locus-tag	class	description
M5J22_RS00010	COG0592	DNA-directed DNA polymerase activity
M5J22_RS00015	COG2501	S4 domain
M5J22_RS00030	COG0187	DNA topoisomerase II activity
M5J22_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5J22_RS00070	COG0516	GMP reductase activity
M5J22_RS00070	COG0517	IMP dehydrogenase activity
M5J22_RS00075	COG1686	Belongs to the peptidase S11 family
M5J22_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
M5J22_RS00105	COG1428	Deoxynucleoside kinase
M5J22_RS00110	COG1428	Deoxynucleoside kinase
M5J22_RS00115	COG1388	LysM domain
M5J22_RS00115	COG3858	chitin binding
M5J22_RS00120	COG1335	isochorismatase
M5J22_RS00125	COG0590	tRNA wobble adenosine to inosine editing
M5J22_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5J22_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5J22_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M5J22_RS00195	COG3853	Toxic anion resistance protein (TelA)
M5J22_RS00200	COG1982	Orn Lys Arg decarboxylase major
M5J22_RS00210	COG3870	Protein conserved in bacteria
M5J22_RS00215	COG1728	Protein conserved in bacteria
M5J22_RS00220	COG0470	DNA polymerase III
M5J22_RS00225	COG1774	PSP1 C-terminal conserved region
M5J22_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5J22_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5J22_RS00250	COG2002	toxin-antitoxin pair type II binding
M5J22_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5J22_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5J22_RS00260	COG0084	hydrolase, TatD family'
M5J22_RS00265	COG3583	domain protein
M5J22_RS00265	COG3584	3D domain protein
M5J22_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5J22_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5J22_RS00285	COG4466	Protein conserved in bacteria
M5J22_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5J22_RS00305	COG0251	oxidation-reduction process
M5J22_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5J22_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5J22_RS00345	COG2002	toxin-antitoxin pair type II binding
M5J22_RS00350	COG2244	polysaccharide biosynthetic process
M5J22_RS00355	COG3956	TIGRFAM MazG family protein
M5J22_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5J22_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5J22_RS00380	COG1098	S1 RNA binding domain
M5J22_RS00395	COG2208	phosphoserine phosphatase activity
M5J22_RS00400	COG2304	oxidoreductase activity
M5J22_RS00405	COG0515	serine threonine protein kinase
M5J22_RS00410	COG0037	tRNA processing
M5J22_RS00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M5J22_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5J22_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5J22_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5J22_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5J22_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
M5J22_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5J22_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5J22_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5J22_RS00475	COG1396	sequence-specific DNA binding
M5J22_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5J22_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5J22_RS00565	COG4463	regulation of RNA biosynthetic process
M5J22_RS00570	COG3880	PFAM UvrB UvrC protein
M5J22_RS00580	COG0542	response to heat
M5J22_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5J22_RS00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M5J22_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
M5J22_RS00615	COG1045	serine acetyltransferase
M5J22_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M5J22_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5J22_RS00635	COG3688	RNA-binding protein containing a PIN domain
M5J22_RS00640	COG1595	DNA-templated transcription, initiation
M5J22_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5J22_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
M5J22_RS00680	COG2813	Specifically methylates the guanine in position
M5J22_RS00695	COG1358	cellular component organization or biogenesis
M5J22_RS00720	COG0596	Alpha beta hydrolase
M5J22_RS00830	COG0201	protein transport
M5J22_RS00840	COG0024	Methionine aminopeptidase
M5J22_RS00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5J22_RS00880	COG1122	ATPase activity
M5J22_RS00885	COG1122	ATPase activity
M5J22_RS00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5J22_RS00910	COG2226	methyltransferase
M5J22_RS00915	COG2318	DinB family
M5J22_RS00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS00930	COG0489	protein tyrosine kinase activity
M5J22_RS00940	COG2194	sulfuric ester hydrolase activity
M5J22_RS00945	COG0726	polysaccharide deacetylase
M5J22_RS01005	COG0738	Major facilitator superfamily
M5J22_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS01025	COG0659	secondary active sulfate transmembrane transporter activity
M5J22_RS01030	COG0385	Bile acid
M5J22_RS01035	COG2819	hydrolase of the alpha beta superfamily
M5J22_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5J22_RS01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5J22_RS01055	COG2207	Transcriptional regulator
M5J22_RS01060	COG3876	Protein conserved in bacteria
M5J22_RS01065	COG1472	Belongs to the glycosyl hydrolase 3 family
M5J22_RS01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5J22_RS01075	COG1263	PTS System
M5J22_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5J22_RS01090	COG1683	Conserved Protein
M5J22_RS01120	COG1595	DNA-templated transcription, initiation
M5J22_RS01125	COG5662	AntiSigma factor
M5J22_RS01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5J22_RS01135	COG4856	YbbR-like protein
M5J22_RS01165	COG1346	cytolysis
M5J22_RS01170	COG1380	Effector of murein hydrolase LrgA
M5J22_RS01175	COG1846	Transcriptional regulator
M5J22_RS01180	COG1113	amino acid transport
M5J22_RS01185	COG1011	Hydrolase
M5J22_RS01190	COG4585	Histidine kinase
M5J22_RS01195	COG2197	response regulator
M5J22_RS01200	COG1131	(ABC) transporter
M5J22_RS01220	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M5J22_RS01240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS01240	COG3321	synthase
M5J22_RS01240	COG4221	oxidoreductase activity
M5J22_RS01245	COG0300	oxidoreductase activity
M5J22_RS01245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS01245	COG3321	synthase
M5J22_RS01245	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS01285	COG0531	amino acid
M5J22_RS01295	COG0584	glycerophosphoryl diester phosphodiesterase
M5J22_RS01300	COG2271	Major facilitator Superfamily
M5J22_RS01310	COG2368	4-hydroxyphenylacetate
M5J22_RS01320	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS01335	COG0371	Dehydrogenase
M5J22_RS01345	COG1183	phosphatidylcholine synthase activity
M5J22_RS01350	COG0586	Pfam SNARE associated Golgi protein
M5J22_RS01355	COG0688	phosphatidylethanolamine metabolic process
M5J22_RS01370	COG1301	dicarboxylic acid transport
M5J22_RS01375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS01380	COG0833	amino acid
M5J22_RS01385	COG2040	homocysteine
M5J22_RS01390	COG1115	amino acid carrier protein
M5J22_RS01395	COG2066	Belongs to the glutaminase family
M5J22_RS01400	COG4191	Histidine kinase
M5J22_RS01405	COG0784	Response regulator, receiver
M5J22_RS01410	COG3173	Aminoglycoside phosphotransferase
M5J22_RS01420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5J22_RS01425	COG0778	Nitroreductase
M5J22_RS01430	COG0346	lactoylglutathione lyase activity
M5J22_RS01435	COG2259	Doxx family
M5J22_RS01440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS01450	COG3773	Cell wall hydrolase
M5J22_RS01455	COG3540	Alkaline phosphatase
M5J22_RS01460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5J22_RS01465	COG0805	protein transport
M5J22_RS01475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5J22_RS01480	COG0477	Major facilitator Superfamily
M5J22_RS01485	COG1309	transcriptional regulator
M5J22_RS01490	COG0252	asparaginase activity
M5J22_RS01495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5J22_RS01500	COG1405	negative regulation of cell septum assembly
M5J22_RS01500	COG3012	SEC-C Motif Domain Protein
M5J22_RS01505	COG0667	Aldo Keto reductase
M5J22_RS01515	COG1595	DNA-templated transcription, initiation
M5J22_RS01520	COG1595	DNA-templated transcription, initiation
M5J22_RS01525	COG1876	peptidase activity
M5J22_RS01530	COG0457	Tetratricopeptide repeat
M5J22_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS01540	COG0366	Alpha amylase catalytic
M5J22_RS01545	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5J22_RS01550	COG1121	(ABC) transporter
M5J22_RS01555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5J22_RS01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS01565	COG2310	stress, protein
M5J22_RS01570	COG2310	stress, protein
M5J22_RS01575	COG2310	stress, protein
M5J22_RS01580	COG0861	Integral membrane protein TerC family
M5J22_RS01590	COG3853	Toxic anion resistance protein (TelA)
M5J22_RS01595	COG0477	Major facilitator Superfamily
M5J22_RS01600	COG0517	IMP dehydrogenase activity
M5J22_RS01600	COG4175	Glycine betaine
M5J22_RS01605	COG4176	ABC-type proline glycine betaine transport system permease component
M5J22_RS01610	COG2113	Glycine betaine
M5J22_RS01615	COG1473	amidohydrolase
M5J22_RS01620	COG1288	antiporter activity
M5J22_RS01630	COG0366	Alpha amylase catalytic
M5J22_RS01640	COG2814	Major facilitator Superfamily
M5J22_RS01645	COG1846	Transcriptional regulator
M5J22_RS01650	COG1280	lysine exporter protein (LysE YggA)
M5J22_RS01655	COG3403	YqcI/YcgG family
M5J22_RS01660	COG1113	amino acid transport
M5J22_RS01665	COG3665	Urea carboxylase-associated protein
M5J22_RS01680	COG1660	Displays ATPase and GTPase activities
M5J22_RS01690	COG2271	Major facilitator Superfamily
M5J22_RS01695	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5J22_RS01700	COG3458	cephalosporin-C deacetylase activity
M5J22_RS01705	COG3541	Predicted nucleotidyltransferase
M5J22_RS01710	COG0506	proline dehydrogenase activity
M5J22_RS01715	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS01720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5J22_RS01725	COG2508	Transcriptional regulator
M5J22_RS01735	COG1587	Uroporphyrinogen-III synthase
M5J22_RS01735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5J22_RS01740	COG2146	nitrite reductase [NAD(P)H] activity
M5J22_RS01745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5J22_RS01755	COG0523	cobalamin synthesis protein
M5J22_RS01760	COG1063	alcohol dehydrogenase
M5J22_RS01765	COG1714	RDD family
M5J22_RS01790	COG3209	COG3209 Rhs family protein
M5J22_RS01795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5J22_RS01800	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M5J22_RS01805	COG1733	regulation of RNA biosynthetic process
M5J22_RS01810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS01835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS01840	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M5J22_RS01855	COG2364	Membrane
M5J22_RS01860	COG1126	abc transporter atp-binding protein
M5J22_RS01865	COG0765	amino acid transport
M5J22_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS01875	COG0583	DNA-binding transcription factor activity
M5J22_RS01880	COG0163	prenyltransferase activity
M5J22_RS01885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M5J22_RS01900	COG3104	oligopeptide transport
M5J22_RS01905	COG5434	Belongs to the glycosyl hydrolase 28 family
M5J22_RS01915	COG0697	spore germination
M5J22_RS01925	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M5J22_RS01930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS01935	COG0456	acetyltransferase
M5J22_RS01940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS01945	COG0765	amino acid transport
M5J22_RS01950	COG1126	abc transporter atp-binding protein
M5J22_RS01955	COG1473	amidohydrolase
M5J22_RS01960	COG2079	MmgE PrpD family protein
M5J22_RS01965	COG1136	(ABC) transporter
M5J22_RS01970	COG0577	efflux transmembrane transporter activity
M5J22_RS01975	COG0745	RESPONSE REGULATOR receiver
M5J22_RS01980	COG3850	Histidine kinase
M5J22_RS01980	COG5002	protein histidine kinase activity
M5J22_RS01985	COG0457	Tetratricopeptide repeat
M5J22_RS02000	COG0527	aspartate kinase activity
M5J22_RS02005	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS02010	COG4605	iron ion homeostasis
M5J22_RS02015	COG4604	ABC transporter, ATP-binding protein
M5J22_RS02020	COG4607	ABC-type enterochelin transport system periplasmic component
M5J22_RS02025	COG2814	Major facilitator Superfamily
M5J22_RS02030	COG1309	transcriptional regulator
M5J22_RS02035	COG0778	Nitroreductase
M5J22_RS02040	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5J22_RS02045	COG0640	Transcriptional regulator
M5J22_RS02050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5J22_RS02055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS02060	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS02065	COG4975	Glucose uptake
M5J22_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS02075	COG4549	nuclear export factor GLE1
M5J22_RS02080	COG1276	copper resistance
M5J22_RS02080	COG2372	response to copper ion
M5J22_RS02085	COG1349	DNA-binding transcription factor activity
M5J22_RS02095	COG2213	PTS system mannitol-specific
M5J22_RS02100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS02110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5J22_RS02120	COG0561	phosphatase activity
M5J22_RS02130	COG1914	H( )-stimulated, divalent metal cation uptake system
M5J22_RS02140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5J22_RS02145	COG1984	allophanate hydrolase subunit 2
M5J22_RS02150	COG1414	Transcriptional regulator
M5J22_RS02155	COG2755	lipolytic protein G-D-S-L family
M5J22_RS02165	COG2329	Antibiotic biosynthesis monooxygenase
M5J22_RS02170	COG0768	penicillin binding
M5J22_RS02175	COG4989	oxidoreductase activity
M5J22_RS02180	COG3711	transcriptional antiterminator
M5J22_RS02185	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS02190	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS02195	COG1917	Cupin 2, conserved barrel domain protein
M5J22_RS02200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5J22_RS02205	COG3871	stress protein (general stress protein 26)
M5J22_RS02215	COG2814	Major facilitator Superfamily
M5J22_RS02220	COG1522	sequence-specific DNA binding
M5J22_RS02225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5J22_RS02225	COG0551	DNA topoisomerase type I activity
M5J22_RS02230	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5J22_RS02235	COG3706	GGDEF domain
M5J22_RS02240	COG5298	Protein conserved in bacteria
M5J22_RS02245	COG1215	transferase activity, transferring glycosyl groups
M5J22_RS02255	COG0531	amino acid
M5J22_RS02260	COG0494	nUDIX hydrolase
M5J22_RS02265	COG0028	Belongs to the TPP enzyme family
M5J22_RS02290	COG1914	H( )-stimulated, divalent metal cation uptake system
M5J22_RS02310	COG2076	Multidrug Resistance protein
M5J22_RS02315	COG2217	Heavy metal translocating P-type atpase
M5J22_RS02320	COG3729	General stress protein
M5J22_RS02325	COG0662	Cupin 2, conserved barrel domain protein
M5J22_RS02330	COG2329	Antibiotic biosynthesis monooxygenase
M5J22_RS02335	COG3546	catalase activity
M5J22_RS02340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5J22_RS02345	COG3290	protein histidine kinase activity
M5J22_RS02350	COG4565	transcriptional regulatory protein
M5J22_RS02355	COG1301	dicarboxylic acid transport
M5J22_RS02360	COG0628	permease
M5J22_RS02365	COG1131	(ABC) transporter
M5J22_RS02370	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5J22_RS02380	COG1960	acyl-CoA dehydrogenase activity
M5J22_RS02395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5J22_RS02400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS02410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5J22_RS02415	COG0513	Belongs to the DEAD box helicase family
M5J22_RS02420	COG3402	PFAM membrane-flanked domain
M5J22_RS02425	COG3428	Bacterial PH domain
M5J22_RS02430	COG0705	Rhomboid family
M5J22_RS02440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5J22_RS02445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5J22_RS02450	COG0864	Transcriptional regulator
M5J22_RS02455	COG2337	Toxic component of a toxin-antitoxin (TA) module
M5J22_RS02460	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS02465	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS02470	COG2172	sigma factor antagonist activity
M5J22_RS02475	COG2208	phosphoserine phosphatase activity
M5J22_RS02480	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS02490	COG1191	sigma factor activity
M5J22_RS02495	COG2208	phosphoserine phosphatase activity
M5J22_RS02500	COG2183	response to ionizing radiation
M5J22_RS02555	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5J22_RS02575	COG0477	Major facilitator Superfamily
