locus-tag	class	description
HCM98_RS00080	COG3880	PFAM UvrB UvrC protein
HCM98_RS00090	COG0542	response to heat
HCM98_RS00095	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HCM98_RS00105	COG4956	integral membrane protein (PIN domain superfamily)
HCM98_RS00125	COG1045	serine acetyltransferase
HCM98_RS00140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCM98_RS00145	COG3688	RNA-binding protein containing a PIN domain
HCM98_RS00160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCM98_RS00165	COG0250	Participates in transcription elongation, termination and antitermination
HCM98_RS00170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HCM98_RS00190	COG2813	Specifically methylates the guanine in position
HCM98_RS00205	COG1358	cellular component organization or biogenesis
HCM98_RS00275	COG0255	Belongs to the universal ribosomal protein uL29 family
HCM98_RS00335	COG0201	protein transport
HCM98_RS00345	COG0024	Methionine aminopeptidase
HCM98_RS00355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HCM98_RS00390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCM98_RS00415	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS00420	COG0489	protein tyrosine kinase activity
HCM98_RS00430	COG2194	sulfuric ester hydrolase activity
HCM98_RS00435	COG0726	polysaccharide deacetylase
HCM98_RS00515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HCM98_RS00520	COG4856	YbbR-like protein
HCM98_RS00540	COG0596	Alpha beta hydrolase
HCM98_RS00560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HCM98_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS00600	COG2011	ABC-type metal ion transport system permease component
HCM98_RS00605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCM98_RS00610	COG1464	Belongs to the NlpA lipoprotein family
HCM98_RS00615	COG0604	alcohol dehydrogenase
HCM98_RS00625	COG0277	FAD linked oxidase domain protein
HCM98_RS00640	COG2814	Major facilitator Superfamily
HCM98_RS00655	COG0601	transmembrane transport
HCM98_RS00660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCM98_RS00665	COG0444	Belongs to the ABC transporter superfamily
HCM98_RS00670	COG4608	Belongs to the ABC transporter superfamily
HCM98_RS00675	COG4166	transmembrane transport
HCM98_RS00690	COG4166	transmembrane transport
HCM98_RS00695	COG4166	transmembrane transport
HCM98_RS00700	COG0656	L-ascorbic acid biosynthetic process
HCM98_RS00705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCM98_RS00730	COG4149	molybdate abc transporter
HCM98_RS00735	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCM98_RS00740	COG1910	domain protein
HCM98_RS00755	COG0697	spore germination
HCM98_RS00770	COG0204	Acyl-transferase
HCM98_RS00780	COG1609	Transcriptional regulator
HCM98_RS00790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS00800	COG0084	hydrolase, TatD family'
HCM98_RS00810	COG5298	Protein conserved in bacteria
HCM98_RS00835	COG0488	(ABC) transporter
HCM98_RS00840	COG4585	Histidine kinase
HCM98_RS00845	COG2197	response regulator
HCM98_RS00850	COG1131	(ABC) transporter
HCM98_RS00855	COG0842	Transport permease protein
HCM98_RS00855	COG1511	domain protein
HCM98_RS00860	COG0842	Transport permease protein
HCM98_RS00875	COG0747	negative chemotaxis
HCM98_RS00880	COG0601	transmembrane transport
HCM98_RS00885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCM98_RS00890	COG0444	Belongs to the ABC transporter superfamily
HCM98_RS00895	COG4608	Belongs to the ABC transporter superfamily
HCM98_RS00900	COG0561	phosphatase activity
HCM98_RS00940	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCM98_RS00950	COG0531	amino acid
HCM98_RS00955	COG2814	Major facilitator Superfamily
HCM98_RS00965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HCM98_RS00975	COG4294	response to UV
HCM98_RS00980	COG0705	Rhomboid family
HCM98_RS00990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HCM98_RS00995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCM98_RS01000	COG0864	Transcriptional regulator
HCM98_RS01005	COG2337	Toxic component of a toxin-antitoxin (TA) module
HCM98_RS01010	COG2183	response to ionizing radiation
HCM98_RS01105	COG0802	atpase or kinase
HCM98_RS01110	COG1214	PFAM Peptidase M22, glycoprotease
HCM98_RS01115	COG0456	acetyltransferase
HCM98_RS01125	COG0488	(ABC) transporter
HCM98_RS01140	COG1266	CAAX protease self-immunity
HCM98_RS01150	COG0459	protein refolding
HCM98_RS01170	COG2252	PERMEase
HCM98_RS01180	COG5002	protein histidine kinase activity
HCM98_RS01205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCM98_RS01235	COG2226	methyltransferase
HCM98_RS01265	COG1215	transferase activity, transferring glycosyl groups
HCM98_RS01300	COG2205	protein histidine kinase activity
HCM98_RS01305	COG0745	RESPONSE REGULATOR receiver
HCM98_RS01325	COG0697	spore germination
HCM98_RS01350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HCM98_RS01355	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HCM98_RS01360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HCM98_RS01370	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HCM98_RS01385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HCM98_RS01395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HCM98_RS01405	COG0151	Belongs to the GarS family
HCM98_RS01430	COG0210	DNA helicase
HCM98_RS01440	COG4851	CamS sex pheromone cAM373 precursor
HCM98_RS01460	COG1335	isochorismatase
HCM98_RS01470	COG2011	ABC-type metal ion transport system permease component
HCM98_RS01475	COG1464	Belongs to the NlpA lipoprotein family
HCM98_RS01495	COG0003	Pfam Anion-transporting ATPase
HCM98_RS01500	COG1846	Transcriptional regulator
HCM98_RS01505	COG4682	membrane
HCM98_RS01525	COG1597	lipid kinase activity
HCM98_RS01530	COG0546	phosphoglycolate phosphatase activity
HCM98_RS01535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HCM98_RS01545	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS01550	COG2076	Multidrug Resistance protein
HCM98_RS01555	COG2309	aminopeptidase activity
HCM98_RS01585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS01590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HCM98_RS01595	COG0582	viral genome integration into host DNA
HCM98_RS01600	COG1396	sequence-specific DNA binding
HCM98_RS01620	COG1396	sequence-specific DNA binding
HCM98_RS01665	COG2002	toxin-antitoxin pair type II binding
HCM98_RS01755	COG0582	viral genome integration into host DNA
HCM98_RS01760	COG4980	gas vesicle protein
HCM98_RS01760	COG1674	ftsk spoiiie
HCM98_RS01795	COG4626	Terminase
HCM98_RS01795	COG1802	Transcriptional regulator
HCM98_RS01805	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS01875	COG4824	toxin secretion phage lysis holin
HCM98_RS01880	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS01895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCM98_RS01900	COG3852	Histidine kinase
HCM98_RS01905	COG4807	Protein conserved in bacteria
HCM98_RS01940	COG1757	Na H antiporter
HCM98_RS01945	COG1473	amidohydrolase
HCM98_RS01965	COG0450	alkyl hydroperoxide reductase
HCM98_RS01975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HCM98_RS01985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS01990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS01995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS02010	COG0166	Belongs to the GPI family
HCM98_RS02055	COG3541	Predicted nucleotidyltransferase
HCM98_RS02060	COG2814	Major facilitator Superfamily
HCM98_RS02065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS02065	COG0723	plastoquinol--plastocyanin reductase activity
HCM98_RS02075	COG0765	amino acid transport
HCM98_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS02090	COG0840	transmembrane signaling receptor activity
HCM98_RS02095	COG0277	FAD linked oxidase domain protein
HCM98_RS02100	COG0366	Alpha amylase catalytic
HCM98_RS02105	COG1263	PTS System
HCM98_RS02105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCM98_RS02105	COG2190	(PTS) system
HCM98_RS02135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HCM98_RS02150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCM98_RS02160	COG1116	anion transmembrane transporter activity
HCM98_RS02230	COG2270	Major facilitator Superfamily
HCM98_RS02260	COG2310	stress, protein
HCM98_RS02265	COG2310	stress, protein
HCM98_RS02270	COG2310	stress, protein
HCM98_RS02275	COG0861	Integral membrane protein TerC family
HCM98_RS02285	COG3853	Toxic anion resistance protein (TelA)
HCM98_RS02300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HCM98_RS02310	COG1295	ribonuclease BN
HCM98_RS02315	COG2217	Heavy metal translocating P-type atpase
HCM98_RS02320	COG0697	spore germination
HCM98_RS02330	COG0681	Belongs to the peptidase S26 family
HCM98_RS02340	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS02355	COG3871	stress protein (general stress protein 26)
HCM98_RS02360	COG0387	Pfam Sodium calcium exchanger
HCM98_RS02370	COG0535	radical SAM domain protein
HCM98_RS02390	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCM98_RS02410	COG3829	transcription factor binding
HCM98_RS02420	COG0833	amino acid
HCM98_RS02425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCM98_RS02455	COG1263	PTS System
HCM98_RS02455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCM98_RS02460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCM98_RS02480	COG0463	Glycosyl transferase, family 2
HCM98_RS02490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCM98_RS02490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HCM98_RS02505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HCM98_RS02525	COG0402	S-adenosylhomocysteine deaminase activity
HCM98_RS02530	COG1090	epimerase
HCM98_RS02535	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS02565	COG1988	membrane-bound metal-dependent
HCM98_RS02570	COG1194	a g-specific adenine glycosylase
HCM98_RS02595	COG1132	(ABC) transporter
HCM98_RS02600	COG4129	membrane
HCM98_RS02605	COG0067	glutamate synthase
HCM98_RS02605	COG0069	glutamate synthase activity
HCM98_RS02605	COG0070	glutamate synthase
HCM98_RS02615	COG4555	ABC transporter
HCM98_RS02635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HCM98_RS02640	COG0735	belongs to the Fur family
HCM98_RS02740	COG4974	Belongs to the 'phage' integrase family
HCM98_RS02750	COG0322	excinuclease ABC activity
HCM98_RS02855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HCM98_RS02860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HCM98_RS02880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HCM98_RS02890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HCM98_RS02900	COG2766	serine protein kinase
HCM98_RS02920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCM98_RS02930	COG1585	Membrane protein implicated in regulation of membrane protease activity
HCM98_RS02935	COG2268	Band 7 protein
HCM98_RS02945	COG3290	protein histidine kinase activity
HCM98_RS02950	COG4565	transcriptional regulatory protein
HCM98_RS02955	COG2851	Citrate transporter
HCM98_RS02980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HCM98_RS02985	COG3842	ATPase activity
HCM98_RS02990	COG1175	transmembrane transport
HCM98_RS02995	COG0395	ABC-type sugar transport system, permease component
HCM98_RS03015	COG0745	RESPONSE REGULATOR receiver
HCM98_RS03020	COG5002	protein histidine kinase activity
HCM98_RS03030	COG4990	cell redox homeostasis
HCM98_RS03040	COG3290	protein histidine kinase activity
HCM98_RS03045	COG4565	transcriptional regulatory protein
HCM98_RS03050	COG3493	citrate carrier protein
HCM98_RS03055	COG0281	malic enzyme
HCM98_RS03065	COG0697	spore germination
HCM98_RS03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS03080	COG5002	protein histidine kinase activity
HCM98_RS03085	COG0745	RESPONSE REGULATOR receiver
HCM98_RS03090	COG0454	-acetyltransferase
HCM98_RS03090	COG0456	acetyltransferase
HCM98_RS03095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HCM98_RS03100	COG3383	formate dehydrogenase (NAD+) activity
HCM98_RS03105	COG2427	Protein of unknown function (DUF1641)
HCM98_RS03120	COG0531	amino acid
HCM98_RS03125	COG0640	Transcriptional regulator
HCM98_RS03130	COG2217	Heavy metal translocating P-type atpase
HCM98_RS03135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HCM98_RS03150	COG3227	Zinc metalloprotease (Elastase)
HCM98_RS03170	COG2720	vancomycin resistance protein
HCM98_RS03175	COG1316	TRANSCRIPTIONal
HCM98_RS03180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS03185	COG0346	lactoylglutathione lyase activity
HCM98_RS03190	COG1253	flavin adenine dinucleotide binding
HCM98_RS03195	COG1027	Aspartate ammonia-lyase
HCM98_RS03200	COG1620	l-lactate permease
HCM98_RS03215	COG3104	oligopeptide transport
HCM98_RS03220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS03230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS03240	COG2226	methyltransferase
HCM98_RS03245	COG0156	8-amino-7-oxononanoate synthase activity
HCM98_RS03250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCM98_RS03255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HCM98_RS03265	COG4548	von Willebrand factor, type A
HCM98_RS03270	COG0714	Associated with various cellular activities
HCM98_RS03275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCM98_RS03295	COG0531	amino acid
HCM98_RS03300	COG2188	Transcriptional regulator
HCM98_RS03305	COG1263	PTS System
HCM98_RS03305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCM98_RS03310	COG0366	Alpha amylase catalytic
HCM98_RS03325	COG0697	spore germination
HCM98_RS03330	COG4585	Histidine kinase
HCM98_RS03335	COG2197	response regulator
HCM98_RS03350	COG1404	Belongs to the peptidase S8 family
HCM98_RS03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCM98_RS03370	COG1115	amino acid carrier protein
HCM98_RS03375	COG1126	abc transporter atp-binding protein
HCM98_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS03385	COG0765	amino acid transport
HCM98_RS03390	COG0765	amino acid transport
HCM98_RS03395	COG0833	amino acid
HCM98_RS03410	COG1595	DNA-templated transcription, initiation
HCM98_RS03430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCM98_RS03435	COG5002	protein histidine kinase activity
HCM98_RS03450	COG0659	secondary active sulfate transmembrane transporter activity
HCM98_RS03465	COG0747	negative chemotaxis
HCM98_RS03475	COG0601	transmembrane transport
HCM98_RS03480	COG4608	Belongs to the ABC transporter superfamily
HCM98_RS03490	COG2271	Major facilitator Superfamily
HCM98_RS03495	COG1846	Transcriptional regulator
HCM98_RS03500	COG0477	Major facilitator Superfamily
HCM98_RS03505	COG1609	Transcriptional regulator
HCM98_RS03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HCM98_RS03525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCM98_RS03530	COG1879	ABC-type sugar transport system periplasmic component
HCM98_RS03560	COG1063	alcohol dehydrogenase
HCM98_RS03575	COG3568	Endonuclease Exonuclease Phosphatase
HCM98_RS03605	COG0840	transmembrane signaling receptor activity
HCM98_RS03610	COG3584	3D domain protein
HCM98_RS03610	COG1388	LysM domain
HCM98_RS03615	COG1476	TRANSCRIPTIONal
HCM98_RS03635	COG3104	oligopeptide transport
HCM98_RS03640	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS03645	COG1464	Belongs to the NlpA lipoprotein family
HCM98_RS03650	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS03655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCM98_RS03660	COG2011	ABC-type metal ion transport system permease component
HCM98_RS03675	COG1113	amino acid transport
HCM98_RS03680	COG2252	PERMEase
HCM98_RS03695	COG2153	protein acetylation
HCM98_RS03705	COG0569	domain protein
HCM98_RS03705	COG0475	glutathione-regulated potassium exporter activity
HCM98_RS03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCM98_RS03725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HCM98_RS03730	COG0833	amino acid
HCM98_RS03735	COG4990	cell redox homeostasis
HCM98_RS03750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCM98_RS03755	COG0697	spore germination
HCM98_RS03760	COG0531	amino acid
HCM98_RS03775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCM98_RS03780	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCM98_RS03785	COG1918	ferrous iron import across plasma membrane
HCM98_RS03785	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HCM98_RS03790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCM98_RS03795	COG0573	inorganic phosphate transmembrane transporter activity
