locus-tag	class	description
HPQ66_RS00010	COG0592	DNA-directed DNA polymerase activity
HPQ66_RS00015	COG2501	S4 domain
HPQ66_RS00030	COG0187	DNA topoisomerase II activity
HPQ66_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPQ66_RS00070	COG0517	IMP dehydrogenase activity
HPQ66_RS00070	COG0516	GMP reductase activity
HPQ66_RS00075	COG1686	Belongs to the peptidase S11 family
HPQ66_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
HPQ66_RS00105	COG1428	Deoxynucleoside kinase
HPQ66_RS00110	COG1428	Deoxynucleoside kinase
HPQ66_RS00115	COG1388	LysM domain
HPQ66_RS00115	COG3858	chitin binding
HPQ66_RS00120	COG1335	isochorismatase
HPQ66_RS00125	COG0590	tRNA wobble adenosine to inosine editing
HPQ66_RS00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPQ66_RS00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPQ66_RS00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HPQ66_RS00195	COG3853	Toxic anion resistance protein (TelA)
HPQ66_RS00200	COG1982	Orn Lys Arg decarboxylase major
HPQ66_RS00210	COG3870	Protein conserved in bacteria
HPQ66_RS00215	COG1728	Protein conserved in bacteria
HPQ66_RS00220	COG0470	DNA polymerase III
HPQ66_RS00225	COG1774	PSP1 C-terminal conserved region
HPQ66_RS00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HPQ66_RS00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPQ66_RS00250	COG2002	toxin-antitoxin pair type II binding
HPQ66_RS00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPQ66_RS00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPQ66_RS00260	COG0084	hydrolase, TatD family'
HPQ66_RS00265	COG3583	domain protein
HPQ66_RS00265	COG3584	3D domain protein
HPQ66_RS00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPQ66_RS00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPQ66_RS00285	COG4466	Protein conserved in bacteria
HPQ66_RS00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPQ66_RS00305	COG0251	oxidation-reduction process
HPQ66_RS00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPQ66_RS00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPQ66_RS00345	COG2002	toxin-antitoxin pair type II binding
HPQ66_RS00350	COG2244	polysaccharide biosynthetic process
HPQ66_RS00355	COG3956	TIGRFAM MazG family protein
HPQ66_RS00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPQ66_RS00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HPQ66_RS00380	COG1098	S1 RNA binding domain
HPQ66_RS00395	COG2208	phosphoserine phosphatase activity
HPQ66_RS00400	COG2304	oxidoreductase activity
HPQ66_RS00405	COG0515	serine threonine protein kinase
HPQ66_RS00410	COG0037	tRNA processing
HPQ66_RS00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPQ66_RS00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPQ66_RS00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPQ66_RS00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPQ66_RS00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HPQ66_RS00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPQ66_RS00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPQ66_RS00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPQ66_RS00475	COG1396	sequence-specific DNA binding
HPQ66_RS00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPQ66_RS00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPQ66_RS00565	COG4463	regulation of RNA biosynthetic process
HPQ66_RS00570	COG3880	PFAM UvrB UvrC protein
HPQ66_RS00580	COG0542	response to heat
HPQ66_RS00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPQ66_RS00595	COG4956	integral membrane protein (PIN domain superfamily)
HPQ66_RS00615	COG1045	serine acetyltransferase
HPQ66_RS00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HPQ66_RS00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPQ66_RS00635	COG3688	RNA-binding protein containing a PIN domain
HPQ66_RS00640	COG1595	DNA-templated transcription, initiation
HPQ66_RS00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPQ66_RS00655	COG0250	Participates in transcription elongation, termination and antitermination
HPQ66_RS00680	COG2813	Specifically methylates the guanine in position
HPQ66_RS00695	COG1358	cellular component organization or biogenesis
HPQ66_RS00720	COG0596	Alpha beta hydrolase
HPQ66_RS00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPQ66_RS00830	COG0201	protein transport
HPQ66_RS00840	COG0024	Methionine aminopeptidase
HPQ66_RS00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPQ66_RS00875	COG1122	ATPase activity
HPQ66_RS00880	COG1122	ATPase activity
HPQ66_RS00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPQ66_RS00905	COG2226	methyltransferase
HPQ66_RS00910	COG2318	DinB family
HPQ66_RS00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS00925	COG0489	protein tyrosine kinase activity
HPQ66_RS00935	COG2194	sulfuric ester hydrolase activity
HPQ66_RS00940	COG0726	polysaccharide deacetylase
HPQ66_RS01000	COG0738	Major facilitator superfamily
HPQ66_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS01020	COG0659	secondary active sulfate transmembrane transporter activity
HPQ66_RS01025	COG0385	Bile acid
HPQ66_RS01030	COG2819	hydrolase of the alpha beta superfamily
HPQ66_RS01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPQ66_RS01050	COG2207	Transcriptional regulator
HPQ66_RS01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPQ66_RS01055	COG3876	Protein conserved in bacteria
HPQ66_RS01060	COG1472	Belongs to the glycosyl hydrolase 3 family
HPQ66_RS01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPQ66_RS01070	COG1263	PTS System
HPQ66_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPQ66_RS01085	COG1683	Conserved Protein
HPQ66_RS01115	COG1595	DNA-templated transcription, initiation
HPQ66_RS01120	COG5662	AntiSigma factor
HPQ66_RS01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPQ66_RS01130	COG4856	YbbR-like protein
HPQ66_RS01170	COG1346	cytolysis
HPQ66_RS01175	COG1380	Effector of murein hydrolase LrgA
HPQ66_RS01180	COG1846	Transcriptional regulator
HPQ66_RS01185	COG1113	amino acid transport
HPQ66_RS01190	COG1011	Hydrolase
HPQ66_RS01195	COG4585	Histidine kinase
HPQ66_RS01200	COG2197	response regulator
HPQ66_RS01205	COG1131	(ABC) transporter
HPQ66_RS01225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HPQ66_RS01245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS01245	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS01245	COG3321	synthase
HPQ66_RS01245	COG4221	oxidoreductase activity
HPQ66_RS01250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS01250	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS01250	COG3321	synthase
HPQ66_RS01250	COG0300	oxidoreductase activity
HPQ66_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS01290	COG0531	amino acid
HPQ66_RS01295	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPQ66_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
HPQ66_RS01315	COG2271	Major facilitator Superfamily
HPQ66_RS01325	COG2368	4-hydroxyphenylacetate
HPQ66_RS01335	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS01350	COG0371	Dehydrogenase
HPQ66_RS01360	COG1183	phosphatidylcholine synthase activity
HPQ66_RS01365	COG0586	Pfam SNARE associated Golgi protein
HPQ66_RS01370	COG0688	phosphatidylethanolamine metabolic process
HPQ66_RS01385	COG1301	dicarboxylic acid transport
HPQ66_RS01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS01395	COG0833	amino acid
HPQ66_RS01400	COG2040	homocysteine
HPQ66_RS01405	COG1115	amino acid carrier protein
HPQ66_RS01410	COG2066	Belongs to the glutaminase family
HPQ66_RS01415	COG4191	Histidine kinase
HPQ66_RS01420	COG0784	Response regulator, receiver
HPQ66_RS01425	COG3173	Aminoglycoside phosphotransferase
HPQ66_RS01435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPQ66_RS01440	COG0778	Nitroreductase
HPQ66_RS01445	COG0346	lactoylglutathione lyase activity
HPQ66_RS01450	COG2259	Doxx family
HPQ66_RS01455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS01465	COG3773	Cell wall hydrolase
HPQ66_RS01470	COG3540	Alkaline phosphatase
HPQ66_RS01475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPQ66_RS01480	COG0805	protein transport
HPQ66_RS01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPQ66_RS01495	COG0477	Major facilitator Superfamily
HPQ66_RS01500	COG1309	transcriptional regulator
HPQ66_RS01505	COG0252	asparaginase activity
HPQ66_RS01510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HPQ66_RS01515	COG3012	SEC-C Motif Domain Protein
HPQ66_RS01515	COG1405	negative regulation of cell septum assembly
HPQ66_RS01520	COG0667	Aldo Keto reductase
HPQ66_RS01530	COG1595	DNA-templated transcription, initiation
HPQ66_RS01535	COG1595	DNA-templated transcription, initiation
HPQ66_RS01540	COG1876	peptidase activity
HPQ66_RS01545	COG0457	Tetratricopeptide repeat
HPQ66_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS01555	COG0366	Alpha amylase catalytic
HPQ66_RS01560	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPQ66_RS01565	COG1121	(ABC) transporter
HPQ66_RS01570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPQ66_RS01575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS01580	COG2310	stress, protein
HPQ66_RS01585	COG2310	stress, protein
HPQ66_RS01590	COG2310	stress, protein
HPQ66_RS01595	COG0861	Integral membrane protein TerC family
HPQ66_RS01605	COG3853	Toxic anion resistance protein (TelA)
HPQ66_RS01610	COG0477	Major facilitator Superfamily
HPQ66_RS01615	COG0517	IMP dehydrogenase activity
HPQ66_RS01615	COG4175	Glycine betaine
HPQ66_RS01620	COG4176	ABC-type proline glycine betaine transport system permease component
HPQ66_RS01625	COG2113	Glycine betaine
HPQ66_RS01630	COG1473	amidohydrolase
HPQ66_RS01635	COG1288	antiporter activity
HPQ66_RS01645	COG0366	Alpha amylase catalytic
HPQ66_RS01655	COG2814	Major facilitator Superfamily
HPQ66_RS01660	COG1846	Transcriptional regulator
HPQ66_RS01665	COG1280	lysine exporter protein (LysE YggA)
HPQ66_RS01670	COG3403	YqcI/YcgG family
HPQ66_RS01675	COG1113	amino acid transport
HPQ66_RS01680	COG3665	Urea carboxylase-associated protein
HPQ66_RS01695	COG1660	Displays ATPase and GTPase activities
HPQ66_RS01705	COG2271	Major facilitator Superfamily
HPQ66_RS01710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPQ66_RS01715	COG3458	cephalosporin-C deacetylase activity
HPQ66_RS01720	COG3541	Predicted nucleotidyltransferase
HPQ66_RS01725	COG0506	proline dehydrogenase activity
HPQ66_RS01730	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS01735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPQ66_RS01740	COG2508	Transcriptional regulator
HPQ66_RS01750	COG1587	Uroporphyrinogen-III synthase
HPQ66_RS01750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPQ66_RS01755	COG2146	nitrite reductase [NAD(P)H] activity
HPQ66_RS01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPQ66_RS01765	COG0523	cobalamin synthesis protein
HPQ66_RS01770	COG1063	alcohol dehydrogenase
HPQ66_RS01775	COG1714	RDD family
HPQ66_RS01800	COG3209	COG3209 Rhs family protein
HPQ66_RS01805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPQ66_RS01810	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPQ66_RS01815	COG1733	regulation of RNA biosynthetic process
HPQ66_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS01825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS01830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS01835	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HPQ66_RS01850	COG2364	Membrane
HPQ66_RS01855	COG1126	abc transporter atp-binding protein
HPQ66_RS01860	COG0765	amino acid transport
HPQ66_RS01865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS01870	COG0583	DNA-binding transcription factor activity
HPQ66_RS01875	COG0163	prenyltransferase activity
HPQ66_RS01880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPQ66_RS01895	COG3104	oligopeptide transport
HPQ66_RS01900	COG5434	Belongs to the glycosyl hydrolase 28 family
HPQ66_RS01910	COG0697	spore germination
HPQ66_RS01920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPQ66_RS01925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS01930	COG0456	acetyltransferase
HPQ66_RS01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS01940	COG0765	amino acid transport
HPQ66_RS01945	COG1126	abc transporter atp-binding protein
HPQ66_RS01950	COG1473	amidohydrolase
HPQ66_RS01955	COG2079	MmgE PrpD family protein
HPQ66_RS01960	COG1136	(ABC) transporter
HPQ66_RS01965	COG0577	efflux transmembrane transporter activity
HPQ66_RS01970	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS01975	COG3850	Histidine kinase
HPQ66_RS01975	COG5002	protein histidine kinase activity
HPQ66_RS01980	COG0457	Tetratricopeptide repeat
HPQ66_RS01995	COG0527	aspartate kinase activity
HPQ66_RS02000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS02005	COG4605	iron ion homeostasis
HPQ66_RS02010	COG4604	ABC transporter, ATP-binding protein
HPQ66_RS02015	COG4607	ABC-type enterochelin transport system periplasmic component
HPQ66_RS02020	COG2814	Major facilitator Superfamily
HPQ66_RS02025	COG1309	transcriptional regulator
HPQ66_RS02030	COG0778	Nitroreductase
HPQ66_RS02035	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPQ66_RS02040	COG0640	Transcriptional regulator
HPQ66_RS02045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPQ66_RS02050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS02055	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS02060	COG4975	Glucose uptake
HPQ66_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS02070	COG4549	nuclear export factor GLE1
HPQ66_RS02075	COG1276	copper resistance
HPQ66_RS02075	COG2372	response to copper ion
HPQ66_RS02080	COG1349	DNA-binding transcription factor activity
HPQ66_RS02090	COG2213	PTS system mannitol-specific
HPQ66_RS02095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS02105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPQ66_RS02115	COG0561	phosphatase activity
HPQ66_RS02125	COG1914	H( )-stimulated, divalent metal cation uptake system
HPQ66_RS02135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPQ66_RS02140	COG1984	allophanate hydrolase subunit 2
HPQ66_RS02145	COG1414	Transcriptional regulator
HPQ66_RS02150	COG2755	lipolytic protein G-D-S-L family
HPQ66_RS02160	COG2329	Antibiotic biosynthesis monooxygenase
HPQ66_RS02165	COG0768	penicillin binding
HPQ66_RS02170	COG4989	oxidoreductase activity
HPQ66_RS02175	COG3711	transcriptional antiterminator
HPQ66_RS02180	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS02190	COG1917	Cupin 2, conserved barrel domain protein
HPQ66_RS02195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPQ66_RS02200	COG3871	stress protein (general stress protein 26)
HPQ66_RS02210	COG2814	Major facilitator Superfamily
HPQ66_RS02215	COG1522	sequence-specific DNA binding
HPQ66_RS02220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPQ66_RS02220	COG0551	DNA topoisomerase type I activity
HPQ66_RS02225	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPQ66_RS02230	COG3706	GGDEF domain
HPQ66_RS02235	COG5298	Protein conserved in bacteria
HPQ66_RS02240	COG1215	transferase activity, transferring glycosyl groups
HPQ66_RS02250	COG0531	amino acid
HPQ66_RS02255	COG0494	nUDIX hydrolase
HPQ66_RS02260	COG0028	Belongs to the TPP enzyme family
HPQ66_RS02320	COG1914	H( )-stimulated, divalent metal cation uptake system
HPQ66_RS02330	COG4876	unkown
HPQ66_RS02340	COG2076	Multidrug Resistance protein
HPQ66_RS02345	COG2217	Heavy metal translocating P-type atpase
HPQ66_RS02350	COG3729	General stress protein
HPQ66_RS02355	COG0662	Cupin 2, conserved barrel domain protein
HPQ66_RS02360	COG2329	Antibiotic biosynthesis monooxygenase
HPQ66_RS02365	COG3546	catalase activity
HPQ66_RS02370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPQ66_RS02375	COG3290	protein histidine kinase activity
HPQ66_RS02380	COG4565	transcriptional regulatory protein
HPQ66_RS02385	COG1301	dicarboxylic acid transport
HPQ66_RS02390	COG0628	permease
HPQ66_RS02395	COG1131	(ABC) transporter
HPQ66_RS02400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPQ66_RS02410	COG1960	acyl-CoA dehydrogenase activity
HPQ66_RS02425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPQ66_RS02430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS02440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPQ66_RS02445	COG0513	Belongs to the DEAD box helicase family
HPQ66_RS02450	COG3402	PFAM membrane-flanked domain
HPQ66_RS02455	COG3428	Bacterial PH domain
HPQ66_RS02460	COG0705	Rhomboid family
HPQ66_RS02470	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPQ66_RS02475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPQ66_RS02480	COG0864	Transcriptional regulator
HPQ66_RS02485	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPQ66_RS02490	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS02495	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS02500	COG2172	sigma factor antagonist activity
HPQ66_RS02505	COG2208	phosphoserine phosphatase activity
HPQ66_RS02510	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS02520	COG1191	sigma factor activity