M5J22_RS02585	COG1764	response to oxidative stress
M5J22_RS02590	COG1846	Transcriptional regulator
M5J22_RS02600	COG1959	2 iron, 2 sulfur cluster binding
M5J22_RS02605	COG2910	NAD(P)H-binding
M5J22_RS02610	COG1278	Cold shock
M5J22_RS02620	COG1937	Protein conserved in bacteria
M5J22_RS02625	COG2210	Belongs to the sulfur carrier protein TusA family
M5J22_RS02635	COG0425	Belongs to the sulfur carrier protein TusA family
M5J22_RS02635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5J22_RS02645	COG0425	Belongs to the sulfur carrier protein TusA family
M5J22_RS02650	COG0730	response to heat
M5J22_RS02655	COG1794	racemase activity, acting on amino acids and derivatives
M5J22_RS02670	COG3621	Patatin-like phospholipase
M5J22_RS02680	COG0662	Cupin 2, conserved barrel domain protein
M5J22_RS02695	COG0277	FAD linked oxidase domain protein
M5J22_RS02715	COG0662	Cupin 2, conserved barrel domain protein
M5J22_RS02720	COG2318	DinB family
M5J22_RS02750	COG1064	alcohol dehydrogenase
M5J22_RS02755	COG0789	Transcriptional regulator
M5J22_RS02765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5J22_RS02775	COG2814	Major facilitator Superfamily
M5J22_RS02780	COG1309	transcriptional regulator
M5J22_RS02785	COG5577	PFAM Coat F domain
M5J22_RS02795	COG1063	alcohol dehydrogenase
M5J22_RS02800	COG5577	PFAM Coat F domain
M5J22_RS02810	COG4585	Histidine kinase
M5J22_RS02815	COG2197	response regulator
M5J22_RS02820	COG2409	Drug exporters of the RND superfamily
M5J22_RS02825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M5J22_RS02830	COG0488	(ABC) transporter
M5J22_RS02835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5J22_RS02840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS02850	COG2814	Major facilitator Superfamily
M5J22_RS02855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5J22_RS02865	COG0730	response to heat
M5J22_RS02870	COG0456	acetyltransferase
M5J22_RS02875	COG0789	Transcriptional regulator
M5J22_RS02875	COG4978	Transcriptional regulator
M5J22_RS02880	COG0697	spore germination
M5J22_RS02885	COG1051	belongs to the nudix hydrolase family
M5J22_RS02890	COG0596	Alpha beta hydrolase
M5J22_RS02895	COG0473	3-isopropylmalate dehydrogenase activity
M5J22_RS02900	COG1802	Transcriptional regulator
M5J22_RS02905	COG1819	glycosyl
M5J22_RS02920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5J22_RS02930	COG1388	LysM domain
M5J22_RS02935	COG2814	Major facilitator Superfamily
M5J22_RS02940	COG2188	Transcriptional regulator
M5J22_RS02945	COG2186	Transcriptional regulator
M5J22_RS02950	COG2807	transmembrane transport
M5J22_RS02955	COG2076	Multidrug Resistance protein
M5J22_RS02960	COG2076	Multidrug Resistance protein
M5J22_RS02965	COG1309	transcriptional regulator
M5J22_RS02970	COG0531	amino acid
M5J22_RS02980	COG3832	glyoxalase III activity
M5J22_RS02985	COG0604	alcohol dehydrogenase
M5J22_RS02990	COG2814	Major facilitator Superfamily
M5J22_RS03030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5J22_RS03035	COG0802	atpase or kinase
M5J22_RS03040	COG1214	PFAM Peptidase M22, glycoprotease
M5J22_RS03045	COG0456	acetyltransferase
M5J22_RS03050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5J22_RS03055	COG0488	(ABC) transporter
M5J22_RS03070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5J22_RS03075	COG0805	protein transport
M5J22_RS03085	COG1266	CAAX protease self-immunity
M5J22_RS03115	COG0457	Tetratricopeptide repeat
M5J22_RS03120	COG1063	alcohol dehydrogenase
M5J22_RS03125	COG2211	Major facilitator Superfamily
M5J22_RS03130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5J22_RS03140	COG1842	Phage shock protein A
M5J22_RS03145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5J22_RS03150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M5J22_RS03155	COG4260	virion core protein, lumpy skin disease virus
M5J22_RS03160	COG2755	lipolytic protein G-D-S-L family
M5J22_RS03160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M5J22_RS03170	COG1595	DNA-templated transcription, initiation
M5J22_RS03175	COG1063	alcohol dehydrogenase
M5J22_RS03180	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5J22_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
M5J22_RS03200	COG2132	Multicopper oxidase
M5J22_RS03205	COG1113	amino acid transport
M5J22_RS03210	COG0714	Associated with various cellular activities
M5J22_RS03215	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M5J22_RS03220	COG1305	Transglutaminase-like
M5J22_RS03240	COG2252	PERMEase
M5J22_RS03245	COG3064	Membrane
M5J22_RS03265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5J22_RS03270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5J22_RS03275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5J22_RS03280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5J22_RS03285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5J22_RS03300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5J22_RS03310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5J22_RS03315	COG0138	bifunctional purine biosynthesis protein purh
M5J22_RS03320	COG0151	Belongs to the GarS family
M5J22_RS03330	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5J22_RS03335	COG1470	cell adhesion involved in biofilm formation
M5J22_RS03340	COG4496	protein, YerC YecD
M5J22_RS03345	COG0069	glutamate synthase activity
M5J22_RS03355	COG0210	DNA helicase
M5J22_RS03365	COG4851	CamS sex pheromone cAM373 precursor
M5J22_RS03370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5J22_RS03375	COG1285	pathogenesis
M5J22_RS03380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5J22_RS03400	COG1309	transcriptional regulator
M5J22_RS03405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5J22_RS03410	COG1597	lipid kinase activity
M5J22_RS03415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5J22_RS03425	COG1131	(ABC) transporter
M5J22_RS03450	COG5444	nuclease activity
M5J22_RS03485	COG3546	catalase activity
M5J22_RS03490	COG0454	-acetyltransferase
M5J22_RS03500	COG2323	membrane
M5J22_RS03505	COG2329	Antibiotic biosynthesis monooxygenase
M5J22_RS03510	COG0346	lactoylglutathione lyase activity
M5J22_RS03515	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS03520	COG5583	Uncharacterized small protein (DUF2292)
M5J22_RS03525	COG0196	riboflavin kinase activity
M5J22_RS03530	COG0670	Belongs to the BI1 family
M5J22_RS03540	COG1846	Transcriptional regulator
M5J22_RS03545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5J22_RS03555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5J22_RS03555	COG2124	cytochrome p450
M5J22_RS03560	COG1368	sulfuric ester hydrolase activity
M5J22_RS03565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5J22_RS03570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS03575	COG1442	glycosyl transferase family 8
M5J22_RS03580	COG1216	Glycosyl transferase, family 2
M5J22_RS03585	COG1442	glycosyl transferase family 8
M5J22_RS03590	COG2223	nitrite transmembrane transporter activity
M5J22_RS03595	COG0531	amino acid
M5J22_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS03605	COG0840	transmembrane signaling receptor activity
M5J22_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS03615	COG0457	Tetratricopeptide repeat
M5J22_RS03615	COG0463	Glycosyl transferase, family 2
M5J22_RS03620	COG0488	(ABC) transporter
M5J22_RS03625	COG0789	Transcriptional regulator
M5J22_RS03630	COG2814	Major facilitator Superfamily
M5J22_RS03635	COG0488	(ABC) transporter
M5J22_RS03640	COG0513	Belongs to the DEAD box helicase family
M5J22_RS03650	COG2130	NADP-dependent
M5J22_RS03665	COG3866	Pectate lyase
M5J22_RS03670	COG0471	metal ion transport
M5J22_RS03705	COG0745	RESPONSE REGULATOR receiver
M5J22_RS03705	COG2972	Histidine kinase
M5J22_RS03715	COG3279	Response regulator of the LytR AlgR family
M5J22_RS03725	COG3764	Sortase (surface protein transpeptidase)
M5J22_RS03730	COG3290	protein histidine kinase activity
M5J22_RS03735	COG4565	transcriptional regulatory protein
M5J22_RS03740	COG3181	Tripartite tricarboxylate transporter family receptor
M5J22_RS03745	COG2851	Citrate transporter
M5J22_RS03750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS03755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M5J22_RS03765	COG2258	MOSC domain
M5J22_RS03785	COG0024	Methionine aminopeptidase
M5J22_RS03790	COG1263	PTS System
M5J22_RS03790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS03800	COG1368	sulfuric ester hydrolase activity
M5J22_RS03810	COG0071	Belongs to the small heat shock protein (HSP20) family
M5J22_RS03825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS03825	COG1263	PTS System
M5J22_RS03830	COG0366	Alpha amylase catalytic
M5J22_RS03835	COG2188	Transcriptional regulator
M5J22_RS03840	COG0778	Nitroreductase
M5J22_RS03855	COG0737	Belongs to the 5'-nucleotidase family
M5J22_RS03860	COG0693	protein deglycase activity
M5J22_RS03865	COG1609	Transcriptional regulator
M5J22_RS03880	COG2814	Major facilitator Superfamily
M5J22_RS03890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5J22_RS03895	COG4980	gas vesicle protein
M5J22_RS03900	COG1295	ribonuclease BN
M5J22_RS03905	COG0477	Major facilitator Superfamily
M5J22_RS03910	COG0387	Pfam Sodium calcium exchanger
M5J22_RS03920	COG0668	transmembrane transport
M5J22_RS03925	COG0535	radical SAM domain protein
M5J22_RS03935	COG0726	polysaccharide deacetylase
M5J22_RS03940	COG2084	Dehydrogenase
M5J22_RS03950	COG0598	Magnesium transport protein CorA
M5J22_RS03955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5J22_RS03960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5J22_RS03970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5J22_RS03975	COG4637	Psort location Cytoplasmic, score
M5J22_RS03980	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5J22_RS03985	COG0022	dehydrogenase e1 component
M5J22_RS03990	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5J22_RS03995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5J22_RS04000	COG3284	Transcriptional regulator
M5J22_RS04010	COG1486	melibiose metabolic process
M5J22_RS04015	COG1737	Transcriptional regulator
M5J22_RS04020	COG1263	PTS System
M5J22_RS04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS04025	COG5434	Belongs to the glycosyl hydrolase 28 family
M5J22_RS04030	COG1132	(ABC) transporter
M5J22_RS04035	COG1132	(ABC) transporter
M5J22_RS04040	COG2259	Doxx family
M5J22_RS04045	COG2514	catechol 2,3-dioxygenase activity
M5J22_RS04055	COG1695	Transcriptional regulator
M5J22_RS04060	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5J22_RS04065	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M5J22_RS04070	COG0574	Belongs to the PEP-utilizing enzyme family
M5J22_RS04070	COG3848	Pyruvate phosphate dikinase
M5J22_RS04075	COG2732	(Barnase) inhibitor
M5J22_RS04080	COG2318	DinB family
M5J22_RS04085	COG2814	Major facilitator Superfamily
M5J22_RS04090	COG1846	Transcriptional regulator
M5J22_RS04095	COG0392	lysyltransferase activity
M5J22_RS04095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M5J22_RS04100	COG0384	phenazine biosynthesis protein PhzF
M5J22_RS04105	COG0778	Nitroreductase
M5J22_RS04120	COG1090	epimerase
M5J22_RS04135	COG2814	Major facilitator Superfamily
M5J22_RS04145	COG3591	Belongs to the peptidase S1B family
M5J22_RS04160	COG3103	Sh3 type 3 domain protein
M5J22_RS04165	COG5658	integral membrane protein
M5J22_RS04170	COG0596	Alpha beta hydrolase
M5J22_RS04175	COG0463	Glycosyl transferase, family 2
M5J22_RS04180	COG4485	Bacterial membrane protein, YfhO
M5J22_RS04185	COG1988	membrane-bound metal-dependent
M5J22_RS04190	COG1194	a g-specific adenine glycosylase
M5J22_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS04220	COG1132	(ABC) transporter
M5J22_RS04225	COG4129	membrane
M5J22_RS04235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5J22_RS04240	COG0735	belongs to the Fur family
M5J22_RS04355	COG3340	Belongs to the peptidase S51 family
M5J22_RS04365	COG0277	FAD linked oxidase domain protein
M5J22_RS04375	COG0747	negative chemotaxis
M5J22_RS04380	COG0601	transmembrane transport
M5J22_RS04385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5J22_RS04390	COG0444	Belongs to the ABC transporter superfamily
M5J22_RS04395	COG4608	Belongs to the ABC transporter superfamily
M5J22_RS04400	COG0753	catalase activity
M5J22_RS04410	COG1116	anion transmembrane transporter activity
M5J22_RS04415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5J22_RS04420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5J22_RS04440	COG1476	TRANSCRIPTIONal
M5J22_RS04450	COG3382	B3 4 domain protein
M5J22_RS04455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5J22_RS04465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5J22_RS04470	COG0789	Transcriptional regulator
M5J22_RS04475	COG1664	Polymer-forming cytoskeletal
M5J22_RS04480	COG1664	Polymer-forming cytoskeletal
M5J22_RS04485	COG2766	serine protein kinase
M5J22_RS04495	COG1846	Transcriptional regulator
M5J22_RS04500	COG1566	PFAM secretion protein HlyD family protein
M5J22_RS04505	COG2814	Major facilitator Superfamily
M5J22_RS04510	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5J22_RS04525	COG1725	Transcriptional regulator
M5J22_RS04530	COG1131	(ABC) transporter
M5J22_RS04535	COG1131	(ABC) transporter
M5J22_RS04540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5J22_RS04545	COG1278	Cold shock
M5J22_RS04550	COG1464	Belongs to the NlpA lipoprotein family
M5J22_RS04555	COG3706	GGDEF domain
M5J22_RS04560	COG1823	symporter activity
M5J22_RS04580	COG5577	PFAM Coat F domain
M5J22_RS04585	COG1525	nuclease
M5J22_RS04585	COG4085	toxin activity
M5J22_RS04585	COG0737	Belongs to the 5'-nucleotidase family
M5J22_RS04590	COG3764	Sortase (surface protein transpeptidase)
M5J22_RS04595	COG0564	pseudouridine synthase activity
M5J22_RS04605	COG0517	IMP dehydrogenase activity
M5J22_RS04610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5J22_RS04615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5J22_RS04615	COG3153	acetyltransferase
M5J22_RS04620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5J22_RS04625	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M5J22_RS04630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5J22_RS04640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5J22_RS04645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5J22_RS04650	COG4585	Histidine kinase
M5J22_RS04650	COG2203	Gaf domain
M5J22_RS04655	COG2197	response regulator
M5J22_RS04660	COG0431	NADPH-dependent FMN reductase
M5J22_RS04675	COG0791	NLP P60 protein
M5J22_RS04675	COG1388	LysM domain
M5J22_RS04680	COG1959	2 iron, 2 sulfur cluster binding
M5J22_RS04690	COG2719	SpoVR family
M5J22_RS04695	COG1785	Belongs to the alkaline phosphatase family
M5J22_RS04700	COG0791	NLP P60 protein
M5J22_RS04700	COG1388	LysM domain
M5J22_RS04705	COG0583	DNA-binding transcription factor activity
M5J22_RS04710	COG0372	Belongs to the citrate synthase family
M5J22_RS04715	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS04720	COG0531	amino acid
M5J22_RS04725	COG0733	neurotransmitter:sodium symporter activity
M5J22_RS04740	COG1595	DNA-templated transcription, initiation
M5J22_RS04745	COG0204	Acyl-transferase
M5J22_RS04750	COG1253	flavin adenine dinucleotide binding
M5J22_RS04755	COG0789	Transcriptional regulator
M5J22_RS04760	COG0436	Aminotransferase
M5J22_RS04765	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5J22_RS04770	COG1253	flavin adenine dinucleotide binding
M5J22_RS04775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5J22_RS04780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5J22_RS04785	COG0584	glycerophosphoryl diester phosphodiesterase
M5J22_RS04795	COG0668	transmembrane transport
M5J22_RS04800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5J22_RS04805	COG0726	polysaccharide deacetylase
M5J22_RS04810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS04815	COG3226	Transcriptional regulator
M5J22_RS04825	COG0589	response to stress
M5J22_RS04830	COG1132	(ABC) transporter
M5J22_RS04835	COG1132	(ABC) transporter
M5J22_RS04840	COG0702	epimerase
M5J22_RS04860	COG0189	ligase activity
M5J22_RS04865	COG0189	ligase activity
M5J22_RS04880	COG4335	DNA alkylation repair
M5J22_RS04885	COG0561	phosphatase activity
M5J22_RS04890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5J22_RS04900	COG0475	glutathione-regulated potassium exporter activity
M5J22_RS04905	COG0490	domain, Protein
M5J22_RS04915	COG1024	Enoyl-CoA hydratase
M5J22_RS04925	COG4152	abc transporter atp-binding protein
M5J22_RS04930	COG1668	transmembrane transport
M5J22_RS04935	COG0420	3'-5' exonuclease activity
M5J22_RS04940	COG4717	serine-type aminopeptidase activity
M5J22_RS04955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5J22_RS04990	COG4980	gas vesicle protein
M5J22_RS05005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5J22_RS05010	COG0537	adenosine 5'-monophosphoramidase activity
M5J22_RS05015	COG1131	(ABC) transporter
M5J22_RS05020	COG4473	ABC transporter
