG2076	Multidrug Resistance protein
I6G77_RS21720	COG2309	aminopeptidase activity
I6G77_RS21735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS21740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G77_RS21745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G77_RS21750	COG5002	protein histidine kinase activity
I6G77_RS21755	COG4807	Protein conserved in bacteria
I6G77_RS21780	COG1757	Na H antiporter
I6G77_RS21785	COG1473	amidohydrolase
I6G77_RS21800	COG0450	alkyl hydroperoxide reductase
I6G77_RS21810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G77_RS21820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS21825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS21830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS21845	COG0166	Belongs to the GPI family
I6G77_RS21870	COG5002	protein histidine kinase activity
I6G77_RS21875	COG4191	Histidine kinase
I6G77_RS21895	COG3541	Predicted nucleotidyltransferase
I6G77_RS21900	COG2814	Major facilitator Superfamily
I6G77_RS21905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G77_RS21905	COG0723	plastoquinol--plastocyanin reductase activity
I6G77_RS21915	COG0765	amino acid transport
I6G77_RS21920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS21930	COG0840	transmembrane signaling receptor activity
I6G77_RS21935	COG0277	FAD linked oxidase domain protein
I6G77_RS21940	COG0366	Alpha amylase catalytic
I6G77_RS21945	COG2190	(PTS) system
I6G77_RS21945	COG1263	PTS System
I6G77_RS21945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G77_RS21975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G77_RS21990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G77_RS22000	COG1116	anion transmembrane transporter activity
I6G77_RS22010	COG0488	(ABC) transporter
I6G77_RS22060	COG2270	Major facilitator Superfamily
I6G77_RS22090	COG2310	stress, protein
I6G77_RS22095	COG2310	stress, protein
I6G77_RS22100	COG2310	stress, protein
I6G77_RS22105	COG0861	Integral membrane protein TerC family
I6G77_RS22115	COG3853	Toxic anion resistance protein (TelA)
I6G77_RS22130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G77_RS22140	COG1295	ribonuclease BN
I6G77_RS22145	COG2217	Heavy metal translocating P-type atpase
I6G77_RS22150	COG0697	spore germination
I6G77_RS22160	COG0681	Belongs to the peptidase S26 family
I6G77_RS22170	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS22185	COG3871	stress protein (general stress protein 26)
I6G77_RS22190	COG0387	Pfam Sodium calcium exchanger
I6G77_RS22200	COG0535	radical SAM domain protein
I6G77_RS22220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G77_RS22240	COG3829	transcription factor binding
I6G77_RS22250	COG0833	amino acid
I6G77_RS22255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G77_RS22285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G77_RS22285	COG1263	PTS System
I6G77_RS22290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G77_RS22310	COG0463	Glycosyl transferase, family 2
I6G77_RS22320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G77_RS22320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G77_RS22335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G77_RS22355	COG1228	amidohydrolase
I6G77_RS22360	COG1090	epimerase
I6G77_RS22390	COG1988	membrane-bound metal-dependent
I6G77_RS22395	COG1194	a g-specific adenine glycosylase
I6G77_RS22420	COG1132	(ABC) transporter
I6G77_RS22425	COG4129	membrane
I6G77_RS22430	COG0067	glutamate synthase
I6G77_RS22430	COG0069	glutamate synthase activity
I6G77_RS22430	COG0070	glutamate synthase
I6G77_RS22440	COG4555	ABC transporter
I6G77_RS22460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G77_RS22465	COG0735	belongs to the Fur family
I6G77_RS22580	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G77_RS22585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G77_RS22595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G77_RS22605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G77_RS22615	COG2766	serine protein kinase
I6G77_RS22625	COG1131	(ABC) transporter
I6G77_RS22715	COG4512	PFAM Accessory gene regulator B
I6G77_RS22725	COG3290	protein histidine kinase activity
I6G77_RS22730	COG3279	Response regulator of the LytR AlgR family