HPQ66_RS02525	COG2208	phosphoserine phosphatase activity
HPQ66_RS02530	COG2183	response to ionizing radiation
HPQ66_RS02610	COG0457	Tetratricopeptide repeat
HPQ66_RS02630	COG0477	Major facilitator Superfamily
HPQ66_RS02640	COG1764	response to oxidative stress
HPQ66_RS02645	COG1846	Transcriptional regulator
HPQ66_RS02655	COG1959	2 iron, 2 sulfur cluster binding
HPQ66_RS02660	COG2910	NAD(P)H-binding
HPQ66_RS02665	COG1278	Cold shock
HPQ66_RS02670	COG1329	Transcriptional regulator
HPQ66_RS02675	COG1794	racemase activity, acting on amino acids and derivatives
HPQ66_RS02690	COG1846	Transcriptional regulator
HPQ66_RS02690	COG0456	acetyltransferase
HPQ66_RS02700	COG3621	Patatin-like phospholipase
HPQ66_RS02715	COG0277	FAD linked oxidase domain protein
HPQ66_RS02735	COG0662	Cupin 2, conserved barrel domain protein
HPQ66_RS02740	COG2318	DinB family
HPQ66_RS02745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPQ66_RS02770	COG0351	phosphomethylpyrimidine kinase
HPQ66_RS02785	COG1064	alcohol dehydrogenase
HPQ66_RS02790	COG0789	Transcriptional regulator
HPQ66_RS02800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPQ66_RS02815	COG2814	Major facilitator Superfamily
HPQ66_RS02820	COG1309	transcriptional regulator
HPQ66_RS02825	COG5577	PFAM Coat F domain
HPQ66_RS02835	COG1063	alcohol dehydrogenase
HPQ66_RS02840	COG5577	PFAM Coat F domain
HPQ66_RS02850	COG4585	Histidine kinase
HPQ66_RS02855	COG2197	response regulator
HPQ66_RS02860	COG2409	Drug exporters of the RND superfamily
HPQ66_RS02865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPQ66_RS02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPQ66_RS02880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS02890	COG2814	Major facilitator Superfamily
HPQ66_RS02895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPQ66_RS02905	COG0730	response to heat
HPQ66_RS02910	COG0456	acetyltransferase
HPQ66_RS02915	COG0789	Transcriptional regulator
HPQ66_RS02915	COG4978	Transcriptional regulator
HPQ66_RS02920	COG0697	spore germination
HPQ66_RS02925	COG1051	belongs to the nudix hydrolase family
HPQ66_RS02930	COG0596	Alpha beta hydrolase
HPQ66_RS02935	COG0473	3-isopropylmalate dehydrogenase activity
HPQ66_RS02940	COG1802	Transcriptional regulator
HPQ66_RS02945	COG1819	glycosyl
HPQ66_RS02960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPQ66_RS02970	COG1388	LysM domain
HPQ66_RS02975	COG2814	Major facilitator Superfamily
HPQ66_RS02980	COG2188	Transcriptional regulator
HPQ66_RS02985	COG2186	Transcriptional regulator
HPQ66_RS02990	COG2807	transmembrane transport
HPQ66_RS02995	COG2076	Multidrug Resistance protein
HPQ66_RS03000	COG2076	Multidrug Resistance protein
HPQ66_RS03005	COG1309	transcriptional regulator
HPQ66_RS03010	COG0531	amino acid
HPQ66_RS03020	COG3832	glyoxalase III activity
HPQ66_RS03025	COG0604	alcohol dehydrogenase
HPQ66_RS03030	COG2814	Major facilitator Superfamily
HPQ66_RS03070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPQ66_RS03075	COG0802	atpase or kinase
HPQ66_RS03080	COG1214	PFAM Peptidase M22, glycoprotease
HPQ66_RS03085	COG0456	acetyltransferase
HPQ66_RS03090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPQ66_RS03095	COG0488	(ABC) transporter
HPQ66_RS03110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPQ66_RS03115	COG0805	protein transport
HPQ66_RS03125	COG1266	CAAX protease self-immunity
HPQ66_RS03165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPQ66_RS03170	COG0457	Tetratricopeptide repeat
HPQ66_RS03175	COG1063	alcohol dehydrogenase
HPQ66_RS03180	COG2211	Major facilitator Superfamily
HPQ66_RS03185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPQ66_RS03195	COG1842	Phage shock protein A
HPQ66_RS03200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPQ66_RS03205	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPQ66_RS03210	COG4260	virion core protein, lumpy skin disease virus
HPQ66_RS03215	COG2755	lipolytic protein G-D-S-L family
HPQ66_RS03215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPQ66_RS03225	COG1595	DNA-templated transcription, initiation
HPQ66_RS03230	COG1063	alcohol dehydrogenase
HPQ66_RS03235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPQ66_RS03240	COG0823	Involved in the tonB-independent uptake of proteins
HPQ66_RS03255	COG2132	Multicopper oxidase
HPQ66_RS03260	COG1113	amino acid transport
HPQ66_RS03265	COG0714	Associated with various cellular activities
HPQ66_RS03270	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HPQ66_RS03275	COG1305	Transglutaminase-like
HPQ66_RS03295	COG2252	PERMEase
HPQ66_RS03300	COG3064	Membrane
HPQ66_RS03320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPQ66_RS03325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPQ66_RS03330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPQ66_RS03335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPQ66_RS03340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPQ66_RS03355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPQ66_RS03365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPQ66_RS03370	COG0138	bifunctional purine biosynthesis protein purh
HPQ66_RS03375	COG0151	Belongs to the GarS family
HPQ66_RS03390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HPQ66_RS03395	COG1470	cell adhesion involved in biofilm formation
HPQ66_RS03400	COG4496	protein, YerC YecD
HPQ66_RS03405	COG0069	glutamate synthase activity
HPQ66_RS03415	COG0210	DNA helicase
HPQ66_RS03425	COG4851	CamS sex pheromone cAM373 precursor
HPQ66_RS03430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPQ66_RS03435	COG1285	pathogenesis
HPQ66_RS03440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPQ66_RS03460	COG1309	transcriptional regulator
HPQ66_RS03465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPQ66_RS03470	COG1597	lipid kinase activity
HPQ66_RS03475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPQ66_RS03525	COG5444	nuclease activity
HPQ66_RS03555	COG3546	catalase activity
HPQ66_RS03560	COG0454	-acetyltransferase
HPQ66_RS03570	COG2323	membrane
HPQ66_RS03575	COG2329	Antibiotic biosynthesis monooxygenase
HPQ66_RS03580	COG0346	lactoylglutathione lyase activity
HPQ66_RS03585	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS03590	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPQ66_RS03595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPQ66_RS03600	COG4208	sulfate ABC transporter
HPQ66_RS03610	COG5583	Uncharacterized small protein (DUF2292)
HPQ66_RS03615	COG0196	riboflavin kinase activity
HPQ66_RS03620	COG0670	Belongs to the BI1 family
HPQ66_RS03625	COG1846	Transcriptional regulator
HPQ66_RS03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPQ66_RS03645	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPQ66_RS03645	COG2124	cytochrome p450
HPQ66_RS03650	COG1368	sulfuric ester hydrolase activity
HPQ66_RS03655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPQ66_RS03660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS03665	COG1442	glycosyl transferase family 8
HPQ66_RS03670	COG1216	Glycosyl transferase, family 2
HPQ66_RS03675	COG1442	glycosyl transferase family 8
HPQ66_RS03680	COG2223	nitrite transmembrane transporter activity
HPQ66_RS03685	COG0531	amino acid
HPQ66_RS03690	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS03695	COG0840	transmembrane signaling receptor activity
HPQ66_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS03705	COG0463	Glycosyl transferase, family 2
HPQ66_RS03705	COG0457	Tetratricopeptide repeat
HPQ66_RS03710	COG0488	(ABC) transporter
HPQ66_RS03715	COG0789	Transcriptional regulator
HPQ66_RS03720	COG2814	Major facilitator Superfamily
HPQ66_RS03725	COG0488	(ABC) transporter
HPQ66_RS03730	COG0513	Belongs to the DEAD box helicase family
HPQ66_RS03735	COG0456	acetyltransferase
HPQ66_RS03740	COG2130	NADP-dependent
HPQ66_RS03755	COG3866	Pectate lyase
HPQ66_RS03760	COG0471	metal ion transport
HPQ66_RS03775	COG3290	protein histidine kinase activity
HPQ66_RS03780	COG4565	transcriptional regulatory protein
HPQ66_RS03785	COG3181	Tripartite tricarboxylate transporter family receptor
HPQ66_RS03790	COG2851	Citrate transporter
HPQ66_RS03795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS03800	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HPQ66_RS03810	COG2258	MOSC domain
HPQ66_RS03830	COG0024	Methionine aminopeptidase
HPQ66_RS03835	COG1263	PTS System
HPQ66_RS03835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS03845	COG1368	sulfuric ester hydrolase activity
HPQ66_RS03855	COG0071	Belongs to the small heat shock protein (HSP20) family
HPQ66_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS03870	COG1263	PTS System
HPQ66_RS03875	COG0366	Alpha amylase catalytic
HPQ66_RS03880	COG2188	Transcriptional regulator
HPQ66_RS03885	COG0778	Nitroreductase
HPQ66_RS03900	COG0737	Belongs to the 5'-nucleotidase family
HPQ66_RS03905	COG0693	protein deglycase activity
HPQ66_RS03910	COG1609	Transcriptional regulator
HPQ66_RS03925	COG2814	Major facilitator Superfamily
HPQ66_RS03935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPQ66_RS03940	COG4980	gas vesicle protein
HPQ66_RS03945	COG1295	ribonuclease BN
HPQ66_RS03950	COG0477	Major facilitator Superfamily
HPQ66_RS03955	COG0387	Pfam Sodium calcium exchanger
HPQ66_RS03965	COG0668	transmembrane transport
HPQ66_RS03970	COG0535	radical SAM domain protein
HPQ66_RS03980	COG0726	polysaccharide deacetylase
HPQ66_RS03985	COG2084	Dehydrogenase
HPQ66_RS03995	COG0598	Magnesium transport protein CorA
HPQ66_RS04000	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPQ66_RS04005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPQ66_RS04015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPQ66_RS04020	COG4637	Psort location Cytoplasmic, score
HPQ66_RS04025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPQ66_RS04030	COG0022	dehydrogenase e1 component
HPQ66_RS04035	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPQ66_RS04040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPQ66_RS04045	COG3284	Transcriptional regulator
HPQ66_RS04055	COG1486	melibiose metabolic process
HPQ66_RS04060	COG1737	Transcriptional regulator
HPQ66_RS04065	COG1263	PTS System
HPQ66_RS04065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS04070	COG5434	Belongs to the glycosyl hydrolase 28 family
HPQ66_RS04075	COG1132	(ABC) transporter
HPQ66_RS04080	COG1132	(ABC) transporter
HPQ66_RS04085	COG2259	Doxx family
HPQ66_RS04090	COG2514	catechol 2,3-dioxygenase activity
HPQ66_RS04100	COG1695	Transcriptional regulator
HPQ66_RS04105	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPQ66_RS04110	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HPQ66_RS04115	COG0574	Belongs to the PEP-utilizing enzyme family
HPQ66_RS04115	COG3848	Pyruvate phosphate dikinase
HPQ66_RS04120	COG2732	(Barnase) inhibitor
HPQ66_RS04125	COG2318	DinB family
HPQ66_RS04130	COG2814	Major facilitator Superfamily
HPQ66_RS04135	COG1846	Transcriptional regulator
HPQ66_RS04140	COG0392	lysyltransferase activity
HPQ66_RS04140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HPQ66_RS04145	COG0384	phenazine biosynthesis protein PhzF
HPQ66_RS04150	COG0778	Nitroreductase
HPQ66_RS04165	COG1090	epimerase
HPQ66_RS04180	COG2814	Major facilitator Superfamily
HPQ66_RS04190	COG3591	Belongs to the peptidase S1B family
HPQ66_RS04205	COG3103	Sh3 type 3 domain protein
HPQ66_RS04210	COG5658	integral membrane protein
HPQ66_RS04215	COG0596	Alpha beta hydrolase
HPQ66_RS04220	COG0463	Glycosyl transferase, family 2
HPQ66_RS04225	COG4485	Bacterial membrane protein, YfhO
HPQ66_RS04230	COG1988	membrane-bound metal-dependent
HPQ66_RS04235	COG1194	a g-specific adenine glycosylase
HPQ66_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS04265	COG1132	(ABC) transporter
HPQ66_RS04270	COG4129	membrane
HPQ66_RS04280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPQ66_RS04285	COG0735	belongs to the Fur family
HPQ66_RS04400	COG3340	Belongs to the peptidase S51 family
HPQ66_RS04410	COG0277	FAD linked oxidase domain protein
HPQ66_RS04420	COG0747	negative chemotaxis
HPQ66_RS04425	COG0601	transmembrane transport
HPQ66_RS04430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPQ66_RS04435	COG0444	Belongs to the ABC transporter superfamily
HPQ66_RS04440	COG4608	Belongs to the ABC transporter superfamily
HPQ66_RS04445	COG0753	catalase activity
HPQ66_RS04455	COG1116	anion transmembrane transporter activity
HPQ66_RS04460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPQ66_RS04465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPQ66_RS04485	COG1476	TRANSCRIPTIONal
HPQ66_RS04495	COG3382	B3 4 domain protein
HPQ66_RS04500	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPQ66_RS04510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPQ66_RS04515	COG0789	Transcriptional regulator
HPQ66_RS04520	COG1664	Polymer-forming cytoskeletal
HPQ66_RS04525	COG1664	Polymer-forming cytoskeletal
HPQ66_RS04530	COG2766	serine protein kinase
HPQ66_RS04540	COG1846	Transcriptional regulator
HPQ66_RS04545	COG1566	PFAM secretion protein HlyD family protein
HPQ66_RS04550	COG2814	Major facilitator Superfamily
HPQ66_RS04555	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPQ66_RS04570	COG1725	Transcriptional regulator
HPQ66_RS04575	COG1131	(ABC) transporter
HPQ66_RS04580	COG1131	(ABC) transporter
HPQ66_RS04585	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPQ66_RS04590	COG1278	Cold shock
HPQ66_RS04595	COG1464	Belongs to the NlpA lipoprotein family
HPQ66_RS04600	COG3706	GGDEF domain
HPQ66_RS04605	COG1823	symporter activity
HPQ66_RS04625	COG5577	PFAM Coat F domain
HPQ66_RS04630	COG4085	toxin activity
HPQ66_RS04630	COG0737	Belongs to the 5'-nucleotidase family
HPQ66_RS04630	COG1525	nuclease
HPQ66_RS04635	COG3764	Sortase (surface protein transpeptidase)
HPQ66_RS04640	COG0564	pseudouridine synthase activity
HPQ66_RS04650	COG0517	IMP dehydrogenase activity
HPQ66_RS04655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPQ66_RS04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPQ66_RS04660	COG3153	acetyltransferase
HPQ66_RS04665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPQ66_RS04670	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPQ66_RS04675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPQ66_RS04685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPQ66_RS04690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPQ66_RS04695	COG4585	Histidine kinase
HPQ66_RS04695	COG2203	Gaf domain
HPQ66_RS04700	COG2197	response regulator
HPQ66_RS04705	COG0431	NADPH-dependent FMN reductase
HPQ66_RS04720	COG0791	NLP P60 protein
HPQ66_RS04720	COG1388	LysM domain
HPQ66_RS04725	COG1959	2 iron, 2 sulfur cluster binding
HPQ66_RS04730	COG0668	transmembrane transport
HPQ66_RS04735	COG2719	SpoVR family
HPQ66_RS04740	COG1785	Belongs to the alkaline phosphatase family
HPQ66_RS04745	COG1388	LysM domain
HPQ66_RS04745	COG0791	NLP P60 protein
HPQ66_RS04750	COG0583	DNA-binding transcription factor activity
HPQ66_RS04755	COG0372	Belongs to the citrate synthase family
HPQ66_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS04765	COG0531	amino acid
HPQ66_RS04770	COG0733	neurotransmitter:sodium symporter activity
HPQ66_RS04785	COG1595	DNA-templated transcription, initiation
HPQ66_RS04790	COG0204	Acyl-transferase
HPQ66_RS04795	COG1253	flavin adenine dinucleotide binding
HPQ66_RS04800	COG0789	Transcriptional regulator
HPQ66_RS04805	COG0436	Aminotransferase
HPQ66_RS04810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPQ66_RS04815	COG1253	flavin adenine dinucleotide binding
HPQ66_RS04820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPQ66_RS04825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPQ66_RS04830	COG0584	glycerophosphoryl diester phosphodiesterase
HPQ66_RS04840	COG0668	transmembrane transport
HPQ66_RS04845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPQ66_RS04850	COG0726	polysaccharide deacetylase
HPQ66_RS04855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS04860	COG3226	Transcriptional regulator
HPQ66_RS04870	COG0589	response to stress
HPQ66_RS04875	COG1132	(ABC) transporter
HPQ66_RS04880	COG1132	(ABC) transporter
HPQ66_RS04885	COG0702	epimerase
HPQ66_RS04900	COG0189	ligase activity
HPQ66_RS04905	COG0189	ligase activity
HPQ66_RS04920	COG4335	DNA alkylation repair
HPQ66_RS04925	COG0561	phosphatase activity
HPQ66_RS04930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPQ66_RS04940	COG0475	glutathione-regulated potassium exporter activity
HPQ66_RS04945	COG0490	domain, Protein
HPQ66_RS04955	COG1024	Enoyl-CoA hydratase
HPQ66_RS04965	COG4152	abc transporter atp-binding protein
HPQ66_RS04970	COG1668	transmembrane transport
HPQ66_RS04975	COG0420	3'-5' exonuclease activity
HPQ66_RS04980	COG4717	serine-type aminopeptidase activity
HPQ66_RS04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPQ66_RS05030	COG4980	gas vesicle protein
HPQ66_RS05045	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPQ66_RS05050	COG0537	adenosine 5'-monophosphoramidase activity