HCM98_RS03800	COG0581	inorganic phosphate transmembrane transporter activity
HCM98_RS03810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCM98_RS03930	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HCM98_RS03960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCM98_RS03965	COG1116	anion transmembrane transporter activity
HCM98_RS03970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCM98_RS03975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCM98_RS03980	COG0352	thiamine-phosphate diphosphorylase activity
HCM98_RS03985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS03990	COG2104	thiamine diphosphate biosynthetic process
HCM98_RS04000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCM98_RS04005	COG0351	phosphomethylpyrimidine kinase
HCM98_RS04045	COG2205	protein histidine kinase activity
HCM98_RS04050	COG2814	Major facilitator Superfamily
HCM98_RS04055	COG1846	Transcriptional regulator
HCM98_RS04070	COG2252	PERMEase
HCM98_RS04075	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS04095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCM98_RS04135	COG0778	Nitroreductase
HCM98_RS04140	COG2719	SpoVR family
HCM98_RS04150	COG3591	Belongs to the peptidase S1B family
HCM98_RS04175	COG0446	pyridine nucleotide-disulphide oxidoreductase
HCM98_RS04180	COG1937	Protein conserved in bacteria
HCM98_RS04185	COG0425	Belongs to the sulfur carrier protein TusA family
HCM98_RS04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCM98_RS04190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS04190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCM98_RS04195	COG0425	Belongs to the sulfur carrier protein TusA family
HCM98_RS04200	COG0425	Belongs to the sulfur carrier protein TusA family
HCM98_RS04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCM98_RS04210	COG2210	Belongs to the sulfur carrier protein TusA family
HCM98_RS04215	COG0730	response to heat
HCM98_RS04225	COG1316	TRANSCRIPTIONal
HCM98_RS04230	COG0604	alcohol dehydrogenase
HCM98_RS04235	COG1283	sodium-dependent phosphate transmembrane transporter activity
HCM98_RS04240	COG2814	Major facilitator Superfamily
HCM98_RS04250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCM98_RS04250	COG3711	transcriptional antiterminator
HCM98_RS04255	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCM98_RS04260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCM98_RS04265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCM98_RS04280	COG1388	LysM domain
HCM98_RS04280	COG3584	3D domain protein
HCM98_RS04285	COG0577	efflux transmembrane transporter activity
HCM98_RS04290	COG1136	(ABC) transporter
HCM98_RS04315	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS04320	COG3546	catalase activity
HCM98_RS04355	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS04375	COG0531	amino acid
HCM98_RS04380	COG0475	glutathione-regulated potassium exporter activity
HCM98_RS04390	COG1737	Transcriptional regulator
HCM98_RS04400	COG1263	PTS System
HCM98_RS04400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCM98_RS04410	COG2259	Doxx family
HCM98_RS04430	COG1522	sequence-specific DNA binding
HCM98_RS04450	COG1309	transcriptional regulator
HCM98_RS04455	COG2814	Major facilitator Superfamily
HCM98_RS04460	COG1733	regulation of RNA biosynthetic process
HCM98_RS04470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCM98_RS04490	COG2211	Major facilitator Superfamily
HCM98_RS04500	COG0693	protein deglycase activity
HCM98_RS04505	COG0753	catalase activity
HCM98_RS04515	COG0531	amino acid
HCM98_RS04520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HCM98_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS04535	COG1132	(ABC) transporter
HCM98_RS04540	COG1132	(ABC) transporter
HCM98_RS04545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS04550	COG0765	amino acid transport
HCM98_RS04555	COG1126	abc transporter atp-binding protein
HCM98_RS04570	COG0189	ligase activity
HCM98_RS04600	COG0028	Belongs to the TPP enzyme family
HCM98_RS04605	COG3527	Alpha-acetolactate decarboxylase
HCM98_RS04615	COG0561	phosphatase activity
HCM98_RS04625	COG3409	Peptidoglycan-binding domain 1 protein
HCM98_RS04625	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS04630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCM98_RS04650	COG0659	secondary active sulfate transmembrane transporter activity
HCM98_RS04690	COG1160	GTP binding
HCM98_RS04715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HCM98_RS04720	COG1288	antiporter activity
HCM98_RS04735	COG0477	Major facilitator Superfamily
HCM98_RS04825	COG1183	phosphatidylcholine synthase activity
HCM98_RS04850	COG2376	Dihydroxyacetone kinase
HCM98_RS04860	COG2376	Dihydroxyacetone kinase
HCM98_RS04875	COG1959	2 iron, 2 sulfur cluster binding
HCM98_RS04905	COG2770	Histidine kinase
HCM98_RS04905	COG3437	response regulator, receiver
HCM98_RS04930	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS04970	COG1136	(ABC) transporter
HCM98_RS04975	COG0577	efflux transmembrane transporter activity
HCM98_RS04980	COG0596	Alpha beta hydrolase
HCM98_RS05000	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS05005	COG3237	CsbD-like
HCM98_RS05030	COG1191	sigma factor activity
HCM98_RS05040	COG2208	phosphoserine phosphatase activity
HCM98_RS05045	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCM98_RS05050	COG0784	Response regulator, receiver
HCM98_RS05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS05050	COG2198	Histidine kinase
HCM98_RS05050	COG2205	protein histidine kinase activity
HCM98_RS05120	COG0420	3'-5' exonuclease activity
HCM98_RS05125	COG4717	serine-type aminopeptidase activity
HCM98_RS05180	COG0346	lactoylglutathione lyase activity
HCM98_RS05185	COG0346	lactoylglutathione lyase activity
HCM98_RS05190	COG0457	Tetratricopeptide repeat
HCM98_RS05195	COG2267	carboxylic ester hydrolase activity
HCM98_RS05225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HCM98_RS05230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HCM98_RS05240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HCM98_RS05285	COG0477	Major facilitator Superfamily
HCM98_RS05290	COG0477	Major facilitator Superfamily
HCM98_RS05300	COG1033	growth of symbiont in host cell
HCM98_RS05300	COG2409	Drug exporters of the RND superfamily
HCM98_RS05350	COG4980	gas vesicle protein
HCM98_RS05355	COG0537	adenosine 5'-monophosphoramidase activity
HCM98_RS05360	COG1131	(ABC) transporter
HCM98_RS05365	COG4473	ABC transporter
HCM98_RS05395	COG1309	transcriptional regulator
HCM98_RS05405	COG3402	PFAM membrane-flanked domain
HCM98_RS05410	COG3428	Bacterial PH domain
HCM98_RS05450	COG3402	PFAM membrane-flanked domain
HCM98_RS05455	COG3428	Bacterial PH domain
HCM98_RS05460	COG2329	Antibiotic biosynthesis monooxygenase
HCM98_RS05465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCM98_RS05480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HCM98_RS05505	COG1309	transcriptional regulator
HCM98_RS05510	COG1511	domain protein
HCM98_RS05535	COG2318	DinB family
HCM98_RS05540	COG2378	regulation of single-species biofilm formation
HCM98_RS05545	COG1609	Transcriptional regulator
HCM98_RS05555	COG1234	tRNA 3'-trailer cleavage
HCM98_RS05560	COG0095	Lipoate-protein ligase
HCM98_RS05570	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS05580	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS05590	COG3209	COG3209 Rhs family protein
HCM98_RS05620	COG1309	transcriptional regulator
HCM98_RS05625	COG1073	alpha beta
HCM98_RS05630	COG1408	metallophosphoesterase
HCM98_RS05640	COG1078	dGTPase activity
HCM98_RS05650	COG0477	Major facilitator Superfamily
HCM98_RS05660	COG0477	Major facilitator Superfamily
HCM98_RS05670	COG1595	DNA-templated transcription, initiation
HCM98_RS05675	COG3708	Transcriptional regulator
HCM98_RS05675	COG2207	Transcriptional regulator
HCM98_RS05680	COG2205	protein histidine kinase activity
HCM98_RS05685	COG0745	RESPONSE REGULATOR receiver
HCM98_RS05710	COG0501	Belongs to the peptidase M48B family
HCM98_RS05715	COG0697	spore germination
HCM98_RS05735	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HCM98_RS05740	COG2224	Isocitrate lyase
HCM98_RS05750	COG1278	Cold shock
HCM98_RS05765	COG4903	ComK protein
HCM98_RS05770	COG0398	Pfam SNARE associated Golgi protein
HCM98_RS05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HCM98_RS05855	COG0367	asparagine synthase
HCM98_RS05865	COG0753	catalase activity
HCM98_RS05870	COG0004	ammonium transporteR
HCM98_RS05895	COG2996	Protein conserved in bacteria
HCM98_RS05900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCM98_RS05910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS05925	COG0561	phosphatase activity
HCM98_RS05945	COG2267	carboxylic ester hydrolase activity
HCM98_RS05960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS05965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HCM98_RS05970	COG5504	Zn-dependent protease
HCM98_RS05980	COG0180	Tryptophanyl-tRNA synthetase
HCM98_RS05990	COG4166	transmembrane transport
HCM98_RS05995	COG0601	transmembrane transport
HCM98_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HCM98_RS06005	COG0444	Belongs to the ABC transporter superfamily
HCM98_RS06010	COG4608	Belongs to the ABC transporter superfamily
HCM98_RS06015	COG0534	Mate efflux family protein
HCM98_RS06035	COG0861	Integral membrane protein TerC family
HCM98_RS06040	COG4862	establishment of competence for transformation
HCM98_RS06045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCM98_RS06055	COG1164	Oligoendopeptidase f
HCM98_RS06070	COG2346	COG2346, Truncated hemoglobins
HCM98_RS06075	COG4116	CYTH
HCM98_RS06085	COG2357	RelA SpoT domain protein
HCM98_RS06095	COG0564	pseudouridine synthase activity
HCM98_RS06110	COG0772	Belongs to the SEDS family
HCM98_RS06115	COG1216	Glycosyl transferase, family 2
HCM98_RS06135	COG0463	Glycosyl transferase, family 2
HCM98_RS06135	COG0457	Tetratricopeptide repeat
HCM98_RS06155	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HCM98_RS06170	COG1091	dTDP-4-dehydrorhamnose reductase activity
HCM98_RS06215	COG2153	protein acetylation
HCM98_RS06225	COG2382	esterase
HCM98_RS06240	COG5492	domain, Protein
HCM98_RS06245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCM98_RS06255	COG0512	Glutamine amidotransferase of anthranilate synthase
HCM98_RS06255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HCM98_RS06290	COG1620	l-lactate permease
HCM98_RS06295	COG5634	Uncharacterized conserved protein (DUF2278)
HCM98_RS06340	COG2226	methyltransferase
HCM98_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCM98_RS06370	COG1476	TRANSCRIPTIONal
HCM98_RS06505	COG2226	methyltransferase
HCM98_RS06515	COG1686	Belongs to the peptidase S11 family
HCM98_RS06520	COG0681	Belongs to the peptidase S26 family
HCM98_RS06540	COG1396	sequence-specific DNA binding
HCM98_RS06555	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS06565	COG1176	ABC-type spermidine putrescine transport system, permease component I
HCM98_RS06570	COG1177	transmembrane transport
HCM98_RS06575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HCM98_RS06585	COG2409	Drug exporters of the RND superfamily
HCM98_RS06595	COG0564	pseudouridine synthase activity
HCM98_RS06605	COG2340	Cysteine-rich secretory protein family
HCM98_RS06610	COG0247	lactate metabolic process
HCM98_RS06615	COG0277	FAD linked oxidase domain protein
HCM98_RS06620	COG3835	regulator
HCM98_RS06630	COG0745	RESPONSE REGULATOR receiver
HCM98_RS06635	COG5002	protein histidine kinase activity
HCM98_RS06640	COG2186	Transcriptional regulator
HCM98_RS06660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HCM98_RS06670	COG2116	formate transmembrane transporter activity
HCM98_RS06675	COG0861	Integral membrane protein TerC family
HCM98_RS06680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCM98_RS06690	COG2030	dehydratase
HCM98_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS06715	COG3243	poly(R)-hydroxyalkanoic acid synthase
HCM98_RS06725	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCM98_RS06740	COG1840	ABC-type Fe3 transport system, periplasmic component
HCM98_RS06745	COG3842	ATPase activity
HCM98_RS06770	COG1349	DNA-binding transcription factor activity
HCM98_RS06780	COG0235	Class ii aldolase
HCM98_RS06790	COG2861	carbohydrate metabolic process
HCM98_RS06800	COG3852	Histidine kinase
HCM98_RS06805	COG1846	Transcriptional regulator
HCM98_RS06815	COG2318	DinB family
HCM98_RS06820	COG5002	protein histidine kinase activity
HCM98_RS06830	COG0720	synthase
HCM98_RS06845	COG4873	Protein conserved in bacteria
HCM98_RS06875	COG1780	Probably involved in ribonucleotide reductase function
HCM98_RS06890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HCM98_RS06895	COG1725	Transcriptional regulator
HCM98_RS06900	COG1131	(ABC) transporter
HCM98_RS06910	COG1131	(ABC) transporter
HCM98_RS06915	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCM98_RS06920	COG1266	CAAX protease self-immunity
HCM98_RS06930	COG1522	sequence-specific DNA binding
HCM98_RS06940	COG1335	isochorismatase
HCM98_RS06950	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCM98_RS06955	COG2070	2-Nitropropane dioxygenase
HCM98_RS06960	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCM98_RS06970	COG1696	Membrane protein involved in D-alanine export
HCM98_RS06995	COG0716	FMN binding
HCM98_RS07030	COG0534	Mate efflux family protein
HCM98_RS07050	COG1846	Transcriptional regulator
HCM98_RS07060	COG1301	dicarboxylic acid transport
HCM98_RS07065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HCM98_RS07070	COG4709	membrane
HCM98_RS07075	COG3874	Sporulation protein YtfJ
HCM98_RS07095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCM98_RS07100	COG0028	Belongs to the TPP enzyme family
HCM98_RS07105	COG0440	acetolactate synthase activity
HCM98_RS07180	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCM98_RS07195	COG1183	phosphatidylcholine synthase activity
HCM98_RS07200	COG1368	sulfuric ester hydrolase activity
HCM98_RS07205	COG0582	viral genome integration into host DNA
HCM98_RS07230	COG1396	sequence-specific DNA binding
HCM98_RS07240	COG3645	SOS response
HCM98_RS07240	COG3646	Phage regulatory protein
HCM98_RS07335	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS07350	COG0582	viral genome integration into host DNA
HCM98_RS07355	COG4980	gas vesicle protein
HCM98_RS07355	COG1674	ftsk spoiiie
HCM98_RS07390	COG1802	Transcriptional regulator
HCM98_RS07390	COG4626	Terminase
HCM98_RS07400	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS07405	COG0740	serine-type endopeptidase activity
HCM98_RS07465	COG0551	DNA topoisomerase type I activity
HCM98_RS07465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCM98_RS07470	COG3344	reverse transcriptase
HCM98_RS07475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCM98_RS07475	COG0551	DNA topoisomerase type I activity
HCM98_RS07490	COG2002	toxin-antitoxin pair type II binding
HCM98_RS07495	COG1923	regulation of RNA biosynthetic process
HCM98_RS07520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HCM98_RS07525	COG5433	transposase activity
HCM98_RS07615	COG0019	diaminopimelate decarboxylase activity
HCM98_RS07635	COG0529	Catalyzes the synthesis of activated sulfate
HCM98_RS07640	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCM98_RS07660	COG1648	precorrin-2 dehydrogenase activity
HCM98_RS07665	COG0733	neurotransmitter:sodium symporter activity
HCM98_RS07690	COG1757	Na H antiporter
HCM98_RS07705	COG4758	membrane
HCM98_RS07710	COG4585	Histidine kinase
HCM98_RS07715	COG2197	response regulator
HCM98_RS07725	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS07735	COG2226	methyltransferase
HCM98_RS07775	COG0730	response to heat
HCM98_RS07780	COG0306	phosphate transporter
HCM98_RS07785	COG1392	Phosphate transport regulator
HCM98_RS07790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCM98_RS07805	COG3852	Histidine kinase
HCM98_RS07810	COG1801	Protein of unknown function DUF72
HCM98_RS07820	COG0582	viral genome integration into host DNA
HCM98_RS07825	COG5002	protein histidine kinase activity
HCM98_RS07840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HCM98_RS07840	COG0392	lysyltransferase activity
HCM98_RS07855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCM98_RS07860	COG1686	Belongs to the peptidase S11 family
HCM98_RS07865	COG2715	membrane protein required for spore maturation
HCM98_RS07870	COG0700	Nucleoside recognition