I6G77_RS22745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G77_RS22755	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G77_RS22760	COG2268	Band 7 protein
I6G77_RS22770	COG3290	protein histidine kinase activity
I6G77_RS22775	COG4565	transcriptional regulatory protein
I6G77_RS22780	COG2851	Citrate transporter
I6G77_RS22805	COG0745	RESPONSE REGULATOR receiver
I6G77_RS22810	COG5002	protein histidine kinase activity
I6G77_RS22820	COG4990	cell redox homeostasis
I6G77_RS22830	COG3290	protein histidine kinase activity
I6G77_RS22835	COG4565	transcriptional regulatory protein
I6G77_RS22840	COG3493	citrate carrier protein
I6G77_RS22845	COG0281	malic enzyme
I6G77_RS22855	COG0697	spore germination
I6G77_RS22860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G77_RS22870	COG5002	protein histidine kinase activity
I6G77_RS22875	COG0745	RESPONSE REGULATOR receiver
I6G77_RS22880	COG0456	acetyltransferase
I6G77_RS22880	COG0454	-acetyltransferase
I6G77_RS22885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G77_RS22890	COG3383	formate dehydrogenase (NAD+) activity
I6G77_RS22895	COG2427	Protein of unknown function (DUF1641)
I6G77_RS22910	COG0531	amino acid
I6G77_RS22915	COG0640	Transcriptional regulator
I6G77_RS22920	COG2217	Heavy metal translocating P-type atpase
I6G77_RS22925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G77_RS22940	COG3227	Zinc metalloprotease (Elastase)
I6G77_RS22960	COG2720	vancomycin resistance protein
I6G77_RS22965	COG1316	TRANSCRIPTIONal
I6G77_RS22970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G77_RS22975	COG0346	lactoylglutathione lyase activity
I6G77_RS22980	COG1253	flavin adenine dinucleotide binding
I6G77_RS22985	COG1027	Aspartate ammonia-lyase
I6G77_RS22990	COG1620	l-lactate permease
I6G77_RS23005	COG3104	oligopeptide transport
I6G77_RS23010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G77_RS23015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS23020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G77_RS23030	COG2226	methyltransferase
I6G77_RS23035	COG0156	8-amino-7-oxononanoate synthase activity
I6G77_RS23040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G77_RS23045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G77_RS23055	COG4548	von Willebrand factor, type A
I6G77_RS23060	COG0714	Associated with various cellular activities
I6G77_RS23065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G77_RS23085	COG0531	amino acid
I6G77_RS23090	COG2188	Transcriptional regulator
I6G77_RS23095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G77_RS23095	COG1263	PTS System
I6G77_RS23100	COG0366	Alpha amylase catalytic
I6G77_RS23115	COG0697	spore germination
I6G77_RS23120	COG4585	Histidine kinase
I6G77_RS23125	COG2197	response regulator
I6G77_RS23130	COG1404	Belongs to the peptidase S8 family
I6G77_RS23140	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G77_RS23145	COG1115	amino acid carrier protein
I6G77_RS23150	COG1126	abc transporter atp-binding protein
I6G77_RS23155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS23160	COG0765	amino acid transport
I6G77_RS23165	COG0765	amino acid transport
I6G77_RS23170	COG0833	amino acid
I6G77_RS23195	COG2378	regulation of single-species biofilm formation
I6G77_RS23200	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G77_RS23205	COG5002	protein histidine kinase activity
I6G77_RS23220	COG0659	secondary active sulfate transmembrane transporter activity
I6G77_RS23245	COG0601	transmembrane transport
I6G77_RS23250	COG4608	Belongs to the ABC transporter superfamily
I6G77_RS23260	COG2271	Major facilitator Superfamily
I6G77_RS23265	COG1846	Transcriptional regulator
I6G77_RS23270	COG0477	Major facilitator Superfamily
I6G77_RS23275	COG1609	Transcriptional regulator
I6G77_RS23280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G77_RS23295	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G77_RS23300	COG1879	ABC-type sugar transport system periplasmic component
I6G77_RS23320	COG1063	alcohol dehydrogenase
I6G77_RS23335	COG3568	Endonuclease Exonuclease Phosphatase
I6G77_RS23365	COG0840	transmembrane signaling receptor activity
I6G77_RS23370	COG1388	LysM domain
I6G77_RS23370	COG3584	3D domain protein
I6G77_RS23375	COG1476	TRANSCRIPTIONal