M5J22_RS05030	COG1473	amidohydrolase
M5J22_RS05035	COG3069	C4-dicarboxylate transmembrane transporter activity
M5J22_RS05040	COG2329	Antibiotic biosynthesis monooxygenase
M5J22_RS05045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5J22_RS05055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5J22_RS05060	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M5J22_RS05065	COG1309	transcriptional regulator
M5J22_RS05070	COG1511	domain protein
M5J22_RS05075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5J22_RS05085	COG1363	Peptidase, m42
M5J22_RS05090	COG1301	dicarboxylic acid transport
M5J22_RS05100	COG1234	tRNA 3'-trailer cleavage
M5J22_RS05105	COG0095	Lipoate-protein ligase
M5J22_RS05110	COG0702	epimerase
M5J22_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS05125	COG0501	Belongs to the peptidase M48B family
M5J22_RS05130	COG1404	Belongs to the peptidase S8 family
M5J22_RS05135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5J22_RS05140	COG0406	alpha-ribazole phosphatase activity
M5J22_RS05145	COG0183	Belongs to the thiolase family
M5J22_RS05150	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS05155	COG1268	BioY protein
M5J22_RS05160	COG0840	transmembrane signaling receptor activity
M5J22_RS05165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5J22_RS05165	COG0723	plastoquinol--plastocyanin reductase activity
M5J22_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS05180	COG4903	ComK protein
M5J22_RS05190	COG5646	InterPro IPR014922
M5J22_RS05210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5J22_RS05225	COG0398	Pfam SNARE associated Golgi protein
M5J22_RS05230	COG0681	Belongs to the peptidase S26 family
M5J22_RS05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5J22_RS05240	COG1846	Transcriptional regulator
M5J22_RS05245	COG3180	Ammonia monooxygenase
M5J22_RS05250	COG2814	Major facilitator Superfamily
M5J22_RS05260	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M5J22_RS05265	COG2323	membrane
M5J22_RS05280	COG0420	3'-5' exonuclease activity
M5J22_RS05285	COG0419	ATPase involved in DNA repair
M5J22_RS05290	COG1403	HNH endonuclease
M5J22_RS05330	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5J22_RS05350	COG0367	asparagine synthase
M5J22_RS05355	COG1562	ergosterol biosynthetic process
M5J22_RS05360	COG0534	Mate efflux family protein
M5J22_RS05365	COG1917	Cupin 2, conserved barrel domain protein
M5J22_RS05365	COG2207	Transcriptional regulator
M5J22_RS05370	COG1609	Transcriptional regulator
M5J22_RS05375	COG0673	inositol 2-dehydrogenase activity
M5J22_RS05380	COG2318	DinB family
M5J22_RS05385	COG1357	PFAM Pentapeptide repeats (8 copies)
M5J22_RS05390	COG2153	protein acetylation
M5J22_RS05395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5J22_RS05395	COG0646	methionine synthase
M5J22_RS05405	COG2996	Protein conserved in bacteria
M5J22_RS05410	COG1744	ABC transporter substrate-binding protein PnrA-like
M5J22_RS05415	COG0840	transmembrane signaling receptor activity
M5J22_RS05425	COG1307	EDD domain protein, DegV family
M5J22_RS05430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS05450	COG0561	phosphatase activity
M5J22_RS05455	COG1073	alpha beta
M5J22_RS05460	COG2151	metal-sulfur cluster biosynthetic enzyme
M5J22_RS05470	COG0277	FAD linked oxidase domain protein
M5J22_RS05475	COG2271	Major facilitator Superfamily
M5J22_RS05485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5J22_RS05495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5J22_RS05500	COG0505	Belongs to the CarA family
M5J22_RS05505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5J22_RS05510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5J22_RS05525	COG2267	carboxylic ester hydrolase activity
M5J22_RS05535	COG1744	ABC transporter substrate-binding protein PnrA-like
M5J22_RS05550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5J22_RS05555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5J22_RS05560	COG5504	Zn-dependent protease
M5J22_RS05565	COG0444	Belongs to the ABC transporter superfamily
M5J22_RS05570	COG4608	Belongs to the ABC transporter superfamily
M5J22_RS05580	COG0601	transmembrane transport
M5J22_RS05585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5J22_RS05605	COG0180	Tryptophanyl-tRNA synthetase
M5J22_RS05610	COG4166	transmembrane transport
M5J22_RS05615	COG0601	transmembrane transport
M5J22_RS05620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5J22_RS05625	COG0444	Belongs to the ABC transporter superfamily
M5J22_RS05630	COG4608	Belongs to the ABC transporter superfamily
M5J22_RS05640	COG0456	acetyltransferase
M5J22_RS05645	COG1393	Belongs to the ArsC family
M5J22_RS05650	COG0861	Integral membrane protein TerC family
M5J22_RS05660	COG4862	establishment of competence for transformation
M5J22_RS05665	COG4469	Competence protein
M5J22_RS05670	COG1164	Oligoendopeptidase f
M5J22_RS05680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5J22_RS05685	COG2346	COG2346, Truncated hemoglobins
M5J22_RS05690	COG0741	lytic transglycosylase activity
M5J22_RS05695	COG4116	CYTH
M5J22_RS05705	COG2357	RelA SpoT domain protein
M5J22_RS05710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5J22_RS05715	COG0564	pseudouridine synthase activity
M5J22_RS05725	COG0569	domain protein
M5J22_RS05725	COG0475	glutathione-regulated potassium exporter activity
M5J22_RS05730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5J22_RS05735	COG0352	thiamine-phosphate diphosphorylase activity
M5J22_RS05740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5J22_RS05745	COG2104	thiamine diphosphate biosynthetic process
M5J22_RS05755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5J22_RS05760	COG0351	phosphomethylpyrimidine kinase
M5J22_RS05765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5J22_RS05820	COG0210	DNA helicase
M5J22_RS05840	COG1131	(ABC) transporter
M5J22_RS05850	COG2153	protein acetylation
M5J22_RS05860	COG2382	esterase
M5J22_RS05865	COG0626	cystathionine gamma-synthase activity
M5J22_RS05870	COG0626	cystathionine gamma-synthase activity
M5J22_RS05880	COG0582	viral genome integration into host DNA
M5J22_RS05885	COG2856	Zn peptidase
M5J22_RS05895	COG3620	sequence-specific DNA binding
M5J22_RS05945	COG3935	DnaD domain protein
M5J22_RS05950	COG1484	DNA-dependent DNA replication
M5J22_RS05960	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M5J22_RS06000	COG1595	DNA-templated transcription, initiation
M5J22_RS06035	COG5484	DNA packaging
M5J22_RS06150	COG4824	toxin secretion phage lysis holin
M5J22_RS06165	COG5444	nuclease activity
M5J22_RS06195	COG5444	nuclease activity
M5J22_RS06205	COG0346	lactoylglutathione lyase activity
M5J22_RS06210	COG2367	Beta-lactamase
M5J22_RS06215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5J22_RS06225	COG1846	Transcriptional regulator
M5J22_RS06235	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M5J22_RS06240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5J22_RS06245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5J22_RS06250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS06250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS06255	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5J22_RS06265	COG1349	DNA-binding transcription factor activity
M5J22_RS06280	COG1285	pathogenesis
M5J22_RS06290	COG2205	protein histidine kinase activity
M5J22_RS06300	COG3383	formate dehydrogenase (NAD+) activity
M5J22_RS06305	COG2427	Protein of unknown function (DUF1641)
M5J22_RS06310	COG2124	cytochrome p450
M5J22_RS06315	COG1819	glycosyl
M5J22_RS06325	COG1587	Uroporphyrinogen-III synthase
M5J22_RS06330	COG0390	transport system, permease component
M5J22_RS06335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5J22_RS06340	COG0697	spore germination
M5J22_RS06345	COG4297	protein containing double-stranded beta helix domain
M5J22_RS06355	COG1252	NADH dehydrogenase
M5J22_RS06365	COG2211	Major facilitator Superfamily
M5J22_RS06370	COG1609	Transcriptional regulator
M5J22_RS06375	COG0246	Mannitol dehydrogenase
M5J22_RS06380	COG2721	sulfolactate sulfo-lyase activity
M5J22_RS06385	COG0745	RESPONSE REGULATOR receiver
M5J22_RS06390	COG2770	Histidine kinase
M5J22_RS06390	COG2205	protein histidine kinase activity
M5J22_RS06405	COG0730	response to heat
M5J22_RS06410	COG2318	DinB family
M5J22_RS06415	COG0457	Tetratricopeptide repeat
M5J22_RS06425	COG1388	LysM domain
M5J22_RS06425	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS06425	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS06435	COG4195	phage-related replication protein
M5J22_RS06445	COG2856	Zn peptidase
M5J22_RS06450	COG1396	sequence-specific DNA binding
M5J22_RS06460	COG1522	sequence-specific DNA binding
M5J22_RS06465	COG1484	DNA-dependent DNA replication
M5J22_RS06485	COG1595	DNA-templated transcription, initiation
M5J22_RS06490	COG3728	DNA packaging
M5J22_RS06490	COG5484	DNA packaging
M5J22_RS06495	COG1783	phage Terminase large subunit
M5J22_RS06500	COG5518	Phage portal protein
M5J22_RS06505	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5J22_RS06510	COG4653	Phage capsid family
M5J22_RS06560	COG5412	phage tail tape measure protein
M5J22_RS06560	COG5412	phage tail tape measure protein
M5J22_RS06560	COG3953	SLT domain
M5J22_RS06560	COG5412	phage tail tape measure protein
M5J22_RS06560	COG3953	SLT domain
M5J22_RS06560	COG3953	SLT domain
M5J22_RS06565	COG1652	LysM domain
M5J22_RS06570	COG4193	domain, Protein
M5J22_RS06580	COG3628	GPW Gp25 family protein
M5J22_RS06585	COG3299	homolog of phage Mu protein gp47
M5J22_RS06590	COG3778	Protein conserved in bacteria
M5J22_RS06630	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS06630	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS06650	COG0306	phosphate transporter
M5J22_RS06655	COG1392	Phosphate transport regulator
M5J22_RS06660	COG0531	amino acid
M5J22_RS06665	COG0346	lactoylglutathione lyase activity
M5J22_RS06670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M5J22_RS06675	COG0463	Glycosyl transferase, family 2
M5J22_RS06685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5J22_RS06690	COG0477	Major facilitator Superfamily
M5J22_RS06695	COG2362	D-Aminopeptidase
M5J22_RS06700	COG0601	transmembrane transport
M5J22_RS06705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5J22_RS06710	COG0444	Belongs to the ABC transporter superfamily
M5J22_RS06715	COG4166	transmembrane transport
M5J22_RS06720	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5J22_RS06725	COG4948	Mandelate Racemase Muconate Lactonizing
M5J22_RS06730	COG0791	NLP P60 protein
M5J22_RS06735	COG4608	Belongs to the ABC transporter superfamily
M5J22_RS06740	COG2706	6-phosphogluconolactonase activity
M5J22_RS06745	COG1834	amidinotransferase
M5J22_RS06750	COG1607	acyl-coa hydrolase
M5J22_RS06755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5J22_RS06760	COG2076	Multidrug Resistance protein
M5J22_RS06765	COG2076	Multidrug Resistance protein
M5J22_RS06770	COG0788	formyltetrahydrofolate deformylase activity
M5J22_RS06775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5J22_RS06790	COG1846	Transcriptional regulator
M5J22_RS06795	COG1764	response to oxidative stress
M5J22_RS06810	COG0463	Glycosyl transferase, family 2
M5J22_RS06810	COG0457	Tetratricopeptide repeat
M5J22_RS06820	COG2814	Major facilitator Superfamily
M5J22_RS06825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5J22_RS06835	COG1404	Belongs to the peptidase S8 family
M5J22_RS06840	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS06845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5J22_RS06850	COG1122	ATPase activity
M5J22_RS06855	COG4721	ABC-type cobalt transport system, permease component
M5J22_RS06860	COG1388	LysM domain
M5J22_RS06860	COG3858	chitin binding
M5J22_RS06870	COG2239	Acts as a magnesium transporter
M5J22_RS06875	COG0789	Transcriptional regulator
M5J22_RS06890	COG1846	Transcriptional regulator
M5J22_RS06895	COG0726	polysaccharide deacetylase
M5J22_RS06900	COG1793	dna ligase
M5J22_RS06900	COG3285	dna ligase
M5J22_RS06905	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M5J22_RS06910	COG0586	Pfam SNARE associated Golgi protein
M5J22_RS06920	COG1191	sigma factor activity
M5J22_RS06945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5J22_RS06950	COG2323	membrane
M5J22_RS06960	COG3594	Acyltransferase
M5J22_RS06965	COG5002	protein histidine kinase activity
M5J22_RS06970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5J22_RS06990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5J22_RS06995	COG0436	Aminotransferase
M5J22_RS07025	COG3852	Histidine kinase
M5J22_RS07030	COG1846	Transcriptional regulator
M5J22_RS07035	COG1360	Flagellar Motor Protein
M5J22_RS07040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5J22_RS07045	COG0542	response to heat
M5J22_RS07050	COG3949	Membrane
M5J22_RS07065	COG0720	synthase
M5J22_RS07070	COG0602	queuosine metabolic process
M5J22_RS07085	COG4873	Protein conserved in bacteria
M5J22_RS07095	COG3773	Cell wall hydrolase
M5J22_RS07100	COG2244	polysaccharide biosynthetic process
M5J22_RS07105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS07110	COG2217	Heavy metal translocating P-type atpase
M5J22_RS07115	COG0006	proline dipeptidase activity
M5J22_RS07120	COG1609	Transcriptional regulator
M5J22_RS07125	COG3711	transcriptional antiterminator
M5J22_RS07130	COG1263	PTS System
M5J22_RS07130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS07130	COG2190	(PTS) system
M5J22_RS07135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS07140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5J22_RS07150	COG1533	DNA photolyase activity
M5J22_RS07155	COG0840	transmembrane signaling receptor activity
M5J22_RS07160	COG2084	Dehydrogenase
M5J22_RS07165	COG2340	Cysteine-rich secretory protein family
M5J22_RS07170	COG0768	penicillin binding
M5J22_RS07180	COG0436	Aminotransferase
M5J22_RS07190	COG0784	Response regulator, receiver
M5J22_RS07190	COG0835	chemotaxis
M5J22_RS07200	COG2814	Major facilitator Superfamily
M5J22_RS07205	COG1376	ErfK ybiS ycfS ynhG family protein
M5J22_RS07210	COG1408	metallophosphoesterase
M5J22_RS07215	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS07225	COG2200	EAL domain
M5J22_RS07230	COG4703	Protein of unknown function (DUF1797)
M5J22_RS07235	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M5J22_RS07245	COG0517	IMP dehydrogenase activity
M5J22_RS07250	COG0583	DNA-binding transcription factor activity
M5J22_RS07255	COG0716	FMN binding
M5J22_RS07265	COG0716	FMN binding
M5J22_RS07285	COG0668	transmembrane transport
M5J22_RS07290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS07310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5J22_RS07315	COG0303	'Molybdopterin
M5J22_RS07320	COG1763	Mo-molybdopterin cofactor biosynthetic process
M5J22_RS07325	COG0314	molybdopterin synthase activity
M5J22_RS07330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5J22_RS07340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5J22_RS07345	COG1136	(ABC) transporter
M5J22_RS07350	COG0577	efflux transmembrane transporter activity
M5J22_RS07355	COG1349	DNA-binding transcription factor activity
M5J22_RS07360	COG1105	Belongs to the carbohydrate kinase PfkB family
M5J22_RS07365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5J22_RS07365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5J22_RS07365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS07370	COG0681	Belongs to the peptidase S26 family
M5J22_RS07380	COG0488	(ABC) transporter
M5J22_RS07385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5J22_RS07390	COG2309	aminopeptidase activity
M5J22_RS07400	COG1077	Cell shape determining protein MreB Mrl
M5J22_RS07405	COG2002	toxin-antitoxin pair type II binding
M5J22_RS07410	COG3852	Histidine kinase
M5J22_RS07415	COG2105	PFAM AIG2 family protein
M5J22_RS07415	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M5J22_RS07420	COG0569	domain protein
M5J22_RS07430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5J22_RS07440	COG0561	phosphatase activity
M5J22_RS07445	COG0242	peptide deformylase activity
M5J22_RS07455	COG0497	DNA recombination
M5J22_RS07465	COG3321	synthase
M5J22_RS07465	COG4221	oxidoreductase activity
M5J22_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS07465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS07470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS07470	COG0300	oxidoreductase activity
M5J22_RS07470	COG4221	oxidoreductase activity
M5J22_RS07470	COG3321	synthase
M5J22_RS07475	COG3321	synthase
M5J22_RS07475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS07475	COG4221	oxidoreductase activity
M5J22_RS07480	COG0300	oxidoreductase activity
M5J22_RS07480	COG3321	synthase
M5J22_RS07480	COG4221	oxidoreductase activity
M5J22_RS07480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS07485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS07485	COG0300	oxidoreductase activity