HCM98_RS07875	COG1187	pseudouridine synthase activity
HCM98_RS07885	COG1333	cytochrome c biogenesis protein
HCM98_RS07890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCM98_RS07895	COG0745	RESPONSE REGULATOR receiver
HCM98_RS07900	COG5002	protein histidine kinase activity
HCM98_RS07905	COG2096	Adenosyltransferase
HCM98_RS07910	COG4942	peptidase
HCM98_RS07920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HCM98_RS07925	COG1141	Ferredoxin
HCM98_RS07935	COG0514	ATP-dependent DNA helicase (RecQ)
HCM98_RS07940	COG1266	CAAX protease self-immunity
HCM98_RS07950	COG1408	metallophosphoesterase
HCM98_RS07960	COG4862	establishment of competence for transformation
HCM98_RS07965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HCM98_RS07985	COG0492	ferredoxin-NADP+ reductase activity
HCM98_RS07990	COG0252	asparaginase activity
HCM98_RS08060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCM98_RS08075	COG0142	geranyltranstransferase activity
HCM98_RS08085	COG0142	geranyltranstransferase activity
HCM98_RS08110	COG0457	Tetratricopeptide repeat
HCM98_RS08130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCM98_RS08135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HCM98_RS08135	COG2010	Cytochrome c
HCM98_RS08140	COG4347	Protein of unknown function (DUF1405)
HCM98_RS08155	COG2738	Putative neutral zinc metallopeptidase
HCM98_RS08165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS08170	COG1694	Mazg nucleotide pyrophosphohydrolase
HCM98_RS08190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCM98_RS08195	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS08230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HCM98_RS08230	COG1199	ATP-dependent helicase activity
HCM98_RS08250	COG3935	DnaD domain protein
HCM98_RS08255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HCM98_RS08265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCM98_RS08265	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCM98_RS08325	COG0116	Belongs to the methyltransferase superfamily
HCM98_RS08335	COG1199	ATP-dependent helicase activity
HCM98_RS08340	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HCM98_RS08350	COG0024	Methionine aminopeptidase
HCM98_RS08360	COG2233	PERMEase
HCM98_RS08365	COG2311	Membrane
HCM98_RS08370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCM98_RS08380	COG0456	acetyltransferase
HCM98_RS08415	COG0754	glutathionylspermidine amidase activity
HCM98_RS08430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCM98_RS08445	COG0454	-acetyltransferase
HCM98_RS08465	COG0328	RNA-DNA hybrid ribonuclease activity
HCM98_RS08500	COG3403	YqcI/YcgG family
HCM98_RS08505	COG1280	lysine exporter protein (LysE YggA)
HCM98_RS08520	COG3162	membrane
HCM98_RS08525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCM98_RS08530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCM98_RS08540	COG0475	glutathione-regulated potassium exporter activity
HCM98_RS08545	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCM98_RS08550	COG4978	Transcriptional regulator
HCM98_RS08550	COG0789	Transcriptional regulator
HCM98_RS08560	COG2323	membrane
HCM98_RS08565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HCM98_RS08630	COG1923	regulation of RNA biosynthetic process
HCM98_RS08640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCM98_RS08650	COG2201	protein-glutamate methylesterase activity
HCM98_RS08655	COG2198	Histidine kinase
HCM98_RS08655	COG0643	Histidine kinase
HCM98_RS08660	COG1776	CheC inhibitor of MCP methylation
HCM98_RS08660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCM98_RS08675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HCM98_RS08695	COG1256	bacterial-type flagellum assembly
HCM98_RS08700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCM98_RS08705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HCM98_RS08720	COG1815	bacterial-type flagellum-dependent cell motility
HCM98_RS08725	COG1558	bacterial-type flagellum-dependent cell motility
HCM98_RS08740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCM98_RS08750	COG1157	protein secretion by the type III secretion system
HCM98_RS08785	COG0835	chemotaxis
HCM98_RS08785	COG0784	Response regulator, receiver
HCM98_RS08795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCM98_RS08800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HCM98_RS08805	COG0741	lytic transglycosylase activity
HCM98_RS08815	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCM98_RS08820	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HCM98_RS08820	COG1776	CheC inhibitor of MCP methylation
HCM98_RS08830	COG1338	Plays a role in the flagellum-specific transport system
HCM98_RS08835	COG1987	bacterial-type flagellum assembly
HCM98_RS08845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCM98_RS08850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HCM98_RS08855	COG1419	protein localization to endoplasmic reticulum
HCM98_RS08860	COG4786	Flagellar basal body rod
HCM98_RS08865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCM98_RS08890	COG1309	transcriptional regulator
HCM98_RS08910	COG2329	Antibiotic biosynthesis monooxygenase
HCM98_RS08925	COG3764	Sortase (surface protein transpeptidase)
HCM98_RS08930	COG3764	Sortase (surface protein transpeptidase)
HCM98_RS08960	COG0583	DNA-binding transcription factor activity
HCM98_RS08970	COG0725	ABC transporter, periplasmic molybdate-binding protein
HCM98_RS09020	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS09025	COG0406	alpha-ribazole phosphatase activity
HCM98_RS09045	COG1846	Transcriptional regulator
HCM98_RS09055	COG0367	asparagine synthase
HCM98_RS09085	COG1802	Transcriptional regulator
HCM98_RS09090	COG0697	spore germination
HCM98_RS09095	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS09095	COG1216	Glycosyl transferase, family 2
HCM98_RS09100	COG1757	Na H antiporter
HCM98_RS09110	COG0114	fumarate hydratase activity
HCM98_RS09130	COG0534	Mate efflux family protein
HCM98_RS09135	COG3340	Belongs to the peptidase S51 family
HCM98_RS09155	COG0785	Cytochrome C biogenesis protein
HCM98_RS09180	COG2733	membrane
HCM98_RS09215	COG1131	(ABC) transporter
HCM98_RS09230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCM98_RS09235	COG0528	UMP kinase activity
HCM98_RS09245	COG1027	Aspartate ammonia-lyase
HCM98_RS09250	COG0281	malic enzyme
HCM98_RS09255	COG4191	Histidine kinase
HCM98_RS09260	COG0784	Response regulator, receiver
HCM98_RS09265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCM98_RS09305	COG1051	belongs to the nudix hydrolase family
HCM98_RS09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS09335	COG2814	Major facilitator Superfamily
HCM98_RS09360	COG0477	Major facilitator Superfamily
HCM98_RS09365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS09385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCM98_RS09390	COG4166	transmembrane transport
HCM98_RS09395	COG2223	nitrite transmembrane transporter activity
HCM98_RS09400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCM98_RS09415	COG2244	polysaccharide biosynthetic process
HCM98_RS09420	COG0733	neurotransmitter:sodium symporter activity
HCM98_RS09430	COG5566	PFAM Mor transcription activator
HCM98_RS09435	COG2323	membrane
HCM98_RS09455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCM98_RS09460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCM98_RS09465	COG0028	Belongs to the TPP enzyme family
HCM98_RS09475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HCM98_RS09485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HCM98_RS09515	COG2814	Major facilitator Superfamily
HCM98_RS09520	COG3384	dioxygenase
HCM98_RS09530	COG3279	Response regulator of the LytR AlgR family
HCM98_RS09535	COG0427	acetyl-CoA hydrolase
HCM98_RS09570	COG4166	transmembrane transport
HCM98_RS09595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS09615	COG1914	H( )-stimulated, divalent metal cation uptake system
HCM98_RS09630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCM98_RS09635	COG0531	amino acid
HCM98_RS09655	COG1280	lysine exporter protein (LysE YggA)
HCM98_RS09665	COG1309	transcriptional regulator
HCM98_RS09670	COG2390	Transcriptional regulator
HCM98_RS09680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS09685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HCM98_RS09700	COG4846	Membrane protein involved in cytochrome C biogenesis
HCM98_RS09710	COG0006	proline dipeptidase activity
HCM98_RS09725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCM98_RS09750	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS09760	COG2372	response to copper ion
HCM98_RS09760	COG1276	copper resistance
HCM98_RS09765	COG4549	nuclear export factor GLE1
HCM98_RS09775	COG0697	spore germination
HCM98_RS09780	COG0583	DNA-binding transcription factor activity
HCM98_RS09785	COG1959	2 iron, 2 sulfur cluster binding
HCM98_RS09790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HCM98_RS09795	COG0778	Nitroreductase
HCM98_RS09805	COG0628	permease
HCM98_RS09815	COG1231	oxidoreductase activity
HCM98_RS09840	COG1733	regulation of RNA biosynthetic process
HCM98_RS09845	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCM98_RS09850	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS09875	COG0384	phenazine biosynthesis protein PhzF
HCM98_RS09895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS09915	COG1733	regulation of RNA biosynthetic process
HCM98_RS09920	COG1733	regulation of RNA biosynthetic process
HCM98_RS09925	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HCM98_RS09930	COG0673	inositol 2-dehydrogenase activity
HCM98_RS09935	COG2188	Transcriptional regulator
HCM98_RS09940	COG1733	regulation of RNA biosynthetic process
HCM98_RS09945	COG1393	Belongs to the ArsC family
HCM98_RS09975	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS10000	COG0463	Glycosyl transferase, family 2
HCM98_RS10015	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS10035	COG0814	amino acid
HCM98_RS10040	COG0346	lactoylglutathione lyase activity
HCM98_RS10055	COG2814	Major facilitator Superfamily
HCM98_RS10060	COG0656	L-ascorbic acid biosynthetic process
HCM98_RS10080	COG1733	regulation of RNA biosynthetic process
HCM98_RS10085	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCM98_RS10085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HCM98_RS10090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCM98_RS10090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCM98_RS10100	COG0840	transmembrane signaling receptor activity
HCM98_RS10115	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS10135	COG0789	Transcriptional regulator
HCM98_RS10140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCM98_RS10145	COG0604	alcohol dehydrogenase
HCM98_RS10150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCM98_RS10155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HCM98_RS10165	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HCM98_RS10170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HCM98_RS10185	COG2706	6-phosphogluconolactonase activity
HCM98_RS10190	COG3813	Protein conserved in bacteria
HCM98_RS10195	COG1357	PFAM Pentapeptide repeats (8 copies)
HCM98_RS10200	COG0697	spore germination
HCM98_RS10230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCM98_RS10240	COG0789	Transcriptional regulator
HCM98_RS10245	COG1253	flavin adenine dinucleotide binding
HCM98_RS10270	COG0477	Major facilitator Superfamily
HCM98_RS10280	COG0500	methyltransferase
HCM98_RS10310	COG0628	permease
HCM98_RS10325	COG0110	maltose O-acetyltransferase activity
HCM98_RS10330	COG1940	carbohydrate kinase activity
HCM98_RS10335	COG0346	lactoylglutathione lyase activity
HCM98_RS10360	COG2365	Tyrosine phosphatase family
HCM98_RS10370	COG1011	Hydrolase
HCM98_RS10395	COG1131	(ABC) transporter
HCM98_RS10405	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS10425	COG0778	Nitroreductase
HCM98_RS10430	COG1733	regulation of RNA biosynthetic process
HCM98_RS10450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HCM98_RS10480	COG2356	endonuclease I
HCM98_RS10485	COG1288	antiporter activity
HCM98_RS10490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HCM98_RS10505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HCM98_RS10540	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCM98_RS10550	COG2031	fatty acid transporter
HCM98_RS10565	COG1309	transcriptional regulator
HCM98_RS10570	COG2076	Multidrug Resistance protein
HCM98_RS10590	COG1131	(ABC) transporter
HCM98_RS10595	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCM98_RS10605	COG2814	Major facilitator Superfamily
HCM98_RS10610	COG1846	Transcriptional regulator
HCM98_RS10625	COG0477	Major facilitator Superfamily
HCM98_RS10635	COG2843	Capsule synthesis protein
HCM98_RS10640	COG1876	peptidase activity
HCM98_RS10670	COG3409	Peptidoglycan-binding domain 1 protein
HCM98_RS10670	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS10685	COG2207	Transcriptional regulator
HCM98_RS10685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS10690	COG0662	Cupin 2, conserved barrel domain protein
HCM98_RS10710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HCM98_RS10730	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCM98_RS10750	COG0583	DNA-binding transcription factor activity
HCM98_RS10760	COG1139	Iron-sulfur cluster binding protein
HCM98_RS10765	COG1556	Lactate utilization protein
HCM98_RS10770	COG2271	Major facilitator Superfamily
HCM98_RS10775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS10780	COG2808	Putative FMN-binding domain
HCM98_RS10785	COG0456	acetyltransferase
HCM98_RS10790	COG1846	Transcriptional regulator
HCM98_RS10795	COG2364	Membrane
HCM98_RS10805	COG3850	Histidine kinase
HCM98_RS10805	COG5002	protein histidine kinase activity
HCM98_RS10820	COG0577	efflux transmembrane transporter activity
HCM98_RS10840	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HCM98_RS10845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS10855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HCM98_RS10860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS10880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HCM98_RS10935	COG4895	conserved protein (DUF2196)
HCM98_RS10945	COG2814	Major facilitator Superfamily
HCM98_RS10990	COG0346	lactoylglutathione lyase activity
HCM98_RS11005	COG1522	sequence-specific DNA binding
HCM98_RS11015	COG1309	transcriptional regulator
HCM98_RS11020	COG2814	Major facilitator Superfamily
HCM98_RS11030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCM98_RS11030	COG3320	Male sterility
HCM98_RS11050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HCM98_RS11060	COG0640	Transcriptional regulator
HCM98_RS11065	COG0346	lactoylglutathione lyase activity
HCM98_RS11070	COG0798	PFAM Bile acid sodium symporter
HCM98_RS11105	COG0577	efflux transmembrane transporter activity
HCM98_RS11110	COG1136	(ABC) transporter
HCM98_RS11115	COG4641	Protein conserved in bacteria
HCM98_RS11155	COG1575	Belongs to the MenA family. Type 1 subfamily
HCM98_RS11170	COG5609	conserved protein (DUF2294)
HCM98_RS11175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCM98_RS11185	COG0288	reversible hydration of carbon dioxide
HCM98_RS11190	COG0415	Belongs to the DNA photolyase family
HCM98_RS11235	COG0583	DNA-binding transcription factor activity
HCM98_RS11270	COG0583	DNA-binding transcription factor activity
HCM98_RS11285	COG0531	amino acid
HCM98_RS11295	COG0534	Mate efflux family protein
HCM98_RS11300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS11300	COG0723	plastoquinol--plastocyanin reductase activity
HCM98_RS11310	COG2124	cytochrome p450
HCM98_RS11320	COG1115	amino acid carrier protein
HCM98_RS11325	COG2066	Belongs to the glutaminase family
HCM98_RS11330	COG4191	Histidine kinase
HCM98_RS11335	COG0784	Response regulator, receiver
HCM98_RS11340	COG0697	spore germination
HCM98_RS11345	COG0531	amino acid
HCM98_RS11355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCM98_RS11360	COG0531	amino acid
HCM98_RS11365	COG0322	excinuclease ABC activity
HCM98_RS11375	COG1396	sequence-specific DNA binding
HCM98_RS11380	COG0252	asparaginase activity
HCM98_RS11385	COG1027	Aspartate ammonia-lyase
HCM98_RS11395	COG1063	alcohol dehydrogenase
HCM98_RS11415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS11420	COG0574	Belongs to the PEP-utilizing enzyme family
HCM98_RS11420	COG3848	Pyruvate phosphate dikinase