HPQ66_RS05055	COG1131	(ABC) transporter
HPQ66_RS05060	COG4473	ABC transporter
HPQ66_RS05070	COG1473	amidohydrolase
HPQ66_RS05075	COG3069	C4-dicarboxylate transmembrane transporter activity
HPQ66_RS05080	COG2329	Antibiotic biosynthesis monooxygenase
HPQ66_RS05085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPQ66_RS05105	COG1309	transcriptional regulator
HPQ66_RS05110	COG1511	domain protein
HPQ66_RS05115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPQ66_RS05125	COG1363	Peptidase, m42
HPQ66_RS05130	COG1301	dicarboxylic acid transport
HPQ66_RS05140	COG1234	tRNA 3'-trailer cleavage
HPQ66_RS05145	COG0095	Lipoate-protein ligase
HPQ66_RS05150	COG0702	epimerase
HPQ66_RS05155	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS05165	COG0501	Belongs to the peptidase M48B family
HPQ66_RS05170	COG1404	Belongs to the peptidase S8 family
HPQ66_RS05175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HPQ66_RS05180	COG0406	alpha-ribazole phosphatase activity
HPQ66_RS05185	COG0183	Belongs to the thiolase family
HPQ66_RS05190	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS05195	COG1268	BioY protein
HPQ66_RS05200	COG0840	transmembrane signaling receptor activity
HPQ66_RS05205	COG0723	plastoquinol--plastocyanin reductase activity
HPQ66_RS05205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPQ66_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS05220	COG4903	ComK protein
HPQ66_RS05230	COG5646	InterPro IPR014922
HPQ66_RS05250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPQ66_RS05265	COG0398	Pfam SNARE associated Golgi protein
HPQ66_RS05270	COG0681	Belongs to the peptidase S26 family
HPQ66_RS05275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPQ66_RS05280	COG1846	Transcriptional regulator
HPQ66_RS05285	COG3180	Ammonia monooxygenase
HPQ66_RS05290	COG2814	Major facilitator Superfamily
HPQ66_RS05300	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HPQ66_RS05320	COG0420	3'-5' exonuclease activity
HPQ66_RS05325	COG0419	ATPase involved in DNA repair
HPQ66_RS05330	COG1403	HNH endonuclease
HPQ66_RS05370	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPQ66_RS05385	COG0367	asparagine synthase
HPQ66_RS05390	COG1562	ergosterol biosynthetic process
HPQ66_RS05395	COG0534	Mate efflux family protein
HPQ66_RS05400	COG2207	Transcriptional regulator
HPQ66_RS05400	COG1917	Cupin 2, conserved barrel domain protein
HPQ66_RS05405	COG2318	DinB family
HPQ66_RS05410	COG1357	PFAM Pentapeptide repeats (8 copies)
HPQ66_RS05415	COG2153	protein acetylation
HPQ66_RS05420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPQ66_RS05420	COG0646	methionine synthase
HPQ66_RS05430	COG2996	Protein conserved in bacteria
HPQ66_RS05440	COG0840	transmembrane signaling receptor activity
HPQ66_RS05445	COG2124	cytochrome p450
HPQ66_RS05455	COG1307	EDD domain protein, DegV family
HPQ66_RS05460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS05480	COG0561	phosphatase activity
HPQ66_RS05485	COG1073	alpha beta
HPQ66_RS05490	COG2151	metal-sulfur cluster biosynthetic enzyme
HPQ66_RS05500	COG0277	FAD linked oxidase domain protein
HPQ66_RS05505	COG2271	Major facilitator Superfamily
HPQ66_RS05515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPQ66_RS05525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPQ66_RS05530	COG0505	Belongs to the CarA family
HPQ66_RS05535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPQ66_RS05540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPQ66_RS05555	COG2267	carboxylic ester hydrolase activity
HPQ66_RS05565	COG1744	ABC transporter substrate-binding protein PnrA-like
HPQ66_RS05580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPQ66_RS05585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPQ66_RS05590	COG5504	Zn-dependent protease
HPQ66_RS05595	COG0444	Belongs to the ABC transporter superfamily
HPQ66_RS05600	COG4608	Belongs to the ABC transporter superfamily
HPQ66_RS05610	COG0601	transmembrane transport
HPQ66_RS05615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPQ66_RS05625	COG0180	Tryptophanyl-tRNA synthetase
HPQ66_RS05630	COG4166	transmembrane transport
HPQ66_RS05635	COG0601	transmembrane transport
HPQ66_RS05640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPQ66_RS05645	COG0444	Belongs to the ABC transporter superfamily
HPQ66_RS05650	COG4608	Belongs to the ABC transporter superfamily
HPQ66_RS05660	COG0456	acetyltransferase
HPQ66_RS05665	COG1393	Belongs to the ArsC family
HPQ66_RS05670	COG0861	Integral membrane protein TerC family
HPQ66_RS05675	COG4862	establishment of competence for transformation
HPQ66_RS05680	COG4469	Competence protein
HPQ66_RS05685	COG1164	Oligoendopeptidase f
HPQ66_RS05700	COG2346	COG2346, Truncated hemoglobins
HPQ66_RS05705	COG0741	lytic transglycosylase activity
HPQ66_RS05710	COG4116	CYTH
HPQ66_RS05720	COG2357	RelA SpoT domain protein
HPQ66_RS05725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPQ66_RS05730	COG0564	pseudouridine synthase activity
HPQ66_RS05740	COG0569	domain protein
HPQ66_RS05740	COG0475	glutathione-regulated potassium exporter activity
HPQ66_RS05745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPQ66_RS05750	COG0352	thiamine-phosphate diphosphorylase activity
HPQ66_RS05755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPQ66_RS05760	COG2104	thiamine diphosphate biosynthetic process
HPQ66_RS05770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPQ66_RS05775	COG0351	phosphomethylpyrimidine kinase
HPQ66_RS05780	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPQ66_RS05835	COG0210	DNA helicase
HPQ66_RS05855	COG1131	(ABC) transporter
HPQ66_RS05865	COG2153	protein acetylation
HPQ66_RS05875	COG2382	esterase
HPQ66_RS05880	COG0626	cystathionine gamma-synthase activity
HPQ66_RS05885	COG0626	cystathionine gamma-synthase activity
HPQ66_RS05900	COG5444	nuclease activity
HPQ66_RS05930	COG2367	Beta-lactamase
HPQ66_RS05935	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPQ66_RS05945	COG1846	Transcriptional regulator
HPQ66_RS05955	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPQ66_RS05960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPQ66_RS05965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPQ66_RS05970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS05970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS05975	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPQ66_RS05985	COG1349	DNA-binding transcription factor activity
HPQ66_RS06005	COG1285	pathogenesis
HPQ66_RS06020	COG2205	protein histidine kinase activity
HPQ66_RS06030	COG3383	formate dehydrogenase (NAD+) activity
HPQ66_RS06035	COG2427	Protein of unknown function (DUF1641)
HPQ66_RS06040	COG2124	cytochrome p450
HPQ66_RS06045	COG1819	glycosyl
HPQ66_RS06055	COG1587	Uroporphyrinogen-III synthase
HPQ66_RS06060	COG0390	transport system, permease component
HPQ66_RS06065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPQ66_RS06070	COG0697	spore germination
HPQ66_RS06075	COG4297	protein containing double-stranded beta helix domain
HPQ66_RS06085	COG1252	NADH dehydrogenase
HPQ66_RS06095	COG2211	Major facilitator Superfamily
HPQ66_RS06100	COG1609	Transcriptional regulator
HPQ66_RS06105	COG2721	sulfolactate sulfo-lyase activity
HPQ66_RS06110	COG0730	response to heat
HPQ66_RS06115	COG2318	DinB family
HPQ66_RS06120	COG0457	Tetratricopeptide repeat
HPQ66_RS06130	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS06130	COG1388	LysM domain
HPQ66_RS06130	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS06140	COG4195	phage-related replication protein
HPQ66_RS06150	COG2856	Zn peptidase
HPQ66_RS06155	COG1396	sequence-specific DNA binding
HPQ66_RS06165	COG1522	sequence-specific DNA binding
HPQ66_RS06170	COG1484	DNA-dependent DNA replication
HPQ66_RS06190	COG1595	DNA-templated transcription, initiation
HPQ66_RS06195	COG3728	DNA packaging
HPQ66_RS06195	COG5484	DNA packaging
HPQ66_RS06200	COG1783	phage Terminase large subunit
HPQ66_RS06205	COG5518	Phage portal protein
HPQ66_RS06210	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPQ66_RS06215	COG4653	Phage capsid family
HPQ66_RS06265	COG3953	SLT domain
HPQ66_RS06265	COG5412	phage tail tape measure protein
HPQ66_RS06265	COG3953	SLT domain
HPQ66_RS06265	COG3953	SLT domain
HPQ66_RS06265	COG5412	phage tail tape measure protein
HPQ66_RS06265	COG5412	phage tail tape measure protein
HPQ66_RS06270	COG1652	LysM domain
HPQ66_RS06275	COG4193	domain, Protein
HPQ66_RS06285	COG3628	GPW Gp25 family protein
HPQ66_RS06290	COG3299	homolog of phage Mu protein gp47
HPQ66_RS06295	COG3778	Protein conserved in bacteria
HPQ66_RS06335	COG5632	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS06335	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS06350	COG0306	phosphate transporter
HPQ66_RS06355	COG1392	Phosphate transport regulator
HPQ66_RS06360	COG0531	amino acid
HPQ66_RS06365	COG0346	lactoylglutathione lyase activity
HPQ66_RS06370	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPQ66_RS06375	COG0463	Glycosyl transferase, family 2
HPQ66_RS06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPQ66_RS06390	COG0477	Major facilitator Superfamily
HPQ66_RS06395	COG2362	D-Aminopeptidase
HPQ66_RS06400	COG0601	transmembrane transport
HPQ66_RS06405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPQ66_RS06410	COG0444	Belongs to the ABC transporter superfamily
HPQ66_RS06415	COG4166	transmembrane transport
HPQ66_RS06420	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPQ66_RS06425	COG4948	Mandelate Racemase Muconate Lactonizing
HPQ66_RS06430	COG0791	NLP P60 protein
HPQ66_RS06435	COG4608	Belongs to the ABC transporter superfamily
HPQ66_RS06440	COG2706	6-phosphogluconolactonase activity
HPQ66_RS06445	COG1834	amidinotransferase
HPQ66_RS06450	COG1607	acyl-coa hydrolase
HPQ66_RS06455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPQ66_RS06460	COG2076	Multidrug Resistance protein
HPQ66_RS06465	COG2076	Multidrug Resistance protein
HPQ66_RS06470	COG0788	formyltetrahydrofolate deformylase activity
HPQ66_RS06475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPQ66_RS06485	COG1764	response to oxidative stress
HPQ66_RS06490	COG1846	Transcriptional regulator
HPQ66_RS06495	COG1764	response to oxidative stress
HPQ66_RS06510	COG0457	Tetratricopeptide repeat
HPQ66_RS06510	COG0463	Glycosyl transferase, family 2
HPQ66_RS06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPQ66_RS06535	COG1404	Belongs to the peptidase S8 family
HPQ66_RS06540	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS06545	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPQ66_RS06550	COG1122	ATPase activity
HPQ66_RS06555	COG4721	ABC-type cobalt transport system, permease component
HPQ66_RS06560	COG1388	LysM domain
HPQ66_RS06560	COG3858	chitin binding
HPQ66_RS06570	COG2239	Acts as a magnesium transporter
HPQ66_RS06575	COG0789	Transcriptional regulator
HPQ66_RS06590	COG1846	Transcriptional regulator
HPQ66_RS06595	COG0726	polysaccharide deacetylase
HPQ66_RS06600	COG3285	dna ligase
HPQ66_RS06600	COG1793	dna ligase
HPQ66_RS06605	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HPQ66_RS06610	COG0586	Pfam SNARE associated Golgi protein
HPQ66_RS06615	COG0861	Integral membrane protein TerC family
HPQ66_RS06620	COG1191	sigma factor activity
HPQ66_RS06645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPQ66_RS06650	COG2323	membrane
HPQ66_RS06660	COG3594	Acyltransferase
HPQ66_RS06665	COG5002	protein histidine kinase activity
HPQ66_RS06670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPQ66_RS06685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPQ66_RS06690	COG0436	Aminotransferase
HPQ66_RS06720	COG3852	Histidine kinase
HPQ66_RS06725	COG1846	Transcriptional regulator
HPQ66_RS06730	COG1360	Flagellar Motor Protein
HPQ66_RS06735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPQ66_RS06740	COG0542	response to heat
HPQ66_RS06745	COG3949	Membrane
HPQ66_RS06760	COG0720	synthase
HPQ66_RS06765	COG0602	queuosine metabolic process
HPQ66_RS06790	COG4873	Protein conserved in bacteria
HPQ66_RS06800	COG3773	Cell wall hydrolase
HPQ66_RS06805	COG2244	polysaccharide biosynthetic process
HPQ66_RS06810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS06815	COG2217	Heavy metal translocating P-type atpase
HPQ66_RS06820	COG0006	proline dipeptidase activity
HPQ66_RS06825	COG1609	Transcriptional regulator
HPQ66_RS06830	COG3711	transcriptional antiterminator
HPQ66_RS06835	COG2190	(PTS) system
HPQ66_RS06835	COG1263	PTS System
HPQ66_RS06835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS06840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS06845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPQ66_RS06855	COG1533	DNA photolyase activity
HPQ66_RS06860	COG0840	transmembrane signaling receptor activity
HPQ66_RS06865	COG2084	Dehydrogenase
HPQ66_RS06870	COG2340	Cysteine-rich secretory protein family
HPQ66_RS06875	COG0768	penicillin binding
HPQ66_RS06885	COG0436	Aminotransferase
HPQ66_RS06895	COG0784	Response regulator, receiver
HPQ66_RS06895	COG0835	chemotaxis
HPQ66_RS06905	COG2814	Major facilitator Superfamily
HPQ66_RS06910	COG1376	ErfK ybiS ycfS ynhG family protein
HPQ66_RS06915	COG1408	metallophosphoesterase
HPQ66_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS06930	COG2200	EAL domain
HPQ66_RS06935	COG4703	Protein of unknown function (DUF1797)
HPQ66_RS06940	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HPQ66_RS06950	COG0517	IMP dehydrogenase activity
HPQ66_RS06955	COG0583	DNA-binding transcription factor activity
HPQ66_RS06960	COG0716	FMN binding
HPQ66_RS06970	COG0716	FMN binding
HPQ66_RS06990	COG0668	transmembrane transport
HPQ66_RS06995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS07015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPQ66_RS07020	COG0303	'Molybdopterin
HPQ66_RS07025	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPQ66_RS07030	COG0314	molybdopterin synthase activity
HPQ66_RS07035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPQ66_RS07045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPQ66_RS07050	COG1136	(ABC) transporter
HPQ66_RS07055	COG0577	efflux transmembrane transporter activity
HPQ66_RS07060	COG1349	DNA-binding transcription factor activity
HPQ66_RS07065	COG1105	Belongs to the carbohydrate kinase PfkB family
HPQ66_RS07070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPQ66_RS07070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS07070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPQ66_RS07075	COG0681	Belongs to the peptidase S26 family
HPQ66_RS07085	COG0488	(ABC) transporter
HPQ66_RS07090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPQ66_RS07095	COG2309	aminopeptidase activity
HPQ66_RS07105	COG1077	Cell shape determining protein MreB Mrl
HPQ66_RS07110	COG2002	toxin-antitoxin pair type II binding
HPQ66_RS07115	COG3852	Histidine kinase
HPQ66_RS07120	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HPQ66_RS07120	COG2105	PFAM AIG2 family protein
HPQ66_RS07125	COG0569	domain protein
HPQ66_RS07135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPQ66_RS07145	COG0561	phosphatase activity
HPQ66_RS07150	COG0242	peptide deformylase activity
HPQ66_RS07160	COG0497	DNA recombination
HPQ66_RS07170	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS07170	COG3321	synthase
HPQ66_RS07170	COG4221	oxidoreductase activity
HPQ66_RS07170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS07175	COG4221	oxidoreductase activity
HPQ66_RS07175	COG0300	oxidoreductase activity
HPQ66_RS07175	COG3321	synthase
HPQ66_RS07175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS07180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS07180	COG4221	oxidoreductase activity
HPQ66_RS07180	COG3321	synthase
HPQ66_RS07185	COG0300	oxidoreductase activity
HPQ66_RS07185	COG3321	synthase
HPQ66_RS07185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS07185	COG4221	oxidoreductase activity
HPQ66_RS07190	COG4221	oxidoreductase activity
HPQ66_RS07190	COG3321	synthase
HPQ66_RS07190	COG0300	oxidoreductase activity
HPQ66_RS07190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS07195	COG4221	oxidoreductase activity
HPQ66_RS07195	COG3321	synthase
HPQ66_RS07195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS07195	COG0300	oxidoreductase activity
HPQ66_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS07200	COG3321	synthase
HPQ66_RS07200	COG4221	oxidoreductase activity
HPQ66_RS07200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS07205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPQ66_RS07210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPQ66_RS07215	COG0022	dehydrogenase e1 component
HPQ66_RS07220	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPQ66_RS07225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPQ66_RS07230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS07245	COG1982	Orn Lys Arg decarboxylase major
HPQ66_RS07265	COG0483	inositol monophosphate 1-phosphatase activity
HPQ66_RS07275	COG3227	Zinc metalloprotease (Elastase)
