locus-tag class description DXX91_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DXX91_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DXX91_RS00015 ENOG410848D S4 domain protein YaaA DXX91_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DXX91_RS00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXX91_RS00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXX91_RS00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DXX91_RS00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DXX91_RS00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DXX91_RS00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DXX91_RS00095 ENOG4105BZW Glycerate kinase DXX91_RS00105 ENOG4105ZMH deoxynucleoside kinase DXX91_RS00115 ENOG4105VRS hydrolase family 18 DXX91_RS00120 ENOG4105GTG Isochorismatase DXX91_RS00125 ENOG4108Z6B deaminase DXX91_RS00135 ENOG4105C6E dna polymerase iii DXX91_RS00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DXX91_RS00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DXX91_RS00155 ENOG41067KS pro-sigma K processing DXX91_RS00195 ENOG4105CDW Resistance protein DXX91_RS00200 ENOG4105CXN decarboxylase DXX91_RS00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DXX91_RS00210 ENOG4105X0R protein from nitrogen regulatory protein P-II DXX91_RS00215 ENOG4105XVJ Protein of unknown function (DUF327) DXX91_RS00220 ENOG4105FA2 dna polymerase iii DXX91_RS00225 ENOG4105MA4 psp1 domain protein DXX91_RS00235 ENOG41060K3 Methyltransferase DXX91_RS00240 ENOG4105VC4 domain protein DXX91_RS00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DXX91_RS00250 ENOG4105KRN Transcriptional regulator, abrb family DXX91_RS00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DXX91_RS00260 ENOG4105F8V Hydrolase, tatD family DXX91_RS00265 ENOG41069ER domain protein DXX91_RS00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DXX91_RS00280 ENOG4105XFA sporulation peptidase YabG DXX91_RS00285 ENOG4105W42 Veg protein DXX91_RS00290 ENOG4105XEW small acid-soluble spore protein DXX91_RS00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DXX91_RS00300 ENOG4105DFT pur operon repressor DXX91_RS00305 ENOG4105KME endoribonuclease L-psp DXX91_RS00310 ENOG4105K4W Could be involved in septation (By similarity) DXX91_RS00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DXX91_RS00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DXX91_RS00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DXX91_RS00340 ENOG4108JA2 transcriptioN-repair coupling factor DXX91_RS00345 ENOG4108M14 stage v sporulation protein t DXX91_RS00355 ENOG4108IY2 MazG family DXX91_RS00360 ENOG41082I2 s4 domain protein DXX91_RS00365 ENOG4105VYY sporulation protein yabp DXX91_RS00380 ENOG41060GV RNA binding s1 domain protein DXX91_RS00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DXX91_RS00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase DXX91_RS00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DXX91_RS00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DXX91_RS00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DXX91_RS00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DXX91_RS00440 ENOG4105C6T cysteine synthase DXX91_RS00445 ENOG4105CRQ synthase (Component I) DXX91_RS00450 ENOG4105DDQ anthranilate synthase DXX91_RS00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DXX91_RS00460 ENOG4105EEI dihydropteroate synthase DXX91_RS00465 ENOG4105KRF dihydroneopterin aldolase DXX91_RS00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DXX91_RS00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DXX91_RS00485 ENOG4105CRK lysyL-tRNA synthetase DXX91_RS00570 ENOG4108Z0C Uvrb UvrC protein DXX91_RS00575 ENOG41066A3 ATP guanido phosphotransferase DXX91_RS00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DXX91_RS00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DXX91_RS00595 ENOG4105CTP PilT protein domain protein DXX91_RS00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DXX91_RS00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DXX91_RS00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DXX91_RS00620 ENOG4105D7W serine acetyltransferase DXX91_RS00630 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DXX91_RS00635 ENOG4105C2N RNA methyltransferase TrmH family group 3 DXX91_RS00640 ENOG4105M0M Tetracycline resistance protein DXX91_RS00660 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DXX91_RS00675 ENOG4108VZM 50s ribosomal protein L10 DXX91_RS00685 ENOG4107Y49 methyltransferase DXX91_RS00690 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXX91_RS00695 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXX91_RS00700 ENOG4105XPM ribosomal protein DXX91_RS00705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DXX91_RS00710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DXX91_RS00715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DXX91_RS00720 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DXX91_RS00725 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DXX91_RS00730 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DXX91_RS00735 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DXX91_RS00740 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DXX91_RS00750 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DXX91_RS00765 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DXX91_RS00780 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DXX91_RS00795 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DXX91_RS00805 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DXX91_RS00810 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DXX91_RS00815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DXX91_RS00820 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DXX91_RS00830 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DXX91_RS00835 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DXX91_RS00840 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DXX91_RS00845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DXX91_RS00860 ENOG41067V7 50S ribosomal protein L36 DXX91_RS00865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DXX91_RS00870 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DXX91_RS00875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXX91_RS00880 ENOG4108ZT0 50S ribosomal protein l17 DXX91_RS00885 ENOG4108JJB ABC transporter DXX91_RS00890 ENOG4108JJB ABC transporter DXX91_RS00895 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DXX91_RS00900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DXX91_RS00905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DXX91_RS00910 ENOG4108UJD 30S ribosomal protein S9 DXX91_RS00915 ENOG4108I0C methyltransferase DXX91_RS00935 ENOG4105D1F ATP-binding protein DXX91_RS00950 ENOG4108NMV polysaccharide deacetylase DXX91_RS01015 ENOG4108JPW Aminotransferase DXX91_RS01025 ENOG4105CPQ Dehydrogenase DXX91_RS01030 ENOG4105CHH sulfate transporter DXX91_RS01040 ENOG4108SA1 esterase DXX91_RS01060 ENOG410874W AraC family transcriptional regulator DXX91_RS01065 ENOG4105EHZ conserved protein UCP016719 DXX91_RS01070 ENOG4105D17 glycoside hydrolase, family 3 domain protein DXX91_RS01085 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DXX91_RS01095 ENOG4105EWC Purine nucleoside phosphorylase DXX91_RS01125 ENOG4105EMN RNA polymerase sigma factor DXX91_RS01135 ENOG4105C8B TIGR00159 family DXX91_RS01140 ENOG4107U5W ybbr family DXX91_RS01145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DXX91_RS01170 ENOG41067MG lrgb family DXX91_RS01180 ENOG41061AU MarR family Transcriptional regulator DXX91_RS01195 ENOG4105BZU Histidine kinase DXX91_RS01200 ENOG4105WH1 Two component transcriptional regulator luxr family DXX91_RS01205 ENOG4105CJ1 ABC, transporter DXX91_RS01230 ENOG4106DDH Sporulation-specific SASP protein DXX91_RS01245 ENOG4107QTZ amino acid DXX91_RS01250 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DXX91_RS01255 ENOG4105CXY transporter DXX91_RS01295 ENOG4107SCQ Iron-containing alcohol dehydrogenase DXX91_RS01300 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DXX91_RS01305 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DXX91_RS01310 ENOG4107ZTW SNARE associated Golgi DXX91_RS01325 ENOG4105C72 UPF0176 protein DXX91_RS01335 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXX91_RS01340 ENOG4108IQI permease DXX91_RS01345 ENOG4108J5H Homocysteine s-methyltransferase DXX91_RS01355 ENOG4105CSV Glutaminase DXX91_RS01380 ENOG41076HS cation diffusion facilitator family transporter DXX91_RS01385 ENOG4108TVJ Nitroreductase DXX91_RS01390 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DXX91_RS01395 ENOG4108VGI doxx family DXX91_RS01400 ENOG4105XXY Thioredoxin DXX91_RS01425 ENOG4105DGI Alkaline phosphatase DXX91_RS01430 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXX91_RS01435 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXX91_RS01440 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DXX91_RS01445 ENOG4107EPV Aminotransferase class V DXX91_RS01450 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXX91_RS01455 ENOG4105J7D transcriptional regulator DXX91_RS01460 ENOG4107RB3 L-asparaginase DXX91_RS01465 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DXX91_RS01470 ENOG41060AI SEC-C motif DXX91_RS01475 ENOG4107SET aldo keto reductase DXX91_RS01505 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXX91_RS01515 ENOG4105DSE periplasmic solute binding protein DXX91_RS01520 ENOG4105DIK (ABC) transporter DXX91_RS01530 ENOG4105DEN Luciferase family DXX91_RS01535 ENOG4108N0M stress protein DXX91_RS01540 ENOG4106FN3 tellurium resistance protein DXX91_RS01545 ENOG4106FN3 tellurium resistance protein DXX91_RS01550 ENOG4107TS3 membrane protein, TerC DXX91_RS01555 ENOG4108TTB tellurium resistance protein DXX91_RS01565 ENOG41079KZ Major Facilitator Superfamily DXX91_RS01570 ENOG4108IJ7 Glycine betaine DXX91_RS01575 ENOG4107SQ8 Glycine betaine DXX91_RS01605 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DXX91_RS01635 ENOG4105EIG urea carboxylase-associated protein 1 DXX91_RS01640 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DXX91_RS01650 ENOG4105I1F Resistance protein DXX91_RS01660 ENOG4105DJB Major Facilitator Superfamily DXX91_RS01665 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DXX91_RS01670 ENOG4105I82 acetyl xylan esterase DXX91_RS01675 ENOG410756H nucleotidyltransferase DXX91_RS01685 ENOG4105C26 Dehydrogenase DXX91_RS01690 ENOG4105CK7 Sodium proline symporter DXX91_RS01695 ENOG4107YHD transcriptional regulator DXX91_RS01700 ENOG4105CAY ferredoxin--nadp reductase DXX91_RS01705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXX91_RS01710 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DXX91_RS01715 ENOG4108IFG nitrite reductase, (NAD(P)H) DXX91_RS01720 ENOG4105CKI cobalamin synthesis protein DXX91_RS01725 ENOG4105E2A Dehydrogenase DXX91_RS01730 ENOG4105HHM rdd domain containing protein DXX91_RS01760 ENOG41080HJ 6-phospho 3-hexuloisomerase DXX91_RS01765 ENOG4108VA3 3-hexulose-6-phosphate synthase DXX91_RS01770 ENOG4105KVH Transcriptional regulator DXX91_RS01775 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS01795 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DXX91_RS01810 ENOG4105CDA abc transporter atp-binding protein DXX91_RS01815 ENOG4105DRP amino acid AbC transporter DXX91_RS01825 ENOG4106P55 Transcriptional regulator DXX91_RS01830 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DXX91_RS01835 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DXX91_RS01840 ENOG41069ZX DXX91_RS01845 ENOG41069ZX DXX91_RS01850 ENOG4105DUX Transporter DXX91_RS01865 ENOG4105E1K spore germination protein DXX91_RS01890 ENOG4105EAB amino acid AbC transporter DXX91_RS01895 ENOG4108HW4 amino acid AbC transporter DXX91_RS01910 ENOG4108PGP mmge prpd family protein DXX91_RS01920 ENOG4107WD8 ABC transporter, permease DXX91_RS01925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS01930 ENOG4105BZU Histidine kinase DXX91_RS01950 ENOG4105CFH Aspartokinase DXX91_RS01960 ENOG4105DHS permease protein DXX91_RS01965 ENOG4105CM4 permease protein DXX91_RS01970 ENOG4108IPW abc transporter atp-binding protein DXX91_RS01985 ENOG4105R8C Transcriptional regulator DXX91_RS01990 ENOG4108DBC nitroreductase DXX91_RS01995 ENOG41067V3 Antibiotic biosynthesis monooxygenase DXX91_RS02000 ENOG4105YVS arsR family transcriptional regulator DXX91_RS02010 ENOG4108JPW Aminotransferase DXX91_RS02015 ENOG4105C26 Dehydrogenase DXX91_RS02025 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXX91_RS02030 ENOG4105KTB nuclear export factor GLE1 DXX91_RS02035 ENOG4108T5E Copper resistance protein DXX91_RS02040 ENOG4108ZYE Transcriptional regulator DXX91_RS02060 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DXX91_RS02080 ENOG4105E7W lamb ycsf family protein DXX91_RS02085 ENOG4105C5A transporter DXX91_RS02090 ENOG4105CFM UPF0317 protein DXX91_RS02095 ENOG4105P4J Allophanate hydrolase, subunit 1 DXX91_RS02105 ENOG4107258 Transcriptional regulator DXX91_RS02110 ENOG4105XJB lipolytic protein G-D-S-L family DXX91_RS02120 ENOG41061CK Antibiotic biosynthesis monooxygenase DXX91_RS02125 ENOG4107RVG penicillin-binding protein DXX91_RS02130 ENOG4107QM2 Aldo Keto reductase DXX91_RS02135 ENOG4105ETD TRANSCRIPTIONal DXX91_RS02145 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXX91_RS02160 ENOG410606W general stress protein DXX91_RS02170 ENOG4105VCH membrane DXX91_RS02180 ENOG4105C9U ATP-dependent DNA helicase RecQ DXX91_RS02195 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DXX91_RS02200 ENOG4107R8N Glycosyl transferase, family 2 DXX91_RS02210 ENOG4105C0X amino acid DXX91_RS02300 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DXX91_RS02315 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DXX91_RS02320 ENOG4105RXJ DXX91_RS02325 ENOG4105KPY Small multidrug resistance protein DXX91_RS02330 ENOG4105EU9 DXX91_RS02335 ENOG4105QVS general stress protein DXX91_RS02340 ENOG41082W1 Cupin 2, conserved barrel domain protein DXX91_RS02355 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DXX91_RS02360 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DXX91_RS02365 ENOG4108MRH transcriptional regulatory protein DXX91_RS02370 ENOG4107QJT sodium dicarboxylate symporter DXX91_RS02375 ENOG4106F5Q Membrane DXX91_RS02380 ENOG4105CJ1 ABC, transporter DXX91_RS02395 ENOG4105FDT acyl-CoA dehydrogenase DXX91_RS02415 ENOG4105SZ6 Thioredoxin DXX91_RS02420 ENOG4105CPF Cell wall formation (By similarity) DXX91_RS02425 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DXX91_RS02430 ENOG4105C1J atp-dependent rna helicase DXX91_RS02435 ENOG410905X membrane-flanked domain protein DXX91_RS02440 ENOG4105CKV Membrane DXX91_RS02450 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DXX91_RS02455 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DXX91_RS02460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXX91_RS02470 