HCM98_RS11435	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HCM98_RS11455	COG3314	Sporulation integral membrane protein YlbJ
HCM98_RS11470	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS11480	COG0640	Transcriptional regulator
HCM98_RS11485	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS11490	COG3142	Participates in the control of copper homeostasis
HCM98_RS11500	COG1414	Transcriptional regulator
HCM98_RS11505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HCM98_RS11510	COG1984	allophanate hydrolase subunit 2
HCM98_RS11550	COG0768	penicillin binding
HCM98_RS11585	COG4335	DNA alkylation repair
HCM98_RS11595	COG0833	amino acid
HCM98_RS11605	COG0730	response to heat
HCM98_RS11645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS11650	COG0697	spore germination
HCM98_RS11665	COG0456	acetyltransferase
HCM98_RS11695	COG1136	(ABC) transporter
HCM98_RS11705	COG3831	ATPase activity
HCM98_RS11705	COG4884	unkown
HCM98_RS11725	COG1846	Transcriptional regulator
HCM98_RS11730	COG0778	Nitroreductase
HCM98_RS11740	COG0714	Associated with various cellular activities
HCM98_RS11765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HCM98_RS11775	COG0753	catalase activity
HCM98_RS11780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCM98_RS11800	COG0714	Associated with various cellular activities
HCM98_RS11820	COG0346	lactoylglutathione lyase activity
HCM98_RS11840	COG3279	Response regulator of the LytR AlgR family
HCM98_RS11850	COG4377	Putative membrane peptidase family (DUF2324)
HCM98_RS11865	COG3655	Transcriptional regulator
HCM98_RS11875	COG1785	Belongs to the alkaline phosphatase family
HCM98_RS11885	COG3239	Fatty acid desaturase
HCM98_RS11890	COG1690	Belongs to the RtcB family
HCM98_RS11900	COG0833	amino acid
HCM98_RS11905	COG1414	Transcriptional regulator
HCM98_RS11910	COG4187	Peptidase family M20/M25/M40
HCM98_RS11915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCM98_RS11930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS11950	COG2329	Antibiotic biosynthesis monooxygenase
HCM98_RS11960	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS11990	COG1070	Carbohydrate kinase
HCM98_RS11995	COG2390	Transcriptional regulator
HCM98_RS12005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCM98_RS12010	COG1172	Belongs to the binding-protein-dependent transport system permease family
HCM98_RS12015	COG1879	ABC-type sugar transport system periplasmic component
HCM98_RS12040	COG1388	LysM domain
HCM98_RS12040	COG3584	3D domain protein
HCM98_RS12065	COG1605	Chorismate mutase
HCM98_RS12065	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HCM98_RS12080	COG0287	Prephenate dehydrogenase
HCM98_RS12095	COG1309	transcriptional regulator
HCM98_RS12100	COG2409	Drug exporters of the RND superfamily
HCM98_RS12100	COG1033	growth of symbiont in host cell
HCM98_RS12110	COG0488	(ABC) transporter
HCM98_RS12115	COG1368	sulfuric ester hydrolase activity
HCM98_RS12120	COG0861	Integral membrane protein TerC family
HCM98_RS12125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCM98_RS12170	COG2318	DinB family
HCM98_RS12175	COG0697	spore germination
HCM98_RS12195	COG2746	aminoglycoside 3-N-acetyltransferase activity
HCM98_RS12240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCM98_RS12245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCM98_RS12250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCM98_RS12260	COG0628	permease
HCM98_RS12310	COG1131	(ABC) transporter
HCM98_RS12335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HCM98_RS12340	COG0436	Aminotransferase
HCM98_RS12390	COG2261	transglycosylase associated protein
HCM98_RS12410	COG2814	Major facilitator Superfamily
HCM98_RS12410	COG0477	Major facilitator Superfamily
HCM98_RS12415	COG4533	DNA binding
HCM98_RS12420	COG0789	Transcriptional regulator
HCM98_RS12425	COG1664	Polymer-forming cytoskeletal
HCM98_RS12435	COG2814	Major facilitator Superfamily
HCM98_RS12475	COG1307	EDD domain protein, DegV family
HCM98_RS12485	COG1164	Oligoendopeptidase f
HCM98_RS12525	COG0745	RESPONSE REGULATOR receiver
HCM98_RS12530	COG5002	protein histidine kinase activity
HCM98_RS12535	COG2936	dipeptidyl-peptidase activity
HCM98_RS12580	COG4948	Mandelate Racemase Muconate Lactonizing
HCM98_RS12590	COG4166	transmembrane transport
HCM98_RS12600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HCM98_RS12615	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS12670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS12675	COG3938	Belongs to the proline racemase family
HCM98_RS12685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HCM98_RS12690	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS12695	COG1115	amino acid carrier protein
HCM98_RS12700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HCM98_RS12715	COG3397	chitin binding
HCM98_RS12745	COG4637	Psort location Cytoplasmic, score
HCM98_RS12770	COG0514	ATP-dependent DNA helicase (RecQ)
HCM98_RS12790	COG3973	AAA domain
HCM98_RS12835	COG0658	competence protein
HCM98_RS12835	COG2333	competence protein COMEC
HCM98_RS12845	COG2315	Protein conserved in bacteria
HCM98_RS12850	COG2226	methyltransferase
HCM98_RS12855	COG2205	protein histidine kinase activity
HCM98_RS12870	COG1819	glycosyl
HCM98_RS12875	COG3397	chitin binding
HCM98_RS12880	COG2153	protein acetylation
HCM98_RS12910	COG0517	IMP dehydrogenase activity
HCM98_RS12910	COG4175	Glycine betaine
HCM98_RS12915	COG4176	ABC-type proline glycine betaine transport system permease component
HCM98_RS12955	COG0572	uridine kinase
HCM98_RS12960	COG0456	acetyltransferase
HCM98_RS12960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCM98_RS12965	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS12975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCM98_RS12980	COG0022	dehydrogenase e1 component
HCM98_RS12985	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCM98_RS12990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCM98_RS13005	COG1959	2 iron, 2 sulfur cluster binding
HCM98_RS13020	COG1349	DNA-binding transcription factor activity
HCM98_RS13040	COG3284	Transcriptional regulator
HCM98_RS13060	COG1473	amidohydrolase
HCM98_RS13070	COG4948	Mandelate Racemase Muconate Lactonizing
HCM98_RS13075	COG3949	Membrane
HCM98_RS13085	COG1309	transcriptional regulator
HCM98_RS13125	COG2959	enzyme of heme biosynthesis
HCM98_RS13140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS13185	COG0697	spore germination
HCM98_RS13195	COG0201	protein transport
HCM98_RS13220	COG3227	Zinc metalloprotease (Elastase)
HCM98_RS13225	COG1523	belongs to the glycosyl hydrolase 13 family
HCM98_RS13250	COG1011	Hydrolase
HCM98_RS13275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS13310	COG0322	excinuclease ABC activity
HCM98_RS13350	COG4667	esterase of the alpha-beta hydrolase superfamily
HCM98_RS13370	COG3878	Protein conserved in bacteria
HCM98_RS13395	COG0592	DNA-directed DNA polymerase activity
HCM98_RS13415	COG2223	nitrite transmembrane transporter activity
HCM98_RS13425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCM98_RS13440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCM98_RS13450	COG0697	spore germination
HCM98_RS13455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS13470	COG0584	glycerophosphoryl diester phosphodiesterase
HCM98_RS13495	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS13530	COG0768	penicillin binding
HCM98_RS13535	COG0671	phosphoesterase, PA-phosphatase related
HCM98_RS13540	COG0604	alcohol dehydrogenase
HCM98_RS13545	COG5002	protein histidine kinase activity
HCM98_RS13550	COG0745	RESPONSE REGULATOR receiver
HCM98_RS13560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCM98_RS13570	COG2205	protein histidine kinase activity
HCM98_RS13635	COG0109	protoheme IX farnesyltransferase activity
HCM98_RS13685	COG0723	plastoquinol--plastocyanin reductase activity
HCM98_RS13685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HCM98_RS13725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCM98_RS13750	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS13765	COG1794	racemase activity, acting on amino acids and derivatives
HCM98_RS13770	COG1819	glycosyl
HCM98_RS13780	COG5002	protein histidine kinase activity
HCM98_RS13785	COG0561	phosphatase activity
HCM98_RS13820	COG2124	cytochrome p450
HCM98_RS13875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HCM98_RS13885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS13890	COG0460	homoserine dehydrogenase
HCM98_RS13910	COG0577	efflux transmembrane transporter activity
HCM98_RS13915	COG1136	(ABC) transporter
HCM98_RS13930	COG0488	(ABC) transporter
HCM98_RS13940	COG2205	protein histidine kinase activity
HCM98_RS13945	COG0745	RESPONSE REGULATOR receiver
HCM98_RS13955	COG3773	Cell wall hydrolase
HCM98_RS13960	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HCM98_RS13970	COG3386	PFAM SMP-30 Gluconolaconase
HCM98_RS13980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCM98_RS13990	COG2323	membrane
HCM98_RS14010	COG2368	4-hydroxyphenylacetate
HCM98_RS14020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS14040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCM98_RS14050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCM98_RS14065	COG2226	methyltransferase
HCM98_RS14075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCM98_RS14105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCM98_RS14120	COG3227	Zinc metalloprotease (Elastase)
HCM98_RS14140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HCM98_RS14165	COG1686	Belongs to the peptidase S11 family
HCM98_RS14170	COG2318	DinB family
HCM98_RS14175	COG0596	Alpha beta hydrolase
HCM98_RS14180	COG0572	uridine kinase
HCM98_RS14195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCM98_RS14200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HCM98_RS14205	COG1024	Enoyl-CoA hydratase
HCM98_RS14210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HCM98_RS14215	COG0511	ligase activity, forming carbon-carbon bonds
HCM98_RS14220	COG0439	Biotin carboxylase
HCM98_RS14225	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS14240	COG1309	transcriptional regulator
HCM98_RS14250	COG1131	(ABC) transporter
HCM98_RS14285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCM98_RS14290	COG1442	glycosyl transferase family 8
HCM98_RS14295	COG1088	dTDP-glucose 4,6-dehydratase activity
HCM98_RS14305	COG0457	Tetratricopeptide repeat
HCM98_RS14340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS14345	COG5001	Diguanylate cyclase
HCM98_RS14345	COG3300	MHYT domain
HCM98_RS14380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS14395	COG2755	lipolytic protein G-D-S-L family
HCM98_RS14395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HCM98_RS14400	COG3773	Cell wall hydrolase
HCM98_RS14415	COG3718	enzyme involved in inositol metabolism
HCM98_RS14445	COG0673	inositol 2-dehydrogenase activity
HCM98_RS14450	COG2814	Major facilitator Superfamily
HCM98_RS14455	COG1609	Transcriptional regulator
HCM98_RS14465	COG2367	Beta-lactamase
HCM98_RS14470	COG0768	penicillin binding
HCM98_RS14475	COG0768	penicillin binding
HCM98_RS14485	COG1595	DNA-templated transcription, initiation
HCM98_RS14505	COG1686	Belongs to the peptidase S11 family
HCM98_RS14520	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCM98_RS14545	COG1846	Transcriptional regulator
HCM98_RS14550	COG3961	Belongs to the TPP enzyme family
HCM98_RS14560	COG0500	methyltransferase
HCM98_RS14560	COG3615	Tellurite resistance protein tehB
HCM98_RS14565	COG0577	efflux transmembrane transporter activity
HCM98_RS14565	COG1136	(ABC) transporter
HCM98_RS14580	COG1309	transcriptional regulator
HCM98_RS14605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS14630	COG1846	Transcriptional regulator
HCM98_RS14650	COG2971	BadF BadG BcrA BcrD
HCM98_RS14675	COG1649	PFAM Uncharacterised BCR, COG1649
HCM98_RS14700	COG1595	DNA-templated transcription, initiation
HCM98_RS14705	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HCM98_RS14715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCM98_RS14745	COG1396	sequence-specific DNA binding
HCM98_RS14765	COG1132	(ABC) transporter
HCM98_RS14770	COG1132	(ABC) transporter
HCM98_RS14805	COG0583	DNA-binding transcription factor activity
HCM98_RS14815	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS14820	COG0010	Belongs to the arginase family
HCM98_RS15025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCM98_RS15065	COG2002	toxin-antitoxin pair type II binding
HCM98_RS15110	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS15150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCM98_RS15150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCM98_RS15275	COG1278	Cold shock
HCM98_RS15285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS15295	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HCM98_RS15325	COG1247	-acetyltransferase
HCM98_RS15360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS15370	COG1846	Transcriptional regulator
HCM98_RS15415	COG0028	Belongs to the TPP enzyme family
HCM98_RS15430	COG2814	Major facilitator Superfamily
HCM98_RS15435	COG0596	Alpha beta hydrolase
HCM98_RS15445	COG1136	(ABC) transporter
HCM98_RS15455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCM98_RS15460	COG1187	pseudouridine synthase activity
HCM98_RS15465	COG2329	Antibiotic biosynthesis monooxygenase
HCM98_RS15485	COG1115	amino acid carrier protein
HCM98_RS15495	COG2318	DinB family
HCM98_RS15505	COG0776	regulation of translation
HCM98_RS15520	COG2814	Major facilitator Superfamily
HCM98_RS15525	COG3251	PFAM MbtH domain protein
HCM98_RS15530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCM98_RS15535	COG3433	isochorismatase activity
HCM98_RS15535	COG1535	isochorismatase
HCM98_RS15540	COG1021	2,3-dihydroxybenzoate-AMP ligase
HCM98_RS15545	COG1169	isochorismate synthase
HCM98_RS15550	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS15555	COG2223	nitrite transmembrane transporter activity
HCM98_RS15580	COG0420	3'-5' exonuclease activity
HCM98_RS15595	COG1024	Enoyl-CoA hydratase
HCM98_RS15600	COG1280	lysine exporter protein (LysE YggA)
HCM98_RS15610	COG2084	Dehydrogenase
HCM98_RS15615	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS15620	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HCM98_RS15625	COG2079	MmgE PrpD family protein
HCM98_RS15630	COG0372	Belongs to the citrate synthase family
HCM98_RS15635	COG4841	protein insertion into membrane
HCM98_RS15640	COG2814	Major facilitator Superfamily
HCM98_RS15650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCM98_RS15650	COG4499	WXG100 protein secretion system (Wss), protein YukC
HCM98_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS15710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HCM98_RS15740	COG1595	DNA-templated transcription, initiation
HCM98_RS15770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCM98_RS15775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCM98_RS15780	COG0671	phosphoesterase, PA-phosphatase related
HCM98_RS15790	COG4991	sh3 domain protein
HCM98_RS15790	COG3064	Membrane
HCM98_RS15790	COG0515	serine threonine protein kinase
HCM98_RS15825	COG1509	lysine 2,3-aminomutase activity
HCM98_RS15830	COG3829	transcription factor binding
HCM98_RS15835	COG0456	acetyltransferase
HCM98_RS15840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCM98_RS15845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HCM98_RS15850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HCM98_RS15855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCM98_RS15870	COG5506	Protein of unknown function (DUF1694)
HCM98_RS15875	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS15880	COG1253	flavin adenine dinucleotide binding
HCM98_RS15915	COG1174	glycine betaine transport
HCM98_RS15920	COG1125	glycine betaine transport
HCM98_RS15920	COG0517	IMP dehydrogenase activity
HCM98_RS15975	COG1064	alcohol dehydrogenase
HCM98_RS15990	COG2197	response regulator
HCM98_RS15995	COG4585	Histidine kinase
HCM98_RS15995	COG2203	Gaf domain
HCM98_RS16000	COG0668	transmembrane transport
HCM98_RS16005	COG0071	Belongs to the small heat shock protein (HSP20) family
HCM98_RS16010	COG1335	isochorismatase
HCM98_RS16030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCM98_RS16035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS16050	COG0367	asparagine synthase
HCM98_RS16055	COG0071	Belongs to the small heat shock protein (HSP20) family