HPQ66_RS07280	COG1595	DNA-templated transcription, initiation
HPQ66_RS07310	COG4896	Protein conserved in bacteria
HPQ66_RS07320	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPQ66_RS07325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPQ66_RS07330	COG2066	Belongs to the glutaminase family
HPQ66_RS07340	COG0772	Belongs to the SEDS family
HPQ66_RS07345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HPQ66_RS07360	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPQ66_RS07360	COG2010	Cytochrome c
HPQ66_RS07365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPQ66_RS07370	COG1845	cytochrome c oxidase, subunit III
HPQ66_RS07375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPQ66_RS07380	COG3336	cytochrome c oxidase
HPQ66_RS07390	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPQ66_RS07395	COG2340	Cysteine-rich secretory protein family
HPQ66_RS07410	COG3679	Belongs to the UPF0342 family
HPQ66_RS07425	COG0742	ribosomal rna small subunit methyltransferase
HPQ66_RS07435	COG3314	Sporulation integral membrane protein YlbJ
HPQ66_RS07440	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPQ66_RS07445	COG3480	Lon protease (S16) C-terminal proteolytic domain
HPQ66_RS07455	COG1399	metal-binding, possibly nucleic acid-binding protein
HPQ66_RS07475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPQ66_RS07495	COG4839	cell division protein FtsL
HPQ66_RS07505	COG0768	penicillin binding
HPQ66_RS07525	COG0772	Belongs to the SEDS family
HPQ66_RS07540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPQ66_RS07545	COG0849	cell division
HPQ66_RS07550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPQ66_RS07555	COG1404	Belongs to the peptidase S8 family
HPQ66_RS07555	COG4412	M6 family metalloprotease domain protein
HPQ66_RS07565	COG1191	sigma factor activity
HPQ66_RS07570	COG1191	sigma factor activity
HPQ66_RS07575	COG1119	ATPase activity
HPQ66_RS07580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPQ66_RS07585	COG1873	PFAM PRC-barrel domain
HPQ66_RS07595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPQ66_RS07605	COG0762	integral membrane protein
HPQ66_RS07610	COG2302	S4 RNA-binding domain
HPQ66_RS07615	COG3599	regulation of cell shape
HPQ66_RS07620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPQ66_RS07625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPQ66_RS07635	COG0564	pseudouridine synthase activity
HPQ66_RS07645	COG2233	PERMEase
HPQ66_RS07655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPQ66_RS07660	COG0505	Belongs to the CarA family
HPQ66_RS07665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPQ66_RS07680	COG0284	orotidine-5'-phosphate decarboxylase activity
HPQ66_RS07685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPQ66_RS07695	COG0306	phosphate transporter
HPQ66_RS07710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPQ66_RS07715	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HPQ66_RS07720	COG1648	precorrin-2 dehydrogenase activity
HPQ66_RS07730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPQ66_RS07735	COG1561	YicC-like family, N-terminal region
HPQ66_RS07745	COG0194	GDP metabolic process
HPQ66_RS07755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPQ66_RS07760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPQ66_RS07765	COG0242	peptide deformylase activity
HPQ66_RS07775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPQ66_RS07775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPQ66_RS07785	COG0631	protein serine/threonine phosphatase activity
HPQ66_RS07790	COG2815	serine threonine protein kinase
HPQ66_RS07790	COG0515	serine threonine protein kinase
HPQ66_RS07800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPQ66_RS07805	COG1564	THIamine pyrophosphokinase
HPQ66_RS07820	COG1302	Protein conserved in bacteria
HPQ66_RS07825	COG1461	Dihydroxyacetone kinase
HPQ66_RS07830	COG1760	l-serine dehydratase
HPQ66_RS07835	COG1760	l-serine dehydratase
HPQ66_RS07840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPQ66_RS07855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPQ66_RS07860	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS07875	COG1196	nuclear chromosome segregation
HPQ66_RS07880	COG0552	protein localization to endoplasmic reticulum
HPQ66_RS07895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPQ66_RS07905	COG1837	Belongs to the UPF0109 family
HPQ66_RS07930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPQ66_RS07945	COG2257	FlhB HrpN YscU SpaS Family
HPQ66_RS07955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPQ66_RS07960	COG0758	DNA mediated transformation
HPQ66_RS07965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPQ66_RS07975	COG4974	Belongs to the 'phage' integrase family
HPQ66_RS07995	COG1815	bacterial-type flagellum-dependent cell motility
HPQ66_RS08000	COG1558	bacterial-type flagellum-dependent cell motility
HPQ66_RS08005	COG1677	Flagellar hook-basal body complex protein FliE
HPQ66_RS08010	COG1766	The M ring may be actively involved in energy transduction
HPQ66_RS08015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPQ66_RS08020	COG1317	bacterial-type flagellum organization
HPQ66_RS08025	COG1157	protein secretion by the type III secretion system
HPQ66_RS08030	COG2882	bacterial-type flagellum organization
HPQ66_RS08035	COG3334	PFAM MgtE intracellular
HPQ66_RS08040	COG3144	bacterial-type flagellum assembly
HPQ66_RS08045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPQ66_RS08050	COG4786	Flagellar basal body rod
HPQ66_RS08055	COG1582	Flagellar protein (FlbD)
HPQ66_RS08060	COG1580	Controls the rotational direction of flagella during chemotaxis
HPQ66_RS08065	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPQ66_RS08070	COG1776	CheC inhibitor of MCP methylation
HPQ66_RS08070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPQ66_RS08075	COG2201	protein-glutamate methylesterase activity
HPQ66_RS08080	COG3190	flagellar
HPQ66_RS08085	COG1338	Plays a role in the flagellum-specific transport system
HPQ66_RS08090	COG1987	bacterial-type flagellum assembly
HPQ66_RS08095	COG1684	flagellar biosynthetic protein fliR
HPQ66_RS08100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPQ66_RS08105	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPQ66_RS08110	COG1419	protein localization to endoplasmic reticulum
HPQ66_RS08115	COG0455	bacterial-type flagellum organization
HPQ66_RS08120	COG2201	protein-glutamate methylesterase activity
HPQ66_RS08125	COG2198	Histidine kinase
HPQ66_RS08125	COG0643	Histidine kinase
HPQ66_RS08130	COG0835	chemotaxis
HPQ66_RS08135	COG1776	CheC inhibitor of MCP methylation
HPQ66_RS08145	COG1191	sigma factor activity
HPQ66_RS08175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPQ66_RS08180	COG4589	Belongs to the CDS family
HPQ66_RS08190	COG0750	zinc metalloprotease
HPQ66_RS08200	COG2176	DNA-directed DNA polymerase activity
HPQ66_RS08210	COG0195	Participates in both transcription termination and antitermination
HPQ66_RS08215	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HPQ66_RS08220	COG1358	cellular component organization or biogenesis
HPQ66_RS08230	COG1550	Protein conserved in bacteria
HPQ66_RS08245	COG0196	riboflavin kinase activity
HPQ66_RS08260	COG0726	polysaccharide deacetylase
HPQ66_RS08265	COG0612	Peptidase, M16
HPQ66_RS08270	COG1873	PFAM PRC-barrel domain
HPQ66_RS08275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPQ66_RS08280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPQ66_RS08285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPQ66_RS08290	COG0527	aspartate kinase activity
HPQ66_RS08300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPQ66_RS08305	COG0740	serine-type endopeptidase activity
HPQ66_RS08315	COG4980	gas vesicle protein
HPQ66_RS08315	COG1674	ftsk spoiiie
HPQ66_RS08320	COG2188	Transcriptional regulator
HPQ66_RS08325	COG2814	Major facilitator Superfamily
HPQ66_RS08330	COG1846	Transcriptional regulator
HPQ66_RS08335	COG2409	Drug exporters of the RND superfamily
HPQ66_RS08335	COG1033	growth of symbiont in host cell
HPQ66_RS08340	COG0612	Peptidase, M16
HPQ66_RS08345	COG0612	Peptidase, M16
HPQ66_RS08350	COG0300	oxidoreductase activity
HPQ66_RS08365	COG1426	Protein conserved in bacteria
HPQ66_RS08370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPQ66_RS08385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPQ66_RS08395	COG1692	metallophosphoesterase
HPQ66_RS08400	COG2359	stage V sporulation protein S
HPQ66_RS08420	COG4550	Control of competence regulator ComK, YlbF/YmcA
HPQ66_RS08490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS08495	COG3425	synthase
HPQ66_RS08500	COG1024	Enoyl-CoA hydratase
HPQ66_RS08505	COG1024	Enoyl-CoA hydratase
HPQ66_RS08510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS08510	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS08510	COG0300	oxidoreductase activity
HPQ66_RS08510	COG3321	synthase
HPQ66_RS08510	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS08515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS08515	COG0300	oxidoreductase activity
HPQ66_RS08515	COG3321	synthase
HPQ66_RS08515	COG4221	oxidoreductase activity
HPQ66_RS08520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS08520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS08520	COG3321	synthase
HPQ66_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS08520	COG3321	synthase
HPQ66_RS08520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS08520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS08520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS08520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS08525	COG3321	synthase
HPQ66_RS08525	COG4221	oxidoreductase activity
HPQ66_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS08525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS08530	COG3321	synthase
HPQ66_RS08530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPQ66_RS08530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS08530	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HPQ66_RS08535	COG2124	cytochrome p450
HPQ66_RS08540	COG3209	COG3209 Rhs family protein
HPQ66_RS08545	COG3619	membrane
HPQ66_RS08555	COG1404	Belongs to the peptidase S8 family
HPQ66_RS08565	COG4195	phage-related replication protein
HPQ66_RS08570	COG1764	response to oxidative stress
HPQ66_RS08580	COG2076	Multidrug Resistance protein
HPQ66_RS08620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPQ66_RS08625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPQ66_RS08630	COG4112	unkown
HPQ66_RS08635	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS08640	COG0464	growth
HPQ66_RS08645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPQ66_RS08650	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPQ66_RS08655	COG0789	Transcriptional regulator
HPQ66_RS08660	COG0174	glutamine synthetase
HPQ66_RS08670	COG2211	Major facilitator Superfamily
HPQ66_RS08675	COG3507	Belongs to the glycosyl hydrolase 43 family
HPQ66_RS08690	COG1070	Carbohydrate kinase
HPQ66_RS08695	COG0574	Belongs to the PEP-utilizing enzyme family
HPQ66_RS08695	COG3848	Pyruvate phosphate dikinase
HPQ66_RS08710	COG1064	alcohol dehydrogenase
HPQ66_RS08730	COG0456	acetyltransferase
HPQ66_RS08750	COG3397	chitin binding
HPQ66_RS08770	COG5434	Belongs to the glycosyl hydrolase 28 family
HPQ66_RS08775	COG0756	dUTP diphosphatase activity
HPQ66_RS08780	COG4195	phage-related replication protein
HPQ66_RS08815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPQ66_RS08825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPQ66_RS08845	COG0785	Cytochrome C biogenesis protein
HPQ66_RS08850	COG2201	protein-glutamate methylesterase activity
HPQ66_RS08855	COG4846	Membrane protein involved in cytochrome C biogenesis
HPQ66_RS08865	COG0071	Belongs to the small heat shock protein (HSP20) family
HPQ66_RS08880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPQ66_RS08885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS08905	COG0824	Thioesterase
HPQ66_RS08915	COG4841	protein insertion into membrane
HPQ66_RS08925	COG1832	CoA-binding protein
HPQ66_RS08930	COG0187	DNA topoisomerase II activity
HPQ66_RS08935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPQ66_RS08945	COG1115	amino acid carrier protein
HPQ66_RS08955	COG1063	alcohol dehydrogenase
HPQ66_RS08960	COG0800	Aldolase
HPQ66_RS08965	COG1312	Catalyzes the dehydration of D-mannonate
HPQ66_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS08975	COG1609	Transcriptional regulator
HPQ66_RS08980	COG2271	Major facilitator Superfamily
HPQ66_RS09015	COG2205	protein histidine kinase activity
HPQ66_RS09020	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS09030	COG3507	Belongs to the glycosyl hydrolase 43 family
HPQ66_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS09060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPQ66_RS09065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPQ66_RS09070	COG2610	gluconate transmembrane transporter activity
HPQ66_RS09075	COG2124	cytochrome p450
HPQ66_RS09095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPQ66_RS09105	COG2246	polysaccharide biosynthetic process
HPQ66_RS09110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPQ66_RS09115	COG0586	Pfam SNARE associated Golgi protein
HPQ66_RS09120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPQ66_RS09125	COG1024	Enoyl-CoA hydratase
HPQ66_RS09130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPQ66_RS09135	COG0511	ligase activity, forming carbon-carbon bonds
HPQ66_RS09140	COG0439	Biotin carboxylase
HPQ66_RS09145	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS09150	COG1960	acyl-CoA dehydrogenase activity
HPQ66_RS09155	COG1649	PFAM Uncharacterised BCR, COG1649
HPQ66_RS09165	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HPQ66_RS09165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS09170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS09175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS09185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS09190	COG2027	D-alanyl-D-alanine carboxypeptidase
HPQ66_RS09195	COG2017	converts alpha-aldose to the beta-anomer
HPQ66_RS09200	COG0534	Mate efflux family protein
HPQ66_RS09215	COG0582	viral genome integration into host DNA
HPQ66_RS09220	COG0166	Belongs to the GPI family
HPQ66_RS09225	COG0405	Gamma-glutamyltransferase
HPQ66_RS09230	COG2814	Major facilitator Superfamily
HPQ66_RS09235	COG0640	Transcriptional regulator
HPQ66_RS09250	COG0604	alcohol dehydrogenase
HPQ66_RS09260	COG0493	'glutamate synthase
HPQ66_RS09265	COG0067	glutamate synthase
HPQ66_RS09265	COG0070	glutamate synthase
HPQ66_RS09265	COG0069	glutamate synthase activity
HPQ66_RS09270	COG0583	DNA-binding transcription factor activity
HPQ66_RS09275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPQ66_RS09290	COG0300	oxidoreductase activity
HPQ66_RS09295	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HPQ66_RS09305	COG2814	Major facilitator Superfamily
HPQ66_RS09310	COG1070	Carbohydrate kinase
HPQ66_RS09315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPQ66_RS09320	COG0243	molybdopterin cofactor binding
HPQ66_RS09340	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS09345	COG1733	regulation of RNA biosynthetic process
HPQ66_RS09350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPQ66_RS09355	COG2207	Transcriptional regulator
HPQ66_RS09355	COG0662	Cupin 2, conserved barrel domain protein
HPQ66_RS09360	COG1309	transcriptional regulator
HPQ66_RS09365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS09375	COG0640	Transcriptional regulator
HPQ66_RS09380	COG0741	lytic transglycosylase activity
HPQ66_RS09385	COG2322	membrane
HPQ66_RS09400	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPQ66_RS09410	COG3584	3D domain protein
HPQ66_RS09410	COG1388	LysM domain
HPQ66_RS09415	COG0514	ATP-dependent DNA helicase (RecQ)
HPQ66_RS09425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HPQ66_RS09430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPQ66_RS09445	COG0071	Belongs to the small heat shock protein (HSP20) family
HPQ66_RS09475	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS09480	COG1657	PFAM Prenyltransferase squalene oxidase
HPQ66_RS09485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPQ66_RS09490	COG0733	neurotransmitter:sodium symporter activity
HPQ66_RS09495	COG0385	Bile acid
HPQ66_RS09500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS09505	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPQ66_RS09515	COG4548	von Willebrand factor, type A
HPQ66_RS09520	COG0714	Associated with various cellular activities
HPQ66_RS09525	COG2032	superoxide dismutase activity
HPQ66_RS09530	COG0791	NLP P60 protein
HPQ66_RS09530	COG1388	LysM domain
HPQ66_RS09535	COG1819	glycosyl
HPQ66_RS09540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPQ66_RS09545	COG0534	Mate efflux family protein