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DXX91_RS02475 ENOG4107MMM Anti-sigma-factor antagonist DXX91_RS02480 ENOG4105FUA antagonist DXX91_RS02485 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DXX91_RS02490 ENOG4107SGM protein serine threonine phosphatase DXX91_RS02495 ENOG4105WN5 stage II sporulation protein DXX91_RS02500 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXX91_RS02510 ENOG41064BQ Phosphatase DXX91_RS02525 ENOG410906U SprT-like DXX91_RS02565 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXX91_RS02570 ENOG4105C94 Transporter DXX91_RS02575 ENOG4105CSH Transporter DXX91_RS02590 ENOG4105K56 Transcriptional regulator DXX91_RS02600 ENOG4108Z40 Transcriptional regulator DXX91_RS02605 ENOG4108RYK Nad-dependent epimerase dehydratase DXX91_RS02610 ENOG4105VEQ Cold shock protein DXX91_RS02620 ENOG4105XTG Pfam:DUF156 DXX91_RS02625 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DXX91_RS02635 ENOG4105VFE sira family DXX91_RS02640 ENOG4107TPS domain protein DXX91_RS02645 ENOG4105VFE sira family DXX91_RS02650 ENOG41087NI Sulfite exporter TauE/SafE DXX91_RS02670 ENOG4105IRW patatin-like phospholipase family protein DXX91_RS02695 ENOG4105DNP FAD linked oxidase domain protein DXX91_RS02705 ENOG4105PGM cation diffusion facilitator family transporter DXX91_RS02710 ENOG4105H3G oxidoreductase DXX91_RS02730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DXX91_RS02755 ENOG4105DQ4 alcohol dehydrogenase DXX91_RS02760 ENOG4105VUF Transcriptional regulator DXX91_RS02770 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXX91_RS02785 ENOG4105EQ0 Major Facilitator superfamily DXX91_RS02790 ENOG4108JGH Tetr family transcriptional regulator DXX91_RS02810 ENOG4105E2A Dehydrogenase DXX91_RS02815 ENOG4105PGS Spore coat protein DXX91_RS02825 ENOG4105ENE Histidine kinase DXX91_RS02830 ENOG4108VB1 regulatoR DXX91_RS02835 ENOG4105EYF MMPL domain protein DXX91_RS02855 ENOG4108JYZ YitT family DXX91_RS02865 ENOG4105C2C drug resistance transporter, Bcr CflA DXX91_RS02870 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DXX91_RS02890 ENOG41090E6 transcriptional regulator MERR family DXX91_RS02905 ENOG4105F2W methyltransferase DXX91_RS02910 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXX91_RS02915 ENOG4105DRR Transcriptional regulator, GntR family DXX91_RS02935 ENOG4105FQP Beta-lactamase DXX91_RS02940 ENOG41090UD (LipO)protein DXX91_RS02945 ENOG4108SUT Major Facilitator Superfamily DXX91_RS02950 ENOG4108TZY GntR Family Transcriptional Regulator DXX91_RS02955 ENOG4105JXH GntR family transcriptional regulator DXX91_RS02960 ENOG4105DJ2 Major Facilitator Superfamily DXX91_RS02980 ENOG4107QTZ amino acid DXX91_RS03000 ENOG4107QNK )-transporter DXX91_RS03040 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DXX91_RS03045 ENOG4105K8N protein family UPF0079, ATPase DXX91_RS03050 ENOG41072GX Peptidase M22 Glycoprotease DXX91_RS03055 ENOG410801F ribosomal-protein-alanine acetyltransferase DXX91_RS03060 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXX91_RS03065 ENOG4105C5H ABC transporter DXX91_RS03070 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DXX91_RS03075 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DXX91_RS03080 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXX91_RS03085 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXX91_RS03095 ENOG4108TYN CAAX amino terminal protease family protein DXX91_RS03105 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DXX91_RS03125 ENOG41067QW Transcriptional regulator DXX91_RS03130 ENOG4106A7E Transcriptional regulator DXX91_RS03195 ENOG4105QBX endodeoxyribonuclease RusA DXX91_RS03445 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXX91_RS03460 ENOG4106BHF DXX91_RS03480 ENOG4105DZR Type I site-specific deoxyribonuclease DXX91_RS03485 ENOG4105PGZ NB-ARC domain DXX91_RS03490 ENOG4105CPQ Dehydrogenase DXX91_RS03495 ENOG4105CT4 transporter DXX91_RS03510 ENOG41087YS Phage shock protein A DXX91_RS03515 ENOG4105DQX Zinc finger domain DXX91_RS03520 ENOG4108WV1 Pfam:DUF477 DXX91_RS03530 ENOG4105EXC Acyl-transferase DXX91_RS03535 ENOG4108P49 AntiSigma factor DXX91_RS03540 ENOG4105JVQ RNA Polymerase DXX91_RS03565 ENOG4107STQ Multicopper oxidase DXX91_RS03570 ENOG4105C85 amino acid DXX91_RS03575 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DXX91_RS03590 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DXX91_RS03605 ENOG4105C7N Xanthine uracil vitamin C permease DXX91_RS03630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DXX91_RS03635 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DXX91_RS03640 ENOG4105C83 adenylosuccinate lyase DXX91_RS03645 ENOG4105C8V SAICAR synthetase DXX91_RS03650 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DXX91_RS03655 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DXX91_RS03660 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DXX91_RS03670 ENOG4105CXB phosphoribosylaminoimidazole synthetase DXX91_RS03675 ENOG4108V3E phosphoribosylglycinamide formyltransferase DXX91_RS03680 ENOG4105DC1 bifunctional purine biosynthesis protein purh DXX91_RS03685 ENOG4105C12 Phosphoribosylglycinamide synthetase DXX91_RS03700 ENOG4108R5T secreted protein DXX91_RS03705 ENOG4105KGF protein, YerC YecD DXX91_RS03710 ENOG4105CBC glutamate synthase DXX91_RS03725 ENOG4105C4R Atp-dependent dna helicase DXX91_RS03730 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DXX91_RS03740 ENOG4105CRN Aminoglycoside phosphotransferase DXX91_RS03745 ENOG4105KT7 mgtC SapB transporter DXX91_RS03750 ENOG4105CK7 Sodium proline symporter DXX91_RS03755 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXX91_RS03760 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DXX91_RS03765 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXX91_RS03770 ENOG4108IG5 Transcriptional regulator DXX91_RS03780 ENOG4105CBD Diacylglycerol kinase DXX91_RS03785 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXX91_RS03830 ENOG4105CDY transcriptional regulatory protein DXX91_RS03840 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DXX91_RS03855 ENOG4105WEF catalase DXX91_RS03860 ENOG4105M18 -acetyltransferase DXX91_RS03870 ENOG4105H67 Protein of unknown function (DUF421) DXX91_RS03875 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DXX91_RS03880 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DXX91_RS03905 ENOG4106I4J membrane DXX91_RS03910 ENOG41082F9 transcriptional regulator DXX91_RS03915 ENOG41061H0 Monooxygenase DXX91_RS03920 ENOG4108R1P DXX91_RS03925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXX91_RS03940 ENOG4105CJ1 ABC, transporter DXX91_RS03990 ENOG4105E0M Sulfatase DXX91_RS03995 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DXX91_RS04005 ENOG41090R9 glycosyltransferase DXX91_RS04010 ENOG4107R51 Glycosyl transferase, family 2 DXX91_RS04015 ENOG41090R9 glycosyltransferase DXX91_RS04020 ENOG4105EU0 Major facilitator Superfamily DXX91_RS04025 ENOG4105CUB amino acid DXX91_RS04030 ENOG4105C26 Dehydrogenase DXX91_RS04035 ENOG4105FKZ Methyl-accepting chemotaxis DXX91_RS04040 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXX91_RS04045 ENOG4107TVC Glycosyl transferase, family 2 DXX91_RS04050 ENOG4105C5H ABC transporter DXX91_RS04055 ENOG4107SWG transcriptional regulator MERR family DXX91_RS04060 ENOG4105DXB Major Facilitator superfamily DXX91_RS04065 ENOG4105C5H ABC transporter DXX91_RS04070 ENOG4105FDU atp-dependent rna helicase DXX91_RS04080 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DXX91_RS04095 ENOG4108J20 pectate lyase DXX91_RS04100 ENOG4107QPK )-transporter DXX91_RS04125 ENOG4108VAC response regulator DXX91_RS04145 ENOG4108MRH transcriptional regulatory protein DXX91_RS04170 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) DXX91_RS04175 ENOG4108RPX mosc domain containing protein DXX91_RS04195 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DXX91_RS04235 ENOG4105C5Y PTS System DXX91_RS04240 ENOG4105CG3 alpha amylase, catalytic region DXX91_RS04245 ENOG4107414 GntR family transcriptional regulator DXX91_RS04250 ENOG4108RCM Nitroreductase DXX91_RS04265 ENOG4105CGH 5'-nucleotidase DXX91_RS04270 ENOG4107RKG DJ-1/PfpI family DXX91_RS04275 ENOG4105ETE Transcriptional regulator (LacI family DXX91_RS04285 ENOG4105FF2 Type I DHQase DXX91_RS04300 ENOG4105KJF protein tyrosine phosphatase DXX91_RS04310 ENOG4107U9T Pfam:Ribonuclease_BN DXX91_RS04315 ENOG4108ISG Major Facilitator DXX91_RS04320 ENOG4105UPD Calcium Proton DXX91_RS04330 ENOG4105D8X mechanosensitive ion channel DXX91_RS04350 ENOG4106KE4 Dehydrogenase DXX91_RS04360 ENOG4105D7N magnesium and cobalt transport protein CorA DXX91_RS04370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXX91_RS04400 ENOG4105DA5 (ABC) transporter DXX91_RS04410 ENOG4105CJ1 ABC, transporter DXX91_RS04415 ENOG4108SDH ABC, transporter DXX91_RS04440 ENOG4107RUY (E1 component), alpha subunit DXX91_RS04450 ENOG4107QKR Dehydrogenase DXX91_RS04460 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DXX91_RS04470 ENOG4105F8D glycoside hydrolase family 4 DXX91_RS04475 ENOG4108Q3X Transcriptional regulator DXX91_RS04480 ENOG4105CI1 PTS System DXX91_RS04485 ENOG4105BZ1 (ABC) transporter DXX91_RS04490 ENOG4105BZ1 (ABC) transporter DXX91_RS04500 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DXX91_RS04510 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXX91_RS04515 ENOG4105U3E Transcriptional regulator DXX91_RS04520 ENOG4105DYS nad(p)h dehydrogenase (quinone) DXX91_RS04525 ENOG4105H93 Acyltransferase family DXX91_RS04540 ENOG4108YYS metal-dependent hydrolase (By similarity) DXX91_RS04545 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXX91_RS04550 ENOG410834F Transcriptional regulator DXX91_RS04560 ENOG4105JAB phenazine biosynthesis protein, phzf family DXX91_RS04565 ENOG4107Y03 Nitroreductase DXX91_RS04580 ENOG4105ECP epimerase DXX91_RS04585 ENOG410902V Modulates RecA activity (By similarity) DXX91_RS04595 ENOG4105F27 Major Facilitator DXX91_RS04605 ENOG4108TCS Glutamyl endopeptidase DXX91_RS04625 ENOG4106AKJ DXX91_RS04630 ENOG4105D74 hydrolase DXX91_RS04635 ENOG4105CKK Glycosyl transferase, family 2 DXX91_RS04640 ENOG4105EJV Membrane DXX91_RS04645 ENOG41067AE Membrane-bound metal-dependent hydrolase DXX91_RS04650 ENOG4105CEN a g-specific adenine glycosylase DXX91_RS04655 ENOG4106BXE DXX91_RS04660 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DXX91_RS04680 ENOG4105BZ1 (ABC) transporter DXX91_RS04685 ENOG4107NBY Membrane DXX91_RS04690 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DXX91_RS04695 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXX91_RS04700 ENOG4105G5W regulator Fur family DXX91_RS04705 ENOG4105TUA UPF0295 protein DXX91_RS04815 ENOG4105EC3 peptidase S51, dipeptidase E DXX91_RS04820 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DXX91_RS04825 ENOG4105DNP FAD linked oxidase domain protein DXX91_RS04835 ENOG4105DEF Extracellular solute-binding protein, family 5 DXX91_RS04845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXX91_RS04850 ENOG4105C3U ABC transporter DXX91_RS04855 ENOG4108JQ7 (ABC) transporter DXX91_RS04870 ENOG4105E2Y ABC, transporter DXX91_RS04875 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DXX91_RS04880 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DXX91_RS04890 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DXX91_RS04895 ENOG4107D63 DXX91_RS04900 ENOG4105VZ8 Transcriptional regulator DXX91_RS04915 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DXX91_RS04925 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DXX91_RS04945 ENOG4105CYN Serine protein kinase DXX91_RS04960 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DXX91_RS04965 ENOG4105CW7 secretion protein, HlyD family DXX91_RS04970 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXX91_RS04975 ENOG4105CS1 NAD(P)H quinone oxidoreductase DXX91_RS04990 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DXX91_RS04995 ENOG4105CZV ABC transporter DXX91_RS05000 ENOG4105CJ1 ABC, transporter DXX91_RS05005 ENOG4108TU7 Inherit from COG: (ABC) transporter DXX91_RS05010 ENOG4105VEQ Cold shock protein DXX91_RS05025 ENOG4105BZU Histidine kinase DXX91_RS05065 ENOG4108YBP pseudouridine synthase DXX91_RS05075 ENOG41080XP Cbs domain DXX91_RS05080 ENOG4107YBY Hydrolase DXX91_RS05085 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXX91_RS05090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXX91_RS05095 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DXX91_RS05105 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DXX91_RS05110 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DXX91_RS05120 ENOG4105BZU Histidine kinase DXX91_RS05125 ENOG4105WH1 Two component transcriptional regulator luxr family DXX91_RS05160 ENOG4105ED1 spovr family DXX91_RS05165 ENOG4105G6Z alkaline phosphatase DXX91_RS05180 ENOG4105BZN citrate synthase DXX91_RS05185 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXX91_RS05190 ENOG4105CUB amino acid DXX91_RS05195 ENOG4105C8J )-transporter DXX91_RS05205 ENOG4105J37 DXX91_RS05210 ENOG4108AEY RNA polymerase sigma factor DXX91_RS05215 ENOG4105F6E Acyl-transferase DXX91_RS05220 ENOG4105C37 (CBS) domain DXX91_RS05230 ENOG4105CHM Aminotransferase DXX91_RS05235 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DXX91_RS05240 ENOG4105C37 (CBS) domain DXX91_RS05250 ENOG4105WMR Protein CrcB homolog DXX91_RS05255 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXX91_RS05265 ENOG4105D64 Mechanosensitive ion channel DXX91_RS05270 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DXX91_RS05275 ENOG4107VMI polysaccharide deacetylase DXX91_RS05280 ENOG4105F0I Aminotransferase DXX91_RS05285 ENOG4105W1N transcriptional regulator DXX91_RS05290 ENOG4105IIP Membrane DXX91_RS05300 ENOG4105BZ1 (ABC) transporter DXX91_RS05305 ENOG4105BZ1 (ABC) transporter DXX91_RS05330 ENOG410839P DXX91_RS05340 ENOG4106MP8 UPF0754 membrane protein DXX91_RS05345 ENOG4105WZB UPF0342 protein DXX91_RS05350 ENOG4105F1N DNA alkylation repair DXX91_RS05360 ENOG4105D4P Coproporphyrinogen iii oxidase DXX91_RS05370 ENOG4107S91 Sodium hydrogen exchanger DXX91_RS05375 ENOG4105NCW Trka-c domain protein DXX91_RS05385 ENOG4105CGU Enoyl-CoA hydratase DXX91_RS05395 ENOG4108IUX (ABC) transporter DXX91_RS05400 ENOG4105RHA ABC transporter, permease DXX91_RS05405 ENOG4107VRP DNA repair exonuclease DXX91_RS05410 ENOG4106D4I domain protein DXX91_RS05415 ENOG4105EQI Metal Dependent Phosphohydrolase DXX91_RS05425 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DXX91_RS05475 ENOG4105NBU tryptophan transport protein DXX91_RS05480 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DXX91_RS05485 ENOG4105K59 histidine triad (HIT) protein DXX91_RS05515 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DXX91_RS05520 ENOG4105BZ4 penicillin-binding protein DXX91_RS05525 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DXX91_RS05530 