HCM98_RS16060	COG1999	signal sequence binding
HCM98_RS16065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HCM98_RS16070	COG1307	EDD domain protein, DegV family
HCM98_RS16080	COG0805	protein transport
HCM98_RS16090	COG1272	protein, Hemolysin III
HCM98_RS16095	COG0204	Acyl-transferase
HCM98_RS16105	COG0768	penicillin binding
HCM98_RS16120	COG3250	beta-galactosidase activity
HCM98_RS16145	COG0546	phosphoglycolate phosphatase activity
HCM98_RS16155	COG4473	ABC transporter
HCM98_RS16160	COG1131	(ABC) transporter
HCM98_RS16170	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HCM98_RS16175	COG0456	acetyltransferase
HCM98_RS16215	COG2610	gluconate transmembrane transporter activity
HCM98_RS16240	COG0733	neurotransmitter:sodium symporter activity
HCM98_RS16345	COG1674	ftsk spoiiie
HCM98_RS16365	COG0017	Asparaginyl-tRNA synthetase
HCM98_RS16420	COG0018	arginyl-trna synthetase
HCM98_RS16425	COG2521	methyltransferase
HCM98_RS16425	COG2136	Putative SAM-dependent methyltransferase
HCM98_RS16440	COG1413	lyase activity
HCM98_RS16465	COG0488	(ABC) transporter
HCM98_RS16470	COG1418	mRNA catabolic process
HCM98_RS16505	COG2359	stage V sporulation protein S
HCM98_RS16535	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HCM98_RS16540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HCM98_RS16545	COG2146	nitrite reductase [NAD(P)H] activity
HCM98_RS16550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HCM98_RS16550	COG1587	Uroporphyrinogen-III synthase
HCM98_RS16560	COG1648	precorrin-2 dehydrogenase activity
HCM98_RS16580	COG2223	nitrite transmembrane transporter activity
HCM98_RS16590	COG0314	molybdopterin synthase activity
HCM98_RS16595	COG0303	'Molybdopterin
HCM98_RS16600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCM98_RS16605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCM98_RS16610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HCM98_RS16615	COG2181	nitrate reductase activity
HCM98_RS16620	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HCM98_RS16625	COG1140	nitrate reductase beta subunit
HCM98_RS16630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HCM98_RS16635	COG0714	Associated with various cellular activities
HCM98_RS16640	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HCM98_RS16645	COG1305	Transglutaminase-like
HCM98_RS16650	COG0386	Belongs to the glutathione peroxidase family
HCM98_RS16660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCM98_RS16660	COG0426	domain, Protein
HCM98_RS16680	COG1595	DNA-templated transcription, initiation
HCM98_RS16685	COG0604	alcohol dehydrogenase
HCM98_RS16695	COG0346	lactoylglutathione lyase activity
HCM98_RS16715	COG2226	methyltransferase
HCM98_RS16740	COG3874	Sporulation protein YtfJ
HCM98_RS16765	COG4974	Belongs to the 'phage' integrase family
HCM98_RS16785	COG0456	acetyltransferase
HCM98_RS16815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS16820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS16825	COG1819	glycosyl
HCM98_RS16840	COG4106	trans-aconitate 2-methyltransferase activity
HCM98_RS16845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HCM98_RS16855	COG0561	phosphatase activity
HCM98_RS16885	COG3971	2-oxopent-4-enoate hydratase activity
HCM98_RS16895	COG0251	oxidation-reduction process
HCM98_RS16910	COG0196	riboflavin kinase activity
HCM98_RS16920	COG2368	4-hydroxyphenylacetate
HCM98_RS16935	COG2211	Major facilitator Superfamily
HCM98_RS16940	COG0154	amidase activity
HCM98_RS16950	COG1876	peptidase activity
HCM98_RS16960	COG0860	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS16980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCM98_RS16985	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS17000	COG1253	flavin adenine dinucleotide binding
HCM98_RS17005	COG2839	Protein conserved in bacteria
HCM98_RS17010	COG0702	epimerase
HCM98_RS17025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCM98_RS17035	COG1607	acyl-coa hydrolase
HCM98_RS17040	COG3689	TIGRFAM TIGR03943 family protein
HCM98_RS17045	COG0701	Predicted permease
HCM98_RS17055	COG2244	polysaccharide biosynthetic process
HCM98_RS17060	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS17065	COG1051	belongs to the nudix hydrolase family
HCM98_RS17070	COG5337	Spore coat protein CotH
HCM98_RS17105	COG4166	transmembrane transport
HCM98_RS17115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCM98_RS17125	COG0702	epimerase
HCM98_RS17135	COG3443	Belongs to the bacterial solute-binding protein 9 family
HCM98_RS17135	COG0803	Belongs to the bacterial solute-binding protein 9 family
HCM98_RS17140	COG0456	acetyltransferase
HCM98_RS17145	COG0523	cobalamin synthesis protein
HCM98_RS17150	COG4989	oxidoreductase activity
HCM98_RS17155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS17160	COG1231	oxidoreductase activity
HCM98_RS17170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HCM98_RS17185	COG0783	Belongs to the Dps family
HCM98_RS17190	COG3949	Membrane
HCM98_RS17230	COG2814	Major facilitator Superfamily
HCM98_RS17235	COG0667	Aldo Keto reductase
HCM98_RS17240	COG0640	Transcriptional regulator
HCM98_RS17245	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HCM98_RS17250	COG1404	Belongs to the peptidase S8 family
HCM98_RS17255	COG2002	toxin-antitoxin pair type II binding
HCM98_RS17260	COG0577	efflux transmembrane transporter activity
HCM98_RS17295	COG1752	Esterase of the alpha-beta hydrolase superfamily
HCM98_RS17305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS17310	COG1279	arginine transmembrane transporter activity
HCM98_RS17315	COG2814	Major facilitator Superfamily
HCM98_RS17325	COG1082	Xylose isomerase domain protein TIM barrel
HCM98_RS17335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCM98_RS17355	COG1247	-acetyltransferase
HCM98_RS17360	COG1285	pathogenesis
HCM98_RS17375	COG5002	protein histidine kinase activity
HCM98_RS17380	COG0745	RESPONSE REGULATOR receiver
HCM98_RS17390	COG1316	TRANSCRIPTIONal
HCM98_RS17415	COG0460	homoserine dehydrogenase
HCM98_RS17440	COG4122	O-methyltransferase activity
HCM98_RS17445	COG0300	oxidoreductase activity
HCM98_RS17455	COG5002	protein histidine kinase activity
HCM98_RS17460	COG0745	RESPONSE REGULATOR receiver
HCM98_RS17465	COG1132	(ABC) transporter
HCM98_RS17475	COG0791	NLP P60 protein
HCM98_RS17475	COG1388	LysM domain
HCM98_RS17490	COG1686	Belongs to the peptidase S11 family
HCM98_RS17520	COG1216	Glycosyl transferase, family 2
HCM98_RS17530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HCM98_RS17535	COG4988	ABC transporter
HCM98_RS17540	COG1294	oxidase, subunit
HCM98_RS17545	COG1271	oxidase subunit
HCM98_RS17565	COG1942	4-Oxalocrotonate Tautomerase
HCM98_RS17575	COG0583	DNA-binding transcription factor activity
HCM98_RS17595	COG0411	ABC transporter
HCM98_RS17605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS17610	COG2030	dehydratase
HCM98_RS17615	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS17655	COG1191	sigma factor activity
HCM98_RS17665	COG1280	lysine exporter protein (LysE YggA)
HCM98_RS17685	COG3152	Membrane
HCM98_RS17715	COG1151	hydroxylamine reductase activity
HCM98_RS17725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS17765	COG2072	flavoprotein involved in K transport
HCM98_RS17805	COG1113	amino acid transport
HCM98_RS17810	COG2814	Major facilitator Superfamily
HCM98_RS17840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCM98_RS17845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCM98_RS17860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS17865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS17870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS17875	COG3739	integral membrane protein
HCM98_RS17910	COG0583	DNA-binding transcription factor activity
HCM98_RS17930	COG1193	negative regulation of DNA recombination
HCM98_RS17945	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HCM98_RS17950	COG1164	Oligoendopeptidase f
HCM98_RS17955	COG0789	Transcriptional regulator
HCM98_RS17955	COG4978	Transcriptional regulator
HCM98_RS17970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HCM98_RS18000	COG0584	glycerophosphoryl diester phosphodiesterase
HCM98_RS18045	COG0640	Transcriptional regulator
HCM98_RS18050	COG0604	alcohol dehydrogenase
HCM98_RS18060	COG0457	Tetratricopeptide repeat
HCM98_RS18070	COG2808	Putative FMN-binding domain
HCM98_RS18075	COG0456	acetyltransferase
HCM98_RS18075	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCM98_RS18085	COG0385	Bile acid
HCM98_RS18090	COG0277	FAD linked oxidase domain protein
HCM98_RS18110	COG0825	malonyl-CoA metabolic process
HCM98_RS18125	COG1309	transcriptional regulator
HCM98_RS18155	COG3852	Histidine kinase
HCM98_RS18165	COG1285	pathogenesis
HCM98_RS18180	COG2514	catechol 2,3-dioxygenase activity
HCM98_RS18185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS18190	COG1126	abc transporter atp-binding protein
HCM98_RS18210	COG2720	vancomycin resistance protein
HCM98_RS18250	COG0716	FMN binding
HCM98_RS18280	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS18290	COG0165	Argininosuccinate lyase
HCM98_RS18305	COG4145	pantothenate transmembrane transporter activity
HCM98_RS18315	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS18330	COG1657	PFAM Prenyltransferase squalene oxidase
HCM98_RS18335	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HCM98_RS18340	COG2962	Rard protein
HCM98_RS18345	COG3326	Membrane
HCM98_RS18360	COG0489	protein tyrosine kinase activity
HCM98_RS18370	COG0314	molybdopterin synthase activity
HCM98_RS18375	COG0303	'Molybdopterin
HCM98_RS18380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCM98_RS18385	COG2116	formate transmembrane transporter activity
HCM98_RS18410	COG5609	conserved protein (DUF2294)
HCM98_RS18415	COG2427	Protein of unknown function (DUF1641)
HCM98_RS18545	COG0740	serine-type endopeptidase activity
HCM98_RS18555	COG4626	Terminase
HCM98_RS18555	COG1802	Transcriptional regulator
HCM98_RS18590	COG1674	ftsk spoiiie
HCM98_RS18590	COG4980	gas vesicle protein
HCM98_RS18595	COG0582	viral genome integration into host DNA
HCM98_RS18610	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS18655	COG1484	DNA-dependent DNA replication
HCM98_RS18720	COG0697	spore germination
HCM98_RS18765	COG2226	methyltransferase
HCM98_RS18770	COG4166	transmembrane transport
HCM98_RS18775	COG4166	transmembrane transport
HCM98_RS18780	COG4166	transmembrane transport
HCM98_RS18790	COG1316	TRANSCRIPTIONal
HCM98_RS18800	COG1595	DNA-templated transcription, initiation
HCM98_RS18820	COG1131	(ABC) transporter
HCM98_RS18840	COG0673	inositol 2-dehydrogenase activity
HCM98_RS18845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCM98_RS18850	COG0187	DNA topoisomerase II activity
HCM98_RS18855	COG1832	CoA-binding protein
HCM98_RS18860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCM98_RS18865	COG0745	RESPONSE REGULATOR receiver
HCM98_RS18885	COG4841	protein insertion into membrane
HCM98_RS18890	COG0824	Thioesterase
HCM98_RS18915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCM98_RS18925	COG2274	protein secretion by the type I secretion system
HCM98_RS18930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HCM98_RS18960	COG2211	Major facilitator Superfamily
HCM98_RS18975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HCM98_RS18990	COG0183	Belongs to the thiolase family
HCM98_RS18995	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS19000	COG1268	BioY protein
HCM98_RS19005	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS19015	COG1131	(ABC) transporter
HCM98_RS19020	COG1396	sequence-specific DNA binding
HCM98_RS19065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS19075	COG5002	protein histidine kinase activity
HCM98_RS19080	COG0400	carboxylic ester hydrolase activity
HCM98_RS19085	COG0346	lactoylglutathione lyase activity
HCM98_RS19090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HCM98_RS19100	COG0069	glutamate synthase activity
HCM98_RS19105	COG1902	pentaerythritol trinitrate reductase activity
HCM98_RS19125	COG0010	Belongs to the arginase family
HCM98_RS19175	COG4846	Membrane protein involved in cytochrome C biogenesis
HCM98_RS19180	COG0785	Cytochrome C biogenesis protein
HCM98_RS19190	COG1473	amidohydrolase
HCM98_RS19200	COG1131	(ABC) transporter
HCM98_RS19210	COG0583	DNA-binding transcription factor activity
HCM98_RS19220	COG1346	cytolysis
HCM98_RS19235	COG0730	response to heat
HCM98_RS19245	COG5632	N-Acetylmuramoyl-L-alanine amidase
HCM98_RS19245	COG3409	Peptidoglycan-binding domain 1 protein
HCM98_RS19265	COG1132	(ABC) transporter
HCM98_RS19270	COG1132	(ABC) transporter
HCM98_RS19295	COG3639	organic phosphonate transmembrane transporter activity
HCM98_RS19305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS19310	COG0737	Belongs to the 5'-nucleotidase family
HCM98_RS19320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HCM98_RS19340	COG1695	Transcriptional regulator
HCM98_RS19345	COG1132	(ABC) transporter
HCM98_RS19380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HCM98_RS19385	COG0110	maltose O-acetyltransferase activity
HCM98_RS19390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HCM98_RS19415	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS19420	COG1442	glycosyl transferase family 8
HCM98_RS19420	COG1216	Glycosyl transferase, family 2
HCM98_RS19430	COG1442	glycosyl transferase family 8
HCM98_RS19445	COG0463	Glycosyl transferase, family 2
HCM98_RS19445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HCM98_RS19450	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS19455	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS19460	COG1086	Polysaccharide biosynthesis protein
HCM98_RS19465	COG0489	protein tyrosine kinase activity
HCM98_RS19470	COG3944	biosynthesis protein
HCM98_RS19475	COG0174	glutamine synthetase
HCM98_RS19480	COG0789	Transcriptional regulator
HCM98_RS19485	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HCM98_RS19490	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HCM98_RS19495	COG2860	membrane
HCM98_RS19500	COG0464	growth
HCM98_RS19530	COG3584	3D domain protein
HCM98_RS19530	COG1388	LysM domain
HCM98_RS19535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCM98_RS19535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HCM98_RS19535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCM98_RS19540	COG1105	Belongs to the carbohydrate kinase PfkB family
HCM98_RS19545	COG1349	DNA-binding transcription factor activity
HCM98_RS19550	COG1979	alcohol dehydrogenase
HCM98_RS19555	COG2322	membrane
HCM98_RS19565	COG1113	amino acid transport
HCM98_RS19575	COG1408	metallophosphoesterase
HCM98_RS19580	COG2116	formate transmembrane transporter activity
HCM98_RS19595	COG2217	Heavy metal translocating P-type atpase
HCM98_RS19600	COG2608	mercury ion transmembrane transporter activity
HCM98_RS19605	COG1937	Protein conserved in bacteria
HCM98_RS19615	COG2819	hydrolase of the alpha beta superfamily
HCM98_RS19620	COG1120	ATPase activity
HCM98_RS19625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS19630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS19635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS19640	COG0708	Exodeoxyribonuclease III
HCM98_RS19645	COG2169	Transcriptional regulator
HCM98_RS19650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HCM98_RS19655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HCM98_RS19665	COG2364	Membrane
HCM98_RS19680	COG2267	carboxylic ester hydrolase activity
HCM98_RS19685	COG0346	lactoylglutathione lyase activity
HCM98_RS19700	COG0384	phenazine biosynthesis protein PhzF
HCM98_RS19710	COG1346	cytolysis
HCM98_RS19715	COG1380	Effector of murein hydrolase LrgA
HCM98_RS19720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HCM98_RS19730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HCM98_RS19740	COG2188	Transcriptional regulator
HCM98_RS19745	COG2723	6-phospho-beta-galactosidase activity
HCM98_RS19755	COG1404	Belongs to the peptidase S8 family
HCM98_RS19760	COG3773	Cell wall hydrolase
HCM98_RS19770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HCM98_RS19780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HCM98_RS19805	COG1131	(ABC) transporter
HCM98_RS19825	COG4550	Control of competence regulator ComK, YlbF/YmcA
HCM98_RS19835	COG1013	pyruvate-flavodoxin oxidoreductase activity
HCM98_RS19840	COG0674	pyruvate-flavodoxin oxidoreductase activity