HPQ66_RS09550	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS09555	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPQ66_RS09560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPQ66_RS09570	COG2962	Rard protein
HPQ66_RS09585	COG1942	4-Oxalocrotonate Tautomerase
HPQ66_RS09595	COG1733	regulation of RNA biosynthetic process
HPQ66_RS09600	COG0778	Nitroreductase
HPQ66_RS09605	COG0400	carboxylic ester hydrolase activity
HPQ66_RS09610	COG0346	lactoylglutathione lyase activity
HPQ66_RS09620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPQ66_RS09630	COG2723	6-phospho-beta-galactosidase activity
HPQ66_RS09635	COG2188	Transcriptional regulator
HPQ66_RS09640	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS09640	COG0793	Belongs to the peptidase S41A family
HPQ66_RS09645	COG2226	methyltransferase
HPQ66_RS09655	COG1876	peptidase activity
HPQ66_RS09675	COG0671	phosphoesterase, PA-phosphatase related
HPQ66_RS09710	COG1509	lysine 2,3-aminomutase activity
HPQ66_RS09715	COG0456	acetyltransferase
HPQ66_RS09720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPQ66_RS09725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPQ66_RS09730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPQ66_RS09735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPQ66_RS09750	COG0456	acetyltransferase
HPQ66_RS09755	COG0463	Glycosyl transferase, family 2
HPQ66_RS09770	COG4641	Protein conserved in bacteria
HPQ66_RS09780	COG1086	Polysaccharide biosynthesis protein
HPQ66_RS09805	COG1388	LysM domain
HPQ66_RS09820	COG3391	amine dehydrogenase activity
HPQ66_RS09835	COG5444	nuclease activity
HPQ66_RS09840	COG4282	regulation of fungal-type cell wall biogenesis
HPQ66_RS09850	COG1525	nuclease
HPQ66_RS09865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPQ66_RS09885	COG1846	Transcriptional regulator
HPQ66_RS09890	COG4698	Protein conserved in bacteria
HPQ66_RS09895	COG2755	lipolytic protein G-D-S-L family
HPQ66_RS09900	COG1999	signal sequence binding
HPQ66_RS09910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPQ66_RS09915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPQ66_RS09920	COG1272	protein, Hemolysin III
HPQ66_RS09925	COG0204	Acyl-transferase
HPQ66_RS09930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPQ66_RS09945	COG2521	methyltransferase
HPQ66_RS09945	COG2136	Putative SAM-dependent methyltransferase
HPQ66_RS09960	COG1413	lyase activity
HPQ66_RS09965	COG1418	mRNA catabolic process
HPQ66_RS09970	COG0386	Belongs to the glutathione peroxidase family
HPQ66_RS09980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPQ66_RS09990	COG1278	Cold shock
HPQ66_RS10010	COG0328	RNA-DNA hybrid ribonuclease activity
HPQ66_RS10015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPQ66_RS10020	COG0328	RNA-DNA hybrid ribonuclease activity
HPQ66_RS10030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPQ66_RS10045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPQ66_RS10055	COG1755	Isoprenylcysteine carboxyl methyltransferase
HPQ66_RS10060	COG3424	synthase
HPQ66_RS10085	COG1335	isochorismatase
HPQ66_RS10095	COG2233	PERMEase
HPQ66_RS10105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HPQ66_RS10110	COG1199	ATP-dependent helicase activity
HPQ66_RS10130	COG0116	Belongs to the methyltransferase superfamily
HPQ66_RS10160	COG3359	exonuclease
HPQ66_RS10165	COG1111	helicase
HPQ66_RS10165	COG1205	dead DEAH box helicase
HPQ66_RS10170	COG2190	(PTS) system
HPQ66_RS10175	COG0071	Belongs to the small heat shock protein (HSP20) family
HPQ66_RS10215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPQ66_RS10215	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPQ66_RS10225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPQ66_RS10230	COG3935	DnaD domain protein
HPQ66_RS10240	COG0436	Aminotransferase
HPQ66_RS10245	COG5353	protein conserved in bacteria
HPQ66_RS10255	COG1199	ATP-dependent helicase activity
HPQ66_RS10255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPQ66_RS10285	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS10290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPQ66_RS10305	COG1694	Mazg nucleotide pyrophosphohydrolase
HPQ66_RS10310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS10315	COG2140	Oxalate decarboxylase
HPQ66_RS10325	COG4347	Protein of unknown function (DUF1405)
HPQ66_RS10330	COG2010	Cytochrome c
HPQ66_RS10330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPQ66_RS10335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPQ66_RS10340	COG0723	plastoquinol--plastocyanin reductase activity
HPQ66_RS10355	COG0457	Tetratricopeptide repeat
HPQ66_RS10365	COG0287	Prephenate dehydrogenase
HPQ66_RS10400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPQ66_RS10405	COG4401	Chorismate mutase type I
HPQ66_RS10420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPQ66_RS10425	COG0105	UTP biosynthetic process
HPQ66_RS10430	COG0142	geranyltranstransferase activity
HPQ66_RS10440	COG0142	geranyltranstransferase activity
HPQ66_RS10455	COG0776	regulation of translation
HPQ66_RS10460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPQ66_RS10500	COG0539	negative regulation of cytoplasmic translation
HPQ66_RS10515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HPQ66_RS10520	COG2959	enzyme of heme biosynthesis
HPQ66_RS10525	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS10525	COG3773	Cell wall hydrolase
HPQ66_RS10530	COG2339	peptidase activity
HPQ66_RS10535	COG0492	ferredoxin-NADP+ reductase activity
HPQ66_RS10540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPQ66_RS10545	COG4862	establishment of competence for transformation
HPQ66_RS10550	COG1408	metallophosphoesterase
HPQ66_RS10560	COG1388	LysM domain
HPQ66_RS10565	COG1266	CAAX protease self-immunity
HPQ66_RS10570	COG0514	ATP-dependent DNA helicase (RecQ)
HPQ66_RS10575	COG4955	Helix-turn-helix domain
HPQ66_RS10580	COG1141	Ferredoxin
HPQ66_RS10585	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HPQ66_RS10590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPQ66_RS10600	COG1595	DNA-templated transcription, initiation
HPQ66_RS10605	COG5002	protein histidine kinase activity
HPQ66_RS10610	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS10615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPQ66_RS10620	COG1333	cytochrome c biogenesis protein
HPQ66_RS10625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS10630	COG1187	pseudouridine synthase activity
HPQ66_RS10635	COG0700	Nucleoside recognition
HPQ66_RS10640	COG2715	membrane protein required for spore maturation
HPQ66_RS10645	COG1686	Belongs to the peptidase S11 family
HPQ66_RS10670	COG1547	Domain of unknown function (DUF309)
HPQ66_RS10675	COG0456	acetyltransferase
HPQ66_RS10690	COG0307	riboflavin synthase, alpha
HPQ66_RS10695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPQ66_RS10695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPQ66_RS10705	COG0681	Belongs to the peptidase S26 family
HPQ66_RS10715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPQ66_RS10720	COG4086	secreted protein
HPQ66_RS10725	COG0019	diaminopimelate decarboxylase activity
HPQ66_RS10730	COG0697	spore germination
HPQ66_RS10745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPQ66_RS10765	COG1191	sigma factor activity
HPQ66_RS10775	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS10780	COG1686	Belongs to the peptidase S11 family
HPQ66_RS10785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPQ66_RS10790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPQ66_RS10795	COG4974	Belongs to the 'phage' integrase family
HPQ66_RS10805	COG0735	belongs to the Fur family
HPQ66_RS10810	COG1300	Membrane
HPQ66_RS10825	COG0281	malic enzyme
HPQ66_RS10830	COG1757	Na H antiporter
HPQ66_RS10835	COG1027	Aspartate ammonia-lyase
HPQ66_RS10840	COG0252	asparaginase activity
HPQ66_RS10845	COG1396	sequence-specific DNA binding
HPQ66_RS10850	COG1379	DNA repair
HPQ66_RS10855	COG0494	nUDIX hydrolase
HPQ66_RS10865	COG0667	Aldo Keto reductase
HPQ66_RS10875	COG1073	alpha beta
HPQ66_RS10885	COG4918	Iron-sulphur cluster biosynthesis
HPQ66_RS10890	COG0456	acetyltransferase
HPQ66_RS10890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPQ66_RS10895	COG2329	Antibiotic biosynthesis monooxygenase
HPQ66_RS10900	COG0456	acetyltransferase
HPQ66_RS10905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPQ66_RS10920	COG0628	permease
HPQ66_RS10930	COG0346	lactoylglutathione lyase activity
HPQ66_RS10940	COG3048	D-serine ammonia-lyase activity
HPQ66_RS10945	COG0300	oxidoreductase activity
HPQ66_RS10950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS10955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPQ66_RS10960	COG1024	Enoyl-CoA hydratase
HPQ66_RS10965	COG3425	synthase
HPQ66_RS10970	COG2124	cytochrome p450
HPQ66_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS10975	COG3321	synthase
HPQ66_RS10975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS10975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS10975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS10980	COG3321	synthase
HPQ66_RS10980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS10980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS10980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS10985	COG0300	oxidoreductase activity
HPQ66_RS10985	COG3321	synthase
HPQ66_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS10985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS10985	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS10990	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS10990	COG3321	synthase
HPQ66_RS10990	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS10990	COG0300	oxidoreductase activity
HPQ66_RS10990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS10995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS10995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS10995	COG3321	synthase
HPQ66_RS10995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS11000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS11000	COG0300	oxidoreductase activity
HPQ66_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS11000	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS11000	COG3321	synthase
HPQ66_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS11005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS11005	COG3321	synthase
HPQ66_RS11005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPQ66_RS11005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS11015	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS11030	COG2070	2-Nitropropane dioxygenase
HPQ66_RS11030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPQ66_RS11035	COG0250	Participates in transcription elongation, termination and antitermination
HPQ66_RS11055	COG0596	Alpha beta hydrolase
HPQ66_RS11070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPQ66_RS11075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPQ66_RS11090	COG0706	membrane insertase activity
HPQ66_RS11095	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPQ66_RS11100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPQ66_RS11105	COG0346	lactoylglutathione lyase activity
HPQ66_RS11115	COG1376	ErfK ybiS ycfS ynhG family protein
HPQ66_RS11120	COG4129	membrane
HPQ66_RS11125	COG1126	abc transporter atp-binding protein
HPQ66_RS11130	COG0765	amino acid transport
HPQ66_RS11135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS11145	COG1597	lipid kinase activity
HPQ66_RS11150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPQ66_RS11155	COG0022	dehydrogenase e1 component
HPQ66_RS11160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPQ66_RS11165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPQ66_RS11170	COG3426	butyrate kinase activity
HPQ66_RS11175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPQ66_RS11180	COG0280	phosphate acetyltransferase
HPQ66_RS11185	COG3290	protein histidine kinase activity
HPQ66_RS11185	COG3829	transcription factor binding
HPQ66_RS11195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPQ66_RS11200	COG2079	MmgE PrpD family protein
HPQ66_RS11205	COG0372	Belongs to the citrate synthase family
HPQ66_RS11210	COG1960	acyl-CoA dehydrogenase activity
HPQ66_RS11215	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPQ66_RS11220	COG0183	Belongs to the thiolase family
HPQ66_RS11225	COG0584	glycerophosphoryl diester phosphodiesterase
HPQ66_RS11230	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS11255	COG1902	pentaerythritol trinitrate reductase activity
HPQ66_RS11270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPQ66_RS11275	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS11280	COG0750	zinc metalloprotease
HPQ66_RS11285	COG0497	DNA recombination
HPQ66_RS11295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPQ66_RS11305	COG0142	geranyltranstransferase activity
HPQ66_RS11315	COG1570	exodeoxyribonuclease VII activity
HPQ66_RS11330	COG1302	Protein conserved in bacteria
HPQ66_RS11335	COG0439	Biotin carboxylase
HPQ66_RS11340	COG0511	ligase activity, forming carbon-carbon bonds
HPQ66_RS11380	COG3854	ATPases associated with a variety of cellular activities
HPQ66_RS11395	COG0006	proline dipeptidase activity
HPQ66_RS11405	COG3872	metal-dependent enzyme
HPQ66_RS11415	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPQ66_RS11430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPQ66_RS11450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPQ66_RS11465	COG1396	sequence-specific DNA binding
HPQ66_RS11475	COG0681	Belongs to the peptidase S26 family
HPQ66_RS11500	COG4940	Competence protein ComGF
HPQ66_RS11510	COG4970	Tfp pilus assembly protein FimT
HPQ66_RS11515	COG4537	Required for transformation and DNA binding
HPQ66_RS11520	COG1459	type II secretion system
HPQ66_RS11525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPQ66_RS11530	COG0598	Magnesium transport protein CorA
HPQ66_RS11535	COG1253	flavin adenine dinucleotide binding
HPQ66_RS11540	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS11550	COG1393	Belongs to the ArsC family
HPQ66_RS11560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS11570	COG0011	TIGRFAM Protein of
HPQ66_RS11580	COG2866	Carboxypeptidase
HPQ66_RS11585	COG1940	carbohydrate kinase activity
HPQ66_RS11590	COG4483	Protein conserved in bacteria
HPQ66_RS11595	COG1757	Na H antiporter
HPQ66_RS11605	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPQ66_RS11620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPQ66_RS11625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPQ66_RS11630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPQ66_RS11635	COG0581	inorganic phosphate transmembrane transporter activity
HPQ66_RS11640	COG0573	inorganic phosphate transmembrane transporter activity
HPQ66_RS11645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPQ66_RS11655	COG0477	Major facilitator Superfamily
HPQ66_RS11660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPQ66_RS11665	COG2839	Protein conserved in bacteria
HPQ66_RS11670	COG5521	maltodextrose utilization protein MalA
HPQ66_RS11675	COG1388	LysM domain
HPQ66_RS11685	COG4709	membrane
HPQ66_RS11690	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HPQ66_RS11695	COG0735	belongs to the Fur family
HPQ66_RS11700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS11715	COG0513	Belongs to the DEAD box helicase family
HPQ66_RS11730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPQ66_RS11735	COG2384	SAM-dependent methyltransferase
HPQ66_RS11740	COG2010	Cytochrome c
HPQ66_RS11745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPQ66_RS11750	COG0358	DNA primase activity
HPQ66_RS11765	COG0517	IMP dehydrogenase activity
HPQ66_RS11770	COG0751	glycine-tRNA ligase activity
HPQ66_RS11790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPQ66_RS11795	COG0295	cytidine deaminase activity
HPQ66_RS11800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPQ66_RS11810	COG1480	7TM receptor with intracellular HD hydrolase
HPQ66_RS11815	COG1702	phosphate starvation-inducible protein PhoH
HPQ66_RS11820	COG0561	phosphatase activity
HPQ66_RS11835	COG4864	UPF0365 protein
HPQ66_RS11840	COG1030	water channel activity
HPQ66_RS11845	COG1610	YqeY-like protein
HPQ66_RS11855	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPQ66_RS11860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPQ66_RS11865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPQ66_RS11895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPQ66_RS11910	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS11925	COG1466	dna polymerase III delta subunit
HPQ66_RS11940	COG2333	competence protein COMEC
HPQ66_RS11940	COG0658	competence protein
HPQ66_RS11945	COG2131	deaminase
HPQ66_RS11950	COG1555	photosystem II stabilization
HPQ66_RS11950	COG1596	polysaccharide export
HPQ66_RS11955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPQ66_RS11960	COG2226	methyltransferase
HPQ66_RS11965	COG0799	negative regulation of ribosome biogenesis
HPQ66_RS11970	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPQ66_RS11980	COG1534	Rna-binding protein