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DXX91_RS05535 ENOG4105C1Q protoporphyrinogen oxidase DXX91_RS05545 ENOG4105ECB domain protein DXX91_RS05560 ENOG4105DER m42 family DXX91_RS05570 ENOG4106AXD DXX91_RS05575 ENOG4108RQ5 Beta-lactamase domain-containing protein DXX91_RS05580 ENOG4105DF9 Lipoate-protein, ligase DXX91_RS05590 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS05600 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DXX91_RS05615 ENOG4108HUF Transporter DXX91_RS05620 ENOG4107TB6 phosphoglycerate mutase DXX91_RS05630 ENOG4107F3J Amp-dependent synthetase and ligase DXX91_RS05635 ENOG4107ZYJ bioY protein DXX91_RS05640 ENOG4106YBV Methyl-accepting chemotaxis DXX91_RS05660 ENOG4105XVF Competence transcription factor DXX91_RS05670 ENOG4108ZMX Domain of unknown function (DU1801) DXX91_RS05680 ENOG4105X3H Excalibur domain protein DXX91_RS05685 ENOG4105K8R UPF0145 protein DXX91_RS05690 ENOG4105E1V na solute symporter DXX91_RS05695 ENOG4106CAD Protein of unknown function (DUF3311) DXX91_RS05700 ENOG41060YP DXX91_RS05715 ENOG4107SCK Monooxygenase DXX91_RS05720 ENOG4108INS Transcriptional regulator DXX91_RS05725 ENOG4108KK1 membrane protein AbrB duplication DXX91_RS05735 ENOG4108IG5 Transcriptional regulator DXX91_RS05745 ENOG4108QY0 Membrane DXX91_RS05750 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DXX91_RS05755 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DXX91_RS05765 ENOG4105EYH Exonuclease DXX91_RS05810 ENOG4105ERH Fumarylacetoacetate hydrolase DXX91_RS05830 ENOG4105CAQ asparagine synthetase DXX91_RS05840 ENOG4105UQX Mate efflux family protein DXX91_RS05845 ENOG4106HBX Transcriptional Regulator AraC Family DXX91_RS05850 ENOG4105ETE Transcriptional regulator (LacI family DXX91_RS05855 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXX91_RS05860 ENOG4105SF0 DinB family DXX91_RS05870 ENOG4105MYW Pentapeptide repeat protein DXX91_RS05875 ENOG4105MA6 gCN5-related N-acetyltransferase DXX91_RS05885 ENOG4108VPT UPF0234 protein DXX91_RS05890 ENOG4105QNR S1 RNA binding domain protein DXX91_RS05895 ENOG4105DIH basic membrane DXX91_RS05900 ENOG4105C8Q Methyl-accepting chemotaxis DXX91_RS05910 ENOG4105EPR degv family DXX91_RS05915 ENOG4107AYK membrAne DXX91_RS05925 ENOG41073B9 DXX91_RS05930 ENOG4108KP7 hydrolase DXX91_RS05935 ENOG4108MXZ Esterase DXX91_RS05940 ENOG4105VG1 fes assembly suf system protein DXX91_RS05945 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DXX91_RS05950 ENOG4105IQ5 FAD linked oxidase domain protein DXX91_RS05960 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DXX91_RS05965 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DXX91_RS05970 ENOG4105CAS nag kinase DXX91_RS05975 ENOG4105C8Y Acetylornithine aminotransferase DXX91_RS05980 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXX91_RS05990 ENOG4105DBV ornithine carbamoyltransferase DXX91_RS06020 ENOG4107RMD Basic membrane lipoprotein DXX91_RS06035 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DXX91_RS06040 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DXX91_RS06050 ENOG4105C3U ABC transporter DXX91_RS06055 ENOG4108JQ7 (ABC) transporter DXX91_RS06070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXX91_RS06090 ENOG4105C31 Tryptophanyl-tRNA synthetase DXX91_RS06095 ENOG4108J59 Extracellular solute-binding protein, family 5 DXX91_RS06100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXX91_RS06105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXX91_RS06115 ENOG4108JQ7 (ABC) transporter DXX91_RS06130 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DXX91_RS06135 ENOG4108ZCF integral membrane protein DXX91_RS06140 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DXX91_RS06150 ENOG4105DPN Oligoendopeptidase f DXX91_RS06155 ENOG4105T58 Dithiol-disulfide isomerase DXX91_RS06160 ENOG4108Z18 K06886 hemoglobin DXX91_RS06165 ENOG4105E4C Lytic transglycosylase catalytic DXX91_RS06170 ENOG4105MIX Adenylate cyclase DXX91_RS06185 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXX91_RS06190 ENOG4105EMS pseudouridine synthase DXX91_RS06195 ENOG4107S1Q Phosphatase DXX91_RS06210 ENOG4105ETU transcriptional activator (TenA DXX91_RS06215 ENOG4108VEU Thiamine monophosphate synthase DXX91_RS06235 ENOG4105D06 uba thif-type nad fad binding protein DXX91_RS06240 ENOG4105DWF phosphomethylpyrimidine kinase DXX91_RS06245 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DXX91_RS06250 ENOG4107A88 DXX91_RS06300 ENOG4105ENA helicase DXX91_RS06320 ENOG4105CJ1 ABC, transporter DXX91_RS06335 ENOG4108ZMI UPF0477 protein DXX91_RS06345 ENOG4105C28 cystathionine DXX91_RS06350 ENOG4105C28 cystathionine DXX91_RS06395 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DXX91_RS06425 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase DXX91_RS06430 ENOG4105CMR udp-glucose 4-epimerase DXX91_RS06435 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DXX91_RS06440 ENOG4105CK1 PTS System DXX91_RS06445 ENOG4105VCP PTS System DXX91_RS06455 ENOG4105E98 transcriptional regulator DeoR family DXX91_RS06475 ENOG4105KT7 mgtC SapB transporter DXX91_RS06500 ENOG4108IEG Formate dehydrogenase Alpha subunit DXX91_RS06510 ENOG4106A3M Cytochrome p-450 DXX91_RS06515 ENOG41087PP glycosyltransferase MGT family DXX91_RS06525 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DXX91_RS06530 ENOG4105C4B ABC transporter, permease DXX91_RS06535 ENOG4108IXI (ABC) transporter DXX91_RS06545 ENOG4105Q95 Cupin 2, conserved barrel domain protein DXX91_RS06560 ENOG4105D2H Uronic isomerase DXX91_RS06565 ENOG4105CT4 transporter DXX91_RS06570 ENOG4107KJX Transcriptional regulator DXX91_RS06575 ENOG4107QZW Altronate oxidoreductase DXX91_RS06580 ENOG4105CTX dehydratase DXX91_RS06585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS06590 ENOG4105F3H Histidine kinase DXX91_RS06605 ENOG4107TSN permease DXX91_RS06620 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXX91_RS06625 ENOG4105KWG Pfam:DUF1696 DXX91_RS06630 ENOG4105K7W phage-related replication protein DXX91_RS06635 ENOG410635T phage-like element pbsx protein DXX91_RS06675 ENOG4108TFU terminase (Small subunit) DXX91_RS06680 ENOG4105IG6 Phage terminase, large subunit DXX91_RS06685 ENOG4108MDF Phage Portal Protein DXX91_RS06710 ENOG41060SN DXX91_RS06725 ENOG4105PQS phage protein DXX91_RS06730 ENOG4105FR7 XkdM protein, phage-like element PBSX DXX91_RS06735 ENOG4105MTC XkdN-like protein DXX91_RS06745 ENOG4108FKH Transglycosylase SLT domain DXX91_RS06745 ENOG4108FKH Transglycosylase SLT domain DXX91_RS06745 ENOG4108FKH Transglycosylase SLT domain DXX91_RS06750 ENOG4108WZM domain protein DXX91_RS06755 ENOG4105X7F DXX91_RS06765 ENOG4105MFU Protein of unknown function (DUF2634) DXX91_RS06770 ENOG41066EA baseplate J family protein DXX91_RS06775 ENOG410906S phage-like element pbsx protein xkdt DXX91_RS06785 ENOG41068G1 DXX91_RS06815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXX91_RS06830 ENOG4105CJ3 phosphate transporter DXX91_RS06835 ENOG4107GRR phosphate transport regulator DXX91_RS06840 ENOG4107R7I amino acid DXX91_RS06850 ENOG4105EDW glycosyl transferase, family 39 DXX91_RS06855 ENOG4105CKK Glycosyl transferase, family 2 DXX91_RS06860 ENOG4105C0H protease DXX91_RS06870 ENOG4108ME1 Peptidase M55 D-aminopeptidase DXX91_RS06875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXX91_RS06880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXX91_RS06885 ENOG4105C3U ABC transporter DXX91_RS06895 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DXX91_RS06900 ENOG4105DTQ mandelate racemase muconate lactonizing DXX91_RS06905 ENOG4107SN7 NLP P60 protein DXX91_RS06910 ENOG4108JQ7 (ABC) transporter DXX91_RS06915 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DXX91_RS06920 ENOG4107TUM Amidinotransferase DXX91_RS06925 ENOG4108S4H thioesterase Superfamily protein DXX91_RS06930 ENOG4108428 Inherit from COG: -acetyltransferase DXX91_RS06940 ENOG41080TC multidrug resistance protein DXX91_RS06945 ENOG4105CIY formyltetrahydrofolate deformylase DXX91_RS06950 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXX91_RS06965 ENOG4105K56 Transcriptional regulator DXX91_RS06970 ENOG4108ZHJ Organic hydroperoxide resistance protein DXX91_RS06985 ENOG4107TVC Glycosyl transferase, family 2 DXX91_RS06995 ENOG4105D8G Major Facilitator superfamily DXX91_RS07000 ENOG4108Y4K DNA-binding transcriptional activator DXX91_RS07005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DXX91_RS07010 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXX91_RS07020 ENOG4108W7F transporter, permease DXX91_RS07025 ENOG4108JJB ABC transporter DXX91_RS07030 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DXX91_RS07035 ENOG4105VRS hydrolase family 18 DXX91_RS07055 ENOG4105CJW magnesium transporter DXX91_RS07060 ENOG4105V75 Transcriptional regulator DXX91_RS07085 ENOG4105DQE DNA ligase DXX91_RS07090 ENOG4105FDF Could be involved in DNA repair (By similarity) DXX91_RS07095 ENOG4107T5V SNARE associated Golgi DXX91_RS07100 ENOG4107TS3 membrane protein, TerC DXX91_RS07105 ENOG4108WZW RNA polymerase sigma DXX91_RS07115 ENOG410681C small acid-soluble spore protein DXX91_RS07125 ENOG4105D0M Protease HtpX homolog DXX91_RS07135 ENOG410900G Protein of unknown function (DUF421) DXX91_RS07145 ENOG4108TGC Acyltransferase DXX91_RS07150 ENOG4105BZU Histidine kinase DXX91_RS07155 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXX91_RS07160 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DXX91_RS07170 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXX91_RS07180 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DXX91_RS07185 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DXX91_RS07190 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DXX91_RS07195 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DXX91_RS07205 ENOG4105BZU Histidine kinase DXX91_RS07210 ENOG41090MY MarR family Transcriptional regulator DXX91_RS07215 ENOG4105ER2 Ompa motb domain protein DXX91_RS07220 ENOG4105E14 MotA TolQ exbB proton channel DXX91_RS07235 ENOG4108K88 Membrane DXX91_RS07245 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DXX91_RS07250 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DXX91_RS07255 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DXX91_RS07260 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DXX91_RS07280 ENOG4105F0V Cell wall hydrolase DXX91_RS07295 ENOG4105C59 p-type ATPase DXX91_RS07300 ENOG4105DC7 peptidase M24 DXX91_RS07310 ENOG4105CID antiterminator DXX91_RS07320 ENOG4105KRI phosphocarrier protein (HPr DXX91_RS07325 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DXX91_RS07335 ENOG4105F6S Spore photoproduct lyase DXX91_RS07340 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DXX91_RS07345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DXX91_RS07350 ENOG4105K4I Scp-like extracellular DXX91_RS07365 ENOG4105CHM Aminotransferase DXX91_RS07375 ENOG4107R88 Chemotaxis protein (CheV) DXX91_RS07380 ENOG4105UIN DXX91_RS07390 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DXX91_RS07400 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DXX91_RS07415 ENOG4105EPM Diguanylate phosphodiesterase DXX91_RS07420 ENOG4107IN1 Protein of unknown function (DUF1797) DXX91_RS07425 ENOG4108XRC Protein of unknown function (DUF458) DXX91_RS07455 ENOG4105NQC Flavodoxin DXX91_RS07475 ENOG4105D8X mechanosensitive ion channel DXX91_RS07480 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXX91_RS07495 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DXX91_RS07500 ENOG4105D06 uba thif-type nad fad binding protein DXX91_RS07505 ENOG4105CVM Molybdenum cofactor synthesis domain protein DXX91_RS07510 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DXX91_RS07515 ENOG4108ZAF Molybdopterin DXX91_RS07520 ENOG41067WU Molybdopterin converting factor (Subunit 1) DXX91_RS07530 ENOG4107X8C Efflux transporter RND family MFP subunit DXX91_RS07535 ENOG4105C19 ABC transporter DXX91_RS07540 ENOG4107RBB ABC transporter, permease DXX91_RS07545 ENOG4105E98 transcriptional regulator DeoR family DXX91_RS07550 ENOG4105DE4 1-phosphofructokinase DXX91_RS07555 ENOG4105DM4 PTS System DXX91_RS07570 ENOG4105C5H ABC transporter DXX91_RS07575 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DXX91_RS07605 ENOG4105BZU Histidine kinase DXX91_RS07615 ENOG4107ZYR domain protein DXX91_RS07620 ENOG4105CPN adenine deaminase DXX91_RS07625 ENOG4105CN5 Metallo-Beta-Lactamase DXX91_RS07630 ENOG4106148 UPF0356 protein DXX91_RS07640 ENOG4108X4Q Hydrolase DXX91_RS07645 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXX91_RS07665 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXX91_RS07670 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS07675 ENOG4107SQU synthase DXX91_RS07680 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS07685 ENOG4107SQU synthase DXX91_RS07690 ENOG4107SQU synthase DXX91_RS07695 ENOG4107SQU synthase DXX91_RS07700 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS07705 ENOG4105FQP Beta-lactamase DXX91_RS07715 ENOG4105CPP Dehydrogenase, E1 component DXX91_RS07720 ENOG4105C7S Dehydrogenase DXX91_RS07725 ENOG4107QN2 dihydrolipoyl dehydrogenase DXX91_RS07745 ENOG4105CXN decarboxylase DXX91_RS07750 ENOG4105WBI UPF0223 protein DXX91_RS07770 ENOG4105ECY inositol monophosphatase DXX91_RS07780 ENOG4105D4Y metalloprotease DXX91_RS07805 ENOG4105CI3 gtp-binding protein typa DXX91_RS07810 ENOG4105QA2 DXX91_RS07825 ENOG4108IAB Phoh family DXX91_RS07835 ENOG4105CSV Glutaminase DXX91_RS07845 ENOG4105CNI cell division protein FtsW DXX91_RS07850 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DXX91_RS07860 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXX91_RS07870 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXX91_RS07875 ENOG4105CCU oxidase (Subunit III) DXX91_RS07880 ENOG41064X9 cytochrome C oxidase subunit IV DXX91_RS07895 ENOG41080XQ Signal transduction protein with cbs domains DXX91_RS07900 ENOG4106UY4 Inherit from COG: Scp-like extracellular DXX91_RS07930 ENOG4106H78 methyltransferase DXX91_RS07935 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DXX91_RS07940 ENOG4105H20 Sporulation integral membrane protein YlbJ DXX91_RS07945 ENOG4105D78 K07001 NTE family protein DXX91_RS07950 ENOG41063PX domain protein DXX91_RS07955 ENOG4105CDE UPF0348 protein DXX91_RS07960 ENOG4105KNH Nucleic acid-binding protein DXX91_RS07990 ENOG4108V6E Cell division protein mraZ DXX91_RS07995 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DXX91_RS08005 ENOG4105CJN penicillin-binding protein DXX91_RS08010 ENOG4105CJN penicillin-binding protein DXX91_RS08015 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DXX91_RS08020 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DXX91_RS08025 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DXX91_RS08030 ENOG4105CNI cell division protein FtsW DXX91_RS08035 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DXX91_RS08040 