HCM98_RS19840	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HCM98_RS19850	COG2359	stage V sporulation protein S
HCM98_RS19855	COG1692	metallophosphoesterase
HCM98_RS19885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HCM98_RS19890	COG1426	Protein conserved in bacteria
HCM98_RS19905	COG0300	oxidoreductase activity
HCM98_RS19910	COG0612	Peptidase, M16
HCM98_RS19915	COG0612	Peptidase, M16
HCM98_RS19925	COG1079	Belongs to the binding-protein-dependent transport system permease family
HCM98_RS19930	COG4603	Belongs to the binding-protein-dependent transport system permease family
HCM98_RS19935	COG3845	ABC transporter
HCM98_RS19940	COG1744	ABC transporter substrate-binding protein PnrA-like
HCM98_RS19945	COG2188	Transcriptional regulator
HCM98_RS19950	COG1674	ftsk spoiiie
HCM98_RS19960	COG0740	serine-type endopeptidase activity
HCM98_RS19965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCM98_RS19975	COG0527	aspartate kinase activity
HCM98_RS19980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HCM98_RS19985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCM98_RS19990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCM98_RS19995	COG1873	PFAM PRC-barrel domain
HCM98_RS20000	COG0612	Peptidase, M16
HCM98_RS20005	COG0726	polysaccharide deacetylase
HCM98_RS20020	COG0196	riboflavin kinase activity
HCM98_RS20035	COG1550	Protein conserved in bacteria
HCM98_RS20045	COG1358	cellular component organization or biogenesis
HCM98_RS20050	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HCM98_RS20055	COG0195	Participates in both transcription termination and antitermination
HCM98_RS20075	COG0750	zinc metalloprotease
HCM98_RS20085	COG4589	Belongs to the CDS family
HCM98_RS20100	COG0528	UMP kinase activity
HCM98_RS20130	COG4974	Belongs to the 'phage' integrase family
HCM98_RS20140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCM98_RS20160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HCM98_RS20200	COG1837	Belongs to the UPF0109 family
HCM98_RS20210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HCM98_RS20220	COG0552	protein localization to endoplasmic reticulum
HCM98_RS20225	COG1196	nuclear chromosome segregation
HCM98_RS20235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HCM98_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS20245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HCM98_RS20260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HCM98_RS20265	COG1461	Dihydroxyacetone kinase
HCM98_RS20270	COG1302	Protein conserved in bacteria
HCM98_RS20285	COG1564	THIamine pyrophosphokinase
HCM98_RS20290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HCM98_RS20300	COG0515	serine threonine protein kinase
HCM98_RS20300	COG2815	serine threonine protein kinase
HCM98_RS20305	COG0631	protein serine/threonine phosphatase activity
HCM98_RS20315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HCM98_RS20315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HCM98_RS20325	COG0242	peptide deformylase activity
HCM98_RS20330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HCM98_RS20335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HCM98_RS20355	COG1561	YicC-like family, N-terminal region
HCM98_RS20360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HCM98_RS20375	COG0006	proline dipeptidase activity
HCM98_RS20395	COG3069	C4-dicarboxylate transmembrane transporter activity
HCM98_RS20405	COG1011	Hydrolase
HCM98_RS20460	COG0564	pseudouridine synthase activity
HCM98_RS20480	COG3599	regulation of cell shape
HCM98_RS20485	COG2302	S4 RNA-binding domain
HCM98_RS20490	COG0762	integral membrane protein
HCM98_RS20500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HCM98_RS20510	COG1873	PFAM PRC-barrel domain
HCM98_RS20515	COG1191	sigma factor activity
HCM98_RS20520	COG1191	sigma factor activity
HCM98_RS20530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HCM98_RS20535	COG0849	cell division
HCM98_RS20540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HCM98_RS20555	COG0772	Belongs to the SEDS family
HCM98_RS20570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HCM98_RS20575	COG0768	penicillin binding
HCM98_RS20580	COG0768	penicillin binding
HCM98_RS20585	COG4839	cell division protein FtsL
HCM98_RS20600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HCM98_RS20615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HCM98_RS20620	COG1399	metal-binding, possibly nucleic acid-binding protein
HCM98_RS20745	COG4626	Terminase
HCM98_RS20745	COG1802	Transcriptional regulator
HCM98_RS20795	COG0582	viral genome integration into host DNA
HCM98_RS20810	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS20885	COG2002	toxin-antitoxin pair type II binding
HCM98_RS20895	COG1484	DNA-dependent DNA replication
HCM98_RS20925	COG1396	sequence-specific DNA binding
HCM98_RS20940	COG1396	sequence-specific DNA binding
HCM98_RS20965	COG0582	viral genome integration into host DNA
HCM98_RS20975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HCM98_RS20985	COG3314	Sporulation integral membrane protein YlbJ
HCM98_RS20995	COG0742	ribosomal rna small subunit methyltransferase
HCM98_RS21010	COG3679	Belongs to the UPF0342 family
HCM98_RS21015	COG0406	alpha-ribazole phosphatase activity
HCM98_RS21030	COG2340	Cysteine-rich secretory protein family
HCM98_RS21040	COG3336	cytochrome c oxidase
HCM98_RS21055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HCM98_RS21075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HCM98_RS21080	COG0772	Belongs to the SEDS family
HCM98_RS21090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HCM98_RS21095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HCM98_RS21105	COG4896	Protein conserved in bacteria
HCM98_RS21120	COG1217	gtp-binding protein TYPA
HCM98_RS21130	COG0483	inositol monophosphate 1-phosphatase activity
HCM98_RS21150	COG1982	Orn Lys Arg decarboxylase major
HCM98_RS21200	COG0022	dehydrogenase e1 component
HCM98_RS21205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCM98_RS21215	COG0242	peptide deformylase activity
HCM98_RS21220	COG0561	phosphatase activity
HCM98_RS21230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HCM98_RS21235	COG0569	domain protein
HCM98_RS21255	COG0583	DNA-binding transcription factor activity
HCM98_RS21260	COG0517	IMP dehydrogenase activity
HCM98_RS21270	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HCM98_RS21280	COG4703	Protein of unknown function (DUF1797)
HCM98_RS21295	COG2200	EAL domain
HCM98_RS21300	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS21305	COG1408	metallophosphoesterase
HCM98_RS21315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HCM98_RS21350	COG2814	Major facilitator Superfamily
HCM98_RS21370	COG3209	COG3209 Rhs family protein
HCM98_RS21380	COG2205	protein histidine kinase activity
HCM98_RS21390	COG0436	Aminotransferase
HCM98_RS21395	COG1609	Transcriptional regulator
HCM98_RS21400	COG3833	ABC-type maltose transport systems, permease component
HCM98_RS21405	COG1175	transmembrane transport
HCM98_RS21410	COG2182	Extracellular solute-binding protein
HCM98_RS21420	COG0366	Alpha amylase catalytic
HCM98_RS21425	COG3842	ATPase activity
HCM98_RS21465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HCM98_RS21470	COG0183	Belongs to the thiolase family
HCM98_RS21500	COG1695	Transcriptional regulator
HCM98_RS21505	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS21525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HCM98_RS21530	COG0436	Aminotransferase
HCM98_RS21565	COG2084	Dehydrogenase
HCM98_RS21570	COG2199	diguanylate cyclase activity
HCM98_RS21575	COG0778	Nitroreductase
HCM98_RS21600	COG1263	PTS System
HCM98_RS21600	COG2190	(PTS) system
HCM98_RS21600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HCM98_RS21605	COG3711	transcriptional antiterminator
HCM98_RS21615	COG2188	Transcriptional regulator
HCM98_RS21625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HCM98_RS21650	COG1547	Domain of unknown function (DUF309)
HCM98_RS21655	COG0456	acetyltransferase
HCM98_RS21660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HCM98_RS21665	COG4086	secreted protein
HCM98_RS21670	COG0561	phosphatase activity
HCM98_RS21675	COG0697	spore germination
HCM98_RS21690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS21715	COG0733	neurotransmitter:sodium symporter activity
HCM98_RS21735	COG1686	Belongs to the peptidase S11 family
HCM98_RS21740	COG1725	Transcriptional regulator
HCM98_RS21745	COG1131	(ABC) transporter
HCM98_RS21765	COG1846	Transcriptional regulator
HCM98_RS21780	COG0598	Magnesium transport protein CorA
HCM98_RS21805	COG4974	Belongs to the 'phage' integrase family
HCM98_RS21815	COG0735	belongs to the Fur family
HCM98_RS21820	COG1300	Membrane
HCM98_RS21840	COG0667	Aldo Keto reductase
HCM98_RS21845	COG0656	L-ascorbic acid biosynthetic process
HCM98_RS21850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HCM98_RS21850	COG0456	acetyltransferase
HCM98_RS21860	COG4085	toxin activity
HCM98_RS21860	COG1525	nuclease
HCM98_RS21860	COG0737	Belongs to the 5'-nucleotidase family
HCM98_RS21870	COG0596	Alpha beta hydrolase
HCM98_RS21875	COG2056	Na+-H+ antiporter family
HCM98_RS21880	COG1609	Transcriptional regulator
HCM98_RS21885	COG0456	acetyltransferase
HCM98_RS21890	COG1073	alpha beta
HCM98_RS21905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCM98_RS21905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HCM98_RS21910	COG0307	riboflavin synthase, alpha
HCM98_RS21935	COG4106	trans-aconitate 2-methyltransferase activity
HCM98_RS21940	COG2226	methyltransferase
HCM98_RS21940	COG1073	alpha beta
HCM98_RS21955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HCM98_RS21965	COG1757	Na H antiporter
HCM98_RS21970	COG0737	Belongs to the 5'-nucleotidase family
HCM98_RS21980	COG1522	sequence-specific DNA binding
HCM98_RS22010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HCM98_RS22035	COG0300	oxidoreductase activity
HCM98_RS22040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS22045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCM98_RS22050	COG1760	l-serine dehydratase
HCM98_RS22055	COG1760	l-serine dehydratase
HCM98_RS22085	COG2195	Cleaves the N-terminal amino acid of tripeptides
HCM98_RS22090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS22105	COG1376	ErfK ybiS ycfS ynhG family protein
HCM98_RS22110	COG4129	membrane
HCM98_RS22115	COG1126	abc transporter atp-binding protein
HCM98_RS22120	COG0765	amino acid transport
HCM98_RS22125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HCM98_RS22145	COG2323	membrane
HCM98_RS22150	COG0772	Belongs to the SEDS family
HCM98_RS22155	COG0508	dehydrogenase complex catalyzes the overall conversion of
HCM98_RS22160	COG0022	dehydrogenase e1 component
HCM98_RS22165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HCM98_RS22170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HCM98_RS22185	COG0280	phosphate acetyltransferase
HCM98_RS22190	COG3829	transcription factor binding
HCM98_RS22190	COG3290	protein histidine kinase activity
HCM98_RS22200	COG0584	glycerophosphoryl diester phosphodiesterase
HCM98_RS22205	COG3093	addiction module antidote protein HigA
HCM98_RS22215	COG0745	RESPONSE REGULATOR receiver
HCM98_RS22220	COG0750	zinc metalloprotease
HCM98_RS22225	COG0497	DNA recombination
HCM98_RS22235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HCM98_RS22245	COG0142	geranyltranstransferase activity
HCM98_RS22270	COG1302	Protein conserved in bacteria
HCM98_RS22275	COG0439	Biotin carboxylase
HCM98_RS22280	COG0511	ligase activity, forming carbon-carbon bonds
HCM98_RS22325	COG3854	ATPases associated with a variety of cellular activities
HCM98_RS22350	COG0006	proline dipeptidase activity
HCM98_RS22365	COG3872	metal-dependent enzyme
HCM98_RS22375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HCM98_RS22410	COG0095	Lipoate-protein ligase
HCM98_RS22415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCM98_RS22425	COG1609	Transcriptional regulator
HCM98_RS22435	COG2076	Multidrug Resistance protein
HCM98_RS22440	COG2076	Multidrug Resistance protein
HCM98_RS22480	COG1725	Transcriptional regulator
HCM98_RS22510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCM98_RS22565	COG4970	Tfp pilus assembly protein FimT
HCM98_RS22575	COG1459	type II secretion system
HCM98_RS22580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HCM98_RS22635	COG0646	methionine synthase
HCM98_RS22635	COG1410	methionine synthase
HCM98_RS22640	COG0646	methionine synthase
HCM98_RS22640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HCM98_RS22645	COG0626	cystathionine gamma-synthase activity
HCM98_RS22650	COG0626	cystathionine gamma-synthase activity
HCM98_RS22670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS22680	COG1940	carbohydrate kinase activity
HCM98_RS22685	COG4483	Protein conserved in bacteria
HCM98_RS22690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HCM98_RS22695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HCM98_RS22700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HCM98_RS22705	COG0704	Plays a role in the regulation of phosphate uptake
HCM98_RS22715	COG0581	inorganic phosphate transmembrane transporter activity
HCM98_RS22720	COG0573	inorganic phosphate transmembrane transporter activity
HCM98_RS22725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HCM98_RS22730	COG0768	penicillin binding
HCM98_RS22735	COG0477	Major facilitator Superfamily
HCM98_RS22740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCM98_RS22765	COG0735	belongs to the Fur family
HCM98_RS22770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HCM98_RS22775	COG1121	(ABC) transporter
HCM98_RS22780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS22810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HCM98_RS22815	COG2384	SAM-dependent methyltransferase
HCM98_RS22820	COG2010	Cytochrome c
HCM98_RS22825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HCM98_RS22830	COG0358	DNA primase activity
HCM98_RS22840	COG0517	IMP dehydrogenase activity
HCM98_RS22855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HCM98_RS22860	COG0295	cytidine deaminase activity
HCM98_RS22865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HCM98_RS22875	COG1480	7TM receptor with intracellular HD hydrolase
HCM98_RS22880	COG1702	phosphate starvation-inducible protein PhoH
HCM98_RS22895	COG1610	YqeY-like protein
HCM98_RS22900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HCM98_RS22905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HCM98_RS22910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HCM98_RS22940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HCM98_RS22945	COG1733	regulation of RNA biosynthetic process
HCM98_RS22970	COG1466	dna polymerase III delta subunit
HCM98_RS22980	COG0658	competence protein
HCM98_RS22980	COG2333	competence protein COMEC
HCM98_RS22985	COG2131	deaminase
HCM98_RS22990	COG1555	photosystem II stabilization
HCM98_RS22990	COG1596	polysaccharide export
HCM98_RS22995	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HCM98_RS23000	COG2226	methyltransferase
HCM98_RS23005	COG0799	negative regulation of ribosome biogenesis
HCM98_RS23010	COG1713	HD superfamily hydrolase involved in NAD metabolism
HCM98_RS23020	COG1534	Rna-binding protein
HCM98_RS23030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HCM98_RS23035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCM98_RS23075	COG2357	RelA SpoT domain protein
HCM98_RS23085	COG1785	Belongs to the alkaline phosphatase family
HCM98_RS23095	COG2267	carboxylic ester hydrolase activity
HCM98_RS23130	COG1404	Belongs to the peptidase S8 family
HCM98_RS23135	COG3186	Phenylalanine-4-hydroxylase
HCM98_RS23145	COG2514	catechol 2,3-dioxygenase activity
HCM98_RS23150	COG2259	Doxx family
HCM98_RS23190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS23200	COG1012	belongs to the aldehyde dehydrogenase family
HCM98_RS23200	COG1454	alcohol dehydrogenase
HCM98_RS23205	COG0626	cystathionine gamma-synthase activity
HCM98_RS23210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCM98_RS23235	COG0768	penicillin binding
HCM98_RS23250	COG0826	peptidase U32
HCM98_RS23255	COG0826	peptidase U32
HCM98_RS23260	COG4122	O-methyltransferase activity
HCM98_RS23265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HCM98_RS23295	COG0628	permease
HCM98_RS23315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HCM98_RS23330	COG1104	cysteine desulfurase activity