HPQ66_RS11985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPQ66_RS11990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPQ66_RS11995	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPQ66_RS12005	COG2755	lipolytic protein G-D-S-L family
HPQ66_RS12015	COG0398	Pfam SNARE associated Golgi protein
HPQ66_RS12035	COG1794	racemase activity, acting on amino acids and derivatives
HPQ66_RS12050	COG1733	regulation of RNA biosynthetic process
HPQ66_RS12055	COG0656	L-ascorbic acid biosynthetic process
HPQ66_RS12070	COG3723	Recombinational DNA repair protein, rece pathway
HPQ66_RS12090	COG5002	protein histidine kinase activity
HPQ66_RS12090	COG0642	Histidine kinase
HPQ66_RS12095	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS12100	COG2311	Membrane
HPQ66_RS12110	COG0454	-acetyltransferase
HPQ66_RS12115	COG0563	adenylate kinase activity
HPQ66_RS12125	COG2814	Major facilitator Superfamily
HPQ66_RS12135	COG0456	acetyltransferase
HPQ66_RS12140	COG2318	DinB family
HPQ66_RS12150	COG0561	phosphatase activity
HPQ66_RS12155	COG0561	phosphatase activity
HPQ66_RS12165	COG1482	cell wall glycoprotein biosynthetic process
HPQ66_RS12170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS12170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPQ66_RS12170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPQ66_RS12175	COG3711	transcriptional antiterminator
HPQ66_RS12175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS12185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPQ66_RS12190	COG0583	DNA-binding transcription factor activity
HPQ66_RS12195	COG2814	Major facilitator Superfamily
HPQ66_RS12200	COG2124	cytochrome p450
HPQ66_RS12200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPQ66_RS12205	COG1309	transcriptional regulator
HPQ66_RS12210	COG2226	methyltransferase
HPQ66_RS12225	COG2116	formate transmembrane transporter activity
HPQ66_RS12230	COG5609	conserved protein (DUF2294)
HPQ66_RS12235	COG3383	formate dehydrogenase (NAD+) activity
HPQ66_RS12240	COG2427	Protein of unknown function (DUF1641)
HPQ66_RS12250	COG0626	cystathionine gamma-synthase activity
HPQ66_RS12255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPQ66_RS12280	COG0768	penicillin binding
HPQ66_RS12305	COG4122	O-methyltransferase activity
HPQ66_RS12310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPQ66_RS12325	COG4472	Bacterial protein of unknown function (DUF965)
HPQ66_RS12335	COG0628	permease
HPQ66_RS12340	COG1126	abc transporter atp-binding protein
HPQ66_RS12345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS12350	COG0765	amino acid transport
HPQ66_RS12355	COG0765	amino acid transport
HPQ66_RS12370	COG3881	PFAM PRC-barrel domain
HPQ66_RS12375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPQ66_RS12380	COG0457	Tetratricopeptide repeat
HPQ66_RS12390	COG1104	cysteine desulfurase activity
HPQ66_RS12395	COG1959	2 iron, 2 sulfur cluster binding
HPQ66_RS12400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPQ66_RS12405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPQ66_RS12430	COG4991	sh3 domain protein
HPQ66_RS12430	COG3103	Sh3 type 3 domain protein
HPQ66_RS12430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS12440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPQ66_RS12450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPQ66_RS12450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPQ66_RS12455	COG5416	Lipopolysaccharide assembly protein A domain
HPQ66_RS12460	COG0490	domain, Protein
HPQ66_RS12465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPQ66_RS12465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPQ66_RS12475	COG2244	polysaccharide biosynthetic process
HPQ66_RS12480	COG2323	membrane
HPQ66_RS12490	COG1862	Preprotein translocase
HPQ66_RS12530	COG1388	LysM domain
HPQ66_RS12540	COG0157	Belongs to the NadC ModD family
HPQ66_RS12545	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPQ66_RS12550	COG1104	cysteine desulfurase activity
HPQ66_RS12555	COG1827	regulation of RNA biosynthetic process
HPQ66_RS12560	COG0077	Prephenate dehydratase
HPQ66_RS12575	COG3290	protein histidine kinase activity
HPQ66_RS12580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPQ66_RS12585	COG2868	ribosomal protein
HPQ66_RS12595	COG1994	Peptidase M50
HPQ66_RS12600	COG0739	heme binding
HPQ66_RS12605	COG2894	cell division
HPQ66_RS12615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPQ66_RS12625	COG1077	Cell shape determining protein MreB Mrl
HPQ66_RS12645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPQ66_RS12650	COG0285	dihydrofolate synthase activity
HPQ66_RS12655	COG0525	valine-tRNA ligase activity
HPQ66_RS12665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPQ66_RS12670	COG1388	LysM domain
HPQ66_RS12680	COG0113	porphobilinogen synthase activity
HPQ66_RS12685	COG1587	Uroporphyrinogen-III synthase
HPQ66_RS12695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPQ66_RS12715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPQ66_RS12720	COG1067	ATP-dependent peptidase activity
HPQ66_RS12720	COG0470	DNA polymerase III
HPQ66_RS12735	COG0457	Tetratricopeptide repeat
HPQ66_RS12735	COG1477	protein flavinylation
HPQ66_RS12750	COG0473	3-isopropylmalate dehydrogenase activity
HPQ66_RS12765	COG0440	acetolactate synthase activity
HPQ66_RS12770	COG0028	Belongs to the TPP enzyme family
HPQ66_RS12795	COG0622	Phosphoesterase
HPQ66_RS12800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPQ66_RS12810	COG5401	PFAM Sporulation and spore germination
HPQ66_RS12820	COG1846	Transcriptional regulator
HPQ66_RS12825	COG2197	response regulator
HPQ66_RS12830	COG0824	Thioesterase
HPQ66_RS12835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPQ66_RS12840	COG1053	succinate dehydrogenase
HPQ66_RS12845	COG2009	succinate dehydrogenase
HPQ66_RS12850	COG1719	4-vinyl reductase, 4VR
HPQ66_RS12855	COG0527	aspartate kinase activity
HPQ66_RS12865	COG3118	belongs to the thioredoxin family
HPQ66_RS12870	COG3534	alpha-L-arabinofuranosidase
HPQ66_RS12875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPQ66_RS12880	COG2086	electron transfer activity
HPQ66_RS12885	COG1024	Enoyl-CoA hydratase
HPQ66_RS12890	COG1309	transcriptional regulator
HPQ66_RS12895	COG0318	PFAM AMP-dependent synthetase and ligase
HPQ66_RS12905	COG3766	membrane
HPQ66_RS12915	COG1796	DNA polymerase
HPQ66_RS12915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPQ66_RS12920	COG1286	toxin biosynthetic process
HPQ66_RS12935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPQ66_RS12935	COG0072	phenylalanine-tRNA ligase activity
HPQ66_RS12940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPQ66_RS12945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPQ66_RS12955	COG3835	regulator
HPQ66_RS12960	COG0277	FAD linked oxidase domain protein
HPQ66_RS12965	COG0247	lactate metabolic process
HPQ66_RS12970	COG1966	Carbon starvation protein
HPQ66_RS12975	COG3534	alpha-L-arabinofuranosidase
HPQ66_RS12980	COG0395	ABC-type sugar transport system, permease component
HPQ66_RS12985	COG1175	transmembrane transport
HPQ66_RS12990	COG1653	transport
HPQ66_RS13000	COG0647	UMP catabolic process
HPQ66_RS13005	COG0235	Class ii aldolase
HPQ66_RS13010	COG1069	ribulokinase activity
HPQ66_RS13015	COG2160	L-arabinose isomerase activity
HPQ66_RS13020	COG3507	Belongs to the glycosyl hydrolase 43 family
HPQ66_RS13025	COG1363	Peptidase, m42
HPQ66_RS13035	COG3326	Membrane
HPQ66_RS13040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPQ66_RS13050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPQ66_RS13055	COG1346	cytolysis
HPQ66_RS13060	COG1380	Effector of murein hydrolase LrgA
HPQ66_RS13065	COG3279	Response regulator of the LytR AlgR family
HPQ66_RS13070	COG3275	phosphorelay sensor kinase activity
HPQ66_RS13075	COG1011	Hydrolase
HPQ66_RS13090	COG0398	Pfam SNARE associated Golgi protein
HPQ66_RS13095	COG1484	DNA-dependent DNA replication
HPQ66_RS13100	COG3611	Membrane attachment protein
HPQ66_RS13115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPQ66_RS13120	COG1733	regulation of RNA biosynthetic process
HPQ66_RS13125	COG2814	Major facilitator Superfamily
HPQ66_RS13130	COG0656	L-ascorbic acid biosynthetic process
HPQ66_RS13135	COG0237	dephospho-CoA kinase activity
HPQ66_RS13140	COG1971	Probably functions as a manganese efflux pump
HPQ66_RS13145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPQ66_RS13150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPQ66_RS13150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPQ66_RS13155	COG5002	protein histidine kinase activity
HPQ66_RS13160	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS13170	COG0538	isocitrate dehydrogenase activity
HPQ66_RS13175	COG0372	Belongs to the citrate synthase family
HPQ66_RS13195	COG0628	permease
HPQ66_RS13200	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPQ66_RS13205	COG0469	pyruvate kinase activity
HPQ66_RS13225	COG0281	malic enzyme
HPQ66_RS13230	COG0587	DNA-directed DNA polymerase activity
HPQ66_RS13250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPQ66_RS13260	COG4109	DRTGG domain
HPQ66_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS13285	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPQ66_RS13295	COG0827	DNA restriction-modification system
HPQ66_RS13300	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPQ66_RS13305	COG3874	Sporulation protein YtfJ
HPQ66_RS13315	COG1714	RDD family
HPQ66_RS13320	COG0616	signal peptide processing
HPQ66_RS13325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPQ66_RS13330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPQ66_RS13335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPQ66_RS13350	COG1104	cysteine desulfurase activity
HPQ66_RS13355	COG1114	Component of the transport system for branched-chain amino acids
HPQ66_RS13365	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HPQ66_RS13370	COG1309	transcriptional regulator
HPQ66_RS13375	COG1956	GAF domain-containing protein
HPQ66_RS13380	COG2199	diguanylate cyclase activity
HPQ66_RS13380	COG2203	Gaf domain
HPQ66_RS13390	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS13400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPQ66_RS13400	COG1017	nitric oxide dioxygenase activity
HPQ66_RS13410	COG0693	protein deglycase activity
HPQ66_RS13430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HPQ66_RS13435	COG1378	Sugar-specific transcriptional regulator TrmB
HPQ66_RS13455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPQ66_RS13460	COG0454	-acetyltransferase
HPQ66_RS13465	COG0517	IMP dehydrogenase activity
HPQ66_RS13470	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPQ66_RS13475	COG1360	Flagellar Motor Protein
HPQ66_RS13480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPQ66_RS13485	COG1609	Transcriptional regulator
HPQ66_RS13490	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPQ66_RS13490	COG1605	Chorismate mutase
HPQ66_RS13495	COG3118	belongs to the thioredoxin family
HPQ66_RS13500	COG4980	gas vesicle protein
HPQ66_RS13505	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HPQ66_RS13515	COG1674	ftsk spoiiie
HPQ66_RS13520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPQ66_RS13530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS13540	COG1363	Peptidase, m42
HPQ66_RS13545	COG5584	Small secreted protein
HPQ66_RS13550	COG0281	malic enzyme
HPQ66_RS13555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPQ66_RS13570	COG0510	thiamine kinase activity
HPQ66_RS13575	COG1597	lipid kinase activity
HPQ66_RS13585	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPQ66_RS13590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPQ66_RS13595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPQ66_RS13600	COG2252	PERMEase
HPQ66_RS13605	COG4473	ABC transporter
HPQ66_RS13610	COG1131	(ABC) transporter
HPQ66_RS13615	COG1349	DNA-binding transcription factor activity
HPQ66_RS13620	COG1187	pseudouridine synthase activity
HPQ66_RS13625	COG2244	polysaccharide biosynthetic process
HPQ66_RS13630	COG2081	HI0933 family
HPQ66_RS13635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPQ66_RS13645	COG1609	Transcriptional regulator
HPQ66_RS13650	COG1653	transport
HPQ66_RS13655	COG1175	transmembrane transport
HPQ66_RS13660	COG0395	ABC-type sugar transport system, permease component
HPQ66_RS13665	COG1486	melibiose metabolic process
HPQ66_RS13675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPQ66_RS13690	COG1366	Belongs to the anti-sigma-factor antagonist family
HPQ66_RS13690	COG2202	Pas domain
HPQ66_RS13695	COG2814	Major facilitator Superfamily
HPQ66_RS13700	COG5522	Integral membrane protein (intg_mem_TP0381)
HPQ66_RS13705	COG0577	efflux transmembrane transporter activity
HPQ66_RS13710	COG1136	(ABC) transporter
HPQ66_RS13715	COG2205	protein histidine kinase activity
HPQ66_RS13720	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS13725	COG0577	efflux transmembrane transporter activity
HPQ66_RS13730	COG1136	(ABC) transporter
HPQ66_RS13750	COG1131	(ABC) transporter
HPQ66_RS13755	COG1725	Transcriptional regulator
HPQ66_RS13765	COG1242	4 iron, 4 sulfur cluster binding
HPQ66_RS13770	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HPQ66_RS13785	COG2267	carboxylic ester hydrolase activity
HPQ66_RS13790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPQ66_RS13795	COG1113	amino acid transport
HPQ66_RS13800	COG0367	asparagine synthase
HPQ66_RS13820	COG1506	peptidase
HPQ66_RS13825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPQ66_RS13830	COG1116	anion transmembrane transporter activity
HPQ66_RS13835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPQ66_RS13840	COG0494	nUDIX hydrolase
HPQ66_RS13845	COG4824	toxin secretion phage lysis holin
HPQ66_RS13850	COG0783	Belongs to the Dps family
HPQ66_RS13875	COG0288	reversible hydration of carbon dioxide
HPQ66_RS13885	COG1271	oxidase subunit
HPQ66_RS13890	COG1294	oxidase, subunit
HPQ66_RS13900	COG4948	Mandelate Racemase Muconate Lactonizing
HPQ66_RS13910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPQ66_RS13915	COG0596	Alpha beta hydrolase
HPQ66_RS13925	COG1169	isochorismate synthase
HPQ66_RS13930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPQ66_RS13935	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HPQ66_RS14060	COG3859	Proton-coupled thiamine transporter YuaJ
HPQ66_RS14065	COG2268	Band 7 protein
HPQ66_RS14070	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPQ66_RS14075	COG2318	DinB family
HPQ66_RS14085	COG1454	alcohol dehydrogenase
HPQ66_RS14090	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS14095	COG1510	regulation of RNA biosynthetic process
HPQ66_RS14105	COG0569	domain protein
HPQ66_RS14110	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPQ66_RS14115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPQ66_RS14115	COG1017	nitric oxide dioxygenase activity
HPQ66_RS14130	COG0457	Tetratricopeptide repeat
HPQ66_RS14150	COG0628	permease
HPQ66_RS14155	COG0673	inositol 2-dehydrogenase activity
HPQ66_RS14160	COG0693	protein deglycase activity
HPQ66_RS14165	COG0840	transmembrane signaling receptor activity
HPQ66_RS14170	COG0840	transmembrane signaling receptor activity
HPQ66_RS14175	COG0840	transmembrane signaling receptor activity
HPQ66_RS14180	COG0840	transmembrane signaling receptor activity
HPQ66_RS14195	COG2070	2-Nitropropane dioxygenase
HPQ66_RS14200	COG0432	Pfam Uncharacterised protein family UPF0047
HPQ66_RS14205	COG0366	Alpha amylase catalytic
HPQ66_RS14210	COG1253	flavin adenine dinucleotide binding
HPQ66_RS14215	COG2738	Putative neutral zinc metallopeptidase
HPQ66_RS14230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPQ66_RS14255	COG1335	isochorismatase
HPQ66_RS14260	COG1979	alcohol dehydrogenase
HPQ66_RS14265	COG1979	alcohol dehydrogenase
HPQ66_RS14270	COG2155	Conserved Protein
HPQ66_RS14275	COG1098	S1 RNA binding domain
HPQ66_RS14280	COG0436	Aminotransferase
HPQ66_RS14285	COG1522	sequence-specific DNA binding
HPQ66_RS14290	COG2267	carboxylic ester hydrolase activity
HPQ66_RS14300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPQ66_RS14305	COG2205	protein histidine kinase activity
HPQ66_RS14315	COG5018	Exonuclease
HPQ66_RS14320	COG2814	Major facilitator Superfamily
HPQ66_RS14325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPQ66_RS14330	COG3011	Protein conserved in bacteria
HPQ66_RS14340	COG3290	protein histidine kinase activity
HPQ66_RS14345	COG4565	transcriptional regulatory protein
HPQ66_RS14375	COG2111	Na H antiporter
HPQ66_RS14375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPQ66_RS14380	COG2111	Na H antiporter
HPQ66_RS14385	COG1006	Multisubunit Na H antiporter MnhC subunit
HPQ66_RS14390	COG0651	ATP synthesis coupled electron transport
HPQ66_RS14395	COG1863	multisubunit Na H antiporter MnhE subunit
HPQ66_RS14400	COG2212	antiporter activity
HPQ66_RS14405	COG1320	monovalent cation:proton antiporter activity
HPQ66_RS14410	COG2050	protein possibly involved in aromatic compounds catabolism