ENOG4105D4A Cell wall formation (By similarity) DXX91_RS08045 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DXX91_RS08050 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DXX91_RS08055 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DXX91_RS08065 ENOG4105FFI sigma-e processing peptidase spoiiga DXX91_RS08070 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS08080 ENOG4105DKW ABC transporter DXX91_RS08090 ENOG4105WR5 sporulation protein, YlmC YmxH family DXX91_RS08095 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DXX91_RS08100 ENOG4105DFA alanine racemase domain protein DXX91_RS08105 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DXX91_RS08110 ENOG41067XK integral membrane protein DXX91_RS08115 ENOG4105DBK s4 domain protein DXX91_RS08130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DXX91_RS08140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DXX91_RS08145 ENOG4105C34 Pseudouridine synthase DXX91_RS08150 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DXX91_RS08160 ENOG4105CXT aspartate transcarbamylase DXX91_RS08170 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXX91_RS08175 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DXX91_RS08180 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DXX91_RS08185 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DXX91_RS08190 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DXX91_RS08195 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DXX91_RS08210 ENOG4107RIQ Sulfate adenylate transferase DXX91_RS08220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXX91_RS08225 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DXX91_RS08230 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DXX91_RS08250 ENOG4105DSJ YicC domain protein DXX91_RS08255 ENOG4105KC4 UPF0296 protein DXX91_RS08260 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DXX91_RS08270 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DXX91_RS08275 ENOG4105C25 Primosomal protein n' DXX91_RS08280 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXX91_RS08285 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DXX91_RS08290 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DXX91_RS08295 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DXX91_RS08300 ENOG4108ZF3 Phosphatase DXX91_RS08305 ENOG4105D9P serine threonine protein kinase DXX91_RS08310 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DXX91_RS08315 ENOG4105DJV ribulose-phosphate 3-epimerase DXX91_RS08320 ENOG4105FJ0 thiamine DXX91_RS08330 ENOG4105VB9 50S ribosomal protein l28 DXX91_RS08335 ENOG4108ZAA Alkaline-shock protein DXX91_RS08340 ENOG4105DP4 dak2 domain fusion protein ylov DXX91_RS08350 ENOG4105EJQ L-serine dehydratase DXX91_RS08355 ENOG4105CB5 ATP-dependent DNA helicase recG DXX91_RS08360 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DXX91_RS08365 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DXX91_RS08370 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXX91_RS08375 ENOG4105CHR reductase DXX91_RS08385 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DXX91_RS08390 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DXX91_RS08395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DXX91_RS08405 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DXX91_RS08415 ENOG4105K5M 30s ribosomal protein S16 DXX91_RS08420 ENOG4108BW8 UPF0109 protein DXX91_RS08435 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DXX91_RS08440 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DXX91_RS08445 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DXX91_RS08450 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXX91_RS08460 ENOG4105VM1 flagellar DXX91_RS08465 ENOG4105CMV Succinyl-CoA synthetase subunit beta DXX91_RS08470 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DXX91_RS08475 ENOG4105C79 DNA protecting protein DprA DXX91_RS08480 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DXX91_RS08485 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DXX91_RS08490 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXX91_RS08495 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DXX91_RS08500 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DXX91_RS08510 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DXX91_RS08515 ENOG4108ZC9 flagellar basal-body rod protein flgc DXX91_RS08520 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DXX91_RS08525 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DXX91_RS08530 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXX91_RS08545 ENOG4106YF4 Flagellar biosynthesis chaperone DXX91_RS08555 ENOG410696Y Flagellar hook-length control protein DXX91_RS08560 ENOG410822I Flagellar hook capping protein DXX91_RS08565 ENOG4108JQA flagellar DXX91_RS08570 ENOG41068WV flagellar FlbD family protein DXX91_RS08580 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXX91_RS08585 ENOG4105DD5 Flagellar motor switch protein DXX91_RS08590 ENOG4107YTP response regulator receiver protein DXX91_RS08600 ENOG4105CN7 Flagellar biosynthetic protein FliP DXX91_RS08605 ENOG4105VS8 Flagellar biosynthetic protein fliq DXX91_RS08610 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DXX91_RS08615 ENOG4105D00 flagellar biosynthetic protein flhB DXX91_RS08620 ENOG4105D7B Flagellar biosynthesis protein flha DXX91_RS08625 ENOG4105FZW flagellar biosynthesis regulator FlhF DXX91_RS08635 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DXX91_RS08640 ENOG4105CBS Chea signal transduction histidine kinase DXX91_RS08645 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DXX91_RS08655 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DXX91_RS08660 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS08670 ENOG4105CE9 30S ribosomal protein S2 DXX91_RS08680 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DXX91_RS08685 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DXX91_RS08690 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DXX91_RS08695 ENOG4105KNE Phosphatidate cytidylyltransferase DXX91_RS08705 ENOG4105DZP Membrane-associated zinc metalloprotease DXX91_RS08710 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DXX91_RS08715 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DXX91_RS08720 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DXX91_RS08725 ENOG4105CHV Transcription elongation factor NusA DXX91_RS08730 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DXX91_RS08735 ENOG4105VHM ribosomal protein DXX91_RS08740 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DXX91_RS08745 ENOG4105W7A Protein of unknown function (DUF503) DXX91_RS08750 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DXX91_RS08755 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DXX91_RS08760 ENOG4105DTN riboflavin biosynthesis protein ribF DXX91_RS08765 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DXX91_RS08770 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DXX91_RS08780 ENOG4105C1V Peptidase, M16 DXX91_RS08790 ENOG4105E35 Dipicolinate synthase subunit A DXX91_RS08795 ENOG4108S0H Dipicolinic acid synthetase, b subunit DXX91_RS08800 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DXX91_RS08810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DXX91_RS08820 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DXX91_RS08830 ENOG4105CNU cell division protein FtsK DXX91_RS08835 ENOG4105FDP GntR family transcriptional regulator DXX91_RS08850 ENOG4105EYF MMPL domain protein DXX91_RS08865 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DXX91_RS08870 ENOG4105XZV Protein of unknown function (DUF3243) DXX91_RS08885 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DXX91_RS08890 ENOG4105CEV competence damage-inducible protein DXX91_RS08895 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DXX91_RS08900 ENOG4108A04 Beta-lactamase DXX91_RS08910 ENOG4105D48 metallophosphoesterase DXX91_RS08915 ENOG4105MCT stage V sporulation protein S DXX91_RS08920 ENOG4105CPQ Dehydrogenase DXX91_RS08925 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXX91_RS08930 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXX91_RS08950 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DXX91_RS08965 ENOG4108151 Beta-lactamase domain protein DXX91_RS08970 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXX91_RS08975 ENOG4108JA1 polyketide synthase DXX91_RS08980 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXX91_RS08985 ENOG41062T2 Acyl carrier protein DXX91_RS08990 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DXX91_RS08995 ENOG4108MGH Enoyl-CoA hydratase DXX91_RS09000 ENOG4108KQ6 Enoyl-CoA hydratase DXX91_RS09005 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS09010 ENOG4107SQU synthase DXX91_RS09020 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS09030 ENOG4106A3M Cytochrome p-450 DXX91_RS09035 ENOG4105WFK nuclease DXX91_RS09040 ENOG4105XPP Protein of unknown function (DUF1275) DXX91_RS09050 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXX91_RS09060 ENOG4105K7W phage-related replication protein DXX91_RS09065 ENOG4108X3M OsmC Ohr family protein DXX91_RS09090 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DXX91_RS09115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXX91_RS09120 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXX91_RS09125 ENOG4105U6W MutT NUDIX family protein DXX91_RS09130 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXX91_RS09140 ENOG4106F1P AAA ATPase, central domain protein DXX91_RS09145 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DXX91_RS09150 ENOG4105CXI aluminum resistance protein DXX91_RS09155 ENOG4105KV4 Transcriptional regulator DXX91_RS09160 ENOG4105C5F glutamine synthetase DXX91_RS09170 ENOG4105CT4 transporter DXX91_RS09175 ENOG4105DSG hydrolase family 43 DXX91_RS09185 ENOG4105C93 Xylose Isomerase DXX91_RS09190 ENOG4105CMG Carbohydrate kinase DXX91_RS09195 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DXX91_RS09220 ENOG4105DQ4 alcohol dehydrogenase DXX91_RS09230 ENOG4105EPI acetyltransferase, (GNAT) family DXX91_RS09255 ENOG4108M1A Chitin-binding protein DXX91_RS09275 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DXX91_RS09280 ENOG4105K7W phage-related replication protein DXX91_RS09300 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DXX91_RS09310 ENOG4108SVB resolvase DXX91_RS09315 ENOG4105VPS UPF0291 protein DXX91_RS09320 ENOG4105CV1 Transketolase (EC 2.2.1.1) DXX91_RS09330 ENOG4105VXM UPF0154 protein DXX91_RS09340 ENOG4107QIV Cytochrome c biogenesis protein DXX91_RS09375 ENOG4108I0Z Aconitate hydratase DXX91_RS09380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXX91_RS09395 ENOG41067CD Small, acid-soluble spore protein Tlp DXX91_RS09405 ENOG4105MI2 DXX91_RS09410 ENOG4105W8X HesB YadR YfhF-family protein DXX91_RS09415 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DXX91_RS09420 ENOG4105K4P CoA-binding domain protein DXX91_RS09425 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXX91_RS09450 ENOG4105CPQ Dehydrogenase DXX91_RS09455 ENOG4108UHU Aldolase DXX91_RS09460 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DXX91_RS09465 ENOG4105DMW Dehydrogenase reductase DXX91_RS09475 ENOG4108I5G Major Facilitator superfamily DXX91_RS09490 ENOG4105FVX DXX91_RS09530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXX91_RS09540 ENOG4107SYN Glycosyl hydrolases family 43 DXX91_RS09570 ENOG4105DTD Dehydrogenase DXX91_RS09575 ENOG4108IIH CoA-transferase subunit B DXX91_RS09580 ENOG4105D6N CoA-transferase, subunit a DXX91_RS09585 ENOG4105CY2 Citrate transporter DXX91_RS09590 ENOG4106A3M Cytochrome p-450 DXX91_RS09595 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DXX91_RS09600 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DXX91_RS09605 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXX91_RS09610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXX91_RS09615 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) DXX91_RS09625 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXX91_RS09630 ENOG4107T5V SNARE associated Golgi DXX91_RS09635 ENOG4107QX3 carboxylase DXX91_RS09640 ENOG4105E39 Enoyl-CoA hydratase DXX91_RS09645 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DXX91_RS09650 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DXX91_RS09655 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXX91_RS09660 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS09665 ENOG4105C1G acyl-Coa dehydrogenase DXX91_RS09670 ENOG4105F32 YngK protein DXX91_RS09675 ENOG4106U2H Protein of unknown function (DUF1360) DXX91_RS09685 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS09690 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS09700 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS09710 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DXX91_RS09715 ENOG4108N2V aldose 1-epimerase DXX91_RS09745 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXX91_RS09750 ENOG4108RWP Major Facilitator Superfamily protein DXX91_RS09755 ENOG4105WAB arsR family transcriptional regulator DXX91_RS09765 ENOG4108KSA LysR family transcriptional regulator DXX91_RS09770 ENOG4105CB2 alcohol dehydrogenase DXX91_RS09775 ENOG4105BZ8 glutamate synthase DXX91_RS09780 ENOG4105CBC glutamate synthase DXX91_RS09785 ENOG4105C5Q Transcriptional regulator DXX91_RS09790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXX91_RS09815 ENOG4108UB7 DXX91_RS09820 ENOG4105IE8 Alpha-ketoglutarate permease DXX91_RS09825 ENOG4107U6E carbohydrate kinase FGGY DXX91_RS09830 ENOG4108M3J Dehydrogenase DXX91_RS09835 ENOG4108J2R molybdopterin oxidoreductase DXX91_RS09860 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DXX91_RS09870 ENOG4108Z7R Chaperone CsaA DXX91_RS09875 ENOG4105FTV AraC Family Transcriptional Regulator DXX91_RS09885 ENOG4108W8B Beta-lactamase domain protein DXX91_RS09895 ENOG4105KTU Transcriptional regulator, arsr family DXX91_RS09905 ENOG4108SJC Membrane DXX91_RS09930 ENOG41069ER domain protein DXX91_RS09935 ENOG4105C9U ATP-dependent DNA helicase RecQ DXX91_RS09945 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXX91_RS09950 ENOG4105SCY DNAK suppressor DXX91_RS09995 ENOG4105C26 Dehydrogenase DXX91_RS10000 ENOG4105EWU Squalene--hopene cyclase DXX91_RS10005 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXX91_RS10010 ENOG4105C8J )-transporter DXX91_RS10015 ENOG4105C09 Bile acid DXX91_RS10025 ENOG4105C7S Dehydrogenase DXX91_RS10030 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DXX91_RS10035 ENOG4107T89 von Willebrand factor, type A DXX91_RS10040 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DXX91_RS10050 ENOG4105K4H Nlp p60 protein DXX91_RS10055 ENOG41087PP glycosyltransferase MGT family DXX91_RS10065 ENOG4107QMU Mate efflux family protein DXX91_RS10070 ENOG4106SCS STAS domain DXX91_RS10090 ENOG4105FR1 rard protein DXX91_RS10105 ENOG41090U3 tautomerase DXX91_RS10125 