M5J22_RS07485	COG3321	synthase
M5J22_RS07485	COG4221	oxidoreductase activity
M5J22_RS07490	COG0300	oxidoreductase activity
M5J22_RS07490	COG3321	synthase
M5J22_RS07490	COG4221	oxidoreductase activity
M5J22_RS07490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS07495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS07495	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS07495	COG3321	synthase
M5J22_RS07495	COG4221	oxidoreductase activity
M5J22_RS07500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5J22_RS07505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5J22_RS07510	COG0022	dehydrogenase e1 component
M5J22_RS07515	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5J22_RS07520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5J22_RS07525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS07540	COG1982	Orn Lys Arg decarboxylase major
M5J22_RS07560	COG0483	inositol monophosphate 1-phosphatase activity
M5J22_RS07570	COG3227	Zinc metalloprotease (Elastase)
M5J22_RS07575	COG1595	DNA-templated transcription, initiation
M5J22_RS07595	COG1217	gtp-binding protein TYPA
M5J22_RS07605	COG4896	Protein conserved in bacteria
M5J22_RS07615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5J22_RS07620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M5J22_RS07625	COG2066	Belongs to the glutaminase family
M5J22_RS07635	COG0772	Belongs to the SEDS family
M5J22_RS07640	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M5J22_RS07655	COG2010	Cytochrome c
M5J22_RS07655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5J22_RS07660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5J22_RS07665	COG1845	cytochrome c oxidase, subunit III
M5J22_RS07670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5J22_RS07675	COG3336	cytochrome c oxidase
M5J22_RS07685	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M5J22_RS07690	COG2340	Cysteine-rich secretory protein family
M5J22_RS07705	COG3679	Belongs to the UPF0342 family
M5J22_RS07720	COG0742	ribosomal rna small subunit methyltransferase
M5J22_RS07730	COG3314	Sporulation integral membrane protein YlbJ
M5J22_RS07735	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5J22_RS07740	COG3480	Lon protease (S16) C-terminal proteolytic domain
M5J22_RS07750	COG1399	metal-binding, possibly nucleic acid-binding protein
M5J22_RS07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5J22_RS07790	COG4839	cell division protein FtsL
M5J22_RS07795	COG0768	penicillin binding
M5J22_RS07800	COG0768	penicillin binding
M5J22_RS07820	COG0772	Belongs to the SEDS family
M5J22_RS07835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5J22_RS07840	COG0849	cell division
M5J22_RS07845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5J22_RS07860	COG1191	sigma factor activity
M5J22_RS07870	COG1119	ATPase activity
M5J22_RS07875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5J22_RS07880	COG1873	PFAM PRC-barrel domain
M5J22_RS07885	COG1496	oxidoreductase activity
M5J22_RS07890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5J22_RS07900	COG0762	integral membrane protein
M5J22_RS07905	COG2302	S4 RNA-binding domain
M5J22_RS07910	COG3599	regulation of cell shape
M5J22_RS07915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5J22_RS07920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5J22_RS07940	COG2233	PERMEase
M5J22_RS07950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M5J22_RS07955	COG0505	Belongs to the CarA family
M5J22_RS07960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5J22_RS07975	COG0284	orotidine-5'-phosphate decarboxylase activity
M5J22_RS07980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5J22_RS07990	COG0306	phosphate transporter
M5J22_RS08005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5J22_RS08010	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M5J22_RS08015	COG1648	precorrin-2 dehydrogenase activity
M5J22_RS08025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M5J22_RS08030	COG1561	YicC-like family, N-terminal region
M5J22_RS08040	COG0194	GDP metabolic process
M5J22_RS08050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5J22_RS08055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5J22_RS08060	COG0242	peptide deformylase activity
M5J22_RS08070	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5J22_RS08070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5J22_RS08080	COG0631	protein serine/threonine phosphatase activity
M5J22_RS08085	COG2815	serine threonine protein kinase
M5J22_RS08085	COG0515	serine threonine protein kinase
M5J22_RS08095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5J22_RS08100	COG1564	THIamine pyrophosphokinase
M5J22_RS08115	COG1302	Protein conserved in bacteria
M5J22_RS08120	COG1461	Dihydroxyacetone kinase
M5J22_RS08125	COG1760	l-serine dehydratase
M5J22_RS08130	COG1760	l-serine dehydratase
M5J22_RS08135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5J22_RS08150	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5J22_RS08155	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS08170	COG1196	nuclear chromosome segregation
M5J22_RS08175	COG0552	protein localization to endoplasmic reticulum
M5J22_RS08190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5J22_RS08200	COG1837	Belongs to the UPF0109 family
M5J22_RS08225	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5J22_RS08240	COG2257	FlhB HrpN YscU SpaS Family
M5J22_RS08250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5J22_RS08255	COG0758	DNA mediated transformation
M5J22_RS08260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5J22_RS08270	COG4974	Belongs to the 'phage' integrase family
M5J22_RS08290	COG1815	bacterial-type flagellum-dependent cell motility
M5J22_RS08295	COG1558	bacterial-type flagellum-dependent cell motility
M5J22_RS08300	COG1677	Flagellar hook-basal body complex protein FliE
M5J22_RS08305	COG1766	The M ring may be actively involved in energy transduction
M5J22_RS08310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5J22_RS08315	COG1317	bacterial-type flagellum organization
M5J22_RS08320	COG1157	protein secretion by the type III secretion system
M5J22_RS08325	COG2882	bacterial-type flagellum organization
M5J22_RS08330	COG3334	PFAM MgtE intracellular
M5J22_RS08335	COG3144	bacterial-type flagellum assembly
M5J22_RS08340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5J22_RS08345	COG4786	Flagellar basal body rod
M5J22_RS08350	COG1582	Flagellar protein (FlbD)
M5J22_RS08355	COG1580	Controls the rotational direction of flagella during chemotaxis
M5J22_RS08360	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5J22_RS08365	COG1776	CheC inhibitor of MCP methylation
M5J22_RS08365	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5J22_RS08370	COG2201	protein-glutamate methylesterase activity
M5J22_RS08375	COG3190	flagellar
M5J22_RS08380	COG1338	Plays a role in the flagellum-specific transport system
M5J22_RS08385	COG1987	bacterial-type flagellum assembly
M5J22_RS08390	COG1684	flagellar biosynthetic protein fliR
M5J22_RS08395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5J22_RS08400	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5J22_RS08405	COG1419	protein localization to endoplasmic reticulum
M5J22_RS08410	COG0455	bacterial-type flagellum organization
M5J22_RS08415	COG2201	protein-glutamate methylesterase activity
M5J22_RS08420	COG0643	Histidine kinase
M5J22_RS08420	COG2198	Histidine kinase
M5J22_RS08425	COG0835	chemotaxis
M5J22_RS08430	COG1776	CheC inhibitor of MCP methylation
M5J22_RS08440	COG1191	sigma factor activity
M5J22_RS08470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5J22_RS08475	COG4589	Belongs to the CDS family
M5J22_RS08485	COG0750	zinc metalloprotease
M5J22_RS08505	COG0195	Participates in both transcription termination and antitermination
M5J22_RS08510	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M5J22_RS08515	COG1358	cellular component organization or biogenesis
M5J22_RS08525	COG1550	Protein conserved in bacteria
M5J22_RS08540	COG0196	riboflavin kinase activity
M5J22_RS08555	COG0726	polysaccharide deacetylase
M5J22_RS08560	COG0612	Peptidase, M16
M5J22_RS08565	COG1873	PFAM PRC-barrel domain
M5J22_RS08570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5J22_RS08575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5J22_RS08580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5J22_RS08585	COG0527	aspartate kinase activity
M5J22_RS08595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5J22_RS08600	COG0740	serine-type endopeptidase activity
M5J22_RS08610	COG1674	ftsk spoiiie
M5J22_RS08610	COG4980	gas vesicle protein
M5J22_RS08615	COG2188	Transcriptional regulator
M5J22_RS08620	COG2814	Major facilitator Superfamily
M5J22_RS08625	COG1846	Transcriptional regulator
M5J22_RS08630	COG2409	Drug exporters of the RND superfamily
M5J22_RS08630	COG1033	growth of symbiont in host cell
M5J22_RS08635	COG0612	Peptidase, M16
M5J22_RS08640	COG0612	Peptidase, M16
M5J22_RS08645	COG0300	oxidoreductase activity
M5J22_RS08660	COG1426	Protein conserved in bacteria
M5J22_RS08665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5J22_RS08680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5J22_RS08690	COG1692	metallophosphoesterase
M5J22_RS08695	COG2359	stage V sporulation protein S
M5J22_RS08715	COG4550	Control of competence regulator ComK, YlbF/YmcA
M5J22_RS08775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS08780	COG3425	synthase
M5J22_RS08785	COG1024	Enoyl-CoA hydratase
M5J22_RS08790	COG1024	Enoyl-CoA hydratase
M5J22_RS08795	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS08795	COG0300	oxidoreductase activity
M5J22_RS08795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS08795	COG3321	synthase
M5J22_RS08795	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS08800	COG4221	oxidoreductase activity
M5J22_RS08800	COG3321	synthase
M5J22_RS08800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS08800	COG0300	oxidoreductase activity
M5J22_RS08805	COG3321	synthase
M5J22_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS08805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS08805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS08805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS08805	COG3321	synthase
M5J22_RS08805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS08805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS08805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS08810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS08810	COG3321	synthase
M5J22_RS08810	COG4221	oxidoreductase activity
M5J22_RS08815	COG3321	synthase
M5J22_RS08815	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M5J22_RS08815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS08815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5J22_RS08820	COG2124	cytochrome p450
M5J22_RS08825	COG3209	COG3209 Rhs family protein
M5J22_RS08830	COG3619	membrane
M5J22_RS08840	COG1404	Belongs to the peptidase S8 family
M5J22_RS08850	COG4195	phage-related replication protein
M5J22_RS08855	COG1764	response to oxidative stress
M5J22_RS08865	COG2076	Multidrug Resistance protein
M5J22_RS08905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5J22_RS08910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5J22_RS08915	COG4112	unkown
M5J22_RS08920	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS08925	COG0464	growth
M5J22_RS08930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5J22_RS08935	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M5J22_RS08940	COG0789	Transcriptional regulator
M5J22_RS08945	COG0174	glutamine synthetase
M5J22_RS08955	COG2211	Major facilitator Superfamily
M5J22_RS08960	COG3507	Belongs to the glycosyl hydrolase 43 family
M5J22_RS08975	COG1070	Carbohydrate kinase
M5J22_RS09000	COG1064	alcohol dehydrogenase
M5J22_RS09030	COG3397	chitin binding
M5J22_RS09040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5J22_RS09055	COG5434	Belongs to the glycosyl hydrolase 28 family
M5J22_RS09060	COG0756	dUTP diphosphatase activity
M5J22_RS09065	COG4195	phage-related replication protein
M5J22_RS09100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M5J22_RS09110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5J22_RS09130	COG0785	Cytochrome C biogenesis protein
M5J22_RS09135	COG2201	protein-glutamate methylesterase activity
M5J22_RS09140	COG4846	Membrane protein involved in cytochrome C biogenesis
M5J22_RS09150	COG0071	Belongs to the small heat shock protein (HSP20) family
M5J22_RS09165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5J22_RS09170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS09190	COG0824	Thioesterase
M5J22_RS09200	COG4841	protein insertion into membrane
M5J22_RS09210	COG1832	CoA-binding protein
M5J22_RS09215	COG0187	DNA topoisomerase II activity
M5J22_RS09220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5J22_RS09230	COG1115	amino acid carrier protein
M5J22_RS09240	COG1063	alcohol dehydrogenase
M5J22_RS09245	COG0800	Aldolase
M5J22_RS09250	COG1312	Catalyzes the dehydration of D-mannonate
M5J22_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS09260	COG1609	Transcriptional regulator
M5J22_RS09265	COG2271	Major facilitator Superfamily
M5J22_RS09300	COG2205	protein histidine kinase activity
M5J22_RS09305	COG0745	RESPONSE REGULATOR receiver
M5J22_RS09315	COG3507	Belongs to the glycosyl hydrolase 43 family
M5J22_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS09345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5J22_RS09350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5J22_RS09355	COG2610	gluconate transmembrane transporter activity
M5J22_RS09360	COG2124	cytochrome p450
M5J22_RS09380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5J22_RS09390	COG2246	polysaccharide biosynthetic process
M5J22_RS09395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5J22_RS09400	COG0586	Pfam SNARE associated Golgi protein
M5J22_RS09405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5J22_RS09410	COG1024	Enoyl-CoA hydratase
M5J22_RS09415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5J22_RS09420	COG0511	ligase activity, forming carbon-carbon bonds
M5J22_RS09425	COG0439	Biotin carboxylase
M5J22_RS09430	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS09435	COG1960	acyl-CoA dehydrogenase activity
M5J22_RS09440	COG1649	PFAM Uncharacterised BCR, COG1649
M5J22_RS09450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M5J22_RS09450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS09455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS09465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS09470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS09475	COG2027	D-alanyl-D-alanine carboxypeptidase
M5J22_RS09480	COG2017	converts alpha-aldose to the beta-anomer
M5J22_RS09485	COG0534	Mate efflux family protein
M5J22_RS09515	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS09515	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS09520	COG4824	toxin secretion phage lysis holin
M5J22_RS09540	COG5434	Belongs to the glycosyl hydrolase 28 family
M5J22_RS09545	COG1388	LysM domain
M5J22_RS09545	COG1705	Flagellar rod assembly protein muramidase FlgJ
M5J22_RS09620	COG4626	Terminase
M5J22_RS09620	COG1802	Transcriptional regulator
M5J22_RS09660	COG0582	viral genome integration into host DNA
M5J22_RS09665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M5J22_RS09675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5J22_RS09750	COG0582	viral genome integration into host DNA
M5J22_RS09755	COG0166	Belongs to the GPI family
M5J22_RS09760	COG0405	Gamma-glutamyltransferase
M5J22_RS09765	COG2814	Major facilitator Superfamily
M5J22_RS09770	COG0640	Transcriptional regulator
M5J22_RS09785	COG0604	alcohol dehydrogenase
M5J22_RS09790	COG0493	'glutamate synthase
M5J22_RS09795	COG0067	glutamate synthase
M5J22_RS09795	COG0070	glutamate synthase
M5J22_RS09795	COG0069	glutamate synthase activity
M5J22_RS09800	COG0583	DNA-binding transcription factor activity
M5J22_RS09805	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5J22_RS09820	COG0300	oxidoreductase activity
M5J22_RS09825	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M5J22_RS09835	COG2814	Major facilitator Superfamily
M5J22_RS09840	COG1070	Carbohydrate kinase
M5J22_RS09845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5J22_RS09850	COG0243	molybdopterin cofactor binding
M5J22_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS09875	COG1733	regulation of RNA biosynthetic process
M5J22_RS09880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5J22_RS09885	COG0662	Cupin 2, conserved barrel domain protein
M5J22_RS09885	COG2207	Transcriptional regulator
M5J22_RS09890	COG1309	transcriptional regulator
M5J22_RS09895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS09905	COG0640	Transcriptional regulator
M5J22_RS09910	COG0741	lytic transglycosylase activity