HPQ66_RS14415	COG2197	response regulator
HPQ66_RS14420	COG4585	Histidine kinase
HPQ66_RS14430	COG0142	geranyltranstransferase activity
HPQ66_RS14445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HPQ66_RS14450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPQ66_RS14455	COG1335	isochorismatase
HPQ66_RS14460	COG5506	Protein of unknown function (DUF1694)
HPQ66_RS14475	COG0628	permease
HPQ66_RS14485	COG1418	mRNA catabolic process
HPQ66_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS14500	COG1511	domain protein
HPQ66_RS14505	COG1674	ftsk spoiiie
HPQ66_RS14505	COG0433	COG0433 Predicted ATPase
HPQ66_RS14510	COG4499	WXG100 protein secretion system (Wss), protein YukC
HPQ66_RS14515	COG5417	Belongs to the EsaB family
HPQ66_RS14520	COG4842	Belongs to the WXG100 family
HPQ66_RS14525	COG2508	Transcriptional regulator
HPQ66_RS14525	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HPQ66_RS14530	COG0686	Belongs to the AlaDH PNT family
HPQ66_RS14535	COG5634	Uncharacterized conserved protein (DUF2278)
HPQ66_RS14540	COG3251	PFAM MbtH domain protein
HPQ66_RS14545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPQ66_RS14550	COG1535	isochorismatase
HPQ66_RS14550	COG3433	isochorismatase activity
HPQ66_RS14555	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPQ66_RS14560	COG1169	isochorismate synthase
HPQ66_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS14570	COG2819	hydrolase of the alpha beta superfamily
HPQ66_RS14575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPQ66_RS14580	COG1268	BioY protein
HPQ66_RS14585	COG2056	Na+-H+ antiporter family
HPQ66_RS14595	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPQ66_RS14600	COG3584	3D domain protein
HPQ66_RS14615	COG1252	NADH dehydrogenase
HPQ66_RS14645	COG1131	(ABC) transporter
HPQ66_RS14670	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HPQ66_RS14675	COG0316	Belongs to the HesB IscA family
HPQ66_RS14685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPQ66_RS14695	COG1252	NADH dehydrogenase
HPQ66_RS14700	COG4837	Protein of unknown function (DUF1462)
HPQ66_RS14705	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPQ66_RS14710	COG0823	Involved in the tonB-independent uptake of proteins
HPQ66_RS14710	COG1506	peptidase
HPQ66_RS14710	COG4946	Tricorn protease homolog
HPQ66_RS14720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPQ66_RS14725	COG0460	homoserine dehydrogenase
HPQ66_RS14730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPQ66_RS14735	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPQ66_RS14740	COG0647	UMP catabolic process
HPQ66_RS14745	COG2445	Protein of unknown function DUF86
HPQ66_RS14750	COG4470	Protein conserved in bacteria
HPQ66_RS14760	COG0739	heme binding
HPQ66_RS14770	COG0737	Belongs to the 5'-nucleotidase family
HPQ66_RS14775	COG0730	response to heat
HPQ66_RS14780	COG1801	Protein of unknown function DUF72
HPQ66_RS14795	COG2508	Transcriptional regulator
HPQ66_RS14810	COG2814	Major facilitator Superfamily
HPQ66_RS14815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPQ66_RS14820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPQ66_RS14825	COG2356	endonuclease I
HPQ66_RS14830	COG3842	ATPase activity
HPQ66_RS14835	COG2188	Transcriptional regulator
HPQ66_RS14840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPQ66_RS14845	COG0395	ABC-type sugar transport system, permease component
HPQ66_RS14850	COG1175	transmembrane transport
HPQ66_RS14855	COG1653	transport
HPQ66_RS14860	COG2222	sugar isomerase
HPQ66_RS14865	COG0789	Transcriptional regulator
HPQ66_RS14890	COG0322	excinuclease ABC activity
HPQ66_RS14895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPQ66_RS14900	COG2226	methyltransferase
HPQ66_RS14910	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS14915	COG0719	Fe-S assembly protein
HPQ66_RS14920	COG0822	iron-sulfur transferase activity
HPQ66_RS14925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPQ66_RS14930	COG0719	Fe-S assembly protein
HPQ66_RS14935	COG0396	ATPase activity
HPQ66_RS14945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPQ66_RS14950	COG1464	Belongs to the NlpA lipoprotein family
HPQ66_RS14955	COG2011	ABC-type metal ion transport system permease component
HPQ66_RS14960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPQ66_RS14970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPQ66_RS14975	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HPQ66_RS14990	COG1393	Belongs to the ArsC family
HPQ66_RS14995	COG1960	acyl-CoA dehydrogenase activity
HPQ66_RS15000	COG0183	Belongs to the thiolase family
HPQ66_RS15005	COG1024	Enoyl-CoA hydratase
HPQ66_RS15005	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPQ66_RS15020	COG0477	Major facilitator Superfamily
HPQ66_RS15030	COG5577	PFAM Coat F domain
HPQ66_RS15035	COG1846	Transcriptional regulator
HPQ66_RS15040	COG0477	Major facilitator Superfamily
HPQ66_RS15045	COG0583	DNA-binding transcription factor activity
HPQ66_RS15065	COG1120	ATPase activity
HPQ66_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS15085	COG0783	Belongs to the Dps family
HPQ66_RS15090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPQ66_RS15095	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS15100	COG2205	protein histidine kinase activity
HPQ66_RS15100	COG2770	Histidine kinase
HPQ66_RS15110	COG1309	transcriptional regulator
HPQ66_RS15115	COG0114	fumarate hydratase activity
HPQ66_RS15125	COG0697	spore germination
HPQ66_RS15130	COG0814	amino acid
HPQ66_RS15140	COG2197	response regulator
HPQ66_RS15145	COG4585	Histidine kinase
HPQ66_RS15150	COG4758	membrane
HPQ66_RS15155	COG3595	metallopeptidase activity
HPQ66_RS15160	COG1842	Phage shock protein A
HPQ66_RS15165	COG4758	membrane
HPQ66_RS15170	COG2814	Major facilitator Superfamily
HPQ66_RS15175	COG2096	Adenosyltransferase
HPQ66_RS15180	COG1120	ATPase activity
HPQ66_RS15185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS15190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPQ66_RS15195	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS15200	COG3386	PFAM SMP-30 Gluconolaconase
HPQ66_RS15205	COG2205	protein histidine kinase activity
HPQ66_RS15210	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS15220	COG1191	sigma factor activity
HPQ66_RS15230	COG2140	Oxalate decarboxylase
HPQ66_RS15240	COG1120	ATPase activity
HPQ66_RS15245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS15250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS15255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPQ66_RS15260	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPQ66_RS15265	COG0531	amino acid
HPQ66_RS15275	COG1988	membrane-bound metal-dependent
HPQ66_RS15280	COG1368	sulfuric ester hydrolase activity
HPQ66_RS15285	COG1910	domain protein
HPQ66_RS15290	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPQ66_RS15295	COG4149	molybdate abc transporter
HPQ66_RS15300	COG2197	response regulator
HPQ66_RS15305	COG3850	Histidine kinase
HPQ66_RS15310	COG1131	(ABC) transporter
HPQ66_RS15320	COG0842	Transport permease protein
HPQ66_RS15325	COG0656	L-ascorbic acid biosynthetic process
HPQ66_RS15345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPQ66_RS15350	COG3973	AAA domain
HPQ66_RS15355	COG2860	membrane
HPQ66_RS15365	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPQ66_RS15370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPQ66_RS15375	COG2217	Heavy metal translocating P-type atpase
HPQ66_RS15380	COG2217	Heavy metal translocating P-type atpase
HPQ66_RS15385	COG2608	mercury ion transmembrane transporter activity
HPQ66_RS15390	COG1937	Protein conserved in bacteria
HPQ66_RS15395	COG0673	inositol 2-dehydrogenase activity
HPQ66_RS15405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS15410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPQ66_RS15415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS15420	COG1126	abc transporter atp-binding protein
HPQ66_RS15425	COG0765	amino acid transport
HPQ66_RS15430	COG0765	amino acid transport
HPQ66_RS15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS15440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPQ66_RS15445	COG0454	-acetyltransferase
HPQ66_RS15450	COG0583	DNA-binding transcription factor activity
HPQ66_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS15460	COG2732	(Barnase) inhibitor
HPQ66_RS15480	COG0557	exoribonuclease II activity
HPQ66_RS15485	COG1647	Serine aminopeptidase, S33
HPQ66_RS15490	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPQ66_RS15495	COG1476	TRANSCRIPTIONal
HPQ66_RS15500	COG1396	sequence-specific DNA binding
HPQ66_RS15505	COG1396	sequence-specific DNA binding
HPQ66_RS15510	COG1733	regulation of RNA biosynthetic process
HPQ66_RS15535	COG1131	(ABC) transporter
HPQ66_RS15540	COG1174	glycine betaine transport
HPQ66_RS15545	COG1732	Glycine betaine
HPQ66_RS15550	COG1174	glycine betaine transport
HPQ66_RS15555	COG0517	IMP dehydrogenase activity
HPQ66_RS15555	COG1125	glycine betaine transport
HPQ66_RS15560	COG1510	regulation of RNA biosynthetic process
HPQ66_RS15565	COG1174	glycine betaine transport
HPQ66_RS15570	COG1732	Glycine betaine
HPQ66_RS15575	COG1174	glycine betaine transport
HPQ66_RS15580	COG0517	IMP dehydrogenase activity
HPQ66_RS15580	COG1125	glycine betaine transport
HPQ66_RS15585	COG1510	regulation of RNA biosynthetic process
HPQ66_RS15590	COG2095	MarC family integral membrane protein
HPQ66_RS15595	COG3064	Membrane
HPQ66_RS15600	COG4640	response to antibiotic
HPQ66_RS15605	COG0456	acetyltransferase
HPQ66_RS15620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPQ66_RS15635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPQ66_RS15640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPQ66_RS15645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPQ66_RS15655	COG2234	aminopeptidase activity
HPQ66_RS15675	COG0126	phosphoglycerate kinase activity
HPQ66_RS15680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPQ66_RS15685	COG2390	Transcriptional regulator
HPQ66_RS15690	COG2814	Major facilitator Superfamily
HPQ66_RS15695	COG1609	Transcriptional regulator
HPQ66_RS15705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS15715	COG0583	DNA-binding transcription factor activity
HPQ66_RS15720	COG0697	spore germination
HPQ66_RS15725	COG1113	amino acid transport
HPQ66_RS15735	COG1609	Transcriptional regulator
HPQ66_RS15745	COG0561	phosphatase activity
HPQ66_RS15750	COG1737	Transcriptional regulator
HPQ66_RS15755	COG1070	Carbohydrate kinase
HPQ66_RS15780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPQ66_RS15785	COG2186	Transcriptional regulator
HPQ66_RS15790	COG1620	l-lactate permease
HPQ66_RS15795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPQ66_RS15805	COG5039	Polysaccharide pyruvyl transferase
HPQ66_RS15810	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPQ66_RS15815	COG0110	maltose O-acetyltransferase activity
HPQ66_RS15820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPQ66_RS15825	COG2244	polysaccharide biosynthetic process
HPQ66_RS15830	COG1216	Glycosyl transferase, family 2
HPQ66_RS15835	COG5039	Polysaccharide pyruvyl transferase
HPQ66_RS15840	COG1216	Glycosyl transferase, family 2
HPQ66_RS15850	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS15855	COG1215	transferase activity, transferring glycosyl groups
HPQ66_RS15860	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS15865	COG1086	Polysaccharide biosynthesis protein
HPQ66_RS15870	COG0489	protein tyrosine kinase activity
HPQ66_RS15875	COG3944	biosynthesis protein
HPQ66_RS15880	COG1396	sequence-specific DNA binding
HPQ66_RS15885	COG2272	Belongs to the type-B carboxylesterase lipase family
HPQ66_RS15895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPQ66_RS15900	COG2364	Membrane
HPQ66_RS15905	COG0456	acetyltransferase
HPQ66_RS15910	COG3479	Phenolic acid decarboxylase
HPQ66_RS15980	COG2223	nitrite transmembrane transporter activity
HPQ66_RS15985	COG1609	Transcriptional regulator
HPQ66_RS15995	COG0583	DNA-binding transcription factor activity
HPQ66_RS16000	COG2828	Protein conserved in bacteria
HPQ66_RS16005	COG0477	Major facilitator Superfamily
HPQ66_RS16005	COG2814	Major facilitator Superfamily
HPQ66_RS16010	COG1611	Belongs to the LOG family
HPQ66_RS16015	COG1694	Mazg nucleotide pyrophosphohydrolase
HPQ66_RS16020	COG0659	secondary active sulfate transmembrane transporter activity
HPQ66_RS16025	COG0288	reversible hydration of carbon dioxide
HPQ66_RS16030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPQ66_RS16035	COG4290	ribonuclease
HPQ66_RS16050	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPQ66_RS16055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS16065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPQ66_RS16075	COG1051	belongs to the nudix hydrolase family
HPQ66_RS16080	COG0492	ferredoxin-NADP+ reductase activity
HPQ66_RS16085	COG0791	NLP P60 protein
HPQ66_RS16085	COG3883	PFAM NLP P60 protein
HPQ66_RS16090	COG0457	Tetratricopeptide repeat
HPQ66_RS16095	COG5002	protein histidine kinase activity
HPQ66_RS16100	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS16110	COG1132	(ABC) transporter
HPQ66_RS16115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPQ66_RS16115	COG0140	phosphoribosyl-ATP diphosphatase activity
HPQ66_RS16140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPQ66_RS16155	COG4990	cell redox homeostasis
HPQ66_RS16160	COG0110	maltose O-acetyltransferase activity
HPQ66_RS16180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPQ66_RS16190	COG2188	Transcriptional regulator
HPQ66_RS16195	COG1309	transcriptional regulator
HPQ66_RS16200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPQ66_RS16205	COG1950	PFAM Membrane protein of
HPQ66_RS16210	COG1983	PspC domain protein
HPQ66_RS16215	COG3595	metallopeptidase activity
HPQ66_RS16230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPQ66_RS16240	COG4897	Protein conserved in bacteria
HPQ66_RS16245	COG3848	Pyruvate phosphate dikinase
HPQ66_RS16245	COG0574	Belongs to the PEP-utilizing enzyme family
HPQ66_RS16250	COG1309	transcriptional regulator
HPQ66_RS16255	COG2814	Major facilitator Superfamily
HPQ66_RS16270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPQ66_RS16280	COG3409	Peptidoglycan-binding domain 1 protein
HPQ66_RS16280	COG0793	Belongs to the peptidase S41A family
HPQ66_RS16285	COG3420	alginic acid biosynthetic process
HPQ66_RS16290	COG2177	Part of the ABC transporter FtsEX involved in
HPQ66_RS16295	COG2884	Cell division ATP-binding protein ftsE
HPQ66_RS16300	COG2010	Cytochrome c
HPQ66_RS16305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS16320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPQ66_RS16335	COG1516	flagellar protein fliS
HPQ66_RS16340	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPQ66_RS16345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPQ66_RS16365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPQ66_RS16370	COG1256	bacterial-type flagellum assembly
HPQ66_RS16370	COG4786	Flagellar basal body rod
HPQ66_RS16375	COG3418	PFAM FlgN family protein
HPQ66_RS16380	COG2747	anti-sigma28 factor FlgM
HPQ66_RS16390	COG1040	competence protein
HPQ66_RS16400	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HPQ66_RS16405	COG1307	EDD domain protein, DegV family
HPQ66_RS16410	COG2197	response regulator
HPQ66_RS16415	COG4585	Histidine kinase
HPQ66_RS16420	COG1739	Uncharacterized protein family UPF0029
HPQ66_RS16425	COG1316	TRANSCRIPTIONal
HPQ66_RS16430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPQ66_RS16435	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS16440	COG1215	transferase activity, transferring glycosyl groups
HPQ66_RS16445	COG3206	protein involved in exopolysaccharide biosynthesis
HPQ66_RS16450	COG3307	-O-antigen
HPQ66_RS16455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPQ66_RS16460	COG0297	glycogen (starch) synthase activity
HPQ66_RS16460	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS16465	COG2244	polysaccharide biosynthetic process
HPQ66_RS16475	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPQ66_RS16475	COG2247	cell wall binding repeat
HPQ66_RS16480	COG2385	sporulation resulting in formation of a cellular spore
HPQ66_RS16480	COG2247	cell wall binding repeat
HPQ66_RS16490	COG1316	TRANSCRIPTIONal
HPQ66_RS16495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPQ66_RS16500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPQ66_RS16505	COG1134	teichoic acid transport
HPQ66_RS16510	COG1682	transport, permease protein
HPQ66_RS16515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPQ66_RS16520	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS16525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPQ66_RS16530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HPQ66_RS16535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPQ66_RS16540	COG4193	domain, Protein
HPQ66_RS16545	COG1482	cell wall glycoprotein biosynthetic process
HPQ66_RS16550	COG0697	spore germination