ENOG4105FBA Phospholipase Carboxylesterase DXX91_RS10140 ENOG4105E1V na solute symporter DXX91_RS10155 ENOG4105CS2 ec 3.2.1.21 DXX91_RS10160 ENOG4108S3Y transcriptional regulator DXX91_RS10180 ENOG4108VXD carboxy-peptidase DXX91_RS10185 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DXX91_RS10195 ENOG4106Z5R DXX91_RS10200 ENOG410841Q phosphoesterase PA-phosphatase related protein DXX91_RS10235 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DXX91_RS10240 ENOG4108TSC N-acetyltransferase DXX91_RS10245 ENOG4107S4Y M20 DapE family protein YgeY DXX91_RS10260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXX91_RS10265 ENOG4105FTQ Dna gyrase DXX91_RS10405 ENOG4106ANW SMI1_KNR4 DXX91_RS10410 ENOG4106BHF DXX91_RS10420 ENOG4107Y9E nuclease DXX91_RS10450 ENOG4105E0X reductase DXX91_RS10455 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DXX91_RS10465 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) DXX91_RS10470 ENOG41090WU lipolytic protein G-D-S-L family DXX91_RS10475 ENOG4108KF3 Electron transport protein SCO1 SenC DXX91_RS10485 ENOG4105C7B Threonine dehydratase DXX91_RS10495 ENOG4108UT2 hemolysin iii DXX91_RS10505 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DXX91_RS10510 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DXX91_RS10520 ENOG4107YX5 Pfam:DUF548 DXX91_RS10525 ENOG4108Y6J UPF0403 protein DXX91_RS10530 ENOG4105C01 Dihydroxy-acid dehydratase DXX91_RS10545 ENOG4108V06 Glutathione peroxidase DXX91_RS10550 ENOG4105CVG Homoserine O-transsuccinylase DXX91_RS10590 ENOG41081VK Ribonuclease DXX91_RS10615 ENOG410890F Dynamin family DXX91_RS10630 ENOG41065KQ synthase DXX91_RS10665 ENOG4105C2W permease DXX91_RS10670 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DXX91_RS10675 ENOG4105CTD carboxy-peptidase DXX91_RS10680 ENOG4105DVT helicase DXX91_RS10695 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DXX91_RS10705 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DXX91_RS10710 ENOG4108UKS UPF0398 protein DXX91_RS10720 ENOG4107X2U Inherit from COG: Exonuclease-like protein DXX91_RS10725 ENOG4108I5C dEAD DEAH box helicase DXX91_RS10770 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) DXX91_RS10775 ENOG4105BZ4 penicillin-binding protein DXX91_RS10785 ENOG4105CSM endonuclease III DXX91_RS10795 ENOG4105C5S asparaginyl-tRNA synthetase DXX91_RS10800 ENOG4105CHM Aminotransferase DXX91_RS10810 ENOG4105YAC DXX91_RS10815 ENOG4105DVT helicase DXX91_RS10820 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DXX91_RS10830 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DXX91_RS10840 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DXX91_RS10845 ENOG4105CPK Glycosyl transferase (Group 1 DXX91_RS10850 ENOG4105FJR Lmbe family DXX91_RS10855 ENOG4108Z5K methylglyoxal synthase DXX91_RS10860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DXX91_RS10865 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DXX91_RS10870 ENOG4108JYZ YitT family DXX91_RS10875 ENOG4105F0F Oxalate decarboxylase DXX91_RS10895 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DXX91_RS10915 ENOG41068YB TPR repeat-containing protein DXX91_RS10920 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DXX91_RS10930 ENOG4105CIH Imidazole acetol-phosphate transaminase DXX91_RS10940 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DXX91_RS10945 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DXX91_RS10950 ENOG4105DK0 Indole-3-glycerol phosphate synthase DXX91_RS10960 ENOG4105CRQ synthase (Component I) DXX91_RS10965 ENOG4105KHN chorismate mutase DXX91_RS10975 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DXX91_RS10980 ENOG4105BZU Histidine kinase DXX91_RS10985 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DXX91_RS10990 ENOG4105EAH synthase DXX91_RS10995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DXX91_RS11000 ENOG4105XXQ heptaprenyl diphosphate synthase component I DXX91_RS11005 ENOG4105WP2 Tryptophan RNA-binding attenuator protein DXX91_RS11010 ENOG4105EUJ GTP cyclohydrolase i DXX91_RS11015 ENOG4105K70 DNA-binding protein DXX91_RS11020 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DXX91_RS11035 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DXX91_RS11040 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DXX91_RS11060 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DXX91_RS11065 ENOG4105CAT Cytidine monophosphate kinase DXX91_RS11075 ENOG4105MSI germination protein ypeb DXX91_RS11085 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DXX91_RS11090 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DXX91_RS11105 ENOG4107RGJ metallophosphoesterase DXX91_RS11120 ENOG4105I7S Abortive infection protein DXX91_RS11125 ENOG4105C9U ATP-dependent DNA helicase RecQ DXX91_RS11130 ENOG4105T7X DXX91_RS11140 ENOG4108SAX Membrane DXX91_RS11145 ENOG4108JQ1 Dehydrogenase DXX91_RS11160 ENOG4105BZU Histidine kinase DXX91_RS11165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS11170 ENOG4105CRE cytochrome C DXX91_RS11175 ENOG4107TWT Cytochrome c biogenesis protein DXX91_RS11185 ENOG4105FE9 pseudouridine synthase DXX91_RS11195 ENOG4108JIC nucleoside recognition domain protein DXX91_RS11200 ENOG4105DZ1 carboxypeptidase DXX91_RS11210 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DXX91_RS11215 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DXX91_RS11240 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DXX91_RS11245 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DXX91_RS11250 ENOG4108R6K riboflavin synthase, subunit alpha DXX91_RS11275 ENOG4107ZE5 PPIases accelerate the folding of proteins DXX91_RS11280 ENOG4105PTM secreted protein DXX91_RS11285 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DXX91_RS11295 ENOG4105G6R Stage v sporulation protein ae DXX91_RS11305 ENOG4105CZ3 stage V sporulation protein ad DXX91_RS11310 ENOG41090VF Stage v sporulation protein ac DXX91_RS11325 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS11330 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXX91_RS11335 ENOG41082AN stage II sporulation protein DXX91_RS11340 ENOG4105DZ1 carboxypeptidase DXX91_RS11345 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DXX91_RS11350 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DXX91_RS11355 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXX91_RS11365 ENOG4105I3K Ferric uptake regulator, Fur family DXX91_RS11370 ENOG4105MZ9 stage II sporulation protein m DXX91_RS11390 ENOG4105DFD Na H antiporter DXX91_RS11395 ENOG4108IJ0 Aspartate ammonia-lyase DXX91_RS11400 ENOG4105HDK L-asparaginase DXX91_RS11405 ENOG4108IMY Transcriptional regulator DXX91_RS11415 ENOG4108YZ4 nudix hydrolase DXX91_RS11425 ENOG4105CPC Aldo Keto reductase DXX91_RS11445 ENOG4106HZJ DXX91_RS11450 ENOG4105RHY Pfam:UPF0157 DXX91_RS11455 ENOG4105KAC Antibiotic biosynthesis monooxygenase DXX91_RS11460 ENOG4108XET gCN5-related N-acetyltransferase DXX91_RS11465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXX91_RS11480 ENOG4105C02 permease DXX91_RS11490 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase DXX91_RS11495 ENOG4105CS9 pantothenic acid kinase DXX91_RS11505 ENOG4108IXY short-chain dehydrogenase reductase DXX91_RS11510 ENOG41069FQ Metallo-beta-lactamase superfamily DXX91_RS11515 ENOG4105II7 pyrroline-5-carboxylate reductase DXX91_RS11520 ENOG4108KQ6 Enoyl-CoA hydratase DXX91_RS11525 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DXX91_RS11530 ENOG4106A3M Cytochrome p-450 DXX91_RS11545 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS11550 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS11560 ENOG4105C0W non-ribosomal peptide synthetase DXX91_RS11570 ENOG4105CHR reductase DXX91_RS11575 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS11590 ENOG4107QKG PfaD family DXX91_RS11600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DXX91_RS11610 ENOG4108K70 Transcriptional regulator DXX91_RS11620 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXX91_RS11630 ENOG410861F 50S ribosomal protein L33 DXX91_RS11635 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DXX91_RS11640 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DXX91_RS11645 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DXX91_RS11650 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXX91_RS11660 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) DXX91_RS11665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXX91_RS11670 ENOG4108HNZ carboxyl transferase DXX91_RS11675 ENOG4108ZVT methylmalonyl-coA epimerase DXX91_RS11680 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DXX91_RS11685 ENOG4108QEG Membrane DXX91_RS11690 ENOG4105CDA abc transporter atp-binding protein DXX91_RS11695 ENOG4105E5Q amino acid AbC transporter DXX91_RS11700 ENOG4108HW3 (ABC) transporter DXX91_RS11705 ENOG4108Y6J UPF0403 protein DXX91_RS11710 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DXX91_RS11715 ENOG4105C7S Dehydrogenase DXX91_RS11720 ENOG4105CPP Dehydrogenase, E1 component DXX91_RS11735 ENOG4105CKM Branched-chain carboxylic acid kinase DXX91_RS11740 ENOG4107RDP Dehydrogenase DXX91_RS11750 ENOG4108JUB Transcriptional regulator DXX91_RS11755 ENOG4106CCJ Protein of unknown function (DUF2627) DXX91_RS11760 ENOG4105CR4 methylisocitrate lyase DXX91_RS11765 ENOG4105DXD 2-methylcitrate dehydratase DXX91_RS11775 ENOG4105C1G acyl-Coa dehydrogenase DXX91_RS11780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DXX91_RS11790 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXX91_RS11795 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXX91_RS11815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXX91_RS11830 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXX91_RS11835 ENOG4107QQR Sporulation DXX91_RS11840 ENOG4105S1Z Stage IV sporulation protein B DXX91_RS11845 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DXX91_RS11850 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DXX91_RS11855 ENOG4105DX0 Hemolysin A DXX91_RS11860 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DXX91_RS11865 ENOG4105CTB Polyprenyl synthetase DXX91_RS11870 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXX91_RS11875 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXX91_RS11880 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DXX91_RS11885 ENOG4105M7K Involved in the transcription termination process (By similarity) DXX91_RS11890 ENOG4108ZSR alkaline shock protein DXX91_RS11895 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXX91_RS11915 ENOG410644B Stage III sporulation protein af DXX91_RS11925 ENOG4105KQ4 Stage iii sporulation protein ad DXX91_RS11930 ENOG4108CQH stage III sporulation protein AC DXX91_RS11935 ENOG4105KR5 Stage iii sporulation protein DXX91_RS11940 ENOG4105CD2 stage iii sporulation protein aa DXX91_RS11950 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DXX91_RS11955 ENOG4105DC7 peptidase M24 DXX91_RS11965 ENOG4105CBJ Metal-dependent enzyme DXX91_RS11985 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DXX91_RS11990 ENOG4105WZW rhodanese family DXX91_RS11995 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DXX91_RS12005 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DXX91_RS12010 ENOG4105C0D helicase DXX91_RS12025 ENOG4108IMY Transcriptional regulator DXX91_RS12035 ENOG4105VFR signal peptidase DXX91_RS12095 ENOG4105C37 (CBS) domain DXX91_RS12120 ENOG4105C5X domain protein DXX91_RS12165 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DXX91_RS12180 ENOG41068DG YceG-like family DXX91_RS12185 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXX91_RS12190 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXX91_RS12195 ENOG4105E2Z phosphate ABC transporter (Permease DXX91_RS12200 ENOG4105C8U phosphate abc transporter DXX91_RS12205 ENOG4105CVA phosphate DXX91_RS12210 ENOG4107RF6 penicillin-binding protein DXX91_RS12220 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXX91_RS12225 ENOG4105SXS Protein of unknown function (DUF456) DXX91_RS12240 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DXX91_RS12245 ENOG41063Y9 DXX91_RS12250 ENOG4108U5J '-nucleotidase DXX91_RS12255 ENOG4105N80 Ferric uptake regulator, Fur family DXX91_RS12260 ENOG4108JYZ YitT family DXX91_RS12265 ENOG41069ZM Protein of unknown function (DUF2624) DXX91_RS12270 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DXX91_RS12285 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DXX91_RS12290 ENOG4105EGD dinuclear metal center protein, YbgI family DXX91_RS12305 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS12310 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DXX91_RS12315 ENOG4108UPT UPF0178 protein DXX91_RS12320 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DXX91_RS12330 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DXX91_RS12335 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DXX91_RS12340 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DXX91_RS12350 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DXX91_RS12355 ENOG4105KG3 cytidine deaminase DXX91_RS12360 ENOG4107YR5 Diacylglycerol kinase DXX91_RS12365 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DXX91_RS12370 ENOG4105CTJ Metal Dependent Phosphohydrolase DXX91_RS12375 ENOG4105C9A Phoh family DXX91_RS12380 ENOG4105EI1 sporulation protein yqfd DXX91_RS12385 ENOG41068P3 sporulation protein YqfC DXX91_RS12395 ENOG4105DI5 UPF0365 protein DXX91_RS12400 ENOG4105F7J membrane-bound serine protease DXX91_RS12405 ENOG4105KTH gatB Yqey DXX91_RS12420 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXX91_RS12425 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DXX91_RS12430 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DXX91_RS12435 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DXX91_RS12440 ENOG4105CFG Acts as a chaperone (By similarity) DXX91_RS12445 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DXX91_RS12450 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DXX91_RS12455 ENOG4105CSA Coproporphyrinogen iii oxidase DXX91_RS12460 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DXX91_RS12470 ENOG4108ZRV stage ii sporulation protein p DXX91_RS12475 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DXX91_RS12480 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DXX91_RS12485 ENOG4105TQK DNA polymerase iii, delta' subunit DXX91_RS12495 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DXX91_RS12500 ENOG4108UK2 deaminase DXX91_RS12505 ENOG4105KQC Competence protein DXX91_RS12515 ENOG4108D32 Methyltransferase DXX91_RS12525 ENOG4108WF2 Metal Dependent Phosphohydrolase DXX91_RS12530 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DXX91_RS12535 ENOG410812S Rna-binding protein DXX91_RS12540 ENOG4105E2X shikimate dehydrogenase DXX91_RS12545 ENOG4105CQW ribosome biogenesis GTPase YqeH DXX91_RS12550 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DXX91_RS12570 ENOG41080BT SNARE associated Golgi