M5J22_RS09915	COG2322	membrane
M5J22_RS09930	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5J22_RS09940	COG1388	LysM domain
M5J22_RS09940	COG3584	3D domain protein
M5J22_RS09945	COG0514	ATP-dependent DNA helicase (RecQ)
M5J22_RS09955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5J22_RS09960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5J22_RS09975	COG0071	Belongs to the small heat shock protein (HSP20) family
M5J22_RS10005	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS10010	COG1657	PFAM Prenyltransferase squalene oxidase
M5J22_RS10015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5J22_RS10020	COG0733	neurotransmitter:sodium symporter activity
M5J22_RS10025	COG0385	Bile acid
M5J22_RS10030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS10035	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5J22_RS10045	COG4548	von Willebrand factor, type A
M5J22_RS10050	COG0714	Associated with various cellular activities
M5J22_RS10055	COG2032	superoxide dismutase activity
M5J22_RS10060	COG1388	LysM domain
M5J22_RS10060	COG0791	NLP P60 protein
M5J22_RS10065	COG1819	glycosyl
M5J22_RS10070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5J22_RS10075	COG0534	Mate efflux family protein
M5J22_RS10080	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS10085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5J22_RS10090	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5J22_RS10100	COG2962	Rard protein
M5J22_RS10115	COG1942	4-Oxalocrotonate Tautomerase
M5J22_RS10125	COG1733	regulation of RNA biosynthetic process
M5J22_RS10130	COG0778	Nitroreductase
M5J22_RS10135	COG0400	carboxylic ester hydrolase activity
M5J22_RS10140	COG0346	lactoylglutathione lyase activity
M5J22_RS10150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5J22_RS10160	COG2723	6-phospho-beta-galactosidase activity
M5J22_RS10165	COG2188	Transcriptional regulator
M5J22_RS10170	COG0793	Belongs to the peptidase S41A family
M5J22_RS10170	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS10175	COG2226	methyltransferase
M5J22_RS10185	COG1876	peptidase activity
M5J22_RS10205	COG0671	phosphoesterase, PA-phosphatase related
M5J22_RS10240	COG1509	lysine 2,3-aminomutase activity
M5J22_RS10245	COG0456	acetyltransferase
M5J22_RS10250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5J22_RS10255	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5J22_RS10260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5J22_RS10265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5J22_RS10270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M5J22_RS10280	COG0456	acetyltransferase
M5J22_RS10285	COG0463	Glycosyl transferase, family 2
M5J22_RS10300	COG4641	Protein conserved in bacteria
M5J22_RS10310	COG1086	Polysaccharide biosynthesis protein
M5J22_RS10355	COG1388	LysM domain
M5J22_RS10360	COG0457	Tetratricopeptide repeat
M5J22_RS10415	COG5444	nuclease activity
M5J22_RS10455	COG1846	Transcriptional regulator
M5J22_RS10460	COG4698	Protein conserved in bacteria
M5J22_RS10465	COG2755	lipolytic protein G-D-S-L family
M5J22_RS10470	COG1999	signal sequence binding
M5J22_RS10480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5J22_RS10485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5J22_RS10490	COG1272	protein, Hemolysin III
M5J22_RS10495	COG0204	Acyl-transferase
M5J22_RS10500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5J22_RS10515	COG2521	methyltransferase
M5J22_RS10515	COG2136	Putative SAM-dependent methyltransferase
M5J22_RS10530	COG1413	lyase activity
M5J22_RS10535	COG1418	mRNA catabolic process
M5J22_RS10540	COG0386	Belongs to the glutathione peroxidase family
M5J22_RS10550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5J22_RS10560	COG1278	Cold shock
M5J22_RS10580	COG0328	RNA-DNA hybrid ribonuclease activity
M5J22_RS10585	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5J22_RS10590	COG0328	RNA-DNA hybrid ribonuclease activity
M5J22_RS10600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5J22_RS10615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5J22_RS10625	COG1755	Isoprenylcysteine carboxyl methyltransferase
M5J22_RS10630	COG3424	synthase
M5J22_RS10655	COG1335	isochorismatase
M5J22_RS10665	COG2233	PERMEase
M5J22_RS10675	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5J22_RS10680	COG1199	ATP-dependent helicase activity
M5J22_RS10695	COG0116	Belongs to the methyltransferase superfamily
M5J22_RS10725	COG3359	exonuclease
M5J22_RS10730	COG1111	helicase
M5J22_RS10730	COG1205	dead DEAH box helicase
M5J22_RS10735	COG2190	(PTS) system
M5J22_RS10740	COG0071	Belongs to the small heat shock protein (HSP20) family
M5J22_RS10780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5J22_RS10780	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5J22_RS10790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5J22_RS10795	COG3935	DnaD domain protein
M5J22_RS10805	COG0436	Aminotransferase
M5J22_RS10810	COG5353	protein conserved in bacteria
M5J22_RS10820	COG1199	ATP-dependent helicase activity
M5J22_RS10820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5J22_RS10850	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS10855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5J22_RS10870	COG1694	Mazg nucleotide pyrophosphohydrolase
M5J22_RS10875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS10880	COG2140	Oxalate decarboxylase
M5J22_RS10890	COG4347	Protein of unknown function (DUF1405)
M5J22_RS10895	COG2010	Cytochrome c
M5J22_RS10895	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5J22_RS10900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5J22_RS10905	COG0723	plastoquinol--plastocyanin reductase activity
M5J22_RS10920	COG0457	Tetratricopeptide repeat
M5J22_RS10930	COG0287	Prephenate dehydrogenase
M5J22_RS10965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5J22_RS10970	COG4401	Chorismate mutase type I
M5J22_RS10985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5J22_RS10990	COG0105	UTP biosynthetic process
M5J22_RS10995	COG0142	geranyltranstransferase activity
M5J22_RS11005	COG0142	geranyltranstransferase activity
M5J22_RS11020	COG0776	regulation of translation
M5J22_RS11025	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5J22_RS11065	COG0539	negative regulation of cytoplasmic translation
M5J22_RS11080	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M5J22_RS11085	COG2959	enzyme of heme biosynthesis
M5J22_RS11090	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS11090	COG3773	Cell wall hydrolase
M5J22_RS11095	COG2339	peptidase activity
M5J22_RS11100	COG0492	ferredoxin-NADP+ reductase activity
M5J22_RS11105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5J22_RS11110	COG4862	establishment of competence for transformation
M5J22_RS11115	COG1408	metallophosphoesterase
M5J22_RS11125	COG1388	LysM domain
M5J22_RS11130	COG1266	CAAX protease self-immunity
M5J22_RS11135	COG0514	ATP-dependent DNA helicase (RecQ)
M5J22_RS11140	COG4955	Helix-turn-helix domain
M5J22_RS11145	COG1141	Ferredoxin
M5J22_RS11150	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M5J22_RS11155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5J22_RS11165	COG1595	DNA-templated transcription, initiation
M5J22_RS11170	COG5002	protein histidine kinase activity
M5J22_RS11175	COG0745	RESPONSE REGULATOR receiver
M5J22_RS11180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5J22_RS11185	COG1333	cytochrome c biogenesis protein
M5J22_RS11190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS11195	COG1187	pseudouridine synthase activity
M5J22_RS11200	COG0700	Nucleoside recognition
M5J22_RS11205	COG2715	membrane protein required for spore maturation
M5J22_RS11210	COG1686	Belongs to the peptidase S11 family
M5J22_RS11235	COG1547	Domain of unknown function (DUF309)
M5J22_RS11240	COG0456	acetyltransferase
M5J22_RS11255	COG0307	riboflavin synthase, alpha
M5J22_RS11260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5J22_RS11260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5J22_RS11270	COG0681	Belongs to the peptidase S26 family
M5J22_RS11280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5J22_RS11285	COG4086	secreted protein
M5J22_RS11290	COG0019	diaminopimelate decarboxylase activity
M5J22_RS11295	COG0697	spore germination
M5J22_RS11310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5J22_RS11330	COG1191	sigma factor activity
M5J22_RS11340	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS11345	COG1686	Belongs to the peptidase S11 family
M5J22_RS11350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5J22_RS11355	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5J22_RS11360	COG4974	Belongs to the 'phage' integrase family
M5J22_RS11370	COG0735	belongs to the Fur family
M5J22_RS11375	COG1300	Membrane
M5J22_RS11390	COG0281	malic enzyme
M5J22_RS11395	COG1757	Na H antiporter
M5J22_RS11400	COG1027	Aspartate ammonia-lyase
M5J22_RS11405	COG0252	asparaginase activity
M5J22_RS11410	COG1396	sequence-specific DNA binding
M5J22_RS11415	COG1379	DNA repair
M5J22_RS11420	COG0494	nUDIX hydrolase
M5J22_RS11430	COG0667	Aldo Keto reductase
M5J22_RS11440	COG1073	alpha beta
M5J22_RS11450	COG4918	Iron-sulphur cluster biosynthesis
M5J22_RS11455	COG0456	acetyltransferase
M5J22_RS11455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M5J22_RS11460	COG2329	Antibiotic biosynthesis monooxygenase
M5J22_RS11465	COG0456	acetyltransferase
M5J22_RS11470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5J22_RS11485	COG0628	permease
M5J22_RS11495	COG0346	lactoylglutathione lyase activity
M5J22_RS11505	COG3048	D-serine ammonia-lyase activity
M5J22_RS11510	COG0300	oxidoreductase activity
M5J22_RS11515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS11520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5J22_RS11525	COG1024	Enoyl-CoA hydratase
M5J22_RS11530	COG3425	synthase
M5J22_RS11535	COG2124	cytochrome p450
M5J22_RS11540	COG3321	synthase
M5J22_RS11540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS11540	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS11540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS11545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS11545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11545	COG3321	synthase
M5J22_RS11550	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11550	COG3321	synthase
M5J22_RS11550	COG0300	oxidoreductase activity
M5J22_RS11550	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS11550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11555	COG3321	synthase
M5J22_RS11555	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11555	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS11555	COG0300	oxidoreductase activity
M5J22_RS11560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5J22_RS11560	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11560	COG3321	synthase
M5J22_RS11560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5J22_RS11560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11565	COG0300	oxidoreductase activity
M5J22_RS11565	COG3321	synthase
M5J22_RS11565	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS11565	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS11575	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS11580	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS11595	COG2070	2-Nitropropane dioxygenase
M5J22_RS11595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5J22_RS11600	COG0250	Participates in transcription elongation, termination and antitermination
M5J22_RS11620	COG0596	Alpha beta hydrolase
M5J22_RS11635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5J22_RS11640	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5J22_RS11655	COG0706	membrane insertase activity
M5J22_RS11660	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5J22_RS11665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5J22_RS11670	COG0346	lactoylglutathione lyase activity
M5J22_RS11680	COG1376	ErfK ybiS ycfS ynhG family protein
M5J22_RS11685	COG4129	membrane
M5J22_RS11690	COG1126	abc transporter atp-binding protein
M5J22_RS11695	COG0765	amino acid transport
M5J22_RS11700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS11710	COG1597	lipid kinase activity
M5J22_RS11715	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5J22_RS11720	COG0022	dehydrogenase e1 component
M5J22_RS11725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5J22_RS11730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5J22_RS11735	COG3426	butyrate kinase activity
M5J22_RS11740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5J22_RS11745	COG0280	phosphate acetyltransferase
M5J22_RS11750	COG3290	protein histidine kinase activity
M5J22_RS11750	COG3829	transcription factor binding
M5J22_RS11760	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5J22_RS11765	COG2079	MmgE PrpD family protein
M5J22_RS11770	COG0372	Belongs to the citrate synthase family
M5J22_RS11775	COG1960	acyl-CoA dehydrogenase activity
M5J22_RS11780	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5J22_RS11785	COG0183	Belongs to the thiolase family
M5J22_RS11790	COG0584	glycerophosphoryl diester phosphodiesterase
M5J22_RS11795	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS11820	COG1902	pentaerythritol trinitrate reductase activity
M5J22_RS11835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5J22_RS11840	COG0745	RESPONSE REGULATOR receiver
M5J22_RS11845	COG0750	zinc metalloprotease
M5J22_RS11850	COG0497	DNA recombination
M5J22_RS11860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M5J22_RS11870	COG0142	geranyltranstransferase activity
M5J22_RS11880	COG1570	exodeoxyribonuclease VII activity
M5J22_RS11895	COG1302	Protein conserved in bacteria
M5J22_RS11900	COG0439	Biotin carboxylase
M5J22_RS11905	COG0511	ligase activity, forming carbon-carbon bonds
M5J22_RS11945	COG3854	ATPases associated with a variety of cellular activities
M5J22_RS11960	COG0006	proline dipeptidase activity
M5J22_RS11970	COG3872	metal-dependent enzyme
M5J22_RS11980	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5J22_RS11995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5J22_RS12015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5J22_RS12030	COG1396	sequence-specific DNA binding
M5J22_RS12040	COG0681	Belongs to the peptidase S26 family
M5J22_RS12065	COG4940	Competence protein ComGF
M5J22_RS12075	COG4970	Tfp pilus assembly protein FimT
M5J22_RS12080	COG4537	Required for transformation and DNA binding
M5J22_RS12085	COG1459	type II secretion system
M5J22_RS12090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5J22_RS12095	COG0598	Magnesium transport protein CorA
M5J22_RS12100	COG1253	flavin adenine dinucleotide binding
M5J22_RS12105	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS12115	COG1393	Belongs to the ArsC family
M5J22_RS12125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS12135	COG0011	TIGRFAM Protein of
M5J22_RS12145	COG2866	Carboxypeptidase
M5J22_RS12150	COG1940	carbohydrate kinase activity
M5J22_RS12155	COG4483	Protein conserved in bacteria
M5J22_RS12160	COG1757	Na H antiporter
M5J22_RS12170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5J22_RS12185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5J22_RS12190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5J22_RS12195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5J22_RS12200	COG0581	inorganic phosphate transmembrane transporter activity
M5J22_RS12205	COG0573	inorganic phosphate transmembrane transporter activity
M5J22_RS12210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5J22_RS12215	COG0768	penicillin binding
M5J22_RS12220	COG0477	Major facilitator Superfamily
M5J22_RS12225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5J22_RS12230	COG2839	Protein conserved in bacteria
M5J22_RS12235	COG5521	maltodextrose utilization protein MalA
M5J22_RS12240	COG1388	LysM domain
M5J22_RS12250	COG4709	membrane
M5J22_RS12255	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M5J22_RS12260	COG0735	belongs to the Fur family
M5J22_RS12265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS12280	COG0513	Belongs to the DEAD box helicase family
M5J22_RS12295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5J22_RS12300	COG2384	SAM-dependent methyltransferase
M5J22_RS12305	COG2010	Cytochrome c
M5J22_RS12310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5J22_RS12315	COG0358	DNA primase activity
M5J22_RS12330	COG0517	IMP dehydrogenase activity
M5J22_RS12335	COG0751	glycine-tRNA ligase activity
M5J22_RS12355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5J22_RS12360	COG0295	cytidine deaminase activity
M5J22_RS12365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5J22_RS12375	COG1480	7TM receptor with intracellular HD hydrolase
M5J22_RS12380	COG1702	phosphate starvation-inducible protein PhoH
M5J22_RS12385	COG0561	phosphatase activity
M5J22_RS12400	COG4864	UPF0365 protein