I6G77_RS23390	COG3104	oligopeptide transport
I6G77_RS23395	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS23410	COG1113	amino acid transport
I6G77_RS23415	COG2252	PERMEase
I6G77_RS23430	COG2153	protein acetylation
I6G77_RS23440	COG0569	domain protein
I6G77_RS23440	COG0475	glutathione-regulated potassium exporter activity
I6G77_RS23450	COG1845	cytochrome c oxidase, subunit III
I6G77_RS23455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G77_RS23460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G77_RS23465	COG0833	amino acid
I6G77_RS23470	COG4990	cell redox homeostasis
I6G77_RS23485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G77_RS23490	COG0697	spore germination
I6G77_RS23495	COG0531	amino acid
I6G77_RS23510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G77_RS23515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G77_RS23520	COG1918	ferrous iron import across plasma membrane
I6G77_RS23520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G77_RS23525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G77_RS23530	COG0573	inorganic phosphate transmembrane transporter activity
I6G77_RS23535	COG0581	inorganic phosphate transmembrane transporter activity
I6G77_RS23550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G77_RS23670	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I6G77_RS23690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G77_RS23695	COG1116	anion transmembrane transporter activity
I6G77_RS23700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G77_RS23705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G77_RS23710	COG0352	thiamine-phosphate diphosphorylase activity
I6G77_RS23715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G77_RS23720	COG2104	thiamine diphosphate biosynthetic process
I6G77_RS23730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G77_RS23735	COG0351	phosphomethylpyrimidine kinase
I6G77_RS23775	COG2205	protein histidine kinase activity
I6G77_RS23780	COG2814	Major facilitator Superfamily
I6G77_RS23785	COG1846	Transcriptional regulator
I6G77_RS23810	COG1136	(ABC) transporter
I6G77_RS23825	COG2252	PERMEase
I6G77_RS23830	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS23890	COG0778	Nitroreductase
I6G77_RS23895	COG2719	SpoVR family
I6G77_RS23905	COG3591	Belongs to the peptidase S1B family
I6G77_RS23915	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G77_RS23920	COG1937	Protein conserved in bacteria
I6G77_RS23925	COG0425	Belongs to the sulfur carrier protein TusA family
I6G77_RS23925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G77_RS23930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G77_RS23930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G77_RS23935	COG0425	Belongs to the sulfur carrier protein TusA family
I6G77_RS23940	COG0425	Belongs to the sulfur carrier protein TusA family
I6G77_RS23945	COG0425	Belongs to the sulfur carrier protein TusA family
I6G77_RS23945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G77_RS23955	COG2210	Belongs to the sulfur carrier protein TusA family
I6G77_RS23960	COG0730	response to heat
I6G77_RS23970	COG1316	TRANSCRIPTIONal
I6G77_RS23975	COG0604	alcohol dehydrogenase
I6G77_RS23980	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G77_RS23985	COG2814	Major facilitator Superfamily
I6G77_RS23995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS23995	COG3711	transcriptional antiterminator
I6G77_RS24000	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G77_RS24005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6G77_RS24025	COG3584	3D domain protein
I6G77_RS24025	COG1388	LysM domain
I6G77_RS24030	COG0577	efflux transmembrane transporter activity
I6G77_RS24035	COG1136	(ABC) transporter
I6G77_RS24060	COG0577	efflux transmembrane transporter activity
I6G77_RS24065	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS24070	COG3546	catalase activity
I6G77_RS24105	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS24140	COG0531	amino acid
I6G77_RS24145	COG0475	glutathione-regulated potassium exporter activity
I6G77_RS24155	COG1737	Transcriptional regulator
I6G77_RS24165	COG1263	PTS System
I6G77_RS24165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G77_RS24175	COG2259	Doxx family