DXX91_RS12585 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS12600 ENOG41086D8 Transcriptional regulator DXX91_RS12610 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DXX91_RS12620 ENOG4108J8C transporter major facilitator family protein DXX91_RS12630 ENOG4108U7W acetyltransferase DXX91_RS12645 ENOG4105DQF Hydrolase DXX91_RS12660 ENOG4105DG6 mannose-6-phosphate isomerase DXX91_RS12665 ENOG4105DM4 PTS System DXX91_RS12680 ENOG4108Z66 YbaK ebsC protein DXX91_RS12685 ENOG4107RSM transcriptional regulator DXX91_RS12690 ENOG4105D94 Major Facilitator Superfamily DXX91_RS12695 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXX91_RS12700 ENOG41082JN Transcriptional regulator DXX91_RS12720 ENOG4105TMB Formate nitrite transporter DXX91_RS12725 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DXX91_RS12730 ENOG4108JB9 formate dehydrogenase DXX91_RS12745 ENOG4105C28 cystathionine DXX91_RS12775 ENOG4107XRG penicillin-binding protein DXX91_RS12780 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DXX91_RS12790 ENOG4105CFP Peptidase U32 DXX91_RS12795 ENOG4105XYU peptidase (U32 family) DXX91_RS12805 ENOG4105HHA aminodeoxychorismate lyase DXX91_RS12815 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DXX91_RS12820 ENOG4105VBH UPF0297 protein DXX91_RS12825 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DXX91_RS12830 ENOG4105C02 permease DXX91_RS12835 ENOG4105CDA abc transporter atp-binding protein DXX91_RS12840 ENOG4105CT1 (ABC) transporter DXX91_RS12845 ENOG4105EAD ABC transporter DXX91_RS12850 ENOG4105DRP amino acid AbC transporter DXX91_RS12860 ENOG41060CR DXX91_RS12870 ENOG4105C7H Helicase, RecD TraA family DXX91_RS12880 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DXX91_RS12885 ENOG4105C3J Cysteine desulfurase DXX91_RS12895 ENOG4105D1H recombination factor protein RarA DXX91_RS12900 ENOG4105CUZ uba thif-type nad fad binding protein DXX91_RS12910 ENOG4105C9M aspartyl-trna synthetase DXX91_RS12915 ENOG4105CUT histidyl-tRNA synthetase DXX91_RS12920 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXX91_RS12925 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DXX91_RS12930 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DXX91_RS12940 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DXX91_RS12945 ENOG41067VP Protein of unknown function (DUF1049) DXX91_RS12950 ENOG4105NCW Trka-c domain protein DXX91_RS12955 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DXX91_RS12965 ENOG4105CKP Polysaccharide Biosynthesis Protein DXX91_RS12970 ENOG4108QG2 Membrane DXX91_RS12975 ENOG4105NAP DXX91_RS12980 ENOG4105VIE preprotein translocase, subunit YajC DXX91_RS12985 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DXX91_RS12990 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DXX91_RS12995 ENOG41061AI Protein of unknown function (DUF2905) DXX91_RS13000 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DXX91_RS13005 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DXX91_RS13025 ENOG4106678 morphogenetic protein associated with SpoVID DXX91_RS13030 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DXX91_RS13035 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DXX91_RS13040 ENOG4108IYU L-aspartate oxidase DXX91_RS13055 ENOG4105CQC Prephenate dehydratase DXX91_RS13065 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DXX91_RS13075 ENOG4105K46 50S ribosomal protein l27 DXX91_RS13080 ENOG4105X36 (ribosomal) protein DXX91_RS13085 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DXX91_RS13100 ENOG4107QMS site-determining protein DXX91_RS13105 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DXX91_RS13110 ENOG4105YHC Rod shape-determining protein MreD DXX91_RS13120 ENOG4105DFF Rod shape-determining protein mreb DXX91_RS13125 ENOG4105W5Q DNA repair protein (RadC DXX91_RS13130 ENOG4108Z03 MAF-like protein DXX91_RS13140 ENOG4106A3R peptidase DXX91_RS13145 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DXX91_RS13150 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DXX91_RS13160 ENOG4106AR7 Spore coat protein DXX91_RS13165 ENOG41068KH stage VI sporulation protein D DXX91_RS13170 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DXX91_RS13175 ENOG4105D52 delta-aminolevulinic acid dehydratase DXX91_RS13185 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DXX91_RS13195 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DXX91_RS13205 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DXX91_RS13210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DXX91_RS13215 ENOG4108IUQ atp-dependent protease DXX91_RS13220 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DXX91_RS13225 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DXX91_RS13235 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXX91_RS13240 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXX91_RS13245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXX91_RS13255 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DXX91_RS13260 ENOG4108ZP8 Acetolactate synthase small subunit DXX91_RS13265 ENOG4105C7K acetolactate synthase DXX91_RS13290 ENOG4105M59 Phosphodiesterase, mj0936 family DXX91_RS13295 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DXX91_RS13300 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DXX91_RS13305 ENOG4108XJQ germination protein DXX91_RS13310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DXX91_RS13315 ENOG41067TZ transcriptional regulator, MarR family DXX91_RS13320 ENOG4105PFC Transcriptional regulator DXX91_RS13330 ENOG4105E33 succinate dehydrogenase DXX91_RS13340 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DXX91_RS13350 ENOG4105CFH Aspartokinase DXX91_RS13360 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DXX91_RS13365 ENOG4105K63 Thioredoxin DXX91_RS13370 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXX91_RS13375 ENOG4105C10 Electron transfer flavoprotein DXX91_RS13380 ENOG4105BZJ Electron transfer flavoprotein DXX91_RS13385 ENOG41060WC Enoyl-CoA hydratase DXX91_RS13390 ENOG4107Z3H Transcriptional regulator, TetR family DXX91_RS13395 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS13400 ENOG4108YV3 Protein of unknown function (DUF2711) DXX91_RS13410 ENOG4105C98 muts2 protein DXX91_RS13415 ENOG4105DCG PHP domain protein DXX91_RS13430 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXX91_RS13435 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DXX91_RS13440 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DXX91_RS13445 ENOG4108RWN rrna methyltransferase DXX91_RS13450 ENOG41067MF small acid-soluble spore protein DXX91_RS13460 ENOG4105CQB FAD linked oxidase domain protein DXX91_RS13465 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXX91_RS13475 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXX91_RS13480 ENOG4105DRS transport system, permease DXX91_RS13495 ENOG4108MDK Dehydrogenase DXX91_RS13505 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase DXX91_RS13510 ENOG4105EF1 ribulokinase DXX91_RS13520 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DXX91_RS13525 ENOG4105CN9 Peptidase m42 family protein DXX91_RS13535 ENOG410696E Membrane DXX91_RS13565 ENOG4105DY9 regulatoR DXX91_RS13570 ENOG4108HRK Histidine kinase DXX91_RS13585 ENOG4105C22 threonyL-tRNA synthetase DXX91_RS13590 ENOG4108TDW sporulation protein YtxC DXX91_RS13615 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DXX91_RS13620 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXX91_RS13625 ENOG4105KVH Transcriptional regulator DXX91_RS13630 ENOG4105F27 Major Facilitator DXX91_RS13635 ENOG4105CV8 reductase DXX91_RS13640 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DXX91_RS13650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DXX91_RS13655 ENOG4105C2M dna polymerase I DXX91_RS13660 ENOG4105BZU Histidine kinase DXX91_RS13665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXX91_RS13675 ENOG4108HMX isocitrate dehydrogenase (NADP) DXX91_RS13680 ENOG4105BZN citrate synthase DXX91_RS13685 ENOG4105G7B Protein of unknown function (DUF2992) DXX91_RS13700 ENOG4108REF Sporulation integral membrane protein ytvi DXX91_RS13705 ENOG4105FS0 cytoplasmic membrane protein DXX91_RS13710 ENOG4105CA9 Pyruvate kinase DXX91_RS13715 ENOG4105CTQ phosphohexokinase DXX91_RS13720 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DXX91_RS13725 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DXX91_RS13730 ENOG4105C6K Malic enzyme DXX91_RS13735 ENOG4105C0B DNA polymerase III (alpha subunit) DXX91_RS13740 ENOG4105VV2 DXX91_RS13750 ENOG4106EVM DXX91_RS13755 ENOG4105SFS phosphoesterase RecJ domain protein DXX91_RS13770 ENOG4105E8R UPF0173 metal-dependent hydrolase DXX91_RS13780 ENOG4105CH7 arginosuccinase DXX91_RS13785 ENOG4105CDH Citrulline--aspartate ligase DXX91_RS13790 ENOG4105EPU Molybdenum cofactor synthesis domain protein DXX91_RS13795 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DXX91_RS13805 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DXX91_RS13810 ENOG4105KBJ sporulation protein ytfj DXX91_RS13820 ENOG4105VK3 rdd domain containing protein DXX91_RS13825 ENOG4105D07 Signal peptide peptidase, SppA DXX91_RS13830 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXX91_RS13835 ENOG4105EFZ amidohydrolase DXX91_RS13840 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DXX91_RS13850 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DXX91_RS13875 ENOG4105U5Y Transcriptional regulator DXX91_RS13885 ENOG4105BZU Histidine kinase DXX91_RS13895 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DXX91_RS13900 ENOG4105C26 Dehydrogenase DXX91_RS13915 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DXX91_RS13925 ENOG4108Z0Z intracellular protease Pfpi family DXX91_RS13945 ENOG4108NGU Transcriptional regulator DXX91_RS13960 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DXX91_RS13975 ENOG4105F1V Acetoin utilization protein DXX91_RS13980 ENOG4105W87 Cbs domain DXX91_RS13985 ENOG4105DGU Histone deacetylase DXX91_RS13990 ENOG4105ER2 Ompa motb domain protein DXX91_RS13995 ENOG4107R0U MotA TolQ exbB proton channel DXX91_RS14000 ENOG4105ETE Transcriptional regulator (LacI family DXX91_RS14005 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DXX91_RS14025 ENOG4105DFU Cell wall formation (By similarity) DXX91_RS14035 ENOG4108VDD TRNA binding domain protein DXX91_RS14050 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DXX91_RS14065 ENOG4105C6K Malic enzyme DXX91_RS14070 ENOG4105C8F Beta-lactamase domain protein DXX91_RS14075 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DXX91_RS14085 ENOG4108V15 phosphotransferase enzyme family DXX91_RS14100 ENOG4107F58 2'-5' rna ligase DXX91_RS14105 ENOG4105C6T cysteine synthase DXX91_RS14110 ENOG4107QSE Dipeptidase DXX91_RS14115 ENOG4105C7N Xanthine uracil vitamin C permease DXX91_RS14130 ENOG4105YW5 deoR family transcriptional regulator DXX91_RS14145 ENOG4105CBX hi0933 family DXX91_RS14150 ENOG4105C94 Transporter DXX91_RS14190 ENOG41085GJ domain protein DXX91_RS14195 ENOG4105C8T Leucyl-tRNA synthetase DXX91_RS14205 ENOG4105BZU Histidine kinase DXX91_RS14210 ENOG410605W Major Facilitator DXX91_RS14225 ENOG4105C19 ABC transporter DXX91_RS14230 ENOG4105EWM Histidine kinase DXX91_RS14240 ENOG4107R34 abc transporter permease protein DXX91_RS14245 ENOG4105C19 ABC transporter DXX91_RS14265 ENOG4105DVE abc transporter atp-binding protein DXX91_RS14270 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DXX91_RS14280 ENOG4105N5T Radical SAM Protein DXX91_RS14295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DXX91_RS14305 ENOG4105E8V Alpha Beta Hydrolase Fold protein DXX91_RS14310 ENOG4108Z0R Transferase DXX91_RS14315 ENOG4105C85 amino acid DXX91_RS14320 ENOG4105CAQ asparagine synthetase DXX91_RS14325 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DXX91_RS14330 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DXX91_RS14345 ENOG4105D2X ABC transporter substrate-binding protein DXX91_RS14355 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DXX91_RS14370 ENOG4108RMU ferritin dps family protein DXX91_RS14385 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DXX91_RS14390 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DXX91_RS14395 ENOG4108V2W Carbonate dehydratase DXX91_RS14400 ENOG4105NRA 50s ribosomal protein l31 type b DXX91_RS14425 ENOG4105DTQ mandelate racemase muconate lactonizing DXX91_RS14430 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS14435 ENOG4108IPT Naphthoate synthase DXX91_RS14440 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DXX91_RS14445 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DXX91_RS14450 ENOG4105E4F Isochorismate synthase DXX91_RS14585 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DXX91_RS14590 ENOG4105DZ6 Band 7 protein DXX91_RS14600 ENOG4106DF1 DXX91_RS14605 ENOG4108VNY MOSC domain protein DXX91_RS14610 ENOG4108JB8 alcohol dehydrogenase DXX91_RS14620 ENOG4105TRT Transcriptional regulator DXX91_RS14635 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DXX91_RS14640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DXX91_RS14680 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DXX91_RS14690 ENOG4105EE0 oxidoreductase DXX91_RS14695 ENOG4108Z0Z intracellular protease Pfpi family DXX91_RS14700 ENOG4105C8Q Methyl-accepting chemotaxis DXX91_RS14705 ENOG4105C8Q Methyl-accepting chemotaxis DXX91_RS14710 ENOG4105C8Q Methyl-accepting chemotaxis DXX91_RS14715 ENOG4105C8Q Methyl-accepting chemotaxis DXX91_RS14730 ENOG4105EA8 2-Nitropropane dioxygenase DXX91_RS14735 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DXX91_RS14745 ENOG4105C37 (CBS) domain DXX91_RS14760 ENOG4107PBV potassium channel DXX91_RS14765 ENOG4107PBV potassium channel DXX91_RS14780 ENOG4107QYV phosphohexose isomerase DXX91_RS14795 ENOG4105CHJ isochorismatase hydrolase DXX91_RS14810 ENOG4107QW4 alcohol dehydrogenase DXX91_RS14815 ENOG4105WG9 Conserved Protein DXX91_RS14825 ENOG4105CHM Aminotransferase DXX91_RS14830 ENOG4108ZB6 transcriptional regulator AsnC family DXX91_RS14835 ENOG4108MUZ hydrolase DXX91_RS14845 ENOG4105C87 Aminotransferase class I and II DXX91_RS14850 ENOG4108HGU Histidine kinase DXX91_RS14855 ENOG4105Y38 Kinase-associated protein B DXX91_RS14870 ENOG4105BZ4 penicillin-binding protein DXX91_RS14875 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DXX91_RS14890 ENOG4108MRH transcriptional regulatory protein DXX91_RS14895 ENOG4105DIH basic membrane DXX91_RS14900 ENOG4108JQ9 ABC transporter DXX91_RS14905 ENOG4105UIB (ABC) transporter DXX91_RS14920 ENOG4105D65 subunit l DXX91_RS14925 ENOG4105HC0 Na H antiporter DXX91_RS14930 ENOG4108ZE9 Monovalent cation H antiporter subunit C DXX91_RS14935 ENOG4108JPZ Monovalent cation H antiporter subunit D DXX91_RS14940 ENOG4105SC1 monovalent cation H antiporter subunit E DXX91_RS14950 ENOG4105KJM monovalent cation h antiporter subunit g DXX91_RS14955 ENOG4105KA0 thioesterase Superfamily protein