HCM98_RS23335	COG1959	2 iron, 2 sulfur cluster binding
HCM98_RS23340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HCM98_RS23350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HCM98_RS23375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HCM98_RS23385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HCM98_RS23385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HCM98_RS23390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HCM98_RS23395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCM98_RS23395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HCM98_RS23405	COG2244	polysaccharide biosynthetic process
HCM98_RS23410	COG2323	membrane
HCM98_RS23415	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS23425	COG1862	Preprotein translocase
HCM98_RS23455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HCM98_RS23465	COG0697	spore germination
HCM98_RS23470	COG0640	Transcriptional regulator
HCM98_RS23495	COG0157	Belongs to the NadC ModD family
HCM98_RS23500	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HCM98_RS23505	COG1104	cysteine desulfurase activity
HCM98_RS23510	COG1827	regulation of RNA biosynthetic process
HCM98_RS23515	COG2258	MOSC domain
HCM98_RS23520	COG0077	Prephenate dehydratase
HCM98_RS23525	COG0577	efflux transmembrane transporter activity
HCM98_RS23530	COG0577	efflux transmembrane transporter activity
HCM98_RS23535	COG1136	(ABC) transporter
HCM98_RS23540	COG5002	protein histidine kinase activity
HCM98_RS23545	COG0745	RESPONSE REGULATOR receiver
HCM98_RS23555	COG3290	protein histidine kinase activity
HCM98_RS23565	COG2868	ribosomal protein
HCM98_RS23575	COG1530	ribonuclease E activity
HCM98_RS23580	COG1994	Peptidase M50
HCM98_RS23585	COG0739	heme binding
HCM98_RS23590	COG2894	cell division
HCM98_RS23610	COG1077	Cell shape determining protein MreB Mrl
HCM98_RS23630	COG0285	dihydrofolate synthase activity
HCM98_RS23645	COG1388	LysM domain
HCM98_RS23655	COG0113	porphobilinogen synthase activity
HCM98_RS23660	COG1587	Uroporphyrinogen-III synthase
HCM98_RS23670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HCM98_RS23680	COG1846	Transcriptional regulator
HCM98_RS23685	COG1764	response to oxidative stress
HCM98_RS23700	COG0470	DNA polymerase III
HCM98_RS23700	COG1067	ATP-dependent peptidase activity
HCM98_RS23760	COG0622	Phosphoesterase
HCM98_RS23775	COG5401	PFAM Sporulation and spore germination
HCM98_RS23795	COG1309	transcriptional regulator
HCM98_RS23805	COG2197	response regulator
HCM98_RS23810	COG2233	PERMEase
HCM98_RS23815	COG0402	S-adenosylhomocysteine deaminase activity
HCM98_RS23820	COG1983	PspC domain protein
HCM98_RS23825	COG1396	sequence-specific DNA binding
HCM98_RS23830	COG0697	spore germination
HCM98_RS23840	COG1959	2 iron, 2 sulfur cluster binding
HCM98_RS23845	COG1668	transmembrane transport
HCM98_RS23850	COG4152	abc transporter atp-binding protein
HCM98_RS23855	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HCM98_RS23860	COG1360	Flagellar Motor Protein
HCM98_RS23865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HCM98_RS23870	COG1876	peptidase activity
HCM98_RS23875	COG0824	Thioesterase
HCM98_RS23880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HCM98_RS23885	COG1053	succinate dehydrogenase
HCM98_RS23890	COG2009	succinate dehydrogenase
HCM98_RS23895	COG1719	4-vinyl reductase, 4VR
HCM98_RS23905	COG3118	belongs to the thioredoxin family
HCM98_RS23910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HCM98_RS23915	COG2086	electron transfer activity
HCM98_RS23920	COG1024	Enoyl-CoA hydratase
HCM98_RS23925	COG1309	transcriptional regulator
HCM98_RS23930	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS23940	COG2318	DinB family
HCM98_RS23970	COG1131	(ABC) transporter
HCM98_RS23975	COG2205	protein histidine kinase activity
HCM98_RS23980	COG0745	RESPONSE REGULATOR receiver
HCM98_RS23990	COG4895	conserved protein (DUF2196)
HCM98_RS23995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HCM98_RS24005	COG4509	Sortase family
HCM98_RS24010	COG1120	ATPase activity
HCM98_RS24025	COG5386	Cell surface protein
HCM98_RS24035	COG5386	Cell surface protein
HCM98_RS24040	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS24045	COG1187	pseudouridine synthase activity
HCM98_RS24055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HCM98_RS24055	COG1796	DNA polymerase
HCM98_RS24060	COG1286	toxin biosynthetic process
HCM98_RS24105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HCM98_RS24115	COG1418	mRNA catabolic process
HCM98_RS24125	COG2814	Major facilitator Superfamily
HCM98_RS24130	COG1566	PFAM secretion protein HlyD family protein
HCM98_RS24135	COG1309	transcriptional regulator
HCM98_RS24140	COG1363	Peptidase, m42
HCM98_RS24165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HCM98_RS24175	COG1484	DNA-dependent DNA replication
HCM98_RS24180	COG3611	Membrane attachment protein
HCM98_RS24190	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HCM98_RS24195	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCM98_RS24200	COG0237	dephospho-CoA kinase activity
HCM98_RS24205	COG1971	Probably functions as a manganese efflux pump
HCM98_RS24215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCM98_RS24215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HCM98_RS24220	COG5002	protein histidine kinase activity
HCM98_RS24225	COG0745	RESPONSE REGULATOR receiver
HCM98_RS24245	COG0538	isocitrate dehydrogenase activity
HCM98_RS24250	COG0372	Belongs to the citrate synthase family
HCM98_RS24260	COG0628	permease
HCM98_RS24265	COG3030	protein affecting phage T7 exclusion by the F plasmid
HCM98_RS24290	COG1725	Transcriptional regulator
HCM98_RS24295	COG0281	malic enzyme
HCM98_RS24300	COG0587	DNA-directed DNA polymerase activity
HCM98_RS24315	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HCM98_RS24335	COG4109	DRTGG domain
HCM98_RS24350	COG0006	proline dipeptidase activity
HCM98_RS24405	COG0662	Cupin 2, conserved barrel domain protein
HCM98_RS24415	COG1476	TRANSCRIPTIONal
HCM98_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
HCM98_RS24435	COG0589	response to stress
HCM98_RS24475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS24500	COG0827	DNA restriction-modification system
HCM98_RS24505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HCM98_RS24510	COG3874	Sporulation protein YtfJ
HCM98_RS24525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCM98_RS24535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCM98_RS24550	COG1104	cysteine desulfurase activity
HCM98_RS24560	COG0583	DNA-binding transcription factor activity
HCM98_RS24565	COG0697	spore germination
HCM98_RS24570	COG1309	transcriptional regulator
HCM98_RS24575	COG1956	GAF domain-containing protein
HCM98_RS24580	COG0626	cystathionine gamma-synthase activity
HCM98_RS24635	COG1595	DNA-templated transcription, initiation
HCM98_RS24650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HCM98_RS24655	COG0454	-acetyltransferase
HCM98_RS24660	COG0517	IMP dehydrogenase activity
HCM98_RS24665	COG0123	including yeast histone deacetylase and acetoin utilization protein
HCM98_RS24670	COG2267	carboxylic ester hydrolase activity
HCM98_RS24680	COG0745	RESPONSE REGULATOR receiver
HCM98_RS24685	COG5002	protein histidine kinase activity
HCM98_RS24690	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS24695	COG0666	response to abiotic stimulus
HCM98_RS24730	COG1609	Transcriptional regulator
HCM98_RS24735	COG4851	CamS sex pheromone cAM373 precursor
HCM98_RS24740	COG3118	belongs to the thioredoxin family
HCM98_RS24750	COG2309	aminopeptidase activity
HCM98_RS24775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS24780	COG0697	spore germination
HCM98_RS24785	COG0789	Transcriptional regulator
HCM98_RS24790	COG1695	Transcriptional regulator
HCM98_RS24810	COG1674	ftsk spoiiie
HCM98_RS24825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HCM98_RS24835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCM98_RS24840	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HCM98_RS24845	COG1363	Peptidase, m42
HCM98_RS24855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS24870	COG0510	thiamine kinase activity
HCM98_RS24875	COG1523	belongs to the glycosyl hydrolase 13 family
HCM98_RS24885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HCM98_RS24890	COG1349	DNA-binding transcription factor activity
HCM98_RS24895	COG1187	pseudouridine synthase activity
HCM98_RS24900	COG2244	polysaccharide biosynthetic process
HCM98_RS24905	COG2081	HI0933 family
HCM98_RS24910	COG2814	Major facilitator Superfamily
HCM98_RS24920	COG3832	glyoxalase III activity
HCM98_RS24940	COG1329	Transcriptional regulator
HCM98_RS24965	COG0314	molybdopterin synthase activity
HCM98_RS24970	COG1763	Mo-molybdopterin cofactor biosynthetic process
HCM98_RS24975	COG0303	'Molybdopterin
HCM98_RS24985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HCM98_RS24990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HCM98_RS25010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HCM98_RS25020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HCM98_RS25065	COG2814	Major facilitator Superfamily
HCM98_RS25085	COG0490	domain, Protein
HCM98_RS25090	COG0582	viral genome integration into host DNA
HCM98_RS25100	COG1136	(ABC) transporter
HCM98_RS25120	COG1242	4 iron, 4 sulfur cluster binding
HCM98_RS25125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HCM98_RS25130	COG1131	(ABC) transporter
HCM98_RS25140	COG1794	racemase activity, acting on amino acids and derivatives
HCM98_RS25165	COG2267	carboxylic ester hydrolase activity
HCM98_RS25170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HCM98_RS25175	COG0671	phosphoesterase, PA-phosphatase related
HCM98_RS25180	COG0438	transferase activity, transferring glycosyl groups
HCM98_RS25190	COG0521	Mo-molybdopterin cofactor biosynthetic process
HCM98_RS25270	COG5002	protein histidine kinase activity
HCM98_RS25275	COG4191	Histidine kinase
HCM98_RS25280	COG2267	carboxylic ester hydrolase activity
HCM98_RS25285	COG1368	sulfuric ester hydrolase activity
HCM98_RS25300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HCM98_RS25305	COG1116	anion transmembrane transporter activity
HCM98_RS25310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HCM98_RS25325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HCM98_RS25345	COG0494	nUDIX hydrolase
HCM98_RS25385	COG0288	reversible hydration of carbon dioxide
HCM98_RS25390	COG1271	oxidase subunit
HCM98_RS25395	COG1294	oxidase, subunit
HCM98_RS25420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS25445	COG1842	Phage shock protein A
HCM98_RS25490	COG5002	protein histidine kinase activity
HCM98_RS25495	COG0745	RESPONSE REGULATOR receiver
HCM98_RS25520	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HCM98_RS25525	COG1597	lipid kinase activity
HCM98_RS25555	COG1136	(ABC) transporter
HCM98_RS25590	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS25620	COG0577	efflux transmembrane transporter activity
HCM98_RS25625	COG1136	(ABC) transporter
HCM98_RS25630	COG2207	Transcriptional regulator
HCM98_RS25630	COG3708	Transcriptional regulator
HCM98_RS25635	COG5658	integral membrane protein
HCM98_RS25640	COG0640	Transcriptional regulator
HCM98_RS25645	COG0745	RESPONSE REGULATOR receiver
HCM98_RS25650	COG2205	protein histidine kinase activity
HCM98_RS25655	COG0577	efflux transmembrane transporter activity
HCM98_RS25660	COG0577	efflux transmembrane transporter activity
HCM98_RS25665	COG1136	(ABC) transporter
HCM98_RS25670	COG0577	efflux transmembrane transporter activity
HCM98_RS25695	COG2188	Transcriptional regulator
HCM98_RS25715	COG3964	amidohydrolase
HCM98_RS25735	COG4948	Mandelate Racemase Muconate Lactonizing
HCM98_RS25745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HCM98_RS25750	COG0596	Alpha beta hydrolase
HCM98_RS25760	COG1169	isochorismate synthase
HCM98_RS25765	COG1575	Belongs to the MenA family. Type 1 subfamily
HCM98_RS25770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HCM98_RS25795	COG0058	SHG alpha-glucan phosphorylase activity
HCM98_RS25805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HCM98_RS25825	COG1404	Belongs to the peptidase S8 family
HCM98_RS25840	COG1595	DNA-templated transcription, initiation
HCM98_RS25935	COG0544	peptidyl-prolyl cis-trans isomerase activity
HCM98_RS25970	COG1285	pathogenesis
HCM98_RS25975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCM98_RS25990	COG2155	Conserved Protein
HCM98_RS25995	COG1098	S1 RNA binding domain
HCM98_RS26000	COG0436	Aminotransferase
HCM98_RS26005	COG1522	sequence-specific DNA binding
HCM98_RS26010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HCM98_RS26015	COG2267	carboxylic ester hydrolase activity
HCM98_RS26025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HCM98_RS26045	COG5018	Exonuclease
HCM98_RS26050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCM98_RS26070	COG2050	protein possibly involved in aromatic compounds catabolism
HCM98_RS26080	COG1268	BioY protein
HCM98_RS26085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HCM98_RS26090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HCM98_RS26105	COG3584	3D domain protein
HCM98_RS26120	COG1252	NADH dehydrogenase
HCM98_RS26130	COG3708	Transcriptional regulator
HCM98_RS26145	COG1683	Conserved Protein
HCM98_RS26245	COG0740	serine-type endopeptidase activity
HCM98_RS26255	COG1802	Transcriptional regulator
HCM98_RS26255	COG4626	Terminase
HCM98_RS26385	COG1396	sequence-specific DNA binding
HCM98_RS26430	COG0316	Belongs to the HesB IscA family
HCM98_RS26445	COG1252	NADH dehydrogenase
HCM98_RS26460	COG0390	transport system, permease component
HCM98_RS26465	COG2824	Alkylphosphonate utilization operon protein PhnA
HCM98_RS26480	COG4837	Protein of unknown function (DUF1462)
HCM98_RS26485	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HCM98_RS26495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HCM98_RS26500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HCM98_RS26515	COG1136	(ABC) transporter
HCM98_RS26515	COG0577	efflux transmembrane transporter activity
HCM98_RS26525	COG2249	NAD(P)H dehydrogenase (quinone) activity
HCM98_RS26535	COG0647	UMP catabolic process
HCM98_RS26545	COG2445	Protein of unknown function DUF86
HCM98_RS26550	COG1494	fructose-1,6-bisphosphatase
HCM98_RS26565	COG4470	Protein conserved in bacteria
HCM98_RS26575	COG0789	Transcriptional regulator
HCM98_RS26580	COG4377	Putative membrane peptidase family (DUF2324)
HCM98_RS26605	COG0739	heme binding
HCM98_RS26615	COG3377	Domain of unknown function (DUF1805)
HCM98_RS26620	COG0737	Belongs to the 5'-nucleotidase family
HCM98_RS26625	COG1695	Transcriptional regulator
HCM98_RS26635	COG0719	Fe-S assembly protein
HCM98_RS26640	COG0822	iron-sulfur transferase activity
HCM98_RS26645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HCM98_RS26650	COG0719	Fe-S assembly protein
HCM98_RS26655	COG0396	ATPase activity
HCM98_RS26660	COG1464	Belongs to the NlpA lipoprotein family
HCM98_RS26665	COG1464	Belongs to the NlpA lipoprotein family
HCM98_RS26670	COG2011	ABC-type metal ion transport system permease component
HCM98_RS26675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HCM98_RS26685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HCM98_RS26690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCM98_RS26700	COG1393	Belongs to the ArsC family
HCM98_RS26760	COG1309	transcriptional regulator
HCM98_RS26765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HCM98_RS26770	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS26775	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS26785	COG0183	Belongs to the thiolase family
HCM98_RS26790	COG1024	Enoyl-CoA hydratase
HCM98_RS26790	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCM98_RS26800	COG1686	Belongs to the peptidase S11 family
HCM98_RS26815	COG0011	TIGRFAM Protein of
HCM98_RS26820	COG0840	transmembrane signaling receptor activity
HCM98_RS26840	COG2814	Major facilitator Superfamily
HCM98_RS26845	COG0531	amino acid
HCM98_RS26870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HCM98_RS26910	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS26925	COG0745	RESPONSE REGULATOR receiver
HCM98_RS26930	COG5002	protein histidine kinase activity
HCM98_RS26955	COG0840	transmembrane signaling receptor activity
HCM98_RS26960	COG2151	metal-sulfur cluster biosynthetic enzyme
HCM98_RS26965	COG3227	Zinc metalloprotease (Elastase)