I6G77_RS24195	COG1522	sequence-specific DNA binding
I6G77_RS24220	COG2076	Multidrug Resistance protein
I6G77_RS24225	COG1309	transcriptional regulator
I6G77_RS24230	COG2814	Major facilitator Superfamily
I6G77_RS24260	COG1136	(ABC) transporter
I6G77_RS24265	COG0577	efflux transmembrane transporter activity
I6G77_RS24270	COG1136	(ABC) transporter
I6G77_RS24275	COG0577	efflux transmembrane transporter activity
I6G77_RS24290	COG1733	regulation of RNA biosynthetic process
I6G77_RS24315	COG0693	protein deglycase activity
I6G77_RS24325	COG0531	amino acid
I6G77_RS24330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G77_RS24340	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS24345	COG1132	(ABC) transporter
I6G77_RS24350	COG1132	(ABC) transporter
I6G77_RS24355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G77_RS24360	COG0765	amino acid transport
I6G77_RS24365	COG1126	abc transporter atp-binding protein
I6G77_RS24380	COG0189	ligase activity
I6G77_RS24410	COG0028	Belongs to the TPP enzyme family
I6G77_RS24415	COG3527	Alpha-acetolactate decarboxylase
I6G77_RS24430	COG0561	phosphatase activity
I6G77_RS24440	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS24440	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS24445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G77_RS24460	COG0586	Pfam SNARE associated Golgi protein
I6G77_RS24470	COG4978	Transcriptional regulator
I6G77_RS24470	COG0789	Transcriptional regulator
I6G77_RS24480	COG0659	secondary active sulfate transmembrane transporter activity
I6G77_RS24515	COG0653	protein targeting
I6G77_RS24520	COG2244	polysaccharide biosynthetic process
I6G77_RS24530	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS24535	COG4196	transglutaminase domain protein
I6G77_RS24555	COG1024	Enoyl-CoA hydratase
I6G77_RS24575	COG1363	Peptidase, m42
I6G77_RS24625	COG0305	Participates in initiation and elongation during chromosome replication
I6G77_RS24660	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS24685	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G77_RS24705	COG1396	sequence-specific DNA binding
I6G77_RS24710	COG3409	Peptidoglycan-binding domain 1 protein
I6G77_RS24735	COG0477	Major facilitator Superfamily
I6G77_RS24740	COG3290	protein histidine kinase activity
I6G77_RS24745	COG4565	transcriptional regulatory protein
I6G77_RS24750	COG3181	Tripartite tricarboxylate transporter family receptor
I6G77_RS24810	COG0552	protein localization to endoplasmic reticulum
I6G77_RS24825	COG0305	Participates in initiation and elongation during chromosome replication
I6G77_RS24840	COG0305	Participates in initiation and elongation during chromosome replication
I6G77_RS24865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G77_RS24870	COG1288	antiporter activity
I6G77_RS24885	COG0477	Major facilitator Superfamily
I6G77_RS24940	COG1183	phosphatidylcholine synthase activity
I6G77_RS24960	COG2376	Dihydroxyacetone kinase
I6G77_RS24970	COG2376	Dihydroxyacetone kinase
I6G77_RS24980	COG0457	Tetratricopeptide repeat
I6G77_RS24995	COG3437	response regulator, receiver
I6G77_RS24995	COG2770	Histidine kinase
I6G77_RS25080	COG1191	sigma factor activity
I6G77_RS25090	COG2208	phosphoserine phosphatase activity
I6G77_RS25095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G77_RS25100	COG5002	protein histidine kinase activity
I6G77_RS25100	COG0784	Response regulator, receiver
I6G77_RS25100	COG2205	protein histidine kinase activity
I6G77_RS25135	COG2807	transmembrane transport
I6G77_RS25180	COG0420	3'-5' exonuclease activity
I6G77_RS25185	COG4717	serine-type aminopeptidase activity
I6G77_RS25195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G77_RS25200	COG0346	lactoylglutathione lyase activity
I6G77_RS25205	COG0346	lactoylglutathione lyase activity
I6G77_RS25215	COG2267	carboxylic ester hydrolase activity
I6G77_RS25235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6G77_RS25240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G77_RS25250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G77_RS25285	COG3973	AAA domain
I6G77_RS25290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G77_RS25310	COG4980	gas vesicle protein