DXX91_RS14990 ENOG4105D58 Diguanylate phosphodiesterase DXX91_RS14995 ENOG4105DAP Nicotinate phosphoribosyltransferase DXX91_RS15020 ENOG4105C02 permease DXX91_RS15035 ENOG410904N short-chain dehydrogenase reductase DXX91_RS15070 ENOG4108K8K Transcriptional regulator DXX91_RS15075 ENOG4105DCF alanine dehydrogenase DXX91_RS15085 ENOG4105WQT MbtH domain protein DXX91_RS15090 ENOG4105CEY Amp-dependent synthetase and ligase DXX91_RS15095 ENOG4105WQI isochorismatase DXX91_RS15100 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DXX91_RS15105 ENOG4105E4F Isochorismate synthase DXX91_RS15110 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DXX91_RS15115 ENOG4105NIV Esterase DXX91_RS15135 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DXX91_RS15145 ENOG41069ER domain protein DXX91_RS15160 ENOG4105CEP NADH dehydrogenase DXX91_RS15175 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DXX91_RS15190 ENOG4105CJ1 ABC, transporter DXX91_RS15215 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DXX91_RS15220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DXX91_RS15225 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DXX91_RS15235 ENOG4105ZKE UPF0349 protein DXX91_RS15250 ENOG41083MR nifu domain-containing protein DXX91_RS15255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DXX91_RS15260 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DXX91_RS15265 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DXX91_RS15270 ENOG4105D6E homoserine dehydrogenase DXX91_RS15280 ENOG4108W5N phosphatidylglycerophosphatase a DXX91_RS15285 ENOG4105D4U had-superfamily hydrolase, subfamily iia DXX91_RS15295 ENOG4105MMD transcriptional regulator DXX91_RS15305 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DXX91_RS15310 ENOG4105FAA peptidase M23 DXX91_RS15315 ENOG4108YTE sporulation protein YunB DXX91_RS15320 ENOG4107R8B 5'-nucleotidase DXX91_RS15330 ENOG4105I3N Conserved Protein DXX91_RS15340 ENOG4105CD3 dihydroorotase DXX91_RS15345 ENOG4105G9B Transcriptional regulator DXX91_RS15380 ENOG4105C5R Aminotransferase DXX91_RS15390 ENOG4108K8S endonuclease I DXX91_RS15395 ENOG4108IJ9 (ABC) transporter DXX91_RS15400 ENOG4105FDP GntR family transcriptional regulator DXX91_RS15405 ENOG4108KPW sugar kinase DXX91_RS15410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DXX91_RS15415 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DXX91_RS15420 ENOG4105XN3 extracellular solute-binding protein family 1 DXX91_RS15425 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine DXX91_RS15435 ENOG4105PKS Excinuclease abc c subunit domain protein DXX91_RS15440 ENOG4107VFR oxidoreductase DXX91_RS15455 ENOG41083Q9 chitosanase DXX91_RS15460 ENOG4105DIW FeS assembly protein SUFB DXX91_RS15465 ENOG4108UNV SUF system FeS assembly protein, NifU family DXX91_RS15470 ENOG4105C9B Cysteine desulfurase DXX91_RS15475 ENOG4105JRK feS assembly protein SufD DXX91_RS15480 ENOG4105C3K feS assembly ATPase SufC DXX91_RS15495 ENOG4105D01 (LipO)protein DXX91_RS15500 ENOG4108UMI ABC transporter, permease DXX91_RS15505 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DXX91_RS15530 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DXX91_RS15535 ENOG41080E8 Transcriptional regulator, Spx MgsR family DXX91_RS15540 ENOG4105C1G acyl-Coa dehydrogenase DXX91_RS15545 ENOG4105CHU acetyl-coa acetyltransferase DXX91_RS15575 ENOG41067TZ transcriptional regulator, MarR family DXX91_RS15580 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXX91_RS15585 ENOG4105C5Q Transcriptional regulator DXX91_RS15605 ENOG4105E0A ABC, transporter DXX91_RS15620 ENOG4105E1F short-chain dehydrogenase reductase DXX91_RS15625 ENOG4105HUF DNA protection during starvation protein DXX91_RS15630 ENOG4105C0H protease DXX91_RS15640 ENOG4105F3H Histidine kinase DXX91_RS15650 ENOG41067SE Tetr family transcriptional regulator DXX91_RS15655 ENOG4105C9Q fumarate hydratase class II DXX91_RS15680 ENOG4105WH1 Two component transcriptional regulator luxr family DXX91_RS15685 ENOG4105ENE Histidine kinase DXX91_RS15700 ENOG41087YS Phage shock protein A DXX91_RS15715 ENOG4108WBT adenosyltransferase DXX91_RS15720 ENOG4105E0A ABC, transporter DXX91_RS15725 ENOG4105EHG Permease protein DXX91_RS15730 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DXX91_RS15735 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXX91_RS15740 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DXX91_RS15750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXX91_RS15760 ENOG4106DF4 Sigma-70, region 4 DXX91_RS15770 ENOG4105F0F Oxalate decarboxylase DXX91_RS15780 ENOG4105E0A ABC, transporter DXX91_RS15785 ENOG4105EHG Permease protein DXX91_RS15790 ENOG4105DQ5 transport system permease protein DXX91_RS15800 ENOG4105JQZ Methyltransferase DXX91_RS15805 ENOG4105D5Q Arginine ornithine antiporter DXX91_RS15820 ENOG4107K5X Membrane-bound metal-dependent hydrolase DXX91_RS15825 ENOG4107QZ2 Sulfatase DXX91_RS15830 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DXX91_RS15835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DXX91_RS15840 ENOG4105E0C molybdate abc transporter DXX91_RS15845 ENOG4105WH1 Two component transcriptional regulator luxr family DXX91_RS15850 ENOG4105BZU Histidine kinase DXX91_RS15855 ENOG4105CJ1 ABC, transporter DXX91_RS15865 ENOG4108KYE ABC-2 type transporter DXX91_RS15880 ENOG4105EEQ Na H antiporter DXX91_RS15890 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DXX91_RS15895 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXX91_RS15900 ENOG4105EEM helicase DXX91_RS15905 ENOG4105EN6 Membrane DXX91_RS15920 ENOG4107ZQN disulfide bond DXX91_RS15925 ENOG4105C59 p-type ATPase DXX91_RS15930 ENOG4105C59 p-type ATPase DXX91_RS15935 ENOG410681U heavy metal transport detoxification protein DXX91_RS15940 ENOG4105VPX protein, conserved in bacteria DXX91_RS15945 ENOG4105D9R oxidoreductase DXX91_RS15950 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXX91_RS15965 ENOG4105DEN Luciferase family DXX91_RS15970 ENOG4105CDA abc transporter atp-binding protein DXX91_RS15995 ENOG4108XSB acetyltransferase, (GNAT) family DXX91_RS16000 ENOG4108KSA LysR family transcriptional regulator DXX91_RS16005 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXX91_RS16010 ENOG41067XF inhibitor DXX91_RS16020 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DXX91_RS16025 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DXX91_RS16035 ENOG4105XZU Preprotein translocase, subunit SecG DXX91_RS16055 ENOG4105KVH Transcriptional regulator DXX91_RS16080 ENOG4105DA5 (ABC) transporter DXX91_RS16085 ENOG4105R40 Glycine betaine carnitine choline DXX91_RS16090 ENOG4108HQR Glycine betaine DXX91_RS16095 ENOG4105E90 ABC transporter DXX91_RS16100 ENOG4108IJ8 ABC transporter DXX91_RS16105 ENOG4107HG4 Transcriptional regulator DXX91_RS16110 ENOG4105R40 Glycine betaine carnitine choline DXX91_RS16115 ENOG4108HQR Glycine betaine DXX91_RS16120 ENOG4105E90 ABC transporter DXX91_RS16125 ENOG4108IJ8 ABC transporter DXX91_RS16130 ENOG4107HG4 Transcriptional regulator DXX91_RS16135 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DXX91_RS16145 ENOG4105T65 Membrane-associated protein DXX91_RS16150 ENOG4108W0I acetyltransferase DXX91_RS16165 ENOG4105FJR Lmbe family DXX91_RS16180 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXX91_RS16185 ENOG4108IAJ Nad-dependent epimerase dehydratase DXX91_RS16190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXX91_RS16195 ENOG4107QQG Dehydrogenase DXX91_RS16200 ENOG4105IIU Aminopeptidase DXX91_RS16205 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DXX91_RS16210 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DXX91_RS16215 ENOG4105CP7 Triose-phosphate isomerase DXX91_RS16220 ENOG4105BZA Phosphoglycerate kinase DXX91_RS16230 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXX91_RS16245 ENOG4105CMD Transcriptional regulator, GntR family DXX91_RS16250 ENOG4105DEN Luciferase family DXX91_RS16260 ENOG4105GZI Transcriptional regulator DXX91_RS16265 ENOG4107RT3 EamA-like transporter family DXX91_RS16290 ENOG410667J hydrolase DXX91_RS16295 ENOG4106KNT transcriptional regulator DXX91_RS16300 ENOG4105CMG Carbohydrate kinase DXX91_RS16305 ENOG4105C6Z Gluconate DXX91_RS16315 ENOG4107QR9 Iron-sulfur cluster binding protein DXX91_RS16320 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXX91_RS16325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXX91_RS16330 ENOG4105JXH GntR family transcriptional regulator DXX91_RS16335 ENOG4105DAA L-lactate DXX91_RS16340 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXX91_RS16350 ENOG4108ZPC Polysaccharide pyruvyl transferase DXX91_RS16355 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXX91_RS16360 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family DXX91_RS16365 ENOG4105D3Q Sugar transferase DXX91_RS16375 ENOG4105K64 Glycosyl transferase, family 2 DXX91_RS16385 ENOG4107QRS glycosyltransferase group 2 family protein DXX91_RS16390 ENOG41068W6 Capsular polysaccharide biosynthesis protein DXX91_RS16395 ENOG4108KMV Glycosyl transferase (Group 1 DXX91_RS16400 ENOG4105K64 Glycosyl transferase, family 2 DXX91_RS16405 ENOG4108PQP glycosyl transferase group 1 DXX91_RS16415 ENOG4108QV3 biosynthesis protein DXX91_RS16420 ENOG4105HTX biosynthesis protein DXX91_RS16430 ENOG4105EBR Carboxylesterase DXX91_RS16440 ENOG4105NAE bifunctional deaminase-reductase domain protein DXX91_RS16450 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DXX91_RS16455 ENOG4105PY6 Phenolic acid decarboxylase DXX91_RS16460 ENOG4105NI3 Protein of unknown function (DUF3237) DXX91_RS16505 ENOG4108HKT sucrose-6-phosphate hydrolase DXX91_RS16510 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) DXX91_RS16515 ENOG4105ETE Transcriptional regulator (LacI family DXX91_RS16520 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DXX91_RS16525 ENOG4108KAM Transcriptional regulator DXX91_RS16530 ENOG4105C7F AcnD-accessory protein PrpF DXX91_RS16540 ENOG4108URH decarboxylase DXX91_RS16545 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DXX91_RS16550 ENOG4105CHH sulfate transporter DXX91_RS16555 ENOG4108V2W Carbonate dehydratase DXX91_RS16565 ENOG4105C5I Dehydrogenase DXX91_RS16570 ENOG4105GGE ribonuclease DXX91_RS16575 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DXX91_RS16580 ENOG4105KRI phosphocarrier protein (HPr DXX91_RS16585 ENOG4105CIE May be required for sporulation (By similarity) DXX91_RS16590 ENOG4105CHW UPF0052 protein DXX91_RS16595 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DXX91_RS16600 ENOG4108Z4K mutator MutT protein DXX91_RS16605 ENOG4105C3M thioredoxin reductase DXX91_RS16620 ENOG4105BZU Histidine kinase DXX91_RS16625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS16630 ENOG4105GIG DXX91_RS16635 ENOG4105BZ1 (ABC) transporter DXX91_RS16640 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DXX91_RS16645 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DXX91_RS16650 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DXX91_RS16655 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DXX91_RS16660 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DXX91_RS16665 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DXX91_RS16670 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DXX91_RS16675 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DXX91_RS16685 ENOG4108S4C acetyltransferase DXX91_RS16690 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DXX91_RS16700 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DXX91_RS16705 ENOG4105CE4 GlcNAc 6-P deacetylase DXX91_RS16710 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DXX91_RS16720 ENOG4105J7D transcriptional regulator DXX91_RS16725 ENOG41088CQ domain protein DXX91_RS16730 ENOG41086DT Membrane protein of unknown function DXX91_RS16735 ENOG41067S9 phage shock protein C, PspC DXX91_RS16740 ENOG4108PY7 DXX91_RS16755 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DXX91_RS16760 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DXX91_RS16825 ENOG4105CN1 protease DXX91_RS16830 ENOG4108M26 parallel beta-helix repeat protein DXX91_RS16835 ENOG4105CRP Part of the ABC transporter FtsEX involved in DXX91_RS16840 ENOG4105CAK Cell division ATP-binding protein ftsE DXX91_RS16860 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DXX91_RS16865 ENOG4105MS2 ribosomal subunit Interface protein DXX91_RS16880 ENOG4105MQ3 flagellar protein FliS DXX91_RS16885 ENOG4107RT6 flagellar hook-associated DXX91_RS16890 ENOG4105I03 Flagellin DXX91_RS16895 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DXX91_RS16900 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DXX91_RS16910 ENOG4105DTJ flagellar hook-associated protein DXX91_RS16915 ENOG4105E1Q flagellar hook-associated protein DXX91_RS16930 ENOG4105RU3 DXX91_RS16935 ENOG41081UC Inherit from COG: Competence protein DXX91_RS16955 ENOG4105WH1 Two component transcriptional regulator luxr family DXX91_RS16960 ENOG4105BZU Histidine kinase DXX91_RS16965 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DXX91_RS16970 ENOG4108KGH TRANSCRIPTIONal DXX91_RS16975 ENOG4105ESV Glycosyl transferase, family 4 DXX91_RS16980 ENOG4107EF8 Glycosyl transferase (Group 1 DXX91_RS16995 ENOG4105QZI O-Antigen Polymerase DXX91_RS17000 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXX91_RS17005 ENOG4107RA4 Glycosyl transferase (Group 1 DXX91_RS17010 ENOG4105PSV Polysaccharide Biosynthesis Protein DXX91_RS17015 ENOG4105D3Q Sugar transferase DXX91_RS17020 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXX91_RS17025 ENOG4105JFG SpoIID LytB domain protein DXX91_RS17040 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DXX91_RS17045 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXX91_RS17060 ENOG4107SJB teichoic acid biosynthesis DXX91_RS17070 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DXX91_RS17080 ENOG4107RZX Teichoic acid biosynthesis protein DXX91_RS17090 ENOG4105DG6 mannose-6-phosphate isomerase DXX91_RS17105 ENOG4108NHD germination protein DXX91_RS17110 ENOG4107R8N Glycosyl transferase, family 2 DXX91_RS17115 ENOG4105C54 Major Facilitator superfamily DXX91_RS17120 ENOG4108KGH TRANSCRIPTIONal DXX91_RS17125 ENOG4105J7I hydrolase DXX91_RS17130 ENOG4106UBQ DXX91_RS17135 ENOG4105K4H Nlp p60 protein DXX91_RS17145 ENOG4105PNM synthesis protein DXX91_RS17155 ENOG4105N98 Capsule biosynthesis protein capB DXX91_RS17180 ENOG4105ETE Transcriptional regulator (LacI family DXX91_RS17185 ENOG4108RVA ribokinase DXX91_RS17190 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DXX91_RS17195 ENOG4105C2J ABC transporter DXX91_RS17200 ENOG4105CNN ABC, transporter DXX91_RS17205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DXX91_RS17215 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXX91_RS17220 ENOG4107FQX Alpha-acetolactate decarboxylase DXX91_RS17230 ENOG4107RSM transcriptional regulator DXX91_RS17245 ENOG4106UIA