HPQ66_RS16555	COG0814	amino acid
HPQ66_RS16565	COG1215	transferase activity, transferring glycosyl groups
HPQ66_RS16570	COG2814	Major facilitator Superfamily
HPQ66_RS16575	COG1316	TRANSCRIPTIONal
HPQ66_RS16580	COG0561	phosphatase activity
HPQ66_RS16585	COG2433	Pfam Transposase IS66
HPQ66_RS16590	COG0791	NLP P60 protein
HPQ66_RS16600	COG2843	Capsule synthesis protein
HPQ66_RS16610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPQ66_RS16615	COG0697	spore germination
HPQ66_RS16620	COG0814	amino acid
HPQ66_RS16630	COG1609	Transcriptional regulator
HPQ66_RS16635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPQ66_RS16645	COG1129	ABC transporter
HPQ66_RS16650	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPQ66_RS16655	COG1879	ABC-type sugar transport system periplasmic component
HPQ66_RS16660	COG3103	Sh3 type 3 domain protein
HPQ66_RS16665	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPQ66_RS16670	COG3527	Alpha-acetolactate decarboxylase
HPQ66_RS16675	COG0028	Belongs to the TPP enzyme family
HPQ66_RS16680	COG0583	DNA-binding transcription factor activity
HPQ66_RS16685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPQ66_RS16700	COG5337	Spore coat protein CotH
HPQ66_RS16710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPQ66_RS16720	COG0405	Gamma-glutamyltransferase
HPQ66_RS16725	COG1522	sequence-specific DNA binding
HPQ66_RS16730	COG2059	Chromate
HPQ66_RS16735	COG2059	Chromate
HPQ66_RS16745	COG0655	NAD(P)H dehydrogenase (quinone) activity
HPQ66_RS16750	COG0583	DNA-binding transcription factor activity
HPQ66_RS16770	COG5444	nuclease activity
HPQ66_RS16785	COG3878	Protein conserved in bacteria
HPQ66_RS16790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPQ66_RS16795	COG4464	protein tyrosine phosphatase activity
HPQ66_RS16800	COG0489	protein tyrosine kinase activity
HPQ66_RS16805	COG3944	biosynthesis protein
HPQ66_RS16815	COG4715	Zinc finger, swim domain protein
HPQ66_RS16820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPQ66_RS16825	COG0561	phosphatase activity
HPQ66_RS16830	COG1349	DNA-binding transcription factor activity
HPQ66_RS16835	COG0629	single-stranded DNA binding
HPQ66_RS16860	COG0457	Tetratricopeptide repeat
HPQ66_RS16865	COG4786	Flagellar basal body rod
HPQ66_RS16870	COG4786	Flagellar basal body rod
HPQ66_RS16875	COG1077	Cell shape determining protein MreB Mrl
HPQ66_RS16880	COG1609	Transcriptional regulator
HPQ66_RS16885	COG1846	Transcriptional regulator
HPQ66_RS16890	COG2814	Major facilitator Superfamily
HPQ66_RS16895	COG1953	Uracil, thiamine, allantoin
HPQ66_RS16900	COG0477	Major facilitator Superfamily
HPQ66_RS16905	COG1335	isochorismatase
HPQ66_RS16910	COG0004	ammonium transporteR
HPQ66_RS16915	COG0347	Belongs to the P(II) protein family
HPQ66_RS16920	COG0772	Belongs to the SEDS family
HPQ66_RS16925	COG0671	phosphoesterase, PA-phosphatase related
HPQ66_RS16935	COG0739	heme binding
HPQ66_RS16940	COG1247	-acetyltransferase
HPQ66_RS16955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPQ66_RS16965	COG0726	polysaccharide deacetylase
HPQ66_RS16975	COG1959	2 iron, 2 sulfur cluster binding
HPQ66_RS16990	COG0831	urea catabolic process
HPQ66_RS16995	COG3237	CsbD-like
HPQ66_RS17000	COG1994	Peptidase M50
HPQ66_RS17005	COG0457	Tetratricopeptide repeat
HPQ66_RS17015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPQ66_RS17025	COG2304	oxidoreductase activity
HPQ66_RS17030	COG2304	oxidoreductase activity
HPQ66_RS17035	COG2385	sporulation resulting in formation of a cellular spore
HPQ66_RS17040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPQ66_RS17050	COG4836	Membrane
HPQ66_RS17120	COG0698	ribose 5-phosphate isomerase
HPQ66_RS17125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPQ66_RS17135	COG0009	L-threonylcarbamoyladenylate synthase
HPQ66_RS17140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPQ66_RS17160	COG2890	protein-(glutamine-N5) methyltransferase activity
HPQ66_RS17165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPQ66_RS17170	COG0346	lactoylglutathione lyase activity
HPQ66_RS17175	COG0789	Transcriptional regulator
HPQ66_RS17180	COG0679	Auxin Efflux Carrier
HPQ66_RS17185	COG0281	malic enzyme
HPQ66_RS17200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPQ66_RS17205	COG1494	fructose-1,6-bisphosphatase
HPQ66_RS17210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPQ66_RS17220	COG0191	fructose-bisphosphate aldolase activity
HPQ66_RS17225	COG2204	response regulator
HPQ66_RS17230	COG4821	SIS domain
HPQ66_RS17245	COG2181	nitrate reductase activity
HPQ66_RS17245	COG0247	lactate metabolic process
HPQ66_RS17250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPQ66_RS17265	COG1132	(ABC) transporter
HPQ66_RS17270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPQ66_RS17280	COG2181	nitrate reductase activity
HPQ66_RS17285	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPQ66_RS17290	COG1140	nitrate reductase beta subunit
HPQ66_RS17295	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPQ66_RS17300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPQ66_RS17310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPQ66_RS17315	COG2223	nitrite transmembrane transporter activity
HPQ66_RS17325	COG4506	Protein conserved in bacteria
HPQ66_RS17335	COG3391	amine dehydrogenase activity
HPQ66_RS17340	COG3391	amine dehydrogenase activity
HPQ66_RS17345	COG0457	Tetratricopeptide repeat
HPQ66_RS17355	COG0010	Belongs to the arginase family
HPQ66_RS17360	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPQ66_RS17365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPQ66_RS17380	COG1994	Peptidase M50
HPQ66_RS17385	COG1942	4-Oxalocrotonate Tautomerase
HPQ66_RS17390	COG1846	Transcriptional regulator
HPQ66_RS17395	COG0531	amino acid
HPQ66_RS17400	COG3465	dGTPase activity
HPQ66_RS17405	COG1078	dGTPase activity
HPQ66_RS17420	COG1695	Transcriptional regulator
HPQ66_RS17430	COG1131	(ABC) transporter
HPQ66_RS17435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPQ66_RS17465	COG0583	DNA-binding transcription factor activity
HPQ66_RS17475	COG0280	phosphate acetyltransferase
HPQ66_RS17485	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS17490	COG0436	Aminotransferase
HPQ66_RS17520	COG2814	Major facilitator Superfamily
HPQ66_RS17525	COG2814	Major facilitator Superfamily
HPQ66_RS17530	COG0833	amino acid
HPQ66_RS17535	COG4187	Peptidase family M20/M25/M40
HPQ66_RS17540	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS17545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPQ66_RS17555	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HPQ66_RS17560	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPQ66_RS17565	COG1088	dTDP-glucose 4,6-dehydratase activity
HPQ66_RS17570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPQ66_RS17575	COG3980	spore coat polysaccharide biosynthesis protein
HPQ66_RS17580	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HPQ66_RS17585	COG2089	acid synthase
HPQ66_RS17590	COG0456	acetyltransferase
HPQ66_RS17595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPQ66_RS17600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HPQ66_RS17605	COG0463	Glycosyl transferase, family 2
HPQ66_RS17615	COG2363	Small membrane protein
HPQ66_RS17620	COG2233	PERMEase
HPQ66_RS17635	COG1216	Glycosyl transferase, family 2
HPQ66_RS17650	COG1695	Transcriptional regulator
HPQ66_RS17655	COG0351	phosphomethylpyrimidine kinase
HPQ66_RS17665	COG1621	beta-fructofuranosidase activity
HPQ66_RS17670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPQ66_RS17670	COG1263	PTS System
HPQ66_RS17675	COG3711	transcriptional antiterminator
HPQ66_RS17685	COG1404	Belongs to the peptidase S8 family
HPQ66_RS17690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPQ66_RS17695	COG0778	Nitroreductase
HPQ66_RS17700	COG0772	Belongs to the SEDS family
HPQ66_RS17705	COG0454	-acetyltransferase
HPQ66_RS17725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPQ66_RS17730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPQ66_RS17735	COG2261	transglycosylase associated protein
HPQ66_RS17740	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HPQ66_RS17745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HPQ66_RS17750	COG2246	polysaccharide biosynthetic process
HPQ66_RS17755	COG1309	transcriptional regulator
HPQ66_RS17775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPQ66_RS17780	COG2837	iron assimilation
HPQ66_RS17785	COG2822	iron ion transport
HPQ66_RS17800	COG0583	DNA-binding transcription factor activity
HPQ66_RS17810	COG1346	cytolysis
HPQ66_RS17815	COG4895	conserved protein (DUF2196)
HPQ66_RS17820	COG0789	Transcriptional regulator
HPQ66_RS17825	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPQ66_RS17830	COG0346	lactoylglutathione lyase activity
HPQ66_RS17835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS17840	COG1404	Belongs to the peptidase S8 family
HPQ66_RS17845	COG1442	glycosyl transferase family 8
HPQ66_RS17850	COG2357	RelA SpoT domain protein
HPQ66_RS17855	COG1575	Belongs to the MenA family. Type 1 subfamily
HPQ66_RS17870	COG1696	Membrane protein involved in D-alanine export
HPQ66_RS17880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HPQ66_RS17885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPQ66_RS17890	COG1486	melibiose metabolic process
HPQ66_RS17895	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPQ66_RS17900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS17905	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS17910	COG3711	transcriptional antiterminator
HPQ66_RS17910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPQ66_RS17920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS17925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPQ66_RS17935	COG0640	Transcriptional regulator
HPQ66_RS17940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPQ66_RS17945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS17950	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPQ66_RS17955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPQ66_RS17960	COG2723	6-phospho-beta-galactosidase activity
HPQ66_RS17965	COG1940	carbohydrate kinase activity
HPQ66_RS17970	COG1482	cell wall glycoprotein biosynthetic process
HPQ66_RS17980	COG0753	catalase activity
HPQ66_RS17985	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HPQ66_RS17990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPQ66_RS17995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPQ66_RS18000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPQ66_RS18005	COG4988	ABC transporter
HPQ66_RS18010	COG1294	oxidase, subunit
HPQ66_RS18015	COG1271	oxidase subunit
HPQ66_RS18020	COG3493	citrate carrier protein
HPQ66_RS18025	COG0726	polysaccharide deacetylase
HPQ66_RS18030	COG3842	ATPase activity
HPQ66_RS18035	COG2508	Transcriptional regulator
HPQ66_RS18040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS18050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPQ66_RS18065	COG4894	glucomannan catabolic process
HPQ66_RS18070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HPQ66_RS18075	COG0500	methyltransferase
HPQ66_RS18080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPQ66_RS18095	COG0753	catalase activity
HPQ66_RS18095	COG0693	protein deglycase activity
HPQ66_RS18100	COG2851	Citrate transporter
HPQ66_RS18105	COG2273	Hydrolase Family 16
HPQ66_RS18110	COG3711	transcriptional antiterminator
HPQ66_RS18115	COG2270	Major facilitator Superfamily
HPQ66_RS18120	COG0513	Belongs to the DEAD box helicase family
HPQ66_RS18165	COG0697	spore germination
HPQ66_RS18170	COG0589	response to stress
HPQ66_RS18180	COG0494	nUDIX hydrolase
HPQ66_RS18185	COG3507	Belongs to the glycosyl hydrolase 43 family
HPQ66_RS18210	COG0010	Belongs to the arginase family
HPQ66_RS18215	COG0833	amino acid
HPQ66_RS18220	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPQ66_RS18225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPQ66_RS18235	COG2390	Transcriptional regulator
HPQ66_RS18240	COG0561	phosphatase activity
HPQ66_RS18270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPQ66_RS18275	COG5294	Protein conserved in bacteria
HPQ66_RS18280	COG0577	efflux transmembrane transporter activity
HPQ66_RS18285	COG1136	(ABC) transporter
HPQ66_RS18290	COG2205	protein histidine kinase activity
HPQ66_RS18295	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS18300	COG2205	protein histidine kinase activity
HPQ66_RS18305	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS18330	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS18360	COG1082	Xylose isomerase domain protein TIM barrel
HPQ66_RS18370	COG2814	Major facilitator Superfamily
HPQ66_RS18400	COG1349	DNA-binding transcription factor activity
HPQ66_RS18405	COG0667	Aldo Keto reductase
HPQ66_RS18410	COG2814	Major facilitator Superfamily
HPQ66_RS18420	COG1028	Short-chain dehydrogenase reductase Sdr
HPQ66_RS18425	COG2197	response regulator
HPQ66_RS18430	COG4585	Histidine kinase
HPQ66_RS18435	COG3239	Fatty acid desaturase
HPQ66_RS18440	COG1309	transcriptional regulator
HPQ66_RS18445	COG1012	belongs to the aldehyde dehydrogenase family
HPQ66_RS18450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPQ66_RS18460	COG0640	Transcriptional regulator
HPQ66_RS18465	COG2814	Major facilitator Superfamily
HPQ66_RS18470	COG1714	RDD family
HPQ66_RS18485	COG0501	Belongs to the peptidase M48B family
HPQ66_RS18490	COG1715	Restriction endonuclease
HPQ66_RS18495	COG0450	alkyl hydroperoxide reductase
HPQ66_RS18500	COG3634	alkyl hydroperoxide reductase activity
HPQ66_RS18505	COG1113	amino acid transport
HPQ66_RS18515	COG2080	2 iron, 2 sulfur cluster binding
HPQ66_RS18530	COG2068	MobA-Related Protein
HPQ66_RS18535	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPQ66_RS18555	COG1192	Involved in chromosome partitioning
HPQ66_RS18595	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPQ66_RS18600	COG0667	Aldo Keto reductase
HPQ66_RS18605	COG0456	acetyltransferase
HPQ66_RS18610	COG0457	Tetratricopeptide repeat
HPQ66_RS18615	COG0010	Belongs to the arginase family
HPQ66_RS18620	COG0833	amino acid
HPQ66_RS18625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPQ66_RS18630	COG5658	integral membrane protein
HPQ66_RS18635	COG0640	Transcriptional regulator
HPQ66_RS18640	COG3829	transcription factor binding
HPQ66_RS18650	COG0488	(ABC) transporter
HPQ66_RS18665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPQ66_RS18675	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS18680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPQ66_RS18685	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPQ66_RS18690	COG4853	Protein conserved in bacteria
HPQ66_RS18695	COG4863	YycH protein
HPQ66_RS18700	COG5002	protein histidine kinase activity
HPQ66_RS18705	COG0745	RESPONSE REGULATOR receiver
HPQ66_RS18735	COG0346	lactoylglutathione lyase activity
HPQ66_RS18740	COG0305	Participates in initiation and elongation during chromosome replication
HPQ66_RS18755	COG3093	addiction module antidote protein HigA
HPQ66_RS18760	COG0297	glycogen (starch) synthase activity
HPQ66_RS18770	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPQ66_RS18775	COG0438	transferase activity, transferring glycosyl groups
HPQ66_RS18795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HPQ66_RS18800	COG4241	membrane
HPQ66_RS18810	COG5577	PFAM Coat F domain
HPQ66_RS18815	COG1733	regulation of RNA biosynthetic process
HPQ66_RS18825	COG0697	spore germination
HPQ66_RS18830	COG1621	beta-fructofuranosidase activity
HPQ66_RS18835	COG1621	beta-fructofuranosidase activity
HPQ66_RS18845	COG2318	DinB family
HPQ66_RS18850	COG2211	Major facilitator Superfamily
HPQ66_RS18860	COG0778	Nitroreductase
HPQ66_RS18865	COG1846	Transcriptional regulator
HPQ66_RS18870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HPQ66_RS18875	COG1846	Transcriptional regulator
HPQ66_RS18880	COG2153	protein acetylation
HPQ66_RS18885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPQ66_RS18890	COG0697	spore germination
HPQ66_RS18895	COG1078	dGTPase activity
HPQ66_RS18900	COG1846	Transcriptional regulator
HPQ66_RS18920	COG1331	Highly conserved protein containing a thioredoxin domain
HPQ66_RS18925	COG1266	CAAX protease self-immunity
HPQ66_RS18930	COG2814	Major facilitator Superfamily
HPQ66_RS18930	COG0477	Major facilitator Superfamily
HPQ66_RS18935	COG0346	lactoylglutathione lyase activity
HPQ66_RS18940	COG1609	Transcriptional regulator
HPQ66_RS18945	COG0708	Exodeoxyribonuclease III
HPQ66_RS18950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPQ66_RS18955	COG2169	Transcriptional regulator
HPQ66_RS18965	COG0629	single-stranded DNA binding
HPQ66_RS18975	COG0012	GTP binding
HPQ66_RS18980	COG0243	molybdopterin cofactor binding
HPQ66_RS18985	COG4481	Protein conserved in bacteria
HPQ66_RS18990	COG3949	Membrane
HPQ66_RS19005	COG1475	DNA binding
HPQ66_RS19010	COG1192	Involved in chromosome partitioning
HPQ66_RS19035	COG1847	R3H domain protein
HPQ66_RS19040	COG0706	membrane insertase activity