I6G77_RS25315	COG0537	adenosine 5'-monophosphoramidase activity
I6G77_RS25320	COG1131	(ABC) transporter
I6G77_RS25325	COG4473	ABC transporter
I6G77_RS25340	COG1309	transcriptional regulator
I6G77_RS25350	COG3402	PFAM membrane-flanked domain
I6G77_RS25355	COG3428	Bacterial PH domain
I6G77_RS25375	COG3402	PFAM membrane-flanked domain
I6G77_RS25380	COG3428	Bacterial PH domain
I6G77_RS25385	COG2329	Antibiotic biosynthesis monooxygenase
I6G77_RS25390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G77_RS25405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6G77_RS25430	COG1309	transcriptional regulator
I6G77_RS25435	COG1511	domain protein
I6G77_RS25450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G77_RS25455	COG1609	Transcriptional regulator
I6G77_RS25465	COG1234	tRNA 3'-trailer cleavage
I6G77_RS25470	COG0095	Lipoate-protein ligase
I6G77_RS25480	COG0318	PFAM AMP-dependent synthetase and ligase
I6G77_RS25505	COG1073	alpha beta
I6G77_RS25510	COG1408	metallophosphoesterase
I6G77_RS25515	COG1078	dGTPase activity
I6G77_RS25525	COG0477	Major facilitator Superfamily
I6G77_RS25535	COG1595	DNA-templated transcription, initiation
I6G77_RS25540	COG2207	Transcriptional regulator
I6G77_RS25540	COG3708	Transcriptional regulator
I6G77_RS25555	COG2205	protein histidine kinase activity
I6G77_RS25560	COG0745	RESPONSE REGULATOR receiver
I6G77_RS25585	COG0501	Belongs to the peptidase M48B family
I6G77_RS25590	COG0697	spore germination
I6G77_RS25610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G77_RS25615	COG2224	Isocitrate lyase
I6G77_RS25625	COG1278	Cold shock
I6G77_RS25640	COG4903	ComK protein
I6G77_RS25650	COG0398	Pfam SNARE associated Golgi protein
I6G77_RS25710	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G77_RS25735	COG0367	asparagine synthase
I6G77_RS25745	COG0753	catalase activity
I6G77_RS25750	COG0004	ammonium transporteR
I6G77_RS25775	COG2996	Protein conserved in bacteria
I6G77_RS25780	COG3209	COG3209 Rhs family protein
I6G77_RS25795	COG3209	COG3209 Rhs family protein
I6G77_RS25815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G77_RS25825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6G77_RS25840	COG0561	phosphatase activity
I6G77_RS25865	COG2267	carboxylic ester hydrolase activity
I6G77_RS25880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G77_RS25885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G77_RS25890	COG5504	Zn-dependent protease
I6G77_RS25900	COG0180	Tryptophanyl-tRNA synthetase
I6G77_RS25910	COG4166	transmembrane transport
I6G77_RS25915	COG0601	transmembrane transport
I6G77_RS25920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G77_RS25925	COG0444	Belongs to the ABC transporter superfamily
I6G77_RS25930	COG4608	Belongs to the ABC transporter superfamily
I6G77_RS25935	COG0534	Mate efflux family protein
I6G77_RS25940	COG4166	transmembrane transport
I6G77_RS25955	COG0861	Integral membrane protein TerC family
I6G77_RS25960	COG4862	establishment of competence for transformation
I6G77_RS25965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G77_RS25975	COG1164	Oligoendopeptidase f
I6G77_RS25990	COG2346	COG2346, Truncated hemoglobins
I6G77_RS25995	COG4116	CYTH
I6G77_RS26005	COG2357	RelA SpoT domain protein
I6G77_RS26015	COG0564	pseudouridine synthase activity
I6G77_RS26030	COG0772	Belongs to the SEDS family
I6G77_RS26035	COG1216	Glycosyl transferase, family 2
I6G77_RS26055	COG0463	Glycosyl transferase, family 2
I6G77_RS26055	COG0457	Tetratricopeptide repeat
I6G77_RS26075	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G77_RS26090	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6G77_RS26135	COG2153	protein acetylation
I6G77_RS26145	COG2382	esterase
I6G77_RS26175	COG5492	domain, Protein
I6G77_RS26180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G77_RS26190	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G77_RS26190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G77_RS26225	COG1620	l-lactate permease
I6G77_RS26230	COG5634	Uncharacterized conserved protein (DUF2278)
I6G77_RS26245	COG4640	response to antibiotic
I6G77_RS26290	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G77_RS26300	COG1476	TRANSCRIPTIONal
I6G77_RS26350	COG1686	Belongs to the peptidase S11 family