DXX91_RS17270 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXX91_RS17280 ENOG4105CAH Chromate DXX91_RS17285 ENOG4105FGV Chromate DXX91_RS17295 ENOG4108WS4 fmn reductase DXX91_RS17300 ENOG4107V2S Transcriptional regulator DXX91_RS17305 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) DXX91_RS17335 ENOG4108XI2 Domain of unknown function (DUF1963) DXX91_RS17340 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXX91_RS17345 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DXX91_RS17350 ENOG4107YJ4 chain length determinant protein DXX91_RS17355 ENOG4105HTX biosynthesis protein DXX91_RS17370 ENOG4105KBK Zinc finger, swim domain protein DXX91_RS17375 ENOG4105C0D helicase DXX91_RS17380 ENOG410667J hydrolase DXX91_RS17385 ENOG4105E98 transcriptional regulator DeoR family DXX91_RS17390 ENOG4105Z8H single-stranded DNA-binding protein DXX91_RS17405 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DXX91_RS17410 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DXX91_RS17420 ENOG4105CGA flagellar basal-body rod protein FlgG DXX91_RS17430 ENOG4105DFF Rod shape-determining protein mreb DXX91_RS17440 ENOG4107MII Sugar-specific transcriptional regulator TrmB DXX91_RS17445 ENOG4105CZM Major Facilitator DXX91_RS17450 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DXX91_RS17455 ENOG41080V3 Major Facilitator superfamily DXX91_RS17460 ENOG4105D3W isochorismatase DXX91_RS17465 ENOG4105BZU Histidine kinase DXX91_RS17475 ENOG4105CNI cell division protein FtsW DXX91_RS17480 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DXX91_RS17490 ENOG4105FRN stage II sporulation protein DXX91_RS17495 ENOG4107TCE N-acetyltransferase DXX91_RS17510 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXX91_RS17515 ENOG4106BRK DXX91_RS17520 ENOG4107T94 Endo-14-beta-xylanase DXX91_RS17530 ENOG4108Z40 Transcriptional regulator DXX91_RS17535 ENOG4105CQM Urea amidohydrolase subunit alpha DXX91_RS17540 ENOG4105KI2 Urea amidohydrolase subunit beta DXX91_RS17545 ENOG4108YZ9 Urea amidohydrolase subunit gamma DXX91_RS17565 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DXX91_RS17570 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DXX91_RS17575 ENOG4108TF4 von Willebrand factor, type A DXX91_RS17590 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXX91_RS17600 ENOG4106778 Protein of unknown function (DUF1146) DXX91_RS17610 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DXX91_RS17615 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DXX91_RS17620 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DXX91_RS17625 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DXX91_RS17630 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DXX91_RS17645 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DXX91_RS17655 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DXX91_RS17660 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DXX91_RS17665 ENOG4108UIC UPF0340 protein DXX91_RS17670 ENOG4108YZG isomerase DXX91_RS17675 ENOG4107WAU Protein tyrosine phosphatase DXX91_RS17680 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DXX91_RS17685 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXX91_RS17695 ENOG4108ZXQ stage ii sporulation protein r DXX91_RS17710 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DXX91_RS17715 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DXX91_RS17720 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DXX91_RS17730 ENOG4107TT2 Auxin Efflux Carrier DXX91_RS17735 ENOG4105C6K Malic enzyme DXX91_RS17740 ENOG4107104 thymidine kinase DXX91_RS17750 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DXX91_RS17755 ENOG4105CBT Fructose-1,6-bisphosphatase DXX91_RS17760 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXX91_RS17770 ENOG4105D2N Aldolase DXX91_RS17775 ENOG410812K response regulator receiver protein DXX91_RS17785 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DXX91_RS17795 ENOG4105DF6 Fe-S oxidoreductase DXX91_RS17805 ENOG4105E5J UV damage endonuclease DXX91_RS17815 ENOG4105BZ1 (ABC) transporter DXX91_RS17820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXX91_RS17835 ENOG4105R3A Nitrate reductase DXX91_RS17840 ENOG4108IUE nitrate reductase beta subunit DXX91_RS17860 ENOG4107V6Q Cyclic nucleotide-binding domain DXX91_RS17870 ENOG4105C75 arginyL-tRNA synthetase DXX91_RS17875 ENOG410684U Domain of unknown function (DUF1934) DXX91_RS17880 ENOG4107JM4 Tetratricopeptide repeat DXX91_RS17925 ENOG4105CYW agmatinase DXX91_RS17930 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DXX91_RS17935 ENOG4105BZ4 penicillin-binding protein DXX91_RS17945 ENOG4108XFG YwhD family DXX91_RS17950 ENOG4108Z4T Peptidase M50 DXX91_RS17955 ENOG41069HH 4-oxalocrotonate tautomerase DXX91_RS17960 ENOG41067TZ transcriptional regulator, MarR family DXX91_RS17970 ENOG4105CUB amino acid DXX91_RS17980 ENOG4105DCI Phosphohydrolase DXX91_RS17990 ENOG4108VCI transcription factor, rsfa family DXX91_RS17995 ENOG4105K7K Transcriptional regulator DXX91_RS18005 ENOG4105CJ1 ABC, transporter DXX91_RS18010 ENOG4108TU7 Inherit from COG: (ABC) transporter DXX91_RS18035 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DXX91_RS18040 ENOG4105DUM transcriptional regulator, lysR family DXX91_RS18045 ENOG4105HMI Membrane DXX91_RS18050 ENOG4108IJ2 phosphate acetyltransferase DXX91_RS18055 ENOG4107JTW chlorite dismutase DXX91_RS18065 ENOG4105CHM Aminotransferase DXX91_RS18095 ENOG4105FCW Major Facilitator superfamily DXX91_RS18100 ENOG4105C2C drug resistance transporter, Bcr CflA DXX91_RS18115 ENOG4105C26 Dehydrogenase DXX91_RS18120 ENOG4105D82 Glutamate dehydrogenase DXX91_RS18130 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase DXX91_RS18135 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DXX91_RS18140 ENOG4105C1B dTDP-glucose 4-6-dehydratase DXX91_RS18145 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DXX91_RS18150 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG DXX91_RS18155 ENOG4107TY6 Acylneuraminate cytidylyltransferase DXX91_RS18165 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD DXX91_RS18170 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXX91_RS18205 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DXX91_RS18210 ENOG4108RJ9 Glycosyl transferase, family 2 DXX91_RS18230 ENOG4105DWF phosphomethylpyrimidine kinase DXX91_RS18245 ENOG4105C5Y PTS System DXX91_RS18260 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DXX91_RS18265 ENOG4105DEN Luciferase family DXX91_RS18270 ENOG4108DBC nitroreductase DXX91_RS18280 ENOG4105I4A GCN5-related N-acetyltransferase DXX91_RS18300 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXX91_RS18305 ENOG4105E2S oxidase) subunit II DXX91_RS18310 ENOG4107BMA Transglycosylase associated protein DXX91_RS18325 ENOG4105WH5 Teichoic acid glycosylation protein DXX91_RS18350 ENOG4107ZXU DSBA oxidoreductase DXX91_RS18355 ENOG4105DBE peroxidase DXX91_RS18365 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DXX91_RS18370 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DXX91_RS18375 ENOG4105CMU LysR family (Transcriptional regulator DXX91_RS18380 ENOG4105VAW lrga family DXX91_RS18385 ENOG41067MG lrgb family DXX91_RS18395 ENOG4107TXC Transcriptional regulator DXX91_RS18400 ENOG4105DR4 Methyltransferase DXX91_RS18410 ENOG4105CK1 PTS System DXX91_RS18415 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin DXX91_RS18420 ENOG4105X1N Glycosyl transferase family 8 DXX91_RS18430 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DXX91_RS18445 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DXX91_RS18450 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DXX91_RS18455 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) DXX91_RS18460 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DXX91_RS18465 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXX91_RS18470 ENOG4105F8D glycoside hydrolase family 4 DXX91_RS18475 ENOG4105VCP PTS System DXX91_RS18480 ENOG4105CK1 PTS System DXX91_RS18485 ENOG4105VZJ PTS System DXX91_RS18490 ENOG4105EMD TRANSCRIPTIONal DXX91_RS18505 ENOG4105DQ5 transport system permease protein DXX91_RS18510 ENOG4105EHG Permease protein DXX91_RS18520 ENOG41082YX Transcriptional regulator, arsr family DXX91_RS18525 ENOG4107R5R arsenical pump membrane protein DXX91_RS18530 ENOG4105VZJ PTS System DXX91_RS18535 ENOG4105VCP PTS System DXX91_RS18540 ENOG4105CK1 PTS System DXX91_RS18545 ENOG4105CS2 ec 3.2.1.21 DXX91_RS18550 ENOG4105EVU fructokinase DXX91_RS18555 ENOG4105DG6 mannose-6-phosphate isomerase DXX91_RS18565 ENOG4105CH6 catalase DXX91_RS18570 ENOG4107QHE Choloylglycine hydrolase DXX91_RS18575 ENOG4105ETS cytosine purines uracil thiamine allantoin DXX91_RS18580 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DXX91_RS18585 ENOG4108JJ8 (ABC) transporter DXX91_RS18590 ENOG4108JJ9 ABC, transporter DXX91_RS18595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DXX91_RS18600 ENOG4105C4M (Ubiquinol oxidase) subunit I DXX91_RS18605 ENOG4105D2K citrate carrier protein DXX91_RS18610 ENOG4107BJW polysaccharide deacetylase DXX91_RS18625 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DXX91_RS18635 ENOG4105CMR udp-glucose 4-epimerase DXX91_RS18640 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXX91_RS18655 ENOG4105DHI Methyltransferase DXX91_RS18675 ENOG4105CH6 catalase DXX91_RS18680 ENOG4105D4T Citrate transporter DXX91_RS18695 ENOG4105DEU major facilitator superfamily DXX91_RS18700 ENOG4105C1J atp-dependent rna helicase DXX91_RS18760 ENOG4105CNA YD repeat protein DXX91_RS18765 ENOG4108NR7 pectate lyase DXX91_RS18775 ENOG4107YZX Universal stress protein DXX91_RS18790 ENOG4105M6F mutator MutT protein DXX91_RS18795 ENOG4106Z5D Glycoside Hydrolase Family 43 DXX91_RS18805 ENOG4105C84 Histidine ammonia-lyase DXX91_RS18810 ENOG4105CGP Urocanate hydratase DXX91_RS18815 ENOG4105CI2 imidazolone-5-propionate hydrolase DXX91_RS18820 ENOG4107W25 arginase agmatinase formiminoglutamase DXX91_RS18830 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DXX91_RS18835 ENOG4105D9N nucleoside DXX91_RS18840 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DXX91_RS18845 ENOG4107RHR regulatoR DXX91_RS18850 ENOG410667J hydrolase DXX91_RS18880 ENOG4108V5C ABC transporter DXX91_RS18915 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXX91_RS18940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXX91_RS18955 ENOG4108JJA ABC, transporter DXX91_RS18965 ENOG4105WZ4 isomerase DXX91_RS18970 ENOG4105F0H myo-inositol catabolism protein DXX91_RS18975 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXX91_RS18985 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DXX91_RS18995 ENOG4105EDK PfkB domain protein DXX91_RS19005 ENOG4105C26 Dehydrogenase DXX91_RS19015 ENOG4105CPC Aldo Keto reductase DXX91_RS19020 ENOG4107QNK )-transporter DXX91_RS19025 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DXX91_RS19035 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DXX91_RS19040 ENOG4108S01 response regulator DXX91_RS19045 ENOG4108ZGX Histidine kinase DXX91_RS19050 ENOG4105ECK Fatty Acid Desaturase DXX91_RS19060 ENOG4105ST3 Transcriptional regulator DXX91_RS19065 ENOG4105C26 Dehydrogenase DXX91_RS19070 ENOG4108ITS PQQ enzyme repeat DXX91_RS19080 ENOG4105WAB arsR family transcriptional regulator DXX91_RS19085 ENOG4105F27 Major Facilitator DXX91_RS19090 ENOG41085PJ rdd domain containing protein DXX91_RS19100 ENOG4105D3R alkyl hydroperoxide reductase DXX91_RS19105 ENOG4108JU3 Alkyl hydroperoxide reductase DXX91_RS19110 ENOG4105C85 amino acid DXX91_RS19115 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DXX91_RS19120 ENOG4108XHQ (2Fe-2S)-binding domain protein DXX91_RS19140 ENOG4105XRQ Xanthine dehydrogenase accessory factor DXX91_RS19160 ENOG4107QJE Chromosome Partitioning Protein DXX91_RS19175 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DXX91_RS19195 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) DXX91_RS19200 ENOG4105CPC Aldo Keto reductase DXX91_RS19205 ENOG4105WQG acetyltransferase DXX91_RS19215 ENOG41066UZ arginase EC 3.5.3.1 DXX91_RS19220 ENOG4108IQI permease DXX91_RS19225 ENOG4105C8Y Acetylornithine aminotransferase DXX91_RS19230 ENOG4108JUB Transcriptional regulator DXX91_RS19240 ENOG4105C5H ABC transporter DXX91_RS19255 ENOG4105D06 uba thif-type nad fad binding protein DXX91_RS19260 ENOG4105BZU Histidine kinase DXX91_RS19265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS19270 ENOG4105C0H protease DXX91_RS19275 ENOG4105Q2H domain protein DXX91_RS19290 ENOG4105BZU Histidine kinase DXX91_RS19295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXX91_RS19325 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DXX91_RS19330 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DXX91_RS19335 ENOG4105CDU Replicative dna helicase DXX91_RS19360 ENOG4107QPH glycogen) synthase DXX91_RS19370 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DXX91_RS19375 ENOG4105CPK Glycosyl transferase (Group 1 DXX91_RS19395 ENOG4105BZR domain protein DXX91_RS19400 ENOG4108XMW Membrane DXX91_RS19415 ENOG4105KVH Transcriptional regulator DXX91_RS19420 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DXX91_RS19425 ENOG4108UZ3 Transporter DXX91_RS19430 ENOG4105EDQ levansucrase EC 2.4.1.10 DXX91_RS19435 ENOG4108HKT sucrose-6-phosphate hydrolase DXX91_RS19440 ENOG4107XBN GntR Family Transcriptional Regulator DXX91_RS19460 ENOG4108TVJ Nitroreductase DXX91_RS19465 ENOG4105FS7 Transcriptional regulator DXX91_RS19475 ENOG4108U05 Transcriptional regulator DXX91_RS19495 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DXX91_RS19500 ENOG4105CMU LysR family (Transcriptional regulator DXX91_RS19505 ENOG4105DTD Dehydrogenase DXX91_RS19520 ENOG4107Y9U Membrane DXX91_RS19530 ENOG4105ECP epimerase DXX91_RS19540 ENOG410847I Transcriptional regulator, BadM Rrf2 family DXX91_RS19555 ENOG4105C7Z Conserved Protein DXX91_RS19560 ENOG4107FCW Abortive infection protein DXX91_RS19570 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DXX91_RS19580 ENOG4105CGK Exodeoxyribonuclease III DXX91_RS19585 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXX91_RS19595 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DXX91_RS19600 ENOG4108UUM single-stranded DNA-binding protein DXX91_RS19605 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DXX91_RS19610 ENOG4105C3G gtp-binding protein DXX91_RS19615 ENOG4108J2R molybdopterin oxidoreductase DXX91_RS19620 ENOG4105VDK protein, conserved in bacteria DXX91_RS19635 ENOG4108ZDA Sporulation protein YyaC DXX91_RS19640 ENOG4105FA0 parb-like partition protein DXX91_RS19645 ENOG4107QJE Chromosome Partitioning Protein DXX91_RS19660 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DXX91_RS19665 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DXX91_RS19680 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DXX91_RS19690 ENOG4105CS2 ec 3.2.1.21 DXX91_RS19890 ENOG4108Z6X (sortase) family