M5J22_RS12405	COG1030	water channel activity
M5J22_RS12410	COG1610	YqeY-like protein
M5J22_RS12420	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5J22_RS12425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5J22_RS12430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5J22_RS12460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5J22_RS12475	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS12505	COG0658	competence protein
M5J22_RS12505	COG2333	competence protein COMEC
M5J22_RS12510	COG2131	deaminase
M5J22_RS12515	COG1555	photosystem II stabilization
M5J22_RS12515	COG1596	polysaccharide export
M5J22_RS12520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5J22_RS12525	COG2226	methyltransferase
M5J22_RS12530	COG0799	negative regulation of ribosome biogenesis
M5J22_RS12535	COG1713	HD superfamily hydrolase involved in NAD metabolism
M5J22_RS12545	COG1534	Rna-binding protein
M5J22_RS12550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5J22_RS12555	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5J22_RS12560	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M5J22_RS12570	COG2755	lipolytic protein G-D-S-L family
M5J22_RS12580	COG0398	Pfam SNARE associated Golgi protein
M5J22_RS12605	COG2207	Transcriptional regulator
M5J22_RS12605	COG3708	Transcriptional regulator
M5J22_RS12610	COG0563	adenylate kinase activity
M5J22_RS12615	COG2814	Major facilitator Superfamily
M5J22_RS12620	COG0456	acetyltransferase
M5J22_RS12625	COG2318	DinB family
M5J22_RS12635	COG0561	phosphatase activity
M5J22_RS12640	COG0561	phosphatase activity
M5J22_RS12650	COG1482	cell wall glycoprotein biosynthetic process
M5J22_RS12655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5J22_RS12655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5J22_RS12655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS12660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS12660	COG3711	transcriptional antiterminator
M5J22_RS12670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5J22_RS12675	COG0583	DNA-binding transcription factor activity
M5J22_RS12680	COG2814	Major facilitator Superfamily
M5J22_RS12685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5J22_RS12685	COG2124	cytochrome p450
M5J22_RS12690	COG1309	transcriptional regulator
M5J22_RS12695	COG2226	methyltransferase
M5J22_RS12710	COG2116	formate transmembrane transporter activity
M5J22_RS12715	COG5609	conserved protein (DUF2294)
M5J22_RS12720	COG3383	formate dehydrogenase (NAD+) activity
M5J22_RS12725	COG2427	Protein of unknown function (DUF1641)
M5J22_RS12735	COG0626	cystathionine gamma-synthase activity
M5J22_RS12740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5J22_RS12765	COG0768	penicillin binding
M5J22_RS12780	COG0826	peptidase U32
M5J22_RS12785	COG0826	peptidase U32
M5J22_RS12790	COG4122	O-methyltransferase activity
M5J22_RS12795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5J22_RS12810	COG4472	Bacterial protein of unknown function (DUF965)
M5J22_RS12820	COG0628	permease
M5J22_RS12825	COG1126	abc transporter atp-binding protein
M5J22_RS12830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS12835	COG0765	amino acid transport
M5J22_RS12840	COG0765	amino acid transport
M5J22_RS12855	COG3881	PFAM PRC-barrel domain
M5J22_RS12860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5J22_RS12865	COG0457	Tetratricopeptide repeat
M5J22_RS12875	COG1104	cysteine desulfurase activity
M5J22_RS12880	COG1959	2 iron, 2 sulfur cluster binding
M5J22_RS12885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5J22_RS12890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5J22_RS12915	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS12915	COG3103	Sh3 type 3 domain protein
M5J22_RS12915	COG4991	sh3 domain protein
M5J22_RS12925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5J22_RS12935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5J22_RS12935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M5J22_RS12940	COG5416	Lipopolysaccharide assembly protein A domain
M5J22_RS12945	COG0490	domain, Protein
M5J22_RS12950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5J22_RS12950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5J22_RS12960	COG2244	polysaccharide biosynthetic process
M5J22_RS12965	COG2323	membrane
M5J22_RS12975	COG1862	Preprotein translocase
M5J22_RS13015	COG1388	LysM domain
M5J22_RS13025	COG0157	Belongs to the NadC ModD family
M5J22_RS13030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5J22_RS13035	COG1104	cysteine desulfurase activity
M5J22_RS13040	COG1827	regulation of RNA biosynthetic process
M5J22_RS13045	COG0077	Prephenate dehydratase
M5J22_RS13060	COG3290	protein histidine kinase activity
M5J22_RS13065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5J22_RS13070	COG2868	ribosomal protein
M5J22_RS13080	COG1994	Peptidase M50
M5J22_RS13085	COG0739	heme binding
M5J22_RS13090	COG2894	cell division
M5J22_RS13100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5J22_RS13110	COG1077	Cell shape determining protein MreB Mrl
M5J22_RS13130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M5J22_RS13135	COG0285	dihydrofolate synthase activity
M5J22_RS13140	COG0525	valine-tRNA ligase activity
M5J22_RS13150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5J22_RS13155	COG1388	LysM domain
M5J22_RS13165	COG0113	porphobilinogen synthase activity
M5J22_RS13170	COG1587	Uroporphyrinogen-III synthase
M5J22_RS13180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5J22_RS13200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5J22_RS13205	COG0470	DNA polymerase III
M5J22_RS13205	COG1067	ATP-dependent peptidase activity
M5J22_RS13220	COG0457	Tetratricopeptide repeat
M5J22_RS13220	COG1477	protein flavinylation
M5J22_RS13235	COG0473	3-isopropylmalate dehydrogenase activity
M5J22_RS13250	COG0440	acetolactate synthase activity
M5J22_RS13255	COG0028	Belongs to the TPP enzyme family
M5J22_RS13285	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M5J22_RS13305	COG0622	Phosphoesterase
M5J22_RS13310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5J22_RS13320	COG5401	PFAM Sporulation and spore germination
M5J22_RS13330	COG1846	Transcriptional regulator
M5J22_RS13335	COG2197	response regulator
M5J22_RS13340	COG0824	Thioesterase
M5J22_RS13345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5J22_RS13350	COG1053	succinate dehydrogenase
M5J22_RS13355	COG2009	succinate dehydrogenase
M5J22_RS13360	COG1719	4-vinyl reductase, 4VR
M5J22_RS13365	COG0527	aspartate kinase activity
M5J22_RS13375	COG3118	belongs to the thioredoxin family
M5J22_RS13380	COG3534	alpha-L-arabinofuranosidase
M5J22_RS13385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5J22_RS13390	COG2086	electron transfer activity
M5J22_RS13395	COG1024	Enoyl-CoA hydratase
M5J22_RS13400	COG1309	transcriptional regulator
M5J22_RS13405	COG0318	PFAM AMP-dependent synthetase and ligase
M5J22_RS13415	COG3766	membrane
M5J22_RS13425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5J22_RS13425	COG1796	DNA polymerase
M5J22_RS13430	COG1286	toxin biosynthetic process
M5J22_RS13445	COG0072	phenylalanine-tRNA ligase activity
M5J22_RS13445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5J22_RS13450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5J22_RS13455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5J22_RS13465	COG3835	regulator
M5J22_RS13470	COG0277	FAD linked oxidase domain protein
M5J22_RS13475	COG0247	lactate metabolic process
M5J22_RS13480	COG1966	Carbon starvation protein
M5J22_RS13485	COG3534	alpha-L-arabinofuranosidase
M5J22_RS13490	COG0395	ABC-type sugar transport system, permease component
M5J22_RS13495	COG1175	transmembrane transport
M5J22_RS13500	COG1653	transport
M5J22_RS13510	COG0647	UMP catabolic process
M5J22_RS13515	COG0235	Class ii aldolase
M5J22_RS13520	COG1069	ribulokinase activity
M5J22_RS13525	COG2160	L-arabinose isomerase activity
M5J22_RS13530	COG3507	Belongs to the glycosyl hydrolase 43 family
M5J22_RS13535	COG1363	Peptidase, m42
M5J22_RS13545	COG3326	Membrane
M5J22_RS13550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M5J22_RS13560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5J22_RS13565	COG1346	cytolysis
M5J22_RS13570	COG1380	Effector of murein hydrolase LrgA
M5J22_RS13575	COG3279	Response regulator of the LytR AlgR family
M5J22_RS13580	COG3275	phosphorelay sensor kinase activity
M5J22_RS13585	COG1011	Hydrolase
M5J22_RS13600	COG0398	Pfam SNARE associated Golgi protein
M5J22_RS13605	COG1484	DNA-dependent DNA replication
M5J22_RS13610	COG3611	Membrane attachment protein
M5J22_RS13625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5J22_RS13630	COG1733	regulation of RNA biosynthetic process
M5J22_RS13635	COG2814	Major facilitator Superfamily
M5J22_RS13640	COG0656	L-ascorbic acid biosynthetic process
M5J22_RS13645	COG0237	dephospho-CoA kinase activity
M5J22_RS13650	COG1971	Probably functions as a manganese efflux pump
M5J22_RS13655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5J22_RS13660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5J22_RS13660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5J22_RS13665	COG5002	protein histidine kinase activity
M5J22_RS13670	COG0745	RESPONSE REGULATOR receiver
M5J22_RS13680	COG0538	isocitrate dehydrogenase activity
M5J22_RS13685	COG0372	Belongs to the citrate synthase family
M5J22_RS13715	COG0628	permease
M5J22_RS13720	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5J22_RS13725	COG0469	pyruvate kinase activity
M5J22_RS13745	COG0281	malic enzyme
M5J22_RS13750	COG0587	DNA-directed DNA polymerase activity
M5J22_RS13770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5J22_RS13780	COG4109	DRTGG domain
M5J22_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS13805	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5J22_RS13815	COG0827	DNA restriction-modification system
M5J22_RS13820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M5J22_RS13825	COG3874	Sporulation protein YtfJ
M5J22_RS13835	COG1714	RDD family
M5J22_RS13840	COG0616	signal peptide processing
M5J22_RS13845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5J22_RS13850	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M5J22_RS13855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5J22_RS13870	COG1104	cysteine desulfurase activity
M5J22_RS13875	COG1114	Component of the transport system for branched-chain amino acids
M5J22_RS13885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5J22_RS13890	COG1309	transcriptional regulator
M5J22_RS13895	COG1956	GAF domain-containing protein
M5J22_RS13900	COG2199	diguanylate cyclase activity
M5J22_RS13900	COG2203	Gaf domain
M5J22_RS13910	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS13945	COG1017	nitric oxide dioxygenase activity
M5J22_RS13945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5J22_RS13955	COG0693	protein deglycase activity
M5J22_RS13970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5J22_RS13975	COG1378	Sugar-specific transcriptional regulator TrmB
M5J22_RS13995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5J22_RS14000	COG0454	-acetyltransferase
M5J22_RS14005	COG0517	IMP dehydrogenase activity
M5J22_RS14010	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5J22_RS14015	COG1360	Flagellar Motor Protein
M5J22_RS14020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5J22_RS14025	COG1609	Transcriptional regulator
M5J22_RS14030	COG1605	Chorismate mutase
M5J22_RS14030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M5J22_RS14035	COG3118	belongs to the thioredoxin family
M5J22_RS14040	COG4980	gas vesicle protein
M5J22_RS14045	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M5J22_RS14055	COG1674	ftsk spoiiie
M5J22_RS14060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5J22_RS14070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS14080	COG1363	Peptidase, m42
M5J22_RS14085	COG5584	Small secreted protein
M5J22_RS14090	COG0281	malic enzyme
M5J22_RS14095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5J22_RS14110	COG0510	thiamine kinase activity
M5J22_RS14115	COG1597	lipid kinase activity
M5J22_RS14125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5J22_RS14130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5J22_RS14135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5J22_RS14140	COG2252	PERMEase
M5J22_RS14145	COG4473	ABC transporter
M5J22_RS14150	COG1131	(ABC) transporter
M5J22_RS14155	COG1349	DNA-binding transcription factor activity
M5J22_RS14160	COG1187	pseudouridine synthase activity
M5J22_RS14165	COG2244	polysaccharide biosynthetic process
M5J22_RS14170	COG2081	HI0933 family
M5J22_RS14175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5J22_RS14185	COG1609	Transcriptional regulator
M5J22_RS14190	COG1653	transport
M5J22_RS14195	COG1175	transmembrane transport
M5J22_RS14200	COG0395	ABC-type sugar transport system, permease component
M5J22_RS14205	COG1486	melibiose metabolic process
M5J22_RS14215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5J22_RS14230	COG1366	Belongs to the anti-sigma-factor antagonist family
M5J22_RS14230	COG2202	Pas domain
M5J22_RS14235	COG2814	Major facilitator Superfamily
M5J22_RS14240	COG5522	Integral membrane protein (intg_mem_TP0381)
M5J22_RS14245	COG0577	efflux transmembrane transporter activity
M5J22_RS14250	COG1136	(ABC) transporter
M5J22_RS14255	COG2205	protein histidine kinase activity
M5J22_RS14260	COG0745	RESPONSE REGULATOR receiver
M5J22_RS14265	COG0577	efflux transmembrane transporter activity
M5J22_RS14270	COG1136	(ABC) transporter
M5J22_RS14290	COG1131	(ABC) transporter
M5J22_RS14295	COG1725	Transcriptional regulator
M5J22_RS14310	COG0640	Transcriptional regulator
M5J22_RS14320	COG1242	4 iron, 4 sulfur cluster binding
M5J22_RS14325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M5J22_RS14335	COG0584	glycerophosphoryl diester phosphodiesterase
M5J22_RS14345	COG2267	carboxylic ester hydrolase activity
M5J22_RS14350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5J22_RS14355	COG1113	amino acid transport
M5J22_RS14360	COG0367	asparagine synthase
M5J22_RS14380	COG1506	peptidase
M5J22_RS14385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5J22_RS14390	COG1116	anion transmembrane transporter activity
M5J22_RS14395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5J22_RS14400	COG0494	nUDIX hydrolase
M5J22_RS14405	COG4824	toxin secretion phage lysis holin
M5J22_RS14410	COG0783	Belongs to the Dps family
M5J22_RS14435	COG0288	reversible hydration of carbon dioxide
M5J22_RS14445	COG1271	oxidase subunit
M5J22_RS14450	COG1294	oxidase, subunit
M5J22_RS14460	COG4948	Mandelate Racemase Muconate Lactonizing
M5J22_RS14470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5J22_RS14475	COG0596	Alpha beta hydrolase
M5J22_RS14485	COG1169	isochorismate synthase
M5J22_RS14490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5J22_RS14495	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M5J22_RS14620	COG3859	Proton-coupled thiamine transporter YuaJ
M5J22_RS14625	COG2268	Band 7 protein
M5J22_RS14630	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5J22_RS14635	COG2318	DinB family
M5J22_RS14645	COG1454	alcohol dehydrogenase
M5J22_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS14655	COG1510	regulation of RNA biosynthetic process
M5J22_RS14665	COG0569	domain protein
M5J22_RS14670	COG1705	Flagellar rod assembly protein muramidase FlgJ
M5J22_RS14675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5J22_RS14675	COG1017	nitric oxide dioxygenase activity
M5J22_RS14695	COG0457	Tetratricopeptide repeat
M5J22_RS14720	COG0628	permease
M5J22_RS14725	COG0673	inositol 2-dehydrogenase activity
M5J22_RS14730	COG0693	protein deglycase activity
M5J22_RS14735	COG0840	transmembrane signaling receptor activity
M5J22_RS14740	COG0840	transmembrane signaling receptor activity
M5J22_RS14745	COG0840	transmembrane signaling receptor activity
M5J22_RS14750	COG0840	transmembrane signaling receptor activity
M5J22_RS14765	COG2070	2-Nitropropane dioxygenase
M5J22_RS14770	COG0432	Pfam Uncharacterised protein family UPF0047
M5J22_RS14775	COG0366	Alpha amylase catalytic
M5J22_RS14780	COG1253	flavin adenine dinucleotide binding
M5J22_RS14785	COG2738	Putative neutral zinc metallopeptidase
M5J22_RS14800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5J22_RS14825	COG1335	isochorismatase
M5J22_RS14830	COG1979	alcohol dehydrogenase
M5J22_RS14835	COG1979	alcohol dehydrogenase
M5J22_RS14840	COG2155	Conserved Protein
M5J22_RS14845	COG1098	S1 RNA binding domain
M5J22_RS14850	COG0436	Aminotransferase
M5J22_RS14855	COG1522	sequence-specific DNA binding
M5J22_RS14860	COG2267	carboxylic ester hydrolase activity
M5J22_RS14870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M5J22_RS14875	COG2205	protein histidine kinase activity
M5J22_RS14885	COG5018	Exonuclease
M5J22_RS14890	COG2814	Major facilitator Superfamily