I6G77_RS26355	COG0681	Belongs to the peptidase S26 family
I6G77_RS26375	COG1396	sequence-specific DNA binding
I6G77_RS26390	COG1012	belongs to the aldehyde dehydrogenase family
I6G77_RS26400	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G77_RS26405	COG1177	transmembrane transport
I6G77_RS26410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G77_RS26420	COG2409	Drug exporters of the RND superfamily
I6G77_RS26430	COG0564	pseudouridine synthase activity
I6G77_RS26440	COG2340	Cysteine-rich secretory protein family
I6G77_RS26445	COG0247	lactate metabolic process
I6G77_RS26450	COG0277	FAD linked oxidase domain protein
I6G77_RS26455	COG3835	regulator
I6G77_RS26465	COG0745	RESPONSE REGULATOR receiver
I6G77_RS26470	COG5002	protein histidine kinase activity
I6G77_RS26475	COG2186	Transcriptional regulator
I6G77_RS26495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G77_RS26505	COG2116	formate transmembrane transporter activity
I6G77_RS26510	COG0861	Integral membrane protein TerC family
I6G77_RS26515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G77_RS26525	COG2030	dehydratase
I6G77_RS26545	COG1028	Short-chain dehydrogenase reductase Sdr
I6G77_RS26550	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6G77_RS26560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G77_RS26575	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G77_RS26580	COG3842	ATPase activity
I6G77_RS26605	COG1349	DNA-binding transcription factor activity
I6G77_RS26615	COG0235	Class ii aldolase
I6G77_RS26625	COG2861	carbohydrate metabolic process
I6G77_RS26635	COG3852	Histidine kinase
I6G77_RS26640	COG1846	Transcriptional regulator
I6G77_RS26650	COG2318	DinB family
I6G77_RS26655	COG5002	protein histidine kinase activity
I6G77_RS26665	COG0720	synthase
I6G77_RS26680	COG4873	Protein conserved in bacteria
I6G77_RS26710	COG1780	Probably involved in ribonucleotide reductase function
I6G77_RS26725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G77_RS26730	COG1725	Transcriptional regulator
I6G77_RS26735	COG1131	(ABC) transporter
I6G77_RS26745	COG1131	(ABC) transporter
I6G77_RS26750	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G77_RS26755	COG1266	CAAX protease self-immunity
I6G77_RS26765	COG1522	sequence-specific DNA binding
I6G77_RS26775	COG1335	isochorismatase
I6G77_RS26785	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G77_RS26790	COG2070	2-Nitropropane dioxygenase
I6G77_RS26795	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6G77_RS26805	COG1696	Membrane protein involved in D-alanine export
I6G77_RS26830	COG0716	FMN binding
I6G77_RS26865	COG0534	Mate efflux family protein
I6G77_RS26885	COG1846	Transcriptional regulator
I6G77_RS26895	COG1301	dicarboxylic acid transport
I6G77_RS26900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G77_RS26905	COG4709	membrane
I6G77_RS26910	COG3874	Sporulation protein YtfJ
I6G77_RS26930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G77_RS26935	COG0028	Belongs to the TPP enzyme family
I6G77_RS26940	COG0440	acetolactate synthase activity
I6G77_RS27015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G77_RS27025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G77_RS27030	COG1183	phosphatidylcholine synthase activity
I6G77_RS27035	COG1368	sulfuric ester hydrolase activity
I6G77_RS27045	COG0019	diaminopimelate decarboxylase activity
I6G77_RS27065	COG0529	Catalyzes the synthesis of activated sulfate
I6G77_RS27070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G77_RS27090	COG1648	precorrin-2 dehydrogenase activity
I6G77_RS27095	COG0733	neurotransmitter:sodium symporter activity
I6G77_RS27120	COG1757	Na H antiporter
I6G77_RS27135	COG4758	membrane
I6G77_RS27140	COG4585	Histidine kinase
I6G77_RS27145	COG2197	response regulator
I6G77_RS27155	COG1114	Component of the transport system for branched-chain amino acids
I6G77_RS27205	COG0730	response to heat
I6G77_RS27210	COG0306	phosphate transporter
I6G77_RS27215	COG1392	Phosphate transport regulator
I6G77_RS27220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G77_RS27235	COG3852	Histidine kinase
I6G77_RS27240	COG1801	Protein of unknown function DUF72
I6G77_RS27250	COG0582	viral genome integration into host DNA