HCM98_RS26970	COG1741	Belongs to the pirin family
HCM98_RS26985	COG0586	Pfam SNARE associated Golgi protein
HCM98_RS26990	COG0475	glutathione-regulated potassium exporter activity
HCM98_RS26995	COG0490	domain, Protein
HCM98_RS27000	COG1115	amino acid carrier protein
HCM98_RS27005	COG0783	Belongs to the Dps family
HCM98_RS27025	COG1611	Belongs to the LOG family
HCM98_RS27035	COG1528	Iron-storage protein
HCM98_RS27045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS27050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS27055	COG1115	amino acid carrier protein
HCM98_RS27060	COG1115	amino acid carrier protein
HCM98_RS27065	COG2910	NAD(P)H-binding
HCM98_RS27085	COG0656	L-ascorbic acid biosynthetic process
HCM98_RS27090	COG2814	Major facilitator Superfamily
HCM98_RS27095	COG1733	regulation of RNA biosynthetic process
HCM98_RS27105	COG1252	NADH dehydrogenase
HCM98_RS27110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HCM98_RS27125	COG3290	protein histidine kinase activity
HCM98_RS27125	COG0840	transmembrane signaling receptor activity
HCM98_RS27135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HCM98_RS27155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HCM98_RS27220	COG0557	exoribonuclease II activity
HCM98_RS27225	COG1647	Serine aminopeptidase, S33
HCM98_RS27230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HCM98_RS27235	COG1346	cytolysis
HCM98_RS27250	COG0148	phosphopyruvate hydratase activity
HCM98_RS27270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HCM98_RS27285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HCM98_RS27295	COG1668	transmembrane transport
HCM98_RS27300	COG4152	abc transporter atp-binding protein
HCM98_RS27305	COG4585	Histidine kinase
HCM98_RS27335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HCM98_RS27350	COG2323	membrane
HCM98_RS27360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HCM98_RS27370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HCM98_RS27380	COG1051	belongs to the nudix hydrolase family
HCM98_RS27390	COG0492	ferredoxin-NADP+ reductase activity
HCM98_RS27395	COG0457	Tetratricopeptide repeat
HCM98_RS27400	COG0110	maltose O-acetyltransferase activity
HCM98_RS27420	COG1950	PFAM Membrane protein of
HCM98_RS27430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HCM98_RS27450	COG0789	Transcriptional regulator
HCM98_RS27485	COG0583	DNA-binding transcription factor activity
HCM98_RS27495	COG0655	NAD(P)H dehydrogenase (quinone) activity
HCM98_RS27505	COG1132	(ABC) transporter
HCM98_RS27510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCM98_RS27515	COG0793	Belongs to the peptidase S41A family
HCM98_RS27515	COG3409	Peptidoglycan-binding domain 1 protein
HCM98_RS27520	COG2177	Part of the ABC transporter FtsEX involved in
HCM98_RS27525	COG2884	Cell division ATP-binding protein ftsE
HCM98_RS27545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HCM98_RS27550	COG1278	Cold shock
HCM98_RS27555	COG1040	competence protein
HCM98_RS27560	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HCM98_RS27565	COG1388	LysM domain
HCM98_RS27565	COG0791	NLP P60 protein
HCM98_RS27570	COG1733	regulation of RNA biosynthetic process
HCM98_RS27575	COG1307	EDD domain protein, DegV family
HCM98_RS27580	COG1739	Uncharacterized protein family UPF0029
HCM98_RS27585	COG1316	TRANSCRIPTIONal
HCM98_RS27590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCM98_RS27595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HCM98_RS27600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HCM98_RS27610	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HCM98_RS27610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HCM98_RS27630	COG1486	melibiose metabolic process
HCM98_RS27635	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCM98_RS27640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCM98_RS27660	COG1447	Phosphotransferase system cellobiose-specific component IIA
HCM98_RS27670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HCM98_RS27675	COG1301	dicarboxylic acid transport
HCM98_RS27680	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS27690	COG0346	lactoylglutathione lyase activity
HCM98_RS27695	COG1511	domain protein
HCM98_RS27700	COG0583	DNA-binding transcription factor activity
HCM98_RS27705	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HCM98_RS27715	COG1271	oxidase subunit
HCM98_RS27720	COG1294	oxidase, subunit
HCM98_RS27725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HCM98_RS27735	COG1620	l-lactate permease
HCM98_RS27745	COG2389	metal-binding protein
HCM98_RS27755	COG1368	sulfuric ester hydrolase activity
HCM98_RS27765	COG0791	NLP P60 protein
HCM98_RS27765	COG1388	LysM domain
HCM98_RS27770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HCM98_RS27780	COG1215	transferase activity, transferring glycosyl groups
HCM98_RS27785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCM98_RS27790	COG3584	3D domain protein
HCM98_RS27790	COG1388	LysM domain
HCM98_RS27815	COG4715	Zinc finger, swim domain protein
HCM98_RS27820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HCM98_RS27870	COG0577	efflux transmembrane transporter activity
HCM98_RS27875	COG1136	(ABC) transporter
HCM98_RS27900	COG5002	protein histidine kinase activity
HCM98_RS27905	COG0745	RESPONSE REGULATOR receiver
HCM98_RS27910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCM98_RS27915	COG4464	protein tyrosine phosphatase activity
HCM98_RS27935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HCM98_RS27940	COG1134	teichoic acid transport
HCM98_RS27945	COG1682	transport, permease protein
HCM98_RS27950	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HCM98_RS27990	COG1609	Transcriptional regulator
HCM98_RS28005	COG0739	heme binding
HCM98_RS28020	COG3279	Response regulator of the LytR AlgR family
HCM98_RS28025	COG0318	PFAM AMP-dependent synthetase and ligase
HCM98_RS28030	COG2385	sporulation resulting in formation of a cellular spore
HCM98_RS28045	COG4836	Membrane
HCM98_RS28050	COG1007	ATP synthesis coupled electron transport
HCM98_RS28055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCM98_RS28060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HCM98_RS28070	COG0839	Belongs to the complex I subunit 6 family
HCM98_RS28090	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HCM98_RS28105	COG3300	MHYT domain
HCM98_RS28105	COG5001	Diguanylate cyclase
HCM98_RS28155	COG0356	it plays a direct role in the translocation of protons across the membrane
HCM98_RS28190	COG0698	ribose 5-phosphate isomerase
HCM98_RS28200	COG2190	(PTS) system
HCM98_RS28205	COG2259	Doxx family
HCM98_RS28210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HCM98_RS28225	COG0009	L-threonylcarbamoyladenylate synthase
HCM98_RS28240	COG2890	protein-(glutamine-N5) methyltransferase activity
HCM98_RS28260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HCM98_RS28265	COG1494	fructose-1,6-bisphosphatase
HCM98_RS28285	COG4821	SIS domain
HCM98_RS28295	COG3343	RNA polymerase activity
HCM98_RS28305	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS28310	COG1960	acyl-CoA dehydrogenase activity
HCM98_RS28315	COG1250	3-hydroxyacyl-CoA dehydrogenase
HCM98_RS28320	COG0183	Belongs to the thiolase family
HCM98_RS28325	COG2181	nitrate reductase activity
HCM98_RS28325	COG0247	lactate metabolic process
HCM98_RS28330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HCM98_RS28340	COG3300	MHYT domain
HCM98_RS28340	COG5001	Diguanylate cyclase
HCM98_RS28365	COG2197	response regulator
HCM98_RS28370	COG4585	Histidine kinase
HCM98_RS28375	COG0842	Transport permease protein
HCM98_RS28380	COG1131	(ABC) transporter
HCM98_RS28385	COG0024	Methionine aminopeptidase
HCM98_RS28390	COG2234	aminopeptidase activity
HCM98_RS28440	COG4506	Protein conserved in bacteria
HCM98_RS28445	COG1619	proteins homologs of microcin C7 resistance protein MccF
HCM98_RS28470	COG2814	Major facilitator Superfamily
HCM98_RS28475	COG0789	Transcriptional regulator
HCM98_RS28480	COG0584	glycerophosphoryl diester phosphodiesterase
HCM98_RS28485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HCM98_RS28495	COG1994	Peptidase M50
HCM98_RS28505	COG1078	dGTPase activity
HCM98_RS28510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HCM98_RS28515	COG1120	ATPase activity
HCM98_RS28520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS28525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HCM98_RS28550	COG0280	phosphate acetyltransferase
HCM98_RS28565	COG3773	Cell wall hydrolase
HCM98_RS28575	COG2363	Small membrane protein
HCM98_RS28585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HCM98_RS28590	COG2233	PERMEase
HCM98_RS28595	COG0561	phosphatase activity
HCM98_RS28600	COG2814	Major facilitator Superfamily
HCM98_RS28610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HCM98_RS28615	COG1131	(ABC) transporter
HCM98_RS28620	COG2755	lipolytic protein G-D-S-L family
HCM98_RS28625	COG1609	Transcriptional regulator
HCM98_RS28635	COG0460	homoserine dehydrogenase
HCM98_RS28645	COG2873	o-acetylhomoserine
HCM98_RS28655	COG1011	Hydrolase
HCM98_RS28670	COG2197	response regulator
HCM98_RS28675	COG4585	Histidine kinase
HCM98_RS28675	COG2203	Gaf domain
HCM98_RS28680	COG0351	phosphomethylpyrimidine kinase
HCM98_RS28685	COG3706	GGDEF domain
HCM98_RS28690	COG2879	small protein
HCM98_RS28710	COG3279	Response regulator of the LytR AlgR family
HCM98_RS28715	COG0477	Major facilitator Superfamily
HCM98_RS28740	COG0840	transmembrane signaling receptor activity
HCM98_RS28750	COG1607	acyl-coa hydrolase
HCM98_RS28770	COG0488	(ABC) transporter
HCM98_RS28790	COG0463	Glycosyl transferase, family 2
HCM98_RS28795	COG1309	transcriptional regulator
HCM98_RS28800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HCM98_RS28805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCM98_RS28805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HCM98_RS28810	COG0628	permease
HCM98_RS28825	COG3279	Response regulator of the LytR AlgR family
HCM98_RS28830	COG3275	phosphorelay sensor kinase activity
HCM98_RS28835	COG2814	Major facilitator Superfamily
HCM98_RS28840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HCM98_RS28845	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HCM98_RS28850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HCM98_RS28870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HCM98_RS28875	COG1272	protein, Hemolysin III
HCM98_RS28905	COG1164	Oligoendopeptidase f
HCM98_RS28930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HCM98_RS28935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HCM98_RS28940	COG4853	Protein conserved in bacteria
HCM98_RS28945	COG4863	YycH protein
HCM98_RS28950	COG5002	protein histidine kinase activity
HCM98_RS28955	COG0745	RESPONSE REGULATOR receiver
HCM98_RS28985	COG0305	Participates in initiation and elongation during chromosome replication
HCM98_RS28995	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HCM98_RS29000	COG4241	membrane
HCM98_RS29010	COG0629	single-stranded DNA binding
HCM98_RS29020	COG0012	GTP binding
HCM98_RS29025	COG4481	Protein conserved in bacteria
HCM98_RS29030	COG0668	transmembrane transport
HCM98_RS29040	COG1475	DNA binding
HCM98_RS29045	COG1192	Involved in chromosome partitioning
HCM98_RS29070	COG1847	R3H domain protein
HCM98_RS29075	COG0706	membrane insertase activity
HCM98_RS29085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HCM98_RS29095	COG0592	DNA-directed DNA polymerase activity
HCM98_RS29100	COG2501	S4 domain
HCM98_RS29110	COG0187	DNA topoisomerase II activity
HCM98_RS29115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HCM98_RS29150	COG0516	GMP reductase activity
HCM98_RS29150	COG0517	IMP dehydrogenase activity
HCM98_RS29155	COG1686	Belongs to the peptidase S11 family
HCM98_RS29185	COG1428	Deoxynucleoside kinase
HCM98_RS29190	COG1428	Deoxynucleoside kinase
HCM98_RS29195	COG1335	isochorismatase
HCM98_RS29200	COG0590	tRNA wobble adenosine to inosine editing
HCM98_RS29210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HCM98_RS29265	COG1982	Orn Lys Arg decarboxylase major
HCM98_RS29275	COG0470	DNA polymerase III
HCM98_RS29280	COG1774	PSP1 C-terminal conserved region
HCM98_RS29285	COG4467	Involved in initiation control of chromosome replication
HCM98_RS29290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HCM98_RS29300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HCM98_RS29305	COG2002	toxin-antitoxin pair type II binding
HCM98_RS29315	COG0084	hydrolase, TatD family'
HCM98_RS29320	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HCM98_RS29335	COG4466	Protein conserved in bacteria
HCM98_RS29350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HCM98_RS29355	COG0251	oxidation-reduction process
HCM98_RS29385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HCM98_RS29390	COG2002	toxin-antitoxin pair type II binding
HCM98_RS29395	COG2244	polysaccharide biosynthetic process
HCM98_RS29400	COG3956	TIGRFAM MazG family protein
HCM98_RS29405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HCM98_RS29425	COG1098	S1 RNA binding domain
HCM98_RS29440	COG2208	phosphoserine phosphatase activity
HCM98_RS29450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HCM98_RS29455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HCM98_RS29470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HCM98_RS29475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HCM98_RS29480	COG0512	Glutamine amidotransferase of anthranilate synthase
HCM98_RS29485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HCM98_RS29490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HCM98_RS29495	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HCM98_RS29500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HCM98_RS29505	COG1396	sequence-specific DNA binding
HCM98_RS29510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HCM98_RS29530	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS29545	COG0463	Glycosyl transferase, family 2
HCM98_RS29650	COG1181	Belongs to the D-alanine--D-alanine ligase family
HCM98_RS29680	COG2963	transposase activity
HCM98_RS29710	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS29720	COG4974	Belongs to the 'phage' integrase family
HCM98_RS29750	COG1114	Component of the transport system for branched-chain amino acids
HCM98_RS29755	COG1301	dicarboxylic acid transport
HCM98_RS29955	COG3706	GGDEF domain
HCM98_RS29995	COG2378	regulation of single-species biofilm formation
HCM98_RS30080	COG2801	Transposase and inactivated derivatives
HCM98_RS30105	COG5002	protein histidine kinase activity
HCM98_RS30125	COG0745	RESPONSE REGULATOR receiver
HCM98_RS30255	COG0776	regulation of translation
HCM98_RS30260	COG1923	regulation of RNA biosynthetic process
HCM98_RS30265	COG2002	toxin-antitoxin pair type II binding
HCM98_RS30295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HCM98_RS30415	COG0457	Tetratricopeptide repeat
HCM98_RS30445	COG1396	sequence-specific DNA binding
HCM98_RS30545	COG3505	Type IV secretory pathway VirD4
HCM98_RS30575	COG0791	NLP P60 protein
HCM98_RS30575	COG3883	PFAM NLP P60 protein
HCM98_RS30670	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS30675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HCM98_RS30705	COG2002	toxin-antitoxin pair type II binding
HCM98_RS30755	COG3335	DDE superfamily endonuclease
HCM98_RS30850	COG0577	efflux transmembrane transporter activity
HCM98_RS30855	COG1136	(ABC) transporter
HCM98_RS30925	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HCM98_RS30925	COG0493	'glutamate synthase
HCM98_RS30965	COG0582	viral genome integration into host DNA
HCM98_RS31000	COG1923	regulation of RNA biosynthetic process
HCM98_RS31005	COG2002	toxin-antitoxin pair type II binding
HCM98_RS31020	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HCM98_RS31045	COG1674	ftsk spoiiie
HCM98_RS31145	COG3547	Transposase (IS116 IS110 IS902 family)
HCM98_RS31175	COG0741	lytic transglycosylase activity
HCM98_RS31175	COG0791	NLP P60 protein
HCM98_RS31255	COG4644	lycopene metabolic process
HCM98_RS31415	COG0582	viral genome integration into host DNA
HCM98_RS31420	COG3209	COG3209 Rhs family protein
HCM98_RS31485	COG1192	Involved in chromosome partitioning
HCM98_RS31710	COG5444	nuclease activity
HCM98_RS31880	COG5444	nuclease activity
HCM98_RS31975	COG0328	RNA-DNA hybrid ribonuclease activity
HCM98_RS31975	COG3341	Caulimovirus viroplasmin
HCM98_RS31980	COG0328	RNA-DNA hybrid ribonuclease activity