M5J22_RS14895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5J22_RS14900	COG3011	Protein conserved in bacteria
M5J22_RS14910	COG3290	protein histidine kinase activity
M5J22_RS14915	COG4565	transcriptional regulatory protein
M5J22_RS14920	COG1744	ABC transporter substrate-binding protein PnrA-like
M5J22_RS14925	COG3845	ABC transporter
M5J22_RS14930	COG4603	Belongs to the binding-protein-dependent transport system permease family
M5J22_RS14935	COG1079	Belongs to the binding-protein-dependent transport system permease family
M5J22_RS14945	COG2111	Na H antiporter
M5J22_RS14945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5J22_RS14950	COG2111	Na H antiporter
M5J22_RS14955	COG1006	Multisubunit Na H antiporter MnhC subunit
M5J22_RS14960	COG0651	ATP synthesis coupled electron transport
M5J22_RS14965	COG1863	multisubunit Na H antiporter MnhE subunit
M5J22_RS14970	COG2212	antiporter activity
M5J22_RS14975	COG1320	monovalent cation:proton antiporter activity
M5J22_RS14980	COG2050	protein possibly involved in aromatic compounds catabolism
M5J22_RS14985	COG2197	response regulator
M5J22_RS15000	COG0142	geranyltranstransferase activity
M5J22_RS15015	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5J22_RS15020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5J22_RS15025	COG1335	isochorismatase
M5J22_RS15030	COG5506	Protein of unknown function (DUF1694)
M5J22_RS15045	COG0628	permease
M5J22_RS15055	COG1418	mRNA catabolic process
M5J22_RS15060	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS15070	COG1511	domain protein
M5J22_RS15075	COG0433	COG0433 Predicted ATPase
M5J22_RS15075	COG1674	ftsk spoiiie
M5J22_RS15080	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5J22_RS15085	COG5417	Belongs to the EsaB family
M5J22_RS15090	COG4842	Belongs to the WXG100 family
M5J22_RS15095	COG2508	Transcriptional regulator
M5J22_RS15095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5J22_RS15100	COG0686	Belongs to the AlaDH PNT family
M5J22_RS15105	COG5634	Uncharacterized conserved protein (DUF2278)
M5J22_RS15110	COG3251	PFAM MbtH domain protein
M5J22_RS15115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5J22_RS15120	COG1535	isochorismatase
M5J22_RS15120	COG3433	isochorismatase activity
M5J22_RS15125	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5J22_RS15130	COG1169	isochorismate synthase
M5J22_RS15135	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS15140	COG2819	hydrolase of the alpha beta superfamily
M5J22_RS15145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M5J22_RS15150	COG1268	BioY protein
M5J22_RS15155	COG2056	Na+-H+ antiporter family
M5J22_RS15165	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M5J22_RS15170	COG3584	3D domain protein
M5J22_RS15185	COG1252	NADH dehydrogenase
M5J22_RS15215	COG1131	(ABC) transporter
M5J22_RS15240	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M5J22_RS15245	COG0316	Belongs to the HesB IscA family
M5J22_RS15255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5J22_RS15265	COG1252	NADH dehydrogenase
M5J22_RS15270	COG4837	Protein of unknown function (DUF1462)
M5J22_RS15275	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M5J22_RS15280	COG1506	peptidase
M5J22_RS15280	COG4946	Tricorn protease homolog
M5J22_RS15280	COG0823	Involved in the tonB-independent uptake of proteins
M5J22_RS15290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5J22_RS15295	COG0460	homoserine dehydrogenase
M5J22_RS15300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5J22_RS15305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5J22_RS15310	COG0647	UMP catabolic process
M5J22_RS15315	COG2445	Protein of unknown function DUF86
M5J22_RS15320	COG4470	Protein conserved in bacteria
M5J22_RS15330	COG0739	heme binding
M5J22_RS15340	COG0737	Belongs to the 5'-nucleotidase family
M5J22_RS15345	COG0730	response to heat
M5J22_RS15350	COG1801	Protein of unknown function DUF72
M5J22_RS15365	COG2508	Transcriptional regulator
M5J22_RS15385	COG2814	Major facilitator Superfamily
M5J22_RS15390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5J22_RS15395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5J22_RS15400	COG2356	endonuclease I
M5J22_RS15405	COG3842	ATPase activity
M5J22_RS15410	COG2188	Transcriptional regulator
M5J22_RS15415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5J22_RS15420	COG0395	ABC-type sugar transport system, permease component
M5J22_RS15425	COG1175	transmembrane transport
M5J22_RS15430	COG1653	transport
M5J22_RS15435	COG2222	sugar isomerase
M5J22_RS15440	COG0789	Transcriptional regulator
M5J22_RS15450	COG0322	excinuclease ABC activity
M5J22_RS15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5J22_RS15465	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS15470	COG0719	Fe-S assembly protein
M5J22_RS15475	COG0822	iron-sulfur transferase activity
M5J22_RS15480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5J22_RS15485	COG0719	Fe-S assembly protein
M5J22_RS15490	COG0396	ATPase activity
M5J22_RS15500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5J22_RS15505	COG1464	Belongs to the NlpA lipoprotein family
M5J22_RS15510	COG2011	ABC-type metal ion transport system permease component
M5J22_RS15515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5J22_RS15525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5J22_RS15530	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5J22_RS15545	COG1393	Belongs to the ArsC family
M5J22_RS15550	COG1960	acyl-CoA dehydrogenase activity
M5J22_RS15555	COG0183	Belongs to the thiolase family
M5J22_RS15560	COG1024	Enoyl-CoA hydratase
M5J22_RS15560	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5J22_RS15575	COG0477	Major facilitator Superfamily
M5J22_RS15585	COG5577	PFAM Coat F domain
M5J22_RS15590	COG1846	Transcriptional regulator
M5J22_RS15595	COG0477	Major facilitator Superfamily
M5J22_RS15600	COG0583	DNA-binding transcription factor activity
M5J22_RS15620	COG1120	ATPase activity
M5J22_RS15635	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS15640	COG0783	Belongs to the Dps family
M5J22_RS15645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5J22_RS15650	COG0745	RESPONSE REGULATOR receiver
M5J22_RS15655	COG2770	Histidine kinase
M5J22_RS15655	COG2205	protein histidine kinase activity
M5J22_RS15665	COG1309	transcriptional regulator
M5J22_RS15670	COG0114	fumarate hydratase activity
M5J22_RS15680	COG0697	spore germination
M5J22_RS15685	COG0814	amino acid
M5J22_RS15695	COG2197	response regulator
M5J22_RS15700	COG4585	Histidine kinase
M5J22_RS15705	COG4758	membrane
M5J22_RS15710	COG3595	metallopeptidase activity
M5J22_RS15715	COG1842	Phage shock protein A
M5J22_RS15720	COG4758	membrane
M5J22_RS15725	COG2814	Major facilitator Superfamily
M5J22_RS15730	COG2096	Adenosyltransferase
M5J22_RS15735	COG1120	ATPase activity
M5J22_RS15740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS15745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5J22_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS15755	COG3386	PFAM SMP-30 Gluconolaconase
M5J22_RS15760	COG2205	protein histidine kinase activity
M5J22_RS15765	COG0745	RESPONSE REGULATOR receiver
M5J22_RS15775	COG1191	sigma factor activity
M5J22_RS15785	COG2140	Oxalate decarboxylase
M5J22_RS15795	COG1120	ATPase activity
M5J22_RS15800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS15805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS15810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5J22_RS15815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M5J22_RS15820	COG0531	amino acid
M5J22_RS15830	COG1988	membrane-bound metal-dependent
M5J22_RS15835	COG1368	sulfuric ester hydrolase activity
M5J22_RS15840	COG1910	domain protein
M5J22_RS15845	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5J22_RS15850	COG4149	molybdate abc transporter
M5J22_RS15855	COG2197	response regulator
M5J22_RS15860	COG3850	Histidine kinase
M5J22_RS15865	COG1131	(ABC) transporter
M5J22_RS15875	COG0842	Transport permease protein
M5J22_RS15880	COG0656	L-ascorbic acid biosynthetic process
M5J22_RS15900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5J22_RS15905	COG3973	AAA domain
M5J22_RS15910	COG2860	membrane
M5J22_RS15920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5J22_RS15925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5J22_RS15930	COG2217	Heavy metal translocating P-type atpase
M5J22_RS15935	COG2217	Heavy metal translocating P-type atpase
M5J22_RS15940	COG2608	mercury ion transmembrane transporter activity
M5J22_RS15945	COG1937	Protein conserved in bacteria
M5J22_RS15950	COG0673	inositol 2-dehydrogenase activity
M5J22_RS15960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS15965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5J22_RS15970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS15975	COG1126	abc transporter atp-binding protein
M5J22_RS15980	COG0765	amino acid transport
M5J22_RS15985	COG0765	amino acid transport
M5J22_RS15990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5J22_RS16000	COG0454	-acetyltransferase
M5J22_RS16005	COG0583	DNA-binding transcription factor activity
M5J22_RS16010	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS16015	COG2732	(Barnase) inhibitor
M5J22_RS16030	COG0557	exoribonuclease II activity
M5J22_RS16035	COG1647	Serine aminopeptidase, S33
M5J22_RS16040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5J22_RS16045	COG1476	TRANSCRIPTIONal
M5J22_RS16050	COG1396	sequence-specific DNA binding
M5J22_RS16055	COG1396	sequence-specific DNA binding
M5J22_RS16060	COG1733	regulation of RNA biosynthetic process
M5J22_RS16085	COG1131	(ABC) transporter
M5J22_RS16090	COG1174	glycine betaine transport
M5J22_RS16095	COG1732	Glycine betaine
M5J22_RS16100	COG1174	glycine betaine transport
M5J22_RS16105	COG0517	IMP dehydrogenase activity
M5J22_RS16105	COG1125	glycine betaine transport
M5J22_RS16110	COG1510	regulation of RNA biosynthetic process
M5J22_RS16115	COG1174	glycine betaine transport
M5J22_RS16120	COG1732	Glycine betaine
M5J22_RS16125	COG1174	glycine betaine transport
M5J22_RS16130	COG0517	IMP dehydrogenase activity
M5J22_RS16130	COG1125	glycine betaine transport
M5J22_RS16135	COG1510	regulation of RNA biosynthetic process
M5J22_RS16140	COG2095	MarC family integral membrane protein
M5J22_RS16145	COG3064	Membrane
M5J22_RS16150	COG4640	response to antibiotic
M5J22_RS16155	COG0456	acetyltransferase
M5J22_RS16170	COG2274	protein secretion by the type I secretion system
M5J22_RS16210	COG0126	phosphoglycerate kinase activity
M5J22_RS16220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5J22_RS16225	COG2390	Transcriptional regulator
M5J22_RS16230	COG2814	Major facilitator Superfamily
M5J22_RS16235	COG1609	Transcriptional regulator
M5J22_RS16240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS16250	COG0583	DNA-binding transcription factor activity
M5J22_RS16255	COG0697	spore germination
M5J22_RS16260	COG1113	amino acid transport
M5J22_RS16270	COG1609	Transcriptional regulator
M5J22_RS16280	COG0561	phosphatase activity
M5J22_RS16285	COG1737	Transcriptional regulator
M5J22_RS16290	COG1070	Carbohydrate kinase
M5J22_RS16315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5J22_RS16320	COG2186	Transcriptional regulator
M5J22_RS16325	COG1620	l-lactate permease
M5J22_RS16330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M5J22_RS16340	COG5039	Polysaccharide pyruvyl transferase
M5J22_RS16345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5J22_RS16350	COG0110	maltose O-acetyltransferase activity
M5J22_RS16355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5J22_RS16360	COG2244	polysaccharide biosynthetic process
M5J22_RS16365	COG1216	Glycosyl transferase, family 2
M5J22_RS16370	COG5039	Polysaccharide pyruvyl transferase
M5J22_RS16375	COG1216	Glycosyl transferase, family 2
M5J22_RS16385	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS16390	COG1215	transferase activity, transferring glycosyl groups
M5J22_RS16395	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS16400	COG1086	Polysaccharide biosynthesis protein
M5J22_RS16405	COG0489	protein tyrosine kinase activity
M5J22_RS16410	COG3944	biosynthesis protein
M5J22_RS16415	COG1396	sequence-specific DNA binding
M5J22_RS16420	COG2272	Belongs to the type-B carboxylesterase lipase family
M5J22_RS16430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5J22_RS16435	COG2364	Membrane
M5J22_RS16440	COG0456	acetyltransferase
M5J22_RS16445	COG3479	Phenolic acid decarboxylase
M5J22_RS16515	COG2223	nitrite transmembrane transporter activity
M5J22_RS16520	COG1609	Transcriptional regulator
M5J22_RS16530	COG0583	DNA-binding transcription factor activity
M5J22_RS16535	COG2828	Protein conserved in bacteria
M5J22_RS16540	COG0477	Major facilitator Superfamily
M5J22_RS16540	COG2814	Major facilitator Superfamily
M5J22_RS16545	COG1611	Belongs to the LOG family
M5J22_RS16550	COG1694	Mazg nucleotide pyrophosphohydrolase
M5J22_RS16555	COG0659	secondary active sulfate transmembrane transporter activity
M5J22_RS16560	COG0288	reversible hydration of carbon dioxide
M5J22_RS16565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5J22_RS16570	COG4290	ribonuclease
M5J22_RS16575	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5J22_RS16580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS16590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5J22_RS16600	COG1051	belongs to the nudix hydrolase family
M5J22_RS16605	COG0492	ferredoxin-NADP+ reductase activity
M5J22_RS16610	COG0791	NLP P60 protein
M5J22_RS16610	COG3883	PFAM NLP P60 protein
M5J22_RS16615	COG0457	Tetratricopeptide repeat
M5J22_RS16620	COG5002	protein histidine kinase activity
M5J22_RS16625	COG0745	RESPONSE REGULATOR receiver
M5J22_RS16635	COG1132	(ABC) transporter
M5J22_RS16640	COG0140	phosphoribosyl-ATP diphosphatase activity
M5J22_RS16640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5J22_RS16665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5J22_RS16680	COG4990	cell redox homeostasis
M5J22_RS16685	COG0110	maltose O-acetyltransferase activity
M5J22_RS16705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5J22_RS16715	COG2188	Transcriptional regulator
M5J22_RS16720	COG1309	transcriptional regulator
M5J22_RS16725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5J22_RS16730	COG1950	PFAM Membrane protein of
M5J22_RS16735	COG1983	PspC domain protein
M5J22_RS16740	COG3595	metallopeptidase activity
M5J22_RS16755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5J22_RS16765	COG4897	Protein conserved in bacteria
M5J22_RS16770	COG3848	Pyruvate phosphate dikinase
M5J22_RS16770	COG0574	Belongs to the PEP-utilizing enzyme family
M5J22_RS16775	COG1309	transcriptional regulator
M5J22_RS16780	COG2814	Major facilitator Superfamily
M5J22_RS16790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5J22_RS16800	COG0793	Belongs to the peptidase S41A family
M5J22_RS16800	COG3409	Peptidoglycan-binding domain 1 protein
M5J22_RS16805	COG3420	alginic acid biosynthetic process
M5J22_RS16810	COG2177	Part of the ABC transporter FtsEX involved in
M5J22_RS16815	COG2884	Cell division ATP-binding protein ftsE
M5J22_RS16820	COG2010	Cytochrome c
M5J22_RS16825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS16840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5J22_RS16855	COG1516	flagellar protein fliS
M5J22_RS16860	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5J22_RS16865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5J22_RS16885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5J22_RS16890	COG4786	Flagellar basal body rod
M5J22_RS16890	COG1256	bacterial-type flagellum assembly
M5J22_RS16895	COG3418	PFAM FlgN family protein
M5J22_RS16900	COG2747	anti-sigma28 factor FlgM
M5J22_RS16910	COG1040	competence protein
M5J22_RS16920	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M5J22_RS16925	COG1307	EDD domain protein, DegV family
M5J22_RS16930	COG2197	response regulator
M5J22_RS16935	COG4585	Histidine kinase
M5J22_RS16940	COG1739	Uncharacterized protein family UPF0029
M5J22_RS16945	COG1316	TRANSCRIPTIONal
M5J22_RS16950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5J22_RS16955	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS16960	COG1215	transferase activity, transferring glycosyl groups
M5J22_RS16965	COG3206	protein involved in exopolysaccharide biosynthesis
M5J22_RS16970	COG3307	-O-antigen
M5J22_RS16975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5J22_RS16980	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS16980	COG0297	glycogen (starch) synthase activity
M5J22_RS16985	COG2244	polysaccharide biosynthetic process
M5J22_RS16995	COG2247	cell wall binding repeat
M5J22_RS16995	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5J22_RS17000	COG2385	sporulation resulting in formation of a cellular spore
M5J22_RS17000	COG2247	cell wall binding repeat
M5J22_RS17010	COG1316	TRANSCRIPTIONal