I6G77_RS27255	COG5002	protein histidine kinase activity
I6G77_RS27275	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6G77_RS27275	COG0392	lysyltransferase activity
I6G77_RS27290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G77_RS27295	COG1686	Belongs to the peptidase S11 family
I6G77_RS27300	COG2715	membrane protein required for spore maturation
I6G77_RS27305	COG0700	Nucleoside recognition
I6G77_RS27310	COG0745	RESPONSE REGULATOR receiver
I6G77_RS27315	COG5002	protein histidine kinase activity
I6G77_RS27360	COG1819	glycosyl
I6G77_RS27365	COG0156	8-amino-7-oxononanoate synthase activity
I6G77_RS27370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G77_RS27375	COG1136	(ABC) transporter
I6G77_RS27420	COG2323	membrane
I6G77_RS27450	COG1378	Sugar-specific transcriptional regulator TrmB
I6G77_RS27480	COG0506	proline dehydrogenase activity
I6G77_RS27500	COG2814	Major facilitator Superfamily
I6G77_RS27515	COG1396	sequence-specific DNA binding
I6G77_RS27555	COG1396	sequence-specific DNA binding
I6G77_RS27560	COG3048	D-serine ammonia-lyase activity
I6G77_RS27565	COG1131	(ABC) transporter
I6G77_RS27575	COG4974	Belongs to the 'phage' integrase family
I6G77_RS27600	COG1073	alpha beta
I6G77_RS27605	COG2364	Membrane
I6G77_RS27630	COG0823	Involved in the tonB-independent uptake of proteins
I6G77_RS27635	COG3397	chitin binding
I6G77_RS27645	COG0697	spore germination
I6G77_RS27665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G77_RS27720	COG1988	membrane-bound metal-dependent
I6G77_RS27755	COG0675	Transposase, IS605 OrfB family
I6G77_RS27760	COG2304	oxidoreductase activity
I6G77_RS27805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G77_RS27840	COG3718	enzyme involved in inositol metabolism
I6G77_RS27845	COG0191	fructose-bisphosphate aldolase activity
I6G77_RS27870	COG0673	inositol 2-dehydrogenase activity
I6G77_RS27875	COG2814	Major facilitator Superfamily
I6G77_RS27880	COG1609	Transcriptional regulator
I6G77_RS27915	COG3800	Transcriptional regulator
I6G77_RS27915	COG1396	sequence-specific DNA binding
I6G77_RS27925	COG2003	Belongs to the UPF0758 family
I6G77_RS27985	COG0732	type I restriction modification DNA specificity domain
I6G77_RS27995	COG2801	Transposase and inactivated derivatives
I6G77_RS28005	COG2963	transposase activity
I6G77_RS28115	COG0494	nUDIX hydrolase
I6G77_RS28170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G77_RS28170	COG2755	lipolytic protein G-D-S-L family
I6G77_RS28200	COG3773	Cell wall hydrolase
I6G77_RS28205	COG2197	response regulator
I6G77_RS28210	COG4585	Histidine kinase
I6G77_RS28230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G77_RS28245	COG4377	Putative membrane peptidase family (DUF2324)
I6G77_RS28340	COG3716	PTS system mannose fructose sorbose family IID component
I6G77_RS28345	COG3715	PTS system
I6G77_RS28355	COG1482	cell wall glycoprotein biosynthetic process
I6G77_RS28360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G77_RS28360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G77_RS28360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS28365	COG3711	transcriptional antiterminator
I6G77_RS28365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS28370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G77_RS28385	COG0741	lytic transglycosylase activity
I6G77_RS28385	COG0791	NLP P60 protein
I6G77_RS28425	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G77_RS28450	COG0596	Alpha beta hydrolase
I6G77_RS28505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G77_RS28585	COG2814	Major facilitator Superfamily
I6G77_RS28645	COG1957	nucleoside hydrolase
I6G77_RS28660	COG1309	transcriptional regulator
I6G77_RS28735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G77_RS28760	COG0745	RESPONSE REGULATOR receiver
I6G77_RS28765	COG2205	protein histidine kinase activity
I6G77_RS28770	COG1136	(ABC) transporter
I6G77_RS28775	COG0577	efflux transmembrane transporter activity
I6G77_RS28860	COG1476	TRANSCRIPTIONal
I6G77_RS28880	COG0657	acetylesterase activity
I6G77_RS28915	COG2707	UPF0756 membrane protein
I6G77_RS28925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G77_RS28940	COG0577	efflux transmembrane transporter activity
I6G77_RS28945	COG1136	(ABC) transporter