M5J22_RS17015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5J22_RS17020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5J22_RS17025	COG1134	teichoic acid transport
M5J22_RS17030	COG1682	transport, permease protein
M5J22_RS17035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5J22_RS17040	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS17045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5J22_RS17050	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M5J22_RS17055	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5J22_RS17060	COG4193	domain, Protein
M5J22_RS17065	COG1482	cell wall glycoprotein biosynthetic process
M5J22_RS17070	COG0697	spore germination
M5J22_RS17075	COG0814	amino acid
M5J22_RS17085	COG1215	transferase activity, transferring glycosyl groups
M5J22_RS17090	COG2814	Major facilitator Superfamily
M5J22_RS17095	COG1316	TRANSCRIPTIONal
M5J22_RS17100	COG0561	phosphatase activity
M5J22_RS17105	COG2433	Pfam Transposase IS66
M5J22_RS17110	COG0791	NLP P60 protein
M5J22_RS17120	COG2843	Capsule synthesis protein
M5J22_RS17130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5J22_RS17135	COG0697	spore germination
M5J22_RS17140	COG0814	amino acid
M5J22_RS17150	COG1609	Transcriptional regulator
M5J22_RS17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5J22_RS17165	COG1129	ABC transporter
M5J22_RS17170	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5J22_RS17175	COG1879	ABC-type sugar transport system periplasmic component
M5J22_RS17180	COG3103	Sh3 type 3 domain protein
M5J22_RS17185	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5J22_RS17190	COG3527	Alpha-acetolactate decarboxylase
M5J22_RS17195	COG0028	Belongs to the TPP enzyme family
M5J22_RS17200	COG0583	DNA-binding transcription factor activity
M5J22_RS17205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M5J22_RS17220	COG5337	Spore coat protein CotH
M5J22_RS17230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5J22_RS17240	COG0405	Gamma-glutamyltransferase
M5J22_RS17245	COG1522	sequence-specific DNA binding
M5J22_RS17250	COG2059	Chromate
M5J22_RS17255	COG2059	Chromate
M5J22_RS17280	COG5444	nuclease activity
M5J22_RS17300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5J22_RS17305	COG4464	protein tyrosine phosphatase activity
M5J22_RS17310	COG0489	protein tyrosine kinase activity
M5J22_RS17315	COG3944	biosynthesis protein
M5J22_RS17325	COG4715	Zinc finger, swim domain protein
M5J22_RS17330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5J22_RS17335	COG0561	phosphatase activity
M5J22_RS17340	COG1349	DNA-binding transcription factor activity
M5J22_RS17345	COG0629	single-stranded DNA binding
M5J22_RS17370	COG0457	Tetratricopeptide repeat
M5J22_RS17375	COG4786	Flagellar basal body rod
M5J22_RS17380	COG4786	Flagellar basal body rod
M5J22_RS17385	COG1077	Cell shape determining protein MreB Mrl
M5J22_RS17390	COG1609	Transcriptional regulator
M5J22_RS17395	COG1846	Transcriptional regulator
M5J22_RS17400	COG2814	Major facilitator Superfamily
M5J22_RS17405	COG1953	Uracil, thiamine, allantoin
M5J22_RS17410	COG0477	Major facilitator Superfamily
M5J22_RS17415	COG1335	isochorismatase
M5J22_RS17420	COG0004	ammonium transporteR
M5J22_RS17425	COG0347	Belongs to the P(II) protein family
M5J22_RS17430	COG0772	Belongs to the SEDS family
M5J22_RS17435	COG0671	phosphoesterase, PA-phosphatase related
M5J22_RS17445	COG0739	heme binding
M5J22_RS17450	COG1247	-acetyltransferase
M5J22_RS17465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5J22_RS17475	COG0726	polysaccharide deacetylase
M5J22_RS17485	COG1959	2 iron, 2 sulfur cluster binding
M5J22_RS17500	COG0831	urea catabolic process
M5J22_RS17505	COG3237	CsbD-like
M5J22_RS17510	COG1994	Peptidase M50
M5J22_RS17515	COG0457	Tetratricopeptide repeat
M5J22_RS17525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5J22_RS17535	COG2304	oxidoreductase activity
M5J22_RS17540	COG2304	oxidoreductase activity
M5J22_RS17545	COG2385	sporulation resulting in formation of a cellular spore
M5J22_RS17550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5J22_RS17560	COG4836	Membrane
M5J22_RS17630	COG0698	ribose 5-phosphate isomerase
M5J22_RS17635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5J22_RS17645	COG0009	L-threonylcarbamoyladenylate synthase
M5J22_RS17650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5J22_RS17670	COG2890	protein-(glutamine-N5) methyltransferase activity
M5J22_RS17675	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5J22_RS17680	COG0346	lactoylglutathione lyase activity
M5J22_RS17685	COG0789	Transcriptional regulator
M5J22_RS17690	COG0679	Auxin Efflux Carrier
M5J22_RS17695	COG0281	malic enzyme
M5J22_RS17710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M5J22_RS17720	COG1494	fructose-1,6-bisphosphatase
M5J22_RS17725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5J22_RS17735	COG0191	fructose-bisphosphate aldolase activity
M5J22_RS17740	COG2204	response regulator
M5J22_RS17745	COG4821	SIS domain
M5J22_RS17760	COG2181	nitrate reductase activity
M5J22_RS17760	COG0247	lactate metabolic process
M5J22_RS17765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5J22_RS17780	COG1132	(ABC) transporter
M5J22_RS17785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5J22_RS17795	COG2181	nitrate reductase activity
M5J22_RS17800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M5J22_RS17805	COG1140	nitrate reductase beta subunit
M5J22_RS17810	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M5J22_RS17815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5J22_RS17825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5J22_RS17830	COG2223	nitrite transmembrane transporter activity
M5J22_RS17840	COG4506	Protein conserved in bacteria
M5J22_RS17845	COG0457	Tetratricopeptide repeat
M5J22_RS17855	COG0010	Belongs to the arginase family
M5J22_RS17860	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M5J22_RS17865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5J22_RS17880	COG1994	Peptidase M50
M5J22_RS17885	COG1942	4-Oxalocrotonate Tautomerase
M5J22_RS17890	COG1846	Transcriptional regulator
M5J22_RS17895	COG0531	amino acid
M5J22_RS17900	COG3465	dGTPase activity
M5J22_RS17905	COG1078	dGTPase activity
M5J22_RS17920	COG1695	Transcriptional regulator
M5J22_RS17940	COG0583	DNA-binding transcription factor activity
M5J22_RS17945	COG2855	membrane
M5J22_RS17950	COG0280	phosphate acetyltransferase
M5J22_RS17960	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS17965	COG0436	Aminotransferase
M5J22_RS17995	COG2814	Major facilitator Superfamily
M5J22_RS18000	COG2814	Major facilitator Superfamily
M5J22_RS18005	COG0833	amino acid
M5J22_RS18010	COG4187	Peptidase family M20/M25/M40
M5J22_RS18015	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS18020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5J22_RS18030	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M5J22_RS18035	COG1091	dTDP-4-dehydrorhamnose reductase activity
M5J22_RS18040	COG1088	dTDP-glucose 4,6-dehydratase activity
M5J22_RS18045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M5J22_RS18050	COG3980	spore coat polysaccharide biosynthesis protein
M5J22_RS18055	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M5J22_RS18060	COG2089	acid synthase
M5J22_RS18065	COG0456	acetyltransferase
M5J22_RS18070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5J22_RS18075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5J22_RS18080	COG0463	Glycosyl transferase, family 2
M5J22_RS18090	COG2363	Small membrane protein
M5J22_RS18095	COG2233	PERMEase
M5J22_RS18110	COG1216	Glycosyl transferase, family 2
M5J22_RS18125	COG1695	Transcriptional regulator
M5J22_RS18130	COG0351	phosphomethylpyrimidine kinase
M5J22_RS18140	COG1621	beta-fructofuranosidase activity
M5J22_RS18145	COG1263	PTS System
M5J22_RS18145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5J22_RS18150	COG3711	transcriptional antiterminator
M5J22_RS18160	COG1404	Belongs to the peptidase S8 family
M5J22_RS18165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5J22_RS18170	COG0778	Nitroreductase
M5J22_RS18175	COG0772	Belongs to the SEDS family
M5J22_RS18180	COG0454	-acetyltransferase
M5J22_RS18200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5J22_RS18205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5J22_RS18210	COG2261	transglycosylase associated protein
M5J22_RS18215	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M5J22_RS18225	COG2246	polysaccharide biosynthetic process
M5J22_RS18230	COG1309	transcriptional regulator
M5J22_RS18250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5J22_RS18255	COG2837	iron assimilation
M5J22_RS18275	COG0583	DNA-binding transcription factor activity
M5J22_RS18285	COG1346	cytolysis
M5J22_RS18290	COG4895	conserved protein (DUF2196)
M5J22_RS18295	COG0789	Transcriptional regulator
M5J22_RS18300	COG5504	Zn-dependent protease
M5J22_RS18305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5J22_RS18310	COG0346	lactoylglutathione lyase activity
M5J22_RS18315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS18320	COG1404	Belongs to the peptidase S8 family
M5J22_RS18325	COG1442	glycosyl transferase family 8
M5J22_RS18330	COG2357	RelA SpoT domain protein
M5J22_RS18335	COG1575	Belongs to the MenA family. Type 1 subfamily
M5J22_RS18350	COG1696	Membrane protein involved in D-alanine export
M5J22_RS18360	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M5J22_RS18365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5J22_RS18370	COG1486	melibiose metabolic process
M5J22_RS18375	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5J22_RS18380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS18385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS18390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5J22_RS18390	COG3711	transcriptional antiterminator
M5J22_RS18400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS18405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5J22_RS18415	COG0640	Transcriptional regulator
M5J22_RS18420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M5J22_RS18425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS18430	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5J22_RS18435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5J22_RS18440	COG2723	6-phospho-beta-galactosidase activity
M5J22_RS18445	COG1940	carbohydrate kinase activity
M5J22_RS18450	COG1482	cell wall glycoprotein biosynthetic process
M5J22_RS18460	COG0753	catalase activity
M5J22_RS18465	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M5J22_RS18470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M5J22_RS18475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M5J22_RS18480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5J22_RS18485	COG4988	ABC transporter
M5J22_RS18490	COG1294	oxidase, subunit
M5J22_RS18495	COG1271	oxidase subunit
M5J22_RS18500	COG3493	citrate carrier protein
M5J22_RS18505	COG0726	polysaccharide deacetylase
M5J22_RS18510	COG3842	ATPase activity
M5J22_RS18515	COG2508	Transcriptional regulator
M5J22_RS18520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS18530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5J22_RS18545	COG4894	glucomannan catabolic process
M5J22_RS18550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5J22_RS18555	COG0500	methyltransferase
M5J22_RS18560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5J22_RS18580	COG0693	protein deglycase activity
M5J22_RS18580	COG0753	catalase activity
M5J22_RS18585	COG2851	Citrate transporter
M5J22_RS18590	COG2273	Hydrolase Family 16
M5J22_RS18600	COG2270	Major facilitator Superfamily
M5J22_RS18605	COG0513	Belongs to the DEAD box helicase family
M5J22_RS18690	COG0697	spore germination
M5J22_RS18695	COG0589	response to stress
M5J22_RS18705	COG0494	nUDIX hydrolase
M5J22_RS18710	COG3507	Belongs to the glycosyl hydrolase 43 family
M5J22_RS18735	COG0010	Belongs to the arginase family
M5J22_RS18740	COG0833	amino acid
M5J22_RS18745	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5J22_RS18750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5J22_RS18760	COG2390	Transcriptional regulator
M5J22_RS18765	COG0561	phosphatase activity
M5J22_RS18795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5J22_RS18800	COG5294	Protein conserved in bacteria
M5J22_RS18805	COG0577	efflux transmembrane transporter activity
M5J22_RS18810	COG1136	(ABC) transporter
M5J22_RS18815	COG2205	protein histidine kinase activity
M5J22_RS18820	COG0745	RESPONSE REGULATOR receiver
M5J22_RS18835	COG1082	Xylose isomerase domain protein TIM barrel
M5J22_RS18845	COG2814	Major facilitator Superfamily
M5J22_RS18875	COG1349	DNA-binding transcription factor activity
M5J22_RS18880	COG0667	Aldo Keto reductase
M5J22_RS18885	COG2814	Major facilitator Superfamily
M5J22_RS18900	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS18905	COG2197	response regulator
M5J22_RS18910	COG4585	Histidine kinase
M5J22_RS18915	COG3239	Fatty acid desaturase
M5J22_RS18920	COG1309	transcriptional regulator
M5J22_RS18925	COG1012	belongs to the aldehyde dehydrogenase family
M5J22_RS18930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5J22_RS18940	COG0640	Transcriptional regulator
M5J22_RS18945	COG2814	Major facilitator Superfamily
M5J22_RS18950	COG1714	RDD family
M5J22_RS18960	COG0450	alkyl hydroperoxide reductase
M5J22_RS18965	COG3634	alkyl hydroperoxide reductase activity
M5J22_RS18970	COG1113	amino acid transport
M5J22_RS18980	COG2080	2 iron, 2 sulfur cluster binding
M5J22_RS18995	COG2068	MobA-Related Protein
M5J22_RS19000	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M5J22_RS19060	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M5J22_RS19065	COG0667	Aldo Keto reductase
M5J22_RS19070	COG0456	acetyltransferase
M5J22_RS19075	COG0457	Tetratricopeptide repeat
M5J22_RS19080	COG0010	Belongs to the arginase family
M5J22_RS19085	COG0833	amino acid
M5J22_RS19090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5J22_RS19095	COG3829	transcription factor binding
M5J22_RS19105	COG0488	(ABC) transporter
M5J22_RS19120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5J22_RS19125	COG5002	protein histidine kinase activity
M5J22_RS19130	COG0745	RESPONSE REGULATOR receiver
M5J22_RS19135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5J22_RS19140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M5J22_RS19145	COG4853	Protein conserved in bacteria
M5J22_RS19150	COG4863	YycH protein
M5J22_RS19155	COG5002	protein histidine kinase activity
M5J22_RS19160	COG0745	RESPONSE REGULATOR receiver
M5J22_RS19190	COG0346	lactoylglutathione lyase activity
M5J22_RS19195	COG0305	Participates in initiation and elongation during chromosome replication
M5J22_RS19210	COG3093	addiction module antidote protein HigA
M5J22_RS19215	COG0297	glycogen (starch) synthase activity
M5J22_RS19225	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M5J22_RS19230	COG0438	transferase activity, transferring glycosyl groups
M5J22_RS19240	COG0515	serine threonine protein kinase
M5J22_RS19250	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M5J22_RS19255	COG4241	membrane
M5J22_RS19265	COG5577	PFAM Coat F domain
M5J22_RS19270	COG1733	regulation of RNA biosynthetic process
M5J22_RS19280	COG0697	spore germination
M5J22_RS19285	COG1621	beta-fructofuranosidase activity
M5J22_RS19290	COG1621	beta-fructofuranosidase activity
M5J22_RS19295	COG1802	Transcriptional regulator
M5J22_RS19300	COG2318	DinB family
M5J22_RS19305	COG2211	Major facilitator Superfamily
M5J22_RS19315	COG0778	Nitroreductase
M5J22_RS19320	COG1846	Transcriptional regulator
M5J22_RS19325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5J22_RS19330	COG1846	Transcriptional regulator
M5J22_RS19355	COG0583	DNA-binding transcription factor activity
M5J22_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
M5J22_RS19365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5J22_RS19370	COG0697	spore germination
M5J22_RS19380	COG1959	2 iron, 2 sulfur cluster binding
M5J22_RS19385	COG1396	sequence-specific DNA binding
M5J22_RS19395	COG1331	Highly conserved protein containing a thioredoxin domain
M5J22_RS19400	COG1266	CAAX protease self-immunity
M5J22_RS19405	COG0477	Major facilitator Superfamily
M5J22_RS19405	COG2814	Major facilitator Superfamily
M5J22_RS19410	COG0346	lactoylglutathione lyase activity
M5J22_RS19415	COG1609	Transcriptional regulator
M5J22_RS19420	COG0708	Exodeoxyribonuclease III
M5J22_RS19425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5J22_RS19430	COG2169	Transcriptional regulator
M5J22_RS19440	COG0629	single-stranded DNA binding
M5J22_RS19450	COG0012	GTP binding
M5J22_RS19455	COG0243	molybdopterin cofactor binding
M5J22_RS19460	COG4481	Protein conserved in bacteria
M5J22_RS19465	COG3949	Membrane
M5J22_RS19480	COG1475	DNA binding
M5J22_RS19485	COG1192	Involved in chromosome partitioning
M5J22_RS19510	COG1847	R3H domain protein
M5J22_RS19515	COG0706	membrane insertase activity